Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-09-07
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## Sed Ex
## 0610009B22Rik -0.68382677 -0.5935749
## 0610009L18Rik 0.56527326 0.2161104
## 0610010K14Rik 0.66424429 -0.1134635
## 0610012G03Rik -0.18505314 -0.3269221
## 0610030E20Rik -0.38884282 -0.0645616
## 0610040J01Rik 0.04555983 -1.2938364| Profile metrics | |
|---|---|
| num_genes_in_profile | 9164 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 2714 |
| num_profile_genes_not_in_sets | 6450 |
| profile_pearson_correl | 0.0771 |
| profile_spearman_correl | 0.0351 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 674 |
| num_genesets_excluded | 219 |
| num_genesets_included | 455 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 30 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.Sed | s.Ex | p.Sed | p.Ex |
|---|---|---|---|---|---|---|---|---|
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 1.23e-10 | 8.01e-09 | 1.110 | 0.55500 | -0.9590 | 8.73e-04 | 8.71e-09 |
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 5.10e-13 | 4.64e-11 | 0.983 | 0.39100 | -0.9020 | 3.15e-03 | 9.83e-12 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 1.01e-31 | 1.54e-29 | 0.893 | 0.11800 | -0.8850 | 1.16e-01 | 4.99e-32 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 1.81e-38 | 4.12e-36 | 0.883 | 0.18900 | -0.8630 | 5.33e-03 | 2.31e-37 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 3.05e-52 | 1.39e-49 | 0.852 | 0.20300 | -0.8270 | 2.97e-04 | 1.04e-49 |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 2.72e-06 | 1.24e-04 | 0.801 | 0.29300 | -0.7450 | 6.77e-02 | 3.27e-06 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 6.77e-17 | 7.70e-15 | 0.800 | 0.25000 | -0.7600 | 7.82e-03 | 5.17e-16 |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 7.58e-05 | 2.15e-03 | 0.771 | 0.61300 | 0.4680 | 4.30e-04 | 7.25e-03 |
| REACTOME COMPLEMENT CASCADE | 11 | 1.12e-04 | 3.01e-03 | 0.729 | -0.50500 | 0.5260 | 3.73e-03 | 2.51e-03 |
| REACTOME NCAM1 INTERACTIONS | 16 | 5.25e-06 | 2.17e-04 | 0.706 | -0.15000 | 0.6900 | 3.00e-01 | 1.74e-06 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 4.18e-04 | 8.65e-03 | 0.682 | 0.12800 | -0.6700 | 4.64e-01 | 1.19e-04 |
| REACTOME MITOCHONDRIAL PROTEIN IMPORT | 42 | 7.29e-13 | 5.53e-11 | 0.662 | 0.12700 | -0.6500 | 1.56e-01 | 3.21e-13 |
| REACTOME EXTRACELLULAR MATRIX ORGANIZATION | 32 | 7.87e-10 | 4.48e-08 | 0.653 | -0.24500 | 0.6050 | 1.66e-02 | 3.11e-09 |
| REACTOME PYRUVATE METABOLISM | 16 | 6.86e-05 | 2.08e-03 | 0.627 | 0.14900 | -0.6090 | 3.02e-01 | 2.48e-05 |
| REACTOME COLLAGEN FORMATION | 27 | 1.86e-07 | 9.39e-06 | 0.612 | -0.21200 | 0.5740 | 5.71e-02 | 2.45e-07 |
| REACTOME GLUCONEOGENESIS | 18 | 3.36e-05 | 1.18e-03 | 0.610 | 0.56100 | -0.2400 | 3.84e-05 | 7.78e-02 |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 11 | 7.54e-03 | 8.37e-02 | 0.550 | -0.16400 | -0.5250 | 3.45e-01 | 2.60e-03 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 10 | 1.61e-02 | 1.59e-01 | 0.532 | -0.24500 | -0.4720 | 1.79e-01 | 9.70e-03 |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 11 | 1.75e-02 | 1.68e-01 | 0.501 | -0.17400 | -0.4700 | 3.18e-01 | 7.00e-03 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | 16 | 3.84e-03 | 5.45e-02 | 0.483 | -0.04120 | -0.4810 | 7.76e-01 | 8.64e-04 |
| REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | 10 | 3.37e-02 | 2.38e-01 | 0.481 | -0.45100 | -0.1670 | 1.36e-02 | 3.59e-01 |
| REACTOME SIGNAL ATTENUATION | 10 | 2.97e-02 | 2.33e-01 | 0.477 | -0.41700 | 0.2320 | 2.25e-02 | 2.04e-01 |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 10 | 3.40e-02 | 2.38e-01 | 0.475 | 0.00166 | -0.4750 | 9.93e-01 | 9.37e-03 |
| REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | 13 | 1.85e-02 | 1.69e-01 | 0.460 | 0.35100 | 0.2970 | 2.84e-02 | 6.34e-02 |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 12 | 3.07e-02 | 2.33e-01 | 0.447 | -0.21000 | -0.3940 | 2.07e-01 | 1.82e-02 |
| REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 17 | 5.77e-03 | 7.02e-02 | 0.445 | -0.42600 | 0.1300 | 2.37e-03 | 3.54e-01 |
| REACTOME PLATELET AGGREGATION PLUG FORMATION | 18 | 6.02e-03 | 7.02e-02 | 0.432 | -0.42000 | 0.0999 | 2.04e-03 | 4.64e-01 |
| REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 20 | 3.45e-03 | 5.07e-02 | 0.428 | -0.25100 | 0.3470 | 5.24e-02 | 7.33e-03 |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 15 | 1.97e-02 | 1.72e-01 | 0.425 | 0.33300 | 0.2640 | 2.55e-02 | 7.67e-02 |
| REACTOME SIGNAL AMPLIFICATION | 14 | 3.18e-02 | 2.33e-01 | 0.410 | -0.15700 | -0.3790 | 3.11e-01 | 1.40e-02 |
| REACTOME SPRY REGULATION OF FGF SIGNALING | 12 | 4.79e-02 | 3.07e-01 | 0.410 | -0.40900 | 0.0272 | 1.42e-02 | 8.71e-01 |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 20 | 5.97e-03 | 7.02e-02 | 0.409 | 0.13300 | -0.3870 | 3.05e-01 | 2.76e-03 |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 20 | 5.97e-03 | 7.02e-02 | 0.409 | 0.13300 | -0.3870 | 3.05e-01 | 2.76e-03 |
| REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 10 | 8.93e-02 | 4.58e-01 | 0.405 | -0.38700 | -0.1220 | 3.43e-02 | 5.03e-01 |
| REACTOME KERATAN SULFATE KERATIN METABOLISM | 14 | 3.13e-02 | 2.33e-01 | 0.405 | -0.03890 | 0.4030 | 8.01e-01 | 9.07e-03 |
| REACTOME METABOLISM OF PORPHYRINS | 11 | 6.13e-02 | 3.72e-01 | 0.404 | 0.27800 | -0.2930 | 1.10e-01 | 9.21e-02 |
| REACTOME HS GAG DEGRADATION | 10 | 9.63e-02 | 4.72e-01 | 0.396 | 0.02670 | 0.3950 | 8.84e-01 | 3.06e-02 |
| REACTOME GPVI MEDIATED ACTIVATION CASCADE | 16 | 2.26e-02 | 1.83e-01 | 0.395 | -0.39000 | 0.0666 | 7.00e-03 | 6.45e-01 |
| REACTOME KERATAN SULFATE BIOSYNTHESIS | 11 | 7.57e-02 | 4.22e-01 | 0.393 | -0.06290 | 0.3880 | 7.18e-01 | 2.58e-02 |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 15 | 3.30e-02 | 2.38e-01 | 0.384 | 0.18300 | -0.3370 | 2.19e-01 | 2.38e-02 |
| REACTOME G PROTEIN ACTIVATION | 10 | 1.14e-01 | 4.98e-01 | 0.380 | 0.00870 | -0.3800 | 9.62e-01 | 3.74e-02 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 13 | 5.51e-02 | 3.48e-01 | 0.379 | -0.25400 | 0.2810 | 1.13e-01 | 7.93e-02 |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 16 | 3.58e-02 | 2.43e-01 | 0.372 | -0.37100 | 0.0272 | 1.03e-02 | 8.50e-01 |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 14 | 6.76e-02 | 4.01e-01 | 0.364 | -0.20300 | -0.3020 | 1.88e-01 | 5.03e-02 |
| REACTOME DOUBLE STRAND BREAK REPAIR | 12 | 1.07e-01 | 4.84e-01 | 0.358 | 0.30100 | 0.1940 | 7.08e-02 | 2.45e-01 |
| REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 40 | 4.07e-04 | 8.65e-03 | 0.355 | -0.28000 | 0.2180 | 2.20e-03 | 1.69e-02 |
| REACTOME METABOLISM OF POLYAMINES | 11 | 1.22e-01 | 5.10e-01 | 0.354 | 0.34300 | -0.0866 | 4.88e-02 | 6.19e-01 |
| REACTOME GLUCOSE METABOLISM | 43 | 3.31e-04 | 7.53e-03 | 0.352 | 0.35000 | -0.0338 | 7.21e-05 | 7.02e-01 |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 11 | 1.26e-01 | 5.17e-01 | 0.351 | 0.34100 | -0.0844 | 5.02e-02 | 6.28e-01 |
| REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 10 | 1.54e-01 | 5.55e-01 | 0.351 | 0.07420 | -0.3430 | 6.85e-01 | 6.08e-02 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.Sed | s.Ex | p.Sed | p.Ex |
|---|---|---|---|---|---|---|---|---|
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 1.23e-10 | 8.01e-09 | 1.11000 | 5.55e-01 | -0.959000 | 8.73e-04 | 8.71e-09 |
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 5.10e-13 | 4.64e-11 | 0.98300 | 3.91e-01 | -0.902000 | 3.15e-03 | 9.83e-12 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 1.01e-31 | 1.54e-29 | 0.89300 | 1.18e-01 | -0.885000 | 1.16e-01 | 4.99e-32 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 1.81e-38 | 4.12e-36 | 0.88300 | 1.89e-01 | -0.863000 | 5.33e-03 | 2.31e-37 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 3.05e-52 | 1.39e-49 | 0.85200 | 2.03e-01 | -0.827000 | 2.97e-04 | 1.04e-49 |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 2.72e-06 | 1.24e-04 | 0.80100 | 2.93e-01 | -0.745000 | 6.77e-02 | 3.27e-06 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 6.77e-17 | 7.70e-15 | 0.80000 | 2.50e-01 | -0.760000 | 7.82e-03 | 5.17e-16 |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 7.58e-05 | 2.15e-03 | 0.77100 | 6.13e-01 | 0.468000 | 4.30e-04 | 7.25e-03 |
| REACTOME COMPLEMENT CASCADE | 11 | 1.12e-04 | 3.01e-03 | 0.72900 | -5.05e-01 | 0.526000 | 3.73e-03 | 2.51e-03 |
| REACTOME NCAM1 INTERACTIONS | 16 | 5.25e-06 | 2.17e-04 | 0.70600 | -1.50e-01 | 0.690000 | 3.00e-01 | 1.74e-06 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 4.18e-04 | 8.65e-03 | 0.68200 | 1.28e-01 | -0.670000 | 4.64e-01 | 1.19e-04 |
| REACTOME MITOCHONDRIAL PROTEIN IMPORT | 42 | 7.29e-13 | 5.53e-11 | 0.66200 | 1.27e-01 | -0.650000 | 1.56e-01 | 3.21e-13 |
| REACTOME EXTRACELLULAR MATRIX ORGANIZATION | 32 | 7.87e-10 | 4.48e-08 | 0.65300 | -2.45e-01 | 0.605000 | 1.66e-02 | 3.11e-09 |
| REACTOME PYRUVATE METABOLISM | 16 | 6.86e-05 | 2.08e-03 | 0.62700 | 1.49e-01 | -0.609000 | 3.02e-01 | 2.48e-05 |
| REACTOME COLLAGEN FORMATION | 27 | 1.86e-07 | 9.39e-06 | 0.61200 | -2.12e-01 | 0.574000 | 5.71e-02 | 2.45e-07 |
| REACTOME GLUCONEOGENESIS | 18 | 3.36e-05 | 1.18e-03 | 0.61000 | 5.61e-01 | -0.240000 | 3.84e-05 | 7.78e-02 |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 11 | 7.54e-03 | 8.37e-02 | 0.55000 | -1.64e-01 | -0.525000 | 3.45e-01 | 2.60e-03 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 10 | 1.61e-02 | 1.59e-01 | 0.53200 | -2.45e-01 | -0.472000 | 1.79e-01 | 9.70e-03 |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 11 | 1.75e-02 | 1.68e-01 | 0.50100 | -1.74e-01 | -0.470000 | 3.18e-01 | 7.00e-03 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | 16 | 3.84e-03 | 5.45e-02 | 0.48300 | -4.12e-02 | -0.481000 | 7.76e-01 | 8.64e-04 |
| REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | 10 | 3.37e-02 | 2.38e-01 | 0.48100 | -4.51e-01 | -0.167000 | 1.36e-02 | 3.59e-01 |
| REACTOME SIGNAL ATTENUATION | 10 | 2.97e-02 | 2.33e-01 | 0.47700 | -4.17e-01 | 0.232000 | 2.25e-02 | 2.04e-01 |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 10 | 3.40e-02 | 2.38e-01 | 0.47500 | 1.66e-03 | -0.475000 | 9.93e-01 | 9.37e-03 |
| REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | 13 | 1.85e-02 | 1.69e-01 | 0.46000 | 3.51e-01 | 0.297000 | 2.84e-02 | 6.34e-02 |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 12 | 3.07e-02 | 2.33e-01 | 0.44700 | -2.10e-01 | -0.394000 | 2.07e-01 | 1.82e-02 |
| REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 17 | 5.77e-03 | 7.02e-02 | 0.44500 | -4.26e-01 | 0.130000 | 2.37e-03 | 3.54e-01 |
| REACTOME PLATELET AGGREGATION PLUG FORMATION | 18 | 6.02e-03 | 7.02e-02 | 0.43200 | -4.20e-01 | 0.099900 | 2.04e-03 | 4.64e-01 |
| REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 20 | 3.45e-03 | 5.07e-02 | 0.42800 | -2.51e-01 | 0.347000 | 5.24e-02 | 7.33e-03 |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 15 | 1.97e-02 | 1.72e-01 | 0.42500 | 3.33e-01 | 0.264000 | 2.55e-02 | 7.67e-02 |
| REACTOME SIGNAL AMPLIFICATION | 14 | 3.18e-02 | 2.33e-01 | 0.41000 | -1.57e-01 | -0.379000 | 3.11e-01 | 1.40e-02 |
| REACTOME SPRY REGULATION OF FGF SIGNALING | 12 | 4.79e-02 | 3.07e-01 | 0.41000 | -4.09e-01 | 0.027200 | 1.42e-02 | 8.71e-01 |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 20 | 5.97e-03 | 7.02e-02 | 0.40900 | 1.33e-01 | -0.387000 | 3.05e-01 | 2.76e-03 |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 20 | 5.97e-03 | 7.02e-02 | 0.40900 | 1.33e-01 | -0.387000 | 3.05e-01 | 2.76e-03 |
| REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 10 | 8.93e-02 | 4.58e-01 | 0.40500 | -3.87e-01 | -0.122000 | 3.43e-02 | 5.03e-01 |
| REACTOME KERATAN SULFATE KERATIN METABOLISM | 14 | 3.13e-02 | 2.33e-01 | 0.40500 | -3.89e-02 | 0.403000 | 8.01e-01 | 9.07e-03 |
| REACTOME METABOLISM OF PORPHYRINS | 11 | 6.13e-02 | 3.72e-01 | 0.40400 | 2.78e-01 | -0.293000 | 1.10e-01 | 9.21e-02 |
| REACTOME HS GAG DEGRADATION | 10 | 9.63e-02 | 4.72e-01 | 0.39600 | 2.67e-02 | 0.395000 | 8.84e-01 | 3.06e-02 |
| REACTOME GPVI MEDIATED ACTIVATION CASCADE | 16 | 2.26e-02 | 1.83e-01 | 0.39500 | -3.90e-01 | 0.066600 | 7.00e-03 | 6.45e-01 |
| REACTOME KERATAN SULFATE BIOSYNTHESIS | 11 | 7.57e-02 | 4.22e-01 | 0.39300 | -6.29e-02 | 0.388000 | 7.18e-01 | 2.58e-02 |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 15 | 3.30e-02 | 2.38e-01 | 0.38400 | 1.83e-01 | -0.337000 | 2.19e-01 | 2.38e-02 |
| REACTOME G PROTEIN ACTIVATION | 10 | 1.14e-01 | 4.98e-01 | 0.38000 | 8.70e-03 | -0.380000 | 9.62e-01 | 3.74e-02 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 13 | 5.51e-02 | 3.48e-01 | 0.37900 | -2.54e-01 | 0.281000 | 1.13e-01 | 7.93e-02 |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 16 | 3.58e-02 | 2.43e-01 | 0.37200 | -3.71e-01 | 0.027200 | 1.03e-02 | 8.50e-01 |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 14 | 6.76e-02 | 4.01e-01 | 0.36400 | -2.03e-01 | -0.302000 | 1.88e-01 | 5.03e-02 |
| REACTOME DOUBLE STRAND BREAK REPAIR | 12 | 1.07e-01 | 4.84e-01 | 0.35800 | 3.01e-01 | 0.194000 | 7.08e-02 | 2.45e-01 |
| REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 40 | 4.07e-04 | 8.65e-03 | 0.35500 | -2.80e-01 | 0.218000 | 2.20e-03 | 1.69e-02 |
| REACTOME METABOLISM OF POLYAMINES | 11 | 1.22e-01 | 5.10e-01 | 0.35400 | 3.43e-01 | -0.086600 | 4.88e-02 | 6.19e-01 |
| REACTOME GLUCOSE METABOLISM | 43 | 3.31e-04 | 7.53e-03 | 0.35200 | 3.50e-01 | -0.033800 | 7.21e-05 | 7.02e-01 |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 11 | 1.26e-01 | 5.17e-01 | 0.35100 | 3.41e-01 | -0.084400 | 5.02e-02 | 6.28e-01 |
| REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 10 | 1.54e-01 | 5.55e-01 | 0.35100 | 7.42e-02 | -0.343000 | 6.85e-01 | 6.08e-02 |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 45 | 2.37e-04 | 5.83e-03 | 0.35000 | -5.10e-02 | 0.347000 | 5.54e-01 | 5.81e-05 |
| REACTOME CTLA4 INHIBITORY SIGNALING | 15 | 7.73e-02 | 4.22e-01 | 0.34100 | -3.25e-01 | -0.101000 | 2.91e-02 | 4.99e-01 |
| REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | 35 | 2.22e-03 | 3.74e-02 | 0.33900 | -8.23e-02 | 0.329000 | 4.00e-01 | 7.75e-04 |
| REACTOME REGULATION OF SIGNALING BY CBL | 13 | 1.17e-01 | 4.98e-01 | 0.33600 | -3.08e-01 | -0.135000 | 5.48e-02 | 4.00e-01 |
| REACTOME LIPOPROTEIN METABOLISM | 11 | 1.48e-01 | 5.55e-01 | 0.33500 | -1.75e-01 | 0.286000 | 3.16e-01 | 1.01e-01 |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 23 | 1.96e-02 | 1.72e-01 | 0.33300 | -1.55e-01 | 0.295000 | 1.98e-01 | 1.45e-02 |
| REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | 20 | 3.51e-02 | 2.42e-01 | 0.33200 | 3.27e-01 | -0.057300 | 1.13e-02 | 6.57e-01 |
| REACTOME GLUTATHIONE CONJUGATION | 12 | 1.35e-01 | 5.43e-01 | 0.33200 | 3.28e-01 | -0.050000 | 4.93e-02 | 7.65e-01 |
| REACTOME SYNTHESIS OF PA | 10 | 1.91e-01 | 6.14e-01 | 0.32700 | 1.60e-01 | -0.285000 | 3.80e-01 | 1.19e-01 |
| REACTOME STRIATED MUSCLE CONTRACTION | 22 | 2.95e-02 | 2.33e-01 | 0.32700 | 1.03e-02 | -0.326000 | 9.34e-01 | 8.09e-03 |
| REACTOME FATTY ACYL COA BIOSYNTHESIS | 10 | 1.95e-01 | 6.14e-01 | 0.32500 | -2.29e-01 | 0.230000 | 2.09e-01 | 2.09e-01 |
| REACTOME SIGNALING BY NODAL | 11 | 1.98e-01 | 6.14e-01 | 0.31500 | 5.84e-02 | 0.310000 | 7.37e-01 | 7.55e-02 |
| REACTOME RNA POL I TRANSCRIPTION TERMINATION | 19 | 5.61e-02 | 3.49e-01 | 0.31400 | 2.94e-01 | -0.111000 | 2.64e-02 | 4.03e-01 |
| REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | 21 | 4.26e-02 | 2.77e-01 | 0.31400 | -3.06e-01 | 0.070000 | 1.51e-02 | 5.79e-01 |
| REACTOME TIE2 SIGNALING | 13 | 1.56e-01 | 5.55e-01 | 0.31400 | -2.63e-01 | -0.171000 | 1.01e-01 | 2.86e-01 |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | 11 | 1.89e-01 | 6.14e-01 | 0.31300 | -2.77e-01 | 0.146000 | 1.11e-01 | 4.02e-01 |
| REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | 28 | 2.14e-02 | 1.77e-01 | 0.30800 | 2.44e-01 | 0.188000 | 2.53e-02 | 8.61e-02 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 83 | 1.03e-05 | 3.92e-04 | 0.30700 | -7.63e-02 | -0.298000 | 2.31e-01 | 2.89e-06 |
| REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | 14 | 1.34e-01 | 5.43e-01 | 0.30400 | 1.98e-01 | -0.231000 | 2.00e-01 | 1.34e-01 |
| REACTOME ION CHANNEL TRANSPORT | 18 | 8.58e-02 | 4.49e-01 | 0.30400 | -2.96e-01 | -0.067800 | 2.96e-02 | 6.19e-01 |
| REACTOME SIGNALING BY NOTCH3 | 10 | 2.77e-01 | 7.34e-01 | 0.29700 | -1.63e-01 | -0.249000 | 3.73e-01 | 1.73e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | 14 | 1.68e-01 | 5.88e-01 | 0.29600 | 2.56e-01 | 0.148000 | 9.68e-02 | 3.38e-01 |
| REACTOME PEPTIDE CHAIN ELONGATION | 67 | 2.43e-04 | 5.83e-03 | 0.29300 | -1.34e-01 | -0.260000 | 5.90e-02 | 2.34e-04 |
| REACTOME MYOGENESIS | 21 | 6.78e-02 | 4.01e-01 | 0.29200 | -2.65e-02 | 0.290000 | 8.33e-01 | 2.13e-02 |
| REACTOME G ALPHA Z SIGNALLING EVENTS | 20 | 7.32e-02 | 4.22e-01 | 0.29000 | 1.98e-01 | -0.213000 | 1.26e-01 | 9.97e-02 |
| REACTOME ION TRANSPORT BY P TYPE ATPASES | 17 | 1.25e-01 | 5.17e-01 | 0.28800 | -2.79e-01 | -0.070800 | 4.64e-02 | 6.14e-01 |
| REACTOME VIRAL MESSENGER RNA SYNTHESIS | 14 | 1.72e-01 | 5.89e-01 | 0.28500 | 1.35e-01 | -0.252000 | 3.83e-01 | 1.03e-01 |
| REACTOME TRAFFICKING OF AMPA RECEPTORS | 15 | 1.64e-01 | 5.80e-01 | 0.28500 | 5.36e-02 | 0.280000 | 7.19e-01 | 6.05e-02 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 18 | 1.15e-01 | 4.98e-01 | 0.28400 | -2.82e-01 | -0.035100 | 3.82e-02 | 7.96e-01 |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 14 | 1.84e-01 | 6.14e-01 | 0.28300 | 2.98e-02 | -0.281000 | 8.47e-01 | 6.84e-02 |
| REACTOME TRNA AMINOACYLATION | 39 | 9.08e-03 | 9.38e-02 | 0.28200 | 2.79e-01 | -0.041700 | 2.56e-03 | 6.52e-01 |
| REACTOME CYTOSOLIC TRNA AMINOACYLATION | 22 | 7.54e-02 | 4.22e-01 | 0.28200 | 2.74e-01 | 0.069900 | 2.64e-02 | 5.70e-01 |
| REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | 10 | 3.04e-01 | 7.68e-01 | 0.28100 | -3.16e-02 | 0.279000 | 8.63e-01 | 1.27e-01 |
| REACTOME HS GAG BIOSYNTHESIS | 14 | 2.12e-01 | 6.39e-01 | 0.27600 | 1.21e-01 | 0.247000 | 4.32e-01 | 1.09e-01 |
| REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | 11 | 2.78e-01 | 7.34e-01 | 0.27500 | -2.42e-01 | 0.130000 | 1.65e-01 | 4.56e-01 |
| REACTOME O LINKED GLYCOSYLATION OF MUCINS | 10 | 3.36e-01 | 7.95e-01 | 0.27400 | 1.68e-01 | 0.217000 | 3.57e-01 | 2.35e-01 |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 43 | 8.12e-03 | 8.80e-02 | 0.27400 | -2.73e-01 | -0.022700 | 1.94e-03 | 7.97e-01 |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | 10 | 3.36e-01 | 7.95e-01 | 0.27400 | -2.39e-01 | -0.134000 | 1.91e-01 | 4.63e-01 |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 13 | 2.34e-01 | 6.86e-01 | 0.27300 | 2.73e-01 | -0.005890 | 8.86e-02 | 9.71e-01 |
| REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | 19 | 1.15e-01 | 4.98e-01 | 0.27300 | 2.57e-01 | -0.092100 | 5.29e-02 | 4.87e-01 |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | 15 | 2.08e-01 | 6.36e-01 | 0.26900 | -2.05e-01 | -0.174000 | 1.69e-01 | 2.44e-01 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 12 | 2.62e-01 | 7.18e-01 | 0.26900 | -2.27e-01 | 0.144000 | 1.74e-01 | 3.88e-01 |
| REACTOME EGFR DOWNREGULATION | 23 | 8.20e-02 | 4.34e-01 | 0.26500 | -1.38e-01 | 0.226000 | 2.51e-01 | 6.04e-02 |
| REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | 11 | 3.18e-01 | 7.88e-01 | 0.26500 | -2.62e-01 | -0.041400 | 1.33e-01 | 8.12e-01 |
| REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | 13 | 2.57e-01 | 7.11e-01 | 0.26400 | 1.04e-02 | -0.263000 | 9.48e-01 | 1.00e-01 |
| REACTOME GLYCOLYSIS | 19 | 1.44e-01 | 5.52e-01 | 0.26300 | 2.50e-01 | 0.084700 | 5.99e-02 | 5.23e-01 |
| REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | 22 | 9.99e-02 | 4.76e-01 | 0.26200 | -7.01e-02 | 0.252000 | 5.70e-01 | 4.05e-02 |
| REACTOME MICRORNA MIRNA BIOGENESIS | 18 | 1.49e-01 | 5.55e-01 | 0.26200 | 2.24e-01 | -0.134000 | 9.97e-02 | 3.24e-01 |
| REACTOME EXTENSION OF TELOMERES | 13 | 2.55e-01 | 7.11e-01 | 0.26100 | 2.35e-01 | -0.113000 | 1.42e-01 | 4.80e-01 |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 13 | 2.79e-01 | 7.34e-01 | 0.26000 | -2.08e-01 | -0.157000 | 1.94e-01 | 3.28e-01 |
| REACTOME PROLONGED ERK ACTIVATION EVENTS | 16 | 1.98e-01 | 6.14e-01 | 0.25900 | -2.58e-01 | 0.023100 | 7.41e-02 | 8.73e-01 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | 11 | 3.51e-01 | 7.95e-01 | 0.25700 | -1.98e-01 | -0.163000 | 2.56e-01 | 3.49e-01 |
| REACTOME PURINE METABOLISM | 25 | 8.95e-02 | 4.58e-01 | 0.25000 | 2.17e-01 | -0.124000 | 6.05e-02 | 2.83e-01 |
| REACTOME ACTIVATION OF BH3 ONLY PROTEINS | 10 | 4.11e-01 | 8.04e-01 | 0.24800 | -1.99e-01 | -0.147000 | 2.76e-01 | 4.20e-01 |
| REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 21 | 1.51e-01 | 5.55e-01 | 0.24600 | 2.19e-02 | 0.245000 | 8.62e-01 | 5.23e-02 |
| REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | 18 | 1.90e-01 | 6.14e-01 | 0.24500 | -8.89e-02 | 0.229000 | 5.14e-01 | 9.33e-02 |
| REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | 22 | 1.37e-01 | 5.43e-01 | 0.24400 | -4.86e-02 | 0.239000 | 6.93e-01 | 5.24e-02 |
| REACTOME PEROXISOMAL LIPID METABOLISM | 16 | 2.50e-01 | 7.08e-01 | 0.24400 | -1.01e-01 | -0.222000 | 4.85e-01 | 1.25e-01 |
| REACTOME PLATELET HOMEOSTASIS | 32 | 5.76e-02 | 3.54e-01 | 0.24300 | 4.21e-02 | -0.239000 | 6.81e-01 | 1.94e-02 |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 19 | 1.97e-01 | 6.14e-01 | 0.23900 | -2.02e-02 | -0.239000 | 8.79e-01 | 7.20e-02 |
| REACTOME ERKS ARE INACTIVATED | 10 | 4.21e-01 | 8.12e-01 | 0.23900 | -2.38e-01 | 0.027400 | 1.93e-01 | 8.81e-01 |
| REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 21 | 1.71e-01 | 5.89e-01 | 0.23900 | -6.39e-02 | -0.230000 | 6.12e-01 | 6.77e-02 |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 86 | 7.22e-04 | 1.31e-02 | 0.23900 | -3.97e-02 | -0.236000 | 5.25e-01 | 1.63e-04 |
| REACTOME ENOS ACTIVATION AND REGULATION | 12 | 3.66e-01 | 7.95e-01 | 0.23900 | -2.28e-01 | -0.071600 | 1.72e-01 | 6.68e-01 |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 89 | 6.79e-04 | 1.29e-02 | 0.23800 | -1.04e-01 | -0.214000 | 9.22e-02 | 4.92e-04 |
| REACTOME MITOTIC G2 G2 M PHASES | 49 | 1.81e-02 | 1.68e-01 | 0.23800 | 2.10e-01 | 0.110000 | 1.09e-02 | 1.83e-01 |
| REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 43 | 3.09e-02 | 2.33e-01 | 0.23600 | 2.07e-01 | 0.114000 | 1.92e-02 | 1.95e-01 |
| REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | 22 | 1.56e-01 | 5.55e-01 | 0.23600 | 2.33e-01 | -0.039600 | 5.90e-02 | 7.48e-01 |
| REACTOME METAL ION SLC TRANSPORTERS | 12 | 3.80e-01 | 7.95e-01 | 0.23600 | -1.40e-01 | -0.190000 | 4.01e-01 | 2.55e-01 |
| REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 16 | 2.79e-01 | 7.34e-01 | 0.23500 | -1.30e-01 | -0.195000 | 3.68e-01 | 1.77e-01 |
| REACTOME RAP1 SIGNALLING | 12 | 3.80e-01 | 7.95e-01 | 0.23400 | -2.22e-01 | -0.074400 | 1.83e-01 | 6.56e-01 |
| REACTOME MHC CLASS II ANTIGEN PRESENTATION | 60 | 9.34e-03 | 9.44e-02 | 0.23000 | 5.77e-02 | 0.223000 | 4.41e-01 | 2.85e-03 |
| REACTOME PROCESSING OF INTRONLESS PRE MRNAS | 13 | 3.59e-01 | 7.95e-01 | 0.23000 | -1.84e-02 | -0.229000 | 9.08e-01 | 1.52e-01 |
| REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | 25 | 1.37e-01 | 5.43e-01 | 0.22900 | -2.25e-01 | 0.040100 | 5.12e-02 | 7.29e-01 |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 85 | 1.56e-03 | 2.73e-02 | 0.22900 | -8.90e-02 | -0.211000 | 1.57e-01 | 7.98e-04 |
| REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 21 | 1.93e-01 | 6.14e-01 | 0.22500 | -1.34e-01 | 0.181000 | 2.88e-01 | 1.52e-01 |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 35 | 7.68e-02 | 4.22e-01 | 0.22500 | -1.08e-01 | -0.197000 | 2.69e-01 | 4.39e-02 |
| REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 13 | 3.90e-01 | 7.95e-01 | 0.22400 | -1.62e-01 | -0.155000 | 3.13e-01 | 3.34e-01 |
| REACTOME SIGNALING BY NOTCH2 | 10 | 4.85e-01 | 8.51e-01 | 0.22400 | -1.52e-01 | -0.164000 | 4.06e-01 | 3.69e-01 |
| REACTOME INWARDLY RECTIFYING K CHANNELS | 10 | 4.78e-01 | 8.46e-01 | 0.22400 | -4.48e-02 | -0.219000 | 8.06e-01 | 2.31e-01 |
| REACTOME GABA B RECEPTOR ACTIVATION | 13 | 3.73e-01 | 7.95e-01 | 0.22300 | 4.16e-02 | -0.220000 | 7.95e-01 | 1.71e-01 |
| REACTOME PRE NOTCH EXPRESSION AND PROCESSING | 31 | 9.15e-02 | 4.63e-01 | 0.22300 | -1.33e-01 | 0.179000 | 2.00e-01 | 8.42e-02 |
| REACTOME DAG AND IP3 SIGNALING | 15 | 3.39e-01 | 7.95e-01 | 0.22300 | 1.71e-01 | 0.143000 | 2.51e-01 | 3.37e-01 |
| REACTOME NEPHRIN INTERACTIONS | 14 | 3.64e-01 | 7.95e-01 | 0.22300 | -1.14e-01 | -0.192000 | 4.61e-01 | 2.15e-01 |
| REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | 13 | 3.94e-01 | 7.95e-01 | 0.22300 | -1.48e-01 | -0.166000 | 3.55e-01 | 3.00e-01 |
| REACTOME EFFECTS OF PIP2 HYDROLYSIS | 13 | 3.96e-01 | 7.95e-01 | 0.22200 | 1.63e-01 | 0.151000 | 3.09e-01 | 3.47e-01 |
| REACTOME APOPTOTIC EXECUTION PHASE | 27 | 1.48e-01 | 5.55e-01 | 0.22100 | 1.22e-01 | 0.184000 | 2.71e-01 | 9.80e-02 |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | 19 | 2.42e-01 | 6.94e-01 | 0.22000 | 1.04e-01 | -0.194000 | 4.35e-01 | 1.43e-01 |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 13 | 3.82e-01 | 7.95e-01 | 0.21900 | -1.00e-01 | 0.195000 | 5.32e-01 | 2.23e-01 |
| REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA | 19 | 2.58e-01 | 7.11e-01 | 0.21900 | -2.69e-02 | -0.217000 | 8.39e-01 | 1.01e-01 |
| REACTOME DEADENYLATION OF MRNA | 16 | 3.09e-01 | 7.69e-01 | 0.21900 | 2.05e-01 | -0.075400 | 1.55e-01 | 6.02e-01 |
| REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | 14 | 3.67e-01 | 7.95e-01 | 0.21900 | 6.25e-05 | -0.219000 | 1.00e+00 | 1.57e-01 |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 10 | 4.78e-01 | 8.46e-01 | 0.21800 | 1.49e-01 | -0.160000 | 4.15e-01 | 3.83e-01 |
| REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 31 | 1.16e-01 | 4.98e-01 | 0.21600 | 2.74e-02 | 0.215000 | 7.92e-01 | 3.87e-02 |
| REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | 16 | 3.49e-01 | 7.95e-01 | 0.21300 | -1.60e-01 | -0.141000 | 2.68e-01 | 3.28e-01 |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 14 | 3.78e-01 | 7.95e-01 | 0.21200 | 9.60e-02 | -0.189000 | 5.34e-01 | 2.20e-01 |
| REACTOME GPCR LIGAND BINDING | 40 | 7.70e-02 | 4.22e-01 | 0.21000 | -1.77e-01 | -0.114000 | 5.34e-02 | 2.12e-01 |
| REACTOME FORMATION OF INCISION COMPLEX IN GG NER | 16 | 3.51e-01 | 7.95e-01 | 0.20900 | 2.09e-01 | 0.006650 | 1.48e-01 | 9.63e-01 |
| REACTOME G ALPHA S SIGNALLING EVENTS | 26 | 1.80e-01 | 6.11e-01 | 0.20700 | 1.05e-01 | -0.178000 | 3.56e-01 | 1.16e-01 |
| REACTOME LYSOSOME VESICLE BIOGENESIS | 17 | 3.40e-01 | 7.95e-01 | 0.20600 | 1.23e-02 | 0.206000 | 9.30e-01 | 1.42e-01 |
| REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | 16 | 3.52e-01 | 7.95e-01 | 0.20600 | 9.31e-02 | -0.184000 | 5.19e-01 | 2.04e-01 |
| REACTOME GABA RECEPTOR ACTIVATION | 14 | 4.14e-01 | 8.05e-01 | 0.20500 | -3.47e-03 | -0.205000 | 9.82e-01 | 1.84e-01 |
| REACTOME CIRCADIAN CLOCK | 42 | 7.89e-02 | 4.22e-01 | 0.20400 | 9.32e-02 | 0.182000 | 2.97e-01 | 4.21e-02 |
| REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | 38 | 1.01e-01 | 4.76e-01 | 0.20400 | 1.74e-01 | 0.107000 | 6.41e-02 | 2.56e-01 |
| REACTOME RNA POL I TRANSCRIPTION INITIATION | 23 | 2.38e-01 | 6.89e-01 | 0.20300 | 2.00e-01 | -0.036000 | 9.74e-02 | 7.65e-01 |
| REACTOME BIOLOGICAL OXIDATIONS | 37 | 9.54e-02 | 4.72e-01 | 0.20300 | 1.07e-01 | -0.172000 | 2.60e-01 | 7.02e-02 |
| REACTOME SMOOTH MUSCLE CONTRACTION | 19 | 3.04e-01 | 7.68e-01 | 0.20200 | 1.88e-01 | -0.074900 | 1.57e-01 | 5.72e-01 |
| REACTOME POTASSIUM CHANNELS | 21 | 2.78e-01 | 7.34e-01 | 0.19900 | 9.12e-02 | -0.177000 | 4.70e-01 | 1.61e-01 |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 31 | 1.72e-01 | 5.89e-01 | 0.19800 | 1.47e-01 | 0.134000 | 1.58e-01 | 1.99e-01 |
| REACTOME G1 PHASE | 25 | 2.26e-01 | 6.68e-01 | 0.19600 | -1.73e-01 | 0.092900 | 1.35e-01 | 4.22e-01 |
| REACTOME CELL JUNCTION ORGANIZATION | 26 | 2.14e-01 | 6.42e-01 | 0.19600 | -1.76e-01 | 0.085800 | 1.20e-01 | 4.49e-01 |
| REACTOME MUSCLE CONTRACTION | 37 | 1.14e-01 | 4.98e-01 | 0.19500 | 1.10e-01 | -0.161000 | 2.48e-01 | 9.05e-02 |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 103 | 2.61e-03 | 4.10e-02 | 0.19400 | 1.19e-01 | -0.153000 | 3.78e-02 | 7.40e-03 |
| REACTOME SIGNALING BY ROBO RECEPTOR | 19 | 3.59e-01 | 7.95e-01 | 0.19100 | 2.72e-02 | 0.189000 | 8.38e-01 | 1.55e-01 |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 57 | 4.22e-02 | 2.77e-01 | 0.19000 | -1.68e-01 | 0.089400 | 2.87e-02 | 2.44e-01 |
| REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | 28 | 2.10e-01 | 6.37e-01 | 0.19000 | 1.06e-01 | -0.157000 | 3.31e-01 | 1.50e-01 |
| REACTOME GLOBAL GENOMIC NER GG NER | 22 | 3.08e-01 | 7.69e-01 | 0.18900 | 1.89e-01 | 0.009140 | 1.25e-01 | 9.41e-01 |
| REACTOME BOTULINUM NEUROTOXICITY | 10 | 5.88e-01 | 8.98e-01 | 0.18800 | -1.88e-01 | -0.001900 | 3.03e-01 | 9.92e-01 |
| REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | 10 | 5.88e-01 | 8.98e-01 | 0.18800 | -1.88e-01 | -0.001900 | 3.03e-01 | 9.92e-01 |
| REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | 38 | 1.42e-01 | 5.52e-01 | 0.18700 | 5.19e-02 | 0.180000 | 5.80e-01 | 5.56e-02 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 42 | 1.07e-01 | 4.84e-01 | 0.18700 | 4.71e-02 | -0.181000 | 5.98e-01 | 4.28e-02 |
| REACTOME TOLL RECEPTOR CASCADES | 72 | 2.11e-02 | 1.77e-01 | 0.18700 | -1.53e-01 | 0.106000 | 2.48e-02 | 1.19e-01 |
| REACTOME PHASE II CONJUGATION | 23 | 2.90e-01 | 7.47e-01 | 0.18700 | 1.54e-01 | -0.105000 | 2.01e-01 | 3.83e-01 |
| REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | 10 | 6.12e-01 | 9.02e-01 | 0.18400 | -1.62e-01 | -0.085800 | 3.74e-01 | 6.38e-01 |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 106 | 5.41e-03 | 7.02e-02 | 0.18200 | -1.82e-01 | -0.007360 | 1.23e-03 | 8.96e-01 |
| REACTOME PRE NOTCH PROCESSING IN GOLGI | 14 | 4.86e-01 | 8.51e-01 | 0.18200 | -1.08e-01 | 0.147000 | 4.85e-01 | 3.41e-01 |
| REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 18 | 4.21e-01 | 8.12e-01 | 0.18200 | 1.39e-01 | 0.118000 | 3.08e-01 | 3.87e-01 |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | 34 | 1.92e-01 | 6.14e-01 | 0.18000 | -1.80e-01 | -0.000180 | 6.95e-02 | 9.99e-01 |
| REACTOME METABOLISM OF CARBOHYDRATES | 124 | 3.23e-03 | 4.90e-02 | 0.17900 | 8.48e-02 | 0.158000 | 1.04e-01 | 2.47e-03 |
| REACTOME MEIOTIC SYNAPSIS | 15 | 4.77e-01 | 8.46e-01 | 0.17900 | -1.65e-01 | 0.068900 | 2.68e-01 | 6.44e-01 |
| REACTOME MRNA CAPPING | 28 | 2.52e-01 | 7.08e-01 | 0.17900 | 8.22e-02 | -0.159000 | 4.52e-01 | 1.46e-01 |
| REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | 17 | 4.37e-01 | 8.21e-01 | 0.17900 | -1.72e-01 | 0.049300 | 2.21e-01 | 7.25e-01 |
| REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 20 | 3.84e-01 | 7.95e-01 | 0.17800 | 1.78e-01 | -0.010700 | 1.69e-01 | 9.34e-01 |
| REACTOME ARMS MEDIATED ACTIVATION | 14 | 5.14e-01 | 8.66e-01 | 0.17800 | -1.78e-01 | -0.001810 | 2.49e-01 | 9.91e-01 |
| REACTOME P38MAPK EVENTS | 10 | 6.13e-01 | 9.02e-01 | 0.17800 | 9.94e-02 | -0.147000 | 5.86e-01 | 4.20e-01 |
| REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | 16 | 4.81e-01 | 8.49e-01 | 0.17700 | 1.53e-01 | 0.090500 | 2.91e-01 | 5.31e-01 |
| REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 15 | 4.91e-01 | 8.55e-01 | 0.17600 | 1.67e-01 | -0.054600 | 2.62e-01 | 7.15e-01 |
| REACTOME SIGNALLING TO P38 VIA RIT AND RIN | 11 | 6.08e-01 | 9.02e-01 | 0.17600 | 6.24e-02 | 0.164000 | 7.20e-01 | 3.45e-01 |
| REACTOME SULFUR AMINO ACID METABOLISM | 17 | 4.52e-01 | 8.36e-01 | 0.17600 | 1.73e-01 | -0.029400 | 2.17e-01 | 8.34e-01 |
| REACTOME REGULATORY RNA PATHWAYS | 21 | 3.77e-01 | 7.95e-01 | 0.17500 | 1.74e-01 | -0.022100 | 1.68e-01 | 8.61e-01 |
| REACTOME GLUCOSE TRANSPORT | 27 | 2.78e-01 | 7.34e-01 | 0.17500 | -1.10e-01 | 0.136000 | 3.23e-01 | 2.21e-01 |
| REACTOME INFLUENZA LIFE CYCLE | 112 | 6.99e-03 | 7.95e-02 | 0.17500 | -6.08e-02 | -0.164000 | 2.68e-01 | 2.82e-03 |
| REACTOME CELL CELL COMMUNICATION | 50 | 1.00e-01 | 4.76e-01 | 0.17500 | -1.73e-01 | 0.021800 | 3.43e-02 | 7.90e-01 |
| REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 49 | 1.05e-01 | 4.84e-01 | 0.17400 | 5.42e-02 | -0.165000 | 5.12e-01 | 4.58e-02 |
| REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | 15 | 5.12e-01 | 8.66e-01 | 0.17100 | -6.14e-02 | 0.159000 | 6.81e-01 | 2.86e-01 |
| REACTOME G ALPHA I SIGNALLING EVENTS | 28 | 3.06e-01 | 7.68e-01 | 0.17000 | -5.37e-02 | -0.161000 | 6.23e-01 | 1.40e-01 |
| REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | 22 | 3.79e-01 | 7.95e-01 | 0.17000 | -5.62e-02 | 0.160000 | 6.48e-01 | 1.94e-01 |
| REACTOME TRANSLATION | 124 | 5.74e-03 | 7.02e-02 | 0.17000 | -6.00e-02 | -0.159000 | 2.51e-01 | 2.38e-03 |
| REACTOME AXON GUIDANCE | 141 | 2.41e-03 | 3.92e-02 | 0.16900 | -3.40e-02 | 0.165000 | 4.88e-01 | 7.36e-04 |
| REACTOME NETRIN1 SIGNALING | 21 | 4.11e-01 | 8.04e-01 | 0.16800 | -1.68e-01 | 0.007310 | 1.83e-01 | 9.54e-01 |
| REACTOME SIGNALING BY NOTCH4 | 10 | 6.65e-01 | 9.09e-01 | 0.16800 | -8.95e-02 | -0.142000 | 6.24e-01 | 4.37e-01 |
| REACTOME DEVELOPMENTAL BIOLOGY | 235 | 5.52e-05 | 1.80e-03 | 0.16700 | -5.64e-02 | 0.157000 | 1.39e-01 | 3.80e-05 |
| REACTOME DOWNSTREAM TCR SIGNALING | 20 | 4.57e-01 | 8.36e-01 | 0.16400 | -9.83e-02 | -0.132000 | 4.47e-01 | 3.08e-01 |
| REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 21 | 4.40e-01 | 8.25e-01 | 0.16400 | 1.29e-01 | 0.102000 | 3.07e-01 | 4.19e-01 |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 24 | 3.97e-01 | 7.95e-01 | 0.16300 | -9.42e-02 | -0.133000 | 4.25e-01 | 2.59e-01 |
| REACTOME PLATELET SENSITIZATION BY LDL | 11 | 6.54e-01 | 9.09e-01 | 0.16300 | -7.57e-02 | -0.144000 | 6.64e-01 | 4.07e-01 |
| REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 20 | 4.65e-01 | 8.36e-01 | 0.16300 | -1.27e-01 | -0.102000 | 3.26e-01 | 4.31e-01 |
| REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | 15 | 5.49e-01 | 8.87e-01 | 0.16200 | -1.58e-01 | 0.037100 | 2.91e-01 | 8.04e-01 |
| REACTOME INNATE IMMUNE SYSTEM | 118 | 8.74e-03 | 9.25e-02 | 0.16200 | -1.29e-01 | 0.098200 | 1.61e-02 | 6.65e-02 |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 15 | 5.55e-01 | 8.89e-01 | 0.16100 | 1.60e-01 | -0.021500 | 2.85e-01 | 8.85e-01 |
| REACTOME ACTIVATED TLR4 SIGNALLING | 59 | 9.80e-02 | 4.74e-01 | 0.16100 | -1.56e-01 | 0.041800 | 3.92e-02 | 5.79e-01 |
| REACTOME CD28 CO STIMULATION | 22 | 4.30e-01 | 8.15e-01 | 0.16100 | -1.58e-01 | -0.028500 | 1.99e-01 | 8.17e-01 |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 52 | 1.44e-01 | 5.52e-01 | 0.16100 | 1.17e-01 | 0.111000 | 1.46e-01 | 1.67e-01 |
| REACTOME SIGNALING BY FGFR MUTANTS | 25 | 3.77e-01 | 7.95e-01 | 0.16100 | -1.60e-01 | 0.015000 | 1.66e-01 | 8.97e-01 |
| REACTOME RNA POL I TRANSCRIPTION | 26 | 3.64e-01 | 7.95e-01 | 0.16100 | 1.60e-01 | -0.016300 | 1.59e-01 | 8.86e-01 |
| REACTOME TCR SIGNALING | 27 | 3.59e-01 | 7.95e-01 | 0.16000 | -1.58e-01 | -0.022500 | 1.55e-01 | 8.40e-01 |
| REACTOME BASIGIN INTERACTIONS | 13 | 6.02e-01 | 9.02e-01 | 0.16000 | -1.52e-01 | 0.049900 | 3.43e-01 | 7.55e-01 |
| REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | 16 | 5.52e-01 | 8.87e-01 | 0.15900 | -5.56e-02 | -0.149000 | 7.00e-01 | 3.02e-01 |
| REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | 42 | 2.03e-01 | 6.25e-01 | 0.15900 | 4.40e-03 | -0.159000 | 9.61e-01 | 7.49e-02 |
| REACTOME SIGNAL TRANSDUCTION BY L1 | 28 | 3.38e-01 | 7.95e-01 | 0.15800 | -8.67e-02 | 0.132000 | 4.27e-01 | 2.26e-01 |
| REACTOME GLYCOSPHINGOLIPID METABOLISM | 19 | 4.98e-01 | 8.61e-01 | 0.15800 | 4.52e-02 | 0.151000 | 7.33e-01 | 2.53e-01 |
| REACTOME SPHINGOLIPID METABOLISM | 34 | 2.89e-01 | 7.47e-01 | 0.15700 | 3.26e-02 | 0.154000 | 7.43e-01 | 1.21e-01 |
| REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | 15 | 5.76e-01 | 8.98e-01 | 0.15700 | 1.65e-02 | 0.156000 | 9.12e-01 | 2.94e-01 |
| REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | 46 | 1.85e-01 | 6.14e-01 | 0.15600 | -8.69e-03 | 0.156000 | 9.19e-01 | 6.72e-02 |
| REACTOME SIGNALING BY PDGF | 85 | 4.22e-02 | 2.77e-01 | 0.15600 | -6.06e-02 | 0.144000 | 3.35e-01 | 2.21e-02 |
| REACTOME SIGNALLING TO ERKS | 28 | 3.62e-01 | 7.95e-01 | 0.15600 | -1.56e-01 | -0.006900 | 1.54e-01 | 9.50e-01 |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 52 | 1.52e-01 | 5.55e-01 | 0.15500 | -1.54e-01 | 0.014500 | 5.44e-02 | 8.56e-01 |
| REACTOME TELOMERE MAINTENANCE | 17 | 5.31e-01 | 8.74e-01 | 0.15500 | 9.93e-02 | -0.119000 | 4.79e-01 | 3.96e-01 |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 55 | 1.40e-01 | 5.50e-01 | 0.15400 | -1.53e-01 | 0.017900 | 5.00e-02 | 8.19e-01 |
| REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 12 | 6.63e-01 | 9.09e-01 | 0.15400 | -1.23e-01 | -0.092100 | 4.61e-01 | 5.81e-01 |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 21 | 4.65e-01 | 8.36e-01 | 0.15300 | 9.27e-02 | -0.122000 | 4.62e-01 | 3.32e-01 |
| REACTOME SIGNALING BY NOTCH | 71 | 7.79e-02 | 4.22e-01 | 0.15300 | -7.32e-02 | 0.134000 | 2.87e-01 | 5.06e-02 |
| REACTOME RNA POL III TRANSCRIPTION TERMINATION | 18 | 5.25e-01 | 8.71e-01 | 0.15200 | 9.38e-02 | -0.120000 | 4.91e-01 | 3.80e-01 |
| REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | 18 | 5.39e-01 | 8.80e-01 | 0.15100 | -1.64e-02 | 0.150000 | 9.04e-01 | 2.71e-01 |
| REACTOME INTERFERON GAMMA SIGNALING | 23 | 4.70e-01 | 8.41e-01 | 0.15000 | 7.18e-02 | 0.132000 | 5.51e-01 | 2.73e-01 |
| REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | 16 | 5.79e-01 | 8.98e-01 | 0.14900 | -1.38e-01 | 0.057100 | 3.41e-01 | 6.93e-01 |
| REACTOME DESTABILIZATION OF MRNA BY BRF1 | 16 | 5.87e-01 | 8.98e-01 | 0.14800 | 2.85e-02 | -0.145000 | 8.44e-01 | 3.15e-01 |
| REACTOME REGULATION OF INSULIN SECRETION | 36 | 3.21e-01 | 7.90e-01 | 0.14800 | -8.84e-02 | -0.118000 | 3.59e-01 | 2.20e-01 |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 27 | 4.34e-01 | 8.19e-01 | 0.14500 | 1.39e-01 | 0.040500 | 2.10e-01 | 7.16e-01 |
| REACTOME CA DEPENDENT EVENTS | 13 | 6.69e-01 | 9.09e-01 | 0.14500 | 1.38e-01 | 0.045900 | 3.90e-01 | 7.75e-01 |
| REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | 20 | 5.32e-01 | 8.74e-01 | 0.14500 | -1.15e-02 | 0.144000 | 9.29e-01 | 2.64e-01 |
| REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | 14 | 6.55e-01 | 9.09e-01 | 0.14400 | 1.24e-01 | 0.072700 | 4.20e-01 | 6.38e-01 |
| REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 17 | 5.85e-01 | 8.98e-01 | 0.14400 | 1.41e-01 | -0.028100 | 3.13e-01 | 8.41e-01 |
| REACTOME METABOLISM OF MRNA | 176 | 5.24e-03 | 7.02e-02 | 0.14300 | -2.46e-02 | -0.141000 | 5.76e-01 | 1.33e-03 |
| REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | 21 | 5.24e-01 | 8.71e-01 | 0.14300 | -1.42e-01 | 0.017700 | 2.62e-01 | 8.88e-01 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 135 | 1.80e-02 | 1.68e-01 | 0.14200 | 5.67e-03 | 0.142000 | 9.10e-01 | 4.58e-03 |
| REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 46 | 2.48e-01 | 7.05e-01 | 0.14200 | -1.41e-01 | 0.016300 | 9.86e-02 | 8.49e-01 |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 22 | 5.08e-01 | 8.66e-01 | 0.14100 | 1.17e-01 | -0.078300 | 3.41e-01 | 5.25e-01 |
| REACTOME CTNNB1 PHOSPHORYLATION CASCADE | 14 | 6.54e-01 | 9.09e-01 | 0.14100 | -1.33e-01 | 0.044800 | 3.88e-01 | 7.72e-01 |
| REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | 17 | 6.15e-01 | 9.02e-01 | 0.14100 | -1.15e-01 | -0.080500 | 4.11e-01 | 5.66e-01 |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 56 | 1.97e-01 | 6.14e-01 | 0.13800 | -1.36e-01 | 0.028500 | 7.99e-02 | 7.13e-01 |
| REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 19 | 5.95e-01 | 8.98e-01 | 0.13700 | 1.25e-01 | 0.056600 | 3.47e-01 | 6.70e-01 |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 39 | 3.48e-01 | 7.95e-01 | 0.13600 | -6.24e-02 | -0.121000 | 5.00e-01 | 1.90e-01 |
| REACTOME SEMA4D IN SEMAPHORIN SIGNALING | 21 | 5.61e-01 | 8.95e-01 | 0.13500 | -3.73e-03 | 0.135000 | 9.76e-01 | 2.83e-01 |
| REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | 16 | 6.41e-01 | 9.09e-01 | 0.13500 | 2.62e-02 | -0.133000 | 8.56e-01 | 3.58e-01 |
| REACTOME RNA POL III CHAIN ELONGATION | 16 | 6.39e-01 | 9.09e-01 | 0.13500 | 1.14e-01 | -0.071800 | 4.31e-01 | 6.19e-01 |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | 16 | 6.52e-01 | 9.09e-01 | 0.13300 | -1.63e-02 | 0.132000 | 9.10e-01 | 3.61e-01 |
| REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | 17 | 6.32e-01 | 9.09e-01 | 0.13300 | 4.76e-02 | -0.124000 | 7.34e-01 | 3.77e-01 |
| REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | 17 | 6.32e-01 | 9.09e-01 | 0.13300 | 4.76e-02 | -0.124000 | 7.34e-01 | 3.77e-01 |
| REACTOME MRNA SPLICING MINOR PATHWAY | 38 | 3.56e-01 | 7.95e-01 | 0.13300 | 1.05e-01 | -0.081200 | 2.64e-01 | 3.87e-01 |
| REACTOME SIGNALING BY NOTCH1 | 47 | 2.87e-01 | 7.47e-01 | 0.13300 | -2.24e-02 | 0.131000 | 7.91e-01 | 1.22e-01 |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 50 | 2.72e-01 | 7.34e-01 | 0.13200 | -1.32e-01 | -0.008610 | 1.07e-01 | 9.16e-01 |
| REACTOME METABOLISM OF PROTEINS | 301 | 4.95e-04 | 9.79e-03 | 0.13200 | -9.73e-03 | -0.132000 | 7.74e-01 | 9.67e-05 |
| REACTOME NUCLEOTIDE EXCISION REPAIR | 37 | 3.74e-01 | 7.95e-01 | 0.13200 | 1.27e-01 | -0.036100 | 1.82e-01 | 7.04e-01 |
| REACTOME ASPARAGINE N LINKED GLYCOSYLATION | 63 | 1.94e-01 | 6.14e-01 | 0.13200 | -7.34e-03 | 0.132000 | 9.20e-01 | 7.11e-02 |
| REACTOME INTERFERON SIGNALING | 74 | 1.52e-01 | 5.55e-01 | 0.13200 | 2.44e-02 | 0.129000 | 7.18e-01 | 5.49e-02 |
| REACTOME IL RECEPTOR SHC SIGNALING | 15 | 6.71e-01 | 9.09e-01 | 0.13100 | 1.18e-01 | -0.057400 | 4.28e-01 | 7.00e-01 |
| REACTOME SIGNALING BY HIPPO | 15 | 6.83e-01 | 9.14e-01 | 0.13100 | 3.24e-02 | 0.127000 | 8.28e-01 | 3.94e-01 |
| REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | 36 | 3.90e-01 | 7.95e-01 | 0.13100 | 4.35e-02 | -0.123000 | 6.52e-01 | 2.01e-01 |
| REACTOME G2 M CHECKPOINTS | 17 | 6.53e-01 | 9.09e-01 | 0.13000 | 1.73e-02 | 0.129000 | 9.02e-01 | 3.58e-01 |
| REACTOME MEIOSIS | 24 | 5.36e-01 | 8.77e-01 | 0.13000 | -7.56e-02 | 0.105000 | 5.22e-01 | 3.72e-01 |
| REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 14 | 6.97e-01 | 9.20e-01 | 0.12900 | 1.01e-01 | -0.079800 | 5.12e-01 | 6.06e-01 |
| REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 17 | 6.64e-01 | 9.09e-01 | 0.12900 | -1.08e-01 | -0.070300 | 4.41e-01 | 6.16e-01 |
| REACTOME DIABETES PATHWAYS | 90 | 1.06e-01 | 4.84e-01 | 0.12800 | -3.25e-02 | 0.124000 | 5.95e-01 | 4.21e-02 |
| REACTOME SIGNALING BY FGFR1 MUTANTS | 19 | 6.19e-01 | 9.02e-01 | 0.12800 | -1.20e-01 | 0.046700 | 3.67e-01 | 7.25e-01 |
| REACTOME DEADENYLATION DEPENDENT MRNA DECAY | 37 | 3.91e-01 | 7.95e-01 | 0.12800 | 1.05e-01 | -0.072900 | 2.68e-01 | 4.43e-01 |
| REACTOME PLC BETA MEDIATED EVENTS | 19 | 6.36e-01 | 9.09e-01 | 0.12800 | 1.11e-01 | 0.063700 | 4.03e-01 | 6.31e-01 |
| REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | 31 | 4.63e-01 | 8.36e-01 | 0.12800 | -3.15e-02 | 0.124000 | 7.61e-01 | 2.33e-01 |
| REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | 18 | 6.51e-01 | 9.09e-01 | 0.12800 | 1.21e-01 | 0.040200 | 3.74e-01 | 7.68e-01 |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 17 | 6.62e-01 | 9.09e-01 | 0.12700 | 1.26e-01 | -0.009130 | 3.67e-01 | 9.48e-01 |
| REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | 13 | 7.42e-01 | 9.38e-01 | 0.12600 | 7.58e-02 | 0.101000 | 6.36e-01 | 5.30e-01 |
| REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 18 | 6.43e-01 | 9.09e-01 | 0.12600 | -1.04e-01 | 0.070200 | 4.43e-01 | 6.06e-01 |
| REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | 13 | 7.41e-01 | 9.38e-01 | 0.12400 | 8.04e-03 | 0.124000 | 9.60e-01 | 4.38e-01 |
| REACTOME MTORC1 MEDIATED SIGNALLING | 11 | 7.70e-01 | 9.44e-01 | 0.12400 | 8.18e-02 | -0.092800 | 6.39e-01 | 5.94e-01 |
| REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | 10 | 7.91e-01 | 9.44e-01 | 0.12300 | 1.09e-01 | -0.058600 | 5.52e-01 | 7.48e-01 |
| REACTOME DNA REPAIR | 65 | 2.36e-01 | 6.88e-01 | 0.12300 | 1.17e-01 | 0.039200 | 1.04e-01 | 5.85e-01 |
| REACTOME SIGNALING BY SCF KIT | 56 | 2.91e-01 | 7.47e-01 | 0.12300 | -1.14e-01 | -0.046000 | 1.40e-01 | 5.53e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | 23 | 6.08e-01 | 9.02e-01 | 0.12200 | -3.92e-02 | -0.115000 | 7.45e-01 | 3.40e-01 |
| REACTOME PHOSPHORYLATION OF THE APC C | 14 | 7.33e-01 | 9.38e-01 | 0.12100 | 1.20e-01 | -0.018500 | 4.38e-01 | 9.04e-01 |
| REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | 18 | 6.79e-01 | 9.11e-01 | 0.12100 | -1.19e-01 | -0.019900 | 3.83e-01 | 8.84e-01 |
| REACTOME ERK MAPK TARGETS | 18 | 6.69e-01 | 9.09e-01 | 0.12000 | -1.08e-01 | 0.053300 | 4.28e-01 | 6.96e-01 |
| REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX | 35 | 4.60e-01 | 8.36e-01 | 0.12000 | 8.28e-02 | -0.086500 | 3.97e-01 | 3.76e-01 |
| REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 49 | 3.50e-01 | 7.95e-01 | 0.11900 | -1.41e-02 | 0.118000 | 8.65e-01 | 1.52e-01 |
| REACTOME SEMAPHORIN INTERACTIONS | 41 | 4.08e-01 | 8.04e-01 | 0.11900 | -7.15e-02 | 0.095100 | 4.29e-01 | 2.93e-01 |
| REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | 26 | 5.72e-01 | 8.98e-01 | 0.11900 | -3.12e-02 | 0.115000 | 7.83e-01 | 3.13e-01 |
| REACTOME METABOLISM OF NON CODING RNA | 39 | 4.30e-01 | 8.15e-01 | 0.11800 | -1.02e-01 | 0.060500 | 2.71e-01 | 5.14e-01 |
| REACTOME GROWTH HORMONE RECEPTOR SIGNALING | 15 | 7.35e-01 | 9.38e-01 | 0.11800 | -1.08e-01 | -0.048400 | 4.69e-01 | 7.45e-01 |
| REACTOME MAP KINASE ACTIVATION IN TLR CASCADE | 41 | 4.23e-01 | 8.12e-01 | 0.11800 | -1.18e-01 | 0.006500 | 1.91e-01 | 9.43e-01 |
| REACTOME SIGNALING BY BMP | 17 | 7.14e-01 | 9.29e-01 | 0.11700 | 8.75e-02 | 0.077800 | 5.32e-01 | 5.79e-01 |
| REACTOME ELONGATION ARREST AND RECOVERY | 24 | 6.04e-01 | 9.02e-01 | 0.11700 | 8.56e-02 | -0.079000 | 4.68e-01 | 5.03e-01 |
| REACTOME SHC1 EVENTS IN EGFR SIGNALING | 14 | 7.60e-01 | 9.42e-01 | 0.11600 | 7.89e-02 | 0.085600 | 6.10e-01 | 5.79e-01 |
| REACTOME IL 2 SIGNALING | 25 | 5.96e-01 | 8.98e-01 | 0.11600 | 8.32e-02 | -0.080100 | 4.72e-01 | 4.88e-01 |
| REACTOME METABOLISM OF NUCLEOTIDES | 46 | 3.92e-01 | 7.95e-01 | 0.11500 | 5.17e-02 | -0.103000 | 5.44e-01 | 2.28e-01 |
| REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | 14 | 7.54e-01 | 9.42e-01 | 0.11400 | -7.08e-02 | 0.089300 | 6.47e-01 | 5.63e-01 |
| REACTOME METABOLISM OF RNA | 212 | 2.00e-02 | 1.72e-01 | 0.11300 | -3.79e-02 | -0.107000 | 3.45e-01 | 7.70e-03 |
| REACTOME IRON UPTAKE AND TRANSPORT | 23 | 6.61e-01 | 9.09e-01 | 0.11100 | -9.76e-02 | -0.053500 | 4.18e-01 | 6.57e-01 |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 36 | 5.28e-01 | 8.73e-01 | 0.11100 | -9.91e-02 | -0.049000 | 3.04e-01 | 6.11e-01 |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 45 | 4.42e-01 | 8.25e-01 | 0.11000 | 1.12e-02 | -0.109000 | 8.97e-01 | 2.06e-01 |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | 27 | 6.09e-01 | 9.02e-01 | 0.10900 | -7.08e-02 | 0.082700 | 5.25e-01 | 4.58e-01 |
| REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | 18 | 7.35e-01 | 9.38e-01 | 0.10800 | 4.43e-02 | 0.098800 | 7.45e-01 | 4.68e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | 24 | 6.65e-01 | 9.09e-01 | 0.10800 | -4.85e-02 | -0.096600 | 6.81e-01 | 4.13e-01 |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 57 | 3.86e-01 | 7.95e-01 | 0.10700 | -5.84e-02 | -0.090200 | 4.47e-01 | 2.39e-01 |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 56 | 3.99e-01 | 7.96e-01 | 0.10600 | -1.04e-01 | -0.019500 | 1.80e-01 | 8.01e-01 |
| REACTOME INSULIN RECEPTOR RECYCLING | 15 | 7.89e-01 | 9.44e-01 | 0.10400 | -9.97e-02 | -0.028300 | 5.04e-01 | 8.50e-01 |
| REACTOME DARPP 32 EVENTS | 17 | 7.69e-01 | 9.44e-01 | 0.10300 | 3.30e-02 | 0.097100 | 8.14e-01 | 4.89e-01 |
| REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 50 | 4.57e-01 | 8.36e-01 | 0.10100 | -4.62e-02 | 0.089800 | 5.73e-01 | 2.73e-01 |
| REACTOME SOS MEDIATED SIGNALLING | 13 | 8.19e-01 | 9.44e-01 | 0.09970 | -8.29e-02 | 0.055400 | 6.05e-01 | 7.30e-01 |
| REACTOME TRANSCRIPTION COUPLED NER TC NER | 34 | 5.96e-01 | 8.98e-01 | 0.09970 | 9.26e-02 | -0.037000 | 3.51e-01 | 7.09e-01 |
| REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | 18 | 7.73e-01 | 9.44e-01 | 0.09900 | -3.71e-02 | -0.091800 | 7.85e-01 | 5.01e-01 |
| REACTOME UNFOLDED PROTEIN RESPONSE | 64 | 4.05e-01 | 8.04e-01 | 0.09810 | 2.20e-02 | 0.095600 | 7.61e-01 | 1.87e-01 |
| REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION | 98 | 2.40e-01 | 6.92e-01 | 0.09800 | -3.04e-02 | 0.093100 | 6.04e-01 | 1.12e-01 |
| REACTOME SIGNALING BY RHO GTPASES | 61 | 4.12e-01 | 8.04e-01 | 0.09790 | -9.44e-02 | 0.025700 | 2.03e-01 | 7.29e-01 |
| REACTOME TRIGLYCERIDE BIOSYNTHESIS | 20 | 7.53e-01 | 9.42e-01 | 0.09700 | -9.61e-02 | 0.012800 | 4.57e-01 | 9.21e-01 |
| REACTOME NRAGE SIGNALS DEATH THROUGH JNK | 26 | 6.92e-01 | 9.18e-01 | 0.09680 | -1.47e-02 | 0.095600 | 8.97e-01 | 3.99e-01 |
| REACTOME RNA POL III TRANSCRIPTION | 30 | 6.66e-01 | 9.09e-01 | 0.09620 | -9.18e-02 | -0.028700 | 3.85e-01 | 7.86e-01 |
| REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | 11 | 8.65e-01 | 9.65e-01 | 0.09490 | 8.74e-02 | 0.037000 | 6.16e-01 | 8.32e-01 |
| REACTOME L1CAM INTERACTIONS | 51 | 5.19e-01 | 8.69e-01 | 0.09270 | -1.62e-03 | 0.092700 | 9.84e-01 | 2.53e-01 |
| REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | 11 | 8.72e-01 | 9.65e-01 | 0.09270 | -4.37e-02 | -0.081700 | 8.02e-01 | 6.39e-01 |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 42 | 5.76e-01 | 8.98e-01 | 0.09220 | 5.62e-02 | -0.073000 | 5.29e-01 | 4.14e-01 |
| REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 23 | 7.48e-01 | 9.40e-01 | 0.09120 | 8.94e-02 | -0.017700 | 4.58e-01 | 8.83e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | 11 | 8.71e-01 | 9.65e-01 | 0.09010 | -5.10e-02 | 0.074300 | 7.70e-01 | 6.70e-01 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 16 | 8.24e-01 | 9.44e-01 | 0.08970 | 8.95e-02 | -0.005770 | 5.36e-01 | 9.68e-01 |
| REACTOME ACTIVATION OF GENES BY ATF4 | 18 | 8.05e-01 | 9.44e-01 | 0.08920 | 1.36e-02 | -0.088100 | 9.20e-01 | 5.18e-01 |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 83 | 3.88e-01 | 7.95e-01 | 0.08860 | 3.19e-02 | 0.082700 | 6.16e-01 | 1.94e-01 |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 72 | 4.28e-01 | 8.15e-01 | 0.08800 | 2.74e-02 | -0.083600 | 6.88e-01 | 2.21e-01 |
| REACTOME HIV LIFE CYCLE | 91 | 3.63e-01 | 7.95e-01 | 0.08790 | 4.66e-02 | 0.074600 | 4.44e-01 | 2.20e-01 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 56 | 5.13e-01 | 8.66e-01 | 0.08790 | 7.25e-02 | -0.049700 | 3.49e-01 | 5.21e-01 |
| REACTOME HEMOSTASIS | 210 | 9.65e-02 | 4.72e-01 | 0.08710 | -8.71e-02 | 0.000897 | 3.07e-02 | 9.82e-01 |
| REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | 26 | 7.40e-01 | 9.38e-01 | 0.08660 | 5.05e-02 | -0.070300 | 6.56e-01 | 5.35e-01 |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 60 | 5.00e-01 | 8.62e-01 | 0.08650 | 5.84e-02 | -0.063800 | 4.35e-01 | 3.94e-01 |
| REACTOME SHC MEDIATED SIGNALLING | 13 | 8.64e-01 | 9.65e-01 | 0.08540 | -3.94e-02 | 0.075800 | 8.06e-01 | 6.36e-01 |
| REACTOME NOD1 2 SIGNALING PATHWAY | 17 | 8.26e-01 | 9.44e-01 | 0.08520 | 5.84e-02 | -0.062100 | 6.77e-01 | 6.58e-01 |
| REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | 19 | 8.23e-01 | 9.44e-01 | 0.08320 | -8.16e-02 | -0.016200 | 5.38e-01 | 9.03e-01 |
| REACTOME PYRIMIDINE METABOLISM | 10 | 9.05e-01 | 9.69e-01 | 0.08250 | -7.93e-02 | -0.022800 | 6.64e-01 | 9.01e-01 |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 100 | 3.62e-01 | 7.95e-01 | 0.08170 | -3.21e-02 | 0.075100 | 5.80e-01 | 1.96e-01 |
| REACTOME SIGNALLING BY NGF | 149 | 2.26e-01 | 6.68e-01 | 0.08140 | -2.36e-02 | 0.078000 | 6.21e-01 | 1.02e-01 |
| REACTOME SHC RELATED EVENTS | 14 | 8.69e-01 | 9.65e-01 | 0.08110 | -1.55e-02 | 0.079600 | 9.20e-01 | 6.06e-01 |
| REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 58 | 5.63e-01 | 8.95e-01 | 0.08040 | -3.75e-02 | 0.071100 | 6.22e-01 | 3.50e-01 |
| REACTOME IL1 SIGNALING | 24 | 8.02e-01 | 9.44e-01 | 0.07990 | 5.52e-02 | 0.057700 | 6.40e-01 | 6.25e-01 |
| REACTOME INTERFERON ALPHA BETA SIGNALING | 13 | 8.89e-01 | 9.69e-01 | 0.07920 | 4.96e-02 | 0.061700 | 7.57e-01 | 7.00e-01 |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 53 | 6.23e-01 | 9.06e-01 | 0.07860 | -4.26e-02 | -0.066000 | 5.92e-01 | 4.07e-01 |
| REACTOME CALNEXIN CALRETICULIN CYCLE | 11 | 9.04e-01 | 9.69e-01 | 0.07850 | 1.03e-02 | 0.077800 | 9.53e-01 | 6.55e-01 |
| REACTOME CHROMOSOME MAINTENANCE | 33 | 7.34e-01 | 9.38e-01 | 0.07840 | 7.49e-02 | -0.023300 | 4.57e-01 | 8.17e-01 |
| REACTOME INSULIN SYNTHESIS AND PROCESSING | 13 | 8.87e-01 | 9.69e-01 | 0.07830 | -7.83e-02 | -0.000883 | 6.25e-01 | 9.96e-01 |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 56 | 5.91e-01 | 8.98e-01 | 0.07800 | 4.85e-02 | -0.061100 | 5.31e-01 | 4.30e-01 |
| REACTOME SIGNALING BY ERBB4 | 66 | 5.46e-01 | 8.84e-01 | 0.07720 | 6.30e-02 | -0.044600 | 3.77e-01 | 5.32e-01 |
| REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | 23 | 8.17e-01 | 9.44e-01 | 0.07650 | -1.60e-03 | 0.076500 | 9.89e-01 | 5.26e-01 |
| REACTOME G0 AND EARLY G1 | 11 | 9.12e-01 | 9.69e-01 | 0.07620 | 5.66e-02 | 0.051100 | 7.45e-01 | 7.69e-01 |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 48 | 6.63e-01 | 9.09e-01 | 0.07470 | 3.27e-02 | -0.067200 | 6.96e-01 | 4.21e-01 |
| REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | 17 | 8.65e-01 | 9.65e-01 | 0.07460 | -3.24e-02 | 0.067100 | 8.17e-01 | 6.32e-01 |
| REACTOME SIGNALING BY INSULIN RECEPTOR | 72 | 5.42e-01 | 8.81e-01 | 0.07430 | -5.53e-02 | 0.049600 | 4.19e-01 | 4.68e-01 |
| REACTOME SIGNALING BY EGFR IN CANCER | 82 | 5.12e-01 | 8.66e-01 | 0.07380 | -5.47e-03 | 0.073600 | 9.32e-01 | 2.50e-01 |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 42 | 7.06e-01 | 9.22e-01 | 0.07330 | 5.31e-02 | -0.050500 | 5.52e-01 | 5.72e-01 |
| REACTOME SIGNALING BY ERBB2 | 67 | 5.95e-01 | 8.98e-01 | 0.07320 | 6.48e-02 | 0.034100 | 3.60e-01 | 6.30e-01 |
| REACTOME PI3K CASCADE | 44 | 6.99e-01 | 9.20e-01 | 0.07310 | -1.92e-02 | 0.070600 | 8.26e-01 | 4.19e-01 |
| REACTOME NEURONAL SYSTEM | 86 | 4.97e-01 | 8.61e-01 | 0.07280 | 3.80e-02 | -0.062200 | 5.44e-01 | 3.20e-01 |
| REACTOME PIP3 ACTIVATES AKT SIGNALING | 25 | 8.15e-01 | 9.44e-01 | 0.07260 | 4.37e-02 | -0.058000 | 7.05e-01 | 6.16e-01 |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 23 | 8.39e-01 | 9.50e-01 | 0.07240 | -3.36e-02 | -0.064100 | 7.80e-01 | 5.95e-01 |
| REACTOME PERK REGULATED GENE EXPRESSION | 21 | 8.56e-01 | 9.65e-01 | 0.07150 | -3.92e-02 | -0.059900 | 7.56e-01 | 6.35e-01 |
| REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 24 | 8.30e-01 | 9.44e-01 | 0.07120 | 2.29e-02 | -0.067400 | 8.46e-01 | 5.68e-01 |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 162 | 2.94e-01 | 7.51e-01 | 0.07080 | 6.61e-02 | -0.025400 | 1.49e-01 | 5.80e-01 |
| REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | 36 | 7.70e-01 | 9.44e-01 | 0.07050 | 2.61e-02 | 0.065500 | 7.87e-01 | 4.97e-01 |
| REACTOME OPIOID SIGNALLING | 38 | 7.56e-01 | 9.42e-01 | 0.06990 | 7.70e-03 | -0.069400 | 9.35e-01 | 4.60e-01 |
| REACTOME PI 3K CASCADE | 33 | 7.93e-01 | 9.44e-01 | 0.06980 | -4.72e-02 | -0.051400 | 6.39e-01 | 6.10e-01 |
| REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | 50 | 6.97e-01 | 9.20e-01 | 0.06980 | 8.13e-03 | 0.069300 | 9.21e-01 | 3.97e-01 |
| REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | 12 | 9.14e-01 | 9.69e-01 | 0.06950 | -4.85e-02 | 0.049800 | 7.71e-01 | 7.65e-01 |
| REACTOME PI METABOLISM | 38 | 7.59e-01 | 9.42e-01 | 0.06920 | 6.74e-02 | -0.015500 | 4.73e-01 | 8.69e-01 |
| REACTOME PKB MEDIATED EVENTS | 27 | 8.32e-01 | 9.44e-01 | 0.06860 | 4.15e-02 | 0.054600 | 7.09e-01 | 6.24e-01 |
| REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | 10 | 9.33e-01 | 9.72e-01 | 0.06840 | -1.43e-02 | -0.066900 | 9.38e-01 | 7.14e-01 |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 43 | 7.37e-01 | 9.38e-01 | 0.06770 | 4.39e-02 | -0.051600 | 6.19e-01 | 5.59e-01 |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 42 | 7.45e-01 | 9.39e-01 | 0.06730 | 4.25e-02 | -0.052100 | 6.34e-01 | 5.59e-01 |
| REACTOME DNA STRAND ELONGATION | 12 | 9.24e-01 | 9.69e-01 | 0.06690 | -1.37e-02 | -0.065500 | 9.35e-01 | 6.95e-01 |
| REACTOME PI3K EVENTS IN ERBB4 SIGNALING | 28 | 8.29e-01 | 9.44e-01 | 0.06580 | 4.98e-02 | -0.043000 | 6.49e-01 | 6.94e-01 |
| REACTOME CELL CYCLE CHECKPOINTS | 77 | 6.18e-01 | 9.02e-01 | 0.06540 | 6.25e-02 | 0.019200 | 3.44e-01 | 7.72e-01 |
| REACTOME RECYCLING PATHWAY OF L1 | 19 | 8.88e-01 | 9.69e-01 | 0.06400 | -1.94e-02 | 0.061000 | 8.84e-01 | 6.46e-01 |
| REACTOME FRS2 MEDIATED CASCADE | 15 | 9.14e-01 | 9.69e-01 | 0.06340 | -6.29e-02 | -0.007960 | 6.73e-01 | 9.57e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | 21 | 8.85e-01 | 9.69e-01 | 0.06300 | 2.23e-02 | 0.058900 | 8.60e-01 | 6.41e-01 |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 53 | 7.25e-01 | 9.37e-01 | 0.06270 | 4.03e-02 | -0.048100 | 6.12e-01 | 5.46e-01 |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 138 | 4.60e-01 | 8.36e-01 | 0.06110 | -1.67e-02 | 0.058800 | 7.36e-01 | 2.35e-01 |
| REACTOME PROTEIN FOLDING | 40 | 8.00e-01 | 9.44e-01 | 0.06100 | 6.08e-02 | -0.004440 | 5.06e-01 | 9.61e-01 |
| REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | 12 | 9.36e-01 | 9.72e-01 | 0.06060 | -6.06e-02 | 0.000801 | 7.16e-01 | 9.96e-01 |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 40 | 7.98e-01 | 9.44e-01 | 0.06050 | 3.16e-02 | -0.051600 | 7.30e-01 | 5.73e-01 |
| REACTOME CELL CYCLE | 208 | 3.48e-01 | 7.95e-01 | 0.05960 | 5.33e-02 | 0.026600 | 1.88e-01 | 5.11e-01 |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 62 | 7.14e-01 | 9.29e-01 | 0.05960 | 2.23e-02 | -0.055300 | 7.62e-01 | 4.52e-01 |
| REACTOME GPCR DOWNSTREAM SIGNALING | 102 | 5.84e-01 | 8.98e-01 | 0.05950 | -5.95e-02 | 0.001080 | 3.00e-01 | 9.85e-01 |
| REACTOME G1 S TRANSITION | 67 | 7.19e-01 | 9.31e-01 | 0.05860 | -3.96e-02 | -0.043100 | 5.76e-01 | 5.42e-01 |
| REACTOME MRNA SPLICING | 99 | 5.94e-01 | 8.98e-01 | 0.05850 | 3.99e-02 | -0.042800 | 4.94e-01 | 4.63e-01 |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 46 | 7.91e-01 | 9.44e-01 | 0.05820 | 5.78e-02 | -0.007020 | 4.98e-01 | 9.34e-01 |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 81 | 6.77e-01 | 9.11e-01 | 0.05710 | -6.43e-03 | -0.056700 | 9.20e-01 | 3.79e-01 |
| REACTOME SIGNALLING TO RAS | 20 | 9.07e-01 | 9.69e-01 | 0.05610 | 4.34e-02 | -0.035600 | 7.37e-01 | 7.83e-01 |
| REACTOME SIGNALING BY GPCR | 143 | 5.19e-01 | 8.69e-01 | 0.05530 | -5.43e-02 | 0.010400 | 2.64e-01 | 8.32e-01 |
| REACTOME REGULATION OF APOPTOSIS | 48 | 8.03e-01 | 9.44e-01 | 0.05500 | 5.47e-02 | -0.006180 | 5.13e-01 | 9.41e-01 |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 80 | 6.90e-01 | 9.18e-01 | 0.05490 | -4.39e-02 | 0.033000 | 4.98e-01 | 6.10e-01 |
| REACTOME CELL CYCLE MITOTIC | 183 | 4.54e-01 | 8.36e-01 | 0.05480 | 5.14e-02 | 0.018900 | 2.33e-01 | 6.61e-01 |
| REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | 44 | 8.20e-01 | 9.44e-01 | 0.05460 | -8.60e-03 | 0.053900 | 9.21e-01 | 5.37e-01 |
| REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 58 | 7.78e-01 | 9.44e-01 | 0.05460 | 5.11e-02 | 0.019200 | 5.02e-01 | 8.01e-01 |
| REACTOME IMMUNE SYSTEM | 504 | 1.19e-01 | 5.00e-01 | 0.05410 | -1.34e-02 | 0.052400 | 6.12e-01 | 4.75e-02 |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 47 | 8.21e-01 | 9.44e-01 | 0.05310 | -4.11e-03 | -0.053000 | 9.61e-01 | 5.31e-01 |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 58 | 7.89e-01 | 9.44e-01 | 0.05310 | -4.89e-02 | -0.020600 | 5.20e-01 | 7.86e-01 |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 49 | 8.19e-01 | 9.44e-01 | 0.05230 | -4.32e-03 | -0.052200 | 9.58e-01 | 5.28e-01 |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 96 | 6.90e-01 | 9.18e-01 | 0.05190 | -3.03e-02 | -0.042100 | 6.09e-01 | 4.77e-01 |
| REACTOME ER PHAGOSOME PATHWAY | 48 | 8.32e-01 | 9.44e-01 | 0.05150 | -2.43e-02 | -0.045300 | 7.71e-01 | 5.87e-01 |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 49 | 8.30e-01 | 9.44e-01 | 0.05120 | 2.54e-02 | 0.044400 | 7.59e-01 | 5.91e-01 |
| REACTOME M G1 TRANSITION | 50 | 8.23e-01 | 9.44e-01 | 0.05080 | 5.99e-03 | -0.050400 | 9.42e-01 | 5.38e-01 |
| REACTOME HIV INFECTION | 154 | 5.77e-01 | 8.98e-01 | 0.05000 | 3.95e-02 | 0.030800 | 4.00e-01 | 5.12e-01 |
| REACTOME BASE EXCISION REPAIR | 11 | 9.61e-01 | 9.86e-01 | 0.04960 | 2.70e-02 | 0.041600 | 8.77e-01 | 8.11e-01 |
| REACTOME G ALPHA1213 SIGNALLING EVENTS | 42 | 8.62e-01 | 9.65e-01 | 0.04890 | -4.85e-02 | -0.005790 | 5.87e-01 | 9.48e-01 |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 187 | 5.10e-01 | 8.66e-01 | 0.04870 | 4.13e-02 | -0.025800 | 3.33e-01 | 5.45e-01 |
| REACTOME MRNA 3 END PROCESSING | 31 | 9.05e-01 | 9.69e-01 | 0.04720 | 3.26e-02 | 0.034200 | 7.54e-01 | 7.42e-01 |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 125 | 6.76e-01 | 9.11e-01 | 0.04550 | 1.34e-02 | -0.043500 | 7.96e-01 | 4.03e-01 |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 42 | 8.77e-01 | 9.68e-01 | 0.04540 | 1.18e-02 | -0.043800 | 8.95e-01 | 6.24e-01 |
| REACTOME PI3K AKT ACTIVATION | 31 | 9.15e-01 | 9.69e-01 | 0.04460 | -2.57e-02 | -0.036400 | 8.05e-01 | 7.26e-01 |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 92 | 7.77e-01 | 9.44e-01 | 0.04380 | 3.51e-02 | 0.026200 | 5.62e-01 | 6.65e-01 |
| REACTOME MITOTIC G1 G1 S PHASES | 82 | 7.98e-01 | 9.44e-01 | 0.04320 | -4.27e-02 | -0.006450 | 5.05e-01 | 9.20e-01 |
| REACTOME PI3K EVENTS IN ERBB2 SIGNALING | 32 | 9.26e-01 | 9.69e-01 | 0.03940 | 3.54e-02 | -0.017300 | 7.29e-01 | 8.65e-01 |
| REACTOME RNA POL II TRANSCRIPTION | 85 | 8.20e-01 | 9.44e-01 | 0.03920 | 1.47e-02 | -0.036300 | 8.15e-01 | 5.64e-01 |
| REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | 10 | 9.79e-01 | 9.92e-01 | 0.03780 | -3.75e-02 | 0.004150 | 8.37e-01 | 9.82e-01 |
| REACTOME PHOSPHOLIPID METABOLISM | 113 | 7.83e-01 | 9.44e-01 | 0.03770 | 3.44e-02 | -0.015600 | 5.30e-01 | 7.76e-01 |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 167 | 7.03e-01 | 9.22e-01 | 0.03750 | 1.05e-02 | -0.036000 | 8.15e-01 | 4.25e-01 |
| REACTOME MEMBRANE TRAFFICKING | 94 | 8.61e-01 | 9.65e-01 | 0.03330 | 2.68e-02 | 0.019700 | 6.54e-01 | 7.42e-01 |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 44 | 9.28e-01 | 9.69e-01 | 0.03300 | 2.50e-02 | -0.021600 | 7.74e-01 | 8.05e-01 |
| REACTOME SIGNALING BY WNT | 56 | 9.17e-01 | 9.69e-01 | 0.03280 | -2.47e-02 | -0.021700 | 7.50e-01 | 7.79e-01 |
| REACTOME GAB1 SIGNALOSOME | 32 | 9.54e-01 | 9.85e-01 | 0.03160 | -1.19e-02 | -0.029300 | 9.08e-01 | 7.75e-01 |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 49 | 9.38e-01 | 9.72e-01 | 0.02930 | 7.67e-03 | -0.028200 | 9.26e-01 | 7.33e-01 |
| REACTOME SIGNALING BY ILS | 62 | 9.27e-01 | 9.69e-01 | 0.02910 | -2.58e-02 | -0.013400 | 7.26e-01 | 8.55e-01 |
| REACTOME SIGNALING BY FGFR IN DISEASE | 79 | 9.06e-01 | 9.69e-01 | 0.02870 | -7.19e-03 | 0.027800 | 9.12e-01 | 6.70e-01 |
| REACTOME SYNTHESIS OF DNA | 59 | 9.28e-01 | 9.69e-01 | 0.02870 | 2.15e-02 | -0.019000 | 7.76e-01 | 8.01e-01 |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 96 | 8.96e-01 | 9.69e-01 | 0.02810 | 1.59e-02 | 0.023200 | 7.88e-01 | 6.95e-01 |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 40 | 9.64e-01 | 9.86e-01 | 0.02430 | 1.05e-02 | -0.022000 | 9.09e-01 | 8.10e-01 |
| REACTOME MITOTIC M M G1 PHASES | 92 | 9.28e-01 | 9.69e-01 | 0.02330 | 2.57e-03 | -0.023200 | 9.66e-01 | 7.02e-01 |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 123 | 9.28e-01 | 9.69e-01 | 0.02040 | 1.94e-02 | 0.006340 | 7.11e-01 | 9.04e-01 |
| REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | 37 | 9.78e-01 | 9.92e-01 | 0.02010 | 2.00e-02 | -0.002490 | 8.34e-01 | 9.79e-01 |
| REACTOME SIGNALING BY FGFR | 67 | 9.63e-01 | 9.86e-01 | 0.01930 | -5.47e-03 | 0.018500 | 9.38e-01 | 7.94e-01 |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 274 | 9.00e-01 | 9.69e-01 | 0.01650 | -8.21e-03 | -0.014300 | 8.17e-01 | 6.87e-01 |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 333 | 8.81e-01 | 9.69e-01 | 0.01630 | 3.51e-03 | 0.015900 | 9.13e-01 | 6.21e-01 |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 43 | 9.83e-01 | 9.92e-01 | 0.01600 | 1.13e-02 | -0.011300 | 8.98e-01 | 8.98e-01 |
| REACTOME APOPTOSIS | 94 | 9.67e-01 | 9.87e-01 | 0.01570 | 1.42e-02 | 0.006750 | 8.13e-01 | 9.10e-01 |
| REACTOME DNA REPLICATION | 102 | 9.64e-01 | 9.86e-01 | 0.01520 | 9.48e-03 | -0.011900 | 8.69e-01 | 8.36e-01 |
| REACTOME MRNA PROCESSING | 137 | 9.55e-01 | 9.85e-01 | 0.01520 | 1.51e-02 | 0.000991 | 7.61e-01 | 9.84e-01 |
| REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 70 | 9.82e-01 | 9.92e-01 | 0.01280 | 6.70e-03 | -0.011000 | 9.23e-01 | 8.74e-01 |
| REACTOME TRANSCRIPTION | 125 | 9.79e-01 | 9.92e-01 | 0.01080 | -9.81e-03 | -0.004600 | 8.50e-01 | 9.30e-01 |
| REACTOME S PHASE | 69 | 9.90e-01 | 9.96e-01 | 0.01010 | 9.18e-03 | 0.004270 | 8.95e-01 | 9.51e-01 |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 50 | 9.96e-01 | 9.98e-01 | 0.00730 | 6.39e-03 | -0.003530 | 9.38e-01 | 9.66e-01 |
| REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | 55 | 9.97e-01 | 9.98e-01 | 0.00585 | 5.55e-03 | 0.001860 | 9.43e-01 | 9.81e-01 |
| REACTOME MITOTIC PROMETAPHASE | 41 | 9.98e-01 | 9.98e-01 | 0.00567 | -2.78e-03 | -0.004940 | 9.75e-01 | 9.56e-01 |
Detailed Gene set reports
REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 1.23e-10 |
| p.adjustMANOVA | 8.01e-09 |
| s.dist | 1.11 |
| s.Sed | 0.555 |
| s.Ex | -0.959 |
| p.Sed | 0.000873 |
| p.Ex | 8.71e-09 |
| Gene | Sed | Ex |
|---|---|---|
| Atp5a1 | 4579 | -4356 |
| Atp5b | 4271 | -4353 |
| Atp5e | 4304 | -4258 |
| Atp5g1 | 4005 | -4432 |
| Atp5k | 3878 | -4428 |
| Atp5d | 4105 | -3683 |
| Atp5j | 3260 | -4452 |
| Atp5o | 2963 | -4403 |
| Atp5j2 | 1920 | -4456 |
| Atp5h | 1871 | -4437 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Atp5a1 | 4579 | -4356 |
| Atp5b | 4271 | -4353 |
| Atp5c1 | -1288 | -4222 |
| Atp5d | 4105 | -3683 |
| Atp5e | 4304 | -4258 |
| Atp5g1 | 4005 | -4432 |
| Atp5h | 1871 | -4437 |
| Atp5j | 3260 | -4452 |
| Atp5j2 | 1920 | -4456 |
| Atp5k | 3878 | -4428 |
| Atp5l | -3155 | -4438 |
| Atp5o | 2963 | -4403 |
REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 5.1e-13 |
| p.adjustMANOVA | 4.64e-11 |
| s.dist | 0.983 |
| s.Sed | 0.391 |
| s.Ex | -0.902 |
| p.Sed | 0.00315 |
| p.Ex | 9.83e-12 |
| Gene | Sed | Ex |
|---|---|---|
| Aco2 | 4576 | -4220 |
| Mdh2 | 4505 | -4175 |
| Idh3g | 4542 | -4069 |
| Sdha | 4123 | -4398 |
| Cs | 4410 | -3960 |
| Dlst | 4246 | -3883 |
| Sdhc | 3278 | -4391 |
| Idh3a | 3147 | -4279 |
| Sdhd | 3380 | -3632 |
| Suclg2 | 3041 | -3744 |
| Suclg1 | 2714 | -2968 |
| Idh3b | 1756 | -4435 |
| Ogdh | 1921 | -3401 |
| Sucla2 | 1069 | -4114 |
| Fh1 | 878 | -4255 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 4576 | -4220 |
| Cs | 4410 | -3960 |
| Dld | -1379 | -4321 |
| Dlst | 4246 | -3883 |
| Fh1 | 878 | -4255 |
| Idh2 | -4444 | -4514 |
| Idh3a | 3147 | -4279 |
| Idh3b | 1756 | -4435 |
| Idh3g | 4542 | -4069 |
| Mdh2 | 4505 | -4175 |
| Nnt | -4292 | -3935 |
| Ogdh | 1921 | -3401 |
| Sdha | 4123 | -4398 |
| Sdhb | -3089 | -4482 |
| Sdhc | 3278 | -4391 |
| Sdhd | 3380 | -3632 |
| Sucla2 | 1069 | -4114 |
| Suclg1 | 2714 | -2968 |
| Suclg2 | 3041 | -3744 |
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
| metric | value |
|---|---|
| setSize | 59 |
| pMANOVA | 1.01e-31 |
| p.adjustMANOVA | 1.54e-29 |
| s.dist | 0.893 |
| s.Sed | 0.118 |
| s.Ex | -0.885 |
| p.Sed | 0.116 |
| p.Ex | 4.99e-32 |
| Gene | Sed | Ex |
|---|---|---|
| Uqcr11 | 4172 | -4408 |
| Sdha | 4123 | -4398 |
| Ndufs3 | 4205 | -4250 |
| Cox6b1 | 4132 | -4283 |
| Ndufs2 | 4159 | -4213 |
| Ndufa8 | 3955 | -4039 |
| Cox4i1 | 3581 | -4373 |
| Uqcrc1 | 3692 | -4229 |
| Ndufv3 | 4011 | -3863 |
| Ndufa13 | 4389 | -3436 |
| Ndufa1 | 3348 | -4346 |
| Sdhc | 3278 | -4391 |
| Ndufa7 | 4298 | -3174 |
| Ndufa10 | 3357 | -4028 |
| Ndufs1 | 3101 | -4307 |
| Ndufa9 | 2917 | -4400 |
| Sdhd | 3380 | -3632 |
| Uqcrfs1 | 2595 | -4399 |
| Ndufb6 | 4259 | -2503 |
| Ndufs7 | 2616 | -3994 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Cox4i1 | 3581 | -4373 |
| Cox5a | 1357 | -4389 |
| Cox6a1 | -4434 | -905 |
| Cox6b1 | 4132 | -4283 |
| Cox6c | -4441 | -4405 |
| Cox7a2l | -2532 | 1635 |
| Cox7c | -2615 | -4357 |
| Cox8a | -4390 | -4143 |
| Cyc1 | 1294 | -4306 |
| Cycs | -4344 | -3998 |
| Etfa | -3050 | -4440 |
| Etfb | -1093 | -4284 |
| Etfdh | -2662 | -4471 |
| Ndufa1 | 3348 | -4346 |
| Ndufa10 | 3357 | -4028 |
| Ndufa11 | 1101 | -4217 |
| Ndufa12 | -1142 | -4272 |
| Ndufa13 | 4389 | -3436 |
| Ndufa2 | -1021 | -4070 |
| Ndufa3 | 2206 | -4235 |
| Ndufa4 | -4245 | -4424 |
| Ndufa5 | -4284 | -4354 |
| Ndufa6 | -1279 | -4341 |
| Ndufa7 | 4298 | -3174 |
| Ndufa8 | 3955 | -4039 |
| Ndufa9 | 2917 | -4400 |
| Ndufab1 | -2180 | -4455 |
| Ndufb10 | 1603 | -4206 |
| Ndufb2 | -494 | -4120 |
| Ndufb3 | -1156 | -4303 |
| Ndufb4 | -3277 | -3751 |
| Ndufb5 | 601 | -4047 |
| Ndufb6 | 4259 | -2503 |
| Ndufb7 | -2070 | -3367 |
| Ndufb9 | -1127 | -4386 |
| Ndufc1 | -207 | -3504 |
| Ndufc2 | -816 | -3497 |
| Ndufs1 | 3101 | -4307 |
| Ndufs2 | 4159 | -4213 |
| Ndufs3 | 4205 | -4250 |
| Ndufs4 | 2238 | -4187 |
| Ndufs5 | 1002 | -3691 |
| Ndufs6 | 3006 | -3130 |
| Ndufs7 | 2616 | -3994 |
| Ndufs8 | 1170 | -4300 |
| Ndufv1 | 1289 | -4240 |
| Ndufv2 | -2993 | -4418 |
| Ndufv3 | 4011 | -3863 |
| Sdha | 4123 | -4398 |
| Sdhb | -3089 | -4482 |
| Sdhc | 3278 | -4391 |
| Sdhd | 3380 | -3632 |
| Uqcr11 | 4172 | -4408 |
| Uqcrb | -300 | -4298 |
| Uqcrc1 | 3692 | -4229 |
| Uqcrc2 | 1989 | -4430 |
| Uqcrfs1 | 2595 | -4399 |
| Uqcrh | 75 | -4247 |
| Uqcrq | -311 | -4384 |
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
| metric | value |
|---|---|
| setSize | 73 |
| pMANOVA | 1.81e-38 |
| p.adjustMANOVA | 4.12e-36 |
| s.dist | 0.883 |
| s.Sed | 0.189 |
| s.Ex | -0.863 |
| p.Sed | 0.00533 |
| p.Ex | 2.31e-37 |
| Gene | Sed | Ex |
|---|---|---|
| Atp5a1 | 4579 | -4356 |
| Atp5b | 4271 | -4353 |
| Uqcr11 | 4172 | -4408 |
| Atp5e | 4304 | -4258 |
| Sdha | 4123 | -4398 |
| Ndufs3 | 4205 | -4250 |
| Atp5g1 | 4005 | -4432 |
| Cox6b1 | 4132 | -4283 |
| Ndufs2 | 4159 | -4213 |
| Atp5k | 3878 | -4428 |
| Ndufa8 | 3955 | -4039 |
| Cox4i1 | 3581 | -4373 |
| Uqcrc1 | 3692 | -4229 |
| Ndufv3 | 4011 | -3863 |
| Atp5d | 4105 | -3683 |
| Ndufa13 | 4389 | -3436 |
| Ndufa1 | 3348 | -4346 |
| Atp5j | 3260 | -4452 |
| Sdhc | 3278 | -4391 |
| Ndufa7 | 4298 | -3174 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Atp5a1 | 4579 | -4356 |
| Atp5b | 4271 | -4353 |
| Atp5c1 | -1288 | -4222 |
| Atp5d | 4105 | -3683 |
| Atp5e | 4304 | -4258 |
| Atp5g1 | 4005 | -4432 |
| Atp5h | 1871 | -4437 |
| Atp5j | 3260 | -4452 |
| Atp5j2 | 1920 | -4456 |
| Atp5k | 3878 | -4428 |
| Atp5l | -3155 | -4438 |
| Atp5o | 2963 | -4403 |
| Cox4i1 | 3581 | -4373 |
| Cox5a | 1357 | -4389 |
| Cox6a1 | -4434 | -905 |
| Cox6b1 | 4132 | -4283 |
| Cox6c | -4441 | -4405 |
| Cox7a2l | -2532 | 1635 |
| Cox7c | -2615 | -4357 |
| Cox8a | -4390 | -4143 |
| Cyc1 | 1294 | -4306 |
| Cycs | -4344 | -3998 |
| Etfa | -3050 | -4440 |
| Etfb | -1093 | -4284 |
| Etfdh | -2662 | -4471 |
| Ndufa1 | 3348 | -4346 |
| Ndufa10 | 3357 | -4028 |
| Ndufa11 | 1101 | -4217 |
| Ndufa12 | -1142 | -4272 |
| Ndufa13 | 4389 | -3436 |
| Ndufa2 | -1021 | -4070 |
| Ndufa3 | 2206 | -4235 |
| Ndufa4 | -4245 | -4424 |
| Ndufa5 | -4284 | -4354 |
| Ndufa6 | -1279 | -4341 |
| Ndufa7 | 4298 | -3174 |
| Ndufa8 | 3955 | -4039 |
| Ndufa9 | 2917 | -4400 |
| Ndufab1 | -2180 | -4455 |
| Ndufb10 | 1603 | -4206 |
| Ndufb2 | -494 | -4120 |
| Ndufb3 | -1156 | -4303 |
| Ndufb4 | -3277 | -3751 |
| Ndufb5 | 601 | -4047 |
| Ndufb6 | 4259 | -2503 |
| Ndufb7 | -2070 | -3367 |
| Ndufb9 | -1127 | -4386 |
| Ndufc1 | -207 | -3504 |
| Ndufc2 | -816 | -3497 |
| Ndufs1 | 3101 | -4307 |
| Ndufs2 | 4159 | -4213 |
| Ndufs3 | 4205 | -4250 |
| Ndufs4 | 2238 | -4187 |
| Ndufs5 | 1002 | -3691 |
| Ndufs6 | 3006 | -3130 |
| Ndufs7 | 2616 | -3994 |
| Ndufs8 | 1170 | -4300 |
| Ndufv1 | 1289 | -4240 |
| Ndufv2 | -2993 | -4418 |
| Ndufv3 | 4011 | -3863 |
| Sdha | 4123 | -4398 |
| Sdhb | -3089 | -4482 |
| Sdhc | 3278 | -4391 |
| Sdhd | 3380 | -3632 |
| Ucp2 | -2640 | 3168 |
| Ucp3 | 3132 | 1002 |
| Uqcr11 | 4172 | -4408 |
| Uqcrb | -300 | -4298 |
| Uqcrc1 | 3692 | -4229 |
| Uqcrc2 | 1989 | -4430 |
| Uqcrfs1 | 2595 | -4399 |
| Uqcrh | 75 | -4247 |
| Uqcrq | -311 | -4384 |
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
| metric | value |
|---|---|
| setSize | 107 |
| pMANOVA | 3.05e-52 |
| p.adjustMANOVA | 1.39e-49 |
| s.dist | 0.852 |
| s.Sed | 0.203 |
| s.Ex | -0.827 |
| p.Sed | 0.000297 |
| p.Ex | 1.04e-49 |
| Gene | Sed | Ex |
|---|---|---|
| Atp5a1 | 4579 | -4356 |
| Aco2 | 4576 | -4220 |
| Mdh2 | 4505 | -4175 |
| Atp5b | 4271 | -4353 |
| Idh3g | 4542 | -4069 |
| Uqcr11 | 4172 | -4408 |
| Atp5e | 4304 | -4258 |
| Sdha | 4123 | -4398 |
| Ndufs3 | 4205 | -4250 |
| Atp5g1 | 4005 | -4432 |
| Cox6b1 | 4132 | -4283 |
| Ndufs2 | 4159 | -4213 |
| Cs | 4410 | -3960 |
| Atp5k | 3878 | -4428 |
| Dlst | 4246 | -3883 |
| Ndufa8 | 3955 | -4039 |
| Cox4i1 | 3581 | -4373 |
| Uqcrc1 | 3692 | -4229 |
| Ndufv3 | 4011 | -3863 |
| Atp5d | 4105 | -3683 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 4576 | -4220 |
| Adhfe1 | -1240 | -4349 |
| Atp5a1 | 4579 | -4356 |
| Atp5b | 4271 | -4353 |
| Atp5c1 | -1288 | -4222 |
| Atp5d | 4105 | -3683 |
| Atp5e | 4304 | -4258 |
| Atp5g1 | 4005 | -4432 |
| Atp5h | 1871 | -4437 |
| Atp5j | 3260 | -4452 |
| Atp5j2 | 1920 | -4456 |
| Atp5k | 3878 | -4428 |
| Atp5l | -3155 | -4438 |
| Atp5o | 2963 | -4403 |
| Bsg | 1383 | -3945 |
| Cox4i1 | 3581 | -4373 |
| Cox5a | 1357 | -4389 |
| Cox6a1 | -4434 | -905 |
| Cox6b1 | 4132 | -4283 |
| Cox6c | -4441 | -4405 |
| Cox7a2l | -2532 | 1635 |
| Cox7c | -2615 | -4357 |
| Cox8a | -4390 | -4143 |
| Cs | 4410 | -3960 |
| Cyc1 | 1294 | -4306 |
| Cycs | -4344 | -3998 |
| D2hgdh | 1444 | -3783 |
| Dlat | 1892 | -4327 |
| Dld | -1379 | -4321 |
| Dlst | 4246 | -3883 |
| Etfa | -3050 | -4440 |
| Etfb | -1093 | -4284 |
| Etfdh | -2662 | -4471 |
| Fh1 | 878 | -4255 |
| Idh1 | -3241 | -4073 |
| Idh2 | -4444 | -4514 |
| Idh3a | 3147 | -4279 |
| Idh3b | 1756 | -4435 |
| Idh3g | 4542 | -4069 |
| L2hgdh | 68 | -742 |
| Ldha | 4475 | -1794 |
| Ldhb | -4506 | -4519 |
| Mdh2 | 4505 | -4175 |
| Ndufa1 | 3348 | -4346 |
| Ndufa10 | 3357 | -4028 |
| Ndufa11 | 1101 | -4217 |
| Ndufa12 | -1142 | -4272 |
| Ndufa13 | 4389 | -3436 |
| Ndufa2 | -1021 | -4070 |
| Ndufa3 | 2206 | -4235 |
| Ndufa4 | -4245 | -4424 |
| Ndufa5 | -4284 | -4354 |
| Ndufa6 | -1279 | -4341 |
| Ndufa7 | 4298 | -3174 |
| Ndufa8 | 3955 | -4039 |
| Ndufa9 | 2917 | -4400 |
| Ndufab1 | -2180 | -4455 |
| Ndufb10 | 1603 | -4206 |
| Ndufb2 | -494 | -4120 |
| Ndufb3 | -1156 | -4303 |
| Ndufb4 | -3277 | -3751 |
| Ndufb5 | 601 | -4047 |
| Ndufb6 | 4259 | -2503 |
| Ndufb7 | -2070 | -3367 |
| Ndufb9 | -1127 | -4386 |
| Ndufc1 | -207 | -3504 |
| Ndufc2 | -816 | -3497 |
| Ndufs1 | 3101 | -4307 |
| Ndufs2 | 4159 | -4213 |
| Ndufs3 | 4205 | -4250 |
| Ndufs4 | 2238 | -4187 |
| Ndufs5 | 1002 | -3691 |
| Ndufs6 | 3006 | -3130 |
| Ndufs7 | 2616 | -3994 |
| Ndufs8 | 1170 | -4300 |
| Ndufv1 | 1289 | -4240 |
| Ndufv2 | -2993 | -4418 |
| Ndufv3 | 4011 | -3863 |
| Nnt | -4292 | -3935 |
| Ogdh | 1921 | -3401 |
| Pdha1 | 3140 | -4451 |
| Pdhb | -2283 | -4397 |
| Pdhx | 4338 | -3249 |
| Pdk1 | -1906 | -4122 |
| Pdk2 | 3920 | -2055 |
| Pdk4 | -3024 | -4414 |
| Pdp1 | 2017 | -32 |
| Pdp2 | 848 | 2015 |
| Pdpr | -926 | -3700 |
| Sdha | 4123 | -4398 |
| Sdhb | -3089 | -4482 |
| Sdhc | 3278 | -4391 |
| Sdhd | 3380 | -3632 |
| Slc16a1 | 223 | -4439 |
| Slc16a3 | 3016 | 4172 |
| Sucla2 | 1069 | -4114 |
| Suclg1 | 2714 | -2968 |
| Suclg2 | 3041 | -3744 |
| Ucp2 | -2640 | 3168 |
| Ucp3 | 3132 | 1002 |
| Uqcr11 | 4172 | -4408 |
| Uqcrb | -300 | -4298 |
| Uqcrc1 | 3692 | -4229 |
| Uqcrc2 | 1989 | -4430 |
| Uqcrfs1 | 2595 | -4399 |
| Uqcrh | 75 | -4247 |
| Uqcrq | -311 | -4384 |
REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 2.72e-06 |
| p.adjustMANOVA | 0.000124 |
| s.dist | 0.801 |
| s.Sed | 0.293 |
| s.Ex | -0.745 |
| p.Sed | 0.0677 |
| p.Ex | 3.27e-06 |
| Gene | Sed | Ex |
|---|---|---|
| Hadha | 3895 | -4454 |
| Hadh | 3415 | -4466 |
| Acadl | 3340 | -4498 |
| Acadvl | 797 | -4446 |
| Echs1 | 777 | -4249 |
| Acads | 4139 | -605 |
| Acadm | 192 | -4448 |
| Pcca | 4430 | -30 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Acadl | 3340 | -4498 |
| Acadm | 192 | -4448 |
| Acads | 4139 | -605 |
| Acadvl | 797 | -4446 |
| Decr1 | -2328 | -4329 |
| Echs1 | 777 | -4249 |
| Eci1 | -4512 | -4436 |
| Hadh | 3415 | -4466 |
| Hadha | 3895 | -4454 |
| Hadhb | -81 | -4479 |
| Mcee | -247 | -3759 |
| Pcca | 4430 | -30 |
| Pccb | 3850 | 666 |
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
| metric | value |
|---|---|
| setSize | 38 |
| pMANOVA | 6.77e-17 |
| p.adjustMANOVA | 7.7e-15 |
| s.dist | 0.8 |
| s.Sed | 0.25 |
| s.Ex | -0.76 |
| p.Sed | 0.00782 |
| p.Ex | 5.17e-16 |
| Gene | Sed | Ex |
|---|---|---|
| Aco2 | 4576 | -4220 |
| Mdh2 | 4505 | -4175 |
| Idh3g | 4542 | -4069 |
| Sdha | 4123 | -4398 |
| Cs | 4410 | -3960 |
| Dlst | 4246 | -3883 |
| Sdhc | 3278 | -4391 |
| Pdhx | 4338 | -3249 |
| Pdha1 | 3140 | -4451 |
| Idh3a | 3147 | -4279 |
| Sdhd | 3380 | -3632 |
| Suclg2 | 3041 | -3744 |
| Dlat | 1892 | -4327 |
| Pdk2 | 3920 | -2055 |
| Suclg1 | 2714 | -2968 |
| Ldha | 4475 | -1794 |
| Idh3b | 1756 | -4435 |
| Ogdh | 1921 | -3401 |
| D2hgdh | 1444 | -3783 |
| Bsg | 1383 | -3945 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 4576 | -4220 |
| Adhfe1 | -1240 | -4349 |
| Bsg | 1383 | -3945 |
| Cs | 4410 | -3960 |
| D2hgdh | 1444 | -3783 |
| Dlat | 1892 | -4327 |
| Dld | -1379 | -4321 |
| Dlst | 4246 | -3883 |
| Fh1 | 878 | -4255 |
| Idh1 | -3241 | -4073 |
| Idh2 | -4444 | -4514 |
| Idh3a | 3147 | -4279 |
| Idh3b | 1756 | -4435 |
| Idh3g | 4542 | -4069 |
| L2hgdh | 68 | -742 |
| Ldha | 4475 | -1794 |
| Ldhb | -4506 | -4519 |
| Mdh2 | 4505 | -4175 |
| Nnt | -4292 | -3935 |
| Ogdh | 1921 | -3401 |
| Pdha1 | 3140 | -4451 |
| Pdhb | -2283 | -4397 |
| Pdhx | 4338 | -3249 |
| Pdk1 | -1906 | -4122 |
| Pdk2 | 3920 | -2055 |
| Pdk4 | -3024 | -4414 |
| Pdp1 | 2017 | -32 |
| Pdp2 | 848 | 2015 |
| Pdpr | -926 | -3700 |
| Sdha | 4123 | -4398 |
| Sdhb | -3089 | -4482 |
| Sdhc | 3278 | -4391 |
| Sdhd | 3380 | -3632 |
| Slc16a1 | 223 | -4439 |
| Slc16a3 | 3016 | 4172 |
| Sucla2 | 1069 | -4114 |
| Suclg1 | 2714 | -2968 |
| Suclg2 | 3041 | -3744 |
REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 7.58e-05 |
| p.adjustMANOVA | 0.00215 |
| s.dist | 0.771 |
| s.Sed | 0.613 |
| s.Ex | 0.468 |
| p.Sed | 0.00043 |
| p.Ex | 0.00725 |
| Gene | Sed | Ex |
|---|---|---|
| Phka1 | 4580 | 4576 |
| Pygm | 4593 | 4507 |
| Agl | 4326 | 4283 |
| Phkg1 | 4066 | 4440 |
| Calm1 | 4582 | 3685 |
| Pgm1 | 4482 | 3569 |
| Phkb | 4318 | 3445 |
| Phkg2 | 3154 | 2022 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agl | 4326 | 4283 |
| Calm1 | 4582 | 3685 |
| Gyg | 4017 | -2789 |
| Pgm1 | 4482 | 3569 |
| Phka1 | 4580 | 4576 |
| Phka2 | -3801 | -1125 |
| Phkb | 4318 | 3445 |
| Phkg1 | 4066 | 4440 |
| Phkg2 | 3154 | 2022 |
| Pygb | -3233 | -2394 |
| Pygm | 4593 | 4507 |
REACTOME_COMPLEMENT_CASCADE
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000112 |
| p.adjustMANOVA | 0.00301 |
| s.dist | 0.729 |
| s.Sed | -0.505 |
| s.Ex | 0.526 |
| p.Sed | 0.00373 |
| p.Ex | 0.00251 |
| Gene | Sed | Ex |
|---|---|---|
| Cfd | -4537 | 4639 |
| C4b | -4518 | 4484 |
| C3 | -4307 | 4597 |
| C1qa | -4290 | 4145 |
| C7 | -1580 | 2751 |
| C1s1 | -2652 | 535 |
| C1qb | -47 | 3496 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| C1qa | -4290 | 4145 |
| C1qb | -47 | 3496 |
| C1qc | 2919 | 4563 |
| C1s1 | -2652 | 535 |
| C3 | -4307 | 4597 |
| C4b | -4518 | 4484 |
| C7 | -1580 | 2751 |
| Cd46 | 684 | 1234 |
| Cfd | -4537 | 4639 |
| Cr1l | -4165 | -1949 |
| Pros1 | -2718 | -1326 |
REACTOME_NCAM1_INTERACTIONS
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 5.25e-06 |
| p.adjustMANOVA | 0.000217 |
| s.dist | 0.706 |
| s.Sed | -0.15 |
| s.Ex | 0.69 |
| p.Sed | 0.3 |
| p.Ex | 1.74e-06 |
| Gene | Sed | Ex |
|---|---|---|
| Col3a1 | -4528 | 4636 |
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Col6a3 | -2517 | 4530 |
| Col6a1 | -2154 | 4599 |
| Col4a1 | -2257 | 4124 |
| Prnp | -1805 | 4522 |
| Col5a2 | -1688 | 4621 |
| Col5a1 | -822 | 4462 |
| Gfra1 | -2469 | 885 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agrn | 4040 | 4011 |
| Cacna1s | 3855 | -1985 |
| Cacnb1 | 4560 | 3621 |
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Col3a1 | -4528 | 4636 |
| Col4a1 | -2257 | 4124 |
| Col4a2 | 1752 | 2207 |
| Col5a1 | -822 | 4462 |
| Col5a2 | -1688 | 4621 |
| Col6a1 | -2154 | 4599 |
| Col6a2 | 3285 | 4582 |
| Col6a3 | -2517 | 4530 |
| Gfra1 | -2469 | 885 |
| Nrtn | -2737 | -2518 |
| Prnp | -1805 | 4522 |
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000418 |
| p.adjustMANOVA | 0.00865 |
| s.dist | 0.682 |
| s.Sed | 0.128 |
| s.Ex | -0.67 |
| p.Sed | 0.464 |
| p.Ex | 0.000119 |
| Gene | Sed | Ex |
|---|---|---|
| Pdhx | 4338 | -3249 |
| Pdha1 | 3140 | -4451 |
| Dlat | 1892 | -4327 |
| Pdk2 | 3920 | -2055 |
| Pdp1 | 2017 | -32 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Dlat | 1892 | -4327 |
| Dld | -1379 | -4321 |
| Pdha1 | 3140 | -4451 |
| Pdhb | -2283 | -4397 |
| Pdhx | 4338 | -3249 |
| Pdk1 | -1906 | -4122 |
| Pdk2 | 3920 | -2055 |
| Pdk4 | -3024 | -4414 |
| Pdp1 | 2017 | -32 |
| Pdp2 | 848 | 2015 |
| Pdpr | -926 | -3700 |
REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
| metric | value |
|---|---|
| setSize | 42 |
| pMANOVA | 7.29e-13 |
| p.adjustMANOVA | 5.53e-11 |
| s.dist | 0.662 |
| s.Sed | 0.127 |
| s.Ex | -0.65 |
| p.Sed | 0.156 |
| p.Ex | 3.21e-13 |
| Gene | Sed | Ex |
|---|---|---|
| Atp5a1 | 4579 | -4356 |
| Aco2 | 4576 | -4220 |
| Slc25a12 | 4526 | -4191 |
| Atp5b | 4271 | -4353 |
| Idh3g | 4542 | -4069 |
| Atp5g1 | 4005 | -4432 |
| Cs | 4410 | -3960 |
| Vdac1 | 3637 | -3887 |
| Ldhd | 2947 | -3948 |
| Samm50 | 2793 | -4072 |
| Tomm7 | 2832 | -3888 |
| Timm23 | 2645 | -4111 |
| Timm8a1 | 2609 | -4141 |
| Slc25a4 | 2210 | -4231 |
| Dnajc19 | 2444 | -3511 |
| Timm17a | 2075 | -3344 |
| Timm9 | 1500 | -3924 |
| Cyc1 | 1294 | -4306 |
| Coq2 | 2219 | -2257 |
| Tomm40 | 808 | -3697 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Aco2 | 4576 | -4220 |
| Atp5a1 | 4579 | -4356 |
| Atp5b | 4271 | -4353 |
| Atp5g1 | 4005 | -4432 |
| Bcs1l | -3252 | -3073 |
| Coq2 | 2219 | -2257 |
| Cs | 4410 | -3960 |
| Cyc1 | 1294 | -4306 |
| Dnajc19 | 2444 | -3511 |
| Fxn | 1386 | 3827 |
| Gfer | 3427 | 289 |
| Grpel1 | 2187 | -1226 |
| Grpel2 | -3833 | -2955 |
| Hscb | -1014 | -4087 |
| Hspa9 | -2054 | -4382 |
| Hspd1 | -3398 | -4411 |
| Idh3g | 4542 | -4069 |
| Ldhd | 2947 | -3948 |
| Mtx1 | -3073 | -1444 |
| Mtx2 | -3976 | -3841 |
| Pmpca | -3824 | -3079 |
| Pmpcb | -1949 | -3563 |
| Samm50 | 2793 | -4072 |
| Slc25a12 | 4526 | -4191 |
| Slc25a4 | 2210 | -4231 |
| Timm10 | -4209 | -3903 |
| Timm13 | 41 | -2210 |
| Timm17a | 2075 | -3344 |
| Timm17b | -2895 | 3522 |
| Timm22 | -2464 | 2458 |
| Timm23 | 2645 | -4111 |
| Timm44 | -785 | -3911 |
| Timm50 | -729 | -2172 |
| Timm8a1 | 2609 | -4141 |
| Timm8b | -3217 | -2393 |
| Timm9 | 1500 | -3924 |
| Tomm20 | -3882 | -3505 |
| Tomm22 | 2598 | 801 |
| Tomm40 | 808 | -3697 |
| Tomm5 | -920 | -3711 |
| Tomm7 | 2832 | -3888 |
| Vdac1 | 3637 | -3887 |
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 7.87e-10 |
| p.adjustMANOVA | 4.48e-08 |
| s.dist | 0.653 |
| s.Sed | -0.245 |
| s.Ex | 0.605 |
| p.Sed | 0.0166 |
| p.Ex | 3.11e-09 |
| Gene | Sed | Ex |
|---|---|---|
| Col3a1 | -4528 | 4636 |
| Col1a1 | -3831 | 4630 |
| Timp2 | -3837 | 4202 |
| Col22a1 | -3507 | 4541 |
| Bmp1 | -3826 | 4154 |
| Col1a2 | -3332 | 4583 |
| Adamts2 | -3691 | 3098 |
| Col6a3 | -2517 | 4530 |
| Col6a1 | -2154 | 4599 |
| Mmp14 | -2386 | 4082 |
| Col4a1 | -2257 | 4124 |
| Mmp2 | -3364 | 2509 |
| Pcolce | -2407 | 3498 |
| Pcolce2 | -2414 | 3471 |
| Col5a2 | -1688 | 4621 |
| Col14a1 | -1732 | 3126 |
| Col24a1 | -1646 | 2798 |
| Col5a1 | -822 | 4462 |
| Plod3 | -2800 | 408 |
| Furin | -222 | 4133 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adamts2 | -3691 | 3098 |
| Bmp1 | -3826 | 4154 |
| Col11a2 | 437 | 4358 |
| Col14a1 | -1732 | 3126 |
| Col15a1 | 1151 | -1788 |
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Col22a1 | -3507 | 4541 |
| Col24a1 | -1646 | 2798 |
| Col3a1 | -4528 | 4636 |
| Col4a1 | -2257 | 4124 |
| Col4a2 | 1752 | 2207 |
| Col5a1 | -822 | 4462 |
| Col5a2 | -1688 | 4621 |
| Col5a3 | 1013 | 4106 |
| Col6a1 | -2154 | 4599 |
| Col6a2 | 3285 | 4582 |
| Col6a3 | -2517 | 4530 |
| Col7a1 | 4504 | 4605 |
| Crtap | -2591 | -1519 |
| Furin | -222 | 4133 |
| Mmp14 | -2386 | 4082 |
| Mmp15 | 232 | 3028 |
| Mmp2 | -3364 | 2509 |
| P4hb | 2193 | 34 |
| Pcolce | -2407 | 3498 |
| Pcolce2 | -2414 | 3471 |
| Plod1 | 4181 | -2579 |
| Plod3 | -2800 | 408 |
| Ppib | -2029 | -2223 |
| Serpinh1 | 3663 | -602 |
| Timp2 | -3837 | 4202 |
REACTOME_PYRUVATE_METABOLISM
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 6.86e-05 |
| p.adjustMANOVA | 0.00208 |
| s.dist | 0.627 |
| s.Sed | 0.149 |
| s.Ex | -0.609 |
| p.Sed | 0.302 |
| p.Ex | 2.48e-05 |
| Gene | Sed | Ex |
|---|---|---|
| Pdhx | 4338 | -3249 |
| Pdha1 | 3140 | -4451 |
| Dlat | 1892 | -4327 |
| Pdk2 | 3920 | -2055 |
| Ldha | 4475 | -1794 |
| Bsg | 1383 | -3945 |
| Slc16a1 | 223 | -4439 |
| Pdp1 | 2017 | -32 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Bsg | 1383 | -3945 |
| Dlat | 1892 | -4327 |
| Dld | -1379 | -4321 |
| Ldha | 4475 | -1794 |
| Ldhb | -4506 | -4519 |
| Pdha1 | 3140 | -4451 |
| Pdhb | -2283 | -4397 |
| Pdhx | 4338 | -3249 |
| Pdk1 | -1906 | -4122 |
| Pdk2 | 3920 | -2055 |
| Pdk4 | -3024 | -4414 |
| Pdp1 | 2017 | -32 |
| Pdp2 | 848 | 2015 |
| Pdpr | -926 | -3700 |
| Slc16a1 | 223 | -4439 |
| Slc16a3 | 3016 | 4172 |
REACTOME_COLLAGEN_FORMATION
| metric | value |
|---|---|
| setSize | 27 |
| pMANOVA | 1.86e-07 |
| p.adjustMANOVA | 9.39e-06 |
| s.dist | 0.612 |
| s.Sed | -0.212 |
| s.Ex | 0.574 |
| p.Sed | 0.0571 |
| p.Ex | 2.45e-07 |
| Gene | Sed | Ex |
|---|---|---|
| Col3a1 | -4528 | 4636 |
| Col1a1 | -3831 | 4630 |
| Col22a1 | -3507 | 4541 |
| Bmp1 | -3826 | 4154 |
| Col1a2 | -3332 | 4583 |
| Adamts2 | -3691 | 3098 |
| Col6a3 | -2517 | 4530 |
| Col6a1 | -2154 | 4599 |
| Col4a1 | -2257 | 4124 |
| Pcolce | -2407 | 3498 |
| Pcolce2 | -2414 | 3471 |
| Col5a2 | -1688 | 4621 |
| Col14a1 | -1732 | 3126 |
| Col24a1 | -1646 | 2798 |
| Col5a1 | -822 | 4462 |
| Plod3 | -2800 | 408 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adamts2 | -3691 | 3098 |
| Bmp1 | -3826 | 4154 |
| Col11a2 | 437 | 4358 |
| Col14a1 | -1732 | 3126 |
| Col15a1 | 1151 | -1788 |
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Col22a1 | -3507 | 4541 |
| Col24a1 | -1646 | 2798 |
| Col3a1 | -4528 | 4636 |
| Col4a1 | -2257 | 4124 |
| Col4a2 | 1752 | 2207 |
| Col5a1 | -822 | 4462 |
| Col5a2 | -1688 | 4621 |
| Col5a3 | 1013 | 4106 |
| Col6a1 | -2154 | 4599 |
| Col6a2 | 3285 | 4582 |
| Col6a3 | -2517 | 4530 |
| Col7a1 | 4504 | 4605 |
| Crtap | -2591 | -1519 |
| P4hb | 2193 | 34 |
| Pcolce | -2407 | 3498 |
| Pcolce2 | -2414 | 3471 |
| Plod1 | 4181 | -2579 |
| Plod3 | -2800 | 408 |
| Ppib | -2029 | -2223 |
| Serpinh1 | 3663 | -602 |
REACTOME_GLUCONEOGENESIS
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 3.36e-05 |
| p.adjustMANOVA | 0.00118 |
| s.dist | 0.61 |
| s.Sed | 0.561 |
| s.Ex | -0.24 |
| p.Sed | 3.84e-05 |
| p.Ex | 0.0778 |
| Gene | Sed | Ex |
|---|---|---|
| Got2 | 4306 | -4413 |
| Slc25a12 | 4526 | -4191 |
| Mdh2 | 4505 | -4175 |
| Pgam2 | 3146 | -2898 |
| Mdh1 | 1408 | -4486 |
| Got1 | 1234 | -4485 |
| Pgk1 | 4540 | -620 |
| Fbp2 | 1144 | -1977 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Eno1 | 1645 | 4252 |
| Eno3 | 4566 | 1120 |
| Fbp2 | 1144 | -1977 |
| Got1 | 1234 | -4485 |
| Got2 | 4306 | -4413 |
| Gpi1 | 4570 | 3787 |
| Mdh1 | 1408 | -4486 |
| Mdh2 | 4505 | -4175 |
| Pcx | 3841 | 883 |
| Pfkfb1 | 3251 | 162 |
| Pgam1 | 1492 | 161 |
| Pgam2 | 3146 | -2898 |
| Pgk1 | 4540 | -620 |
| Prkaca | -2139 | 1766 |
| Prkacb | 1802 | 153 |
| Slc25a11 | -789 | -4262 |
| Slc25a12 | 4526 | -4191 |
| Tpi1 | 3450 | 553 |
REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00754 |
| p.adjustMANOVA | 0.0837 |
| s.dist | 0.55 |
| s.Sed | -0.164 |
| s.Ex | -0.525 |
| p.Sed | 0.345 |
| p.Ex | 0.0026 |
| Gene | Sed | Ex |
|---|---|---|
| Gnaq | -4218 | -2690 |
| P2ry1 | -2459 | -4415 |
| Gng12 | -2199 | -3786 |
| Gnb4 | -2177 | -2146 |
| Gng11 | -930 | -464 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gna11 | -3535 | 1556 |
| Gnaq | -4218 | -2690 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Mapk14 | 3679 | -270 |
| P2ry1 | -2459 | -4415 |
REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0161 |
| p.adjustMANOVA | 0.159 |
| s.dist | 0.532 |
| s.Sed | -0.245 |
| s.Ex | -0.472 |
| p.Sed | 0.179 |
| p.Ex | 0.0097 |
| Gene | Sed | Ex |
|---|---|---|
| Gnaq | -4218 | -2690 |
| Gng12 | -2199 | -3786 |
| Gnb4 | -2177 | -2146 |
| Gng11 | -930 | -464 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gna11 | -3535 | 1556 |
| Gna13 | -1752 | 36 |
| Gnaq | -4218 | -2690 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0175 |
| p.adjustMANOVA | 0.168 |
| s.dist | 0.501 |
| s.Sed | -0.174 |
| s.Ex | -0.47 |
| p.Sed | 0.318 |
| p.Ex | 0.007 |
| Gene | Sed | Ex |
|---|---|---|
| Gng12 | -2199 | -3786 |
| Gnb4 | -2177 | -2146 |
| Akt3 | -3476 | -830 |
| Pdpk1 | -427 | -2405 |
| Akt1 | -3945 | -178 |
| Gng11 | -930 | -464 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3945 | -178 |
| Akt2 | 842 | 353 |
| Akt3 | -3476 | -830 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Pdpk1 | -427 | -2405 |
REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.00384 |
| p.adjustMANOVA | 0.0545 |
| s.dist | 0.483 |
| s.Sed | -0.0412 |
| s.Ex | -0.481 |
| p.Sed | 0.776 |
| p.Ex | 0.000864 |
| Gene | Sed | Ex |
|---|---|---|
| Hibch | -3967 | -4186 |
| Hibadh | -2808 | -4084 |
| Dld | -1379 | -4321 |
| Mccc2 | -2153 | -2504 |
| Acat1 | -336 | -4477 |
| Acad8 | -569 | -2195 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Acad8 | -569 | -2195 |
| Acadsb | 3161 | -1575 |
| Acat1 | -336 | -4477 |
| Aldh6a1 | 2993 | -3813 |
| Auh | -832 | 3068 |
| Bcat2 | -442 | 1436 |
| Bckdha | 1125 | -3826 |
| Bckdhb | -3393 | 2098 |
| Dbt | 835 | -185 |
| Dld | -1379 | -4321 |
| Hibadh | -2808 | -4084 |
| Hibch | -3967 | -4186 |
| Hsd17b10 | 2263 | -2728 |
| Ivd | 2109 | -3834 |
| Mccc1 | 693 | -3107 |
| Mccc2 | -2153 | -2504 |
REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0337 |
| p.adjustMANOVA | 0.238 |
| s.dist | 0.481 |
| s.Sed | -0.451 |
| s.Ex | -0.167 |
| p.Sed | 0.0136 |
| p.Ex | 0.359 |
| Gene | Sed | Ex |
|---|---|---|
| Fabp4 | -4539 | -4416 |
| Cav1 | -4333 | -4248 |
| Ppp1cb | -3247 | -3611 |
| Mgll | -4372 | -1095 |
| Abhd5 | -3918 | -741 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Abhd5 | -3918 | -741 |
| Cav1 | -4333 | -4248 |
| Fabp4 | -4539 | -4416 |
| Lipe | -2413 | 1883 |
| Mgll | -4372 | -1095 |
| Ppp1ca | -495 | 1257 |
| Ppp1cb | -3247 | -3611 |
| Ppp1cc | 3219 | 2002 |
| Prkaca | -2139 | 1766 |
| Prkacb | 1802 | 153 |
REACTOME_SIGNAL_ATTENUATION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0297 |
| p.adjustMANOVA | 0.233 |
| s.dist | 0.477 |
| s.Sed | -0.417 |
| s.Ex | 0.232 |
| p.Sed | 0.0225 |
| p.Ex | 0.204 |
| Gene | Sed | Ex |
|---|---|---|
| Grb10 | -3331 | 4405 |
| Shc2 | -3293 | 1692 |
| Irs2 | -1297 | 4059 |
| Grb2 | -3855 | 698 |
| Irs1 | -3947 | 407 |
| Mapk3 | -594 | 2518 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Crk | -4206 | -3538 |
| Grb10 | -3331 | 4405 |
| Grb2 | -3855 | 698 |
| Insr | 1370 | 651 |
| Irs1 | -3947 | 407 |
| Irs2 | -1297 | 4059 |
| Mapk3 | -594 | 2518 |
| Shc1 | 638 | 3990 |
| Shc2 | -3293 | 1692 |
| Sos1 | -369 | -3654 |
REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.034 |
| p.adjustMANOVA | 0.238 |
| s.dist | 0.475 |
| s.Sed | 0.00166 |
| s.Ex | -0.475 |
| p.Sed | 0.993 |
| p.Ex | 0.00937 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb1 | 2464 | -3575 |
| Gnai2 | 3716 | -1248 |
| Gng5 | 670 | -4225 |
| Gnb2 | 449 | -2545 |
| Gnb5 | 193 | -3169 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adcy6 | -3979 | -817 |
| Gnai2 | 3716 | -1248 |
| Gnao1 | 2064 | 867 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0185 |
| p.adjustMANOVA | 0.169 |
| s.dist | 0.46 |
| s.Sed | 0.351 |
| s.Ex | 0.297 |
| p.Sed | 0.0284 |
| p.Ex | 0.0634 |
| Gene | Sed | Ex |
|---|---|---|
| Slc3a2 | 4157 | 2590 |
| Slc7a6 | 2226 | 3753 |
| Slc7a2 | 1750 | 4587 |
| Slc38a4 | 4365 | 1729 |
| Slc36a1 | 4397 | 1486 |
| Slc7a8 | 2513 | 2584 |
| Slc38a2 | 1521 | 3718 |
| Slc6a6 | 3788 | 1403 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Slc16a10 | 2752 | -137 |
| Slc1a5 | -4533 | 2325 |
| Slc36a1 | 4397 | 1486 |
| Slc38a2 | 1521 | 3718 |
| Slc38a3 | 1651 | -4292 |
| Slc38a4 | 4365 | 1729 |
| Slc3a2 | 4157 | 2590 |
| Slc43a1 | -2845 | 1590 |
| Slc43a2 | -592 | -2842 |
| Slc6a6 | 3788 | 1403 |
| Slc7a2 | 1750 | 4587 |
| Slc7a6 | 2226 | 3753 |
| Slc7a8 | 2513 | 2584 |
REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0307 |
| p.adjustMANOVA | 0.233 |
| s.dist | 0.447 |
| s.Sed | -0.21 |
| s.Ex | -0.394 |
| p.Sed | 0.207 |
| p.Ex | 0.0182 |
| Gene | Sed | Ex |
|---|---|---|
| Gng12 | -2199 | -3786 |
| Gnb4 | -2177 | -2146 |
| Akt3 | -3476 | -830 |
| Pdpk1 | -427 | -2405 |
| Akt1 | -3945 | -178 |
| Gng11 | -930 | -464 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3945 | -178 |
| Akt2 | 842 | 353 |
| Akt3 | -3476 | -830 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Pdpk1 | -427 | -2405 |
| Plcb3 | -2788 | 2082 |
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.00577 |
| p.adjustMANOVA | 0.0702 |
| s.dist | 0.445 |
| s.Sed | -0.426 |
| s.Ex | 0.13 |
| p.Sed | 0.00237 |
| p.Ex | 0.354 |
| Gene | Sed | Ex |
|---|---|---|
| Rap1b | -3031 | 3218 |
| Fn1 | -3442 | 2688 |
| Ptpn1 | -3287 | 2808 |
| Ptk2 | -2270 | 3409 |
| Csk | -3349 | 1422 |
| Bcar1 | -3720 | 886 |
| Grb2 | -3855 | 698 |
| Vwf | -600 | 973 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3945 | -178 |
| Bcar1 | -3720 | 886 |
| Crk | -4206 | -3538 |
| Csk | -3349 | 1422 |
| Fn1 | -3442 | 2688 |
| Grb2 | -3855 | 698 |
| Pdpk1 | -427 | -2405 |
| Ptk2 | -2270 | 3409 |
| Ptpn1 | -3287 | 2808 |
| Rap1a | -4203 | -2974 |
| Rap1b | -3031 | 3218 |
| Rapgef3 | 1486 | -132 |
| Rasgrp2 | 964 | 1546 |
| Shc1 | 638 | 3990 |
| Sos1 | -369 | -3654 |
| Tln1 | 829 | 2398 |
| Vwf | -600 | 973 |
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.00602 |
| p.adjustMANOVA | 0.0702 |
| s.dist | 0.432 |
| s.Sed | -0.42 |
| s.Ex | 0.0999 |
| p.Sed | 0.00204 |
| p.Ex | 0.464 |
| Gene | Sed | Ex |
|---|---|---|
| Rap1b | -3031 | 3218 |
| Fn1 | -3442 | 2688 |
| Ptpn1 | -3287 | 2808 |
| Ptk2 | -2270 | 3409 |
| Csk | -3349 | 1422 |
| Bcar1 | -3720 | 886 |
| Grb2 | -3855 | 698 |
| Vwf | -600 | 973 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3945 | -178 |
| Bcar1 | -3720 | 886 |
| Crk | -4206 | -3538 |
| Csk | -3349 | 1422 |
| Fn1 | -3442 | 2688 |
| Grb2 | -3855 | 698 |
| Pdpk1 | -427 | -2405 |
| Ptk2 | -2270 | 3409 |
| Ptpn1 | -3287 | 2808 |
| Rap1a | -4203 | -2974 |
| Rap1b | -3031 | 3218 |
| Rapgef3 | 1486 | -132 |
| Rasgrp2 | 964 | 1546 |
| Shc1 | 638 | 3990 |
| Sos1 | -369 | -3654 |
| Thpo | -1447 | -1828 |
| Tln1 | 829 | 2398 |
| Vwf | -600 | 973 |
REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.00345 |
| p.adjustMANOVA | 0.0507 |
| s.dist | 0.428 |
| s.Sed | -0.251 |
| s.Ex | 0.347 |
| p.Sed | 0.0524 |
| p.Ex | 0.00733 |
| Gene | Sed | Ex |
|---|---|---|
| B3gat3 | -4300 | 3673 |
| Bgn | -4102 | 3444 |
| B4galt7 | -4120 | 2846 |
| Hspg2 | -2360 | 4328 |
| Ids | -3049 | 3196 |
| Dse | -1378 | 2981 |
| Sdc2 | -2835 | 777 |
| Csgalnact2 | -2455 | 406 |
| Idua | -491 | 1334 |
| Hexa | -2473 | 94 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agrn | 4040 | 4011 |
| B3gat3 | -4300 | 3673 |
| B4galt7 | -4120 | 2846 |
| Bgn | -4102 | 3444 |
| Chpf2 | 1760 | 4326 |
| Csgalnact2 | -2455 | 406 |
| Dcn | -4548 | -899 |
| Dse | -1378 | 2981 |
| Gpc1 | 3261 | 1323 |
| Gpc4 | 4492 | 1225 |
| Gxylt1 | -2152 | -888 |
| Hexa | -2473 | 94 |
| Hexb | 407 | 3056 |
| Hspg2 | -2360 | 4328 |
| Ids | -3049 | 3196 |
| Idua | -491 | 1334 |
| Sdc2 | -2835 | 777 |
| Sdc3 | 750 | 1200 |
| Sdc4 | -2116 | -2595 |
| Vcan | -870 | -919 |
REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.0197 |
| p.adjustMANOVA | 0.172 |
| s.dist | 0.425 |
| s.Sed | 0.333 |
| s.Ex | 0.264 |
| p.Sed | 0.0255 |
| p.Ex | 0.0767 |
| Gene | Sed | Ex |
|---|---|---|
| Slc15a2 | 3370 | 4261 |
| Slc3a2 | 4157 | 2590 |
| Slc7a6 | 2226 | 3753 |
| Slc7a2 | 1750 | 4587 |
| Slc38a4 | 4365 | 1729 |
| Slc36a1 | 4397 | 1486 |
| Slc7a8 | 2513 | 2584 |
| Slc38a2 | 1521 | 3718 |
| Slc6a6 | 3788 | 1403 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Slc15a2 | 3370 | 4261 |
| Slc15a4 | -1363 | -3712 |
| Slc16a10 | 2752 | -137 |
| Slc1a5 | -4533 | 2325 |
| Slc36a1 | 4397 | 1486 |
| Slc38a2 | 1521 | 3718 |
| Slc38a3 | 1651 | -4292 |
| Slc38a4 | 4365 | 1729 |
| Slc3a2 | 4157 | 2590 |
| Slc43a1 | -2845 | 1590 |
| Slc43a2 | -592 | -2842 |
| Slc6a6 | 3788 | 1403 |
| Slc7a2 | 1750 | 4587 |
| Slc7a6 | 2226 | 3753 |
| Slc7a8 | 2513 | 2584 |
REACTOME_SIGNAL_AMPLIFICATION
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0318 |
| p.adjustMANOVA | 0.233 |
| s.dist | 0.41 |
| s.Sed | -0.157 |
| s.Ex | -0.379 |
| p.Sed | 0.311 |
| p.Ex | 0.014 |
| Gene | Sed | Ex |
|---|---|---|
| Gnaq | -4218 | -2690 |
| P2ry1 | -2459 | -4415 |
| Gng12 | -2199 | -3786 |
| Gnb4 | -2177 | -2146 |
| Gng11 | -930 | -464 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gna11 | -3535 | 1556 |
| Gna13 | -1752 | 36 |
| Gnai2 | 3716 | -1248 |
| Gnai3 | -3657 | 3506 |
| Gnaq | -4218 | -2690 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Mapk14 | 3679 | -270 |
| P2ry1 | -2459 | -4415 |
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0479 |
| p.adjustMANOVA | 0.307 |
| s.dist | 0.41 |
| s.Sed | -0.409 |
| s.Ex | 0.0272 |
| p.Sed | 0.0142 |
| p.Ex | 0.871 |
| Gene | Sed | Ex |
|---|---|---|
| Rps27a | -2114 | 4003 |
| Mknk1 | -3258 | 2550 |
| Braf | -1049 | 3595 |
| Grb2 | -3855 | 698 |
| Ppp2cb | -2623 | 898 |
| Mapk3 | -594 | 2518 |
| Cbl | -3959 | 27 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Braf | -1049 | 3595 |
| Cbl | -3959 | 27 |
| Grb2 | -3855 | 698 |
| Mapk1 | -2794 | -2107 |
| Mapk3 | -594 | 2518 |
| Mknk1 | -3258 | 2550 |
| Ppp2ca | -3907 | -4244 |
| Ppp2cb | -2623 | 898 |
| Ppp2r1a | 2128 | -957 |
| Rps27a | -2114 | 4003 |
| Spry2 | -1232 | -1637 |
| Uba52 | 1034 | -3115 |
REACTOME_AQUAPORIN_MEDIATED_TRANSPORT
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.00597 |
| p.adjustMANOVA | 0.0702 |
| s.dist | 0.409 |
| s.Sed | 0.133 |
| s.Ex | -0.387 |
| p.Sed | 0.305 |
| p.Ex | 0.00276 |
| Gene | Sed | Ex |
|---|---|---|
| Aqp1 | 3812 | -4137 |
| Adcy2 | 3180 | -2995 |
| Gnb1 | 2464 | -3575 |
| Adcy4 | 3736 | -1864 |
| Gnas | 3523 | -1457 |
| Prkar2a | 2972 | -977 |
| Gng5 | 670 | -4225 |
| Gnb2 | 449 | -2545 |
| Gnb5 | 193 | -3169 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adcy2 | 3180 | -2995 |
| Adcy4 | 3736 | -1864 |
| Adcy6 | -3979 | -817 |
| Adcy9 | 3412 | 251 |
| Aqp1 | 3812 | -4137 |
| Aqp4 | -1955 | -4480 |
| Gnas | 3523 | -1457 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Prkaca | -2139 | 1766 |
| Prkacb | 1802 | 153 |
| Prkar1a | 2086 | 461 |
| Prkar2a | 2972 | -977 |
| Rab11a | -1907 | -2603 |
| Rab11fip2 | -501 | 2466 |
REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.00597 |
| p.adjustMANOVA | 0.0702 |
| s.dist | 0.409 |
| s.Sed | 0.133 |
| s.Ex | -0.387 |
| p.Sed | 0.305 |
| p.Ex | 0.00276 |
| Gene | Sed | Ex |
|---|---|---|
| Aqp1 | 3812 | -4137 |
| Adcy2 | 3180 | -2995 |
| Gnb1 | 2464 | -3575 |
| Adcy4 | 3736 | -1864 |
| Gnas | 3523 | -1457 |
| Prkar2a | 2972 | -977 |
| Gng5 | 670 | -4225 |
| Gnb2 | 449 | -2545 |
| Gnb5 | 193 | -3169 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adcy2 | 3180 | -2995 |
| Adcy4 | 3736 | -1864 |
| Adcy6 | -3979 | -817 |
| Adcy9 | 3412 | 251 |
| Aqp1 | 3812 | -4137 |
| Aqp4 | -1955 | -4480 |
| Gnas | 3523 | -1457 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Prkaca | -2139 | 1766 |
| Prkacb | 1802 | 153 |
| Prkar1a | 2086 | 461 |
| Prkar2a | 2972 | -977 |
| Rab11a | -1907 | -2603 |
| Rab11fip2 | -501 | 2466 |
REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0893 |
| p.adjustMANOVA | 0.458 |
| s.dist | 0.405 |
| s.Sed | -0.387 |
| s.Ex | -0.122 |
| p.Sed | 0.0343 |
| p.Ex | 0.503 |
| Gene | Sed | Ex |
|---|---|---|
| Ablim1 | -4535 | -3645 |
| Fyn | -4226 | -2911 |
| Rac1 | -3001 | -3760 |
| Nck1 | -2681 | -867 |
| Wasl | -434 | -1588 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Ablim1 | -4535 | -3645 |
| Ablim3 | 1621 | -3192 |
| Cdc42 | -2856 | 2803 |
| Fyn | -4226 | -2911 |
| Nck1 | -2681 | -867 |
| Ntn1 | -3565 | 2946 |
| Ptk2 | -2270 | 3409 |
| Rac1 | -3001 | -3760 |
| Trio | 4450 | 1818 |
| Wasl | -434 | -1588 |
REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0313 |
| p.adjustMANOVA | 0.233 |
| s.dist | 0.405 |
| s.Sed | -0.0389 |
| s.Ex | 0.403 |
| p.Sed | 0.801 |
| p.Ex | 0.00907 |
| Gene | Sed | Ex |
|---|---|---|
| Fmod | -4542 | 4558 |
| Ogn | -4468 | 4111 |
| Prelp | -3668 | 3626 |
| Lum | -4098 | 128 |
| Hexa | -2473 | 94 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| B4galt1 | 1103 | 1807 |
| B4galt3 | 3134 | -1686 |
| B4galt5 | 3131 | 3001 |
| Fmod | -4542 | 4558 |
| Gns | 2799 | 3297 |
| Hexa | -2473 | 94 |
| Hexb | 407 | 3056 |
| Lum | -4098 | 128 |
| Ogn | -4468 | 4111 |
| Prelp | -3668 | 3626 |
| St3gal1 | 1685 | 4291 |
| St3gal2 | 3821 | -680 |
| St3gal3 | 3117 | 1589 |
| St3gal6 | -2166 | -522 |
REACTOME_METABOLISM_OF_PORPHYRINS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0613 |
| p.adjustMANOVA | 0.372 |
| s.dist | 0.404 |
| s.Sed | 0.278 |
| s.Ex | -0.293 |
| p.Sed | 0.11 |
| p.Ex | 0.0921 |
| Gene | Sed | Ex |
|---|---|---|
| Alad | 4350 | -3739 |
| Urod | 2893 | -2665 |
| Alas1 | 4569 | -1548 |
| Blvra | 2246 | -2820 |
| Hmox2 | 780 | -3690 |
| Cpox | 1001 | -1892 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Alad | 4350 | -3739 |
| Alas1 | 4569 | -1548 |
| Blvra | 2246 | -2820 |
| Cpox | 1001 | -1892 |
| Fech | -31 | 1856 |
| Hmbs | -608 | -232 |
| Hmox1 | 2519 | 2861 |
| Hmox2 | 780 | -3690 |
| Ppox | -1099 | -886 |
| Urod | 2893 | -2665 |
| Uros | -2403 | -1341 |
REACTOME_HS_GAG_DEGRADATION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0963 |
| p.adjustMANOVA | 0.472 |
| s.dist | 0.396 |
| s.Sed | 0.0267 |
| s.Ex | 0.395 |
| p.Sed | 0.884 |
| p.Ex | 0.0306 |
| Gene | Sed | Ex |
|---|---|---|
| Agrn | 4040 | 4011 |
| Gpc4 | 4492 | 1225 |
| Gpc1 | 3261 | 1323 |
| Sdc3 | 750 | 1200 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agrn | 4040 | 4011 |
| Gpc1 | 3261 | 1323 |
| Gpc4 | 4492 | 1225 |
| Gusb | -276 | 3897 |
| Hspg2 | -2360 | 4328 |
| Ids | -3049 | 3196 |
| Idua | -491 | 1334 |
| Sdc2 | -2835 | 777 |
| Sdc3 | 750 | 1200 |
| Sdc4 | -2116 | -2595 |
REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0226 |
| p.adjustMANOVA | 0.183 |
| s.dist | 0.395 |
| s.Sed | -0.39 |
| s.Ex | 0.0666 |
| p.Sed | 0.007 |
| p.Ex | 0.645 |
| Gene | Sed | Ex |
|---|---|---|
| Col1a1 | -3831 | 4630 |
| Rhob | -4386 | 3665 |
| Col1a2 | -3332 | 4583 |
| Cdc42 | -2856 | 2803 |
| Rhog | -303 | 4333 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3945 | -178 |
| Akt2 | 842 | 353 |
| Akt3 | -3476 | -830 |
| Cdc42 | -2856 | 2803 |
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Fyn | -4226 | -2911 |
| Pdpk1 | -427 | -2405 |
| Pik3ca | 1715 | -927 |
| Pik3cb | -1750 | -2810 |
| Pik3r1 | -3843 | -932 |
| Pik3r2 | 606 | 2034 |
| Pik3r3 | 4015 | -1793 |
| Rac1 | -3001 | -3760 |
| Rhob | -4386 | 3665 |
| Rhog | -303 | 4333 |
REACTOME_KERATAN_SULFATE_BIOSYNTHESIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0757 |
| p.adjustMANOVA | 0.422 |
| s.dist | 0.393 |
| s.Sed | -0.0629 |
| s.Ex | 0.388 |
| p.Sed | 0.718 |
| p.Ex | 0.0258 |
| Gene | Sed | Ex |
|---|---|---|
| Fmod | -4542 | 4558 |
| Ogn | -4468 | 4111 |
| Prelp | -3668 | 3626 |
| Lum | -4098 | 128 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| B4galt1 | 1103 | 1807 |
| B4galt3 | 3134 | -1686 |
| B4galt5 | 3131 | 3001 |
| Fmod | -4542 | 4558 |
| Lum | -4098 | 128 |
| Ogn | -4468 | 4111 |
| Prelp | -3668 | 3626 |
| St3gal1 | 1685 | 4291 |
| St3gal2 | 3821 | -680 |
| St3gal3 | 3117 | 1589 |
| St3gal6 | -2166 | -522 |
REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.033 |
| p.adjustMANOVA | 0.238 |
| s.dist | 0.384 |
| s.Sed | 0.183 |
| s.Ex | -0.337 |
| p.Sed | 0.219 |
| p.Ex | 0.0238 |
| Gene | Sed | Ex |
|---|---|---|
| Adcy2 | 3180 | -2995 |
| Gnb1 | 2464 | -3575 |
| Adcy4 | 3736 | -1864 |
| Gnas | 3523 | -1457 |
| Prkar2a | 2972 | -977 |
| Gng5 | 670 | -4225 |
| Gnb2 | 449 | -2545 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adcy2 | 3180 | -2995 |
| Adcy4 | 3736 | -1864 |
| Adcy6 | -3979 | -817 |
| Adcy9 | 3412 | 251 |
| Gnas | 3523 | -1457 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Prkaca | -2139 | 1766 |
| Prkacb | 1802 | 153 |
| Prkar1a | 2086 | 461 |
| Prkar2a | 2972 | -977 |
REACTOME_G_PROTEIN_ACTIVATION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.114 |
| p.adjustMANOVA | 0.498 |
| s.dist | 0.38 |
| s.Sed | 0.0087 |
| s.Ex | -0.38 |
| p.Sed | 0.962 |
| p.Ex | 0.0374 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb1 | 2464 | -3575 |
| Gnai2 | 3716 | -1248 |
| Gng5 | 670 | -4225 |
| Gnb2 | 449 | -2545 |
| Gnb5 | 193 | -3169 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Gnai2 | 3716 | -1248 |
| Gnai3 | -3657 | 3506 |
| Gnao1 | 2064 | 867 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0551 |
| p.adjustMANOVA | 0.348 |
| s.dist | 0.379 |
| s.Sed | -0.254 |
| s.Ex | 0.281 |
| p.Sed | 0.113 |
| p.Ex | 0.0793 |
| Gene | Sed | Ex |
|---|---|---|
| B3gat3 | -4300 | 3673 |
| Bgn | -4102 | 3444 |
| B4galt7 | -4120 | 2846 |
| Hspg2 | -2360 | 4328 |
| Sdc2 | -2835 | 777 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agrn | 4040 | 4011 |
| B3gat3 | -4300 | 3673 |
| B4galt7 | -4120 | 2846 |
| Bgn | -4102 | 3444 |
| Dcn | -4548 | -899 |
| Gpc1 | 3261 | 1323 |
| Gpc4 | 4492 | 1225 |
| Gxylt1 | -2152 | -888 |
| Hspg2 | -2360 | 4328 |
| Sdc2 | -2835 | 777 |
| Sdc3 | 750 | 1200 |
| Sdc4 | -2116 | -2595 |
| Vcan | -870 | -919 |
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0358 |
| p.adjustMANOVA | 0.243 |
| s.dist | 0.372 |
| s.Sed | -0.371 |
| s.Ex | 0.0272 |
| p.Sed | 0.0103 |
| p.Ex | 0.85 |
| Gene | Sed | Ex |
|---|---|---|
| Rps27a | -2114 | 4003 |
| Mknk1 | -3258 | 2550 |
| Braf | -1049 | 3595 |
| Frs2 | -4340 | 685 |
| Grb2 | -3855 | 698 |
| Ppp2cb | -2623 | 898 |
| Mapk3 | -594 | 2518 |
| Cbl | -3959 | 27 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Braf | -1049 | 3595 |
| Cbl | -3959 | 27 |
| Fgf1 | -4304 | -4003 |
| Fgf2 | 2717 | -1 |
| Fgfr1 | 1336 | 4068 |
| Frs2 | -4340 | 685 |
| Grb2 | -3855 | 698 |
| Mapk1 | -2794 | -2107 |
| Mapk3 | -594 | 2518 |
| Mknk1 | -3258 | 2550 |
| Ppp2ca | -3907 | -4244 |
| Ppp2cb | -2623 | 898 |
| Ppp2r1a | 2128 | -957 |
| Rps27a | -2114 | 4003 |
| Spry2 | -1232 | -1637 |
| Uba52 | 1034 | -3115 |
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0676 |
| p.adjustMANOVA | 0.401 |
| s.dist | 0.364 |
| s.Sed | -0.203 |
| s.Ex | -0.302 |
| p.Sed | 0.188 |
| p.Ex | 0.0503 |
| Gene | Sed | Ex |
|---|---|---|
| Gnaq | -4218 | -2690 |
| Gng12 | -2199 | -3786 |
| Mapk1 | -2794 | -2107 |
| Gnb4 | -2177 | -2146 |
| Gng11 | -930 | -464 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Arrb1 | -1062 | 3485 |
| Gna11 | -3535 | 1556 |
| Gna12 | 2743 | -1387 |
| Gna13 | -1752 | 36 |
| Gnaq | -4218 | -2690 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Mapk1 | -2794 | -2107 |
| Mapk3 | -594 | 2518 |
REACTOME_DOUBLE_STRAND_BREAK_REPAIR
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.107 |
| p.adjustMANOVA | 0.484 |
| s.dist | 0.358 |
| s.Sed | 0.301 |
| s.Ex | 0.194 |
| p.Sed | 0.0708 |
| p.Ex | 0.245 |
| Gene | Sed | Ex |
|---|---|---|
| Xrcc5 | 4361 | 4119 |
| Rpa1 | 4446 | 2068 |
| Prkdc | 2856 | 2970 |
| Xrcc6 | 3012 | 1679 |
| Lig4 | 1162 | 4267 |
| Nbn | 3118 | 558 |
| Atm | 2562 | 429 |
| Rpa2 | 248 | 226 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Atm | 2562 | 429 |
| Lig4 | 1162 | 4267 |
| Nbn | 3118 | 558 |
| Prkdc | 2856 | 2970 |
| Rad50 | -4460 | 3073 |
| Rad52 | -2984 | -3535 |
| Rpa1 | 4446 | 2068 |
| Rpa2 | 248 | 226 |
| Trp53bp1 | 4529 | -1808 |
| Xrcc4 | -2071 | -2651 |
| Xrcc5 | 4361 | 4119 |
| Xrcc6 | 3012 | 1679 |
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS
| metric | value |
|---|---|
| setSize | 40 |
| pMANOVA | 0.000407 |
| p.adjustMANOVA | 0.00865 |
| s.dist | 0.355 |
| s.Sed | -0.28 |
| s.Ex | 0.218 |
| p.Sed | 0.0022 |
| p.Ex | 0.0169 |
| Gene | Sed | Ex |
|---|---|---|
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Lamb1 | -3081 | 3776 |
| Itga9 | -2589 | 4070 |
| Rap1b | -3031 | 3218 |
| Col4a1 | -2257 | 4124 |
| Fn1 | -3442 | 2688 |
| Ptpn1 | -3287 | 2808 |
| Itga5 | -2133 | 3768 |
| Ptk2 | -2270 | 3409 |
| Itgb1 | -4396 | 1579 |
| Csk | -3349 | 1422 |
| Bcar1 | -3720 | 886 |
| Thbs1 | -751 | 4271 |
| Grb2 | -3855 | 698 |
| Vwf | -600 | 973 |
| Lama2 | -123 | 3844 |
| Itgb5 | -950 | 139 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Akt1 | -3945 | -178 |
| Bcar1 | -3720 | 886 |
| Bsg | 1383 | -3945 |
| Col1a1 | -3831 | 4630 |
| Col1a2 | -3332 | 4583 |
| Col4a1 | -2257 | 4124 |
| Col4a2 | 1752 | 2207 |
| Crk | -4206 | -3538 |
| Csk | -3349 | 1422 |
| Fbn1 | -4322 | -2128 |
| Fn1 | -3442 | 2688 |
| Grb2 | -3855 | 698 |
| Itga1 | 3753 | 578 |
| Itga5 | -2133 | 3768 |
| Itga9 | -2589 | 4070 |
| Itgav | -2349 | -1885 |
| Itgb1 | -4396 | 1579 |
| Itgb5 | -950 | 139 |
| Itgb6 | -3632 | -3098 |
| Jam2 | -4233 | -834 |
| Jam3 | -766 | -1704 |
| Lama2 | -123 | 3844 |
| Lama5 | 3918 | 4511 |
| Lamb1 | -3081 | 3776 |
| Lamb2 | 3957 | 4337 |
| Lamc1 | 1056 | 1874 |
| Pdpk1 | -427 | -2405 |
| Pecam1 | 1217 | -3046 |
| Ptk2 | -2270 | 3409 |
| Ptpn1 | -3287 | 2808 |
| Rap1a | -4203 | -2974 |
| Rap1b | -3031 | 3218 |
| Rapgef3 | 1486 | -132 |
| Rasgrp2 | 964 | 1546 |
| Shc1 | 638 | 3990 |
| Sos1 | -369 | -3654 |
| Thbs1 | -751 | 4271 |
| Tln1 | 829 | 2398 |
| Vtn | 4174 | -477 |
| Vwf | -600 | 973 |
REACTOME_METABOLISM_OF_POLYAMINES
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.122 |
| p.adjustMANOVA | 0.51 |
| s.dist | 0.354 |
| s.Sed | 0.343 |
| s.Ex | -0.0866 |
| p.Sed | 0.0488 |
| p.Ex | 0.619 |
| Gene | Sed | Ex |
|---|---|---|
| Odc1 | 3619 | -2499 |
| Got1 | 1234 | -4485 |
| Apip | 3893 | -454 |
| Mtap | 114 | -3061 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adi1 | 4052 | 303 |
| Amd1 | 2966 | 4165 |
| Apip | 3893 | -454 |
| Enoph1 | -2277 | -168 |
| Got1 | 1234 | -4485 |
| Mri1 | 4071 | 2740 |
| Mtap | 114 | -3061 |
| Odc1 | 3619 | -2499 |
| Sat1 | -747 | -748 |
| Smox | 3186 | 1098 |
| Sms | -2617 | -575 |
REACTOME_GLUCOSE_METABOLISM
| metric | value |
|---|---|
| setSize | 43 |
| pMANOVA | 0.000331 |
| p.adjustMANOVA | 0.00753 |
| s.dist | 0.352 |
| s.Sed | 0.35 |
| s.Ex | -0.0338 |
| p.Sed | 7.21e-05 |
| p.Ex | 0.702 |
| Gene | Sed | Ex |
|---|---|---|
| Got2 | 4306 | -4413 |
| Slc25a12 | 4526 | -4191 |
| Mdh2 | 4505 | -4175 |
| Gyg | 4017 | -2789 |
| Pgam2 | 3146 | -2898 |
| Mdh1 | 1408 | -4486 |
| Got1 | 1234 | -4485 |
| Pfkp | 2066 | -1564 |
| Pgk1 | 4540 | -620 |
| Fbp2 | 1144 | -1977 |
| Ppp2r1a | 2128 | -957 |
| Gbe1 | 7 | -4185 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Agl | 4326 | 4283 |
| Calm1 | 4582 | 3685 |
| Eno1 | 1645 | 4252 |
| Eno3 | 4566 | 1120 |
| Fbp2 | 1144 | -1977 |
| Gbe1 | 7 | -4185 |
| Got1 | 1234 | -4485 |
| Got2 | 4306 | -4413 |
| Gpi1 | 4570 | 3787 |
| Gyg | 4017 | -2789 |
| Gys1 | -2890 | -3029 |
| Mdh1 | 1408 | -4486 |
| Mdh2 | 4505 | -4175 |
| Pcx | 3841 | 883 |
| Pfkfb1 | 3251 | 162 |
| Pfkfb2 | -1533 | -3036 |
| Pfkfb3 | 3061 | 4619 |
| Pfkfb4 | -1467 | 986 |
| Pfkl | -2576 | 3705 |
| Pfkm | 4578 | 1694 |
| Pfkp | 2066 | -1564 |
| Pgam1 | 1492 | 161 |
| Pgam2 | 3146 | -2898 |
| Pgk1 | 4540 | -620 |
| Pgm1 | 4482 | 3569 |
| Phka1 | 4580 | 4576 |
| Phka2 | -3801 | -1125 |
| Phkb | 4318 | 3445 |
| Phkg1 | 4066 | 4440 |
| Phkg2 | 3154 | 2022 |
| Ppp2ca | -3907 | -4244 |
| Ppp2cb | -2623 | 898 |
| Ppp2r1a | 2128 | -957 |
| Ppp2r1b | -4158 | -2415 |
| Ppp2r5d | -182 | 2324 |
| Prkaca | -2139 | 1766 |
| Prkacb | 1802 | 153 |
| Pygb | -3233 | -2394 |
| Pygm | 4593 | 4507 |
| Slc25a11 | -789 | -4262 |
| Slc25a12 | 4526 | -4191 |
| Tpi1 | 3450 | 553 |
| Ugp2 | -572 | -4322 |
REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.126 |
| p.adjustMANOVA | 0.517 |
| s.dist | 0.351 |
| s.Sed | 0.341 |
| s.Ex | -0.0844 |
| p.Sed | 0.0502 |
| p.Ex | 0.628 |
| Gene | Sed | Ex |
|---|---|---|
| Impdh1 | 4147 | -2203 |
| Adsl | 1823 | -3605 |
| Adss | 3227 | -163 |
| Atic | 182 | -2098 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Adsl | 1823 | -3605 |
| Adss | 3227 | -163 |
| Adssl1 | 3902 | 142 |
| Atic | 182 | -2098 |
| Gart | -1474 | 3277 |
| Gmps | -4190 | -3845 |
| Impdh1 | 4147 | -2203 |
| Impdh2 | 2352 | 822 |
| Paics | 4241 | 74 |
| Pfas | -956 | 2535 |
| Ppat | 4133 | 1493 |
REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.154 |
| p.adjustMANOVA | 0.555 |
| s.dist | 0.351 |
| s.Sed | 0.0742 |
| s.Ex | -0.343 |
| p.Sed | 0.685 |
| p.Ex | 0.0608 |
| Gene | Sed | Ex |
|---|---|---|
| Gnb1 | 2464 | -3575 |
| Dlg1 | 3326 | -922 |
| Gng5 | 670 | -4225 |
| Gnb2 | 449 | -2545 |
| Gnb5 | 193 | -3169 |
Click HERE to show all gene set members
| Sed | Ex | |
|---|---|---|
| Calm1 | 4582 | 3685 |
| Dlg1 | 3326 | -922 |
| Gnb1 | 2464 | -3575 |
| Gnb2 | 449 | -2545 |
| Gnb4 | -2177 | -2146 |
| Gnb5 | 193 | -3169 |
| Gng11 | -930 | -464 |
| Gng12 | -2199 | -3786 |
| Gng5 | 670 | -4225 |
| Plcb3 | -2788 | 2082 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] plyr_1.8.7 pkgload_1.3.0
## [3] GGally_2.1.2 gtools_3.9.2.2
## [5] echarts4r_0.4.4 beeswarm_0.4.0
## [7] vioplot_0.3.7 sm_2.2-5.7
## [9] kableExtra_1.3.4 topconfects_1.12.0
## [11] limma_3.52.1 eulerr_6.1.1
## [13] mitch_1.8.0 MASS_7.3-58
## [15] fgsea_1.22.0 gplots_3.1.3
## [17] DESeq2_1.36.0 SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0 MatrixGenerics_1.8.0
## [21] matrixStats_0.62.0 GenomicRanges_1.48.0
## [23] GenomeInfoDb_1.32.2 IRanges_2.30.0
## [25] S4Vectors_0.34.0 BiocGenerics_0.42.0
## [27] reshape2_1.4.4 forcats_0.5.1
## [29] stringr_1.4.0 dplyr_1.0.9
## [31] purrr_0.3.4 readr_2.1.2
## [33] tidyr_1.2.0 tibble_3.1.7
## [35] ggplot2_3.3.6 tidyverse_1.3.1
## [37] zoo_1.8-10
##
## loaded via a namespace (and not attached):
## [1] readxl_1.4.0 backports_1.4.1 fastmatch_1.1-3
## [4] systemfonts_1.0.4 splines_4.2.1 BiocParallel_1.30.3
## [7] digest_0.6.29 htmltools_0.5.2 fansi_1.0.3
## [10] magrittr_2.0.3 memoise_2.0.1 tzdb_0.3.0
## [13] Biostrings_2.64.0 annotate_1.74.0 modelr_0.1.8
## [16] svglite_2.1.0 prettyunits_1.1.1 colorspace_2.0-3
## [19] blob_1.2.3 rvest_1.0.2 haven_2.5.0
## [22] xfun_0.31 crayon_1.5.1 RCurl_1.98-1.7
## [25] jsonlite_1.8.0 genefilter_1.78.0 survival_3.4-0
## [28] glue_1.6.2 gtable_0.3.0 zlibbioc_1.42.0
## [31] XVector_0.36.0 webshot_0.5.3 DelayedArray_0.22.0
## [34] scales_1.2.0 DBI_1.1.3 Rcpp_1.0.8.3
## [37] viridisLite_0.4.0 xtable_1.8-4 progress_1.2.2
## [40] bit_4.0.4 htmlwidgets_1.5.4 httr_1.4.3
## [43] RColorBrewer_1.1-3 ellipsis_0.3.2 pkgconfig_2.0.3
## [46] reshape_0.8.9 XML_3.99-0.10 farver_2.1.0
## [49] sass_0.4.1 dbplyr_2.2.1 locfit_1.5-9.5
## [52] utf8_1.2.2 tidyselect_1.1.2 labeling_0.4.2
## [55] rlang_1.0.3 later_1.3.0 AnnotationDbi_1.58.0
## [58] munsell_0.5.0 cellranger_1.1.0 tools_4.2.1
## [61] cachem_1.0.6 cli_3.3.0 generics_0.1.2
## [64] RSQLite_2.2.14 broom_0.8.0 evaluate_0.15
## [67] fastmap_1.1.0 yaml_2.3.5 knitr_1.39
## [70] bit64_4.0.5 fs_1.5.2 caTools_1.18.2
## [73] KEGGREST_1.36.2 mime_0.12 xml2_1.3.3
## [76] compiler_4.2.1 rstudioapi_0.13 png_0.1-7
## [79] reprex_2.0.1 geneplotter_1.74.0 bslib_0.3.1
## [82] stringi_1.7.6 highr_0.9 lattice_0.20-45
## [85] Matrix_1.4-1 vctrs_0.4.1 pillar_1.7.0
## [88] lifecycle_1.0.1 jquerylib_0.1.4 data.table_1.14.2
## [91] bitops_1.0-7 httpuv_1.6.5 R6_2.5.1
## [94] promises_1.2.0.1 KernSmooth_2.23-20 gridExtra_2.3
## [97] codetools_0.2-18 assertthat_0.2.1 withr_2.5.0
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1 hms_1.1.1
## [103] grid_4.2.1 rmarkdown_2.14 shiny_1.7.1
## [106] lubridate_1.8.0END of report