date generated: 2024-03-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
A1BG -0.2987185
A1BG-AS1 -0.4355672
A1CF -0.0075548
A2M 0.2520922
A2M-AS1 -0.8309598
A2ML1 0.0785158

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2656
num_genes_in_profile 23030
duplicated_genes_present 0
num_profile_genes_in_sets 10817
num_profile_genes_not_in_sets 12213

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2024-03-10.gmt
Gene set metrics
Gene sets metrics
num_genesets 2656
num_genesets_excluded 1026
num_genesets_included 1630

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Fatty acids 15 1.27e-06 0.722 5.10e-04
Eicosanoids 12 5.25e-05 0.674 7.04e-03
Amino Acid conjugation 9 8.38e-04 0.643 5.62e-02
Conjugation of carboxylic acids 9 8.38e-04 0.643 5.62e-02
Conjugation of salicylate with glycine 8 3.00e-03 0.606 9.74e-02
Type I hemidesmosome assembly 11 7.79e-04 -0.585 5.60e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 8 4.46e-03 0.581 1.18e-01
ChREBP activates metabolic gene expression 8 6.85e-03 -0.552 1.55e-01
Formyl peptide receptors bind formyl peptides and many other ligands 8 8.24e-03 0.539 1.67e-01
CYP2E1 reactions 11 2.20e-03 0.533 9.74e-02
EGFR interacts with phospholipase C-gamma 9 6.40e-03 -0.525 1.50e-01
Mucopolysaccharidoses 11 2.69e-03 -0.523 9.74e-02
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.71e-02 -0.521 2.90e-01
Transport of fatty acids 8 1.16e-02 -0.515 1.99e-01
Inhibition of Signaling by Overexpressed EGFR 8 1.22e-02 -0.512 2.06e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 8 1.22e-02 -0.512 2.06e-01
Conjugation of benzoate with glycine 6 3.27e-02 0.503 3.18e-01
Sulfide oxidation to sulfate 5 5.14e-02 -0.503 3.79e-01
Expression and translocation of olfactory receptors 334 1.38e-55 0.498 2.78e-52
Nef Mediated CD4 Down-regulation 9 1.10e-02 -0.490 1.95e-01
Olfactory Signaling Pathway 342 4.61e-54 0.486 4.64e-51
Reelin signalling pathway 5 6.08e-02 0.484 3.91e-01
Biosynthesis of maresin-like SPMs 6 4.23e-02 0.479 3.61e-01
Beta defensins 27 2.03e-05 0.474 4.88e-03
E2F-enabled inhibition of pre-replication complex formation 9 1.44e-02 0.471 2.22e-01
OAS antiviral response 9 1.49e-02 -0.469 2.23e-01
Defective LFNG causes SCDO3 5 7.27e-02 -0.463 4.25e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 7.32e-02 -0.463 4.25e-01
GRB7 events in ERBB2 signaling 5 7.47e-02 -0.460 4.28e-01
Regulation of CDH19 Expression and Function 7 3.52e-02 -0.460 3.27e-01
Sema4D mediated inhibition of cell attachment and migration 8 2.56e-02 -0.456 2.83e-01
NFE2L2 regulating tumorigenic genes 11 9.18e-03 -0.454 1.81e-01
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 5 7.99e-02 0.452 4.40e-01
Miscellaneous substrates 12 7.46e-03 0.446 1.65e-01
CDC6 association with the ORC:origin complex 8 2.95e-02 0.444 2.97e-01
Defensins 35 5.74e-06 0.443 1.93e-03
Uptake and function of diphtheria toxin 6 6.50e-02 -0.435 4.02e-01
Ciprofloxacin ADME 5 9.20e-02 0.435 4.63e-01
GAB1 signalosome 17 1.91e-03 -0.435 9.51e-02
Synthesis of Ketone Bodies 8 3.47e-02 -0.431 3.26e-01
Arachidonate production from DAG 5 9.50e-02 -0.431 4.69e-01
Nef Mediated CD8 Down-regulation 7 5.12e-02 -0.426 3.79e-01
Specification of the neural plate border 16 3.43e-03 0.422 1.03e-01
Antimicrobial peptides 79 9.67e-11 0.421 4.86e-08
CLEC7A/inflammasome pathway 6 7.61e-02 -0.418 4.31e-01
Activation of the phototransduction cascade 11 1.70e-02 -0.416 2.36e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 7 6.02e-02 -0.410 3.90e-01
Reversible hydration of carbon dioxide 12 1.50e-02 -0.406 2.23e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 6.86e-02 -0.398 4.08e-01
Negative feedback regulation of MAPK pathway 6 9.22e-02 -0.397 4.63e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Fatty acids 15 1.27e-06 7.22e-01 5.10e-04
Eicosanoids 12 5.25e-05 6.74e-01 7.04e-03
Amino Acid conjugation 9 8.38e-04 6.43e-01 5.62e-02
Conjugation of carboxylic acids 9 8.38e-04 6.43e-01 5.62e-02
Conjugation of salicylate with glycine 8 3.00e-03 6.06e-01 9.74e-02
Type I hemidesmosome assembly 11 7.79e-04 -5.85e-01 5.60e-02
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 8 4.46e-03 5.81e-01 1.18e-01
ChREBP activates metabolic gene expression 8 6.85e-03 -5.52e-01 1.55e-01
Formyl peptide receptors bind formyl peptides and many other ligands 8 8.24e-03 5.39e-01 1.67e-01
CYP2E1 reactions 11 2.20e-03 5.33e-01 9.74e-02
EGFR interacts with phospholipase C-gamma 9 6.40e-03 -5.25e-01 1.50e-01
Mucopolysaccharidoses 11 2.69e-03 -5.23e-01 9.74e-02
Pre-NOTCH Processing in the Endoplasmic Reticulum 6 2.71e-02 -5.21e-01 2.90e-01
Transport of fatty acids 8 1.16e-02 -5.15e-01 1.99e-01
Inhibition of Signaling by Overexpressed EGFR 8 1.22e-02 -5.12e-01 2.06e-01
Signaling by Overexpressed Wild-Type EGFR in Cancer 8 1.22e-02 -5.12e-01 2.06e-01
Conjugation of benzoate with glycine 6 3.27e-02 5.03e-01 3.18e-01
Sulfide oxidation to sulfate 5 5.14e-02 -5.03e-01 3.79e-01
Expression and translocation of olfactory receptors 334 1.38e-55 4.98e-01 2.78e-52
Nef Mediated CD4 Down-regulation 9 1.10e-02 -4.90e-01 1.95e-01
Olfactory Signaling Pathway 342 4.61e-54 4.86e-01 4.64e-51
Reelin signalling pathway 5 6.08e-02 4.84e-01 3.91e-01
Biosynthesis of maresin-like SPMs 6 4.23e-02 4.79e-01 3.61e-01
Beta defensins 27 2.03e-05 4.74e-01 4.88e-03
E2F-enabled inhibition of pre-replication complex formation 9 1.44e-02 4.71e-01 2.22e-01
OAS antiviral response 9 1.49e-02 -4.69e-01 2.23e-01
Defective LFNG causes SCDO3 5 7.27e-02 -4.63e-01 4.25e-01
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose 5 7.32e-02 -4.63e-01 4.25e-01
GRB7 events in ERBB2 signaling 5 7.47e-02 -4.60e-01 4.28e-01
Regulation of CDH19 Expression and Function 7 3.52e-02 -4.60e-01 3.27e-01
Sema4D mediated inhibition of cell attachment and migration 8 2.56e-02 -4.56e-01 2.83e-01
NFE2L2 regulating tumorigenic genes 11 9.18e-03 -4.54e-01 1.81e-01
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 5 7.99e-02 4.52e-01 4.40e-01
Miscellaneous substrates 12 7.46e-03 4.46e-01 1.65e-01
CDC6 association with the ORC:origin complex 8 2.95e-02 4.44e-01 2.97e-01
Defensins 35 5.74e-06 4.43e-01 1.93e-03
Uptake and function of diphtheria toxin 6 6.50e-02 -4.35e-01 4.02e-01
Ciprofloxacin ADME 5 9.20e-02 4.35e-01 4.63e-01
GAB1 signalosome 17 1.91e-03 -4.35e-01 9.51e-02
Synthesis of Ketone Bodies 8 3.47e-02 -4.31e-01 3.26e-01
Arachidonate production from DAG 5 9.50e-02 -4.31e-01 4.69e-01
Nef Mediated CD8 Down-regulation 7 5.12e-02 -4.26e-01 3.79e-01
Specification of the neural plate border 16 3.43e-03 4.22e-01 1.03e-01
Antimicrobial peptides 79 9.67e-11 4.21e-01 4.86e-08
CLEC7A/inflammasome pathway 6 7.61e-02 -4.18e-01 4.31e-01
Activation of the phototransduction cascade 11 1.70e-02 -4.16e-01 2.36e-01
Epithelial-Mesenchymal Transition (EMT) during gastrulation 7 6.02e-02 -4.10e-01 3.90e-01
Reversible hydration of carbon dioxide 12 1.50e-02 -4.06e-01 2.23e-01
Loss of MECP2 binding ability to the NCoR/SMRT complex 7 6.86e-02 -3.98e-01 4.08e-01
Negative feedback regulation of MAPK pathway 6 9.22e-02 -3.97e-01 4.63e-01
Estrogen-stimulated signaling through PRKCZ 6 9.41e-02 -3.95e-01 4.69e-01
RHO GTPases activate KTN1 11 2.42e-02 -3.92e-01 2.77e-01
Signaling by MST1 5 1.29e-01 -3.92e-01 5.13e-01
Activation of RAC1 downstream of NMDARs 7 7.38e-02 -3.90e-01 4.26e-01
G2 Phase 5 1.32e-01 3.89e-01 5.14e-01
Biosynthesis of maresins 8 5.73e-02 3.88e-01 3.90e-01
Release of apoptotic factors from the mitochondria 6 1.01e-01 -3.86e-01 4.79e-01
Ketone body metabolism 10 3.55e-02 -3.84e-01 3.27e-01
Prednisone ADME 10 3.63e-02 3.82e-01 3.33e-01
MECP2 regulates transcription factors 5 1.39e-01 3.82e-01 5.29e-01
Sema4D induced cell migration and growth-cone collapse 20 3.11e-03 -3.82e-01 9.91e-02
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 9 4.76e-02 3.81e-01 3.68e-01
Apoptotic cleavage of cell adhesion proteins 11 2.88e-02 -3.81e-01 2.93e-01
GRB2 events in EGFR signaling 13 1.76e-02 -3.80e-01 2.36e-01
RORA activates gene expression 18 5.23e-03 -3.80e-01 1.31e-01
MAPK1 (ERK2) activation 9 4.87e-02 -3.79e-01 3.70e-01
PP2A-mediated dephosphorylation of key metabolic factors 7 8.38e-02 -3.77e-01 4.50e-01
Regulation of CDH11 mRNA translation by microRNAs 11 3.13e-02 -3.75e-01 3.09e-01
Metal sequestration by antimicrobial proteins 6 1.12e-01 3.74e-01 4.95e-01
CD28 dependent PI3K/Akt signaling 22 2.40e-03 -3.74e-01 9.74e-02
IRAK2 mediated activation of TAK1 complex 10 4.17e-02 3.72e-01 3.61e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.62e-02 -3.71e-01 2.32e-01
APOBEC3G mediated resistance to HIV-1 infection 5 1.54e-01 3.68e-01 5.54e-01
AKT phosphorylates targets in the nucleus 10 4.62e-02 -3.64e-01 3.67e-01
Sphingolipid catabolism 12 2.95e-02 -3.63e-01 2.97e-01
Sema4D in semaphorin signaling 24 2.15e-03 -3.62e-01 9.74e-02
Chylomicron remodeling 10 4.76e-02 -3.62e-01 3.68e-01
Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5 1.64e-01 -3.59e-01 5.77e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 2.19e-02 -3.54e-01 2.66e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 24 2.71e-03 -3.54e-01 9.74e-02
Vitamin C (ascorbate) metabolism 8 8.33e-02 -3.54e-01 4.50e-01
IRF3 mediated activation of type 1 IFN 5 1.72e-01 3.53e-01 5.89e-01
Regulation of TP53 Activity through Association with Co-factors 14 2.42e-02 -3.48e-01 2.77e-01
Synthesis of PI 5 1.80e-01 -3.46e-01 5.95e-01
CDH11 homotypic and heterotypic interactions 7 1.16e-01 -3.43e-01 4.98e-01
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 8 9.37e-02 -3.42e-01 4.68e-01
NGF-independant TRKA activation 5 1.85e-01 3.42e-01 6.01e-01
Erythropoietin activates STAT5 7 1.18e-01 -3.41e-01 5.00e-01
Gamma-carboxylation of protein precursors 9 7.70e-02 -3.40e-01 4.34e-01
TNFR1-induced proapoptotic signaling 25 3.32e-03 -3.39e-01 1.01e-01
Hydrolysis of LPC 9 7.88e-02 -3.38e-01 4.38e-01
Alpha-defensins 8 9.77e-02 3.38e-01 4.75e-01
Activation of TRKA receptors 6 1.52e-01 3.38e-01 5.54e-01
Mitochondrial Uncoupling 6 1.55e-01 3.35e-01 5.54e-01
Activation of caspases through apoptosome-mediated cleavage 6 1.57e-01 3.34e-01 5.58e-01
Fructose catabolism 5 1.97e-01 -3.33e-01 6.07e-01
Serotonin receptors 12 4.71e-02 3.31e-01 3.68e-01
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 9 8.71e-02 -3.29e-01 4.51e-01
Synthesis of PG 8 1.07e-01 -3.29e-01 4.90e-01
Removal of aminoterminal propeptides from gamma-carboxylated proteins 9 8.89e-02 -3.27e-01 4.56e-01
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 10 7.31e-02 -3.27e-01 4.25e-01
Alternative complement activation 5 2.12e-01 -3.22e-01 6.18e-01
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 6.55e-02 3.21e-01 4.04e-01
Xenobiotics 24 6.76e-03 3.19e-01 1.55e-01
Regulation of TP53 Activity through Acetylation 29 2.92e-03 -3.19e-01 9.74e-02
Molybdenum cofactor biosynthesis 6 1.77e-01 3.18e-01 5.92e-01
Caspase activation via Death Receptors in the presence of ligand 16 2.76e-02 -3.18e-01 2.90e-01
LDL clearance 19 1.70e-02 -3.16e-01 2.36e-01
IL-6-type cytokine receptor ligand interactions 17 2.46e-02 -3.15e-01 2.78e-01
Formation of the ureteric bud 21 1.28e-02 3.14e-01 2.09e-01
TRIF-mediated programmed cell death 9 1.04e-01 -3.13e-01 4.85e-01
Inactivation of CDC42 and RAC1 8 1.27e-01 -3.11e-01 5.13e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 44 3.54e-04 -3.11e-01 3.39e-02
Biosynthesis of EPA-derived SPMs 6 1.88e-01 3.11e-01 6.01e-01
Glycosphingolipid transport 8 1.28e-01 -3.10e-01 5.13e-01
Regulation of IFNA/IFNB signaling 20 1.64e-02 3.10e-01 2.32e-01
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 9 1.07e-01 -3.10e-01 4.91e-01
SHC1 events in EGFR signaling 14 4.63e-02 -3.08e-01 3.67e-01
Biosynthesis of DHA-derived SPMs 17 2.85e-02 3.07e-01 2.93e-01
RUNX3 regulates WNT signaling 8 1.33e-01 -3.07e-01 5.17e-01
Formation of annular gap junctions 11 7.82e-02 -3.07e-01 4.36e-01
Regulation of localization of FOXO transcription factors 12 6.60e-02 -3.07e-01 4.04e-01
p38MAPK events 13 5.60e-02 -3.06e-01 3.90e-01
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 9 1.12e-01 3.06e-01 4.95e-01
Adenylate cyclase activating pathway 10 9.56e-02 -3.04e-01 4.70e-01
Ligand-receptor interactions 8 1.37e-01 3.04e-01 5.25e-01
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 13 5.82e-02 3.03e-01 3.90e-01
Pre-NOTCH Processing in Golgi 18 2.61e-02 -3.03e-01 2.85e-01
Displacement of DNA glycosylase by APEX1 9 1.16e-01 3.03e-01 4.98e-01
FasL/ CD95L signaling 5 2.42e-01 -3.02e-01 6.40e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 9.92e-02 -3.01e-01 4.77e-01
Regulation of commissural axon pathfinding by SLIT and ROBO 10 9.94e-02 3.01e-01 4.77e-01
NR1H2 and NR1H3-mediated signaling 54 1.37e-04 -3.00e-01 1.62e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 7.20e-02 -3.00e-01 4.25e-01
Leukotriene receptors 5 2.45e-01 -3.00e-01 6.42e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.76e-02 -2.99e-01 2.36e-01
PKA activation in glucagon signalling 17 3.29e-02 -2.99e-01 3.19e-01
Bicarbonate transporters 10 1.06e-01 -2.95e-01 4.89e-01
IRS activation 5 2.53e-01 -2.95e-01 6.48e-01
SMAC (DIABLO) binds to IAPs 7 1.78e-01 2.94e-01 5.92e-01
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 7 1.78e-01 2.94e-01 5.92e-01
SMAC, XIAP-regulated apoptotic response 7 1.78e-01 2.94e-01 5.92e-01
Repression of WNT target genes 14 5.73e-02 -2.93e-01 3.90e-01
TNFR1-mediated ceramide production 6 2.14e-01 -2.93e-01 6.18e-01
Downstream signal transduction 29 6.34e-03 -2.93e-01 1.50e-01
tRNA processing in the mitochondrion 5 2.58e-01 2.92e-01 6.51e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 12 8.11e-02 -2.91e-01 4.43e-01
Orexin and neuropeptides FF and QRFP bind to their respective receptors 8 1.55e-01 -2.90e-01 5.54e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 8.28e-02 -2.89e-01 4.50e-01
Signaling by FGFR4 in disease 11 9.69e-02 -2.89e-01 4.74e-01
Formation of the anterior neural plate 10 1.14e-01 2.88e-01 4.97e-01
Phosphate bond hydrolysis by NTPDase proteins 8 1.59e-01 -2.88e-01 5.63e-01
Pyrimidine salvage 11 9.94e-02 -2.87e-01 4.77e-01
Sensory Perception 558 3.61e-31 2.87e-01 2.42e-28
EGFR Transactivation by Gastrin 9 1.36e-01 -2.87e-01 5.25e-01
RHO GTPases activate CIT 19 3.06e-02 -2.87e-01 3.03e-01
Biosynthesis of specialized proresolving mediators (SPMs) 19 3.06e-02 2.86e-01 3.03e-01
Synthesis of wybutosine at G37 of tRNA(Phe) 6 2.24e-01 2.86e-01 6.26e-01
Defective factor VIII causes hemophilia A 7 1.94e-01 -2.84e-01 6.07e-01
Carnitine metabolism 14 6.69e-02 -2.83e-01 4.06e-01
Regulation of PTEN mRNA translation 28 9.65e-03 -2.83e-01 1.87e-01
Regulation of signaling by NODAL 9 1.43e-01 -2.82e-01 5.37e-01
Synthesis of 12-eicosatetraenoic acid derivatives 7 1.96e-01 -2.82e-01 6.07e-01
Blood group systems biosynthesis 22 2.22e-02 -2.82e-01 2.66e-01
RUNX3 regulates YAP1-mediated transcription 7 2.01e-01 -2.79e-01 6.08e-01
IkBA variant leads to EDA-ID 7 2.01e-01 -2.79e-01 6.08e-01
LTC4-CYSLTR mediated IL4 production 7 2.05e-01 -2.77e-01 6.08e-01
RHO GTPases activate PAKs 21 2.82e-02 -2.77e-01 2.93e-01
FBXW7 Mutants and NOTCH1 in Cancer 5 2.85e-01 -2.76e-01 6.76e-01
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 5 2.85e-01 -2.76e-01 6.76e-01
Glucocorticoid biosynthesis 10 1.31e-01 2.76e-01 5.13e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 39 2.91e-03 2.75e-01 9.74e-02
Synthesis, secretion, and deacylation of Ghrelin 19 4.02e-02 2.72e-01 3.55e-01
Acetylcholine inhibits contraction of outer hair cells 5 2.93e-01 -2.72e-01 6.82e-01
Regulation of TNFR1 signaling 48 1.13e-03 -2.72e-01 7.08e-02
Role of second messengers in netrin-1 signaling 10 1.37e-01 2.71e-01 5.25e-01
Lewis blood group biosynthesis 18 4.62e-02 -2.71e-01 3.67e-01
Smooth Muscle Contraction 42 2.55e-03 -2.69e-01 9.74e-02
Organic anion transport 5 3.00e-01 -2.68e-01 6.86e-01
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 8 1.90e-01 -2.68e-01 6.05e-01
Signaling by KIT in disease 20 3.84e-02 -2.67e-01 3.43e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 3.84e-02 -2.67e-01 3.43e-01
Glycerophospholipid catabolism 7 2.21e-01 -2.67e-01 6.26e-01
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 5 3.01e-01 -2.67e-01 6.87e-01
Plasma lipoprotein assembly 19 4.47e-02 -2.66e-01 3.67e-01
Polo-like kinase mediated events 16 6.57e-02 2.66e-01 4.04e-01
Gap junction degradation 12 1.12e-01 -2.65e-01 4.95e-01
FLT3 signaling by CBL mutants 7 2.26e-01 2.64e-01 6.26e-01
Translesion synthesis by POLK 17 5.99e-02 2.64e-01 3.90e-01
XBP1(S) activates chaperone genes 44 2.57e-03 -2.63e-01 9.74e-02
GP1b-IX-V activation signalling 12 1.15e-01 -2.63e-01 4.98e-01
HDL assembly 8 1.99e-01 -2.62e-01 6.07e-01
Evasion by RSV of host interferon responses 29 1.47e-02 2.62e-01 2.23e-01
SOS-mediated signalling 7 2.32e-01 -2.61e-01 6.31e-01
Cytochrome P450 - arranged by substrate type 65 2.82e-04 2.60e-01 2.88e-02
PECAM1 interactions 12 1.19e-01 -2.60e-01 5.00e-01
LDL remodeling 6 2.70e-01 2.60e-01 6.68e-01
Platelet sensitization by LDL 17 6.41e-02 -2.59e-01 3.99e-01
Cytosolic iron-sulfur cluster assembly 13 1.07e-01 -2.58e-01 4.89e-01
Tyrosine catabolism 5 3.17e-01 -2.58e-01 7.03e-01
Coenzyme A biosynthesis 7 2.37e-01 -2.58e-01 6.36e-01
Interleukin-21 signaling 10 1.58e-01 -2.58e-01 5.61e-01
RHOV GTPase cycle 37 6.71e-03 -2.57e-01 1.55e-01
ERBB2 Activates PTK6 Signaling 13 1.09e-01 -2.57e-01 4.92e-01
Regulation of NFE2L2 gene expression 8 2.10e-01 -2.56e-01 6.15e-01
Paracetamol ADME 27 2.16e-02 -2.55e-01 2.66e-01
VEGFR2 mediated vascular permeability 27 2.17e-02 -2.55e-01 2.66e-01
Degradation of cysteine and homocysteine 14 9.87e-02 -2.55e-01 4.77e-01
Sensing of DNA Double Strand Breaks 6 2.80e-01 2.55e-01 6.74e-01
Fructose metabolism 7 2.45e-01 -2.54e-01 6.42e-01
Diseases associated with visual transduction 12 1.30e-01 -2.52e-01 5.13e-01
Diseases of the neuronal system 12 1.30e-01 -2.52e-01 5.13e-01
Retinoid cycle disease events 12 1.30e-01 -2.52e-01 5.13e-01
DEx/H-box helicases activate type I IFN and inflammatory cytokines production 7 2.50e-01 -2.51e-01 6.47e-01
Pyroptosis 27 2.43e-02 -2.50e-01 2.77e-01
Aryl hydrocarbon receptor signalling 7 2.54e-01 -2.49e-01 6.48e-01
Translesion synthesis by POLI 17 7.62e-02 2.48e-01 4.31e-01
Translesion synthesis by REV1 16 8.54e-02 2.48e-01 4.50e-01
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 5 3.37e-01 -2.48e-01 7.12e-01
Retrograde neurotrophin signalling 14 1.09e-01 -2.48e-01 4.92e-01
Noncanonical activation of NOTCH3 8 2.25e-01 -2.48e-01 6.26e-01
Interleukin-23 signaling 9 1.99e-01 -2.47e-01 6.07e-01
Interleukin-9 signaling 8 2.28e-01 -2.46e-01 6.26e-01
NGF-stimulated transcription 39 7.93e-03 2.46e-01 1.67e-01
Sodium/Calcium exchangers 11 1.59e-01 2.45e-01 5.63e-01
Notch-HLH transcription pathway 28 2.54e-02 -2.44e-01 2.83e-01
IRE1alpha activates chaperones 46 4.28e-03 -2.43e-01 1.15e-01
Diseases of Mismatch Repair (MMR) 5 3.48e-01 2.42e-01 7.17e-01
SUMOylation of DNA methylation proteins 16 9.36e-02 -2.42e-01 4.68e-01
NTRK2 activates RAC1 5 3.49e-01 2.42e-01 7.17e-01
Binding of TCF/LEF:CTNNB1 to target gene promoters 8 2.37e-01 -2.42e-01 6.36e-01
Tight junction interactions 29 2.46e-02 -2.41e-01 2.78e-01
HS-GAG degradation 24 4.14e-02 -2.41e-01 3.60e-01
Regulation of RUNX1 Expression and Activity 26 3.38e-02 -2.40e-01 3.22e-01
APC truncation mutants have impaired AXIN binding 14 1.21e-01 -2.39e-01 5.00e-01
AXIN missense mutants destabilize the destruction complex 14 1.21e-01 -2.39e-01 5.00e-01
Signaling by AMER1 mutants 14 1.21e-01 -2.39e-01 5.00e-01
Signaling by APC mutants 14 1.21e-01 -2.39e-01 5.00e-01
Signaling by AXIN mutants 14 1.21e-01 -2.39e-01 5.00e-01
Truncations of AMER1 destabilize the destruction complex 14 1.21e-01 -2.39e-01 5.00e-01
tRNA modification in the mitochondrion 9 2.15e-01 2.39e-01 6.18e-01
Highly calcium permeable nicotinic acetylcholine receptors 9 2.15e-01 2.39e-01 6.18e-01
Regulated proteolysis of p75NTR 11 1.70e-01 -2.39e-01 5.87e-01
Cell-extracellular matrix interactions 18 7.99e-02 -2.38e-01 4.40e-01
NFE2L2 regulating MDR associated enzymes 8 2.45e-01 -2.37e-01 6.42e-01
Activation of C3 and C5 7 2.78e-01 -2.37e-01 6.74e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.49e-02 2.37e-01 3.67e-01
WNT mediated activation of DVL 8 2.47e-01 -2.36e-01 6.44e-01
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 11 1.75e-01 2.36e-01 5.92e-01
Activation of PUMA and translocation to mitochondria 9 2.20e-01 -2.36e-01 6.26e-01
NrCAM interactions 7 2.80e-01 -2.36e-01 6.74e-01
Amine ligand-binding receptors 42 8.18e-03 2.36e-01 1.67e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 1.27e-01 -2.35e-01 5.13e-01
RAF activation 33 1.96e-02 -2.35e-01 2.51e-01
Sensory perception of salty taste 6 3.20e-01 -2.34e-01 7.06e-01
Activation of Ca-permeable Kainate Receptor 10 2.03e-01 2.32e-01 6.08e-01
Ionotropic activity of kainate receptors 10 2.03e-01 2.32e-01 6.08e-01
HDL clearance 5 3.68e-01 -2.32e-01 7.39e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 52 3.79e-03 2.32e-01 1.07e-01
p53-Independent DNA Damage Response 52 3.79e-03 2.32e-01 1.07e-01
p53-Independent G1/S DNA damage checkpoint 52 3.79e-03 2.32e-01 1.07e-01
Interleukin-20 family signaling 26 4.06e-02 -2.32e-01 3.56e-01
TYSND1 cleaves peroxisomal proteins 7 2.88e-01 -2.32e-01 6.78e-01
Glycosphingolipid biosynthesis 19 8.09e-02 -2.31e-01 4.43e-01
Interleukin-6 family signaling 24 5.02e-02 -2.31e-01 3.77e-01
Glutathione synthesis and recycling 12 1.67e-01 -2.30e-01 5.81e-01
Ca2+ activated K+ channels 9 2.32e-01 -2.30e-01 6.31e-01
Syndecan interactions 27 3.90e-02 -2.29e-01 3.47e-01
Respiratory syncytial virus (RSV) attachment and entry 23 5.70e-02 -2.29e-01 3.90e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 1.27e-01 -2.27e-01 5.13e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 1.27e-01 -2.27e-01 5.13e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 1.27e-01 -2.27e-01 5.13e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 1.27e-01 -2.27e-01 5.13e-01
Signaling by CTNNB1 phospho-site mutants 15 1.27e-01 -2.27e-01 5.13e-01
Signaling by GSK3beta mutants 15 1.27e-01 -2.27e-01 5.13e-01
CD28 co-stimulation 33 2.38e-02 -2.27e-01 2.77e-01
FCGR activation 12 1.75e-01 2.26e-01 5.92e-01
SUMOylation of immune response proteins 12 1.76e-01 -2.26e-01 5.92e-01
Interleukin-1 processing 9 2.41e-01 -2.25e-01 6.40e-01
Prolonged ERK activation events 14 1.44e-01 -2.25e-01 5.42e-01
Common Pathway of Fibrin Clot Formation 22 6.75e-02 -2.25e-01 4.07e-01
Frs2-mediated activation 12 1.77e-01 -2.25e-01 5.92e-01
The fatty acid cycling model 5 3.85e-01 2.24e-01 7.51e-01
The proton buffering model 5 3.85e-01 2.24e-01 7.51e-01
Folding of actin by CCT/TriC 10 2.20e-01 2.24e-01 6.26e-01
RUNX1 regulates transcription of genes involved in BCR signaling 6 3.42e-01 2.24e-01 7.12e-01
Acyl chain remodelling of PC 27 4.43e-02 -2.24e-01 3.67e-01
Regulation of Expression and Function of Type II Classical Cadherins 33 2.63e-02 -2.23e-01 2.85e-01
Regulation of Homotypic Cell-Cell Adhesion 33 2.63e-02 -2.23e-01 2.85e-01
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 7 3.09e-01 -2.22e-01 6.97e-01
Signaling by EGFR 53 5.15e-03 -2.22e-01 1.31e-01
Biosynthesis of E-series 18(S)-resolvins 5 3.91e-01 2.21e-01 7.54e-01
Impaired BRCA2 binding to PALB2 24 6.05e-02 2.21e-01 3.90e-01
Tandem pore domain potassium channels 12 1.86e-01 2.20e-01 6.01e-01
Defective HLCS causes multiple carboxylase deficiency 7 3.13e-01 -2.20e-01 7.02e-01
IFNG signaling activates MAPKs 8 2.82e-01 -2.20e-01 6.76e-01
Phase 1 - inactivation of fast Na+ channels 7 3.15e-01 2.20e-01 7.03e-01
Maturation of protein 3a 9683673 9 2.54e-01 -2.19e-01 6.48e-01
Maturation of protein 3a 9694719 9 2.54e-01 -2.19e-01 6.48e-01
Defective F9 activation 6 3.54e-01 2.19e-01 7.19e-01
TLR3-mediated TICAM1-dependent programmed cell death 6 3.54e-01 -2.19e-01 7.19e-01
Pregnenolone biosynthesis 12 1.92e-01 -2.17e-01 6.07e-01
Regulation of gene expression in early pancreatic precursor cells 8 2.87e-01 2.17e-01 6.77e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 1.93e-01 -2.17e-01 6.07e-01
CTLA4 inhibitory signaling 21 8.52e-02 -2.17e-01 4.50e-01
Regulation of CDH11 Expression and Function 30 4.01e-02 -2.17e-01 3.55e-01
FGFR3b ligand binding and activation 7 3.22e-01 -2.16e-01 7.06e-01
CASP8 activity is inhibited 11 2.15e-01 -2.16e-01 6.18e-01
Dimerization of procaspase-8 11 2.15e-01 -2.16e-01 6.18e-01
Regulation by c-FLIP 11 2.15e-01 -2.16e-01 6.18e-01
Hh mutants are degraded by ERAD 56 5.22e-03 2.16e-01 1.31e-01
Histidine catabolism 8 2.92e-01 -2.15e-01 6.82e-01
HDL remodeling 10 2.39e-01 -2.15e-01 6.39e-01
Chylomicron assembly 10 2.39e-01 -2.15e-01 6.39e-01
CD163 mediating an anti-inflammatory response 9 2.65e-01 -2.14e-01 6.62e-01
TNF signaling 57 5.20e-03 -2.14e-01 1.31e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 1.83e-01 -2.13e-01 5.97e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 128 3.04e-05 2.13e-01 5.09e-03
Prolactin receptor signaling 15 1.53e-01 -2.13e-01 5.54e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 76 1.34e-03 2.13e-01 7.68e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 14 1.68e-01 2.13e-01 5.84e-01
SUMO is conjugated to E1 (UBA2:SAE1) 5 4.10e-01 2.13e-01 7.67e-01
Chylomicron clearance 5 4.10e-01 -2.13e-01 7.67e-01
PI3K events in ERBB2 signaling 16 1.41e-01 -2.12e-01 5.35e-01
Vitamins 6 3.68e-01 2.12e-01 7.39e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 77 1.31e-03 2.12e-01 7.68e-02
NOTCH4 Intracellular Domain Regulates Transcription 20 1.01e-01 -2.12e-01 4.79e-01
Defective CFTR causes cystic fibrosis 61 4.27e-03 2.12e-01 1.15e-01
Plasma lipoprotein clearance 37 2.62e-02 -2.11e-01 2.85e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 6.85e-02 2.10e-01 4.08e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 6.85e-02 2.10e-01 4.08e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 6.85e-02 2.10e-01 4.08e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 6.85e-02 2.10e-01 4.08e-01
Beta-oxidation of very long chain fatty acids 11 2.28e-01 -2.10e-01 6.26e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 5.48e-02 -2.10e-01 3.87e-01
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 7 3.38e-01 -2.09e-01 7.12e-01
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant 7 3.38e-01 -2.09e-01 7.12e-01
Sodium-coupled phosphate cotransporters 5 4.18e-01 -2.09e-01 7.69e-01
Defective C1GALT1C1 causes TNPS 19 1.15e-01 2.09e-01 4.98e-01
APC/C:Cdc20 mediated degradation of Securin 68 2.89e-03 2.09e-01 9.74e-02
rRNA modification in the mitochondrion 6 3.77e-01 -2.08e-01 7.47e-01
RHOU GTPase cycle 40 2.27e-02 -2.08e-01 2.68e-01
RUNX1 regulates transcription of genes involved in WNT signaling 6 3.77e-01 2.08e-01 7.47e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 21 9.87e-02 2.08e-01 4.77e-01
Establishment of Sister Chromatid Cohesion 11 2.32e-01 2.08e-01 6.31e-01
Formation of lateral plate mesoderm 5 4.21e-01 2.08e-01 7.69e-01
Nuclear events stimulated by ALK signaling in cancer 35 3.34e-02 -2.08e-01 3.22e-01
CREB phosphorylation 7 3.41e-01 2.08e-01 7.12e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 55 7.79e-03 2.07e-01 1.67e-01
DNA methylation 28 5.77e-02 -2.07e-01 3.90e-01
G2/M DNA replication checkpoint 5 4.22e-01 2.07e-01 7.69e-01
Interleukin-36 pathway 7 3.43e-01 2.07e-01 7.12e-01
Ubiquitin-dependent degradation of Cyclin D 52 1.00e-02 2.06e-01 1.92e-01
Acyl chain remodelling of PE 29 5.44e-02 -2.06e-01 3.87e-01
Activated NTRK2 signals through RAS 9 2.85e-01 2.06e-01 6.76e-01
Disorders of Developmental Biology 13 1.99e-01 -2.06e-01 6.07e-01
Disorders of Nervous System Development 13 1.99e-01 -2.06e-01 6.07e-01
Loss of function of MECP2 in Rett syndrome 13 1.99e-01 -2.06e-01 6.07e-01
Pervasive developmental disorders 13 1.99e-01 -2.06e-01 6.07e-01
Activation of BAD and translocation to mitochondria 15 1.68e-01 -2.06e-01 5.84e-01
Loss of Function of SMAD2/3 in Cancer 7 3.46e-01 2.06e-01 7.16e-01
CDK-mediated phosphorylation and removal of Cdc6 73 2.43e-03 2.05e-01 9.74e-02
Activation of gene expression by SREBF (SREBP) 42 2.15e-02 -2.05e-01 2.66e-01
Orc1 removal from chromatin 71 2.83e-03 2.05e-01 9.74e-02
CHL1 interactions 9 2.89e-01 2.04e-01 6.79e-01
Stabilization of p53 56 8.32e-03 2.04e-01 1.67e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 50 1.27e-02 2.04e-01 2.09e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 7.82e-02 -2.03e-01 4.36e-01
Signaling by NTRK3 (TRKC) 17 1.47e-01 -2.03e-01 5.46e-01
Pre-NOTCH Expression and Processing 84 1.32e-03 -2.03e-01 7.68e-02
Zinc efflux and compartmentalization by the SLC30 family 5 4.33e-01 2.02e-01 7.77e-01
Disinhibition of SNARE formation 5 4.35e-01 2.02e-01 7.77e-01
Semaphorin interactions 64 5.28e-03 -2.02e-01 1.31e-01
Vif-mediated degradation of APOBEC3G 54 1.04e-02 2.02e-01 1.93e-01
Thrombin signalling through proteinase activated receptors (PARs) 32 4.84e-02 -2.02e-01 3.69e-01
Signal attenuation 10 2.71e-01 -2.01e-01 6.68e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 73 2.96e-03 2.01e-01 9.74e-02
Autodegradation of the E3 ubiquitin ligase COP1 51 1.31e-02 2.01e-01 2.10e-01
Synthesis of 5-eicosatetraenoic acids 9 2.97e-01 2.01e-01 6.84e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 74 2.86e-03 2.00e-01 9.74e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 1.95e-01 -2.00e-01 6.07e-01
Defective EXT2 causes exostoses 2 14 1.95e-01 -2.00e-01 6.07e-01
Other semaphorin interactions 19 1.31e-01 -2.00e-01 5.13e-01
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 9 3.00e-01 -2.00e-01 6.86e-01
Hh mutants abrogate ligand secretion 59 8.07e-03 1.99e-01 1.67e-01
Intrinsic Pathway for Apoptosis 54 1.13e-02 -1.99e-01 1.97e-01
Lysine catabolism 12 2.32e-01 1.99e-01 6.31e-01
Adenylate cyclase inhibitory pathway 14 1.98e-01 -1.99e-01 6.07e-01
Activation of the pre-replicative complex 33 4.85e-02 1.98e-01 3.69e-01
Eicosanoid ligand-binding receptors 15 1.84e-01 -1.98e-01 5.98e-01
TNFR1-induced NF-kappa-B signaling pathway 33 4.89e-02 -1.98e-01 3.70e-01
Metabolism of ingested SeMet, Sec, MeSec into H2Se 8 3.35e-01 -1.97e-01 7.12e-01
Cell junction organization 117 2.36e-04 -1.97e-01 2.63e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 21 1.20e-01 1.96e-01 5.00e-01
Defective RIPK1-mediated regulated necrosis 7 3.70e-01 -1.96e-01 7.40e-01
PKA activation 18 1.51e-01 -1.96e-01 5.54e-01
Regulation of Apoptosis 53 1.39e-02 1.95e-01 2.18e-01
TBC/RABGAPs 44 2.51e-02 -1.95e-01 2.82e-01
Diseases of carbohydrate metabolism 33 5.27e-02 -1.95e-01 3.83e-01
Translesion Synthesis by POLH 18 1.52e-01 1.95e-01 5.54e-01
Phosphorylation of Emi1 6 4.09e-01 1.95e-01 7.67e-01
MAPK3 (ERK1) activation 10 2.87e-01 -1.95e-01 6.77e-01
Terminal pathway of complement 8 3.41e-01 1.94e-01 7.12e-01
APC-Cdc20 mediated degradation of Nek2A 26 8.65e-02 1.94e-01 4.51e-01
Estrogen biosynthesis 6 4.12e-01 -1.94e-01 7.67e-01
MET activates PTPN11 5 4.54e-01 1.93e-01 7.88e-01
G1/S DNA Damage Checkpoints 67 6.27e-03 1.93e-01 1.50e-01
Choline catabolism 6 4.13e-01 -1.93e-01 7.67e-01
Asymmetric localization of PCP proteins 64 7.60e-03 1.93e-01 1.66e-01
Post-transcriptional silencing by small RNAs 7 3.77e-01 -1.93e-01 7.47e-01
Netrin mediated repulsion signals 8 3.45e-01 1.93e-01 7.15e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 74 4.18e-03 1.93e-01 1.15e-01
Degradation of AXIN 55 1.35e-02 1.93e-01 2.14e-01
NOTCH3 Intracellular Domain Regulates Transcription 25 9.57e-02 -1.93e-01 4.70e-01
SUMO is proteolytically processed 6 4.15e-01 1.92e-01 7.67e-01
Integrin signaling 27 8.40e-02 -1.92e-01 4.50e-01
Striated Muscle Contraction 36 4.61e-02 -1.92e-01 3.67e-01
SCF(Skp2)-mediated degradation of p27/p21 60 1.02e-02 1.92e-01 1.93e-01
Switching of origins to a post-replicative state 92 1.53e-03 1.91e-01 8.01e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 2.33e-01 -1.91e-01 6.31e-01
RHO GTPases Activate Rhotekin and Rhophilins 9 3.21e-01 -1.91e-01 7.06e-01
Activation of ATR in response to replication stress 37 4.47e-02 1.91e-01 3.67e-01
SMAD2/3 Phosphorylation Motif Mutants in Cancer 6 4.19e-01 1.91e-01 7.69e-01
TGFBR1 KD Mutants in Cancer 6 4.19e-01 1.91e-01 7.69e-01
TRAF6 mediated IRF7 activation 24 1.06e-01 1.90e-01 4.89e-01
Signaling by TGF-beta Receptor Complex in Cancer 8 3.51e-01 1.90e-01 7.17e-01
STAT5 Activation 7 3.83e-01 -1.90e-01 7.51e-01
Recycling of eIF2:GDP 8 3.52e-01 1.90e-01 7.18e-01
Signaling by NODAL 20 1.42e-01 -1.90e-01 5.35e-01
Anchoring fibril formation 15 2.04e-01 -1.89e-01 6.08e-01
Telomere C-strand synthesis initiation 13 2.38e-01 1.89e-01 6.37e-01
Adrenoceptors 9 3.26e-01 1.89e-01 7.07e-01
Pre-NOTCH Transcription and Translation 68 7.07e-03 -1.89e-01 1.58e-01
Platelet Aggregation (Plug Formation) 39 4.18e-02 -1.88e-01 3.61e-01
Phosphorylation of the APC/C 20 1.45e-01 1.88e-01 5.42e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 2.60e-01 -1.88e-01 6.53e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 1.91e-02 1.88e-01 2.47e-01
APC/C-mediated degradation of cell cycle proteins 88 2.33e-03 1.88e-01 9.74e-02
Regulation of mitotic cell cycle 88 2.33e-03 1.88e-01 9.74e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 2.41e-01 1.88e-01 6.40e-01
Electric Transmission Across Gap Junctions 5 4.69e-01 1.87e-01 7.95e-01
Transmission across Electrical Synapses 5 4.69e-01 1.87e-01 7.95e-01
Signalling to ERKs 34 5.94e-02 -1.87e-01 3.90e-01
Glucagon signaling in metabolic regulation 32 6.74e-02 -1.87e-01 4.07e-01
Regulation of CDH11 gene transcription 10 3.06e-01 -1.87e-01 6.93e-01
Regulation of APC/C activators between G1/S and early anaphase 81 3.66e-03 1.87e-01 1.07e-01
Alpha-protein kinase 1 signaling pathway 11 2.84e-01 1.87e-01 6.76e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 2.84e-01 1.87e-01 6.76e-01
DNA Damage Reversal 8 3.61e-01 -1.86e-01 7.30e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.01e-01 -1.86e-01 4.79e-01
Interleukin-2 family signaling 40 4.22e-02 -1.86e-01 3.61e-01
VLDL assembly 5 4.72e-01 -1.86e-01 7.97e-01
SCF-beta-TrCP mediated degradation of Emi1 55 1.76e-02 1.85e-01 2.36e-01
Modulation by Mtb of host immune system 6 4.33e-01 1.85e-01 7.77e-01
TP53 Regulates Transcription of Cell Death Genes 44 3.38e-02 -1.85e-01 3.22e-01
NOSTRIN mediated eNOS trafficking 5 4.75e-01 1.85e-01 7.99e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 39 4.63e-02 -1.84e-01 3.67e-01
Peroxisomal lipid metabolism 29 8.60e-02 -1.84e-01 4.50e-01
Aspirin ADME 41 4.14e-02 1.84e-01 3.60e-01
Opsins 8 3.67e-01 -1.84e-01 7.39e-01
Chemokine receptors bind chemokines 56 1.73e-02 1.84e-01 2.36e-01
Vpu mediated degradation of CD4 52 2.18e-02 1.84e-01 2.66e-01
P2Y receptors 12 2.70e-01 -1.84e-01 6.68e-01
p53-Dependent G1 DNA Damage Response 65 1.05e-02 1.84e-01 1.93e-01
p53-Dependent G1/S DNA damage checkpoint 65 1.05e-02 1.84e-01 1.93e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.11e-02 1.84e-01 1.96e-01
Non-integrin membrane-ECM interactions 59 1.51e-02 -1.83e-01 2.24e-01
Degradation of DVL 57 1.71e-02 1.83e-01 2.36e-01
Formation of the posterior neural plate 10 3.18e-01 1.82e-01 7.03e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 2.97e-01 -1.82e-01 6.84e-01
Nucleotide-like (purinergic) receptors 16 2.09e-01 -1.81e-01 6.14e-01
Digestion of dietary lipid 7 4.07e-01 1.81e-01 7.67e-01
Melanin biosynthesis 5 4.85e-01 1.80e-01 8.03e-01
Death Receptor Signaling 154 1.13e-04 -1.80e-01 1.43e-02
RHOB GTPase cycle 69 9.69e-03 -1.80e-01 1.87e-01
Cell recruitment (pro-inflammatory response) 26 1.12e-01 -1.80e-01 4.95e-01
Purinergic signaling in leishmaniasis infection 26 1.12e-01 -1.80e-01 4.95e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.11e-02 -1.80e-01 2.66e-01
PI3K/AKT activation 9 3.50e-01 -1.80e-01 7.17e-01
Dectin-2 family 28 9.97e-02 1.80e-01 4.77e-01
Signaling by cytosolic FGFR1 fusion mutants 18 1.88e-01 -1.79e-01 6.01e-01
Neurofascin interactions 7 4.13e-01 1.79e-01 7.67e-01
RHO GTPases Activate ROCKs 19 1.78e-01 -1.79e-01 5.92e-01
Phenylalanine and tyrosine metabolism 11 3.05e-01 -1.79e-01 6.91e-01
NRAGE signals death through JNK 58 1.86e-02 -1.79e-01 2.43e-01
RIP-mediated NFkB activation via ZBP1 17 2.04e-01 -1.78e-01 6.08e-01
VEGFA-VEGFR2 Pathway 97 2.49e-03 -1.78e-01 9.74e-02
Signaling by ERBB2 ECD mutants 16 2.19e-01 -1.78e-01 6.26e-01
GRB2 events in ERBB2 signaling 16 2.19e-01 -1.77e-01 6.26e-01
DNA replication initiation 8 3.85e-01 1.77e-01 7.51e-01
Advanced glycosylation endproduct receptor signaling 13 2.69e-01 -1.77e-01 6.68e-01
Cross-presentation of soluble exogenous antigens (endosomes) 48 3.45e-02 1.76e-01 3.25e-01
Nicotinate metabolism 31 8.95e-02 -1.76e-01 4.58e-01
Growth hormone receptor signaling 24 1.36e-01 -1.76e-01 5.25e-01
Loss of Function of TGFBR1 in Cancer 7 4.22e-01 1.75e-01 7.69e-01
Activation of BH3-only proteins 30 9.67e-02 -1.75e-01 4.74e-01
EGFR downregulation 31 9.16e-02 -1.75e-01 4.63e-01
Signaling by EGFR in Cancer 25 1.31e-01 -1.75e-01 5.13e-01
Extra-nuclear estrogen signaling 75 8.99e-03 -1.74e-01 1.79e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 60 1.96e-02 -1.74e-01 2.51e-01
Leading Strand Synthesis 14 2.59e-01 1.74e-01 6.53e-01
Polymerase switching 14 2.59e-01 1.74e-01 6.53e-01
Dopamine Neurotransmitter Release Cycle 23 1.49e-01 1.74e-01 5.49e-01
ABC transporter disorders 78 7.91e-03 1.74e-01 1.67e-01
Metabolism of Angiotensinogen to Angiotensins 18 2.03e-01 1.73e-01 6.08e-01
Cross-presentation of particulate exogenous antigens (phagosomes) 8 3.96e-01 -1.73e-01 7.55e-01
RUNX1 regulates transcription of genes involved in interleukin signaling 5 5.03e-01 1.73e-01 8.13e-01
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 6 4.63e-01 1.73e-01 7.94e-01
Reversal of alkylation damage by DNA dioxygenases 7 4.29e-01 -1.73e-01 7.75e-01
Endosomal/Vacuolar pathway 12 3.01e-01 -1.72e-01 6.87e-01
Calcitonin-like ligand receptors 10 3.46e-01 1.72e-01 7.15e-01
BBSome-mediated cargo-targeting to cilium 23 1.53e-01 1.72e-01 5.54e-01
NFE2L2 regulates pentose phosphate pathway genes 8 4.01e-01 -1.71e-01 7.62e-01
Apoptotic factor-mediated response 19 1.96e-01 -1.71e-01 6.07e-01
SHC1 events in ERBB2 signaling 22 1.65e-01 -1.71e-01 5.78e-01
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 10 3.49e-01 1.71e-01 7.17e-01
Josephin domain DUBs 11 3.26e-01 1.71e-01 7.07e-01
Regulation of RUNX3 expression and activity 55 2.85e-02 1.71e-01 2.93e-01
Formation of the beta-catenin:TCF transactivating complex 55 2.86e-02 -1.71e-01 2.93e-01
NFE2L2 regulating ER-stress associated genes 5 5.09e-01 -1.70e-01 8.13e-01
Prostacyclin signalling through prostacyclin receptor 19 1.99e-01 -1.70e-01 6.07e-01
GPER1 signaling 45 4.83e-02 -1.70e-01 3.69e-01
Interleukin receptor SHC signaling 24 1.49e-01 -1.70e-01 5.50e-01
Regulation of RUNX2 expression and activity 73 1.23e-02 1.69e-01 2.06e-01
FCERI mediated Ca+2 mobilization 31 1.03e-01 1.69e-01 4.85e-01
Sulfur amino acid metabolism 27 1.29e-01 -1.69e-01 5.13e-01
Interconversion of nucleotide di- and triphosphates 30 1.10e-01 -1.69e-01 4.93e-01
Activated NTRK2 signals through CDK5 6 4.75e-01 1.68e-01 7.99e-01
PKMTs methylate histone lysines 44 5.36e-02 -1.68e-01 3.87e-01
DARPP-32 events 24 1.54e-01 -1.68e-01 5.54e-01
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5 5.16e-01 -1.68e-01 8.15e-01
RMTs methylate histone arginines 44 5.44e-02 -1.68e-01 3.87e-01
p130Cas linkage to MAPK signaling for integrins 15 2.62e-01 -1.67e-01 6.57e-01
Signaling by Activin 17 2.33e-01 -1.67e-01 6.31e-01
Voltage gated Potassium channels 43 5.82e-02 1.67e-01 3.90e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 20 1.97e-01 -1.67e-01 6.07e-01
Synthesis of DNA 121 1.54e-03 1.67e-01 8.01e-02
G1/S-Specific Transcription 29 1.22e-01 1.66e-01 5.02e-01
Phase 4 - resting membrane potential 19 2.11e-01 1.66e-01 6.17e-01
RET signaling 41 6.66e-02 -1.66e-01 4.06e-01
Signaling by VEGF 106 3.27e-03 -1.65e-01 1.01e-01
Beta oxidation of butanoyl-CoA to acetyl-CoA 5 5.23e-01 -1.65e-01 8.18e-01
RHOC GTPase cycle 72 1.60e-02 -1.64e-01 2.31e-01
VLDL clearance 6 4.86e-01 -1.64e-01 8.03e-01
CDC42 GTPase cycle 153 4.60e-04 -1.64e-01 4.02e-02
Vasopressin regulates renal water homeostasis via Aquaporins 43 6.28e-02 -1.64e-01 3.97e-01
Signal transduction by L1 21 1.94e-01 -1.64e-01 6.07e-01
Constitutive Signaling by EGFRvIII 15 2.72e-01 -1.64e-01 6.68e-01
Signaling by EGFRvIII in Cancer 15 2.72e-01 -1.64e-01 6.68e-01
Beta-catenin phosphorylation cascade 17 2.42e-01 -1.64e-01 6.40e-01
Mineralocorticoid biosynthesis 6 4.87e-01 1.64e-01 8.04e-01
PINK1-PRKN Mediated Mitophagy 21 1.95e-01 1.64e-01 6.07e-01
Wax and plasmalogen biosynthesis 7 4.54e-01 1.63e-01 7.88e-01
Trafficking of myristoylated proteins to the cilium 5 5.29e-01 1.63e-01 8.20e-01
Signaling by Leptin 11 3.50e-01 -1.63e-01 7.17e-01
Plasma lipoprotein assembly, remodeling, and clearance 75 1.49e-02 -1.63e-01 2.23e-01
Acetylcholine binding and downstream events 14 2.92e-01 1.63e-01 6.82e-01
Postsynaptic nicotinic acetylcholine receptors 14 2.92e-01 1.63e-01 6.82e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 3.73e-01 -1.63e-01 7.44e-01
Thromboxane signalling through TP receptor 24 1.68e-01 -1.62e-01 5.84e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 55 3.73e-02 1.62e-01 3.36e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 37 8.76e-02 -1.62e-01 4.51e-01
Degradation of GLI1 by the proteasome 60 2.97e-02 1.62e-01 2.97e-01
G alpha (12/13) signalling events 79 1.29e-02 -1.62e-01 2.09e-01
ERBB2 Regulates Cell Motility 15 2.81e-01 -1.61e-01 6.74e-01
Signaling by NOTCH3 49 5.15e-02 -1.61e-01 3.79e-01
FGFR1b ligand binding and activation 8 4.32e-01 -1.60e-01 7.77e-01
Mitotic Telophase/Cytokinesis 13 3.17e-01 1.60e-01 7.03e-01
Assembly of active LPL and LIPC lipase complexes 19 2.27e-01 -1.60e-01 6.26e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 15 2.83e-01 1.60e-01 6.76e-01
RUNX3 Regulates Immune Response and Cell Migration 6 4.97e-01 1.60e-01 8.12e-01
Glycerophospholipid biosynthesis 126 1.95e-03 -1.60e-01 9.51e-02
Caspase activation via extrinsic apoptotic signalling pathway 26 1.59e-01 -1.60e-01 5.63e-01
Activated NTRK3 signals through RAS 8 4.35e-01 1.60e-01 7.77e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.07e-01 1.59e-01 6.09e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.07e-01 1.59e-01 6.09e-01
Tryptophan catabolism 14 3.03e-01 -1.59e-01 6.89e-01
Signaling by PDGF 58 3.64e-02 -1.59e-01 3.33e-01
PTK6 Regulates Proteins Involved in RNA Processing 5 5.39e-01 1.59e-01 8.24e-01
Purine catabolism 17 2.57e-01 -1.59e-01 6.51e-01
RAF-independent MAPK1/3 activation 23 1.88e-01 -1.59e-01 6.01e-01
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 58 3.70e-02 -1.58e-01 3.35e-01
Interleukin-15 signaling 14 3.06e-01 -1.58e-01 6.93e-01
WNT5A-dependent internalization of FZD4 15 2.90e-01 -1.58e-01 6.80e-01
Uptake and function of anthrax toxins 11 3.65e-01 -1.58e-01 7.37e-01
ADP signalling through P2Y purinoceptor 1 25 1.73e-01 -1.58e-01 5.90e-01
Incretin synthesis, secretion, and inactivation 24 1.82e-01 1.58e-01 5.96e-01
FGFR2 alternative splicing 26 1.65e-01 -1.57e-01 5.78e-01
Rab regulation of trafficking 121 2.85e-03 -1.57e-01 9.74e-02
Organic cation/anion/zwitterion transport 15 2.93e-01 -1.57e-01 6.82e-01
Erythropoietin activates Phospholipase C gamma (PLCG) 7 4.73e-01 -1.57e-01 7.97e-01
Ethanol oxidation 12 3.48e-01 1.57e-01 7.17e-01
Organic anion transporters 10 3.93e-01 -1.56e-01 7.54e-01
Signalling to RAS 20 2.28e-01 -1.56e-01 6.26e-01
Insulin processing 25 1.78e-01 1.56e-01 5.92e-01
Laminin interactions 30 1.40e-01 -1.56e-01 5.33e-01
Cohesin Loading onto Chromatin 10 3.94e-01 1.56e-01 7.54e-01
Neurotransmitter release cycle 51 5.48e-02 1.55e-01 3.87e-01
MET promotes cell motility 41 8.51e-02 -1.55e-01 4.50e-01
Formation of WDR5-containing histone-modifying complexes 41 8.53e-02 -1.55e-01 4.50e-01
DCC mediated attractive signaling 14 3.17e-01 -1.55e-01 7.03e-01
Acrosome Reaction and Sperm:Oocyte Membrane Binding 6 5.12e-01 1.54e-01 8.15e-01
Interleukin-6 signaling 11 3.77e-01 -1.54e-01 7.47e-01
The retinoid cycle in cones (daylight vision) 6 5.15e-01 -1.54e-01 8.15e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 1.84e-01 -1.53e-01 5.99e-01
Signaling by MET 79 1.85e-02 -1.53e-01 2.43e-01
FOXO-mediated transcription of cell cycle genes 17 2.74e-01 1.53e-01 6.70e-01
Signaling by ERBB2 50 6.14e-02 -1.53e-01 3.93e-01
Nitric oxide stimulates guanylate cyclase 21 2.26e-01 1.53e-01 6.26e-01
Initial triggering of complement 22 2.16e-01 -1.52e-01 6.20e-01
Activated NTRK2 signals through PI3K 7 4.86e-01 1.52e-01 8.03e-01
Hedgehog ligand biogenesis 65 3.42e-02 1.52e-01 3.25e-01
MECP2 regulates neuronal receptors and channels 18 2.65e-01 1.52e-01 6.62e-01
Ca-dependent events 37 1.10e-01 -1.52e-01 4.93e-01
Lipid particle organization 6 5.21e-01 1.51e-01 8.18e-01
RND2 GTPase cycle 42 9.03e-02 -1.51e-01 4.60e-01
Digestion 19 2.54e-01 1.51e-01 6.48e-01
DAG and IP3 signaling 41 9.46e-02 -1.51e-01 4.69e-01
GLI3 is processed to GLI3R by the proteasome 60 4.34e-02 1.51e-01 3.65e-01
GABA synthesis, release, reuptake and degradation 19 2.57e-01 1.50e-01 6.51e-01
Regulation of ornithine decarboxylase (ODC) 51 6.34e-02 1.50e-01 3.97e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 65 3.67e-02 1.50e-01 3.34e-01
Zinc influx into cells by the SLC39 gene family 10 4.12e-01 -1.50e-01 7.67e-01
Interleukin-18 signaling 8 4.63e-01 -1.50e-01 7.94e-01
Nuclear Events (kinase and transcription factor activation) 61 4.31e-02 1.50e-01 3.65e-01
Cargo concentration in the ER 33 1.37e-01 -1.50e-01 5.25e-01
Downregulation of ERBB4 signaling 9 4.37e-01 1.49e-01 7.77e-01
Synthesis of UDP-N-acetyl-glucosamine 8 4.65e-01 1.49e-01 7.95e-01
Regulation of PTEN stability and activity 69 3.22e-02 1.49e-01 3.16e-01
RHOF GTPase cycle 42 9.48e-02 -1.49e-01 4.69e-01
POLB-Dependent Long Patch Base Excision Repair 8 4.66e-01 1.49e-01 7.95e-01
G0 and Early G1 27 1.81e-01 1.49e-01 5.96e-01
Signaling by ERBB2 KD Mutants 25 1.99e-01 -1.48e-01 6.07e-01
Activation of the AP-1 family of transcription factors 10 4.17e-01 1.48e-01 7.68e-01
Cell-Cell communication 153 1.55e-03 -1.48e-01 8.01e-02
FLT3 Signaling 38 1.14e-01 -1.48e-01 4.97e-01
Gain-of-function MRAS complexes activate RAF signaling 8 4.68e-01 -1.48e-01 7.95e-01
SHOC2 M1731 mutant abolishes MRAS complex function 8 4.68e-01 -1.48e-01 7.95e-01
Signaling by MRAS-complex mutants 8 4.68e-01 -1.48e-01 7.95e-01
RNA Polymerase I Promoter Opening 26 1.91e-01 -1.48e-01 6.06e-01
RHOA GTPase cycle 147 1.99e-03 -1.48e-01 9.51e-02
RND1 GTPase cycle 42 9.78e-02 -1.48e-01 4.75e-01
Degradation of GLI2 by the proteasome 60 4.84e-02 1.47e-01 3.69e-01
Collagen formation 90 1.58e-02 -1.47e-01 2.31e-01
G beta:gamma signalling through PI3Kgamma 25 2.04e-01 -1.47e-01 6.08e-01
E2F mediated regulation of DNA replication 21 2.45e-01 1.46e-01 6.42e-01
NIK–>noncanonical NF-kB signaling 59 5.21e-02 1.46e-01 3.80e-01
The canonical retinoid cycle in rods (twilight vision) 23 2.25e-01 -1.46e-01 6.26e-01
Condensation of Prophase Chromosomes 37 1.25e-01 -1.46e-01 5.12e-01
Signaling by BRAF and RAF1 fusions 65 4.24e-02 -1.46e-01 3.61e-01
Condensation of Prometaphase Chromosomes 11 4.03e-01 1.46e-01 7.64e-01
Somitogenesis 55 6.21e-02 1.45e-01 3.96e-01
RAB GEFs exchange GTP for GDP on RABs 88 1.84e-02 -1.45e-01 2.43e-01
Phase 0 - rapid depolarisation 32 1.55e-01 1.45e-01 5.54e-01
Interleukin-2 signaling 12 3.84e-01 -1.45e-01 7.51e-01
ERKs are inactivated 13 3.65e-01 -1.45e-01 7.37e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 42 1.04e-01 -1.45e-01 4.86e-01
RHOBTB1 GTPase cycle 23 2.32e-01 1.44e-01 6.31e-01
Activation of HOX genes during differentiation 85 2.21e-02 -1.44e-01 2.66e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 85 2.21e-02 -1.44e-01 2.66e-01
Interaction between L1 and Ankyrins 31 1.67e-01 1.44e-01 5.81e-01
Neurotoxicity of clostridium toxins 10 4.32e-01 1.44e-01 7.77e-01
Ephrin signaling 19 2.79e-01 -1.43e-01 6.74e-01
Synaptic adhesion-like molecules 21 2.56e-01 -1.43e-01 6.51e-01
Scavenging by Class F Receptors 6 5.44e-01 1.43e-01 8.30e-01
HDACs deacetylate histones 58 5.94e-02 -1.43e-01 3.90e-01
Downregulation of ERBB2:ERBB3 signaling 13 3.73e-01 -1.43e-01 7.44e-01
MAPK6/MAPK4 signaling 92 1.81e-02 1.43e-01 2.41e-01
Signaling by FGFR1 in disease 38 1.29e-01 -1.42e-01 5.13e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 58 6.05e-02 -1.42e-01 3.90e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 58 6.05e-02 -1.42e-01 3.90e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 58 6.05e-02 -1.42e-01 3.90e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 58 6.05e-02 -1.42e-01 3.90e-01
Signaling by NOTCH1 in Cancer 58 6.05e-02 -1.42e-01 3.90e-01
ADORA2B mediated anti-inflammatory cytokines production 43 1.06e-01 -1.42e-01 4.89e-01
Collagen biosynthesis and modifying enzymes 67 4.43e-02 -1.42e-01 3.67e-01
Regulation of NF-kappa B signaling 18 2.97e-01 -1.42e-01 6.84e-01
FCERI mediated NF-kB activation 81 2.72e-02 1.42e-01 2.90e-01
Response of EIF2AK1 (HRI) to heme deficiency 15 3.41e-01 1.42e-01 7.12e-01
Proton-coupled monocarboxylate transport 6 5.48e-01 -1.42e-01 8.30e-01
CaM pathway 35 1.48e-01 -1.41e-01 5.46e-01
Calmodulin induced events 35 1.48e-01 -1.41e-01 5.46e-01
Transcriptional activation of mitochondrial biogenesis 53 7.50e-02 -1.41e-01 4.28e-01
Signaling by FLT3 ITD and TKD mutants 16 3.28e-01 -1.41e-01 7.07e-01
Digestion and absorption 24 2.31e-01 1.41e-01 6.31e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 2.04e-01 1.41e-01 6.08e-01
Regulated Necrosis 58 6.35e-02 -1.41e-01 3.97e-01
Dectin-1 mediated noncanonical NF-kB signaling 62 5.62e-02 1.40e-01 3.90e-01
Activated NTRK2 signals through FYN 7 5.21e-01 1.40e-01 8.18e-01
Heme signaling 46 1.01e-01 -1.40e-01 4.79e-01
Cyclin E associated events during G1/S transition 83 2.77e-02 1.40e-01 2.90e-01
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 8 4.94e-01 1.40e-01 8.10e-01
MET activates PTK2 signaling 30 1.86e-01 -1.39e-01 6.01e-01
Digestion of dietary carbohydrate 7 5.23e-01 1.39e-01 8.18e-01
Signaling by Hippo 20 2.81e-01 -1.39e-01 6.75e-01
Apoptotic cleavage of cellular proteins 38 1.38e-01 -1.39e-01 5.27e-01
Signaling by WNT in cancer 34 1.61e-01 -1.39e-01 5.67e-01
RAB geranylgeranylation 64 5.47e-02 -1.39e-01 3.87e-01
Signaling by FLT3 fusion proteins 19 2.95e-01 -1.39e-01 6.84e-01
G1/S Transition 130 6.36e-03 1.39e-01 1.50e-01
Nonhomologous End-Joining (NHEJ) 47 1.00e-01 -1.39e-01 4.79e-01
Methionine salvage pathway 6 5.57e-01 -1.39e-01 8.33e-01
Methylation 14 3.70e-01 1.38e-01 7.40e-01
Tachykinin receptors bind tachykinins 5 5.92e-01 1.38e-01 8.56e-01
Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10 4.49e-01 -1.38e-01 7.86e-01
Phase I - Functionalization of compounds 105 1.45e-02 1.38e-01 2.22e-01
Formation of tubulin folding intermediates by CCT/TriC 25 2.33e-01 1.38e-01 6.31e-01
Assembly of collagen fibrils and other multimeric structures 61 6.29e-02 -1.38e-01 3.97e-01
RHO GTPases activate PKNs 57 7.27e-02 -1.37e-01 4.25e-01
Vitamin B1 (thiamin) metabolism 5 5.96e-01 1.37e-01 8.57e-01
AKT phosphorylates targets in the cytosol 14 3.76e-01 -1.37e-01 7.47e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 3.94e-01 -1.37e-01 7.54e-01
Negative regulation of NOTCH4 signaling 54 8.29e-02 1.36e-01 4.50e-01
RNA Polymerase I Transcription Termination 29 2.05e-01 1.36e-01 6.08e-01
Regulation of MECP2 expression and activity 32 1.83e-01 -1.36e-01 5.98e-01
InlA-mediated entry of Listeria monocytogenes into host cells 9 4.80e-01 -1.36e-01 8.02e-01
Phospholipid metabolism 208 7.31e-04 -1.36e-01 5.45e-02
Regulation of TP53 Expression and Degradation 37 1.54e-01 -1.35e-01 5.54e-01
Class I peroxisomal membrane protein import 20 2.95e-01 1.35e-01 6.84e-01
Interferon alpha/beta signaling 72 4.72e-02 -1.35e-01 3.68e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 4.59e-01 -1.35e-01 7.92e-01
Signaling by ERBB2 TMD/JMD mutants 22 2.73e-01 -1.35e-01 6.69e-01
Formation of ATP by chemiosmotic coupling 16 3.50e-01 1.35e-01 7.17e-01
Unwinding of DNA 12 4.18e-01 1.35e-01 7.69e-01
RUNX3 regulates CDKN1A transcription 7 5.38e-01 -1.34e-01 8.24e-01
SHC-related events triggered by IGF1R 9 4.85e-01 -1.34e-01 8.03e-01
EPH-ephrin mediated repulsion of cells 51 9.70e-02 -1.34e-01 4.74e-01
TRAF6 mediated NF-kB activation 25 2.46e-01 -1.34e-01 6.42e-01
UCH proteinases 96 2.32e-02 1.34e-01 2.73e-01
COPII-mediated vesicle transport 68 5.61e-02 -1.34e-01 3.90e-01
S Phase 163 3.19e-03 1.34e-01 1.00e-01
PI3K events in ERBB4 signaling 10 4.65e-01 -1.33e-01 7.95e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 3.27e-01 -1.33e-01 7.07e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30 2.06e-01 -1.33e-01 6.09e-01
Beta oxidation of hexanoyl-CoA to butanoyl-CoA 5 6.06e-01 -1.33e-01 8.62e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.89e-01 1.33e-01 7.52e-01
p75 NTR receptor-mediated signalling 97 2.36e-02 -1.33e-01 2.76e-01
Regulation of RAS by GAPs 67 5.99e-02 1.33e-01 3.90e-01
PLC beta mediated events 49 1.09e-01 -1.32e-01 4.92e-01
Chromatin modifying enzymes 229 5.93e-04 -1.32e-01 4.77e-02
Chromatin organization 229 5.93e-04 -1.32e-01 4.77e-02
Beta-oxidation of pristanoyl-CoA 9 4.94e-01 -1.32e-01 8.10e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.45e-01 1.32e-01 5.42e-01
Diseases of DNA Double-Strand Break Repair 41 1.45e-01 1.32e-01 5.42e-01
Cell-cell junction organization 90 3.27e-02 -1.30e-01 3.18e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 4.55e-01 -1.30e-01 7.88e-01
Cell death signalling via NRAGE, NRIF and NADE 75 5.13e-02 -1.30e-01 3.79e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 3.53e-01 -1.30e-01 7.19e-01
Inflammasomes 21 3.02e-01 -1.30e-01 6.89e-01
G-protein activation 24 2.72e-01 -1.30e-01 6.68e-01
Heparan sulfate/heparin (HS-GAG) metabolism 57 9.18e-02 -1.29e-01 4.63e-01
Prevention of phagosomal-lysosomal fusion 9 5.03e-01 1.29e-01 8.13e-01
Germ layer formation at gastrulation 16 3.72e-01 1.29e-01 7.42e-01
Detoxification of Reactive Oxygen Species 36 1.82e-01 -1.29e-01 5.96e-01
Regulation of lipid metabolism by PPARalpha 118 1.58e-02 -1.29e-01 2.31e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.81e-01 1.29e-01 8.03e-01
Zygotic genome activation (ZGA) 13 4.22e-01 1.29e-01 7.69e-01
PPARA activates gene expression 116 1.69e-02 -1.28e-01 2.36e-01
Aquaporin-mediated transport 52 1.09e-01 -1.28e-01 4.93e-01
Gluconeogenesis 35 1.91e-01 -1.28e-01 6.05e-01
RAC1 GTPase cycle 183 2.88e-03 -1.28e-01 9.74e-02
PKA-mediated phosphorylation of CREB 20 3.23e-01 -1.28e-01 7.07e-01
Keratinization 207 1.55e-03 1.28e-01 8.01e-02
Regulation of PTEN localization 9 5.08e-01 1.28e-01 8.13e-01
Hyaluronan biosynthesis and export 5 6.22e-01 -1.27e-01 8.63e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 4.09e-01 -1.27e-01 7.67e-01
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 5 6.22e-01 -1.27e-01 8.63e-01
TRAIL signaling 8 5.33e-01 -1.27e-01 8.21e-01
Nuclear signaling by ERBB4 32 2.12e-01 -1.27e-01 6.18e-01
Synthesis of very long-chain fatty acyl-CoAs 24 2.80e-01 1.27e-01 6.74e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 77 5.44e-02 1.27e-01 3.87e-01
Diseases of DNA repair 51 1.17e-01 1.27e-01 5.00e-01
The NLRP3 inflammasome 16 3.80e-01 -1.27e-01 7.48e-01
Signaling by Nuclear Receptors 267 3.75e-04 -1.26e-01 3.42e-02
Peptide hormone metabolism 86 4.27e-02 1.26e-01 3.63e-01
Unblocking of NMDA receptors, glutamate binding and activation 21 3.16e-01 1.26e-01 7.03e-01
ABC-family proteins mediated transport 103 2.74e-02 1.26e-01 2.90e-01
Basigin interactions 25 2.77e-01 -1.26e-01 6.73e-01
Signaling by SCF-KIT 43 1.55e-01 -1.25e-01 5.54e-01
Activation of NF-kappaB in B cells 67 7.62e-02 1.25e-01 4.31e-01
NCAM signaling for neurite out-growth 63 8.57e-02 -1.25e-01 4.50e-01
Purine ribonucleoside monophosphate biosynthesis 9 5.16e-01 1.25e-01 8.15e-01
Heme biosynthesis 14 4.18e-01 1.25e-01 7.69e-01
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.72e-01 1.25e-01 5.89e-01
Acetylcholine regulates insulin secretion 10 4.94e-01 -1.25e-01 8.10e-01
mRNA Capping 28 2.54e-01 1.25e-01 6.48e-01
RUNX3 regulates NOTCH signaling 14 4.22e-01 -1.24e-01 7.69e-01
Chondroitin sulfate/dermatan sulfate metabolism 50 1.30e-01 -1.24e-01 5.13e-01
Erythrocytes take up carbon dioxide and release oxygen 12 4.58e-01 -1.24e-01 7.92e-01
O2/CO2 exchange in erythrocytes 12 4.58e-01 -1.24e-01 7.92e-01
G-protein mediated events 54 1.16e-01 -1.23e-01 5.00e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 4.24e-01 -1.23e-01 7.69e-01
Synthesis of PE 13 4.42e-01 -1.23e-01 7.80e-01
FGFR1 mutant receptor activation 31 2.35e-01 -1.23e-01 6.34e-01
RAC2 GTPase cycle 88 4.58e-02 -1.23e-01 3.67e-01
Regulation of innate immune responses to cytosolic DNA 15 4.09e-01 1.23e-01 7.67e-01
Signaling by FGFR3 40 1.79e-01 -1.23e-01 5.94e-01
SUMOylation of transcription factors 20 3.42e-01 1.23e-01 7.12e-01
Integration of energy metabolism 107 2.88e-02 -1.22e-01 2.93e-01
RHOQ GTPase cycle 59 1.05e-01 -1.22e-01 4.87e-01
Toxicity of botulinum toxin type D (botD) 5 6.36e-01 1.22e-01 8.72e-01
Toxicity of botulinum toxin type F (botF) 5 6.36e-01 1.22e-01 8.72e-01
Metabolism of carbohydrates 298 2.87e-04 -1.22e-01 2.88e-02
PCNA-Dependent Long Patch Base Excision Repair 21 3.33e-01 1.22e-01 7.12e-01
Cyclin A:Cdk2-associated events at S phase entry 85 5.22e-02 1.22e-01 3.80e-01
TRAF3-dependent IRF activation pathway 15 4.15e-01 -1.22e-01 7.67e-01
Unfolded Protein Response (UPR) 89 4.75e-02 -1.21e-01 3.68e-01
RNA Pol II CTD phosphorylation and interaction with CE 26 2.84e-01 1.21e-01 6.76e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 26 2.84e-01 1.21e-01 6.76e-01
ESR-mediated signaling 187 4.20e-03 -1.21e-01 1.15e-01
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 5 6.39e-01 -1.21e-01 8.74e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 101 3.54e-02 1.21e-01 3.27e-01
Abacavir ADME 9 5.30e-01 1.21e-01 8.21e-01
Glycosphingolipid metabolism 58 1.11e-01 -1.21e-01 4.95e-01
Impaired BRCA2 binding to RAD51 35 2.17e-01 1.21e-01 6.22e-01
Mitotic G1 phase and G1/S transition 148 1.14e-02 1.21e-01 1.97e-01
DNA Replication 151 1.09e-02 1.20e-01 1.95e-01
Signaling by MAPK mutants 7 5.83e-01 1.20e-01 8.49e-01
Removal of the Flap Intermediate from the C-strand 17 3.93e-01 1.20e-01 7.54e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.94e-01 -1.20e-01 7.54e-01
MET Receptor Activation 6 6.12e-01 -1.19e-01 8.63e-01
DNA Replication Pre-Initiation 123 2.27e-02 1.19e-01 2.68e-01
G2/M Checkpoints 146 1.33e-02 1.19e-01 2.13e-01
Activated NTRK3 signals through PI3K 6 6.16e-01 -1.18e-01 8.63e-01
Glucose metabolism 94 4.75e-02 -1.18e-01 3.68e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.45e-01 1.18e-01 7.83e-01
Pexophagy 10 5.19e-01 1.18e-01 8.18e-01
Metabolism of nucleotides 96 4.62e-02 -1.18e-01 3.67e-01
Mitochondrial iron-sulfur cluster biogenesis 13 4.63e-01 1.18e-01 7.94e-01
Assembly and cell surface presentation of NMDA receptors 42 1.87e-01 1.18e-01 6.01e-01
Signaling by ERBB2 in Cancer 26 3.00e-01 -1.17e-01 6.86e-01
Muscarinic acetylcholine receptors 5 6.49e-01 -1.17e-01 8.75e-01
Opioid Signalling 90 5.45e-02 -1.17e-01 3.87e-01
TAK1-dependent IKK and NF-kappa-B activation 44 1.79e-01 -1.17e-01 5.94e-01
FCGR3A-mediated phagocytosis 59 1.20e-01 -1.17e-01 5.00e-01
Leishmania phagocytosis 59 1.20e-01 -1.17e-01 5.00e-01
Parasite infection 59 1.20e-01 -1.17e-01 5.00e-01
Metabolism of polyamines 59 1.20e-01 1.17e-01 5.00e-01
Downstream TCR signaling 95 4.91e-02 1.17e-01 3.70e-01
Signaling by FGFR3 in disease 22 3.43e-01 -1.17e-01 7.12e-01
Transcriptional Regulation by VENTX 41 1.97e-01 -1.16e-01 6.07e-01
Processing and activation of SUMO 10 5.24e-01 1.16e-01 8.18e-01
Regulation of TP53 Degradation 36 2.27e-01 -1.16e-01 6.26e-01
Hyaluronan metabolism 17 4.07e-01 -1.16e-01 7.67e-01
Diseases associated with glycosaminoglycan metabolism 41 1.98e-01 -1.16e-01 6.07e-01
Transcription of E2F targets under negative control by DREAM complex 19 3.83e-01 1.16e-01 7.51e-01
SRP-dependent cotranslational protein targeting to membrane 112 3.51e-02 1.15e-01 3.27e-01
Aflatoxin activation and detoxification 19 3.84e-01 -1.15e-01 7.51e-01
Activation of NOXA and translocation to mitochondria 5 6.56e-01 -1.15e-01 8.76e-01
GLI proteins bind promoters of Hh responsive genes to promote transcription 7 5.99e-01 -1.15e-01 8.57e-01
Apoptotic execution phase 52 1.53e-01 -1.15e-01 5.54e-01
RND3 GTPase cycle 42 1.99e-01 -1.14e-01 6.07e-01
MyD88 dependent cascade initiated on endosome 102 4.62e-02 -1.14e-01 3.67e-01
Keratan sulfate degradation 15 4.44e-01 -1.14e-01 7.82e-01
N-glycan trimming and elongation in the cis-Golgi 5 6.59e-01 1.14e-01 8.78e-01
Specification of primordial germ cells 11 5.13e-01 -1.14e-01 8.15e-01
Polymerase switching on the C-strand of the telomere 26 3.14e-01 1.14e-01 7.03e-01
Butyrophilin (BTN) family interactions 12 4.94e-01 -1.14e-01 8.10e-01
Viral mRNA Translation 89 6.34e-02 1.14e-01 3.97e-01
Homologous DNA Pairing and Strand Exchange 43 1.97e-01 1.14e-01 6.07e-01
Glycosaminoglycan metabolism 126 2.75e-02 -1.14e-01 2.90e-01
Removal of the Flap Intermediate 14 4.61e-01 1.14e-01 7.94e-01
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 8 5.79e-01 -1.13e-01 8.48e-01
Regulation of FZD by ubiquitination 21 3.68e-01 1.13e-01 7.39e-01
Signaling by ALK fusions and activated point mutants 93 5.88e-02 -1.13e-01 3.90e-01
Signaling by ALK in cancer 93 5.88e-02 -1.13e-01 3.90e-01
RHO GTPase cycle 444 4.22e-05 -1.13e-01 6.06e-03
SARS-CoV-1 modulates host translation machinery 36 2.41e-01 1.13e-01 6.40e-01
Signaling by PDGFRA extracellular domain mutants 12 4.99e-01 -1.13e-01 8.12e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 4.99e-01 -1.13e-01 8.12e-01
TFAP2 (AP-2) family regulates transcription of cell cycle factors 5 6.63e-01 -1.13e-01 8.80e-01
Regulation of TP53 Activity through Phosphorylation 92 6.23e-02 1.12e-01 3.96e-01
Phenylalanine metabolism 6 6.34e-01 -1.12e-01 8.71e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 17 4.23e-01 -1.12e-01 7.69e-01
Defects in biotin (Btn) metabolism 8 5.83e-01 -1.12e-01 8.49e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.86e-01 1.12e-01 7.51e-01
Formation of paraxial mesoderm 69 1.09e-01 1.12e-01 4.92e-01
PRC2 methylates histones and DNA 36 2.46e-01 -1.12e-01 6.42e-01
Signaling by FGFR 89 6.87e-02 -1.12e-01 4.08e-01
Hyaluronan uptake and degradation 12 5.03e-01 -1.12e-01 8.13e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 4.40e-01 -1.12e-01 7.80e-01
Regulation of NPAS4 gene expression 13 4.86e-01 -1.12e-01 8.03e-01
DNA strand elongation 32 2.75e-01 1.12e-01 6.71e-01
Cation-coupled Chloride cotransporters 7 6.10e-01 1.11e-01 8.63e-01
Budding and maturation of HIV virion 28 3.10e-01 -1.11e-01 6.97e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 2.87e-01 -1.11e-01 6.77e-01
Downstream signaling events of B Cell Receptor (BCR) 81 8.60e-02 1.10e-01 4.50e-01
Regulation of expression of SLITs and ROBOs 171 1.29e-02 1.10e-01 2.09e-01
Negative regulation of the PI3K/AKT network 113 4.38e-02 -1.10e-01 3.67e-01
TNFs bind their physiological receptors 27 3.26e-01 -1.09e-01 7.07e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.50e-01 -1.09e-01 8.30e-01
Cholesterol biosynthesis 27 3.27e-01 -1.09e-01 7.07e-01
Translocation of ZAP-70 to Immunological synapse 17 4.37e-01 1.09e-01 7.77e-01
p75NTR negatively regulates cell cycle via SC1 6 6.44e-01 -1.09e-01 8.75e-01
Long-term potentiation 23 3.67e-01 1.09e-01 7.39e-01
Signalling to p38 via RIT and RIN 5 6.74e-01 1.09e-01 8.86e-01
Sema3A PAK dependent Axon repulsion 16 4.54e-01 -1.08e-01 7.88e-01
Metalloprotease DUBs 28 3.22e-01 1.08e-01 7.06e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 2.50e-01 1.08e-01 6.47e-01
Regulation of TLR by endogenous ligand 21 3.92e-01 1.08e-01 7.54e-01
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 8 5.97e-01 -1.08e-01 8.57e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 103 5.88e-02 -1.08e-01 3.90e-01
Keratan sulfate/keratin metabolism 36 2.63e-01 -1.08e-01 6.59e-01
Packaging Of Telomere Ends 29 3.18e-01 -1.07e-01 7.03e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 101 6.28e-02 -1.07e-01 3.97e-01
Toll Like Receptor 9 (TLR9) Cascade 106 5.66e-02 -1.07e-01 3.90e-01
Fcgamma receptor (FCGR) dependent phagocytosis 86 8.59e-02 -1.07e-01 4.50e-01
rRNA modification in the nucleus and cytosol 59 1.56e-01 1.07e-01 5.55e-01
NADE modulates death signalling 6 6.50e-01 -1.07e-01 8.75e-01
Response to metal ions 14 4.89e-01 -1.07e-01 8.04e-01
G alpha (z) signalling events 48 2.02e-01 -1.06e-01 6.08e-01
HDR through Single Strand Annealing (SSA) 37 2.65e-01 1.06e-01 6.62e-01
Formation of definitive endoderm 16 4.63e-01 -1.06e-01 7.94e-01
Acyl chain remodelling of PS 22 3.90e-01 -1.06e-01 7.53e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 44 2.25e-01 -1.06e-01 6.26e-01
Signaling by RAS mutants 44 2.25e-01 -1.06e-01 6.26e-01
Signaling by moderate kinase activity BRAF mutants 44 2.25e-01 -1.06e-01 6.26e-01
Signaling downstream of RAS mutants 44 2.25e-01 -1.06e-01 6.26e-01
Assembly of the pre-replicative complex 106 5.98e-02 1.06e-01 3.90e-01
Inactivation, recovery and regulation of the phototransduction cascade 33 2.94e-01 -1.06e-01 6.83e-01
Synthesis of PC 28 3.33e-01 -1.06e-01 7.12e-01
Synthesis of PIPs at the Golgi membrane 18 4.38e-01 1.06e-01 7.77e-01
Regulation of NPAS4 mRNA translation 9 5.84e-01 -1.05e-01 8.49e-01
Phase 3 - rapid repolarisation 9 5.84e-01 -1.05e-01 8.49e-01
Nucleotide catabolism 35 2.81e-01 -1.05e-01 6.74e-01
Defects in cobalamin (B12) metabolism 13 5.12e-01 1.05e-01 8.15e-01
PIWI-interacting RNA (piRNA) biogenesis 29 3.27e-01 1.05e-01 7.07e-01
RUNX2 regulates chondrocyte maturation 5 6.84e-01 1.05e-01 8.86e-01
Transport of vitamins, nucleosides, and related molecules 42 2.40e-01 -1.05e-01 6.39e-01
Regulation of CDH11 function 11 5.47e-01 -1.05e-01 8.30e-01
Acyl chain remodelling of PG 18 4.42e-01 -1.05e-01 7.80e-01
EPH-Ephrin signaling 92 8.31e-02 -1.05e-01 4.50e-01
Signaling by CSF3 (G-CSF) 30 3.22e-01 1.05e-01 7.06e-01
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 7 6.32e-01 -1.04e-01 8.69e-01
Glycogen breakdown (glycogenolysis) 14 4.99e-01 -1.04e-01 8.12e-01
Leishmania infection 162 2.19e-02 -1.04e-01 2.66e-01
Parasitic Infection Pathways 162 2.19e-02 -1.04e-01 2.66e-01
Phase 2 - plateau phase 15 4.84e-01 -1.04e-01 8.03e-01
Oncogenic MAPK signaling 81 1.05e-01 -1.04e-01 4.87e-01
Role of LAT2/NTAL/LAB on calcium mobilization 16 4.71e-01 1.04e-01 7.95e-01
Transport of organic anions 11 5.50e-01 1.04e-01 8.30e-01
Intestinal absorption 5 6.87e-01 1.04e-01 8.87e-01
Peptide chain elongation 89 9.07e-02 1.04e-01 4.60e-01
Signaling by RAF1 mutants 41 2.51e-01 -1.04e-01 6.47e-01
Plasma lipoprotein remodeling 34 2.96e-01 -1.04e-01 6.84e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 15 4.87e-01 -1.04e-01 8.04e-01
Signal amplification 33 3.03e-01 -1.04e-01 6.89e-01
FOXO-mediated transcription of cell death genes 16 4.74e-01 -1.03e-01 7.98e-01
HIV Transcription Initiation 46 2.26e-01 1.03e-01 6.26e-01
RNA Polymerase II HIV Promoter Escape 46 2.26e-01 1.03e-01 6.26e-01
RNA Polymerase II Promoter Escape 46 2.26e-01 1.03e-01 6.26e-01
RNA Polymerase II Transcription Initiation 46 2.26e-01 1.03e-01 6.26e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 46 2.26e-01 1.03e-01 6.26e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 46 2.26e-01 1.03e-01 6.26e-01
CaMK IV-mediated phosphorylation of CREB 10 5.72e-01 -1.03e-01 8.46e-01
Molecules associated with elastic fibres 37 2.78e-01 -1.03e-01 6.74e-01
Formation of intermediate mesoderm 8 6.14e-01 1.03e-01 8.63e-01
Kidney development 46 2.27e-01 1.03e-01 6.26e-01
Formation of Incision Complex in GG-NER 42 2.48e-01 1.03e-01 6.46e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.29e-01 1.03e-01 7.09e-01
Signaling by high-kinase activity BRAF mutants 36 2.86e-01 -1.03e-01 6.77e-01
Visual phototransduction 99 7.77e-02 -1.03e-01 4.35e-01
Eukaryotic Translation Termination 93 8.77e-02 1.02e-01 4.51e-01
Purine salvage 13 5.23e-01 1.02e-01 8.18e-01
Intrinsic Pathway of Fibrin Clot Formation 23 3.96e-01 -1.02e-01 7.55e-01
Generation of second messenger molecules 31 3.26e-01 1.02e-01 7.07e-01
Elastic fibre formation 44 2.42e-01 -1.02e-01 6.40e-01
Circadian Clock 67 1.49e-01 -1.02e-01 5.50e-01
Transcriptional regulation of testis differentiation 12 5.41e-01 -1.02e-01 8.27e-01
Pausing and recovery of Tat-mediated HIV elongation 31 3.27e-01 -1.02e-01 7.07e-01
Tat-mediated HIV elongation arrest and recovery 31 3.27e-01 -1.02e-01 7.07e-01
Adrenaline,noradrenaline inhibits insulin secretion 28 3.52e-01 -1.02e-01 7.18e-01
Separation of Sister Chromatids 188 1.63e-02 1.02e-01 2.32e-01
Organic cation transport 10 5.78e-01 -1.02e-01 8.48e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 115 6.03e-02 1.01e-01 3.90e-01
Defective CHST3 causes SEDCJD 8 6.20e-01 1.01e-01 8.63e-01
Spry regulation of FGF signaling 16 4.84e-01 -1.01e-01 8.03e-01
Miro GTPase Cycle 8 6.21e-01 -1.01e-01 8.63e-01
Cellular response to hypoxia 74 1.33e-01 1.01e-01 5.17e-01
Processing of SMDT1 14 5.14e-01 -1.01e-01 8.15e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 4.99e-01 -1.01e-01 8.12e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 4.99e-01 -1.01e-01 8.12e-01
The phototransduction cascade 34 3.10e-01 -1.01e-01 6.97e-01
STING mediated induction of host immune responses 16 4.86e-01 -1.01e-01 8.03e-01
Attachment of GPI anchor to uPAR 7 6.46e-01 -1.00e-01 8.75e-01
mTORC1-mediated signalling 24 3.96e-01 1.00e-01 7.55e-01
Peptide hormone biosynthesis 11 5.65e-01 1.00e-01 8.41e-01
Potential therapeutics for SARS 98 8.71e-02 -1.00e-01 4.51e-01
RUNX1 regulates expression of components of tight junctions 5 6.99e-01 -1.00e-01 8.90e-01
Insulin receptor signalling cascade 54 2.04e-01 -9.99e-02 6.08e-01
HS-GAG biosynthesis 31 3.36e-01 -9.98e-02 7.12e-01
Inactivation of CSF3 (G-CSF) signaling 25 3.88e-01 9.98e-02 7.51e-01
Abacavir transmembrane transport 5 6.99e-01 9.97e-02 8.90e-01
Suppression of phagosomal maturation 13 5.34e-01 9.96e-02 8.21e-01
Listeria monocytogenes entry into host cells 20 4.42e-01 -9.94e-02 7.80e-01
VEGFR2 mediated cell proliferation 19 4.54e-01 -9.93e-02 7.88e-01
Receptor Mediated Mitophagy 11 5.69e-01 -9.92e-02 8.44e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 3.74e-01 9.88e-02 7.45e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 31 3.42e-01 -9.87e-02 7.12e-01
PKA-mediated phosphorylation of key metabolic factors 5 7.03e-01 -9.84e-02 8.91e-01
Gastrin-CREB signalling pathway via PKC and MAPK 18 4.70e-01 -9.84e-02 7.95e-01
Eukaryotic Translation Elongation 93 1.02e-01 9.82e-02 4.80e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 32 3.36e-01 9.82e-02 7.12e-01
Sphingolipid metabolism 107 8.03e-02 -9.79e-02 4.41e-01
A tetrasaccharide linker sequence is required for GAG synthesis 26 3.88e-01 -9.78e-02 7.51e-01
Downstream signaling of activated FGFR3 25 3.98e-01 -9.77e-02 7.56e-01
Selenocysteine synthesis 92 1.06e-01 9.75e-02 4.89e-01
Crosslinking of collagen fibrils 18 4.74e-01 -9.75e-02 7.98e-01
Lagging Strand Synthesis 20 4.51e-01 9.73e-02 7.87e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 5.60e-01 -9.72e-02 8.36e-01
Formation of a pool of free 40S subunits 100 9.31e-02 9.72e-02 4.67e-01
IRS-mediated signalling 48 2.45e-01 -9.70e-02 6.42e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 4.54e-01 9.66e-02 7.88e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 3.16e-01 9.65e-02 7.03e-01
Prostanoid ligand receptors 9 6.16e-01 -9.64e-02 8.63e-01
PI Metabolism 83 1.29e-01 -9.64e-02 5.13e-01
Signaling by Rho GTPases 659 2.43e-05 -9.63e-02 4.88e-03
Interleukin-7 signaling 22 4.34e-01 -9.63e-02 7.77e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 51 2.35e-01 9.60e-02 6.35e-01
Protein methylation 15 5.20e-01 9.60e-02 8.18e-01
Elevation of cytosolic Ca2+ levels 16 5.06e-01 9.59e-02 8.13e-01
Telomere C-strand (Lagging Strand) Synthesis 34 3.33e-01 9.59e-02 7.12e-01
RAS processing 24 4.16e-01 9.58e-02 7.68e-01
FGFRL1 modulation of FGFR1 signaling 13 5.51e-01 9.54e-02 8.30e-01
Formation of the nephric duct 18 4.84e-01 -9.54e-02 8.03e-01
TGF-beta receptor signaling activates SMADs 47 2.58e-01 -9.53e-02 6.51e-01
Formation of the ternary complex, and subsequently, the 43S complex 50 2.44e-01 9.52e-02 6.42e-01
ARMS-mediated activation 7 6.63e-01 -9.52e-02 8.80e-01
Collagen chain trimerization 44 2.76e-01 -9.49e-02 6.72e-01
Metallothioneins bind metals 11 5.86e-01 -9.48e-02 8.50e-01
Mismatch Repair 15 5.25e-01 9.48e-02 8.19e-01
Signaling by CSF1 (M-CSF) in myeloid cells 31 3.61e-01 9.48e-02 7.30e-01
RHO GTPases Activate WASPs and WAVEs 36 3.26e-01 -9.46e-02 7.07e-01
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 8 6.43e-01 9.46e-02 8.75e-01
Uptake and actions of bacterial toxins 28 3.88e-01 -9.43e-02 7.51e-01
Association of TriC/CCT with target proteins during biosynthesis 39 3.08e-01 -9.43e-02 6.96e-01
Negative regulation of MAPK pathway 43 2.85e-01 -9.42e-02 6.77e-01
Retinoid metabolism and transport 44 2.80e-01 -9.41e-02 6.74e-01
Signaling by FGFR2 73 1.65e-01 -9.41e-02 5.78e-01
Signaling by PDGFR in disease 20 4.67e-01 -9.39e-02 7.95e-01
Signaling by FGFR4 41 2.99e-01 -9.37e-02 6.86e-01
Replacement of protamines by nucleosomes in the male pronucleus 22 4.47e-01 -9.37e-02 7.85e-01
Caspase activation via Dependence Receptors in the absence of ligand 10 6.08e-01 9.37e-02 8.63e-01
Termination of translesion DNA synthesis 32 3.60e-01 9.36e-02 7.29e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 675 3.43e-05 -9.34e-02 5.31e-03
Signaling by the B Cell Receptor (BCR) 110 9.05e-02 9.34e-02 4.60e-01
Erythrocytes take up oxygen and release carbon dioxide 8 6.49e-01 -9.31e-02 8.75e-01
Synthesis of IP3 and IP4 in the cytosol 26 4.12e-01 -9.30e-02 7.67e-01
Defective ST3GAL3 causes MCT12 and EIEE15 8 6.49e-01 -9.30e-02 8.75e-01
PI3K Cascade 44 2.89e-01 -9.24e-02 6.79e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 4.43e-01 -9.24e-02 7.81e-01
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 5 7.21e-01 9.22e-02 8.99e-01
TCR signaling 116 8.65e-02 9.21e-02 4.51e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 4.76e-01 9.21e-02 7.99e-01
Ubiquinol biosynthesis 8 6.52e-01 -9.20e-02 8.75e-01
TICAM1-dependent activation of IRF3/IRF7 12 5.81e-01 -9.20e-02 8.49e-01
IRS-related events triggered by IGF1R 52 2.52e-01 -9.19e-02 6.48e-01
Fc epsilon receptor (FCERI) signaling 131 6.95e-02 9.18e-02 4.11e-01
2-LTR circle formation 7 6.74e-01 9.17e-02 8.86e-01
Diseases associated with glycosylation precursor biosynthesis 15 5.39e-01 -9.16e-02 8.24e-01
Reduction of cytosolic Ca++ levels 12 5.83e-01 -9.16e-02 8.49e-01
Diseases of hemostasis 19 4.89e-01 -9.16e-02 8.04e-01
Acyl chain remodeling of DAG and TAG 7 6.75e-01 -9.15e-02 8.86e-01
RHOG GTPase cycle 74 1.74e-01 -9.13e-02 5.92e-01
IRAK4 deficiency (TLR2/4) 18 5.03e-01 9.13e-02 8.13e-01
Mitochondrial Fatty Acid Beta-Oxidation 37 3.37e-01 -9.12e-02 7.12e-01
Potassium Channels 103 1.10e-01 9.12e-02 4.93e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 4.30e-01 9.12e-02 7.77e-01
Free fatty acid receptors 5 7.24e-01 9.12e-02 8.99e-01
Acetylcholine Neurotransmitter Release Cycle 17 5.16e-01 9.11e-02 8.15e-01
SUMOylation of transcription cofactors 44 2.97e-01 -9.09e-02 6.84e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 16 5.29e-01 -9.08e-02 8.21e-01
Collagen degradation 63 2.13e-01 -9.08e-02 6.18e-01
Diseases associated with surfactant metabolism 9 6.37e-01 -9.08e-02 8.73e-01
Metabolism of lipids 754 2.32e-05 -9.05e-02 4.88e-03
Post-translational modification: synthesis of GPI-anchored proteins 93 1.32e-01 9.03e-02 5.15e-01
Cargo recognition for clathrin-mediated endocytosis 104 1.12e-01 -9.02e-02 4.95e-01
Glutathione conjugation 36 3.49e-01 -9.02e-02 7.17e-01
RSV-host interactions 92 1.36e-01 9.00e-02 5.25e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 3.78e-01 9.00e-02 7.48e-01
Defective GALNT12 causes CRCS1 18 5.09e-01 8.99e-02 8.13e-01
RHOD GTPase cycle 52 2.63e-01 -8.97e-02 6.59e-01
cGMP effects 16 5.36e-01 8.94e-02 8.22e-01
G-protein beta:gamma signalling 32 3.83e-01 -8.92e-02 7.51e-01
Cargo trafficking to the periciliary membrane 51 2.71e-01 8.91e-02 6.68e-01
Mitochondrial calcium ion transport 21 4.80e-01 -8.91e-02 8.02e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 106 1.14e-01 -8.89e-02 4.97e-01
Extracellular matrix organization 299 8.20e-03 -8.88e-02 1.67e-01
Myoclonic epilepsy of Lafora 9 6.44e-01 8.88e-02 8.75e-01
Transport and synthesis of PAPS 6 7.06e-01 -8.88e-02 8.92e-01
Activated point mutants of FGFR2 17 5.26e-01 8.88e-02 8.19e-01
Influenza Viral RNA Transcription and Replication 136 7.46e-02 8.85e-02 4.28e-01
Glycolysis 74 1.89e-01 -8.84e-02 6.01e-01
G beta:gamma signalling through BTK 18 5.16e-01 -8.84e-02 8.15e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 95 1.37e-01 8.83e-02 5.25e-01
N-Glycan antennae elongation 15 5.54e-01 8.82e-02 8.32e-01
MyD88 deficiency (TLR2/4) 17 5.30e-01 8.79e-02 8.21e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 31 3.98e-01 8.76e-02 7.57e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.33e-01 -8.74e-02 8.21e-01
Diseases of programmed cell death 68 2.13e-01 -8.72e-02 6.18e-01
Cell Cycle Checkpoints 268 1.40e-02 8.72e-02 2.18e-01
Downstream signaling of activated FGFR4 27 4.33e-01 -8.71e-02 7.77e-01
PI3K/AKT Signaling in Cancer 105 1.24e-01 -8.70e-02 5.07e-01
Positive epigenetic regulation of rRNA expression 69 2.12e-01 -8.69e-02 6.18e-01
Anti-inflammatory response favouring Leishmania parasite infection 77 1.88e-01 -8.68e-02 6.01e-01
Leishmania parasite growth and survival 77 1.88e-01 -8.68e-02 6.01e-01
Maturation of nucleoprotein 9683610 11 6.18e-01 -8.68e-02 8.63e-01
TRP channels 28 4.27e-01 8.66e-02 7.75e-01
Signaling by Non-Receptor Tyrosine Kinases 54 2.72e-01 -8.65e-02 6.68e-01
Signaling by PTK6 54 2.72e-01 -8.65e-02 6.68e-01
HSF1-dependent transactivation 36 3.69e-01 -8.64e-02 7.40e-01
Cristae formation 28 4.29e-01 8.64e-02 7.75e-01
Degradation of the extracellular matrix 139 7.90e-02 -8.63e-02 4.38e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 19 5.16e-01 -8.61e-02 8.15e-01
Cellular response to starvation 153 6.62e-02 8.60e-02 4.05e-01
Aspartate and asparagine metabolism 11 6.22e-01 8.58e-02 8.63e-01
RNA Polymerase III Transcription Termination 23 4.77e-01 -8.57e-02 7.99e-01
Nucleotide salvage 23 4.77e-01 -8.57e-02 7.99e-01
Peroxisomal protein import 63 2.40e-01 -8.56e-02 6.39e-01
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 9 6.57e-01 -8.56e-02 8.76e-01
FRS-mediated FGFR3 signaling 20 5.08e-01 -8.55e-02 8.13e-01
Nicotinamide salvaging 19 5.19e-01 -8.54e-02 8.18e-01
HDR through Homologous Recombination (HRR) 66 2.31e-01 8.52e-02 6.31e-01
VLDLR internalisation and degradation 16 5.55e-01 -8.52e-02 8.32e-01
Epigenetic regulation of gene expression 149 7.29e-02 -8.51e-02 4.25e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.62e-01 8.49e-02 7.94e-01
Glyoxylate metabolism and glycine degradation 31 4.14e-01 -8.48e-02 7.67e-01
Regulation of actin dynamics for phagocytic cup formation 61 2.52e-01 -8.47e-02 6.48e-01
RUNX3 regulates BCL2L11 (BIM) transcription 5 7.43e-01 -8.47e-02 9.10e-01
Triglyceride catabolism 23 4.83e-01 -8.44e-02 8.03e-01
The activation of arylsulfatases 13 5.98e-01 -8.44e-02 8.57e-01
Ribavirin ADME 11 6.28e-01 -8.43e-02 8.67e-01
Meiotic synapsis 56 2.76e-01 -8.42e-02 6.72e-01
Cap-dependent Translation Initiation 118 1.14e-01 8.41e-02 4.97e-01
Eukaryotic Translation Initiation 118 1.14e-01 8.41e-02 4.97e-01
Glutamate and glutamine metabolism 13 5.99e-01 8.41e-02 8.57e-01
Effects of PIP2 hydrolysis 27 4.49e-01 -8.41e-02 7.86e-01
Transcriptional Regulation by E2F6 34 3.97e-01 8.40e-02 7.55e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 6.46e-01 8.39e-02 8.75e-01
RHOJ GTPase cycle 54 2.87e-01 -8.37e-02 6.77e-01
AMPK inhibits chREBP transcriptional activation activity 8 6.82e-01 8.35e-02 8.86e-01
Protein repair 6 7.23e-01 8.35e-02 8.99e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 89 1.75e-01 8.32e-02 5.92e-01
Cobalamin (Cbl) metabolism 7 7.03e-01 8.32e-02 8.91e-01
Costimulation by the CD28 family 66 2.43e-01 -8.32e-02 6.40e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 22 5.01e-01 -8.28e-02 8.13e-01
Neurodegenerative Diseases 22 5.01e-01 -8.28e-02 8.13e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 19 5.33e-01 -8.27e-02 8.21e-01
RNA Polymerase I Promoter Clearance 72 2.26e-01 -8.25e-02 6.26e-01
RNA Polymerase I Transcription 72 2.26e-01 -8.25e-02 6.26e-01
Keratan sulfate biosynthesis 28 4.51e-01 -8.23e-02 7.87e-01
Triglyceride metabolism 37 3.87e-01 -8.21e-02 7.51e-01
Transport of bile salts and organic acids, metal ions and amine compounds 84 1.94e-01 -8.20e-02 6.07e-01
MET interacts with TNS proteins 5 7.51e-01 -8.20e-02 9.14e-01
Signaling by FGFR1 52 3.11e-01 -8.12e-02 6.98e-01
Late endosomal microautophagy 34 4.13e-01 -8.12e-02 7.67e-01
Lysosome Vesicle Biogenesis 34 4.14e-01 -8.10e-02 7.67e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 15 5.88e-01 -8.09e-02 8.51e-01
Propionyl-CoA catabolism 5 7.54e-01 8.08e-02 9.17e-01
MyD88 cascade initiated on plasma membrane 96 1.71e-01 -8.08e-02 5.88e-01
Toll Like Receptor 10 (TLR10) Cascade 96 1.71e-01 -8.08e-02 5.88e-01
Toll Like Receptor 5 (TLR5) Cascade 96 1.71e-01 -8.08e-02 5.88e-01
HCMV Late Events 82 2.07e-01 -8.07e-02 6.09e-01
Killing mechanisms 12 6.29e-01 8.06e-02 8.67e-01
WNT5:FZD7-mediated leishmania damping 12 6.29e-01 8.06e-02 8.67e-01
Influenza Infection 155 8.44e-02 8.03e-02 4.50e-01
Dual Incision in GG-NER 40 3.80e-01 8.03e-02 7.48e-01
Respiratory electron transport 93 1.81e-01 8.02e-02 5.96e-01
Interferon gamma signaling 94 1.79e-01 -8.01e-02 5.94e-01
Gap junction trafficking and regulation 49 3.32e-01 -8.01e-02 7.12e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.45e-01 8.00e-02 5.42e-01
STAT5 activation downstream of FLT3 ITD mutants 10 6.61e-01 -8.00e-02 8.80e-01
Metabolism of fat-soluble vitamins 48 3.38e-01 -7.99e-02 7.12e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 5.80e-01 7.98e-02 8.49e-01
PERK regulates gene expression 32 4.36e-01 7.95e-02 7.77e-01
Membrane Trafficking 626 6.81e-04 -7.95e-02 5.27e-02
MECP2 regulates transcription of neuronal ligands 8 6.98e-01 7.93e-02 8.90e-01
Amino acid transport across the plasma membrane 33 4.31e-01 -7.92e-02 7.77e-01
SARS-CoV-2 modulates host translation machinery 49 3.38e-01 7.92e-02 7.12e-01
Protein folding 97 1.78e-01 -7.92e-02 5.92e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 1.52e-01 7.91e-02 5.54e-01
Adherens junctions interactions 59 2.94e-01 -7.90e-02 6.83e-01
Formation of axial mesoderm 14 6.09e-01 -7.88e-02 8.63e-01
Estrogen-dependent gene expression 116 1.43e-01 -7.88e-02 5.37e-01
ROS and RNS production in phagocytes 35 4.21e-01 7.86e-02 7.69e-01
SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7 7.19e-01 7.85e-02 8.99e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 93 1.91e-01 7.85e-02 6.05e-01
Defective CHST14 causes EDS, musculocontractural type 8 7.01e-01 7.84e-02 8.91e-01
Triglyceride biosynthesis 14 6.12e-01 -7.82e-02 8.63e-01
DNA Damage Bypass 47 3.54e-01 7.82e-02 7.19e-01
IGF1R signaling cascade 53 3.25e-01 -7.82e-02 7.07e-01
Uptake of dietary cobalamins into enterocytes 9 6.85e-01 7.81e-02 8.86e-01
Calcineurin activates NFAT 9 6.85e-01 7.81e-02 8.86e-01
RNA Polymerase III Abortive And Retractive Initiation 41 3.87e-01 -7.80e-02 7.51e-01
RNA Polymerase III Transcription 41 3.87e-01 -7.80e-02 7.51e-01
FGFR2c ligand binding and activation 13 6.27e-01 7.78e-02 8.67e-01
Gastrulation 127 1.31e-01 7.76e-02 5.13e-01
Defective GALNT3 causes HFTC 18 5.69e-01 7.75e-02 8.44e-01
Vitamin B5 (pantothenate) metabolism 20 5.49e-01 7.74e-02 8.30e-01
Activation of GABAB receptors 43 3.80e-01 -7.73e-02 7.48e-01
GABA B receptor activation 43 3.80e-01 -7.73e-02 7.48e-01
Regulation of NPAS4 gene transcription 5 7.65e-01 7.72e-02 9.20e-01
G beta:gamma signalling through CDC42 20 5.50e-01 -7.71e-02 8.30e-01
Synthesis of 15-eicosatetraenoic acid derivatives 6 7.44e-01 -7.71e-02 9.10e-01
Fibronectin matrix formation 6 7.44e-01 7.70e-02 9.10e-01
Chaperonin-mediated protein folding 91 2.05e-01 -7.69e-02 6.08e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 24 5.15e-01 7.68e-02 8.15e-01
Synthesis of GDP-mannose 5 7.66e-01 -7.68e-02 9.20e-01
Defective Intrinsic Pathway for Apoptosis 25 5.07e-01 -7.67e-02 8.13e-01
RHOBTB3 ATPase cycle 10 6.75e-01 7.67e-02 8.86e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 5.16e-01 7.66e-02 8.15e-01
HATs acetylate histones 104 1.78e-01 -7.64e-02 5.92e-01
Clathrin-mediated endocytosis 144 1.14e-01 -7.63e-02 4.97e-01
Defective CSF2RA causes SMDP4 7 7.27e-01 -7.63e-02 9.00e-01
Defective CSF2RB causes SMDP5 7 7.27e-01 -7.63e-02 9.00e-01
Serotonin Neurotransmitter Release Cycle 18 5.76e-01 7.62e-02 8.48e-01
Mitotic Metaphase and Anaphase 233 4.50e-02 7.62e-02 3.67e-01
tRNA processing 109 1.70e-01 7.61e-02 5.87e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 4.37e-01 7.59e-02 7.77e-01
Atorvastatin ADME 9 6.95e-01 7.54e-02 8.90e-01
Glycogen synthesis 14 6.26e-01 7.52e-02 8.66e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 6.03e-01 -7.51e-02 8.59e-01
Chromatin modifications during the maternal to zygotic transition (MZT) 33 4.56e-01 -7.50e-02 7.90e-01
RHOH GTPase cycle 36 4.37e-01 -7.49e-02 7.77e-01
Presynaptic nicotinic acetylcholine receptors 12 6.54e-01 7.48e-02 8.76e-01
GPCR ligand binding 461 5.94e-03 7.47e-02 1.46e-01
Norepinephrine Neurotransmitter Release Cycle 18 5.84e-01 7.46e-02 8.49e-01
Suppression of apoptosis 7 7.33e-01 -7.44e-02 9.04e-01
Transcriptional regulation of pluripotent stem cells 29 4.89e-01 7.43e-02 8.04e-01
Mitotic Anaphase 232 5.13e-02 7.42e-02 3.79e-01
Vesicle-mediated transport 664 1.09e-03 -7.42e-02 7.08e-02
Recognition of DNA damage by PCNA-containing replication complex 30 4.83e-01 7.40e-02 8.03e-01
Vasopressin-like receptors 6 7.54e-01 -7.40e-02 9.16e-01
Relaxin receptors 8 7.18e-01 7.39e-02 8.99e-01
NF-kB is activated and signals survival 13 6.45e-01 -7.37e-02 8.75e-01
FRS-mediated FGFR4 signaling 22 5.50e-01 -7.36e-02 8.30e-01
Peptide ligand-binding receptors 196 7.58e-02 7.35e-02 4.31e-01
MyD88-independent TLR4 cascade 108 1.88e-01 -7.34e-02 6.01e-01
TRIF(TICAM1)-mediated TLR4 signaling 108 1.88e-01 -7.34e-02 6.01e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 56 3.43e-01 -7.32e-02 7.12e-01
Class B/2 (Secretin family receptors) 93 2.23e-01 7.32e-02 6.26e-01
Defective pyroptosis 36 4.48e-01 -7.31e-02 7.86e-01
Maturation of nucleoprotein 9694631 15 6.24e-01 -7.31e-02 8.64e-01
Processive synthesis on the C-strand of the telomere 19 5.84e-01 7.25e-02 8.49e-01
Mitochondrial RNA degradation 10 6.91e-01 7.25e-02 8.89e-01
RA biosynthesis pathway 22 5.56e-01 7.25e-02 8.33e-01
Transport of connexons to the plasma membrane 19 5.84e-01 7.25e-02 8.49e-01
Inhibition of DNA recombination at telomere 44 4.06e-01 -7.23e-02 7.67e-01
Defective B4GALT7 causes EDS, progeroid type 20 5.76e-01 -7.23e-02 8.48e-01
Deactivation of the beta-catenin transactivating complex 41 4.23e-01 -7.22e-02 7.69e-01
Extension of Telomeres 51 3.73e-01 7.21e-02 7.44e-01
Biotin transport and metabolism 11 6.79e-01 -7.20e-02 8.86e-01
Regulation of gene expression in beta cells 21 5.68e-01 7.19e-02 8.44e-01
Regulation of KIT signaling 16 6.19e-01 -7.19e-02 8.63e-01
Programmed Cell Death 209 7.41e-02 -7.17e-02 4.27e-01
Defective CHST6 causes MCDC1 8 7.26e-01 -7.16e-02 9.00e-01
Metabolism of amine-derived hormones 17 6.10e-01 7.15e-02 8.63e-01
tRNA processing in the nucleus 59 3.43e-01 7.14e-02 7.12e-01
RAS signaling downstream of NF1 loss-of-function variants 7 7.44e-01 7.13e-02 9.10e-01
Formation of apoptosome 11 6.83e-01 -7.11e-02 8.86e-01
Regulation of the apoptosome activity 11 6.83e-01 -7.11e-02 8.86e-01
Ovarian tumor domain proteases 39 4.43e-01 -7.11e-02 7.81e-01
VEGF binds to VEGFR leading to receptor dimerization 8 7.28e-01 -7.10e-02 9.00e-01
VEGF ligand-receptor interactions 8 7.28e-01 -7.10e-02 9.00e-01
Rap1 signalling 16 6.24e-01 -7.08e-02 8.64e-01
Retrograde transport at the Trans-Golgi-Network 49 3.91e-01 -7.08e-02 7.54e-01
Depolymerization of the Nuclear Lamina 15 6.36e-01 7.06e-02 8.72e-01
Global Genome Nucleotide Excision Repair (GG-NER) 83 2.67e-01 7.05e-02 6.66e-01
Signaling by Insulin receptor 81 2.73e-01 -7.04e-02 6.69e-01
Signaling by FGFR in disease 63 3.34e-01 -7.03e-02 7.12e-01
Resolution of D-Loop Structures 33 4.84e-01 7.03e-02 8.03e-01
Signaling by NOTCH1 74 2.96e-01 -7.03e-02 6.84e-01
Metabolism of water-soluble vitamins and cofactors 126 1.73e-01 -7.03e-02 5.90e-01
Defective binding of VWF variant to GPIb:IX:V 7 7.48e-01 -7.01e-02 9.12e-01
Enhanced binding of GP1BA variant to VWF multimer:collagen 7 7.48e-01 -7.01e-02 9.12e-01
NPAS4 regulates expression of target genes 21 5.81e-01 6.97e-02 8.49e-01
ER-Phagosome pathway 91 2.51e-01 6.96e-02 6.48e-01
Phosphorylation of CD3 and TCR zeta chains 20 5.90e-01 6.96e-02 8.53e-01
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 6 7.69e-01 -6.93e-02 9.21e-01
Downstream signaling of activated FGFR1 31 5.06e-01 -6.90e-02 8.13e-01
ER to Golgi Anterograde Transport 153 1.41e-01 -6.89e-02 5.35e-01
SLC transporter disorders 99 2.37e-01 -6.88e-02 6.36e-01
Diseases of glycosylation 145 1.54e-01 -6.86e-02 5.54e-01
RAC3 GTPase cycle 94 2.50e-01 -6.86e-02 6.47e-01
Reactions specific to the complex N-glycan synthesis pathway 10 7.07e-01 -6.86e-02 8.92e-01
Loss of Nlp from mitotic centrosomes 69 3.25e-01 -6.85e-02 7.07e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 3.25e-01 -6.85e-02 7.07e-01
Interactions of Vpr with host cellular proteins 36 4.78e-01 6.83e-02 8.00e-01
SLC-mediated transmembrane transport 247 6.50e-02 -6.81e-02 4.02e-01
NOTCH1 Intracellular Domain Regulates Transcription 48 4.15e-01 -6.81e-02 7.67e-01
Golgi-to-ER retrograde transport 133 1.76e-01 -6.79e-02 5.92e-01
Negative regulation of FGFR3 signaling 29 5.27e-01 -6.79e-02 8.19e-01
PI-3K cascade:FGFR3 18 6.19e-01 -6.77e-02 8.63e-01
Synthesis of bile acids and bile salts 34 4.95e-01 6.76e-02 8.10e-01
Metabolism of steroids 155 1.47e-01 -6.74e-02 5.46e-01
Glutamate Neurotransmitter Release Cycle 24 5.68e-01 6.74e-02 8.44e-01
Metabolism of vitamins and cofactors 191 1.08e-01 -6.74e-02 4.92e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.52e-01 6.73e-02 8.75e-01
Synthesis of PIPs at the ER membrane 5 7.95e-01 -6.73e-02 9.35e-01
Protein hydroxylation 18 6.21e-01 -6.72e-02 8.63e-01
Amyloid fiber formation 74 3.18e-01 -6.71e-02 7.03e-01
Formation of xylulose-5-phosphate 5 7.95e-01 -6.71e-02 9.36e-01
ER Quality Control Compartment (ERQC) 21 5.95e-01 6.70e-02 8.57e-01
C-type lectin receptors (CLRs) 142 1.69e-01 6.69e-02 5.85e-01
Glycosphingolipid catabolism 39 4.70e-01 -6.68e-02 7.95e-01
Cleavage of the damaged purine 33 5.07e-01 -6.67e-02 8.13e-01
Depurination 33 5.07e-01 -6.67e-02 8.13e-01
Recognition and association of DNA glycosylase with site containing an affected purine 33 5.07e-01 -6.67e-02 8.13e-01
FGFR2 mutant receptor activation 33 5.07e-01 6.67e-02 8.13e-01
Cytosolic sensors of pathogen-associated DNA 64 3.56e-01 -6.67e-02 7.23e-01
Regulation of insulin secretion 78 3.10e-01 -6.65e-02 6.97e-01
Arachidonic acid metabolism 59 3.78e-01 6.63e-02 7.48e-01
FGFR2 ligand binding and activation 20 6.08e-01 6.63e-02 8.63e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 6.68e-01 6.63e-02 8.82e-01
Neurotransmitter receptors and postsynaptic signal transmission 203 1.04e-01 6.63e-02 4.85e-01
Dermatan sulfate biosynthesis 11 7.04e-01 6.62e-02 8.91e-01
DAP12 signaling 28 5.45e-01 -6.61e-02 8.30e-01
Complement cascade 56 3.92e-01 -6.61e-02 7.54e-01
Vpr-mediated nuclear import of PICs 34 5.06e-01 6.60e-02 8.13e-01
Hedgehog ‘on’ state 86 2.90e-01 6.59e-02 6.81e-01
ALK mutants bind TKIs 12 6.92e-01 6.59e-02 8.89e-01
HCMV Infection 127 2.00e-01 -6.58e-02 6.08e-01
Cytochrome c-mediated apoptotic response 13 6.82e-01 -6.56e-02 8.86e-01
SARS-CoV-2 modulates autophagy 11 7.07e-01 6.55e-02 8.92e-01
Post-translational protein phosphorylation 105 2.46e-01 -6.55e-02 6.42e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 5.96e-01 6.53e-02 8.57e-01
Respiratory Syncytial Virus Infection Pathway 114 2.30e-01 6.51e-02 6.30e-01
Signaling by Receptor Tyrosine Kinases 527 1.05e-02 -6.51e-02 1.93e-01
Metabolism of folate and pterines 17 6.43e-01 -6.48e-02 8.75e-01
Defective B3GAT3 causes JDSSDHD 20 6.16e-01 -6.48e-02 8.63e-01
Diseases associated with O-glycosylation of proteins 70 3.48e-01 -6.48e-02 7.17e-01
Formation of Fibrin Clot (Clotting Cascade) 39 4.86e-01 -6.44e-02 8.03e-01
Alpha-oxidation of phytanate 6 7.85e-01 -6.44e-02 9.32e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 6.56e-01 6.44e-02 8.76e-01
Diseases associated with the TLR signaling cascade 31 5.35e-01 -6.44e-02 8.21e-01
Diseases of Immune System 31 5.35e-01 -6.44e-02 8.21e-01
Surfactant metabolism 27 5.63e-01 6.43e-02 8.40e-01
Neuronal System 410 2.55e-02 6.43e-02 2.83e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 54 4.15e-01 -6.41e-02 7.67e-01
Other interleukin signaling 24 5.88e-01 -6.39e-02 8.51e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 55 4.13e-01 -6.38e-02 7.67e-01
Defects of platelet adhesion to exposed collagen 8 7.55e-01 -6.36e-02 9.17e-01
Gap junction trafficking 47 4.51e-01 -6.35e-02 7.87e-01
Transmission across Chemical Synapses 268 7.36e-02 6.35e-02 4.26e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 6.06e-01 -6.35e-02 8.62e-01
Telomere Extension By Telomerase 23 5.98e-01 6.35e-02 8.57e-01
MAP2K and MAPK activation 40 4.88e-01 -6.34e-02 8.04e-01
WNT ligand biogenesis and trafficking 26 5.76e-01 -6.34e-02 8.48e-01
Ion transport by P-type ATPases 55 4.17e-01 -6.33e-02 7.68e-01
Miscellaneous transport and binding events 26 5.77e-01 6.32e-02 8.48e-01
Protein ubiquitination 76 3.41e-01 6.31e-02 7.12e-01
RNA Polymerase I Transcription Initiation 46 4.59e-01 -6.31e-02 7.92e-01
Transport of nucleotide sugars 9 7.43e-01 -6.31e-02 9.10e-01
PD-1 signaling 21 6.17e-01 6.30e-02 8.63e-01
Lectin pathway of complement activation 8 7.58e-01 -6.30e-02 9.18e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 5.14e-01 6.29e-02 8.15e-01
Toll Like Receptor 3 (TLR3) Cascade 104 2.68e-01 -6.29e-02 6.66e-01
DNA Double Strand Break Response 57 4.13e-01 -6.27e-02 7.67e-01
Resolution of Abasic Sites (AP sites) 38 5.03e-01 6.27e-02 8.13e-01
FGFR3 ligand binding and activation 13 6.95e-01 -6.27e-02 8.90e-01
FGFR3c ligand binding and activation 13 6.95e-01 -6.27e-02 8.90e-01
CLEC7A (Dectin-1) induces NFAT activation 11 7.19e-01 6.26e-02 8.99e-01
Processive synthesis on the lagging strand 15 6.75e-01 6.26e-02 8.86e-01
Synthesis of PIPs at the plasma membrane 53 4.31e-01 -6.25e-02 7.77e-01
GPVI-mediated activation cascade 34 5.32e-01 -6.19e-02 8.21e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.51e-01 6.18e-02 8.30e-01
Cytosolic sulfonation of small molecules 22 6.18e-01 -6.15e-02 8.63e-01
Negative regulation of FLT3 15 6.81e-01 6.14e-02 8.86e-01
Mitochondrial translation termination 87 3.23e-01 6.13e-02 7.07e-01
Biological oxidations 216 1.22e-01 6.11e-02 5.02e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 30 5.65e-01 6.07e-02 8.41e-01
Negative regulation of FGFR4 signaling 31 5.59e-01 -6.06e-02 8.35e-01
COPI-dependent Golgi-to-ER retrograde traffic 99 2.98e-01 -6.05e-02 6.84e-01
Signaling by NOTCH 211 1.30e-01 -6.04e-02 5.13e-01
NCAM1 interactions 42 4.99e-01 -6.03e-02 8.12e-01
rRNA processing in the nucleus and cytosol 190 1.52e-01 6.02e-02 5.54e-01
p75NTR signals via NF-kB 16 6.77e-01 -6.02e-02 8.86e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 6.87e-01 6.00e-02 8.87e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 30 5.70e-01 -6.00e-02 8.44e-01
Serine biosynthesis 9 7.57e-01 5.96e-02 9.18e-01
Cleavage of the damaged pyrimidine 38 5.26e-01 -5.94e-02 8.19e-01
Depyrimidination 38 5.26e-01 -5.94e-02 8.19e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 38 5.26e-01 -5.94e-02 8.19e-01
Formation of the cornified envelope 125 2.54e-01 5.91e-02 6.48e-01
Platelet activation, signaling and aggregation 259 1.02e-01 -5.89e-02 4.82e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.03e-01 5.88e-02 8.91e-01
Ca2+ pathway 62 4.23e-01 -5.88e-02 7.69e-01
rRNA processing 200 1.53e-01 5.86e-02 5.54e-01
CREB3 factors activate genes 9 7.61e-01 -5.85e-02 9.20e-01
Signaling by WNT 293 8.60e-02 -5.83e-02 4.50e-01
Regulation of Complement cascade 45 4.99e-01 -5.82e-02 8.12e-01
EPHA-mediated growth cone collapse 29 5.88e-01 -5.81e-02 8.51e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 121 2.71e-01 5.80e-02 6.68e-01
Antigen processing-Cross presentation 105 3.05e-01 5.79e-02 6.91e-01
Calnexin/calreticulin cycle 26 6.09e-01 5.79e-02 8.63e-01
Bacterial Infection Pathways 69 4.06e-01 -5.78e-02 7.67e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 45 5.03e-01 -5.78e-02 8.13e-01
TP53 Regulates Transcription of DNA Repair Genes 61 4.35e-01 5.77e-02 7.77e-01
RHOBTB GTPase Cycle 35 5.55e-01 5.76e-02 8.32e-01
HIV elongation arrest and recovery 33 5.72e-01 -5.68e-02 8.46e-01
Pausing and recovery of HIV elongation 33 5.72e-01 -5.68e-02 8.46e-01
Trafficking of GluR2-containing AMPA receptors 17 6.85e-01 -5.68e-02 8.86e-01
Early SARS-CoV-2 Infection Events 37 5.50e-01 -5.68e-02 8.30e-01
Recycling of bile acids and salts 18 6.77e-01 -5.67e-02 8.86e-01
Anchoring of the basal body to the plasma membrane 96 3.37e-01 -5.67e-02 7.12e-01
Response of Mtb to phagocytosis 23 6.39e-01 5.66e-02 8.74e-01
Tie2 Signaling 18 6.78e-01 5.66e-02 8.86e-01
Synthesis of PA 38 5.47e-01 -5.65e-02 8.30e-01
PI-3K cascade:FGFR4 20 6.62e-01 -5.65e-02 8.80e-01
SHC-mediated cascade:FGFR2 23 6.40e-01 5.64e-02 8.74e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 115 2.97e-01 5.62e-02 6.84e-01
Nonsense-Mediated Decay (NMD) 115 2.97e-01 5.62e-02 6.84e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 41 5.34e-01 5.61e-02 8.21e-01
Role of ABL in ROBO-SLIT signaling 8 7.84e-01 -5.60e-02 9.31e-01
O-glycosylation of TSR domain-containing proteins 39 5.46e-01 -5.59e-02 8.30e-01
TNFR2 non-canonical NF-kB pathway 99 3.40e-01 5.55e-02 7.12e-01
Metabolism 2091 2.79e-05 -5.55e-02 5.09e-03
Erythropoietin activates RAS 14 7.20e-01 -5.54e-02 8.99e-01
Formation of the Editosome 8 7.87e-01 5.52e-02 9.32e-01
mRNA Editing: C to U Conversion 8 7.87e-01 5.52e-02 9.32e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 28 6.14e-01 5.51e-02 8.63e-01
Regulation of beta-cell development 42 5.37e-01 5.51e-02 8.23e-01
Intracellular signaling by second messengers 327 8.74e-02 -5.50e-02 4.51e-01
SIRT1 negatively regulates rRNA expression 31 5.97e-01 -5.48e-02 8.57e-01
Signaling by ERBB4 58 4.70e-01 -5.48e-02 7.95e-01
Mitophagy 28 6.17e-01 5.46e-02 8.63e-01
O-linked glycosylation of mucins 63 4.54e-01 5.45e-02 7.88e-01
HDMs demethylate histones 21 6.66e-01 -5.45e-02 8.81e-01
Sperm Motility And Taxes 9 7.77e-01 5.44e-02 9.26e-01
Regulation of signaling by CBL 22 6.59e-01 5.44e-02 8.78e-01
ABC transporters in lipid homeostasis 18 6.90e-01 5.43e-02 8.89e-01
Transcription of the HIV genome 69 4.37e-01 5.42e-02 7.77e-01
Transport to the Golgi and subsequent modification 184 2.06e-01 -5.40e-02 6.09e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 15 7.19e-01 5.37e-02 8.99e-01
Mitotic G2-G2/M phases 197 1.95e-01 5.36e-02 6.07e-01
Translation 287 1.18e-01 5.36e-02 5.00e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 6.87e-01 5.35e-02 8.87e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 6.01e-01 5.34e-02 8.58e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 12 7.49e-01 5.33e-02 9.13e-01
Deposition of new CENPA-containing nucleosomes at the centromere 48 5.23e-01 5.33e-02 8.18e-01
Nucleosome assembly 48 5.23e-01 5.33e-02 8.18e-01
Mitochondrial protein import 62 4.70e-01 5.30e-02 7.95e-01
InlB-mediated entry of Listeria monocytogenes into host cell 15 7.23e-01 5.29e-02 8.99e-01
Signaling by Erythropoietin 25 6.48e-01 -5.28e-02 8.75e-01
RHOT2 GTPase cycle 7 8.09e-01 -5.27e-02 9.40e-01
Resolution of Sister Chromatid Cohesion 123 3.12e-01 5.27e-02 7.00e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 16 7.15e-01 -5.27e-02 8.99e-01
Apoptosis 178 2.25e-01 -5.27e-02 6.26e-01
Receptor-type tyrosine-protein phosphatases 20 6.84e-01 5.26e-02 8.86e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 122 3.15e-01 -5.26e-02 7.03e-01
Downregulation of ERBB2 signaling 29 6.24e-01 -5.26e-02 8.64e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 7.63e-01 -5.25e-02 9.20e-01
Regulation of TP53 Activity 159 2.53e-01 -5.25e-02 6.48e-01
Ras activation upon Ca2+ influx through NMDA receptor 20 6.85e-01 5.25e-02 8.86e-01
Diseases of signal transduction by growth factor receptors and second messengers 457 5.51e-02 -5.23e-02 3.87e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 2.26e-01 5.23e-02 6.26e-01
Muscle contraction 202 2.01e-01 -5.22e-02 6.08e-01
Infection with Mycobacterium tuberculosis 26 6.45e-01 5.22e-02 8.75e-01
Apoptosis induced DNA fragmentation 13 7.45e-01 -5.21e-02 9.10e-01
Chromosome Maintenance 114 3.37e-01 5.21e-02 7.12e-01
Hormone ligand-binding receptors 13 7.45e-01 -5.20e-02 9.10e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 112 3.42e-01 -5.19e-02 7.12e-01
Toll Like Receptor TLR6:TLR2 Cascade 112 3.42e-01 -5.19e-02 7.12e-01
Constitutive Signaling by Aberrant PI3K in Cancer 78 4.28e-01 -5.19e-02 7.75e-01
Selenoamino acid metabolism 115 3.37e-01 5.18e-02 7.12e-01
The citric acid (TCA) cycle and respiratory electron transport 166 2.51e-01 5.17e-02 6.47e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 5.06e-01 -5.13e-02 8.13e-01
Signal Transduction 2571 2.18e-05 -5.13e-02 4.88e-03
RHO GTPase Effectors 284 1.37e-01 -5.12e-02 5.25e-01
Oxidative Stress Induced Senescence 89 4.05e-01 -5.11e-02 7.66e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 7.08e-01 5.11e-02 8.92e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 7.24e-01 -5.10e-02 8.99e-01
E3 ubiquitin ligases ubiquitinate target proteins 56 5.10e-01 5.09e-02 8.15e-01
SARS-CoV-1 activates/modulates innate immune responses 40 5.79e-01 5.07e-02 8.48e-01
Interferon Signaling 260 1.60e-01 -5.06e-02 5.65e-01
Cellular response to mitochondrial stress 9 7.93e-01 -5.05e-02 9.35e-01
SUMO E3 ligases SUMOylate target proteins 169 2.58e-01 -5.05e-02 6.51e-01
Host Interactions of HIV factors 130 3.21e-01 5.04e-02 7.06e-01
Transcriptional regulation by RUNX2 120 3.41e-01 5.04e-02 7.12e-01
Class A/1 (Rhodopsin-like receptors) 329 1.18e-01 5.01e-02 5.00e-01
M-decay: degradation of maternal mRNAs by maternally stored factors 45 5.61e-01 5.01e-02 8.37e-01
G beta:gamma signalling through PLC beta 20 6.98e-01 -5.01e-02 8.90e-01
CLEC7A (Dectin-1) signaling 100 3.88e-01 5.00e-02 7.51e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 31 6.31e-01 -4.98e-02 8.69e-01
Trafficking of AMPA receptors 31 6.31e-01 -4.98e-02 8.69e-01
Signaling by ROBO receptors 217 2.07e-01 4.97e-02 6.09e-01
Translation initiation complex formation 57 5.17e-01 4.96e-02 8.15e-01
G2/M Transition 195 2.33e-01 4.95e-02 6.31e-01
mRNA Splicing - Minor Pathway 53 5.33e-01 4.95e-02 8.21e-01
NS1 Mediated Effects on Host Pathways 41 5.86e-01 4.91e-02 8.50e-01
Drug-mediated inhibition of CDK4/CDK6 activity 5 8.49e-01 -4.91e-02 9.65e-01
Cytosolic tRNA aminoacylation 22 6.90e-01 -4.91e-02 8.89e-01
FLT3 signaling in disease 28 6.53e-01 -4.91e-02 8.75e-01
Phospholipase C-mediated cascade; FGFR2 18 7.20e-01 4.88e-02 8.99e-01
ZBP1(DAI) mediated induction of type I IFNs 21 7.00e-01 -4.86e-02 8.90e-01
CD22 mediated BCR regulation 5 8.52e-01 4.82e-02 9.65e-01
Mitotic Prophase 106 3.92e-01 -4.82e-02 7.54e-01
DNA Damage Recognition in GG-NER 38 6.07e-01 4.82e-02 8.63e-01
SHC1 events in ERBB4 signaling 14 7.56e-01 -4.80e-02 9.17e-01
Cardiac conduction 130 3.46e-01 4.79e-02 7.15e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 30 6.51e-01 -4.77e-02 8.75e-01
Fatty acid metabolism 177 2.75e-01 -4.76e-02 6.71e-01
Stimuli-sensing channels 107 3.97e-01 4.74e-02 7.55e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 7.21e-01 -4.73e-02 8.99e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 7.21e-01 -4.73e-02 8.99e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 5.34e-01 4.72e-02 8.21e-01
Azathioprine ADME 23 6.96e-01 -4.71e-02 8.90e-01
Extrinsic Pathway of Fibrin Clot Formation 5 8.56e-01 4.70e-02 9.66e-01
Mitotic Spindle Checkpoint 110 3.95e-01 4.70e-02 7.55e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 106 4.04e-01 -4.69e-02 7.65e-01
Diseases of mitotic cell cycle 38 6.18e-01 4.67e-02 8.63e-01
Platelet homeostasis 85 4.57e-01 -4.67e-02 7.91e-01
Interleukin-27 signaling 11 7.90e-01 4.63e-02 9.34e-01
Ribosomal scanning and start codon recognition 57 5.46e-01 4.62e-02 8.30e-01
Diseases of metabolism 249 2.11e-01 -4.60e-02 6.17e-01
Fertilization 26 6.85e-01 4.60e-02 8.86e-01
Defective CHSY1 causes TPBS 8 8.23e-01 4.57e-02 9.47e-01
Antiviral mechanism by IFN-stimulated genes 148 3.38e-01 -4.56e-02 7.12e-01
Integration of provirus 9 8.14e-01 4.53e-02 9.42e-01
Bile acid and bile salt metabolism 45 6.00e-01 4.52e-02 8.57e-01
Hedgehog ‘off’ state 112 4.10e-01 4.51e-02 7.67e-01
RIPK1-mediated regulated necrosis 31 6.64e-01 -4.50e-02 8.80e-01
Regulation of necroptotic cell death 31 6.64e-01 -4.50e-02 8.80e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 6.75e-01 4.49e-02 8.86e-01
Regulation of BACH1 activity 16 7.58e-01 4.45e-02 9.18e-01
Mitochondrial biogenesis 89 4.68e-01 -4.45e-02 7.95e-01
Mitochondrial translation initiation 87 4.76e-01 4.42e-02 7.99e-01
Metabolism of steroid hormones 36 6.46e-01 -4.42e-02 8.75e-01
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 6 8.51e-01 4.41e-02 9.65e-01
Activation of kainate receptors upon glutamate binding 30 6.76e-01 4.41e-02 8.86e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 6.92e-01 4.41e-02 8.89e-01
FGFR2b ligand binding and activation 10 8.10e-01 -4.40e-02 9.40e-01
Dual incision in TC-NER 64 5.44e-01 4.38e-02 8.30e-01
Drug ADME 104 4.40e-01 4.38e-02 7.80e-01
Interleukin-10 signaling 44 6.18e-01 4.34e-02 8.63e-01
AURKA Activation by TPX2 72 5.24e-01 -4.34e-02 8.18e-01
Sensory perception of taste 47 6.11e-01 4.29e-02 8.63e-01
Release of Hh-Np from the secreting cell 8 8.34e-01 -4.29e-02 9.55e-01
FRS-mediated FGFR1 signaling 23 7.22e-01 -4.28e-02 8.99e-01
NRIF signals cell death from the nucleus 16 7.67e-01 4.27e-02 9.21e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 21 7.36e-01 4.25e-02 9.05e-01
Transport of RCbl within the body 8 8.36e-01 -4.23e-02 9.56e-01
Linoleic acid (LA) metabolism 8 8.36e-01 4.22e-02 9.56e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 38 6.52e-01 -4.22e-02 8.75e-01
Interleukin-12 signaling 43 6.32e-01 -4.22e-02 8.69e-01
Transport of small molecules 732 5.19e-02 -4.22e-02 3.80e-01
Negative regulation of activity of TFAP2 (AP-2) family transcription factors 10 8.18e-01 -4.21e-02 9.45e-01
Signaling by BMP 31 6.85e-01 -4.21e-02 8.86e-01
GABA receptor activation 60 5.73e-01 4.21e-02 8.46e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 7.33e-01 -4.20e-02 9.04e-01
SUMOylation 175 3.38e-01 -4.19e-02 7.12e-01
B-WICH complex positively regulates rRNA expression 54 5.95e-01 -4.18e-02 8.57e-01
Nucleotide biosynthesis 12 8.03e-01 4.16e-02 9.39e-01
Scavenging by Class B Receptors 6 8.60e-01 -4.15e-02 9.68e-01
SUMOylation of ubiquitinylation proteins 39 6.54e-01 4.15e-02 8.76e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 202 3.15e-01 -4.10e-02 7.03e-01
MHC class II antigen presentation 123 4.34e-01 -4.08e-02 7.77e-01
Toll Like Receptor 2 (TLR2) Cascade 115 4.49e-01 -4.08e-02 7.86e-01
Toll Like Receptor TLR1:TLR2 Cascade 115 4.49e-01 -4.08e-02 7.86e-01
ADP signalling through P2Y purinoceptor 12 22 7.40e-01 -4.08e-02 9.10e-01
Translation of Structural Proteins 9683701 29 7.04e-01 -4.08e-02 8.91e-01
Nuclear Envelope Breakdown 53 6.09e-01 4.06e-02 8.63e-01
Nuclear import of Rev protein 34 6.84e-01 4.04e-02 8.86e-01
DAP12 interactions 40 6.59e-01 4.03e-02 8.78e-01
RUNX2 regulates bone development 31 6.98e-01 -4.02e-02 8.90e-01
tRNA modification in the nucleus and cytosol 43 6.48e-01 4.02e-02 8.75e-01
Defective B3GALTL causes PpS 38 6.69e-01 -4.01e-02 8.82e-01
Metal ion SLC transporters 24 7.35e-01 -4.00e-02 9.05e-01
DSCAM interactions 11 8.19e-01 3.98e-02 9.46e-01
Androgen biosynthesis 11 8.20e-01 3.97e-02 9.46e-01
Vitamin D (calciferol) metabolism 12 8.12e-01 -3.96e-02 9.41e-01
Ion homeostasis 54 6.16e-01 -3.94e-02 8.63e-01
Signaling by TGFB family members 124 4.49e-01 -3.94e-02 7.86e-01
NOTCH2 intracellular domain regulates transcription 12 8.14e-01 3.93e-02 9.42e-01
CS/DS degradation 14 8.01e-01 -3.90e-02 9.38e-01
Regulation of PTEN gene transcription 61 5.99e-01 -3.89e-02 8.57e-01
Cytoprotection by HMOX1 60 6.02e-01 -3.89e-02 8.59e-01
PIP3 activates AKT signaling 287 2.58e-01 -3.88e-02 6.51e-01
Centrosome maturation 81 5.48e-01 -3.86e-02 8.30e-01
Recruitment of mitotic centrosome proteins and complexes 81 5.48e-01 -3.86e-02 8.30e-01
Nuclear Receptor transcription pathway 53 6.28e-01 -3.85e-02 8.67e-01
Disorders of transmembrane transporters 177 3.79e-01 3.83e-02 7.48e-01
Mitochondrial tRNA aminoacylation 20 7.68e-01 3.82e-02 9.21e-01
Attachment and Entry 9694614 19 7.73e-01 -3.81e-02 9.23e-01
IRAK1 recruits IKK complex 14 8.05e-01 -3.81e-02 9.39e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 8.05e-01 -3.81e-02 9.39e-01
FOXO-mediated transcription 66 5.93e-01 -3.80e-02 8.56e-01
RNA polymerase II transcribes snRNA genes 74 5.72e-01 3.80e-02 8.46e-01
Maturation of spike protein 9683686 5 8.83e-01 3.80e-02 9.76e-01
Transcriptional regulation by RUNX3 95 5.23e-01 3.79e-02 8.18e-01
Creation of C4 and C2 activators 14 8.06e-01 -3.79e-02 9.39e-01
Signaling by TGF-beta Receptor Complex 94 5.28e-01 -3.77e-02 8.20e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.89e-01 3.74e-02 9.34e-01
Processing of Intronless Pre-mRNAs 20 7.72e-01 3.74e-02 9.22e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 7.15e-01 3.73e-02 8.99e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 7.15e-01 3.73e-02 8.99e-01
Base-Excision Repair, AP Site Formation 40 6.85e-01 -3.70e-02 8.86e-01
G alpha (q) signalling events 216 3.48e-01 -3.70e-02 7.17e-01
Nectin/Necl trans heterodimerization 7 8.66e-01 3.69e-02 9.68e-01
Nef and signal transduction 8 8.58e-01 -3.66e-02 9.68e-01
Disease 1765 1.06e-02 -3.65e-02 1.93e-01
Downstream signaling of activated FGFR2 30 7.30e-01 -3.65e-02 9.01e-01
PCP/CE pathway 92 5.46e-01 3.64e-02 8.30e-01
Diseases associated with N-glycosylation of proteins 20 7.78e-01 3.64e-02 9.26e-01
Phospholipase C-mediated cascade; FGFR3 13 8.21e-01 -3.62e-02 9.47e-01
Cellular response to chemical stress 213 3.64e-01 -3.61e-02 7.35e-01
HSF1 activation 29 7.37e-01 -3.61e-02 9.05e-01
COPI-independent Golgi-to-ER retrograde traffic 51 6.56e-01 -3.61e-02 8.76e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 6.67e-01 3.59e-02 8.81e-01
FCERI mediated MAPK activation 32 7.27e-01 3.57e-02 9.00e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 6.93e-01 3.56e-02 8.90e-01
Toll Like Receptor 4 (TLR4) Cascade 144 4.62e-01 -3.55e-02 7.94e-01
FGFR1 ligand binding and activation 18 7.94e-01 3.55e-02 9.35e-01
RNA Polymerase II Pre-transcription Events 80 5.84e-01 3.54e-02 8.49e-01
Cardiogenesis 27 7.50e-01 -3.54e-02 9.14e-01
Assembly Of The HIV Virion 16 8.06e-01 -3.54e-02 9.39e-01
Synthesis of Lipoxins (LX) 6 8.81e-01 -3.54e-02 9.76e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 18 7.96e-01 3.52e-02 9.36e-01
activated TAK1 mediates p38 MAPK activation 23 7.71e-01 3.50e-02 9.22e-01
Cell Cycle 648 1.29e-01 3.49e-02 5.13e-01
Autophagy 148 4.66e-01 -3.47e-02 7.95e-01
Free fatty acids regulate insulin secretion 11 8.42e-01 -3.47e-02 9.60e-01
SUMOylation of RNA binding proteins 47 6.81e-01 -3.46e-02 8.86e-01
Translation of Structural Proteins 9694635 57 6.51e-01 3.46e-02 8.75e-01
Role of phospholipids in phagocytosis 25 7.65e-01 -3.45e-02 9.20e-01
Synthesis of diphthamide-EEF2 8 8.66e-01 -3.43e-02 9.68e-01
Maturation of spike protein 9694548 37 7.18e-01 3.43e-02 8.99e-01
Cell Cycle, Mitotic 520 1.82e-01 3.42e-02 5.96e-01
Metabolism of RNA 721 1.19e-01 3.40e-02 5.00e-01
Chaperone Mediated Autophagy 22 7.82e-01 3.40e-02 9.30e-01
Na+/Cl- dependent neurotransmitter transporters 19 7.98e-01 -3.39e-02 9.36e-01
Mitochondrial translation 93 5.74e-01 3.37e-02 8.47e-01
Activation of NMDA receptors and postsynaptic events 92 5.77e-01 3.37e-02 8.48e-01
Activation of RAC1 13 8.34e-01 -3.36e-02 9.55e-01
Integrin cell surface interactions 85 5.96e-01 -3.33e-02 8.57e-01
Inositol phosphate metabolism 48 6.91e-01 -3.32e-02 8.89e-01
Regulation of PLK1 Activity at G2/M Transition 87 5.93e-01 -3.32e-02 8.56e-01
Cyclin D associated events in G1 46 6.97e-01 3.31e-02 8.90e-01
G1 Phase 46 6.97e-01 3.31e-02 8.90e-01
Transcriptional regulation by RUNX1 208 4.10e-01 -3.31e-02 7.67e-01
Interleukin-4 and Interleukin-13 signaling 108 5.52e-01 3.31e-02 8.30e-01
SARS-CoV-1-host interactions 95 5.78e-01 3.30e-02 8.48e-01
Export of Viral Ribonucleoproteins from Nucleus 33 7.44e-01 3.29e-02 9.10e-01
Viral Messenger RNA Synthesis 44 7.06e-01 3.29e-02 8.92e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 55 6.75e-01 3.27e-02 8.86e-01
Nucleotide Excision Repair 109 5.55e-01 3.27e-02 8.32e-01
SARS-CoV-2-host interactions 196 4.31e-01 3.26e-02 7.77e-01
Activation of RAS in B cells 5 9.00e-01 -3.25e-02 9.80e-01
Toll-like Receptor Cascades 166 4.70e-01 -3.25e-02 7.95e-01
HCMV Early Events 103 5.69e-01 -3.25e-02 8.44e-01
Innate Immune System 1033 7.73e-02 3.25e-02 4.34e-01
Zinc transporters 15 8.28e-01 -3.24e-02 9.51e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 8.23e-01 -3.24e-02 9.47e-01
FGFR1c ligand binding and activation 14 8.34e-01 -3.24e-02 9.55e-01
Activated NOTCH1 Transmits Signal to the Nucleus 31 7.56e-01 -3.22e-02 9.17e-01
Creatine metabolism 10 8.60e-01 3.22e-02 9.68e-01
SHC-mediated cascade:FGFR1 21 7.99e-01 3.21e-02 9.37e-01
Sensory processing of sound by inner hair cells of the cochlea 67 6.51e-01 -3.20e-02 8.75e-01
Respiratory syncytial virus (RSV) genome replication, transcription and translation 16 8.25e-01 3.18e-02 9.50e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 7.23e-01 -3.16e-02 8.99e-01
HIV Transcription Elongation 42 7.23e-01 -3.16e-02 8.99e-01
Tat-mediated elongation of the HIV-1 transcript 42 7.23e-01 -3.16e-02 8.99e-01
Glucuronidation 22 7.98e-01 -3.16e-02 9.36e-01
Deadenylation of mRNA 22 7.98e-01 -3.16e-02 9.36e-01
Metabolism of porphyrins 28 7.73e-01 3.15e-02 9.22e-01
CD209 (DC-SIGN) signaling 21 8.03e-01 -3.15e-02 9.39e-01
MAPK1/MAPK3 signaling 279 3.69e-01 -3.13e-02 7.39e-01
Transcriptional regulation by small RNAs 70 6.52e-01 -3.12e-02 8.75e-01
Degradation of beta-catenin by the destruction complex 85 6.19e-01 3.12e-02 8.63e-01
Signaling by Retinoic Acid 43 7.25e-01 3.10e-02 9.00e-01
Glycogen metabolism 25 7.90e-01 3.07e-02 9.34e-01
Phosphate bond hydrolysis by NUDT proteins 7 8.88e-01 -3.06e-02 9.77e-01
Mitochondrial translation elongation 87 6.22e-01 3.06e-02 8.63e-01
ECM proteoglycans 76 6.46e-01 -3.05e-02 8.75e-01
Formation of TC-NER Pre-Incision Complex 52 7.04e-01 3.04e-02 8.91e-01
Macroautophagy 133 5.45e-01 -3.04e-02 8.30e-01
Transcriptional regulation of granulopoiesis 53 7.02e-01 -3.03e-02 8.91e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 78 6.47e-01 3.00e-02 8.75e-01
Diseases of Base Excision Repair 5 9.08e-01 -3.00e-02 9.81e-01
Pyruvate metabolism 31 7.73e-01 -3.00e-02 9.22e-01
Deadenylation-dependent mRNA decay 53 7.07e-01 -2.98e-02 8.92e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 8.65e-01 2.96e-02 9.68e-01
Heme degradation 16 8.38e-01 2.95e-02 9.57e-01
Assembly of the ORC complex at the origin of replication 32 7.74e-01 -2.93e-02 9.23e-01
Attenuation phase 26 7.96e-01 -2.93e-02 9.36e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 29 7.85e-01 -2.92e-02 9.32e-01
Activation of AMPK downstream of NMDARs 27 7.93e-01 2.92e-02 9.35e-01
Inwardly rectifying K+ channels 35 7.66e-01 2.91e-02 9.20e-01
Neurexins and neuroligins 57 7.05e-01 2.90e-02 8.91e-01
RNA Polymerase III Transcription Initiation 36 7.64e-01 -2.90e-02 9.20e-01
MET activates RAS signaling 11 8.68e-01 -2.90e-02 9.68e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 63 6.91e-01 2.89e-02 8.89e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 35 7.68e-01 -2.88e-02 9.21e-01
Regulation of HMOX1 expression and activity 5 9.11e-01 2.88e-02 9.81e-01
Interleukin-37 signaling 21 8.20e-01 -2.87e-02 9.46e-01
Signaling by NOTCH4 82 6.55e-01 2.85e-02 8.76e-01
M Phase 377 3.43e-01 2.84e-02 7.12e-01
Negative regulators of DDX58/IFIH1 signaling 35 7.71e-01 2.84e-02 9.22e-01
RAF/MAP kinase cascade 273 4.21e-01 -2.83e-02 7.69e-01
Axonal growth inhibition (RHOA activation) 9 8.83e-01 -2.83e-02 9.76e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 7.98e-01 -2.80e-02 9.36e-01
Pentose phosphate pathway 15 8.53e-01 2.77e-02 9.65e-01
Hemostasis 592 2.50e-01 -2.76e-02 6.47e-01
LGI-ADAM interactions 14 8.59e-01 2.75e-02 9.68e-01
Generic Transcription Pathway 1221 1.10e-01 2.71e-02 4.93e-01
Lipophagy 9 8.88e-01 -2.70e-02 9.77e-01
ERK/MAPK targets 22 8.26e-01 -2.70e-02 9.50e-01
Scavenging of heme from plasma 12 8.72e-01 -2.68e-02 9.70e-01
rRNA processing in the mitochondrion 10 8.83e-01 2.68e-02 9.76e-01
Metabolism of cofactors 19 8.40e-01 2.68e-02 9.59e-01
Mitotic Prometaphase 200 5.16e-01 2.67e-02 8.15e-01
FCGR3A-mediated IL10 synthesis 38 7.77e-01 -2.65e-02 9.26e-01
Transcriptional Regulation by NPAS4 33 7.92e-01 -2.65e-02 9.35e-01
Membrane binding and targetting of GAG proteins 14 8.66e-01 -2.61e-02 9.68e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 8.66e-01 -2.61e-02 9.68e-01
Recruitment of NuMA to mitotic centrosomes 93 6.65e-01 -2.60e-02 8.80e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 93 6.66e-01 2.59e-02 8.81e-01
Amplification of signal from the kinetochores 93 6.66e-01 2.59e-02 8.81e-01
Processing of Capped Intronless Pre-mRNA 29 8.11e-01 2.57e-02 9.40e-01
p75NTR recruits signalling complexes 13 8.73e-01 2.56e-02 9.70e-01
O-linked glycosylation 112 6.40e-01 -2.55e-02 8.75e-01
Recycling pathway of L1 47 7.63e-01 2.55e-02 9.20e-01
Phospholipase C-mediated cascade; FGFR4 15 8.65e-01 -2.54e-02 9.68e-01
DNA Double-Strand Break Repair 145 5.99e-01 -2.53e-02 8.57e-01
RNA Polymerase II Transcription 1344 1.22e-01 2.51e-02 5.02e-01
Sphingolipid de novo biosynthesis 37 7.93e-01 2.49e-02 9.35e-01
Post-translational protein modification 1401 1.19e-01 -2.48e-02 5.00e-01
SLBP independent Processing of Histone Pre-mRNAs 10 8.92e-01 2.47e-02 9.77e-01
RUNX2 regulates genes involved in cell migration 8 9.04e-01 -2.47e-02 9.80e-01
L1CAM interactions 119 6.44e-01 2.45e-02 8.75e-01
Metabolic disorders of biological oxidation enzymes 34 8.05e-01 2.45e-02 9.39e-01
Sialic acid metabolism 33 8.09e-01 -2.43e-02 9.40e-01
Nuclear events mediated by NFE2L2 96 6.83e-01 2.41e-02 8.86e-01
Glycoprotein hormones 9 9.00e-01 2.41e-02 9.80e-01
Infectious disease 974 2.03e-01 -2.41e-02 6.08e-01
Late SARS-CoV-2 Infection Events 70 7.29e-01 2.40e-02 9.00e-01
Iron uptake and transport 58 7.52e-01 2.40e-02 9.15e-01
ATF6 (ATF6-alpha) activates chaperones 12 8.86e-01 -2.39e-02 9.77e-01
Transcriptional Regulation by MECP2 63 7.44e-01 2.38e-02 9.10e-01
Cellular Senescence 161 6.03e-01 -2.37e-02 8.59e-01
trans-Golgi Network Vesicle Budding 71 7.30e-01 -2.37e-02 9.01e-01
Negative regulation of MET activity 21 8.52e-01 -2.36e-02 9.65e-01
PI-3K cascade:FGFR1 21 8.52e-01 -2.35e-02 9.65e-01
Metabolism of amino acids and derivatives 367 4.41e-01 2.34e-02 7.80e-01
Nuclear Pore Complex (NPC) Disassembly 36 8.08e-01 2.34e-02 9.40e-01
SARS-CoV Infections 406 4.19e-01 -2.34e-02 7.69e-01
EML4 and NUDC in mitotic spindle formation 114 6.68e-01 2.32e-02 8.82e-01
Acyl chain remodeling of CL 5 9.29e-01 -2.31e-02 9.86e-01
Urea cycle 10 9.01e-01 2.28e-02 9.80e-01
Cellular responses to stimuli 781 2.79e-01 -2.28e-02 6.74e-01
Induction of Cell-Cell Fusion 13 8.88e-01 -2.25e-02 9.77e-01
DNA Damage/Telomere Stress Induced Senescence 57 7.69e-01 -2.25e-02 9.21e-01
Kinesins 60 7.63e-01 -2.25e-02 9.20e-01
Phase II - Conjugation of compounds 104 6.92e-01 2.24e-02 8.89e-01
Signaling by RNF43 mutants 8 9.12e-01 2.24e-02 9.81e-01
Defects in vitamin and cofactor metabolism 21 8.60e-01 2.23e-02 9.68e-01
Regulation of IFNG signaling 14 8.85e-01 2.23e-02 9.77e-01
SUMOylation of DNA damage response and repair proteins 77 7.35e-01 -2.23e-02 9.05e-01
Meiotic recombination 50 7.86e-01 2.22e-02 9.32e-01
Neddylation 242 5.54e-01 2.21e-02 8.32e-01
Cytokine Signaling in Immune system 751 3.09e-01 -2.18e-02 6.97e-01
CRMPs in Sema3A signaling 16 8.81e-01 -2.17e-02 9.76e-01
Synthesis of IP2, IP, and Ins in the cytosol 14 8.91e-01 -2.12e-02 9.77e-01
Cellular responses to stress 767 3.19e-01 -2.11e-02 7.03e-01
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 8 9.18e-01 -2.10e-02 9.81e-01
G alpha (s) signalling events 156 6.52e-01 2.09e-02 8.75e-01
Gene expression (Transcription) 1512 1.83e-01 2.04e-02 5.98e-01
Transcriptional Regulation by TP53 359 5.06e-01 -2.04e-02 8.13e-01
Signal regulatory protein family interactions 15 8.91e-01 -2.04e-02 9.77e-01
Interaction With Cumulus Cells And The Zona Pellucida 11 9.08e-01 -2.02e-02 9.81e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 77 7.60e-01 2.01e-02 9.19e-01
Synthesis of Dolichyl-phosphate 6 9.32e-01 -2.01e-02 9.86e-01
COPI-mediated anterograde transport 100 7.30e-01 -2.00e-02 9.01e-01
KEAP1-NFE2L2 pathway 129 6.95e-01 -2.00e-02 8.90e-01
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 12 9.05e-01 1.99e-02 9.81e-01
Developmental Biology 1238 2.40e-01 1.98e-02 6.39e-01
Formation of the Early Elongation Complex 32 8.47e-01 -1.96e-02 9.65e-01
Formation of the HIV-1 Early Elongation Complex 32 8.47e-01 -1.96e-02 9.65e-01
RNA Polymerase I Promoter Escape 53 8.05e-01 1.96e-02 9.39e-01
Postmitotic nuclear pore complex (NPC) reformation 27 8.60e-01 1.96e-02 9.68e-01
Maturation of hRSV A proteins 13 9.04e-01 1.93e-02 9.80e-01
TCF dependent signaling in response to WNT 196 6.43e-01 -1.92e-02 8.75e-01
Thyroxine biosynthesis 10 9.16e-01 -1.91e-02 9.81e-01
MAPK family signaling cascades 321 5.57e-01 -1.91e-02 8.33e-01
Activation of SMO 18 8.90e-01 -1.89e-02 9.77e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 8.93e-01 1.89e-02 9.77e-01
Presynaptic function of Kainate receptors 21 8.82e-01 -1.88e-02 9.76e-01
Signaling by activated point mutants of FGFR1 11 9.14e-01 -1.87e-02 9.81e-01
Activation of G protein gated Potassium channels 29 8.62e-01 -1.87e-02 9.68e-01
G protein gated Potassium channels 29 8.62e-01 -1.87e-02 9.68e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 29 8.62e-01 -1.87e-02 9.68e-01
Negative regulation of FGFR1 signaling 33 8.53e-01 -1.86e-02 9.65e-01
Defective factor IX causes hemophilia B 9 9.23e-01 1.86e-02 9.83e-01
Presynaptic depolarization and calcium channel opening 12 9.12e-01 -1.84e-02 9.81e-01
mRNA 3’-end processing 58 8.09e-01 1.83e-02 9.40e-01
Negative regulation of FGFR2 signaling 34 8.54e-01 -1.82e-02 9.65e-01
Citric acid cycle (TCA cycle) 22 8.82e-01 -1.82e-02 9.76e-01
Dissolution of Fibrin Clot 13 9.10e-01 -1.82e-02 9.81e-01
PTK6 promotes HIF1A stabilization 7 9.34e-01 -1.81e-02 9.86e-01
Small interfering RNA (siRNA) biogenesis 9 9.26e-01 1.80e-02 9.84e-01
FGFR4 ligand binding and activation 14 9.08e-01 1.79e-02 9.81e-01
Signaling by ALK 28 8.70e-01 -1.79e-02 9.69e-01
Activated NTRK2 signals through FRS2 and FRS3 11 9.19e-01 1.78e-02 9.81e-01
Regulation of HSF1-mediated heat shock response 81 7.82e-01 1.78e-02 9.30e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 20 8.91e-01 -1.77e-02 9.77e-01
Pyrimidine catabolism 12 9.15e-01 1.77e-02 9.81e-01
Signaling by NTRK1 (TRKA) 115 7.43e-01 -1.77e-02 9.10e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 8.64e-01 1.76e-02 9.68e-01
NoRC negatively regulates rRNA expression 68 8.03e-01 -1.75e-02 9.39e-01
Organelle biogenesis and maintenance 285 6.11e-01 -1.75e-02 8.63e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.21e-01 -1.73e-02 9.83e-01
Amino acids regulate mTORC1 52 8.30e-01 1.73e-02 9.52e-01
RHO GTPases activate IQGAPs 30 8.70e-01 -1.72e-02 9.69e-01
CD28 dependent Vav1 pathway 12 9.19e-01 -1.70e-02 9.81e-01
HIV Infection 229 6.60e-01 1.69e-02 8.78e-01
Glucagon-type ligand receptors 32 8.70e-01 -1.67e-02 9.69e-01
Initiation of Nuclear Envelope (NE) Reformation 19 9.01e-01 -1.65e-02 9.80e-01
G alpha (i) signalling events 313 6.20e-01 1.63e-02 8.63e-01
EPHB-mediated forward signaling 42 8.56e-01 1.62e-02 9.66e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 30 8.79e-01 1.60e-02 9.76e-01
Activation of NIMA Kinases NEK9, NEK6, NEK7 7 9.42e-01 -1.60e-02 9.88e-01
PI5P Regulates TP53 Acetylation 8 9.38e-01 -1.59e-02 9.87e-01
Phospholipase C-mediated cascade: FGFR1 16 9.12e-01 1.59e-02 9.81e-01
Processing of DNA double-strand break ends 76 8.11e-01 1.59e-02 9.40e-01
RNA Polymerase II Transcription Termination 67 8.23e-01 1.58e-02 9.47e-01
Post-chaperonin tubulin folding pathway 22 8.99e-01 1.57e-02 9.80e-01
Platelet degranulation 126 7.63e-01 -1.56e-02 9.20e-01
Platelet calcium homeostasis 28 8.87e-01 1.56e-02 9.77e-01
Sensory processing of sound 75 8.17e-01 -1.55e-02 9.45e-01
MTOR signalling 41 8.67e-01 -1.52e-02 9.68e-01
Adaptive Immune System 755 4.78e-01 1.52e-02 8.00e-01
MET activates RAP1 and RAC1 11 9.31e-01 1.51e-02 9.86e-01
Metabolism of non-coding RNA 53 8.53e-01 -1.47e-02 9.65e-01
snRNP Assembly 53 8.53e-01 -1.47e-02 9.65e-01
Branched-chain amino acid catabolism 21 9.08e-01 -1.46e-02 9.81e-01
Myogenesis 29 8.92e-01 -1.45e-02 9.77e-01
FRS-mediated FGFR2 signaling 25 9.01e-01 -1.44e-02 9.80e-01
Nuclear Envelope (NE) Reassembly 74 8.30e-01 -1.44e-02 9.52e-01
Interleukin-35 Signalling 12 9.31e-01 -1.44e-02 9.86e-01
Multifunctional anion exchangers 9 9.41e-01 -1.43e-02 9.88e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 9.31e-01 1.39e-02 9.86e-01
Signaling by GPCR 699 5.34e-01 1.38e-02 8.21e-01
Protein localization 161 7.65e-01 -1.36e-02 9.20e-01
Synthesis of PIPs at the early endosome membrane 16 9.25e-01 1.36e-02 9.84e-01
Transferrin endocytosis and recycling 30 8.98e-01 -1.35e-02 9.80e-01
MASTL Facilitates Mitotic Progression 10 9.41e-01 -1.34e-02 9.88e-01
FGFR3 mutant receptor activation 12 9.36e-01 1.34e-02 9.86e-01
Signaling by activated point mutants of FGFR3 12 9.36e-01 1.34e-02 9.86e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 76 8.42e-01 1.32e-02 9.60e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 12 9.37e-01 -1.32e-02 9.87e-01
Ion channel transport 183 7.60e-01 1.31e-02 9.19e-01
SUMOylation of intracellular receptors 30 9.02e-01 -1.29e-02 9.80e-01
PTK6 Regulates Cell Cycle 6 9.56e-01 1.29e-02 9.94e-01
Negative epigenetic regulation of rRNA expression 71 8.51e-01 -1.29e-02 9.65e-01
Asparagine N-linked glycosylation 303 7.00e-01 -1.29e-02 8.90e-01
Signaling by NTRK2 (TRKB) 25 9.11e-01 1.29e-02 9.81e-01
Metabolism of nitric oxide: NOS3 activation and regulation 14 9.34e-01 -1.28e-02 9.86e-01
Protein-protein interactions at synapses 88 8.38e-01 1.26e-02 9.57e-01
Transport of the SLBP Dependant Mature mRNA 36 8.96e-01 1.26e-02 9.79e-01
Cellular response to heat stress 99 8.29e-01 -1.25e-02 9.52e-01
Class I MHC mediated antigen processing & presentation 378 6.77e-01 -1.25e-02 8.86e-01
Intraflagellar transport 51 8.78e-01 1.24e-02 9.75e-01
mRNA Editing 10 9.46e-01 1.23e-02 9.89e-01
Signaling by FGFR2 in disease 43 8.89e-01 -1.23e-02 9.77e-01
SARS-CoV-2 Infection 291 7.20e-01 1.22e-02 8.99e-01
VxPx cargo-targeting to cilium 21 9.23e-01 1.22e-02 9.83e-01
Regulation of TP53 Activity through Methylation 19 9.27e-01 1.21e-02 9.85e-01
FLT3 signaling through SRC family kinases 6 9.59e-01 1.20e-02 9.97e-01
Transcriptional regulation of white adipocyte differentiation 84 8.51e-01 1.19e-02 9.65e-01
Sodium-coupled sulphate, di- and tri-carboxylate transporters 5 9.64e-01 -1.18e-02 9.97e-01
Fanconi Anemia Pathway 35 9.04e-01 1.17e-02 9.80e-01
Interleukin-1 signaling 114 8.29e-01 -1.17e-02 9.52e-01
G2/M DNA damage checkpoint 73 8.64e-01 1.16e-02 9.68e-01
MicroRNA (miRNA) biogenesis 26 9.19e-01 -1.15e-02 9.81e-01
Complex I biogenesis 51 8.89e-01 -1.13e-02 9.77e-01
GDP-fucose biosynthesis 6 9.63e-01 1.10e-02 9.97e-01
MAP kinase activation 63 8.82e-01 1.08e-02 9.76e-01
Scavenging by Class A Receptors 19 9.36e-01 1.07e-02 9.86e-01
Transport of the SLBP independent Mature mRNA 35 9.13e-01 1.07e-02 9.81e-01
Nephrin family interactions 22 9.32e-01 -1.06e-02 9.86e-01
Golgi Associated Vesicle Biogenesis 55 8.92e-01 -1.05e-02 9.77e-01
RNA Polymerase III Chain Elongation 18 9.40e-01 1.02e-02 9.88e-01
MET receptor recycling 10 9.56e-01 -1.01e-02 9.94e-01
RHO GTPases Activate NADPH Oxidases 24 9.32e-01 -1.00e-02 9.86e-01
HDR through MMEJ (alt-NHEJ) 12 9.52e-01 1.00e-02 9.93e-01
Maternal to zygotic transition (MZT) 97 8.66e-01 -9.92e-03 9.68e-01
Glycogen storage diseases 16 9.45e-01 9.90e-03 9.89e-01
SUMOylation of chromatin organization proteins 57 8.98e-01 9.84e-03 9.80e-01
Gap junction assembly 36 9.19e-01 -9.79e-03 9.81e-01
IKK complex recruitment mediated by RIP1 23 9.35e-01 -9.76e-03 9.86e-01
mRNA Splicing 213 8.09e-01 9.60e-03 9.40e-01
Physiological factors 14 9.50e-01 -9.59e-03 9.93e-01
Activation of the TFAP2 (AP-2) family of transcription factors 12 9.55e-01 9.47e-03 9.94e-01
Homology Directed Repair 115 8.62e-01 9.40e-03 9.68e-01
SUMOylation of DNA replication proteins 46 9.13e-01 -9.30e-03 9.81e-01
Processing of Capped Intron-Containing Pre-mRNA 282 7.88e-01 9.29e-03 9.33e-01
SUMOylation of SUMOylation proteins 35 9.24e-01 9.26e-03 9.84e-01
Aggrephagy 41 9.19e-01 9.16e-03 9.81e-01
Platelet Adhesion to exposed collagen 16 9.49e-01 9.15e-03 9.92e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 109 8.70e-01 9.09e-03 9.69e-01
Carboxyterminal post-translational modifications of tubulin 43 9.19e-01 8.97e-03 9.81e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 9.19e-01 8.91e-03 9.81e-01
RSK activation 7 9.68e-01 -8.80e-03 9.98e-01
Nervous system development 577 7.18e-01 -8.80e-03 8.99e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 70 9.03e-01 8.40e-03 9.80e-01
Oncogene Induced Senescence 35 9.32e-01 -8.34e-03 9.86e-01
Interleukin-17 signaling 71 9.06e-01 8.09e-03 9.81e-01
Factors involved in megakaryocyte development and platelet production 149 8.68e-01 -7.91e-03 9.68e-01
Ub-specific processing proteases 187 8.53e-01 -7.83e-03 9.65e-01
RUNX3 regulates p14-ARF 10 9.67e-01 7.62e-03 9.98e-01
Beta-catenin independent WNT signaling 146 8.74e-01 -7.58e-03 9.71e-01
RUNX1 regulates estrogen receptor mediated transcription 6 9.75e-01 -7.48e-03 9.98e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 13 9.63e-01 7.48e-03 9.97e-01
alpha-linolenic acid (ALA) metabolism 13 9.63e-01 7.48e-03 9.97e-01
Metabolism of proteins 1979 5.82e-01 -7.47e-03 8.49e-01
Response to elevated platelet cytosolic Ca2+ 131 8.86e-01 -7.25e-03 9.77e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 9.35e-01 7.24e-03 9.86e-01
NOD1/2 Signaling Pathway 36 9.40e-01 7.23e-03 9.88e-01
Axon guidance 551 7.72e-01 -7.22e-03 9.22e-01
Beta oxidation of octanoyl-CoA to hexanoyl-CoA 5 9.79e-01 -6.92e-03 9.98e-01
Senescence-Associated Secretory Phenotype (SASP) 75 9.18e-01 -6.90e-03 9.81e-01
Immune System 1984 6.12e-01 6.88e-03 8.63e-01
RHOT1 GTPase cycle 5 9.79e-01 6.87e-03 9.98e-01
MET activates PI3K/AKT signaling 6 9.77e-01 -6.76e-03 9.98e-01
ISG15 antiviral mechanism 74 9.23e-01 -6.49e-03 9.83e-01
PKR-mediated signaling 73 9.24e-01 -6.44e-03 9.84e-01
tRNA Aminoacylation 40 9.44e-01 -6.41e-03 9.89e-01
Termination of O-glycan biosynthesis 25 9.56e-01 6.33e-03 9.94e-01
Telomere Maintenance 89 9.18e-01 -6.29e-03 9.81e-01
Chondroitin sulfate biosynthesis 20 9.62e-01 -6.23e-03 9.97e-01
Cell surface interactions at the vascular wall 131 9.02e-01 -6.22e-03 9.80e-01
p75NTR regulates axonogenesis 10 9.74e-01 6.06e-03 9.98e-01
Signaling by LRP5 mutants 6 9.81e-01 -5.75e-03 9.98e-01
GPCR downstream signalling 626 8.06e-01 -5.75e-03 9.39e-01
PI-3K cascade:FGFR2 23 9.63e-01 5.64e-03 9.97e-01
Rev-mediated nuclear export of HIV RNA 35 9.55e-01 5.52e-03 9.94e-01
Interleukin-12 family signaling 53 9.45e-01 5.52e-03 9.89e-01
mRNA Splicing - Major Pathway 202 8.93e-01 5.49e-03 9.77e-01
STAT3 nuclear events downstream of ALK signaling 11 9.75e-01 -5.43e-03 9.98e-01
ROBO receptors bind AKAP5 9 9.78e-01 5.32e-03 9.98e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 9.70e-01 -5.26e-03 9.98e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 9.70e-01 -5.26e-03 9.98e-01
Post NMDA receptor activation events 79 9.36e-01 5.26e-03 9.86e-01
Cilium Assembly 196 9.02e-01 -5.08e-03 9.80e-01
Nephron development 13 9.75e-01 -5.04e-03 9.98e-01
PTEN Regulation 158 9.14e-01 -5.00e-03 9.81e-01
Interactions of Rev with host cellular proteins 37 9.61e-01 4.67e-03 9.97e-01
Ficolins bind to repetitive carbohydrate structures on the target cell surface 5 9.86e-01 -4.51e-03 9.98e-01
Classical antibody-mediated complement activation 6 9.85e-01 -4.44e-03 9.98e-01
Synthesis of substrates in N-glycan biosythesis 63 9.51e-01 -4.43e-03 9.93e-01
DNA Repair 302 8.96e-01 -4.38e-03 9.79e-01
TP53 Regulates Metabolic Genes 86 9.45e-01 4.34e-03 9.89e-01
RUNX2 regulates osteoblast differentiation 24 9.71e-01 4.23e-03 9.98e-01
Sodium/Proton exchangers 9 9.83e-01 -4.20e-03 9.98e-01
eNOS activation 10 9.82e-01 -4.06e-03 9.98e-01
Neurotransmitter clearance 10 9.83e-01 -3.83e-03 9.98e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 73 9.56e-01 3.77e-03 9.94e-01
SARS-CoV-1 Infection 140 9.42e-01 3.58e-03 9.88e-01
Endogenous sterols 27 9.75e-01 -3.54e-03 9.98e-01
Intra-Golgi traffic 44 9.68e-01 3.48e-03 9.98e-01
Signaling by FGFR2 IIIa TM 19 9.80e-01 -3.34e-03 9.98e-01
Selective autophagy 78 9.62e-01 -3.16e-03 9.97e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 9.78e-01 -3.12e-03 9.98e-01
Late Phase of HIV Life Cycle 135 9.51e-01 -3.03e-03 9.93e-01
Neutrophil degranulation 474 9.11e-01 2.99e-03 9.81e-01
NFE2L2 regulating inflammation associated genes 5 9.91e-01 2.96e-03 9.98e-01
Vitamin B2 (riboflavin) metabolism 7 9.89e-01 -2.92e-03 9.98e-01
Dopamine receptors 5 9.91e-01 -2.89e-03 9.98e-01
SHC-mediated cascade:FGFR3 18 9.83e-01 -2.85e-03 9.98e-01
HIV Life Cycle 148 9.53e-01 -2.78e-03 9.94e-01
Synthesis of PIPs at the late endosome membrane 11 9.87e-01 2.75e-03 9.98e-01
Regulation of pyruvate dehydrogenase (PDH) complex 16 9.85e-01 2.70e-03 9.98e-01
Meiosis 82 9.67e-01 2.68e-03 9.98e-01
Acyl chain remodelling of PI 17 9.85e-01 -2.68e-03 9.98e-01
Downregulation of TGF-beta receptor signaling 26 9.83e-01 2.37e-03 9.98e-01
Antigen processing: Ubiquitination & Proteasome degradation 306 9.44e-01 -2.32e-03 9.89e-01
Signaling by NTRKs 134 9.65e-01 2.19e-03 9.98e-01
Passive transport by Aquaporins 13 9.89e-01 -2.16e-03 9.98e-01
Insulin receptor recycling 29 9.84e-01 -2.10e-03 9.98e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 9.83e-01 2.04e-03 9.98e-01
SHC-mediated cascade:FGFR4 20 9.88e-01 1.91e-03 9.98e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 9.92e-01 -1.87e-03 9.98e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.86e-01 1.87e-03 9.98e-01
Fatty acyl-CoA biosynthesis 38 9.85e-01 1.76e-03 9.98e-01
Signaling by Hedgehog 149 9.71e-01 1.74e-03 9.98e-01
N-glycan antennae elongation in the medial/trans-Golgi 26 9.89e-01 1.55e-03 9.98e-01
Base Excision Repair 68 9.83e-01 -1.45e-03 9.98e-01
Synthesis of pyrophosphates in the cytosol 10 9.94e-01 1.42e-03 9.98e-01
Interleukin-1 family signaling 152 9.76e-01 -1.40e-03 9.98e-01
Reproduction 119 9.80e-01 1.34e-03 9.98e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 9.90e-01 -1.13e-03 9.98e-01
Cellular hexose transport 22 9.93e-01 -1.11e-03 9.98e-01
RHOBTB2 GTPase cycle 23 9.93e-01 -1.11e-03 9.98e-01
Mitochondrial protein degradation 87 9.86e-01 -1.09e-03 9.98e-01
Formation of RNA Pol II elongation complex 57 9.89e-01 -1.06e-03 9.98e-01
RNA Polymerase II Transcription Elongation 57 9.89e-01 -1.06e-03 9.98e-01
Lysosphingolipid and LPA receptors 14 9.95e-01 -9.93e-04 9.98e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 21 9.94e-01 -9.46e-04 9.98e-01
Gene Silencing by RNA 104 9.88e-01 -8.80e-04 9.98e-01
RHO GTPases Activate Formins 137 9.87e-01 -7.90e-04 9.98e-01
Activation of Matrix Metalloproteinases 32 9.94e-01 -7.09e-04 9.98e-01
Transport of Mature Transcript to Cytoplasm 82 9.93e-01 5.81e-04 9.98e-01
Deubiquitination 261 9.88e-01 5.60e-04 9.98e-01
Signaling by Interleukins 448 9.86e-01 4.72e-04 9.98e-01
Early Phase of HIV Life Cycle 14 9.98e-01 4.41e-04 9.99e-01
Signaling by NOTCH2 33 9.97e-01 4.02e-04 9.99e-01
Sensory processing of sound by outer hair cells of the cochlea 53 9.97e-01 2.65e-04 9.99e-01
Netrin-1 signaling 49 9.98e-01 -1.70e-04 9.99e-01
Trafficking and processing of endosomal TLR 13 9.99e-01 1.50e-04 9.99e-01
IRF3-mediated induction of type I IFN 13 9.99e-01 -1.17e-04 9.99e-01
Viral Infection Pathways 786 9.98e-01 5.18e-05 9.99e-01


Detailed Gene set reports



Fatty acids

Fatty acids
573
set Fatty acids
setSize 15
pANOVA 1.27e-06
s.dist 0.722
p.adjustANOVA 0.00051



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP4F2 11778
CYP2A7 11465
CYP4B1 11439
CYP4F8 11297
CYP2A13 11292
CYP4F12 10773
CYP2F1 10756
CYP4F3 10723
CYP2B6 10584
CYP4F22 10494
CYP4F11 10463
CYP4A11 8201
CYP2D6 7364
CYP4A22 1397
CYP2J2 -7969

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All member genes
GeneID Gene Rank
CYP4F2 11778
CYP2A7 11465
CYP4B1 11439
CYP4F8 11297
CYP2A13 11292
CYP4F12 10773
CYP2F1 10756
CYP4F3 10723
CYP2B6 10584
CYP4F22 10494
CYP4F11 10463
CYP4A11 8201
CYP2D6 7364
CYP4A22 1397
CYP2J2 -7969


Eicosanoids

Eicosanoids
499
set Eicosanoids
setSize 12
pANOVA 5.25e-05
s.dist 0.674
p.adjustANOVA 0.00704



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP4F2 11778
CYP4B1 11439
CYP4F8 11297
CYP4F12 10773
CYP4F3 10723
CYP4F22 10494
CYP4F11 10463
CYP4A11 8201
CYP8B1 4523
TBXAS1 4322
PTGIS 1992
CYP4A22 1397

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F2 11778
CYP4B1 11439
CYP4F8 11297
CYP4F12 10773
CYP4F3 10723
CYP4F22 10494
CYP4F11 10463
CYP4A11 8201
CYP8B1 4523
TBXAS1 4322
PTGIS 1992
CYP4A22 1397


Amino Acid conjugation

Amino Acid conjugation
104
set Amino Acid conjugation
setSize 9
pANOVA 0.000838
s.dist 0.643
p.adjustANOVA 0.0562



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSM2B 11530
ACSM4 11437
ACSM1 11167
ACSM2A 10922
ACSM5 10536
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSM2B 11530
ACSM4 11437
ACSM1 11167
ACSM2A 10922
ACSM5 10536
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926


Conjugation of carboxylic acids

Conjugation of carboxylic acids
307
set Conjugation of carboxylic acids
setSize 9
pANOVA 0.000838
s.dist 0.643
p.adjustANOVA 0.0562



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSM2B 11530
ACSM4 11437
ACSM1 11167
ACSM2A 10922
ACSM5 10536
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSM2B 11530
ACSM4 11437
ACSM1 11167
ACSM2A 10922
ACSM5 10536
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926


Conjugation of salicylate with glycine

Conjugation of salicylate with glycine
308
set Conjugation of salicylate with glycine
setSize 8
pANOVA 0.003
s.dist 0.606
p.adjustANOVA 0.0974



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSM2B 11530
ACSM4 11437
ACSM2A 10922
ACSM5 10536
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSM2B 11530
ACSM4 11437
ACSM2A 10922
ACSM5 10536
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926


Type I hemidesmosome assembly

Type I hemidesmosome assembly
1915
set Type I hemidesmosome assembly
setSize 11
pANOVA 0.000779
s.dist -0.585
p.adjustANOVA 0.056



Top enriched genes

Top 20 genes
GeneID Gene Rank
KRT14 -10752
CD151 -10355
KRT5 -10178
LAMC2 -9981
LAMB3 -9811
ITGB4 -8918
PLEC -7586
COL17A1 -4278
DST -1462
LAMA3 1182
ITGA6 2017

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KRT14 -10752
CD151 -10355
KRT5 -10178
LAMC2 -9981
LAMB3 -9811
ITGB4 -8918
PLEC -7586
COL17A1 -4278
DST -1462
LAMA3 1182
ITGA6 2017


RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
1372
set RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
setSize 8
pANOVA 0.00446
s.dist 0.581
p.adjustANOVA 0.118



Top enriched genes

Top 20 genes
GeneID Gene Rank
CTSK 10173
CTSV 9371
SERPINB13 9044
SOCS4 8735
SOCS3 8606
CBFB 8016
CTSL 5264
RUNX1 -2874

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CTSK 10173
CTSV 9371
SERPINB13 9044
SOCS4 8735
SOCS3 8606
CBFB 8016
CTSL 5264
RUNX1 -2874


ChREBP activates metabolic gene expression

ChREBP activates metabolic gene expression
263
set ChREBP activates metabolic gene expression
setSize 8
pANOVA 0.00685
s.dist -0.552
p.adjustANOVA 0.155



Top enriched genes

Top 20 genes
GeneID Gene Rank
FASN -9592
MLXIPL -8921
AGPAT1 -7134
ACACB -5352
MLX -5191
ACACA -4970
ACLY -4350
PKLR -2462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FASN -9592
MLXIPL -8921
AGPAT1 -7134
ACACB -5352
MLX -5191
ACACA -4970
ACLY -4350
PKLR -2462


Formyl peptide receptors bind formyl peptides and many other ligands

Formyl peptide receptors bind formyl peptides and many other ligands
610
set Formyl peptide receptors bind formyl peptides and many other ligands
setSize 8
pANOVA 0.00824
s.dist 0.539
p.adjustANOVA 0.167



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCL23 11295
ANXA1 11014
FPR2 10947
FPR3 10705
FPR1 10642
SAA1 1892
HEBP1 -456
APP -3499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCL23 11295
ANXA1 11014
FPR2 10947
FPR3 10705
FPR1 10642
SAA1 1892
HEBP1 -456
APP -3499


CYP2E1 reactions

CYP2E1 reactions
219
set CYP2E1 reactions
setSize 11
pANOVA 0.0022
s.dist 0.533
p.adjustANOVA 0.0974



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP2A7 11465
CYP2C8 11395
CYP2A13 11292
CYP2F1 10756
CYP2B6 10584
CYP2C19 10176
CYP2D6 7364
CYP2A6 2709
CYP2E1 2280
CYP2S1 -3035
CYP2C9 -3558

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP2A7 11465
CYP2C8 11395
CYP2A13 11292
CYP2F1 10756
CYP2B6 10584
CYP2C19 10176
CYP2D6 7364
CYP2A6 2709
CYP2E1 2280
CYP2S1 -3035
CYP2C9 -3558


EGFR interacts with phospholipase C-gamma

EGFR interacts with phospholipase C-gamma
479
set EGFR interacts with phospholipase C-gamma
setSize 9
pANOVA 0.0064
s.dist -0.525
p.adjustANOVA 0.15



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPGN -10955
AREG -10924
EREG -9691
PLCG1 -6901
BTC -6076
EGFR -3464
EGF -3037
HBEGF -1421
TGFA 1329

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPGN -10955
AREG -10924
EREG -9691
PLCG1 -6901
BTC -6076
EGFR -3464
EGF -3037
HBEGF -1421
TGFA 1329


Mucopolysaccharidoses

Mucopolysaccharidoses
1001
set Mucopolysaccharidoses
setSize 11
pANOVA 0.00269
s.dist -0.523
p.adjustANOVA 0.0974



Top enriched genes

Top 20 genes
GeneID Gene Rank
HYAL1 -10554
GALNS -8972
SGSH -7645
IDUA -7489
NAGLU -7202
GUSB -7065
HGSNAT -5255
GLB1 -5137
ARSB -4376
IDS -842
GNS 2320

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HYAL1 -10554
GALNS -8972
SGSH -7645
IDUA -7489
NAGLU -7202
GUSB -7065
HGSNAT -5255
GLB1 -5137
ARSB -4376
IDS -842
GNS 2320


Pre-NOTCH Processing in the Endoplasmic Reticulum

Pre-NOTCH Processing in the Endoplasmic Reticulum
1245
set Pre-NOTCH Processing in the Endoplasmic Reticulum
setSize 6
pANOVA 0.0271
s.dist -0.521
p.adjustANOVA 0.29



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH3 -8566
NOTCH1 -6878
POGLUT1 -5905
NOTCH2 -4991
POFUT1 -3971
NOTCH4 -3533

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH3 -8566
NOTCH1 -6878
POGLUT1 -5905
NOTCH2 -4991
POFUT1 -3971
NOTCH4 -3533


Transport of fatty acids

Transport of fatty acids
1898
set Transport of fatty acids
setSize 8
pANOVA 0.0116
s.dist -0.515
p.adjustANOVA 0.199



Top enriched genes

Top 20 genes
GeneID Gene Rank
LCN12 -10907
LCN15 -10389
SLC27A6 -9987
SLC27A1 -9293
SLC27A4 -6419
LCN1 -4541
LCN9 -2875
APOD 9813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LCN12 -10907
LCN15 -10389
SLC27A6 -9987
SLC27A1 -9293
SLC27A4 -6419
LCN1 -4541
LCN9 -2875
APOD 9813


Inhibition of Signaling by Overexpressed EGFR

Inhibition of Signaling by Overexpressed EGFR
786
set Inhibition of Signaling by Overexpressed EGFR
setSize 8
pANOVA 0.0122
s.dist -0.512
p.adjustANOVA 0.206



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPGN -10955
AREG -10924
EREG -9691
BTC -6076
EGFR -3464
EGF -3037
HBEGF -1421
TGFA 1329

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPGN -10955
AREG -10924
EREG -9691
BTC -6076
EGFR -3464
EGF -3037
HBEGF -1421
TGFA 1329


Signaling by Overexpressed Wild-Type EGFR in Cancer

Signaling by Overexpressed Wild-Type EGFR in Cancer
1668
set Signaling by Overexpressed Wild-Type EGFR in Cancer
setSize 8
pANOVA 0.0122
s.dist -0.512
p.adjustANOVA 0.206



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPGN -10955
AREG -10924
EREG -9691
BTC -6076
EGFR -3464
EGF -3037
HBEGF -1421
TGFA 1329

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPGN -10955
AREG -10924
EREG -9691
BTC -6076
EGFR -3464
EGF -3037
HBEGF -1421
TGFA 1329


Conjugation of benzoate with glycine

Conjugation of benzoate with glycine
306
set Conjugation of benzoate with glycine
setSize 6
pANOVA 0.0327
s.dist 0.503
p.adjustANOVA 0.318



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSM2B 11530
ACSM1 11167
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSM2B 11530
ACSM1 11167
GLYAT 9490
GLYATL2 6889
GLYATL3 -223
GLYATL1 -1926


Sulfide oxidation to sulfate

Sulfide oxidation to sulfate
1719
set Sulfide oxidation to sulfate
setSize 5
pANOVA 0.0514
s.dist -0.503
p.adjustANOVA 0.379



Top enriched genes

Top 20 genes
GeneID Gene Rank
TSTD1 -10692
SLC25A10 -10257
TST -8492
SUOX -2745
ETHE1 5027

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TSTD1 -10692
SLC25A10 -10257
TST -8492
SUOX -2745
ETHE1 5027


Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
528
set Expression and translocation of olfactory receptors
setSize 334
pANOVA 1.38e-55
s.dist 0.498
p.adjustANOVA 2.78e-52



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR56B1 11868
OR7D2 11861
OR52M1 11855
OR6Q1 11852
OR1J4 11847
OR1L1 11843
OR6C75 11837
OR51B4 11836
OR5B21 11833
OR51V1 11821
OR5H6 11811
OR10S1 11808
OR4A47 11806
OR1S1 11804
OR4B1 11803
OR2A25 11802
OR5K4 11798
OR52B2 11797
OR4D2 11787
OR6C70 11784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR56B1 11868.0
OR7D2 11861.0
OR52M1 11855.0
OR6Q1 11852.0
OR1J4 11847.0
OR1L1 11843.0
OR6C75 11837.0
OR51B4 11836.0
OR5B21 11833.0
OR51V1 11821.0
OR5H6 11811.0
OR10S1 11808.0
OR4A47 11806.0
OR1S1 11804.0
OR4B1 11803.0
OR2A25 11802.0
OR5K4 11798.0
OR52B2 11797.0
OR4D2 11787.0
OR6C70 11784.0
OR1J2 11765.0
OR1Q1 11751.0
OR56A3 11738.0
OR51L1 11734.0
OR52N2 11725.0
OR1B1 11723.0
OR51B2 11722.0
OR1I1 11714.0
OR52N1 11706.0
OR4K15 11690.0
OR52D1 11689.0
OR52A1 11686.0
OR10H1 11685.0
OR2F2 11665.0
OR4D11 11659.0
OR10A7 11654.0
OR5B12 11650.0
OR10H3 11649.0
OR4E2 11641.0
OR8B12 11638.0
OR4D1 11615.0
OR9A2 11612.0
OR4C6 11611.0
OR5K2 11605.0
OR5M10 11596.0
OR4N4 11573.0
OR2J2 11572.0
OR2A5 11552.0
OR5K3 11549.0
OR52A5 11546.0
OR1L4 11534.0
OR5D13 11525.0
OR6C6 11516.0
OR2F1 11514.0
OR8H3 11512.0
OR1L3 11510.0
OR6S1 11495.0
OR10H4 11490.0
OR6C4 11485.0
OR51I1 11474.0
OR9K2 11472.0
OR4A16 11470.0
OR4S2 11469.0
OR4X2 11466.0
OR52E6 11455.0
OR5B2 11447.0
OR56A5 11438.0
OR4S1 11422.0
OR1M1 11417.0
OR4X1 11414.0
OR4C16 11402.0
OR4D6 11400.0
OR9A4 11399.0
OR10A6 11392.0
OR6T1 11369.0
OR52H1 11353.0
OR2D2 11352.0
OR4M2 11340.0
OR4C13 11338.0
OR7G2 11331.0
OR5L1 11329.0
OR51F1 11328.0
OR5AU1 11318.0
OR13C4 11302.0
OR1N2 11285.0
OR8D1 11270.0
OR4K14 11268.0
OR5M3 11259.0
OR52N5 11258.0
OR10A3 11252.0
OR6X1 11247.0
OR6M1 11238.0
OR5A2 11230.0
OR51M1 11215.0
OR10G2 11198.0
OR51B5 11197.0
OR5F1 11179.0
OR5V1 11173.0
OR5B17 11145.0
OR51G1 11127.0
OR6P1 11123.0
OR51G2 11095.0
OR4K13 11040.0
OR12D2 11039.0
OR5H2 11036.0
OR6B1 11021.0
OR10H2 11010.0
OR4K2 10994.0
OR10X1 10983.0
OR10G9 10980.0
OR51Q1 10969.0
OR10W1 10934.0
OR5P3 10926.0
OR6C2 10923.0
OR52E8 10918.0
OR5H1 10908.0
OR10H5 10880.0
OR5A1 10867.0
OR4C3 10850.0
OR2C1 10843.0
OR56A1 10831.0
OR7G1 10820.0
OR9Q2 10808.0
OR52R1 10803.0
OR7G3 10801.0
OR10A5 10784.0
OR1N1 10764.0
OR1G1 10763.0
OR2H1 10743.0
OR52K2 10724.0
OR2AP1 10711.0
OR11H4 10707.0
OR5I1 10706.0
OR10A4 10683.0
OR51T1 10668.0
OR52I2 10666.0
OR9Q1 10662.0
OR5D18 10613.0
OR4C46 10611.0
OR5AC2 10601.0
OR5AS1 10588.0
OR5M11 10581.0
OR6A2 10529.0
OR51E1 10527.0
OR4F15 10526.0
OR5D16 10485.0
OR12D3 10482.0
OR13C3 10453.0
OR56A4 10450.0
OR9G4 10368.0
OR10AD1 10357.0
OR10J3 10353.0
OR1E1 10339.0
OR2W1 10331.0
OR4K1 10295.0
OR52J3 10285.0
OR5AK2 10251.0
OR4A15 10179.0
OR52I1 10169.0
OR51F2 10154.0
OR4M1 10143.0
OR5J2 10142.0
OR3A3 10091.0
OR6K6 10071.0
OR2AG2 10008.0
OR9G1 9980.5
OR9G9 9980.5
OR10G7 9958.0
OR5B3 9928.0
RTP1 9911.0
OR4K17 9900.0
OR6V1 9876.0
OR6N1 9702.0
OR8K1 9651.0
OR51E2 9621.0
OR13A1 9484.0
OR10G4 9445.0
OR8K3 9409.0
OR6Y1 9399.0
OR10P1 9325.0
OR2B3 9273.0
OR6B2 9256.0
OR4K5 9239.0
OR56B4 9230.0
OR2B2 9139.0
OR8A1 9124.0
OR8D4 9013.0
OR51S1 8986.0
OR7D4 8917.0
OR14J1 8806.0
OR10C1 8804.0
OR6C74 8717.0
OR4D9 8636.0
OR10J1 8593.0
OR6C65 8592.0
RTP2 8588.0
OR7A17 8492.0
OR51B6 8418.0
OR6C3 8262.0
OR51D1 8235.0
OR4D5 8095.0
OR8U8 8007.0
OR6B3 7939.0
OR1A1 7809.0
OR5AP2 7773.0
OR2D3 7756.0
OR2Z1 7613.0
OR7A5 7551.0
OR1L8 7513.0
OR10J5 7468.0
OR10Q1 7334.0
OR7C2 7174.0
OR10K2 7140.0
OR8H1 7084.0
OR52B6 7075.0
OR51I2 6931.0
OR4N2 6601.0
OR2AT4 6409.0
OR8S1 6266.0
OR5P2 6133.0
OR4N5 6049.0
OR10AG1 5969.0
OR10G3 5882.0
OR2A12 5755.0
OR6K3 5670.0
OR52L1 5651.0
OR13C9 5579.0
OR10Z1 5438.0
OR10G8 5385.0
OR6K2 5328.0
OR9I1 5183.0
OR2AG1 4991.0
OR14I1 4818.0
OR13F1 4678.0
OR11A1 4605.0
OR52E2 4414.0
OR10V1 4330.0
OR2A2 4055.0
OR10T2 3691.0
OR52K1 3508.0
OR8U1 3487.0
OR52A4P 3458.0
OR1E2 3427.0
OR11G2 3418.0
OR4C12 3240.0
OR8G5 2878.0
OR8H2 2776.0
OR1D2 2630.0
OR8B8 2529.0
OR2T11 2083.0
EBF1 1813.0
OR5C1 1808.0
OR1S2 1505.0
OR5W2 1352.0
OR1F1 1307.0
OR2Y1 1186.0
OR13H1 933.0
OR2AK2 739.0
OR3A1 620.0
OR5M8 558.0
OR2T1 378.0
OR2K2 238.0
REEP1 43.0
OR8I2 22.0
OR4D10 12.0
OR11H6 -117.0
OR6C1 -188.0
OR6N2 -325.0
OR1K1 -362.0
OR2T34 -421.0
OR14C36 -862.0
LHX2 -973.0
LDB1 -1210.0
OR7A10 -1468.0
OR51A2 -1578.0
OR4L1 -1581.0
OR4C15 -1607.0
OR1A2 -2413.0
OR2B6 -2617.0
OR8B4 -2660.0
OR8G1 -3327.0
OR8U3 -3468.0
OR2M5 -3757.0
OR51A7 -4079.0
OR2T10 -4152.0
OR2L2 -4307.0
OR2M2 -4478.0
OR14A16 -4532.0
OR2W3 -4552.0
OR6C68 -4579.0
OR5L2 -4826.0
OR2G3 -5512.0
OR2V2 -5566.0
OR2S2 -5815.0
OR11L1 -6130.0
OR5D14 -6433.0
OR7C1 -6886.0
OR2L13 -6909.0
OR2T8 -6989.0
OR3A2 -7170.0
OR2G6 -7286.0
OR2B11 -7544.0
OR8D2 -7687.0
OR2G2 -7760.0
OR5AR1 -8061.0
OR8K5 -8139.0
OR4A5 -8487.0
OR52W1 -8905.0
OR1L6 -8970.0
OR2T6 -8985.0
OR2V1 -9033.0
OR2M4 -9065.0
OR1J1 -9068.0
OR2H2 -9272.0
OR2T3 -9750.0
OR7E24 -9843.0
OR2T33 -9879.0
OR4F6 -10019.0
OR10A2 -10079.0
OR2AE1 -10087.0
OR13G1 -10214.0
OR2M3 -10227.0
OR6F1 -10268.0
OR8B2 -10420.0
OR5T3 -10562.0
OR10K1 -10572.0
OR2C3 -10574.0
OR1C1 -10594.0
OR2A14 -10615.0
OR2L8 -10743.0
OR2T27 -10746.0
OR13J1 -10833.0
OR2L3 -10892.0
OR2T4 -10973.0


Nef Mediated CD4 Down-regulation

Nef Mediated CD4 Down-regulation
1055
set Nef Mediated CD4 Down-regulation
setSize 9
pANOVA 0.011
s.dist -0.49
p.adjustANOVA 0.195



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2A2 -10138
CD4 -8591
AP2M1 -7849
LCK -7785
AP2A1 -6828
AP2S1 -5603
ARF1 -3650
AP2B1 -672
ATP6V1H 3615

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2A2 -10138
CD4 -8591
AP2M1 -7849
LCK -7785
AP2A1 -6828
AP2S1 -5603
ARF1 -3650
AP2B1 -672
ATP6V1H 3615


Olfactory Signaling Pathway

Olfactory Signaling Pathway
1124
set Olfactory Signaling Pathway
setSize 342
pANOVA 4.61e-54
s.dist 0.486
p.adjustANOVA 4.64e-51



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR56B1 11868
OR7D2 11861
OR52M1 11855
OR6Q1 11852
OR1J4 11847
OR1L1 11843
OR6C75 11837
OR51B4 11836
OR5B21 11833
OR51V1 11821
OR5H6 11811
OR10S1 11808
OR4A47 11806
OR1S1 11804
OR4B1 11803
OR2A25 11802
OR5K4 11798
OR52B2 11797
OR4D2 11787
OR6C70 11784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR56B1 11868.0
OR7D2 11861.0
OR52M1 11855.0
OR6Q1 11852.0
OR1J4 11847.0
OR1L1 11843.0
OR6C75 11837.0
OR51B4 11836.0
OR5B21 11833.0
OR51V1 11821.0
OR5H6 11811.0
OR10S1 11808.0
OR4A47 11806.0
OR1S1 11804.0
OR4B1 11803.0
OR2A25 11802.0
OR5K4 11798.0
OR52B2 11797.0
OR4D2 11787.0
OR6C70 11784.0
OR1J2 11765.0
OR1Q1 11751.0
OR56A3 11738.0
OR51L1 11734.0
OR52N2 11725.0
OR1B1 11723.0
OR51B2 11722.0
OR1I1 11714.0
OR52N1 11706.0
OR4K15 11690.0
OR52D1 11689.0
OR52A1 11686.0
OR10H1 11685.0
OR2F2 11665.0
OR4D11 11659.0
OR10A7 11654.0
OR5B12 11650.0
OR10H3 11649.0
OR4E2 11641.0
OR8B12 11638.0
OR4D1 11615.0
OR9A2 11612.0
OR4C6 11611.0
OR5K2 11605.0
OR5M10 11596.0
OR4N4 11573.0
OR2J2 11572.0
OR2A5 11552.0
OR5K3 11549.0
OR52A5 11546.0
OR1L4 11534.0
OR5D13 11525.0
OR6C6 11516.0
OR2F1 11514.0
OR8H3 11512.0
OR1L3 11510.0
OR6S1 11495.0
OR10H4 11490.0
OR6C4 11485.0
OR51I1 11474.0
OR9K2 11472.0
OR4A16 11470.0
OR4S2 11469.0
OR4X2 11466.0
OR52E6 11455.0
OR5B2 11447.0
OR56A5 11438.0
OR4S1 11422.0
OR1M1 11417.0
OR4X1 11414.0
OR4C16 11402.0
OR4D6 11400.0
OR9A4 11399.0
OR10A6 11392.0
OR6T1 11369.0
OR52H1 11353.0
OR2D2 11352.0
OR4M2 11340.0
OR4C13 11338.0
OR7G2 11331.0
OR5L1 11329.0
OR51F1 11328.0
OR5AU1 11318.0
OR13C4 11302.0
OR1N2 11285.0
OR8D1 11270.0
OR4K14 11268.0
OR5M3 11259.0
OR52N5 11258.0
OR10A3 11252.0
OR6X1 11247.0
OR6M1 11238.0
OR5A2 11230.0
OR51M1 11215.0
OR10G2 11198.0
OR51B5 11197.0
OR5F1 11179.0
OR5V1 11173.0
OR5B17 11145.0
OR51G1 11127.0
OR6P1 11123.0
OR51G2 11095.0
OR4K13 11040.0
OR12D2 11039.0
OR5H2 11036.0
OR6B1 11021.0
OR10H2 11010.0
OR4K2 10994.0
OR10X1 10983.0
OR10G9 10980.0
OR51Q1 10969.0
OR10W1 10934.0
OR5P3 10926.0
OR6C2 10923.0
OR52E8 10918.0
OR5H1 10908.0
OR10H5 10880.0
OR5A1 10867.0
OR4C3 10850.0
OR2C1 10843.0
OR56A1 10831.0
OR7G1 10820.0
OR9Q2 10808.0
OR52R1 10803.0
OR7G3 10801.0
OR10A5 10784.0
OR1N1 10764.0
OR1G1 10763.0
OR2H1 10743.0
OR52K2 10724.0
OR2AP1 10711.0
OR11H4 10707.0
OR5I1 10706.0
OR10A4 10683.0
OR51T1 10668.0
OR52I2 10666.0
OR9Q1 10662.0
OR5D18 10613.0
OR4C46 10611.0
OR5AC2 10601.0
OR5AS1 10588.0
OR5M11 10581.0
OR6A2 10529.0
OR51E1 10527.0
OR4F15 10526.0
OR5D16 10485.0
OR12D3 10482.0
OR13C3 10453.0
OR56A4 10450.0
OR9G4 10368.0
OR10AD1 10357.0
OR10J3 10353.0
OR1E1 10339.0
OR2W1 10331.0
OR4K1 10295.0
OR52J3 10285.0
OR5AK2 10251.0
OR4A15 10179.0
OR52I1 10169.0
OR51F2 10154.0
OR4M1 10143.0
OR5J2 10142.0
OR3A3 10091.0
OR6K6 10071.0
OR2AG2 10008.0
OR9G1 9980.5
OR9G9 9980.5
OR10G7 9958.0
OR5B3 9928.0
RTP1 9911.0
OR4K17 9900.0
OR6V1 9876.0
OR6N1 9702.0
OR8K1 9651.0
OR51E2 9621.0
OR13A1 9484.0
OR10G4 9445.0
OR8K3 9409.0
OR6Y1 9399.0
OR10P1 9325.0
OR2B3 9273.0
CNGA4 9259.0
OR6B2 9256.0
OR4K5 9239.0
OR56B4 9230.0
OR2B2 9139.0
OR8A1 9124.0
OR8D4 9013.0
OR51S1 8986.0
OR7D4 8917.0
OR14J1 8806.0
OR10C1 8804.0
OR6C74 8717.0
OR4D9 8636.0
OR10J1 8593.0
OR6C65 8592.0
RTP2 8588.0
OR7A17 8492.0
OR51B6 8418.0
OR6C3 8262.0
OR51D1 8235.0
OR4D5 8095.0
OR8U8 8007.0
OR6B3 7939.0
OR1A1 7809.0
OR5AP2 7773.0
OR2D3 7756.0
OR2Z1 7613.0
OR7A5 7551.0
OR1L8 7513.0
OR10J5 7468.0
ANO2 7351.0
OR10Q1 7334.0
OR7C2 7174.0
OR10K2 7140.0
OR8H1 7084.0
OR52B6 7075.0
OR51I2 6931.0
GNG13 6603.0
OR4N2 6601.0
OR2AT4 6409.0
OR8S1 6266.0
OR5P2 6133.0
OR4N5 6049.0
OR10AG1 5969.0
OR10G3 5882.0
OR2A12 5755.0
OR6K3 5670.0
OR52L1 5651.0
OR13C9 5579.0
OR10Z1 5438.0
OR10G8 5385.0
OR6K2 5328.0
OR9I1 5183.0
OR2AG1 4991.0
OR14I1 4818.0
OR13F1 4678.0
OR11A1 4605.0
OR52E2 4414.0
OR10V1 4330.0
OR2A2 4055.0
OR10T2 3691.0
OR52K1 3508.0
OR8U1 3487.0
OR52A4P 3458.0
OR1E2 3427.0
OR11G2 3418.0
OR4C12 3240.0
OR8G5 2878.0
OR8H2 2776.0
OR1D2 2630.0
OR8B8 2529.0
OR2T11 2083.0
EBF1 1813.0
OR5C1 1808.0
OR1S2 1505.0
OR5W2 1352.0
OR1F1 1307.0
OR2Y1 1186.0
CNGA2 1023.0
OR13H1 933.0
OR2AK2 739.0
OR3A1 620.0
OR5M8 558.0
OR2T1 378.0
OR2K2 238.0
REEP1 43.0
OR8I2 22.0
OR4D10 12.0
OR11H6 -117.0
OR6C1 -188.0
OR6N2 -325.0
OR1K1 -362.0
OR2T34 -421.0
OR14C36 -862.0
LHX2 -973.0
LDB1 -1210.0
OR7A10 -1468.0
OR51A2 -1578.0
OR4L1 -1581.0
OR4C15 -1607.0
OR1A2 -2413.0
OR2B6 -2617.0
OR8B4 -2660.0
OR8G1 -3327.0
OR8U3 -3468.0
OR2M5 -3757.0
CNGB1 -3831.0
OR51A7 -4079.0
OR2T10 -4152.0
OR2L2 -4307.0
OR2M2 -4478.0
OR14A16 -4532.0
OR2W3 -4552.0
OR6C68 -4579.0
GNAL -4709.0
OR5L2 -4826.0
OR2G3 -5512.0
OR2V2 -5566.0
OR2S2 -5815.0
OR11L1 -6130.0
OR5D14 -6433.0
OR7C1 -6886.0
OR2L13 -6909.0
OR2T8 -6989.0
OR3A2 -7170.0
OR2G6 -7286.0
OR2B11 -7544.0
OR8D2 -7687.0
OR2G2 -7760.0
OR5AR1 -8061.0
OR8K5 -8139.0
OR4A5 -8487.0
ADCY3 -8634.0
OR52W1 -8905.0
OR1L6 -8970.0
OR2T6 -8985.0
OR2V1 -9033.0
OR2M4 -9065.0
OR1J1 -9068.0
GNB1 -9151.0
OR2H2 -9272.0
OR2T3 -9750.0
OR7E24 -9843.0
OR2T33 -9879.0
OR4F6 -10019.0
OR10A2 -10079.0
OR2AE1 -10087.0
OR13G1 -10214.0
OR2M3 -10227.0
OR6F1 -10268.0
OR8B2 -10420.0
OR5T3 -10562.0
OR10K1 -10572.0
OR2C3 -10574.0
OR1C1 -10594.0
OR2A14 -10615.0
OR2L8 -10743.0
OR2T27 -10746.0
OR13J1 -10833.0
OR2L3 -10892.0
OR2T4 -10973.0


Reelin signalling pathway

Reelin signalling pathway
1402
set Reelin signalling pathway
setSize 5
pANOVA 0.0608
s.dist 0.484
p.adjustANOVA 0.391



Top enriched genes

Top 20 genes
GeneID Gene Rank
RELN 9541
DAB1 8124
VLDLR 7176
SH3KBP1 4708
FYN 112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELN 9541
DAB1 8124
VLDLR 7176
SH3KBP1 4708
FYN 112


Biosynthesis of maresin-like SPMs

Biosynthesis of maresin-like SPMs
177
set Biosynthesis of maresin-like SPMs
setSize 6
pANOVA 0.0423
s.dist 0.479
p.adjustANOVA 0.361



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP2C8 11395
CYP3A4 9179
CYP1A2 8556
CYP2D6 7364
CYP2E1 2280
CYP2C9 -3558

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP2C8 11395
CYP3A4 9179
CYP1A2 8556
CYP2D6 7364
CYP2E1 2280
CYP2C9 -3558


Beta defensins

Beta defensins
159
set Beta defensins
setSize 27
pANOVA 2.03e-05
s.dist 0.474
p.adjustANOVA 0.00488



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCR2 11662.0
DEFB133 11599.0
DEFB113 11464.0
DEFB116 11371.0
DEFB119 11287.0
DEFB118 11237.0
DEFB114 11213.0
DEFB103A 11037.5
DEFB121 10678.0
TLR1 10582.0
DEFB135 10406.0
DEFB136 10072.0
DEFB124 9944.0
DEFB123 7664.0
CCR6 6450.0
DEFB115 6231.0
DEFB125 5903.0
DEFB126 4995.0
DEFB128 2190.0
DEFB127 1288.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCR2 11662.0
DEFB133 11599.0
DEFB113 11464.0
DEFB116 11371.0
DEFB119 11287.0
DEFB118 11237.0
DEFB114 11213.0
DEFB103A 11037.5
DEFB121 10678.0
TLR1 10582.0
DEFB135 10406.0
DEFB136 10072.0
DEFB124 9944.0
DEFB123 7664.0
CCR6 6450.0
DEFB115 6231.0
DEFB125 5903.0
DEFB126 4995.0
DEFB128 2190.0
DEFB127 1288.0
DEFB108B 239.0
DEFB132 -276.0
DEFB129 -1733.0
DEFB104A -3835.5
DEFB1 -4158.0
TLR2 -5282.0
DEFB134 -5459.0


E2F-enabled inhibition of pre-replication complex formation

E2F-enabled inhibition of pre-replication complex formation
474
set E2F-enabled inhibition of pre-replication complex formation
setSize 9
pANOVA 0.0144
s.dist 0.471
p.adjustANOVA 0.222



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 9482
ORC4 9117
CCNB1 8805
MCM8 7131
ORC6 7057
ORC3 6686
CDK1 2115
ORC5 1579
ORC2 56

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 9482
ORC4 9117
CCNB1 8805
MCM8 7131
ORC6 7057
ORC3 6686
CDK1 2115
ORC5 1579
ORC2 56


OAS antiviral response

OAS antiviral response
1123
set OAS antiviral response
setSize 9
pANOVA 0.0149
s.dist -0.469
p.adjustANOVA 0.223



Top enriched genes

Top 20 genes
GeneID Gene Rank
FLNA -9886
OASL -8373
OAS1 -8225
PDE12 -5925
OAS3 -5485
RNASEL -5098
OAS2 -3339
RIGI -2335
ABCE1 3319

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FLNA -9886
OASL -8373
OAS1 -8225
PDE12 -5925
OAS3 -5485
RNASEL -5098
OAS2 -3339
RIGI -2335
ABCE1 3319


Defective LFNG causes SCDO3

Defective LFNG causes SCDO3
388
set Defective LFNG causes SCDO3
setSize 5
pANOVA 0.0727
s.dist -0.463
p.adjustANOVA 0.425



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH3 -8566
NOTCH1 -6878
NOTCH2 -4991
NOTCH4 -3533
LFNG -913

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH3 -8566
NOTCH1 -6878
NOTCH2 -4991
NOTCH4 -3533
LFNG -913


NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose

NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
1043
set NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
setSize 5
pANOVA 0.0732
s.dist -0.463
p.adjustANOVA 0.425



Top enriched genes

Top 20 genes
GeneID Gene Rank
RXRA -8542
PLIN1 -8440
NR1H3 -7376
RXRB -4473
NR1H2 3993

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RXRA -8542
PLIN1 -8440
NR1H3 -7376
RXRB -4473
NR1H2 3993


GRB7 events in ERBB2 signaling

GRB7 events in ERBB2 signaling
654
set GRB7 events in ERBB2 signaling
setSize 5
pANOVA 0.0747
s.dist -0.46
p.adjustANOVA 0.428



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB7 -10645
ERBB2 -10029
NRG2 -6779
ERBB3 -4313
NRG1 7066

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB7 -10645
ERBB2 -10029
NRG2 -6779
ERBB3 -4313
NRG1 7066


Regulation of CDH19 Expression and Function

Regulation of CDH19 Expression and Function
1413
set Regulation of CDH19 Expression and Function
setSize 7
pANOVA 0.0352
s.dist -0.46
p.adjustANOVA 0.327



Top enriched genes

Top 20 genes
GeneID Gene Rank
SOX10 -10919
CTNND1 -10434
JUP -10168
ZC3H12A -6832
CTNNA1 -4601
CTNNB1 -333
CDH19 8758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SOX10 -10919
CTNND1 -10434
JUP -10168
ZC3H12A -6832
CTNNA1 -4601
CTNNB1 -333
CDH19 8758


Sema4D mediated inhibition of cell attachment and migration

Sema4D mediated inhibition of cell attachment and migration
1581
set Sema4D mediated inhibition of cell attachment and migration
setSize 8
pANOVA 0.0256
s.dist -0.456
p.adjustANOVA 0.283



Top enriched genes

Top 20 genes
GeneID Gene Rank
PLXNB1 -10414
RND1 -8867
ARHGAP35 -8321
RAC1 -6548
RHOA -4849
SEMA4D -4394
RRAS -2815
MET 7112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLXNB1 -10414
RND1 -8867
ARHGAP35 -8321
RAC1 -6548
RHOA -4849
SEMA4D -4394
RRAS -2815
MET 7112


NFE2L2 regulating tumorigenic genes

NFE2L2 regulating tumorigenic genes
1027
set NFE2L2 regulating tumorigenic genes
setSize 11
pANOVA 0.00918
s.dist -0.454
p.adjustANOVA 0.181



Top enriched genes

Top 20 genes
GeneID Gene Rank
AREG -10924
PDGFA -8837
CREBBP -8768
BCL2L1 -7957
NOTCH1 -6878
SP1 -4222
BCL2 -4180
EGF -3037
MAFK -1852
EP300 1142
NFE2L2 2024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AREG -10924
PDGFA -8837
CREBBP -8768
BCL2L1 -7957
NOTCH1 -6878
SP1 -4222
BCL2 -4180
EGF -3037
MAFK -1852
EP300 1142
NFE2L2 2024


Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
1460
set Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
setSize 5
pANOVA 0.0799
s.dist 0.452
p.adjustANOVA 0.44



Top enriched genes

Top 20 genes
GeneID Gene Rank
NKX2-2 8967
NEUROG3 8818
PAX4 8018
INSM1 2173
NEUROD1 -151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NKX2-2 8967
NEUROG3 8818
PAX4 8018
INSM1 2173
NEUROD1 -151


Miscellaneous substrates

Miscellaneous substrates
971
set Miscellaneous substrates
setSize 12
pANOVA 0.00746
s.dist 0.446
p.adjustANOVA 0.165



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP4F2 11778
CYP4B1 11439
CYP4F3 10723
CYP4F22 10494
CYP4F11 10463
CYP4A11 8201
CYP2D6 7364
CYP3A43 4152
CYP2U1 3356
CYP4A22 1397
CYP2S1 -3035
CYP2W1 -10428

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP4F2 11778
CYP4B1 11439
CYP4F3 10723
CYP4F22 10494
CYP4F11 10463
CYP4A11 8201
CYP2D6 7364
CYP3A43 4152
CYP2U1 3356
CYP4A22 1397
CYP2S1 -3035
CYP2W1 -10428


CDC6 association with the ORC:origin complex

CDC6 association with the ORC:origin complex
196
set CDC6 association with the ORC:origin complex
setSize 8
pANOVA 0.0295
s.dist 0.444
p.adjustANOVA 0.297



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC1 9482
ORC4 9117
MCM8 7131
ORC6 7057
ORC3 6686
CDC6 2693
ORC5 1579
ORC2 56

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC1 9482
ORC4 9117
MCM8 7131
ORC6 7057
ORC3 6686
CDC6 2693
ORC5 1579
ORC2 56


Defensins

Defensins
405
set Defensins
setSize 35
pANOVA 5.74e-06
s.dist 0.443
p.adjustANOVA 0.00193



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCR2 11662.0
DEFB133 11599.0
DEFB113 11464.0
DEFB116 11371.0
DEFB119 11287.0
DEFB118 11237.0
DEFB114 11213.0
DEFA4 11146.0
DEFB103A 11037.5
DEFA5 10992.0
DEFA1 10974.0
DEFA3 10974.0
DEFB121 10678.0
TLR1 10582.0
DEFB135 10406.0
DEFA6 10402.0
DEFB136 10072.0
DEFB124 9944.0
DEFB123 7664.0
CCR6 6450.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCR2 11662.0
DEFB133 11599.0
DEFB113 11464.0
DEFB116 11371.0
DEFB119 11287.0
DEFB118 11237.0
DEFB114 11213.0
DEFA4 11146.0
DEFB103A 11037.5
DEFA5 10992.0
DEFA1 10974.0
DEFA3 10974.0
DEFB121 10678.0
TLR1 10582.0
DEFB135 10406.0
DEFA6 10402.0
DEFB136 10072.0
DEFB124 9944.0
DEFB123 7664.0
CCR6 6450.0
DEFB115 6231.0
DEFB125 5903.0
DEFB126 4995.0
DEFB128 2190.0
DEFB127 1288.0
DEFB108B 239.0
DEFB132 -276.0
DEFB129 -1733.0
DEFB104A -3835.5
PRSS3 -3921.0
DEFB1 -4158.0
TLR2 -5282.0
DEFB134 -5459.0
ART1 -7974.0
CD4 -8591.0


Uptake and function of diphtheria toxin

Uptake and function of diphtheria toxin
1927
set Uptake and function of diphtheria toxin
setSize 6
pANOVA 0.065
s.dist -0.435
p.adjustANOVA 0.402



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD9 -9992
EEF2 -9454
HSP90AB1 -6678
TXNRD1 -2247
HBEGF -1421
HSP90AA1 1893

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD9 -9992
EEF2 -9454
HSP90AB1 -6678
TXNRD1 -2247
HBEGF -1421
HSP90AA1 1893


Ciprofloxacin ADME

Ciprofloxacin ADME
280
set Ciprofloxacin ADME
setSize 5
pANOVA 0.092
s.dist 0.435
p.adjustANOVA 0.463



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALB 10551
SLCO1A2 10467
SLC22A8 6063
ABCG2 5581
SLC22A1 -5827

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALB 10551
SLCO1A2 10467
SLC22A8 6063
ABCG2 5581
SLC22A1 -5827


GAB1 signalosome

GAB1 signalosome
639
set GAB1 signalosome
setSize 17
pANOVA 0.00191
s.dist -0.435
p.adjustANOVA 0.0951



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPGN -10955
AREG -10924
PIK3R1 -10856
CSK -10256
SRC -9773
EREG -9691
PXN -8910
BTC -6076
EGFR -3464
EGF -3037
GRB2 -2663
HBEGF -1421
TGFA 1329
PIK3CA 1513
PTPN11 1886
GAB1 1931
PAG1 2413

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPGN -10955
AREG -10924
PIK3R1 -10856
CSK -10256
SRC -9773
EREG -9691
PXN -8910
BTC -6076
EGFR -3464
EGF -3037
GRB2 -2663
HBEGF -1421
TGFA 1329
PIK3CA 1513
PTPN11 1886
GAB1 1931
PAG1 2413


Synthesis of Ketone Bodies

Synthesis of Ketone Bodies
1737
set Synthesis of Ketone Bodies
setSize 8
pANOVA 0.0347
s.dist -0.431
p.adjustANOVA 0.326



Top enriched genes

Top 20 genes
GeneID Gene Rank
HMGCS2 -9396
HMGCL -7839
AACS -7611
BDH1 -4744
HMGCLL1 -2867
BDH2 -2829
ACAT1 -1028
ACSS3 -533

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HMGCS2 -9396
HMGCL -7839
AACS -7611
BDH1 -4744
HMGCLL1 -2867
BDH2 -2829
ACAT1 -1028
ACSS3 -533


Arachidonate production from DAG

Arachidonate production from DAG
127
set Arachidonate production from DAG
setSize 5
pANOVA 0.095
s.dist -0.431
p.adjustANOVA 0.469



Top enriched genes

Top 20 genes
GeneID Gene Rank
DAGLA -9279
ABHD12 -6643
MGLL -3948
DAGLB -1920
ABHD6 -1237

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DAGLA -9279
ABHD12 -6643
MGLL -3948
DAGLB -1920
ABHD6 -1237


Nef Mediated CD8 Down-regulation

Nef Mediated CD8 Down-regulation
1056
set Nef Mediated CD8 Down-regulation
setSize 7
pANOVA 0.0512
s.dist -0.426
p.adjustANOVA 0.379



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2A2 -10138
AP2M1 -7849
AP2A1 -6828
AP2S1 -5603
CD8B -4309
AP2B1 -672
ATP6V1H 3615

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2A2 -10138
AP2M1 -7849
AP2A1 -6828
AP2S1 -5603
CD8B -4309
AP2B1 -672
ATP6V1H 3615


Specification of the neural plate border

Specification of the neural plate border
1710
set Specification of the neural plate border
setSize 16
pANOVA 0.00343
s.dist 0.422
p.adjustANOVA 0.103



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZIC1 11564
GBX2 9673
TFAP2B 9377
MSX1 8393
PAX3 8375
WNT3A 8366
SOX2 7488
PAX7 7272
DLX5 6973
BMP4 6751
FGF4 3879
TFAP2C 3854
MYB 3783
CTNNB1 -333
TCF7L1 -1676
TFAP2A -10219

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZIC1 11564
GBX2 9673
TFAP2B 9377
MSX1 8393
PAX3 8375
WNT3A 8366
SOX2 7488
PAX7 7272
DLX5 6973
BMP4 6751
FGF4 3879
TFAP2C 3854
MYB 3783
CTNNB1 -333
TCF7L1 -1676
TFAP2A -10219


Antimicrobial peptides

Antimicrobial peptides
118
set Antimicrobial peptides
setSize 79
pANOVA 9.67e-11
s.dist 0.421
p.adjustANOVA 4.86e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
HTN1 11815.0
ITLN1 11712.0
S100A7 11670.0
CCR2 11662.0
DEFB133 11599.0
HTN3 11582.0
LYZ 11557.0
RNASE6 11547.0
DEFB113 11464.0
DEFB116 11371.0
DEFB119 11287.0
REG3G 11240.0
DEFB118 11237.0
DEFB114 11213.0
DEFA4 11146.0
BPIFA1 11113.0
DEFB103A 11037.5
DEFA5 10992.0
RNASE3 10988.0
DEFA1 10974.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HTN1 11815.0
ITLN1 11712.0
S100A7 11670.0
CCR2 11662.0
DEFB133 11599.0
HTN3 11582.0
LYZ 11557.0
RNASE6 11547.0
DEFB113 11464.0
DEFB116 11371.0
DEFB119 11287.0
REG3G 11240.0
DEFB118 11237.0
DEFB114 11213.0
DEFA4 11146.0
BPIFA1 11113.0
DEFB103A 11037.5
DEFA5 10992.0
RNASE3 10988.0
DEFA1 10974.0
DEFA3 10974.0
PDZD11 10739.0
S100A8 10710.0
DEFB121 10678.0
CHGA 10641.0
DCD 10629.0
PGLYRP4 10624.0
TLR1 10582.0
PGLYRP3 10550.0
BPIFB6 10523.0
S100A7A 10474.0
DEFB135 10406.0
DEFA6 10402.0
REG3A 10292.0
BPIFA2 10225.0
DEFB136 10072.0
DEFB124 9944.0
EPPIN 9831.0
CTSG 9320.0
PRTN3 8475.0
BPI 8243.0
DEFB123 7664.0
BPIFB1 6987.0
CCR6 6450.0
DEFB115 6231.0
LTF 6135.0
DEFB125 5903.0
BPIFB4 5329.0
DEFB126 4995.0
PLA2G2A 2552.0
DEFB128 2190.0
PGLYRP2 2050.0
DEFB127 1288.0
ATOX1 903.0
ATP7A 660.0
GNLY 659.0
DEFB108B 239.0
SEMG1 -57.0
DEFB132 -276.0
S100A9 -848.0
ELANE -917.0
CAMP -921.0
PI3 -978.0
BPIFB2 -1070.0
SLC11A1 -1730.0
DEFB129 -1733.0
CLU -2655.0
PGLYRP1 -3622.0
DEFB104A -3835.5
PRSS3 -3921.0
DEFB1 -4158.0
TLR2 -5282.0
DEFB134 -5459.0
RNASE8 -7176.0
ART1 -7974.0
CD4 -8591.0
RNASE7 -9821.0
LCN2 -10144.0
LEAP2 -10658.0


CLEC7A/inflammasome pathway

CLEC7A/inflammasome pathway
202
set CLEC7A/inflammasome pathway
setSize 6
pANOVA 0.0761
s.dist -0.418
p.adjustANOVA 0.431



Top enriched genes

Top 20 genes
GeneID Gene Rank
PYCARD -9180
CASP8 -7685
RELA -5693
NFKB1 -3083
IL1B -1477
MALT1 383

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PYCARD -9180
CASP8 -7685
RELA -5693
NFKB1 -3083
IL1B -1477
MALT1 383


Activation of the phototransduction cascade

Activation of the phototransduction cascade
81
set Activation of the phototransduction cascade
setSize 11
pANOVA 0.017
s.dist -0.416
p.adjustANOVA 0.236



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDE6G -9397
GNB1 -9151
PDE6B -9103
PDE6A -8612
GNAT1 -7039
GNGT1 -6465
RHO -4695
CNGB1 -3831
SAG -2722
SLC24A1 1128
CNGA1 11199

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDE6G -9397
GNB1 -9151
PDE6B -9103
PDE6A -8612
GNAT1 -7039
GNGT1 -6465
RHO -4695
CNGB1 -3831
SAG -2722
SLC24A1 1128
CNGA1 11199


Epithelial-Mesenchymal Transition (EMT) during gastrulation

Epithelial-Mesenchymal Transition (EMT) during gastrulation
510
set Epithelial-Mesenchymal Transition (EMT) during gastrulation
setSize 7
pANOVA 0.0602
s.dist -0.41
p.adjustANOVA 0.39



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLDN7 -10994
OCLN -9111
CDH1 -8854
FGFR1 -7705
EOMES -3817
TBXT 2986
SNAI1 6954

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLDN7 -10994
OCLN -9111
CDH1 -8854
FGFR1 -7705
EOMES -3817
TBXT 2986
SNAI1 6954


Reversible hydration of carbon dioxide

Reversible hydration of carbon dioxide
1506
set Reversible hydration of carbon dioxide
setSize 12
pANOVA 0.015
s.dist -0.406
p.adjustANOVA 0.223



Top enriched genes

Top 20 genes
GeneID Gene Rank
CA6 -10654
CA14 -10384
CA12 -9769
CA9 -8734
CA5B -7239
CA3 -7158
CA7 -4715
CA5A -1370
CA2 -519
CA4 -28
CA1 -27
CA13 8883

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CA6 -10654
CA14 -10384
CA12 -9769
CA9 -8734
CA5B -7239
CA3 -7158
CA7 -4715
CA5A -1370
CA2 -519
CA4 -28
CA1 -27
CA13 8883


Loss of MECP2 binding ability to the NCoR/SMRT complex

Loss of MECP2 binding ability to the NCoR/SMRT complex
890
set Loss of MECP2 binding ability to the NCoR/SMRT complex
setSize 7
pANOVA 0.0686
s.dist -0.398
p.adjustANOVA 0.408



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCOR2 -9391
GPS2 -8479
MECP2 -7871
HDAC3 -3920
TBL1XR1 -3347
TBL1X -1788
NCOR1 5273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCOR2 -9391
GPS2 -8479
MECP2 -7871
HDAC3 -3920
TBL1XR1 -3347
TBL1X -1788
NCOR1 5273


Negative feedback regulation of MAPK pathway

Negative feedback regulation of MAPK pathway
1061
set Negative feedback regulation of MAPK pathway
setSize 6
pANOVA 0.0922
s.dist -0.397
p.adjustANOVA 0.463



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAP2K2 -10683
BRAF -6923
MAPK1 -6543
MAPK3 -2855
MAP2K1 785
RAF1 948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAP2K2 -10683
BRAF -6923
MAPK1 -6543
MAPK3 -2855
MAP2K1 785
RAF1 948


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.2.0                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gplots_3.1.3                                       
##  [6] gtools_3.9.5                                       
##  [7] tibble_3.2.1                                       
##  [8] dplyr_1.1.4                                        
##  [9] echarts4r_0.4.5                                    
## [10] png_0.1-8                                          
## [11] gridExtra_2.3                                      
## [12] missMethyl_1.36.0                                  
## [13] beeswarm_0.4.0                                     
## [14] kableExtra_1.3.4                                   
## [15] tictoc_1.2                                         
## [16] HGNChelper_0.8.1                                   
## [17] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [18] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [19] minfi_1.48.0                                       
## [20] bumphunter_1.44.0                                  
## [21] locfit_1.5-9.8                                     
## [22] iterators_1.0.14                                   
## [23] foreach_1.5.2                                      
## [24] Biostrings_2.70.1                                  
## [25] XVector_0.42.0                                     
## [26] SummarizedExperiment_1.32.0                        
## [27] Biobase_2.62.0                                     
## [28] MatrixGenerics_1.14.0                              
## [29] matrixStats_1.2.0                                  
## [30] GenomicRanges_1.54.1                               
## [31] GenomeInfoDb_1.38.2                                
## [32] IRanges_2.36.0                                     
## [33] S4Vectors_0.40.2                                   
## [34] BiocGenerics_0.48.1                                
## [35] eulerr_7.0.0                                       
## [36] limma_3.58.1                                       
## [37] mitch_1.15.2                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.2              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.3            preprocessCore_1.64.0    
##   [7] XML_3.99-0.16             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.8               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.8                httpuv_1.6.13            
##  [19] askpass_1.2.0             doRNG_1.8.6              
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] quadprog_1.5-8            rvest_1.0.3              
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.3             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.6                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] illuminaio_0.44.0         webshot_0.5.5            
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.8           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.3           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] SparseArray_1.2.2         xfun_0.41                
##  [55] HDF5Array_1.30.0          withr_2.5.2              
##  [57] fastmap_1.1.1             rhdf5filters_1.14.1      
##  [59] fansi_1.0.6               openssl_2.1.1            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.58.0           
##  [67] RSQLite_2.3.4             utf8_1.2.4               
##  [69] tidyr_1.3.0               generics_0.1.3           
##  [71] data.table_1.14.10        rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.4         S4Arrays_1.2.0           
##  [77] ggstats_0.5.1             pkgconfig_2.0.3          
##  [79] gtable_0.3.4              blob_1.2.4               
##  [81] siggenes_1.76.0           htmltools_0.5.7          
##  [83] scales_1.3.0              knitr_1.45               
##  [85] rstudioapi_0.15.0         tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-163             
##  [89] curl_5.2.0                org.Hs.eg.db_3.18.0      
##  [91] cachem_1.0.8              rhdf5_2.46.1             
##  [93] stringr_1.5.1             KernSmooth_2.23-22       
##  [95] AnnotationDbi_1.64.1      restfulr_0.0.15          
##  [97] GEOquery_2.70.0           pillar_1.9.0             
##  [99] grid_4.3.2                reshape_0.8.9            
## [101] vctrs_0.6.5               promises_1.2.1           
## [103] dbplyr_2.4.0              xtable_1.8-4             
## [105] evaluate_0.23             readr_2.1.4              
## [107] GenomicFeatures_1.54.1    cli_3.6.2                
## [109] compiler_4.3.2            Rsamtools_2.18.0         
## [111] rlang_1.1.2               crayon_1.5.2             
## [113] rngtools_1.5.2            nor1mix_1.3-2            
## [115] mclust_6.0.1              plyr_1.8.9               
## [117] stringi_1.8.3             viridisLite_0.4.2        
## [119] BiocParallel_1.36.0       munsell_0.5.0            
## [121] Matrix_1.6-1.1            hms_1.1.3                
## [123] sparseMatrixStats_1.14.0  bit64_4.0.5              
## [125] Rhdf5lib_1.24.1           KEGGREST_1.42.0          
## [127] statmod_1.5.0             shiny_1.8.0              
## [129] highr_0.10                memoise_2.0.1            
## [131] bslib_0.6.1               bit_4.0.5

END of report