Mitch Report

date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                      ctrl      AcyKD
## 0610009B22Rik -0.08990061  0.3047981
## 0610009L18Rik -0.33354482 -0.2679990
## 0610010K14Rik -1.90686802 -0.7218075
## 0610012G03Rik  0.01318114 -0.1786497
## 0610030E20Rik -0.84194359 -0.4541127
## 0610040J01Rik  0.62289268 -1.3376144

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	9264
duplicated_genes_present	0
num_profile_genes_in_sets	2767
num_profile_genes_not_in_sets	6497
profile_pearson_correl	0.17837
profile_spearman_correl	0.15138

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	674
num_genesets_excluded	206
num_genesets_included	468

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 99

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.ctrl	s.AcyKD	p.ctrl	p.AcyKD
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	1.64e-06	3.07e-05	0.845	0.8240	0.1890	2.67e-07	2.38e-01
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	9.61e-09	3.75e-07	0.828	0.7990	0.2170	1.62e-09	1.02e-01
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	6.06e-06	7.49e-05	0.826	0.8170	0.1240	9.49e-07	4.58e-01
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	10	1.84e-04	1.51e-03	0.780	0.7510	0.2100	3.92e-05	2.50e-01
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	1.62e-04	1.35e-03	0.762	0.7000	0.3010	5.78e-05	8.36e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	3.56e-24	8.34e-22	0.711	0.7030	0.1050	2.70e-25	1.20e-01
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	1.04e-33	4.85e-31	0.704	0.6870	0.1550	1.02e-34	5.82e-03
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	4.16e-12	2.43e-10	0.704	0.6660	0.2290	1.19e-12	1.49e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	2.07e-19	3.22e-17	0.702	0.6970	0.0780	1.88e-20	3.01e-01
REACTOME PYRUVATE METABOLISM	16	2.04e-04	1.65e-03	0.622	0.5770	0.2310	6.38e-05	1.10e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	1.92e-03	1.18e-02	0.617	0.0540	0.6150	7.57e-01	4.15e-04
REACTOME COMPLEMENT CASCADE	11	9.72e-04	6.41e-03	0.600	-0.4950	0.3400	4.51e-03	5.10e-02
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	10	9.70e-03	4.61e-02	0.595	-0.4720	-0.3620	9.72e-03	4.76e-02
REACTOME PEPTIDE CHAIN ELONGATION	67	1.65e-14	1.55e-12	0.530	-0.4960	0.1890	2.42e-12	7.48e-03
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	5.54e-04	3.93e-03	0.511	0.3240	0.3950	8.58e-03	1.34e-03
REACTOME SIGNALING BY NOTCH4	11	2.41e-02	9.09e-02	0.508	-0.3020	-0.4090	8.29e-02	1.89e-02
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	13	1.29e-02	5.91e-02	0.501	-0.2540	-0.4320	1.13e-01	6.99e-03
REACTOME SIGNALING BY NOTCH2	11	2.81e-02	1.02e-01	0.499	-0.3400	-0.3660	5.11e-02	3.55e-02
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	4.56e-07	1.19e-05	0.496	0.4780	0.1320	8.25e-08	1.39e-01
REACTOME NCAM1 INTERACTIONS	15	1.61e-03	1.00e-02	0.494	-0.3120	0.3820	3.64e-02	1.04e-02
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	40	1.27e-06	2.58e-05	0.486	0.0989	0.4760	2.80e-01	1.96e-07
REACTOME SIGNALING BY HIPPO	15	3.31e-03	1.91e-02	0.486	-0.4780	0.0857	1.35e-03	5.66e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	2.99e-03	1.75e-02	0.481	0.4790	-0.0400	9.09e-04	7.82e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	42	9.97e-07	2.33e-05	0.477	0.0857	0.4690	3.37e-01	1.48e-07
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	40	2.28e-06	3.56e-05	0.473	0.0843	0.4660	3.57e-01	3.49e-07
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	8.49e-03	4.18e-02	0.472	-0.4560	0.1200	4.40e-03	4.54e-01
REACTOME SIGNALING BY NOTCH3	11	4.26e-02	1.34e-01	0.464	-0.2310	-0.4020	1.85e-01	2.09e-02
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	42	2.23e-06	3.56e-05	0.462	0.0789	0.4550	3.77e-01	3.38e-07
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	89	1.15e-14	1.34e-12	0.461	-0.4220	0.1850	6.08e-12	2.59e-03
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	42	2.40e-06	3.63e-05	0.461	0.0780	0.4540	3.82e-01	3.65e-07
REACTOME SIGNALING BY ROBO RECEPTOR	20	3.94e-03	2.17e-02	0.460	-0.3630	-0.2840	5.03e-03	2.82e-02
REACTOME GLUCONEOGENESIS	18	7.19e-03	3.59e-02	0.459	0.3260	0.3230	1.66e-02	1.77e-02
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	42	2.93e-07	8.56e-06	0.452	-0.3540	0.2810	7.45e-05	1.65e-03
REACTOME RAP1 SIGNALLING	12	4.01e-02	1.30e-01	0.450	-0.3780	-0.2450	2.34e-02	1.42e-01
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	16	7.20e-03	3.59e-02	0.450	-0.0117	-0.4500	9.36e-01	1.83e-03
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	20	5.01e-03	2.64e-02	0.448	-0.3720	-0.2510	4.03e-03	5.22e-02
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	45	1.83e-06	3.26e-05	0.448	0.0649	0.4430	4.52e-01	2.75e-07
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	42	6.93e-06	8.32e-05	0.446	0.1080	0.4330	2.27e-01	1.23e-06
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	43	5.00e-06	6.87e-05	0.444	0.0893	0.4350	3.12e-01	8.06e-07
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	83	1.54e-12	1.03e-10	0.440	-0.4020	0.1780	2.64e-10	5.16e-03
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	10	7.95e-02	2.18e-01	0.439	-0.3620	-0.2480	4.77e-02	1.75e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	14	1.83e-02	7.72e-02	0.435	0.0210	0.4340	8.92e-01	4.90e-03
REACTOME ER PHAGOSOME PATHWAY	48	1.15e-06	2.45e-05	0.434	0.0162	0.4340	8.46e-01	2.04e-07
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	10	5.81e-02	1.74e-01	0.420	0.0718	-0.4140	6.94e-01	2.34e-02
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	16	2.64e-02	9.65e-02	0.418	-0.3000	-0.2910	3.79e-02	4.39e-02
REACTOME PEROXISOMAL LIPID METABOLISM	16	2.54e-02	9.44e-02	0.417	0.3480	0.2300	1.60e-02	1.11e-01
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	48	5.41e-06	7.03e-05	0.412	0.0347	0.4100	6.78e-01	8.93e-07
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	43	3.02e-05	3.22e-04	0.410	0.0819	0.4020	3.53e-01	5.22e-06
REACTOME ORC1 REMOVAL FROM CHROMATIN	49	6.08e-06	7.49e-05	0.408	0.0513	0.4050	5.35e-01	9.60e-07
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	20	1.40e-02	6.23e-02	0.404	-0.3150	-0.2540	1.48e-02	4.96e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.ctrl	s.AcyKD	p.ctrl	p.AcyKD
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	1.64e-06	3.07e-05	0.8450	0.824000	0.18900	2.67e-07	2.38e-01
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	9.61e-09	3.75e-07	0.8280	0.799000	0.21700	1.62e-09	1.02e-01
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	6.06e-06	7.49e-05	0.8260	0.817000	0.12400	9.49e-07	4.58e-01
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	10	1.84e-04	1.51e-03	0.7800	0.751000	0.21000	3.92e-05	2.50e-01
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	1.62e-04	1.35e-03	0.7620	0.700000	0.30100	5.78e-05	8.36e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	3.56e-24	8.34e-22	0.7110	0.703000	0.10500	2.70e-25	1.20e-01
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	1.04e-33	4.85e-31	0.7040	0.687000	0.15500	1.02e-34	5.82e-03
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	4.16e-12	2.43e-10	0.7040	0.666000	0.22900	1.19e-12	1.49e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	2.07e-19	3.22e-17	0.7020	0.697000	0.07800	1.88e-20	3.01e-01
REACTOME PYRUVATE METABOLISM	16	2.04e-04	1.65e-03	0.6220	0.577000	0.23100	6.38e-05	1.10e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	1.92e-03	1.18e-02	0.6170	0.054000	0.61500	7.57e-01	4.15e-04
REACTOME COMPLEMENT CASCADE	11	9.72e-04	6.41e-03	0.6000	-0.495000	0.34000	4.51e-03	5.10e-02
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	10	9.70e-03	4.61e-02	0.5950	-0.472000	-0.36200	9.72e-03	4.76e-02
REACTOME PEPTIDE CHAIN ELONGATION	67	1.65e-14	1.55e-12	0.5300	-0.496000	0.18900	2.42e-12	7.48e-03
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	5.54e-04	3.93e-03	0.5110	0.324000	0.39500	8.58e-03	1.34e-03
REACTOME SIGNALING BY NOTCH4	11	2.41e-02	9.09e-02	0.5080	-0.302000	-0.40900	8.29e-02	1.89e-02
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	13	1.29e-02	5.91e-02	0.5010	-0.254000	-0.43200	1.13e-01	6.99e-03
REACTOME SIGNALING BY NOTCH2	11	2.81e-02	1.02e-01	0.4990	-0.340000	-0.36600	5.11e-02	3.55e-02
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	4.56e-07	1.19e-05	0.4960	0.478000	0.13200	8.25e-08	1.39e-01
REACTOME NCAM1 INTERACTIONS	15	1.61e-03	1.00e-02	0.4940	-0.312000	0.38200	3.64e-02	1.04e-02
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	40	1.27e-06	2.58e-05	0.4860	0.098900	0.47600	2.80e-01	1.96e-07
REACTOME SIGNALING BY HIPPO	15	3.31e-03	1.91e-02	0.4860	-0.478000	0.08570	1.35e-03	5.66e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	2.99e-03	1.75e-02	0.4810	0.479000	-0.04000	9.09e-04	7.82e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	42	9.97e-07	2.33e-05	0.4770	0.085700	0.46900	3.37e-01	1.48e-07
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	40	2.28e-06	3.56e-05	0.4730	0.084300	0.46600	3.57e-01	3.49e-07
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	8.49e-03	4.18e-02	0.4720	-0.456000	0.12000	4.40e-03	4.54e-01
REACTOME SIGNALING BY NOTCH3	11	4.26e-02	1.34e-01	0.4640	-0.231000	-0.40200	1.85e-01	2.09e-02
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	42	2.23e-06	3.56e-05	0.4620	0.078900	0.45500	3.77e-01	3.38e-07
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	89	1.15e-14	1.34e-12	0.4610	-0.422000	0.18500	6.08e-12	2.59e-03
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	42	2.40e-06	3.63e-05	0.4610	0.078000	0.45400	3.82e-01	3.65e-07
REACTOME SIGNALING BY ROBO RECEPTOR	20	3.94e-03	2.17e-02	0.4600	-0.363000	-0.28400	5.03e-03	2.82e-02
REACTOME GLUCONEOGENESIS	18	7.19e-03	3.59e-02	0.4590	0.326000	0.32300	1.66e-02	1.77e-02
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	42	2.93e-07	8.56e-06	0.4520	-0.354000	0.28100	7.45e-05	1.65e-03
REACTOME RAP1 SIGNALLING	12	4.01e-02	1.30e-01	0.4500	-0.378000	-0.24500	2.34e-02	1.42e-01
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	16	7.20e-03	3.59e-02	0.4500	-0.011700	-0.45000	9.36e-01	1.83e-03
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	20	5.01e-03	2.64e-02	0.4480	-0.372000	-0.25100	4.03e-03	5.22e-02
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	45	1.83e-06	3.26e-05	0.4480	0.064900	0.44300	4.52e-01	2.75e-07
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	42	6.93e-06	8.32e-05	0.4460	0.108000	0.43300	2.27e-01	1.23e-06
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	43	5.00e-06	6.87e-05	0.4440	0.089300	0.43500	3.12e-01	8.06e-07
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	83	1.54e-12	1.03e-10	0.4400	-0.402000	0.17800	2.64e-10	5.16e-03
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	10	7.95e-02	2.18e-01	0.4390	-0.362000	-0.24800	4.77e-02	1.75e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	14	1.83e-02	7.72e-02	0.4350	0.021000	0.43400	8.92e-01	4.90e-03
REACTOME ER PHAGOSOME PATHWAY	48	1.15e-06	2.45e-05	0.4340	0.016200	0.43400	8.46e-01	2.04e-07
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	10	5.81e-02	1.74e-01	0.4200	0.071800	-0.41400	6.94e-01	2.34e-02
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	16	2.64e-02	9.65e-02	0.4180	-0.300000	-0.29100	3.79e-02	4.39e-02
REACTOME PEROXISOMAL LIPID METABOLISM	16	2.54e-02	9.44e-02	0.4170	0.348000	0.23000	1.60e-02	1.11e-01
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	48	5.41e-06	7.03e-05	0.4120	0.034700	0.41000	6.78e-01	8.93e-07
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	43	3.02e-05	3.22e-04	0.4100	0.081900	0.40200	3.53e-01	5.22e-06
REACTOME ORC1 REMOVAL FROM CHROMATIN	49	6.08e-06	7.49e-05	0.4080	0.051300	0.40500	5.35e-01	9.60e-07
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	20	1.40e-02	6.23e-02	0.4040	-0.315000	-0.25400	1.48e-02	4.96e-02
REACTOME GLUCOSE METABOLISM	43	9.89e-05	8.90e-04	0.4040	0.231000	0.33200	8.75e-03	1.71e-04
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	56	1.45e-06	2.83e-05	0.3990	0.018100	0.39900	8.15e-01	2.52e-07
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	53	4.30e-06	6.10e-05	0.3990	0.052300	0.39500	5.11e-01	6.68e-07
REACTOME SOS MEDIATED SIGNALLING	13	5.56e-02	1.68e-01	0.3970	-0.382000	-0.11000	1.73e-02	4.92e-01
REACTOME CALNEXIN CALRETICULIN CYCLE	11	6.37e-02	1.89e-01	0.3950	-0.391000	0.05880	2.48e-02	7.36e-01
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	85	2.00e-10	8.51e-09	0.3950	-0.366000	0.14900	6.06e-09	1.78e-02
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	46	3.56e-05	3.62e-04	0.3920	0.071000	0.38600	4.06e-01	6.08e-06
REACTOME POTASSIUM CHANNELS	22	3.50e-03	1.99e-02	0.3920	0.126000	-0.37100	3.06e-01	2.60e-03
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	11	8.09e-02	2.19e-01	0.3920	-0.036400	-0.39000	8.34e-01	2.52e-02
REACTOME SEMAPHORIN INTERACTIONS	41	2.84e-04	2.18e-03	0.3910	-0.296000	-0.25600	1.06e-03	4.57e-03
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	49	1.95e-06	3.26e-05	0.3910	-0.262000	0.29000	1.56e-03	4.51e-04
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	56	3.88e-06	5.68e-05	0.3890	0.045900	0.38600	5.53e-01	6.06e-07
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	86	1.60e-10	7.50e-09	0.3880	-0.317000	0.22400	3.91e-07	3.49e-04
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	18	2.63e-02	9.65e-02	0.3870	-0.171000	-0.34700	2.08e-01	1.08e-02
REACTOME REGULATION OF MITOTIC CELL CYCLE	60	1.90e-06	3.26e-05	0.3870	0.049800	0.38400	5.06e-01	2.87e-07
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	56	5.14e-06	6.87e-05	0.3830	0.039600	0.38100	6.09e-01	8.23e-07
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	14	6.62e-02	1.92e-01	0.3830	-0.210000	-0.32100	1.73e-01	3.79e-02
REACTOME FRS2 MEDIATED CASCADE	17	4.09e-02	1.30e-01	0.3800	-0.260000	-0.27700	6.35e-02	4.79e-02
REACTOME GPCR LIGAND BINDING	39	1.48e-04	1.26e-03	0.3750	0.063300	-0.37000	4.94e-01	6.54e-05
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	20	2.34e-02	9.06e-02	0.3750	-0.178000	-0.32900	1.68e-01	1.08e-02
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	45	9.42e-05	8.76e-04	0.3730	0.039500	0.37100	6.47e-01	1.70e-05
REACTOME TRNA AMINOACYLATION	39	8.44e-04	5.64e-03	0.3730	0.223000	0.29800	1.61e-02	1.28e-03
REACTOME M G1 TRANSITION	51	2.65e-05	2.95e-04	0.3720	0.026600	0.37100	7.43e-01	4.73e-06
REACTOME SIGNAL ATTENUATION	10	1.70e-01	3.58e-01	0.3680	-0.218000	-0.29600	2.33e-01	1.05e-01
REACTOME REGULATION OF APOPTOSIS	48	7.52e-05	7.18e-04	0.3650	0.034900	0.36300	6.76e-01	1.35e-05
REACTOME PLATELET AGGREGATION PLUG FORMATION	17	5.34e-02	1.63e-01	0.3640	-0.232000	-0.28000	9.80e-02	4.58e-02
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	13	9.47e-02	2.46e-01	0.3630	-0.339000	-0.12800	3.42e-02	4.26e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS	16	6.80e-02	1.94e-01	0.3590	-0.269000	-0.23900	6.31e-02	9.87e-02
REACTOME TRANSLATION	124	7.65e-13	5.97e-11	0.3590	-0.262000	0.24500	5.11e-07	2.64e-06
REACTOME GLUTATHIONE CONJUGATION	12	8.53e-02	2.27e-01	0.3570	0.352000	-0.06060	3.50e-02	7.16e-01
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	53	5.18e-05	5.16e-04	0.3560	0.044700	0.35300	5.74e-01	8.94e-06
REACTOME DESTABILIZATION OF MRNA BY KSRP	14	7.43e-02	2.08e-01	0.3550	-0.352000	-0.04850	2.26e-02	7.53e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	17	5.36e-02	1.63e-01	0.3550	-0.136000	-0.32800	3.32e-01	1.94e-02
REACTOME TRAFFICKING OF AMPA RECEPTORS	16	3.43e-02	1.17e-01	0.3520	-0.324000	0.13900	2.51e-02	3.38e-01
REACTOME INFLUENZA LIFE CYCLE	114	3.22e-11	1.68e-09	0.3510	-0.303000	0.17700	2.51e-08	1.13e-03
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	31	1.25e-03	8.04e-03	0.3500	-0.270000	0.22300	9.46e-03	3.15e-02
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	13	1.21e-01	2.88e-01	0.3480	-0.165000	-0.30700	3.04e-01	5.55e-02
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	105	7.59e-08	2.54e-06	0.3480	0.234000	0.25700	3.48e-05	5.78e-06
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	14	9.61e-02	2.47e-01	0.3460	-0.329000	-0.10500	3.29e-02	4.95e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	21	3.20e-02	1.12e-01	0.3440	-0.324000	-0.11700	1.03e-02	3.54e-01
REACTOME CELL CELL JUNCTION ORGANIZATION	15	1.01e-01	2.55e-01	0.3410	-0.283000	-0.19000	5.81e-02	2.03e-01
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	50	2.26e-04	1.80e-03	0.3400	0.057700	0.33500	4.81e-01	4.20e-05
REACTOME HS GAG BIOSYNTHESIS	15	9.76e-02	2.50e-01	0.3400	-0.155000	-0.30200	2.98e-01	4.28e-02
REACTOME STRIATED MUSCLE CONTRACTION	22	3.36e-02	1.17e-01	0.3390	0.299000	0.16000	1.51e-02	1.94e-01
REACTOME TELOMERE MAINTENANCE	19	2.87e-02	1.02e-01	0.3380	-0.328000	0.07920	1.33e-02	5.50e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	11	1.18e-01	2.86e-01	0.3370	-0.145000	0.30400	4.04e-01	8.12e-02
REACTOME SIGNAL AMPLIFICATION	15	9.50e-02	2.46e-01	0.3350	-0.104000	-0.31900	4.88e-01	3.26e-02
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	24	1.31e-02	5.91e-02	0.3340	0.063400	-0.32800	5.91e-01	5.42e-03
REACTOME SYNTHESIS OF DNA	61	2.76e-05	3.01e-04	0.3340	-0.011000	0.33400	8.83e-01	6.66e-06
REACTOME DOUBLE STRAND BREAK REPAIR	12	1.57e-01	3.46e-01	0.3330	0.106000	0.31600	5.25e-01	5.84e-02
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	21	1.94e-02	7.96e-02	0.3330	0.129000	-0.30700	3.07e-01	1.51e-02
REACTOME BASE EXCISION REPAIR	13	9.03e-02	2.37e-01	0.3290	-0.133000	0.30200	4.07e-01	5.99e-02
REACTOME NETRIN1 SIGNALING	21	5.19e-02	1.60e-01	0.3290	-0.254000	-0.20900	4.41e-02	9.81e-02
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	20	4.16e-02	1.31e-01	0.3290	-0.042200	-0.32600	7.44e-01	1.17e-02
REACTOME SIGNALING BY WNT	56	1.39e-04	1.22e-03	0.3280	0.037900	0.32600	6.24e-01	2.53e-05
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	11	1.72e-01	3.59e-01	0.3280	-0.028500	-0.32600	8.70e-01	6.10e-02
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	13	1.02e-01	2.57e-01	0.3270	-0.074100	0.31900	6.44e-01	4.65e-02
REACTOME DESTABILIZATION OF MRNA BY BRF1	16	9.13e-02	2.39e-01	0.3260	-0.313000	-0.09410	3.05e-02	5.15e-01
REACTOME INWARDLY RECTIFYING K CHANNELS	11	1.38e-01	3.15e-01	0.3240	0.134000	-0.29500	4.40e-01	9.01e-02
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	20	6.46e-02	1.89e-01	0.3230	-0.187000	-0.26300	1.48e-01	4.17e-02
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	27	2.01e-02	8.16e-02	0.3210	-0.094000	-0.30700	3.98e-01	5.73e-03
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	11	2.29e-01	4.38e-01	0.3210	-0.222000	-0.23100	2.02e-01	1.84e-01
REACTOME LAGGING STRAND SYNTHESIS	10	1.98e-01	3.96e-01	0.3200	-0.319000	0.02840	8.06e-02	8.76e-01
REACTOME SIGNALLING TO ERKS	28	2.39e-02	9.09e-02	0.3200	-0.200000	-0.25000	6.76e-02	2.23e-02
REACTOME MTORC1 MEDIATED SIGNALLING	11	2.23e-01	4.31e-01	0.3200	0.154000	0.28000	3.77e-01	1.08e-01
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	16	1.11e-01	2.73e-01	0.3180	-0.292000	-0.12600	4.36e-02	3.83e-01
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	10	1.93e-01	3.88e-01	0.3170	0.071000	-0.30900	6.98e-01	9.04e-02
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	12	1.70e-01	3.58e-01	0.3170	-0.045600	-0.31400	7.84e-01	5.97e-02
REACTOME GLYCOLYSIS	19	7.96e-02	2.18e-01	0.3150	0.149000	0.27800	2.62e-01	3.60e-02
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	40	5.57e-03	2.86e-02	0.3140	-0.177000	-0.26000	5.29e-02	4.53e-03
REACTOME FATTY ACYL COA BIOSYNTHESIS	12	1.27e-01	2.95e-01	0.3140	-0.266000	0.16700	1.11e-01	3.15e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	1.23e-01	2.90e-01	0.3130	-0.313000	-0.00270	4.26e-02	9.86e-01
REACTOME ADP SIGNALLING THROUGH P2RY12	10	2.49e-01	4.59e-01	0.3110	-0.067000	-0.30400	7.14e-01	9.63e-02
REACTOME G ALPHA I SIGNALLING EVENTS	29	1.89e-02	7.83e-02	0.3100	-0.076000	-0.30100	4.79e-01	5.07e-03
REACTOME MYOGENESIS	21	7.08e-02	2.00e-01	0.3100	-0.255000	-0.17600	4.36e-02	1.62e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	11	2.47e-01	4.57e-01	0.3070	-0.275000	-0.13600	1.14e-01	4.34e-01
REACTOME INTERFERON GAMMA SIGNALING	24	1.89e-02	7.83e-02	0.3070	-0.189000	0.24200	1.10e-01	4.01e-02
REACTOME SPRY REGULATION OF FGF SIGNALING	12	2.29e-01	4.38e-01	0.3050	-0.168000	-0.25400	3.13e-01	1.27e-01
REACTOME COLLAGEN FORMATION	26	1.54e-02	6.78e-02	0.3030	-0.174000	0.24800	1.26e-01	2.85e-02
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	11	1.72e-01	3.59e-01	0.3020	0.182000	-0.24100	2.97e-01	1.66e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	23	6.45e-02	1.89e-01	0.3010	-0.175000	-0.24500	1.46e-01	4.19e-02
REACTOME PURINE SALVAGE	10	2.86e-01	4.85e-01	0.2990	-0.286000	-0.08720	1.18e-01	6.33e-01
REACTOME SHC MEDIATED CASCADE	11	2.73e-01	4.78e-01	0.2960	-0.133000	-0.26500	4.45e-01	1.29e-01
REACTOME CELL CYCLE CHECKPOINTS	77	3.32e-05	3.45e-04	0.2950	-0.008510	0.29500	8.98e-01	7.90e-06
REACTOME ADP SIGNALLING THROUGH P2RY1	12	2.00e-01	3.98e-01	0.2890	0.045700	-0.28500	7.84e-01	8.73e-02
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	11	2.86e-01	4.85e-01	0.2890	-0.114000	-0.26500	5.15e-01	1.28e-01
REACTOME VIRAL MESSENGER RNA SYNTHESIS	14	1.40e-01	3.16e-01	0.2880	-0.108000	0.26700	4.84e-01	8.37e-02
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	18	1.31e-01	3.03e-01	0.2880	-0.264000	-0.11400	5.26e-02	4.04e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	11	3.05e-01	5.02e-01	0.2870	-0.226000	-0.17700	1.94e-01	3.08e-01
REACTOME ARMS MEDIATED ACTIVATION	14	2.23e-01	4.31e-01	0.2870	-0.222000	-0.18100	1.50e-01	2.42e-01
REACTOME EXTENSION OF TELOMERES	15	1.49e-01	3.35e-01	0.2860	-0.286000	0.01200	5.54e-02	9.36e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	15	1.68e-01	3.57e-01	0.2840	0.034700	0.28200	8.16e-01	5.89e-02
REACTOME AXON GUIDANCE	141	5.21e-07	1.28e-05	0.2800	-0.239000	-0.14500	1.03e-06	3.07e-03
REACTOME G1 S TRANSITION	67	3.55e-04	2.59e-03	0.2790	0.003950	0.27900	9.56e-01	7.87e-05
REACTOME SHC MEDIATED SIGNALLING	13	2.46e-01	4.57e-01	0.2790	-0.263000	-0.09210	1.01e-01	5.66e-01
REACTOME PLATELET SENSITIZATION BY LDL	11	3.29e-01	5.26e-01	0.2790	-0.196000	-0.19800	2.59e-01	2.57e-01
REACTOME REGULATION OF KIT SIGNALING	10	3.60e-01	5.50e-01	0.2780	-0.230000	-0.15700	2.08e-01	3.91e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	10	3.68e-01	5.54e-01	0.2760	-0.221000	-0.16500	2.26e-01	3.65e-01
REACTOME S PHASE	71	2.36e-04	1.84e-03	0.2740	-0.025700	0.27300	7.08e-01	7.29e-05
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	18	1.36e-01	3.11e-01	0.2730	-0.272000	-0.02480	4.62e-02	8.56e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION	60	1.09e-03	7.10e-03	0.2690	-0.025500	0.26800	7.34e-01	3.39e-04
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	16	1.66e-01	3.57e-01	0.2680	0.013000	-0.26800	9.28e-01	6.34e-02
REACTOME G PROTEIN ACTIVATION	11	2.97e-01	4.95e-01	0.2670	0.007100	-0.26700	9.67e-01	1.25e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	39	2.38e-02	9.09e-02	0.2670	-0.114000	-0.24100	2.17e-01	9.35e-03
REACTOME SIGNALLING TO RAS	20	1.58e-01	3.46e-01	0.2660	-0.197000	-0.17900	1.27e-01	1.66e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE	17	1.20e-01	2.88e-01	0.2660	-0.168000	0.20600	2.30e-01	1.42e-01
REACTOME IL RECEPTOR SHC SIGNALING	15	2.42e-01	4.53e-01	0.2630	0.101000	0.24300	4.98e-01	1.04e-01
REACTOME DNA STRAND ELONGATION	14	1.99e-01	3.96e-01	0.2630	-0.250000	0.08200	1.06e-01	5.95e-01
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	19	1.17e-01	2.86e-01	0.2620	-0.068900	0.25300	6.03e-01	5.69e-02
REACTOME HOST INTERACTIONS OF HIV FACTORS	97	6.25e-05	6.10e-04	0.2620	0.035300	0.25900	5.49e-01	1.08e-05
REACTOME G0 AND EARLY G1	11	3.65e-01	5.53e-01	0.2610	-0.123000	-0.23100	4.82e-01	1.85e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	51	1.13e-02	5.30e-02	0.2600	-0.185000	-0.18300	2.24e-02	2.38e-02
REACTOME MICRORNA MIRNA BIOGENESIS	18	1.22e-01	2.89e-01	0.2580	-0.182000	0.18200	1.82e-01	1.81e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	16	1.55e-01	3.44e-01	0.2580	0.156000	-0.20500	2.81e-01	1.56e-01
REACTOME REGULATION OF INSULIN SECRETION	39	3.39e-02	1.17e-01	0.2560	-0.131000	-0.22000	1.59e-01	1.76e-02
REACTOME LIPOPROTEIN METABOLISM	11	3.13e-01	5.10e-01	0.2550	-0.249000	0.05260	1.52e-01	7.63e-01
REACTOME P75NTR SIGNALS VIA NFKB	10	3.65e-01	5.53e-01	0.2540	-0.253000	0.01730	1.66e-01	9.25e-01
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	12	2.66e-01	4.73e-01	0.2540	-0.111000	0.22800	5.05e-01	1.72e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	17	2.43e-01	4.53e-01	0.2530	-0.194000	-0.16200	1.67e-01	2.47e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	31	7.69e-02	2.14e-01	0.2520	-0.184000	-0.17300	7.65e-02	9.62e-02
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	44	9.75e-03	4.61e-02	0.2510	-0.237000	0.08200	6.55e-03	3.48e-01
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	10	4.30e-01	5.95e-01	0.2500	-0.226000	-0.10700	2.17e-01	5.60e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	11	3.22e-01	5.17e-01	0.2480	0.075800	-0.23700	6.64e-01	1.74e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	25	6.82e-02	1.94e-01	0.2480	-0.134000	0.20900	2.47e-01	7.06e-02
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	46	2.30e-02	9.06e-02	0.2480	-0.216000	-0.12200	1.12e-02	1.53e-01
REACTOME HIV INFECTION	156	1.13e-06	2.45e-05	0.2460	0.033800	0.24400	4.69e-01	1.66e-07
REACTOME BASIGIN INTERACTIONS	14	3.33e-01	5.28e-01	0.2460	0.180000	0.16700	2.43e-01	2.80e-01
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	38	3.66e-02	1.22e-01	0.2450	0.040800	0.24100	6.64e-01	1.01e-02
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	15	2.11e-01	4.13e-01	0.2430	-0.161000	0.18200	2.82e-01	2.23e-01
REACTOME SULFUR AMINO ACID METABOLISM	17	2.64e-01	4.73e-01	0.2420	0.211000	0.12000	1.33e-01	3.93e-01
REACTOME SHC RELATED EVENTS	14	3.45e-01	5.37e-01	0.2410	-0.187000	-0.15200	2.26e-01	3.24e-01
REACTOME REGULATORY RNA PATHWAYS	21	1.18e-01	2.86e-01	0.2400	-0.183000	0.15600	1.47e-01	2.16e-01
REACTOME ELONGATION ARREST AND RECOVERY	24	1.08e-01	2.69e-01	0.2390	-0.049400	0.23400	6.75e-01	4.77e-02
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	55	1.71e-02	7.39e-02	0.2380	-0.141000	-0.19200	7.16e-02	1.39e-02
REACTOME SMOOTH MUSCLE CONTRACTION	18	2.39e-01	4.52e-01	0.2360	-0.053100	-0.23000	6.97e-01	9.16e-02
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	31	8.25e-02	2.22e-01	0.2350	-0.038400	-0.23200	7.12e-01	2.55e-02
REACTOME P38MAPK EVENTS	10	4.44e-01	6.03e-01	0.2340	-0.028000	-0.23300	8.78e-01	2.03e-01
REACTOME SIGNALING BY NOTCH1	51	2.51e-02	9.39e-02	0.2340	-0.196000	-0.12900	1.57e-02	1.12e-01
REACTOME METABOLISM OF MRNA	178	5.18e-08	1.87e-06	0.2330	-0.175000	0.15400	5.97e-05	4.38e-04
REACTOME PHOSPHORYLATION OF THE APC C	14	2.97e-01	4.95e-01	0.2330	-0.033900	0.23000	8.26e-01	1.36e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING	13	2.89e-01	4.89e-01	0.2320	0.168000	-0.16000	2.94e-01	3.17e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	12	3.20e-01	5.16e-01	0.2320	0.163000	-0.16500	3.29e-01	3.22e-01
REACTOME PHASE II CONJUGATION	24	1.59e-01	3.46e-01	0.2320	0.226000	0.05150	5.57e-02	6.62e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	34	5.85e-02	1.74e-01	0.2300	-0.229000	0.02420	2.11e-02	8.07e-01
REACTOME REGULATION OF IFNG SIGNALING	10	4.24e-01	5.95e-01	0.2290	-0.049900	0.22400	7.85e-01	2.20e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	13	4.03e-01	5.83e-01	0.2280	-0.105000	-0.20300	5.14e-01	2.06e-01
REACTOME INSULIN RECEPTOR RECYCLING	15	3.36e-01	5.29e-01	0.2270	0.218000	0.06210	1.43e-01	6.77e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	13	3.86e-01	5.70e-01	0.2270	-0.055700	-0.22000	7.28e-01	1.70e-01
REACTOME DEADENYLATION OF MRNA	16	3.32e-01	5.28e-01	0.2260	0.101000	0.20200	4.87e-01	1.61e-01
REACTOME NEPHRIN INTERACTIONS	15	2.82e-01	4.82e-01	0.2260	0.062200	-0.21700	6.77e-01	1.46e-01
REACTOME G2 M CHECKPOINTS	16	2.40e-01	4.53e-01	0.2260	-0.130000	0.18500	3.69e-01	2.01e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS	11	4.72e-01	6.24e-01	0.2260	0.104000	0.20000	5.49e-01	2.51e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	10	5.14e-01	6.58e-01	0.2250	-0.134000	-0.18100	4.64e-01	3.21e-01
REACTOME DNA REPAIR	68	3.57e-03	1.99e-02	0.2250	-0.054800	0.21800	4.36e-01	1.88e-03
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	110	7.05e-04	4.78e-03	0.2250	-0.188000	-0.12300	6.74e-04	2.69e-02
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	18	2.97e-01	4.95e-01	0.2230	-0.093800	-0.20300	4.91e-01	1.37e-01
REACTOME SIGNALING BY RHO GTPASES	63	1.82e-02	7.72e-02	0.2220	-0.148000	-0.16500	4.26e-02	2.39e-02
REACTOME DEVELOPMENTAL BIOLOGY	237	3.98e-07	1.10e-05	0.2200	-0.175000	-0.13400	3.94e-06	4.28e-04
REACTOME METAL ION SLC TRANSPORTERS	12	4.12e-01	5.88e-01	0.2200	-0.001210	-0.22000	9.94e-01	1.88e-01
REACTOME ERKS ARE INACTIVATED	10	5.13e-01	6.58e-01	0.2180	-0.061600	-0.20900	7.36e-01	2.53e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	54	3.94e-02	1.29e-01	0.2150	-0.136000	-0.16600	8.50e-02	3.48e-02
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	50	3.85e-02	1.27e-01	0.2140	0.052600	0.20800	5.20e-01	1.11e-02
REACTOME NUCLEOTIDE EXCISION REPAIR	40	4.03e-02	1.30e-01	0.2140	-0.133000	0.16800	1.47e-01	6.67e-02
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	26	1.75e-01	3.63e-01	0.2140	-0.031200	-0.21200	7.83e-01	6.21e-02
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	15	4.12e-01	5.88e-01	0.2130	0.156000	0.14600	2.97e-01	3.28e-01
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	22	2.73e-01	4.78e-01	0.2110	-0.182000	-0.10700	1.41e-01	3.87e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	10	4.63e-01	6.19e-01	0.2100	-0.177000	0.11400	3.34e-01	5.33e-01
REACTOME GABA RECEPTOR ACTIVATION	16	3.11e-01	5.09e-01	0.2090	0.067500	-0.19800	6.40e-01	1.71e-01
REACTOME METABOLISM OF RNA	217	9.94e-08	3.10e-06	0.2070	-0.151000	0.14200	1.37e-04	3.46e-04
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	21	2.38e-01	4.52e-01	0.2070	-0.030900	0.20400	8.06e-01	1.05e-01
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	19	2.69e-01	4.73e-01	0.2060	-0.202000	0.04250	1.28e-01	7.49e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	17	3.45e-01	5.37e-01	0.2050	-0.204000	-0.01970	1.45e-01	8.88e-01
REACTOME BIOLOGICAL OXIDATIONS	39	8.46e-02	2.26e-01	0.2040	0.204000	0.00121	2.79e-02	9.90e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	72	6.50e-03	3.31e-02	0.2040	-0.077700	0.18800	2.55e-01	5.85e-03
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	81	8.65e-03	4.22e-02	0.2030	0.047300	0.19800	4.63e-01	2.14e-03
REACTOME MEIOSIS	24	1.79e-01	3.68e-01	0.2030	-0.110000	0.17000	3.49e-01	1.49e-01
REACTOME MITOTIC G1 G1 S PHASES	82	4.04e-03	2.20e-02	0.2020	-0.056000	0.19400	3.82e-01	2.42e-03
REACTOME RNA POL III TRANSCRIPTION	31	1.27e-01	2.95e-01	0.2010	-0.049400	0.19500	6.35e-01	6.01e-02
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	50	3.58e-02	1.21e-01	0.2010	-0.194000	0.05370	1.79e-02	5.12e-01
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	18	3.35e-01	5.29e-01	0.2010	0.201000	0.01370	1.41e-01	9.20e-01
REACTOME GLOBAL GENOMIC NER GG NER	25	1.75e-01	3.63e-01	0.1990	-0.123000	0.15600	2.86e-01	1.76e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	16	3.39e-01	5.31e-01	0.1990	-0.081900	0.18100	5.71e-01	2.09e-01
REACTOME PLATELET HOMEOSTASIS	33	1.20e-01	2.88e-01	0.1990	0.039800	-0.19500	6.92e-01	5.28e-02
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	15	4.07e-01	5.86e-01	0.1990	0.007950	0.19900	9.58e-01	1.83e-01
REACTOME MRNA CAPPING	28	2.07e-01	4.09e-01	0.1990	0.047800	0.19300	6.62e-01	7.73e-02
REACTOME MRNA SPLICING	100	2.46e-03	1.48e-02	0.1990	-0.000914	0.19900	9.87e-01	6.18e-04
REACTOME G ALPHA S SIGNALLING EVENTS	29	1.60e-01	3.46e-01	0.1980	0.033200	-0.19600	7.57e-01	6.85e-02
REACTOME SIGNALING BY NOTCH	75	2.16e-02	8.64e-02	0.1980	-0.157000	-0.12100	1.91e-02	6.99e-02
REACTOME GLYCOSPHINGOLIPID METABOLISM	21	2.80e-01	4.82e-01	0.1980	-0.198000	0.00861	1.17e-01	9.46e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	189	2.54e-05	2.90e-04	0.1980	0.032500	0.19500	4.44e-01	4.24e-06
REACTOME REGULATION OF SIGNALING BY CBL	14	4.30e-01	5.95e-01	0.1970	-0.197000	0.00595	2.01e-01	9.69e-01
REACTOME TRANSCRIPTION COUPLED NER TC NER	36	8.83e-02	2.34e-01	0.1960	-0.116000	0.15800	2.29e-01	1.01e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	42	6.80e-02	1.94e-01	0.1960	0.185000	-0.06430	3.84e-02	4.72e-01
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	28	1.86e-01	3.79e-01	0.1950	-0.018300	0.19400	8.67e-01	7.52e-02
REACTOME ERK MAPK TARGETS	18	3.93e-01	5.76e-01	0.1950	-0.077000	-0.17900	5.72e-01	1.88e-01
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	19	3.14e-01	5.11e-01	0.1950	-0.028900	0.19300	8.27e-01	1.46e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	24	2.61e-01	4.73e-01	0.1940	-0.020100	-0.19300	8.65e-01	1.02e-01
REACTOME INTERFERON ALPHA BETA SIGNALING	17	4.27e-01	5.95e-01	0.1930	-0.171000	-0.08900	2.22e-01	5.26e-01
REACTOME MRNA PROCESSING	139	6.21e-04	4.28e-03	0.1920	0.030900	0.19000	5.31e-01	1.22e-04
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	3.61e-01	5.50e-01	0.1920	0.062800	0.18100	6.27e-01	1.61e-01
REACTOME RECYCLING PATHWAY OF L1	19	3.03e-01	5.01e-01	0.1920	-0.173000	0.08250	1.92e-01	5.34e-01
REACTOME CELL CELL COMMUNICATION	53	8.06e-02	2.19e-01	0.1910	-0.122000	-0.14700	1.25e-01	6.39e-02
REACTOME RNA POL I TRANSCRIPTION	26	1.88e-01	3.82e-01	0.1910	-0.141000	0.12900	2.14e-01	2.56e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	15	3.91e-01	5.75e-01	0.1910	-0.085800	0.17100	5.65e-01	2.53e-01
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	17	4.27e-01	5.95e-01	0.1890	-0.180000	-0.05950	2.00e-01	6.71e-01
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	17	4.27e-01	5.95e-01	0.1890	-0.180000	-0.05950	2.00e-01	6.71e-01
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	10	6.04e-01	7.40e-01	0.1890	-0.182000	-0.04980	3.19e-01	7.85e-01
REACTOME GPCR DOWNSTREAM SIGNALING	106	5.32e-03	2.77e-02	0.1880	-0.049700	-0.18100	3.78e-01	1.32e-03
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	126	1.43e-03	9.07e-03	0.1870	0.009360	0.18600	8.57e-01	3.18e-04
REACTOME CTLA4 INHIBITORY SIGNALING	16	4.84e-01	6.35e-01	0.1870	-0.140000	-0.12300	3.32e-01	3.94e-01
REACTOME CELL JUNCTION ORGANIZATION	29	2.65e-01	4.73e-01	0.1860	-0.157000	-0.09940	1.43e-01	3.55e-01
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	56	4.46e-02	1.39e-01	0.1860	-0.033100	0.18300	6.69e-01	1.81e-02
REACTOME TIE2 SIGNALING	13	5.46e-01	6.94e-01	0.1860	0.167000	0.08190	2.98e-01	6.09e-01
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	15	4.15e-01	5.88e-01	0.1850	0.167000	-0.07920	2.62e-01	5.95e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	97	4.84e-03	2.58e-02	0.1840	0.042900	-0.17900	4.67e-01	2.40e-03
REACTOME INNATE IMMUNE SYSTEM	120	2.65e-03	1.57e-02	0.1830	-0.182000	-0.01700	5.84e-04	7.49e-01
REACTOME EGFR DOWNREGULATION	23	2.82e-01	4.82e-01	0.1830	-0.177000	0.04510	1.41e-01	7.08e-01
REACTOME HEMOSTASIS	217	9.55e-05	8.76e-04	0.1830	-0.120000	-0.13800	2.39e-03	5.18e-04
REACTOME G1 PHASE	25	2.94e-01	4.95e-01	0.1830	-0.181000	-0.02640	1.18e-01	8.20e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	43	9.92e-02	2.52e-01	0.1830	-0.032800	0.18000	7.10e-01	4.17e-02
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	21	3.47e-01	5.37e-01	0.1830	-0.008030	-0.18300	9.49e-01	1.48e-01
REACTOME SIGNALING BY NODAL	11	6.16e-01	7.49e-01	0.1830	-0.098800	-0.15400	5.71e-01	3.78e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	17	3.73e-01	5.57e-01	0.1810	-0.125000	0.13100	3.73e-01	3.48e-01
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	17	4.02e-01	5.83e-01	0.1810	-0.176000	0.04330	2.10e-01	7.57e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	164	6.11e-04	4.27e-03	0.1800	0.046700	0.17400	3.05e-01	1.33e-04
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	17	4.45e-01	6.03e-01	0.1780	-0.012200	-0.17800	9.31e-01	2.05e-01
REACTOME HIV LIFE CYCLE	94	9.63e-03	4.61e-02	0.1780	-0.017900	0.17700	7.65e-01	3.16e-03
REACTOME GABA B RECEPTOR ACTIVATION	15	4.67e-01	6.23e-01	0.1770	0.031900	-0.17400	8.31e-01	2.43e-01
REACTOME NOD1 2 SIGNALING PATHWAY	18	4.83e-01	6.35e-01	0.1760	-0.116000	-0.13300	3.96e-01	3.29e-01
REACTOME RNA POL III CHAIN ELONGATION	16	4.16e-01	5.88e-01	0.1760	-0.121000	0.12800	4.03e-01	3.74e-01
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	27	2.56e-01	4.69e-01	0.1750	-0.046500	0.16900	6.76e-01	1.29e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	14	4.77e-01	6.29e-01	0.1750	0.084700	-0.15300	5.83e-01	3.22e-01
REACTOME ACTIVATED TLR4 SIGNALLING	62	7.93e-02	2.18e-01	0.1740	-0.070300	-0.15900	3.39e-01	3.08e-02
REACTOME GLYCOSAMINOGLYCAN METABOLISM	46	1.60e-01	3.46e-01	0.1740	-0.092100	-0.14700	2.80e-01	8.45e-02
REACTOME SIGNALING BY FGFR1 MUTANTS	21	4.31e-01	5.95e-01	0.1720	-0.156000	-0.07180	2.16e-01	5.69e-01
REACTOME G ALPHA Q SIGNALLING EVENTS	43	1.10e-01	2.72e-01	0.1710	0.103000	-0.13700	2.43e-01	1.21e-01
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	38	1.52e-01	3.40e-01	0.1700	-0.075800	0.15200	4.19e-01	1.05e-01
REACTOME NEURONAL SYSTEM	89	2.86e-02	1.02e-01	0.1700	-0.053200	-0.16100	3.87e-01	8.67e-03
REACTOME RNA POL II TRANSCRIPTION	86	2.89e-02	1.02e-01	0.1690	0.030300	0.16600	6.29e-01	7.80e-03
REACTOME TRANSCRIPTION	127	4.31e-03	2.32e-02	0.1690	0.002480	0.16900	9.62e-01	1.08e-03
REACTOME SIGNALING BY GPCR	146	3.58e-03	1.99e-02	0.1680	-0.053000	-0.15900	2.72e-01	9.63e-04
REACTOME MITOTIC M M G1 PHASES	96	1.77e-02	7.59e-02	0.1670	0.005420	0.16700	9.27e-01	4.80e-03
REACTOME PPARA ACTIVATES GENE EXPRESSION	80	2.33e-02	9.06e-02	0.1670	0.063000	-0.15500	3.31e-01	1.70e-02
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	21	4.32e-01	5.95e-01	0.1660	-0.027000	-0.16300	8.31e-01	1.95e-01
REACTOME PERK REGULATED GENE EXPRESSION	21	4.12e-01	5.88e-01	0.1650	-0.165000	0.00867	1.92e-01	9.45e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	97	2.31e-02	9.06e-02	0.1650	0.031000	0.16200	5.98e-01	6.08e-03
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	15	5.01e-01	6.49e-01	0.1640	-0.146000	0.07460	3.29e-01	6.17e-01
REACTOME TCR SIGNALING	27	3.22e-01	5.17e-01	0.1640	-0.163000	0.01200	1.42e-01	9.14e-01
REACTOME ACTIVATION OF GENES BY ATF4	19	4.69e-01	6.23e-01	0.1640	-0.163000	-0.01490	2.19e-01	9.11e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	28	3.60e-01	5.50e-01	0.1630	0.061500	0.15100	5.73e-01	1.66e-01
REACTOME RNA POL I TRANSCRIPTION TERMINATION	19	4.15e-01	5.88e-01	0.1630	-0.083600	0.14000	5.28e-01	2.90e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	13	5.81e-01	7.23e-01	0.1630	0.016000	-0.16200	9.21e-01	3.12e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	65	1.04e-01	2.60e-01	0.1630	-0.086400	-0.13800	2.29e-01	5.50e-02
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	18	4.97e-01	6.46e-01	0.1620	-0.020900	-0.16100	8.78e-01	2.37e-01
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	37	2.63e-01	4.73e-01	0.1620	-0.152000	-0.05520	1.10e-01	5.62e-01
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	58	1.26e-01	2.95e-01	0.1610	-0.053600	-0.15200	4.81e-01	4.64e-02
REACTOME APOPTOSIS	96	2.09e-02	8.43e-02	0.1600	-0.016000	0.16000	7.87e-01	7.03e-03
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	35	2.60e-01	4.73e-01	0.1600	0.010300	0.16000	9.16e-01	1.02e-01
REACTOME DNA REPLICATION	108	1.31e-02	5.91e-02	0.1600	-0.016500	0.15900	7.68e-01	4.36e-03
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	11	6.36e-01	7.64e-01	0.1600	-0.158000	0.02660	3.65e-01	8.79e-01
REACTOME SYNTHESIS OF PA	10	6.58e-01	7.78e-01	0.1580	0.051100	-0.15000	7.80e-01	4.13e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	98	3.79e-02	1.26e-01	0.1580	-0.142000	-0.07010	1.56e-02	2.32e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	18	4.96e-01	6.46e-01	0.1580	-0.010800	0.15700	9.37e-01	2.48e-01
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	57	1.34e-01	3.09e-01	0.1580	-0.039100	-0.15300	6.11e-01	4.64e-02
REACTOME CELL CYCLE MITOTIC	189	4.69e-04	3.38e-03	0.1570	-0.053000	0.14800	2.12e-01	5.05e-04
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	13	6.06e-01	7.41e-01	0.1560	0.015000	-0.15600	9.25e-01	3.32e-01
REACTOME MRNA SPLICING MINOR PATHWAY	39	1.93e-01	3.88e-01	0.1560	-0.134000	0.07930	1.47e-01	3.92e-01
REACTOME RNA POL I TRANSCRIPTION INITIATION	23	3.76e-01	5.59e-01	0.1560	-0.087400	0.12900	4.69e-01	2.83e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	48	2.19e-01	4.27e-01	0.1560	0.091900	0.12600	2.72e-01	1.33e-01
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	17	5.80e-01	7.23e-01	0.1550	0.134000	0.07940	3.41e-01	5.71e-01
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	16	6.01e-01	7.38e-01	0.1550	-0.131000	-0.08400	3.66e-01	5.61e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	11	7.09e-01	8.16e-01	0.1550	0.113000	0.10600	5.16e-01	5.43e-01
REACTOME INTERFERON SIGNALING	80	3.63e-02	1.22e-01	0.1550	-0.081600	0.13200	2.08e-01	4.23e-02
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	24	4.40e-01	6.03e-01	0.1540	0.032800	0.15100	7.81e-01	2.01e-01
REACTOME LATE PHASE OF HIV LIFE CYCLE	86	4.52e-02	1.40e-01	0.1540	-0.002280	0.15400	9.71e-01	1.41e-02
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	42	2.43e-01	4.53e-01	0.1540	-0.033600	-0.15000	7.07e-01	9.34e-02
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	59	1.68e-01	3.57e-01	0.1520	-0.085100	-0.12600	2.59e-01	9.50e-02
REACTOME TRIF MEDIATED TLR3 SIGNALING	54	1.83e-01	3.75e-01	0.1520	-0.058500	-0.14000	4.58e-01	7.54e-02
REACTOME G ALPHA1213 SIGNALLING EVENTS	43	2.68e-01	4.73e-01	0.1520	-0.076500	-0.13100	3.86e-01	1.37e-01
REACTOME IL 3 5 AND GM CSF SIGNALING	25	3.67e-01	5.54e-01	0.1520	-0.128000	0.08180	2.69e-01	4.79e-01
REACTOME MUSCLE CONTRACTION	36	2.81e-01	4.82e-01	0.1520	0.152000	-0.00225	1.16e-01	9.81e-01
REACTOME CELL CYCLE	214	3.02e-04	2.28e-03	0.1510	-0.061700	0.13700	1.22e-01	5.81e-04
REACTOME ENOS ACTIVATION AND REGULATION	12	6.90e-01	8.01e-01	0.1500	-0.053300	-0.14000	7.49e-01	4.01e-01
REACTOME CTNNB1 PHOSPHORYLATION CASCADE	14	6.69e-01	7.82e-01	0.1490	-0.105000	-0.10500	4.95e-01	4.97e-01
REACTOME MITOTIC G2 G2 M PHASES	49	1.60e-01	3.46e-01	0.1480	-0.063700	0.13400	4.41e-01	1.06e-01
REACTOME DOWNSTREAM TCR SIGNALING	20	4.70e-01	6.23e-01	0.1470	-0.076200	0.12600	5.56e-01	3.29e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	25	4.88e-01	6.38e-01	0.1470	-0.126000	-0.07610	2.76e-01	5.11e-01
REACTOME TOLL RECEPTOR CASCADES	74	1.27e-01	2.95e-01	0.1460	-0.119000	-0.08500	7.72e-02	2.07e-01
REACTOME PKB MEDIATED EVENTS	27	4.46e-01	6.03e-01	0.1460	0.038700	0.14000	7.28e-01	2.07e-01
REACTOME DIABETES PATHWAYS	90	6.73e-02	1.94e-01	0.1450	-0.142000	-0.03350	2.06e-02	5.83e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	28	3.71e-01	5.55e-01	0.1450	0.051200	-0.13600	6.39e-01	2.14e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	23	4.40e-01	6.03e-01	0.1450	0.057100	-0.13300	6.36e-01	2.69e-01
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	175	2.36e-03	1.43e-02	0.1450	0.047700	-0.13700	2.79e-01	1.91e-03
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	22	4.59e-01	6.18e-01	0.1450	0.052600	-0.13500	6.70e-01	2.74e-01
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	52	2.24e-01	4.31e-01	0.1450	-0.050100	-0.13600	5.32e-01	9.10e-02
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	18	5.85e-01	7.27e-01	0.1440	-0.141000	-0.03270	3.02e-01	8.10e-01
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	29	4.51e-01	6.08e-01	0.1440	0.075800	0.12300	4.80e-01	2.54e-01
REACTOME SPHINGOLIPID METABOLISM	36	2.77e-01	4.80e-01	0.1430	-0.112000	0.08810	2.45e-01	3.61e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS	22	4.62e-01	6.19e-01	0.1420	-0.079700	0.11700	5.18e-01	3.42e-01
REACTOME MEMBRANE TRAFFICKING	93	4.10e-02	1.30e-01	0.1410	-0.123000	0.07000	4.11e-02	2.45e-01
REACTOME CHROMOSOME MAINTENANCE	36	3.08e-01	5.06e-01	0.1410	-0.136000	0.03630	1.57e-01	7.07e-01
REACTOME PIP3 ACTIVATES AKT SIGNALING	25	4.46e-01	6.03e-01	0.1400	0.033700	-0.13600	7.71e-01	2.39e-01
REACTOME L1CAM INTERACTIONS	51	2.68e-01	4.73e-01	0.1400	-0.078600	-0.11600	3.32e-01	1.52e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	10	7.12e-01	8.16e-01	0.1400	-0.119000	0.07280	5.14e-01	6.90e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS	14	6.86e-01	7.98e-01	0.1390	-0.045600	-0.13200	7.68e-01	3.94e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	12	7.31e-01	8.28e-01	0.1390	-0.057900	-0.12600	7.29e-01	4.50e-01
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	127	1.59e-02	6.96e-02	0.1390	0.124000	-0.06270	1.66e-02	2.24e-01
REACTOME IL 2 SIGNALING	25	4.31e-01	5.95e-01	0.1380	-0.106000	0.08860	3.58e-01	4.44e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	61	1.83e-01	3.75e-01	0.1340	0.010000	-0.13300	8.93e-01	7.23e-02
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	14	7.21e-01	8.23e-01	0.1340	0.108000	0.07940	4.86e-01	6.07e-01
REACTOME SIGNALLING BY NGF	155	2.86e-02	1.02e-01	0.1340	-0.085600	-0.10300	6.71e-02	2.83e-02
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	147	1.19e-02	5.50e-02	0.1330	-0.117000	0.06420	1.52e-02	1.81e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	17	6.12e-01	7.46e-01	0.1330	0.030000	-0.13000	8.30e-01	3.55e-01
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	19	5.90e-01	7.31e-01	0.1330	0.011400	-0.13200	9.31e-01	3.18e-01
REACTOME METABOLISM OF PROTEINS	301	1.41e-04	1.22e-03	0.1320	-0.078500	0.10600	2.04e-02	1.79e-03
REACTOME SIGNALING BY BMP	17	6.64e-01	7.82e-01	0.1310	-0.126000	-0.03740	3.71e-01	7.89e-01
REACTOME MEIOTIC SYNAPSIS	15	6.35e-01	7.64e-01	0.1310	-0.088100	0.09690	5.55e-01	5.16e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	22	5.48e-01	6.95e-01	0.1310	-0.018100	0.13000	8.84e-01	2.93e-01
REACTOME SIGNALING BY ILS	66	2.10e-01	4.12e-01	0.1290	-0.126000	-0.02870	7.79e-02	6.88e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS	10	7.71e-01	8.61e-01	0.1280	-0.127000	0.01650	4.88e-01	9.28e-01
REACTOME NUCLEAR SIGNALING BY ERBB4	22	6.20e-01	7.50e-01	0.1280	-0.112000	-0.06140	3.64e-01	6.18e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY	33	3.97e-01	5.81e-01	0.1280	-0.113000	0.05910	2.61e-01	5.57e-01
REACTOME PI 3K CASCADE	35	3.83e-01	5.67e-01	0.1280	0.046000	-0.11900	6.38e-01	2.24e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	19	6.58e-01	7.78e-01	0.1280	-0.053900	-0.11600	6.84e-01	3.83e-01
REACTOME SIGNAL TRANSDUCTION BY L1	28	5.53e-01	6.96e-01	0.1270	-0.080900	-0.09850	4.59e-01	3.67e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	51	3.16e-01	5.12e-01	0.1260	0.031200	0.12200	7.01e-01	1.31e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	12	7.52e-01	8.46e-01	0.1260	-0.126000	-0.01240	4.51e-01	9.41e-01
REACTOME ADAPTIVE IMMUNE SYSTEM	335	3.38e-04	2.51e-03	0.1240	-0.020900	0.12200	5.16e-01	1.44e-04
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	22	6.37e-01	7.64e-01	0.1220	0.045100	0.11400	7.14e-01	3.57e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	14	7.08e-01	8.16e-01	0.1200	-0.057600	0.10500	7.09e-01	4.98e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	22	6.67e-01	7.82e-01	0.1190	0.078800	0.08910	5.22e-01	4.70e-01
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	17	6.57e-01	7.78e-01	0.1190	-0.068400	0.09710	6.26e-01	4.89e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	71	2.75e-01	4.78e-01	0.1170	-0.057200	-0.10200	4.06e-01	1.37e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	33	5.51e-01	6.96e-01	0.1160	-0.102000	-0.05650	3.12e-01	5.75e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	31	5.73e-01	7.17e-01	0.1160	-0.102000	-0.05420	3.24e-01	6.02e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	62	2.69e-01	4.73e-01	0.1160	-0.115000	0.01490	1.19e-01	8.40e-01
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	52	4.07e-01	5.86e-01	0.1150	-0.087800	-0.07490	2.74e-01	3.51e-01
REACTOME IMMUNE SYSTEM	515	1.36e-05	1.59e-04	0.1150	-0.061700	0.09680	1.84e-02	2.15e-04
REACTOME UNFOLDED PROTEIN RESPONSE	63	3.49e-01	5.39e-01	0.1130	-0.095800	-0.05940	1.90e-01	4.16e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	17	7.35e-01	8.28e-01	0.1130	0.110000	0.02450	4.33e-01	8.61e-01
REACTOME MRNA 3 END PROCESSING	31	6.00e-01	7.38e-01	0.1120	0.061100	0.09370	5.56e-01	3.67e-01
REACTOME SIGNALING BY FGFR MUTANTS	28	6.38e-01	7.64e-01	0.1110	-0.086500	-0.06930	4.29e-01	5.26e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	10	8.10e-01	8.86e-01	0.1100	0.053800	-0.09650	7.68e-01	5.97e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	28	5.53e-01	6.96e-01	0.1100	0.067300	-0.08670	5.38e-01	4.28e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	21	7.11e-01	8.16e-01	0.1070	-0.103000	-0.03060	4.14e-01	8.08e-01
REACTOME METABOLISM OF CARBOHYDRATES	128	1.50e-01	3.36e-01	0.1070	0.059700	0.08840	2.45e-01	8.53e-02
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	13	8.06e-01	8.86e-01	0.1060	-0.011900	-0.10500	9.41e-01	5.12e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	23	7.17e-01	8.20e-01	0.1050	0.081100	0.06730	5.01e-01	5.77e-01
REACTOME SIGNALING BY PDGF	86	2.64e-01	4.73e-01	0.1050	-0.101000	-0.02770	1.05e-01	6.58e-01
REACTOME LYSOSOME VESICLE BIOGENESIS	17	7.28e-01	8.28e-01	0.1040	-0.051100	0.09050	7.15e-01	5.19e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	21	7.06e-01	8.16e-01	0.1040	-0.104000	0.00142	4.10e-01	9.91e-01
REACTOME GLUCOSE TRANSPORT	30	5.98e-01	7.38e-01	0.1020	0.099500	-0.02400	3.46e-01	8.20e-01
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	37	6.20e-01	7.50e-01	0.0995	-0.060200	-0.07920	5.27e-01	4.05e-01
REACTOME SIGNALING BY FGFR	70	4.02e-01	5.83e-01	0.0966	-0.028100	-0.09240	6.85e-01	1.82e-01
REACTOME SIGNALING BY FGFR IN DISEASE	83	3.69e-01	5.54e-01	0.0962	-0.058500	-0.07630	3.58e-01	2.31e-01
REACTOME OPIOID SIGNALLING	41	5.34e-01	6.81e-01	0.0950	0.037100	-0.08750	6.82e-01	3.33e-01
REACTOME METABOLISM OF NUCLEOTIDES	48	5.07e-01	6.56e-01	0.0920	-0.030600	0.08670	7.14e-01	2.99e-01
REACTOME RNA POL III TRANSCRIPTION TERMINATION	18	7.66e-01	8.57e-01	0.0918	-0.061000	0.06860	6.55e-01	6.15e-01
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	101	3.37e-01	5.29e-01	0.0913	-0.057900	-0.07060	3.17e-01	2.22e-01
REACTOME CIRCADIAN CLOCK	42	6.46e-01	7.69e-01	0.0896	-0.061900	-0.06470	4.88e-01	4.69e-01
REACTOME INTEGRATION OF ENERGY METABOLISM	62	5.21e-01	6.67e-01	0.0895	-0.074900	-0.04890	3.09e-01	5.06e-01
REACTOME METABOLISM OF POLYAMINES	12	8.81e-01	9.30e-01	0.0893	0.046400	0.07640	7.81e-01	6.47e-01
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	24	7.64e-01	8.57e-01	0.0878	0.014700	0.08660	9.01e-01	4.63e-01
REACTOME SIGNALING BY ERBB4	67	5.11e-01	6.58e-01	0.0875	-0.072800	-0.04860	3.04e-01	4.92e-01
REACTOME PYRIMIDINE METABOLISM	10	8.95e-01	9.40e-01	0.0856	0.085500	0.00439	6.40e-01	9.81e-01
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	22	8.07e-01	8.86e-01	0.0851	-0.037700	-0.07620	7.59e-01	5.36e-01
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	16	8.55e-01	9.17e-01	0.0843	-0.029000	-0.07920	8.41e-01	5.84e-01
REACTOME DARPP 32 EVENTS	18	8.39e-01	9.06e-01	0.0834	-0.023500	-0.08000	8.63e-01	5.57e-01
REACTOME PI3K CASCADE	46	6.69e-01	7.82e-01	0.0822	0.056900	0.05930	5.05e-01	4.87e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	61	5.67e-01	7.11e-01	0.0820	-0.026500	-0.07760	7.21e-01	2.95e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM	14	8.62e-01	9.19e-01	0.0796	-0.027000	0.07480	8.61e-01	6.28e-01
REACTOME G ALPHA Z SIGNALLING EVENTS	22	8.18e-01	8.90e-01	0.0784	-0.007110	-0.07810	9.54e-01	5.27e-01
REACTOME PI3K AKT ACTIVATION	31	7.29e-01	8.28e-01	0.0769	0.037800	-0.06690	7.16e-01	5.19e-01
REACTOME GENERIC TRANSCRIPTION PATHWAY	134	3.57e-01	5.49e-01	0.0765	-0.037900	-0.06640	4.51e-01	1.86e-01
REACTOME HS GAG DEGRADATION	10	9.16e-01	9.52e-01	0.0762	0.076200	0.00270	6.77e-01	9.88e-01
REACTOME METABOLISM OF PORPHYRINS	11	8.95e-01	9.40e-01	0.0757	0.047800	-0.05870	7.84e-01	7.36e-01
REACTOME IL1 SIGNALING	26	8.22e-01	8.93e-01	0.0739	-0.069300	-0.02560	5.41e-01	8.21e-01
REACTOME SIGNALING BY SCF KIT	57	6.70e-01	7.82e-01	0.0735	-0.046800	-0.05670	5.42e-01	4.60e-01
REACTOME PURINE METABOLISM	27	7.87e-01	8.75e-01	0.0730	-0.021200	0.06990	8.49e-01	5.30e-01
REACTOME SIGNALING BY ERBB2	68	6.42e-01	7.66e-01	0.0697	-0.030300	-0.06280	6.66e-01	3.72e-01
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	21	8.57e-01	9.17e-01	0.0687	0.003660	-0.06860	9.77e-01	5.87e-01
REACTOME CHOLESTEROL BIOSYNTHESIS	13	9.05e-01	9.44e-01	0.0683	0.016600	-0.06630	9.18e-01	6.79e-01
REACTOME GAB1 SIGNALOSOME	31	8.07e-01	8.86e-01	0.0666	0.066400	-0.00422	5.22e-01	9.68e-01
REACTOME METABOLISM OF NON CODING RNA	42	7.33e-01	8.28e-01	0.0660	-0.027200	0.06010	7.60e-01	5.01e-01
REACTOME MITOTIC PROMETAPHASE	44	7.77e-01	8.66e-01	0.0659	-0.034000	-0.05640	6.97e-01	5.18e-01
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	11	9.26e-01	9.59e-01	0.0656	-0.011500	0.06460	9.47e-01	7.11e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	11	9.34e-01	9.63e-01	0.0632	-0.002920	0.06310	9.87e-01	7.17e-01
REACTOME PLC BETA MEDIATED EVENTS	20	9.01e-01	9.43e-01	0.0622	-0.026400	-0.05630	8.38e-01	6.63e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES	17	8.95e-01	9.40e-01	0.0608	-0.040800	0.04510	7.71e-01	7.48e-01
REACTOME CD28 CO STIMULATION	22	8.73e-01	9.24e-01	0.0607	-0.021100	0.05690	8.64e-01	6.44e-01
REACTOME INSULIN SYNTHESIS AND PROCESSING	13	9.41e-01	9.66e-01	0.0597	0.033300	0.04950	8.35e-01	7.58e-01
REACTOME PI METABOLISM	37	8.04e-01	8.86e-01	0.0590	-0.022400	0.05460	8.14e-01	5.66e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	39	8.17e-01	8.90e-01	0.0584	0.001250	0.05840	9.89e-01	5.28e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	16	9.34e-01	9.63e-01	0.0561	-0.051300	-0.02280	7.23e-01	8.75e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS	36	8.38e-01	9.06e-01	0.0548	0.013300	-0.05310	8.91e-01	5.82e-01
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	36	8.52e-01	9.17e-01	0.0533	-0.004640	0.05310	9.62e-01	5.82e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	32	8.56e-01	9.17e-01	0.0528	0.044200	-0.02880	6.65e-01	7.78e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI	14	9.50e-01	9.66e-01	0.0528	-0.043900	-0.02930	7.76e-01	8.49e-01
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	279	2.99e-01	4.97e-01	0.0523	0.051100	-0.01090	1.45e-01	7.55e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	28	9.06e-01	9.44e-01	0.0522	-0.036800	-0.03700	7.36e-01	7.35e-01
REACTOME PROTEIN FOLDING	40	8.67e-01	9.21e-01	0.0514	0.021400	0.04670	8.15e-01	6.09e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	44	8.58e-01	9.17e-01	0.0513	-0.043500	-0.02720	6.18e-01	7.55e-01
REACTOME BOTULINUM NEUROTOXICITY	10	9.67e-01	9.75e-01	0.0509	-0.032800	-0.03890	8.57e-01	8.31e-01
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	10	9.67e-01	9.75e-01	0.0509	-0.032800	-0.03890	8.57e-01	8.31e-01
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	14	9.45e-01	9.66e-01	0.0498	-0.048700	0.01020	7.52e-01	9.47e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	13	9.50e-01	9.66e-01	0.0475	-0.036100	0.03090	8.22e-01	8.47e-01
REACTOME SIGNALING BY INSULIN RECEPTOR	74	8.11e-01	8.86e-01	0.0466	0.026300	0.03840	6.96e-01	5.69e-01
REACTOME APOPTOTIC EXECUTION PHASE	27	9.20e-01	9.55e-01	0.0462	-0.045300	-0.00919	6.84e-01	9.34e-01
REACTOME DAG AND IP3 SIGNALING	16	9.46e-01	9.66e-01	0.0455	0.016900	-0.04220	9.07e-01	7.70e-01
REACTOME CA DEPENDENT EVENTS	14	9.59e-01	9.73e-01	0.0440	-0.043900	0.00292	7.76e-01	9.85e-01
REACTOME IRON UPTAKE AND TRANSPORT	23	9.46e-01	9.66e-01	0.0415	-0.013300	-0.03930	9.12e-01	7.44e-01
REACTOME PHOSPHOLIPID METABOLISM	114	8.06e-01	8.86e-01	0.0383	0.024300	0.02950	6.55e-01	5.88e-01
REACTOME SIGNALING BY EGFR IN CANCER	82	8.68e-01	9.21e-01	0.0342	-0.034000	-0.00351	5.95e-01	9.56e-01
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	17	9.78e-01	9.84e-01	0.0312	-0.028500	-0.01270	8.39e-01	9.28e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	13	9.83e-01	9.87e-01	0.0277	0.020200	-0.01890	9.00e-01	9.06e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	60	9.66e-01	9.75e-01	0.0184	-0.008970	0.01600	9.05e-01	8.30e-01
REACTOME ION CHANNEL TRANSPORT	18	9.95e-01	9.97e-01	0.0133	-0.005060	0.01230	9.70e-01	9.28e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	17	9.97e-01	9.97e-01	0.0120	-0.010900	-0.00502	9.38e-01	9.71e-01

---

Detailed Gene set reports

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

metric	value
setSize	13
pMANOVA	1.64e-06
p.adjustMANOVA	3.07e-05
s.dist	0.845
s.ctrl	0.824
s.AcyKD	0.189
p.ctrl	2.67e-07
p.AcyKD	0.238

Top 20 genes

Gene	ctrl	AcyKD
Hadhb	4466	4100
Hadh	4153	3872
Decr1	4319	1895
Pccb	1634	3464
Hadha	4320	888
Acadl	4373	440
Acadm	4389	396
Pcca	1421	914
Acads	2444	470
Echs1	4031	155
Acadvl	4440	58

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Acadl	4373	440
Acadm	4389	396
Acads	2444	470
Acadvl	4440	58
Decr1	4319	1895
Echs1	4031	155
Eci1	4250	-3589
Hadh	4153	3872
Hadha	4320	888
Hadhb	4466	4100
Mcee	4356	-1853
Pcca	1421	914
Pccb	1634	3464

---

---

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

metric	value
setSize	19
pMANOVA	9.61e-09
p.adjustMANOVA	3.75e-07
s.dist	0.828
s.ctrl	0.799
s.AcyKD	0.217
p.ctrl	1.62e-09
p.AcyKD	0.102

Top 20 genes

Gene	ctrl	AcyKD
Dld	4413	3856
Idh3b	4352	3581
Sdha	4272	3448
Fh1	4290	3205
Idh3a	4090	2912
Sucla2	4189	2521
Suclg2	3491	2733
Aco2	4208	1453
Cs	2822	592
Suclg1	1030	1440
Sdhc	3194	291
Nnt	1150	27

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Aco2	4208	1453
Cs	2822	592
Dld	4413	3856
Dlst	3761	-303
Fh1	4290	3205
Idh2	3878	-1687
Idh3a	4090	2912
Idh3b	4352	3581
Idh3g	3598	-493
Mdh2	3927	-549
Nnt	1150	27
Ogdh	3954	-13
Sdha	4272	3448
Sdhb	4191	-2800
Sdhc	3194	291
Sdhd	3980	-1410
Sucla2	4189	2521
Suclg1	1030	1440
Suclg2	3491	2733

---

---

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING

metric	value
setSize	12
pMANOVA	6.06e-06
p.adjustMANOVA	7.49e-05
s.dist	0.826
s.ctrl	0.817
s.AcyKD	0.124
p.ctrl	9.49e-07
p.AcyKD	0.458

Top 20 genes

Gene	ctrl	AcyKD
Atp5a1	4361	4007
Atp5b	4311	2980
Atp5j	4158	2692
Atp5j2	3972	2355
Atp5o	4034	1965
Atp5d	3806	1301
Atp5c1	3956	872

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Atp5a1	4361	4007
Atp5b	4311	2980
Atp5c1	3956	872
Atp5d	3806	1301
Atp5e	1785	-1599
Atp5g1	3345	-1809
Atp5h	4231	-1067
Atp5j	4158	2692
Atp5j2	3972	2355
Atp5k	3319	-4104
Atp5l	3198	-861
Atp5o	4034	1965

---

---

REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION

REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION

metric	value
setSize	10
pMANOVA	0.000184
p.adjustMANOVA	0.00151
s.dist	0.78
s.ctrl	0.751
s.AcyKD	0.21
p.ctrl	3.92e-05
p.AcyKD	0.25

Top 20 genes

Gene	ctrl	AcyKD
Aldh18a1	4134	4565
Gpt2	3846	4593
Glud1	3874	3928
Oat	3307	2307
Glul	2523	2606

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Aldh18a1	4134	4565
Gls	503	-1578
Glud1	3874	3928
Glul	2523	2606
Got1	4340	-3319
Got2	4107	-1271
Gpt	4461	-14
Gpt2	3846	4593
Oat	3307	2307
Psph	2917	-2208

---

---

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

metric	value
setSize	11
pMANOVA	0.000162
p.adjustMANOVA	0.00135
s.dist	0.762
s.ctrl	0.7
s.AcyKD	0.301
p.ctrl	5.78e-05
p.AcyKD	0.0836

Top 20 genes

Gene	ctrl	AcyKD
Dld	4413	3856
Pdhb	4500	3709
Pdha1	4381	2984
Pdp2	3137	3065
Pdk4	4513	1538
Pdk1	3473	1766
Pdhx	2936	837

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Dlat	3597	-2446
Dld	4413	3856
Pdha1	4381	2984
Pdhb	4500	3709
Pdhx	2936	837
Pdk1	3473	1766
Pdk2	1344	-605
Pdk4	4513	1538
Pdp1	-1143	1087
Pdp2	3137	3065
Pdpr	3677	-582

---

---

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

metric	value
setSize	73
pMANOVA	3.56e-24
p.adjustMANOVA	8.34e-22
s.dist	0.711
s.ctrl	0.703
s.AcyKD	0.105
p.ctrl	2.7e-25
p.AcyKD	0.12

Top 20 genes

Gene	ctrl	AcyKD
Ucp3	4558	4613
Ndufs1	4516	4289
Atp5a1	4361	4007
Uqcrc2	4429	3821
Ndufa9	4277	3760
Ndufv2	4324	3551
Sdha	4272	3448
Cox7a2l	3163	4342
Atp5b	4311	2980
Atp5j	4158	2692
Ndufs3	3868	2766
Uqcrb	3232	3296
Uqcrfs1	3976	2626
Atp5j2	3972	2355
Ndufc2	3065	2947
Ndufa13	2521	3232
Atp5o	4034	1965
Ndufa12	3600	2186
Ndufs8	3511	2050
Cox6a1	2150	3285

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Atp5a1	4361	4007
Atp5b	4311	2980
Atp5c1	3956	872
Atp5d	3806	1301
Atp5e	1785	-1599
Atp5g1	3345	-1809
Atp5h	4231	-1067
Atp5j	4158	2692
Atp5j2	3972	2355
Atp5k	3319	-4104
Atp5l	3198	-861
Atp5o	4034	1965
Cox4i1	3085	-1838
Cox5a	2893	695
Cox6a1	2150	3285
Cox6b1	3441	-129
Cox6c	3813	-1362
Cox7a2l	3163	4342
Cox7c	3115	389
Cox8a	1098	1341
Cyc1	3294	1329
Cycs	3899	1625
Etfa	4037	-925
Etfb	4009	297
Etfdh	4210	-2448
Ndufa1	1912	-1329
Ndufa10	3325	269
Ndufa11	3565	-878
Ndufa12	3600	2186
Ndufa13	2521	3232
Ndufa2	1920	-2638
Ndufa3	-387	-2883
Ndufa4	3646	-1397
Ndufa5	4390	13
Ndufa6	3106	1681
Ndufa7	1811	1078
Ndufa8	4066	-3619
Ndufa9	4277	3760
Ndufab1	2579	-1600
Ndufb10	2941	-3362
Ndufb2	1672	1116
Ndufb3	3718	-250
Ndufb4	570	560
Ndufb5	3853	1237
Ndufb6	2831	1547
Ndufb7	4398	-653
Ndufb9	4121	-1011
Ndufc1	1590	-3048
Ndufc2	3065	2947
Ndufs1	4516	4289
Ndufs2	2990	1663
Ndufs3	3868	2766
Ndufs4	2755	-10
Ndufs5	3613	-368
Ndufs6	3489	1761
Ndufs7	1404	-1677
Ndufs8	3511	2050
Ndufv1	4181	87
Ndufv2	4324	3551
Ndufv3	155	-3487
Sdha	4272	3448
Sdhb	4191	-2800
Sdhc	3194	291
Sdhd	3980	-1410
Ucp2	-3593	2682
Ucp3	4558	4613
Uqcr11	3245	-1032
Uqcrb	3232	3296
Uqcrc1	2160	-1681
Uqcrc2	4429	3821
Uqcrfs1	3976	2626
Uqcrh	3383	1892
Uqcrq	2877	-2143

---

---

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

metric	value
setSize	107
pMANOVA	1.04e-33
p.adjustMANOVA	4.85e-31
s.dist	0.704
s.ctrl	0.687
s.AcyKD	0.155
p.ctrl	1.02e-34
p.AcyKD	0.00582

Top 20 genes

Gene	ctrl	AcyKD
Ucp3	4558	4613
Ndufs1	4516	4289
Atp5a1	4361	4007
Dld	4413	3856
Uqcrc2	4429	3821
Pdhb	4500	3709
Ndufa9	4277	3760
Idh3b	4352	3581
Ndufv2	4324	3551
Sdha	4272	3448
Idh1	4055	3456
Fh1	4290	3205
Cox7a2l	3163	4342
Pdha1	4381	2984
Atp5b	4311	2980
Idh3a	4090	2912
Atp5j	4158	2692
Ndufs3	3868	2766
Uqcrb	3232	3296
Sucla2	4189	2521

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Aco2	4208	1453
Adhfe1	3890	1693
Atp5a1	4361	4007
Atp5b	4311	2980
Atp5c1	3956	872
Atp5d	3806	1301
Atp5e	1785	-1599
Atp5g1	3345	-1809
Atp5h	4231	-1067
Atp5j	4158	2692
Atp5j2	3972	2355
Atp5k	3319	-4104
Atp5l	3198	-861
Atp5o	4034	1965
Bsg	1335	-2925
Cox4i1	3085	-1838
Cox5a	2893	695
Cox6a1	2150	3285
Cox6b1	3441	-129
Cox6c	3813	-1362
Cox7a2l	3163	4342
Cox7c	3115	389
Cox8a	1098	1341
Cs	2822	592
Cyc1	3294	1329
Cycs	3899	1625
D2hgdh	-3763	694
Dlat	3597	-2446
Dld	4413	3856
Dlst	3761	-303
Etfa	4037	-925
Etfb	4009	297
Etfdh	4210	-2448
Fh1	4290	3205
Idh1	4055	3456
Idh2	3878	-1687
Idh3a	4090	2912
Idh3b	4352	3581
Idh3g	3598	-493
L2hgdh	3884	1955
Ldha	-1198	2709
Ldhb	3631	-620
Mdh2	3927	-549
Ndufa1	1912	-1329
Ndufa10	3325	269
Ndufa11	3565	-878
Ndufa12	3600	2186
Ndufa13	2521	3232
Ndufa2	1920	-2638
Ndufa3	-387	-2883
Ndufa4	3646	-1397
Ndufa5	4390	13
Ndufa6	3106	1681
Ndufa7	1811	1078
Ndufa8	4066	-3619
Ndufa9	4277	3760
Ndufab1	2579	-1600
Ndufb10	2941	-3362
Ndufb2	1672	1116
Ndufb3	3718	-250
Ndufb4	570	560
Ndufb5	3853	1237
Ndufb6	2831	1547
Ndufb7	4398	-653
Ndufb9	4121	-1011
Ndufc1	1590	-3048
Ndufc2	3065	2947
Ndufs1	4516	4289
Ndufs2	2990	1663
Ndufs3	3868	2766
Ndufs4	2755	-10
Ndufs5	3613	-368
Ndufs6	3489	1761
Ndufs7	1404	-1677
Ndufs8	3511	2050
Ndufv1	4181	87
Ndufv2	4324	3551
Ndufv3	155	-3487
Nnt	1150	27
Ogdh	3954	-13
Pdha1	4381	2984
Pdhb	4500	3709
Pdhx	2936	837
Pdk1	3473	1766
Pdk2	1344	-605
Pdk4	4513	1538
Pdp1	-1143	1087
Pdp2	3137	3065
Pdpr	3677	-582
Sdha	4272	3448
Sdhb	4191	-2800
Sdhc	3194	291
Sdhd	3980	-1410
Slc16a1	4498	232
Slc16a3	-1551	2276
Sucla2	4189	2521
Suclg1	1030	1440
Suclg2	3491	2733
Ucp2	-3593	2682
Ucp3	4558	4613
Uqcr11	3245	-1032
Uqcrb	3232	3296
Uqcrc1	2160	-1681
Uqcrc2	4429	3821
Uqcrfs1	3976	2626
Uqcrh	3383	1892
Uqcrq	2877	-2143

---

---

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

metric	value
setSize	38
pMANOVA	4.16e-12
p.adjustMANOVA	2.43e-10
s.dist	0.704
s.ctrl	0.666
s.AcyKD	0.229
p.ctrl	1.19e-12
p.AcyKD	0.0149

Top 20 genes

Gene	ctrl	AcyKD
Dld	4413	3856
Pdhb	4500	3709
Idh3b	4352	3581
Sdha	4272	3448
Idh1	4055	3456
Fh1	4290	3205
Pdha1	4381	2984
Idh3a	4090	2912
Sucla2	4189	2521
Pdp2	3137	3065
Suclg2	3491	2733
L2hgdh	3884	1955
Pdk4	4513	1538
Adhfe1	3890	1693
Pdk1	3473	1766
Aco2	4208	1453
Pdhx	2936	837
Cs	2822	592
Suclg1	1030	1440
Slc16a1	4498	232

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Aco2	4208	1453
Adhfe1	3890	1693
Bsg	1335	-2925
Cs	2822	592
D2hgdh	-3763	694
Dlat	3597	-2446
Dld	4413	3856
Dlst	3761	-303
Fh1	4290	3205
Idh1	4055	3456
Idh2	3878	-1687
Idh3a	4090	2912
Idh3b	4352	3581
Idh3g	3598	-493
L2hgdh	3884	1955
Ldha	-1198	2709
Ldhb	3631	-620
Mdh2	3927	-549
Nnt	1150	27
Ogdh	3954	-13
Pdha1	4381	2984
Pdhb	4500	3709
Pdhx	2936	837
Pdk1	3473	1766
Pdk2	1344	-605
Pdk4	4513	1538
Pdp1	-1143	1087
Pdp2	3137	3065
Pdpr	3677	-582
Sdha	4272	3448
Sdhb	4191	-2800
Sdhc	3194	291
Sdhd	3980	-1410
Slc16a1	4498	232
Slc16a3	-1551	2276
Sucla2	4189	2521
Suclg1	1030	1440
Suclg2	3491	2733

---

---

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

metric	value
setSize	59
pMANOVA	2.07e-19
p.adjustMANOVA	3.22e-17
s.dist	0.702
s.ctrl	0.697
s.AcyKD	0.078
p.ctrl	1.88e-20
p.AcyKD	0.301

Top 20 genes

Gene	ctrl	AcyKD
Ndufs1	4516	4289
Uqcrc2	4429	3821
Ndufa9	4277	3760
Ndufv2	4324	3551
Sdha	4272	3448
Cox7a2l	3163	4342
Ndufs3	3868	2766
Uqcrb	3232	3296
Uqcrfs1	3976	2626
Ndufc2	3065	2947
Ndufa13	2521	3232
Ndufa12	3600	2186
Ndufs8	3511	2050
Cox6a1	2150	3285
Uqcrh	3383	1892
Cycs	3899	1625
Ndufs6	3489	1761
Ndufa6	3106	1681
Ndufs2	2990	1663
Ndufb5	3853	1237

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Cox4i1	3085	-1838
Cox5a	2893	695
Cox6a1	2150	3285
Cox6b1	3441	-129
Cox6c	3813	-1362
Cox7a2l	3163	4342
Cox7c	3115	389
Cox8a	1098	1341
Cyc1	3294	1329
Cycs	3899	1625
Etfa	4037	-925
Etfb	4009	297
Etfdh	4210	-2448
Ndufa1	1912	-1329
Ndufa10	3325	269
Ndufa11	3565	-878
Ndufa12	3600	2186
Ndufa13	2521	3232
Ndufa2	1920	-2638
Ndufa3	-387	-2883
Ndufa4	3646	-1397
Ndufa5	4390	13
Ndufa6	3106	1681
Ndufa7	1811	1078
Ndufa8	4066	-3619
Ndufa9	4277	3760
Ndufab1	2579	-1600
Ndufb10	2941	-3362
Ndufb2	1672	1116
Ndufb3	3718	-250
Ndufb4	570	560
Ndufb5	3853	1237
Ndufb6	2831	1547
Ndufb7	4398	-653
Ndufb9	4121	-1011
Ndufc1	1590	-3048
Ndufc2	3065	2947
Ndufs1	4516	4289
Ndufs2	2990	1663
Ndufs3	3868	2766
Ndufs4	2755	-10
Ndufs5	3613	-368
Ndufs6	3489	1761
Ndufs7	1404	-1677
Ndufs8	3511	2050
Ndufv1	4181	87
Ndufv2	4324	3551
Ndufv3	155	-3487
Sdha	4272	3448
Sdhb	4191	-2800
Sdhc	3194	291
Sdhd	3980	-1410
Uqcr11	3245	-1032
Uqcrb	3232	3296
Uqcrc1	2160	-1681
Uqcrc2	4429	3821
Uqcrfs1	3976	2626
Uqcrh	3383	1892
Uqcrq	2877	-2143

---

---

REACTOME_PYRUVATE_METABOLISM

REACTOME_PYRUVATE_METABOLISM

metric	value
setSize	16
pMANOVA	0.000204
p.adjustMANOVA	0.00165
s.dist	0.622
s.ctrl	0.577
s.AcyKD	0.231
p.ctrl	6.38e-05
p.AcyKD	0.11

Top 20 genes

Gene	ctrl	AcyKD
Dld	4413	3856
Pdhb	4500	3709
Pdha1	4381	2984
Pdp2	3137	3065
Pdk4	4513	1538
Pdk1	3473	1766
Pdhx	2936	837
Slc16a1	4498	232

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Bsg	1335	-2925
Dlat	3597	-2446
Dld	4413	3856
Ldha	-1198	2709
Ldhb	3631	-620
Pdha1	4381	2984
Pdhb	4500	3709
Pdhx	2936	837
Pdk1	3473	1766
Pdk2	1344	-605
Pdk4	4513	1538
Pdp1	-1143	1087
Pdp2	3137	3065
Pdpr	3677	-582
Slc16a1	4498	232
Slc16a3	-1551	2276

---

---

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

metric	value
setSize	11
pMANOVA	0.00192
p.adjustMANOVA	0.0118
s.dist	0.617
s.ctrl	0.054
s.AcyKD	0.615
p.ctrl	0.757
p.AcyKD	0.000415

Top 20 genes

Gene	ctrl	AcyKD
Phka2	3845	4269
Gyg	3144	2549
Phkb	468	4341
Phkg2	519	3138
Phkg1	219	3782
Phka1	176	4364
Agl	111	4345

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Agl	111	4345
Calm1	-607	-189
Gyg	3144	2549
Pgm1	-1411	2868
Phka1	176	4364
Phka2	3845	4269
Phkb	468	4341
Phkg1	219	3782
Phkg2	519	3138
Pygb	-3494	-2463
Pygm	-1032	4157

---

---

REACTOME_COMPLEMENT_CASCADE

REACTOME_COMPLEMENT_CASCADE

metric	value
setSize	11
pMANOVA	0.000972
p.adjustMANOVA	0.00641
s.dist	0.6
s.ctrl	-0.495
s.AcyKD	0.34
p.ctrl	0.00451
p.AcyKD	0.051

Top 20 genes

Gene	ctrl	AcyKD
C1qb	-3962	4183
C1qa	-2937	4550
C3	-4329	2836
C4b	-3609	1975
C1qc	-645	4559
Cr1l	-2643	1012
Cfd	-3747	378
Cd46	-59	4479

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
C1qa	-2937	4550
C1qb	-3962	4183
C1qc	-645	4559
C1s1	-1854	-2979
C3	-4329	2836
C4b	-3609	1975
C7	649	-2283
Cd46	-59	4479
Cfd	-3747	378
Cr1l	-2643	1012
Pros1	-2844	-1539

---

---

REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

metric	value
setSize	10
pMANOVA	0.0097
p.adjustMANOVA	0.0461
s.dist	0.595
s.ctrl	-0.472
s.AcyKD	-0.362
p.ctrl	0.00972
p.AcyKD	0.0476

Top 20 genes

Gene	ctrl	AcyKD
Hsp90aa1	-3164	-3950
Plxna2	-2982	-3743
Fyn	-3733	-2973
Pak2	-2664	-2943
Plxna1	-4350	-1154
Rac1	-3027	-251

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Cfl1	-4429	1344
Fyn	-3733	-2973
Hsp90aa1	-3164	-3950
Hsp90ab1	-2942	1517
Nrp1	4058	-3839
Pak1	646	-865
Pak2	-2664	-2943
Plxna1	-4350	-1154
Plxna2	-2982	-3743
Rac1	-3027	-251

---

---

REACTOME_PEPTIDE_CHAIN_ELONGATION

REACTOME_PEPTIDE_CHAIN_ELONGATION

metric	value
setSize	67
pMANOVA	1.65e-14
p.adjustMANOVA	1.55e-12
s.dist	0.53
s.ctrl	-0.496
s.AcyKD	0.189
p.ctrl	2.42e-12
p.AcyKD	0.00748

Top 20 genes

Gene	ctrl	AcyKD
Rpl12	-3702	4581
Eef1a1	-4412	3808
Rps16	-4186	3466
Rps26	-4180	3346
Rpl5	-3054	4180
Rps3	-4112	3071
Rps20	-4500	2735
Rpl37a	-3282	3355
Rps4x	-3008	3564
Rplp0	-4266	2305
Rps8	-3059	3170
Rps7	-3555	2643
Rpl4	-3278	2862
Rps3a1	-2034	4081
Rpl38	-2733	2650
Rps14	-3976	1790
Rpl23	-2342	2690
Rpsa	-2169	2893
Rps5	-2212	2529
Rpl18a	-1211	4426

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Eef1a1	-4412.0	3808.0
Eef2	-701.0	4460.0
Rpl10a	1121.0	1507.0
Rpl11	-2828.0	1101.0
Rpl12	-3702.0	4581.0
Rpl13	596.0	3556.0
Rpl14	-4072.0	-2824.0
Rpl15	-422.0	145.0
Rpl18	-3021.0	830.0
Rpl18a	-1211.0	4426.0
Rpl19	-3373.0	-441.0
Rpl22	-1933.0	1263.0
Rpl23	-2342.0	2690.0
Rpl23a	-1469.0	-227.0
Rpl24	-177.0	-1425.0
Rpl26	-964.0	2651.0
Rpl27-ps3	379.5	-3414.5
Rpl27a	-3969.0	-2763.0
Rpl28	-2213.0	936.0
Rpl29	159.0	619.0
Rpl3	-4501.0	-2250.0
Rpl30	-2227.0	1928.0
Rpl32	-3761.0	-2351.0
Rpl34	-3543.0	30.0
Rpl35	487.0	1260.0
Rpl36al	2480.0	3912.0
Rpl37	-149.0	-1606.0
Rpl37a	-3282.0	3355.0
Rpl38	-2733.0	2650.0
Rpl39	-3209.0	-2749.0
Rpl3l	2793.0	-2167.0
Rpl4	-3278.0	2862.0
Rpl41	-3679.0	-3137.0
Rpl5	-3054.0	4180.0
Rpl6	-2095.0	2537.0
Rpl8	-3311.0	-743.0
Rplp0	-4266.0	2305.0
Rplp1	-2158.0	1851.0
Rplp2	-1425.0	-819.0
Rps11	-3297.0	1463.0
Rps12-ps3	647.0	326.0
Rps13	-2888.0	-1100.0
Rps14	-3976.0	1790.0
Rps15a	-4073.0	-2021.0
Rps16	-4186.0	3466.0
Rps17	-1328.0	3414.0
Rps18	-3908.0	381.0
Rps19	-3711.0	517.0
Rps20	-4500.0	2735.0
Rps21	-2468.0	-4216.0
Rps23	-3039.0	1482.0
Rps24	-3167.0	1026.0
Rps25	-3017.0	134.0
Rps26	-4180.0	3346.0
Rps27	-3613.0	-3831.0
Rps27a	-3651.0	-1238.0
Rps29	205.0	-4120.0
Rps3	-4112.0	3071.0
Rps3a1	-2034.0	4081.0
Rps4x	-3008.0	3564.0
Rps5	-2212.0	2529.0
Rps6	-3395.0	732.0
Rps7	-3555.0	2643.0
Rps8	-3059.0	3170.0
Rps9	-4080.0	-913.0
Rpsa	-2169.0	2893.0
Uba52	-356.0	-284.0

---

---

REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION

REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION

metric	value
setSize	22
pMANOVA	0.000554
p.adjustMANOVA	0.00393
s.dist	0.511
s.ctrl	0.324
s.AcyKD	0.395
p.ctrl	0.00858
p.AcyKD	0.00134

Top 20 genes

Gene	ctrl	AcyKD
Eprs	4156	4598
Lars	3802	4529
Aars	3535	3775
Farsb	3250	3623
Rars	2541	4421
Aimp2	2706	3491
Nars	2453	3310
Cars	3532	2018
Sars	3574	1765
Iars	3344	1330
Aimp1	1845	2167
Yars	3528	972
Ppa1	242	1407

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Aars	3535	3775
Aimp1	1845	2167
Aimp2	2706	3491
Cars	3532	2018
Dars	3347	-961
Eprs	4156	4598
Farsa	-3348	-2302
Farsb	3250	3623
Gars	-1910	1584
Hars	-656	-1837
Iars	3344	1330
Kars	3053	-1612
Lars	3802	4529
Nars	2453	3310
Ppa1	242	1407
Qars	-2753	3244
Rars	2541	4421
Sars	3574	1765
Tars	-891	4530
Vars	-3422	746
Wars	-615	-863
Yars	3528	972

---

---

REACTOME_SIGNALING_BY_NOTCH4

REACTOME_SIGNALING_BY_NOTCH4

metric	value
setSize	11
pMANOVA	0.0241
p.adjustMANOVA	0.0909
s.dist	0.508
s.ctrl	-0.302
s.AcyKD	-0.409
p.ctrl	0.0829
p.AcyKD	0.0189

Top 20 genes

Gene	ctrl	AcyKD
Jag2	-4172	-3543
Adam10	-2771	-3978
Dll4	-3264	-3166
Jag1	-2210	-2526
Ncstn	-1180	-3188
Psenen	-1696	-1239

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Adam10	-2771	-3978
Aph1a	1136	-300
Aph1b	1542	-3677
Dll4	-3264	-3166
Jag1	-2210	-2526
Jag2	-4172	-3543
Ncstn	-1180	-3188
Notch4	-2222	123
Psen1	804	386
Psen2	-2148	181
Psenen	-1696	-1239

---

---

REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI

REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI

metric	value
setSize	13
pMANOVA	0.0129
p.adjustMANOVA	0.0591
s.dist	0.501
s.ctrl	-0.254
s.AcyKD	-0.432
p.ctrl	0.113
p.AcyKD	0.00699

Top 20 genes

Gene	ctrl	AcyKD
Sema6d	-4425	-4014
Pigm	-4229	-3251
Pign	-4201	-2271
Pigv	-2610	-3322
Pigx	-1698	-4541
Pigw	-2460	-2442
Dpm2	-3349	-1576
Pigb	-532	-3246
Pigc	-197	-904

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Dpm2	-3349	-1576
Pigb	-532	-3246
Pigc	-197	-904
Pigg	1702	-1363
Pigm	-4229	-3251
Pign	-4201	-2271
Pigo	4005	-420
Pigp	540	-642
Pigq	1208	1854
Pigv	-2610	-3322
Pigw	-2460	-2442
Pigx	-1698	-4541
Sema6d	-4425	-4014

---

---

REACTOME_SIGNALING_BY_NOTCH2

REACTOME_SIGNALING_BY_NOTCH2

metric	value
setSize	11
pMANOVA	0.0281
p.adjustMANOVA	0.102
s.dist	0.499
s.ctrl	-0.34
s.AcyKD	-0.366
p.ctrl	0.0511
p.AcyKD	0.0355

Top 20 genes

Gene	ctrl	AcyKD
Jag2	-4172	-3543
Adam10	-2771	-3978
Dll4	-3264	-3166
Jag1	-2210	-2526
Ncstn	-1180	-3188
Psenen	-1696	-1239

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Adam10	-2771	-3978
Aph1a	1136	-300
Aph1b	1542	-3677
Dll4	-3264	-3166
Jag1	-2210	-2526
Jag2	-4172	-3543
Ncstn	-1180	-3188
Notch2	-4139	2289
Psen1	804	386
Psen2	-2148	181
Psenen	-1696	-1239

---

---

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

metric	value
setSize	42
pMANOVA	4.56e-07
p.adjustMANOVA	1.19e-05
s.dist	0.496
s.ctrl	0.478
s.AcyKD	0.132
p.ctrl	8.25e-08
p.AcyKD	0.139

Top 20 genes

Gene	ctrl	AcyKD
Mtx2	4294	4394
Atp5a1	4361	4007
Hspa9	4411	3114
Atp5b	4311	2980
Slc25a4	4104	2685
Timm8b	2747	3646
Slc25a12	4106	2086
Samm50	3662	2089
Timm10	4234	1740
Timm44	4062	1539
Aco2	4208	1453
Vdac1	3375	1776
Cyc1	3294	1329
Grpel1	4223	953
Pmpcb	2288	1657
Timm9	4364	543
Hspd1	3743	590
Cs	2822	592
Timm23	661	1817
Timm22	1140	939

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Aco2	4208	1453
Atp5a1	4361	4007
Atp5b	4311	2980
Atp5g1	3345	-1809
Bcs1l	2884	-2216
Coq2	-2182	1966
Cs	2822	592
Cyc1	3294	1329
Dnajc19	-635	2686
Fxn	-1285	947
Gfer	1743	-3316
Grpel1	4223	953
Grpel2	1155	-1386
Hscb	-1784	-4284
Hspa9	4411	3114
Hspd1	3743	590
Idh3g	3598	-493
Ldhd	-2294	-2258
Mtx1	-1005	-1445
Mtx2	4294	4394
Pmpca	187	1863
Pmpcb	2288	1657
Samm50	3662	2089
Slc25a12	4106	2086
Slc25a4	4104	2685
Timm10	4234	1740
Timm13	-967	-915
Timm17a	4383	-127
Timm17b	-3074	3636
Timm22	1140	939
Timm23	661	1817
Timm44	4062	1539
Timm50	2604	-869
Timm8a1	4431	-4416
Timm8b	2747	3646
Timm9	4364	543
Tomm20	1492	211
Tomm22	413	1144
Tomm40	623	1671
Tomm5	3399	-2206
Tomm7	2124	-3218
Vdac1	3375	1776

---

---

REACTOME_NCAM1_INTERACTIONS

REACTOME_NCAM1_INTERACTIONS

metric	value
setSize	15
pMANOVA	0.00161
p.adjustMANOVA	0.01
s.dist	0.494
s.ctrl	-0.312
s.AcyKD	0.382
p.ctrl	0.0364
p.AcyKD	0.0104

Top 20 genes

Gene	ctrl	AcyKD
Nrtn	-4348	4543
Col6a1	-1981	4503
Col1a1	-3645	1716
Col1a2	-1237	4577
Col6a3	-3211	1659
Col6a2	-1409	3427
Prnp	-2787	1574
Col3a1	-850	4322
Col4a2	-3120	419

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Agrn	-4452	-3753
Cacna1s	1363	-2616
Cacnb1	-598	-1365
Col1a1	-3645	1716
Col1a2	-1237	4577
Col3a1	-850	4322
Col4a1	-274	-406
Col4a2	-3120	419
Col5a1	3182	3359
Col5a2	604	4378
Col6a1	-1981	4503
Col6a2	-1409	3427
Col6a3	-3211	1659
Nrtn	-4348	4543
Prnp	-2787	1574

---

---

REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES

REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES

metric	value
setSize	40
pMANOVA	1.27e-06
p.adjustMANOVA	2.58e-05
s.dist	0.486
s.ctrl	0.0989
s.AcyKD	0.476
p.ctrl	0.28
p.AcyKD	1.96e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Mrc1	-2314	4488
Mrc2	1001	-4193
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775

---

---

REACTOME_SIGNALING_BY_HIPPO

REACTOME_SIGNALING_BY_HIPPO

metric	value
setSize	15
pMANOVA	0.00331
p.adjustMANOVA	0.0191
s.dist	0.486
s.ctrl	-0.478
s.AcyKD	0.0857
p.ctrl	0.00135
p.AcyKD	0.566

Top 20 genes

Gene	ctrl	AcyKD
Ywhab	-4181	2907
Ywhae	-2416	2552
Lats2	-3781	1544
Sav1	-2229	2140
Mob1b	-2116	2036
Amotl2	-3953	736
Tjp1	-3410	529
Dvl2	-479	2869
Mob1a	-1751	719

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Amot	-1672	-1960
Amotl1	789	2340
Amotl2	-3953	736
Dvl2	-479	2869
Lats1	1675	-4223
Lats2	-3781	1544
Mob1a	-1751	719
Mob1b	-2116	2036
Sav1	-2229	2140
Stk4	-2462	0
Tjp1	-3410	529
Wwtr1	-3841	-3303
Yap1	-4441	-3112
Ywhab	-4181	2907
Ywhae	-2416	2552

---

---

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

metric	value
setSize	16
pMANOVA	0.00299
p.adjustMANOVA	0.0175
s.dist	0.481
s.ctrl	0.479
s.AcyKD	-0.04
p.ctrl	0.000909
p.AcyKD	0.782

Top 20 genes

Gene	ctrl	AcyKD
Ivd	3925	-3485
Dbt	3665	-3580
Mccc2	2722	-2227
Hibch	1519	-3862
Hsd17b10	1817	-1225
Hibadh	4220	-305
Bcat2	2224	-377
Acat1	4414	-52

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Acad8	1998	3465
Acadsb	3136	4463
Acat1	4414	-52
Aldh6a1	4546	934
Auh	-1529	-3767
Bcat2	2224	-377
Bckdha	1089	2781
Bckdhb	-2780	-924
Dbt	3665	-3580
Dld	4413	3856
Hibadh	4220	-305
Hibch	1519	-3862
Hsd17b10	1817	-1225
Ivd	3925	-3485
Mccc1	-1107	1165
Mccc2	2722	-2227

---

---

REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1

REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1

metric	value
setSize	42
pMANOVA	9.97e-07
p.adjustMANOVA	2.33e-05
s.dist	0.477
s.ctrl	0.0857
s.AcyKD	0.469
p.ctrl	0.337
p.AcyKD	1.48e-07

Top 20 genes

Gene	ctrl	AcyKD
Btrc	3607	3794
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Btrc	3607	3794
Cul1	-2709	1047
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6

REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6

metric	value
setSize	40
pMANOVA	2.28e-06
p.adjustMANOVA	3.56e-05
s.dist	0.473
s.ctrl	0.0843
s.AcyKD	0.466
p.ctrl	0.357
p.AcyKD	3.49e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

metric	value
setSize	13
pMANOVA	0.00849
p.adjustMANOVA	0.0418
s.dist	0.472
s.ctrl	-0.456
s.AcyKD	0.12
p.ctrl	0.0044
p.AcyKD	0.454

Top 20 genes

Gene	ctrl	AcyKD
Mogs	-3477	3938
Prkcsh	-4532	2483
Calr	-4052	2443
Edem2	-3492	2157
Mlec	-4214	267

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Calr	-4052	2443
Canx	2201	4056
Edem1	-4036	-2316
Edem2	-3492	2157
Edem3	-3114	-953
Ganab	-1834	-2530
Man1b1	-4223	-219
Mlec	-4214	267
Mogs	-3477	3938
Pdia3	-1351	-3849
Prkcsh	-4532	2483
Uggt1	1615	3563
Uggt2	2115	-1968

---

---

REACTOME_SIGNALING_BY_NOTCH3

REACTOME_SIGNALING_BY_NOTCH3

metric	value
setSize	11
pMANOVA	0.0426
p.adjustMANOVA	0.134
s.dist	0.464
s.ctrl	-0.231
s.AcyKD	-0.402
p.ctrl	0.185
p.AcyKD	0.0209

Top 20 genes

Gene	ctrl	AcyKD
Jag2	-4172	-3543
Adam10	-2771	-3978
Dll4	-3264	-3166
Jag1	-2210	-2526
Ncstn	-1180	-3188
Psenen	-1696	-1239

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Adam10	-2771	-3978
Aph1a	1136	-300
Aph1b	1542	-3677
Dll4	-3264	-3166
Jag1	-2210	-2526
Jag2	-4172	-3543
Ncstn	-1180	-3188
Notch3	1394	448
Psen1	804	386
Psen2	-2148	181
Psenen	-1696	-1239

---

---

REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT

REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT

metric	value
setSize	42
pMANOVA	2.23e-06
p.adjustMANOVA	3.56e-05
s.dist	0.462
s.ctrl	0.0789
s.AcyKD	0.455
p.ctrl	0.377
p.AcyKD	3.38e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Atm	1467	1034
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Atm	1467	1034
Cdc25a	-1872	1152
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE

REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE

metric	value
setSize	89
pMANOVA	1.15e-14
p.adjustMANOVA	1.34e-12
s.dist	0.461
s.ctrl	-0.422
s.AcyKD	0.185
p.ctrl	6.08e-12
p.AcyKD	0.00259

Top 20 genes

Gene	ctrl	AcyKD
Srp14	-4497	4117
Rpl12	-3702	4581
Rps16	-4186	3466
Rps26	-4180	3346
Rpl5	-3054	4180
Rps3	-4112	3071
Rps20	-4500	2735
Rpl37a	-3282	3355
Rps4x	-3008	3564
Rplp0	-4266	2305
Rps8	-3059	3170
Rps7	-3555	2643
Rpl4	-3278	2862
Sec61a1	-3252	2881
Rps3a1	-2034	4081
Sec11a	-3132	2391
Rpl38	-2733	2650
Rps14	-3976	1790
Sec11c	-4592	1543
Rpl23	-2342	2690

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Ddost	-3038.0	802.0
Rpl10a	1121.0	1507.0
Rpl11	-2828.0	1101.0
Rpl12	-3702.0	4581.0
Rpl13	596.0	3556.0
Rpl14	-4072.0	-2824.0
Rpl15	-422.0	145.0
Rpl18	-3021.0	830.0
Rpl18a	-1211.0	4426.0
Rpl19	-3373.0	-441.0
Rpl22	-1933.0	1263.0
Rpl23	-2342.0	2690.0
Rpl23a	-1469.0	-227.0
Rpl24	-177.0	-1425.0
Rpl26	-964.0	2651.0
Rpl27-ps3	379.5	-3414.5
Rpl27a	-3969.0	-2763.0
Rpl28	-2213.0	936.0
Rpl29	159.0	619.0
Rpl3	-4501.0	-2250.0
Rpl30	-2227.0	1928.0
Rpl32	-3761.0	-2351.0
Rpl34	-3543.0	30.0
Rpl35	487.0	1260.0
Rpl36al	2480.0	3912.0
Rpl37	-149.0	-1606.0
Rpl37a	-3282.0	3355.0
Rpl38	-2733.0	2650.0
Rpl39	-3209.0	-2749.0
Rpl3l	2793.0	-2167.0
Rpl4	-3278.0	2862.0
Rpl41	-3679.0	-3137.0
Rpl5	-3054.0	4180.0
Rpl6	-2095.0	2537.0
Rpl8	-3311.0	-743.0
Rplp0	-4266.0	2305.0
Rplp1	-2158.0	1851.0
Rplp2	-1425.0	-819.0
Rpn1	-2412.0	-3053.0
Rpn2	-4465.0	1302.0
Rps11	-3297.0	1463.0
Rps12-ps3	647.0	326.0
Rps13	-2888.0	-1100.0
Rps14	-3976.0	1790.0
Rps15a	-4073.0	-2021.0
Rps16	-4186.0	3466.0
Rps17	-1328.0	3414.0
Rps18	-3908.0	381.0
Rps19	-3711.0	517.0
Rps20	-4500.0	2735.0
Rps21	-2468.0	-4216.0
Rps23	-3039.0	1482.0
Rps24	-3167.0	1026.0
Rps25	-3017.0	134.0
Rps26	-4180.0	3346.0
Rps27	-3613.0	-3831.0
Rps27a	-3651.0	-1238.0
Rps29	205.0	-4120.0
Rps3	-4112.0	3071.0
Rps3a1	-2034.0	4081.0
Rps4x	-3008.0	3564.0
Rps5	-2212.0	2529.0
Rps6	-3395.0	732.0
Rps7	-3555.0	2643.0
Rps8	-3059.0	3170.0
Rps9	-4080.0	-913.0
Rpsa	-2169.0	2893.0
Sec11a	-3132.0	2391.0
Sec11c	-4592.0	1543.0
Sec61a1	-3252.0	2881.0
Sec61a2	-694.0	566.0
Sec61b	-4240.0	-3507.0
Sec61g	2705.0	3681.0
Spcs1	3434.0	4057.0
Spcs2	-1169.0	-1428.0
Spcs3	-2132.0	-3245.0
Srp14	-4497.0	4117.0
Srp19	1794.0	3390.0
Srp54a	4459.0	-1168.0
Srp68	1395.0	2191.0
Srp72	1483.0	3392.0
Srp9	-2605.0	23.0
Srprb	-1241.0	515.0
Ssr1	-325.0	93.0
Ssr2	-2436.0	1221.0
Ssr3	452.0	1912.0
Ssr4	-172.0	1743.0
Tram1	-1870.0	1877.0
Uba52	-356.0	-284.0

---

---

REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1

REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1

metric	value
setSize	42
pMANOVA	2.4e-06
p.adjustMANOVA	3.63e-05
s.dist	0.461
s.ctrl	0.078
s.AcyKD	0.454
p.ctrl	0.382
p.AcyKD	3.65e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Atm	1467	1034
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Atm	1467	1034
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Trp53	-2055	901
Uba52	-356	-284

---

---

REACTOME_SIGNALING_BY_ROBO_RECEPTOR

REACTOME_SIGNALING_BY_ROBO_RECEPTOR

metric	value
setSize	20
pMANOVA	0.00394
p.adjustMANOVA	0.0217
s.dist	0.46
s.ctrl	-0.363
s.AcyKD	-0.284
p.ctrl	0.00503
p.AcyKD	0.0282

Top 20 genes

Gene	ctrl	AcyKD
Srgap2	-3918	-3878
Abl1	-4679	-2955
Nck2	-4684	-1827
Evl	-3107	-2712
Pfn1	-3510	-2320
Pak2	-2664	-2943
Pfn2	-4221	-1717
Cap1	-4370	-1300
Enah	-1297	-4205
Sos2	-1355	-3576
Gpc1	-1617	-2137
Rac1	-3027	-251

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Abl1	-4679	-2955
Abl2	2635	-3585
Cap1	-4370	-1300
Cap2	327	1884
Cdc42	-1881	1534
Clasp1	2935	2502
Enah	-1297	-4205
Evl	-3107	-2712
Gpc1	-1617	-2137
Nck1	1755	2427
Nck2	-4684	-1827
Pak1	646	-865
Pak2	-2664	-2943
Pfn1	-3510	-2320
Pfn2	-4221	-1717
Rac1	-3027	-251
Sos1	1741	-2484
Sos2	-1355	-3576
Srgap2	-3918	-3878
Vasp	-4689	1968

---

---

REACTOME_GLUCONEOGENESIS

REACTOME_GLUCONEOGENESIS

metric	value
setSize	18
pMANOVA	0.00719
p.adjustMANOVA	0.0359
s.dist	0.459
s.ctrl	0.326
s.AcyKD	0.323
p.ctrl	0.0166
p.AcyKD	0.0177

Top 20 genes

Gene	ctrl	AcyKD
Pfkfb1	4166	4375
Mdh1	4400	3307
Eno1	2274	4208
Slc25a12	4106	2086
Pgk1	1648	4549
Pcx	1356	4531

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Eno1	2274	4208
Eno3	-411	4326
Fbp2	-3637	4305
Got1	4340	-3319
Got2	4107	-1271
Gpi1	-823	3866
Mdh1	4400	3307
Mdh2	3927	-549
Pcx	1356	4531
Pfkfb1	4166	4375
Pgam1	2924	-1850
Pgam2	-1486	-2198
Pgk1	1648	4549
Prkaca	127	-2073
Prkacb	-4541	1522
Slc25a11	3446	-1112
Slc25a12	4106	2086
Tpi1	-95	1973

---

---

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX

metric	value
setSize	42
pMANOVA	2.93e-07
p.adjustMANOVA	8.56e-06
s.dist	0.452
s.ctrl	-0.354
s.AcyKD	0.281
p.ctrl	7.45e-05
p.AcyKD	0.00165

Top 20 genes

Gene	ctrl	AcyKD
Rps16	-4186	3466
Rps26	-4180	3346
Rps3	-4112	3071
Rps20	-4500	2735
Rps4x	-3008	3564
Rps8	-3059	3170
Rps7	-3555	2643
Rps3a1	-2034	4081
Rps14	-3976	1790
Rpsa	-2169	2893
Rps5	-2212	2529
Rps11	-3297	1463
Rps17	-1328	3414
Rps23	-3039	1482
Rps24	-3167	1026
Rps6	-3395	732
Eif1ax	-1500	1650
Eif3b	-556	3772
Eif3e	-1862	1093
Rps19	-3711	517

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Eif1ax	-1500	1650
Eif2s1	-1569	-2100
Eif2s2	3208	3964
Eif2s3x	2611	3297
Eif3a	4285	4240
Eif3b	-556	3772
Eif3c	3930	4486
Eif3d	-685	1503
Eif3e	-1862	1093
Eif3f	-3044	-1114
Eif3g	3235	2974
Eif3h	-1456	-356
Eif3i	2675	760
Eif3j2	-429	3889
Eif3k	1360	548
Rps11	-3297	1463
Rps12-ps3	647	326
Rps13	-2888	-1100
Rps14	-3976	1790
Rps15a	-4073	-2021
Rps16	-4186	3466
Rps17	-1328	3414
Rps18	-3908	381
Rps19	-3711	517
Rps20	-4500	2735
Rps21	-2468	-4216
Rps23	-3039	1482
Rps24	-3167	1026
Rps25	-3017	134
Rps26	-4180	3346
Rps27	-3613	-3831
Rps27a	-3651	-1238
Rps29	205	-4120
Rps3	-4112	3071
Rps3a1	-2034	4081
Rps4x	-3008	3564
Rps5	-2212	2529
Rps6	-3395	732
Rps7	-3555	2643
Rps8	-3059	3170
Rps9	-4080	-913
Rpsa	-2169	2893

---

---

REACTOME_RAP1_SIGNALLING

REACTOME_RAP1_SIGNALLING

metric	value
setSize	12
pMANOVA	0.0401
p.adjustMANOVA	0.13
s.dist	0.45
s.ctrl	-0.378
s.AcyKD	-0.245
p.ctrl	0.0234
p.AcyKD	0.142

Top 20 genes

Gene	ctrl	AcyKD
Sipa1	-4694	-4315
Rapgef3	-3485	-4588
Rasgrp2	-3656	-2307
Raf1	-3040	-1508
Rap1a	-3378	-111

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Prkaca	127	-2073
Prkacb	-4541	1522
Prkg1	3944	-4425
Raf1	-3040	-1508
Rap1a	-3378	-111
Rap1b	-3137	781
Rap1gap	3682	-3080
Rap1gap2	488	3469
Rapgef3	-3485	-4588
Rasgrp2	-3656	-2307
Sipa1	-4694	-4315
Ywhab	-4181	2907

---

---

REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS

REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS

metric	value
setSize	16
pMANOVA	0.0072
p.adjustMANOVA	0.0359
s.dist	0.45
s.ctrl	-0.0117
s.AcyKD	-0.45
p.ctrl	0.936
p.AcyKD	0.00183

Top 20 genes

Gene	ctrl	AcyKD
S1pr1	-3860	-4628
Cxcl12	-3238	-4138
Adrb2	-4279	-2356
Ccl27a	-2024	-2311
Ccl25	-1181	-2632
Anxa1	-927	-755

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Adrb2	-4279	-2356
Agt	1761	-2977
Anxa1	-927	-755
Aplnr	626	-4238
App	850	1278
C3	-4329	2836
Ccl11	3272	-447
Ccl25	-1181	-2632
Ccl27a	-2024	-2311
Cxcl12	-3238	-4138
Ednrb	1973	-3569
F2r	554	-3017
Lpar1	152	-4505
P2ry1	4334	1756
P2ry2	4275	-3782
S1pr1	-3860	-4628

---

---

REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

metric	value
setSize	20
pMANOVA	0.00501
p.adjustMANOVA	0.0264
s.dist	0.448
s.ctrl	-0.372
s.AcyKD	-0.251
p.ctrl	0.00403
p.AcyKD	0.0522

Top 20 genes

Gene	ctrl	AcyKD
Jag2	-4172	-3543
Arrb1	-4216	-2644
Adam10	-2771	-3978
Dll4	-3264	-3166
Dtx2	-4374	-1653
Jag1	-2210	-2526
Dtx4	-4287	-1186
Rps27a	-3651	-1238
Ncstn	-1180	-3188
Mib2	-1466	-1866
Psenen	-1696	-1239
Uba52	-356	-284

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Adam10	-2771	-3978
Adam17	3922	285
Aph1a	1136	-300
Aph1b	1542	-3677
Arrb1	-4216	-2644
Arrb2	-2325	3571
Dll4	-3264	-3166
Dtx2	-4374	-1653
Dtx4	-4287	-1186
Jag1	-2210	-2526
Jag2	-4172	-3543
Mib1	-2037	471
Mib2	-1466	-1866
Ncstn	-1180	-3188
Numb	-3071	2169
Psen1	804	386
Psen2	-2148	181
Psenen	-1696	-1239
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX

REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX

metric	value
setSize	45
pMANOVA	1.83e-06
p.adjustMANOVA	3.26e-05
s.dist	0.448
s.ctrl	0.0649
s.AcyKD	0.443
p.ctrl	0.452
p.AcyKD	2.75e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Gmnn	2971	2800
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Orc5	2179	2138
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Gmnn	2971	2800
Orc2	-3240	-511
Orc3	-1914	-607
Orc4	-2456	2113
Orc5	2179	2138
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G

REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G

metric	value
setSize	42
pMANOVA	6.93e-06
p.adjustMANOVA	8.32e-05
s.dist	0.446
s.ctrl	0.108
s.AcyKD	0.433
p.ctrl	0.227
p.AcyKD	1.23e-06

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839
Rbx1	1759	194
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Cul5	3452	-2325
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rbx1	1759	194
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC

REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC

metric	value
setSize	43
pMANOVA	5e-06
p.adjustMANOVA	6.87e-05
s.dist	0.444
s.ctrl	0.0893
s.AcyKD	0.435
p.ctrl	0.312
p.AcyKD	8.06e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Nqo1	1927	4253
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Azin1	-757	-4520
Nqo1	1927	4253
Oaz1	-1424	-2619
Oaz2	-1243	-2710
Odc1	-580	4373
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775

---

---

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION

metric	value
setSize	83
pMANOVA	1.54e-12
p.adjustMANOVA	1.03e-10
s.dist	0.44
s.ctrl	-0.402
s.AcyKD	0.178
p.ctrl	2.64e-10
p.AcyKD	0.00516

Top 20 genes

Gene	ctrl	AcyKD
Rpl12	-3702	4581
Rps16	-4186	3466
Rps26	-4180	3346
Rpl5	-3054	4180
Rps3	-4112	3071
Rps20	-4500	2735
Dnajc3	-4115	2780
Rpl37a	-3282	3355
Rps4x	-3008	3564
Rplp0	-4266	2305
Rps8	-3059	3170
Rps7	-3555	2643
Rpl4	-3278	2862
Rps3a1	-2034	4081
Rpl38	-2733	2650
Polr2g	-1796	3973
Rps14	-3976	1790
Rpl23	-2342	2690
Rpsa	-2169	2893
Rps5	-2212	2529

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Dnajc3	-4115.0	2780.0
Grsf1	4388.0	-2380.0
Gtf2f1	1957.0	2053.0
Gtf2f2	1769.0	2714.0
Hsp90aa1	-3164.0	-3950.0
Ipo5	4188.0	4005.0
Polr2a	-3056.0	-93.0
Polr2b	-31.0	2093.0
Polr2c	-1476.0	-34.0
Polr2d	-483.0	1982.0
Polr2e	-1823.0	1140.0
Polr2f	1039.0	3049.0
Polr2g	-1796.0	3973.0
Polr2h	-1974.0	2441.0
Polr2i	396.0	-2999.0
Polr2j	-1835.0	-1802.0
Polr2k	-275.0	1704.0
Polr2l	-436.0	910.0
Rpl10a	1121.0	1507.0
Rpl11	-2828.0	1101.0
Rpl12	-3702.0	4581.0
Rpl13	596.0	3556.0
Rpl14	-4072.0	-2824.0
Rpl15	-422.0	145.0
Rpl18	-3021.0	830.0
Rpl18a	-1211.0	4426.0
Rpl19	-3373.0	-441.0
Rpl22	-1933.0	1263.0
Rpl23	-2342.0	2690.0
Rpl23a	-1469.0	-227.0
Rpl24	-177.0	-1425.0
Rpl26	-964.0	2651.0
Rpl27-ps3	379.5	-3414.5
Rpl27a	-3969.0	-2763.0
Rpl28	-2213.0	936.0
Rpl29	159.0	619.0
Rpl3	-4501.0	-2250.0
Rpl30	-2227.0	1928.0
Rpl32	-3761.0	-2351.0
Rpl34	-3543.0	30.0
Rpl35	487.0	1260.0
Rpl36al	2480.0	3912.0
Rpl37	-149.0	-1606.0
Rpl37a	-3282.0	3355.0
Rpl38	-2733.0	2650.0
Rpl39	-3209.0	-2749.0
Rpl3l	2793.0	-2167.0
Rpl4	-3278.0	2862.0
Rpl41	-3679.0	-3137.0
Rpl5	-3054.0	4180.0
Rpl6	-2095.0	2537.0
Rpl8	-3311.0	-743.0
Rplp0	-4266.0	2305.0
Rplp1	-2158.0	1851.0
Rplp2	-1425.0	-819.0
Rps11	-3297.0	1463.0
Rps12-ps3	647.0	326.0
Rps13	-2888.0	-1100.0
Rps14	-3976.0	1790.0
Rps15a	-4073.0	-2021.0
Rps16	-4186.0	3466.0
Rps17	-1328.0	3414.0
Rps18	-3908.0	381.0
Rps19	-3711.0	517.0
Rps20	-4500.0	2735.0
Rps21	-2468.0	-4216.0
Rps23	-3039.0	1482.0
Rps24	-3167.0	1026.0
Rps25	-3017.0	134.0
Rps26	-4180.0	3346.0
Rps27	-3613.0	-3831.0
Rps27a	-3651.0	-1238.0
Rps29	205.0	-4120.0
Rps3	-4112.0	3071.0
Rps3a1	-2034.0	4081.0
Rps4x	-3008.0	3564.0
Rps5	-2212.0	2529.0
Rps6	-3395.0	732.0
Rps7	-3555.0	2643.0
Rps8	-3059.0	3170.0
Rps9	-4080.0	-913.0
Rpsa	-2169.0	2893.0
Uba52	-356.0	-284.0

---

---

REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR

REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR

metric	value
setSize	10
pMANOVA	0.0795
p.adjustMANOVA	0.218
s.dist	0.439
s.ctrl	-0.362
s.AcyKD	-0.248
p.ctrl	0.0477
p.AcyKD	0.175

Top 20 genes

Gene	ctrl	AcyKD
Jag2	-4172	-3543
Adam10	-2771	-3978
Dll4	-3264	-3166
Jag1	-2210	-2526
Rps27a	-3651	-1238
Uba52	-356	-284

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Adam10	-2771	-3978
Adam17	3922	285
Dll4	-3264	-3166
Jag1	-2210	-2526
Jag2	-4172	-3543
Notch2	-4139	2289
Notch3	1394	448
Notch4	-2222	123
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC

REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC

metric	value
setSize	14
pMANOVA	0.0183
p.adjustMANOVA	0.0772
s.dist	0.435
s.ctrl	0.021
s.AcyKD	0.434
p.ctrl	0.892
p.AcyKD	0.0049

Top 20 genes

Gene	ctrl	AcyKD
Sec23a	3804	3389
Canx	2201	4056
Erap1	2161	3863
Sec31a	1815	4452
B2m	530	4145

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
B2m	530	4145
Calr	-4052	2443
Canx	2201	4056
Erap1	2161	3863
Hspa5	-240	4227
Pdia3	-1351	-3849
Sar1b	-462	4213
Sec13	2211	-858
Sec23a	3804	3389
Sec24b	-3900	-1778
Sec24c	1342	-530
Sec24d	-1526	632
Sec31a	1815	4452
Tap2	-2202	3562

---

---

REACTOME_ER_PHAGOSOME_PATHWAY

REACTOME_ER_PHAGOSOME_PATHWAY

metric	value
setSize	48
pMANOVA	1.15e-06
p.adjustMANOVA	2.45e-05
s.dist	0.434
s.ctrl	0.0162
s.AcyKD	0.434
p.ctrl	0.846
p.AcyKD	2.04e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Sec61g	2705	3681
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
B2m	530	4145
Psmd6	691	1839

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
B2m	530	4145
Calr	-4052	2443
Pdia3	-1351	-3849
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Sec61a1	-3252	2881
Sec61a2	-694	566
Sec61b	-4240	-3507
Sec61g	2705	3681
Tap2	-2202	3562
Uba52	-356	-284

---

---

REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

metric	value
setSize	10
pMANOVA	0.0581
p.adjustMANOVA	0.174
s.dist	0.42
s.ctrl	0.0718
s.AcyKD	-0.414
p.ctrl	0.694
p.AcyKD	0.0234

Top 20 genes

Gene	ctrl	AcyKD
Kcnc1	4395	-3032
Kcnq4	3348	-3595
Kcnq5	3165	-3220
Kcna7	3750	-2531

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Kcna7	3750	-2531
Kcnab1	1038	4442
Kcnb1	-1462	-780
Kcnc1	4395	-3032
Kcnc3	-3173	-3655
Kcnc4	-4097	-1333
Kcnf1	-1928	-2273
Kcng4	-2450	-3293
Kcnq4	3348	-3595
Kcnq5	3165	-3220

---

---

REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING

REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING

metric	value
setSize	16
pMANOVA	0.0264
p.adjustMANOVA	0.0965
s.dist	0.418
s.ctrl	-0.3
s.AcyKD	-0.291
p.ctrl	0.0379
p.AcyKD	0.0439

Top 20 genes

Gene	ctrl	AcyKD
Rapgef3	-3485	-4588
Vwf	-4479	-2240
Rasgrp2	-3656	-2307
Grb2	-4000	-1530
Akt1	-3249	-1623
Bcar1	-1320	-3150
Ptk2	-1191	-2585
Rap1a	-3378	-111

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Akt1	-3249	-1623
Bcar1	-1320	-3150
Crk	930	-2648
Fn1	1034	-3089
Grb2	-4000	-1530
Pdpk1	2402	-134
Ptk2	-1191	-2585
Ptpn1	-2205	2901
Rap1a	-3378	-111
Rap1b	-3137	781
Rapgef3	-3485	-4588
Rasgrp2	-3656	-2307
Shc1	-1987	2990
Sos1	1741	-2484
Tln1	2615	-1901
Vwf	-4479	-2240

---

---

REACTOME_PEROXISOMAL_LIPID_METABOLISM

REACTOME_PEROXISOMAL_LIPID_METABOLISM

metric	value
setSize	16
pMANOVA	0.0254
p.adjustMANOVA	0.0944
s.dist	0.417
s.ctrl	0.348
s.AcyKD	0.23
p.ctrl	0.016
p.AcyKD	0.111

Top 20 genes

Gene	ctrl	AcyKD
Scp2	4289	4377
Idh1	4055	3456
Hsd17b4	2692	4258
Hacl1	3957	2719
Abcd1	2049	2703
Agps	1899	1773
Amacr	1471	1941

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Abcd1	2049	2703
Acot8	-1876	1050
Acox1	3519	-989
Acox3	-1508	2303
Agps	1899	1773
Amacr	1471	1941
Crat	3472	-596
Crot	-2534	3727
Far1	-4567	-3610
Gnpat	3017	-2778
Hacl1	3957	2719
Hsd17b4	2692	4258
Idh1	4055	3456
Phyh	4259	-170
Scp2	4289	4377
Slc25a17	374	-3329

---

---

REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX

REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX

metric	value
setSize	48
pMANOVA	5.41e-06
p.adjustMANOVA	7.03e-05
s.dist	0.412
s.ctrl	0.0347
s.AcyKD	0.41
p.ctrl	0.678
p.AcyKD	8.93e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Gmnn	2971	2800
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Orc5	2179	2138
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
E2f3	-4344	-4195
Gmnn	2971	2800
Mcm2	-1837	1994
Mcm7	174	995
Orc2	-3240	-511
Orc3	-1914	-607
Orc4	-2456	2113
Orc5	2179	2138
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21

REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21

metric	value
setSize	43
pMANOVA	3.02e-05
p.adjustMANOVA	0.000322
s.dist	0.41
s.ctrl	0.0819
s.AcyKD	0.402
p.ctrl	0.353
p.AcyKD	5.22e-06

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psmd6	691	1839
Psmc2	11	2258

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Ccne2	3265	-3757
Cdkn1a	-2185	3385
Cdkn1b	2606	-2570
Cul1	-2709	1047
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psmf1	-3284	-775
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_ORC1_REMOVAL_FROM_CHROMATIN

REACTOME_ORC1_REMOVAL_FROM_CHROMATIN

metric	value
setSize	49
pMANOVA	6.08e-06
p.adjustMANOVA	7.49e-05
s.dist	0.408
s.ctrl	0.0513
s.AcyKD	0.405
p.ctrl	0.535
p.AcyKD	9.6e-07

Top 20 genes

Gene	ctrl	AcyKD
Psmb3	4044	3313
Psmd2	2475	4489
Psma1	2177	4428
Psmb7	2308	3677
Psmc1	1856	4481
Psmd1	1607	4505
Psma3	2410	2500
Psmd12	2222	2585
Psmb2	1763	3102
Psmc3	1341	3942
Orc5	2179	2138
Psma6	1940	1933
Psmd14	3052	1210
Psmd11	1081	2989
Psmd7	722	3575
Psmb6	749	3233
Psma7	1933	1159
Psme4	502	4407
Psmd6	691	1839
Mcm7	174	995

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Cdkn1a	-2185	3385
Cdkn1b	2606	-2570
Mcm2	-1837	1994
Mcm7	174	995
Orc2	-3240	-511
Orc3	-1914	-607
Orc4	-2456	2113
Orc5	2179	2138
Psma1	2177	4428
Psma2	2294	-1431
Psma3	2410	2500
Psma4	-357	2618
Psma5	-950	3527
Psma6	1940	1933
Psma7	1933	1159
Psmb1	-1343	1177
Psmb10	2346	-822
Psmb2	1763	3102
Psmb3	4044	3313
Psmb4	-2020	31
Psmb5	-749	2676
Psmb6	749	3233
Psmb7	2308	3677
Psmc1	1856	4481
Psmc2	11	2258
Psmc3	1341	3942
Psmc4	-486	3560
Psmc5	-3313	2558
Psmc6	-715	2459
Psmd1	1607	4505
Psmd10	-2548	2666
Psmd11	1081	2989
Psmd12	2222	2585
Psmd13	-499	3161
Psmd14	3052	1210
Psmd2	2475	4489
Psmd3	-1899	925
Psmd4	-1204	2604
Psmd5	-15	1421
Psmd6	691	1839
Psmd7	722	3575
Psmd8	-3451	-619
Psmd9	-550	4520
Psme1	2473	-2877
Psme4	502	4407
Psmf1	-3284	-775
Rb1	2037	-1551
Rps27a	-3651	-1238
Uba52	-356	-284

---

---

REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

metric	value
setSize	20
pMANOVA	0.014
p.adjustMANOVA	0.0623
s.dist	0.404
s.ctrl	-0.315
s.AcyKD	-0.254
p.ctrl	0.0148
p.AcyKD	0.0496

Top 20 genes

Gene	ctrl	AcyKD
Tgif1	-4387	-4174
Hdac1	-4289	-4026
Junb	-3372	-4567
Wwtr1	-3841	-3303
Cdk9	-2500	-2738
Smad7	-2108	-3026
Cdk8	-4122	-1369
E2f4	-1588	-2860
Rps27a	-3651	-1238
Smad4	-1111	-655
Uba52	-356	-284

Click HERE to show all gene set members

All member genes

	ctrl	AcyKD
Bmyc	-3321	2108
Ccnc	898	1380
Ccnt1	1172	1075
Ccnt2	2323	-267
Cdk8	-4122	-1369
Cdk9	-2500	-2738
E2f4	-1588	-2860
Hdac1	-4289	-4026
Junb	-3372	-4567
Men1	-4554	273
Rps27a	-3651	-1238
Smad2	1256	-4237
Smad3	1444	-1044
Smad4	-1111	-655
Smad7	-2108	-3026
Sp1	2643	4148
Tfdp1	-1115	1115
Tgif1	-4387	-4174
Uba52	-356	-284
Wwtr1	-3841	-3303

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report