Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-09-07
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## Sed Ex
## 0610009B22Rik 1.6344600 1.1168615
## 0610009L18Rik 1.0145872 0.2160756
## 0610010K14Rik 0.1633529 0.6692320
## 0610012G03Rik 0.5937955 0.4088542
## 0610030E20Rik -0.7027218 0.2111877
## 0610040J01Rik -0.0895336 -1.4975473| Profile metrics | |
|---|---|
| num_genes_in_profile | 9258 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 2754 |
| num_profile_genes_not_in_sets | 6504 |
| profile_pearson_correl | -0.04768 |
| profile_spearman_correl | -0.029 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 674 |
| num_genesets_excluded | 217 |
| num_genesets_included | 457 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 90 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.Sed | s.Ex | p.Sed | p.Ex |
|---|---|---|---|---|---|---|---|---|
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 1.93e-06 | 6.79e-05 | 0.833 | 0.5210 | -0.65000 | 1.15e-03 | 4.94e-05 |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 5.89e-06 | 1.80e-04 | 0.819 | 0.8180 | -0.04000 | 9.26e-07 | 8.11e-01 |
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 3.08e-06 | 1.01e-04 | 0.677 | 0.5580 | -0.38200 | 2.52e-05 | 3.96e-03 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 7.02e-04 | 7.29e-03 | 0.672 | 0.5810 | -0.33700 | 8.42e-04 | 5.33e-02 |
| REACTOME COMPLEMENT CASCADE | 10 | 1.65e-03 | 1.37e-02 | 0.662 | -0.5820 | 0.31500 | 1.45e-03 | 8.45e-02 |
| REACTOME PYRUVATE METABOLISM | 16 | 4.69e-05 | 1.13e-03 | 0.651 | 0.6020 | -0.24800 | 3.05e-05 | 8.62e-02 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 3.19e-20 | 7.28e-18 | 0.642 | 0.6410 | -0.03740 | 2.75e-21 | 5.82e-01 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 3.42e-16 | 5.21e-14 | 0.636 | 0.6350 | -0.04540 | 3.40e-17 | 5.47e-01 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 9.80e-26 | 4.48e-23 | 0.604 | 0.5910 | -0.12700 | 5.08e-26 | 2.38e-02 |
| REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | 13 | 1.20e-03 | 1.08e-02 | 0.594 | -0.5300 | 0.26900 | 9.45e-04 | 9.30e-02 |
| REACTOME PEPTIDE CHAIN ELONGATION | 66 | 2.95e-15 | 3.37e-13 | 0.589 | -0.5280 | 0.26000 | 1.19e-13 | 2.61e-04 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 4.73e-09 | 1.97e-07 | 0.588 | 0.4980 | -0.31200 | 1.08e-07 | 8.73e-04 |
| REACTOME G PROTEIN ACTIVATION | 10 | 9.02e-03 | 4.58e-02 | 0.553 | -0.4700 | -0.29200 | 1.01e-02 | 1.10e-01 |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 6.16e-03 | 3.52e-02 | 0.552 | 0.1360 | 0.53400 | 4.34e-01 | 2.15e-03 |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 11 | 6.66e-03 | 3.76e-02 | 0.544 | -0.3390 | -0.42500 | 5.18e-02 | 1.47e-02 |
| REACTOME CALNEXIN CALRETICULIN CYCLE | 11 | 8.86e-03 | 4.55e-02 | 0.540 | -0.5170 | 0.15600 | 3.02e-03 | 3.71e-01 |
| REACTOME METABOLISM OF POLYAMINES | 12 | 4.65e-03 | 2.91e-02 | 0.539 | 0.4600 | 0.28100 | 5.76e-03 | 9.20e-02 |
| REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | 11 | 7.42e-03 | 4.01e-02 | 0.538 | -0.4170 | -0.33900 | 1.66e-02 | 5.15e-02 |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 11 | 7.49e-03 | 4.01e-02 | 0.537 | -0.3390 | -0.41600 | 5.15e-02 | 1.68e-02 |
| REACTOME NCAM1 INTERACTIONS | 15 | 2.03e-03 | 1.60e-02 | 0.530 | -0.1970 | 0.49300 | 1.87e-01 | 9.61e-04 |
| REACTOME INTERFERON GAMMA SIGNALING | 24 | 9.70e-05 | 1.93e-03 | 0.514 | -0.3500 | 0.37700 | 2.98e-03 | 1.41e-03 |
| REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | 20 | 5.48e-04 | 6.23e-03 | 0.499 | 0.0595 | 0.49500 | 6.45e-01 | 1.27e-04 |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 88 | 1.84e-14 | 1.68e-12 | 0.497 | -0.4310 | 0.24800 | 3.12e-12 | 5.90e-05 |
| REACTOME TRAFFICKING OF AMPA RECEPTORS | 16 | 2.65e-03 | 1.92e-02 | 0.497 | 0.0285 | 0.49600 | 8.43e-01 | 5.99e-04 |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 12 | 1.39e-02 | 6.44e-02 | 0.481 | -0.2760 | -0.39300 | 9.74e-02 | 1.83e-02 |
| REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | 16 | 3.92e-03 | 2.52e-02 | 0.474 | -0.3990 | -0.25700 | 5.79e-03 | 7.49e-02 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 41 | 1.60e-06 | 6.10e-05 | 0.472 | -0.4280 | 0.19700 | 2.11e-06 | 2.90e-02 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 82 | 4.68e-12 | 3.56e-10 | 0.467 | -0.4280 | 0.18600 | 2.20e-11 | 3.67e-03 |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 10 | 3.65e-02 | 1.28e-01 | 0.463 | -0.3750 | -0.27300 | 4.03e-02 | 1.35e-01 |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 84 | 1.60e-11 | 1.05e-09 | 0.451 | -0.4070 | 0.19400 | 1.28e-10 | 2.13e-03 |
| REACTOME SIGNAL AMPLIFICATION | 14 | 1.26e-02 | 6.06e-02 | 0.450 | -0.3480 | -0.28600 | 2.43e-02 | 6.44e-02 |
| REACTOME TCR SIGNALING | 28 | 2.32e-04 | 3.53e-03 | 0.443 | -0.4260 | -0.12400 | 9.78e-05 | 2.56e-01 |
| REACTOME STRIATED MUSCLE CONTRACTION | 22 | 2.17e-03 | 1.65e-02 | 0.438 | 0.3510 | -0.26200 | 4.42e-03 | 3.38e-02 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | 16 | 1.23e-02 | 5.96e-02 | 0.435 | 0.3120 | -0.30200 | 3.06e-02 | 3.63e-02 |
| REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 14 | 2.23e-02 | 9.19e-02 | 0.424 | -0.4190 | -0.06370 | 6.65e-03 | 6.80e-01 |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 85 | 2.47e-10 | 1.13e-08 | 0.423 | -0.3810 | 0.18300 | 1.37e-09 | 3.58e-03 |
| REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | 10 | 8.22e-02 | 2.13e-01 | 0.414 | -0.3410 | 0.23500 | 6.21e-02 | 1.99e-01 |
| REACTOME GLUTATHIONE CONJUGATION | 12 | 5.64e-02 | 1.82e-01 | 0.405 | 0.3570 | -0.19000 | 3.21e-02 | 2.56e-01 |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 10 | 1.00e-01 | 2.41e-01 | 0.394 | 0.3890 | -0.05750 | 3.31e-02 | 7.53e-01 |
| REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | 18 | 1.44e-02 | 6.57e-02 | 0.392 | -0.3590 | -0.15800 | 8.33e-03 | 2.47e-01 |
| REACTOME INFLUENZA LIFE CYCLE | 113 | 2.35e-11 | 1.34e-09 | 0.387 | -0.3310 | 0.20100 | 1.39e-09 | 2.43e-04 |
| REACTOME BASE EXCISION REPAIR | 12 | 7.75e-02 | 2.10e-01 | 0.381 | -0.3460 | 0.15900 | 3.78e-02 | 3.39e-01 |
| REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | 18 | 2.35e-02 | 9.33e-02 | 0.378 | 0.3140 | -0.21100 | 2.12e-02 | 1.22e-01 |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 13 | 5.74e-02 | 1.82e-01 | 0.378 | -0.3150 | -0.20900 | 4.94e-02 | 1.92e-01 |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 13 | 7.02e-02 | 2.01e-01 | 0.374 | -0.2270 | 0.29800 | 1.57e-01 | 6.29e-02 |
| REACTOME RAP1 SIGNALLING | 12 | 8.29e-02 | 2.13e-01 | 0.372 | -0.3720 | -0.00799 | 2.58e-02 | 9.62e-01 |
| REACTOME MITOCHONDRIAL PROTEIN IMPORT | 42 | 2.29e-04 | 3.53e-03 | 0.370 | 0.3260 | -0.17500 | 2.64e-04 | 4.96e-02 |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 43 | 1.26e-04 | 2.22e-03 | 0.368 | 0.2770 | 0.24200 | 1.66e-03 | 6.02e-03 |
| REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 17 | 2.88e-02 | 1.08e-01 | 0.368 | -0.2970 | -0.21700 | 3.40e-02 | 1.21e-01 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 10 | 1.30e-01 | 2.91e-01 | 0.364 | -0.2060 | -0.30000 | 2.61e-01 | 1.00e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.Sed | s.Ex | p.Sed | p.Ex |
|---|---|---|---|---|---|---|---|---|
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 1.93e-06 | 6.79e-05 | 0.83300 | 0.52100 | -0.65000 | 1.15e-03 | 4.94e-05 |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 5.89e-06 | 1.80e-04 | 0.81900 | 0.81800 | -0.04000 | 9.26e-07 | 8.11e-01 |
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 3.08e-06 | 1.01e-04 | 0.67700 | 0.55800 | -0.38200 | 2.52e-05 | 3.96e-03 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 7.02e-04 | 7.29e-03 | 0.67200 | 0.58100 | -0.33700 | 8.42e-04 | 5.33e-02 |
| REACTOME COMPLEMENT CASCADE | 10 | 1.65e-03 | 1.37e-02 | 0.66200 | -0.58200 | 0.31500 | 1.45e-03 | 8.45e-02 |
| REACTOME PYRUVATE METABOLISM | 16 | 4.69e-05 | 1.13e-03 | 0.65100 | 0.60200 | -0.24800 | 3.05e-05 | 8.62e-02 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 3.19e-20 | 7.28e-18 | 0.64200 | 0.64100 | -0.03740 | 2.75e-21 | 5.82e-01 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 3.42e-16 | 5.21e-14 | 0.63600 | 0.63500 | -0.04540 | 3.40e-17 | 5.47e-01 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 9.80e-26 | 4.48e-23 | 0.60400 | 0.59100 | -0.12700 | 5.08e-26 | 2.38e-02 |
| REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | 13 | 1.20e-03 | 1.08e-02 | 0.59400 | -0.53000 | 0.26900 | 9.45e-04 | 9.30e-02 |
| REACTOME PEPTIDE CHAIN ELONGATION | 66 | 2.95e-15 | 3.37e-13 | 0.58900 | -0.52800 | 0.26000 | 1.19e-13 | 2.61e-04 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 4.73e-09 | 1.97e-07 | 0.58800 | 0.49800 | -0.31200 | 1.08e-07 | 8.73e-04 |
| REACTOME G PROTEIN ACTIVATION | 10 | 9.02e-03 | 4.58e-02 | 0.55300 | -0.47000 | -0.29200 | 1.01e-02 | 1.10e-01 |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 6.16e-03 | 3.52e-02 | 0.55200 | 0.13600 | 0.53400 | 4.34e-01 | 2.15e-03 |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 11 | 6.66e-03 | 3.76e-02 | 0.54400 | -0.33900 | -0.42500 | 5.18e-02 | 1.47e-02 |
| REACTOME CALNEXIN CALRETICULIN CYCLE | 11 | 8.86e-03 | 4.55e-02 | 0.54000 | -0.51700 | 0.15600 | 3.02e-03 | 3.71e-01 |
| REACTOME METABOLISM OF POLYAMINES | 12 | 4.65e-03 | 2.91e-02 | 0.53900 | 0.46000 | 0.28100 | 5.76e-03 | 9.20e-02 |
| REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | 11 | 7.42e-03 | 4.01e-02 | 0.53800 | -0.41700 | -0.33900 | 1.66e-02 | 5.15e-02 |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 11 | 7.49e-03 | 4.01e-02 | 0.53700 | -0.33900 | -0.41600 | 5.15e-02 | 1.68e-02 |
| REACTOME NCAM1 INTERACTIONS | 15 | 2.03e-03 | 1.60e-02 | 0.53000 | -0.19700 | 0.49300 | 1.87e-01 | 9.61e-04 |
| REACTOME INTERFERON GAMMA SIGNALING | 24 | 9.70e-05 | 1.93e-03 | 0.51400 | -0.35000 | 0.37700 | 2.98e-03 | 1.41e-03 |
| REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | 20 | 5.48e-04 | 6.23e-03 | 0.49900 | 0.05950 | 0.49500 | 6.45e-01 | 1.27e-04 |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 88 | 1.84e-14 | 1.68e-12 | 0.49700 | -0.43100 | 0.24800 | 3.12e-12 | 5.90e-05 |
| REACTOME TRAFFICKING OF AMPA RECEPTORS | 16 | 2.65e-03 | 1.92e-02 | 0.49700 | 0.02850 | 0.49600 | 8.43e-01 | 5.99e-04 |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 12 | 1.39e-02 | 6.44e-02 | 0.48100 | -0.27600 | -0.39300 | 9.74e-02 | 1.83e-02 |
| REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | 16 | 3.92e-03 | 2.52e-02 | 0.47400 | -0.39900 | -0.25700 | 5.79e-03 | 7.49e-02 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 41 | 1.60e-06 | 6.10e-05 | 0.47200 | -0.42800 | 0.19700 | 2.11e-06 | 2.90e-02 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 82 | 4.68e-12 | 3.56e-10 | 0.46700 | -0.42800 | 0.18600 | 2.20e-11 | 3.67e-03 |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 10 | 3.65e-02 | 1.28e-01 | 0.46300 | -0.37500 | -0.27300 | 4.03e-02 | 1.35e-01 |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 84 | 1.60e-11 | 1.05e-09 | 0.45100 | -0.40700 | 0.19400 | 1.28e-10 | 2.13e-03 |
| REACTOME SIGNAL AMPLIFICATION | 14 | 1.26e-02 | 6.06e-02 | 0.45000 | -0.34800 | -0.28600 | 2.43e-02 | 6.44e-02 |
| REACTOME TCR SIGNALING | 28 | 2.32e-04 | 3.53e-03 | 0.44300 | -0.42600 | -0.12400 | 9.78e-05 | 2.56e-01 |
| REACTOME STRIATED MUSCLE CONTRACTION | 22 | 2.17e-03 | 1.65e-02 | 0.43800 | 0.35100 | -0.26200 | 4.42e-03 | 3.38e-02 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | 16 | 1.23e-02 | 5.96e-02 | 0.43500 | 0.31200 | -0.30200 | 3.06e-02 | 3.63e-02 |
| REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 14 | 2.23e-02 | 9.19e-02 | 0.42400 | -0.41900 | -0.06370 | 6.65e-03 | 6.80e-01 |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 85 | 2.47e-10 | 1.13e-08 | 0.42300 | -0.38100 | 0.18300 | 1.37e-09 | 3.58e-03 |
| REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | 10 | 8.22e-02 | 2.13e-01 | 0.41400 | -0.34100 | 0.23500 | 6.21e-02 | 1.99e-01 |
| REACTOME GLUTATHIONE CONJUGATION | 12 | 5.64e-02 | 1.82e-01 | 0.40500 | 0.35700 | -0.19000 | 3.21e-02 | 2.56e-01 |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 10 | 1.00e-01 | 2.41e-01 | 0.39400 | 0.38900 | -0.05750 | 3.31e-02 | 7.53e-01 |
| REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | 18 | 1.44e-02 | 6.57e-02 | 0.39200 | -0.35900 | -0.15800 | 8.33e-03 | 2.47e-01 |
| REACTOME INFLUENZA LIFE CYCLE | 113 | 2.35e-11 | 1.34e-09 | 0.38700 | -0.33100 | 0.20100 | 1.39e-09 | 2.43e-04 |
| REACTOME BASE EXCISION REPAIR | 12 | 7.75e-02 | 2.10e-01 | 0.38100 | -0.34600 | 0.15900 | 3.78e-02 | 3.39e-01 |
| REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | 18 | 2.35e-02 | 9.33e-02 | 0.37800 | 0.31400 | -0.21100 | 2.12e-02 | 1.22e-01 |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 13 | 5.74e-02 | 1.82e-01 | 0.37800 | -0.31500 | -0.20900 | 4.94e-02 | 1.92e-01 |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 13 | 7.02e-02 | 2.01e-01 | 0.37400 | -0.22700 | 0.29800 | 1.57e-01 | 6.29e-02 |
| REACTOME RAP1 SIGNALLING | 12 | 8.29e-02 | 2.13e-01 | 0.37200 | -0.37200 | -0.00799 | 2.58e-02 | 9.62e-01 |
| REACTOME MITOCHONDRIAL PROTEIN IMPORT | 42 | 2.29e-04 | 3.53e-03 | 0.37000 | 0.32600 | -0.17500 | 2.64e-04 | 4.96e-02 |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 43 | 1.26e-04 | 2.22e-03 | 0.36800 | 0.27700 | 0.24200 | 1.66e-03 | 6.02e-03 |
| REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 17 | 2.88e-02 | 1.08e-01 | 0.36800 | -0.29700 | -0.21700 | 3.40e-02 | 1.21e-01 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 10 | 1.30e-01 | 2.91e-01 | 0.36400 | -0.20600 | -0.30000 | 2.61e-01 | 1.00e-01 |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 19 | 2.08e-02 | 8.74e-02 | 0.36400 | -0.28200 | -0.22900 | 3.32e-02 | 8.41e-02 |
| REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 48 | 1.05e-04 | 2.00e-03 | 0.36200 | -0.32000 | 0.16800 | 1.27e-04 | 4.38e-02 |
| REACTOME GLYCOSPHINGOLIPID METABOLISM | 19 | 2.30e-02 | 9.31e-02 | 0.36000 | -0.32400 | -0.15700 | 1.46e-02 | 2.35e-01 |
| REACTOME EFFECTS OF PIP2 HYDROLYSIS | 13 | 8.04e-02 | 2.13e-01 | 0.35800 | -0.35500 | -0.04860 | 2.68e-02 | 7.62e-01 |
| REACTOME TRANSLATION | 123 | 1.27e-10 | 6.45e-09 | 0.35800 | -0.30800 | 0.18200 | 4.00e-09 | 5.16e-04 |
| REACTOME TRNA AMINOACYLATION | 39 | 5.58e-04 | 6.23e-03 | 0.35600 | 0.08750 | 0.34500 | 3.45e-01 | 1.96e-04 |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 17 | 3.83e-02 | 1.33e-01 | 0.35600 | 0.07810 | 0.34700 | 5.77e-01 | 1.33e-02 |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 40 | 4.79e-04 | 6.08e-03 | 0.35200 | 0.23000 | 0.26700 | 1.19e-02 | 3.52e-03 |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 15 | 5.77e-02 | 1.82e-01 | 0.35200 | -0.15900 | -0.31400 | 2.87e-01 | 3.52e-02 |
| REACTOME SYNTHESIS OF PA | 10 | 1.66e-01 | 3.41e-01 | 0.35100 | 0.28900 | -0.20000 | 1.14e-01 | 2.74e-01 |
| REACTOME DOWNSTREAM TCR SIGNALING | 20 | 2.34e-02 | 9.33e-02 | 0.35100 | -0.33100 | -0.11700 | 1.05e-02 | 3.64e-01 |
| REACTOME PLATELET AGGREGATION PLUG FORMATION | 18 | 3.37e-02 | 1.24e-01 | 0.34900 | -0.25800 | -0.23500 | 5.78e-02 | 8.43e-02 |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 43 | 3.38e-04 | 4.68e-03 | 0.34800 | 0.23800 | 0.25300 | 6.90e-03 | 4.15e-03 |
| REACTOME GLUCONEOGENESIS | 18 | 3.62e-02 | 1.28e-01 | 0.34700 | 0.31600 | 0.14300 | 2.03e-02 | 2.94e-01 |
| REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 16 | 5.42e-02 | 1.78e-01 | 0.34700 | -0.34100 | -0.06480 | 1.83e-02 | 6.54e-01 |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 46 | 2.11e-04 | 3.44e-03 | 0.34600 | 0.22300 | 0.26500 | 9.02e-03 | 1.92e-03 |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 42 | 5.37e-04 | 6.23e-03 | 0.34100 | 0.24300 | 0.24000 | 6.53e-03 | 7.22e-03 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 16 | 6.08e-02 | 1.87e-01 | 0.34000 | 0.05650 | 0.33500 | 6.96e-01 | 2.02e-02 |
| REACTOME DESTABILIZATION OF MRNA BY BRF1 | 15 | 7.10e-02 | 2.02e-01 | 0.33900 | -0.30500 | -0.14800 | 4.10e-02 | 3.20e-01 |
| REACTOME TELOMERE MAINTENANCE | 20 | 3.50e-02 | 1.28e-01 | 0.33800 | -0.30900 | 0.13800 | 1.69e-02 | 2.86e-01 |
| REACTOME PHASE II CONJUGATION | 24 | 1.88e-02 | 8.01e-02 | 0.33700 | 0.25700 | -0.21800 | 2.93e-02 | 6.41e-02 |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 42 | 6.68e-04 | 7.10e-03 | 0.33600 | 0.22600 | 0.24900 | 1.14e-02 | 5.24e-03 |
| REACTOME INTERFERON ALPHA BETA SIGNALING | 17 | 6.11e-02 | 1.87e-01 | 0.33400 | -0.31300 | 0.11700 | 2.53e-02 | 4.05e-01 |
| REACTOME LAGGING STRAND SYNTHESIS | 10 | 1.99e-01 | 3.89e-01 | 0.33300 | -0.27700 | 0.18400 | 1.29e-01 | 3.14e-01 |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 42 | 8.42e-04 | 8.01e-03 | 0.33100 | 0.19900 | 0.26500 | 2.57e-02 | 3.04e-03 |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 42 | 9.15e-04 | 8.54e-03 | 0.32900 | 0.20900 | 0.25400 | 1.90e-02 | 4.45e-03 |
| REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | 22 | 2.81e-02 | 1.07e-01 | 0.32700 | -0.31400 | -0.09040 | 1.08e-02 | 4.63e-01 |
| REACTOME SIGNALING BY NODAL | 11 | 1.89e-01 | 3.74e-01 | 0.32100 | 0.12500 | -0.29600 | 4.74e-01 | 8.93e-02 |
| REACTOME POTASSIUM CHANNELS | 21 | 4.25e-02 | 1.45e-01 | 0.32100 | 0.28300 | -0.15100 | 2.49e-02 | 2.31e-01 |
| REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 21 | 3.88e-02 | 1.33e-01 | 0.32000 | -0.03180 | -0.31900 | 8.01e-01 | 1.15e-02 |
| REACTOME SMOOTH MUSCLE CONTRACTION | 18 | 6.11e-02 | 1.87e-01 | 0.31900 | -0.09460 | -0.30500 | 4.87e-01 | 2.52e-02 |
| REACTOME MUSCLE CONTRACTION | 36 | 4.86e-03 | 3.00e-02 | 0.31900 | 0.17000 | -0.27000 | 7.83e-02 | 5.15e-03 |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 24 | 2.82e-02 | 1.07e-01 | 0.31900 | 0.29100 | -0.13000 | 1.38e-02 | 2.69e-01 |
| REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | 15 | 9.95e-02 | 2.41e-01 | 0.31800 | -0.10200 | -0.30100 | 4.93e-01 | 4.39e-02 |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 45 | 9.75e-04 | 8.91e-03 | 0.31700 | 0.19500 | 0.25000 | 2.39e-02 | 3.81e-03 |
| REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | 18 | 7.37e-02 | 2.04e-01 | 0.31500 | 0.27500 | -0.15400 | 4.36e-02 | 2.60e-01 |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 13 | 1.44e-01 | 3.11e-01 | 0.31300 | -0.30300 | -0.07730 | 5.83e-02 | 6.29e-01 |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 22 | 3.83e-02 | 1.33e-01 | 0.31000 | -0.19100 | -0.24500 | 1.22e-01 | 4.71e-02 |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 45 | 1.34e-03 | 1.13e-02 | 0.30900 | 0.24600 | 0.18800 | 4.35e-03 | 2.97e-02 |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 53 | 4.51e-04 | 5.88e-03 | 0.30800 | 0.16500 | 0.26000 | 3.83e-02 | 1.07e-03 |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 40 | 2.97e-03 | 2.02e-02 | 0.30800 | 0.20000 | 0.23400 | 2.87e-02 | 1.07e-02 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 56 | 3.20e-04 | 4.56e-03 | 0.30600 | 0.17000 | 0.25500 | 2.80e-02 | 1.00e-03 |
| REACTOME LYSOSOME VESICLE BIOGENESIS | 17 | 9.27e-02 | 2.33e-01 | 0.30400 | -0.30200 | -0.04070 | 3.13e-02 | 7.72e-01 |
| REACTOME GLUCOSE METABOLISM | 43 | 2.24e-03 | 1.65e-02 | 0.30400 | 0.23200 | 0.19600 | 8.65e-03 | 2.60e-02 |
| REACTOME PLATELET HOMEOSTASIS | 32 | 1.20e-02 | 5.89e-02 | 0.30300 | -0.03870 | -0.30000 | 7.05e-01 | 3.30e-03 |
| REACTOME EGFR DOWNREGULATION | 23 | 4.70e-02 | 1.57e-01 | 0.30200 | -0.19400 | 0.23200 | 1.08e-01 | 5.44e-02 |
| REACTOME DNA STRAND ELONGATION | 14 | 1.58e-01 | 3.31e-01 | 0.30100 | -0.23000 | 0.19300 | 1.36e-01 | 2.10e-01 |
| REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | 19 | 7.68e-02 | 2.10e-01 | 0.30000 | -0.00350 | 0.30000 | 9.79e-01 | 2.35e-02 |
| REACTOME GLUCOSE TRANSPORT | 29 | 1.81e-02 | 7.78e-02 | 0.30000 | 0.16500 | 0.25100 | 1.24e-01 | 1.96e-02 |
| REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 13 | 1.81e-01 | 3.64e-01 | 0.30000 | -0.16100 | 0.25300 | 3.14e-01 | 1.14e-01 |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 60 | 2.71e-04 | 3.99e-03 | 0.29900 | 0.17200 | 0.24500 | 2.16e-02 | 1.07e-03 |
| REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 15 | 1.35e-01 | 2.97e-01 | 0.29800 | -0.00112 | 0.29800 | 9.94e-01 | 4.55e-02 |
| REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 10 | 2.58e-01 | 4.55e-01 | 0.29700 | -0.14900 | -0.25600 | 4.13e-01 | 1.60e-01 |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 56 | 5.18e-04 | 6.23e-03 | 0.29700 | 0.17400 | 0.24100 | 2.50e-02 | 1.86e-03 |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 49 | 1.34e-03 | 1.13e-02 | 0.29700 | 0.16800 | 0.24400 | 4.20e-02 | 3.12e-03 |
| REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | 11 | 2.28e-01 | 4.21e-01 | 0.29600 | 0.13000 | 0.26600 | 4.57e-01 | 1.26e-01 |
| REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | 13 | 1.82e-01 | 3.64e-01 | 0.29200 | 0.26000 | 0.13400 | 1.05e-01 | 4.02e-01 |
| REACTOME ION CHANNEL TRANSPORT | 18 | 9.66e-02 | 2.39e-01 | 0.29200 | -0.07060 | -0.28400 | 6.04e-01 | 3.72e-02 |
| REACTOME PLATELET SENSITIZATION BY LDL | 11 | 2.35e-01 | 4.30e-01 | 0.29200 | -0.16300 | -0.24300 | 3.51e-01 | 1.63e-01 |
| REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | 42 | 5.33e-03 | 3.17e-02 | 0.29200 | 0.13900 | -0.25700 | 1.20e-01 | 3.96e-03 |
| REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | 22 | 6.45e-02 | 1.93e-01 | 0.29200 | -0.11400 | 0.26800 | 3.55e-01 | 2.95e-02 |
| REACTOME REGULATION OF APOPTOSIS | 48 | 1.91e-03 | 1.53e-02 | 0.29100 | 0.17200 | 0.23500 | 3.99e-02 | 4.82e-03 |
| REACTOME MRNA SPLICING MINOR PATHWAY | 39 | 7.65e-03 | 4.01e-02 | 0.29100 | -0.28000 | 0.07880 | 2.47e-03 | 3.95e-01 |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 21 | 6.74e-02 | 1.96e-01 | 0.28900 | -0.16500 | -0.23700 | 1.92e-01 | 5.99e-02 |
| REACTOME MHC CLASS II ANTIGEN PRESENTATION | 60 | 7.35e-04 | 7.46e-03 | 0.28800 | -0.22200 | 0.18400 | 3.03e-03 | 1.39e-02 |
| REACTOME PEROXISOMAL LIPID METABOLISM | 16 | 1.33e-01 | 2.94e-01 | 0.28600 | -0.14000 | -0.25000 | 3.31e-01 | 8.41e-02 |
| REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 24 | 5.10e-02 | 1.69e-01 | 0.28500 | 0.26300 | 0.11000 | 2.59e-02 | 3.53e-01 |
| REACTOME CYTOSOLIC TRNA AMINOACYLATION | 22 | 6.64e-02 | 1.95e-01 | 0.28400 | 0.12600 | 0.25400 | 3.06e-01 | 3.93e-02 |
| REACTOME CELL CYCLE CHECKPOINTS | 78 | 7.22e-05 | 1.57e-03 | 0.28300 | 0.11600 | 0.25800 | 7.65e-02 | 8.21e-05 |
| REACTOME EXTRACELLULAR MATRIX ORGANIZATION | 31 | 2.69e-02 | 1.04e-01 | 0.28300 | -0.18700 | 0.21300 | 7.21e-02 | 4.03e-02 |
| REACTOME REGULATION OF KIT SIGNALING | 10 | 3.06e-01 | 4.94e-01 | 0.28300 | -0.27300 | 0.07670 | 1.35e-01 | 6.75e-01 |
| REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 21 | 7.79e-02 | 2.10e-01 | 0.28300 | 0.27000 | 0.08480 | 3.26e-02 | 5.02e-01 |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | 11 | 2.78e-01 | 4.69e-01 | 0.28200 | -0.13300 | 0.24800 | 4.44e-01 | 1.54e-01 |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 50 | 2.24e-03 | 1.65e-02 | 0.28200 | 0.21200 | 0.18600 | 9.66e-03 | 2.33e-02 |
| REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | 24 | 5.84e-02 | 1.83e-01 | 0.28200 | -0.01600 | 0.28100 | 8.92e-01 | 1.72e-02 |
| REACTOME P75NTR SIGNALS VIA NFKB | 10 | 3.11e-01 | 4.98e-01 | 0.28100 | -0.27500 | 0.05860 | 1.33e-01 | 7.48e-01 |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 15 | 1.72e-01 | 3.51e-01 | 0.27900 | 0.03510 | 0.27700 | 8.14e-01 | 6.38e-02 |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 41 | 7.55e-03 | 4.01e-02 | 0.27900 | -0.15100 | -0.23400 | 9.45e-02 | 9.56e-03 |
| REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 23 | 7.21e-02 | 2.02e-01 | 0.27500 | 0.03140 | 0.27400 | 7.94e-01 | 2.32e-02 |
| REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | 44 | 7.72e-03 | 4.01e-02 | 0.27500 | -0.24900 | 0.11600 | 4.25e-03 | 1.84e-01 |
| REACTOME GLYCOLYSIS | 19 | 1.11e-01 | 2.59e-01 | 0.27500 | 0.12700 | 0.24400 | 3.37e-01 | 6.62e-02 |
| REACTOME GPCR LIGAND BINDING | 40 | 1.07e-02 | 5.37e-02 | 0.27500 | -0.03070 | -0.27300 | 7.37e-01 | 2.85e-03 |
| REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | 24 | 7.16e-02 | 2.02e-01 | 0.27400 | 0.23600 | -0.14000 | 4.56e-02 | 2.35e-01 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | 12 | 2.79e-01 | 4.69e-01 | 0.27000 | -0.24000 | 0.12300 | 1.50e-01 | 4.62e-01 |
| REACTOME ION TRANSPORT BY P TYPE ATPASES | 17 | 1.53e-01 | 3.24e-01 | 0.26900 | -0.07680 | -0.25800 | 5.84e-01 | 6.55e-02 |
| REACTOME MRNA SPLICING | 100 | 2.50e-05 | 6.35e-04 | 0.26800 | -0.26400 | 0.04630 | 5.23e-06 | 4.26e-01 |
| REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | 14 | 2.17e-01 | 4.09e-01 | 0.26800 | 0.25500 | 0.08240 | 9.90e-02 | 5.94e-01 |
| REACTOME METAL ION SLC TRANSPORTERS | 12 | 2.75e-01 | 4.69e-01 | 0.26700 | -0.02520 | -0.26600 | 8.80e-01 | 1.11e-01 |
| REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 17 | 1.67e-01 | 3.42e-01 | 0.26700 | -0.25700 | 0.07200 | 6.65e-02 | 6.07e-01 |
| REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | 38 | 1.70e-02 | 7.56e-02 | 0.26700 | 0.03440 | 0.26500 | 7.14e-01 | 4.82e-03 |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 48 | 5.60e-03 | 3.28e-02 | 0.26500 | 0.15100 | 0.21800 | 7.15e-02 | 8.92e-03 |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | 34 | 2.60e-02 | 1.03e-01 | 0.26500 | -0.24700 | -0.09760 | 1.29e-02 | 3.25e-01 |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | 19 | 1.32e-01 | 2.94e-01 | 0.26400 | -0.25000 | -0.08460 | 5.90e-02 | 5.23e-01 |
| REACTOME CHROMOSOME MAINTENANCE | 37 | 2.08e-02 | 8.74e-02 | 0.26400 | -0.26200 | -0.02800 | 5.83e-03 | 7.68e-01 |
| REACTOME LIPOPROTEIN METABOLISM | 11 | 3.29e-01 | 5.17e-01 | 0.26300 | -0.21000 | 0.15900 | 2.28e-01 | 3.62e-01 |
| REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | 50 | 5.92e-03 | 3.42e-02 | 0.26300 | -0.26000 | 0.04110 | 1.49e-03 | 6.16e-01 |
| REACTOME COLLAGEN FORMATION | 26 | 7.28e-02 | 2.03e-01 | 0.26300 | -0.18100 | 0.19100 | 1.11e-01 | 9.14e-02 |
| REACTOME EXTENSION OF TELOMERES | 15 | 2.24e-01 | 4.16e-01 | 0.26200 | -0.21500 | 0.15000 | 1.50e-01 | 3.16e-01 |
| REACTOME MEIOSIS | 25 | 8.17e-02 | 2.13e-01 | 0.26100 | -0.25000 | 0.07350 | 3.05e-02 | 5.25e-01 |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 15 | 2.11e-01 | 4.03e-01 | 0.26000 | -0.12800 | -0.22600 | 3.91e-01 | 1.29e-01 |
| REACTOME M G1 TRANSITION | 51 | 5.11e-03 | 3.11e-02 | 0.26000 | 0.14500 | 0.21500 | 7.30e-02 | 7.92e-03 |
| REACTOME PHOSPHORYLATION OF THE APC C | 14 | 2.45e-01 | 4.38e-01 | 0.25900 | 0.00731 | 0.25800 | 9.62e-01 | 9.41e-02 |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | 10 | 3.71e-01 | 5.53e-01 | 0.25800 | -0.25700 | 0.02540 | 1.60e-01 | 8.89e-01 |
| REACTOME SYNTHESIS OF DNA | 61 | 2.18e-03 | 1.65e-02 | 0.25700 | 0.09400 | 0.23900 | 2.05e-01 | 1.26e-03 |
| REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | 10 | 3.64e-01 | 5.49e-01 | 0.25600 | -0.15800 | -0.20200 | 3.88e-01 | 2.70e-01 |
| REACTOME G ALPHA I SIGNALLING EVENTS | 28 | 6.30e-02 | 1.90e-01 | 0.25300 | -0.19100 | -0.16600 | 8.02e-02 | 1.29e-01 |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 27 | 7.81e-02 | 2.10e-01 | 0.25100 | 0.25100 | -0.00148 | 2.40e-02 | 9.89e-01 |
| REACTOME VIRAL MESSENGER RNA SYNTHESIS | 14 | 2.70e-01 | 4.66e-01 | 0.25100 | -0.24600 | 0.04750 | 1.11e-01 | 7.58e-01 |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 16 | 2.12e-01 | 4.03e-01 | 0.25100 | -0.18100 | -0.17400 | 2.11e-01 | 2.29e-01 |
| REACTOME CD28 CO STIMULATION | 22 | 1.23e-01 | 2.79e-01 | 0.24900 | -0.19600 | -0.15200 | 1.11e-01 | 2.16e-01 |
| REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | 24 | 1.11e-01 | 2.59e-01 | 0.24800 | -0.03200 | 0.24600 | 7.86e-01 | 3.69e-02 |
| REACTOME BIOLOGICAL OXIDATIONS | 39 | 3.06e-02 | 1.14e-01 | 0.24700 | 0.10900 | -0.22200 | 2.38e-01 | 1.66e-02 |
| REACTOME ELONGATION ARREST AND RECOVERY | 24 | 1.10e-01 | 2.59e-01 | 0.24700 | -0.24400 | -0.03660 | 3.85e-02 | 7.57e-01 |
| REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | 17 | 2.23e-01 | 4.16e-01 | 0.24500 | -0.23500 | 0.06680 | 9.31e-02 | 6.34e-01 |
| REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | 12 | 3.36e-01 | 5.20e-01 | 0.24400 | -0.09500 | -0.22400 | 5.69e-01 | 1.78e-01 |
| REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 19 | 1.76e-01 | 3.56e-01 | 0.24400 | -0.19400 | -0.14700 | 1.43e-01 | 2.68e-01 |
| REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | 17 | 2.19e-01 | 4.12e-01 | 0.24300 | 0.23900 | 0.04330 | 8.81e-02 | 7.58e-01 |
| REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | 28 | 8.81e-02 | 2.24e-01 | 0.24300 | 0.23200 | -0.07260 | 3.40e-02 | 5.07e-01 |
| REACTOME G2 M CHECKPOINTS | 17 | 2.37e-01 | 4.30e-01 | 0.24100 | -0.11100 | 0.21300 | 4.27e-01 | 1.28e-01 |
| REACTOME GLOBAL GENOMIC NER GG NER | 25 | 1.21e-01 | 2.75e-01 | 0.24000 | -0.10600 | 0.21600 | 3.59e-01 | 6.20e-02 |
| REACTOME SIGNALING BY HIPPO | 15 | 2.83e-01 | 4.72e-01 | 0.24000 | -0.20200 | 0.13000 | 1.76e-01 | 3.84e-01 |
| REACTOME PLC BETA MEDIATED EVENTS | 20 | 1.75e-01 | 3.56e-01 | 0.23900 | -0.21900 | -0.09440 | 8.99e-02 | 4.65e-01 |
| REACTOME MEIOTIC SYNAPSIS | 16 | 2.50e-01 | 4.45e-01 | 0.23800 | -0.22600 | -0.07550 | 1.18e-01 | 6.01e-01 |
| REACTOME MTORC1 MEDIATED SIGNALLING | 11 | 3.86e-01 | 5.64e-01 | 0.23700 | 0.19400 | 0.13600 | 2.65e-01 | 4.36e-01 |
| REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | 12 | 3.68e-01 | 5.51e-01 | 0.23600 | -0.02120 | 0.23600 | 8.99e-01 | 1.58e-01 |
| REACTOME G ALPHA Z SIGNALLING EVENTS | 19 | 2.01e-01 | 3.92e-01 | 0.23600 | -0.23300 | -0.03740 | 7.86e-02 | 7.78e-01 |
| REACTOME NEPHRIN INTERACTIONS | 15 | 2.78e-01 | 4.69e-01 | 0.23600 | -0.21900 | -0.08930 | 1.43e-01 | 5.49e-01 |
| REACTOME PI 3K CASCADE | 34 | 5.79e-02 | 1.82e-01 | 0.23400 | -0.12800 | -0.19500 | 1.96e-01 | 4.91e-02 |
| REACTOME DOUBLE STRAND BREAK REPAIR | 12 | 3.76e-01 | 5.57e-01 | 0.23400 | -0.00836 | 0.23300 | 9.60e-01 | 1.62e-01 |
| REACTOME RECYCLING PATHWAY OF L1 | 18 | 2.38e-01 | 4.30e-01 | 0.23400 | -0.20900 | 0.10500 | 1.26e-01 | 4.41e-01 |
| REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 19 | 2.23e-01 | 4.16e-01 | 0.23300 | 0.16000 | -0.16900 | 2.27e-01 | 2.02e-01 |
| REACTOME NRAGE SIGNALS DEATH THROUGH JNK | 27 | 1.18e-01 | 2.70e-01 | 0.23200 | 0.09540 | -0.21200 | 3.92e-01 | 5.68e-02 |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | 16 | 2.84e-01 | 4.72e-01 | 0.23200 | -0.10500 | 0.20700 | 4.68e-01 | 1.52e-01 |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 126 | 5.55e-05 | 1.27e-03 | 0.23100 | -0.21700 | 0.07890 | 2.69e-05 | 1.27e-01 |
| REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | 20 | 2.09e-01 | 4.03e-01 | 0.23100 | 0.21000 | -0.09630 | 1.04e-01 | 4.56e-01 |
| REACTOME ENOS ACTIVATION AND REGULATION | 12 | 3.82e-01 | 5.59e-01 | 0.23000 | -0.04950 | -0.22500 | 7.67e-01 | 1.78e-01 |
| REACTOME HS GAG DEGRADATION | 11 | 4.21e-01 | 6.01e-01 | 0.23000 | -0.22900 | 0.01510 | 1.88e-01 | 9.31e-01 |
| REACTOME GAB1 SIGNALOSOME | 32 | 7.80e-02 | 2.10e-01 | 0.22800 | -0.16000 | -0.16200 | 1.17e-01 | 1.14e-01 |
| REACTOME G0 AND EARLY G1 | 11 | 4.22e-01 | 6.01e-01 | 0.22700 | -0.04550 | -0.22300 | 7.94e-01 | 2.01e-01 |
| REACTOME GPVI MEDIATED ACTIVATION CASCADE | 17 | 2.81e-01 | 4.71e-01 | 0.22600 | -0.20200 | 0.10200 | 1.50e-01 | 4.69e-01 |
| REACTOME FORMATION OF INCISION COMPLEX IN GG NER | 18 | 2.54e-01 | 4.51e-01 | 0.22500 | 0.01700 | 0.22400 | 9.01e-01 | 9.98e-02 |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 97 | 6.59e-04 | 7.10e-03 | 0.22500 | 0.03010 | 0.22300 | 6.10e-01 | 1.59e-04 |
| REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | 22 | 1.85e-01 | 3.69e-01 | 0.22300 | -0.11200 | -0.19300 | 3.63e-01 | 1.17e-01 |
| REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 43 | 4.39e-02 | 1.48e-01 | 0.22200 | -0.03210 | 0.21900 | 7.16e-01 | 1.30e-02 |
| REACTOME CTLA4 INHIBITORY SIGNALING | 16 | 2.98e-01 | 4.89e-01 | 0.22100 | -0.16400 | -0.14900 | 2.58e-01 | 3.01e-01 |
| REACTOME INTERFERON SIGNALING | 80 | 3.52e-03 | 2.33e-02 | 0.22000 | -0.10100 | 0.19600 | 1.20e-01 | 2.49e-03 |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 125 | 1.62e-04 | 2.75e-03 | 0.22000 | 0.14700 | -0.16400 | 4.79e-03 | 1.58e-03 |
| REACTOME SIGNALING BY WNT | 56 | 1.57e-02 | 7.10e-02 | 0.22000 | 0.16300 | 0.14800 | 3.54e-02 | 5.63e-02 |
| REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 21 | 2.31e-01 | 4.25e-01 | 0.21900 | -0.17700 | 0.13000 | 1.62e-01 | 3.04e-01 |
| REACTOME G ALPHA S SIGNALLING EVENTS | 27 | 1.42e-01 | 3.08e-01 | 0.21800 | -0.06560 | -0.20800 | 5.55e-01 | 6.16e-02 |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 106 | 5.50e-04 | 6.23e-03 | 0.21700 | 0.20700 | 0.06240 | 2.34e-04 | 2.68e-01 |
| REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | 34 | 9.82e-02 | 2.40e-01 | 0.21600 | -0.10900 | 0.18700 | 2.72e-01 | 5.95e-02 |
| REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | 16 | 3.31e-01 | 5.19e-01 | 0.21600 | 0.03740 | -0.21200 | 7.96e-01 | 1.41e-01 |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 53 | 2.28e-02 | 9.29e-02 | 0.21600 | 0.12900 | 0.17200 | 1.04e-01 | 3.01e-02 |
| REACTOME ERK MAPK TARGETS | 17 | 3.15e-01 | 5.02e-01 | 0.21400 | 0.20800 | -0.05330 | 1.38e-01 | 7.04e-01 |
| REACTOME ER PHAGOSOME PATHWAY | 48 | 3.58e-02 | 1.28e-01 | 0.21400 | 0.06310 | 0.20400 | 4.50e-01 | 1.45e-02 |
| REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | 18 | 2.88e-01 | 4.76e-01 | 0.21300 | 0.20800 | 0.04870 | 1.27e-01 | 7.21e-01 |
| REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | 37 | 8.42e-02 | 2.15e-01 | 0.21300 | -0.20400 | 0.06150 | 3.18e-02 | 5.18e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | 21 | 2.42e-01 | 4.33e-01 | 0.21300 | -0.00805 | 0.21300 | 9.49e-01 | 9.19e-02 |
| REACTOME G1 PHASE | 25 | 1.93e-01 | 3.79e-01 | 0.21300 | -0.17400 | 0.12200 | 1.32e-01 | 2.93e-01 |
| REACTOME PKB MEDIATED EVENTS | 27 | 1.58e-01 | 3.31e-01 | 0.21200 | 0.20700 | 0.04780 | 6.28e-02 | 6.68e-01 |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | 15 | 3.64e-01 | 5.49e-01 | 0.21200 | -0.21200 | 0.00912 | 1.55e-01 | 9.51e-01 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 18 | 2.98e-01 | 4.89e-01 | 0.21200 | 0.00106 | -0.21200 | 9.94e-01 | 1.20e-01 |
| REACTOME MRNA PROCESSING | 139 | 1.20e-04 | 2.19e-03 | 0.21100 | -0.20000 | 0.06890 | 5.07e-05 | 1.63e-01 |
| REACTOME REGULATION OF INSULIN SECRETION | 39 | 6.97e-02 | 2.00e-01 | 0.21100 | -0.17400 | -0.11900 | 6.05e-02 | 1.98e-01 |
| REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | 28 | 1.59e-01 | 3.31e-01 | 0.21000 | -0.02470 | 0.20900 | 8.21e-01 | 5.61e-02 |
| REACTOME TIE2 SIGNALING | 13 | 4.17e-01 | 5.98e-01 | 0.21000 | -0.06460 | -0.20000 | 6.87e-01 | 2.12e-01 |
| REACTOME TRANSCRIPTION COUPLED NER TC NER | 36 | 9.69e-02 | 2.39e-01 | 0.21000 | -0.20300 | 0.05210 | 3.51e-02 | 5.89e-01 |
| REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | 36 | 9.89e-02 | 2.40e-01 | 0.21000 | -0.18900 | 0.09080 | 4.99e-02 | 3.47e-01 |
| REACTOME HIV LIFE CYCLE | 93 | 2.73e-03 | 1.93e-02 | 0.21000 | -0.15900 | 0.13700 | 8.32e-03 | 2.29e-02 |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | 29 | 1.52e-01 | 3.24e-01 | 0.21000 | -0.04330 | 0.20500 | 6.87e-01 | 5.63e-02 |
| REACTOME DAG AND IP3 SIGNALING | 16 | 3.42e-01 | 5.22e-01 | 0.20900 | -0.19000 | -0.08780 | 1.88e-01 | 5.43e-01 |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 38 | 8.16e-02 | 2.13e-01 | 0.20900 | -0.20300 | -0.04880 | 3.07e-02 | 6.03e-01 |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 109 | 8.38e-04 | 8.01e-03 | 0.20700 | -0.19300 | -0.07580 | 5.26e-04 | 1.73e-01 |
| REACTOME DNA REPAIR | 66 | 1.65e-02 | 7.40e-02 | 0.20700 | -0.16900 | 0.12000 | 1.78e-02 | 9.38e-02 |
| REACTOME METABOLISM OF NON CODING RNA | 40 | 8.27e-02 | 2.13e-01 | 0.20500 | -0.02440 | 0.20300 | 7.90e-01 | 2.62e-02 |
| REACTOME RNA POL II TRANSCRIPTION | 85 | 5.29e-03 | 3.17e-02 | 0.20500 | -0.20000 | 0.04390 | 1.47e-03 | 4.85e-01 |
| REACTOME G1 S TRANSITION | 67 | 1.36e-02 | 6.34e-02 | 0.20500 | 0.11000 | 0.17300 | 1.20e-01 | 1.47e-02 |
| REACTOME MRNA 3 END PROCESSING | 31 | 1.50e-01 | 3.21e-01 | 0.20400 | -0.18800 | 0.08110 | 7.07e-02 | 4.35e-01 |
| REACTOME RNA POL III CHAIN ELONGATION | 16 | 3.59e-01 | 5.46e-01 | 0.20400 | 0.08900 | 0.18400 | 5.38e-01 | 2.03e-01 |
| REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | 48 | 5.53e-02 | 1.80e-01 | 0.20400 | -0.12400 | 0.16200 | 1.38e-01 | 5.29e-02 |
| REACTOME NETRIN1 SIGNALING | 21 | 2.65e-01 | 4.59e-01 | 0.20400 | -0.19100 | -0.06930 | 1.29e-01 | 5.83e-01 |
| REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 21 | 2.65e-01 | 4.59e-01 | 0.20300 | -0.18600 | -0.08270 | 1.41e-01 | 5.12e-01 |
| REACTOME S PHASE | 71 | 1.16e-02 | 5.75e-02 | 0.20300 | 0.08390 | 0.18500 | 2.23e-01 | 7.16e-03 |
| REACTOME INWARDLY RECTIFYING K CHANNELS | 10 | 5.48e-01 | 7.07e-01 | 0.20300 | 0.11000 | -0.17100 | 5.47e-01 | 3.50e-01 |
| REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 13 | 4.56e-01 | 6.36e-01 | 0.20300 | -0.18300 | 0.08720 | 2.53e-01 | 5.86e-01 |
| REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | 15 | 3.97e-01 | 5.74e-01 | 0.20100 | -0.04550 | -0.19600 | 7.61e-01 | 1.88e-01 |
| REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | 15 | 3.95e-01 | 5.73e-01 | 0.20100 | -0.17700 | -0.09430 | 2.34e-01 | 5.27e-01 |
| REACTOME ASPARAGINE N LINKED GLYCOSYLATION | 62 | 2.70e-02 | 1.04e-01 | 0.20100 | -0.14900 | 0.13500 | 4.33e-02 | 6.73e-02 |
| REACTOME REGULATORY RNA PATHWAYS | 21 | 2.85e-01 | 4.72e-01 | 0.19900 | -0.19900 | -0.01660 | 1.16e-01 | 8.95e-01 |
| REACTOME RNA POL I TRANSCRIPTION TERMINATION | 19 | 3.34e-01 | 5.20e-01 | 0.19900 | -0.09510 | 0.17500 | 4.73e-01 | 1.88e-01 |
| REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | 14 | 4.41e-01 | 6.23e-01 | 0.19900 | -0.19500 | 0.03990 | 2.08e-01 | 7.96e-01 |
| REACTOME NUCLEOTIDE EXCISION REPAIR | 40 | 1.01e-01 | 2.42e-01 | 0.19800 | -0.17600 | 0.09110 | 5.45e-02 | 3.19e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | 11 | 5.31e-01 | 6.99e-01 | 0.19600 | -0.19600 | -0.00607 | 2.61e-01 | 9.72e-01 |
| REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | 10 | 5.63e-01 | 7.11e-01 | 0.19500 | 0.04230 | 0.19000 | 8.17e-01 | 2.98e-01 |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 47 | 6.49e-02 | 1.93e-01 | 0.19500 | -0.13700 | -0.13900 | 1.06e-01 | 1.01e-01 |
| REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | 37 | 1.18e-01 | 2.70e-01 | 0.19400 | -0.08390 | -0.17500 | 3.78e-01 | 6.51e-02 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 13 | 4.70e-01 | 6.47e-01 | 0.19400 | -0.10600 | -0.16300 | 5.08e-01 | 3.10e-01 |
| REACTOME METABOLISM OF MRNA | 176 | 7.97e-05 | 1.66e-03 | 0.19300 | -0.16300 | 0.10400 | 2.14e-04 | 1.74e-02 |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 25 | 2.39e-01 | 4.30e-01 | 0.19300 | -0.12400 | -0.14800 | 2.84e-01 | 2.01e-01 |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 49 | 6.64e-02 | 1.95e-01 | 0.19300 | -0.19300 | 0.00229 | 1.99e-02 | 9.78e-01 |
| REACTOME METABOLISM OF RNA | 213 | 1.30e-05 | 3.72e-04 | 0.19200 | -0.14300 | 0.12900 | 3.56e-04 | 1.27e-03 |
| REACTOME SIGNALING BY BMP | 17 | 4.03e-01 | 5.81e-01 | 0.19100 | 0.09760 | -0.16500 | 4.86e-01 | 2.40e-01 |
| REACTOME SPHINGOLIPID METABOLISM | 35 | 1.52e-01 | 3.24e-01 | 0.18900 | -0.18800 | -0.01990 | 5.42e-02 | 8.39e-01 |
| REACTOME BASIGIN INTERACTIONS | 14 | 4.66e-01 | 6.45e-01 | 0.18900 | 0.17100 | 0.08090 | 2.69e-01 | 6.00e-01 |
| REACTOME GPCR DOWNSTREAM SIGNALING | 104 | 3.70e-03 | 2.42e-02 | 0.18800 | -0.08780 | -0.16600 | 1.23e-01 | 3.47e-03 |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 85 | 1.33e-02 | 6.24e-02 | 0.18800 | -0.13100 | 0.13500 | 3.77e-02 | 3.24e-02 |
| REACTOME CA DEPENDENT EVENTS | 14 | 4.68e-01 | 6.47e-01 | 0.18800 | -0.15300 | -0.10900 | 3.23e-01 | 4.81e-01 |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 31 | 2.13e-01 | 4.03e-01 | 0.18400 | 0.17800 | -0.04570 | 8.62e-02 | 6.60e-01 |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 56 | 6.31e-02 | 1.90e-01 | 0.18100 | 0.04000 | 0.17600 | 6.05e-01 | 2.28e-02 |
| REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 20 | 3.67e-01 | 5.51e-01 | 0.18000 | -0.12300 | -0.13200 | 3.43e-01 | 3.06e-01 |
| REACTOME METABOLISM OF PORPHYRINS | 11 | 5.89e-01 | 7.23e-01 | 0.18000 | 0.17900 | -0.02210 | 3.05e-01 | 8.99e-01 |
| REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | 28 | 2.59e-01 | 4.56e-01 | 0.17900 | -0.17900 | -0.00257 | 1.01e-01 | 9.81e-01 |
| REACTOME RNA POL I TRANSCRIPTION INITIATION | 23 | 3.37e-01 | 5.20e-01 | 0.17900 | -0.03870 | 0.17500 | 7.48e-01 | 1.47e-01 |
| REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | 27 | 2.74e-01 | 4.69e-01 | 0.17900 | -0.17800 | -0.01900 | 1.11e-01 | 8.65e-01 |
| REACTOME SOS MEDIATED SIGNALLING | 13 | 5.44e-01 | 7.07e-01 | 0.17800 | -0.03920 | 0.17300 | 8.07e-01 | 2.79e-01 |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 164 | 3.82e-04 | 5.13e-03 | 0.17800 | 0.13400 | 0.11700 | 3.18e-03 | 1.03e-02 |
| REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | 17 | 4.46e-01 | 6.27e-01 | 0.17800 | -0.17600 | -0.01920 | 2.08e-01 | 8.91e-01 |
| REACTOME GABA RECEPTOR ACTIVATION | 15 | 4.84e-01 | 6.59e-01 | 0.17700 | -0.15200 | -0.09060 | 3.07e-01 | 5.44e-01 |
| REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | 17 | 4.61e-01 | 6.41e-01 | 0.17600 | -0.16200 | 0.06940 | 2.48e-01 | 6.21e-01 |
| REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | 13 | 5.55e-01 | 7.11e-01 | 0.17600 | -0.08450 | 0.15400 | 5.98e-01 | 3.35e-01 |
| REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 51 | 9.42e-02 | 2.35e-01 | 0.17500 | 0.03500 | 0.17200 | 6.66e-01 | 3.43e-02 |
| REACTOME REGULATION OF SIGNALING BY CBL | 14 | 5.21e-01 | 6.98e-01 | 0.17400 | -0.15600 | -0.07840 | 3.13e-01 | 6.12e-01 |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 11 | 6.14e-01 | 7.44e-01 | 0.17400 | 0.09230 | -0.14800 | 5.96e-01 | 3.96e-01 |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 58 | 6.80e-02 | 1.97e-01 | 0.17400 | -0.08860 | -0.15000 | 2.44e-01 | 4.88e-02 |
| REACTOME TRANSCRIPTION | 126 | 4.33e-03 | 2.75e-02 | 0.17300 | -0.15600 | 0.07380 | 2.56e-03 | 1.54e-01 |
| REACTOME CIRCADIAN CLOCK | 42 | 1.59e-01 | 3.31e-01 | 0.17300 | 0.16400 | -0.05450 | 6.66e-02 | 5.41e-01 |
| REACTOME MITOTIC G2 G2 M PHASES | 49 | 1.17e-01 | 2.70e-01 | 0.17200 | -0.03870 | 0.16800 | 6.40e-01 | 4.23e-02 |
| REACTOME GABA B RECEPTOR ACTIVATION | 14 | 5.32e-01 | 6.99e-01 | 0.17200 | -0.16600 | -0.04580 | 2.83e-01 | 7.67e-01 |
| REACTOME DNA REPLICATION | 110 | 7.65e-03 | 4.01e-02 | 0.17200 | 0.03830 | 0.16700 | 4.89e-01 | 2.50e-03 |
| REACTOME RNA POL I TRANSCRIPTION | 26 | 3.29e-01 | 5.17e-01 | 0.17100 | -0.11000 | 0.13200 | 3.33e-01 | 2.45e-01 |
| REACTOME MITOTIC M M G1 PHASES | 98 | 1.27e-02 | 6.07e-02 | 0.17100 | 0.06560 | 0.15800 | 2.63e-01 | 6.94e-03 |
| REACTOME P38MAPK EVENTS | 10 | 6.51e-01 | 7.73e-01 | 0.17100 | 0.08360 | -0.15000 | 6.47e-01 | 4.13e-01 |
| REACTOME PI3K EVENTS IN ERBB2 SIGNALING | 32 | 2.37e-01 | 4.30e-01 | 0.17100 | -0.10900 | -0.13200 | 2.86e-01 | 1.98e-01 |
| REACTOME SULFUR AMINO ACID METABOLISM | 18 | 4.50e-01 | 6.29e-01 | 0.17000 | 0.14900 | 0.08110 | 2.72e-01 | 5.52e-01 |
| REACTOME KERATAN SULFATE KERATIN METABOLISM | 14 | 5.36e-01 | 7.00e-01 | 0.17000 | -0.12500 | -0.11500 | 4.19e-01 | 4.55e-01 |
| REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | 15 | 5.30e-01 | 6.99e-01 | 0.16900 | 0.16200 | -0.05030 | 2.78e-01 | 7.36e-01 |
| REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | 13 | 5.66e-01 | 7.11e-01 | 0.16900 | -0.14500 | -0.08710 | 3.67e-01 | 5.87e-01 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 13 | 5.76e-01 | 7.19e-01 | 0.16700 | -0.15100 | -0.07030 | 3.46e-01 | 6.61e-01 |
| REACTOME SIGNALING BY FGFR MUTANTS | 27 | 3.40e-01 | 5.22e-01 | 0.16400 | -0.16300 | 0.00625 | 1.42e-01 | 9.55e-01 |
| REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION | 99 | 2.23e-02 | 9.19e-02 | 0.16300 | -0.12100 | 0.11000 | 3.81e-02 | 6.04e-02 |
| REACTOME SIGNALING BY FGFR1 MUTANTS | 21 | 4.35e-01 | 6.15e-01 | 0.16300 | -0.16200 | -0.00507 | 1.98e-01 | 9.68e-01 |
| REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 25 | 3.73e-01 | 5.55e-01 | 0.16200 | -0.16200 | -0.01300 | 1.62e-01 | 9.10e-01 |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 62 | 8.27e-02 | 2.13e-01 | 0.16200 | -0.13200 | -0.09410 | 7.31e-02 | 2.01e-01 |
| REACTOME MEMBRANE TRAFFICKING | 93 | 2.75e-02 | 1.06e-01 | 0.16200 | -0.16000 | 0.02630 | 7.91e-03 | 6.62e-01 |
| REACTOME APOPTOTIC EXECUTION PHASE | 27 | 3.43e-01 | 5.22e-01 | 0.16100 | -0.15100 | -0.05670 | 1.75e-01 | 6.10e-01 |
| REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 60 | 9.26e-02 | 2.33e-01 | 0.16100 | -0.13000 | -0.09470 | 8.21e-02 | 2.06e-01 |
| REACTOME CELL CYCLE MITOTIC | 191 | 7.60e-04 | 7.55e-03 | 0.16000 | -0.01490 | 0.16000 | 7.24e-01 | 1.55e-04 |
| REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX | 35 | 2.63e-01 | 4.59e-01 | 0.16000 | -0.16000 | 0.00128 | 1.02e-01 | 9.90e-01 |
| REACTOME CTNNB1 PHOSPHORYLATION CASCADE | 14 | 5.83e-01 | 7.23e-01 | 0.16000 | -0.02750 | -0.15700 | 8.59e-01 | 3.08e-01 |
| REACTOME METABOLISM OF PROTEINS | 301 | 1.97e-05 | 5.30e-04 | 0.16000 | -0.12400 | 0.10000 | 2.42e-04 | 3.02e-03 |
| REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | 20 | 4.75e-01 | 6.51e-01 | 0.16000 | -0.08000 | 0.13800 | 5.36e-01 | 2.85e-01 |
| REACTOME HIV INFECTION | 155 | 3.32e-03 | 2.23e-02 | 0.16000 | -0.05910 | 0.14800 | 2.06e-01 | 1.53e-03 |
| REACTOME MICRORNA MIRNA BIOGENESIS | 18 | 5.15e-01 | 6.92e-01 | 0.15800 | -0.14900 | 0.05460 | 2.75e-01 | 6.89e-01 |
| REACTOME PI3K EVENTS IN ERBB4 SIGNALING | 28 | 3.42e-01 | 5.22e-01 | 0.15800 | -0.07250 | -0.14100 | 5.07e-01 | 1.98e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | 14 | 6.05e-01 | 7.35e-01 | 0.15700 | -0.12200 | 0.09860 | 4.29e-01 | 5.23e-01 |
| REACTOME PIP3 ACTIVATES AKT SIGNALING | 25 | 3.91e-01 | 5.69e-01 | 0.15700 | -0.06500 | -0.14300 | 5.74e-01 | 2.17e-01 |
| REACTOME NOD1 2 SIGNALING PATHWAY | 18 | 5.09e-01 | 6.88e-01 | 0.15700 | -0.14100 | -0.06780 | 3.00e-01 | 6.19e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | 25 | 4.05e-01 | 5.82e-01 | 0.15600 | -0.02330 | 0.15400 | 8.40e-01 | 1.82e-01 |
| REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | 17 | 5.45e-01 | 7.07e-01 | 0.15500 | -0.03100 | 0.15200 | 8.25e-01 | 2.78e-01 |
| REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 21 | 4.82e-01 | 6.58e-01 | 0.15400 | 0.07700 | -0.13400 | 5.41e-01 | 2.89e-01 |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 146 | 6.89e-03 | 3.84e-02 | 0.15400 | -0.09640 | 0.12000 | 4.53e-02 | 1.26e-02 |
| REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | 14 | 6.15e-01 | 7.44e-01 | 0.15300 | -0.02200 | 0.15100 | 8.87e-01 | 3.27e-01 |
| REACTOME SEMA4D IN SEMAPHORIN SIGNALING | 22 | 4.72e-01 | 6.48e-01 | 0.15200 | -0.14100 | 0.05770 | 2.52e-01 | 6.40e-01 |
| REACTOME UNFOLDED PROTEIN RESPONSE | 62 | 1.13e-01 | 2.65e-01 | 0.15200 | -0.07370 | -0.13200 | 3.17e-01 | 7.18e-02 |
| REACTOME G ALPHA1213 SIGNALLING EVENTS | 42 | 2.37e-01 | 4.30e-01 | 0.15000 | -0.06470 | -0.13500 | 4.69e-01 | 1.30e-01 |
| REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 17 | 5.73e-01 | 7.17e-01 | 0.14900 | 0.13900 | -0.05410 | 3.21e-01 | 7.00e-01 |
| REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA | 18 | 5.58e-01 | 7.11e-01 | 0.14900 | -0.12600 | 0.07930 | 3.54e-01 | 5.61e-01 |
| REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 47 | 2.03e-01 | 3.94e-01 | 0.14900 | -0.13400 | -0.06580 | 1.14e-01 | 4.36e-01 |
| REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | 14 | 6.31e-01 | 7.57e-01 | 0.14800 | -0.00107 | -0.14800 | 9.94e-01 | 3.37e-01 |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 17 | 5.65e-01 | 7.11e-01 | 0.14800 | -0.06990 | -0.13000 | 6.18e-01 | 3.52e-01 |
| REACTOME ACTIVATION OF GENES BY ATF4 | 18 | 5.47e-01 | 7.07e-01 | 0.14800 | -0.09740 | -0.11100 | 4.74e-01 | 4.16e-01 |
| REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | 16 | 6.03e-01 | 7.35e-01 | 0.14600 | -0.02660 | 0.14300 | 8.54e-01 | 3.21e-01 |
| REACTOME CELL CYCLE | 218 | 1.24e-03 | 1.09e-02 | 0.14600 | -0.04140 | 0.14000 | 2.96e-01 | 4.07e-04 |
| REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 10 | 7.32e-01 | 8.35e-01 | 0.14500 | -0.14000 | 0.03820 | 4.43e-01 | 8.35e-01 |
| REACTOME RNA POL III TRANSCRIPTION | 31 | 3.81e-01 | 5.59e-01 | 0.14500 | -0.04120 | 0.13900 | 6.92e-01 | 1.80e-01 |
| REACTOME SEMAPHORIN INTERACTIONS | 42 | 2.74e-01 | 4.69e-01 | 0.14500 | -0.12800 | 0.06890 | 1.52e-01 | 4.40e-01 |
| REACTOME SHC1 EVENTS IN EGFR SIGNALING | 14 | 6.50e-01 | 7.73e-01 | 0.14500 | -0.11000 | 0.09510 | 4.77e-01 | 5.38e-01 |
| REACTOME PI METABOLISM | 37 | 3.02e-01 | 4.92e-01 | 0.14500 | -0.08890 | -0.11500 | 3.50e-01 | 2.28e-01 |
| REACTOME INSULIN SYNTHESIS AND PROCESSING | 13 | 6.57e-01 | 7.77e-01 | 0.14500 | -0.10300 | -0.10200 | 5.20e-01 | 5.26e-01 |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 95 | 5.54e-02 | 1.80e-01 | 0.14300 | 0.14300 | -0.00748 | 1.62e-02 | 9.00e-01 |
| REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | 56 | 1.90e-01 | 3.74e-01 | 0.14300 | -0.07960 | 0.11900 | 3.03e-01 | 1.25e-01 |
| REACTOME PROTEIN FOLDING | 40 | 3.04e-01 | 4.92e-01 | 0.14100 | -0.00341 | 0.14100 | 9.70e-01 | 1.23e-01 |
| REACTOME DEADENYLATION OF MRNA | 16 | 6.27e-01 | 7.54e-01 | 0.14100 | 0.05910 | -0.12800 | 6.83e-01 | 3.75e-01 |
| REACTOME OPIOID SIGNALLING | 39 | 3.04e-01 | 4.92e-01 | 0.14100 | -0.11500 | -0.08170 | 2.15e-01 | 3.78e-01 |
| REACTOME RNA POL III TRANSCRIPTION TERMINATION | 18 | 5.80e-01 | 7.22e-01 | 0.14000 | 0.09920 | 0.09890 | 4.66e-01 | 4.68e-01 |
| REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | 18 | 5.87e-01 | 7.23e-01 | 0.14000 | -0.14000 | -0.01180 | 3.05e-01 | 9.31e-01 |
| REACTOME MAP KINASE ACTIVATION IN TLR CASCADE | 40 | 3.21e-01 | 5.09e-01 | 0.14000 | 0.11900 | -0.07270 | 1.92e-01 | 4.27e-01 |
| REACTOME PHOSPHOLIPID METABOLISM | 113 | 3.65e-02 | 1.28e-01 | 0.14000 | -0.03490 | -0.13500 | 5.24e-01 | 1.34e-02 |
| REACTOME SIGNALING BY FGFR | 69 | 1.29e-01 | 2.91e-01 | 0.13900 | -0.11700 | -0.07500 | 9.24e-02 | 2.83e-01 |
| REACTOME SIGNAL ATTENUATION | 10 | 7.53e-01 | 8.46e-01 | 0.13900 | 0.12000 | -0.07030 | 5.11e-01 | 7.00e-01 |
| REACTOME SIGNALING BY ROBO RECEPTOR | 19 | 5.85e-01 | 7.23e-01 | 0.13900 | -0.10200 | 0.09440 | 4.41e-01 | 4.76e-01 |
| REACTOME INNATE IMMUNE SYSTEM | 119 | 3.64e-02 | 1.28e-01 | 0.13800 | -0.13400 | 0.03470 | 1.21e-02 | 5.15e-01 |
| REACTOME SIGNALING BY EGFR IN CANCER | 83 | 9.82e-02 | 2.40e-01 | 0.13700 | -0.13700 | -0.00532 | 3.16e-02 | 9.33e-01 |
| REACTOME SIGNALING BY GPCR | 144 | 1.75e-02 | 7.63e-02 | 0.13600 | -0.05570 | -0.12400 | 2.51e-01 | 1.03e-02 |
| REACTOME SIGNALLING TO P38 VIA RIT AND RIN | 11 | 7.44e-01 | 8.40e-01 | 0.13400 | -0.00882 | 0.13400 | 9.60e-01 | 4.42e-01 |
| REACTOME HEMOSTASIS | 217 | 2.86e-03 | 1.98e-02 | 0.13400 | -0.10700 | -0.07990 | 6.80e-03 | 4.39e-02 |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 79 | 1.33e-01 | 2.94e-01 | 0.13300 | 0.06970 | -0.11300 | 2.85e-01 | 8.37e-02 |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 37 | 3.79e-01 | 5.59e-01 | 0.13200 | 0.13200 | 0.00404 | 1.65e-01 | 9.66e-01 |
| REACTOME MITOTIC G1 G1 S PHASES | 82 | 1.17e-01 | 2.70e-01 | 0.13200 | 0.02120 | 0.13000 | 7.40e-01 | 4.20e-02 |
| REACTOME BOTULINUM NEUROTOXICITY | 10 | 7.77e-01 | 8.52e-01 | 0.13100 | -0.12300 | 0.04560 | 5.01e-01 | 8.03e-01 |
| REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | 10 | 7.77e-01 | 8.52e-01 | 0.13100 | -0.12300 | 0.04560 | 5.01e-01 | 8.03e-01 |
| REACTOME TRIGLYCERIDE BIOSYNTHESIS | 21 | 5.84e-01 | 7.23e-01 | 0.13100 | 0.13100 | -0.00525 | 3.00e-01 | 9.67e-01 |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 25 | 5.35e-01 | 7.00e-01 | 0.13000 | -0.12400 | 0.04180 | 2.85e-01 | 7.17e-01 |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 71 | 1.62e-01 | 3.35e-01 | 0.12900 | 0.08670 | 0.09610 | 2.08e-01 | 1.63e-01 |
| REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 51 | 2.79e-01 | 4.69e-01 | 0.12900 | 0.12400 | 0.03220 | 1.25e-01 | 6.91e-01 |
| REACTOME IRON UPTAKE AND TRANSPORT | 23 | 5.59e-01 | 7.11e-01 | 0.12800 | 0.07130 | 0.10700 | 5.54e-01 | 3.76e-01 |
| REACTOME MYOGENESIS | 21 | 6.04e-01 | 7.35e-01 | 0.12800 | 0.11900 | -0.04550 | 3.44e-01 | 7.18e-01 |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 21 | 5.91e-01 | 7.24e-01 | 0.12700 | 0.09180 | 0.08850 | 4.67e-01 | 4.83e-01 |
| REACTOME SPRY REGULATION OF FGF SIGNALING | 12 | 7.44e-01 | 8.40e-01 | 0.12600 | -0.09530 | -0.08290 | 5.68e-01 | 6.19e-01 |
| REACTOME MRNA CAPPING | 28 | 5.23e-01 | 6.98e-01 | 0.12500 | -0.12300 | 0.02280 | 2.60e-01 | 8.34e-01 |
| REACTOME ERKS ARE INACTIVATED | 10 | 7.96e-01 | 8.60e-01 | 0.12400 | 0.02470 | -0.12200 | 8.92e-01 | 5.05e-01 |
| REACTOME SHC MEDIATED CASCADE | 10 | 7.91e-01 | 8.58e-01 | 0.12400 | -0.04180 | -0.11700 | 8.19e-01 | 5.23e-01 |
| REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | 11 | 7.73e-01 | 8.52e-01 | 0.12300 | -0.09750 | -0.07550 | 5.76e-01 | 6.65e-01 |
| REACTOME PERK REGULATED GENE EXPRESSION | 20 | 6.26e-01 | 7.54e-01 | 0.12300 | -0.09460 | -0.07920 | 4.64e-01 | 5.40e-01 |
| REACTOME DARPP 32 EVENTS | 17 | 6.91e-01 | 8.05e-01 | 0.12200 | 0.11100 | -0.05090 | 4.30e-01 | 7.16e-01 |
| REACTOME DIABETES PATHWAYS | 88 | 1.38e-01 | 3.02e-01 | 0.12100 | -0.10100 | -0.06810 | 1.04e-01 | 2.71e-01 |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 275 | 2.75e-03 | 1.93e-02 | 0.12100 | -0.00325 | -0.12100 | 9.27e-01 | 6.07e-04 |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 189 | 1.73e-02 | 7.61e-02 | 0.11900 | 0.06630 | 0.09910 | 1.18e-01 | 1.95e-02 |
| REACTOME CELL CELL COMMUNICATION | 52 | 3.22e-01 | 5.09e-01 | 0.11900 | -0.07200 | -0.09500 | 3.70e-01 | 2.37e-01 |
| REACTOME SHC MEDIATED SIGNALLING | 13 | 7.63e-01 | 8.51e-01 | 0.11900 | -0.05900 | 0.10400 | 7.13e-01 | 5.18e-01 |
| REACTOME AXON GUIDANCE | 140 | 6.26e-02 | 1.90e-01 | 0.11700 | -0.10400 | 0.05310 | 3.38e-02 | 2.80e-01 |
| REACTOME SIGNALING BY FGFR IN DISEASE | 82 | 1.86e-01 | 3.69e-01 | 0.11700 | -0.11400 | -0.02440 | 7.47e-02 | 7.03e-01 |
| REACTOME PRE NOTCH EXPRESSION AND PROCESSING | 31 | 5.28e-01 | 6.99e-01 | 0.11600 | -0.08760 | -0.07550 | 3.99e-01 | 4.67e-01 |
| REACTOME APOPTOSIS | 97 | 1.43e-01 | 3.10e-01 | 0.11500 | 0.03270 | 0.11000 | 5.79e-01 | 6.08e-02 |
| REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | 31 | 5.53e-01 | 7.11e-01 | 0.11400 | 0.10600 | -0.04260 | 3.08e-01 | 6.82e-01 |
| REACTOME ARMS MEDIATED ACTIVATION | 14 | 7.60e-01 | 8.49e-01 | 0.11400 | 0.01850 | 0.11200 | 9.05e-01 | 4.67e-01 |
| REACTOME METABOLISM OF CARBOHYDRATES | 128 | 8.21e-02 | 2.13e-01 | 0.11400 | 0.04490 | 0.10400 | 3.82e-01 | 4.22e-02 |
| REACTOME PROLONGED ERK ACTIVATION EVENTS | 16 | 7.42e-01 | 8.40e-01 | 0.11300 | -0.07800 | 0.08200 | 5.89e-01 | 5.70e-01 |
| REACTOME SIGNALING BY PDGF | 85 | 2.10e-01 | 4.03e-01 | 0.11300 | -0.09290 | 0.06370 | 1.40e-01 | 3.12e-01 |
| REACTOME PROCESSING OF INTRONLESS PRE MRNAS | 13 | 7.88e-01 | 8.57e-01 | 0.11200 | -0.09930 | 0.05190 | 5.36e-01 | 7.46e-01 |
| REACTOME SIGNALING BY ILS | 64 | 3.09e-01 | 4.98e-01 | 0.11200 | -0.10800 | 0.02840 | 1.36e-01 | 6.95e-01 |
| REACTOME PI3K CASCADE | 45 | 4.50e-01 | 6.29e-01 | 0.11000 | 0.10200 | -0.04070 | 2.36e-01 | 6.37e-01 |
| REACTOME ACTIVATION OF BH3 ONLY PROTEINS | 11 | 8.25e-01 | 8.79e-01 | 0.11000 | -0.06700 | 0.08690 | 7.00e-01 | 6.18e-01 |
| REACTOME DEADENYLATION DEPENDENT MRNA DECAY | 38 | 5.00e-01 | 6.78e-01 | 0.10900 | -0.06240 | -0.08940 | 5.06e-01 | 3.41e-01 |
| REACTOME SIGNALING BY SCF KIT | 57 | 3.77e-01 | 5.58e-01 | 0.10600 | -0.10300 | -0.02540 | 1.78e-01 | 7.41e-01 |
| REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | 12 | 8.12e-01 | 8.73e-01 | 0.10600 | -0.04620 | -0.09580 | 7.82e-01 | 5.66e-01 |
| REACTOME IL RECEPTOR SHC SIGNALING | 15 | 7.72e-01 | 8.52e-01 | 0.10600 | -0.08980 | -0.05610 | 5.47e-01 | 7.07e-01 |
| REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 71 | 3.15e-01 | 5.02e-01 | 0.10400 | -0.09550 | -0.04000 | 1.65e-01 | 5.61e-01 |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 81 | 2.65e-01 | 4.59e-01 | 0.10300 | 0.07190 | 0.07430 | 2.64e-01 | 2.49e-01 |
| REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | 22 | 7.06e-01 | 8.17e-01 | 0.10300 | 0.00603 | -0.10300 | 9.61e-01 | 4.04e-01 |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 55 | 4.32e-01 | 6.14e-01 | 0.10200 | -0.09580 | 0.03500 | 2.20e-01 | 6.54e-01 |
| REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | 16 | 7.85e-01 | 8.56e-01 | 0.10200 | 0.09350 | -0.03980 | 5.17e-01 | 7.83e-01 |
| REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | 16 | 7.85e-01 | 8.56e-01 | 0.10200 | 0.09350 | -0.03980 | 5.17e-01 | 7.83e-01 |
| REACTOME SIGNALLING TO ERKS | 28 | 6.62e-01 | 7.82e-01 | 0.09860 | -0.02310 | -0.09590 | 8.33e-01 | 3.80e-01 |
| REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | 13 | 8.30e-01 | 8.79e-01 | 0.09700 | 0.09300 | 0.02750 | 5.62e-01 | 8.64e-01 |
| REACTOME MITOTIC PROMETAPHASE | 46 | 5.32e-01 | 6.99e-01 | 0.09660 | -0.02790 | 0.09250 | 7.44e-01 | 2.78e-01 |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 45 | 5.30e-01 | 6.99e-01 | 0.09590 | -0.08160 | -0.05040 | 3.44e-01 | 5.59e-01 |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 172 | 1.05e-01 | 2.50e-01 | 0.09570 | 0.05860 | -0.07560 | 1.87e-01 | 8.88e-02 |
| REACTOME IMMUNE SYSTEM | 514 | 1.73e-03 | 1.41e-02 | 0.09480 | -0.06120 | 0.07240 | 1.96e-02 | 5.75e-03 |
| REACTOME IL 2 SIGNALING | 25 | 7.33e-01 | 8.35e-01 | 0.09220 | -0.08190 | 0.04220 | 4.79e-01 | 7.15e-01 |
| REACTOME HS GAG BIOSYNTHESIS | 15 | 8.30e-01 | 8.79e-01 | 0.09180 | 0.03290 | -0.08570 | 8.25e-01 | 5.66e-01 |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 14 | 8.38e-01 | 8.83e-01 | 0.09110 | 0.08770 | 0.02440 | 5.70e-01 | 8.74e-01 |
| REACTOME PI3K AKT ACTIVATION | 31 | 6.91e-01 | 8.05e-01 | 0.08870 | -0.02470 | -0.08510 | 8.12e-01 | 4.12e-01 |
| REACTOME IL1 SIGNALING | 25 | 7.77e-01 | 8.52e-01 | 0.08320 | -0.07000 | 0.04490 | 5.45e-01 | 6.98e-01 |
| REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | 13 | 8.75e-01 | 9.04e-01 | 0.08180 | -0.04420 | -0.06880 | 7.83e-01 | 6.68e-01 |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 337 | 4.51e-02 | 1.52e-01 | 0.08090 | -0.05460 | 0.05970 | 8.86e-02 | 6.23e-02 |
| REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 59 | 5.64e-01 | 7.11e-01 | 0.08080 | 0.08070 | -0.00309 | 2.84e-01 | 9.67e-01 |
| REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | 20 | 8.24e-01 | 8.79e-01 | 0.08070 | -0.01270 | 0.07970 | 9.22e-01 | 5.38e-01 |
| REACTOME SHC RELATED EVENTS | 14 | 8.73e-01 | 9.04e-01 | 0.08000 | 0.01520 | 0.07860 | 9.22e-01 | 6.11e-01 |
| REACTOME CELL JUNCTION ORGANIZATION | 28 | 7.67e-01 | 8.51e-01 | 0.07990 | 0.01250 | -0.07890 | 9.09e-01 | 4.70e-01 |
| REACTOME FATTY ACYL COA BIOSYNTHESIS | 11 | 9.02e-01 | 9.28e-01 | 0.07900 | 0.00955 | 0.07840 | 9.56e-01 | 6.53e-01 |
| REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | 39 | 7.05e-01 | 8.17e-01 | 0.07850 | 0.06420 | -0.04520 | 4.88e-01 | 6.25e-01 |
| REACTOME SIGNALING BY NOTCH | 72 | 5.15e-01 | 6.92e-01 | 0.07820 | -0.07630 | -0.01720 | 2.64e-01 | 8.01e-01 |
| REACTOME FRS2 MEDIATED CASCADE | 16 | 8.69e-01 | 9.04e-01 | 0.07610 | -0.07380 | -0.01870 | 6.10e-01 | 8.97e-01 |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 55 | 6.40e-01 | 7.66e-01 | 0.07480 | 0.04120 | -0.06240 | 5.97e-01 | 4.25e-01 |
| REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | 22 | 8.35e-01 | 8.81e-01 | 0.07470 | -0.02910 | 0.06880 | 8.14e-01 | 5.76e-01 |
| REACTOME SIGNALING BY ERBB2 | 68 | 5.64e-01 | 7.11e-01 | 0.07420 | -0.05980 | -0.04390 | 3.95e-01 | 5.32e-01 |
| REACTOME SIGNALING BY NOTCH1 | 48 | 6.87e-01 | 8.05e-01 | 0.07300 | -0.06910 | 0.02370 | 4.08e-01 | 7.77e-01 |
| REACTOME GROWTH HORMONE RECEPTOR SIGNALING | 16 | 8.89e-01 | 9.17e-01 | 0.07120 | -0.05620 | 0.04370 | 6.97e-01 | 7.62e-01 |
| REACTOME SIGNALLING TO RAS | 20 | 8.60e-01 | 8.98e-01 | 0.07060 | -0.01080 | -0.06980 | 9.33e-01 | 5.89e-01 |
| REACTOME L1CAM INTERACTIONS | 50 | 6.84e-01 | 8.04e-01 | 0.07030 | -0.05560 | -0.04310 | 4.97e-01 | 5.98e-01 |
| REACTOME PURINE METABOLISM | 26 | 8.30e-01 | 8.79e-01 | 0.06840 | -0.03210 | -0.06040 | 7.77e-01 | 5.94e-01 |
| REACTOME METABOLISM OF NUCLEOTIDES | 48 | 7.23e-01 | 8.32e-01 | 0.06780 | -0.06570 | 0.01670 | 4.32e-01 | 8.42e-01 |
| REACTOME SIGNAL TRANSDUCTION BY L1 | 27 | 8.29e-01 | 8.79e-01 | 0.06760 | -0.06500 | -0.01850 | 5.59e-01 | 8.68e-01 |
| REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 42 | 7.55e-01 | 8.46e-01 | 0.06640 | -0.01530 | -0.06460 | 8.64e-01 | 4.69e-01 |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 56 | 7.05e-01 | 8.17e-01 | 0.06550 | 0.03710 | -0.05400 | 6.32e-01 | 4.85e-01 |
| REACTOME PYRIMIDINE METABOLISM | 10 | 9.42e-01 | 9.64e-01 | 0.06350 | 0.06310 | -0.00681 | 7.30e-01 | 9.70e-01 |
| REACTOME TOLL RECEPTOR CASCADES | 72 | 6.47e-01 | 7.72e-01 | 0.06330 | -0.06180 | -0.01370 | 3.65e-01 | 8.41e-01 |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 50 | 7.48e-01 | 8.42e-01 | 0.06330 | 0.03840 | -0.05030 | 6.39e-01 | 5.39e-01 |
| REACTOME O LINKED GLYCOSYLATION OF MUCINS | 11 | 9.37e-01 | 9.62e-01 | 0.06260 | 0.00485 | 0.06240 | 9.78e-01 | 7.20e-01 |
| REACTOME SIGNALING BY INSULIN RECEPTOR | 73 | 6.72e-01 | 7.91e-01 | 0.06060 | 0.06040 | -0.00470 | 3.73e-01 | 9.45e-01 |
| REACTOME ACTIVATED TLR4 SIGNALLING | 60 | 7.39e-01 | 8.40e-01 | 0.05880 | 0.02550 | -0.05290 | 7.33e-01 | 4.79e-01 |
| REACTOME SIGNALING BY RHO GTPASES | 62 | 7.29e-01 | 8.35e-01 | 0.05770 | -0.03670 | -0.04460 | 6.18e-01 | 5.45e-01 |
| REACTOME KERATAN SULFATE BIOSYNTHESIS | 11 | 9.46e-01 | 9.65e-01 | 0.05750 | -0.05150 | -0.02550 | 7.67e-01 | 8.83e-01 |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 63 | 7.30e-01 | 8.35e-01 | 0.05710 | -0.03140 | -0.04770 | 6.67e-01 | 5.13e-01 |
| REACTOME DEVELOPMENTAL BIOLOGY | 238 | 3.37e-01 | 5.20e-01 | 0.05630 | -0.05460 | 0.01380 | 1.50e-01 | 7.16e-01 |
| REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | 10 | 9.55e-01 | 9.66e-01 | 0.05590 | 0.02900 | -0.04780 | 8.74e-01 | 7.94e-01 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 133 | 5.60e-01 | 7.11e-01 | 0.05480 | 0.05060 | -0.02120 | 3.16e-01 | 6.75e-01 |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 61 | 7.66e-01 | 8.51e-01 | 0.05380 | -0.05280 | -0.01060 | 4.77e-01 | 8.87e-01 |
| REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | 11 | 9.53e-01 | 9.66e-01 | 0.05360 | -0.05340 | -0.00500 | 7.59e-01 | 9.77e-01 |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 50 | 8.15e-01 | 8.74e-01 | 0.05310 | -0.03190 | 0.04250 | 6.96e-01 | 6.04e-01 |
| REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 33 | 8.73e-01 | 9.04e-01 | 0.05220 | 0.00755 | 0.05160 | 9.40e-01 | 6.08e-01 |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 54 | 8.03e-01 | 8.66e-01 | 0.05170 | -0.04970 | -0.01420 | 5.28e-01 | 8.57e-01 |
| REACTOME NEURONAL SYSTEM | 87 | 7.15e-01 | 8.25e-01 | 0.05170 | 0.03390 | -0.03900 | 5.86e-01 | 5.31e-01 |
| REACTOME INSULIN RECEPTOR RECYCLING | 15 | 9.48e-01 | 9.65e-01 | 0.04950 | 0.04150 | -0.02710 | 7.81e-01 | 8.56e-01 |
| REACTOME SIGNALING BY ERBB4 | 66 | 7.93e-01 | 8.59e-01 | 0.04790 | -0.03090 | -0.03660 | 6.65e-01 | 6.08e-01 |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 14 | 9.55e-01 | 9.66e-01 | 0.04600 | -0.03750 | -0.02670 | 8.08e-01 | 8.63e-01 |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 52 | 8.57e-01 | 8.96e-01 | 0.04520 | 0.03870 | -0.02330 | 6.30e-01 | 7.72e-01 |
| REACTOME PRE NOTCH PROCESSING IN GOLGI | 14 | 9.74e-01 | 9.82e-01 | 0.03540 | 0.03450 | 0.00787 | 8.23e-01 | 9.59e-01 |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 100 | 8.50e-01 | 8.91e-01 | 0.03260 | -0.02370 | -0.02250 | 6.84e-01 | 6.99e-01 |
| REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 17 | 9.78e-01 | 9.85e-01 | 0.02920 | 0.02590 | 0.01340 | 8.53e-01 | 9.24e-01 |
| REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | 10 | 9.88e-01 | 9.93e-01 | 0.02830 | 0.00688 | -0.02750 | 9.70e-01 | 8.81e-01 |
| REACTOME SIGNALLING BY NGF | 154 | 8.50e-01 | 8.91e-01 | 0.02650 | -0.02470 | -0.00964 | 5.99e-01 | 8.37e-01 |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 97 | 9.43e-01 | 9.64e-01 | 0.02030 | -0.00617 | 0.01940 | 9.17e-01 | 7.42e-01 |
| REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | 17 | 9.95e-01 | 9.98e-01 | 0.01310 | 0.00885 | 0.00971 | 9.50e-01 | 9.45e-01 |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 21 | 1.00e+00 | 1.00e+00 | 0.00219 | 0.00134 | 0.00174 | 9.92e-01 | 9.89e-01 |
Detailed Gene set reports
REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 1.93e-06 |
| p.adjustMANOVA | 6.79e-05 |
| s.dist | 0.833 |
| s.Sed | 0.521 |
| s.Ex | -0.65 |
| p.Sed | 0.00115 |
| p.Ex | 4.94e-05 |
| Gene | Sed | Ex |
|---|---|---|
| Eci1 | 4391 | -4349 |
| Acadl | 3928 | -4342 |
| Acadvl | 3969 | -4156 |
| Decr1 | 4329 | -3636 |
| Mcee | 4112 | -3534 |
| Hadha | 3079 | -3980 |
| Acadm | 4378 | -2703 |
| Hadh | 4327 | -2501 |
| Echs1 | 1811 | -4405 |
| Hadhb | 952 | -4160 |
| Pccb | 411 | -698 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Acadl | 3928 | -4342 |
| Acadm | 4378 | -2703 |
| Acads | -1886 | 2063 |
| Acadvl | 3969 | -4156 |
| Decr1 | 4329 | -3636 |
| Echs1 | 1811 | -4405 |
| Eci1 | 4391 | -4349 |
| Hadh | 4327 | -2501 |
| Hadha | 3079 | -3980 |
| Hadhb | 952 | -4160 |
| Mcee | 4112 | -3534 |
| Pcca | -8 | -2725 |
| Pccb | 411 | -698 |
REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 5.89e-06 |
| p.adjustMANOVA | 0.00018 |
| s.dist | 0.819 |
| s.Sed | 0.818 |
| s.Ex | -0.04 |
| p.Sed | 9.26e-07 |
| p.Ex | 0.811 |
| Gene | Sed | Ex |
|---|---|---|
| Atp5h | 4619 | -2458 |
| Atp5c1 | 4707 | -1751 |
| Atp5e | 3660 | -1998 |
| Atp5o | 2341 | -1474 |
| Atp5l | 4585 | -580 |
| Atp5g1 | 3844 | -451 |
| Atp5j2 | 4434 | -152 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Atp5a1 | 2863 | 945 |
| Atp5b | 3950 | 766 |
| Atp5c1 | 4707 | -1751 |
| Atp5d | 3905 | 1286 |
| Atp5e | 3660 | -1998 |
| Atp5g1 | 3844 | -451 |
| Atp5h | 4619 | -2458 |
| Atp5j | 3965 | 571 |
| Atp5j2 | 4434 | -152 |
| Atp5k | 4798 | 3024 |
| Atp5l | 4585 | -580 |
| Atp5o | 2341 | -1474 |
REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 3.08e-06 |
| p.adjustMANOVA | 0.000101 |
| s.dist | 0.677 |
| s.Sed | 0.558 |
| s.Ex | -0.382 |
| p.Sed | 2.52e-05 |
| p.Ex | 0.00396 |
| Gene | Sed | Ex |
|---|---|---|
| Sdhb | 4495 | -4252 |
| Idh3a | 3658 | -2535 |
| Ogdh | 2568 | -3481 |
| Idh2 | 2048 | -4364 |
| Idh3b | 3150 | -2354 |
| Mdh2 | 3851 | -1814 |
| Cs | 1819 | -3152 |
| Sucla2 | 3908 | -1059 |
| Fh1 | 3548 | -1024 |
| Sdha | 2128 | -1566 |
| Idh3g | 2624 | -1177 |
| Dld | 4023 | -601 |
| Sdhc | 2697 | -550 |
| Dlst | 3010 | -355 |
| Suclg1 | 406 | -2186 |
| Suclg2 | 2491 | -320 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 3944 | 553 |
| Cs | 1819 | -3152 |
| Dld | 4023 | -601 |
| Dlst | 3010 | -355 |
| Fh1 | 3548 | -1024 |
| Idh2 | 2048 | -4364 |
| Idh3a | 3658 | -2535 |
| Idh3b | 3150 | -2354 |
| Idh3g | 2624 | -1177 |
| Mdh2 | 3851 | -1814 |
| Nnt | -2258 | -4629 |
| Ogdh | 2568 | -3481 |
| Sdha | 2128 | -1566 |
| Sdhb | 4495 | -4252 |
| Sdhc | 2697 | -550 |
| Sdhd | 4537 | 1252 |
| Sucla2 | 3908 | -1059 |
| Suclg1 | 406 | -2186 |
| Suclg2 | 2491 | -320 |
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000702 |
| p.adjustMANOVA | 0.00729 |
| s.dist | 0.672 |
| s.Sed | 0.581 |
| s.Ex | -0.337 |
| p.Sed | 0.000842 |
| p.Ex | 0.0533 |
| Gene | Sed | Ex |
|---|---|---|
| Pdk4 | 4509 | -4570 |
| Pdha1 | 4386 | -2900 |
| Pdpr | 4015 | -2855 |
| Dlat | 3069 | -2847 |
| Pdk1 | 3158 | -2409 |
| Pdk2 | 1856 | -3006 |
| Dld | 4023 | -601 |
| Pdhb | 3417 | -658 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Dlat | 3069 | -2847 |
| Dld | 4023 | -601 |
| Pdha1 | 4386 | -2900 |
| Pdhb | 3417 | -658 |
| Pdhx | 3163 | 2622 |
| Pdk1 | 3158 | -2409 |
| Pdk2 | 1856 | -3006 |
| Pdk4 | 4509 | -4570 |
| Pdp1 | 3871 | 4490 |
| Pdp2 | -3790 | -4437 |
| Pdpr | 4015 | -2855 |
REACTOME_COMPLEMENT_CASCADE
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00165 |
| p.adjustMANOVA | 0.0137 |
| s.dist | 0.662 |
| s.Sed | -0.582 |
| s.Ex | 0.315 |
| p.Sed | 0.00145 |
| p.Ex | 0.0845 |
| Gene | Sed | Ex |
|---|---|---|
| C4b | -3859 | 4562 |
| C1qb | -3906 | 4323 |
| C1qa | -4071 | 3813 |
| C3 | -4023 | 2892 |
| C1qc | -3944 | 2655 |
| Cfd | -4437 | 2279 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| C1qa | -4071 | 3813 |
| C1qb | -3906 | 4323 |
| C1qc | -3944 | 2655 |
| C1s1 | -326 | -2411 |
| C3 | -4023 | 2892 |
| C4b | -3859 | 4562 |
| C7 | 2938 | 1440 |
| Cfd | -4437 | 2279 |
| Cr1l | -4004 | -3884 |
| Pros1 | 647 | -1140 |
REACTOME_PYRUVATE_METABOLISM
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 4.69e-05 |
| p.adjustMANOVA | 0.00113 |
| s.dist | 0.651 |
| s.Sed | 0.602 |
| s.Ex | -0.248 |
| p.Sed | 3.05e-05 |
| p.Ex | 0.0862 |
| Gene | Sed | Ex |
|---|---|---|
| Pdk4 | 4509 | -4570 |
| Pdha1 | 4386 | -2900 |
| Pdpr | 4015 | -2855 |
| Dlat | 3069 | -2847 |
| Ldhb | 1746 | -4369 |
| Pdk1 | 3158 | -2409 |
| Pdk2 | 1856 | -3006 |
| Slc16a1 | 4781 | -907 |
| Dld | 4023 | -601 |
| Pdhb | 3417 | -658 |
| Ldha | 757 | -536 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Bsg | 4390 | 65 |
| Dlat | 3069 | -2847 |
| Dld | 4023 | -601 |
| Ldha | 757 | -536 |
| Ldhb | 1746 | -4369 |
| Pdha1 | 4386 | -2900 |
| Pdhb | 3417 | -658 |
| Pdhx | 3163 | 2622 |
| Pdk1 | 3158 | -2409 |
| Pdk2 | 1856 | -3006 |
| Pdk4 | 4509 | -4570 |
| Pdp1 | 3871 | 4490 |
| Pdp2 | -3790 | -4437 |
| Pdpr | 4015 | -2855 |
| Slc16a1 | 4781 | -907 |
| Slc16a3 | 4236 | 4520 |
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
| metric | value |
|---|---|
| setSize | 73 |
| pMANOVA | 3.19e-20 |
| p.adjustMANOVA | 7.28e-18 |
| s.dist | 0.642 |
| s.Sed | 0.641 |
| s.Ex | -0.0374 |
| p.Sed | 2.75e-21 |
| p.Ex | 0.582 |
| Gene | Sed | Ex |
|---|---|---|
| Etfdh | 4736 | -4299 |
| Sdhb | 4495 | -4252 |
| Etfa | 4040 | -3825 |
| Etfb | 4492 | -3428 |
| Ndufa5 | 4704 | -2935 |
| Cox6c | 4766 | -2595 |
| Atp5h | 4619 | -2458 |
| Uqcrc2 | 2775 | -3601 |
| Cox6b1 | 4135 | -2177 |
| Ndufv2 | 3925 | -2284 |
| Ndufa8 | 2361 | -3720 |
| Atp5c1 | 4707 | -1751 |
| Uqcrq | 4171 | -1862 |
| Atp5e | 3660 | -1998 |
| Ndufb7 | 3270 | -1622 |
| Cycs | 4635 | -846 |
| Ndufs5 | 4305 | -837 |
| Ndufs1 | 4394 | -807 |
| Atp5o | 2341 | -1474 |
| Uqcr11 | 3363 | -1012 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Atp5a1 | 2863 | 945 |
| Atp5b | 3950 | 766 |
| Atp5c1 | 4707 | -1751 |
| Atp5d | 3905 | 1286 |
| Atp5e | 3660 | -1998 |
| Atp5g1 | 3844 | -451 |
| Atp5h | 4619 | -2458 |
| Atp5j | 3965 | 571 |
| Atp5j2 | 4434 | -152 |
| Atp5k | 4798 | 3024 |
| Atp5l | 4585 | -580 |
| Atp5o | 2341 | -1474 |
| Cox4i1 | -1134 | -4574 |
| Cox5a | 1560 | -1040 |
| Cox6a1 | -1063 | 2088 |
| Cox6b1 | 4135 | -2177 |
| Cox6c | 4766 | -2595 |
| Cox7a2l | -606 | 2428 |
| Cox7c | 4674 | 2047 |
| Cox8a | -3993 | -585 |
| Cyc1 | 1453 | 2753 |
| Cycs | 4635 | -846 |
| Etfa | 4040 | -3825 |
| Etfb | 4492 | -3428 |
| Etfdh | 4736 | -4299 |
| Ndufa1 | 3328 | -383 |
| Ndufa10 | 3812 | -334 |
| Ndufa11 | 2908 | -41 |
| Ndufa12 | 3827 | 2800 |
| Ndufa13 | 1086 | 3860 |
| Ndufa2 | 4421 | 518 |
| Ndufa3 | -273 | -3509 |
| Ndufa4 | 4701 | 452 |
| Ndufa5 | 4704 | -2935 |
| Ndufa6 | 4096 | 1447 |
| Ndufa7 | 3613 | 1224 |
| Ndufa8 | 2361 | -3720 |
| Ndufa9 | 3609 | 1825 |
| Ndufab1 | 3195 | -299 |
| Ndufb10 | 3391 | -670 |
| Ndufb2 | 4415 | 2377 |
| Ndufb3 | 2884 | 1263 |
| Ndufb4 | 3998 | 621 |
| Ndufb5 | 4365 | -753 |
| Ndufb6 | -528 | 1726 |
| Ndufb7 | 3270 | -1622 |
| Ndufb9 | 4507 | 210 |
| Ndufc1 | 2241 | -138 |
| Ndufc2 | 4287 | 3377 |
| Ndufs1 | 4394 | -807 |
| Ndufs2 | 2947 | 983 |
| Ndufs3 | 2855 | 1072 |
| Ndufs4 | 4422 | 695 |
| Ndufs5 | 4305 | -837 |
| Ndufs6 | 4461 | 2591 |
| Ndufs7 | 2204 | -462 |
| Ndufs8 | 2089 | -54 |
| Ndufv1 | 3015 | -1107 |
| Ndufv2 | 3925 | -2284 |
| Ndufv3 | 2189 | 1048 |
| Sdha | 2128 | -1566 |
| Sdhb | 4495 | -4252 |
| Sdhc | 2697 | -550 |
| Sdhd | 4537 | 1252 |
| Ucp2 | -4385 | 2516 |
| Ucp3 | 2093 | -513 |
| Uqcr11 | 3363 | -1012 |
| Uqcrb | 4081 | 1643 |
| Uqcrc1 | 3916 | 2125 |
| Uqcrc2 | 2775 | -3601 |
| Uqcrfs1 | 4317 | 792 |
| Uqcrh | 4334 | 364 |
| Uqcrq | 4171 | -1862 |
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
| metric | value |
|---|---|
| setSize | 59 |
| pMANOVA | 3.42e-16 |
| p.adjustMANOVA | 5.21e-14 |
| s.dist | 0.636 |
| s.Sed | 0.635 |
| s.Ex | -0.0454 |
| p.Sed | 3.4e-17 |
| p.Ex | 0.547 |
| Gene | Sed | Ex |
|---|---|---|
| Etfdh | 4736 | -4299 |
| Sdhb | 4495 | -4252 |
| Etfa | 4040 | -3825 |
| Etfb | 4492 | -3428 |
| Ndufa5 | 4704 | -2935 |
| Cox6c | 4766 | -2595 |
| Uqcrc2 | 2775 | -3601 |
| Cox6b1 | 4135 | -2177 |
| Ndufv2 | 3925 | -2284 |
| Ndufa8 | 2361 | -3720 |
| Uqcrq | 4171 | -1862 |
| Ndufb7 | 3270 | -1622 |
| Cycs | 4635 | -846 |
| Ndufs5 | 4305 | -837 |
| Ndufs1 | 4394 | -807 |
| Uqcr11 | 3363 | -1012 |
| Ndufv1 | 3015 | -1107 |
| Sdha | 2128 | -1566 |
| Ndufb5 | 4365 | -753 |
| Ndufb10 | 3391 | -670 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Cox4i1 | -1134 | -4574 |
| Cox5a | 1560 | -1040 |
| Cox6a1 | -1063 | 2088 |
| Cox6b1 | 4135 | -2177 |
| Cox6c | 4766 | -2595 |
| Cox7a2l | -606 | 2428 |
| Cox7c | 4674 | 2047 |
| Cox8a | -3993 | -585 |
| Cyc1 | 1453 | 2753 |
| Cycs | 4635 | -846 |
| Etfa | 4040 | -3825 |
| Etfb | 4492 | -3428 |
| Etfdh | 4736 | -4299 |
| Ndufa1 | 3328 | -383 |
| Ndufa10 | 3812 | -334 |
| Ndufa11 | 2908 | -41 |
| Ndufa12 | 3827 | 2800 |
| Ndufa13 | 1086 | 3860 |
| Ndufa2 | 4421 | 518 |
| Ndufa3 | -273 | -3509 |
| Ndufa4 | 4701 | 452 |
| Ndufa5 | 4704 | -2935 |
| Ndufa6 | 4096 | 1447 |
| Ndufa7 | 3613 | 1224 |
| Ndufa8 | 2361 | -3720 |
| Ndufa9 | 3609 | 1825 |
| Ndufab1 | 3195 | -299 |
| Ndufb10 | 3391 | -670 |
| Ndufb2 | 4415 | 2377 |
| Ndufb3 | 2884 | 1263 |
| Ndufb4 | 3998 | 621 |
| Ndufb5 | 4365 | -753 |
| Ndufb6 | -528 | 1726 |
| Ndufb7 | 3270 | -1622 |
| Ndufb9 | 4507 | 210 |
| Ndufc1 | 2241 | -138 |
| Ndufc2 | 4287 | 3377 |
| Ndufs1 | 4394 | -807 |
| Ndufs2 | 2947 | 983 |
| Ndufs3 | 2855 | 1072 |
| Ndufs4 | 4422 | 695 |
| Ndufs5 | 4305 | -837 |
| Ndufs6 | 4461 | 2591 |
| Ndufs7 | 2204 | -462 |
| Ndufs8 | 2089 | -54 |
| Ndufv1 | 3015 | -1107 |
| Ndufv2 | 3925 | -2284 |
| Ndufv3 | 2189 | 1048 |
| Sdha | 2128 | -1566 |
| Sdhb | 4495 | -4252 |
| Sdhc | 2697 | -550 |
| Sdhd | 4537 | 1252 |
| Uqcr11 | 3363 | -1012 |
| Uqcrb | 4081 | 1643 |
| Uqcrc1 | 3916 | 2125 |
| Uqcrc2 | 2775 | -3601 |
| Uqcrfs1 | 4317 | 792 |
| Uqcrh | 4334 | 364 |
| Uqcrq | 4171 | -1862 |
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
| metric | value |
|---|---|
| setSize | 107 |
| pMANOVA | 9.8e-26 |
| p.adjustMANOVA | 4.48e-23 |
| s.dist | 0.604 |
| s.Sed | 0.591 |
| s.Ex | -0.127 |
| p.Sed | 5.08e-26 |
| p.Ex | 0.0238 |
| Gene | Sed | Ex |
|---|---|---|
| Pdk4 | 4509 | -4570 |
| Etfdh | 4736 | -4299 |
| Sdhb | 4495 | -4252 |
| Etfa | 4040 | -3825 |
| Etfb | 4492 | -3428 |
| Ndufa5 | 4704 | -2935 |
| Pdha1 | 4386 | -2900 |
| Cox6c | 4766 | -2595 |
| Pdpr | 4015 | -2855 |
| Atp5h | 4619 | -2458 |
| Uqcrc2 | 2775 | -3601 |
| Idh3a | 3658 | -2535 |
| Cox6b1 | 4135 | -2177 |
| Ndufv2 | 3925 | -2284 |
| Ogdh | 2568 | -3481 |
| Idh2 | 2048 | -4364 |
| Ndufa8 | 2361 | -3720 |
| Dlat | 3069 | -2847 |
| Atp5c1 | 4707 | -1751 |
| Uqcrq | 4171 | -1862 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 3944 | 553 |
| Adhfe1 | -1035 | -3462 |
| Atp5a1 | 2863 | 945 |
| Atp5b | 3950 | 766 |
| Atp5c1 | 4707 | -1751 |
| Atp5d | 3905 | 1286 |
| Atp5e | 3660 | -1998 |
| Atp5g1 | 3844 | -451 |
| Atp5h | 4619 | -2458 |
| Atp5j | 3965 | 571 |
| Atp5j2 | 4434 | -152 |
| Atp5k | 4798 | 3024 |
| Atp5l | 4585 | -580 |
| Atp5o | 2341 | -1474 |
| Bsg | 4390 | 65 |
| Cox4i1 | -1134 | -4574 |
| Cox5a | 1560 | -1040 |
| Cox6a1 | -1063 | 2088 |
| Cox6b1 | 4135 | -2177 |
| Cox6c | 4766 | -2595 |
| Cox7a2l | -606 | 2428 |
| Cox7c | 4674 | 2047 |
| Cox8a | -3993 | -585 |
| Cs | 1819 | -3152 |
| Cyc1 | 1453 | 2753 |
| Cycs | 4635 | -846 |
| D2hgdh | -1707 | 341 |
| Dlat | 3069 | -2847 |
| Dld | 4023 | -601 |
| Dlst | 3010 | -355 |
| Etfa | 4040 | -3825 |
| Etfb | 4492 | -3428 |
| Etfdh | 4736 | -4299 |
| Fh1 | 3548 | -1024 |
| Idh1 | -1557 | -1293 |
| Idh2 | 2048 | -4364 |
| Idh3a | 3658 | -2535 |
| Idh3b | 3150 | -2354 |
| Idh3g | 2624 | -1177 |
| L2hgdh | 2656 | 941 |
| Ldha | 757 | -536 |
| Ldhb | 1746 | -4369 |
| Mdh2 | 3851 | -1814 |
| Ndufa1 | 3328 | -383 |
| Ndufa10 | 3812 | -334 |
| Ndufa11 | 2908 | -41 |
| Ndufa12 | 3827 | 2800 |
| Ndufa13 | 1086 | 3860 |
| Ndufa2 | 4421 | 518 |
| Ndufa3 | -273 | -3509 |
| Ndufa4 | 4701 | 452 |
| Ndufa5 | 4704 | -2935 |
| Ndufa6 | 4096 | 1447 |
| Ndufa7 | 3613 | 1224 |
| Ndufa8 | 2361 | -3720 |
| Ndufa9 | 3609 | 1825 |
| Ndufab1 | 3195 | -299 |
| Ndufb10 | 3391 | -670 |
| Ndufb2 | 4415 | 2377 |
| Ndufb3 | 2884 | 1263 |
| Ndufb4 | 3998 | 621 |
| Ndufb5 | 4365 | -753 |
| Ndufb6 | -528 | 1726 |
| Ndufb7 | 3270 | -1622 |
| Ndufb9 | 4507 | 210 |
| Ndufc1 | 2241 | -138 |
| Ndufc2 | 4287 | 3377 |
| Ndufs1 | 4394 | -807 |
| Ndufs2 | 2947 | 983 |
| Ndufs3 | 2855 | 1072 |
| Ndufs4 | 4422 | 695 |
| Ndufs5 | 4305 | -837 |
| Ndufs6 | 4461 | 2591 |
| Ndufs7 | 2204 | -462 |
| Ndufs8 | 2089 | -54 |
| Ndufv1 | 3015 | -1107 |
| Ndufv2 | 3925 | -2284 |
| Ndufv3 | 2189 | 1048 |
| Nnt | -2258 | -4629 |
| Ogdh | 2568 | -3481 |
| Pdha1 | 4386 | -2900 |
| Pdhb | 3417 | -658 |
| Pdhx | 3163 | 2622 |
| Pdk1 | 3158 | -2409 |
| Pdk2 | 1856 | -3006 |
| Pdk4 | 4509 | -4570 |
| Pdp1 | 3871 | 4490 |
| Pdp2 | -3790 | -4437 |
| Pdpr | 4015 | -2855 |
| Sdha | 2128 | -1566 |
| Sdhb | 4495 | -4252 |
| Sdhc | 2697 | -550 |
| Sdhd | 4537 | 1252 |
| Slc16a1 | 4781 | -907 |
| Slc16a3 | 4236 | 4520 |
| Sucla2 | 3908 | -1059 |
| Suclg1 | 406 | -2186 |
| Suclg2 | 2491 | -320 |
| Ucp2 | -4385 | 2516 |
| Ucp3 | 2093 | -513 |
| Uqcr11 | 3363 | -1012 |
| Uqcrb | 4081 | 1643 |
| Uqcrc1 | 3916 | 2125 |
| Uqcrc2 | 2775 | -3601 |
| Uqcrfs1 | 4317 | 792 |
| Uqcrh | 4334 | 364 |
| Uqcrq | 4171 | -1862 |
REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0012 |
| p.adjustMANOVA | 0.0108 |
| s.dist | 0.594 |
| s.Sed | -0.53 |
| s.Ex | 0.269 |
| p.Sed | 0.000945 |
| p.Ex | 0.093 |
| Gene | Sed | Ex |
|---|---|---|
| Prkcsh | -4118 | 3836 |
| Mogs | -2506 | 4352 |
| Mlec | -2674 | 3880 |
| Man1b1 | -3700 | 2777 |
| Edem2 | -2715 | 3215 |
| Calr | -3917 | 1891 |
| Ganab | -2066 | 1153 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Calr | -3917 | 1891 |
| Canx | -3475 | -2410 |
| Edem1 | -4318 | -682 |
| Edem2 | -2715 | 3215 |
| Edem3 | 3048 | 1221 |
| Ganab | -2066 | 1153 |
| Man1b1 | -3700 | 2777 |
| Mlec | -2674 | 3880 |
| Mogs | -2506 | 4352 |
| Pdia3 | -3056 | -3982 |
| Prkcsh | -4118 | 3836 |
| Uggt1 | -2696 | -280 |
| Uggt2 | 2849 | 1145 |
REACTOME_PEPTIDE_CHAIN_ELONGATION
| metric | value |
|---|---|
| setSize | 66 |
| pMANOVA | 2.95e-15 |
| p.adjustMANOVA | 3.37e-13 |
| s.dist | 0.589 |
| s.Sed | -0.528 |
| s.Ex | 0.26 |
| p.Sed | 1.19e-13 |
| p.Ex | 0.000261 |
| Gene | Sed | Ex |
|---|---|---|
| Rpl37a | -3905 | 4049 |
| Rpl5 | -3992 | 3942 |
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Rpl18a | -4096 | 2967 |
| Rpsa | -3512 | 3186 |
| Rps14 | -2630 | 4064 |
| Rplp2 | -3371 | 2764 |
| Rps8 | -3862 | 2318 |
| Rpl14 | -3324 | 2450 |
| Rps15a | -3210 | 2480 |
| Rplp0 | -3918 | 1684 |
| Rpl10a | -1820 | 3571 |
| Rps9 | -3991 | 1585 |
| Rpl8 | -3895 | 1539 |
| Eef1a1 | -4423 | 1057 |
| Rps25 | -3437 | 1296 |
| Rps3a1 | -3863 | 1143 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Eef1a1 | -4423.0 | 1057.0 |
| Eef2 | -1936.0 | 720.0 |
| Rpl10a | -1820.0 | 3571.0 |
| Rpl11 | -4233.0 | 1016.0 |
| Rpl12 | -4366.0 | 281.0 |
| Rpl13 | -2635.0 | 1005.0 |
| Rpl14 | -3324.0 | 2450.0 |
| Rpl15 | -2235.0 | 682.0 |
| Rpl18 | -2154.0 | 673.0 |
| Rpl18a | -4096.0 | 2967.0 |
| Rpl19 | -1550.0 | 1822.0 |
| Rpl22 | -2022.0 | -1577.0 |
| Rpl23 | -3192.0 | -63.0 |
| Rpl23a | -1746.0 | -1151.0 |
| Rpl24 | 1967.0 | -1516.0 |
| Rpl26 | -2917.0 | 1295.0 |
| Rpl27-ps3 | 997.5 | -4491.5 |
| Rpl27a | -740.0 | 3469.0 |
| Rpl28 | -3311.0 | 384.0 |
| Rpl29 | -1496.0 | 1580.0 |
| Rpl3 | -4399.0 | 641.0 |
| Rpl30 | -3898.0 | 753.0 |
| Rpl32 | -2024.0 | -114.0 |
| Rpl34 | -1828.0 | 264.0 |
| Rpl35 | -255.0 | 944.0 |
| Rpl36al | -378.0 | -968.0 |
| Rpl37 | -855.0 | -3821.0 |
| Rpl37a | -3905.0 | 4049.0 |
| Rpl38 | -3823.0 | 685.0 |
| Rpl39 | 1968.0 | -908.0 |
| Rpl3l | 3961.0 | -1994.0 |
| Rpl4 | -2331.0 | 1640.0 |
| Rpl41 | -550.0 | 688.0 |
| Rpl5 | -3992.0 | 3942.0 |
| Rpl6 | -3716.0 | 935.0 |
| Rpl8 | -3895.0 | 1539.0 |
| Rplp0 | -3918.0 | 1684.0 |
| Rplp1 | -388.0 | 3710.0 |
| Rplp2 | -3371.0 | 2764.0 |
| Rps11 | -2961.0 | 37.0 |
| Rps13 | -3562.0 | 3659.0 |
| Rps14 | -2630.0 | 4064.0 |
| Rps15a | -3210.0 | 2480.0 |
| Rps16 | -3737.0 | 417.0 |
| Rps17 | 718.0 | 3046.0 |
| Rps18 | -4174.0 | -2157.0 |
| Rps19 | -980.0 | 2899.0 |
| Rps20 | -3688.0 | 3874.0 |
| Rps21 | -161.0 | 1078.0 |
| Rps23 | -3757.0 | 817.0 |
| Rps24 | -3792.0 | 195.0 |
| Rps25 | -3437.0 | 1296.0 |
| Rps26 | -3327.0 | 3699.0 |
| Rps27 | -441.0 | 2984.0 |
| Rps27a | -405.0 | 3577.0 |
| Rps29 | 4565.0 | 1750.0 |
| Rps3 | -4328.0 | 558.0 |
| Rps3a1 | -3863.0 | 1143.0 |
| Rps4x | -4218.0 | 3694.0 |
| Rps5 | -2098.0 | 982.0 |
| Rps6 | -4242.0 | -1590.0 |
| Rps7 | -4205.0 | -2011.0 |
| Rps8 | -3862.0 | 2318.0 |
| Rps9 | -3991.0 | 1585.0 |
| Rpsa | -3512.0 | 3186.0 |
| Uba52 | 4493.0 | 4487.0 |
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
| metric | value |
|---|---|
| setSize | 38 |
| pMANOVA | 4.73e-09 |
| p.adjustMANOVA | 1.97e-07 |
| s.dist | 0.588 |
| s.Sed | 0.498 |
| s.Ex | -0.312 |
| p.Sed | 1.08e-07 |
| p.Ex | 0.000873 |
| Gene | Sed | Ex |
|---|---|---|
| Pdk4 | 4509 | -4570 |
| Sdhb | 4495 | -4252 |
| Pdha1 | 4386 | -2900 |
| Pdpr | 4015 | -2855 |
| Idh3a | 3658 | -2535 |
| Ogdh | 2568 | -3481 |
| Idh2 | 2048 | -4364 |
| Dlat | 3069 | -2847 |
| Ldhb | 1746 | -4369 |
| Pdk1 | 3158 | -2409 |
| Idh3b | 3150 | -2354 |
| Mdh2 | 3851 | -1814 |
| Cs | 1819 | -3152 |
| Pdk2 | 1856 | -3006 |
| Slc16a1 | 4781 | -907 |
| Sucla2 | 3908 | -1059 |
| Fh1 | 3548 | -1024 |
| Sdha | 2128 | -1566 |
| Idh3g | 2624 | -1177 |
| Dld | 4023 | -601 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 3944 | 553 |
| Adhfe1 | -1035 | -3462 |
| Bsg | 4390 | 65 |
| Cs | 1819 | -3152 |
| D2hgdh | -1707 | 341 |
| Dlat | 3069 | -2847 |
| Dld | 4023 | -601 |
| Dlst | 3010 | -355 |
| Fh1 | 3548 | -1024 |
| Idh1 | -1557 | -1293 |
| Idh2 | 2048 | -4364 |
| Idh3a | 3658 | -2535 |
| Idh3b | 3150 | -2354 |
| Idh3g | 2624 | -1177 |
| L2hgdh | 2656 | 941 |
| Ldha | 757 | -536 |
| Ldhb | 1746 | -4369 |
| Mdh2 | 3851 | -1814 |
| Nnt | -2258 | -4629 |
| Ogdh | 2568 | -3481 |
| Pdha1 | 4386 | -2900 |
| Pdhb | 3417 | -658 |
| Pdhx | 3163 | 2622 |
| Pdk1 | 3158 | -2409 |
| Pdk2 | 1856 | -3006 |
| Pdk4 | 4509 | -4570 |
| Pdp1 | 3871 | 4490 |
| Pdp2 | -3790 | -4437 |
| Pdpr | 4015 | -2855 |
| Sdha | 2128 | -1566 |
| Sdhb | 4495 | -4252 |
| Sdhc | 2697 | -550 |
| Sdhd | 4537 | 1252 |
| Slc16a1 | 4781 | -907 |
| Slc16a3 | 4236 | 4520 |
| Sucla2 | 3908 | -1059 |
| Suclg1 | 406 | -2186 |
| Suclg2 | 2491 | -320 |
REACTOME_G_PROTEIN_ACTIVATION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00902 |
| p.adjustMANOVA | 0.0458 |
| s.dist | 0.553 |
| s.Sed | -0.47 |
| s.Ex | -0.292 |
| p.Sed | 0.0101 |
| p.Ex | 0.11 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb4 | -3440 | -4494 |
| Gnao1 | -2204 | -4216 |
| Gnb5 | -1086 | -4561 |
| Gnai3 | -2975 | -1402 |
| Gnb1 | -763 | -1610 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gnai2 | -4237 | 2747 |
| Gnai3 | -2975 | -1402 |
| Gnao1 | -2204 | -4216 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00616 |
| p.adjustMANOVA | 0.0352 |
| s.dist | 0.552 |
| s.Sed | 0.136 |
| s.Ex | 0.534 |
| p.Sed | 0.434 |
| p.Ex | 0.00215 |
| Gene | Sed | Ex |
|---|---|---|
| Phka1 | 3019 | 4550 |
| Gyg | 4657 | 2601 |
| Pgm1 | 2598 | 3087 |
| Phkb | 2134 | 3585 |
| Phkg1 | 1109 | 3400 |
| Agl | 249 | 2630 |
| Phka2 | 12 | 3506 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agl | 249 | 2630 |
| Calm1 | 454 | -3493 |
| Gyg | 4657 | 2601 |
| Pgm1 | 2598 | 3087 |
| Phka1 | 3019 | 4550 |
| Phka2 | 12 | 3506 |
| Phkb | 2134 | 3585 |
| Phkg1 | 1109 | 3400 |
| Phkg2 | -2268 | 3414 |
| Pygb | -2126 | 642 |
| Pygm | -797 | 3210 |
REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00666 |
| p.adjustMANOVA | 0.0376 |
| s.dist | 0.544 |
| s.Sed | -0.339 |
| s.Ex | -0.425 |
| p.Sed | 0.0518 |
| p.Ex | 0.0147 |
| Gene | Sed | Ex |
|---|---|---|
| Akt3 | -3718 | -4283 |
| Gnb4 | -3440 | -4494 |
| Akt1 | -3296 | -2715 |
| Pdpk1 | -1738 | -4479 |
| Gnb5 | -1086 | -4561 |
| Gnb1 | -763 | -1610 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3296 | -2715 |
| Akt2 | 4030 | 474 |
| Akt3 | -3718 | -4283 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
| Pdpk1 | -1738 | -4479 |
REACTOME_CALNEXIN_CALRETICULIN_CYCLE
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00886 |
| p.adjustMANOVA | 0.0455 |
| s.dist | 0.54 |
| s.Sed | -0.517 |
| s.Ex | 0.156 |
| p.Sed | 0.00302 |
| p.Ex | 0.371 |
| Gene | Sed | Ex |
|---|---|---|
| Prkcsh | -4118 | 3836 |
| Man1b1 | -3700 | 2777 |
| Edem2 | -2715 | 3215 |
| Calr | -3917 | 1891 |
| Ganab | -2066 | 1153 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Calr | -3917 | 1891 |
| Canx | -3475 | -2410 |
| Edem1 | -4318 | -682 |
| Edem2 | -2715 | 3215 |
| Edem3 | 3048 | 1221 |
| Ganab | -2066 | 1153 |
| Man1b1 | -3700 | 2777 |
| Pdia3 | -3056 | -3982 |
| Prkcsh | -4118 | 3836 |
| Uggt1 | -2696 | -280 |
| Uggt2 | 2849 | 1145 |
REACTOME_METABOLISM_OF_POLYAMINES
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00465 |
| p.adjustMANOVA | 0.0291 |
| s.dist | 0.539 |
| s.Sed | 0.46 |
| s.Ex | 0.281 |
| p.Sed | 0.00576 |
| p.Ex | 0.092 |
| Gene | Sed | Ex |
|---|---|---|
| Smox | 4211 | 4549 |
| Odc1 | 4483 | 3897 |
| Sms | 4163 | 3838 |
| Adi1 | 1412 | 2173 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adi1 | 1412 | 2173 |
| Amd1 | -982 | 2705 |
| Apip | 2975 | -2273 |
| Enoph1 | -1490 | 3870 |
| Got1 | 4371 | -2992 |
| Mri1 | 3921 | -1526 |
| Mtap | 4102 | -1112 |
| Odc1 | 4483 | 3897 |
| Sat1 | -3797 | 4253 |
| Smox | 4211 | 4549 |
| Sms | 4163 | 3838 |
| Srm | 4472 | -1848 |
REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00742 |
| p.adjustMANOVA | 0.0401 |
| s.dist | 0.538 |
| s.Sed | -0.417 |
| s.Ex | -0.339 |
| p.Sed | 0.0166 |
| p.Ex | 0.0515 |
| Gene | Sed | Ex |
|---|---|---|
| Fabp4 | -4189 | -4122 |
| Lipe | -4299 | -3746 |
| Ppp1cb | -1492 | -4618 |
| Mgll | -1289 | -2798 |
| Cav1 | -558 | -4558 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Abhd5 | 2346 | -3903 |
| Cav1 | -558 | -4558 |
| Fabp4 | -4189 | -4122 |
| Lipe | -4299 | -3746 |
| Mgll | -1289 | -2798 |
| Plin1 | -4426 | 4120 |
| Ppp1ca | -1552 | 2867 |
| Ppp1cb | -1492 | -4618 |
| Ppp1cc | -555 | 1819 |
| Prkaca | 1010 | -2905 |
| Prkacb | -4104 | 545 |
REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00749 |
| p.adjustMANOVA | 0.0401 |
| s.dist | 0.537 |
| s.Sed | -0.339 |
| s.Ex | -0.416 |
| p.Sed | 0.0515 |
| p.Ex | 0.0168 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb4 | -3440 | -4494 |
| P2ry1 | -3358 | -4086 |
| Gnb5 | -1086 | -4561 |
| Mapk14 | -1671 | -1864 |
| Gnb1 | -763 | -1610 |
| Gnaq | -719 | -963 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gna11 | 1005 | -3655 |
| Gnaq | -719 | -963 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
| Mapk14 | -1671 | -1864 |
| P2ry1 | -3358 | -4086 |
REACTOME_NCAM1_INTERACTIONS
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00203 |
| p.adjustMANOVA | 0.016 |
| s.dist | 0.53 |
| s.Sed | -0.197 |
| s.Ex | 0.493 |
| p.Sed | 0.187 |
| p.Ex | 0.000961 |
| Gene | Sed | Ex |
|---|---|---|
| Nrtn | -3943 | 3138 |
| Col6a1 | -2772 | 3674 |
| Col1a2 | -2244 | 4395 |
| Col3a1 | -1440 | 4464 |
| Col5a2 | -1113 | 3431 |
| Col1a1 | -825 | 4308 |
| Col4a2 | -1127 | 2348 |
| Agrn | -979 | 1882 |
| Col4a1 | -425 | 2514 |
| Col6a2 | -32 | 834 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agrn | -979 | 1882 |
| Cacna1s | 3368 | -3747 |
| Cacnb1 | -2078 | -4061 |
| Col1a1 | -825 | 4308 |
| Col1a2 | -2244 | 4395 |
| Col3a1 | -1440 | 4464 |
| Col4a1 | -425 | 2514 |
| Col4a2 | -1127 | 2348 |
| Col5a1 | 925 | 3237 |
| Col5a2 | -1113 | 3431 |
| Col6a1 | -2772 | 3674 |
| Col6a2 | -32 | 834 |
| Col6a3 | 605 | 3975 |
| Nrtn | -3943 | 3138 |
| Prnp | 1300 | 3682 |
REACTOME_INTERFERON_GAMMA_SIGNALING
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 9.7e-05 |
| p.adjustMANOVA | 0.00193 |
| s.dist | 0.514 |
| s.Sed | -0.35 |
| s.Ex | 0.377 |
| p.Sed | 0.00298 |
| p.Ex | 0.00141 |
| Gene | Sed | Ex |
|---|---|---|
| H2-Aa | -4380 | 4605 |
| H2-Eb1 | -4401 | 4501 |
| Prkcd | -4103 | 4537 |
| Irf9 | -4151 | 4398 |
| Ptpn2 | -2040 | 4424 |
| Camk2d | -3083 | 2741 |
| Ptpn1 | -3673 | 1735 |
| Irf8 | -4359 | 1178 |
| Gbp7 | -2993 | 1430 |
| Ifngr1 | -2598 | 1020 |
| Irf2 | -947 | 1701 |
| Sumo1 | -166 | 3594 |
| B2m | -4307 | 44 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| B2m | -4307 | 44.0 |
| Camk2a | 2674 | 4035.0 |
| Camk2b | 2537 | 2946.0 |
| Camk2d | -3083 | 2741.0 |
| Cd44 | 3452 | -2142.5 |
| Gbp7 | -2993 | 1430.0 |
| H2-Aa | -4380 | 4605.0 |
| H2-Eb1 | -4401 | 4501.0 |
| Ifngr1 | -2598 | 1020.0 |
| Ifngr2 | -1877 | -1187.0 |
| Irf1 | 228 | -2892.0 |
| Irf2 | -947 | 1701.0 |
| Irf3 | 3355 | 4506.0 |
| Irf5 | -3574 | -159.0 |
| Irf8 | -4359 | 1178.0 |
| Irf9 | -4151 | 4398.0 |
| Jak1 | 992 | 2277.0 |
| Jak2 | 4683 | 1892.0 |
| Pias1 | -1407 | -3372.0 |
| Prkcd | -4103 | 4537.0 |
| Ptpn1 | -3673 | 1735.0 |
| Ptpn2 | -2040 | 4424.0 |
| Stat1 | -4090 | -185.0 |
| Sumo1 | -166 | 3594.0 |
REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000548 |
| p.adjustMANOVA | 0.00623 |
| s.dist | 0.499 |
| s.Sed | 0.0595 |
| s.Ex | 0.495 |
| p.Sed | 0.645 |
| p.Ex | 0.000127 |
| Gene | Sed | Ex |
|---|---|---|
| Lars2 | 3730 | 4616 |
| Dars2 | 3105 | 2995 |
| Kars | 4440 | 1909 |
| Ppa2 | 4576 | 1397 |
| Sars2 | 1091 | 3258 |
| Rars2 | 900 | 3566 |
| Ears2 | 518 | 4108 |
| Yars2 | 3551 | 592 |
| Gars | 322 | 3814 |
| Tars2 | 95 | 1491 |
| Wars2 | 90 | 1265 |
| Fars2 | 97 | 528 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aars2 | -123 | 2039.0 |
| Cars2 | -2793 | 4158.0 |
| Dars2 | 3105 | 2995.0 |
| Ears2 | 518 | 4108.0 |
| Fars2 | 97 | 528.0 |
| Gars | 322 | 3814.0 |
| Hars2 | -1880 | 3539.0 |
| Iars2 | -1109 | 2552.0 |
| Kars | 4440 | 1909.0 |
| Lars2 | 3730 | 4616.0 |
| Mars2 | -2835 | -554.0 |
| Nars2 | -2347 | 900.0 |
| Ppa2 | 4576 | 1397.0 |
| Qars | -1613 | 3809.0 |
| Rars2 | 900 | 3566.0 |
| Sars2 | 1091 | 3258.0 |
| Tars2 | 95 | 1491.0 |
| Vars2 | -489 | -321.5 |
| Wars2 | 90 | 1265.0 |
| Yars2 | 3551 | 592.0 |
REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 1.84e-14 |
| p.adjustMANOVA | 1.68e-12 |
| s.dist | 0.497 |
| s.Sed | -0.431 |
| s.Ex | 0.248 |
| p.Sed | 3.12e-12 |
| p.Ex | 5.9e-05 |
| Gene | Sed | Ex |
|---|---|---|
| Rpl37a | -3905 | 4049 |
| Rpl5 | -3992 | 3942 |
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Sec11c | -3541 | 3449 |
| Rpl18a | -4096 | 2967 |
| Rpsa | -3512 | 3186 |
| Rps14 | -2630 | 4064 |
| Rplp2 | -3371 | 2764 |
| Rps8 | -3862 | 2318 |
| Rpl14 | -3324 | 2450 |
| Rps15a | -3210 | 2480 |
| Ssr2 | -2915 | 2641 |
| Rpn2 | -2738 | 2609 |
| Rplp0 | -3918 | 1684 |
| Rpl10a | -1820 | 3571 |
| Rps9 | -3991 | 1585 |
| Rpl8 | -3895 | 1539 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Ddost | 727.0 | 3306.0 |
| Rpl10a | -1820.0 | 3571.0 |
| Rpl11 | -4233.0 | 1016.0 |
| Rpl12 | -4366.0 | 281.0 |
| Rpl13 | -2635.0 | 1005.0 |
| Rpl14 | -3324.0 | 2450.0 |
| Rpl15 | -2235.0 | 682.0 |
| Rpl18 | -2154.0 | 673.0 |
| Rpl18a | -4096.0 | 2967.0 |
| Rpl19 | -1550.0 | 1822.0 |
| Rpl22 | -2022.0 | -1577.0 |
| Rpl23 | -3192.0 | -63.0 |
| Rpl23a | -1746.0 | -1151.0 |
| Rpl24 | 1967.0 | -1516.0 |
| Rpl26 | -2917.0 | 1295.0 |
| Rpl27-ps3 | 997.5 | -4491.5 |
| Rpl27a | -740.0 | 3469.0 |
| Rpl28 | -3311.0 | 384.0 |
| Rpl29 | -1496.0 | 1580.0 |
| Rpl3 | -4399.0 | 641.0 |
| Rpl30 | -3898.0 | 753.0 |
| Rpl32 | -2024.0 | -114.0 |
| Rpl34 | -1828.0 | 264.0 |
| Rpl35 | -255.0 | 944.0 |
| Rpl36al | -378.0 | -968.0 |
| Rpl37 | -855.0 | -3821.0 |
| Rpl37a | -3905.0 | 4049.0 |
| Rpl38 | -3823.0 | 685.0 |
| Rpl39 | 1968.0 | -908.0 |
| Rpl3l | 3961.0 | -1994.0 |
| Rpl4 | -2331.0 | 1640.0 |
| Rpl41 | -550.0 | 688.0 |
| Rpl5 | -3992.0 | 3942.0 |
| Rpl6 | -3716.0 | 935.0 |
| Rpl8 | -3895.0 | 1539.0 |
| Rplp0 | -3918.0 | 1684.0 |
| Rplp1 | -388.0 | 3710.0 |
| Rplp2 | -3371.0 | 2764.0 |
| Rpn1 | 4416.0 | 2819.0 |
| Rpn2 | -2738.0 | 2609.0 |
| Rps11 | -2961.0 | 37.0 |
| Rps13 | -3562.0 | 3659.0 |
| Rps14 | -2630.0 | 4064.0 |
| Rps15a | -3210.0 | 2480.0 |
| Rps16 | -3737.0 | 417.0 |
| Rps17 | 718.0 | 3046.0 |
| Rps18 | -4174.0 | -2157.0 |
| Rps19 | -980.0 | 2899.0 |
| Rps20 | -3688.0 | 3874.0 |
| Rps21 | -161.0 | 1078.0 |
| Rps23 | -3757.0 | 817.0 |
| Rps24 | -3792.0 | 195.0 |
| Rps25 | -3437.0 | 1296.0 |
| Rps26 | -3327.0 | 3699.0 |
| Rps27 | -441.0 | 2984.0 |
| Rps27a | -405.0 | 3577.0 |
| Rps29 | 4565.0 | 1750.0 |
| Rps3 | -4328.0 | 558.0 |
| Rps3a1 | -3863.0 | 1143.0 |
| Rps4x | -4218.0 | 3694.0 |
| Rps5 | -2098.0 | 982.0 |
| Rps6 | -4242.0 | -1590.0 |
| Rps7 | -4205.0 | -2011.0 |
| Rps8 | -3862.0 | 2318.0 |
| Rps9 | -3991.0 | 1585.0 |
| Rpsa | -3512.0 | 3186.0 |
| Sec11a | -219.0 | 4394.0 |
| Sec11c | -3541.0 | 3449.0 |
| Sec61a1 | -4129.0 | 401.0 |
| Sec61a2 | -3553.0 | -4190.0 |
| Sec61b | 254.0 | 3529.0 |
| Sec61g | -3967.0 | -239.0 |
| Spcs1 | 3978.0 | 4332.0 |
| Spcs2 | 2424.0 | -137.0 |
| Spcs3 | -2541.0 | -3242.0 |
| Srp14 | -1379.0 | 4006.0 |
| Srp19 | 1695.0 | 1042.0 |
| Srp54a | 4258.0 | -3261.0 |
| Srp68 | -2335.0 | -3369.0 |
| Srp72 | 1172.0 | 2384.0 |
| Srp9 | -2058.0 | 2556.0 |
| Srprb | -1145.0 | -2573.0 |
| Ssr1 | -1543.0 | 3116.0 |
| Ssr2 | -2915.0 | 2641.0 |
| Ssr3 | 4403.0 | 3601.0 |
| Ssr4 | -3178.0 | -2538.0 |
| Tram1 | -3725.0 | -1735.0 |
| Uba52 | 4493.0 | 4487.0 |
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.00265 |
| p.adjustMANOVA | 0.0192 |
| s.dist | 0.497 |
| s.Sed | 0.0285 |
| s.Ex | 0.496 |
| p.Sed | 0.843 |
| p.Ex | 0.000599 |
| Gene | Sed | Ex |
|---|---|---|
| Grip2 | 4209 | 4614 |
| Camk2a | 2674 | 4035 |
| Pick1 | 3470 | 2280 |
| Camk2b | 2537 | 2946 |
| Dlg1 | 2865 | 2463 |
| Ap2b1 | 2410 | 2061 |
| Mdm2 | 2357 | 1873 |
| Prkca | 977 | 2681 |
| Myo6 | 170 | 4244 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Ap2a1 | -1928 | 2227 |
| Ap2a2 | -3559 | -889 |
| Ap2b1 | 2410 | 2061 |
| Ap2m1 | -1370 | -2318 |
| Ap2s1 | -2294 | 3903 |
| Camk2a | 2674 | 4035 |
| Camk2b | 2537 | 2946 |
| Camk2d | -3083 | 2741 |
| Dlg1 | 2865 | 2463 |
| Epb41l1 | -1281 | -673 |
| Grip2 | 4209 | 4614 |
| Mdm2 | 2357 | 1873 |
| Myo6 | 170 | 4244 |
| Nsf | -2980 | 4389 |
| Pick1 | 3470 | 2280 |
| Prkca | 977 | 2681 |
REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0139 |
| p.adjustMANOVA | 0.0644 |
| s.dist | 0.481 |
| s.Sed | -0.276 |
| s.Ex | -0.393 |
| p.Sed | 0.0974 |
| p.Ex | 0.0183 |
| Gene | Sed | Ex |
|---|---|---|
| Akt3 | -3718 | -4283 |
| Gnb4 | -3440 | -4494 |
| Akt1 | -3296 | -2715 |
| Pdpk1 | -1738 | -4479 |
| Gnb5 | -1086 | -4561 |
| Gnb1 | -763 | -1610 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3296 | -2715 |
| Akt2 | 4030 | 474 |
| Akt3 | -3718 | -4283 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
| Pdpk1 | -1738 | -4479 |
| Plcb3 | 2087 | -212 |
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.00392 |
| p.adjustMANOVA | 0.0252 |
| s.dist | 0.474 |
| s.Sed | -0.399 |
| s.Ex | -0.257 |
| p.Sed | 0.00579 |
| p.Ex | 0.0749 |
| Gene | Sed | Ex |
|---|---|---|
| Pik3cd | -4345 | -4155 |
| Pik3r1 | -3893 | -3036 |
| Nck1 | -3508 | -3039 |
| Sh3kbp1 | -1999 | -4278 |
| Grb2 | -3740 | -2002 |
| Plcg1 | -3840 | -1307 |
| Itpr2 | -1107 | -3046 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Calm1 | 454 | -3493 |
| Cbl | -4046 | 2459 |
| Cblb | 2426 | 2696 |
| Fyn | -939 | 3967 |
| Grb2 | -3740 | -2002 |
| Itpr2 | -1107 | -3046 |
| Lyn | -3916 | 2875 |
| Nck1 | -3508 | -3039 |
| Orai1 | 1658 | 950 |
| Pik3cd | -4345 | -4155 |
| Pik3r1 | -3893 | -3036 |
| Plcg1 | -3840 | -1307 |
| Sh3kbp1 | -1999 | -4278 |
| Shc1 | -2560 | 689 |
| Sos1 | 893 | -4117 |
| Stim1 | 2054 | -4257 |
REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
| metric | value |
|---|---|
| setSize | 41 |
| pMANOVA | 1.6e-06 |
| p.adjustMANOVA | 6.1e-05 |
| s.dist | 0.472 |
| s.Sed | -0.428 |
| s.Ex | 0.197 |
| p.Sed | 2.11e-06 |
| p.Ex | 0.029 |
| Gene | Sed | Ex |
|---|---|---|
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Rpsa | -3512 | 3186 |
| Rps14 | -2630 | 4064 |
| Rps8 | -3862 | 2318 |
| Rps15a | -3210 | 2480 |
| Rps9 | -3991 | 1585 |
| Rps25 | -3437 | 1296 |
| Rps3a1 | -3863 | 1143 |
| Eif3b | -2573 | 1653 |
| Rps23 | -3757 | 817 |
| Rps19 | -980 | 2899 |
| Rps3 | -4328 | 558 |
| Rps5 | -2098 | 982 |
| Rps16 | -3737 | 417 |
| Rps27a | -405 | 3577 |
| Rps27 | -441 | 2984 |
| Eif3g | -750 | 1101 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Eif1ax | -1582 | -3794 |
| Eif2s1 | 3422 | 2411 |
| Eif2s2 | 4151 | 2919 |
| Eif2s3x | -2356 | -702 |
| Eif3a | 3103 | -2833 |
| Eif3b | -2573 | 1653 |
| Eif3c | -346 | -432 |
| Eif3d | -798 | -442 |
| Eif3e | -1404 | -740 |
| Eif3f | -3081 | -1711 |
| Eif3g | -750 | 1101 |
| Eif3h | -2518 | -2879 |
| Eif3i | 2507 | 2009 |
| Eif3j2 | 1699 | -667 |
| Eif3k | -3262 | -2381 |
| Rps11 | -2961 | 37 |
| Rps13 | -3562 | 3659 |
| Rps14 | -2630 | 4064 |
| Rps15a | -3210 | 2480 |
| Rps16 | -3737 | 417 |
| Rps17 | 718 | 3046 |
| Rps18 | -4174 | -2157 |
| Rps19 | -980 | 2899 |
| Rps20 | -3688 | 3874 |
| Rps21 | -161 | 1078 |
| Rps23 | -3757 | 817 |
| Rps24 | -3792 | 195 |
| Rps25 | -3437 | 1296 |
| Rps26 | -3327 | 3699 |
| Rps27 | -441 | 2984 |
| Rps27a | -405 | 3577 |
| Rps29 | 4565 | 1750 |
| Rps3 | -4328 | 558 |
| Rps3a1 | -3863 | 1143 |
| Rps4x | -4218 | 3694 |
| Rps5 | -2098 | 982 |
| Rps6 | -4242 | -1590 |
| Rps7 | -4205 | -2011 |
| Rps8 | -3862 | 2318 |
| Rps9 | -3991 | 1585 |
| Rpsa | -3512 | 3186 |
REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
| metric | value |
|---|---|
| setSize | 82 |
| pMANOVA | 4.68e-12 |
| p.adjustMANOVA | 3.56e-10 |
| s.dist | 0.467 |
| s.Sed | -0.428 |
| s.Ex | 0.186 |
| p.Sed | 2.2e-11 |
| p.Ex | 0.00367 |
| Gene | Sed | Ex |
|---|---|---|
| Rpl37a | -3905 | 4049 |
| Rpl5 | -3992 | 3942 |
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Rpl18a | -4096 | 2967 |
| Rpsa | -3512 | 3186 |
| Rps14 | -2630 | 4064 |
| Polr2a | -3855 | 2581 |
| Rplp2 | -3371 | 2764 |
| Rps8 | -3862 | 2318 |
| Rpl14 | -3324 | 2450 |
| Rps15a | -3210 | 2480 |
| Rplp0 | -3918 | 1684 |
| Rpl10a | -1820 | 3571 |
| Rps9 | -3991 | 1585 |
| Rpl8 | -3895 | 1539 |
| Polr2g | -3118 | 1690 |
| Gtf2f2 | -2108 | 2244 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Dnajc3 | 820.0 | 156.0 |
| Grsf1 | 4037.0 | -4249.0 |
| Gtf2f1 | 433.0 | 1152.0 |
| Gtf2f2 | -2108.0 | 2244.0 |
| Hsp90aa1 | 2556.0 | -4071.0 |
| Ipo5 | 1761.0 | -2131.0 |
| Polr2a | -3855.0 | 2581.0 |
| Polr2b | -2692.0 | -708.0 |
| Polr2c | -822.0 | -1229.0 |
| Polr2d | 2414.0 | 2119.0 |
| Polr2e | -2634.0 | -284.0 |
| Polr2f | -2832.0 | -1959.0 |
| Polr2g | -3118.0 | 1690.0 |
| Polr2h | -3127.0 | -2058.0 |
| Polr2i | 2901.0 | -2456.0 |
| Polr2j | -2391.0 | -1032.0 |
| Polr2k | 3087.0 | -1180.0 |
| Polr2l | 1477.0 | 4132.0 |
| Rpl10a | -1820.0 | 3571.0 |
| Rpl11 | -4233.0 | 1016.0 |
| Rpl12 | -4366.0 | 281.0 |
| Rpl13 | -2635.0 | 1005.0 |
| Rpl14 | -3324.0 | 2450.0 |
| Rpl15 | -2235.0 | 682.0 |
| Rpl18 | -2154.0 | 673.0 |
| Rpl18a | -4096.0 | 2967.0 |
| Rpl19 | -1550.0 | 1822.0 |
| Rpl22 | -2022.0 | -1577.0 |
| Rpl23 | -3192.0 | -63.0 |
| Rpl23a | -1746.0 | -1151.0 |
| Rpl24 | 1967.0 | -1516.0 |
| Rpl26 | -2917.0 | 1295.0 |
| Rpl27-ps3 | 997.5 | -4491.5 |
| Rpl27a | -740.0 | 3469.0 |
| Rpl28 | -3311.0 | 384.0 |
| Rpl29 | -1496.0 | 1580.0 |
| Rpl3 | -4399.0 | 641.0 |
| Rpl30 | -3898.0 | 753.0 |
| Rpl32 | -2024.0 | -114.0 |
| Rpl34 | -1828.0 | 264.0 |
| Rpl35 | -255.0 | 944.0 |
| Rpl36al | -378.0 | -968.0 |
| Rpl37 | -855.0 | -3821.0 |
| Rpl37a | -3905.0 | 4049.0 |
| Rpl38 | -3823.0 | 685.0 |
| Rpl39 | 1968.0 | -908.0 |
| Rpl3l | 3961.0 | -1994.0 |
| Rpl4 | -2331.0 | 1640.0 |
| Rpl41 | -550.0 | 688.0 |
| Rpl5 | -3992.0 | 3942.0 |
| Rpl6 | -3716.0 | 935.0 |
| Rpl8 | -3895.0 | 1539.0 |
| Rplp0 | -3918.0 | 1684.0 |
| Rplp1 | -388.0 | 3710.0 |
| Rplp2 | -3371.0 | 2764.0 |
| Rps11 | -2961.0 | 37.0 |
| Rps13 | -3562.0 | 3659.0 |
| Rps14 | -2630.0 | 4064.0 |
| Rps15a | -3210.0 | 2480.0 |
| Rps16 | -3737.0 | 417.0 |
| Rps17 | 718.0 | 3046.0 |
| Rps18 | -4174.0 | -2157.0 |
| Rps19 | -980.0 | 2899.0 |
| Rps20 | -3688.0 | 3874.0 |
| Rps21 | -161.0 | 1078.0 |
| Rps23 | -3757.0 | 817.0 |
| Rps24 | -3792.0 | 195.0 |
| Rps25 | -3437.0 | 1296.0 |
| Rps26 | -3327.0 | 3699.0 |
| Rps27 | -441.0 | 2984.0 |
| Rps27a | -405.0 | 3577.0 |
| Rps29 | 4565.0 | 1750.0 |
| Rps3 | -4328.0 | 558.0 |
| Rps3a1 | -3863.0 | 1143.0 |
| Rps4x | -4218.0 | 3694.0 |
| Rps5 | -2098.0 | 982.0 |
| Rps6 | -4242.0 | -1590.0 |
| Rps7 | -4205.0 | -2011.0 |
| Rps8 | -3862.0 | 2318.0 |
| Rps9 | -3991.0 | 1585.0 |
| Rpsa | -3512.0 | 3186.0 |
| Uba52 | 4493.0 | 4487.0 |
REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0365 |
| p.adjustMANOVA | 0.128 |
| s.dist | 0.463 |
| s.Sed | -0.375 |
| s.Ex | -0.273 |
| p.Sed | 0.0403 |
| p.Ex | 0.135 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb4 | -3440 | -4494 |
| Gnao1 | -2204 | -4216 |
| Gnb5 | -1086 | -4561 |
| Gnb1 | -763 | -1610 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adcy6 | 1437 | -528 |
| Gnai2 | -4237 | 2747 |
| Gnao1 | -2204 | -4216 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
| metric | value |
|---|---|
| setSize | 84 |
| pMANOVA | 1.6e-11 |
| p.adjustMANOVA | 1.05e-09 |
| s.dist | 0.451 |
| s.Sed | -0.407 |
| s.Ex | 0.194 |
| p.Sed | 1.28e-10 |
| p.Ex | 0.00213 |
| Gene | Sed | Ex |
|---|---|---|
| Rpl37a | -3905 | 4049 |
| Rpl5 | -3992 | 3942 |
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Rpl18a | -4096 | 2967 |
| Rpsa | -3512 | 3186 |
| Rps14 | -2630 | 4064 |
| Rplp2 | -3371 | 2764 |
| Rps8 | -3862 | 2318 |
| Rpl14 | -3324 | 2450 |
| Rps15a | -3210 | 2480 |
| Rplp0 | -3918 | 1684 |
| Smg8 | -2863 | 2289 |
| Rpl10a | -1820 | 3571 |
| Rps9 | -3991 | 1585 |
| Smg6 | -2069 | 3049 |
| Rpl8 | -3895 | 1539 |
| Rps25 | -3437 | 1296 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Casc3 | 2910.0 | 2633.0 |
| Eif4a3 | -3222.0 | 802.0 |
| Eif4g1 | 3040.0 | 596.0 |
| Etf1 | 3932.0 | -336.0 |
| Magoh | 1568.0 | -4286.0 |
| Ncbp1 | -838.0 | -446.0 |
| Ncbp2 | 3713.0 | -2399.0 |
| Ppp2ca | -2574.0 | -4423.0 |
| Ppp2r1a | 3371.0 | 793.0 |
| Ppp2r2a | -640.0 | 4024.0 |
| Rnps1 | -2837.0 | -3253.0 |
| Rpl10a | -1820.0 | 3571.0 |
| Rpl11 | -4233.0 | 1016.0 |
| Rpl12 | -4366.0 | 281.0 |
| Rpl13 | -2635.0 | 1005.0 |
| Rpl14 | -3324.0 | 2450.0 |
| Rpl15 | -2235.0 | 682.0 |
| Rpl18 | -2154.0 | 673.0 |
| Rpl18a | -4096.0 | 2967.0 |
| Rpl19 | -1550.0 | 1822.0 |
| Rpl22 | -2022.0 | -1577.0 |
| Rpl23 | -3192.0 | -63.0 |
| Rpl23a | -1746.0 | -1151.0 |
| Rpl24 | 1967.0 | -1516.0 |
| Rpl26 | -2917.0 | 1295.0 |
| Rpl27-ps3 | 997.5 | -4491.5 |
| Rpl27a | -740.0 | 3469.0 |
| Rpl28 | -3311.0 | 384.0 |
| Rpl29 | -1496.0 | 1580.0 |
| Rpl3 | -4399.0 | 641.0 |
| Rpl30 | -3898.0 | 753.0 |
| Rpl32 | -2024.0 | -114.0 |
| Rpl34 | -1828.0 | 264.0 |
| Rpl35 | -255.0 | 944.0 |
| Rpl36al | -378.0 | -968.0 |
| Rpl37 | -855.0 | -3821.0 |
| Rpl37a | -3905.0 | 4049.0 |
| Rpl38 | -3823.0 | 685.0 |
| Rpl39 | 1968.0 | -908.0 |
| Rpl3l | 3961.0 | -1994.0 |
| Rpl4 | -2331.0 | 1640.0 |
| Rpl41 | -550.0 | 688.0 |
| Rpl5 | -3992.0 | 3942.0 |
| Rpl6 | -3716.0 | 935.0 |
| Rpl8 | -3895.0 | 1539.0 |
| Rplp0 | -3918.0 | 1684.0 |
| Rplp1 | -388.0 | 3710.0 |
| Rplp2 | -3371.0 | 2764.0 |
| Rps11 | -2961.0 | 37.0 |
| Rps13 | -3562.0 | 3659.0 |
| Rps14 | -2630.0 | 4064.0 |
| Rps15a | -3210.0 | 2480.0 |
| Rps16 | -3737.0 | 417.0 |
| Rps17 | 718.0 | 3046.0 |
| Rps18 | -4174.0 | -2157.0 |
| Rps19 | -980.0 | 2899.0 |
| Rps20 | -3688.0 | 3874.0 |
| Rps21 | -161.0 | 1078.0 |
| Rps23 | -3757.0 | 817.0 |
| Rps24 | -3792.0 | 195.0 |
| Rps25 | -3437.0 | 1296.0 |
| Rps26 | -3327.0 | 3699.0 |
| Rps27 | -441.0 | 2984.0 |
| Rps27a | -405.0 | 3577.0 |
| Rps29 | 4565.0 | 1750.0 |
| Rps3 | -4328.0 | 558.0 |
| Rps3a1 | -3863.0 | 1143.0 |
| Rps4x | -4218.0 | 3694.0 |
| Rps5 | -2098.0 | 982.0 |
| Rps6 | -4242.0 | -1590.0 |
| Rps7 | -4205.0 | -2011.0 |
| Rps8 | -3862.0 | 2318.0 |
| Rps9 | -3991.0 | 1585.0 |
| Rpsa | -3512.0 | 3186.0 |
| Smg1 | -520.0 | -3241.0 |
| Smg5 | 4374.0 | 1345.0 |
| Smg6 | -2069.0 | 3049.0 |
| Smg7 | -3594.0 | -3059.0 |
| Smg8 | -2863.0 | 2289.0 |
| Smg9 | 3241.0 | -91.0 |
| Uba52 | 4493.0 | 4487.0 |
| Upf2 | -991.0 | 1628.0 |
| Upf3a | -2059.0 | 1869.0 |
| Upf3b | -3211.0 | 131.0 |
REACTOME_SIGNAL_AMPLIFICATION
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0126 |
| p.adjustMANOVA | 0.0606 |
| s.dist | 0.45 |
| s.Sed | -0.348 |
| s.Ex | -0.286 |
| p.Sed | 0.0243 |
| p.Ex | 0.0644 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb4 | -3440 | -4494 |
| P2ry1 | -3358 | -4086 |
| Gnb5 | -1086 | -4561 |
| Gnai3 | -2975 | -1402 |
| Mapk14 | -1671 | -1864 |
| Gnb1 | -763 | -1610 |
| Gnaq | -719 | -963 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gna11 | 1005 | -3655 |
| Gna13 | 2526 | 1340 |
| Gnai2 | -4237 | 2747 |
| Gnai3 | -2975 | -1402 |
| Gnaq | -719 | -963 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
| Mapk14 | -1671 | -1864 |
| P2ry1 | -3358 | -4086 |
REACTOME_TCR_SIGNALING
| metric | value |
|---|---|
| setSize | 28 |
| pMANOVA | 0.000232 |
| p.adjustMANOVA | 0.00353 |
| s.dist | 0.443 |
| s.Sed | -0.426 |
| s.Ex | -0.124 |
| p.Sed | 9.78e-05 |
| p.Ex | 0.256 |
| Gene | Sed | Ex |
|---|---|---|
| Pik3r1 | -3893 | -3036 |
| Nck1 | -3508 | -3039 |
| Pak2 | -3617 | -2547 |
| Rela | -2929 | -2946 |
| Pdpk1 | -1738 | -4479 |
| Pten | -1915 | -3552 |
| Plcg1 | -3840 | -1307 |
| Ikbkb | -3931 | -1132 |
| Nfkbia | -2039 | -1690 |
| Pik3ca | -518 | -3017 |
| Csk | -4434 | -100 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Bcl10 | -2949 | 2344 |
| Chuk | -1520 | 4219 |
| Csk | -4434 | -100 |
| Enah | 3225 | -3037 |
| Gm20431 | 944 | -3902 |
| H2-Aa | -4380 | 4605 |
| H2-Eb1 | -4401 | 4501 |
| Ikbkb | -3931 | -1132 |
| Ikbkg | 1260 | -718 |
| Malt1 | -2297 | 521 |
| Map3k7 | 1636 | -4248 |
| Nck1 | -3508 | -3039 |
| Nfkbia | -2039 | -1690 |
| Pak1 | -2087 | 232 |
| Pak2 | -3617 | -2547 |
| Pdpk1 | -1738 | -4479 |
| Pik3ca | -518 | -3017 |
| Pik3cb | 4032 | 3425 |
| Pik3r1 | -3893 | -3036 |
| Pik3r2 | 2211 | 733 |
| Plcg1 | -3840 | -1307 |
| Prkcq | 761 | -3068 |
| Pten | -1915 | -3552 |
| Ptprc | -4287 | 395 |
| Rela | -2929 | -2946 |
| Tab2 | -1690 | 433 |
| Traf6 | -3347 | 76 |
| Vasp | -4386 | 4173 |
REACTOME_STRIATED_MUSCLE_CONTRACTION
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 0.00217 |
| p.adjustMANOVA | 0.0165 |
| s.dist | 0.438 |
| s.Sed | 0.351 |
| s.Ex | -0.262 |
| p.Sed | 0.00442 |
| p.Ex | 0.0338 |
| Gene | Sed | Ex |
|---|---|---|
| Mybpc1 | 4817 | -4470 |
| Tpm2 | 3637 | -4628 |
| Tcap | 4710 | -3413 |
| Myl2 | 3179 | -4631 |
| Actn2 | 3712 | -3777 |
| Tnnt1 | 1951 | -4453 |
| Myl3 | 1869 | -4633 |
| Neb | 4018 | -1819 |
| Tmod1 | 2391 | -1631 |
| Des | 3367 | -1078 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Actn2 | 3712 | -3777 |
| Des | 3367 | -1078 |
| Dmd | 4608 | 398 |
| Mybpc1 | 4817 | -4470 |
| Mybpc2 | -701 | 3728 |
| Myl1 | 3543 | 3028 |
| Myl2 | 3179 | -4631 |
| Myl3 | 1869 | -4633 |
| Myl4 | 675 | 4433 |
| Neb | 4018 | -1819 |
| Tcap | 4710 | -3413 |
| Tmod1 | 2391 | -1631 |
| Tnnc1 | -479 | -4576 |
| Tnnc2 | 3051 | 3442 |
| Tnni1 | -164 | -3472 |
| Tnni2 | 3271 | 870 |
| Tnnt1 | 1951 | -4453 |
| Tpm1 | 2207 | 3840 |
| Tpm2 | 3637 | -4628 |
| Tpm3 | -2041 | -4399 |
| Tpm4 | -3450 | -1999 |
| Vim | -4322 | 2566 |
REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0123 |
| p.adjustMANOVA | 0.0596 |
| s.dist | 0.435 |
| s.Sed | 0.312 |
| s.Ex | -0.302 |
| p.Sed | 0.0306 |
| p.Ex | 0.0363 |
| Gene | Sed | Ex |
|---|---|---|
| Ivd | 4324 | -4120 |
| Acat1 | 3966 | -4436 |
| Hibch | 4231 | -3553 |
| Dbt | 3818 | -3788 |
| Hibadh | 3823 | -1755 |
| Aldh6a1 | 702 | -4610 |
| Bckdha | 1638 | -1613 |
| Dld | 4023 | -601 |
| Auh | 996 | -1126 |
| Hsd17b10 | 233 | -964 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Acad8 | 1728 | 3322 |
| Acadsb | 1092 | 3144 |
| Acat1 | 3966 | -4436 |
| Aldh6a1 | 702 | -4610 |
| Auh | 996 | -1126 |
| Bcat2 | -889 | -741 |
| Bckdha | 1638 | -1613 |
| Bckdhb | -3111 | -631 |
| Dbt | 3818 | -3788 |
| Dld | 4023 | -601 |
| Hibadh | 3823 | -1755 |
| Hibch | 4231 | -3553 |
| Hsd17b10 | 233 | -964 |
| Ivd | 4324 | -4120 |
| Mccc1 | 1479 | 3070 |
| Mccc2 | -1897 | -4034 |
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0223 |
| p.adjustMANOVA | 0.0919 |
| s.dist | 0.424 |
| s.Sed | -0.419 |
| s.Ex | -0.0637 |
| p.Sed | 0.00665 |
| p.Ex | 0.68 |
| Gene | Sed | Ex |
|---|---|---|
| Sec24d | -3639 | -3868 |
| Pdia3 | -3056 | -3982 |
| Canx | -3475 | -2410 |
| Tap2 | -4272 | -1557 |
| Hspa5 | -3671 | -519 |
| Sec24b | -544 | -1165 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| B2m | -4307 | 44 |
| Calr | -3917 | 1891 |
| Canx | -3475 | -2410 |
| Erap1 | -3001 | 3252 |
| Hspa5 | -3671 | -519 |
| Pdia3 | -3056 | -3982 |
| Sar1b | 1549 | 3179 |
| Sec13 | -400 | 134 |
| Sec23a | 4424 | -2035 |
| Sec24b | -544 | -1165 |
| Sec24c | 98 | 578 |
| Sec24d | -3639 | -3868 |
| Sec31a | -222 | 2273 |
| Tap2 | -4272 | -1557 |
REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
| metric | value |
|---|---|
| setSize | 85 |
| pMANOVA | 2.47e-10 |
| p.adjustMANOVA | 1.13e-08 |
| s.dist | 0.423 |
| s.Sed | -0.381 |
| s.Ex | 0.183 |
| p.Sed | 1.37e-09 |
| p.Ex | 0.00358 |
| Gene | Sed | Ex |
|---|---|---|
| Rpl37a | -3905 | 4049 |
| Rpl5 | -3992 | 3942 |
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Rpl18a | -4096 | 2967 |
| Rpsa | -3512 | 3186 |
| Rps14 | -2630 | 4064 |
| Rplp2 | -3371 | 2764 |
| Rps8 | -3862 | 2318 |
| Rpl14 | -3324 | 2450 |
| Rps15a | -3210 | 2480 |
| Rplp0 | -3918 | 1684 |
| Rpl10a | -1820 | 3571 |
| Rps9 | -3991 | 1585 |
| Rpl8 | -3895 | 1539 |
| Rps25 | -3437 | 1296 |
| Rps3a1 | -3863 | 1143 |
| Rpl11 | -4233 | 1016 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Eif1ax | -1582.0 | -3794.0 |
| Eif2s1 | 3422.0 | 2411.0 |
| Eif2s2 | 4151.0 | 2919.0 |
| Eif2s3x | -2356.0 | -702.0 |
| Eif3a | 3103.0 | -2833.0 |
| Eif3b | -2573.0 | 1653.0 |
| Eif3c | -346.0 | -432.0 |
| Eif3d | -798.0 | -442.0 |
| Eif3e | -1404.0 | -740.0 |
| Eif3f | -3081.0 | -1711.0 |
| Eif3g | -750.0 | 1101.0 |
| Eif3h | -2518.0 | -2879.0 |
| Eif3i | 2507.0 | 2009.0 |
| Eif3j2 | 1699.0 | -667.0 |
| Eif3k | -3262.0 | -2381.0 |
| Eif4a1 | 431.0 | 2385.0 |
| Eif4a2 | 788.0 | 1590.0 |
| Eif4b | 475.0 | -1280.0 |
| Eif4e | 4119.0 | -2550.0 |
| Eif4g1 | 3040.0 | 596.0 |
| Eif4h | 3996.0 | -102.0 |
| Rpl10a | -1820.0 | 3571.0 |
| Rpl11 | -4233.0 | 1016.0 |
| Rpl12 | -4366.0 | 281.0 |
| Rpl13 | -2635.0 | 1005.0 |
| Rpl14 | -3324.0 | 2450.0 |
| Rpl15 | -2235.0 | 682.0 |
| Rpl18 | -2154.0 | 673.0 |
| Rpl18a | -4096.0 | 2967.0 |
| Rpl19 | -1550.0 | 1822.0 |
| Rpl22 | -2022.0 | -1577.0 |
| Rpl23 | -3192.0 | -63.0 |
| Rpl23a | -1746.0 | -1151.0 |
| Rpl24 | 1967.0 | -1516.0 |
| Rpl26 | -2917.0 | 1295.0 |
| Rpl27-ps3 | 997.5 | -4491.5 |
| Rpl27a | -740.0 | 3469.0 |
| Rpl28 | -3311.0 | 384.0 |
| Rpl29 | -1496.0 | 1580.0 |
| Rpl3 | -4399.0 | 641.0 |
| Rpl30 | -3898.0 | 753.0 |
| Rpl32 | -2024.0 | -114.0 |
| Rpl34 | -1828.0 | 264.0 |
| Rpl35 | -255.0 | 944.0 |
| Rpl36al | -378.0 | -968.0 |
| Rpl37 | -855.0 | -3821.0 |
| Rpl37a | -3905.0 | 4049.0 |
| Rpl38 | -3823.0 | 685.0 |
| Rpl39 | 1968.0 | -908.0 |
| Rpl3l | 3961.0 | -1994.0 |
| Rpl4 | -2331.0 | 1640.0 |
| Rpl41 | -550.0 | 688.0 |
| Rpl5 | -3992.0 | 3942.0 |
| Rpl6 | -3716.0 | 935.0 |
| Rpl8 | -3895.0 | 1539.0 |
| Rplp0 | -3918.0 | 1684.0 |
| Rplp1 | -388.0 | 3710.0 |
| Rplp2 | -3371.0 | 2764.0 |
| Rps11 | -2961.0 | 37.0 |
| Rps13 | -3562.0 | 3659.0 |
| Rps14 | -2630.0 | 4064.0 |
| Rps15a | -3210.0 | 2480.0 |
| Rps16 | -3737.0 | 417.0 |
| Rps17 | 718.0 | 3046.0 |
| Rps18 | -4174.0 | -2157.0 |
| Rps19 | -980.0 | 2899.0 |
| Rps20 | -3688.0 | 3874.0 |
| Rps21 | -161.0 | 1078.0 |
| Rps23 | -3757.0 | 817.0 |
| Rps24 | -3792.0 | 195.0 |
| Rps25 | -3437.0 | 1296.0 |
| Rps26 | -3327.0 | 3699.0 |
| Rps27 | -441.0 | 2984.0 |
| Rps27a | -405.0 | 3577.0 |
| Rps29 | 4565.0 | 1750.0 |
| Rps3 | -4328.0 | 558.0 |
| Rps3a1 | -3863.0 | 1143.0 |
| Rps4x | -4218.0 | 3694.0 |
| Rps5 | -2098.0 | 982.0 |
| Rps6 | -4242.0 | -1590.0 |
| Rps7 | -4205.0 | -2011.0 |
| Rps8 | -3862.0 | 2318.0 |
| Rps9 | -3991.0 | 1585.0 |
| Rpsa | -3512.0 | 3186.0 |
| Uba52 | 4493.0 | 4487.0 |
REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0822 |
| p.adjustMANOVA | 0.213 |
| s.dist | 0.414 |
| s.Sed | -0.341 |
| s.Ex | 0.235 |
| p.Sed | 0.0621 |
| p.Ex | 0.199 |
| Gene | Sed | Ex |
|---|---|---|
| Apex1 | -3885 | 3120 |
| Pold1 | -4294 | 2494 |
| Pold3 | -3598 | 2190 |
| Mpg | -2758 | 2582 |
| Pold4 | -2369 | 2041 |
| Pcna | -2359 | 1282 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Apex1 | -3885 | 3120 |
| Mpg | -2758 | 2582 |
| Pcna | -2359 | 1282 |
| Polb | 4513 | -2567 |
| Pold1 | -4294 | 2494 |
| Pold2 | 2846 | -572 |
| Pold3 | -3598 | 2190 |
| Pold4 | -2369 | 2041 |
| Smug1 | 1758 | 3503 |
| Tdg | -3698 | -3260 |
REACTOME_GLUTATHIONE_CONJUGATION
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0564 |
| p.adjustMANOVA | 0.182 |
| s.dist | 0.405 |
| s.Sed | 0.357 |
| s.Ex | -0.19 |
| p.Sed | 0.0321 |
| p.Ex | 0.256 |
| Gene | Sed | Ex |
|---|---|---|
| Gsto1 | 4054 | -3425 |
| Gstm4 | 3623 | -3650 |
| Mgst1 | 2866 | -4042 |
| Oplah | 2105 | -3956 |
| Mgst3 | 3500 | -2067 |
| Gss | 4301 | -1564 |
| Ggct | 2064 | -1274 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Cndp2 | -1456 | -246 |
| Gclc | -3500 | 2708 |
| Gclm | 3413 | 3579 |
| Ggct | 2064 | -1274 |
| Gss | 4301 | -1564 |
| Gstm2 | -1207 | 354 |
| Gstm4 | 3623 | -3650 |
| Gsto1 | 4054 | -3425 |
| Gstp1 | 2364 | 3009 |
| Mgst1 | 2866 | -4042 |
| Mgst3 | 3500 | -2067 |
| Oplah | 2105 | -3956 |
REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.1 |
| p.adjustMANOVA | 0.241 |
| s.dist | 0.394 |
| s.Sed | 0.389 |
| s.Ex | -0.0575 |
| p.Sed | 0.0331 |
| p.Ex | 0.753 |
| Gene | Sed | Ex |
|---|---|---|
| Kcnc1 | 4426 | -3937 |
| Kcna7 | 4717 | -3286 |
| Kcnq5 | 1713 | -4356 |
| Kcnq4 | 2465 | -1665 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Kcna7 | 4717 | -3286 |
| Kcnab1 | -269 | 4438 |
| Kcnb1 | -569 | -3560 |
| Kcnc1 | 4426 | -3937 |
| Kcnc3 | -339 | -1057 |
| Kcnc4 | 2405 | 3563 |
| Kcnf1 | 3578 | 4589 |
| Kcng4 | 1789 | 2567 |
| Kcnq4 | 2465 | -1665 |
| Kcnq5 | 1713 | -4356 |
REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.0144 |
| p.adjustMANOVA | 0.0657 |
| s.dist | 0.392 |
| s.Sed | -0.359 |
| s.Ex | -0.158 |
| p.Sed | 0.00833 |
| p.Ex | 0.247 |
| Gene | Sed | Ex |
|---|---|---|
| Tnrc6c | -3631 | -4107 |
| E2f3 | -3576 | -4007 |
| Notch4 | -3632 | -3316 |
| Notch3 | -3341 | -3410 |
| Tnrc6a | -2707 | -3203 |
| Snw1 | -2821 | -1118 |
| Crebbp | -975 | -2795 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Ccnd1 | -3922 | 747 |
| Crebbp | -975 | -2795 |
| E2f3 | -3576 | -4007 |
| Ep300 | 586 | -3268 |
| Jun | 2796 | -3836 |
| Kat2a | -2011 | 3201 |
| Kat2b | 3145 | 617 |
| Maml1 | 1177 | 2625 |
| Notch2 | -3892 | 3451 |
| Notch3 | -3341 | -3410 |
| Notch4 | -3632 | -3316 |
| Rbpj | -337 | 841 |
| Snw1 | -2821 | -1118 |
| Tfdp1 | -634 | 2720 |
| Tnrc6a | -2707 | -3203 |
| Tnrc6b | 27 | 1146 |
| Tnrc6c | -3631 | -4107 |
| Trp53 | -2688 | 523 |
REACTOME_INFLUENZA_LIFE_CYCLE
| metric | value |
|---|---|
| setSize | 113 |
| pMANOVA | 2.35e-11 |
| p.adjustMANOVA | 1.34e-09 |
| s.dist | 0.387 |
| s.Sed | -0.331 |
| s.Ex | 0.201 |
| p.Sed | 1.39e-09 |
| p.Ex | 0.000243 |
| Gene | Sed | Ex |
|---|---|---|
| Rpl37a | -3905 | 4049 |
| Rpl5 | -3992 | 3942 |
| Rps4x | -4218 | 3694 |
| Rps20 | -3688 | 3874 |
| Rps13 | -3562 | 3659 |
| Rps26 | -3327 | 3699 |
| Rpl18a | -4096 | 2967 |
| Rpsa | -3512 | 3186 |
| Rae1 | -3082 | 3604 |
| Rps14 | -2630 | 4064 |
| Polr2a | -3855 | 2581 |
| Rplp2 | -3371 | 2764 |
| Rps8 | -3862 | 2318 |
| Rpl14 | -3324 | 2450 |
| Rps15a | -3210 | 2480 |
| Nup85 | -1720 | 4367 |
| Calr | -3917 | 1891 |
| Nup43 | -1940 | 3720 |
| Rplp0 | -3918 | 1684 |
| Rpl10a | -1820 | 3571 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Calr | -3917.0 | 1891.0 |
| Canx | -3475.0 | -2410.0 |
| Clta | -1071.0 | 3072.0 |
| Cltc | -328.0 | 1695.0 |
| Dnajc3 | 820.0 | 156.0 |
| Grsf1 | 4037.0 | -4249.0 |
| Gtf2f1 | 433.0 | 1152.0 |
| Gtf2f2 | -2108.0 | 2244.0 |
| Hsp90aa1 | 2556.0 | -4071.0 |
| Hspa1b | 3993.0 | -3818.0 |
| Ipo5 | 1761.0 | -2131.0 |
| Kpna1 | 1548.0 | 2894.0 |
| Kpnb1 | -1661.0 | 2964.0 |
| Nup107 | -2461.0 | 1815.0 |
| Nup133 | -2815.0 | 441.0 |
| Nup153 | -463.0 | -2958.0 |
| Nup155 | -2112.0 | -241.0 |
| Nup188 | -260.0 | 2455.0 |
| Nup205 | -1565.0 | 1387.0 |
| Nup210 | 77.0 | 182.0 |
| Nup214 | 858.0 | -373.0 |
| Nup35 | 1071.0 | -287.0 |
| Nup37 | 2614.0 | 1375.0 |
| Nup43 | -1940.0 | 3720.0 |
| Nup54 | -2606.0 | -3183.0 |
| Nup62 | 2772.0 | 3349.0 |
| Nup85 | -1720.0 | 4367.0 |
| Nup88 | -1021.0 | 937.0 |
| Nup93 | -793.0 | 4409.0 |
| Nupl2 | 3262.0 | 589.0 |
| Polr2a | -3855.0 | 2581.0 |
| Polr2b | -2692.0 | -708.0 |
| Polr2c | -822.0 | -1229.0 |
| Polr2d | 2414.0 | 2119.0 |
| Polr2e | -2634.0 | -284.0 |
| Polr2f | -2832.0 | -1959.0 |
| Polr2g | -3118.0 | 1690.0 |
| Polr2h | -3127.0 | -2058.0 |
| Polr2i | 2901.0 | -2456.0 |
| Polr2j | -2391.0 | -1032.0 |
| Polr2k | 3087.0 | -1180.0 |
| Polr2l | 1477.0 | 4132.0 |
| Pom121 | 3596.0 | 85.0 |
| Rae1 | -3082.0 | 3604.0 |
| Ran | -1376.0 | 2014.0 |
| Ranbp2 | 2885.0 | 764.0 |
| Rpl10a | -1820.0 | 3571.0 |
| Rpl11 | -4233.0 | 1016.0 |
| Rpl12 | -4366.0 | 281.0 |
| Rpl13 | -2635.0 | 1005.0 |
| Rpl14 | -3324.0 | 2450.0 |
| Rpl15 | -2235.0 | 682.0 |
| Rpl18 | -2154.0 | 673.0 |
| Rpl18a | -4096.0 | 2967.0 |
| Rpl19 | -1550.0 | 1822.0 |
| Rpl22 | -2022.0 | -1577.0 |
| Rpl23 | -3192.0 | -63.0 |
| Rpl23a | -1746.0 | -1151.0 |
| Rpl24 | 1967.0 | -1516.0 |
| Rpl26 | -2917.0 | 1295.0 |
| Rpl27-ps3 | 997.5 | -4491.5 |
| Rpl27a | -740.0 | 3469.0 |
| Rpl28 | -3311.0 | 384.0 |
| Rpl29 | -1496.0 | 1580.0 |
| Rpl3 | -4399.0 | 641.0 |
| Rpl30 | -3898.0 | 753.0 |
| Rpl32 | -2024.0 | -114.0 |
| Rpl34 | -1828.0 | 264.0 |
| Rpl35 | -255.0 | 944.0 |
| Rpl36al | -378.0 | -968.0 |
| Rpl37 | -855.0 | -3821.0 |
| Rpl37a | -3905.0 | 4049.0 |
| Rpl38 | -3823.0 | 685.0 |
| Rpl39 | 1968.0 | -908.0 |
| Rpl3l | 3961.0 | -1994.0 |
| Rpl4 | -2331.0 | 1640.0 |
| Rpl41 | -550.0 | 688.0 |
| Rpl5 | -3992.0 | 3942.0 |
| Rpl6 | -3716.0 | 935.0 |
| Rpl8 | -3895.0 | 1539.0 |
| Rplp0 | -3918.0 | 1684.0 |
| Rplp1 | -388.0 | 3710.0 |
| Rplp2 | -3371.0 | 2764.0 |
| Rps11 | -2961.0 | 37.0 |
| Rps13 | -3562.0 | 3659.0 |
| Rps14 | -2630.0 | 4064.0 |
| Rps15a | -3210.0 | 2480.0 |
| Rps16 | -3737.0 | 417.0 |
| Rps17 | 718.0 | 3046.0 |
| Rps18 | -4174.0 | -2157.0 |
| Rps19 | -980.0 | 2899.0 |
| Rps20 | -3688.0 | 3874.0 |
| Rps21 | -161.0 | 1078.0 |
| Rps23 | -3757.0 | 817.0 |
| Rps24 | -3792.0 | 195.0 |
| Rps25 | -3437.0 | 1296.0 |
| Rps26 | -3327.0 | 3699.0 |
| Rps27 | -441.0 | 2984.0 |
| Rps27a | -405.0 | 3577.0 |
| Rps29 | 4565.0 | 1750.0 |
| Rps3 | -4328.0 | 558.0 |
| Rps3a1 | -3863.0 | 1143.0 |
| Rps4x | -4218.0 | 3694.0 |
| Rps5 | -2098.0 | 982.0 |
| Rps6 | -4242.0 | -1590.0 |
| Rps7 | -4205.0 | -2011.0 |
| Rps8 | -3862.0 | 2318.0 |
| Rps9 | -3991.0 | 1585.0 |
| Rpsa | -3512.0 | 3186.0 |
| Seh1l | 4084.0 | 2854.0 |
| Tpr | 2551.0 | -101.0 |
| Uba52 | 4493.0 | 4487.0 |
| Xpo1 | -511.0 | -17.0 |
REACTOME_BASE_EXCISION_REPAIR
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0775 |
| p.adjustMANOVA | 0.21 |
| s.dist | 0.381 |
| s.Sed | -0.346 |
| s.Ex | 0.159 |
| p.Sed | 0.0378 |
| p.Ex | 0.339 |
| Gene | Sed | Ex |
|---|---|---|
| Apex1 | -3885 | 3120 |
| Pold1 | -4294 | 2494 |
| Pold3 | -3598 | 2190 |
| Mpg | -2758 | 2582 |
| Pold4 | -2369 | 2041 |
| Pcna | -2359 | 1282 |
| Xrcc1 | -1987 | 1422 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Apex1 | -3885 | 3120 |
| Lig3 | -1085 | -3448 |
| Mpg | -2758 | 2582 |
| Pcna | -2359 | 1282 |
| Polb | 4513 | -2567 |
| Pold1 | -4294 | 2494 |
| Pold2 | 2846 | -572 |
| Pold3 | -3598 | 2190 |
| Pold4 | -2369 | 2041 |
| Smug1 | 1758 | 3503 |
| Tdg | -3698 | -3260 |
| Xrcc1 | -1987 | 1422 |
REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.0235 |
| p.adjustMANOVA | 0.0933 |
| s.dist | 0.378 |
| s.Sed | 0.314 |
| s.Ex | -0.211 |
| p.Sed | 0.0212 |
| p.Ex | 0.122 |
| Gene | Sed | Ex |
|---|---|---|
| Slc25a20 | 4547 | -4271 |
| Acsl1 | 4275 | -4509 |
| Cpt1b | 2789 | -4606 |
| Stradb | 2780 | -3476 |
| Cpt2 | 3977 | -2125 |
| Acacb | 1847 | -2450 |
| Prkag2 | 567 | -4239 |
| Cab39 | 4401 | -511 |
| Prkaa2 | 3807 | -450 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Acacb | 1847 | -2450 |
| Acsl1 | 4275 | -4509 |
| Cab39 | 4401 | -511 |
| Cab39l | 1421 | 92 |
| Cpt1a | -2162 | 569 |
| Cpt1b | 2789 | -4606 |
| Cpt2 | 3977 | -2125 |
| Prkaa1 | 159 | 1629 |
| Prkaa2 | 3807 | -450 |
| Prkab1 | -3742 | -4535 |
| Prkab2 | 2749 | 2414 |
| Prkag1 | -1161 | 546 |
| Prkag2 | 567 | -4239 |
| Prkag3 | -1992 | 4327 |
| Slc25a20 | 4547 | -4271 |
| Stk11 | 2379 | 1276 |
| Strada | 2905 | 2710 |
| Stradb | 2780 | -3476 |
REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0574 |
| p.adjustMANOVA | 0.182 |
| s.dist | 0.378 |
| s.Sed | -0.315 |
| s.Ex | -0.209 |
| p.Sed | 0.0494 |
| p.Ex | 0.192 |
| Gene | Sed | Ex |
|---|---|---|
| Rela | -2929 | -2946 |
| Map3k1 | -4003 | -1333 |
| Ikbkb | -3931 | -1132 |
| Nfkbia | -2039 | -1690 |
| Nfkb2 | -860 | -3506 |
| Trim25 | -972 | -2030 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| App | -2516 | 816 |
| Chuk | -1520 | 4219 |
| Ikbkb | -3931 | -1132 |
| Ikbkg | 1260 | -718 |
| Map3k1 | -4003 | -1333 |
| Mavs | 3824 | -3416 |
| Nfkb2 | -860 | -3506 |
| Nfkbia | -2039 | -1690 |
| Nfkbib | -445 | 1487 |
| Rela | -2929 | -2946 |
| Traf2 | 1048 | -2451 |
| Traf6 | -3347 | 76 |
| Trim25 | -972 | -2030 |
REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0702 |
| p.adjustMANOVA | 0.201 |
| s.dist | 0.374 |
| s.Sed | -0.227 |
| s.Ex | 0.298 |
| p.Sed | 0.157 |
| p.Ex | 0.0629 |
| Gene | Sed | Ex |
|---|---|---|
| Tubb2a | -3731 | 3520 |
| Cct7 | -1881 | 2889 |
| Cct5 | -1218 | 2840 |
| Cct8 | -1874 | 1242 |
| Tcp1 | -1039 | 1460 |
| Cct3 | -602 | 962 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Cct2 | -3235 | -4135 |
| Cct3 | -602 | 962 |
| Cct4 | -1684 | -353 |
| Cct5 | -1218 | 2840 |
| Cct7 | -1881 | 2889 |
| Cct8 | -1874 | 1242 |
| Tcp1 | -1039 | 1460 |
| Tuba1a | 1690 | 2016 |
| Tuba1b | -4012 | -2043 |
| Tuba4a | 2035 | 3073 |
| Tubb2a | -3731 | 3520 |
| Tubb4b | 3975 | 4301 |
| Tubb6 | 444 | 2078 |
REACTOME_RAP1_SIGNALLING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0829 |
| p.adjustMANOVA | 0.213 |
| s.dist | 0.372 |
| s.Sed | -0.372 |
| s.Ex | -0.00799 |
| p.Sed | 0.0258 |
| p.Ex | 0.962 |
| Gene | Sed | Ex |
|---|---|---|
| Rap1gap | -2729 | -3079 |
| Rapgef3 | -2174 | -1853 |
| Rasgrp2 | -4360 | -733 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Prkaca | 1010 | -2905 |
| Prkacb | -4104 | 545 |
| Prkg1 | 4738 | -4380 |
| Raf1 | 4047 | 1767 |
| Rap1a | -813 | 783 |
| Rap1b | -3629 | 3359 |
| Rap1gap | -2729 | -3079 |
| Rap1gap2 | -1864 | 4325 |
| Rapgef3 | -2174 | -1853 |
| Rasgrp2 | -4360 | -733 |
| Sipa1 | -4113 | 1204 |
| Ywhab | -4334 | 470 |
REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
| metric | value |
|---|---|
| setSize | 42 |
| pMANOVA | 0.000229 |
| p.adjustMANOVA | 0.00353 |
| s.dist | 0.37 |
| s.Sed | 0.326 |
| s.Ex | -0.175 |
| p.Sed | 0.000264 |
| p.Ex | 0.0496 |
| Gene | Sed | Ex |
|---|---|---|
| Timm8a1 | 3995 | -4605 |
| Timm17a | 4538 | -3445 |
| Tomm5 | 4312 | -2590 |
| Slc25a12 | 2630 | -3646 |
| Hspa9 | 3438 | -2272 |
| Hspd1 | 1476 | -4332 |
| Timm44 | 2857 | -2182 |
| Timm50 | 1652 | -3633 |
| Cs | 1819 | -3152 |
| Vdac1 | 3661 | -1399 |
| Tomm20 | 2240 | -1936 |
| Idh3g | 2624 | -1177 |
| Pmpca | 1438 | -1902 |
| Ldhd | 641 | -3817 |
| Slc25a4 | 4299 | -469 |
| Atp5g1 | 3844 | -451 |
| Grpel1 | 1373 | -217 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 3944 | 553 |
| Atp5a1 | 2863 | 945 |
| Atp5b | 3950 | 766 |
| Atp5g1 | 3844 | -451 |
| Bcs1l | -1850 | -1115 |
| Coq2 | -1767 | 1007 |
| Cs | 1819 | -3152 |
| Cyc1 | 1453 | 2753 |
| Dnajc19 | 906 | 1561 |
| Fxn | -4100 | -2601 |
| Gfer | 4779 | 197 |
| Grpel1 | 1373 | -217 |
| Grpel2 | 4678 | 1348 |
| Hscb | -537 | -4534 |
| Hspa9 | 3438 | -2272 |
| Hspd1 | 1476 | -4332 |
| Idh3g | 2624 | -1177 |
| Ldhd | 641 | -3817 |
| Mtx1 | -989 | 19 |
| Mtx2 | 2334 | 54 |
| Pmpca | 1438 | -1902 |
| Pmpcb | 2569 | 3035 |
| Samm50 | 3539 | 3259 |
| Slc25a12 | 2630 | -3646 |
| Slc25a4 | 4299 | -469 |
| Timm10 | -1805 | -4112 |
| Timm13 | -1751 | 1521 |
| Timm17a | 4538 | -3445 |
| Timm17b | -2850 | 1378 |
| Timm22 | 827 | 392 |
| Timm23 | 3113 | 4070 |
| Timm44 | 2857 | -2182 |
| Timm50 | 1652 | -3633 |
| Timm8a1 | 3995 | -4605 |
| Timm8b | -3760 | -4483 |
| Timm9 | -1291 | -1863 |
| Tomm20 | 2240 | -1936 |
| Tomm22 | 3923 | 1505 |
| Tomm40 | 1285 | 1205 |
| Tomm5 | 4312 | -2590 |
| Tomm7 | 4768 | 244 |
| Vdac1 | 3661 | -1399 |
REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC
| metric | value |
|---|---|
| setSize | 43 |
| pMANOVA | 0.000126 |
| p.adjustMANOVA | 0.00222 |
| s.dist | 0.368 |
| s.Sed | 0.277 |
| s.Ex | 0.242 |
| p.Sed | 0.00166 |
| p.Ex | 0.00602 |
| Gene | Sed | Ex |
|---|---|---|
| Psmc3 | 4043 | 4412 |
| Odc1 | 4483 | 3897 |
| Oaz1 | 3544 | 3218 |
| Psmd8 | 2925 | 3846 |
| Psmd7 | 2763 | 3966 |
| Psmd14 | 3743 | 2751 |
| Psmd12 | 4534 | 2238 |
| Psmf1 | 1960 | 4419 |
| Psmb5 | 2531 | 3233 |
| Psme4 | 2895 | 2464 |
| Psmd1 | 2083 | 3084 |
| Psma3 | 3334 | 1849 |
| Psmd6 | 2457 | 2159 |
| Psmc1 | 1825 | 2519 |
| Psmb7 | 4039 | 1027 |
| Psmd5 | 3517 | 1017 |
| Psmb6 | 1292 | 2733 |
| Psmd4 | 1315 | 2386 |
| Nqo1 | 735 | 4194 |
| Psmd3 | 1457 | 1377 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Azin1 | 4497 | -1303 |
| Nqo1 | 735 | 4194 |
| Oaz1 | 3544 | 3218 |
| Oaz2 | 3949 | -3149 |
| Odc1 | 4483 | 3897 |
| Psma1 | -355 | -937 |
| Psma2 | 2956 | -3526 |
| Psma3 | 3334 | 1849 |
| Psma4 | -594 | 2849 |
| Psma5 | -986 | 2233 |
| Psma6 | 327 | -773 |
| Psma7 | 443 | -2813 |
| Psmb1 | -418 | 878 |
| Psmb10 | -768 | -1686 |
| Psmb2 | -2028 | 794 |
| Psmb3 | 2776 | -2638 |
| Psmb4 | 162 | -1714 |
| Psmb5 | 2531 | 3233 |
| Psmb6 | 1292 | 2733 |
| Psmb7 | 4039 | 1027 |
| Psmc1 | 1825 | 2519 |
| Psmc2 | -234 | 363 |
| Psmc3 | 4043 | 4412 |
| Psmc4 | 587 | 1675 |
| Psmc5 | 67 | 4343 |
| Psmc6 | -1202 | -2652 |
| Psmd1 | 2083 | 3084 |
| Psmd10 | -3724 | 388 |
| Psmd11 | 3384 | -2530 |
| Psmd12 | 4534 | 2238 |
| Psmd13 | 378 | 4002 |
| Psmd14 | 3743 | 2751 |
| Psmd2 | 1317 | 597 |
| Psmd3 | 1457 | 1377 |
| Psmd4 | 1315 | 2386 |
| Psmd5 | 3517 | 1017 |
| Psmd6 | 2457 | 2159 |
| Psmd7 | 2763 | 3966 |
| Psmd8 | 2925 | 3846 |
| Psmd9 | 959 | 509 |
| Psme1 | -3764 | -3872 |
| Psme4 | 2895 | 2464 |
| Psmf1 | 1960 | 4419 |
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.0288 |
| p.adjustMANOVA | 0.108 |
| s.dist | 0.368 |
| s.Sed | -0.297 |
| s.Ex | -0.217 |
| p.Sed | 0.034 |
| p.Ex | 0.121 |
| Gene | Sed | Ex |
|---|---|---|
| Akt1 | -3296 | -2715 |
| Pdpk1 | -1738 | -4479 |
| Grb2 | -3740 | -2002 |
| Vwf | -2747 | -2699 |
| Tln1 | -1603 | -2704 |
| Rapgef3 | -2174 | -1853 |
| Rasgrp2 | -4360 | -733 |
| Csk | -4434 | -100 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3296 | -2715 |
| Bcar1 | 4203 | 2572 |
| Crk | 2827 | -1194 |
| Csk | -4434 | -100 |
| Fn1 | 3301 | -2223 |
| Grb2 | -3740 | -2002 |
| Pdpk1 | -1738 | -4479 |
| Ptk2 | 3456 | -1465 |
| Ptpn1 | -3673 | 1735 |
| Rap1a | -813 | 783 |
| Rap1b | -3629 | 3359 |
| Rapgef3 | -2174 | -1853 |
| Rasgrp2 | -4360 | -733 |
| Shc1 | -2560 | 689 |
| Sos1 | 893 | -4117 |
| Tln1 | -1603 | -2704 |
| Vwf | -2747 | -2699 |
REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.13 |
| p.adjustMANOVA | 0.291 |
| s.dist | 0.364 |
| s.Sed | -0.206 |
| s.Ex | -0.3 |
| p.Sed | 0.261 |
| p.Ex | 0.1 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gnb1 | -763 | -1610 |
| Gnaq | -719 | -963 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gna11 | 1005 | -3655 |
| Gna13 | 2526 | 1340 |
| Gnaq | -719 | -963 |
| Gnb1 | -763 | -1610 |
| Gnb2 | -2285 | 297 |
| Gnb4 | -3440 | -4494 |
| Gnb5 | -1086 | -4561 |
| Gng11 | -1300 | 704 |
| Gng12 | -2757 | 2876 |
| Gng5 | 1229 | -3874 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] plyr_1.8.7 pkgload_1.3.0
## [3] GGally_2.1.2 gtools_3.9.2.2
## [5] echarts4r_0.4.4 beeswarm_0.4.0
## [7] vioplot_0.3.7 sm_2.2-5.7
## [9] kableExtra_1.3.4 topconfects_1.12.0
## [11] limma_3.52.1 eulerr_6.1.1
## [13] mitch_1.8.0 MASS_7.3-58
## [15] fgsea_1.22.0 gplots_3.1.3
## [17] DESeq2_1.36.0 SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0 MatrixGenerics_1.8.0
## [21] matrixStats_0.62.0 GenomicRanges_1.48.0
## [23] GenomeInfoDb_1.32.2 IRanges_2.30.0
## [25] S4Vectors_0.34.0 BiocGenerics_0.42.0
## [27] reshape2_1.4.4 forcats_0.5.1
## [29] stringr_1.4.0 dplyr_1.0.9
## [31] purrr_0.3.4 readr_2.1.2
## [33] tidyr_1.2.0 tibble_3.1.7
## [35] ggplot2_3.3.6 tidyverse_1.3.1
## [37] zoo_1.8-10
##
## loaded via a namespace (and not attached):
## [1] readxl_1.4.0 backports_1.4.1 fastmatch_1.1-3
## [4] systemfonts_1.0.4 splines_4.2.1 BiocParallel_1.30.3
## [7] digest_0.6.29 htmltools_0.5.2 fansi_1.0.3
## [10] magrittr_2.0.3 memoise_2.0.1 tzdb_0.3.0
## [13] Biostrings_2.64.0 annotate_1.74.0 modelr_0.1.8
## [16] svglite_2.1.0 prettyunits_1.1.1 colorspace_2.0-3
## [19] blob_1.2.3 rvest_1.0.2 haven_2.5.0
## [22] xfun_0.31 crayon_1.5.1 RCurl_1.98-1.7
## [25] jsonlite_1.8.0 genefilter_1.78.0 survival_3.4-0
## [28] glue_1.6.2 gtable_0.3.0 zlibbioc_1.42.0
## [31] XVector_0.36.0 webshot_0.5.3 DelayedArray_0.22.0
## [34] scales_1.2.0 DBI_1.1.3 Rcpp_1.0.8.3
## [37] viridisLite_0.4.0 xtable_1.8-4 progress_1.2.2
## [40] bit_4.0.4 htmlwidgets_1.5.4 httr_1.4.3
## [43] RColorBrewer_1.1-3 ellipsis_0.3.2 pkgconfig_2.0.3
## [46] reshape_0.8.9 XML_3.99-0.10 farver_2.1.0
## [49] sass_0.4.1 dbplyr_2.2.1 locfit_1.5-9.5
## [52] utf8_1.2.2 tidyselect_1.1.2 labeling_0.4.2
## [55] rlang_1.0.3 later_1.3.0 AnnotationDbi_1.58.0
## [58] munsell_0.5.0 cellranger_1.1.0 tools_4.2.1
## [61] cachem_1.0.6 cli_3.3.0 generics_0.1.2
## [64] RSQLite_2.2.14 broom_0.8.0 evaluate_0.15
## [67] fastmap_1.1.0 yaml_2.3.5 knitr_1.39
## [70] bit64_4.0.5 fs_1.5.2 caTools_1.18.2
## [73] KEGGREST_1.36.2 mime_0.12 xml2_1.3.3
## [76] compiler_4.2.1 rstudioapi_0.13 png_0.1-7
## [79] reprex_2.0.1 geneplotter_1.74.0 bslib_0.3.1
## [82] stringi_1.7.6 highr_0.9 lattice_0.20-45
## [85] Matrix_1.4-1 vctrs_0.4.1 pillar_1.7.0
## [88] lifecycle_1.0.1 jquerylib_0.1.4 data.table_1.14.2
## [91] bitops_1.0-7 httpuv_1.6.5 R6_2.5.1
## [94] promises_1.2.0.1 KernSmooth_2.23-20 gridExtra_2.3
## [97] codetools_0.2-18 assertthat_0.2.1 withr_2.5.0
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1 hms_1.1.1
## [103] grid_4.2.1 rmarkdown_2.14 shiny_1.7.1
## [106] lubridate_1.8.0END of report