date generated: 2020-06-03

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                        ab        d36
## 0610009B22Rik -0.30243426  0.9139299
## 0610009E02Rik  0.07205254 -0.8740584
## 0610009L18Rik -0.82607610 -0.6984798
## 0610010F05Rik  0.45523981  1.7576230
## 0610010K14Rik -0.96139367 -1.5168102
## 0610012G03Rik -0.80991370 -1.7438548

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 11874
duplicated_genes_present 0
num_profile_genes_in_sets 6425
num_profile_genes_not_in_sets 5449
profile_pearson_correl -0.09899
profile_spearman_correl -0.09995

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: gsets/ReactomePathways_mouse.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2339
num_genesets_excluded 1105
num_genesets_included 1234

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 213

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.ab s.d36 p.ab p.d36
PI-3K-cascade:FGFR2 10 1.14e-03 1.05e-02 0.696 -0.284000 0.6350 0.119000 5.10e-04
PI-3K-cascade:FGFR4 10 1.14e-03 1.05e-02 0.696 -0.284000 0.6350 0.119000 5.10e-04
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex 15 4.78e-05 9.51e-04 0.677 -0.158000 0.6590 0.288000 1.00e-05
Biotin-transport-and-metabolism 11 9.32e-04 9.26e-03 0.652 -0.043700 0.6500 0.802000 1.89e-04
Peptide-chain-elongation 69 2.23e-18 7.36e-16 0.625 0.004000 -0.6250 0.954000 2.79e-19
Branched-chain-amino-acid-catabolism 20 1.11e-05 2.79e-04 0.614 0.000211 0.6140 0.999000 2.00e-06
Citric-acid-cycle-(TCA-cycle) 22 1.42e-05 3.50e-04 0.608 -0.350000 0.4980 0.004520 5.33e-05
Carnitine-metabolism 12 1.24e-03 1.10e-02 0.603 0.042900 0.6010 0.797000 3.12e-04
Viral-mRNA-Translation 69 3.98e-17 6.45e-15 0.602 -0.001100 -0.6020 0.987000 5.35e-18
Eukaryotic-Translation-Elongation 73 1.21e-17 2.99e-15 0.595 0.005690 -0.5950 0.933000 1.49e-18
Eukaryotic-Translation-Termination 72 3.35e-17 6.45e-15 0.588 -0.021500 -0.5880 0.753000 6.16e-18
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency 80 1.58e-18 7.36e-16 0.587 0.045700 -0.5850 0.481000 1.40e-19
Selenocysteine-synthesis 73 4.18e-17 6.45e-15 0.584 -0.009570 -0.5840 0.888000 6.35e-18
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC) 73 2.35e-16 3.22e-14 0.570 -0.018600 -0.5690 0.783000 4.12e-17
Physiological-factors 11 2.73e-03 2.01e-02 0.569 0.327000 0.4660 0.060300 7.49e-03
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle 50 2.52e-10 1.15e-08 0.567 -0.305000 0.4780 0.000190 5.06e-09
PI-3K-cascade:FGFR3 11 8.02e-03 4.71e-02 0.562 -0.265000 0.4960 0.128000 4.42e-03
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants 14 7.28e-04 7.88e-03 0.557 -0.379000 -0.4080 0.014100 8.27e-03
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer 14 7.28e-04 7.88e-03 0.557 -0.379000 -0.4080 0.014100 8.27e-03
PI-3K-cascade:FGFR1 10 1.41e-02 7.21e-02 0.547 -0.168000 0.5200 0.356000 4.41e-03
Prolactin-receptor-signaling 10 1.02e-02 5.65e-02 0.532 0.206000 0.4900 0.258000 7.29e-03
eNOS-activation 11 9.90e-03 5.53e-02 0.527 0.005080 -0.5270 0.977000 2.48e-03
CS/DS-degradation 10 2.50e-02 1.08e-01 0.520 0.338000 -0.3950 0.064300 3.06e-02
Formation-of-a-pool-of-free-40S-subunits 81 4.27e-15 4.79e-13 0.516 -0.044500 -0.5140 0.489000 1.29e-15
Voltage-gated-Potassium-channels 13 7.56e-03 4.53e-02 0.516 -0.185000 0.4810 0.248000 2.65e-03
SRP-dependent-cotranslational-protein-targeting-to-membrane 92 4.84e-16 5.97e-14 0.509 0.043000 -0.5070 0.477000 4.57e-17
G-beta:gamma-signalling-through-BTK 11 2.10e-02 9.63e-02 0.508 0.371000 -0.3460 0.033100 4.68e-02
Activation-of-G-protein-gated-Potassium-channels 16 2.91e-03 2.10e-02 0.501 0.491000 -0.1000 0.000676 4.88e-01
G-protein-gated-Potassium-channels 16 2.91e-03 2.10e-02 0.501 0.491000 -0.1000 0.000676 4.88e-01
Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits 16 2.91e-03 2.10e-02 0.501 0.491000 -0.1000 0.000676 4.88e-01
Acyl-chain-remodelling-of-PE 13 4.41e-03 3.04e-02 0.501 0.378000 0.3280 0.018200 4.07e-02
G-protein-activation 15 7.14e-03 4.30e-02 0.489 0.414000 -0.2600 0.005490 8.13e-02
Pyruvate-metabolism 26 2.23e-04 3.02e-03 0.484 -0.246000 0.4170 0.030100 2.34e-04
Collagen-chain-trimerization 25 9.17e-05 1.57e-03 0.483 -0.135000 -0.4640 0.244000 5.97e-05
ADP-signalling-through-P2Y-purinoceptor-12 14 1.18e-02 6.34e-02 0.481 0.388000 -0.2840 0.011900 6.55e-02
Thrombin-signalling-through-proteinase-activated-receptors-(PARs) 21 1.37e-03 1.16e-02 0.480 0.336000 -0.3430 0.007640 6.56e-03
Interleukin-7-signaling 15 9.26e-03 5.27e-02 0.478 -0.375000 0.2960 0.011900 4.73e-02
Selenoamino-acid-metabolism 90 2.44e-14 2.51e-12 0.478 -0.030700 -0.4770 0.616000 5.65e-15
G-beta:gamma-signalling-through-CDC42 13 1.79e-02 8.54e-02 0.477 0.326000 -0.3480 0.041900 2.99e-02
G-beta:gamma-signalling-through-PLC-beta 14 1.23e-02 6.52e-02 0.476 0.422000 -0.2200 0.006270 1.55e-01
Presynaptic-function-of-Kainate-receptors 14 1.23e-02 6.52e-02 0.476 0.422000 -0.2200 0.006270 1.55e-01
Basigin-interactions 18 4.17e-03 2.91e-02 0.473 0.343000 -0.3260 0.011800 1.68e-02
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX) 10 4.82e-02 1.71e-01 0.472 0.351000 -0.3150 0.054800 8.46e-02
Interferon-alpha/beta-signaling 35 4.73e-06 1.33e-04 0.468 -0.144000 -0.4450 0.141000 5.18e-06
Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation 15 6.48e-03 3.98e-02 0.467 -0.046100 -0.4640 0.757000 1.85e-03
MECP2-regulates-neuronal-receptors-and-channels 11 2.63e-02 1.13e-01 0.463 0.462000 0.0407 0.008030 8.15e-01
Caspase-mediated-cleavage-of-cytoskeletal-proteins 12 2.30e-02 1.02e-01 0.462 0.060700 -0.4580 0.716000 6.04e-03
Scavenging-by-Class-A-Receptors 14 7.67e-03 4.55e-02 0.461 -0.215000 -0.4070 0.163000 8.32e-03
Peroxisomal-protein-import 52 1.80e-07 7.16e-06 0.460 -0.157000 0.4320 0.050700 7.11e-08
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC) 92 3.46e-13 2.84e-11 0.455 -0.001870 -0.4550 0.975000 4.91e-14


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.ab s.d36 p.ab p.d36
PI-3K-cascade:FGFR2 10 1.14e-03 1.05e-02 0.69600 -0.284000 6.35e-01 1.19e-01 5.10e-04
PI-3K-cascade:FGFR4 10 1.14e-03 1.05e-02 0.69600 -0.284000 6.35e-01 1.19e-01 5.10e-04
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex 15 4.78e-05 9.51e-04 0.67700 -0.158000 6.59e-01 2.88e-01 1.00e-05
Biotin-transport-and-metabolism 11 9.32e-04 9.26e-03 0.65200 -0.043700 6.50e-01 8.02e-01 1.89e-04
Peptide-chain-elongation 69 2.23e-18 7.36e-16 0.62500 0.004000 -6.25e-01 9.54e-01 2.79e-19
Branched-chain-amino-acid-catabolism 20 1.11e-05 2.79e-04 0.61400 0.000211 6.14e-01 9.99e-01 2.00e-06
Citric-acid-cycle-(TCA-cycle) 22 1.42e-05 3.50e-04 0.60800 -0.350000 4.98e-01 4.52e-03 5.33e-05
Carnitine-metabolism 12 1.24e-03 1.10e-02 0.60300 0.042900 6.01e-01 7.97e-01 3.12e-04
Viral-mRNA-Translation 69 3.98e-17 6.45e-15 0.60200 -0.001100 -6.02e-01 9.87e-01 5.35e-18
Eukaryotic-Translation-Elongation 73 1.21e-17 2.99e-15 0.59500 0.005690 -5.95e-01 9.33e-01 1.49e-18
Eukaryotic-Translation-Termination 72 3.35e-17 6.45e-15 0.58800 -0.021500 -5.88e-01 7.53e-01 6.16e-18
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency 80 1.58e-18 7.36e-16 0.58700 0.045700 -5.85e-01 4.81e-01 1.40e-19
Selenocysteine-synthesis 73 4.18e-17 6.45e-15 0.58400 -0.009570 -5.84e-01 8.88e-01 6.35e-18
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC) 73 2.35e-16 3.22e-14 0.57000 -0.018600 -5.69e-01 7.83e-01 4.12e-17
Physiological-factors 11 2.73e-03 2.01e-02 0.56900 0.327000 4.66e-01 6.03e-02 7.49e-03
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle 50 2.52e-10 1.15e-08 0.56700 -0.305000 4.78e-01 1.90e-04 5.06e-09
PI-3K-cascade:FGFR3 11 8.02e-03 4.71e-02 0.56200 -0.265000 4.96e-01 1.28e-01 4.42e-03
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants 14 7.28e-04 7.88e-03 0.55700 -0.379000 -4.08e-01 1.41e-02 8.27e-03
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer 14 7.28e-04 7.88e-03 0.55700 -0.379000 -4.08e-01 1.41e-02 8.27e-03
PI-3K-cascade:FGFR1 10 1.41e-02 7.21e-02 0.54700 -0.168000 5.20e-01 3.56e-01 4.41e-03
Prolactin-receptor-signaling 10 1.02e-02 5.65e-02 0.53200 0.206000 4.90e-01 2.58e-01 7.29e-03
eNOS-activation 11 9.90e-03 5.53e-02 0.52700 0.005080 -5.27e-01 9.77e-01 2.48e-03
CS/DS-degradation 10 2.50e-02 1.08e-01 0.52000 0.338000 -3.95e-01 6.43e-02 3.06e-02
Formation-of-a-pool-of-free-40S-subunits 81 4.27e-15 4.79e-13 0.51600 -0.044500 -5.14e-01 4.89e-01 1.29e-15
Voltage-gated-Potassium-channels 13 7.56e-03 4.53e-02 0.51600 -0.185000 4.81e-01 2.48e-01 2.65e-03
SRP-dependent-cotranslational-protein-targeting-to-membrane 92 4.84e-16 5.97e-14 0.50900 0.043000 -5.07e-01 4.77e-01 4.57e-17
G-beta:gamma-signalling-through-BTK 11 2.10e-02 9.63e-02 0.50800 0.371000 -3.46e-01 3.31e-02 4.68e-02
Activation-of-G-protein-gated-Potassium-channels 16 2.91e-03 2.10e-02 0.50100 0.491000 -1.00e-01 6.76e-04 4.88e-01
G-protein-gated-Potassium-channels 16 2.91e-03 2.10e-02 0.50100 0.491000 -1.00e-01 6.76e-04 4.88e-01
Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits 16 2.91e-03 2.10e-02 0.50100 0.491000 -1.00e-01 6.76e-04 4.88e-01
Acyl-chain-remodelling-of-PE 13 4.41e-03 3.04e-02 0.50100 0.378000 3.28e-01 1.82e-02 4.07e-02
G-protein-activation 15 7.14e-03 4.30e-02 0.48900 0.414000 -2.60e-01 5.49e-03 8.13e-02
Pyruvate-metabolism 26 2.23e-04 3.02e-03 0.48400 -0.246000 4.17e-01 3.01e-02 2.34e-04
Collagen-chain-trimerization 25 9.17e-05 1.57e-03 0.48300 -0.135000 -4.64e-01 2.44e-01 5.97e-05
ADP-signalling-through-P2Y-purinoceptor-12 14 1.18e-02 6.34e-02 0.48100 0.388000 -2.84e-01 1.19e-02 6.55e-02
Thrombin-signalling-through-proteinase-activated-receptors-(PARs) 21 1.37e-03 1.16e-02 0.48000 0.336000 -3.43e-01 7.64e-03 6.56e-03
Interleukin-7-signaling 15 9.26e-03 5.27e-02 0.47800 -0.375000 2.96e-01 1.19e-02 4.73e-02
Selenoamino-acid-metabolism 90 2.44e-14 2.51e-12 0.47800 -0.030700 -4.77e-01 6.16e-01 5.65e-15
G-beta:gamma-signalling-through-CDC42 13 1.79e-02 8.54e-02 0.47700 0.326000 -3.48e-01 4.19e-02 2.99e-02
G-beta:gamma-signalling-through-PLC-beta 14 1.23e-02 6.52e-02 0.47600 0.422000 -2.20e-01 6.27e-03 1.55e-01
Presynaptic-function-of-Kainate-receptors 14 1.23e-02 6.52e-02 0.47600 0.422000 -2.20e-01 6.27e-03 1.55e-01
Basigin-interactions 18 4.17e-03 2.91e-02 0.47300 0.343000 -3.26e-01 1.18e-02 1.68e-02
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX) 10 4.82e-02 1.71e-01 0.47200 0.351000 -3.15e-01 5.48e-02 8.46e-02
Interferon-alpha/beta-signaling 35 4.73e-06 1.33e-04 0.46800 -0.144000 -4.45e-01 1.41e-01 5.18e-06
Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation 15 6.48e-03 3.98e-02 0.46700 -0.046100 -4.64e-01 7.57e-01 1.85e-03
MECP2-regulates-neuronal-receptors-and-channels 11 2.63e-02 1.13e-01 0.46300 0.462000 4.07e-02 8.03e-03 8.15e-01
Caspase-mediated-cleavage-of-cytoskeletal-proteins 12 2.30e-02 1.02e-01 0.46200 0.060700 -4.58e-01 7.16e-01 6.04e-03
Scavenging-by-Class-A-Receptors 14 7.67e-03 4.55e-02 0.46100 -0.215000 -4.07e-01 1.63e-01 8.32e-03
Peroxisomal-protein-import 52 1.80e-07 7.16e-06 0.46000 -0.157000 4.32e-01 5.07e-02 7.11e-08
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC) 92 3.46e-13 2.84e-11 0.45500 -0.001870 -4.55e-01 9.75e-01 4.91e-14
Nonsense-Mediated-Decay-(NMD) 92 3.46e-13 2.84e-11 0.45500 -0.001870 -4.55e-01 9.75e-01 4.91e-14
YAP1--and-WWTR1-(TAZ)-stimulated-gene-expression 13 1.52e-02 7.65e-02 0.45200 0.101000 4.40e-01 5.28e-01 6.01e-03
Collagen-biosynthesis-and-modifying-enzymes 45 5.65e-07 2.05e-05 0.45000 -0.098500 -4.40e-01 2.53e-01 3.40e-07
Attenuation-phase 21 1.31e-03 1.13e-02 0.45000 -0.445000 -7.01e-02 4.21e-04 5.78e-01
Binding-and-Uptake-of-Ligands-by-Scavenger-Receptors 27 1.29e-04 1.99e-03 0.44700 -0.272000 -3.55e-01 1.44e-02 1.42e-03
tRNA-processing-in-the-mitochondrion 17 5.86e-03 3.69e-02 0.44600 0.008350 4.46e-01 9.52e-01 1.45e-03
Smooth-Muscle-Contraction 29 1.95e-04 2.73e-03 0.44600 0.042800 -4.44e-01 6.90e-01 3.57e-05
Thromboxane-signalling-through-TP-receptor 15 1.64e-02 8.14e-02 0.44500 0.223000 -3.85e-01 1.35e-01 9.80e-03
Chondroitin-sulfate-biosynthesis 14 2.30e-02 1.02e-01 0.44400 0.349000 -2.75e-01 2.38e-02 7.54e-02
Synthesis-of-PA 26 2.08e-04 2.85e-03 0.44400 0.357000 2.64e-01 1.65e-03 2.00e-02
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression 90 1.36e-12 7.96e-11 0.44100 -0.081900 -4.33e-01 1.80e-01 1.25e-12
Activation-of-kainate-receptors-upon-glutamate-binding 20 5.24e-03 3.47e-02 0.43900 0.339000 -2.78e-01 8.64e-03 3.14e-02
Glucagon-type-ligand-receptors 13 3.27e-02 1.32e-01 0.43800 0.263000 -3.51e-01 1.01e-01 2.85e-02
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit 92 1.18e-12 7.30e-11 0.43800 -0.072000 -4.32e-01 2.34e-01 8.16e-13
Gap-junction-trafficking 13 2.17e-02 9.79e-02 0.43700 -0.041500 -4.35e-01 7.96e-01 6.59e-03
Glycogen-breakdown-(glycogenolysis) 14 2.21e-02 9.94e-02 0.43600 -0.126000 4.18e-01 4.14e-01 6.80e-03
Formation-of-tubulin-folding-intermediates-by-CCT/TriC 16 6.62e-03 4.04e-02 0.43400 -0.304000 -3.10e-01 3.52e-02 3.21e-02
Post-chaperonin-tubulin-folding-pathway 14 2.13e-02 9.71e-02 0.43200 0.062100 -4.28e-01 6.87e-01 5.58e-03
Retrograde-neurotrophin-signalling 12 2.66e-02 1.14e-01 0.42800 -0.370000 -2.16e-01 2.65e-02 1.95e-01
HDMs-demethylate-histones 21 4.97e-03 3.33e-02 0.42800 -0.227000 3.63e-01 7.13e-02 3.99e-03
Prostacyclin-signalling-through-prostacyclin-receptor 13 3.77e-02 1.45e-01 0.42800 0.236000 -3.58e-01 1.41e-01 2.56e-02
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell 24 1.23e-03 1.10e-02 0.42700 -0.023700 -4.27e-01 8.41e-01 2.99e-04
rRNA-processing-in-the-mitochondrion 20 4.22e-03 2.93e-02 0.42700 -0.019900 4.27e-01 8.78e-01 9.59e-04
GABA-receptor-activation 29 3.69e-04 4.46e-03 0.42700 0.426000 -2.33e-02 7.12e-05 8.28e-01
Cap-dependent-Translation-Initiation 98 9.15e-13 5.95e-11 0.42500 -0.090500 -4.15e-01 1.22e-01 1.32e-12
Eukaryotic-Translation-Initiation 98 9.15e-13 5.95e-11 0.42500 -0.090500 -4.15e-01 1.22e-01 1.32e-12
Phase-2---plateau-phase 12 4.34e-02 1.60e-01 0.42400 -0.089700 4.15e-01 5.90e-01 1.29e-02
ABC-transporters-in-lipid-homeostasis 13 3.07e-02 1.27e-01 0.42400 -0.030500 4.23e-01 8.49e-01 8.33e-03
Defective-B4GALT7-causes-EDS,-progeroid-type 15 2.05e-02 9.46e-02 0.41900 0.048100 -4.16e-01 7.47e-01 5.32e-03
KSRP-(KHSRP)-binds-and-destabilizes-mRNA 15 1.30e-02 6.75e-02 0.41800 -0.340000 -2.43e-01 2.27e-02 1.03e-01
HSF1-dependent-transactivation 31 4.42e-04 5.29e-03 0.41700 -0.402000 1.11e-01 1.09e-04 2.83e-01
Uptake-and-function-of-anthrax-toxins 11 7.47e-02 2.34e-01 0.41500 -0.243000 3.36e-01 1.63e-01 5.35e-02
Activated-NOTCH1-Transmits-Signal-to-the-Nucleus 26 9.04e-04 9.07e-03 0.41400 -0.087600 -4.04e-01 4.40e-01 3.60e-04
Defective-B3GAT3-causes-JDSSDHD 15 2.16e-02 9.79e-02 0.41300 0.022500 -4.13e-01 8.80e-01 5.67e-03
Glutathione-synthesis-and-recycling 10 9.07e-02 2.61e-01 0.41200 -0.150000 3.84e-01 4.11e-01 3.55e-02
NOTCH4-Activation-and-Transmission-of-Signal-to-the-Nucleus 10 8.05e-02 2.45e-01 0.41200 0.042600 -4.10e-01 8.16e-01 2.48e-02
Sema3A-PAK-dependent-Axon-repulsion 12 3.40e-02 1.35e-01 0.41100 -0.285000 -2.97e-01 8.73e-02 7.53e-02
Mitochondrial-Fatty-Acid-Beta-Oxidation 30 7.54e-04 7.95e-03 0.41100 -0.133000 3.89e-01 2.08e-01 2.29e-04
Activation-of-GABAB-receptors 26 1.69e-03 1.33e-02 0.41000 0.404000 -7.09e-02 3.67e-04 5.32e-01
GABA-B-receptor-activation 26 1.69e-03 1.33e-02 0.41000 0.404000 -7.09e-02 3.67e-04 5.32e-01
EPHA-mediated-growth-cone-collapse 13 4.03e-02 1.51e-01 0.40800 0.038600 -4.06e-01 8.10e-01 1.13e-02
Mitochondrial-tRNA-aminoacylation 19 1.35e-02 6.93e-02 0.40800 -0.305000 2.71e-01 2.15e-02 4.11e-02
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol 153 2.39e-18 7.36e-16 0.40700 -0.140000 -3.83e-01 2.80e-03 3.56e-16
Defects-in-vitamin-and-cofactor-metabolism 19 9.41e-03 5.33e-02 0.40700 -0.041100 4.05e-01 7.57e-01 2.25e-03
Defective-B3GALT6-causes-EDSP2-and-SEMDJL1 15 2.94e-02 1.24e-01 0.40500 0.115000 -3.89e-01 4.39e-01 9.17e-03
Heme-biosynthesis 11 7.77e-02 2.41e-01 0.40500 -0.381000 1.35e-01 2.85e-02 4.39e-01
Cooperation-of-Prefoldin-and-TriC/CCT--in-actin-and-tubulin-folding 23 2.13e-03 1.63e-02 0.40400 -0.187000 -3.58e-01 1.21e-01 2.94e-03
Generation-of-second-messenger-molecules 12 3.89e-02 1.47e-01 0.40300 -0.305000 -2.64e-01 6.73e-02 1.14e-01
Signaling-by-NODAL 11 8.68e-02 2.56e-01 0.40200 -0.337000 2.20e-01 5.32e-02 2.07e-01
Repression-of-WNT-target-genes 11 8.99e-02 2.61e-01 0.40000 0.248000 -3.14e-01 1.55e-01 7.10e-02
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA 50 3.79e-06 1.15e-04 0.39800 -0.389000 -8.49e-02 1.94e-06 3.00e-01
Cholesterol-biosynthesis 21 5.83e-03 3.69e-02 0.39800 0.395000 4.48e-02 1.71e-03 7.22e-01
Initial-triggering-of-complement 11 6.04e-02 2.00e-01 0.39800 -0.141000 -3.72e-01 4.17e-01 3.28e-02
Metabolism-of-folate-and-pterines 13 3.78e-02 1.45e-01 0.39700 0.379000 1.17e-01 1.79e-02 4.66e-01
rRNA-processing-in-the-nucleus-and-cytosol 163 1.66e-18 7.36e-16 0.39500 -0.160000 -3.61e-01 4.26e-04 2.10e-15
SHC1-events-in-ERBB4-signaling 10 1.15e-01 3.01e-01 0.39400 0.356000 -1.69e-01 5.14e-02 3.55e-01
RHO-GTPases-activate-PAKs 19 1.64e-02 8.14e-02 0.39400 0.169000 -3.56e-01 2.03e-01 7.30e-03
Purine-ribonucleoside-monophosphate-biosynthesis 12 6.21e-02 2.05e-01 0.39300 -0.393000 2.06e-02 1.85e-02 9.02e-01
FRS-mediated-FGFR2-signaling 12 7.97e-02 2.44e-01 0.39100 -0.212000 3.29e-01 2.03e-01 4.86e-02
FRS-mediated-FGFR4-signaling 12 7.97e-02 2.44e-01 0.39100 -0.212000 3.29e-01 2.03e-01 4.86e-02
p75NTR-signals-via-NF-kB 14 3.80e-02 1.45e-01 0.39000 -0.024500 -3.90e-01 8.74e-01 1.16e-02
NOTCH2-Activation-and-Transmission-of-Signal-to-the-Nucleus 19 9.19e-03 5.27e-02 0.39000 -0.158000 -3.56e-01 2.32e-01 7.22e-03
Influenza-Viral-RNA-Transcription-and-Replication 111 6.16e-12 3.30e-10 0.38900 -0.040400 -3.87e-01 4.63e-01 1.95e-12
Glyoxylate-metabolism-and-glycine-degradation 22 8.18e-03 4.76e-02 0.38800 -0.081600 3.79e-01 5.08e-01 2.07e-03
Glycosphingolipid-metabolism 30 1.73e-03 1.35e-02 0.38500 0.369000 -1.11e-01 4.74e-04 2.92e-01
NF-kB-is-activated-and-signals-survival 11 8.24e-02 2.51e-01 0.38300 -0.037200 -3.82e-01 8.31e-01 2.84e-02
A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis 20 1.31e-02 6.77e-02 0.38300 0.042100 -3.80e-01 7.45e-01 3.24e-03
Prefoldin-mediated-transfer-of-substrate--to-CCT/TriC 21 6.43e-03 3.97e-02 0.38200 -0.198000 -3.27e-01 1.16e-01 9.59e-03
Molecules-associated-with-elastic-fibres 25 4.54e-03 3.09e-02 0.38000 0.379000 -2.34e-02 1.03e-03 8.39e-01
Assembly-of-collagen-fibrils-and-other-multimeric-structures 40 8.71e-05 1.56e-03 0.38000 -0.153000 -3.47e-01 9.38e-02 1.46e-04
Golgi-Cisternae-Pericentriolar-Stack-Reorganization 10 9.41e-02 2.67e-01 0.37700 0.290000 2.41e-01 1.12e-01 1.88e-01
Pexophagy 10 1.35e-01 3.31e-01 0.37700 -0.350000 1.39e-01 5.51e-02 4.46e-01
TGF-beta-receptor-signaling-in-EMT-(epithelial-to-mesenchymal-transition) 13 6.38e-02 2.08e-01 0.37600 0.018300 -3.75e-01 9.09e-01 1.91e-02
Assembly-of-active-LPL-and-LIPC-lipase-complexes 10 1.42e-01 3.41e-01 0.37600 -0.326000 1.86e-01 7.40e-02 3.09e-01
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex 44 9.09e-05 1.57e-03 0.37400 -0.000526 -3.74e-01 9.95e-01 1.77e-05
Peroxisomal-lipid-metabolism 23 5.70e-03 3.67e-02 0.37300 0.131000 3.49e-01 2.75e-01 3.74e-03
Gap-junction-trafficking-and-regulation 15 4.37e-02 1.61e-01 0.37300 0.018700 -3.73e-01 9.00e-01 1.24e-02
Synthesis-of-PC 21 9.26e-03 5.27e-02 0.37000 0.158000 3.34e-01 2.09e-01 8.03e-03
Metabolism-of-steroid-hormones 13 8.38e-02 2.53e-01 0.37000 0.333000 -1.61e-01 3.78e-02 3.14e-01
Regulation-of-TP53-Activity-through-Methylation 16 2.97e-02 1.24e-01 0.36900 -0.344000 -1.33e-01 1.72e-02 3.56e-01
Acyl-chain-remodelling-of-PS 11 9.93e-02 2.75e-01 0.36700 0.364000 5.12e-02 3.67e-02 7.69e-01
Acyl-chain-remodelling-of-PC 14 4.42e-02 1.62e-01 0.36700 0.310000 1.97e-01 4.44e-02 2.03e-01
Regulation-of-ornithine-decarboxylase-(ODC) 47 6.05e-05 1.15e-03 0.36700 -0.365000 -3.26e-02 1.49e-05 6.99e-01
rRNA-modification-in-the-nucleus-and-cytosol 53 8.00e-06 2.15e-04 0.36600 -0.297000 -2.13e-01 1.82e-04 7.27e-03
Constitutive-Signaling-by-Overexpressed-ERBB2 11 1.35e-01 3.31e-01 0.36400 0.300000 -2.06e-01 8.48e-02 2.36e-01
TICAM1-dependent-activation-of-IRF3/IRF7 10 1.13e-01 2.99e-01 0.36400 -0.186000 -3.13e-01 3.10e-01 8.62e-02
Inwardly-rectifying-K+-channels 20 2.11e-02 9.67e-02 0.36300 0.358000 -5.71e-02 5.57e-03 6.59e-01
Cristae-formation 13 8.48e-02 2.53e-01 0.36300 -0.086900 3.52e-01 5.87e-01 2.80e-02
Collagen-formation 63 2.23e-06 7.45e-05 0.36200 -0.086800 -3.51e-01 2.34e-01 1.46e-06
Metabolism-of-polyamines 53 2.65e-05 5.95e-04 0.36000 -0.359000 -3.00e-02 6.35e-06 7.06e-01
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation 46 8.95e-05 1.57e-03 0.35900 -0.351000 -7.68e-02 3.93e-05 3.68e-01
Retinoid-metabolism-and-transport 22 1.54e-02 7.75e-02 0.35900 0.046200 -3.56e-01 7.07e-01 3.89e-03
Regulation-of-KIT-signaling 13 6.50e-02 2.10e-01 0.35800 -0.319000 -1.63e-01 4.64e-02 3.08e-01
Influenza-Infection 127 9.15e-12 4.71e-10 0.35800 -0.077700 -3.49e-01 1.31e-01 1.19e-11
p75NTR-recruits-signalling-complexes 11 1.05e-01 2.86e-01 0.35700 -0.118000 -3.37e-01 4.97e-01 5.31e-02
Activation-of-the-AP-1-family-of-transcription-factors 10 1.21e-01 3.12e-01 0.35700 0.272000 2.31e-01 1.37e-01 2.06e-01
tRNA-Aminoacylation 37 1.33e-03 1.13e-02 0.35600 -0.333000 1.27e-01 4.62e-04 1.81e-01
Interleukin-6-signaling 10 1.30e-01 3.28e-01 0.35400 0.150000 3.20e-01 4.12e-01 7.95e-02
Regulation-of-expression-of-SLITs-and-ROBOs 131 5.21e-12 2.92e-10 0.35300 -0.108000 -3.36e-01 3.36e-02 3.16e-11
mRNA-decay-by-3'-to-5'-exoribonuclease 15 4.57e-02 1.63e-01 0.35200 -0.272000 -2.23e-01 6.82e-02 1.35e-01
Cross-presentation-of-soluble-exogenous-antigens-(endosomes) 44 2.02e-04 2.80e-03 0.35100 -0.345000 -6.69e-02 7.62e-05 4.43e-01
Formation-of-the-cornified-envelope 14 9.22e-02 2.64e-01 0.35100 -0.175000 3.04e-01 2.58e-01 4.87e-02
Nitric-oxide-stimulates-guanylate-cyclase 13 1.09e-01 2.94e-01 0.35000 0.157000 -3.13e-01 3.29e-01 5.06e-02
Cytosolic-tRNA-aminoacylation 19 3.08e-02 1.27e-01 0.35000 -0.349000 2.00e-02 8.40e-03 8.80e-01
Synthesis-of-PIPs-at-the-late-endosome-membrane 10 1.47e-01 3.48e-01 0.34900 0.075200 3.40e-01 6.81e-01 6.24e-02
ATF4-activates-genes-in-response-to-endoplasmic-reticulum--stress 23 1.11e-02 6.06e-02 0.34900 -0.123000 -3.26e-01 3.07e-01 6.81e-03
Vif-mediated-degradation-of-APOBEC3G 47 1.29e-04 1.99e-03 0.34800 -0.338000 -8.09e-02 6.16e-05 3.38e-01
NCAM1-interactions 24 8.09e-03 4.73e-02 0.34700 -0.242000 -2.49e-01 4.02e-02 3.47e-02
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A 47 1.22e-04 1.98e-03 0.34700 -0.334000 -9.50e-02 7.49e-05 2.60e-01
p53-Independent-DNA-Damage-Response 47 1.22e-04 1.98e-03 0.34700 -0.334000 -9.50e-02 7.49e-05 2.60e-01
p53-Independent-G1/S-DNA-damage-checkpoint 47 1.22e-04 1.98e-03 0.34700 -0.334000 -9.50e-02 7.49e-05 2.60e-01
Signaling-by-cytosolic-FGFR1-fusion-mutants 18 2.90e-02 1.23e-01 0.34700 0.153000 3.11e-01 2.60e-01 2.22e-02
Complex-I-biogenesis 53 2.80e-05 6.16e-04 0.34600 -0.285000 -1.96e-01 3.32e-04 1.35e-02
FGFR1-mutant-receptor-activation 24 1.18e-02 6.34e-02 0.34400 0.060000 3.39e-01 6.11e-01 4.10e-03
Glycogen-storage-diseases 12 1.44e-01 3.45e-01 0.34400 -0.276000 2.05e-01 9.82e-02 2.19e-01
Interleukin-15-signaling 12 1.11e-01 2.97e-01 0.34300 0.049700 3.39e-01 7.66e-01 4.19e-02
GAB1-signalosome 12 1.14e-01 3.00e-01 0.34200 0.043400 3.39e-01 7.95e-01 4.20e-02
Insulin-processing 21 2.36e-02 1.04e-01 0.34200 0.341000 1.61e-02 6.78e-03 8.98e-01
Autodegradation-of-the-E3-ubiquitin-ligase-COP1 47 1.68e-04 2.42e-03 0.34100 -0.327000 -9.60e-02 1.06e-04 2.55e-01
Regulation-of-Apoptosis 49 1.63e-04 2.38e-03 0.34000 -0.339000 -3.08e-02 4.09e-05 7.10e-01
Nucleobase-biosynthesis 15 7.07e-02 2.24e-01 0.34000 -0.339000 -1.77e-02 2.29e-02 9.06e-01
SUMOylation-of-immune-response-proteins 10 1.97e-01 4.11e-01 0.33900 0.317000 -1.18e-01 8.23e-02 5.18e-01
Cell-extracellular-matrix-interactions 16 5.03e-02 1.76e-01 0.33800 -0.297000 -1.61e-01 4.00e-02 2.65e-01
Vpu-mediated-degradation-of-CD4 47 2.72e-04 3.46e-03 0.33600 -0.333000 -4.30e-02 7.85e-05 6.10e-01
Degradation-of-AXIN 51 1.29e-04 1.99e-03 0.33600 -0.331000 -5.49e-02 4.34e-05 4.98e-01
RHO-GTPases-Activate-ROCKs 17 6.69e-02 2.15e-01 0.33600 0.119000 -3.14e-01 3.96e-01 2.51e-02
Amino-acid-transport-across-the-plasma-membrane 20 3.88e-02 1.47e-01 0.33300 0.329000 -5.57e-02 1.10e-02 6.67e-01
Effects-of-PIP2-hydrolysis 20 4.09e-02 1.52e-01 0.33300 0.082600 -3.23e-01 5.23e-01 1.25e-02
Cellular-response-to-hypoxia 66 1.93e-05 4.59e-04 0.33100 -0.331000 5.90e-03 3.42e-06 9.34e-01
Purine-catabolism 16 9.16e-02 2.63e-01 0.33100 0.199000 -2.64e-01 1.68e-01 6.77e-02
Hedgehog-ligand-biogenesis 54 1.28e-04 1.99e-03 0.33000 -0.330000 -1.50e-02 2.78e-05 8.49e-01
Regulation-of-RUNX3-expression-and-activity 51 1.43e-04 2.15e-03 0.32900 -0.313000 -1.04e-01 1.13e-04 2.01e-01
Hyaluronan-metabolism 11 1.98e-01 4.11e-01 0.32900 0.237000 -2.28e-01 1.74e-01 1.91e-01
GRB2-events-in-ERBB2-signaling 12 1.49e-01 3.51e-01 0.32700 0.325000 -3.55e-02 5.12e-02 8.31e-01
Ubiquitin-dependent-degradation-of-Cyclin-D 48 3.04e-04 3.79e-03 0.32600 -0.316000 -8.32e-02 1.57e-04 3.19e-01
SEMA3A-Plexin-repulsion-signaling-by-inhibiting-Integrin-adhesion 11 1.51e-01 3.52e-01 0.32600 -0.122000 -3.02e-01 4.82e-01 8.29e-02
Gluconeogenesis 24 2.02e-02 9.34e-02 0.32600 0.022700 3.25e-01 8.47e-01 5.88e-03
Degradation-of-DVL 52 1.64e-04 2.38e-03 0.32600 -0.316000 -8.02e-02 8.36e-05 3.18e-01
Hh-mutants-abrogate-ligand-secretion 51 2.63e-04 3.38e-03 0.32500 -0.324000 -2.40e-02 6.34e-05 7.67e-01
Hh-mutants-that-don't-undergo-autocatalytic-processing-are-degraded-by-ERAD 51 2.63e-04 3.38e-03 0.32500 -0.324000 -2.40e-02 6.34e-05 7.67e-01
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint 51 1.75e-04 2.49e-03 0.32400 -0.302000 -1.17e-01 1.89e-04 1.47e-01
Transcriptional-activation-of-mitochondrial-biogenesis 49 8.89e-04 9.00e-03 0.32400 -0.263000 1.88e-01 1.44e-03 2.26e-02
Regulation-of-PTEN-stability-and-activity 63 3.35e-05 7.25e-04 0.32400 -0.319000 -5.67e-02 1.23e-05 4.37e-01
Miscellaneous-transport-and-binding-events 16 7.72e-02 2.40e-01 0.32400 0.016600 3.23e-01 9.08e-01 2.52e-02
Downstream-signaling-of-activated-FGFR2 17 8.60e-02 2.55e-01 0.32400 -0.168000 2.77e-01 2.31e-01 4.84e-02
Downstream-signaling-of-activated-FGFR4 17 8.60e-02 2.55e-01 0.32400 -0.168000 2.77e-01 2.31e-01 4.84e-02
Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements 80 1.62e-06 5.56e-05 0.32200 -0.303000 -1.09e-01 2.79e-06 9.14e-02
GRB2:SOS-provides-linkage-to-MAPK-signaling-for-Integrins 12 1.50e-01 3.51e-01 0.32200 0.322000 1.33e-02 5.38e-02 9.37e-01
ADP-signalling-through-P2Y-purinoceptor-1 17 9.06e-02 2.61e-01 0.32100 0.257000 -1.93e-01 6.66e-02 1.69e-01
Regulation-of-RAS-by-GAPs 62 4.14e-05 8.52e-04 0.31900 -0.302000 -1.03e-01 4.00e-05 1.62e-01
Metabolism-of-fat-soluble-vitamins 24 2.72e-02 1.16e-01 0.31900 0.034200 -3.17e-01 7.72e-01 7.25e-03
Chondroitin-sulfate/dermatan-sulfate-metabolism 40 3.97e-03 2.80e-02 0.31900 0.205000 -2.44e-01 2.52e-02 7.59e-03
Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS) 26 2.41e-02 1.06e-01 0.31800 0.102000 -3.01e-01 3.70e-01 7.94e-03
SCF-beta-TrCP-mediated-degradation-of-Emi1 49 5.67e-04 6.66e-03 0.31700 -0.317000 -1.10e-02 1.27e-04 8.94e-01
TNF-receptor-superfamily-(TNFSF)-members-mediating-non-canonical-NF-kB-pathway 10 2.52e-01 4.84e-01 0.31700 0.177000 -2.63e-01 3.33e-01 1.50e-01
Negative-regulation-of-NOTCH4-signaling 51 2.80e-04 3.52e-03 0.31700 -0.300000 -1.00e-01 2.10e-04 2.15e-01
FOXO-mediated-transcription-of-cell-death-genes 14 1.42e-01 3.41e-01 0.31600 -0.287000 1.31e-01 6.27e-02 3.95e-01
Signal-amplification 22 5.03e-02 1.76e-01 0.31600 0.245000 -1.98e-01 4.64e-02 1.07e-01
Other-semaphorin-interactions 16 7.87e-02 2.43e-01 0.31500 -0.095300 -3.00e-01 5.10e-01 3.76e-02
PI3K-Cascade 25 2.98e-02 1.24e-01 0.31500 -0.108000 2.96e-01 3.50e-01 1.04e-02
Regulation-of-FOXO-transcriptional-activity-by-acetylation 10 2.56e-01 4.85e-01 0.31500 -0.177000 2.60e-01 3.31e-01 1.54e-01
Cargo-concentration-in-the-ER 21 3.78e-02 1.45e-01 0.31500 0.068000 3.07e-01 5.90e-01 1.49e-02
Laminin-interactions 20 3.82e-02 1.45e-01 0.31400 -0.256000 -1.82e-01 4.76e-02 1.59e-01
Interleukin-37-signaling 16 1.11e-01 2.97e-01 0.31300 0.286000 -1.27e-01 4.76e-02 3.78e-01
Mucopolysaccharidoses 11 1.79e-01 3.88e-01 0.31300 0.298000 9.47e-02 8.71e-02 5.87e-01
Signaling-by-FGFR3-in-disease 15 1.36e-01 3.31e-01 0.31300 -0.205000 2.36e-01 1.69e-01 1.14e-01
Signaling-by-FGFR3-point-mutants-in-cancer 15 1.36e-01 3.31e-01 0.31300 -0.205000 2.36e-01 1.69e-01 1.14e-01
Gene-and-protein-expression-by-JAK-STAT-signaling-after-Interleukin-12-stimulation 31 1.52e-02 7.65e-02 0.31200 0.147000 -2.75e-01 1.56e-01 8.01e-03
MAPK6/MAPK4-signaling 76 6.60e-06 1.81e-04 0.31200 -0.287000 -1.21e-01 1.53e-05 6.81e-02
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes 21 3.95e-02 1.48e-01 0.31200 0.076700 3.02e-01 5.43e-01 1.66e-02
Stabilization-of-p53 51 3.64e-04 4.45e-03 0.31100 -0.294000 -1.03e-01 2.89e-04 2.04e-01
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes 26 3.01e-02 1.25e-01 0.31100 -0.138000 2.79e-01 2.23e-01 1.39e-02
Leading-Strand-Synthesis 11 2.03e-01 4.16e-01 0.31100 0.017100 -3.11e-01 9.22e-01 7.45e-02
Polymerase-switching 11 2.03e-01 4.16e-01 0.31100 0.017100 -3.11e-01 9.22e-01 7.45e-02
rRNA-processing 183 3.75e-13 2.89e-11 0.31100 -0.145000 -2.75e-01 7.27e-04 1.63e-10
HSP90-chaperone-cycle-for-steroid-hormone-receptors-(SHR) 33 7.62e-03 4.54e-02 0.31100 -0.310000 -2.20e-02 2.08e-03 8.27e-01
FRS-mediated-FGFR3-signaling 13 1.83e-01 3.93e-01 0.30900 -0.202000 2.35e-01 2.08e-01 1.43e-01
JNK-(c-Jun-kinases)-phosphorylation-and--activation-mediated-by-activated-human-TAK1 17 7.23e-02 2.28e-01 0.30600 0.166000 2.57e-01 2.35e-01 6.69e-02
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha 59 2.48e-04 3.26e-03 0.30600 -0.306000 5.00e-03 4.90e-05 9.47e-01
O-glycosylation-of-TSR-domain-containing-proteins 27 2.82e-02 1.19e-01 0.30500 0.093400 -2.90e-01 4.01e-01 9.11e-03
Erythropoietin-activates-Phosphoinositide-3-kinase-(PI3K) 10 2.65e-01 4.90e-01 0.30500 -0.291000 8.91e-02 1.11e-01 6.26e-01
Cleavage-of-the-damaged-pyrimidine 12 1.70e-01 3.76e-01 0.30400 -0.291000 -8.75e-02 8.08e-02 6.00e-01
Depyrimidination 12 1.70e-01 3.76e-01 0.30400 -0.291000 -8.75e-02 8.08e-02 6.00e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-pyrimidine 12 1.70e-01 3.76e-01 0.30400 -0.291000 -8.75e-02 8.08e-02 6.00e-01
WNT5A-dependent-internalization-of-FZD4 14 1.35e-01 3.31e-01 0.30400 -0.301000 -3.78e-02 5.09e-02 8.06e-01
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters 15 1.29e-01 3.26e-01 0.30400 -0.302000 3.32e-02 4.31e-02 8.24e-01
FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis 50 8.50e-04 8.67e-03 0.30200 -0.300000 -3.77e-02 2.45e-04 6.45e-01
CD209-(DC-SIGN)-signaling 16 9.83e-02 2.74e-01 0.30100 -0.284000 -9.69e-02 4.89e-02 5.02e-01
Glycogen-metabolism 24 5.16e-02 1.78e-01 0.30000 -0.170000 2.47e-01 1.49e-01 3.61e-02
Vitamin-B5-(pantothenate)-metabolism 15 1.10e-01 2.94e-01 0.30000 0.142000 2.64e-01 3.41e-01 7.67e-02
PERK-regulates-gene-expression 28 1.69e-02 8.23e-02 0.30000 -0.120000 -2.75e-01 2.74e-01 1.19e-02
Other-interleukin-signaling 16 1.37e-01 3.33e-01 0.30000 0.146000 -2.62e-01 3.11e-01 7.01e-02
Complement-cascade 22 3.88e-02 1.47e-01 0.29800 -0.180000 -2.38e-01 1.44e-01 5.32e-02
CDT1-association-with-the-CDC6:ORC:origin-complex 52 7.42e-04 7.89e-03 0.29800 -0.295000 -4.71e-02 2.39e-04 5.58e-01
Elastic-fibre-formation 33 1.35e-02 6.93e-02 0.29700 0.295000 -3.12e-02 3.34e-03 7.56e-01
G-beta:gamma-signalling-through-PI3Kgamma 18 1.10e-01 2.94e-01 0.29600 0.124000 -2.69e-01 3.61e-01 4.82e-02
Regulated-proteolysis-of-p75NTR 10 3.03e-01 5.35e-01 0.29400 0.152000 -2.52e-01 4.06e-01 1.68e-01
Keratinization 15 1.65e-01 3.70e-01 0.29400 -0.136000 2.61e-01 3.63e-01 8.04e-02
AKT-phosphorylates-targets-in-the-cytosol 14 1.81e-01 3.91e-01 0.29400 -0.103000 2.75e-01 5.03e-01 7.49e-02
Defective-CFTR-causes-cystic-fibrosis 55 7.16e-04 7.88e-03 0.29300 -0.293000 -2.15e-02 1.77e-04 7.83e-01
Sealing-of-the-nuclear-envelope-(NE)-by-ESCRT-III 21 5.96e-02 1.99e-01 0.29100 -0.071000 -2.82e-01 5.74e-01 2.51e-02
Translation-initiation-complex-formation 50 1.28e-03 1.12e-02 0.29100 -0.062100 -2.84e-01 4.48e-01 5.09e-04
Ribosomal-scanning-and-start-codon-recognition 51 1.22e-03 1.10e-02 0.29100 -0.045800 -2.87e-01 5.72e-01 3.92e-04
Glycerophospholipid-biosynthesis 89 4.63e-06 1.33e-04 0.29000 0.157000 2.44e-01 1.07e-02 7.15e-05
HSF1-activation 24 4.46e-02 1.62e-01 0.28900 -0.287000 -3.40e-02 1.48e-02 7.73e-01
Constitutive-Signaling-by-AKT1-E17K-in-Cancer 25 5.15e-02 1.78e-01 0.28900 -0.096300 2.73e-01 4.05e-01 1.82e-02
alpha-linolenic-(omega3)-and-linoleic-(omega6)-acid-metabolism 10 2.61e-01 4.87e-01 0.28700 0.117000 2.63e-01 5.22e-01 1.51e-01
alpha-linolenic-acid-(ALA)-metabolism 10 2.61e-01 4.87e-01 0.28700 0.117000 2.63e-01 5.22e-01 1.51e-01
Suppression-of-phagosomal-maturation 12 2.24e-01 4.49e-01 0.28700 -0.287000 2.89e-03 8.51e-02 9.86e-01
NOTCH3-Activation-and-Transmission-of-Signal-to-the-Nucleus 24 4.30e-02 1.59e-01 0.28700 -0.080400 -2.75e-01 4.96e-01 1.96e-02
Transcription-of-E2F-targets-under-negative-control-by-DREAM-complex 16 1.22e-01 3.15e-01 0.28600 0.268000 9.86e-02 6.34e-02 4.95e-01
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S 51 1.48e-03 1.22e-02 0.28500 -0.057800 -2.79e-01 4.75e-01 5.63e-04
N-Glycan-antennae-elongation 12 2.65e-01 4.90e-01 0.28500 0.221000 -1.79e-01 1.84e-01 2.82e-01
Adrenaline,noradrenaline-inhibits-insulin-secretion 19 1.14e-01 3.01e-01 0.28500 0.264000 -1.05e-01 4.62e-02 4.26e-01
Respiratory-electron-transport 97 3.04e-06 9.61e-05 0.28400 -0.256000 -1.23e-01 1.32e-05 3.71e-02
UCH-proteinases 79 5.05e-05 9.89e-04 0.28400 -0.281000 -4.29e-02 1.62e-05 5.10e-01
DNA-strand-elongation 24 6.31e-02 2.07e-01 0.28400 0.083700 -2.71e-01 4.78e-01 2.14e-02
ABC-family-proteins-mediated-transport 85 7.22e-05 1.35e-03 0.28300 -0.263000 1.03e-01 2.77e-05 1.02e-01
Infection-with-Mycobacterium-tuberculosis 24 4.24e-02 1.57e-01 0.28200 -0.184000 -2.14e-01 1.20e-01 7.03e-02
Regulation-of-RUNX2-expression-and-activity 60 8.24e-04 8.54e-03 0.28100 -0.281000 8.20e-03 1.70e-04 9.13e-01
Nucleobase-catabolism 25 6.46e-02 2.10e-01 0.28100 0.251000 -1.25e-01 2.97e-02 2.81e-01
cGMP-effects 11 3.07e-01 5.38e-01 0.28100 0.200000 -1.96e-01 2.50e-01 2.59e-01
Assembly-Of-The-HIV-Virion 13 1.91e-01 4.05e-01 0.28000 -0.257000 -1.11e-01 1.08e-01 4.90e-01
Response-of-EIF2AK1-(HRI)-to-heme-deficiency 15 1.95e-01 4.10e-01 0.27900 0.120000 -2.52e-01 4.21e-01 9.08e-02
Adherens-junctions-interactions 15 2.02e-01 4.15e-01 0.27900 -0.226000 1.65e-01 1.30e-01 2.70e-01
G1/S-Specific-Transcription 18 1.07e-01 2.91e-01 0.27900 0.267000 8.05e-02 5.02e-02 5.54e-01
G-protein-beta:gamma-signalling 23 8.80e-02 2.58e-01 0.27800 0.183000 -2.10e-01 1.28e-01 8.20e-02
Base-Excision-Repair,-AP-Site-Formation 13 1.98e-01 4.11e-01 0.27700 -0.256000 -1.07e-01 1.10e-01 5.05e-01
CRMPs-in-Sema3A-signaling 11 2.48e-01 4.81e-01 0.27700 -0.144000 -2.37e-01 4.07e-01 1.74e-01
Chemokine-receptors-bind-chemokines 12 2.40e-01 4.71e-01 0.27700 -0.275000 -3.44e-02 9.95e-02 8.37e-01
PI3K-events-in-ERBB2-signaling 12 2.20e-01 4.44e-01 0.27600 0.148000 2.33e-01 3.74e-01 1.62e-01
Synthesis-of-PIPs-at-the-Golgi-membrane 15 1.61e-01 3.68e-01 0.27600 0.265000 7.88e-02 7.57e-02 5.97e-01
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity 21 1.13e-01 3.00e-01 0.27600 -0.169000 2.17e-01 1.79e-01 8.47e-02
Mitochondrial-translation-termination 88 1.59e-05 3.85e-04 0.27600 -0.183000 -2.06e-01 3.12e-03 8.35e-04
p53-Dependent-G1-DNA-Damage-Response 56 1.03e-03 9.73e-03 0.27500 -0.248000 -1.19e-01 1.34e-03 1.25e-01
p53-Dependent-G1/S-DNA-damage-checkpoint 56 1.03e-03 9.73e-03 0.27500 -0.248000 -1.19e-01 1.34e-03 1.25e-01
Carboxyterminal-post-translational-modifications-of-tubulin 20 8.41e-02 2.53e-01 0.27500 -0.133000 -2.40e-01 3.03e-01 6.29e-02
RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs 62 4.65e-04 5.52e-03 0.27500 -0.236000 -1.40e-01 1.31e-03 5.67e-02
Assembly-of-the-pre-replicative-complex 59 7.67e-04 8.02e-03 0.27500 -0.255000 -1.01e-01 6.99e-04 1.80e-01
PCP/CE-pathway 80 8.74e-05 1.56e-03 0.27500 -0.272000 -3.98e-02 2.71e-05 5.39e-01
Butyrate-Response-Factor-1-(BRF1)-binds-and-destabilizes-mRNA 16 1.41e-01 3.40e-01 0.27400 -0.125000 -2.44e-01 3.87e-01 9.18e-02
Integrin-cell-surface-interactions 42 1.07e-02 5.90e-02 0.27300 0.058100 -2.67e-01 5.15e-01 2.78e-03
Association-of-TriC/CCT-with-target-proteins-during-biosynthesis 32 3.70e-02 1.43e-01 0.27300 -0.132000 2.39e-01 1.98e-01 1.93e-02
Signaling-by-ROBO-receptors 167 2.20e-09 9.35e-08 0.27300 -0.108000 -2.50e-01 1.61e-02 2.60e-08
Protein-ubiquitination 57 2.29e-03 1.74e-02 0.27200 -0.066600 2.64e-01 3.85e-01 5.68e-04
Insertion-of-tail-anchored-proteins-into-the-endoplasmic-reticulum-membrane 21 1.18e-01 3.09e-01 0.27200 0.148000 -2.28e-01 2.39e-01 7.06e-02
Meiotic-synapsis 20 1.34e-01 3.31e-01 0.27200 0.203000 -1.80e-01 1.16e-01 1.63e-01
Activation-of-IRF3/IRF7-mediated-by-TBK1/IKK-epsilon 12 2.29e-01 4.54e-01 0.27200 -0.201000 -1.82e-01 2.27e-01 2.75e-01
Mitochondrial-translation-elongation 88 2.25e-05 5.14e-04 0.27100 -0.177000 -2.06e-01 4.19e-03 8.74e-04
Removal-of-the-Flap-Intermediate-from-the-C-strand 10 3.66e-01 5.78e-01 0.27100 0.166000 -2.14e-01 3.63e-01 2.41e-01
Mitochondrial-protein-import 56 2.51e-03 1.87e-02 0.27000 -0.267000 4.19e-02 5.50e-04 5.88e-01
Platelet-degranulation 93 1.03e-04 1.74e-03 0.26900 0.158000 -2.18e-01 8.38e-03 2.89e-04
Pink/Parkin-Mediated-Mitophagy 20 1.38e-01 3.35e-01 0.26900 -0.211000 1.67e-01 1.02e-01 1.97e-01
Semaphorin-interactions 51 4.10e-03 2.87e-02 0.26900 0.019100 -2.68e-01 8.14e-01 9.18e-04
Dopamine-Neurotransmitter-Release-Cycle 12 2.58e-01 4.85e-01 0.26900 0.265000 4.35e-02 1.11e-01 7.94e-01
Degradation-of-GLI1-by-the-proteasome 54 2.60e-03 1.93e-02 0.26900 -0.268000 -1.63e-02 6.57e-04 8.36e-01
Mitochondrial-biogenesis 71 9.67e-04 9.47e-03 0.26800 -0.184000 1.96e-01 7.56e-03 4.36e-03
SHC-mediated-cascade:FGFR2 10 3.52e-01 5.66e-01 0.26800 -0.055400 2.62e-01 7.62e-01 1.51e-01
SHC-mediated-cascade:FGFR4 10 3.52e-01 5.66e-01 0.26800 -0.055400 2.62e-01 7.62e-01 1.51e-01
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport 149 3.11e-07 1.20e-05 0.26800 -0.253000 8.78e-02 1.08e-07 6.50e-02
ABC-transporter-disorders 65 1.19e-03 1.09e-02 0.26700 -0.262000 5.36e-02 2.64e-04 4.56e-01
Autodegradation-of-Cdh1-by-Cdh1:APC/C 60 1.22e-03 1.10e-02 0.26700 -0.262000 -5.24e-02 4.53e-04 4.83e-01
Downstream-signaling-of-activated-FGFR3 18 1.74e-01 3.81e-01 0.26700 -0.163000 2.11e-01 2.32e-01 1.20e-01
GPVI-mediated-activation-cascade 26 5.04e-02 1.76e-01 0.26600 -0.243000 -1.08e-01 3.21e-02 3.39e-01
APC/C:Cdh1-mediated-degradation-of-Cdc20-and-other-APC/C:Cdh1-targeted-proteins-in-late-mitosis/early-G1 62 1.12e-03 1.05e-02 0.26600 -0.263000 -3.77e-02 3.44e-04 6.08e-01
Mitochondrial-translation-initiation 88 3.67e-05 7.81e-04 0.26600 -0.149000 -2.20e-01 1.61e-02 3.65e-04
Signaling-by-PDGFRA-extracellular-domain-mutants 12 2.46e-01 4.78e-01 0.26500 0.173000 2.01e-01 2.98e-01 2.29e-01
Signaling-by-PDGFRA-transmembrane,-juxtamembrane-and-kinase-domain-mutants 12 2.46e-01 4.78e-01 0.26500 0.173000 2.01e-01 2.98e-01 2.29e-01
APC/C:Cdc20-mediated-degradation-of-Securin 61 1.23e-03 1.10e-02 0.26500 -0.261000 -4.85e-02 4.33e-04 5.13e-01
Interleukin-12-signaling 36 3.19e-02 1.30e-01 0.26500 0.179000 -1.95e-01 6.30e-02 4.25e-02
Cytosolic-iron-sulfur-cluster-assembly 10 3.36e-01 5.61e-01 0.26500 -0.033100 -2.63e-01 8.56e-01 1.50e-01
Adenylate-cyclase-inhibitory-pathway 10 3.53e-01 5.67e-01 0.26500 0.263000 -2.38e-02 1.49e-01 8.96e-01
Membrane-binding-and-targetting-of-GAG-proteins 11 2.85e-01 5.13e-01 0.26400 -0.233000 -1.24e-01 1.81e-01 4.77e-01
Synthesis-And-Processing-Of-GAG,-GAGPOL-Polyproteins 11 2.85e-01 5.13e-01 0.26400 -0.233000 -1.24e-01 1.81e-01 4.77e-01
EPHB-mediated-forward-signaling 28 6.03e-02 2.00e-01 0.26300 0.059200 -2.57e-01 5.88e-01 1.88e-02
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers 23 7.83e-02 2.42e-01 0.26300 -0.080200 -2.51e-01 5.06e-01 3.76e-02
ATF6-(ATF6-alpha)-activates-chaperone-genes 10 3.49e-01 5.65e-01 0.26300 -0.007050 -2.63e-01 9.69e-01 1.50e-01
Interleukin-6-family-signaling 16 1.59e-01 3.64e-01 0.26300 0.192000 1.80e-01 1.84e-01 2.13e-01
Aggrephagy 18 1.45e-01 3.47e-01 0.26300 -0.260000 -3.62e-02 5.60e-02 7.91e-01
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint 62 1.31e-03 1.13e-02 0.26200 -0.256000 -5.14e-02 4.85e-04 4.85e-01
Cdc20:Phospho-APC/C-mediated-degradation-of-Cyclin-A 62 1.31e-03 1.13e-02 0.26200 -0.256000 -5.14e-02 4.85e-04 4.85e-01
Removal-of-the-Flap-Intermediate 11 3.35e-01 5.61e-01 0.26100 0.048800 -2.56e-01 7.79e-01 1.41e-01
mTOR-signalling 39 2.49e-02 1.08e-01 0.26100 -0.113000 2.35e-01 2.22e-01 1.12e-02
FRS-mediated-FGFR1-signaling 12 3.22e-01 5.52e-01 0.26000 -0.116000 2.33e-01 4.88e-01 1.62e-01
CDK-mediated-phosphorylation-and-removal-of-Cdc6 62 1.46e-03 1.21e-02 0.26000 -0.257000 -4.12e-02 4.72e-04 5.75e-01
Transcription-of-E2F-targets-under-negative-control-by-p107-(RBL1)-and-p130-(RBL2)-in-complex-with-HDAC1 12 2.75e-01 5.03e-01 0.26000 0.250000 7.23e-02 1.35e-01 6.65e-01
Processive-synthesis-on-the-C-strand-of-the-telomere 11 3.61e-01 5.74e-01 0.26000 0.148000 -2.13e-01 3.95e-01 2.20e-01
Striated-Muscle-Contraction 25 8.84e-02 2.58e-01 0.25900 0.059300 -2.52e-01 6.08e-01 2.91e-02
NOD1/2-Signaling-Pathway 28 5.85e-02 1.98e-01 0.25900 0.259000 3.71e-03 1.79e-02 9.73e-01
Phase-0---rapid-depolarisation 24 9.97e-02 2.75e-01 0.25800 -0.065400 2.50e-01 5.79e-01 3.40e-02
Receptor-Mediated-Mitophagy 11 3.20e-01 5.50e-01 0.25800 0.038600 2.55e-01 8.24e-01 1.43e-01
Caspase-activation-via-extrinsic-apoptotic-signalling-pathway 21 1.48e-01 3.48e-01 0.25800 0.211000 -1.48e-01 9.37e-02 2.42e-01
Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism 11 3.59e-01 5.72e-01 0.25800 -0.105000 2.35e-01 5.45e-01 1.77e-01
Defects-in-cobalamin-(B12)-metabolism 11 3.59e-01 5.72e-01 0.25800 -0.105000 2.35e-01 5.45e-01 1.77e-01
G1/S-DNA-Damage-Checkpoints 57 2.11e-03 1.63e-02 0.25800 -0.231000 -1.14e-01 2.57e-03 1.37e-01
Translation 265 4.78e-13 3.47e-11 0.25700 -0.135000 -2.19e-01 1.74e-04 9.52e-10
APC/C:Cdc20-mediated-degradation-of-mitotic-proteins 63 1.46e-03 1.21e-02 0.25700 -0.252000 -5.28e-02 5.58e-04 4.70e-01
Activation-of-APC/C-and-APC/C:Cdc20-mediated-degradation-of-mitotic-proteins 63 1.46e-03 1.21e-02 0.25700 -0.252000 -5.28e-02 5.58e-04 4.70e-01
Sema4D-induced-cell-migration-and-growth-cone-collapse 18 1.75e-01 3.82e-01 0.25700 0.038500 -2.54e-01 7.77e-01 6.23e-02
RIPK1-mediated-regulated-necrosis 13 3.06e-01 5.37e-01 0.25700 0.124000 -2.25e-01 4.41e-01 1.61e-01
Regulated-Necrosis 13 3.06e-01 5.37e-01 0.25700 0.124000 -2.25e-01 4.41e-01 1.61e-01
N-glycan-antennae-elongation-in-the-medial/trans-Golgi 18 1.94e-01 4.08e-01 0.25600 0.229000 -1.15e-01 9.28e-02 4.00e-01
Regulation-of-Complement-cascade 19 1.32e-01 3.31e-01 0.25600 -0.107000 -2.32e-01 4.19e-01 7.99e-02
Processive-synthesis-on-the-lagging-strand 12 3.17e-01 5.48e-01 0.25600 0.042100 -2.52e-01 8.01e-01 1.30e-01
Activation-of-Matrix-Metalloproteinases 12 3.43e-01 5.64e-01 0.25500 0.153000 -2.05e-01 3.60e-01 2.19e-01
ER-Phagosome-pathway 69 6.65e-04 7.40e-03 0.25500 -0.225000 -1.19e-01 1.22e-03 8.75e-02
Meiotic-recombination 15 2.37e-01 4.68e-01 0.25500 0.253000 -2.90e-02 8.98e-02 8.46e-01
Cell-surface-interactions-at-the-vascular-wall 77 1.02e-03 9.73e-03 0.25400 0.114000 -2.27e-01 8.31e-02 5.85e-04
Mitochondrial-calcium-ion-transport 20 1.65e-01 3.70e-01 0.25300 -0.233000 1.00e-01 7.18e-02 4.37e-01
Degradation-of-GLI2-by-the-proteasome 55 5.04e-03 3.36e-02 0.25300 -0.253000 5.37e-03 1.18e-03 9.45e-01
Meiosis 35 4.47e-02 1.62e-01 0.25300 0.225000 -1.16e-01 2.14e-02 2.37e-01
Interaction-between-L1-and-Ankyrins 15 2.39e-01 4.71e-01 0.25300 -0.016300 2.52e-01 9.13e-01 9.11e-02
Response-to-elevated-platelet-cytosolic-Ca2+ 97 2.34e-04 3.14e-03 0.25200 0.148000 -2.03e-01 1.17e-02 5.53e-04
SCF(Skp2)-mediated-degradation-of-p27/p21 51 5.47e-03 3.61e-02 0.25200 -0.233000 -9.41e-02 3.98e-03 2.46e-01
Trafficking-of-GluR2-containing-AMPA-receptors 11 3.56e-01 5.70e-01 0.25100 -0.250000 2.36e-02 1.51e-01 8.92e-01
Signaling-by-Hippo 18 1.59e-01 3.64e-01 0.25100 0.231000 9.87e-02 9.00e-02 4.69e-01
NIK-->noncanonical-NF-kB-signaling 55 5.50e-03 3.61e-02 0.25100 -0.251000 6.65e-03 1.30e-03 9.32e-01
GLI3-is-processed-to-GLI3R-by-the-proteasome 55 5.91e-03 3.70e-02 0.25100 -0.250000 1.88e-02 1.36e-03 8.10e-01
Mitochondrial-translation 94 5.81e-05 1.12e-03 0.25000 -0.169000 -1.85e-01 4.68e-03 1.99e-03
Regulation-of-PTEN-mRNA-translation 11 3.97e-01 6.04e-01 0.24800 -0.187000 1.63e-01 2.83e-01 3.49e-01
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins. 103 4.30e-05 8.70e-04 0.24700 -0.230000 -8.90e-02 5.63e-05 1.19e-01
Response-of-Mtb-to-phagocytosis 21 1.23e-01 3.17e-01 0.24500 -0.192000 -1.52e-01 1.28e-01 2.27e-01
Cardiac-conduction 78 6.30e-04 7.11e-03 0.24500 0.057100 2.38e-01 3.84e-01 2.79e-04
G-alpha-(z)-signalling-events 30 8.76e-02 2.57e-01 0.24400 0.176000 -1.70e-01 9.62e-02 1.08e-01
FGFR2-alternative-splicing 24 1.14e-01 3.01e-01 0.24400 -0.007680 -2.44e-01 9.48e-01 3.89e-02
Uptake-and-actions-of-bacterial-toxins 22 1.68e-01 3.74e-01 0.24300 -0.144000 1.96e-01 2.43e-01 1.11e-01
Regulation-of-innate-immune-responses-to-cytosolic-DNA 11 3.38e-01 5.63e-01 0.24300 -0.168000 -1.76e-01 3.36e-01 3.11e-01
Asymmetric-localization-of-PCP-proteins 58 5.53e-03 3.61e-02 0.24300 -0.243000 -8.38e-03 1.40e-03 9.12e-01
Dectin-1-mediated-noncanonical-NF-kB-signaling 56 6.80e-03 4.13e-02 0.24300 -0.242000 -5.35e-03 1.71e-03 9.45e-01
Metabolism-of-porphyrins 18 1.93e-01 4.08e-01 0.24200 -0.240000 -3.20e-02 7.76e-02 8.14e-01
Regulation-of-IFNA-signaling 11 3.44e-01 5.64e-01 0.24200 -0.147000 -1.92e-01 3.99e-01 2.70e-01
Downstream-TCR-signaling 76 1.50e-03 1.23e-02 0.24100 -0.240000 2.81e-02 3.12e-04 6.72e-01
AMER1-mutants-destabilize-the-destruction-complex 14 2.59e-01 4.85e-01 0.24100 0.158000 1.82e-01 3.07e-01 2.38e-01
APC-truncation-mutants-have-impaired-AXIN-binding 14 2.59e-01 4.85e-01 0.24100 0.158000 1.82e-01 3.07e-01 2.38e-01
AXIN-missense-mutants-destabilize-the-destruction-complex 14 2.59e-01 4.85e-01 0.24100 0.158000 1.82e-01 3.07e-01 2.38e-01
AXIN-mutants-destabilize-the-destruction-complex,-activating-WNT-signaling 14 2.59e-01 4.85e-01 0.24100 0.158000 1.82e-01 3.07e-01 2.38e-01
Truncations-of-AMER1-destabilize-the-destruction-complex 14 2.59e-01 4.85e-01 0.24100 0.158000 1.82e-01 3.07e-01 2.38e-01
truncated-APC-mutants-destabilize-the-destruction-complex 14 2.59e-01 4.85e-01 0.24100 0.158000 1.82e-01 3.07e-01 2.38e-01
Synthesis-of-very-long-chain-fatty-acyl-CoAs 15 2.79e-01 5.08e-01 0.24100 0.238000 -3.75e-02 1.11e-01 8.02e-01
Sema4D-in-semaphorin-signaling 21 1.88e-01 4.01e-01 0.24100 0.130000 -2.03e-01 3.04e-01 1.08e-01
Glutamate-Neurotransmitter-Release-Cycle 12 3.70e-01 5.82e-01 0.24100 0.230000 -6.95e-02 1.67e-01 6.77e-01
Telomere-Extension-By-Telomerase 14 2.60e-01 4.87e-01 0.24000 -0.171000 -1.69e-01 2.68e-01 2.74e-01
NR1H3-&-NR1H2-regulate-gene-expression-linked-to-cholesterol-transport-and-efflux 30 9.50e-02 2.67e-01 0.24000 -0.160000 1.79e-01 1.29e-01 9.04e-02
G0-and-Early-G1 18 1.91e-01 4.05e-01 0.23900 0.222000 8.79e-02 1.03e-01 5.19e-01
Downstream-signaling-events-of-B-Cell-Receptor-(BCR) 73 1.53e-03 1.24e-02 0.23800 -0.234000 -4.50e-02 5.50e-04 5.07e-01
Myogenesis 22 1.59e-01 3.64e-01 0.23800 -0.030600 2.36e-01 8.04e-01 5.52e-02
Activation-of-NF-kappaB-in-B-cells 60 5.82e-03 3.69e-02 0.23800 -0.238000 -6.45e-03 1.46e-03 9.31e-01
Bile-acid-and-bile-salt-metabolism 20 1.88e-01 4.01e-01 0.23800 -0.029700 2.36e-01 8.18e-01 6.78e-02
Signaling-by-FGFR1-in-disease 31 6.90e-02 2.20e-01 0.23800 0.010700 2.38e-01 9.18e-01 2.21e-02
Regulation-of-gene-expression-in-late-stage-(branching-morphogenesis)-pancreatic-bud-precursor-cells 12 3.96e-01 6.03e-01 0.23800 -0.142000 1.90e-01 3.95e-01 2.53e-01
RNA-Polymerase-I-Transcription-Termination 30 6.09e-02 2.01e-01 0.23700 -0.164000 -1.70e-01 1.19e-01 1.06e-01
mRNA-decay-by-5'-to-3'-exoribonuclease 15 2.55e-01 4.85e-01 0.23700 -0.214000 -9.98e-02 1.51e-01 5.03e-01
PIWI-interacting-RNA-(piRNA)-biogenesis 15 2.49e-01 4.81e-01 0.23600 -0.141000 -1.90e-01 3.44e-01 2.03e-01
Regulation-of-necroptotic-cell-death 11 4.29e-01 6.30e-01 0.23600 0.201000 -1.25e-01 2.49e-01 4.73e-01
FCERI-mediated-NF-kB-activation 70 2.73e-03 2.01e-02 0.23600 -0.236000 -6.66e-03 6.54e-04 9.23e-01
COPI-independent-Golgi-to-ER-retrograde-traffic 30 7.29e-02 2.30e-01 0.23600 0.046500 2.31e-01 6.59e-01 2.85e-02
Olfactory-Signaling-Pathway 10 4.28e-01 6.30e-01 0.23500 -0.021000 -2.34e-01 9.08e-01 2.01e-01
Glycogen-synthesis 13 3.63e-01 5.75e-01 0.23400 -0.222000 7.63e-02 1.67e-01 6.34e-01
Regulation-of-MECP2-expression-and-activity 26 1.29e-01 3.26e-01 0.23400 -0.056900 2.27e-01 6.16e-01 4.52e-02
DNA-Replication-Pre-Initiation 68 2.43e-03 1.83e-02 0.23400 -0.213000 -9.58e-02 2.38e-03 1.73e-01
Circadian-Clock 63 5.93e-03 3.70e-02 0.23400 -0.012300 2.33e-01 8.66e-01 1.38e-03
Tristetraprolin-(TTP,-ZFP36)-binds-and-destabilizes-mRNA 16 2.53e-01 4.85e-01 0.23400 -0.048000 -2.29e-01 7.40e-01 1.14e-01
Resolution-of-D-loop-Structures-through-Synthesis-Dependent-Strand-Annealing-(SDSA) 13 3.50e-01 5.65e-01 0.23300 0.232000 -2.56e-02 1.48e-01 8.73e-01
Fanconi-Anemia-Pathway 27 9.92e-02 2.75e-01 0.23300 -0.229000 -4.60e-02 3.96e-02 6.79e-01
Energy-dependent-regulation-of-mTOR-by-LKB1-AMPK 28 1.20e-01 3.12e-01 0.23300 -0.102000 2.09e-01 3.50e-01 5.52e-02
Fatty-acid-metabolism 118 3.89e-05 8.14e-04 0.23300 0.072900 2.21e-01 1.72e-01 3.52e-05
Mitophagy 27 1.37e-01 3.34e-01 0.23200 -0.162000 1.67e-01 1.46e-01 1.34e-01
Nuclear-Receptor-transcription-pathway 38 5.63e-02 1.91e-01 0.23200 -0.090400 2.14e-01 3.35e-01 2.25e-02
Beta-catenin-phosphorylation-cascade 16 2.51e-01 4.83e-01 0.23200 0.069900 2.22e-01 6.28e-01 1.25e-01
Orc1-removal-from-chromatin 61 4.84e-03 3.28e-02 0.23200 -0.212000 -9.42e-02 4.17e-03 2.04e-01
IRS-mediated-signalling 29 1.11e-01 2.97e-01 0.23200 -0.086600 2.15e-01 4.20e-01 4.47e-02
Synthesis-of-bile-acids-and-bile-salts 19 2.27e-01 4.53e-01 0.23200 -0.050200 2.26e-01 7.05e-01 8.76e-02
Reproduction 40 5.28e-02 1.82e-01 0.23000 0.208000 -9.67e-02 2.28e-02 2.90e-01
Signaling-by-ERBB2-TMD/JMD-mutants 18 2.61e-01 4.87e-01 0.22900 0.216000 -7.64e-02 1.12e-01 5.75e-01
Extracellular-matrix-organization 185 4.40e-07 1.64e-05 0.22900 -0.015700 -2.28e-01 7.14e-01 9.58e-08
E3-ubiquitin-ligases-ubiquitinate-target-proteins 40 4.90e-02 1.73e-01 0.22800 -0.047800 2.23e-01 6.01e-01 1.47e-02
TCR-signaling 88 1.05e-03 9.90e-03 0.22800 -0.228000 4.68e-03 2.23e-04 9.40e-01
PKMTs-methylate-histone-lysines 40 5.92e-02 1.98e-01 0.22800 -0.165000 1.57e-01 7.11e-02 8.53e-02
RNA-Polymerase-III-Transcription-Termination 23 1.56e-01 3.62e-01 0.22700 -0.224000 -3.83e-02 6.30e-02 7.50e-01
Interleukin-12-family-signaling 41 5.64e-02 1.91e-01 0.22700 0.165000 -1.56e-01 6.76e-02 8.41e-02
Chaperone-Mediated-Autophagy 16 2.66e-01 4.90e-01 0.22600 -0.209000 -8.69e-02 1.49e-01 5.47e-01
Glutathione-conjugation 24 1.34e-01 3.31e-01 0.22500 0.116000 1.93e-01 3.26e-01 1.01e-01
Signaling-by-NOTCH4 78 1.62e-03 1.29e-02 0.22500 -0.204000 -9.52e-02 1.83e-03 1.47e-01
Polymerase-switching-on-the-C-strand-of-the-telomere 12 3.85e-01 5.95e-01 0.22500 -0.041200 -2.21e-01 8.05e-01 1.84e-01
Regulation-of-APC/C-activators-between-G1/S-and-early-anaphase 67 5.80e-03 3.69e-02 0.22500 -0.225000 -6.61e-03 1.46e-03 9.26e-01
Signaling-by-Retinoic-Acid 31 8.50e-02 2.53e-01 0.22500 0.044500 2.21e-01 6.68e-01 3.36e-02
Processing-of-SMDT1 14 3.62e-01 5.75e-01 0.22500 -0.217000 6.11e-02 1.61e-01 6.92e-01
Listeria-monocytogenes-entry-into-host-cells 14 3.63e-01 5.75e-01 0.22500 -0.216000 6.41e-02 1.63e-01 6.78e-01
VxPx-cargo-targeting-to-cilium 16 3.26e-01 5.55e-01 0.22400 -0.090200 2.05e-01 5.32e-01 1.57e-01
Abortive-elongation-of-HIV-1-transcript-in-the-absence-of-Tat 23 1.57e-01 3.62e-01 0.22300 -0.087500 -2.05e-01 4.68e-01 8.87e-02
Mitochondrial-iron-sulfur-cluster-biogenesis 12 3.77e-01 5.89e-01 0.22300 -0.101000 -1.99e-01 5.46e-01 2.33e-01
Cytochrome-c-mediated-apoptotic-response 11 4.28e-01 6.30e-01 0.22200 0.220000 3.57e-02 2.08e-01 8.37e-01
B-WICH-complex-positively-regulates-rRNA-expression 31 8.52e-02 2.53e-01 0.22200 -0.208000 -7.72e-02 4.48e-02 4.57e-01
Selective-autophagy 56 2.42e-02 1.06e-01 0.22100 -0.173000 1.37e-01 2.53e-02 7.57e-02
Plasma-lipoprotein-remodeling 13 3.96e-01 6.03e-01 0.22000 -0.218000 3.30e-02 1.74e-01 8.37e-01
NR1H2-and-NR1H3-mediated-signaling 35 8.43e-02 2.53e-01 0.22000 -0.039500 2.17e-01 6.86e-01 2.67e-02
Signaling-by-the-B-Cell-Receptor-(BCR) 95 6.05e-04 6.98e-03 0.22000 -0.203000 -8.59e-02 6.60e-04 1.48e-01
Phospholipid-metabolism 162 2.73e-06 8.88e-05 0.22000 0.125000 1.81e-01 6.39e-03 7.23e-05
Transcriptional-regulation-by-RUNX3 87 1.59e-03 1.28e-02 0.21900 -0.218000 -2.46e-02 4.46e-04 6.92e-01
VEGFR2-mediated-vascular-permeability 24 1.75e-01 3.82e-01 0.21900 -0.219000 1.43e-03 6.30e-02 9.90e-01
Synthesis-of-bile-acids-and-bile-salts-via-7alpha-hydroxycholesterol 11 4.72e-01 6.63e-01 0.21900 -0.071600 2.07e-01 6.81e-01 2.34e-01
Defective-EXT1-causes-exostoses-1,-TRPS2-and-CHDS 12 4.02e-01 6.06e-01 0.21900 -0.055200 -2.12e-01 7.41e-01 2.04e-01
Defective-EXT2-causes-exostoses-2 12 4.02e-01 6.06e-01 0.21900 -0.055200 -2.12e-01 7.41e-01 2.04e-01
MicroRNA-(miRNA)-biogenesis 24 1.51e-01 3.52e-01 0.21900 -0.183000 -1.19e-01 1.21e-01 3.12e-01
G-protein-mediated-events 43 3.32e-02 1.33e-01 0.21800 0.166000 1.42e-01 6.01e-02 1.07e-01
PLC-beta-mediated-events 43 3.32e-02 1.33e-01 0.21800 0.166000 1.42e-01 6.01e-02 1.07e-01
Peptide-ligand-binding-receptors 36 6.48e-02 2.10e-01 0.21800 -0.064200 -2.09e-01 5.06e-01 3.04e-02
Methylation 11 4.40e-01 6.40e-01 0.21800 0.045200 2.13e-01 7.95e-01 2.21e-01
MAPK-targets/-Nuclear-events-mediated-by-MAP-kinases 30 1.29e-01 3.26e-01 0.21700 -0.047300 2.12e-01 6.54e-01 4.44e-02
Signaling-by-NOTCH2 27 1.23e-01 3.17e-01 0.21600 -0.176000 -1.26e-01 1.14e-01 2.57e-01
Regulation-of-IFNG-signaling 12 4.09e-01 6.12e-01 0.21600 0.061100 2.07e-01 7.14e-01 2.14e-01
RUNX1-regulates-genes-involved-in-megakaryocyte-differentiation-and-platelet-function 34 9.94e-02 2.75e-01 0.21600 -0.212000 3.92e-02 3.23e-02 6.92e-01
p38MAPK-events 12 4.62e-01 6.57e-01 0.21600 0.109000 -1.86e-01 5.14e-01 2.64e-01
Triglyceride-catabolism 14 3.64e-01 5.76e-01 0.21600 0.214000 2.70e-02 1.66e-01 8.61e-01
Protein-localization 141 1.46e-04 2.17e-03 0.21500 -0.146000 1.58e-01 2.84e-03 1.19e-03
Ras-activation-upon-Ca2+-influx-through-NMDA-receptor 13 4.20e-01 6.24e-01 0.21500 -0.208000 5.43e-02 1.93e-01 7.35e-01
Negative-regulation-of-FGFR2-signaling 20 2.72e-01 4.99e-01 0.21500 -0.085900 1.98e-01 5.06e-01 1.26e-01
Negative-regulation-of-FGFR4-signaling 20 2.72e-01 4.99e-01 0.21500 -0.085900 1.98e-01 5.06e-01 1.26e-01
Pre-NOTCH-Transcription-and-Translation 31 1.05e-01 2.86e-01 0.21500 -0.210000 -4.53e-02 4.29e-02 6.62e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-Cytochrome-C-Release 13 4.42e-01 6.41e-01 0.21500 0.165000 -1.37e-01 3.02e-01 3.93e-01
Platelet-activation,-signaling-and-aggregation 187 8.29e-06 2.18e-04 0.21400 0.098400 -1.90e-01 2.08e-02 8.26e-06
Lagging-Strand-Synthesis 16 3.50e-01 5.65e-01 0.21300 0.047700 -2.08e-01 7.41e-01 1.51e-01
Signalling-to-RAS 17 3.44e-01 5.64e-01 0.21300 0.185000 -1.06e-01 1.88e-01 4.49e-01
Cyclin-A/B1/B2-associated-events-during-G2/M-transition 17 2.94e-01 5.23e-01 0.21300 -0.055500 -2.06e-01 6.92e-01 1.42e-01
MAP-kinase-activation 60 1.72e-02 8.28e-02 0.21300 -0.006660 2.12e-01 9.29e-01 4.47e-03
Assembly-and-cell-surface-presentation-of-NMDA-receptors 14 4.23e-01 6.26e-01 0.21200 -0.140000 1.60e-01 3.65e-01 3.00e-01
mTORC1-mediated-signalling 22 2.48e-01 4.81e-01 0.21200 -0.081800 1.96e-01 5.07e-01 1.12e-01
Non-integrin-membrane-ECM-interactions 36 6.80e-02 2.17e-01 0.21200 -0.167000 -1.31e-01 8.26e-02 1.75e-01
HCMV-Early-Events 54 3.54e-02 1.39e-01 0.21200 -0.111000 1.81e-01 1.58e-01 2.17e-02
Diseases-associated-with-glycosylation-precursor-biosynthesis 17 3.46e-01 5.65e-01 0.21200 0.094500 -1.89e-01 5.00e-01 1.77e-01
Deactivation-of-the-beta-catenin-transactivating-complex 33 8.73e-02 2.57e-01 0.21100 -0.166000 -1.31e-01 9.93e-02 1.94e-01
p130Cas-linkage-to-MAPK-signaling-for-integrins 12 4.76e-01 6.67e-01 0.21100 0.187000 -9.83e-02 2.63e-01 5.56e-01
activated-TAK1-mediates-p38-MAPK-activation 18 2.88e-01 5.16e-01 0.21100 0.028800 2.09e-01 8.32e-01 1.25e-01
COPI-dependent-Golgi-to-ER-retrograde-traffic 58 2.02e-02 9.34e-02 0.21100 0.211000 2.43e-03 5.50e-03 9.75e-01
Tight-junction-interactions 10 5.40e-01 7.17e-01 0.21100 0.105000 -1.83e-01 5.66e-01 3.16e-01
Potassium-Channels 40 5.34e-02 1.83e-01 0.21100 0.123000 1.71e-01 1.78e-01 6.19e-02
HS-GAG-degradation 17 3.41e-01 5.64e-01 0.21000 0.052300 -2.03e-01 7.09e-01 1.47e-01
Cell-junction-organization 49 3.18e-02 1.30e-01 0.21000 -0.197000 -7.01e-02 1.69e-02 3.96e-01
Nicotinamide-salvaging 13 4.04e-01 6.07e-01 0.20900 -0.201000 -5.79e-02 2.10e-01 7.18e-01
Synthesis,-secretion,-and-deacylation-of-Ghrelin 11 5.23e-01 7.05e-01 0.20800 0.133000 -1.60e-01 4.45e-01 3.59e-01
Synthesis-of-IP3-and-IP4-in-the-cytosol 21 2.91e-01 5.21e-01 0.20800 0.150000 -1.44e-01 2.34e-01 2.55e-01
Regulation-of-signaling-by-CBL 16 3.81e-01 5.90e-01 0.20700 -0.191000 8.09e-02 1.87e-01 5.75e-01
RNA-Polymerase-III-Chain-Elongation 18 2.77e-01 5.04e-01 0.20700 -0.138000 -1.54e-01 3.10e-01 2.57e-01
Growth-hormone-receptor-signaling 18 3.48e-01 5.65e-01 0.20700 -0.127000 1.63e-01 3.49e-01 2.31e-01
Cohesin-Loading-onto-Chromatin 10 4.91e-01 6.83e-01 0.20700 0.151000 1.41e-01 4.09e-01 4.40e-01
Mitotic-Telophase/Cytokinesis 10 4.91e-01 6.83e-01 0.20700 0.151000 1.41e-01 4.09e-01 4.40e-01
Antigen-processing-Cross-presentation 80 3.85e-03 2.73e-02 0.20600 -0.182000 -9.68e-02 4.86e-03 1.35e-01
Diseases-associated-with-O-glycosylation-of-proteins 39 9.33e-02 2.65e-01 0.20600 0.059500 -1.98e-01 5.21e-01 3.27e-02
Transcriptional-regulation-of-pluripotent-stem-cells 14 4.04e-01 6.07e-01 0.20600 0.006220 2.06e-01 9.68e-01 1.82e-01
Class-A/1-(Rhodopsin-like-receptors) 62 1.29e-02 6.73e-02 0.20600 -0.154000 -1.36e-01 3.57e-02 6.41e-02
RUNX3-regulates-NOTCH-signaling 13 4.69e-01 6.61e-01 0.20600 -0.174000 1.10e-01 2.78e-01 4.93e-01
SUMOylation-of-intracellular-receptors 22 2.63e-01 4.89e-01 0.20600 -0.054900 1.98e-01 6.56e-01 1.08e-01
Opioid-Signalling 70 8.88e-03 5.12e-02 0.20500 0.194000 6.68e-02 5.00e-03 3.35e-01
APC/C-mediated-degradation-of-cell-cycle-proteins 69 1.14e-02 6.20e-02 0.20500 -0.204000 -2.05e-02 3.36e-03 7.69e-01
Regulation-of-mitotic-cell-cycle 69 1.14e-02 6.20e-02 0.20500 -0.204000 -2.05e-02 3.36e-03 7.69e-01
FGFR2-mutant-receptor-activation 20 2.59e-01 4.85e-01 0.20500 -0.193000 -6.83e-02 1.34e-01 5.97e-01
Deposition-of-new-CENPA-containing-nucleosomes-at-the-centromere 13 4.08e-01 6.11e-01 0.20400 0.144000 1.44e-01 3.70e-01 3.68e-01
Nucleosome-assembly 13 4.08e-01 6.11e-01 0.20400 0.144000 1.44e-01 3.70e-01 3.68e-01
Competing-endogenous-RNAs-(ceRNAs)-regulate-PTEN-translation 10 5.67e-01 7.31e-01 0.20400 -0.123000 1.62e-01 5.00e-01 3.75e-01
Synthesis-of-IP2,-IP,-and-Ins-in-the-cytosol 12 4.77e-01 6.68e-01 0.20400 -0.017300 2.03e-01 9.17e-01 2.24e-01
RAF-independent-MAPK1/3-activation 18 3.48e-01 5.65e-01 0.20300 -0.193000 6.28e-02 1.56e-01 6.45e-01
TNFR2-non-canonical-NF-kB-pathway 68 1.16e-02 6.29e-02 0.20300 -0.194000 -5.94e-02 5.71e-03 3.98e-01
Disorders-of-developmental-biology 10 5.70e-01 7.31e-01 0.20300 -0.120000 1.64e-01 5.12e-01 3.71e-01
Loss-of-function-of-MECP2-in-Rett-syndrome 10 5.70e-01 7.31e-01 0.20300 -0.120000 1.64e-01 5.12e-01 3.71e-01
Pervasive-developmental-disorders 10 5.70e-01 7.31e-01 0.20300 -0.120000 1.64e-01 5.12e-01 3.71e-01
RNA-Polymerase-I-Promoter-Escape 30 1.31e-01 3.28e-01 0.20300 -0.166000 -1.16e-01 1.15e-01 2.73e-01
Interleukin-20-family-signaling 13 4.45e-01 6.44e-01 0.20300 0.004730 2.02e-01 9.76e-01 2.06e-01
VEGFR2-mediated-cell-proliferation 17 3.42e-01 5.64e-01 0.20200 -0.019600 -2.02e-01 8.89e-01 1.50e-01
Processing-of-Capped-Intronless-Pre-mRNA 24 1.97e-01 4.11e-01 0.20200 -0.148000 -1.37e-01 2.10e-01 2.45e-01
Host-Interactions-of-HIV-factors 111 1.02e-03 9.73e-03 0.20100 -0.201000 -1.91e-02 2.69e-04 7.29e-01
tRNA-modification-in-the-nucleus-and-cytosol 39 8.40e-02 2.53e-01 0.20100 -0.196000 -4.48e-02 3.46e-02 6.29e-01
Polo-like-kinase-mediated-events 10 5.73e-01 7.34e-01 0.20000 -0.088600 1.79e-01 6.28e-01 3.27e-01
Nucleotide-binding-domain,-leucine-rich-repeat-containing-receptor-(NLR)-signaling-pathways 40 9.43e-02 2.67e-01 0.20000 0.199000 -2.04e-02 2.98e-02 8.24e-01
Signaling-by-FGFR2-IIIa-TM 18 3.06e-01 5.38e-01 0.19900 -0.125000 -1.54e-01 3.57e-01 2.57e-01
Misspliced-GSK3beta-mutants-stabilize-beta-catenin 15 3.80e-01 5.89e-01 0.19900 0.085200 1.80e-01 5.68e-01 2.28e-01
S33-mutants-of-beta-catenin-aren't-phosphorylated 15 3.80e-01 5.89e-01 0.19900 0.085200 1.80e-01 5.68e-01 2.28e-01
S37-mutants-of-beta-catenin-aren't-phosphorylated 15 3.80e-01 5.89e-01 0.19900 0.085200 1.80e-01 5.68e-01 2.28e-01
S45-mutants-of-beta-catenin-aren't-phosphorylated 15 3.80e-01 5.89e-01 0.19900 0.085200 1.80e-01 5.68e-01 2.28e-01
T41-mutants-of-beta-catenin-aren't-phosphorylated 15 3.80e-01 5.89e-01 0.19900 0.085200 1.80e-01 5.68e-01 2.28e-01
phosphorylation-site-mutants-of-CTNNB1-are-not-targeted-to-the-proteasome-by-the-destruction-complex 15 3.80e-01 5.89e-01 0.19900 0.085200 1.80e-01 5.68e-01 2.28e-01
Neddylation 201 2.12e-05 4.94e-04 0.19900 -0.109000 1.66e-01 7.92e-03 5.13e-05
HCMV-Infection 75 1.82e-02 8.66e-02 0.19800 -0.115000 1.61e-01 8.57e-02 1.60e-02
Axon-guidance 394 2.19e-11 1.08e-09 0.19800 -0.100000 -1.70e-01 7.02e-04 8.43e-09
Triglyceride-metabolism 22 2.40e-01 4.71e-01 0.19800 0.151000 1.27e-01 2.19e-01 3.02e-01
ISG15-antiviral-mechanism 61 3.35e-02 1.33e-01 0.19700 -0.191000 5.09e-02 1.01e-02 4.93e-01
The-role-of-Nef-in-HIV-1-replication-and-disease-pathogenesis 21 2.82e-01 5.09e-01 0.19700 -0.195000 -2.65e-02 1.21e-01 8.33e-01
Antiviral-mechanism-by-IFN-stimulated-genes 66 2.32e-02 1.03e-01 0.19700 -0.195000 2.56e-02 6.10e-03 7.19e-01
Antigen-processing:-Ubiquitination-&-Proteasome-degradation 262 8.11e-07 2.86e-05 0.19700 -0.074800 1.82e-01 3.80e-02 4.29e-07
RUNX2-regulates-osteoblast-differentiation 19 3.25e-01 5.54e-01 0.19700 0.197000 7.92e-03 1.38e-01 9.52e-01
Interleukin-17-signaling 62 2.63e-02 1.13e-01 0.19700 0.003940 1.97e-01 9.57e-01 7.39e-03
Degradation-of-the-extracellular-matrix 54 3.57e-02 1.40e-01 0.19600 -0.064800 -1.85e-01 4.10e-01 1.87e-02
Glutamate-binding,-activation-of-AMPA-receptors-and-synaptic-plasticity 20 3.43e-01 5.64e-01 0.19600 -0.177000 8.42e-02 1.71e-01 5.15e-01
Trafficking-of-AMPA-receptors 20 3.43e-01 5.64e-01 0.19600 -0.177000 8.42e-02 1.71e-01 5.15e-01
PI3K/AKT-Signaling-in-Cancer 66 3.29e-02 1.33e-01 0.19500 -0.143000 1.33e-01 4.44e-02 6.26e-02
Peptide-hormone-metabolism 48 7.41e-02 2.32e-01 0.19500 0.187000 -5.52e-02 2.52e-02 5.08e-01
Rap1-signalling 13 4.64e-01 6.58e-01 0.19500 -0.193000 -2.87e-02 2.29e-01 8.58e-01
Insulin-receptor-signalling-cascade 34 1.61e-01 3.69e-01 0.19500 -0.065600 1.83e-01 5.08e-01 6.45e-02
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain 18 3.94e-01 6.01e-01 0.19500 0.118000 -1.55e-01 3.88e-01 2.55e-01
InlB-mediated-entry-of-Listeria-monocytogenes-into-host-cell 11 5.48e-01 7.23e-01 0.19400 -0.190000 4.13e-02 2.76e-01 8.13e-01
Formation-of-the-Early-Elongation-Complex 33 1.46e-01 3.47e-01 0.19300 -0.040800 -1.88e-01 6.85e-01 6.14e-02
Formation-of-the-HIV-1-Early-Elongation-Complex 33 1.46e-01 3.47e-01 0.19300 -0.040800 -1.88e-01 6.85e-01 6.14e-02
Cytosolic-sulfonation-of-small-molecules 12 5.12e-01 6.98e-01 0.19200 0.002390 -1.92e-01 9.89e-01 2.49e-01
Estrogen-dependent-nuclear-events-downstream-of-ESR-membrane-signaling 19 3.84e-01 5.94e-01 0.19200 -0.129000 1.43e-01 3.31e-01 2.82e-01
Neurotransmitter-release-cycle 23 2.52e-01 4.84e-01 0.19200 0.174000 8.05e-02 1.48e-01 5.04e-01
Formation-of-Fibrin-Clot-(Clotting-Cascade) 14 4.55e-01 6.51e-01 0.19200 0.191000 1.13e-02 2.15e-01 9.42e-01
MAP3K8-(TPL2)-dependent-MAPK1/3-activation 15 4.23e-01 6.26e-01 0.19100 0.038500 1.87e-01 7.97e-01 2.10e-01
G-alpha-(s)-signalling-events 67 3.59e-02 1.40e-01 0.19100 0.112000 -1.54e-01 1.13e-01 2.90e-02
Termination-of-translesion-DNA-synthesis 27 2.06e-01 4.21e-01 0.19100 -0.067700 -1.78e-01 5.43e-01 1.09e-01
Disassembly-of-the-destruction-complex-and-recruitment-of-AXIN-to-the-membrane 26 2.27e-01 4.53e-01 0.18900 0.050600 1.83e-01 6.55e-01 1.07e-01
MyD88-cascade-initiated-on-plasma-membrane 74 1.71e-02 8.23e-02 0.18900 0.018100 1.88e-01 7.88e-01 5.11e-03
Toll-Like-Receptor-10-(TLR10)-Cascade 74 1.71e-02 8.23e-02 0.18900 0.018100 1.88e-01 7.88e-01 5.11e-03
Toll-Like-Receptor-5-(TLR5)-Cascade 74 1.71e-02 8.23e-02 0.18900 0.018100 1.88e-01 7.88e-01 5.11e-03
Transcriptional-regulation-by-the-AP-2-(TFAP2)-family-of-transcription-factors 23 2.62e-01 4.87e-01 0.18900 -0.081100 -1.71e-01 5.01e-01 1.56e-01
Class-I-peroxisomal-membrane-protein-import 18 4.01e-01 6.06e-01 0.18900 -0.058600 1.80e-01 6.67e-01 1.87e-01
Autophagy 117 3.70e-03 2.64e-02 0.18800 -0.127000 1.39e-01 1.78e-02 9.70e-03
Translocation-of-SLC2A4-(GLUT4)-to-the-plasma-membrane 49 5.87e-02 1.98e-01 0.18800 0.098400 1.60e-01 2.34e-01 5.32e-02
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs) 68 3.90e-02 1.47e-01 0.18700 0.122000 -1.42e-01 8.25e-02 4.26e-02
DARPP-32-events 22 2.81e-01 5.08e-01 0.18700 0.095100 1.61e-01 4.40e-01 1.90e-01
Nervous-system-development 408 1.77e-10 8.38e-09 0.18600 -0.087600 -1.64e-01 2.59e-03 1.58e-08
Frs2-mediated-activation 11 5.51e-01 7.23e-01 0.18600 -0.183000 -3.17e-02 2.92e-01 8.56e-01
Signaling-by-BMP 18 4.24e-01 6.28e-01 0.18600 -0.156000 1.02e-01 2.53e-01 4.53e-01
CREB1-phosphorylation-through-NMDA-receptor-mediated-activation-of-RAS-signaling 20 3.77e-01 5.89e-01 0.18600 -0.174000 6.47e-02 1.78e-01 6.17e-01
Pausing-and-recovery-of-Tat-mediated-HIV-elongation 27 2.22e-01 4.46e-01 0.18500 -0.083200 -1.65e-01 4.55e-01 1.38e-01
Tat-mediated-HIV-elongation-arrest-and-recovery 27 2.22e-01 4.46e-01 0.18500 -0.083200 -1.65e-01 4.55e-01 1.38e-01
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT) 27 2.75e-01 5.03e-01 0.18500 -0.170000 7.30e-02 1.28e-01 5.11e-01
mRNA-Splicing---Minor-Pathway 50 5.96e-02 1.99e-01 0.18400 -0.138000 -1.22e-01 9.17e-02 1.35e-01
TRAF6-mediated-induction-of-NFkB-and-MAP-kinases-upon-TLR7/8-or-9-activation 77 1.90e-02 8.98e-02 0.18400 0.005460 1.84e-01 9.34e-01 5.24e-03
Platelet-homeostasis 58 6.80e-02 2.17e-01 0.18400 0.104000 -1.52e-01 1.73e-01 4.53e-02
Transcriptional-Regulation-by-E2F6 27 2.19e-01 4.43e-01 0.18400 0.117000 1.42e-01 2.92e-01 2.02e-01
Amyloid-fiber-formation 31 1.81e-01 3.91e-01 0.18400 -0.079100 -1.66e-01 4.46e-01 1.10e-01
Macroautophagy 106 7.77e-03 4.59e-02 0.18400 -0.109000 1.48e-01 5.20e-02 8.82e-03
Hemostasis 373 4.84e-08 1.99e-06 0.18400 0.094400 -1.57e-01 1.88e-03 2.15e-07
RAB-geranylgeranylation 45 9.57e-02 2.68e-01 0.18400 0.023200 1.82e-01 7.88e-01 3.47e-02
HIV-elongation-arrest-and-recovery 29 1.97e-01 4.11e-01 0.18400 -0.127000 -1.32e-01 2.37e-01 2.17e-01
Pausing-and-recovery-of-HIV-elongation 29 1.97e-01 4.11e-01 0.18400 -0.127000 -1.32e-01 2.37e-01 2.17e-01
Ub-specific-processing-proteases 148 9.38e-04 9.26e-03 0.18300 -0.172000 6.39e-02 3.15e-04 1.81e-01
Apoptotic-factor-mediated-response 14 5.25e-01 7.07e-01 0.18300 0.152000 -1.01e-01 3.23e-01 5.12e-01
Transport-of-vitamins,-nucleosides,-and-related-molecules 25 2.91e-01 5.21e-01 0.18300 -0.022600 1.82e-01 8.45e-01 1.16e-01
Switching-of-origins-to-a-post-replicative-state 77 1.66e-02 8.18e-02 0.18300 -0.174000 -5.60e-02 8.39e-03 3.96e-01
Ca-dependent-events 31 2.00e-01 4.13e-01 0.18300 0.025900 1.81e-01 8.03e-01 8.15e-02
Class-B/2-(Secretin-family-receptors) 33 2.00e-01 4.13e-01 0.18100 0.180000 -1.93e-02 7.30e-02 8.48e-01
Synthesis-of-glycosylphosphatidylinositol-(GPI) 15 4.46e-01 6.44e-01 0.18100 0.088800 1.58e-01 5.52e-01 2.90e-01
EPH-Ephrin-signaling 70 3.13e-02 1.28e-01 0.18100 -0.001380 -1.81e-01 9.84e-01 8.88e-03
Signaling-by-Erythropoietin 23 3.30e-01 5.57e-01 0.18100 -0.179000 2.54e-02 1.37e-01 8.33e-01
PKA-activation 14 4.71e-01 6.63e-01 0.18000 0.140000 1.13e-01 3.64e-01 4.65e-01
Visual-phototransduction 40 1.35e-01 3.31e-01 0.18000 -0.021700 -1.79e-01 8.12e-01 5.08e-02
Signaling-by-NTRK3-(TRKC) 15 5.02e-01 6.90e-01 0.17900 0.171000 -5.39e-02 2.51e-01 7.18e-01
Anti-inflammatory-response-favouring-Leishmania-parasite-infection 68 4.39e-02 1.61e-01 0.17900 0.048600 -1.73e-01 4.89e-01 1.39e-02
Leishmania-parasite-growth-and-survival 68 4.39e-02 1.61e-01 0.17900 0.048600 -1.73e-01 4.89e-01 1.39e-02
Integrin-signaling 23 3.65e-01 5.77e-01 0.17900 0.129000 -1.25e-01 2.84e-01 3.01e-01
ER-Quality-Control-Compartment-(ERQC) 20 4.15e-01 6.18e-01 0.17900 -0.099900 1.49e-01 4.39e-01 2.50e-01
Toll-Like-Receptor-9-(TLR9)-Cascade 82 1.93e-02 9.09e-02 0.17900 0.002860 1.79e-01 9.64e-01 5.26e-03
NRIF-signals-cell-death-from-the-nucleus 14 5.02e-01 6.90e-01 0.17800 -0.026800 -1.76e-01 8.62e-01 2.55e-01
Metabolism-of-RNA 613 5.38e-14 5.10e-12 0.17700 -0.136000 -1.15e-01 1.47e-08 1.70e-06
Gastrin-CREB-signalling-pathway-via-PKC-and-MAPK 16 4.53e-01 6.49e-01 0.17700 -0.171000 -4.34e-02 2.35e-01 7.64e-01
Tie2-Signaling 15 4.62e-01 6.57e-01 0.17600 0.137000 1.10e-01 3.57e-01 4.60e-01
MET-activates-PTK2-signaling 13 5.15e-01 7.00e-01 0.17600 -0.148000 -9.45e-02 3.55e-01 5.55e-01
Signaling-by-high-kinase-activity-BRAF-mutants 29 2.94e-01 5.23e-01 0.17600 0.144000 -1.00e-01 1.79e-01 3.51e-01
Downstream-signaling-of-activated-FGFR1 18 4.58e-01 6.54e-01 0.17600 -0.064700 1.63e-01 6.35e-01 2.31e-01
PECAM1-interactions 11 5.98e-01 7.56e-01 0.17500 -0.003990 -1.75e-01 9.82e-01 3.14e-01
Signaling-by-ERBB2-in-Cancer 22 3.70e-01 5.82e-01 0.17500 0.174000 -2.32e-02 1.59e-01 8.51e-01
Golgi-to-ER-retrograde-transport 88 1.24e-02 6.57e-02 0.17500 0.155000 8.08e-02 1.19e-02 1.91e-01
Nicotinate-metabolism 22 3.32e-01 5.58e-01 0.17400 -0.142000 -1.01e-01 2.51e-01 4.11e-01
mRNA-Splicing---Major-Pathway 170 2.40e-04 3.19e-03 0.17300 -0.139000 -1.03e-01 1.79e-03 2.13e-02
Export-of-Viral-Ribonucleoproteins-from-Nucleus 29 2.99e-01 5.29e-01 0.17300 -0.157000 7.11e-02 1.43e-01 5.08e-01
Metabolism-of-water-soluble-vitamins-and-cofactors 92 1.27e-02 6.65e-02 0.17300 0.056200 1.63e-01 3.52e-01 6.95e-03
TRAF6-mediated-IRF7-activation 14 5.04e-01 6.91e-01 0.17200 -0.144000 -9.44e-02 3.52e-01 5.41e-01
G-alpha-(q)-signalling-events 92 2.23e-02 9.99e-02 0.17200 0.064100 -1.59e-01 2.89e-01 8.32e-03
Formation-of-HIV-1-elongation-complex-containing-HIV-1-Tat 39 1.63e-01 3.69e-01 0.17100 -0.046000 -1.65e-01 6.20e-01 7.52e-02
HIV-Transcription-Elongation 39 1.63e-01 3.69e-01 0.17100 -0.046000 -1.65e-01 6.20e-01 7.52e-02
Tat-mediated-elongation-of-the-HIV-1-transcript 39 1.63e-01 3.69e-01 0.17100 -0.046000 -1.65e-01 6.20e-01 7.52e-02
Chromatin-modifying-enzymes 188 6.34e-04 7.11e-03 0.17100 -0.111000 1.30e-01 9.10e-03 2.21e-03
Chromatin-organization 188 6.34e-04 7.11e-03 0.17100 -0.111000 1.30e-01 9.10e-03 2.21e-03
MAP2K-and-MAPK-activation 33 2.71e-01 4.97e-01 0.17100 0.114000 -1.27e-01 2.57e-01 2.08e-01
Synthesis-of-PIPs-at-the-early-endosome-membrane 16 4.65e-01 6.58e-01 0.17000 0.106000 1.33e-01 4.63e-01 3.58e-01
DNA-Damage/Telomere-Stress-Induced-Senescence 23 4.00e-01 6.06e-01 0.17000 0.148000 -8.30e-02 2.20e-01 4.91e-01
Interleukin-3,-Interleukin-5-and-GM-CSF-signaling 31 2.94e-01 5.24e-01 0.17000 -0.141000 9.49e-02 1.76e-01 3.61e-01
Interleukin-2-family-signaling 28 2.83e-01 5.11e-01 0.16900 0.032700 1.66e-01 7.65e-01 1.28e-01
Ca2+-pathway 48 1.10e-01 2.94e-01 0.16900 0.159000 5.73e-02 5.62e-02 4.93e-01
MyD88-dependent-cascade-initiated-on-endosome 78 3.51e-02 1.38e-01 0.16900 -0.004420 1.69e-01 9.46e-01 9.85e-03
Toll-Like-Receptor-7/8-(TLR7/8)-Cascade 78 3.51e-02 1.38e-01 0.16900 -0.004420 1.69e-01 9.46e-01 9.85e-03
Erythropoietin-activates-RAS 12 5.66e-01 7.31e-01 0.16900 -0.136000 -1.01e-01 4.16e-01 5.44e-01
Regulation-of-cholesterol-biosynthesis-by-SREBP-(SREBF) 51 9.29e-02 2.65e-01 0.16900 0.079300 1.49e-01 3.28e-01 6.57e-02
Processing-of-Intronless-Pre-mRNAs 17 4.46e-01 6.44e-01 0.16900 -0.117000 -1.22e-01 4.05e-01 3.84e-01
Cellular-response-to-heat-stress 90 2.97e-02 1.24e-01 0.16900 -0.145000 8.61e-02 1.75e-02 1.59e-01
Negative-regulation-of-FGFR3-signaling 21 4.38e-01 6.39e-01 0.16900 -0.085300 1.45e-01 4.99e-01 2.49e-01
Fatty-acyl-CoA-biosynthesis 25 3.44e-01 5.64e-01 0.16800 0.168000 -2.77e-03 1.45e-01 9.81e-01
Nonhomologous-End-Joining-(NHEJ) 29 2.70e-01 4.97e-01 0.16800 0.161000 4.76e-02 1.33e-01 6.57e-01
Diseases-of-glycosylation 102 1.71e-02 8.23e-02 0.16800 0.055200 -1.59e-01 3.36e-01 5.63e-03
Transport-of-Ribonucleoproteins-into-the-Host-Nucleus 28 3.29e-01 5.55e-01 0.16800 -0.061400 1.56e-01 5.74e-01 1.52e-01
SHC1-events-in-ERBB2-signaling 18 4.82e-01 6.73e-01 0.16800 0.162000 -4.28e-02 2.33e-01 7.53e-01
RNA-Polymerase-II-Transcription-Termination 60 6.10e-02 2.01e-01 0.16800 -0.110000 -1.27e-01 1.41e-01 9.00e-02
Positive-epigenetic-regulation-of-rRNA-expression 45 1.35e-01 3.31e-01 0.16800 -0.162000 -4.27e-02 6.01e-02 6.21e-01
TGF-beta-receptor-signaling-activates-SMADs 31 2.54e-01 4.85e-01 0.16700 -0.163000 -3.84e-02 1.17e-01 7.11e-01
NF-kB-activation-through-FADD/RIP-1-pathway-mediated-by-caspase-8-and--10 11 6.37e-01 7.87e-01 0.16700 0.165000 -2.49e-02 3.43e-01 8.86e-01
SHC-mediated-cascade:FGFR3 11 6.47e-01 7.94e-01 0.16700 -0.057100 1.57e-01 7.43e-01 3.67e-01
Synthesis-of-substrates-in-N-glycan-biosythesis 51 1.45e-01 3.47e-01 0.16700 0.122000 -1.14e-01 1.32e-01 1.59e-01
WNT-ligand-biogenesis-and-trafficking 11 6.31e-01 7.82e-01 0.16700 -0.004220 1.67e-01 9.81e-01 3.39e-01
Glucagon-signaling-in-metabolic-regulation 22 4.34e-01 6.34e-01 0.16700 0.132000 -1.01e-01 2.83e-01 4.11e-01
RA-biosynthesis-pathway 12 6.36e-01 7.87e-01 0.16700 0.120000 -1.15e-01 4.71e-01 4.90e-01
Synthesis-of-PIPs-at-the-plasma-membrane 51 1.04e-01 2.85e-01 0.16600 0.056000 1.57e-01 4.90e-01 5.30e-02
Glucose-metabolism 74 5.49e-02 1.88e-01 0.16600 -0.047900 1.59e-01 4.77e-01 1.82e-02
Extension-of-Telomeres 34 2.22e-01 4.46e-01 0.16600 -0.058600 -1.55e-01 5.55e-01 1.18e-01
Telomere-Maintenance 34 2.22e-01 4.46e-01 0.16600 -0.058600 -1.55e-01 5.55e-01 1.18e-01
Deubiquitination 211 3.63e-04 4.45e-03 0.16500 -0.150000 7.01e-02 1.89e-04 8.05e-02
Metabolism-of-steroids 94 1.44e-02 7.33e-02 0.16500 0.121000 1.13e-01 4.37e-02 5.92e-02
Hedgehog-'on'-state 75 3.79e-02 1.45e-01 0.16500 -0.155000 -5.76e-02 2.09e-02 3.89e-01
RORA-activates-gene-expression 17 5.33e-01 7.12e-01 0.16500 -0.120000 1.13e-01 3.91e-01 4.21e-01
Post-translational-protein-phosphorylation 63 9.86e-02 2.75e-01 0.16500 0.117000 -1.16e-01 1.09e-01 1.11e-01
Class-I-MHC-mediated-antigen-processing-&-presentation 307 1.08e-05 2.78e-04 0.16400 -0.057400 1.54e-01 8.55e-02 4.00e-06
Pentose-phosphate-pathway 10 6.88e-01 8.16e-01 0.16400 0.146000 -7.53e-02 4.25e-01 6.80e-01
Golgi-Associated-Vesicle-Biogenesis 50 1.39e-01 3.36e-01 0.16400 0.162000 -2.13e-02 4.71e-02 7.95e-01
ERK/MAPK-targets 21 4.64e-01 6.58e-01 0.16300 -0.098700 1.30e-01 4.34e-01 3.02e-01
PKA-mediated-phosphorylation-of-CREB 16 5.03e-01 6.91e-01 0.16300 0.053400 1.54e-01 7.11e-01 2.85e-01
Nuclear-Pore-Complex-(NPC)-Disassembly 29 3.48e-01 5.65e-01 0.16300 -0.086500 1.38e-01 4.20e-01 2.00e-01
Activation-of-the-pre-replicative-complex 22 4.50e-01 6.47e-01 0.16200 0.084700 -1.39e-01 4.92e-01 2.61e-01
Metabolism-of-lipids 518 3.62e-10 1.60e-08 0.16200 0.101000 1.27e-01 1.04e-04 8.99e-07
Formation-of-HIV-elongation-complex-in-the-absence-of-HIV-Tat 41 1.71e-01 3.76e-01 0.16200 -0.078800 -1.42e-01 3.83e-01 1.16e-01
Late-endosomal-microautophagy 26 3.51e-01 5.66e-01 0.16200 -0.161000 -1.36e-02 1.55e-01 9.04e-01
Formation-of-the-beta-catenin:TCF-transactivating-complex 27 3.38e-01 5.63e-01 0.16200 -0.161000 -1.50e-02 1.48e-01 8.93e-01
MAPK-family-signaling-cascades 212 1.42e-04 2.15e-03 0.16100 -0.145000 -7.11e-02 2.97e-04 7.54e-02
COPII-mediated-vesicle-transport 56 9.44e-02 2.67e-01 0.16100 0.067300 1.46e-01 3.84e-01 5.83e-02
LDL-clearance 14 5.77e-01 7.37e-01 0.16100 -0.161000 -2.69e-03 2.97e-01 9.86e-01
Protein-methylation 12 5.99e-01 7.56e-01 0.16100 -0.135000 -8.78e-02 4.19e-01 5.99e-01
Constitutive-Signaling-by-Aberrant-PI3K-in-Cancer 40 2.27e-01 4.53e-01 0.16100 -0.155000 4.34e-02 9.04e-02 6.35e-01
C-type-lectin-receptors-(CLRs) 102 1.64e-02 8.14e-02 0.16100 -0.157000 -3.31e-02 6.18e-03 5.65e-01
Signaling-by-FGFR4 30 3.46e-01 5.65e-01 0.16100 -0.090300 1.33e-01 3.92e-01 2.08e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-1-Promoter 27 3.39e-01 5.63e-01 0.16000 -0.158000 -2.64e-02 1.55e-01 8.12e-01
Interconversion-of-nucleotide-di--and-triphosphates 20 4.96e-01 6.85e-01 0.16000 -0.094500 1.29e-01 4.65e-01 3.17e-01
ROS-and-RNS-production-in-phagocytes 26 3.50e-01 5.65e-01 0.16000 -0.035900 -1.56e-01 7.52e-01 1.69e-01
Arachidonic-acid-metabolism 26 3.85e-01 5.95e-01 0.16000 0.154000 -4.31e-02 1.74e-01 7.04e-01
O-linked-glycosylation-of-mucins 27 3.75e-01 5.87e-01 0.16000 0.050500 -1.52e-01 6.50e-01 1.73e-01
CaM-pathway 29 3.36e-01 5.61e-01 0.15900 -0.017500 1.59e-01 8.71e-01 1.40e-01
Calmodulin-induced-events 29 3.36e-01 5.61e-01 0.15900 -0.017500 1.59e-01 8.71e-01 1.40e-01
SHC-mediated-cascade:FGFR1 10 6.63e-01 8.03e-01 0.15900 0.060500 1.47e-01 7.40e-01 4.20e-01
Interleukin-receptor-SHC-signaling 18 5.11e-01 6.98e-01 0.15900 -0.024100 1.58e-01 8.60e-01 2.47e-01
RHO-GTPases-activate-CIT 16 5.45e-01 7.22e-01 0.15900 0.009540 -1.59e-01 9.47e-01 2.71e-01
Extra-nuclear-estrogen-signaling 58 1.29e-01 3.26e-01 0.15900 0.066200 -1.45e-01 3.84e-01 5.69e-02
Collagen-degradation 20 4.53e-01 6.49e-01 0.15900 -0.028100 -1.57e-01 8.28e-01 2.26e-01
HCMV-Late-Events 49 1.86e-01 3.99e-01 0.15900 -0.101000 1.22e-01 2.21e-01 1.39e-01
Signaling-by-WNT-in-cancer 28 3.43e-01 5.64e-01 0.15900 0.004110 1.59e-01 9.70e-01 1.47e-01
Transport-of-Mature-mRNA-Derived-from-an-Intronless-Transcript 37 2.65e-01 4.90e-01 0.15800 -0.152000 4.53e-02 1.10e-01 6.34e-01
MyD88:MAL(TIRAP)-cascade-initiated-on-plasma-membrane 81 4.58e-02 1.63e-01 0.15800 0.005690 1.58e-01 9.30e-01 1.39e-02
Toll-Like-Receptor-2-(TLR2)-Cascade 81 4.58e-02 1.63e-01 0.15800 0.005690 1.58e-01 9.30e-01 1.39e-02
Toll-Like-Receptor-TLR1:TLR2-Cascade 81 4.58e-02 1.63e-01 0.15800 0.005690 1.58e-01 9.30e-01 1.39e-02
Toll-Like-Receptor-TLR6:TLR2-Cascade 81 4.58e-02 1.63e-01 0.15800 0.005690 1.58e-01 9.30e-01 1.39e-02
Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF) 10 6.77e-01 8.05e-01 0.15800 -0.031000 -1.55e-01 8.65e-01 3.98e-01
O-linked-glycosylation 63 1.06e-01 2.89e-01 0.15700 0.038500 -1.53e-01 5.97e-01 3.63e-02
Signaling-by-FGFR2-in-disease 30 3.28e-01 5.55e-01 0.15600 -0.156000 -7.35e-03 1.39e-01 9.44e-01
mRNA-Splicing 178 8.31e-04 8.54e-03 0.15600 -0.122000 -9.76e-02 5.28e-03 2.52e-02
FCGR3A-mediated-phagocytosis 49 1.48e-01 3.48e-01 0.15600 -0.054900 -1.46e-01 5.07e-01 7.77e-02
Leishmania-phagocytosis 49 1.48e-01 3.48e-01 0.15600 -0.054900 -1.46e-01 5.07e-01 7.77e-02
Parasite-infection 49 1.48e-01 3.48e-01 0.15600 -0.054900 -1.46e-01 5.07e-01 7.77e-02
Regulation-of-insulin-secretion 52 1.52e-01 3.53e-01 0.15500 0.155000 -3.52e-03 5.28e-02 9.65e-01
Negative-regulation-of-MET-activity 16 5.84e-01 7.44e-01 0.15500 -0.068200 1.40e-01 6.37e-01 3.34e-01
Fc-epsilon-receptor-(FCERI)-signaling 113 1.99e-02 9.28e-02 0.15500 -0.152000 3.32e-02 5.45e-03 5.43e-01
N-glycan-trimming-in-the-ER-and-Calnexin/Calreticulin-cycle 34 3.29e-01 5.55e-01 0.15500 -0.115000 1.04e-01 2.47e-01 2.92e-01
IRS-related-events-triggered-by-IGF1R 32 3.18e-01 5.49e-01 0.15500 -0.012800 1.55e-01 9.00e-01 1.30e-01
Cytosolic-sensors-of-pathogen-associated-DNA 57 1.05e-01 2.86e-01 0.15400 -0.109000 -1.09e-01 1.56e-01 1.54e-01
trans-Golgi-Network-Vesicle-Budding 64 1.20e-01 3.12e-01 0.15400 0.142000 -5.83e-02 4.92e-02 4.21e-01
Sulfur-amino-acid-metabolism 19 5.27e-01 7.09e-01 0.15400 -0.045600 1.47e-01 7.31e-01 2.68e-01
SUMOylation-of-DNA-damage-response-and-repair-proteins 67 7.39e-02 2.32e-01 0.15300 0.092700 1.22e-01 1.90e-01 8.38e-02
mRNA-3'-end-processing 53 1.28e-01 3.25e-01 0.15300 -0.094800 -1.20e-01 2.33e-01 1.30e-01
The-NLRP3-inflammasome 11 6.88e-01 8.16e-01 0.15300 0.149000 -3.35e-02 3.91e-01 8.47e-01
DNA-Damage-Recognition-in-GG-NER 37 2.93e-01 5.23e-01 0.15300 -0.145000 4.93e-02 1.28e-01 6.04e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes 28 4.10e-01 6.13e-01 0.15300 0.119000 -9.65e-02 2.78e-01 3.77e-01
Transcriptional-regulation-by-RUNX1 151 4.45e-03 3.05e-02 0.15300 -0.151000 -2.12e-02 1.38e-03 6.53e-01
NEP/NS2-Interacts-with-the-Cellular-Export-Machinery 28 4.08e-01 6.11e-01 0.15200 -0.132000 7.57e-02 2.26e-01 4.88e-01
Surfactant-metabolism 12 6.37e-01 7.87e-01 0.15200 -0.058800 -1.40e-01 7.24e-01 4.00e-01
Synaptic-adhesion-like-molecules 11 7.02e-01 8.28e-01 0.15100 0.139000 -5.90e-02 4.23e-01 7.35e-01
Signaling-by-PDGFR-in-disease 18 5.31e-01 7.12e-01 0.15100 0.011500 1.51e-01 9.33e-01 2.68e-01
Metabolism-of-cofactors 17 5.88e-01 7.48e-01 0.15100 -0.117000 9.61e-02 4.05e-01 4.93e-01
SUMOylation-of-chromatin-organization-proteins 51 1.48e-01 3.48e-01 0.15100 0.077200 1.30e-01 3.41e-01 1.09e-01
TCF-dependent-signaling-in-response-to-WNT 139 9.70e-03 5.44e-02 0.15100 -0.150000 1.96e-02 2.34e-03 6.91e-01
Anchoring-of-the-basal-body-to-the-plasma-membrane 83 6.52e-02 2.10e-01 0.15100 0.147000 -3.36e-02 2.05e-02 5.97e-01
MHC-class-II-antigen-presentation 73 9.52e-02 2.67e-01 0.15100 -0.142000 5.02e-02 3.55e-02 4.59e-01
Metabolism-of-non-coding-RNA 47 1.95e-01 4.09e-01 0.15100 -0.151000 -8.63e-03 7.39e-02 9.19e-01
snRNP-Assembly 47 1.95e-01 4.09e-01 0.15100 -0.151000 -8.63e-03 7.39e-02 9.19e-01
Apoptotic-cleavage-of-cellular-proteins 31 3.34e-01 5.60e-01 0.15100 -0.022800 -1.49e-01 8.27e-01 1.51e-01
Activation-of-BH3-only-proteins 22 4.58e-01 6.54e-01 0.15100 0.149000 2.51e-02 2.28e-01 8.38e-01
RAF/MAP-kinase-cascade 177 1.61e-03 1.29e-02 0.15100 -0.139000 -5.79e-02 1.46e-03 1.85e-01
RNA-Polymerase-I-Promoter-Clearance 49 1.63e-01 3.69e-01 0.15000 -0.132000 -7.27e-02 1.11e-01 3.79e-01
RNA-Polymerase-I-Transcription 49 1.63e-01 3.69e-01 0.15000 -0.132000 -7.27e-02 1.11e-01 3.79e-01
RMTs-methylate-histone-arginines 28 3.87e-01 5.95e-01 0.15000 -0.150000 2.94e-03 1.70e-01 9.79e-01
Inflammasomes 13 6.71e-01 8.03e-01 0.15000 0.103000 -1.09e-01 5.22e-01 4.94e-01
Signal-transduction-by-L1 20 4.86e-01 6.77e-01 0.15000 0.052500 1.40e-01 6.84e-01 2.78e-01
Deadenylation-dependent-mRNA-decay 51 1.59e-01 3.64e-01 0.15000 -0.139000 -5.61e-02 8.70e-02 4.89e-01
Plasma-lipoprotein-assembly,-remodeling,-and-clearance 42 2.81e-01 5.08e-01 0.14900 -0.101000 1.10e-01 2.56e-01 2.20e-01
Ion-homeostasis 36 3.27e-01 5.55e-01 0.14800 -0.049700 1.40e-01 6.06e-01 1.48e-01
Regulation-of-actin-dynamics-for-phagocytic-cup-formation 51 1.66e-01 3.71e-01 0.14800 -0.053200 -1.38e-01 5.11e-01 8.84e-02
Resolution-of-Abasic-Sites-(AP-sites) 33 3.09e-01 5.38e-01 0.14800 -0.132000 -6.65e-02 1.90e-01 5.09e-01
RNA-Polymerase-I-Transcription-Initiation 47 1.88e-01 4.01e-01 0.14700 -0.131000 -6.86e-02 1.22e-01 4.16e-01
NCAM-signaling-for-neurite-out-growth 43 2.19e-01 4.43e-01 0.14700 -0.066200 -1.31e-01 4.53e-01 1.37e-01
PKA-activation-in-glucagon-signalling 13 6.51e-01 7.96e-01 0.14700 0.006970 1.47e-01 9.65e-01 3.59e-01
PTEN-Regulation 131 1.70e-02 8.23e-02 0.14600 -0.144000 2.36e-02 4.39e-03 6.42e-01
Degradation-of-beta-catenin-by-the-destruction-complex 77 7.71e-02 2.40e-01 0.14600 -0.144000 -2.56e-02 2.92e-02 6.98e-01
Telomere-C-strand-(Lagging-Strand)-Synthesis 20 5.33e-01 7.12e-01 0.14600 0.020200 -1.45e-01 8.76e-01 2.63e-01
NS1-Mediated-Effects-on-Host-Pathways 34 3.73e-01 5.85e-01 0.14600 -0.111000 9.43e-02 2.62e-01 3.42e-01
MAPK1/MAPK3-signaling 181 2.17e-03 1.65e-02 0.14600 -0.136000 -5.20e-02 1.62e-03 2.29e-01
RHO-GTPases-Activate-NADPH-Oxidases 16 6.21e-01 7.75e-01 0.14600 -0.134000 5.78e-02 3.55e-01 6.89e-01
Oxidative-Stress-Induced-Senescence 58 1.36e-01 3.32e-01 0.14500 0.064700 1.30e-01 3.94e-01 8.68e-02
Elevation-of-cytosolic-Ca2+-levels 11 7.29e-01 8.36e-01 0.14500 0.101000 -1.04e-01 5.60e-01 5.50e-01
Downregulation-of-ERBB2:ERBB3-signaling 11 7.08e-01 8.28e-01 0.14500 0.010200 -1.45e-01 9.54e-01 4.06e-01
Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer 40 3.07e-01 5.38e-01 0.14500 -0.054500 1.34e-01 5.51e-01 1.42e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-2-Promoter 26 4.33e-01 6.33e-01 0.14500 -0.144000 -1.13e-02 2.03e-01 9.21e-01
Mismatch-Repair 13 6.69e-01 8.03e-01 0.14500 0.144000 -1.91e-02 3.70e-01 9.05e-01
Intrinsic-Pathway-for-Apoptosis 40 3.09e-01 5.38e-01 0.14500 0.134000 -5.58e-02 1.44e-01 5.42e-01
NoRC-negatively-regulates-rRNA-expression 45 2.15e-01 4.36e-01 0.14500 -0.069400 -1.27e-01 4.21e-01 1.41e-01
AURKA-Activation-by-TPX2 61 1.76e-01 3.82e-01 0.14400 0.126000 -6.88e-02 8.89e-02 3.53e-01
Loss-of-Nlp-from-mitotic-centrosomes 61 1.76e-01 3.82e-01 0.14400 0.126000 -6.88e-02 8.89e-02 3.53e-01
Loss-of-proteins-required-for-interphase-microtubule-organization-from-the-centrosome 61 1.76e-01 3.82e-01 0.14400 0.126000 -6.88e-02 8.89e-02 3.53e-01
Retrograde-transport-at-the-Trans-Golgi-Network 45 2.29e-01 4.54e-01 0.14400 0.039500 1.38e-01 6.47e-01 1.09e-01
Signaling-by-NOTCH 156 5.60e-03 3.63e-02 0.14300 -0.127000 -6.57e-02 6.18e-03 1.58e-01
Pre-NOTCH-Expression-and-Processing 46 2.48e-01 4.81e-01 0.14300 -0.142000 1.30e-02 9.51e-02 8.79e-01
Negative-regulation-of-FGFR1-signaling 20 5.52e-01 7.23e-01 0.14300 -0.027900 1.40e-01 8.29e-01 2.78e-01
ERBB2-Regulates-Cell-Motility 10 7.23e-01 8.34e-01 0.14200 0.135000 4.36e-02 4.59e-01 8.11e-01
Integration-of-energy-metabolism 78 8.84e-02 2.58e-01 0.14200 0.141000 1.65e-02 3.14e-02 8.02e-01
Signaling-by-PDGF 45 2.29e-01 4.54e-01 0.14200 -0.059100 -1.29e-01 4.93e-01 1.34e-01
RNA-Polymerase-III-Abortive-And-Retractive-Initiation 40 2.97e-01 5.27e-01 0.14200 -0.142000 1.75e-03 1.21e-01 9.85e-01
RNA-Polymerase-III-Transcription 40 2.97e-01 5.27e-01 0.14200 -0.142000 1.75e-03 1.21e-01 9.85e-01
Notch-HLH-transcription-pathway 27 4.73e-01 6.64e-01 0.14200 -0.123000 7.09e-02 2.71e-01 5.24e-01
Early-Phase-of-HIV-Life-Cycle 12 6.76e-01 8.05e-01 0.14100 0.127000 6.19e-02 4.46e-01 7.10e-01
Cell-recruitment-(pro-inflammatory-response) 16 6.23e-01 7.75e-01 0.14100 0.141000 -1.18e-02 3.30e-01 9.35e-01
Purinergic-signaling-in-leishmaniasis-infection 16 6.23e-01 7.75e-01 0.14100 0.141000 -1.18e-02 3.30e-01 9.35e-01
EGFR-downregulation 23 5.21e-01 7.05e-01 0.14100 -0.136000 3.71e-02 2.60e-01 7.58e-01
Regulation-of-beta-cell-development 17 6.27e-01 7.78e-01 0.14000 -0.126000 6.24e-02 3.69e-01 6.56e-01
Signaling-by-FGFR4-in-disease 10 7.64e-01 8.53e-01 0.14000 -0.080600 1.14e-01 6.59e-01 5.31e-01
PRC2-methylates-histones-and-DNA 11 7.45e-01 8.40e-01 0.14000 -0.087600 1.09e-01 6.15e-01 5.31e-01
TBC/RABGAPs 41 3.04e-01 5.36e-01 0.14000 -0.011800 1.39e-01 8.96e-01 1.23e-01
Signaling-by-NOTCH3 42 2.64e-01 4.90e-01 0.14000 -0.058500 -1.27e-01 5.12e-01 1.55e-01
Signaling-by-ERBB2-KD-Mutants 21 5.32e-01 7.12e-01 0.14000 0.139000 1.45e-02 2.71e-01 9.09e-01
Platelet-Aggregation-(Plug-Formation) 24 5.29e-01 7.11e-01 0.14000 0.107000 -8.93e-02 3.64e-01 4.49e-01
ADORA2B-mediated-anti-inflammatory-cytokines-production 44 3.12e-01 5.41e-01 0.13900 0.093300 -1.04e-01 2.85e-01 2.35e-01
mRNA-Capping 29 4.28e-01 6.30e-01 0.13900 0.000434 -1.39e-01 9.97e-01 1.95e-01
Transport-of-bile-salts-and-organic-acids,-metal-ions-and-amine-compounds 34 3.41e-01 5.64e-01 0.13900 0.124000 6.32e-02 2.11e-01 5.24e-01
PI-Metabolism 74 9.53e-02 2.67e-01 0.13900 0.091000 1.04e-01 1.76e-01 1.21e-01
Lysosome-Vesicle-Biogenesis 27 4.40e-01 6.40e-01 0.13800 -0.037600 -1.33e-01 7.36e-01 2.32e-01
Sphingolipid-metabolism 60 1.97e-01 4.11e-01 0.13800 0.131000 -4.32e-02 7.89e-02 5.64e-01
Cyclin-D-associated-events-in-G1 36 3.93e-01 6.01e-01 0.13800 0.088000 -1.06e-01 3.61e-01 2.70e-01
G1-Phase 36 3.93e-01 6.01e-01 0.13800 0.088000 -1.06e-01 3.61e-01 2.70e-01
Downregulation-of-ERBB2-signaling 23 5.46e-01 7.22e-01 0.13800 0.064000 -1.22e-01 5.95e-01 3.11e-01
Post-NMDA-receptor-activation-events 45 2.98e-01 5.27e-01 0.13800 -0.041100 1.31e-01 6.34e-01 1.28e-01
Synthesis-of-DNA 97 5.00e-02 1.76e-01 0.13700 -0.113000 -7.71e-02 5.41e-02 1.90e-01
Phase-II---Conjugation-of-compounds 51 2.13e-01 4.34e-01 0.13700 0.056600 1.25e-01 4.85e-01 1.24e-01
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein 64 1.99e-01 4.12e-01 0.13600 0.101000 -9.18e-02 1.64e-01 2.05e-01
Vpr-mediated-nuclear-import-of-PICs 30 4.61e-01 6.57e-01 0.13600 -0.060700 1.22e-01 5.65e-01 2.48e-01
Signaling-by-Type-1-Insulin-like-Growth-Factor-1-Receptor-(IGF1R) 34 3.98e-01 6.04e-01 0.13600 -0.019700 1.35e-01 8.43e-01 1.75e-01
Activation-of-NMDA-receptors-and-postsynaptic-events 52 2.69e-01 4.95e-01 0.13600 -0.073100 1.14e-01 3.63e-01 1.54e-01
Cyclin-A:Cdk2-associated-events-at-S-phase-entry 75 1.16e-01 3.03e-01 0.13600 -0.133000 -2.62e-02 4.65e-02 6.96e-01
Processing-of-DNA-double-strand-break-ends 47 3.10e-01 5.39e-01 0.13500 0.098300 -9.31e-02 2.44e-01 2.70e-01
DNA-Replication 99 5.13e-02 1.78e-01 0.13500 -0.114000 -7.24e-02 4.97e-02 2.14e-01
Synthesis-of-PE 11 7.45e-01 8.40e-01 0.13500 -0.024300 1.33e-01 8.89e-01 4.45e-01
Signaling-by-ERBB2-ECD-mutants 16 6.21e-01 7.75e-01 0.13500 0.122000 5.84e-02 3.99e-01 6.86e-01
Nucleotide-salvage 16 6.72e-01 8.03e-01 0.13500 0.091500 -9.95e-02 5.27e-01 4.91e-01
Purine-salvage 11 7.60e-01 8.50e-01 0.13500 0.078600 -1.10e-01 6.52e-01 5.28e-01
IGF1R-signaling-cascade 33 3.99e-01 6.04e-01 0.13500 0.008610 1.35e-01 9.32e-01 1.81e-01
Diseases-associated-with-glycosaminoglycan-metabolism 31 4.50e-01 6.47e-01 0.13500 0.042000 -1.28e-01 6.86e-01 2.18e-01
Role-of-LAT2/NTAL/LAB-on-calcium-mobilization 12 7.03e-01 8.28e-01 0.13500 0.125000 5.06e-02 4.55e-01 7.62e-01
IL-6-type-cytokine-receptor-ligand-interactions 10 7.46e-01 8.40e-01 0.13400 0.122000 5.49e-02 5.03e-01 7.64e-01
Nephrin-family-interactions 18 5.84e-01 7.44e-01 0.13400 -0.096000 -9.37e-02 4.81e-01 4.92e-01
Signaling-by-FGFR3 31 4.68e-01 6.61e-01 0.13400 -0.089800 9.96e-02 3.87e-01 3.37e-01
Fcgamma-receptor-(FCGR)-dependent-phagocytosis 73 1.27e-01 3.23e-01 0.13400 -0.032500 -1.30e-01 6.31e-01 5.51e-02
Prolonged-ERK-activation-events 13 7.24e-01 8.34e-01 0.13400 -0.117000 6.47e-02 4.64e-01 6.87e-01
VLDLR-internalisation-and-degradation 11 7.39e-01 8.40e-01 0.13400 -0.133000 -1.09e-02 4.44e-01 9.50e-01
Signal-regulatory-protein-family-interactions 11 7.45e-01 8.40e-01 0.13400 0.133000 -9.89e-03 4.44e-01 9.55e-01
PIP3-activates-AKT-signaling 218 4.90e-03 3.30e-02 0.13400 -0.118000 6.32e-02 2.81e-03 1.10e-01
HDR-through-MMEJ-(alt-NHEJ) 10 7.84e-01 8.66e-01 0.13400 0.099700 -8.89e-02 5.85e-01 6.27e-01
HATs-acetylate-histones 75 1.54e-01 3.58e-01 0.13400 -0.051000 1.23e-01 4.46e-01 6.50e-02
Factors-involved-in-megakaryocyte-development-and-platelet-production 83 1.04e-01 2.86e-01 0.13300 0.132000 1.53e-02 3.76e-02 8.09e-01
ZBP1(DAI)-mediated-induction-of-type-I-IFNs 19 6.19e-01 7.75e-01 0.13300 0.127000 -3.89e-02 3.37e-01 7.69e-01
Role-of-phospholipids-in-phagocytosis 22 5.87e-01 7.48e-01 0.13300 0.113000 -6.98e-02 3.60e-01 5.71e-01
TRAF3-dependent-IRF-activation-pathway 12 7.10e-01 8.28e-01 0.13300 -0.120000 -5.53e-02 4.70e-01 7.40e-01
BMAL1:CLOCK,NPAS2-activates-circadian-gene-expression 24 5.36e-01 7.14e-01 0.13300 -0.014100 1.32e-01 9.05e-01 2.64e-01
Cell-Cell-communication 77 1.12e-01 2.97e-01 0.13200 -0.119000 -5.73e-02 7.03e-02 3.85e-01
Interferon-Signaling 129 2.42e-02 1.06e-01 0.13200 -0.104000 -8.21e-02 4.21e-02 1.08e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE 27 4.95e-01 6.85e-01 0.13200 0.008290 -1.32e-01 9.41e-01 2.36e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE-during-HIV-infection 27 4.95e-01 6.85e-01 0.13200 0.008290 -1.32e-01 9.41e-01 2.36e-01
Epigenetic-regulation-of-gene-expression 82 1.03e-01 2.83e-01 0.13200 -0.123000 -4.67e-02 5.46e-02 4.65e-01
CLEC7A-(Dectin-1)-signaling 88 9.33e-02 2.65e-01 0.13200 -0.129000 -2.45e-02 3.65e-02 6.91e-01
Keratan-sulfate-biosynthesis 18 6.48e-01 7.94e-01 0.13100 -0.120000 5.42e-02 3.80e-01 6.91e-01
Disorders-of-transmembrane-transporters 120 5.45e-02 1.87e-01 0.13100 -0.124000 4.31e-02 1.92e-02 4.16e-01
Platelet-sensitization-by-LDL 14 6.70e-01 8.03e-01 0.13100 0.097400 8.80e-02 5.28e-01 5.69e-01
Transcriptional-regulation-by-RUNX2 97 7.17e-02 2.27e-01 0.13100 -0.126000 -3.51e-02 3.18e-02 5.51e-01
Transport-of-Mature-mRNAs-Derived-from-Intronless-Transcripts 38 3.96e-01 6.03e-01 0.13100 -0.125000 3.89e-02 1.83e-01 6.78e-01
ERKs-are-inactivated 12 7.13e-01 8.28e-01 0.13100 -0.109000 -7.17e-02 5.12e-01 6.67e-01
Base-Excision-Repair 39 3.32e-01 5.58e-01 0.13100 -0.101000 -8.34e-02 2.77e-01 3.68e-01
Resolution-of-D-Loop-Structures 17 6.71e-01 8.03e-01 0.13000 0.113000 -6.55e-02 4.22e-01 6.40e-01
Heparan-sulfate/heparin-(HS-GAG)-metabolism 35 4.25e-01 6.29e-01 0.13000 0.029600 -1.27e-01 7.62e-01 1.95e-01
Regulation-of-FZD-by-ubiquitination 13 7.40e-01 8.40e-01 0.13000 -0.065600 1.12e-01 6.82e-01 4.85e-01
TAK1-activates-NFkB-by-phosphorylation-and-activation-of-IKKs-complex 22 5.53e-01 7.23e-01 0.12800 0.114000 5.88e-02 3.55e-01 6.33e-01
PCNA-Dependent-Long-Patch-Base-Excision-Repair 19 6.54e-01 7.99e-01 0.12800 0.094200 -8.67e-02 4.77e-01 5.13e-01
MyD88-independent-TLR4-cascade 85 1.26e-01 3.22e-01 0.12800 -0.002560 1.28e-01 9.67e-01 4.24e-02
TRIF(TICAM1)-mediated-TLR4-signaling 85 1.26e-01 3.22e-01 0.12800 -0.002560 1.28e-01 9.67e-01 4.24e-02
Activation-of-gene-expression-by-SREBF-(SREBP) 38 3.68e-01 5.80e-01 0.12700 0.117000 5.00e-02 2.11e-01 5.94e-01
Infectious-disease 483 3.81e-06 1.15e-04 0.12700 -0.073100 -1.04e-01 6.43e-03 9.94e-05
Gap-filling-DNA-repair-synthesis-and-ligation-in-TC-NER 61 1.99e-01 4.12e-01 0.12700 -0.057600 -1.14e-01 4.37e-01 1.25e-01
STING-mediated-induction-of-host-immune-responses 12 7.61e-01 8.50e-01 0.12700 0.049600 -1.17e-01 7.66e-01 4.83e-01
TNF-signaling 38 4.29e-01 6.30e-01 0.12700 -0.110000 6.36e-02 2.41e-01 4.98e-01
SUMOylation-of-transcription-factors 15 6.71e-01 8.03e-01 0.12700 0.097800 8.04e-02 5.12e-01 5.90e-01
FLT3-Signaling 193 8.53e-03 4.94e-02 0.12600 -0.124000 -2.39e-02 3.06e-03 5.69e-01
Centrosome-maturation 70 2.15e-01 4.36e-01 0.12600 0.110000 -6.18e-02 1.12e-01 3.72e-01
Recruitment-of-mitotic-centrosome-proteins-and-complexes 70 2.15e-01 4.36e-01 0.12600 0.110000 -6.18e-02 1.12e-01 3.72e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH6-(MutSalpha) 12 7.37e-01 8.40e-01 0.12600 0.121000 3.54e-02 4.68e-01 8.32e-01
Homologous-DNA-Pairing-and-Strand-Exchange 27 5.11e-01 6.98e-01 0.12600 0.123000 2.67e-02 2.69e-01 8.10e-01
Dual-incision-in-TC-NER 62 2.17e-01 4.40e-01 0.12600 -0.021500 -1.24e-01 7.70e-01 9.20e-02
Nuclear-import-of-Rev-protein 29 5.32e-01 7.12e-01 0.12500 -0.053500 1.13e-01 6.18e-01 2.93e-01
SUMOylation 139 3.35e-02 1.33e-01 0.12500 0.028900 1.22e-01 5.57e-01 1.36e-02
Separation-of-Sister-Chromatids 130 5.52e-02 1.88e-01 0.12500 -0.121000 3.00e-02 1.73e-02 5.56e-01
Cyclin-E-associated-events-during-G1/S-transition 73 1.69e-01 3.75e-01 0.12500 -0.122000 -2.56e-02 7.17e-02 7.06e-01
Phase-I---Functionalization-of-compounds 45 3.48e-01 5.65e-01 0.12400 0.124000 3.19e-03 1.49e-01 9.70e-01
Presynaptic-phase-of-homologous-DNA-pairing-and-strand-exchange 26 5.18e-01 7.04e-01 0.12400 0.108000 6.07e-02 3.40e-01 5.93e-01
Activation-of-ATR-in-response-to-replication-stress 27 5.60e-01 7.26e-01 0.12400 0.049700 -1.13e-01 6.55e-01 3.08e-01
Resolution-of-D-loop-Structures-through-Holliday-Junction-Intermediates 16 7.04e-01 8.28e-01 0.12400 0.119000 -3.48e-02 4.11e-01 8.09e-01
Transcriptional-Regulation-by-VENTX 33 4.42e-01 6.42e-01 0.12400 -0.114000 -4.76e-02 2.57e-01 6.36e-01
Caspase-activation-via-Death-Receptors-in-the-presence-of-ligand 12 7.79e-01 8.63e-01 0.12300 0.064000 -1.05e-01 7.01e-01 5.30e-01
Negative-epigenetic-regulation-of-rRNA-expression 48 3.08e-01 5.38e-01 0.12300 -0.054600 -1.10e-01 5.13e-01 1.88e-01
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic 149 2.52e-02 1.09e-01 0.12200 0.085400 8.78e-02 7.29e-02 6.50e-02
Neurexins-and-neuroligins 29 5.54e-01 7.23e-01 0.12200 0.085400 -8.78e-02 4.26e-01 4.14e-01
Beta-catenin-independent-WNT-signaling 121 5.88e-02 1.98e-01 0.12200 -0.118000 -3.09e-02 2.52e-02 5.59e-01
Zinc-transporters 10 7.91e-01 8.70e-01 0.12200 -0.119000 -2.75e-02 5.16e-01 8.80e-01
RHO-GTPases-activate-PKNs 27 5.49e-01 7.23e-01 0.12200 0.006210 -1.22e-01 9.55e-01 2.74e-01
FOXO-mediated-transcription 51 3.24e-01 5.52e-01 0.12200 -0.005920 1.22e-01 9.42e-01 1.34e-01
Transcriptional-Regulation-by-MECP2 42 4.03e-01 6.07e-01 0.12200 -0.018100 1.20e-01 8.39e-01 1.78e-01
SUMO-E3-ligases-SUMOylate-target-proteins 134 4.45e-02 1.62e-01 0.12200 0.031000 1.18e-01 5.37e-01 1.91e-02
HDR-through-Homologous-Recombination-(HRR)-or-Single-Strand-Annealing-(SSA) 70 2.41e-01 4.72e-01 0.12200 0.061000 -1.05e-01 3.78e-01 1.29e-01
Regulation-of-TP53-Activity-through-Association-with-Co-factors 10 8.12e-01 8.85e-01 0.12100 0.045700 -1.13e-01 8.03e-01 5.38e-01
Intracellular-signaling-by-second-messengers 252 6.92e-03 4.19e-02 0.12100 -0.098800 7.03e-02 7.21e-03 5.60e-02
Negative-regulation-of-NMDA-receptor-mediated-neuronal-transmission 13 7.43e-01 8.40e-01 0.12100 -0.120000 -1.74e-02 4.54e-01 9.14e-01
Protein-protein-interactions-at-synapses 43 4.20e-01 6.24e-01 0.12100 0.103000 -6.37e-02 2.43e-01 4.70e-01
Glycosaminoglycan-metabolism 84 1.87e-01 4.00e-01 0.12100 0.101000 -6.64e-02 1.10e-01 2.94e-01
Interleukin-1-signaling 88 1.65e-01 3.70e-01 0.12100 -0.112000 4.41e-02 6.86e-02 4.75e-01
COPI-mediated-anterograde-transport 73 1.73e-01 3.80e-01 0.12100 0.099200 6.90e-02 1.43e-01 3.09e-01
DAG-and-IP3-signaling 35 4.59e-01 6.55e-01 0.12100 0.005320 1.21e-01 9.57e-01 2.17e-01
G2/M-Checkpoints 103 8.88e-02 2.58e-01 0.11900 -0.092800 -7.52e-02 1.04e-01 1.88e-01
ATF6-(ATF6-alpha)-activates-chaperones 12 7.59e-01 8.50e-01 0.11900 -0.043700 -1.11e-01 7.93e-01 5.06e-01
Toll-Like-Receptor-3-(TLR3)-Cascade 83 1.68e-01 3.74e-01 0.11900 0.004180 1.19e-01 9.48e-01 6.11e-02
RIP-mediated-NFkB-activation-via-ZBP1 16 7.07e-01 8.28e-01 0.11900 0.119000 8.32e-03 4.11e-01 9.54e-01
Processing-of-Capped-Intron-Containing-Pre-mRNA 225 6.12e-03 3.79e-02 0.11800 -0.101000 -6.21e-02 9.58e-03 1.10e-01
Signaling-by-VEGF 92 1.21e-01 3.12e-01 0.11800 -0.073700 -9.22e-02 2.23e-01 1.27e-01
SUMOylation-of-ubiquitinylation-proteins 35 4.68e-01 6.61e-01 0.11800 0.019600 1.16e-01 8.41e-01 2.34e-01
Recruitment-of-NuMA-to-mitotic-centrosomes 70 2.57e-01 4.85e-01 0.11800 0.109000 -4.36e-02 1.14e-01 5.29e-01
Regulation-of-HSF1-mediated-heat-shock-response 72 2.55e-01 4.85e-01 0.11700 -0.103000 5.67e-02 1.33e-01 4.06e-01
Interleukin-4-and-Interleukin-13-signaling 65 2.47e-01 4.79e-01 0.11700 -0.023500 -1.15e-01 7.43e-01 1.10e-01
Leishmania-infection 133 6.75e-02 2.16e-01 0.11700 0.007510 -1.17e-01 8.81e-01 2.03e-02
Formation-of-TC-NER-Pre-Incision-Complex 52 3.18e-01 5.49e-01 0.11700 -0.110000 -4.10e-02 1.72e-01 6.10e-01
Activation-of-HOX-genes-during-differentiation 47 3.87e-01 5.95e-01 0.11700 -0.116000 1.18e-02 1.68e-01 8.89e-01
Activation-of-anterior-HOX-genes-in-hindbrain-development-during-early-embryogenesis 47 3.87e-01 5.95e-01 0.11700 -0.116000 1.18e-02 1.68e-01 8.89e-01
RUNX2-regulates-bone-development 25 6.15e-01 7.72e-01 0.11700 0.111000 -3.50e-02 3.35e-01 7.62e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-GG-NER 22 6.24e-01 7.76e-01 0.11600 -0.029100 -1.13e-01 8.13e-01 3.61e-01
EML4-and-NUDC-in-mitotic-spindle-formation 64 2.80e-01 5.08e-01 0.11600 -0.008150 1.15e-01 9.10e-01 1.11e-01
Cooperation-of-PDCL-(PhLP1)-and-TRiC/CCT-in-G-protein-beta-folding 27 6.10e-01 7.67e-01 0.11500 0.098300 -6.03e-02 3.77e-01 5.88e-01
Transcriptional-regulation-by-small-RNAs 43 4.32e-01 6.33e-01 0.11500 -0.114000 1.44e-02 1.95e-01 8.71e-01
TICAM1,-RIP1-mediated-IKK-complex-recruitment 17 7.24e-01 8.34e-01 0.11400 0.023000 -1.12e-01 8.70e-01 4.24e-01
Hedgehog-'off'-state 89 1.82e-01 3.91e-01 0.11400 -0.113000 1.41e-02 6.48e-02 8.19e-01
Developmental-Biology 606 4.55e-06 1.33e-04 0.11400 -0.053500 -1.01e-01 2.64e-02 2.80e-05
Diseases-of-carbohydrate-metabolism 28 5.59e-01 7.26e-01 0.11400 0.036800 1.08e-01 7.37e-01 3.24e-01
Incretin-synthesis,-secretion,-and-inactivation 10 8.38e-01 8.98e-01 0.11400 0.090200 -6.92e-02 6.21e-01 7.05e-01
Transmission-across-Chemical-Synapses 132 6.43e-02 2.09e-01 0.11400 0.104000 4.65e-02 4.02e-02 3.57e-01
SUMOylation-of-DNA-methylation-proteins 15 7.69e-01 8.55e-01 0.11300 0.075400 -8.48e-02 6.13e-01 5.70e-01
CD28-dependent-PI3K/Akt-signaling 19 7.17e-01 8.29e-01 0.11300 -0.086200 7.38e-02 5.16e-01 5.78e-01
EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination 17 7.12e-01 8.28e-01 0.11300 0.112000 1.58e-02 4.23e-01 9.10e-01
Vasopressin-regulates-renal-water-homeostasis-via-Aquaporins 29 5.89e-01 7.48e-01 0.11300 0.108000 -3.55e-02 3.16e-01 7.41e-01
Amplification--of-signal-from-unattached--kinetochores-via-a-MAD2--inhibitory-signal 60 3.24e-01 5.52e-01 0.11300 -0.016200 1.12e-01 8.28e-01 1.33e-01
Amplification-of-signal-from-the-kinetochores 60 3.24e-01 5.52e-01 0.11300 -0.016200 1.12e-01 8.28e-01 1.33e-01
Calnexin/calreticulin-cycle 25 6.47e-01 7.94e-01 0.11300 -0.072500 8.67e-02 5.30e-01 4.53e-01
ER-to-Golgi-Anterograde-Transport 116 8.88e-02 2.58e-01 0.11300 0.060600 9.53e-02 2.60e-01 7.69e-02
Regulation-of-TNFR1-signaling 29 5.52e-01 7.23e-01 0.11300 -0.107000 -3.72e-02 3.21e-01 7.29e-01
Neuronal-System 189 1.94e-02 9.09e-02 0.11300 0.083800 7.55e-02 4.78e-02 7.44e-02
Defective-TPR-may-confer-susceptibility-towards-thyroid-papillary-carcinoma-(TPC) 27 6.27e-01 7.78e-01 0.11300 -0.074400 8.45e-02 5.04e-01 4.47e-01
Regulation-of-Glucokinase-by-Glucokinase-Regulatory-Protein 27 6.27e-01 7.78e-01 0.11300 -0.074400 8.45e-02 5.04e-01 4.47e-01
G-alpha-(i)-signalling-events 148 8.03e-02 2.45e-01 0.11200 0.066200 -9.06e-02 1.66e-01 5.78e-02
RHO-GTPases-Activate-WASPs-and-WAVEs 30 5.35e-01 7.14e-01 0.11200 -0.073700 -8.44e-02 4.85e-01 4.24e-01
Sialic-acid-metabolism 22 6.43e-01 7.91e-01 0.11200 -0.107000 -3.30e-02 3.85e-01 7.89e-01
Translesion-synthesis-by-POLK 15 7.33e-01 8.38e-01 0.11200 0.093300 6.19e-02 5.32e-01 6.78e-01
Glucagon-like-Peptide-1-(GLP1)-regulates-insulin-secretion 28 6.23e-01 7.75e-01 0.11200 0.082600 -7.50e-02 4.50e-01 4.93e-01
Paradoxical-activation-of-RAF-signaling-by-kinase-inactive-BRAF 38 5.23e-01 7.05e-01 0.11100 0.094600 -5.89e-02 3.13e-01 5.30e-01
Signaling-by-RAS-mutants 38 5.23e-01 7.05e-01 0.11100 0.094600 -5.89e-02 3.13e-01 5.30e-01
Signaling-by-moderate-kinase-activity-BRAF-mutants 38 5.23e-01 7.05e-01 0.11100 0.094600 -5.89e-02 3.13e-01 5.30e-01
Signaling-downstream-of-RAS-mutants 38 5.23e-01 7.05e-01 0.11100 0.094600 -5.89e-02 3.13e-01 5.30e-01
Metalloprotease-DUBs 13 8.01e-01 8.77e-01 0.11100 -0.099500 4.88e-02 5.35e-01 7.61e-01
Unblocking-of-NMDA-receptors,-glutamate-binding-and-activation 10 8.46e-01 9.03e-01 0.11100 -0.088300 6.69e-02 6.29e-01 7.14e-01
Activation-of-PPARGC1A-(PGC-1alpha)-by-phosphorylation 10 8.19e-01 8.88e-01 0.11000 0.053900 9.62e-02 7.68e-01 5.98e-01
PPARA-activates-gene-expression 102 1.62e-01 3.69e-01 0.11000 -0.010300 1.10e-01 8.57e-01 5.63e-02
Transport-of-the-SLBP-independent-Mature-mRNA 31 5.96e-01 7.54e-01 0.11000 -0.095000 5.55e-02 3.60e-01 5.93e-01
Sphingolipid-de-novo-biosynthesis 30 5.93e-01 7.52e-01 0.11000 -0.107000 2.52e-02 3.11e-01 8.12e-01
Signaling-by-FGFR3-fusions-in-cancer 10 8.49e-01 9.04e-01 0.10900 -0.086100 6.74e-02 6.37e-01 7.12e-01
Homology-Directed-Repair 76 2.79e-01 5.07e-01 0.10900 0.037400 -1.03e-01 5.74e-01 1.22e-01
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2 12 8.22e-01 8.88e-01 0.10900 -0.089100 6.30e-02 5.93e-01 7.06e-01
SUMOylation-of-SUMOylation-proteins 31 5.76e-01 7.36e-01 0.10800 0.001200 1.08e-01 9.91e-01 2.96e-01
DNA-Double-Strand-Break-Response 34 5.51e-01 7.23e-01 0.10800 -0.108000 7.45e-03 2.75e-01 9.40e-01
Initiation-of-Nuclear-Envelope-(NE)-Reformation 16 7.33e-01 8.38e-01 0.10800 0.081000 7.17e-02 5.75e-01 6.20e-01
Negative-regulation-of-MAPK-pathway 35 5.52e-01 7.23e-01 0.10800 -0.106000 2.08e-02 2.78e-01 8.32e-01
TNFR1-induced-NFkappaB-signaling-pathway 23 6.89e-01 8.16e-01 0.10800 -0.049300 9.61e-02 6.82e-01 4.25e-01
Signaling-by-EGFR-in-Cancer 19 7.05e-01 8.28e-01 0.10800 -0.104000 -2.88e-02 4.34e-01 8.28e-01
EPH-ephrin-mediated-repulsion-of-cells 35 5.12e-01 6.98e-01 0.10700 -0.065400 -8.53e-02 5.04e-01 3.83e-01
TICAM1,TRAF6-dependent-induction-of-TAK1-complex 10 8.34e-01 8.96e-01 0.10700 -0.105000 -2.40e-02 5.67e-01 8.96e-01
Aquaporin-mediated-transport 30 6.09e-01 7.66e-01 0.10700 0.104000 -2.42e-02 3.23e-01 8.18e-01
Translesion-Synthesis-by-POLH 16 7.80e-01 8.63e-01 0.10700 -0.079700 7.09e-02 5.81e-01 6.24e-01
Signaling-by-SCF-KIT 36 5.69e-01 7.31e-01 0.10600 -0.096800 4.28e-02 3.15e-01 6.57e-01
Dual-Incision-in-GG-NER 38 5.54e-01 7.23e-01 0.10600 0.045200 -9.55e-02 6.30e-01 3.09e-01
Negative-regulation-of-the-PI3K/AKT-network 73 3.31e-01 5.58e-01 0.10600 -0.080100 6.89e-02 2.37e-01 3.10e-01
Biological-oxidations 100 1.65e-01 3.70e-01 0.10500 0.092300 5.03e-02 1.11e-01 3.85e-01
Regulation-of-lipid-metabolism-by-PPARalpha 104 1.84e-01 3.96e-01 0.10500 -0.010000 1.05e-01 8.60e-01 6.59e-02
HIV-Infection 202 3.53e-02 1.39e-01 0.10500 -0.105000 -4.34e-03 1.04e-02 9.16e-01
Signaling-by-Insulin-receptor 52 4.33e-01 6.34e-01 0.10500 -0.017500 1.04e-01 8.28e-01 1.97e-01
Signaling-by-Hedgehog 116 1.75e-01 3.82e-01 0.10500 -0.091400 5.10e-02 8.98e-02 3.44e-01
Kinesins 20 7.15e-01 8.28e-01 0.10400 0.104000 1.04e-02 4.22e-01 9.36e-01
GPCR-downstream-signalling 295 1.03e-02 5.68e-02 0.10400 0.015700 -1.03e-01 6.46e-01 2.51e-03
RNA-Polymerase-III-Transcription-Initiation-From-Type-3-Promoter 28 6.15e-01 7.72e-01 0.10400 -0.034700 -9.79e-02 7.51e-01 3.70e-01
Recruitment-and-ATM-mediated-phosphorylation-of-repair-and-signaling-proteins-at-DNA-double-strand-breaks 33 5.91e-01 7.50e-01 0.10400 -0.103000 1.07e-02 3.05e-01 9.15e-01
Ovarian-tumor-domain-proteases 32 5.71e-01 7.31e-01 0.10400 -0.047200 -9.22e-02 6.44e-01 3.67e-01
Cellular-responses-to-stress 435 5.80e-04 6.75e-03 0.10300 -0.064500 -8.08e-02 2.23e-02 4.15e-03
Plasma-lipoprotein-clearance 22 6.97e-01 8.25e-01 0.10300 -0.103000 -1.05e-02 4.05e-01 9.32e-01
Transcriptional-regulation-of-granulopoiesis 23 7.02e-01 8.28e-01 0.10300 0.101000 -2.16e-02 4.04e-01 8.58e-01
Transport-to-the-Golgi-and-subsequent-modification 139 9.07e-02 2.61e-01 0.10200 0.072900 7.19e-02 1.39e-01 1.45e-01
Endogenous-sterols 14 7.96e-01 8.73e-01 0.10200 -0.015600 -1.01e-01 9.20e-01 5.12e-01
Pre-NOTCH-Processing-in-Golgi 17 7.45e-01 8.40e-01 0.10200 -0.081300 -6.18e-02 5.62e-01 6.59e-01
Mitotic-Spindle-Checkpoint 75 3.21e-01 5.51e-01 0.10200 -0.013300 1.01e-01 8.43e-01 1.32e-01
Cellular-responses-to-external-stimuli 438 7.35e-04 7.89e-03 0.10100 -0.060200 -8.17e-02 3.22e-02 3.65e-03
Interactions-of-Vpr-with-host-cellular-proteins 32 6.37e-01 7.87e-01 0.10100 -0.056900 8.39e-02 5.78e-01 4.12e-01
Apoptotic-execution-phase 38 5.40e-01 7.17e-01 0.10100 -0.023900 -9.84e-02 7.99e-01 2.94e-01
DCC-mediated-attractive-signaling 13 8.15e-01 8.86e-01 0.10100 -0.100000 -1.09e-02 5.31e-01 9.46e-01
RNA-Polymerase-III-Transcription-Initiation 35 5.59e-01 7.26e-01 0.10100 -0.085900 -5.23e-02 3.79e-01 5.93e-01
PTK6-Regulates-RHO-GTPases,-RAS-GTPase-and-MAP-kinases 12 8.46e-01 9.03e-01 0.10100 0.084600 -5.43e-02 6.12e-01 7.45e-01
TP53-Regulates-Transcription-of-DNA-Repair-Genes 53 4.50e-01 6.47e-01 0.10000 0.004600 -1.00e-01 9.54e-01 2.07e-01
Degradation-of-cysteine-and-homocysteine 10 8.71e-01 9.18e-01 0.09980 -0.087900 4.72e-02 6.30e-01 7.96e-01
PI5P,-PP2A-and-IER3-Regulate-PI3K/AKT-Signaling 66 4.12e-01 6.15e-01 0.09950 -0.072700 6.79e-02 3.07e-01 3.41e-01
Regulation-of-PLK1-Activity-at-G2/M-Transition 74 3.59e-01 5.72e-01 0.09940 0.091900 -3.79e-02 1.72e-01 5.73e-01
Intra-Golgi-traffic 39 5.92e-01 7.50e-01 0.09930 -0.059800 7.93e-02 5.18e-01 3.92e-01
Resolution-of-Sister-Chromatid-Cohesion 69 3.58e-01 5.72e-01 0.09910 0.003420 9.91e-02 9.61e-01 1.55e-01
Metabolic-disorders-of-biological-oxidation-enzymes 16 8.05e-01 8.79e-01 0.09890 -0.086200 4.86e-02 5.51e-01 7.36e-01
FCERI-mediated-Ca+2-mobilization 22 7.09e-01 8.28e-01 0.09880 -0.094300 -2.94e-02 4.44e-01 8.11e-01
Gene-Silencing-by-RNA 58 4.45e-01 6.44e-01 0.09880 -0.095300 2.62e-02 2.10e-01 7.30e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest 13 8.19e-01 8.88e-01 0.09870 -0.096700 -2.00e-02 5.46e-01 9.01e-01
Metabolism-of-amino-acids-and-derivatives 251 1.95e-02 9.11e-02 0.09870 -0.049200 -8.56e-02 1.82e-01 2.02e-02
Signaling-by-Activin 10 8.70e-01 9.18e-01 0.09850 -0.026100 9.49e-02 8.86e-01 6.03e-01
Signaling-by-NTRKs 107 2.40e-01 4.71e-01 0.09840 -0.086600 4.66e-02 1.22e-01 4.05e-01
RET-signaling 31 6.43e-01 7.91e-01 0.09830 -0.097600 1.18e-02 3.47e-01 9.10e-01
TNFR1-induced-proapoptotic-signaling 12 8.43e-01 9.02e-01 0.09800 0.011400 -9.74e-02 9.46e-01 5.59e-01
Long-term-potentiation 13 8.24e-01 8.90e-01 0.09790 0.011900 9.72e-02 9.41e-01 5.44e-01
Estrogen-dependent-gene-expression 78 3.10e-01 5.39e-01 0.09780 -0.095300 -2.18e-02 1.46e-01 7.40e-01
Activation-of-SMO 14 8.32e-01 8.95e-01 0.09760 0.084900 -4.82e-02 5.82e-01 7.55e-01
G2/M-DNA-damage-checkpoint 43 5.49e-01 7.23e-01 0.09750 0.096600 -1.30e-02 2.73e-01 8.83e-01
NOTCH4-Intracellular-Domain-Regulates-Transcription 19 7.58e-01 8.50e-01 0.09730 -0.096900 -8.75e-03 4.65e-01 9.47e-01
Rev-mediated-nuclear-export-of-HIV-RNA 31 6.65e-01 8.03e-01 0.09720 -0.087300 4.26e-02 4.00e-01 6.82e-01
Cell-cell-junction-organization 25 7.14e-01 8.28e-01 0.09690 -0.093500 2.55e-02 4.19e-01 8.26e-01
Mismatch-repair-(MMR)-directed-by-MSH2:MSH3-(MutSbeta) 12 8.57e-01 9.10e-01 0.09690 0.078600 -5.66e-02 6.37e-01 7.34e-01
Regulation-of-RUNX1-Expression-and-Activity 17 7.86e-01 8.66e-01 0.09680 0.000709 -9.68e-02 9.96e-01 4.90e-01
tRNA-processing 110 2.33e-01 4.60e-01 0.09680 -0.092500 2.85e-02 9.46e-02 6.06e-01
Adaptive-Immune-System 502 2.11e-03 1.63e-02 0.09660 -0.078800 5.59e-02 2.75e-03 3.38e-02
Transport-of-Mature-Transcript-to-Cytoplasm 75 3.21e-01 5.51e-01 0.09660 -0.086400 -4.32e-02 1.96e-01 5.19e-01
Platelet-calcium-homeostasis 18 7.77e-01 8.61e-01 0.09600 -0.002310 -9.60e-02 9.86e-01 4.81e-01
Inactivation,-recovery-and-regulation-of-the-phototransduction-cascade 11 8.63e-01 9.14e-01 0.09600 -0.020000 9.39e-02 9.09e-01 5.90e-01
The-phototransduction-cascade 11 8.63e-01 9.14e-01 0.09600 -0.020000 9.39e-02 9.09e-01 5.90e-01
Deadenylation-of-mRNA 21 7.43e-01 8.40e-01 0.09560 0.011800 9.49e-02 9.26e-01 4.52e-01
Toll-Like-Receptor-4-(TLR4)-Cascade 105 2.36e-01 4.66e-01 0.09550 0.001930 9.55e-02 9.73e-01 9.16e-02
GPCR-ligand-binding 97 2.50e-01 4.81e-01 0.09520 -0.025000 -9.18e-02 6.71e-01 1.19e-01
APC/C:Cdc20-mediated-degradation-of-Cyclin-B 18 7.67e-01 8.55e-01 0.09510 -0.085600 -4.15e-02 5.30e-01 7.61e-01
Programmed-Cell-Death 144 1.20e-01 3.12e-01 0.09450 -0.070400 -6.31e-02 1.46e-01 1.93e-01
Oncogene-Induced-Senescence 28 7.12e-01 8.28e-01 0.09440 0.072900 -6.00e-02 5.04e-01 5.83e-01
SUMOylation-of-transcription-cofactors 41 5.67e-01 7.31e-01 0.09440 0.014200 9.33e-02 8.75e-01 3.02e-01
Syndecan-interactions 18 7.69e-01 8.55e-01 0.09390 -0.054300 -7.65e-02 6.90e-01 5.74e-01
Viral-Messenger-RNA-Synthesis 40 5.69e-01 7.31e-01 0.09380 -0.089000 -2.98e-02 3.30e-01 7.45e-01
Unfolded-Protein-Response-(UPR) 83 3.35e-01 5.61e-01 0.09350 -0.000585 -9.35e-02 9.93e-01 1.42e-01
Budding-and-maturation-of-HIV-virion 24 7.26e-01 8.35e-01 0.09340 -0.093200 -5.17e-03 4.29e-01 9.65e-01
Metal-ion-SLC-transporters 17 8.13e-01 8.85e-01 0.09310 -0.037600 8.52e-02 7.88e-01 5.43e-01
APC-Cdc20-mediated-degradation-of-Nek2A 20 7.51e-01 8.44e-01 0.09290 -0.074400 -5.56e-02 5.65e-01 6.67e-01
RHO-GTPase-Effectors 178 8.42e-02 2.53e-01 0.09210 -0.058500 -7.11e-02 1.80e-01 1.03e-01
Transcription-Coupled-Nucleotide-Excision-Repair-(TC-NER) 75 3.49e-01 5.65e-01 0.09210 -0.069000 -6.10e-02 3.02e-01 3.62e-01
Spry-regulation-of-FGF-signaling 15 8.13e-01 8.85e-01 0.09190 0.082400 4.06e-02 5.81e-01 7.85e-01
Regulation-of-PTEN-gene-transcription 57 4.72e-01 6.63e-01 0.09140 0.020800 8.90e-02 7.86e-01 2.45e-01
HDR-through-Homologous-Recombination-(HRR) 46 5.95e-01 7.52e-01 0.09120 0.058600 -6.98e-02 4.92e-01 4.13e-01
Stimuli-sensing-channels 47 5.37e-01 7.15e-01 0.09090 0.086400 2.83e-02 3.06e-01 7.38e-01
Alpha-protein-kinase-1-signaling-pathway 10 8.95e-01 9.31e-01 0.08990 0.073300 -5.20e-02 6.88e-01 7.76e-01
Postmitotic-nuclear-pore-complex-(NPC)-reformation 26 7.09e-01 8.28e-01 0.08970 0.046700 7.66e-02 6.81e-01 4.99e-01
Mitotic-G2-G2/M-phases 157 1.27e-01 3.25e-01 0.08940 -0.068500 -5.75e-02 1.40e-01 2.15e-01
Intraflagellar-transport 34 6.69e-01 8.03e-01 0.08940 -0.009220 8.89e-02 9.26e-01 3.70e-01
SLC-mediated-transmembrane-transport 123 2.03e-01 4.16e-01 0.08920 0.076600 4.58e-02 1.43e-01 3.82e-01
Signaling-by-WNT 209 8.45e-02 2.53e-01 0.08910 -0.089100 8.24e-05 2.70e-02 9.98e-01
TRAF6-mediated-NF-kB-activation 19 7.92e-01 8.71e-01 0.08900 0.088500 9.85e-03 5.05e-01 9.41e-01
Rab-regulation-of-trafficking 109 3.11e-01 5.39e-01 0.08880 -0.051200 7.25e-02 3.57e-01 1.92e-01
G2/M-Transition 156 1.33e-01 3.31e-01 0.08860 -0.066100 -5.90e-02 1.55e-01 2.05e-01
Resolution-of-AP-sites-via-the-multiple-nucleotide-patch-replacement-pathway 23 7.82e-01 8.64e-01 0.08850 0.052900 -7.10e-02 6.61e-01 5.56e-01
Signaling-by-Receptor-Tyrosine-Kinases 370 9.56e-03 5.38e-02 0.08840 -0.071800 -5.17e-02 1.86e-02 9.02e-02
FOXO-mediated-transcription-of-cell-cycle-genes 15 8.25e-01 8.90e-01 0.08840 0.043400 7.70e-02 7.71e-01 6.06e-01
Interactions-of-Rev-with-host-cellular-proteins 32 7.15e-01 8.28e-01 0.08790 -0.063800 6.05e-02 5.33e-01 5.54e-01
Downregulation-of-TGF-beta-receptor-signaling 25 7.31e-01 8.38e-01 0.08790 -0.080000 -3.63e-02 4.89e-01 7.53e-01
Cytochrome-P450---arranged-by-substrate-type 20 8.05e-01 8.79e-01 0.08750 0.082700 -2.86e-02 5.22e-01 8.25e-01
Regulation-of-glycolysis-by-fructose-2,6-bisphosphate-metabolism 11 8.84e-01 9.25e-01 0.08740 -0.014500 8.62e-02 9.34e-01 6.21e-01
Mitotic-Prophase 71 4.46e-01 6.44e-01 0.08670 0.002190 8.67e-02 9.75e-01 2.07e-01
Membrane-Trafficking 490 3.35e-03 2.40e-02 0.08660 0.031200 8.08e-02 2.42e-01 2.41e-03
Mitotic-Anaphase 178 1.32e-01 3.29e-01 0.08660 -0.086200 -8.18e-03 4.81e-02 8.51e-01
Mitotic-Metaphase-and-Anaphase 178 1.32e-01 3.29e-01 0.08660 -0.086200 -8.18e-03 4.81e-02 8.51e-01
p75-NTR-receptor-mediated-signalling 80 4.37e-01 6.38e-01 0.08610 0.033700 -7.92e-02 6.02e-01 2.22e-01
Regulation-of-TP53-Activity-through-Acetylation 29 7.11e-01 8.28e-01 0.08590 0.023900 8.25e-02 8.24e-01 4.42e-01
Recycling-pathway-of-L1 24 7.46e-01 8.40e-01 0.08580 -0.053200 -6.73e-02 6.52e-01 5.68e-01
Toll-like-Receptor-Cascades 119 2.56e-01 4.85e-01 0.08580 0.015900 8.43e-02 7.65e-01 1.13e-01
TP53-Regulates-Metabolic-Genes 78 4.31e-01 6.33e-01 0.08530 -0.085100 6.48e-03 1.95e-01 9.21e-01
Signaling-by-TGF-beta-Receptor-Complex 67 5.15e-01 7.00e-01 0.08510 -0.070900 4.71e-02 3.16e-01 5.05e-01
Neurotransmitter-receptors-and-postsynaptic-signal-transmission 100 3.09e-01 5.38e-01 0.08500 0.075800 3.85e-02 1.91e-01 5.06e-01
Chaperonin-mediated-protein-folding 68 4.95e-01 6.85e-01 0.08500 0.022600 -8.20e-02 7.48e-01 2.43e-01
Signaling-by-NOTCH1 67 4.79e-01 6.70e-01 0.08470 -0.006740 -8.44e-02 9.24e-01 2.33e-01
Diseases-associated-with-the-TLR-signaling-cascade 18 8.21e-01 8.88e-01 0.08460 0.084400 6.12e-03 5.36e-01 9.64e-01
Diseases-of-Immune-System 18 8.21e-01 8.88e-01 0.08460 0.084400 6.12e-03 5.36e-01 9.64e-01
Ephrin-signaling 13 8.70e-01 9.18e-01 0.08460 -0.084400 5.00e-03 5.98e-01 9.75e-01
Apoptosis 141 1.91e-01 4.05e-01 0.08450 -0.065900 -5.28e-02 1.78e-01 2.80e-01
Diseases-of-signal-transduction-by-growth-factor-receptors-and-second-messengers 310 4.80e-02 1.71e-01 0.08450 -0.078300 3.15e-02 1.84e-02 3.42e-01
L1CAM-interactions 70 4.95e-01 6.85e-01 0.08440 -0.079400 2.85e-02 2.51e-01 6.80e-01
HDACs-deacetylate-histones 31 7.05e-01 8.28e-01 0.08440 0.022100 8.14e-02 8.31e-01 4.33e-01
Nuclear-Envelope-Breakdown 44 6.52e-01 7.97e-01 0.08420 -0.045900 7.06e-02 5.98e-01 4.19e-01
Cilium-Assembly 158 1.73e-01 3.80e-01 0.08420 0.081300 2.19e-02 7.88e-02 6.36e-01
Protein-folding 73 4.98e-01 6.87e-01 0.08370 0.049200 -6.78e-02 4.68e-01 3.17e-01
Formation-of-RNA-Pol-II-elongation-complex 53 5.53e-01 7.23e-01 0.08360 -0.079300 -2.65e-02 3.18e-01 7.39e-01
RNA-Polymerase-II-Transcription-Elongation 53 5.53e-01 7.23e-01 0.08360 -0.079300 -2.65e-02 3.18e-01 7.39e-01
Signaling-by-FGFR1 34 7.27e-01 8.35e-01 0.08260 -0.043800 7.00e-02 6.59e-01 4.80e-01
Post-translational-protein-modification 1020 8.31e-05 1.53e-03 0.08230 -0.008060 8.19e-02 6.70e-01 1.46e-05
IRAK2-mediated-activation-of-TAK1-complex-upon-TLR7/8-or-9-stimulation 12 8.79e-01 9.21e-01 0.08200 -0.078700 -2.32e-02 6.37e-01 8.90e-01
TRAF6-mediated-induction-of-TAK1-complex-within-TLR4-complex 12 8.79e-01 9.21e-01 0.08200 -0.078700 -2.32e-02 6.37e-01 8.90e-01
Gamma-carboxylation,-hypusine-formation-and-arylsulfatase-activation 23 8.02e-01 8.77e-01 0.08180 -0.022100 7.88e-02 8.55e-01 5.13e-01
IRF3-mediated-induction-of-type-I-IFN 10 9.11e-01 9.40e-01 0.08170 0.035800 -7.34e-02 8.44e-01 6.88e-01
tRNA-processing-in-the-nucleus 53 5.60e-01 7.26e-01 0.08150 -0.067900 -4.50e-02 3.93e-01 5.71e-01
Constitutive-Signaling-by-EGFRvIII 15 8.50e-01 9.04e-01 0.08130 0.036200 7.28e-02 8.08e-01 6.25e-01
Signaling-by-EGFRvIII-in-Cancer 15 8.50e-01 9.04e-01 0.08130 0.036200 7.28e-02 8.08e-01 6.25e-01
Activation-of-AMPK-downstream-of-NMDARs 10 9.13e-01 9.41e-01 0.08080 0.033600 -7.34e-02 8.54e-01 6.88e-01
Mitotic-G1-phase-and-G1/S-transition 118 2.83e-01 5.10e-01 0.08070 -0.049200 -6.40e-02 3.57e-01 2.31e-01
HIV-Transcription-Initiation 44 6.74e-01 8.03e-01 0.08070 0.040100 -7.00e-02 6.46e-01 4.22e-01
RNA-Polymerase-II-HIV-Promoter-Escape 44 6.74e-01 8.03e-01 0.08070 0.040100 -7.00e-02 6.46e-01 4.22e-01
RNA-Polymerase-II-Promoter-Escape 44 6.74e-01 8.03e-01 0.08070 0.040100 -7.00e-02 6.46e-01 4.22e-01
RNA-Polymerase-II-Transcription-Initiation 44 6.74e-01 8.03e-01 0.08070 0.040100 -7.00e-02 6.46e-01 4.22e-01
RNA-Polymerase-II-Transcription-Initiation-And-Promoter-Clearance 44 6.74e-01 8.03e-01 0.08070 0.040100 -7.00e-02 6.46e-01 4.22e-01
RNA-Polymerase-II-Transcription-Pre-Initiation-And-Promoter-Opening 44 6.74e-01 8.03e-01 0.08070 0.040100 -7.00e-02 6.46e-01 4.22e-01
Transport-of-Mature-mRNA-derived-from-an-Intron-Containing-Transcript 67 4.89e-01 6.81e-01 0.08040 -0.063900 -4.88e-02 3.67e-01 4.90e-01
Transport-of-the-SLBP-Dependant-Mature-mRNA 32 7.54e-01 8.46e-01 0.08030 -0.064700 4.77e-02 5.27e-01 6.41e-01
Ion-channel-transport 99 3.59e-01 5.72e-01 0.08030 0.074800 2.92e-02 1.99e-01 6.17e-01
Signaling-by-EGFR 41 6.78e-01 8.07e-01 0.08010 -0.079600 9.23e-03 3.78e-01 9.19e-01
RAB-GEFs-exchange-GTP-for-GDP-on-RABs 80 5.00e-01 6.89e-01 0.07990 -0.062300 5.01e-02 3.36e-01 4.39e-01
Transcriptional-regulation-of-white-adipocyte-differentiation 72 5.38e-01 7.16e-01 0.07970 0.057100 -5.56e-02 4.03e-01 4.15e-01
Signaling-by-FGFR 61 5.33e-01 7.12e-01 0.07970 -0.035200 -7.15e-02 6.35e-01 3.35e-01
Glycolysis 58 6.08e-01 7.66e-01 0.07950 -0.060000 5.22e-02 4.30e-01 4.92e-01
Signaling-by-BRAF-and-RAF-fusions 55 5.66e-01 7.31e-01 0.07950 0.068500 4.03e-02 3.80e-01 6.05e-01
ECM-proteoglycans 35 6.99e-01 8.27e-01 0.07950 -0.030500 -7.34e-02 7.55e-01 4.53e-01
BBSome-mediated-cargo-targeting-to-cilium 18 8.30e-01 8.94e-01 0.07890 -0.060900 -5.02e-02 6.55e-01 7.13e-01
Inositol-phosphate-metabolism 39 6.73e-01 8.03e-01 0.07880 0.069900 3.64e-02 4.51e-01 6.94e-01
DNA-Repair 234 1.09e-01 2.94e-01 0.07870 -0.077600 -1.28e-02 4.17e-02 7.36e-01
RUNX1-interacts-with-co-factors-whose-precise-effect-on-RUNX1-targets-is-not-known 36 7.34e-01 8.39e-01 0.07800 -0.027500 7.30e-02 7.76e-01 4.49e-01
HS-GAG-biosynthesis 18 8.35e-01 8.96e-01 0.07780 -0.061700 -4.73e-02 6.50e-01 7.28e-01
Nuclear-Events-(kinase-and-transcription-factor-activation) 47 6.80e-01 8.08e-01 0.07770 -0.056400 5.34e-02 5.04e-01 5.26e-01
NOTCH3-Intracellular-Domain-Regulates-Transcription 19 8.48e-01 9.04e-01 0.07750 -0.075500 1.77e-02 5.69e-01 8.94e-01
Netrin-1-signaling 35 7.06e-01 8.28e-01 0.07740 -0.059100 -4.99e-02 5.45e-01 6.10e-01
IKK-complex-recruitment-mediated-by-RIP1 18 8.41e-01 9.01e-01 0.07730 -0.027900 -7.21e-02 8.38e-01 5.97e-01
Transport-of-small-molecules 431 3.05e-02 1.26e-01 0.07720 -0.028600 7.17e-02 3.12e-01 1.14e-02
Organelle-biogenesis-and-maintenance 229 1.36e-01 3.31e-01 0.07680 -0.001270 7.68e-02 9.74e-01 4.63e-02
FCERI-mediated-MAPK-activation 25 7.97e-01 8.74e-01 0.07670 0.007340 7.63e-02 9.49e-01 5.09e-01
Cargo-recognition-for-clathrin-mediated-endocytosis 76 5.44e-01 7.21e-01 0.07650 -0.041700 6.41e-02 5.30e-01 3.34e-01
Signaling-by-GPCR 316 7.90e-02 2.43e-01 0.07580 0.020400 -7.30e-02 5.35e-01 2.66e-02
TP53-Regulates-Transcription-of-Cell-Cycle-Genes 36 7.38e-01 8.40e-01 0.07550 0.007120 -7.51e-02 9.41e-01 4.36e-01
Translesion-synthesis-by-POLI 14 8.79e-01 9.21e-01 0.07460 0.042700 6.12e-02 7.82e-01 6.92e-01
Translesion-synthesis-by-REV1 14 8.79e-01 9.21e-01 0.07460 0.042700 6.12e-02 7.82e-01 6.92e-01
SUMOylation-of-DNA-replication-proteins 37 7.14e-01 8.28e-01 0.07440 0.063900 3.81e-02 5.02e-01 6.89e-01
Senescence-Associated-Secretory-Phenotype-(SASP) 41 7.33e-01 8.38e-01 0.07420 0.037500 -6.41e-02 6.78e-01 4.78e-01
G1/S-Transition 105 3.92e-01 6.01e-01 0.07350 -0.046500 -5.69e-02 4.11e-01 3.15e-01
Nucleotide-Excision-Repair 106 3.90e-01 5.99e-01 0.07350 -0.060400 -4.19e-02 2.84e-01 4.57e-01
Post-translational-modification:-synthesis-of-GPI-anchored-proteins 43 7.02e-01 8.28e-01 0.07330 -0.005400 -7.31e-02 9.51e-01 4.07e-01
MET-promotes-cell-motility 23 8.46e-01 9.03e-01 0.07300 -0.043500 5.86e-02 7.18e-01 6.27e-01
Signaling-by-NTRK1-(TRKA) 93 5.01e-01 6.90e-01 0.07300 -0.066900 2.92e-02 2.66e-01 6.27e-01
Regulation-of-TP53-Degradation 31 7.70e-01 8.55e-01 0.07200 -0.031200 -6.49e-02 7.64e-01 5.32e-01
Regulation-of-TP53-Expression-and-Degradation 31 7.70e-01 8.55e-01 0.07200 -0.031200 -6.49e-02 7.64e-01 5.32e-01
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides 56 6.60e-01 8.03e-01 0.07200 0.069400 -1.89e-02 3.69e-01 8.07e-01
Mitotic-Prometaphase 140 3.27e-01 5.55e-01 0.07180 0.070700 1.28e-02 1.50e-01 7.95e-01
Ion-transport-by-P-type-ATPases 36 7.40e-01 8.40e-01 0.07160 0.063600 3.29e-02 5.10e-01 7.33e-01
Metabolism-of-vitamins-and-cofactors 132 3.44e-01 5.64e-01 0.07120 0.024300 6.69e-02 6.31e-01 1.86e-01
Cytokine-Signaling-in-Immune-system 541 1.30e-02 6.75e-02 0.07100 -0.049100 -5.14e-02 5.34e-02 4.32e-02
Antigen-Presentation:-Folding,-assembly-and-peptide-loading-of-class-I-MHC 17 8.73e-01 9.19e-01 0.06940 0.047900 5.03e-02 7.33e-01 7.20e-01
Signaling-by-FGFR-in-disease 49 7.26e-01 8.35e-01 0.06930 -0.042300 5.49e-02 6.09e-01 5.07e-01
Asparagine-N-linked-glycosylation 241 1.56e-01 3.62e-01 0.06920 0.060800 3.30e-02 1.05e-01 3.79e-01
Cargo-trafficking-to-the-periciliary-membrane 42 7.49e-01 8.42e-01 0.06900 -0.014000 6.75e-02 8.75e-01 4.49e-01
Signaling-by-FGFR2 55 6.48e-01 7.94e-01 0.06890 -0.047800 -4.96e-02 5.40e-01 5.25e-01
Constitutive-Signaling-by-NOTCH1-HD+PEST-Domain-Mutants 55 6.64e-01 8.03e-01 0.06800 -0.063500 -2.44e-02 4.16e-01 7.55e-01
Constitutive-Signaling-by-NOTCH1-PEST-Domain-Mutants 55 6.64e-01 8.03e-01 0.06800 -0.063500 -2.44e-02 4.16e-01 7.55e-01
Signaling-by-NOTCH1-HD+PEST-Domain-Mutants-in-Cancer 55 6.64e-01 8.03e-01 0.06800 -0.063500 -2.44e-02 4.16e-01 7.55e-01
Signaling-by-NOTCH1-PEST-Domain-Mutants-in-Cancer 55 6.64e-01 8.03e-01 0.06800 -0.063500 -2.44e-02 4.16e-01 7.55e-01
Signaling-by-NOTCH1-in-Cancer 55 6.64e-01 8.03e-01 0.06800 -0.063500 -2.44e-02 4.16e-01 7.55e-01
Translesion-synthesis-by-Y-family-DNA-polymerases-bypasses-lesions-on-DNA-template 33 7.78e-01 8.61e-01 0.06780 -0.052500 -4.29e-02 6.02e-01 6.70e-01
CTLA4-inhibitory-signaling 18 8.75e-01 9.20e-01 0.06680 -0.045200 -4.93e-02 7.40e-01 7.18e-01
Chromosome-Maintenance 46 7.40e-01 8.40e-01 0.06630 0.004180 -6.62e-02 9.61e-01 4.38e-01
Costimulation-by-the-CD28-family 46 7.54e-01 8.46e-01 0.06510 -0.063800 1.33e-02 4.55e-01 8.76e-01
FCGR3A-mediated-IL10-synthesis 29 8.43e-01 9.02e-01 0.06510 0.030700 -5.74e-02 7.75e-01 5.93e-01
Diseases-associated-with-N-glycosylation-of-proteins 16 9.14e-01 9.41e-01 0.06440 0.044400 -4.67e-02 7.59e-01 7.46e-01
ESR-mediated-signaling 134 4.22e-01 6.26e-01 0.06310 -0.028600 -5.62e-02 5.69e-01 2.62e-01
Signaling-by-NTRK2-(TRKB) 20 8.97e-01 9.31e-01 0.06290 -0.031700 5.43e-02 8.06e-01 6.74e-01
Nuclear-signaling-by-ERBB4 23 8.84e-01 9.25e-01 0.06280 0.046300 -4.25e-02 7.01e-01 7.24e-01
Signaling-by-TGF-beta-family-members 83 6.42e-01 7.91e-01 0.06270 -0.049700 3.82e-02 4.35e-01 5.48e-01
NOTCH1-Intracellular-Domain-Regulates-Transcription 45 7.61e-01 8.50e-01 0.06180 0.018200 5.90e-02 8.33e-01 4.94e-01
Vesicle-mediated-transport 515 5.01e-02 1.76e-01 0.06170 0.017400 5.92e-02 5.02e-01 2.29e-02
Innate-Immune-System 661 2.23e-02 9.99e-02 0.06160 -0.018600 -5.88e-02 4.20e-01 1.10e-02
Neutrophil-degranulation 322 1.81e-01 3.91e-01 0.06050 0.005210 -6.03e-02 8.73e-01 6.45e-02
Cellular-Senescence 112 5.10e-01 6.98e-01 0.06040 0.036400 4.82e-02 5.06e-01 3.79e-01
SUMOylation-of-RNA-binding-proteins 43 7.72e-01 8.56e-01 0.06040 0.049500 3.46e-02 5.74e-01 6.95e-01
Activation-of-BAD-and-translocation-to-mitochondria 12 9.30e-01 9.51e-01 0.06040 -0.044500 -4.08e-02 7.90e-01 8.07e-01
Constitutive-Signaling-by-Ligand-Responsive-EGFR-Cancer-Variants 18 8.99e-01 9.32e-01 0.06020 -0.054300 -2.61e-02 6.90e-01 8.48e-01
Signaling-by-Ligand-Responsive-EGFR-Variants-in-Cancer 18 8.99e-01 9.32e-01 0.06020 -0.054300 -2.61e-02 6.90e-01 8.48e-01
Gene-expression-(Transcription) 975 1.26e-02 6.62e-02 0.05930 -0.052600 2.74e-02 6.45e-03 1.55e-01
Depolymerisation-of-the-Nuclear-Lamina 12 9.34e-01 9.54e-01 0.05870 -0.046500 -3.58e-02 7.80e-01 8.30e-01
Deregulated-CDK5-triggers-multiple-neurodegenerative-pathways-in-Alzheimer's-disease-models 18 9.04e-01 9.35e-01 0.05820 0.044600 3.74e-02 7.43e-01 7.84e-01
Neurodegenerative-Diseases 18 9.04e-01 9.35e-01 0.05820 0.044600 3.74e-02 7.43e-01 7.84e-01
Recognition-of-DNA-damage-by-PCNA-containing-replication-complex 25 8.91e-01 9.29e-01 0.05790 0.028200 -5.06e-02 8.07e-01 6.62e-01
Inhibition-of-replication-initiation-of-damaged-DNA-by-RB1/E2F1 10 9.54e-01 9.68e-01 0.05760 0.019500 -5.42e-02 9.15e-01 7.66e-01
DDX58/IFIH1-mediated-induction-of-interferon-alpha/beta 54 7.45e-01 8.40e-01 0.05730 -0.040300 -4.08e-02 6.09e-01 6.04e-01
RAF-activation 30 8.67e-01 9.17e-01 0.05720 -0.010700 5.62e-02 9.20e-01 5.95e-01
RHO-GTPases-Activate-Formins 83 6.66e-01 8.03e-01 0.05710 -0.057100 2.20e-04 3.69e-01 9.97e-01
Signaling-by-ERBB2 41 8.17e-01 8.88e-01 0.05690 -0.002270 -5.68e-02 9.80e-01 5.29e-01
Rho-GTPase-cycle 111 6.14e-01 7.72e-01 0.05660 0.049300 -2.78e-02 3.71e-01 6.14e-01
Interferon-gamma-signaling 51 7.90e-01 8.70e-01 0.05600 0.006760 -5.56e-02 9.33e-01 4.92e-01
Signalling-to-ERKs 30 8.63e-01 9.14e-01 0.05530 0.051900 1.91e-02 6.23e-01 8.57e-01
Phosphorylation-of-the-APC/C 15 9.35e-01 9.55e-01 0.05440 -0.001400 5.44e-02 9.93e-01 7.15e-01
Regulation-of-TP53-Activity 131 5.68e-01 7.31e-01 0.05440 -0.006680 5.39e-02 8.95e-01 2.88e-01
VEGFA-VEGFR2-Pathway 83 6.72e-01 8.03e-01 0.05390 -0.032100 -4.33e-02 6.14e-01 4.96e-01
Muscle-contraction 126 5.56e-01 7.25e-01 0.05350 0.046300 2.67e-02 3.70e-01 6.06e-01
DNA-Double-Strand-Break-Repair 102 6.40e-01 7.89e-01 0.05310 -0.008850 -5.23e-02 8.77e-01 3.62e-01
Insulin-receptor-recycling 19 9.26e-01 9.48e-01 0.05310 0.051100 -1.45e-02 7.00e-01 9.13e-01
E2F-mediated-regulation-of-DNA-replication 16 9.29e-01 9.50e-01 0.05270 0.042200 3.16e-02 7.70e-01 8.27e-01
Iron-uptake-and-transport 43 8.30e-01 8.94e-01 0.05260 0.010200 5.16e-02 9.08e-01 5.59e-01
CLEC7A-(Dectin-1)-induces-NFAT-activation 11 9.59e-01 9.72e-01 0.05250 -0.022800 4.74e-02 8.96e-01 7.86e-01
S-Phase 134 5.59e-01 7.26e-01 0.05140 -0.040200 -3.20e-02 4.23e-01 5.23e-01
HDR-through-Single-Strand-Annealing-(SSA) 28 8.92e-01 9.30e-01 0.05100 0.050200 9.00e-03 6.46e-01 9.34e-01
Metabolism 1462 5.62e-03 3.63e-02 0.05040 0.012900 4.87e-02 4.25e-01 2.50e-03
SLC-transporter-disorders 55 7.94e-01 8.71e-01 0.05040 0.040300 3.03e-02 6.06e-01 6.98e-01
Cell-Cycle-Checkpoints 185 5.07e-01 6.94e-01 0.04910 -0.048800 -5.25e-03 2.54e-01 9.02e-01
Metabolism-of-carbohydrates 210 4.64e-01 6.58e-01 0.04890 0.006780 4.84e-02 8.66e-01 2.28e-01
SMAD2/SMAD3:SMAD4-heterotrimer-regulates-transcription 28 9.11e-01 9.40e-01 0.04810 0.046900 -1.05e-02 6.68e-01 9.23e-01
Signaling-by-Rho-GTPases 280 3.73e-01 5.85e-01 0.04770 -0.010900 -4.65e-02 7.55e-01 1.83e-01
Interleukin-1-family-signaling 108 7.21e-01 8.33e-01 0.04720 -0.039700 2.55e-02 4.77e-01 6.48e-01
Nuclear-Envelope-(NE)-Reassembly 61 8.32e-01 8.95e-01 0.04630 0.017400 -4.29e-02 8.14e-01 5.62e-01
Conversion-from-APC/C:Cdc20-to-APC/C:Cdh1-in-late-anaphase 17 9.41e-01 9.59e-01 0.04630 0.029700 3.55e-02 8.32e-01 8.00e-01
Clathrin-mediated-endocytosis 110 7.23e-01 8.34e-01 0.04610 -0.042200 1.86e-02 4.46e-01 7.37e-01
CD28-co-stimulation 27 9.24e-01 9.48e-01 0.04600 -0.022200 4.03e-02 8.42e-01 7.17e-01
Diseases-of-programmed-cell-death 19 9.44e-01 9.60e-01 0.04420 0.043800 6.01e-03 7.41e-01 9.64e-01
Disease 951 6.37e-02 2.08e-01 0.04350 -0.026900 -3.42e-02 1.68e-01 7.97e-02
Signal-Transduction 1460 1.80e-02 8.56e-02 0.04340 -0.031900 -2.94e-02 4.80e-02 6.81e-02
Generic-Transcription-Pathway 753 1.65e-01 3.70e-01 0.04320 -0.033300 2.76e-02 1.26e-01 2.05e-01
RNA-polymerase-II-transcribes-snRNA-genes 68 8.21e-01 8.88e-01 0.04310 -0.042300 -8.02e-03 5.47e-01 9.09e-01
Immune-System 1299 3.19e-02 1.30e-01 0.04230 -0.033600 -2.57e-02 4.75e-02 1.30e-01
RNA-Polymerase-II-Transcription 864 1.50e-01 3.51e-01 0.04150 -0.034300 2.34e-02 9.26e-02 2.52e-01
Formation-of-Incision-Complex-in-GG-NER 41 9.08e-01 9.39e-01 0.04060 0.038700 -1.22e-02 6.68e-01 8.92e-01
Late-Phase-of-HIV-Life-Cycle 121 7.40e-01 8.40e-01 0.04000 -0.039400 -7.18e-03 4.56e-01 8.92e-01
Signaling-by-Interleukins 301 4.69e-01 6.61e-01 0.03940 -0.023900 -3.14e-02 4.79e-01 3.52e-01
Interleukin-10-signaling 12 9.74e-01 9.80e-01 0.03930 0.009710 -3.81e-02 9.54e-01 8.19e-01
Oncogenic-MAPK-signaling 62 8.68e-01 9.17e-01 0.03870 0.038700 1.86e-03 5.99e-01 9.80e-01
Signaling-by-Non-Receptor-Tyrosine-Kinases 43 9.24e-01 9.48e-01 0.03660 0.028800 -2.27e-02 7.44e-01 7.97e-01
Signaling-by-PTK6 43 9.24e-01 9.48e-01 0.03660 0.028800 -2.27e-02 7.44e-01 7.97e-01
G-alpha-(12/13)-signalling-events 60 8.94e-01 9.30e-01 0.03600 0.007710 -3.51e-02 9.18e-01 6.38e-01
Transferrin-endocytosis-and-recycling 22 9.60e-01 9.72e-01 0.03570 0.035300 -5.58e-03 7.75e-01 9.64e-01
M-Phase 280 6.21e-01 7.75e-01 0.03520 -0.032200 1.44e-02 3.57e-01 6.81e-01
DAP12-signaling 19 9.70e-01 9.78e-01 0.03410 0.021300 -2.66e-02 8.73e-01 8.41e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE 64 9.01e-01 9.34e-01 0.03400 0.012100 -3.17e-02 8.67e-01 6.61e-01
Diseases-of-metabolism 167 7.86e-01 8.66e-01 0.03270 0.021800 -2.44e-02 6.28e-01 5.87e-01
ERCC6-(CSB)-and-EHMT2-(G9a)-positively-regulate-rRNA-expression 15 9.75e-01 9.81e-01 0.03260 -0.032000 -6.55e-03 8.30e-01 9.65e-01
Transcription-of-the-HIV-genome 63 9.14e-01 9.41e-01 0.03200 0.012400 -2.95e-02 8.65e-01 6.86e-01
XBP1(S)-activates-chaperone-genes 46 9.37e-01 9.56e-01 0.03180 0.028500 -1.40e-02 7.38e-01 8.70e-01
Regulation-of-TP53-Activity-through-Phosphorylation 73 8.87e-01 9.26e-01 0.03150 0.021900 2.27e-02 7.47e-01 7.38e-01
Keratan-sulfate/keratin-metabolism 23 9.69e-01 9.78e-01 0.03070 -0.029700 7.92e-03 8.06e-01 9.48e-01
Downstream-signal-transduction 28 9.63e-01 9.74e-01 0.02990 0.029900 -1.21e-04 7.85e-01 9.99e-01
NGF-stimulated-transcription 26 9.69e-01 9.78e-01 0.02960 -0.025200 1.57e-02 8.24e-01 8.90e-01
Amino-acids-regulate-mTORC1 47 9.48e-01 9.63e-01 0.02840 -0.026500 1.03e-02 7.53e-01 9.03e-01
RNA-Polymerase-II-Pre-transcription-Events 73 9.26e-01 9.48e-01 0.02790 -0.022600 1.63e-02 7.39e-01 8.10e-01
Metabolism-of-proteins 1475 2.42e-01 4.72e-01 0.02760 -0.026700 7.32e-03 9.70e-02 6.49e-01
Death-Receptor-Signalling 116 8.87e-01 9.26e-01 0.02760 0.022900 -1.54e-02 6.71e-01 7.75e-01
Signaling-by-MET 54 9.47e-01 9.62e-01 0.02720 -0.016700 2.15e-02 8.32e-01 7.85e-01
Metabolism-of-nucleotides 75 9.22e-01 9.48e-01 0.02690 0.000740 -2.69e-02 9.91e-01 6.87e-01
Detoxification-of-Reactive-Oxygen-Species 30 9.70e-01 9.78e-01 0.02690 0.013400 -2.33e-02 8.99e-01 8.25e-01
Inactivation-of-APC/C-via-direct-inhibition-of-the-APC/C-complex 17 9.82e-01 9.85e-01 0.02660 0.001850 2.65e-02 9.89e-01 8.50e-01
Inhibition-of-the-proteolytic-activity-of-APC/C-required-for-the-onset-of-anaphase-by-mitotic-spindle-checkpoint-components 17 9.82e-01 9.85e-01 0.02660 0.001850 2.65e-02 9.89e-01 8.50e-01
HIV-Life-Cycle 132 8.78e-01 9.21e-01 0.02620 -0.025700 5.18e-03 6.12e-01 9.18e-01
Transcriptional-Regulation-by-TP53 297 8.06e-01 8.80e-01 0.02230 -0.022200 1.32e-03 5.12e-01 9.69e-01
Global-Genome-Nucleotide-Excision-Repair-(GG-NER) 80 9.42e-01 9.59e-01 0.02120 -0.015600 -1.44e-02 8.10e-01 8.24e-01
Signaling-by-Nuclear-Receptors 186 8.94e-01 9.30e-01 0.02030 -0.002640 2.02e-02 9.51e-01 6.36e-01
IRE1alpha-activates-chaperones 48 9.70e-01 9.78e-01 0.02000 0.018600 7.10e-03 8.23e-01 9.32e-01
NRAGE-signals-death-through-JNK 48 9.80e-01 9.85e-01 0.01750 -0.009800 1.45e-02 9.07e-01 8.62e-01
DAP12-interactions 20 9.92e-01 9.94e-01 0.01700 0.007490 -1.53e-02 9.54e-01 9.06e-01
DNA-Damage-Bypass 40 9.84e-01 9.86e-01 0.01600 -0.015600 -3.38e-03 8.64e-01 9.70e-01
Cell-Cycle 452 8.66e-01 9.17e-01 0.01460 -0.001620 -1.45e-02 9.53e-01 6.00e-01
Cell-Cycle,-Mitotic 384 9.60e-01 9.72e-01 0.00815 -0.005760 -5.77e-03 8.48e-01 8.47e-01
Signaling-by-ERBB4 41 9.99e-01 9.99e-01 0.00417 0.002390 3.42e-03 9.79e-01 9.70e-01
Negative-regulators-of-DDX58/IFIH1-signaling 31 9.99e-01 9.99e-01 0.00385 -0.001220 3.65e-03 9.91e-01 9.72e-01



Detailed Gene set reports


PI-3K-cascade:FGFR2

metric value
setSize 10
pMANOVA 0.00114
p.adjustMANOVA 0.0105
s.dist 0.696
s.ab -0.284
s.d36 0.635
p.ab 0.119
p.d36 0.00051




Gene ab d36
Fgf1 -3926.5 5665
Fgf16 -4034.5 5094
Fgf9 -5772.5 3111
Gab1 -3225.5 4420
Pik3r1 -2910.5 4811
Frs2 -4622.5 229
Pik3ca -75.5 473

Click HERE to show all gene set members

ab d36
Fgf1 -3926.5 5665
Fgf16 -4034.5 5094
Fgf2 165.5 5279
Fgf9 -5772.5 3111
Frs2 -4622.5 229
Gab1 -3225.5 4420
Grb2 4354.5 5789
Pik3ca -75.5 473
Pik3r1 -2910.5 4811
Ptpn11 1827.5 1935





PI-3K-cascade:FGFR4

metric value
setSize 10
pMANOVA 0.00114
p.adjustMANOVA 0.0105
s.dist 0.696
s.ab -0.284
s.d36 0.635
p.ab 0.119
p.d36 0.00051




Gene ab d36
Fgf1 -3926.5 5665
Fgf16 -4034.5 5094
Fgf9 -5772.5 3111
Gab1 -3225.5 4420
Pik3r1 -2910.5 4811
Frs2 -4622.5 229
Pik3ca -75.5 473

Click HERE to show all gene set members

ab d36
Fgf1 -3926.5 5665
Fgf16 -4034.5 5094
Fgf2 165.5 5279
Fgf9 -5772.5 3111
Frs2 -4622.5 229
Gab1 -3225.5 4420
Grb2 4354.5 5789
Pik3ca -75.5 473
Pik3r1 -2910.5 4811
Ptpn11 1827.5 1935





Regulation-of-pyruvate-dehydrogenase-(PDH)-complex

metric value
setSize 15
pMANOVA 4.78e-05
p.adjustMANOVA 0.000951
s.dist 0.677
s.ab -0.158
s.d36 0.659
p.ab 0.288
p.d36 1e-05




Gene ab d36
Rxra -5660.5 4852
Pdk2 -4667.5 5542
Pdp1 -3944.5 5660
Ppard -3952.5 3976
Pdk4 -2607.5 5541
Pdp2 -2320.5 5623
Dlat -1788.5 3921
Pdha1 -1301.5 4866
Pdpr -1393.5 3743
Pdk1 -838.5 4653
Dld -74.5 4418
Pdhb -242.5 1105

Click HERE to show all gene set members

ab d36
Dlat -1788.5 3921
Dld -74.5 4418
Gstz1 4779.5 2839
Pdha1 -1301.5 4866
Pdhb -242.5 1105
Pdhx 2159.5 1148
Pdk1 -838.5 4653
Pdk2 -4667.5 5542
Pdk3 5741.5 -572
Pdk4 -2607.5 5541
Pdp1 -3944.5 5660
Pdp2 -2320.5 5623
Pdpr -1393.5 3743
Ppard -3952.5 3976
Rxra -5660.5 4852





Biotin-transport-and-metabolism

metric value
setSize 11
pMANOVA 0.000932
p.adjustMANOVA 0.00926
s.dist 0.652
s.ab -0.0437
s.d36 0.65
p.ab 0.802
p.d36 0.000189




Gene ab d36
Acacb -5412.5 5448
Hlcs -4418.5 5724
Pcca -2030.5 4215
Slc5a6 -2743.5 2729
Mccc1 -1202.5 5073

Click HERE to show all gene set members

ab d36
Acaca 5335.5 -48
Acacb -5412.5 5448
Btd -540.5 -217
Hlcs -4418.5 5724
Mccc1 -1202.5 5073
Mccc2 123.5 4709
Pcca -2030.5 4215
Pccb 1469.5 4972
Pcx 2427.5 5152
Pdzd11 2657.5 3735
Slc5a6 -2743.5 2729





Peptide-chain-elongation

metric value
setSize 69
pMANOVA 2.23e-18
p.adjustMANOVA 7.36e-16
s.dist 0.625
s.ab 0.004
s.d36 -0.625
p.ab 0.954
p.d36 2.79e-19




Gene ab d36
Eef1a1 5423.5 -5451
Rps23 5402.5 -5063
Rps20 5084.5 -5300
Rps4x 5645.5 -4580
Rpl3 4229.5 -5770
Rpl22 4995.5 -4324
Rpl26 4899.5 -4289
Rpl23 5208.5 -4021
Rps3a1 4558.5 -4165
Rpl22l1 3523.5 -5282
Rpl4 5629.5 -3114
Rps6 5412.5 -3069
Rps24 4956.5 -3149
Rpl14 4942.5 -2991
Rps8 4049.5 -3452
Rps25 4129.5 -3204
Rpl38 3088.5 -4166
Rps7 2833.5 -3831
Rpl27-ps3 5035.5 -2001
Rps27l 3129.5 -3066

Click HERE to show all gene set members

ab d36
Eef1a1 5423.5 -5451
Eef2 -5737.5 3284
Flt3l 2020.5 -3039
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Uba52 -2952.5 -3903





Branched-chain-amino-acid-catabolism

metric value
setSize 20
pMANOVA 1.11e-05
p.adjustMANOVA 0.000279
s.dist 0.614
s.ab 0.000211
s.d36 0.614
p.ab 0.999
p.d36 2e-06




Gene ab d36
Slc25a44 4916.5 5022
Ppm1k 1699.5 5569
Hibadh 1994.5 4602
Aldh6a1 2168.5 4053
Acad8 2518.5 3269
Dbt 1437.5 4527
Ivd 1340.5 4608
Acadsb 209.5 4734
Mccc2 123.5 4709
Echs1 164.5 3118

Click HERE to show all gene set members

ab d36
Acad8 2518.5 3269
Acadsb 209.5 4734
Acat1 -686.5 5401
Aldh6a1 2168.5 4053
Auh -3103.5 -110
Bcat2 -584.5 3147
Bckdha -3922.5 1893
Bckdhb -3245.5 3419
Bckdk -2514.5 3033
Dbt 1437.5 4527
Dld -74.5 4418
Echs1 164.5 3118
Hibadh 1994.5 4602
Hibch -1215.5 1775
Hsd17b10 -2698.5 -1173
Ivd 1340.5 4608
Mccc1 -1202.5 5073
Mccc2 123.5 4709
Ppm1k 1699.5 5569
Slc25a44 4916.5 5022





Citric-acid-cycle-(TCA-cycle)

metric value
setSize 22
pMANOVA 1.42e-05
p.adjustMANOVA 0.00035
s.dist 0.608
s.ab -0.35
s.d36 0.498
p.ab 0.00452
p.d36 5.33e-05




Gene ab d36
Me3 -4723.5 5377
Nnt -4133.5 5267
Sdha -3660.5 5084
Cs -3641.5 5068
Ogdh -4534.5 3453
Sdhc -3310.5 4190
Aco2 -1999.5 5196
Idh3g -3160.5 3102
Idh3b -3365.5 2855
Fh1 -2493.5 3821
Idh3a -1539.5 5451
Suclg2 -1506.5 4383
Mdh2 -2195.5 2604
Dlst -1191.5 4406
Fahd1 -3322.5 751
Sdhd -715.5 2641
Suclg1 -2218.5 231
Dld -74.5 4418
Sucla2 -6.5 4032

Click HERE to show all gene set members

ab d36
Aco2 -1999.5 5196
Cs -3641.5 5068
Dld -74.5 4418
Dlst -1191.5 4406
Fahd1 -3322.5 751
Fh1 -2493.5 3821
Idh2 -2044.5 -2081
Idh3a -1539.5 5451
Idh3b -3365.5 2855
Idh3g -3160.5 3102
Mdh2 -2195.5 2604
Me2 3078.5 -5586
Me3 -4723.5 5377
Nnt -4133.5 5267
Ogdh -4534.5 3453
Sdha -3660.5 5084
Sdhb -1815.5 -1632
Sdhc -3310.5 4190
Sdhd -715.5 2641
Sucla2 -6.5 4032
Suclg1 -2218.5 231
Suclg2 -1506.5 4383





Carnitine-metabolism

metric value
setSize 12
pMANOVA 0.00124
p.adjustMANOVA 0.011
s.dist 0.603
s.ab 0.0429
s.d36 0.601
p.ab 0.797
p.d36 0.000312




Gene ab d36
Cpt1a 5087.5 3863
Prkaa2 3048.5 4407
Slc22a5 2824.5 1183

Click HERE to show all gene set members

ab d36
Cpt1a 5087.5 3863
Cpt1b -1527.5 4597
Cpt2 -2215.5 5836
Mid1ip1 -5502.5 5735
Ppard -3952.5 3976
Prkaa2 3048.5 4407
Prkab2 -1248.5 3948
Prkag2 5723.5 -299
Rxra -5660.5 4852
Slc22a5 2824.5 1183
Slc25a20 -233.5 5561
Thrsp 5092.5 -1897





Viral-mRNA-Translation

metric value
setSize 69
pMANOVA 3.98e-17
p.adjustMANOVA 6.45e-15
s.dist 0.602
s.ab -0.0011
s.d36 -0.602
p.ab 0.987
p.d36 5.35e-18




Gene ab d36
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419
Rpl29 -3224.5 -3135
Rpl12 -3318.5 -2902

Click HERE to show all gene set members

ab d36
Dnajc3 -1675.5 3671
Flt3l 2020.5 -3039
Grsf1 -714.5 3514
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Uba52 -2952.5 -3903





Eukaryotic-Translation-Elongation

metric value
setSize 73
pMANOVA 1.21e-17
p.adjustMANOVA 2.99e-15
s.dist 0.595
s.ab 0.00569
s.d36 -0.595
p.ab 0.933
p.d36 1.49e-18




Gene ab d36
Eef1a1 5423.5 -5451
Rps23 5402.5 -5063
Rps20 5084.5 -5300
Rps4x 5645.5 -4580
Rpl3 4229.5 -5770
Rpl22 4995.5 -4324
Rpl26 4899.5 -4289
Rpl23 5208.5 -4021
Rps3a1 4558.5 -4165
Rpl22l1 3523.5 -5282
Rpl4 5629.5 -3114
Rps6 5412.5 -3069
Rps24 4956.5 -3149
Rpl14 4942.5 -2991
Rps8 4049.5 -3452
Rps25 4129.5 -3204
Rpl38 3088.5 -4166
Rps7 2833.5 -3831
Eef1b2 4624.5 -2338
Rpl27-ps3 5035.5 -2001

Click HERE to show all gene set members

ab d36
Eef1a1 5423.5 -5451
Eef1a2 -5103.5 5587
Eef1b2 4624.5 -2338
Eef1d -2694.5 -3096
Eef1g 3456.5 -2304
Eef2 -5737.5 3284
Flt3l 2020.5 -3039
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Uba52 -2952.5 -3903





Eukaryotic-Translation-Termination

metric value
setSize 72
pMANOVA 3.35e-17
p.adjustMANOVA 6.45e-15
s.dist 0.588
s.ab -0.0215
s.d36 -0.588
p.ab 0.753
p.d36 6.16e-18




Gene ab d36
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Trmt112 -3936.5 -3298
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419
Rpl29 -3224.5 -3135

Click HERE to show all gene set members

ab d36
Apeh -5235.5 461
Etf1 -2724.5 2042
Flt3l 2020.5 -3039
Gspt1 -3382.5 2577
N6amt1 3799.5 375
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Trmt112 -3936.5 -3298
Uba52 -2952.5 -3903





Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency

metric value
setSize 80
pMANOVA 1.58e-18
p.adjustMANOVA 7.36e-16
s.dist 0.587
s.ab 0.0457
s.d36 -0.585
p.ab 0.481
p.d36 1.4e-19




Gene ab d36
Rps23 5402.5 -5063
Rps20 5084.5 -5300
Rps4x 5645.5 -4580
Rpl3 4229.5 -5770
Atf3 4189.5 -5786
Ddit3 4493.5 -5098
Rpl22 4995.5 -4324
Rpl26 4899.5 -4289
Rpl23 5208.5 -4021
Rps3a1 4558.5 -4165
Rpl22l1 3523.5 -5282
Rpl4 5629.5 -3114
Rps6 5412.5 -3069
Rps24 4956.5 -3149
Rpl14 4942.5 -2991
Rps8 4049.5 -3452
Asns 5277.5 -2511
Rps25 4129.5 -3204
Rpl38 3088.5 -4166
Rps7 2833.5 -3831

Click HERE to show all gene set members

ab d36
Asns 5277.5 -2511
Atf2 4155.5 2027
Atf3 4189.5 -5786
Atf4 1220.5 -4828
Cebpb -4061.5 1643
Cebpg 2577.5 -2114
Ddit3 4493.5 -5098
Eif2ak4 2060.5 -3104
Eif2s1 290.5 1361
Eif2s2 -3841.5 -2841
Eif2s3x -778.5 3655
Flt3l 2020.5 -3039
Impact 1551.5 -5220
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Trib3 987.5 -1981
Uba52 -2952.5 -3903





Selenocysteine-synthesis

metric value
setSize 73
pMANOVA 4.18e-17
p.adjustMANOVA 6.45e-15
s.dist 0.584
s.ab -0.00957
s.d36 -0.584
p.ab 0.888
p.d36 6.35e-18




Gene ab d36
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419
Rpl29 -3224.5 -3135
Rpl12 -3318.5 -2902

Click HERE to show all gene set members

ab d36
Eefsec -894.5 -2973
Flt3l 2020.5 -3039
Pstk -4403.5 5239
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Sars -5060.5 575
Secisbp2 -4620.5 857
Sephs2 4892.5 -4752
Sepsecs 3483.5 1508
Uba52 -2952.5 -3903





Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)

metric value
setSize 73
pMANOVA 2.35e-16
p.adjustMANOVA 3.22e-14
s.dist 0.57
s.ab -0.0186
s.d36 -0.569
p.ab 0.783
p.d36 4.12e-17




Gene ab d36
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419
Rpl29 -3224.5 -3135
Rpl12 -3318.5 -2902

Click HERE to show all gene set members

ab d36
Eif4g1 -2207.5 3277
Etf1 -2724.5 2042
Flt3l 2020.5 -3039
Gspt1 -3382.5 2577
Ncbp1 -1856.5 -2759
Ncbp2 335.5 -250
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Uba52 -2952.5 -3903
Upf1 -675.5 1867





Physiological-factors

metric value
setSize 11
pMANOVA 0.00273
p.adjustMANOVA 0.0201
s.dist 0.569
s.ab 0.327
s.d36 0.466
p.ab 0.0603
p.d36 0.00749




Gene ab d36
Nppa 5691.5 5709
Corin 4788.5 3911
Tbx5 5394.5 1823
Wwtr1 4507.5 1208
Npr2 2678.5 1726
Hipk2 1007.5 3765
Hipk1 33.5 1662

Click HERE to show all gene set members

ab d36
Corin 4788.5 3911
Gata4 -5268.5 4151
Hipk1 33.5 1662
Hipk2 1007.5 3765
Kat2b -304.5 4890
Nkx2-5 -3190.5 4590
Nppa 5691.5 5709
Npr1 4525.5 -3976
Npr2 2678.5 1726
Tbx5 5394.5 1823
Wwtr1 4507.5 1208





Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle

metric value
setSize 50
pMANOVA 2.52e-10
p.adjustMANOVA 1.15e-08
s.dist 0.567
s.ab -0.305
s.d36 0.478
p.ab 0.00019
p.d36 5.06e-09




Gene ab d36
Rxra -5660.5 4852
Pdk2 -4667.5 5542
Me3 -4723.5 5377
Me1 -4151.5 5434
Pdp1 -3944.5 5660
Nnt -4133.5 5267
D2hgdh -3542.5 5573
Sdha -3660.5 5084
Cs -3641.5 5068
L2hgdh -3319.5 5266
Vdac1 -3120.5 5253
Ppard -3952.5 3976
Ogdh -4534.5 3453
Pdk4 -2607.5 5541
Sdhc -3310.5 4190
Pdp2 -2320.5 5623
Aco2 -1999.5 5196
Idh3g -3160.5 3102
Idh3b -3365.5 2855
Fh1 -2493.5 3821

Click HERE to show all gene set members

ab d36
Aco2 -1999.5 5196
Adhfe1 -258.5 5579
Bsg -3352.5 403
Cs -3641.5 5068
D2hgdh -3542.5 5573
Dlat -1788.5 3921
Dld -74.5 4418
Dlst -1191.5 4406
Fahd1 -3322.5 751
Fh1 -2493.5 3821
Glo1 538.5 2947
Gstz1 4779.5 2839
Hagh -3951.5 -2989
Idh2 -2044.5 -2081
Idh3a -1539.5 5451
Idh3b -3365.5 2855
Idh3g -3160.5 3102
L2hgdh -3319.5 5266
Ldha -4261.5 -1535
Ldhb -1477.5 532
Mdh2 -2195.5 2604
Me1 -4151.5 5434
Me2 3078.5 -5586
Me3 -4723.5 5377
Mpc1 -2394.5 440
Mpc2 -2713.5 -1034
Nnt -4133.5 5267
Ogdh -4534.5 3453
Pdha1 -1301.5 4866
Pdhb -242.5 1105
Pdhx 2159.5 1148
Pdk1 -838.5 4653
Pdk2 -4667.5 5542
Pdk3 5741.5 -572
Pdk4 -2607.5 5541
Pdp1 -3944.5 5660
Pdp2 -2320.5 5623
Pdpr -1393.5 3743
Ppard -3952.5 3976
Rxra -5660.5 4852
Sdha -3660.5 5084
Sdhb -1815.5 -1632
Sdhc -3310.5 4190
Sdhd -715.5 2641
Slc16a1 -3831.5 892
Slc16a3 3452.5 -5626
Sucla2 -6.5 4032
Suclg1 -2218.5 231
Suclg2 -1506.5 4383
Vdac1 -3120.5 5253





PI-3K-cascade:FGFR3

metric value
setSize 11
pMANOVA 0.00802
p.adjustMANOVA 0.0471
s.dist 0.562
s.ab -0.265
s.d36 0.496
p.ab 0.128
p.d36 0.00442




Gene ab d36
Fgf1 -3926.5 5665
Fgf16 -4034.5 5094
Fgf9 -5772.5 3111
Gab1 -3225.5 4420
Pik3r1 -2910.5 4811
Frs2 -4622.5 229
Pik3ca -75.5 473

Click HERE to show all gene set members

ab d36
Fgf1 -3926.5 5665
Fgf16 -4034.5 5094
Fgf2 165.5 5279
Fgf9 -5772.5 3111
Fgfr3 -572.5 -5392
Frs2 -4622.5 229
Gab1 -3225.5 4420
Grb2 4354.5 5789
Pik3ca -75.5 473
Pik3r1 -2910.5 4811
Ptpn11 1827.5 1935





Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants

metric value
setSize 14
pMANOVA 0.000728
p.adjustMANOVA 0.00788
s.dist 0.557
s.ab -0.379
s.d36 -0.408
p.ab 0.0141
p.d36 0.00827




Gene ab d36
Jag2 -5622.5 -4343
Jag1 -3442.5 -5169
Rps27a -4190.5 -4207
Neurl1a -4386.5 -3781
Dll4 -2189.5 -6016
Mib2 -4715.5 -2662
Uba52 -2952.5 -3903
Ubb -2267.5 -1407
Adam10 -596.5 -1314

Click HERE to show all gene set members

ab d36
Adam10 -596.5 -1314
Adam17 -5932.5 940
Dll1 -5422.5 1293
Dll4 -2189.5 -6016
Jag1 -3442.5 -5169
Jag2 -5622.5 -4343
Mib1 5391.5 4576
Mib2 -4715.5 -2662
Neurl1a -4386.5 -3781
Neurl1b 68.5 -5045
Notch1 2890.5 -3995
Rps27a -4190.5 -4207
Uba52 -2952.5 -3903
Ubb -2267.5 -1407





Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer

metric value
setSize 14
pMANOVA 0.000728
p.adjustMANOVA 0.00788
s.dist 0.557
s.ab -0.379
s.d36 -0.408
p.ab 0.0141
p.d36 0.00827




Gene ab d36
Jag2 -5622.5 -4343
Jag1 -3442.5 -5169
Rps27a -4190.5 -4207
Neurl1a -4386.5 -3781
Dll4 -2189.5 -6016
Mib2 -4715.5 -2662
Uba52 -2952.5 -3903
Ubb -2267.5 -1407
Adam10 -596.5 -1314

Click HERE to show all gene set members

ab d36
Adam10 -596.5 -1314
Adam17 -5932.5 940
Dll1 -5422.5 1293
Dll4 -2189.5 -6016
Jag1 -3442.5 -5169
Jag2 -5622.5 -4343
Mib1 5391.5 4576
Mib2 -4715.5 -2662
Neurl1a -4386.5 -3781
Neurl1b 68.5 -5045
Notch1 2890.5 -3995
Rps27a -4190.5 -4207
Uba52 -2952.5 -3903
Ubb -2267.5 -1407





PI-3K-cascade:FGFR1

metric value
setSize 10
pMANOVA 0.0141
p.adjustMANOVA 0.0721
s.dist 0.547
s.ab -0.168
s.d36 0.52
p.ab 0.356
p.d36 0.00441




Gene ab d36
Fgf1 -3926.5 5665
Fgf9 -5772.5 3111
Gab1 -3225.5 4420
Pik3r1 -2910.5 4811
Frs2 -4622.5 229
Pik3ca -75.5 473

Click HERE to show all gene set members

ab d36
Fgf1 -3926.5 5665
Fgf2 165.5 5279
Fgf9 -5772.5 3111
Fgfr1 2843.5 -1711
Frs2 -4622.5 229
Gab1 -3225.5 4420
Grb2 4354.5 5789
Pik3ca -75.5 473
Pik3r1 -2910.5 4811
Ptpn11 1827.5 1935





Prolactin-receptor-signaling

metric value
setSize 10
pMANOVA 0.0102
p.adjustMANOVA 0.0565
s.dist 0.532
s.ab 0.206
s.d36 0.49
p.ab 0.258
p.d36 0.00729




Gene ab d36
Cul1 3128.5 5019
Skp1a 3485.5 3561
Jak2 3917.5 2392
Stat5b 2646.5 2564
Ptpn11 1827.5 1935
Ghr 877.5 3666

Click HERE to show all gene set members

ab d36
Btrc -2260.5 5798
Cul1 3128.5 5019
Ghr 877.5 3666
Jak2 3917.5 2392
Ptpn11 1827.5 1935
Rbx1 1071.5 -3541
Sh2b1 -923.5 1127
Skp1a 3485.5 3561
Stat5a -2873.5 5707
Stat5b 2646.5 2564





eNOS-activation

metric value
setSize 11
pMANOVA 0.0099
p.adjustMANOVA 0.0553
s.dist 0.527
s.ab 0.00508
s.d36 -0.527
p.ab 0.977
p.d36 0.00248




Gene ab d36
Cav1 4754.5 -5886
Nos3 3513.5 -5802
Zdhhc21 1540.5 -5484
Calm1 1392.5 -5536
Spr 602.5 -3175

Click HERE to show all gene set members

ab d36
Akt1 -4927.5 -1552
Calm1 1392.5 -5536
Cav1 4754.5 -5886
Cygb -2389.5 -4825
Ddah1 -4911.5 1178
Ddah2 -24.5 -2037
Hsp90aa1 -668.5 -4565
Lypla1 -35.5 2373
Nos3 3513.5 -5802
Spr 602.5 -3175
Zdhhc21 1540.5 -5484





CS/DS-degradation

metric value
setSize 10
pMANOVA 0.025
p.adjustMANOVA 0.108
s.dist 0.52
s.ab 0.338
s.d36 -0.395
p.ab 0.0643
p.d36 0.0306




Gene ab d36
Bgn 3222.5 -5250
Arsb 4253.5 -3367
Hyal1 5068.5 -2362
Cspg4 2597.5 -4531
Hexb 4240.5 -2476
Dcn 1015.5 -4121

Click HERE to show all gene set members

ab d36
Arsb 4253.5 -3367
Bgn 3222.5 -5250
Cspg4 2597.5 -4531
Dcn 1015.5 -4121
Hexa -1661.5 -5388
Hexb 4240.5 -2476
Hyal1 5068.5 -2362
Ids 884.5 1870
Idua -2544.5 996
Vcan 1621.5 352





Formation-of-a-pool-of-free-40S-subunits

metric value
setSize 81
pMANOVA 4.27e-15
p.adjustMANOVA 4.79e-13
s.dist 0.516
s.ab -0.0445
s.d36 -0.514
p.ab 0.489
p.d36 1.29e-15




Gene ab d36
Eif3d -5990.5 -4761
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Eif3k -4571.5 -3934
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419

Click HERE to show all gene set members

ab d36
Eif1ax 1482.5 4994
Eif3a -2077.5 3749
Eif3b -4137.5 3505
Eif3c -4989.5 2476
Eif3d -5990.5 -4761
Eif3e 4518.5 -631
Eif3f 894.5 -1883
Eif3g -3783.5 -1654
Eif3h -453.5 1501
Eif3i 256.5 -2586
Eif3j2 -5246.5 3758
Eif3k -4571.5 -3934
Eif3l -3034.5 1013
Eif3m 2305.5 208
Flt3l 2020.5 -3039
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Uba52 -2952.5 -3903





Voltage-gated-Potassium-channels

metric value
setSize 13
pMANOVA 0.00756
p.adjustMANOVA 0.0453
s.dist 0.516
s.ab -0.185
s.d36 0.481
p.ab 0.248
p.d36 0.00265




Gene ab d36
Kcnb1 -5019.5 5736
Kcng2 -5044.5 4262
Kcnv2 -3918.5 4393
Kcnd2 -1801.5 5545
Kcna7 -1218.5 3160
Kcnd3 -381.5 4361

Click HERE to show all gene set members

ab d36
Kcna2 1184.5 377
Kcna5 -4254.5 -1467
Kcna6 -1161.5 -1157
Kcna7 -1218.5 3160
Kcnb1 -5019.5 5736
Kcnc3 3193.5 4194
Kcnd2 -1801.5 5545
Kcnd3 -381.5 4361
Kcng2 -5044.5 4262
Kcnh2 5013.5 4284
Kcnq1 824.5 4876
Kcnq4 -3437.5 -2543
Kcnv2 -3918.5 4393





SRP-dependent-cotranslational-protein-targeting-to-membrane

metric value
setSize 92
pMANOVA 4.84e-16
p.adjustMANOVA 5.97e-14
s.dist 0.509
s.ab 0.043
s.d36 -0.507
p.ab 0.477
p.d36 4.57e-17




Gene ab d36
Rps23 5402.5 -5063
Rps20 5084.5 -5300
Rps4x 5645.5 -4580
Spcs2 4681.5 -5523
Rpl3 4229.5 -5770
Sec61b 4402.5 -5302
Tram1 4203.5 -5435
Rpl22 4995.5 -4324
Rpl26 4899.5 -4289
Rpl23 5208.5 -4021
Rpn2 4616.5 -4517
Rps3a1 4558.5 -4165
Rpl22l1 3523.5 -5282
Rpl4 5629.5 -3114
Rps6 5412.5 -3069
Rps24 4956.5 -3149
Rpl14 4942.5 -2991
Rps8 4049.5 -3452
Rps25 4129.5 -3204
Ssr1 4511.5 -2905

Click HERE to show all gene set members

ab d36
Ddost 2379.5 116
Flt3l 2020.5 -3039
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rpn1 -1826.5 -4195
Rpn2 4616.5 -4517
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Sec11a -4419.5 -1021
Sec11c 837.5 -5159
Sec61a1 1251.5 -619
Sec61a2 -2542.5 -1400
Sec61b 4402.5 -5302
Sec61g -4711.5 -2153
Spcs1 4081.5 -2025
Spcs2 4681.5 -5523
Spcs3 -790.5 5570
Srp14 4462.5 -2858
Srp19 -2399.5 194
Srp54a -1674.5 4489
Srp68 -3617.5 4648
Srp72 -2379.5 4447
Srp9 3704.5 232
Srpr -5627.5 5043
Srprb 80.5 -128
Ssr1 4511.5 -2905
Ssr2 2079.5 -5247
Ssr3 3890.5 3297
Ssr4 3039.5 -3852
Tram1 4203.5 -5435
Uba52 -2952.5 -3903





G-beta:gamma-signalling-through-BTK

metric value
setSize 11
pMANOVA 0.021
p.adjustMANOVA 0.0963
s.dist 0.508
s.ab 0.371
s.d36 -0.346
p.ab 0.0331
p.d36 0.0468




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034

Click HERE to show all gene set members

ab d36
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034





Activation-of-G-protein-gated-Potassium-channels

metric value
setSize 16
pMANOVA 0.00291
p.adjustMANOVA 0.021
s.dist 0.501
s.ab 0.491
s.d36 -0.1
p.ab 0.000676
p.d36 0.488




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gabbr1 5384.5 -3897
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034

Click HERE to show all gene set members

ab d36
Gabbr1 5384.5 -3897
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034
Kcnj12 2820.5 4777
Kcnj2 2369.5 5757
Kcnj3 5610.5 1320
Kcnj5 5491.5 4706





G-protein-gated-Potassium-channels

metric value
setSize 16
pMANOVA 0.00291
p.adjustMANOVA 0.021
s.dist 0.501
s.ab 0.491
s.d36 -0.1
p.ab 0.000676
p.d36 0.488




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gabbr1 5384.5 -3897
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034

Click HERE to show all gene set members

ab d36
Gabbr1 5384.5 -3897
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034
Kcnj12 2820.5 4777
Kcnj2 2369.5 5757
Kcnj3 5610.5 1320
Kcnj5 5491.5 4706





Inhibition--of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits

metric value
setSize 16
pMANOVA 0.00291
p.adjustMANOVA 0.021
s.dist 0.501
s.ab 0.491
s.d36 -0.1
p.ab 0.000676
p.d36 0.488




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gabbr1 5384.5 -3897
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034

Click HERE to show all gene set members

ab d36
Gabbr1 5384.5 -3897
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034
Kcnj12 2820.5 4777
Kcnj2 2369.5 5757
Kcnj3 5610.5 1320
Kcnj5 5491.5 4706





Acyl-chain-remodelling-of-PE

metric value
setSize 13
pMANOVA 0.00441
p.adjustMANOVA 0.0304
s.dist 0.501
s.ab 0.378
s.d36 0.328
p.ab 0.0182
p.d36 0.0407




Gene ab d36
Abhd4 5737.5 4289
Mboat2 5506.5 3712
Pnpla8 4906.5 4097
Pla2g4a 5119.5 1798
Pla2g4e 5800.5 1442
Pla2g12a 1398.5 2446

Click HERE to show all gene set members

ab d36
Abhd4 5737.5 4289
Lpcat3 -1378.5 5291
Lpcat4 1840.5 -4535
Mboat2 5506.5 3712
Pla2g12a 1398.5 2446
Pla2g4a 5119.5 1798
Pla2g4b 5743.5 -4162
Pla2g4e 5800.5 1442
Pla2g5 -1581.5 5797
Pla2g6 -4934.5 1748
Pla2r1 5094.5 -3462
Plbd1 -5828.5 5720
Pnpla8 4906.5 4097





G-protein-activation

metric value
setSize 15
pMANOVA 0.00714
p.adjustMANOVA 0.043
s.dist 0.489
s.ab 0.414
s.d36 -0.26
p.ab 0.00549
p.d36 0.0813




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034
Gnai3 4769.5 -6

Click HERE to show all gene set members

ab d36
Gnai1 4876.5 1477
Gnai2 -2023.5 -2736
Gnai3 4769.5 -6
Gnao1 4461.5 391
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034





Pyruvate-metabolism

metric value
setSize 26
pMANOVA 0.000223
p.adjustMANOVA 0.00302
s.dist 0.484
s.ab -0.246
s.d36 0.417
p.ab 0.0301
p.d36 0.000234




Gene ab d36
Rxra -5660.5 4852
Pdk2 -4667.5 5542
Me1 -4151.5 5434
Pdp1 -3944.5 5660
Vdac1 -3120.5 5253
Ppard -3952.5 3976
Pdk4 -2607.5 5541
Pdp2 -2320.5 5623
Dlat -1788.5 3921
Pdha1 -1301.5 4866
Pdpr -1393.5 3743
Pdk1 -838.5 4653
Slc16a1 -3831.5 892
Bsg -3352.5 403
Mpc1 -2394.5 440
Ldhb -1477.5 532
Dld -74.5 4418
Pdhb -242.5 1105

Click HERE to show all gene set members

ab d36
Bsg -3352.5 403
Dlat -1788.5 3921
Dld -74.5 4418
Glo1 538.5 2947
Gstz1 4779.5 2839
Hagh -3951.5 -2989
Ldha -4261.5 -1535
Ldhb -1477.5 532
Me1 -4151.5 5434
Mpc1 -2394.5 440
Mpc2 -2713.5 -1034
Pdha1 -1301.5 4866
Pdhb -242.5 1105
Pdhx 2159.5 1148
Pdk1 -838.5 4653
Pdk2 -4667.5 5542
Pdk3 5741.5 -572
Pdk4 -2607.5 5541
Pdp1 -3944.5 5660
Pdp2 -2320.5 5623
Pdpr -1393.5 3743
Ppard -3952.5 3976
Rxra -5660.5 4852
Slc16a1 -3831.5 892
Slc16a3 3452.5 -5626
Vdac1 -3120.5 5253





Collagen-chain-trimerization

metric value
setSize 25
pMANOVA 9.17e-05
p.adjustMANOVA 0.00157
s.dist 0.483
s.ab -0.135
s.d36 -0.464
p.ab 0.244
p.d36 5.97e-05




Gene ab d36
Col20a1 -4825.5 -5211
Col4a1 -4700.5 -4897
Col6a6 -5765.5 -3954
Col4a2 -5585.5 -3480
Col11a2 -4820.5 -3718
Col6a3 -5704.5 -2843
Col27a1 -4292.5 -3531
Col15a1 -3240.5 -4013
Col6a2 -2323.5 -5510
Col6a1 -2301.5 -5407
Col5a3 -2642.5 -3213
Col16a1 -952.5 -5719
Col5a1 -1031.5 -4402
Col8a1 -4520.5 -564
Col3a1 -1219.5 -1922
Col1a1 -571.5 -1205

Click HERE to show all gene set members

ab d36
Col11a2 -4820.5 -3718
Col14a1 3297.5 1153
Col15a1 -3240.5 -4013
Col16a1 -952.5 -5719
Col18a1 5581.5 -4573
Col1a1 -571.5 -1205
Col1a2 585.5 -2063
Col20a1 -4825.5 -5211
Col23a1 5731.5 2306
Col27a1 -4292.5 -3531
Col3a1 -1219.5 -1922
Col4a1 -4700.5 -4897
Col4a2 -5585.5 -3480
Col4a3 583.5 -4381
Col4a4 4684.5 -4085
Col4a5 3292.5 2171
Col4a6 5622.5 92
Col5a1 -1031.5 -4402
Col5a2 1784.5 -1848
Col5a3 -2642.5 -3213
Col6a1 -2301.5 -5407
Col6a2 -2323.5 -5510
Col6a3 -5704.5 -2843
Col6a6 -5765.5 -3954
Col8a1 -4520.5 -564





ADP-signalling-through-P2Y-purinoceptor-12

metric value
setSize 14
pMANOVA 0.0118
p.adjustMANOVA 0.0634
s.dist 0.481
s.ab 0.388
s.d36 -0.284
p.ab 0.0119
p.d36 0.0655




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034
Gnai3 4769.5 -6

Click HERE to show all gene set members

ab d36
Gnai1 4876.5 1477
Gnai2 -2023.5 -2736
Gnai3 4769.5 -6
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034





Thrombin-signalling-through-proteinase-activated-receptors-(PARs)

metric value
setSize 21
pMANOVA 0.00137
p.adjustMANOVA 0.0116
s.dist 0.48
s.ab 0.336
s.d36 -0.343
p.ab 0.00764
p.d36 0.00656




Gene ab d36
Gng2 5782.5 -5206
F2r 5371.5 -5362
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Arrb1 3464.5 -5200
Src 5217.5 -2972
Gngt2 5414.5 -2034
Arrb2 1118.5 -3266
Mapk3 435.5 -5175
Gnaq 425.5 -2832
Gna13 47.5 -635

Click HERE to show all gene set members

ab d36
Arrb1 3464.5 -5200
Arrb2 1118.5 -3266
F2r 5371.5 -5362
Gna11 -3119.5 -3588
Gna12 970.5 4107
Gna13 47.5 -635
Gnaq 425.5 -2832
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034
Mapk1 2361.5 4015
Mapk3 435.5 -5175
Src 5217.5 -2972





Interleukin-7-signaling

metric value
setSize 15
pMANOVA 0.00926
p.adjustMANOVA 0.0527
s.dist 0.478
s.ab -0.375
s.d36 0.296
p.ab 0.0119
p.d36 0.0473




Gene ab d36
Jak1 -5522.5 3290
Smarca4 -4251.5 4134
Irs1 -6067.5 2770
Stat5a -2873.5 5707
Pik3r1 -2910.5 4811
Cish -6028.5 2049
Irs2 -6024.5 528
Brwd1 -2526.5 1177
Pik3r3 -407.5 5080
Pik3r2 -347.5 2632

Click HERE to show all gene set members

ab d36
Brwd1 -2526.5 1177
Cish -6028.5 2049
Crlf2 480.5 -5715
Irs1 -6067.5 2770
Irs2 -6024.5 528
Jak1 -5522.5 3290
Jak3 -4806.5 -2877
Pik3r1 -2910.5 4811
Pik3r2 -347.5 2632
Pik3r3 -407.5 5080
Smarca4 -4251.5 4134
Socs2 -121.5 -3402
Stat3 3357.5 2307
Stat5a -2873.5 5707
Stat5b 2646.5 2564





Selenoamino-acid-metabolism

metric value
setSize 90
pMANOVA 2.44e-14
p.adjustMANOVA 2.51e-12
s.dist 0.478
s.ab -0.0307
s.d36 -0.477
p.ab 0.616
p.d36 5.65e-15




Gene ab d36
Aimp2 -5750.5 -5216
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419
Rpl29 -3224.5 -3135

Click HERE to show all gene set members

ab d36
Ahcy -1307.5 -1303
Aimp1 1129.5 -3521
Aimp2 -5750.5 -5216
Dars -4369.5 1335
Eefsec -894.5 -2973
Eprs -2478.5 -837
Flt3l 2020.5 -3039
Gsr 55.5 2035
Hnmt 5306.5 5055
Iars -5826.5 3615
Inmt 4854.5 -1704
Lars -3917.5 2785
Mars -5670.5 1573
Papss1 4509.5 -5279
Papss2 4802.5 -4026
Pstk -4403.5 5239
Qars -912.5 4779
Rars 1411.5 -2046
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Sars -5060.5 575
Scly -943.5 -5072
Secisbp2 -4620.5 857
Sephs2 4892.5 -4752
Sepsecs 3483.5 1508
Txnrd1 -5335.5 5116
Uba52 -2952.5 -3903





G-beta:gamma-signalling-through-CDC42

metric value
setSize 13
pMANOVA 0.0179
p.adjustMANOVA 0.0854
s.dist 0.477
s.ab 0.326
s.d36 -0.348
p.ab 0.0419
p.d36 0.0299




Gene ab d36
Gng2 5782.5 -5206
Cdc42 4469.5 -5470
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034

Click HERE to show all gene set members

ab d36
Arhgef6 -3829.5 1076
Cdc42 4469.5 -5470
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034





G-beta:gamma-signalling-through-PLC-beta

metric value
setSize 14
pMANOVA 0.0123
p.adjustMANOVA 0.0652
s.dist 0.476
s.ab 0.422
s.d36 -0.22
p.ab 0.00627
p.d36 0.155




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034
Plcb3 3157.5 -1110

Click HERE to show all gene set members

ab d36
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034
Plcb1 2787.5 2077
Plcb2 4464.5 3151
Plcb3 3157.5 -1110





Presynaptic-function-of-Kainate-receptors

metric value
setSize 14
pMANOVA 0.0123
p.adjustMANOVA 0.0652
s.dist 0.476
s.ab 0.422
s.d36 -0.22
p.ab 0.00627
p.d36 0.155




Gene ab d36
Gng2 5782.5 -5206
Gng10 5579.5 -4220
Gnb1 3791.5 -5197
Gnb4 3274.5 -5708
Gngt2 5414.5 -2034
Plcb3 3157.5 -1110

Click HERE to show all gene set members

ab d36
Gnb1 3791.5 -5197
Gnb2 -5587.5 -3631
Gnb3 -88.5 -839
Gnb4 3274.5 -5708
Gnb5 1823.5 3790
Gng10 5579.5 -4220
Gng11 -2523.5 -1939
Gng12 3603.5 954
Gng2 5782.5 -5206
Gng5 1661.5 505
Gngt2 5414.5 -2034
Plcb1 2787.5 2077
Plcb2 4464.5 3151
Plcb3 3157.5 -1110





Basigin-interactions

metric value
setSize 18
pMANOVA 0.00417
p.adjustMANOVA 0.0291
s.dist 0.473
s.ab 0.343
s.d36 -0.326
p.ab 0.0118
p.d36 0.0168




Gene ab d36
Cav1 4754.5 -5886
Slc3a2 4587.5 -5542
Atp1b3 5168.5 -4262
Slc7a6 4648.5 -4568
Slc16a3 3452.5 -5626
Atp1b2 3667.5 -5273
Slc7a5 4006.5 -3723
Slc7a7 5746.5 -1805
Ppia 808.5 -4794

Click HERE to show all gene set members

ab d36
Atp1b1 -150.5 3208
Atp1b2 3667.5 -5273
Atp1b3 5168.5 -4262
Bsg -3352.5 403
Cav1 4754.5 -5886
Itga3 4396.5 2383
Itga6 -4134.5 -5495
Itgb1 3540.5 3163
L1cam -2382.5 -3142
Ppia 808.5 -4794
Ppil2 -2307.5 2412
Slc16a1 -3831.5 892
Slc16a3 3452.5 -5626
Slc3a2 4587.5 -5542
Slc7a5 4006.5 -3723
Slc7a6 4648.5 -4568
Slc7a7 5746.5 -1805
Slc7a8 5528.5 1390





Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)

metric value
setSize 10
pMANOVA 0.0482
p.adjustMANOVA 0.171
s.dist 0.472
s.ab 0.351
s.d36 -0.315
p.ab 0.0548
p.d36 0.0846




Gene ab d36
Ptgs1 5675.5 -5659
Hpgd 5437.5 -4846
Ptgis 5113.5 -3525
Ptgds 4911.5 -2326
Tbxas1 1684.5 -3037
Akr1c14 2174.5 -1600

Click HERE to show all gene set members

ab d36
Akr1c14 2174.5 -1600
Cbr1 2721.5 1075
Hpgd 5437.5 -4846
Ptgds 4911.5 -2326
Ptges2 -1183.5 234
Ptges3 -4640.5 -2970
Ptgis 5113.5 -3525
Ptgr2 -2432.5 3120
Ptgs1 5675.5 -5659
Tbxas1 1684.5 -3037





Interferon-alpha/beta-signaling

metric value
setSize 35
pMANOVA 4.73e-06
p.adjustMANOVA 0.000133
s.dist 0.468
s.ab -0.144
s.d36 -0.445
p.ab 0.141
p.d36 5.18e-06




Gene ab d36
Bst2 -5888.5 -5996
Isg15 -5883.5 -5285
Oas2 -5540.5 -4990
Irf7 -4647.5 -5914
Rsad2 -5131.5 -4843
Stat2 -4139.5 -5921
Isg20 -5441.5 -3741
Ifi35 -4428.5 -4434
Irf2 -5873.5 -3194
Ifnar1 -2630.5 -5833
Usp18 -5444.5 -1927
Ifnar2 -2806.5 -3629
Ptpn6 -4724.5 -2054
Psmb8 -2315.5 -3885
Xaf1 -1862.5 -3693
Ifit2 -2736.5 -2298
Irf3 -1680.5 -2895
Irf8 -1276.5 -2982
Samhd1 -555.5 -1960

Click HERE to show all gene set members

ab d36
Abce1 -4552.5 2319
Adar 1807.5 -4432
Bst2 -5888.5 -5996
Egr1 4846.5 -1350
Ifi27 5358.5 -3694
Ifi35 -4428.5 -4434
Ifit2 -2736.5 -2298
Ifit3 3876.5 -1636
Ifnar1 -2630.5 -5833
Ifnar2 -2806.5 -3629
Ip6k2 4775.5 586
Irf1 3743.5 -4308
Irf2 -5873.5 -3194
Irf3 -1680.5 -2895
Irf5 3395.5 -3826
Irf7 -4647.5 -5914
Irf8 -1276.5 -2982
Irf9 1471.5 -5883
Isg15 -5883.5 -5285
Isg20 -5441.5 -3741
Jak1 -5522.5 3290
Oas2 -5540.5 -4990
Psmb8 -2315.5 -3885
Ptpn1 1809.5 -279
Ptpn11 1827.5 1935
Ptpn6 -4724.5 -2054
Rnasel 5083.5 -3416
Rsad2 -5131.5 -4843
Samhd1 -555.5 -1960
Socs3 3467.5 3794
Stat1 3505.5 -7
Stat2 -4139.5 -5921
Tyk2 3595.5 -2825
Usp18 -5444.5 -1927
Xaf1 -1862.5 -3693





Metabolism-of-nitric-oxide:-eNOS-activation-and-regulation

metric value
setSize 15
pMANOVA 0.00648
p.adjustMANOVA 0.0398
s.dist 0.467
s.ab -0.0461
s.d36 -0.464
p.ab 0.757
p.d36 0.00185




Gene ab d36
Cygb -2389.5 -4825
Nostrin -2021.5 -5623
Dnm2 -4101.5 -2206
Akt1 -4927.5 -1552
Hsp90aa1 -668.5 -4565
Ddah2 -24.5 -2037

Click HERE to show all gene set members

ab d36
Akt1 -4927.5 -1552
Calm1 1392.5 -5536
Cav1 4754.5 -5886
Cygb -2389.5 -4825
Ddah1 -4911.5 1178
Ddah2 -24.5 -2037
Dnm2 -4101.5 -2206
Hsp90aa1 -668.5 -4565
Lypla1 -35.5 2373
Nos3 3513.5 -5802
Nosip 2634.5 -2132
Nostrin -2021.5 -5623
Spr 602.5 -3175
Wasl -1485.5 2711
Zdhhc21 1540.5 -5484





MECP2-regulates-neuronal-receptors-and-channels

metric value
setSize 11
pMANOVA 0.0263
p.adjustMANOVA 0.113
s.dist 0.463
s.ab 0.462
s.d36 0.0407
p.ab 0.00803
p.d36 0.815




Gene ab d36
Ptpn4 5576.5 4306
Slc2a3 3495.5 1915
Hdac2 4934.5 618
Sin3a 2117.5 948
Mecp2 153.5 4573

Click HERE to show all gene set members

ab d36
Creb1 -4202.5 2261
Fkbp5 5664.5 -4095
Hdac1 5680.5 -2077
Hdac2 4934.5 618
Mecp2 153.5 4573
Notch1 2890.5 -3995
Ptpn1 1809.5 -279
Ptpn4 5576.5 4306
Sin3a 2117.5 948
Slc2a3 3495.5 1915
Trpc3 517.5 -2446





Caspase-mediated-cleavage-of-cytoskeletal-proteins

metric value
setSize 12
pMANOVA 0.023
p.adjustMANOVA 0.102
s.dist 0.462
s.ab 0.0607
s.d36 -0.458
p.ab 0.716
p.d36 0.00604




Gene ab d36
Vim 3629.5 -5658
Sptan1 3007.5 -5334
Casp3 2412.5 -4726
Casp6 4496.5 -1394
Casp8 944.5 -5712
Gsn 101.5 -4747

Click HERE to show all gene set members

ab d36
Add1 1065.5 5204
Casp3 2412.5 -4726
Casp6 4496.5 -1394
Casp7 -1335.5 -3120
Casp8 944.5 -5712
Dbnl -4869.5 -5726
Gas2 4279.5 780
Gsn 101.5 -4747
Mapt -4962.5 -4883
Plec -6071.5 1721
Sptan1 3007.5 -5334
Vim 3629.5 -5658





Scavenging-by-Class-A-Receptors

metric value
setSize 14
pMANOVA 0.00767
p.adjustMANOVA 0.0455
s.dist 0.461
s.ab -0.215
s.d36 -0.407
p.ab 0.163
p.d36 0.00832




Gene ab d36
Ftl1 -5672.5 -4192
Col4a1 -4700.5 -4897
Col4a2 -5585.5 -3480
Colec11 -1030.5 -5627
Scara5 -1328.5 -1894
Calr -1179.5 -2120
Col3a1 -1219.5 -1922
Fth1 -2174.5 -393
Col1a1 -571.5 -1205

Click HERE to show all gene set members

ab d36
Apoe 1800.5 -5065
Calr -1179.5 -2120
Col1a1 -571.5 -1205
Col1a2 585.5 -2063
Col3a1 -1219.5 -1922
Col4a1 -4700.5 -4897
Col4a2 -5585.5 -3480
Colec11 -1030.5 -5627
Colec12 4327.5 -2758
Fth1 -2174.5 -393
Ftl1 -5672.5 -4192
Hsp90b1 1963.5 -1630
Masp1 -4978.5 2243
Scara5 -1328.5 -1894





Peroxisomal-protein-import

metric value
setSize 52
pMANOVA 1.8e-07
p.adjustMANOVA 7.16e-06
s.dist 0.46
s.ab -0.157
s.d36 0.432
p.ab 0.0507
p.d36 7.11e-08




Gene ab d36
Dhrs4 -4704.5 5203
Ube2d1 -4742.5 4771
Acot2 -3528.5 5594
Nudt7 -3329.5 5773
Crat -2926.5 5772
Mlycd -2975.5 5299
Idh1 -3045.5 5095
Ide -2882.5 5146
Amacr -2719.5 5193
Pex12 -2684.5 4723
Crot -2245.5 4979
Pex7 -1753.5 5164
Paox -4685.5 1842
Pex6 -4277.5 1581
Pex2 -4600.5 1444
Ddo -1129.5 5697
Ephx2 -1020.5 5848
Hacl1 -2104.5 2166
Hmgcl -2497.5 1687
Ech1 -4002.5 938

Click HERE to show all gene set members

ab d36
Acot2 -3528.5 5594
Acot4 1084.5 -125
Acot8 -3903.5 -1738
Acox1 1182.5 5457
Acox3 3081.5 2431
Agps -2340.5 -440
Amacr -2719.5 5193
Cat 95.5 5567
Crat -2926.5 5772
Crot -2245.5 4979
Ddo -1129.5 5697
Decr2 359.5 -2504
Dhrs4 -4704.5 5203
Ech1 -4002.5 938
Ehhadh 2146.5 5711
Ephx2 -1020.5 5848
Gnpat 1173.5 4973
Gstk1 -1153.5 124
Hacl1 -2104.5 2166
Hmgcl -2497.5 1687
Hsd17b4 273.5 4650
Ide -2882.5 5146
Idh1 -3045.5 5095
Lonp2 -493.5 5405
Mlycd -2975.5 5299
Mpv17 -3580.5 -623
Nos2 -4783.5 -5692
Nudt19 4961.5 1526
Nudt7 -3329.5 5773
Paox -4685.5 1842
Pecr 1658.5 -575
Pex1 4455.5 3578
Pex10 321.5 3276
Pex12 -2684.5 4723
Pex13 4063.5 2706
Pex14 248.5 1366
Pex2 -4600.5 1444
Pex26 323.5 421
Pex5 -5172.5 -197
Pex6 -4277.5 1581
Pex7 -1753.5 5164
Phyh 1979.5 4810
Rps27a -4190.5 -4207
Scp2 5674.5 2752
Tysnd1 -1743.5 497
Uba52 -2952.5 -3903
Ubb -2267.5 -1407
Ube2d1 -4742.5 4771
Ube2d2a 5601.5 -410
Ube2d3 -1398.5 2087
Usp9x 2232.5 4874
Zfand6 -296.5 4130





Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)

metric value
setSize 92
pMANOVA 3.46e-13
p.adjustMANOVA 2.84e-11
s.dist 0.455
s.ab -0.00187
s.d36 -0.455
p.ab 0.975
p.d36 4.91e-14




Gene ab d36
Rpl13 -5343.5 -4462
Rplp2 -4360.5 -4986
Rps16 -3846.5 -5414
Rpl41 -4354.5 -4635
Rpl28 -5186.5 -3868
Rpl5 -4969.5 -3931
Rpl15 -5749.5 -3305
Rps27a -4190.5 -4207
Rpl34 -3795.5 -3996
Rplp0 -5643.5 -2660
Rpl27a -3414.5 -4219
Rpl35 -3665.5 -3928
Rpl30 -3228.5 -4370
Rps5 -3589.5 -3763
Rpl32 -3143.5 -4101
Rps19 -3084.5 -4163
Uba52 -2952.5 -3903
Rplp1 -2371.5 -4419
Rpl29 -3224.5 -3135
Rpl12 -3318.5 -2902

Click HERE to show all gene set members

ab d36
Casc3 -4271.5 -1111
Dcp1a 3413.5 -4671
Eif4a3 2916.5 -2359
Eif4g1 -2207.5 3277
Etf1 -2724.5 2042
Flt3l 2020.5 -3039
Gspt1 -3382.5 2577
Magoh -3961.5 -1683
Magohb -3534.5 -2051
Ncbp1 -1856.5 -2759
Ncbp2 335.5 -250
Pnrc2 5361.5 -2890
Ppp2ca 1855.5 200
Ppp2r1a -2019.5 2680
Ppp2r2a -2405.5 2903
Rnps1 -1184.5 1620
Rpl10a -1941.5 -4929
Rpl11 -2529.5 -3606
Rpl12 -3318.5 -2902
Rpl13 -5343.5 -4462
Rpl14 4942.5 -2991
Rpl15 -5749.5 -3305
Rpl18 -1996.5 -4127
Rpl18a -1154.5 -3833
Rpl19 -1709.5 -4384
Rpl22 4995.5 -4324
Rpl22l1 3523.5 -5282
Rpl23 5208.5 -4021
Rpl23a 4038.5 -1192
Rpl24 2546.5 -3508
Rpl26 4899.5 -4289
Rpl27-ps3 5035.5 -2001
Rpl27a -3414.5 -4219
Rpl28 -5186.5 -3868
Rpl29 -3224.5 -3135
Rpl3 4229.5 -5770
Rpl30 -3228.5 -4370
Rpl32 -3143.5 -4101
Rpl34 -3795.5 -3996
Rpl35 -3665.5 -3928
Rpl36al -1509.5 -5050
Rpl37 -2597.5 -2588
Rpl37a 50.5 -4031
Rpl38 3088.5 -4166
Rpl39 1032.5 -4810
Rpl3l -4110.5 2642
Rpl4 5629.5 -3114
Rpl41 -4354.5 -4635
Rpl5 -4969.5 -3931
Rpl6 1461.5 -3217
Rpl8 -883.5 -4630
Rplp0 -5643.5 -2660
Rplp1 -2371.5 -4419
Rplp2 -4360.5 -4986
Rps11 392.5 -3904
Rps13 -495.5 -3412
Rps14 -186.5 -4375
Rps15a -3535.5 -2229
Rps16 -3846.5 -5414
Rps17 -1442.5 -4621
Rps18 607.5 -4200
Rps19 -3084.5 -4163
Rps20 5084.5 -5300
Rps21 -2041.5 -3684
Rps23 5402.5 -5063
Rps24 4956.5 -3149
Rps25 4129.5 -3204
Rps26 2173.5 -4049
Rps27 1294.5 -4744
Rps27a -4190.5 -4207
Rps27l 3129.5 -3066
Rps29 -684.5 -4455
Rps3 -321.5 -4333
Rps3a1 4558.5 -4165
Rps4x 5645.5 -4580
Rps5 -3589.5 -3763
Rps6 5412.5 -3069
Rps7 2833.5 -3831
Rps8 4049.5 -3452
Rps9 -1967.5 -4122
Rpsa -1204.5 -4470
Smg1 -411.5 -4204
Smg5 818.5 4017
Smg6 -299.5 5247
Smg7 3889.5 -84
Smg8 -4635.5 2270
Smg9 -1571.5 -5550
Uba52 -2952.5 -3903
Upf1 -675.5 1867
Upf2 5290.5 757
Upf3a -373.5 2500
Upf3b 5572.5 -497





Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.0 (2020-04-24)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /mnt/md0/app/R-4.0.0/lib/libRblas.so
## LAPACK: /mnt/md0/app/R-4.0.0/lib/libRlapack.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_1.5.0               
##  [3] ggplot2_3.3.1               reshape2_1.4.4             
##  [5] beeswarm_0.2.3              gplots_3.0.3               
##  [7] gtools_3.8.2                tibble_3.0.1               
##  [9] dplyr_1.0.0                 echarts4r_0.2.3            
## [11] mitch_1.0.4                 DESeq2_1.28.1              
## [13] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [15] matrixStats_0.56.0          Biobase_2.48.0             
## [17] GenomicRanges_1.40.0        GenomeInfoDb_1.24.0        
## [19] IRanges_2.22.2              S4Vectors_0.26.1           
## [21] BiocGenerics_0.34.0        
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_0.9-7            RColorBrewer_1.1-2    
##  [4] rprojroot_1.3-2        tools_4.0.0            backports_1.1.7       
##  [7] R6_2.4.1               KernSmooth_2.23-17     DBI_1.1.0             
## [10] colorspace_1.4-1       withr_2.2.0            tidyselect_1.1.0      
## [13] gridExtra_2.3          bit_1.1-15.2           compiler_4.0.0        
## [16] desc_1.2.0             labeling_0.3           caTools_1.18.0        
## [19] scales_1.1.1           genefilter_1.70.0      stringr_1.4.0         
## [22] digest_0.6.25          rmarkdown_2.2          XVector_0.28.0        
## [25] pkgconfig_2.0.3        htmltools_0.4.0        fastmap_1.0.1         
## [28] highr_0.8              htmlwidgets_1.5.1      rlang_0.4.6           
## [31] RSQLite_2.2.0          shiny_1.4.0.2          farver_2.0.3          
## [34] generics_0.0.2         jsonlite_1.6.1         BiocParallel_1.22.0   
## [37] RCurl_1.98-1.2         magrittr_1.5           GenomeInfoDbData_1.2.3
## [40] Matrix_1.2-18          Rcpp_1.0.4.6           munsell_0.5.0         
## [43] lifecycle_0.2.0        stringi_1.4.6          yaml_2.2.1            
## [46] MASS_7.3-51.6          zlibbioc_1.34.0        plyr_1.8.6            
## [49] grid_4.0.0             blob_1.2.1             gdata_2.18.0          
## [52] promises_1.1.0         crayon_1.3.4           lattice_0.20-41       
## [55] splines_4.0.0          annotate_1.66.0        locfit_1.5-9.4        
## [58] knitr_1.28             pillar_1.4.4           geneplotter_1.66.0    
## [61] XML_3.99-0.3           glue_1.4.1             evaluate_0.14         
## [64] vctrs_0.3.0            httpuv_1.5.3.1         testthat_2.3.2        
## [67] gtable_0.3.0           purrr_0.3.4            reshape_0.8.8         
## [70] assertthat_0.2.1       xfun_0.14              mime_0.9              
## [73] xtable_1.8-4           later_1.0.0            survival_3.1-12       
## [76] pbmcapply_1.5.0        AnnotationDbi_1.50.0   memoise_1.1.0         
## [79] ellipsis_0.3.1

END of report