Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-09-07
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## ctrl Acss2KD
## 0610009B22Rik -0.5488684 -0.3845554
## 0610009L18Rik 0.7010761 0.7909020
## 0610010K14Rik -0.2062781 0.5031172
## 0610012G03Rik -1.0685616 -0.5693632
## 0610030E20Rik 1.0067021 1.1957467
## 0610040J01Rik -0.6151338 -1.1105356| Profile metrics | |
|---|---|
| num_genes_in_profile | 9217 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 2740 |
| num_profile_genes_not_in_sets | 6477 |
| profile_pearson_correl | 0.17981 |
| profile_spearman_correl | 0.12982 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 674 |
| num_genesets_excluded | 212 |
| num_genesets_included | 462 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 32 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.ctrl | s.Acss2KD | p.ctrl | p.Acss2KD |
|---|---|---|---|---|---|---|---|---|
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 3.62e-09 | 1.04e-07 | 0.799 | -0.78400 | 0.1550 | 3.23e-09 | 2.42e-01 |
| REACTOME PEPTIDE CHAIN ELONGATION | 66 | 2.57e-26 | 3.95e-24 | 0.741 | 0.71500 | -0.1960 | 9.48e-24 | 5.89e-03 |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 1.30e-05 | 2.87e-04 | 0.722 | -0.67400 | 0.2610 | 2.61e-05 | 1.03e-01 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 41 | 7.95e-16 | 3.06e-14 | 0.720 | 0.68600 | -0.2170 | 2.90e-14 | 1.64e-02 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 1.07e-19 | 6.17e-18 | 0.692 | -0.69100 | 0.0419 | 4.36e-20 | 5.79e-01 |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 2.22e-04 | 4.47e-03 | 0.687 | -0.68400 | -0.0687 | 4.14e-05 | 6.81e-01 |
| REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 48 | 1.86e-16 | 8.61e-15 | 0.683 | 0.66000 | -0.1720 | 2.43e-15 | 3.93e-02 |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 85 | 2.90e-28 | 6.70e-26 | 0.680 | 0.66000 | -0.1640 | 7.31e-26 | 9.06e-03 |
| REACTOME SIGNALING BY HIPPO | 15 | 8.57e-05 | 1.80e-03 | 0.659 | -0.14700 | -0.6420 | 3.26e-01 | 1.66e-05 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 4.12e-21 | 3.18e-19 | 0.647 | -0.64600 | 0.0254 | 1.29e-21 | 7.09e-01 |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 88 | 1.08e-24 | 1.00e-22 | 0.622 | 0.59900 | -0.1660 | 2.59e-22 | 7.27e-03 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 1.51e-03 | 2.50e-02 | 0.593 | -0.53700 | 0.2520 | 2.04e-03 | 1.48e-01 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 82 | 5.39e-21 | 3.56e-19 | 0.592 | 0.57100 | -0.1590 | 4.29e-19 | 1.30e-02 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 5.12e-26 | 5.91e-24 | 0.591 | -0.58800 | 0.0620 | 8.74e-26 | 2.69e-01 |
| REACTOME TRANSLATION | 123 | 5.64e-30 | 2.60e-27 | 0.586 | 0.57300 | -0.1230 | 6.07e-28 | 1.89e-02 |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 4.25e-03 | 5.78e-02 | 0.548 | 0.51600 | -0.1870 | 3.07e-03 | 2.84e-01 |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 84 | 2.90e-18 | 1.49e-16 | 0.547 | 0.53100 | -0.1280 | 3.98e-17 | 4.23e-02 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 1.00e-07 | 2.44e-06 | 0.512 | -0.49600 | 0.1280 | 1.25e-07 | 1.72e-01 |
| REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | 11 | 1.93e-02 | 1.84e-01 | 0.483 | -0.01570 | 0.4830 | 9.28e-01 | 5.54e-03 |
| REACTOME INFLUENZA LIFE CYCLE | 113 | 6.91e-16 | 2.90e-14 | 0.444 | 0.44000 | -0.0627 | 7.87e-16 | 2.51e-01 |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 11 | 6.21e-02 | 3.19e-01 | 0.436 | 0.27400 | 0.3380 | 1.15e-01 | 5.20e-02 |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 13 | 4.65e-02 | 2.76e-01 | 0.422 | 0.27700 | 0.3180 | 8.38e-02 | 4.74e-02 |
| REACTOME EXTENSION OF TELOMERES | 13 | 2.06e-02 | 1.86e-01 | 0.418 | 0.34800 | -0.2320 | 2.98e-02 | 1.48e-01 |
| REACTOME PYRUVATE METABOLISM | 16 | 9.30e-03 | 1.16e-01 | 0.415 | -0.35700 | 0.2120 | 1.34e-02 | 1.43e-01 |
| REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | 13 | 2.41e-02 | 1.97e-01 | 0.410 | 0.34200 | -0.2260 | 3.29e-02 | 1.58e-01 |
| REACTOME SHC MEDIATED SIGNALLING | 13 | 2.44e-02 | 1.97e-01 | 0.409 | 0.33700 | -0.2320 | 3.57e-02 | 1.47e-01 |
| REACTOME O LINKED GLYCOSYLATION OF MUCINS | 10 | 1.16e-01 | 4.24e-01 | 0.402 | -0.32000 | -0.2440 | 8.02e-02 | 1.81e-01 |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 15 | 2.00e-02 | 1.84e-01 | 0.392 | 0.19900 | -0.3380 | 1.82e-01 | 2.35e-02 |
| REACTOME METABOLISM OF POLYAMINES | 12 | 8.10e-02 | 3.63e-01 | 0.391 | 0.35400 | 0.1640 | 3.36e-02 | 3.25e-01 |
| REACTOME DNA STRAND ELONGATION | 12 | 7.04e-02 | 3.36e-01 | 0.390 | 0.38400 | 0.0721 | 2.15e-02 | 6.66e-01 |
| REACTOME PHOSPHORYLATION OF THE APC C | 14 | 3.58e-02 | 2.39e-01 | 0.377 | 0.15900 | -0.3410 | 3.03e-01 | 2.70e-02 |
| REACTOME CTNNB1 PHOSPHORYLATION CASCADE | 14 | 7.17e-02 | 3.37e-01 | 0.377 | -0.28100 | -0.2510 | 6.86e-02 | 1.05e-01 |
| REACTOME COLLAGEN FORMATION | 26 | 2.68e-03 | 3.95e-02 | 0.374 | -0.10600 | 0.3580 | 3.48e-01 | 1.57e-03 |
| REACTOME HS GAG DEGRADATION | 10 | 9.05e-02 | 3.77e-01 | 0.374 | -0.27300 | 0.2550 | 1.36e-01 | 1.62e-01 |
| REACTOME METAL ION SLC TRANSPORTERS | 12 | 8.20e-02 | 3.64e-01 | 0.371 | 0.00587 | 0.3710 | 9.72e-01 | 2.63e-02 |
| REACTOME SHC1 EVENTS IN EGFR SIGNALING | 14 | 3.84e-02 | 2.47e-01 | 0.369 | 0.21400 | -0.3000 | 1.65e-01 | 5.18e-02 |
| REACTOME SHC RELATED EVENTS | 14 | 4.10e-02 | 2.55e-01 | 0.369 | 0.33200 | -0.1610 | 3.17e-02 | 2.98e-01 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 13 | 5.17e-02 | 2.95e-01 | 0.366 | -0.19100 | 0.3130 | 2.34e-01 | 5.11e-02 |
| REACTOME PLATELET SENSITIZATION BY LDL | 11 | 1.43e-01 | 4.58e-01 | 0.365 | -0.25500 | -0.2610 | 1.43e-01 | 1.34e-01 |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 15 | 7.39e-02 | 3.37e-01 | 0.360 | -0.20800 | -0.2940 | 1.63e-01 | 4.87e-02 |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 17 | 2.42e-02 | 1.97e-01 | 0.357 | 0.22200 | -0.2800 | 1.13e-01 | 4.58e-02 |
| REACTOME MRNA SPLICING | 98 | 9.57e-09 | 2.60e-07 | 0.356 | 0.35500 | 0.0247 | 1.31e-09 | 6.73e-01 |
| REACTOME NCAM1 INTERACTIONS | 16 | 3.93e-02 | 2.49e-01 | 0.346 | -0.16200 | 0.3060 | 2.61e-01 | 3.42e-02 |
| REACTOME TRAFFICKING OF AMPA RECEPTORS | 16 | 7.03e-02 | 3.36e-01 | 0.345 | -0.12400 | -0.3220 | 3.92e-01 | 2.56e-02 |
| REACTOME SIGNALLING TO P38 VIA RIT AND RIN | 11 | 1.13e-01 | 4.24e-01 | 0.344 | 0.13700 | -0.3160 | 4.33e-01 | 6.96e-02 |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 21 | 1.74e-02 | 1.75e-01 | 0.341 | 0.31800 | -0.1240 | 1.17e-02 | 3.27e-01 |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 24 | 1.33e-02 | 1.50e-01 | 0.341 | -0.02280 | 0.3400 | 8.47e-01 | 3.93e-03 |
| REACTOME INSULIN RECEPTOR RECYCLING | 15 | 9.80e-02 | 3.94e-01 | 0.339 | 0.17400 | 0.2910 | 2.44e-01 | 5.12e-02 |
| REACTOME GLUCONEOGENESIS | 19 | 5.03e-02 | 2.90e-01 | 0.337 | -0.12700 | -0.3120 | 3.37e-01 | 1.85e-02 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 16 | 4.50e-02 | 2.70e-01 | 0.337 | 0.18800 | -0.2790 | 1.92e-01 | 5.31e-02 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.ctrl | s.Acss2KD | p.ctrl | p.Acss2KD |
|---|---|---|---|---|---|---|---|---|
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 3.62e-09 | 1.04e-07 | 0.79900 | -0.784000 | 0.155000 | 3.23e-09 | 2.42e-01 |
| REACTOME PEPTIDE CHAIN ELONGATION | 66 | 2.57e-26 | 3.95e-24 | 0.74100 | 0.715000 | -0.196000 | 9.48e-24 | 5.89e-03 |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 1.30e-05 | 2.87e-04 | 0.72200 | -0.674000 | 0.261000 | 2.61e-05 | 1.03e-01 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 41 | 7.95e-16 | 3.06e-14 | 0.72000 | 0.686000 | -0.217000 | 2.90e-14 | 1.64e-02 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 1.07e-19 | 6.17e-18 | 0.69200 | -0.691000 | 0.041900 | 4.36e-20 | 5.79e-01 |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 2.22e-04 | 4.47e-03 | 0.68700 | -0.684000 | -0.068700 | 4.14e-05 | 6.81e-01 |
| REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 48 | 1.86e-16 | 8.61e-15 | 0.68300 | 0.660000 | -0.172000 | 2.43e-15 | 3.93e-02 |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 85 | 2.90e-28 | 6.70e-26 | 0.68000 | 0.660000 | -0.164000 | 7.31e-26 | 9.06e-03 |
| REACTOME SIGNALING BY HIPPO | 15 | 8.57e-05 | 1.80e-03 | 0.65900 | -0.147000 | -0.642000 | 3.26e-01 | 1.66e-05 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 4.12e-21 | 3.18e-19 | 0.64700 | -0.646000 | 0.025400 | 1.29e-21 | 7.09e-01 |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 88 | 1.08e-24 | 1.00e-22 | 0.62200 | 0.599000 | -0.166000 | 2.59e-22 | 7.27e-03 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 1.51e-03 | 2.50e-02 | 0.59300 | -0.537000 | 0.252000 | 2.04e-03 | 1.48e-01 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 82 | 5.39e-21 | 3.56e-19 | 0.59200 | 0.571000 | -0.159000 | 4.29e-19 | 1.30e-02 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 5.12e-26 | 5.91e-24 | 0.59100 | -0.588000 | 0.062000 | 8.74e-26 | 2.69e-01 |
| REACTOME TRANSLATION | 123 | 5.64e-30 | 2.60e-27 | 0.58600 | 0.573000 | -0.123000 | 6.07e-28 | 1.89e-02 |
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 4.25e-03 | 5.78e-02 | 0.54800 | 0.516000 | -0.187000 | 3.07e-03 | 2.84e-01 |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 84 | 2.90e-18 | 1.49e-16 | 0.54700 | 0.531000 | -0.128000 | 3.98e-17 | 4.23e-02 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 1.00e-07 | 2.44e-06 | 0.51200 | -0.496000 | 0.128000 | 1.25e-07 | 1.72e-01 |
| REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | 11 | 1.93e-02 | 1.84e-01 | 0.48300 | -0.015700 | 0.483000 | 9.28e-01 | 5.54e-03 |
| REACTOME INFLUENZA LIFE CYCLE | 113 | 6.91e-16 | 2.90e-14 | 0.44400 | 0.440000 | -0.062700 | 7.87e-16 | 2.51e-01 |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 11 | 6.21e-02 | 3.19e-01 | 0.43600 | 0.274000 | 0.338000 | 1.15e-01 | 5.20e-02 |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 13 | 4.65e-02 | 2.76e-01 | 0.42200 | 0.277000 | 0.318000 | 8.38e-02 | 4.74e-02 |
| REACTOME EXTENSION OF TELOMERES | 13 | 2.06e-02 | 1.86e-01 | 0.41800 | 0.348000 | -0.232000 | 2.98e-02 | 1.48e-01 |
| REACTOME PYRUVATE METABOLISM | 16 | 9.30e-03 | 1.16e-01 | 0.41500 | -0.357000 | 0.212000 | 1.34e-02 | 1.43e-01 |
| REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | 13 | 2.41e-02 | 1.97e-01 | 0.41000 | 0.342000 | -0.226000 | 3.29e-02 | 1.58e-01 |
| REACTOME SHC MEDIATED SIGNALLING | 13 | 2.44e-02 | 1.97e-01 | 0.40900 | 0.337000 | -0.232000 | 3.57e-02 | 1.47e-01 |
| REACTOME O LINKED GLYCOSYLATION OF MUCINS | 10 | 1.16e-01 | 4.24e-01 | 0.40200 | -0.320000 | -0.244000 | 8.02e-02 | 1.81e-01 |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 15 | 2.00e-02 | 1.84e-01 | 0.39200 | 0.199000 | -0.338000 | 1.82e-01 | 2.35e-02 |
| REACTOME METABOLISM OF POLYAMINES | 12 | 8.10e-02 | 3.63e-01 | 0.39100 | 0.354000 | 0.164000 | 3.36e-02 | 3.25e-01 |
| REACTOME DNA STRAND ELONGATION | 12 | 7.04e-02 | 3.36e-01 | 0.39000 | 0.384000 | 0.072100 | 2.15e-02 | 6.66e-01 |
| REACTOME PHOSPHORYLATION OF THE APC C | 14 | 3.58e-02 | 2.39e-01 | 0.37700 | 0.159000 | -0.341000 | 3.03e-01 | 2.70e-02 |
| REACTOME CTNNB1 PHOSPHORYLATION CASCADE | 14 | 7.17e-02 | 3.37e-01 | 0.37700 | -0.281000 | -0.251000 | 6.86e-02 | 1.05e-01 |
| REACTOME COLLAGEN FORMATION | 26 | 2.68e-03 | 3.95e-02 | 0.37400 | -0.106000 | 0.358000 | 3.48e-01 | 1.57e-03 |
| REACTOME HS GAG DEGRADATION | 10 | 9.05e-02 | 3.77e-01 | 0.37400 | -0.273000 | 0.255000 | 1.36e-01 | 1.62e-01 |
| REACTOME METAL ION SLC TRANSPORTERS | 12 | 8.20e-02 | 3.64e-01 | 0.37100 | 0.005870 | 0.371000 | 9.72e-01 | 2.63e-02 |
| REACTOME SHC1 EVENTS IN EGFR SIGNALING | 14 | 3.84e-02 | 2.47e-01 | 0.36900 | 0.214000 | -0.300000 | 1.65e-01 | 5.18e-02 |
| REACTOME SHC RELATED EVENTS | 14 | 4.10e-02 | 2.55e-01 | 0.36900 | 0.332000 | -0.161000 | 3.17e-02 | 2.98e-01 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 13 | 5.17e-02 | 2.95e-01 | 0.36600 | -0.191000 | 0.313000 | 2.34e-01 | 5.11e-02 |
| REACTOME PLATELET SENSITIZATION BY LDL | 11 | 1.43e-01 | 4.58e-01 | 0.36500 | -0.255000 | -0.261000 | 1.43e-01 | 1.34e-01 |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 15 | 7.39e-02 | 3.37e-01 | 0.36000 | -0.208000 | -0.294000 | 1.63e-01 | 4.87e-02 |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 17 | 2.42e-02 | 1.97e-01 | 0.35700 | 0.222000 | -0.280000 | 1.13e-01 | 4.58e-02 |
| REACTOME MRNA SPLICING | 98 | 9.57e-09 | 2.60e-07 | 0.35600 | 0.355000 | 0.024700 | 1.31e-09 | 6.73e-01 |
| REACTOME NCAM1 INTERACTIONS | 16 | 3.93e-02 | 2.49e-01 | 0.34600 | -0.162000 | 0.306000 | 2.61e-01 | 3.42e-02 |
| REACTOME TRAFFICKING OF AMPA RECEPTORS | 16 | 7.03e-02 | 3.36e-01 | 0.34500 | -0.124000 | -0.322000 | 3.92e-01 | 2.56e-02 |
| REACTOME SIGNALLING TO P38 VIA RIT AND RIN | 11 | 1.13e-01 | 4.24e-01 | 0.34400 | 0.137000 | -0.316000 | 4.33e-01 | 6.96e-02 |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 21 | 1.74e-02 | 1.75e-01 | 0.34100 | 0.318000 | -0.124000 | 1.17e-02 | 3.27e-01 |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 24 | 1.33e-02 | 1.50e-01 | 0.34100 | -0.022800 | 0.340000 | 8.47e-01 | 3.93e-03 |
| REACTOME INSULIN RECEPTOR RECYCLING | 15 | 9.80e-02 | 3.94e-01 | 0.33900 | 0.174000 | 0.291000 | 2.44e-01 | 5.12e-02 |
| REACTOME GLUCONEOGENESIS | 19 | 5.03e-02 | 2.90e-01 | 0.33700 | -0.127000 | -0.312000 | 3.37e-01 | 1.85e-02 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 16 | 4.50e-02 | 2.70e-01 | 0.33700 | 0.188000 | -0.279000 | 1.92e-01 | 5.31e-02 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | 16 | 9.00e-02 | 3.77e-01 | 0.33600 | -0.267000 | -0.204000 | 6.46e-02 | 1.57e-01 |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 24 | 1.05e-02 | 1.28e-01 | 0.33600 | -0.297000 | 0.155000 | 1.17e-02 | 1.88e-01 |
| REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 15 | 5.75e-02 | 3.12e-01 | 0.33300 | 0.215000 | -0.254000 | 1.50e-01 | 8.85e-02 |
| REACTOME PURINE SALVAGE | 10 | 2.31e-01 | 5.88e-01 | 0.33200 | -0.205000 | -0.261000 | 2.63e-01 | 1.53e-01 |
| REACTOME CYTOSOLIC TRNA AMINOACYLATION | 22 | 3.03e-02 | 2.33e-01 | 0.32900 | 0.326000 | 0.048100 | 8.18e-03 | 6.96e-01 |
| REACTOME MRNA 3 END PROCESSING | 30 | 1.37e-02 | 1.50e-01 | 0.32800 | 0.260000 | 0.201000 | 1.39e-02 | 5.75e-02 |
| REACTOME MITOCHONDRIAL PROTEIN IMPORT | 42 | 1.25e-03 | 2.14e-02 | 0.32400 | -0.324000 | 0.001300 | 2.90e-04 | 9.88e-01 |
| REACTOME MRNA SPLICING MINOR PATHWAY | 38 | 1.88e-03 | 2.99e-02 | 0.32300 | 0.319000 | -0.050900 | 6.70e-04 | 5.88e-01 |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | 11 | 1.52e-01 | 4.65e-01 | 0.31900 | 0.283000 | -0.147000 | 1.04e-01 | 4.00e-01 |
| REACTOME STRIATED MUSCLE CONTRACTION | 22 | 3.33e-02 | 2.39e-01 | 0.31500 | -0.032100 | 0.313000 | 7.95e-01 | 1.11e-02 |
| REACTOME HS GAG BIOSYNTHESIS | 15 | 1.09e-01 | 4.24e-01 | 0.31400 | -0.313000 | -0.018100 | 3.57e-02 | 9.03e-01 |
| REACTOME TELOMERE MAINTENANCE | 17 | 5.85e-02 | 3.12e-01 | 0.31200 | 0.236000 | -0.204000 | 9.24e-02 | 1.46e-01 |
| REACTOME SOS MEDIATED SIGNALLING | 13 | 1.20e-01 | 4.24e-01 | 0.31100 | 0.151000 | -0.272000 | 3.46e-01 | 9.00e-02 |
| REACTOME INTERFERON GAMMA SIGNALING | 21 | 3.38e-02 | 2.39e-01 | 0.31000 | 0.142000 | -0.275000 | 2.61e-01 | 2.92e-02 |
| REACTOME IRON UPTAKE AND TRANSPORT | 23 | 5.38e-02 | 3.03e-01 | 0.30700 | 0.154000 | 0.265000 | 2.01e-01 | 2.77e-02 |
| REACTOME MYOGENESIS | 21 | 7.22e-02 | 3.37e-01 | 0.30600 | -0.250000 | -0.176000 | 4.74e-02 | 1.62e-01 |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 124 | 6.82e-08 | 1.75e-06 | 0.30500 | 0.299000 | 0.060500 | 1.01e-08 | 2.46e-01 |
| REACTOME BOTULINUM NEUROTOXICITY | 10 | 2.24e-01 | 5.74e-01 | 0.30200 | -0.097900 | 0.285000 | 5.92e-01 | 1.18e-01 |
| REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | 10 | 2.24e-01 | 5.74e-01 | 0.30200 | -0.097900 | 0.285000 | 5.92e-01 | 1.18e-01 |
| REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | 17 | 1.31e-01 | 4.41e-01 | 0.30000 | 0.177000 | 0.242000 | 2.06e-01 | 8.48e-02 |
| REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | 14 | 1.17e-01 | 4.24e-01 | 0.29900 | 0.240000 | -0.178000 | 1.20e-01 | 2.48e-01 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 16 | 1.05e-01 | 4.19e-01 | 0.29800 | -0.294000 | 0.048100 | 4.19e-02 | 7.39e-01 |
| REACTOME CELL JUNCTION ORGANIZATION | 30 | 2.60e-02 | 2.07e-01 | 0.29600 | -0.276000 | -0.109000 | 9.04e-03 | 3.04e-01 |
| REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 41 | 2.73e-03 | 3.95e-02 | 0.29600 | -0.280000 | 0.097400 | 1.97e-03 | 2.81e-01 |
| REACTOME METABOLISM OF MRNA | 176 | 3.79e-11 | 1.25e-09 | 0.29200 | 0.280000 | -0.080000 | 1.67e-10 | 6.87e-02 |
| REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | 22 | 8.64e-02 | 3.73e-01 | 0.29000 | -0.213000 | -0.196000 | 8.35e-02 | 1.11e-01 |
| REACTOME EXTRACELLULAR MATRIX ORGANIZATION | 31 | 1.36e-02 | 1.50e-01 | 0.28700 | -0.132000 | 0.255000 | 2.04e-01 | 1.41e-02 |
| REACTOME MTORC1 MEDIATED SIGNALLING | 11 | 2.82e-01 | 6.52e-01 | 0.28600 | 0.272000 | 0.086500 | 1.18e-01 | 6.19e-01 |
| REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | 12 | 2.60e-01 | 6.22e-01 | 0.28600 | -0.261000 | -0.116000 | 1.17e-01 | 4.88e-01 |
| REACTOME RNA POL III CHAIN ELONGATION | 16 | 1.10e-01 | 4.24e-01 | 0.28500 | 0.146000 | -0.245000 | 3.13e-01 | 8.99e-02 |
| REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | 12 | 2.07e-01 | 5.56e-01 | 0.28400 | -0.275000 | 0.073900 | 9.97e-02 | 6.58e-01 |
| REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | 48 | 5.94e-03 | 7.75e-02 | 0.28400 | 0.209000 | 0.193000 | 1.24e-02 | 2.11e-02 |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | 16 | 1.17e-01 | 4.24e-01 | 0.28400 | 0.261000 | -0.112000 | 7.13e-02 | 4.39e-01 |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 13 | 1.88e-01 | 5.38e-01 | 0.28200 | 0.274000 | -0.066900 | 8.69e-02 | 6.76e-01 |
| REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 21 | 6.88e-02 | 3.34e-01 | 0.28000 | -0.080800 | 0.268000 | 5.22e-01 | 3.39e-02 |
| REACTOME BASE EXCISION REPAIR | 11 | 2.62e-01 | 6.23e-01 | 0.27900 | 0.278000 | -0.028900 | 1.11e-01 | 8.68e-01 |
| REACTOME GLUCOSE TRANSPORT | 29 | 4.14e-02 | 2.55e-01 | 0.27800 | 0.074200 | 0.268000 | 4.89e-01 | 1.25e-02 |
| REACTOME ACTIVATION OF BH3 ONLY PROTEINS | 11 | 3.04e-01 | 6.82e-01 | 0.27800 | -0.088300 | -0.263000 | 6.12e-01 | 1.31e-01 |
| REACTOME ION CHANNEL TRANSPORT | 18 | 9.50e-02 | 3.88e-01 | 0.27600 | -0.167000 | 0.220000 | 2.20e-01 | 1.06e-01 |
| REACTOME LIPOPROTEIN METABOLISM | 11 | 3.30e-01 | 7.12e-01 | 0.27500 | -0.226000 | -0.156000 | 1.95e-01 | 3.69e-01 |
| REACTOME MRNA PROCESSING | 137 | 7.01e-07 | 1.62e-05 | 0.26900 | 0.264000 | 0.051000 | 1.08e-07 | 3.05e-01 |
| REACTOME SIGNALLING TO RAS | 20 | 8.58e-02 | 3.73e-01 | 0.26700 | 0.207000 | -0.169000 | 1.09e-01 | 1.91e-01 |
| REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | 16 | 1.93e-01 | 5.43e-01 | 0.26700 | -0.261000 | -0.058400 | 7.08e-02 | 6.86e-01 |
| REACTOME CTLA4 INHIBITORY SIGNALING | 15 | 2.35e-01 | 5.88e-01 | 0.26700 | -0.231000 | -0.133000 | 1.21e-01 | 3.72e-01 |
| REACTOME RNA POL III TRANSCRIPTION TERMINATION | 18 | 1.20e-01 | 4.24e-01 | 0.26700 | 0.093900 | -0.250000 | 4.91e-01 | 6.67e-02 |
| REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 14 | 2.17e-01 | 5.68e-01 | 0.26600 | 0.266000 | -0.009110 | 8.48e-02 | 9.53e-01 |
| REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | 35 | 3.57e-02 | 2.39e-01 | 0.26500 | 0.231000 | 0.130000 | 1.80e-02 | 1.83e-01 |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | 10 | 4.04e-01 | 7.55e-01 | 0.26000 | -0.220000 | -0.137000 | 2.28e-01 | 4.52e-01 |
| REACTOME METABOLISM OF RNA | 215 | 1.96e-10 | 6.03e-09 | 0.25700 | 0.252000 | -0.053000 | 2.56e-10 | 1.83e-01 |
| REACTOME CHROMOSOME MAINTENANCE | 34 | 2.21e-02 | 1.96e-01 | 0.25600 | 0.193000 | -0.168000 | 5.16e-02 | 9.12e-02 |
| REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | 20 | 1.38e-01 | 4.55e-01 | 0.25300 | 0.014000 | -0.253000 | 9.14e-01 | 5.04e-02 |
| REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | 18 | 1.37e-01 | 4.55e-01 | 0.25300 | -0.185000 | 0.173000 | 1.75e-01 | 2.04e-01 |
| REACTOME NRAGE SIGNALS DEATH THROUGH JNK | 27 | 6.04e-02 | 3.14e-01 | 0.25100 | -0.235000 | 0.087500 | 3.45e-02 | 4.32e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | 25 | 6.73e-02 | 3.31e-01 | 0.25100 | 0.194000 | -0.159000 | 9.34e-02 | 1.69e-01 |
| REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | 19 | 1.40e-01 | 4.57e-01 | 0.24900 | 0.226000 | -0.103000 | 8.79e-02 | 4.37e-01 |
| REACTOME BASIGIN INTERACTIONS | 13 | 3.51e-01 | 7.15e-01 | 0.24600 | 0.155000 | 0.192000 | 3.34e-01 | 2.32e-01 |
| REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 20 | 2.04e-01 | 5.56e-01 | 0.24500 | -0.162000 | -0.184000 | 2.10e-01 | 1.55e-01 |
| REACTOME G2 M CHECKPOINTS | 17 | 1.85e-01 | 5.37e-01 | 0.24400 | 0.221000 | -0.103000 | 1.15e-01 | 4.62e-01 |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 36 | 5.59e-02 | 3.11e-01 | 0.24300 | 0.214000 | 0.114000 | 2.61e-02 | 2.35e-01 |
| REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | 43 | 2.32e-02 | 1.97e-01 | 0.24100 | 0.241000 | 0.010800 | 6.27e-03 | 9.03e-01 |
| REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 10 | 3.76e-01 | 7.33e-01 | 0.24100 | -0.116000 | 0.211000 | 5.26e-01 | 2.49e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | 21 | 1.25e-01 | 4.31e-01 | 0.24000 | 0.158000 | -0.180000 | 2.09e-01 | 1.53e-01 |
| REACTOME METABOLISM OF PROTEINS | 300 | 9.95e-13 | 3.54e-11 | 0.23900 | 0.223000 | -0.086000 | 4.21e-11 | 1.12e-02 |
| REACTOME IL RECEPTOR SHC SIGNALING | 15 | 2.79e-01 | 6.49e-01 | 0.23900 | 0.238000 | 0.022900 | 1.10e-01 | 8.78e-01 |
| REACTOME GPCR LIGAND BINDING | 38 | 4.83e-02 | 2.82e-01 | 0.23900 | -0.226000 | -0.076900 | 1.60e-02 | 4.13e-01 |
| REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | 17 | 2.68e-01 | 6.32e-01 | 0.23800 | -0.109000 | -0.212000 | 4.37e-01 | 1.30e-01 |
| REACTOME GLOBAL GENOMIC NER GG NER | 23 | 1.50e-01 | 4.63e-01 | 0.23800 | 0.234000 | 0.040300 | 5.17e-02 | 7.38e-01 |
| REACTOME ION TRANSPORT BY P TYPE ATPASES | 17 | 2.04e-01 | 5.56e-01 | 0.23500 | -0.121000 | 0.201000 | 3.86e-01 | 1.52e-01 |
| REACTOME PHASE II CONJUGATION | 24 | 1.76e-01 | 5.22e-01 | 0.23400 | 0.163000 | 0.168000 | 1.68e-01 | 1.55e-01 |
| REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 21 | 1.44e-01 | 4.58e-01 | 0.23200 | -0.154000 | 0.174000 | 2.23e-01 | 1.69e-01 |
| REACTOME SULFUR AMINO ACID METABOLISM | 18 | 2.40e-01 | 5.94e-01 | 0.23100 | 0.230000 | 0.024500 | 9.14e-02 | 8.57e-01 |
| REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | 10 | 4.95e-01 | 8.14e-01 | 0.23000 | -0.173000 | -0.151000 | 3.43e-01 | 4.07e-01 |
| REACTOME IL 2 SIGNALING | 25 | 1.16e-01 | 4.24e-01 | 0.22800 | 0.213000 | -0.083000 | 6.61e-02 | 4.73e-01 |
| REACTOME MEMBRANE TRAFFICKING | 92 | 6.79e-04 | 1.25e-02 | 0.22700 | 0.226000 | -0.017300 | 1.84e-04 | 7.75e-01 |
| REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 12 | 3.91e-01 | 7.47e-01 | 0.22600 | -0.008380 | 0.226000 | 9.60e-01 | 1.76e-01 |
| REACTOME P38MAPK EVENTS | 10 | 5.11e-01 | 8.18e-01 | 0.22400 | -0.135000 | -0.179000 | 4.60e-01 | 3.27e-01 |
| REACTOME PROTEIN FOLDING | 40 | 3.48e-02 | 2.39e-01 | 0.22400 | 0.200000 | -0.099500 | 2.85e-02 | 2.77e-01 |
| REACTOME PI3K EVENTS IN ERBB4 SIGNALING | 28 | 1.47e-01 | 4.58e-01 | 0.22300 | 0.091500 | 0.204000 | 4.03e-01 | 6.22e-02 |
| REACTOME TIE2 SIGNALING | 13 | 3.68e-01 | 7.20e-01 | 0.22300 | -0.223000 | 0.012200 | 1.64e-01 | 9.39e-01 |
| REACTOME FATTY ACYL COA BIOSYNTHESIS | 11 | 4.79e-01 | 8.02e-01 | 0.22200 | -0.105000 | -0.195000 | 5.46e-01 | 2.62e-01 |
| REACTOME GPVI MEDIATED ACTIVATION CASCADE | 16 | 2.94e-01 | 6.67e-01 | 0.22100 | -0.021800 | 0.220000 | 8.80e-01 | 1.28e-01 |
| REACTOME SIGNALING BY NOTCH3 | 10 | 5.10e-01 | 8.18e-01 | 0.22100 | -0.090400 | -0.202000 | 6.21e-01 | 2.69e-01 |
| REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | 22 | 2.09e-01 | 5.56e-01 | 0.22000 | 0.218000 | 0.031400 | 7.68e-02 | 7.99e-01 |
| REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 15 | 3.85e-01 | 7.44e-01 | 0.21600 | 0.192000 | 0.099000 | 1.98e-01 | 5.07e-01 |
| REACTOME SIGNALING BY ROBO RECEPTOR | 19 | 3.01e-01 | 6.79e-01 | 0.21600 | -0.105000 | -0.189000 | 4.28e-01 | 1.55e-01 |
| REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 10 | 4.77e-01 | 8.02e-01 | 0.21600 | 0.037500 | -0.212000 | 8.37e-01 | 2.45e-01 |
| REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 23 | 2.04e-01 | 5.56e-01 | 0.21600 | 0.018500 | 0.215000 | 8.78e-01 | 7.47e-02 |
| REACTOME RECYCLING PATHWAY OF L1 | 19 | 2.85e-01 | 6.56e-01 | 0.21400 | 0.044500 | 0.209000 | 7.37e-01 | 1.14e-01 |
| REACTOME MUSCLE CONTRACTION | 36 | 9.50e-02 | 3.88e-01 | 0.21300 | 0.047100 | 0.208000 | 6.25e-01 | 3.08e-02 |
| REACTOME GLYCOSPHINGOLIPID METABOLISM | 20 | 2.71e-01 | 6.32e-01 | 0.21200 | -0.033100 | -0.209000 | 7.98e-01 | 1.06e-01 |
| REACTOME PLATELET HOMEOSTASIS | 32 | 1.47e-01 | 4.58e-01 | 0.21100 | -0.114000 | -0.178000 | 2.64e-01 | 8.18e-02 |
| REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | 11 | 4.45e-01 | 7.87e-01 | 0.20700 | -0.123000 | 0.167000 | 4.79e-01 | 3.38e-01 |
| REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | 15 | 3.31e-01 | 7.12e-01 | 0.20700 | 0.131000 | -0.161000 | 3.80e-01 | 2.82e-01 |
| REACTOME VIRAL MESSENGER RNA SYNTHESIS | 14 | 3.57e-01 | 7.15e-01 | 0.20700 | 0.134000 | -0.158000 | 3.87e-01 | 3.07e-01 |
| REACTOME CELL CELL COMMUNICATION | 54 | 3.47e-02 | 2.39e-01 | 0.20600 | -0.204000 | -0.028900 | 9.52e-03 | 7.14e-01 |
| REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | 11 | 5.41e-01 | 8.33e-01 | 0.20500 | 0.134000 | 0.155000 | 4.40e-01 | 3.74e-01 |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | 33 | 1.59e-01 | 4.82e-01 | 0.20500 | -0.162000 | -0.125000 | 1.07e-01 | 2.15e-01 |
| REACTOME SEMAPHORIN INTERACTIONS | 42 | 7.44e-02 | 3.37e-01 | 0.20500 | -0.203000 | -0.020900 | 2.27e-02 | 8.15e-01 |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 47 | 3.50e-02 | 2.39e-01 | 0.20400 | -0.157000 | 0.130000 | 6.26e-02 | 1.23e-01 |
| REACTOME TCR SIGNALING | 28 | 2.09e-01 | 5.56e-01 | 0.20300 | -0.178000 | -0.097500 | 1.03e-01 | 3.72e-01 |
| REACTOME NEPHRIN INTERACTIONS | 15 | 3.58e-01 | 7.15e-01 | 0.20300 | -0.078000 | 0.187000 | 6.01e-01 | 2.09e-01 |
| REACTOME GLYCOLYSIS | 19 | 2.66e-01 | 6.30e-01 | 0.20300 | 0.103000 | -0.175000 | 4.39e-01 | 1.87e-01 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 57 | 1.93e-02 | 1.84e-01 | 0.20100 | 0.149000 | -0.135000 | 5.22e-02 | 7.84e-02 |
| REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | 10 | 5.34e-01 | 8.33e-01 | 0.20100 | 0.015300 | -0.200000 | 9.33e-01 | 2.73e-01 |
| REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | 18 | 2.94e-01 | 6.67e-01 | 0.20100 | -0.097700 | 0.175000 | 4.73e-01 | 1.99e-01 |
| REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | 22 | 3.14e-01 | 6.83e-01 | 0.19900 | -0.122000 | -0.157000 | 3.21e-01 | 2.02e-01 |
| REACTOME G ALPHA1213 SIGNALLING EVENTS | 42 | 6.03e-02 | 3.14e-01 | 0.19800 | -0.162000 | 0.114000 | 6.98e-02 | 2.01e-01 |
| REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 17 | 4.00e-01 | 7.55e-01 | 0.19700 | 0.069200 | 0.184000 | 6.22e-01 | 1.89e-01 |
| REACTOME RNA POL III TRANSCRIPTION | 31 | 1.29e-01 | 4.40e-01 | 0.19600 | 0.138000 | -0.139000 | 1.83e-01 | 1.80e-01 |
| REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | 49 | 5.73e-02 | 3.12e-01 | 0.19500 | 0.195000 | -0.006270 | 1.83e-02 | 9.40e-01 |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 54 | 4.38e-02 | 2.66e-01 | 0.19500 | 0.195000 | -0.002040 | 1.32e-02 | 9.79e-01 |
| REACTOME PERK REGULATED GENE EXPRESSION | 22 | 2.71e-01 | 6.32e-01 | 0.19500 | -0.020100 | 0.194000 | 8.71e-01 | 1.16e-01 |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 61 | 1.95e-02 | 1.84e-01 | 0.19500 | 0.161000 | -0.110000 | 3.01e-02 | 1.38e-01 |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 54 | 3.22e-02 | 2.39e-01 | 0.19300 | 0.142000 | -0.130000 | 7.06e-02 | 9.95e-02 |
| REACTOME ACTIVATION OF GENES BY ATF4 | 19 | 3.40e-01 | 7.15e-01 | 0.19200 | -0.011400 | 0.191000 | 9.32e-01 | 1.49e-01 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | 12 | 5.29e-01 | 8.32e-01 | 0.19100 | -0.034300 | -0.188000 | 8.37e-01 | 2.60e-01 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 11 | 5.12e-01 | 8.18e-01 | 0.19100 | -0.173000 | 0.080600 | 3.21e-01 | 6.43e-01 |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 21 | 3.56e-01 | 7.15e-01 | 0.18900 | 0.172000 | 0.080100 | 1.73e-01 | 5.26e-01 |
| REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | 16 | 4.56e-01 | 7.89e-01 | 0.18900 | 0.077700 | 0.172000 | 5.91e-01 | 2.33e-01 |
| REACTOME GPCR DOWNSTREAM SIGNALING | 103 | 2.19e-03 | 3.38e-02 | 0.18700 | -0.144000 | 0.119000 | 1.20e-02 | 3.69e-02 |
| REACTOME DARPP 32 EVENTS | 17 | 3.61e-01 | 7.15e-01 | 0.18700 | 0.133000 | -0.131000 | 3.41e-01 | 3.52e-01 |
| REACTOME DNA REPAIR | 65 | 3.62e-02 | 2.39e-01 | 0.18600 | 0.185000 | 0.022300 | 9.98e-03 | 7.57e-01 |
| REACTOME PRE NOTCH PROCESSING IN GOLGI | 14 | 4.37e-01 | 7.80e-01 | 0.18600 | -0.142000 | 0.119000 | 3.57e-01 | 4.39e-01 |
| REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | 18 | 4.03e-01 | 7.55e-01 | 0.18500 | 0.025700 | 0.184000 | 8.51e-01 | 1.78e-01 |
| REACTOME FRS2 MEDIATED CASCADE | 16 | 3.90e-01 | 7.47e-01 | 0.18500 | 0.143000 | -0.118000 | 3.23e-01 | 4.14e-01 |
| REACTOME NETRIN1 SIGNALING | 21 | 3.44e-01 | 7.15e-01 | 0.18300 | -0.183000 | -0.005220 | 1.46e-01 | 9.67e-01 |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 57 | 3.79e-02 | 2.46e-01 | 0.18300 | 0.122000 | -0.137000 | 1.12e-01 | 7.48e-02 |
| REACTOME TRNA AMINOACYLATION | 39 | 1.13e-01 | 4.24e-01 | 0.18300 | 0.166000 | -0.077300 | 7.34e-02 | 4.04e-01 |
| REACTOME CELL CYCLE CHECKPOINTS | 78 | 1.20e-02 | 1.42e-01 | 0.18300 | 0.150000 | -0.105000 | 2.26e-02 | 1.10e-01 |
| REACTOME DEADENYLATION OF MRNA | 16 | 4.00e-01 | 7.55e-01 | 0.18300 | 0.134000 | -0.124000 | 3.53e-01 | 3.92e-01 |
| REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | 15 | 4.47e-01 | 7.87e-01 | 0.18200 | -0.050900 | 0.174000 | 7.33e-01 | 2.43e-01 |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 127 | 1.10e-03 | 1.95e-02 | 0.17900 | -0.150000 | 0.097500 | 3.75e-03 | 5.87e-02 |
| REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | 18 | 3.79e-01 | 7.37e-01 | 0.17800 | -0.156000 | 0.087400 | 2.53e-01 | 5.21e-01 |
| REACTOME BIOLOGICAL OXIDATIONS | 39 | 1.85e-01 | 5.37e-01 | 0.17800 | 0.077100 | 0.161000 | 4.05e-01 | 8.31e-02 |
| REACTOME INWARDLY RECTIFYING K CHANNELS | 10 | 6.54e-01 | 9.06e-01 | 0.17800 | -0.096500 | -0.149000 | 5.97e-01 | 4.14e-01 |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | 19 | 3.61e-01 | 7.15e-01 | 0.17800 | 0.092500 | -0.152000 | 4.86e-01 | 2.52e-01 |
| REACTOME SIGNALING BY RHO GTPASES | 62 | 7.33e-02 | 3.37e-01 | 0.17700 | -0.156000 | -0.083200 | 3.42e-02 | 2.58e-01 |
| REACTOME SIGNALING BY BMP | 17 | 4.05e-01 | 7.55e-01 | 0.17600 | -0.141000 | 0.106000 | 3.16e-01 | 4.50e-01 |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 43 | 1.06e-01 | 4.20e-01 | 0.17600 | -0.152000 | 0.088800 | 8.60e-02 | 3.14e-01 |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 81 | 1.51e-02 | 1.62e-01 | 0.17400 | -0.120000 | 0.126000 | 6.32e-02 | 4.98e-02 |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | 16 | 4.37e-01 | 7.80e-01 | 0.17400 | 0.099800 | -0.143000 | 4.90e-01 | 3.24e-01 |
| REACTOME SIGNALING BY NOTCH2 | 10 | 6.61e-01 | 9.06e-01 | 0.17400 | -0.075400 | -0.157000 | 6.80e-01 | 3.91e-01 |
| REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | 19 | 4.68e-01 | 7.98e-01 | 0.17300 | 0.139000 | 0.104000 | 2.96e-01 | 4.34e-01 |
| REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | 22 | 3.60e-01 | 7.15e-01 | 0.17300 | 0.172000 | -0.015300 | 1.63e-01 | 9.01e-01 |
| REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | 10 | 5.99e-01 | 8.73e-01 | 0.17300 | -0.125000 | 0.119000 | 4.93e-01 | 5.16e-01 |
| REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | 24 | 3.64e-01 | 7.15e-01 | 0.17200 | 0.045800 | 0.166000 | 6.98e-01 | 1.59e-01 |
| REACTOME SIGNAL ATTENUATION | 10 | 6.75e-01 | 9.06e-01 | 0.17200 | 0.121000 | 0.123000 | 5.08e-01 | 5.02e-01 |
| REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | 13 | 5.33e-01 | 8.33e-01 | 0.16900 | -0.150000 | 0.079500 | 3.50e-01 | 6.20e-01 |
| REACTOME TRANSCRIPTION | 124 | 6.04e-03 | 7.75e-02 | 0.16900 | 0.167000 | 0.030100 | 1.41e-03 | 5.65e-01 |
| REACTOME INTERFERON ALPHA BETA SIGNALING | 14 | 5.72e-01 | 8.47e-01 | 0.16900 | -0.054100 | -0.160000 | 7.26e-01 | 3.01e-01 |
| REACTOME ER PHAGOSOME PATHWAY | 49 | 9.79e-02 | 3.94e-01 | 0.16900 | 0.152000 | -0.072300 | 6.57e-02 | 3.82e-01 |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 11 | 6.50e-01 | 9.06e-01 | 0.16700 | -0.158000 | -0.054800 | 3.65e-01 | 7.53e-01 |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 43 | 1.43e-01 | 4.58e-01 | 0.16700 | 0.160000 | -0.047000 | 6.98e-02 | 5.95e-01 |
| REACTOME MEIOTIC SYNAPSIS | 15 | 5.28e-01 | 8.32e-01 | 0.16500 | 0.164000 | -0.015100 | 2.70e-01 | 9.19e-01 |
| REACTOME G PROTEIN ACTIVATION | 10 | 6.54e-01 | 9.06e-01 | 0.16500 | 0.016300 | -0.164000 | 9.29e-01 | 3.69e-01 |
| REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | 28 | 3.62e-01 | 7.15e-01 | 0.16400 | 0.088900 | 0.138000 | 4.16e-01 | 2.06e-01 |
| REACTOME POTASSIUM CHANNELS | 22 | 4.52e-01 | 7.87e-01 | 0.16400 | -0.137000 | -0.090400 | 2.66e-01 | 4.63e-01 |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 44 | 1.40e-01 | 4.57e-01 | 0.16400 | 0.150000 | -0.065800 | 8.56e-02 | 4.51e-01 |
| REACTOME RNA POL I TRANSCRIPTION | 26 | 3.31e-01 | 7.12e-01 | 0.16300 | 0.160000 | -0.032500 | 1.59e-01 | 7.74e-01 |
| REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | 14 | 5.89e-01 | 8.63e-01 | 0.16200 | -0.032700 | -0.158000 | 8.33e-01 | 3.05e-01 |
| REACTOME SYNTHESIS OF DNA | 61 | 8.73e-02 | 3.73e-01 | 0.16000 | 0.160000 | -0.016200 | 3.15e-02 | 8.28e-01 |
| REACTOME RNA POL I TRANSCRIPTION TERMINATION | 19 | 4.59e-01 | 7.89e-01 | 0.16000 | 0.157000 | -0.031700 | 2.37e-01 | 8.11e-01 |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 15 | 5.28e-01 | 8.32e-01 | 0.16000 | -0.060100 | 0.148000 | 6.87e-01 | 3.20e-01 |
| REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | 17 | 4.84e-01 | 8.06e-01 | 0.16000 | -0.064900 | 0.146000 | 6.44e-01 | 2.97e-01 |
| REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | 11 | 6.65e-01 | 9.06e-01 | 0.15800 | -0.018500 | -0.157000 | 9.15e-01 | 3.66e-01 |
| REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | 28 | 3.64e-01 | 7.15e-01 | 0.15800 | 0.032100 | 0.155000 | 7.69e-01 | 1.56e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | 11 | 6.71e-01 | 9.06e-01 | 0.15700 | 0.023900 | 0.156000 | 8.91e-01 | 3.72e-01 |
| REACTOME NUCLEOTIDE EXCISION REPAIR | 38 | 2.35e-01 | 5.88e-01 | 0.15700 | 0.157000 | -0.008420 | 9.44e-02 | 9.28e-01 |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 51 | 1.93e-01 | 5.43e-01 | 0.15600 | 0.113000 | 0.108000 | 1.64e-01 | 1.82e-01 |
| REACTOME PKB MEDIATED EVENTS | 27 | 4.18e-01 | 7.65e-01 | 0.15600 | 0.095800 | 0.123000 | 3.89e-01 | 2.69e-01 |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 95 | 3.42e-02 | 2.39e-01 | 0.15600 | 0.019300 | 0.155000 | 7.45e-01 | 9.38e-03 |
| REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | 14 | 5.61e-01 | 8.47e-01 | 0.15600 | 0.082900 | -0.132000 | 5.92e-01 | 3.93e-01 |
| REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | 18 | 4.90e-01 | 8.11e-01 | 0.15600 | -0.046800 | 0.149000 | 7.31e-01 | 2.76e-01 |
| REACTOME UNFOLDED PROTEIN RESPONSE | 64 | 8.39e-02 | 3.69e-01 | 0.15600 | -0.034100 | 0.152000 | 6.38e-01 | 3.60e-02 |
| REACTOME SHC MEDIATED CASCADE | 10 | 6.75e-01 | 9.06e-01 | 0.15500 | 0.041700 | -0.150000 | 8.19e-01 | 4.13e-01 |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 11 | 6.63e-01 | 9.06e-01 | 0.15400 | -0.153000 | 0.016400 | 3.78e-01 | 9.25e-01 |
| REACTOME PI 3K CASCADE | 34 | 3.08e-01 | 6.83e-01 | 0.15300 | 0.018600 | 0.152000 | 8.51e-01 | 1.25e-01 |
| REACTOME PYRIMIDINE METABOLISM | 10 | 7.29e-01 | 9.29e-01 | 0.15300 | -0.081800 | -0.130000 | 6.54e-01 | 4.78e-01 |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 41 | 2.04e-01 | 5.56e-01 | 0.15300 | 0.141000 | -0.059000 | 1.18e-01 | 5.14e-01 |
| REACTOME MEIOSIS | 25 | 3.92e-01 | 7.47e-01 | 0.15200 | 0.148000 | -0.036500 | 2.00e-01 | 7.52e-01 |
| REACTOME PI3K EVENTS IN ERBB2 SIGNALING | 32 | 3.56e-01 | 7.15e-01 | 0.15200 | 0.053400 | 0.143000 | 6.01e-01 | 1.63e-01 |
| REACTOME PIP3 ACTIVATES AKT SIGNALING | 25 | 4.51e-01 | 7.87e-01 | 0.15200 | 0.062300 | 0.139000 | 5.90e-01 | 2.30e-01 |
| REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | 24 | 4.51e-01 | 7.87e-01 | 0.15200 | 0.034100 | 0.148000 | 7.73e-01 | 2.10e-01 |
| REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | 56 | 1.17e-01 | 4.24e-01 | 0.15200 | 0.138000 | -0.061900 | 7.36e-02 | 4.24e-01 |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 10 | 6.74e-01 | 9.06e-01 | 0.15100 | 0.099700 | -0.114000 | 5.85e-01 | 5.32e-01 |
| REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | 13 | 6.73e-01 | 9.06e-01 | 0.15100 | 0.119000 | 0.093800 | 4.59e-01 | 5.58e-01 |
| REACTOME DOUBLE STRAND BREAK REPAIR | 12 | 6.86e-01 | 9.07e-01 | 0.15100 | 0.138000 | 0.060600 | 4.07e-01 | 7.16e-01 |
| REACTOME REGULATION OF APOPTOSIS | 49 | 1.91e-01 | 5.43e-01 | 0.15000 | 0.150000 | 0.008900 | 6.95e-02 | 9.14e-01 |
| REACTOME GLUCOSE METABOLISM | 44 | 2.07e-01 | 5.56e-01 | 0.15000 | 0.030000 | -0.147000 | 7.31e-01 | 9.25e-02 |
| REACTOME APOPTOTIC EXECUTION PHASE | 27 | 3.58e-01 | 7.15e-01 | 0.14900 | -0.105000 | 0.106000 | 3.46e-01 | 3.43e-01 |
| REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | 10 | 6.86e-01 | 9.07e-01 | 0.14900 | 0.125000 | -0.080100 | 4.93e-01 | 6.61e-01 |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 43 | 2.12e-01 | 5.56e-01 | 0.14800 | 0.138000 | -0.052800 | 1.18e-01 | 5.50e-01 |
| REACTOME MRNA CAPPING | 28 | 4.03e-01 | 7.55e-01 | 0.14800 | -0.012200 | -0.147000 | 9.11e-01 | 1.78e-01 |
| REACTOME L1CAM INTERACTIONS | 51 | 1.86e-01 | 5.37e-01 | 0.14700 | -0.004370 | 0.147000 | 9.57e-01 | 7.01e-02 |
| REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | 22 | 4.51e-01 | 7.87e-01 | 0.14600 | -0.128000 | 0.070300 | 2.97e-01 | 5.68e-01 |
| REACTOME RAP1 SIGNALLING | 12 | 6.51e-01 | 9.06e-01 | 0.14600 | -0.062400 | 0.132000 | 7.08e-01 | 4.28e-01 |
| REACTOME SPHINGOLIPID METABOLISM | 35 | 3.43e-01 | 7.15e-01 | 0.14600 | -0.031000 | -0.143000 | 7.51e-01 | 1.45e-01 |
| REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | 25 | 4.16e-01 | 7.65e-01 | 0.14600 | -0.054400 | 0.135000 | 6.38e-01 | 2.43e-01 |
| REACTOME IL1 SIGNALING | 23 | 4.36e-01 | 7.80e-01 | 0.14500 | 0.102000 | -0.103000 | 3.99e-01 | 3.91e-01 |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 49 | 2.57e-01 | 6.22e-01 | 0.14500 | 0.108000 | 0.096700 | 1.93e-01 | 2.42e-01 |
| REACTOME PROCESSING OF INTRONLESS PRE MRNAS | 12 | 6.79e-01 | 9.06e-01 | 0.14400 | -0.143000 | 0.012900 | 3.90e-01 | 9.38e-01 |
| REACTOME CELL CYCLE | 211 | 6.47e-04 | 1.25e-02 | 0.14400 | 0.106000 | -0.096900 | 8.27e-03 | 1.60e-02 |
| REACTOME PEROXISOMAL LIPID METABOLISM | 16 | 5.69e-01 | 8.47e-01 | 0.14300 | -0.086800 | 0.114000 | 5.48e-01 | 4.30e-01 |
| REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 51 | 2.51e-01 | 6.14e-01 | 0.14300 | 0.108000 | 0.093700 | 1.82e-01 | 2.48e-01 |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 43 | 2.34e-01 | 5.88e-01 | 0.14300 | 0.134000 | -0.050500 | 1.29e-01 | 5.67e-01 |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 57 | 1.46e-01 | 4.58e-01 | 0.14200 | 0.126000 | -0.065900 | 1.02e-01 | 3.90e-01 |
| REACTOME TRANSCRIPTION COUPLED NER TC NER | 35 | 3.35e-01 | 7.15e-01 | 0.14100 | 0.141000 | -0.015600 | 1.51e-01 | 8.73e-01 |
| REACTOME MEIOTIC RECOMBINATION | 10 | 7.15e-01 | 9.25e-01 | 0.14100 | 0.123000 | -0.068600 | 5.01e-01 | 7.07e-01 |
| REACTOME RNA POL I TRANSCRIPTION INITIATION | 23 | 4.66e-01 | 7.97e-01 | 0.14100 | 0.126000 | -0.062200 | 2.95e-01 | 6.06e-01 |
| REACTOME MITOTIC G1 G1 S PHASES | 84 | 6.37e-02 | 3.23e-01 | 0.14000 | 0.125000 | -0.063900 | 4.89e-02 | 3.13e-01 |
| REACTOME SIGNALING BY ERBB4 | 66 | 1.74e-01 | 5.18e-01 | 0.13900 | 0.129000 | 0.051400 | 7.10e-02 | 4.71e-01 |
| REACTOME ELONGATION ARREST AND RECOVERY | 24 | 4.58e-01 | 7.89e-01 | 0.13900 | 0.119000 | -0.070600 | 3.12e-01 | 5.50e-01 |
| REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 17 | 5.72e-01 | 8.47e-01 | 0.13900 | 0.080300 | -0.113000 | 5.67e-01 | 4.20e-01 |
| REACTOME RNA POL II TRANSCRIPTION | 83 | 1.11e-01 | 4.24e-01 | 0.13800 | 0.131000 | 0.044000 | 4.01e-02 | 4.90e-01 |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 49 | 2.10e-01 | 5.56e-01 | 0.13800 | 0.121000 | -0.065900 | 1.44e-01 | 4.26e-01 |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 98 | 5.88e-02 | 3.12e-01 | 0.13700 | 0.136000 | -0.014600 | 2.06e-02 | 8.03e-01 |
| REACTOME S PHASE | 71 | 1.20e-01 | 4.24e-01 | 0.13600 | 0.131000 | -0.035900 | 5.65e-02 | 6.02e-01 |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 43 | 2.59e-01 | 6.22e-01 | 0.13600 | 0.113000 | -0.075300 | 2.00e-01 | 3.94e-01 |
| REACTOME M G1 TRANSITION | 52 | 2.02e-01 | 5.56e-01 | 0.13600 | 0.123000 | -0.057200 | 1.25e-01 | 4.76e-01 |
| REACTOME MICRORNA MIRNA BIOGENESIS | 18 | 5.72e-01 | 8.47e-01 | 0.13600 | 0.121000 | -0.062500 | 3.76e-01 | 6.46e-01 |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 46 | 2.37e-01 | 5.89e-01 | 0.13600 | 0.112000 | -0.077000 | 1.91e-01 | 3.67e-01 |
| REACTOME G1 S TRANSITION | 69 | 1.31e-01 | 4.41e-01 | 0.13500 | 0.131000 | -0.035000 | 6.12e-02 | 6.16e-01 |
| REACTOME SMOOTH MUSCLE CONTRACTION | 18 | 6.45e-01 | 9.06e-01 | 0.13500 | 0.111000 | 0.076500 | 4.15e-01 | 5.74e-01 |
| REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 20 | 5.41e-01 | 8.33e-01 | 0.13500 | 0.117000 | -0.067300 | 3.67e-01 | 6.02e-01 |
| REACTOME CELL CYCLE MITOTIC | 187 | 3.61e-03 | 5.06e-02 | 0.13400 | 0.110000 | -0.076700 | 1.01e-02 | 7.22e-02 |
| REACTOME FORMATION OF INCISION COMPLEX IN GG NER | 17 | 6.60e-01 | 9.06e-01 | 0.13400 | 0.120000 | 0.060100 | 3.94e-01 | 6.68e-01 |
| REACTOME PI3K CASCADE | 45 | 3.06e-01 | 6.83e-01 | 0.13300 | 0.012200 | 0.133000 | 8.88e-01 | 1.24e-01 |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 51 | 2.33e-01 | 5.88e-01 | 0.13300 | 0.128000 | -0.035100 | 1.14e-01 | 6.65e-01 |
| REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | 12 | 7.59e-01 | 9.43e-01 | 0.13100 | 0.105000 | 0.078700 | 5.29e-01 | 6.37e-01 |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 24 | 5.04e-01 | 8.18e-01 | 0.13100 | 0.121000 | -0.050500 | 3.05e-01 | 6.69e-01 |
| REACTOME ARMS MEDIATED ACTIVATION | 14 | 7.23e-01 | 9.25e-01 | 0.13100 | -0.063300 | -0.114000 | 6.82e-01 | 4.59e-01 |
| REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | 17 | 6.79e-01 | 9.06e-01 | 0.13000 | -0.071000 | -0.109000 | 6.13e-01 | 4.36e-01 |
| REACTOME NOD1 2 SIGNALING PATHWAY | 17 | 6.17e-01 | 8.91e-01 | 0.12800 | 0.092000 | -0.089600 | 5.12e-01 | 5.23e-01 |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 51 | 3.12e-01 | 6.83e-01 | 0.12800 | -0.040600 | -0.121000 | 6.17e-01 | 1.35e-01 |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 40 | 3.39e-01 | 7.15e-01 | 0.12700 | -0.113000 | 0.057900 | 2.17e-01 | 5.27e-01 |
| REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | 10 | 7.87e-01 | 9.44e-01 | 0.12600 | -0.126000 | -0.007520 | 4.90e-01 | 9.67e-01 |
| REACTOME SIGNALING BY SCF KIT | 56 | 2.94e-01 | 6.67e-01 | 0.12600 | 0.116000 | 0.050500 | 1.35e-01 | 5.14e-01 |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 97 | 8.80e-02 | 3.73e-01 | 0.12600 | 0.124000 | -0.023500 | 3.59e-02 | 6.91e-01 |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 171 | 1.65e-02 | 1.73e-01 | 0.12600 | -0.005850 | 0.126000 | 8.96e-01 | 4.78e-03 |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 16 | 6.50e-01 | 9.06e-01 | 0.12500 | 0.092200 | -0.084500 | 5.23e-01 | 5.59e-01 |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 41 | 3.48e-01 | 7.15e-01 | 0.12400 | 0.109000 | -0.059400 | 2.30e-01 | 5.11e-01 |
| REACTOME SIGNALING BY ILS | 61 | 2.11e-01 | 5.56e-01 | 0.12300 | 0.106000 | -0.062200 | 1.53e-01 | 4.02e-01 |
| REACTOME AXON GUIDANCE | 142 | 2.96e-02 | 2.32e-01 | 0.12300 | -0.113000 | 0.048100 | 2.06e-02 | 3.25e-01 |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | 29 | 5.25e-01 | 8.32e-01 | 0.12200 | 0.011400 | 0.122000 | 9.16e-01 | 2.57e-01 |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 82 | 1.60e-01 | 4.82e-01 | 0.12200 | 0.122000 | 0.001900 | 5.70e-02 | 9.76e-01 |
| REACTOME GROWTH HORMONE RECEPTOR SIGNALING | 15 | 7.14e-01 | 9.25e-01 | 0.12100 | 0.121000 | -0.000188 | 4.16e-01 | 9.99e-01 |
| REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | 28 | 5.41e-01 | 8.33e-01 | 0.12100 | -0.003560 | -0.121000 | 9.74e-01 | 2.70e-01 |
| REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 12 | 7.58e-01 | 9.43e-01 | 0.12000 | 0.024400 | -0.118000 | 8.84e-01 | 4.81e-01 |
| REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | 13 | 7.80e-01 | 9.44e-01 | 0.12000 | 0.080200 | 0.089300 | 6.17e-01 | 5.78e-01 |
| REACTOME PI3K AKT ACTIVATION | 31 | 5.05e-01 | 8.18e-01 | 0.12000 | -0.003430 | 0.120000 | 9.74e-01 | 2.49e-01 |
| REACTOME ERKS ARE INACTIVATED | 10 | 7.96e-01 | 9.44e-01 | 0.12000 | 0.118000 | -0.021700 | 5.19e-01 | 9.05e-01 |
| REACTOME CALNEXIN CALRETICULIN CYCLE | 11 | 7.99e-01 | 9.44e-01 | 0.11900 | 0.026100 | 0.116000 | 8.81e-01 | 5.05e-01 |
| REACTOME SIGNALING BY INSULIN RECEPTOR | 73 | 2.56e-01 | 6.22e-01 | 0.11900 | 0.074800 | 0.092300 | 2.70e-01 | 1.74e-01 |
| REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 20 | 6.68e-01 | 9.06e-01 | 0.11700 | 0.017700 | 0.116000 | 8.91e-01 | 3.69e-01 |
| REACTOME PURINE METABOLISM | 27 | 6.11e-01 | 8.87e-01 | 0.11700 | 0.091200 | 0.073800 | 4.13e-01 | 5.07e-01 |
| REACTOME CIRCADIAN CLOCK | 42 | 4.58e-01 | 7.89e-01 | 0.11700 | 0.051400 | 0.105000 | 5.65e-01 | 2.41e-01 |
| REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | 38 | 4.25e-01 | 7.69e-01 | 0.11500 | -0.087600 | 0.074100 | 3.51e-01 | 4.30e-01 |
| REACTOME G ALPHA S SIGNALLING EVENTS | 28 | 5.51e-01 | 8.40e-01 | 0.11400 | -0.108000 | 0.036200 | 3.23e-01 | 7.41e-01 |
| REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA | 17 | 7.48e-01 | 9.42e-01 | 0.11300 | -0.083400 | -0.076900 | 5.52e-01 | 5.83e-01 |
| REACTOME MITOTIC M M G1 PHASES | 96 | 1.22e-01 | 4.27e-01 | 0.11300 | 0.081700 | -0.078600 | 1.68e-01 | 1.85e-01 |
| REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | 35 | 5.48e-01 | 8.38e-01 | 0.11200 | 0.050300 | 0.101000 | 6.07e-01 | 3.04e-01 |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 44 | 4.18e-01 | 7.65e-01 | 0.11200 | 0.110000 | -0.020500 | 2.08e-01 | 8.14e-01 |
| REACTOME DNA REPLICATION | 106 | 1.13e-01 | 4.24e-01 | 0.11100 | 0.099400 | -0.050000 | 7.81e-02 | 3.76e-01 |
| REACTOME INSULIN SYNTHESIS AND PROCESSING | 13 | 8.09e-01 | 9.50e-01 | 0.11100 | 0.080600 | 0.076400 | 6.15e-01 | 6.34e-01 |
| REACTOME SIGNALING BY WNT | 57 | 3.13e-01 | 6.83e-01 | 0.11000 | 0.051500 | -0.097300 | 5.02e-01 | 2.05e-01 |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 46 | 4.30e-01 | 7.76e-01 | 0.11000 | 0.110000 | 0.000209 | 1.98e-01 | 9.98e-01 |
| REACTOME METABOLISM OF NON CODING RNA | 42 | 5.08e-01 | 8.18e-01 | 0.11000 | 0.092300 | 0.059200 | 3.01e-01 | 5.07e-01 |
| REACTOME PLATELET AGGREGATION PLUG FORMATION | 18 | 7.32e-01 | 9.29e-01 | 0.10900 | -0.108000 | -0.019000 | 4.30e-01 | 8.89e-01 |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 12 | 8.26e-01 | 9.50e-01 | 0.10900 | -0.092000 | -0.058400 | 5.81e-01 | 7.26e-01 |
| REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | 14 | 7.70e-01 | 9.44e-01 | 0.10800 | -0.107000 | 0.017500 | 4.88e-01 | 9.10e-01 |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 61 | 3.40e-01 | 7.15e-01 | 0.10800 | -0.000115 | 0.108000 | 9.99e-01 | 1.45e-01 |
| REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 19 | 7.21e-01 | 9.25e-01 | 0.10800 | 0.011700 | 0.107000 | 9.30e-01 | 4.19e-01 |
| REACTOME SIGNALING BY GPCR | 143 | 6.65e-02 | 3.30e-01 | 0.10700 | -0.095700 | 0.047800 | 4.93e-02 | 3.26e-01 |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 36 | 5.90e-01 | 8.63e-01 | 0.10400 | 0.089800 | 0.053100 | 3.52e-01 | 5.82e-01 |
| REACTOME CA DEPENDENT EVENTS | 14 | 7.92e-01 | 9.44e-01 | 0.10400 | 0.005230 | -0.104000 | 9.73e-01 | 5.01e-01 |
| REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 34 | 5.66e-01 | 8.47e-01 | 0.10400 | 0.009780 | -0.103000 | 9.22e-01 | 2.98e-01 |
| REACTOME COMPLEMENT CASCADE | 11 | 8.23e-01 | 9.50e-01 | 0.10300 | 0.093700 | -0.042900 | 5.91e-01 | 8.06e-01 |
| REACTOME DEADENYLATION DEPENDENT MRNA DECAY | 37 | 5.12e-01 | 8.18e-01 | 0.10300 | 0.077900 | -0.067100 | 4.13e-01 | 4.81e-01 |
| REACTOME PROLONGED ERK ACTIVATION EVENTS | 16 | 8.00e-01 | 9.44e-01 | 0.10200 | -0.085500 | -0.055400 | 5.54e-01 | 7.02e-01 |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 17 | 7.51e-01 | 9.43e-01 | 0.10100 | -0.032300 | 0.095900 | 8.18e-01 | 4.94e-01 |
| REACTOME TRIGLYCERIDE BIOSYNTHESIS | 21 | 6.93e-01 | 9.07e-01 | 0.10100 | 0.057300 | -0.083300 | 6.49e-01 | 5.09e-01 |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 54 | 4.85e-01 | 8.06e-01 | 0.10100 | 0.075500 | 0.066600 | 3.38e-01 | 3.98e-01 |
| REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 17 | 8.01e-01 | 9.44e-01 | 0.09910 | -0.078800 | -0.060200 | 5.74e-01 | 6.68e-01 |
| REACTOME SIGNAL TRANSDUCTION BY L1 | 28 | 6.78e-01 | 9.06e-01 | 0.09890 | 0.026700 | 0.095200 | 8.07e-01 | 3.84e-01 |
| REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | 10 | 8.62e-01 | 9.59e-01 | 0.09880 | 0.098800 | 0.001190 | 5.89e-01 | 9.95e-01 |
| REACTOME GLUTATHIONE CONJUGATION | 12 | 8.23e-01 | 9.50e-01 | 0.09850 | 0.089000 | -0.042300 | 5.94e-01 | 8.00e-01 |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 47 | 4.78e-01 | 8.02e-01 | 0.09850 | 0.094700 | -0.027000 | 2.62e-01 | 7.49e-01 |
| REACTOME G0 AND EARLY G1 | 11 | 8.37e-01 | 9.52e-01 | 0.09780 | 0.087000 | -0.044700 | 6.17e-01 | 7.98e-01 |
| REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | 17 | 7.57e-01 | 9.43e-01 | 0.09770 | 0.061600 | -0.075800 | 6.60e-01 | 5.89e-01 |
| REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | 17 | 7.57e-01 | 9.43e-01 | 0.09770 | 0.061600 | -0.075800 | 6.60e-01 | 5.89e-01 |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 51 | 4.73e-01 | 8.00e-01 | 0.09730 | 0.096800 | -0.009080 | 2.32e-01 | 9.11e-01 |
| REACTOME DEVELOPMENTAL BIOLOGY | 240 | 2.38e-02 | 1.97e-01 | 0.09690 | -0.082100 | 0.051300 | 2.96e-02 | 1.74e-01 |
| REACTOME METABOLISM OF NUCLEOTIDES | 48 | 5.37e-01 | 8.33e-01 | 0.09640 | 0.032400 | 0.090800 | 6.98e-01 | 2.77e-01 |
| REACTOME SEMA4D IN SEMAPHORIN SIGNALING | 22 | 7.04e-01 | 9.17e-01 | 0.09630 | -0.068800 | 0.067300 | 5.77e-01 | 5.85e-01 |
| REACTOME SIGNAL AMPLIFICATION | 14 | 8.30e-01 | 9.50e-01 | 0.09620 | -0.093700 | -0.021900 | 5.44e-01 | 8.87e-01 |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 279 | 1.70e-02 | 1.74e-01 | 0.09600 | -0.091900 | 0.027700 | 8.83e-03 | 4.30e-01 |
| REACTOME PLC BETA MEDIATED EVENTS | 20 | 7.89e-01 | 9.44e-01 | 0.09420 | -0.055000 | -0.076400 | 6.71e-01 | 5.54e-01 |
| REACTOME ACTIVATED TLR4 SIGNALLING | 58 | 5.09e-01 | 8.18e-01 | 0.09400 | 0.067000 | 0.065900 | 3.78e-01 | 3.86e-01 |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 28 | 6.60e-01 | 9.06e-01 | 0.09400 | -0.084100 | 0.041900 | 4.42e-01 | 7.02e-01 |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 107 | 2.20e-01 | 5.70e-01 | 0.09370 | 0.089900 | -0.026400 | 1.09e-01 | 6.38e-01 |
| REACTOME G1 PHASE | 25 | 6.89e-01 | 9.07e-01 | 0.09320 | 0.072500 | -0.058500 | 5.31e-01 | 6.13e-01 |
| REACTOME HIV INFECTION | 155 | 1.25e-01 | 4.31e-01 | 0.09300 | 0.092200 | -0.012300 | 4.88e-02 | 7.93e-01 |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 187 | 6.57e-02 | 3.30e-01 | 0.09290 | 0.068800 | -0.062400 | 1.07e-01 | 1.44e-01 |
| REACTOME MITOTIC PROMETAPHASE | 43 | 5.43e-01 | 8.33e-01 | 0.09280 | 0.032900 | -0.086800 | 7.09e-01 | 3.26e-01 |
| REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | 20 | 7.74e-01 | 9.44e-01 | 0.09140 | 0.003720 | -0.091300 | 9.77e-01 | 4.80e-01 |
| REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 46 | 5.63e-01 | 8.47e-01 | 0.09120 | -0.091100 | -0.003200 | 2.86e-01 | 9.70e-01 |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 64 | 4.94e-01 | 8.14e-01 | 0.09110 | -0.055400 | -0.072400 | 4.45e-01 | 3.18e-01 |
| REACTOME GABA B RECEPTOR ACTIVATION | 14 | 8.59e-01 | 9.58e-01 | 0.08980 | 0.077200 | 0.045900 | 6.17e-01 | 7.66e-01 |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 139 | 1.50e-01 | 4.63e-01 | 0.08970 | 0.061200 | -0.065500 | 2.15e-01 | 1.84e-01 |
| REACTOME GAB1 SIGNALOSOME | 32 | 6.87e-01 | 9.07e-01 | 0.08960 | 0.013500 | 0.088500 | 8.95e-01 | 3.87e-01 |
| REACTOME SIGNALING BY FGFR MUTANTS | 26 | 7.63e-01 | 9.43e-01 | 0.08860 | -0.064100 | -0.061200 | 5.72e-01 | 5.90e-01 |
| REACTOME DESTABILIZATION OF MRNA BY BRF1 | 16 | 8.46e-01 | 9.53e-01 | 0.08750 | 0.038300 | 0.078700 | 7.91e-01 | 5.86e-01 |
| REACTOME G ALPHA I SIGNALLING EVENTS | 28 | 7.48e-01 | 9.42e-01 | 0.08720 | 0.039000 | 0.078000 | 7.21e-01 | 4.75e-01 |
| REACTOME DOWNSTREAM TCR SIGNALING | 20 | 7.94e-01 | 9.44e-01 | 0.08630 | -0.086200 | 0.005130 | 5.05e-01 | 9.68e-01 |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 14 | 8.39e-01 | 9.52e-01 | 0.08570 | -0.070300 | 0.049000 | 6.49e-01 | 7.51e-01 |
| REACTOME METABOLISM OF PORPHYRINS | 11 | 8.76e-01 | 9.61e-01 | 0.08560 | 0.081300 | -0.027100 | 6.41e-01 | 8.76e-01 |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 55 | 5.84e-01 | 8.59e-01 | 0.08560 | 0.071300 | 0.047400 | 3.61e-01 | 5.44e-01 |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 162 | 1.35e-01 | 4.52e-01 | 0.08550 | 0.059800 | -0.061100 | 1.92e-01 | 1.82e-01 |
| REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | 21 | 7.74e-01 | 9.44e-01 | 0.08520 | -0.037300 | 0.076600 | 7.67e-01 | 5.44e-01 |
| REACTOME NEURONAL SYSTEM | 89 | 4.12e-01 | 7.65e-01 | 0.08500 | -0.079100 | -0.031100 | 1.98e-01 | 6.13e-01 |
| REACTOME ENOS ACTIVATION AND REGULATION | 12 | 8.86e-01 | 9.68e-01 | 0.08470 | -0.080200 | -0.027400 | 6.31e-01 | 8.69e-01 |
| REACTOME DIABETES PATHWAYS | 91 | 3.63e-01 | 7.15e-01 | 0.08410 | -0.013800 | 0.082900 | 8.21e-01 | 1.73e-01 |
| REACTOME CD28 CO STIMULATION | 21 | 7.78e-01 | 9.44e-01 | 0.08370 | -0.048100 | 0.068500 | 7.03e-01 | 5.87e-01 |
| REACTOME MAP KINASE ACTIVATION IN TLR CASCADE | 40 | 6.91e-01 | 9.07e-01 | 0.08360 | 0.053100 | 0.064600 | 5.62e-01 | 4.80e-01 |
| REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | 37 | 6.74e-01 | 9.06e-01 | 0.08230 | -0.011400 | 0.081500 | 9.04e-01 | 3.91e-01 |
| REACTOME DAG AND IP3 SIGNALING | 16 | 8.45e-01 | 9.53e-01 | 0.08230 | 0.006360 | -0.082000 | 9.65e-01 | 5.70e-01 |
| REACTOME INNATE IMMUNE SYSTEM | 116 | 3.12e-01 | 6.83e-01 | 0.08180 | 0.081800 | 0.000811 | 1.30e-01 | 9.88e-01 |
| REACTOME OPIOID SIGNALLING | 39 | 6.46e-01 | 9.06e-01 | 0.08150 | 0.039200 | -0.071400 | 6.72e-01 | 4.41e-01 |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 84 | 4.71e-01 | 8.00e-01 | 0.08130 | 0.073100 | 0.035500 | 2.48e-01 | 5.75e-01 |
| REACTOME LYSOSOME VESICLE BIOGENESIS | 17 | 8.26e-01 | 9.50e-01 | 0.08090 | 0.063800 | -0.049700 | 6.49e-01 | 7.23e-01 |
| REACTOME HIV LIFE CYCLE | 92 | 4.19e-01 | 7.65e-01 | 0.08070 | 0.079800 | 0.012100 | 1.87e-01 | 8.42e-01 |
| REACTOME GABA RECEPTOR ACTIVATION | 15 | 8.69e-01 | 9.59e-01 | 0.07970 | 0.009130 | 0.079200 | 9.51e-01 | 5.96e-01 |
| REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | 11 | 8.96e-01 | 9.71e-01 | 0.07960 | 0.010800 | -0.078900 | 9.51e-01 | 6.51e-01 |
| REACTOME PRE NOTCH EXPRESSION AND PROCESSING | 31 | 7.31e-01 | 9.29e-01 | 0.07750 | -0.067800 | 0.037400 | 5.14e-01 | 7.19e-01 |
| REACTOME G ALPHA Z SIGNALLING EVENTS | 21 | 8.11e-01 | 9.50e-01 | 0.07670 | 0.040100 | -0.065400 | 7.50e-01 | 6.04e-01 |
| REACTOME HEMOSTASIS | 211 | 1.65e-01 | 4.96e-01 | 0.07670 | -0.076300 | -0.008050 | 5.78e-02 | 8.41e-01 |
| REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX | 35 | 7.18e-01 | 9.25e-01 | 0.07640 | 0.021100 | -0.073400 | 8.29e-01 | 4.53e-01 |
| REACTOME SIGNALING BY NODAL | 11 | 8.98e-01 | 9.71e-01 | 0.07600 | 0.039300 | -0.065100 | 8.22e-01 | 7.09e-01 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 10 | 9.15e-01 | 9.78e-01 | 0.07590 | -0.075700 | 0.005170 | 6.79e-01 | 9.77e-01 |
| REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 51 | 6.48e-01 | 9.06e-01 | 0.07570 | -0.075500 | -0.006460 | 3.52e-01 | 9.36e-01 |
| REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | 18 | 8.69e-01 | 9.59e-01 | 0.07510 | 0.069000 | 0.029500 | 6.12e-01 | 8.28e-01 |
| REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 59 | 6.49e-01 | 9.06e-01 | 0.07460 | 0.052700 | 0.052800 | 4.85e-01 | 4.84e-01 |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 21 | 8.51e-01 | 9.54e-01 | 0.07320 | -0.016200 | -0.071400 | 8.98e-01 | 5.71e-01 |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 21 | 8.51e-01 | 9.54e-01 | 0.07320 | -0.016200 | -0.071400 | 8.98e-01 | 5.71e-01 |
| REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION | 98 | 4.22e-01 | 7.68e-01 | 0.07310 | 0.028000 | -0.067500 | 6.34e-01 | 2.50e-01 |
| REACTOME SIGNALING BY NOTCH4 | 10 | 9.31e-01 | 9.78e-01 | 0.07260 | -0.033800 | -0.064300 | 8.53e-01 | 7.25e-01 |
| REACTOME PI METABOLISM | 37 | 7.63e-01 | 9.43e-01 | 0.07150 | 0.017400 | 0.069400 | 8.55e-01 | 4.66e-01 |
| REACTOME EFFECTS OF PIP2 HYDROLYSIS | 13 | 9.16e-01 | 9.78e-01 | 0.07150 | 0.051100 | 0.050000 | 7.50e-01 | 7.55e-01 |
| REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | 10 | 9.34e-01 | 9.78e-01 | 0.07130 | 0.060900 | 0.037200 | 7.39e-01 | 8.39e-01 |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 52 | 7.01e-01 | 9.15e-01 | 0.07120 | 0.061600 | 0.035800 | 4.43e-01 | 6.56e-01 |
| REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 23 | 8.22e-01 | 9.50e-01 | 0.07040 | -0.049900 | 0.049700 | 6.79e-01 | 6.80e-01 |
| REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 21 | 8.63e-01 | 9.59e-01 | 0.07020 | 0.018100 | 0.067800 | 8.86e-01 | 5.91e-01 |
| REACTOME SIGNALING BY ERBB2 | 68 | 6.41e-01 | 9.06e-01 | 0.06810 | 0.065500 | 0.018600 | 3.51e-01 | 7.91e-01 |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 19 | 8.72e-01 | 9.60e-01 | 0.06790 | 0.067700 | -0.005880 | 6.10e-01 | 9.65e-01 |
| REACTOME SIGNALING BY NOTCH1 | 50 | 6.91e-01 | 9.07e-01 | 0.06780 | 0.015800 | -0.065900 | 8.47e-01 | 4.21e-01 |
| REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | 43 | 7.67e-01 | 9.44e-01 | 0.06400 | 0.001630 | 0.064000 | 9.85e-01 | 4.68e-01 |
| REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | 36 | 7.91e-01 | 9.44e-01 | 0.06360 | 0.061900 | -0.014700 | 5.21e-01 | 8.79e-01 |
| REACTOME SIGNALING BY PDGF | 85 | 5.61e-01 | 8.47e-01 | 0.06340 | -0.035300 | 0.052600 | 5.75e-01 | 4.03e-01 |
| REACTOME INTERFERON SIGNALING | 76 | 6.12e-01 | 8.87e-01 | 0.06300 | 0.060000 | -0.019200 | 3.67e-01 | 7.73e-01 |
| REACTOME ASPARAGINE N LINKED GLYCOSYLATION | 62 | 6.62e-01 | 9.06e-01 | 0.06240 | 0.043500 | -0.044700 | 5.55e-01 | 5.43e-01 |
| REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 17 | 8.94e-01 | 9.71e-01 | 0.06230 | -0.051800 | 0.034600 | 7.12e-01 | 8.05e-01 |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 48 | 7.48e-01 | 9.42e-01 | 0.06210 | 0.061500 | -0.008250 | 4.62e-01 | 9.21e-01 |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 106 | 5.19e-01 | 8.27e-01 | 0.06060 | -0.051900 | 0.031300 | 3.57e-01 | 5.79e-01 |
| REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 60 | 7.23e-01 | 9.25e-01 | 0.06030 | 0.060200 | 0.004510 | 4.21e-01 | 9.52e-01 |
| REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | 15 | 9.28e-01 | 9.78e-01 | 0.06030 | -0.028000 | -0.053400 | 8.51e-01 | 7.20e-01 |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 332 | 1.83e-01 | 5.37e-01 | 0.05790 | 0.008220 | -0.057300 | 7.99e-01 | 7.56e-02 |
| REACTOME SIGNALLING TO ERKS | 28 | 8.54e-01 | 9.55e-01 | 0.05730 | 0.041300 | -0.039800 | 7.06e-01 | 7.16e-01 |
| REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | 16 | 9.26e-01 | 9.78e-01 | 0.05520 | 0.009460 | -0.054300 | 9.48e-01 | 7.07e-01 |
| REACTOME REGULATION OF SIGNALING BY CBL | 13 | 9.49e-01 | 9.90e-01 | 0.05490 | -0.043800 | -0.033200 | 7.85e-01 | 8.36e-01 |
| REACTOME ERK MAPK TARGETS | 18 | 9.17e-01 | 9.78e-01 | 0.05490 | -0.011500 | 0.053700 | 9.33e-01 | 6.94e-01 |
| REACTOME MHC CLASS II ANTIGEN PRESENTATION | 59 | 7.83e-01 | 9.44e-01 | 0.05470 | -0.019400 | -0.051100 | 7.97e-01 | 4.98e-01 |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 15 | 9.28e-01 | 9.78e-01 | 0.05440 | -0.026200 | 0.047700 | 8.61e-01 | 7.49e-01 |
| REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | 10 | 9.55e-01 | 9.92e-01 | 0.05430 | 0.054000 | -0.005190 | 7.67e-01 | 9.77e-01 |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 11 | 9.56e-01 | 9.92e-01 | 0.05410 | -0.051800 | -0.015800 | 7.66e-01 | 9.28e-01 |
| REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | 16 | 9.27e-01 | 9.78e-01 | 0.05340 | 0.048500 | -0.022300 | 7.37e-01 | 8.77e-01 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 135 | 5.81e-01 | 8.57e-01 | 0.05320 | 0.011100 | 0.052000 | 8.24e-01 | 2.99e-01 |
| REACTOME METABOLISM OF CARBOHYDRATES | 129 | 5.72e-01 | 8.47e-01 | 0.05050 | -0.032300 | 0.038900 | 5.28e-01 | 4.48e-01 |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 73 | 7.73e-01 | 9.44e-01 | 0.05050 | 0.047300 | 0.017600 | 4.86e-01 | 7.95e-01 |
| REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 43 | 8.32e-01 | 9.50e-01 | 0.05000 | 0.035300 | -0.035400 | 6.89e-01 | 6.89e-01 |
| REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 24 | 9.06e-01 | 9.78e-01 | 0.04990 | 0.046400 | -0.018500 | 6.94e-01 | 8.76e-01 |
| REACTOME REGULATORY RNA PATHWAYS | 21 | 9.25e-01 | 9.78e-01 | 0.04970 | 0.049700 | 0.001110 | 6.94e-01 | 9.93e-01 |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 53 | 8.22e-01 | 9.50e-01 | 0.04700 | 0.022100 | -0.041400 | 7.81e-01 | 6.02e-01 |
| REACTOME TOLL RECEPTOR CASCADES | 70 | 8.15e-01 | 9.50e-01 | 0.04630 | 0.020400 | 0.041600 | 7.69e-01 | 5.48e-01 |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 58 | 8.32e-01 | 9.50e-01 | 0.04330 | -0.037400 | 0.021800 | 6.23e-01 | 7.74e-01 |
| REACTOME SYNTHESIS OF PA | 11 | 9.73e-01 | 9.94e-01 | 0.04290 | 0.020100 | 0.037900 | 9.08e-01 | 8.28e-01 |
| REACTOME IMMUNE SYSTEM | 503 | 2.45e-01 | 6.03e-01 | 0.04140 | 0.030300 | -0.028200 | 2.52e-01 | 2.87e-01 |
| REACTOME EGFR DOWNREGULATION | 23 | 9.35e-01 | 9.78e-01 | 0.04130 | -0.022500 | 0.034600 | 8.52e-01 | 7.74e-01 |
| REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | 13 | 9.71e-01 | 9.94e-01 | 0.03930 | 0.006400 | 0.038800 | 9.68e-01 | 8.09e-01 |
| REACTOME SIGNALING BY FGFR IN DISEASE | 81 | 8.16e-01 | 9.50e-01 | 0.03840 | 0.030200 | -0.023700 | 6.39e-01 | 7.13e-01 |
| REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 20 | 9.60e-01 | 9.94e-01 | 0.03830 | -0.013200 | -0.035900 | 9.19e-01 | 7.81e-01 |
| REACTOME SIGNALING BY FGFR | 69 | 8.67e-01 | 9.59e-01 | 0.03720 | 0.037200 | 0.001190 | 5.94e-01 | 9.86e-01 |
| REACTOME SIGNALING BY EGFR IN CANCER | 83 | 8.45e-01 | 9.53e-01 | 0.03530 | 0.033600 | -0.011000 | 5.98e-01 | 8.62e-01 |
| REACTOME SIGNALING BY NOTCH | 74 | 8.90e-01 | 9.69e-01 | 0.03460 | -0.021800 | -0.026900 | 7.47e-01 | 6.90e-01 |
| REACTOME SIGNALLING BY NGF | 153 | 7.87e-01 | 9.44e-01 | 0.03370 | 0.011500 | 0.031700 | 8.08e-01 | 5.01e-01 |
| REACTOME KERATAN SULFATE BIOSYNTHESIS | 11 | 9.81e-01 | 9.96e-01 | 0.03310 | -0.032400 | 0.007030 | 8.53e-01 | 9.68e-01 |
| REACTOME MITOTIC G2 G2 M PHASES | 49 | 9.32e-01 | 9.78e-01 | 0.03310 | -0.025100 | -0.021500 | 7.62e-01 | 7.95e-01 |
| REACTOME KERATAN SULFATE KERATIN METABOLISM | 14 | 9.74e-01 | 9.94e-01 | 0.03300 | 0.022100 | -0.024600 | 8.86e-01 | 8.74e-01 |
| REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | 31 | 9.62e-01 | 9.94e-01 | 0.03070 | -0.019600 | -0.023700 | 8.51e-01 | 8.20e-01 |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 101 | 8.80e-01 | 9.63e-01 | 0.03000 | 0.007210 | 0.029100 | 9.01e-01 | 6.15e-01 |
| REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | 27 | 9.69e-01 | 9.94e-01 | 0.02660 | 0.010800 | -0.024300 | 9.23e-01 | 8.27e-01 |
| REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 71 | 9.29e-01 | 9.78e-01 | 0.02480 | 0.013300 | -0.021000 | 8.46e-01 | 7.61e-01 |
| REACTOME SPRY REGULATION OF FGF SIGNALING | 12 | 9.89e-01 | 9.96e-01 | 0.02470 | 0.001960 | 0.024600 | 9.91e-01 | 8.83e-01 |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 32 | 9.75e-01 | 9.94e-01 | 0.02360 | -0.022800 | -0.006300 | 8.24e-01 | 9.51e-01 |
| REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | 12 | 9.92e-01 | 9.96e-01 | 0.02220 | 0.009510 | 0.020000 | 9.55e-01 | 9.05e-01 |
| REACTOME APOPTOSIS | 96 | 9.34e-01 | 9.78e-01 | 0.02070 | 0.019000 | -0.008350 | 7.48e-01 | 8.88e-01 |
| REACTOME REGULATION OF INSULIN SECRETION | 39 | 9.81e-01 | 9.96e-01 | 0.01800 | 0.017900 | 0.001920 | 8.47e-01 | 9.83e-01 |
| REACTOME SIGNALING BY FGFR1 MUTANTS | 20 | 9.92e-01 | 9.96e-01 | 0.01750 | -0.010700 | -0.013800 | 9.34e-01 | 9.15e-01 |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 62 | 9.73e-01 | 9.94e-01 | 0.01650 | 0.015200 | -0.006240 | 8.36e-01 | 9.32e-01 |
| REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | 14 | 9.95e-01 | 9.97e-01 | 0.01560 | 0.015400 | 0.002580 | 9.21e-01 | 9.87e-01 |
| REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | 38 | 9.90e-01 | 9.96e-01 | 0.01310 | 0.013100 | -0.000327 | 8.89e-01 | 9.97e-01 |
| REACTOME PHOSPHOLIPID METABOLISM | 114 | 9.88e-01 | 9.96e-01 | 0.00810 | -0.007800 | 0.002190 | 8.86e-01 | 9.68e-01 |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 14 | 1.00e+00 | 1.00e+00 | 0.00311 | -0.000761 | 0.003010 | 9.96e-01 | 9.84e-01 |
Detailed Gene set reports
REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 3.62e-09 |
| p.adjustMANOVA | 1.04e-07 |
| s.dist | 0.799 |
| s.ctrl | -0.784 |
| s.Acss2KD | 0.155 |
| p.ctrl | 3.23e-09 |
| p.Acss2KD | 0.242 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Fh1 | -3688 | 2783 |
| Idh3b | -3394 | 2629 |
| Ogdh | -3389 | 2604 |
| Dld | -2931 | 2747 |
| Sucla2 | -3523 | 1950 |
| Sdhb | -4362 | 1552 |
| Dlst | -3144 | 1623 |
| Suclg1 | -3852 | 1041 |
| Nnt | -4248 | 797 |
| Aco2 | -1645 | 1948 |
| Idh3a | -3237 | 509 |
| Idh3g | -3533 | 173 |
| Sdhd | -3740 | 6 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Aco2 | -1645 | 1948 |
| Cs | -3381 | -821 |
| Dld | -2931 | 2747 |
| Dlst | -3144 | 1623 |
| Fh1 | -3688 | 2783 |
| Idh2 | -4392 | -344 |
| Idh3a | -3237 | 509 |
| Idh3b | -3394 | 2629 |
| Idh3g | -3533 | 173 |
| Mdh2 | -4028 | -1792 |
| Nnt | -4248 | 797 |
| Ogdh | -3389 | 2604 |
| Sdha | -3787 | -290 |
| Sdhb | -4362 | 1552 |
| Sdhc | -3581 | -767 |
| Sdhd | -3740 | 6 |
| Sucla2 | -3523 | 1950 |
| Suclg1 | -3852 | 1041 |
| Suclg2 | -3306 | -3226 |
REACTOME_PEPTIDE_CHAIN_ELONGATION
| metric | value |
|---|---|
| setSize | 66 |
| pMANOVA | 2.57e-26 |
| p.adjustMANOVA | 3.95e-24 |
| s.dist | 0.741 |
| s.ctrl | 0.715 |
| s.Acss2KD | -0.196 |
| p.ctrl | 9.48e-24 |
| p.Acss2KD | 0.00589 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Rpl38 | 4075 | -2266 |
| Rpl36al | 4092 | -2051 |
| Rpl19 | 4402 | -1857 |
| Rps25 | 4326 | -1875 |
| Rps7 | 3597 | -2184 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Eef1a1 | 3477.0 | -2105.0 |
| Eef2 | 4494.0 | -509.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Uba52 | 1296.0 | 738.0 |
REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 1.3e-05 |
| p.adjustMANOVA | 0.000287 |
| s.dist | 0.722 |
| s.ctrl | -0.674 |
| s.Acss2KD | 0.261 |
| p.ctrl | 2.61e-05 |
| p.Acss2KD | 0.103 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Acadvl | -4365 | 2909 |
| Acadl | -3819 | 3233 |
| Pcca | -2815 | 3782 |
| Hadhb | -4344 | 1789 |
| Hadha | -3660 | 1557 |
| Decr1 | -4220 | 1138 |
| Eci1 | -4414 | 1075 |
| Acads | -3743 | 836 |
| Acadm | -4333 | 232 |
| Mcee | -1990 | 426 |
| Echs1 | -67 | 1818 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Acadl | -3819 | 3233 |
| Acadm | -4333 | 232 |
| Acads | -3743 | 836 |
| Acadvl | -4365 | 2909 |
| Decr1 | -4220 | 1138 |
| Echs1 | -67 | 1818 |
| Eci1 | -4414 | 1075 |
| Hadh | -4161 | -2985 |
| Hadha | -3660 | 1557 |
| Hadhb | -4344 | 1789 |
| Mcee | -1990 | 426 |
| Pcca | -2815 | 3782 |
| Pccb | 2571 | -499 |
REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
| metric | value |
|---|---|
| setSize | 41 |
| pMANOVA | 7.95e-16 |
| p.adjustMANOVA | 3.06e-14 |
| s.dist | 0.72 |
| s.ctrl | 0.686 |
| s.Acss2KD | -0.217 |
| p.ctrl | 2.9e-14 |
| p.Acss2KD | 0.0164 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rps9 | 4321 | -2721 |
| Rps14 | 3836 | -2815 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Eif3j2 | 2508 | -3837 |
| Rps25 | 4326 | -1875 |
| Rps7 | 3597 | -2184 |
| Eif3b | 3353 | -1965 |
| Rps11 | 1663 | -3764 |
| Eif3i | 3800 | -1632 |
| Rps29 | 2286 | -2584 |
| Eif3f | 2064 | -2807 |
| Rps6 | 3758 | -1321 |
| Rps23 | 4232 | -1084 |
| Eif3g | 3427 | -1282 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Eif1ax | -807 | -1287 |
| Eif2s1 | -1448 | -2281 |
| Eif2s2 | 2496 | -1744 |
| Eif2s3x | 4435 | 2022 |
| Eif3a | 3552 | 739 |
| Eif3b | 3353 | -1965 |
| Eif3c | 3576 | -1138 |
| Eif3d | 3308 | -894 |
| Eif3e | 4230 | 3083 |
| Eif3f | 2064 | -2807 |
| Eif3g | 3427 | -1282 |
| Eif3h | 830 | 4152 |
| Eif3i | 3800 | -1632 |
| Eif3j2 | 2508 | -3837 |
| Eif3k | 2040 | 2530 |
| Rps11 | 1663 | -3764 |
| Rps13 | 3015 | 2086 |
| Rps14 | 3836 | -2815 |
| Rps15a | 3088 | -125 |
| Rps16 | 4110 | -301 |
| Rps17 | 2325 | 319 |
| Rps18 | 3501 | -889 |
| Rps19 | 4264 | -190 |
| Rps20 | 3843 | -2669 |
| Rps21 | 3981 | -3337 |
| Rps23 | 4232 | -1084 |
| Rps24 | 4124 | -3163 |
| Rps25 | 4326 | -1875 |
| Rps26 | 3438 | -2966 |
| Rps27 | 4015 | -3368 |
| Rps27a | 2463 | 645 |
| Rps29 | 2286 | -2584 |
| Rps3 | 4276 | 1036 |
| Rps3a1 | 4505 | -891 |
| Rps4x | 4410 | -2262 |
| Rps5 | 4148 | 2414 |
| Rps6 | 3758 | -1321 |
| Rps7 | 3597 | -2184 |
| Rps8 | 2870 | -3674 |
| Rps9 | 4321 | -2721 |
| Rpsa | 4244 | 273 |
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
| metric | value |
|---|---|
| setSize | 59 |
| pMANOVA | 1.07e-19 |
| p.adjustMANOVA | 6.17e-18 |
| s.dist | 0.692 |
| s.ctrl | -0.691 |
| s.Acss2KD | 0.0419 |
| p.ctrl | 4.36e-20 |
| p.Acss2KD | 0.579 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Ndufb2 | -3309 | 3795 |
| Ndufb5 | -3877 | 3221 |
| Cycs | -4176 | 2966 |
| Cox6c | -4072 | 2901 |
| Ndufs8 | -3627 | 3195 |
| Ndufb10 | -3729 | 2967 |
| Etfa | -3966 | 2436 |
| Etfdh | -3947 | 2380 |
| Ndufs1 | -4168 | 2070 |
| Ndufa2 | -3099 | 2368 |
| Sdhb | -4362 | 1552 |
| Uqcrc2 | -3813 | 1706 |
| Ndufab1 | -3471 | 1855 |
| Ndufa9 | -3950 | 1597 |
| Ndufb4 | -3294 | 1551 |
| Ndufa5 | -3861 | 1274 |
| Ndufa4 | -3304 | 1436 |
| Ndufv2 | -2787 | 1647 |
| Uqcrq | -4320 | 1028 |
| Ndufs2 | -1622 | 2229 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Cox4i1 | -3891 | -613 |
| Cox5a | -3039 | -256 |
| Cox6a1 | 3247 | 3373 |
| Cox6b1 | -3845 | 258 |
| Cox6c | -4072 | 2901 |
| Cox7a2l | -2648 | -165 |
| Cox7c | -3797 | -1667 |
| Cox8a | 2222 | -2160 |
| Cyc1 | -4021 | -22 |
| Cycs | -4176 | 2966 |
| Etfa | -3966 | 2436 |
| Etfb | -3983 | -764 |
| Etfdh | -3947 | 2380 |
| Ndufa1 | -2755 | -2153 |
| Ndufa10 | -2708 | 790 |
| Ndufa11 | -4179 | -1782 |
| Ndufa12 | 103 | 1373 |
| Ndufa13 | -1962 | -3304 |
| Ndufa2 | -3099 | 2368 |
| Ndufa3 | -3455 | 762 |
| Ndufa4 | -3304 | 1436 |
| Ndufa5 | -3861 | 1274 |
| Ndufa6 | -3379 | 945 |
| Ndufa7 | -862 | -1839 |
| Ndufa8 | -3177 | 423 |
| Ndufa9 | -3950 | 1597 |
| Ndufab1 | -3471 | 1855 |
| Ndufb10 | -3729 | 2967 |
| Ndufb2 | -3309 | 3795 |
| Ndufb3 | -4374 | 322 |
| Ndufb4 | -3294 | 1551 |
| Ndufb5 | -3877 | 3221 |
| Ndufb6 | -3670 | -1929 |
| Ndufb7 | -3801 | -2700 |
| Ndufb9 | -3345 | -594 |
| Ndufc1 | -3299 | -137 |
| Ndufc2 | -1431 | -852 |
| Ndufs1 | -4168 | 2070 |
| Ndufs2 | -1622 | 2229 |
| Ndufs3 | -1691 | -1444 |
| Ndufs4 | -4022 | -743 |
| Ndufs5 | -2868 | -2028 |
| Ndufs6 | -4112 | -1253 |
| Ndufs7 | -2344 | -2877 |
| Ndufs8 | -3627 | 3195 |
| Ndufv1 | -4367 | -3206 |
| Ndufv2 | -2787 | 1647 |
| Ndufv3 | 36 | -2718 |
| Sdha | -3787 | -290 |
| Sdhb | -4362 | 1552 |
| Sdhc | -3581 | -767 |
| Sdhd | -3740 | 6 |
| Uqcr11 | -2210 | -3868 |
| Uqcrb | -3575 | -35 |
| Uqcrc1 | -4192 | -1083 |
| Uqcrc2 | -3813 | 1706 |
| Uqcrfs1 | -4017 | -240 |
| Uqcrh | -3064 | -975 |
| Uqcrq | -4320 | 1028 |
REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000222 |
| p.adjustMANOVA | 0.00447 |
| s.dist | 0.687 |
| s.ctrl | -0.684 |
| s.Acss2KD | -0.0687 |
| p.ctrl | 4.14e-05 |
| p.Acss2KD | 0.681 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Atp5j2 | -4065 | -2929 |
| Atp5j | -3639 | -1702 |
| Atp5d | -1717 | -1664 |
| Atp5h | -1884 | -1236 |
| Atp5k | -3446 | -425 |
| Atp5a1 | -3393 | -325 |
| Atp5e | -1772 | -595 |
| Atp5l | -3469 | -113 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Atp5a1 | -3393 | -325 |
| Atp5b | -3297 | 78 |
| Atp5c1 | -3225 | 2863 |
| Atp5d | -1717 | -1664 |
| Atp5e | -1772 | -595 |
| Atp5g1 | -4142 | 980 |
| Atp5h | -1884 | -1236 |
| Atp5j | -3639 | -1702 |
| Atp5j2 | -4065 | -2929 |
| Atp5k | -3446 | -425 |
| Atp5l | -3469 | -113 |
| Atp5o | -2838 | 1000 |
REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 1.86e-16 |
| p.adjustMANOVA | 8.61e-15 |
| s.dist | 0.683 |
| s.ctrl | 0.66 |
| s.Acss2KD | -0.172 |
| p.ctrl | 2.43e-15 |
| p.Acss2KD | 0.0393 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rps9 | 4321 | -2721 |
| Rps14 | 3836 | -2815 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Eif3j2 | 2508 | -3837 |
| Eif4h | 3551 | -2504 |
| Rps25 | 4326 | -1875 |
| Rps7 | 3597 | -2184 |
| Eif3b | 3353 | -1965 |
| Rps11 | 1663 | -3764 |
| Eif3i | 3800 | -1632 |
| Rps29 | 2286 | -2584 |
| Eif3f | 2064 | -2807 |
| Eif4a1 | 1522 | -3726 |
| Rps6 | 3758 | -1321 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Eif1ax | -807 | -1287 |
| Eif2s1 | -1448 | -2281 |
| Eif2s2 | 2496 | -1744 |
| Eif2s3x | 4435 | 2022 |
| Eif3a | 3552 | 739 |
| Eif3b | 3353 | -1965 |
| Eif3c | 3576 | -1138 |
| Eif3d | 3308 | -894 |
| Eif3e | 4230 | 3083 |
| Eif3f | 2064 | -2807 |
| Eif3g | 3427 | -1282 |
| Eif3h | 830 | 4152 |
| Eif3i | 3800 | -1632 |
| Eif3j2 | 2508 | -3837 |
| Eif3k | 2040 | 2530 |
| Eif4a1 | 1522 | -3726 |
| Eif4a2 | 2507 | 3604 |
| Eif4b | 4639 | 677 |
| Eif4e | -1341 | -542 |
| Eif4ebp1 | 4612 | 3878 |
| Eif4g1 | 1298 | 1369 |
| Eif4h | 3551 | -2504 |
| Rps11 | 1663 | -3764 |
| Rps13 | 3015 | 2086 |
| Rps14 | 3836 | -2815 |
| Rps15a | 3088 | -125 |
| Rps16 | 4110 | -301 |
| Rps17 | 2325 | 319 |
| Rps18 | 3501 | -889 |
| Rps19 | 4264 | -190 |
| Rps20 | 3843 | -2669 |
| Rps21 | 3981 | -3337 |
| Rps23 | 4232 | -1084 |
| Rps24 | 4124 | -3163 |
| Rps25 | 4326 | -1875 |
| Rps26 | 3438 | -2966 |
| Rps27 | 4015 | -3368 |
| Rps27a | 2463 | 645 |
| Rps29 | 2286 | -2584 |
| Rps3 | 4276 | 1036 |
| Rps3a1 | 4505 | -891 |
| Rps4x | 4410 | -2262 |
| Rps5 | 4148 | 2414 |
| Rps6 | 3758 | -1321 |
| Rps7 | 3597 | -2184 |
| Rps8 | 2870 | -3674 |
| Rps9 | 4321 | -2721 |
| Rpsa | 4244 | 273 |
REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
| metric | value |
|---|---|
| setSize | 85 |
| pMANOVA | 2.9e-28 |
| p.adjustMANOVA | 6.7e-26 |
| s.dist | 0.68 |
| s.ctrl | 0.66 |
| s.Acss2KD | -0.164 |
| p.ctrl | 7.31e-26 |
| p.Acss2KD | 0.00906 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Eif3j2 | 2508 | -3837 |
| Rpl38 | 4075 | -2266 |
| Eif4h | 3551 | -2504 |
| Rpl36al | 4092 | -2051 |
| Rpl19 | 4402 | -1857 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Eif1ax | -807.0 | -1287.0 |
| Eif2s1 | -1448.0 | -2281.0 |
| Eif2s2 | 2496.0 | -1744.0 |
| Eif2s3x | 4435.0 | 2022.0 |
| Eif3a | 3552.0 | 739.0 |
| Eif3b | 3353.0 | -1965.0 |
| Eif3c | 3576.0 | -1138.0 |
| Eif3d | 3308.0 | -894.0 |
| Eif3e | 4230.0 | 3083.0 |
| Eif3f | 2064.0 | -2807.0 |
| Eif3g | 3427.0 | -1282.0 |
| Eif3h | 830.0 | 4152.0 |
| Eif3i | 3800.0 | -1632.0 |
| Eif3j2 | 2508.0 | -3837.0 |
| Eif3k | 2040.0 | 2530.0 |
| Eif4a1 | 1522.0 | -3726.0 |
| Eif4a2 | 2507.0 | 3604.0 |
| Eif4b | 4639.0 | 677.0 |
| Eif4e | -1341.0 | -542.0 |
| Eif4g1 | 1298.0 | 1369.0 |
| Eif4h | 3551.0 | -2504.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Uba52 | 1296.0 | 738.0 |
REACTOME_SIGNALING_BY_HIPPO
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 8.57e-05 |
| p.adjustMANOVA | 0.0018 |
| s.dist | 0.659 |
| s.ctrl | -0.147 |
| s.Acss2KD | -0.642 |
| p.ctrl | 0.326 |
| p.Acss2KD | 1.66e-05 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Wwtr1 | -4139 | -4594 |
| Amot | -4495 | -3893 |
| Sav1 | -3795 | -4464 |
| Yap1 | -3535 | -3912 |
| Tjp1 | -2864 | -4168 |
| Lats2 | -2363 | -2291 |
| Mob1b | -2834 | -1627 |
| Stk4 | -200 | -4323 |
| Amotl1 | -138 | -3634 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Amot | -4495 | -3893 |
| Amotl1 | -138 | -3634 |
| Amotl2 | 4096 | -1727 |
| Dvl2 | 1470 | -2998 |
| Lats1 | 104 | 1648 |
| Lats2 | -2363 | -2291 |
| Mob1a | 2939 | -2329 |
| Mob1b | -2834 | -1627 |
| Sav1 | -3795 | -4464 |
| Stk4 | -200 | -4323 |
| Tjp1 | -2864 | -4168 |
| Wwtr1 | -4139 | -4594 |
| Yap1 | -3535 | -3912 |
| Ywhab | 3629 | -2108 |
| Ywhae | 3085 | -4252 |
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
| metric | value |
|---|---|
| setSize | 73 |
| pMANOVA | 4.12e-21 |
| p.adjustMANOVA | 3.18e-19 |
| s.dist | 0.647 |
| s.ctrl | -0.646 |
| s.Acss2KD | 0.0254 |
| p.ctrl | 1.29e-21 |
| p.Acss2KD | 0.709 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Ndufb2 | -3309 | 3795 |
| Ndufb5 | -3877 | 3221 |
| Cycs | -4176 | 2966 |
| Cox6c | -4072 | 2901 |
| Ndufs8 | -3627 | 3195 |
| Ndufb10 | -3729 | 2967 |
| Etfa | -3966 | 2436 |
| Etfdh | -3947 | 2380 |
| Atp5c1 | -3225 | 2863 |
| Ndufs1 | -4168 | 2070 |
| Ndufa2 | -3099 | 2368 |
| Sdhb | -4362 | 1552 |
| Uqcrc2 | -3813 | 1706 |
| Ndufab1 | -3471 | 1855 |
| Ndufa9 | -3950 | 1597 |
| Ndufb4 | -3294 | 1551 |
| Ndufa5 | -3861 | 1274 |
| Ndufa4 | -3304 | 1436 |
| Ndufv2 | -2787 | 1647 |
| Uqcrq | -4320 | 1028 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Atp5a1 | -3393 | -325 |
| Atp5b | -3297 | 78 |
| Atp5c1 | -3225 | 2863 |
| Atp5d | -1717 | -1664 |
| Atp5e | -1772 | -595 |
| Atp5g1 | -4142 | 980 |
| Atp5h | -1884 | -1236 |
| Atp5j | -3639 | -1702 |
| Atp5j2 | -4065 | -2929 |
| Atp5k | -3446 | -425 |
| Atp5l | -3469 | -113 |
| Atp5o | -2838 | 1000 |
| Cox4i1 | -3891 | -613 |
| Cox5a | -3039 | -256 |
| Cox6a1 | 3247 | 3373 |
| Cox6b1 | -3845 | 258 |
| Cox6c | -4072 | 2901 |
| Cox7a2l | -2648 | -165 |
| Cox7c | -3797 | -1667 |
| Cox8a | 2222 | -2160 |
| Cyc1 | -4021 | -22 |
| Cycs | -4176 | 2966 |
| Etfa | -3966 | 2436 |
| Etfb | -3983 | -764 |
| Etfdh | -3947 | 2380 |
| Ndufa1 | -2755 | -2153 |
| Ndufa10 | -2708 | 790 |
| Ndufa11 | -4179 | -1782 |
| Ndufa12 | 103 | 1373 |
| Ndufa13 | -1962 | -3304 |
| Ndufa2 | -3099 | 2368 |
| Ndufa3 | -3455 | 762 |
| Ndufa4 | -3304 | 1436 |
| Ndufa5 | -3861 | 1274 |
| Ndufa6 | -3379 | 945 |
| Ndufa7 | -862 | -1839 |
| Ndufa8 | -3177 | 423 |
| Ndufa9 | -3950 | 1597 |
| Ndufab1 | -3471 | 1855 |
| Ndufb10 | -3729 | 2967 |
| Ndufb2 | -3309 | 3795 |
| Ndufb3 | -4374 | 322 |
| Ndufb4 | -3294 | 1551 |
| Ndufb5 | -3877 | 3221 |
| Ndufb6 | -3670 | -1929 |
| Ndufb7 | -3801 | -2700 |
| Ndufb9 | -3345 | -594 |
| Ndufc1 | -3299 | -137 |
| Ndufc2 | -1431 | -852 |
| Ndufs1 | -4168 | 2070 |
| Ndufs2 | -1622 | 2229 |
| Ndufs3 | -1691 | -1444 |
| Ndufs4 | -4022 | -743 |
| Ndufs5 | -2868 | -2028 |
| Ndufs6 | -4112 | -1253 |
| Ndufs7 | -2344 | -2877 |
| Ndufs8 | -3627 | 3195 |
| Ndufv1 | -4367 | -3206 |
| Ndufv2 | -2787 | 1647 |
| Ndufv3 | 36 | -2718 |
| Sdha | -3787 | -290 |
| Sdhb | -4362 | 1552 |
| Sdhc | -3581 | -767 |
| Sdhd | -3740 | 6 |
| Ucp2 | 4181 | -3064 |
| Ucp3 | 4548 | 3954 |
| Uqcr11 | -2210 | -3868 |
| Uqcrb | -3575 | -35 |
| Uqcrc1 | -4192 | -1083 |
| Uqcrc2 | -3813 | 1706 |
| Uqcrfs1 | -4017 | -240 |
| Uqcrh | -3064 | -975 |
| Uqcrq | -4320 | 1028 |
REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 1.08e-24 |
| p.adjustMANOVA | 1e-22 |
| s.dist | 0.622 |
| s.ctrl | 0.599 |
| s.Acss2KD | -0.166 |
| p.ctrl | 2.59e-22 |
| p.Acss2KD | 0.00727 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Sec11c | 3886 | -4502 |
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Rpl38 | 4075 | -2266 |
| Rpl36al | 4092 | -2051 |
| Rpl19 | 4402 | -1857 |
| Rps25 | 4326 | -1875 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Ddost | 1043.0 | -1045.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rpn1 | 3667.0 | 532.0 |
| Rpn2 | 3957.0 | -1569.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Sec11a | 977.0 | 502.0 |
| Sec11c | 3886.0 | -4502.0 |
| Sec61a1 | -1711.0 | 3339.0 |
| Sec61a2 | 583.0 | -180.0 |
| Sec61b | 1520.0 | -3616.0 |
| Sec61g | 613.0 | -1478.0 |
| Spcs1 | 1505.0 | 3097.0 |
| Spcs2 | 3923.0 | 1819.0 |
| Spcs3 | 600.0 | -1395.0 |
| Srp14 | -74.0 | -2322.0 |
| Srp19 | -1558.0 | 2614.0 |
| Srp54a | 850.0 | -702.0 |
| Srp68 | 1787.0 | -708.0 |
| Srp72 | 4312.0 | 516.0 |
| Srp9 | -507.0 | -3107.0 |
| Srprb | -280.0 | -2664.0 |
| Ssr1 | 3149.0 | 1189.0 |
| Ssr2 | 2453.0 | 788.0 |
| Ssr3 | 2025.0 | -2933.0 |
| Ssr4 | 4275.0 | 1292.0 |
| Tram1 | -2520.0 | 48.0 |
| Uba52 | 1296.0 | 738.0 |
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00151 |
| p.adjustMANOVA | 0.025 |
| s.dist | 0.593 |
| s.ctrl | -0.537 |
| s.Acss2KD | 0.252 |
| p.ctrl | 0.00204 |
| p.Acss2KD | 0.148 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Pdpr | -3949 | 3401 |
| Pdhb | -2870 | 3037 |
| Dld | -2931 | 2747 |
| Pdha1 | -3146 | 1714 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Dlat | -4402 | -1582 |
| Dld | -2931 | 2747 |
| Pdha1 | -3146 | 1714 |
| Pdhb | -2870 | 3037 |
| Pdhx | -3449 | -78 |
| Pdk1 | -4404 | -57 |
| Pdk2 | -3105 | -766 |
| Pdk4 | 3721 | 4210 |
| Pdp1 | -2614 | -4442 |
| Pdp2 | 748 | 4336 |
| Pdpr | -3949 | 3401 |
REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
| metric | value |
|---|---|
| setSize | 82 |
| pMANOVA | 5.39e-21 |
| p.adjustMANOVA | 3.56e-19 |
| s.dist | 0.592 |
| s.ctrl | 0.571 |
| s.Acss2KD | -0.159 |
| p.ctrl | 4.29e-19 |
| p.Acss2KD | 0.013 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Rpl38 | 4075 | -2266 |
| Rpl36al | 4092 | -2051 |
| Rpl19 | 4402 | -1857 |
| Rps25 | 4326 | -1875 |
| Rps7 | 3597 | -2184 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Dnajc3 | -237.0 | -1762.0 |
| Grsf1 | -115.0 | 2623.0 |
| Gtf2f1 | 4311.0 | -1183.0 |
| Gtf2f2 | 3129.0 | 256.0 |
| Hsp90aa1 | -3804.0 | 4242.0 |
| Ipo5 | 1577.0 | 2116.0 |
| Polr2a | 4239.0 | -873.0 |
| Polr2b | -343.0 | 2509.0 |
| Polr2c | 2894.0 | 616.0 |
| Polr2d | -602.0 | -1600.0 |
| Polr2e | -49.0 | 176.0 |
| Polr2f | -3736.0 | -3959.0 |
| Polr2g | 453.0 | 1638.0 |
| Polr2h | 1675.0 | -2060.0 |
| Polr2i | 719.0 | 1808.0 |
| Polr2j | -987.0 | -93.0 |
| Polr2k | -3021.0 | -3287.0 |
| Polr2l | 937.0 | -4440.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Uba52 | 1296.0 | 738.0 |
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
| metric | value |
|---|---|
| setSize | 107 |
| pMANOVA | 5.12e-26 |
| p.adjustMANOVA | 5.91e-24 |
| s.dist | 0.591 |
| s.ctrl | -0.588 |
| s.Acss2KD | 0.062 |
| p.ctrl | 8.74e-26 |
| p.Acss2KD | 0.269 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Slc16a1 | -3217 | 4488 |
| Pdpr | -3949 | 3401 |
| Ndufb2 | -3309 | 3795 |
| Ndufb5 | -3877 | 3221 |
| Cycs | -4176 | 2966 |
| Cox6c | -4072 | 2901 |
| Ndufs8 | -3627 | 3195 |
| Ndufb10 | -3729 | 2967 |
| Fh1 | -3688 | 2783 |
| Etfa | -3966 | 2436 |
| Etfdh | -3947 | 2380 |
| Atp5c1 | -3225 | 2863 |
| Idh3b | -3394 | 2629 |
| Ogdh | -3389 | 2604 |
| Pdhb | -2870 | 3037 |
| Ndufs1 | -4168 | 2070 |
| Dld | -2931 | 2747 |
| Ndufa2 | -3099 | 2368 |
| Sucla2 | -3523 | 1950 |
| Sdhb | -4362 | 1552 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Aco2 | -1645 | 1948 |
| Adhfe1 | 3212 | -1601 |
| Atp5a1 | -3393 | -325 |
| Atp5b | -3297 | 78 |
| Atp5c1 | -3225 | 2863 |
| Atp5d | -1717 | -1664 |
| Atp5e | -1772 | -595 |
| Atp5g1 | -4142 | 980 |
| Atp5h | -1884 | -1236 |
| Atp5j | -3639 | -1702 |
| Atp5j2 | -4065 | -2929 |
| Atp5k | -3446 | -425 |
| Atp5l | -3469 | -113 |
| Atp5o | -2838 | 1000 |
| Bsg | 4237 | 578 |
| Cox4i1 | -3891 | -613 |
| Cox5a | -3039 | -256 |
| Cox6a1 | 3247 | 3373 |
| Cox6b1 | -3845 | 258 |
| Cox6c | -4072 | 2901 |
| Cox7a2l | -2648 | -165 |
| Cox7c | -3797 | -1667 |
| Cox8a | 2222 | -2160 |
| Cs | -3381 | -821 |
| Cyc1 | -4021 | -22 |
| Cycs | -4176 | 2966 |
| D2hgdh | 2362 | -4378 |
| Dlat | -4402 | -1582 |
| Dld | -2931 | 2747 |
| Dlst | -3144 | 1623 |
| Etfa | -3966 | 2436 |
| Etfb | -3983 | -764 |
| Etfdh | -3947 | 2380 |
| Fh1 | -3688 | 2783 |
| Idh1 | 4346 | 4023 |
| Idh2 | -4392 | -344 |
| Idh3a | -3237 | 509 |
| Idh3b | -3394 | 2629 |
| Idh3g | -3533 | 173 |
| L2hgdh | -4284 | -2139 |
| Ldha | 3361 | -1615 |
| Ldhb | -4338 | 1221 |
| Mdh2 | -4028 | -1792 |
| Ndufa1 | -2755 | -2153 |
| Ndufa10 | -2708 | 790 |
| Ndufa11 | -4179 | -1782 |
| Ndufa12 | 103 | 1373 |
| Ndufa13 | -1962 | -3304 |
| Ndufa2 | -3099 | 2368 |
| Ndufa3 | -3455 | 762 |
| Ndufa4 | -3304 | 1436 |
| Ndufa5 | -3861 | 1274 |
| Ndufa6 | -3379 | 945 |
| Ndufa7 | -862 | -1839 |
| Ndufa8 | -3177 | 423 |
| Ndufa9 | -3950 | 1597 |
| Ndufab1 | -3471 | 1855 |
| Ndufb10 | -3729 | 2967 |
| Ndufb2 | -3309 | 3795 |
| Ndufb3 | -4374 | 322 |
| Ndufb4 | -3294 | 1551 |
| Ndufb5 | -3877 | 3221 |
| Ndufb6 | -3670 | -1929 |
| Ndufb7 | -3801 | -2700 |
| Ndufb9 | -3345 | -594 |
| Ndufc1 | -3299 | -137 |
| Ndufc2 | -1431 | -852 |
| Ndufs1 | -4168 | 2070 |
| Ndufs2 | -1622 | 2229 |
| Ndufs3 | -1691 | -1444 |
| Ndufs4 | -4022 | -743 |
| Ndufs5 | -2868 | -2028 |
| Ndufs6 | -4112 | -1253 |
| Ndufs7 | -2344 | -2877 |
| Ndufs8 | -3627 | 3195 |
| Ndufv1 | -4367 | -3206 |
| Ndufv2 | -2787 | 1647 |
| Ndufv3 | 36 | -2718 |
| Nnt | -4248 | 797 |
| Ogdh | -3389 | 2604 |
| Pdha1 | -3146 | 1714 |
| Pdhb | -2870 | 3037 |
| Pdhx | -3449 | -78 |
| Pdk1 | -4404 | -57 |
| Pdk2 | -3105 | -766 |
| Pdk4 | 3721 | 4210 |
| Pdp1 | -2614 | -4442 |
| Pdp2 | 748 | 4336 |
| Pdpr | -3949 | 3401 |
| Sdha | -3787 | -290 |
| Sdhb | -4362 | 1552 |
| Sdhc | -3581 | -767 |
| Sdhd | -3740 | 6 |
| Slc16a1 | -3217 | 4488 |
| Slc16a3 | 1223 | -1989 |
| Sucla2 | -3523 | 1950 |
| Suclg1 | -3852 | 1041 |
| Suclg2 | -3306 | -3226 |
| Ucp2 | 4181 | -3064 |
| Ucp3 | 4548 | 3954 |
| Uqcr11 | -2210 | -3868 |
| Uqcrb | -3575 | -35 |
| Uqcrc1 | -4192 | -1083 |
| Uqcrc2 | -3813 | 1706 |
| Uqcrfs1 | -4017 | -240 |
| Uqcrh | -3064 | -975 |
| Uqcrq | -4320 | 1028 |
REACTOME_TRANSLATION
| metric | value |
|---|---|
| setSize | 123 |
| pMANOVA | 5.64e-30 |
| p.adjustMANOVA | 2.6e-27 |
| s.dist | 0.586 |
| s.ctrl | 0.573 |
| s.Acss2KD | -0.123 |
| p.ctrl | 6.07e-28 |
| p.Acss2KD | 0.0189 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Sec11c | 3886 | -4502 |
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Eif3j2 | 2508 | -3837 |
| Rpl38 | 4075 | -2266 |
| Eif4h | 3551 | -2504 |
| Rpl36al | 4092 | -2051 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Ddost | 1043.0 | -1045.0 |
| Eef1a1 | 3477.0 | -2105.0 |
| Eef1b2 | 3186.0 | -1116.0 |
| Eef1d | 2715.0 | 3853.0 |
| Eef1g | 4598.0 | 2855.0 |
| Eef2 | 4494.0 | -509.0 |
| Eif1ax | -807.0 | -1287.0 |
| Eif2b1 | -743.0 | -1187.0 |
| Eif2b2 | 2577.0 | -994.0 |
| Eif2b3 | 4628.0 | 700.0 |
| Eif2b4 | 1005.0 | 203.0 |
| Eif2b5 | -2654.0 | -3675.0 |
| Eif2s1 | -1448.0 | -2281.0 |
| Eif2s2 | 2496.0 | -1744.0 |
| Eif2s3x | 4435.0 | 2022.0 |
| Eif3a | 3552.0 | 739.0 |
| Eif3b | 3353.0 | -1965.0 |
| Eif3c | 3576.0 | -1138.0 |
| Eif3d | 3308.0 | -894.0 |
| Eif3e | 4230.0 | 3083.0 |
| Eif3f | 2064.0 | -2807.0 |
| Eif3g | 3427.0 | -1282.0 |
| Eif3h | 830.0 | 4152.0 |
| Eif3i | 3800.0 | -1632.0 |
| Eif3j2 | 2508.0 | -3837.0 |
| Eif3k | 2040.0 | 2530.0 |
| Eif4a1 | 1522.0 | -3726.0 |
| Eif4a2 | 2507.0 | 3604.0 |
| Eif4b | 4639.0 | 677.0 |
| Eif4e | -1341.0 | -542.0 |
| Eif4ebp1 | 4612.0 | 3878.0 |
| Eif4g1 | 1298.0 | 1369.0 |
| Eif4h | 3551.0 | -2504.0 |
| Eif5 | 3578.0 | 2448.0 |
| Eif5b | 896.0 | -2260.0 |
| Etf1 | 60.0 | 2429.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rpn1 | 3667.0 | 532.0 |
| Rpn2 | 3957.0 | -1569.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Sec11a | 977.0 | 502.0 |
| Sec11c | 3886.0 | -4502.0 |
| Sec61a1 | -1711.0 | 3339.0 |
| Sec61a2 | 583.0 | -180.0 |
| Sec61b | 1520.0 | -3616.0 |
| Sec61g | 613.0 | -1478.0 |
| Spcs1 | 1505.0 | 3097.0 |
| Spcs2 | 3923.0 | 1819.0 |
| Spcs3 | 600.0 | -1395.0 |
| Srp14 | -74.0 | -2322.0 |
| Srp19 | -1558.0 | 2614.0 |
| Srp54a | 850.0 | -702.0 |
| Srp68 | 1787.0 | -708.0 |
| Srp72 | 4312.0 | 516.0 |
| Srp9 | -507.0 | -3107.0 |
| Srprb | -280.0 | -2664.0 |
| Ssr1 | 3149.0 | 1189.0 |
| Ssr2 | 2453.0 | 788.0 |
| Ssr3 | 2025.0 | -2933.0 |
| Ssr4 | 4275.0 | 1292.0 |
| Tram1 | -2520.0 | 48.0 |
| Uba52 | 1296.0 | 738.0 |
REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00425 |
| p.adjustMANOVA | 0.0578 |
| s.dist | 0.548 |
| s.ctrl | 0.516 |
| s.Acss2KD | -0.187 |
| p.ctrl | 0.00307 |
| p.Acss2KD | 0.284 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Pygb | 3960 | -3020 |
| Pgm1 | 2575 | -2856 |
| Phkg1 | 2402 | -2475 |
| Calm1 | 2353 | -2149 |
| Pygm | 3970 | -1118 |
| Phkb | 3330 | -1074 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Agl | -1256 | -3066 |
| Calm1 | 2353 | -2149 |
| Gyg | 3468 | 2121 |
| Pgm1 | 2575 | -2856 |
| Phka1 | 3464 | 1039 |
| Phka2 | 907 | 2 |
| Phkb | 3330 | -1074 |
| Phkg1 | 2402 | -2475 |
| Phkg2 | 1727 | 2895 |
| Pygb | 3960 | -3020 |
| Pygm | 3970 | -1118 |
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
| metric | value |
|---|---|
| setSize | 84 |
| pMANOVA | 2.9e-18 |
| p.adjustMANOVA | 1.49e-16 |
| s.dist | 0.547 |
| s.ctrl | 0.531 |
| s.Acss2KD | -0.128 |
| p.ctrl | 3.98e-17 |
| p.Acss2KD | 0.0423 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Rpl38 | 4075 | -2266 |
| Rpl36al | 4092 | -2051 |
| Rpl19 | 4402 | -1857 |
| Rps25 | 4326 | -1875 |
| Rps7 | 3597 | -2184 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Casc3 | 3280.0 | -834.0 |
| Eif4a3 | 1243.0 | -4264.0 |
| Eif4g1 | 1298.0 | 1369.0 |
| Etf1 | 60.0 | 2429.0 |
| Magoh | -1006.0 | -1392.0 |
| Ncbp1 | -949.0 | 421.0 |
| Ncbp2 | -146.0 | -2230.0 |
| Ppp2ca | 2167.0 | 4308.0 |
| Ppp2r1a | -1610.0 | -4003.0 |
| Ppp2r2a | -2629.0 | -1140.0 |
| Rnps1 | 2649.0 | 1465.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Smg1 | -1326.0 | 4125.0 |
| Smg5 | 15.0 | -2620.0 |
| Smg6 | -2624.0 | -3351.0 |
| Smg7 | -487.0 | 2650.0 |
| Smg8 | -2219.0 | 3854.0 |
| Smg9 | 654.0 | 1772.0 |
| Uba52 | 1296.0 | 738.0 |
| Upf2 | 523.0 | 910.0 |
| Upf3a | -353.0 | -150.0 |
| Upf3b | -1234.0 | 3676.0 |
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
| metric | value |
|---|---|
| setSize | 38 |
| pMANOVA | 1e-07 |
| p.adjustMANOVA | 2.44e-06 |
| s.dist | 0.512 |
| s.ctrl | -0.496 |
| s.Acss2KD | 0.128 |
| p.ctrl | 1.25e-07 |
| p.Acss2KD | 0.172 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Slc16a1 | -3217 | 4488 |
| Pdpr | -3949 | 3401 |
| Fh1 | -3688 | 2783 |
| Idh3b | -3394 | 2629 |
| Ogdh | -3389 | 2604 |
| Pdhb | -2870 | 3037 |
| Dld | -2931 | 2747 |
| Sucla2 | -3523 | 1950 |
| Sdhb | -4362 | 1552 |
| Pdha1 | -3146 | 1714 |
| Ldhb | -4338 | 1221 |
| Dlst | -3144 | 1623 |
| Suclg1 | -3852 | 1041 |
| Nnt | -4248 | 797 |
| Aco2 | -1645 | 1948 |
| Idh3a | -3237 | 509 |
| Idh3g | -3533 | 173 |
| Sdhd | -3740 | 6 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Aco2 | -1645 | 1948 |
| Adhfe1 | 3212 | -1601 |
| Bsg | 4237 | 578 |
| Cs | -3381 | -821 |
| D2hgdh | 2362 | -4378 |
| Dlat | -4402 | -1582 |
| Dld | -2931 | 2747 |
| Dlst | -3144 | 1623 |
| Fh1 | -3688 | 2783 |
| Idh1 | 4346 | 4023 |
| Idh2 | -4392 | -344 |
| Idh3a | -3237 | 509 |
| Idh3b | -3394 | 2629 |
| Idh3g | -3533 | 173 |
| L2hgdh | -4284 | -2139 |
| Ldha | 3361 | -1615 |
| Ldhb | -4338 | 1221 |
| Mdh2 | -4028 | -1792 |
| Nnt | -4248 | 797 |
| Ogdh | -3389 | 2604 |
| Pdha1 | -3146 | 1714 |
| Pdhb | -2870 | 3037 |
| Pdhx | -3449 | -78 |
| Pdk1 | -4404 | -57 |
| Pdk2 | -3105 | -766 |
| Pdk4 | 3721 | 4210 |
| Pdp1 | -2614 | -4442 |
| Pdp2 | 748 | 4336 |
| Pdpr | -3949 | 3401 |
| Sdha | -3787 | -290 |
| Sdhb | -4362 | 1552 |
| Sdhc | -3581 | -767 |
| Sdhd | -3740 | 6 |
| Slc16a1 | -3217 | 4488 |
| Slc16a3 | 1223 | -1989 |
| Sucla2 | -3523 | 1950 |
| Suclg1 | -3852 | 1041 |
| Suclg2 | -3306 | -3226 |
REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0193 |
| p.adjustMANOVA | 0.184 |
| s.dist | 0.483 |
| s.ctrl | -0.0157 |
| s.Acss2KD | 0.483 |
| p.ctrl | 0.928 |
| p.Acss2KD | 0.00554 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Hsp90b1 | -1354 | 4410 |
| Ddit3 | -1670 | 2698 |
| Atf6 | -452 | 2828 |
| Mbtps1 | -3005 | 202 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Atf4 | 1613 | 2918 |
| Atf6 | -452 | 2828 |
| Calr | 2185 | 1643 |
| Ddit3 | -1670 | 2698 |
| Hsp90b1 | -1354 | 4410 |
| Hspa5 | 1069 | 3809 |
| Mbtps1 | -3005 | 202 |
| Mbtps2 | 143 | 1315 |
| Nfya | 2642 | 1126 |
| Nfyb | -3366 | -387 |
| Xbp1 | 2192 | 3646 |
REACTOME_INFLUENZA_LIFE_CYCLE
| metric | value |
|---|---|
| setSize | 113 |
| pMANOVA | 6.91e-16 |
| p.adjustMANOVA | 2.9e-14 |
| s.dist | 0.444 |
| s.ctrl | 0.44 |
| s.Acss2KD | -0.0627 |
| p.ctrl | 7.87e-16 |
| p.Acss2KD | 0.251 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Rpl12 | 4392 | -3547 |
| Rpl3 | 3866 | -3717 |
| Rpl24 | 4331 | -3236 |
| Rps27 | 4015 | -3368 |
| Seh1l | 3268 | -4127 |
| Rps21 | 3981 | -3337 |
| Rps24 | 4124 | -3163 |
| Rpl15 | 4431 | -2834 |
| Rps9 | 4321 | -2721 |
| Rpl37 | 3604 | -3055 |
| Rps14 | 3836 | -2815 |
| Rplp0 | 4529 | -2375 |
| Rps8 | 2870 | -3674 |
| Rps20 | 3843 | -2669 |
| Rps26 | 3438 | -2966 |
| Rps4x | 4410 | -2262 |
| Ran | 3924 | -2537 |
| Rpl38 | 4075 | -2266 |
| Rpl36al | 4092 | -2051 |
| Rpl19 | 4402 | -1857 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Aaas | 2061.0 | -2934.0 |
| Calr | 2185.0 | 1643.0 |
| Canx | 1622.0 | -1466.0 |
| Clta | 3021.0 | 1858.0 |
| Cltc | 3453.0 | 4563.0 |
| Dnajc3 | -237.0 | -1762.0 |
| Grsf1 | -115.0 | 2623.0 |
| Gtf2f1 | 4311.0 | -1183.0 |
| Gtf2f2 | 3129.0 | 256.0 |
| Hsp90aa1 | -3804.0 | 4242.0 |
| Hspa1b | -3953.0 | 4323.0 |
| Ipo5 | 1577.0 | 2116.0 |
| Kpna1 | 1171.0 | 397.0 |
| Kpnb1 | 1586.0 | -461.0 |
| Nup107 | 1574.0 | -2485.0 |
| Nup133 | 388.0 | 3332.0 |
| Nup153 | 2661.0 | 2185.0 |
| Nup155 | 3328.0 | -1449.0 |
| Nup188 | 487.0 | 2122.0 |
| Nup205 | 1370.0 | -1113.0 |
| Nup210 | -2413.0 | 2428.0 |
| Nup214 | -1323.0 | 842.0 |
| Nup35 | -687.0 | 2336.0 |
| Nup37 | -3030.0 | -73.0 |
| Nup54 | -4131.0 | 1644.0 |
| Nup62 | -1426.0 | 606.0 |
| Nup85 | 2096.0 | 1671.0 |
| Nup88 | 1960.0 | 558.0 |
| Nup93 | -82.0 | 1079.0 |
| Nupl2 | -2859.0 | 4306.0 |
| Polr2a | 4239.0 | -873.0 |
| Polr2b | -343.0 | 2509.0 |
| Polr2c | 2894.0 | 616.0 |
| Polr2d | -602.0 | -1600.0 |
| Polr2e | -49.0 | 176.0 |
| Polr2f | -3736.0 | -3959.0 |
| Polr2g | 453.0 | 1638.0 |
| Polr2h | 1675.0 | -2060.0 |
| Polr2i | 719.0 | 1808.0 |
| Polr2j | -987.0 | -93.0 |
| Polr2k | -3021.0 | -3287.0 |
| Polr2l | 937.0 | -4440.0 |
| Pom121 | -1871.0 | 2474.0 |
| Rae1 | -646.0 | -1389.0 |
| Ran | 3924.0 | -2537.0 |
| Ranbp2 | 1394.0 | 3575.0 |
| Rpl10a | 4258.0 | 851.0 |
| Rpl11 | 737.0 | -1926.0 |
| Rpl12 | 4392.0 | -3547.0 |
| Rpl13 | 4151.0 | -1595.0 |
| Rpl14 | 4588.0 | 855.0 |
| Rpl15 | 4431.0 | -2834.0 |
| Rpl18 | 3698.0 | 519.0 |
| Rpl18a | 3607.0 | -90.0 |
| Rpl19 | 4402.0 | -1857.0 |
| Rpl22 | 3078.0 | 3314.0 |
| Rpl23 | 3362.0 | -795.0 |
| Rpl23a | 3841.0 | -128.0 |
| Rpl24 | 4331.0 | -3236.0 |
| Rpl26 | 3889.0 | 1110.0 |
| Rpl27-ps3 | 585.5 | 99.5 |
| Rpl27a | 3575.0 | -313.0 |
| Rpl28 | 3277.0 | 1701.0 |
| Rpl29 | 1615.0 | -3034.0 |
| Rpl3 | 3866.0 | -3717.0 |
| Rpl30 | 2876.0 | 2153.0 |
| Rpl32 | 4061.0 | 763.0 |
| Rpl34 | 795.0 | -347.0 |
| Rpl35 | 3867.0 | 1099.0 |
| Rpl36al | 4092.0 | -2051.0 |
| Rpl37 | 3604.0 | -3055.0 |
| Rpl37a | 1549.0 | -739.0 |
| Rpl38 | 4075.0 | -2266.0 |
| Rpl39 | 621.0 | 91.0 |
| Rpl3l | -1527.0 | 503.0 |
| Rpl4 | 4583.0 | 2126.0 |
| Rpl41 | 3258.0 | 118.0 |
| Rpl5 | 2477.0 | -274.0 |
| Rpl6 | 4449.0 | 583.0 |
| Rpl8 | 4498.0 | -1411.0 |
| Rplp0 | 4529.0 | -2375.0 |
| Rplp1 | 774.0 | -1520.0 |
| Rplp2 | 2412.0 | -2316.0 |
| Rps11 | 1663.0 | -3764.0 |
| Rps13 | 3015.0 | 2086.0 |
| Rps14 | 3836.0 | -2815.0 |
| Rps15a | 3088.0 | -125.0 |
| Rps16 | 4110.0 | -301.0 |
| Rps17 | 2325.0 | 319.0 |
| Rps18 | 3501.0 | -889.0 |
| Rps19 | 4264.0 | -190.0 |
| Rps20 | 3843.0 | -2669.0 |
| Rps21 | 3981.0 | -3337.0 |
| Rps23 | 4232.0 | -1084.0 |
| Rps24 | 4124.0 | -3163.0 |
| Rps25 | 4326.0 | -1875.0 |
| Rps26 | 3438.0 | -2966.0 |
| Rps27 | 4015.0 | -3368.0 |
| Rps27a | 2463.0 | 645.0 |
| Rps29 | 2286.0 | -2584.0 |
| Rps3 | 4276.0 | 1036.0 |
| Rps3a1 | 4505.0 | -891.0 |
| Rps4x | 4410.0 | -2262.0 |
| Rps5 | 4148.0 | 2414.0 |
| Rps6 | 3758.0 | -1321.0 |
| Rps7 | 3597.0 | -2184.0 |
| Rps8 | 2870.0 | -3674.0 |
| Rps9 | 4321.0 | -2721.0 |
| Rpsa | 4244.0 | 273.0 |
| Seh1l | 3268.0 | -4127.0 |
| Tpr | 1909.0 | 2246.0 |
| Uba52 | 1296.0 | 738.0 |
| Xpo1 | -2462.0 | 489.0 |
REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0621 |
| p.adjustMANOVA | 0.319 |
| s.dist | 0.436 |
| s.ctrl | 0.274 |
| s.Acss2KD | 0.338 |
| p.ctrl | 0.115 |
| p.Acss2KD | 0.052 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Adss | 4621 | 4520 |
| Pfas | 2845 | 4349 |
| Atic | 2122 | 3399 |
| Impdh2 | 2993 | 1872 |
| Adssl1 | 540 | 2058 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Adsl | -3562 | -773 |
| Adss | 4621 | 4520 |
| Adssl1 | 540 | 2058 |
| Atic | 2122 | 3399 |
| Gart | -1906 | 2817 |
| Gmps | -1443 | 3981 |
| Impdh1 | 2570 | -1117 |
| Impdh2 | 2993 | 1872 |
| Paics | 3725 | -1432 |
| Pfas | 2845 | 4349 |
| Ppat | 2179 | -2788 |
REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0465 |
| p.adjustMANOVA | 0.276 |
| s.dist | 0.422 |
| s.ctrl | 0.277 |
| s.Acss2KD | 0.318 |
| p.ctrl | 0.0838 |
| p.Acss2KD | 0.0474 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Nfkbia | 4394 | 4408 |
| Ikbkg | 3459 | 3324 |
| Traf2 | 3737 | 1474 |
| Chuk | 1289 | 3808 |
| Map3k1 | 2354 | 592 |
| Rela | 394 | 2267 |
| Nfkb2 | 217 | 42 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| App | -2809 | 1169 |
| Chuk | 1289 | 3808 |
| Ikbkb | 3471 | -2751 |
| Ikbkg | 3459 | 3324 |
| Map3k1 | 2354 | 592 |
| Mavs | -3712 | 3968 |
| Nfkb2 | 217 | 42 |
| Nfkbia | 4394 | 4408 |
| Nfkbib | 4397 | -670 |
| Rela | 394 | 2267 |
| Traf2 | 3737 | 1474 |
| Traf6 | -363 | 1778 |
| Trim25 | 684 | -697 |
REACTOME_EXTENSION_OF_TELOMERES
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0206 |
| p.adjustMANOVA | 0.186 |
| s.dist | 0.418 |
| s.ctrl | 0.348 |
| s.Acss2KD | -0.232 |
| p.ctrl | 0.0298 |
| p.Acss2KD | 0.148 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Dkc1 | 4115 | -2679 |
| Rfc4 | 4138 | -2571 |
| Pold4 | 3433 | -2977 |
| Ruvbl1 | 1492 | -4110 |
| Nhp2 | 286 | -4106 |
| Rpa2 | 1748 | -227 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Dkc1 | 4115 | -2679 |
| Nhp2 | 286 | -4106 |
| Pcna | 3132 | 1051 |
| Pola2 | -3521 | 185 |
| Pold1 | 4589 | 2979 |
| Pold2 | -2657 | 70 |
| Pold4 | 3433 | -2977 |
| Rfc2 | 3242 | 872 |
| Rfc4 | 4138 | -2571 |
| Rpa1 | 4199 | 1131 |
| Rpa2 | 1748 | -227 |
| Ruvbl1 | 1492 | -4110 |
| Ruvbl2 | -2426 | -3798 |
REACTOME_PYRUVATE_METABOLISM
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0093 |
| p.adjustMANOVA | 0.116 |
| s.dist | 0.415 |
| s.ctrl | -0.357 |
| s.Acss2KD | 0.212 |
| p.ctrl | 0.0134 |
| p.Acss2KD | 0.143 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Slc16a1 | -3217 | 4488 |
| Pdpr | -3949 | 3401 |
| Pdhb | -2870 | 3037 |
| Dld | -2931 | 2747 |
| Pdha1 | -3146 | 1714 |
| Ldhb | -4338 | 1221 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Bsg | 4237 | 578 |
| Dlat | -4402 | -1582 |
| Dld | -2931 | 2747 |
| Ldha | 3361 | -1615 |
| Ldhb | -4338 | 1221 |
| Pdha1 | -3146 | 1714 |
| Pdhb | -2870 | 3037 |
| Pdhx | -3449 | -78 |
| Pdk1 | -4404 | -57 |
| Pdk2 | -3105 | -766 |
| Pdk4 | 3721 | 4210 |
| Pdp1 | -2614 | -4442 |
| Pdp2 | 748 | 4336 |
| Pdpr | -3949 | 3401 |
| Slc16a1 | -3217 | 4488 |
| Slc16a3 | 1223 | -1989 |
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0241 |
| p.adjustMANOVA | 0.197 |
| s.dist | 0.41 |
| s.ctrl | 0.342 |
| s.Acss2KD | -0.226 |
| p.ctrl | 0.0329 |
| p.Acss2KD | 0.158 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Map2k2 | 3542 | -4337 |
| Map2k1 | 2978 | -3334 |
| Shc1 | 2888 | -3311 |
| Ywhab | 3629 | -2108 |
| Grb2 | 2454 | -474 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Grb2 | 2454 | -474 |
| Hbegf | 4553 | 4543 |
| Hras | -248 | -3984 |
| Kras | -3480 | -453 |
| Map2k1 | 2978 | -3334 |
| Map2k2 | 3542 | -4337 |
| Mapk1 | 1017 | 639 |
| Mapk3 | 1658 | 1988 |
| Nras | -1199 | -2227 |
| Raf1 | -20 | -1469 |
| Shc1 | 2888 | -3311 |
| Sos1 | 3617 | 689 |
| Ywhab | 3629 | -2108 |
REACTOME_SHC_MEDIATED_SIGNALLING
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0244 |
| p.adjustMANOVA | 0.197 |
| s.dist | 0.409 |
| s.ctrl | 0.337 |
| s.Acss2KD | -0.232 |
| p.ctrl | 0.0357 |
| p.Acss2KD | 0.147 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Map2k2 | 3542 | -4337 |
| Map2k1 | 2978 | -3334 |
| Shc1 | 2888 | -3311 |
| Ywhab | 3629 | -2108 |
| Grb2 | 2454 | -474 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Grb2 | 2454 | -474 |
| Hras | -248 | -3984 |
| Kras | -3480 | -453 |
| Map2k1 | 2978 | -3334 |
| Map2k2 | 3542 | -4337 |
| Mapk1 | 1017 | 639 |
| Mapk3 | 1658 | 1988 |
| Nras | -1199 | -2227 |
| Raf1 | -20 | -1469 |
| Shc1 | 2888 | -3311 |
| Shc2 | 4235 | 4183 |
| Sos1 | 3617 | 689 |
| Ywhab | 3629 | -2108 |
REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.116 |
| p.adjustMANOVA | 0.424 |
| s.dist | 0.402 |
| s.ctrl | -0.32 |
| s.Acss2KD | -0.244 |
| p.ctrl | 0.0802 |
| p.Acss2KD | 0.181 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| B4galt5 | -4290 | -4293 |
| St3gal1 | -4016 | -3710 |
| Galnt10 | -2092 | -4490 |
| St3gal3 | -2132 | -2725 |
| Galnt1 | -1984 | -1967 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| B4galt5 | -4290 | -4293 |
| C1galt1 | -2299 | 259 |
| C1galt1c1 | 2738 | -173 |
| Galnt1 | -1984 | -1967 |
| Galnt10 | -2092 | -4490 |
| Galnt11 | -663 | 3160 |
| St3gal1 | -4016 | -3710 |
| St3gal2 | 4373 | 1719 |
| St3gal3 | -2132 | -2725 |
| St6galnac4 | -3626 | 745 |
REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.02 |
| p.adjustMANOVA | 0.184 |
| s.dist | 0.392 |
| s.ctrl | 0.199 |
| s.Acss2KD | -0.338 |
| p.ctrl | 0.182 |
| p.Acss2KD | 0.0235 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Anapc4 | 3163 | -3834 |
| Ube2e1 | 4546 | -2044 |
| Bub3 | 3562 | -1342 |
| Anapc2 | 1956 | -2124 |
| Anapc5 | 3342 | -1132 |
| Anapc11 | 718 | -2850 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Anapc1 | 3012 | 1579 |
| Anapc10 | 665 | 318 |
| Anapc11 | 718 | -2850 |
| Anapc2 | 1956 | -2124 |
| Anapc4 | 3163 | -3834 |
| Anapc5 | 3342 | -1132 |
| Anapc7 | -277 | -1218 |
| Bub3 | 3562 | -1342 |
| Cdc16 | -3530 | 586 |
| Cdc23 | -2917 | -4053 |
| Cdc26 | -992 | -2007 |
| Cdc27 | -2236 | -2032 |
| Ube2c | 3977 | 492 |
| Ube2d1 | -163 | -4001 |
| Ube2e1 | 4546 | -2044 |
REACTOME_METABOLISM_OF_POLYAMINES
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.081 |
| p.adjustMANOVA | 0.363 |
| s.dist | 0.391 |
| s.ctrl | 0.354 |
| s.Acss2KD | 0.164 |
| p.ctrl | 0.0336 |
| p.Acss2KD | 0.325 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Sms | 4491 | 4114 |
| Odc1 | 4597 | 3477 |
| Sat1 | 3846 | 3158 |
| Srm | 3067 | 1982 |
| Enoph1 | 550 | 2097 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Adi1 | 4183 | -3579 |
| Amd1 | 151 | -4576 |
| Apip | -635 | -974 |
| Enoph1 | 550 | 2097 |
| Got1 | -4127 | 4055 |
| Mri1 | -165 | 2852 |
| Mtap | 2716 | -3083 |
| Odc1 | 4597 | 3477 |
| Sat1 | 3846 | 3158 |
| Smox | 1766 | -738 |
| Sms | 4491 | 4114 |
| Srm | 3067 | 1982 |
REACTOME_DNA_STRAND_ELONGATION
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0704 |
| p.adjustMANOVA | 0.336 |
| s.dist | 0.39 |
| s.ctrl | 0.384 |
| s.Acss2KD | 0.0721 |
| p.ctrl | 0.0215 |
| p.Acss2KD | 0.666 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Pold1 | 4589 | 2979 |
| Rpa1 | 4199 | 1131 |
| Pcna | 3132 | 1051 |
| Rfc2 | 3242 | 872 |
| Mcm2 | 3829 | 490 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Gins4 | -2982 | 2940 |
| Mcm2 | 3829 | 490 |
| Mcm7 | 2895 | -237 |
| Pcna | 3132 | 1051 |
| Pola2 | -3521 | 185 |
| Pold1 | 4589 | 2979 |
| Pold2 | -2657 | 70 |
| Pold4 | 3433 | -2977 |
| Rfc2 | 3242 | 872 |
| Rfc4 | 4138 | -2571 |
| Rpa1 | 4199 | 1131 |
| Rpa2 | 1748 | -227 |
REACTOME_PHOSPHORYLATION_OF_THE_APC_C
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0358 |
| p.adjustMANOVA | 0.239 |
| s.dist | 0.377 |
| s.ctrl | 0.159 |
| s.Acss2KD | -0.341 |
| p.ctrl | 0.303 |
| p.Acss2KD | 0.027 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Anapc4 | 3163 | -3834 |
| Ube2e1 | 4546 | -2044 |
| Anapc2 | 1956 | -2124 |
| Anapc5 | 3342 | -1132 |
| Anapc11 | 718 | -2850 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Anapc1 | 3012 | 1579 |
| Anapc10 | 665 | 318 |
| Anapc11 | 718 | -2850 |
| Anapc2 | 1956 | -2124 |
| Anapc4 | 3163 | -3834 |
| Anapc5 | 3342 | -1132 |
| Anapc7 | -277 | -1218 |
| Cdc16 | -3530 | 586 |
| Cdc23 | -2917 | -4053 |
| Cdc26 | -992 | -2007 |
| Cdc27 | -2236 | -2032 |
| Ube2c | 3977 | 492 |
| Ube2d1 | -163 | -4001 |
| Ube2e1 | 4546 | -2044 |
REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0717 |
| p.adjustMANOVA | 0.337 |
| s.dist | 0.377 |
| s.ctrl | -0.281 |
| s.Acss2KD | -0.251 |
| p.ctrl | 0.0686 |
| p.Acss2KD | 0.105 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Ppp2r5e | -3584 | -3626 |
| Ppp2r5b | -3191 | -2773 |
| Ppp2r1a | -1610 | -4003 |
| Frat2 | -2346 | -2728 |
| Ppp2r5a | -1142 | -3165 |
| Ppp2r5d | -3494 | -528 |
| Ppp2cb | -971 | -1129 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Apc | -3157 | 950 |
| Axin1 | 230 | -2739 |
| Csnk1a1 | -292 | 933 |
| Ctnnb1 | -1916 | 593 |
| Frat2 | -2346 | -2728 |
| Ppp2ca | 2167 | 4308 |
| Ppp2cb | -971 | -1129 |
| Ppp2r1a | -1610 | -4003 |
| Ppp2r1b | 4296 | -3027 |
| Ppp2r5a | -1142 | -3165 |
| Ppp2r5b | -3191 | -2773 |
| Ppp2r5c | -2097 | 473 |
| Ppp2r5d | -3494 | -528 |
| Ppp2r5e | -3584 | -3626 |
REACTOME_COLLAGEN_FORMATION
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 0.00268 |
| p.adjustMANOVA | 0.0395 |
| s.dist | 0.374 |
| s.ctrl | -0.106 |
| s.Acss2KD | 0.358 |
| p.ctrl | 0.348 |
| p.Acss2KD | 0.00157 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Col6a1 | -4250 | 2642 |
| Col22a1 | -3149 | 3506 |
| Col6a3 | -2636 | 3439 |
| Col4a1 | -1740 | 4372 |
| Bmp1 | -1687 | 3717 |
| Serpinh1 | -816 | 4009 |
| Col6a2 | -3653 | 832 |
| Col5a2 | -648 | 3204 |
| Pcolce | -543 | 2233 |
| Col4a2 | -246 | 4244 |
| Pcolce2 | -227 | 2965 |
| Plod1 | -56 | 2798 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Adamts2 | 3671 | 3048 |
| Bmp1 | -1687 | 3717 |
| Col11a2 | -1863 | -3081 |
| Col14a1 | 1819 | 4380 |
| Col15a1 | 225 | 1997 |
| Col1a1 | 1664 | 2200 |
| Col1a2 | 1968 | 2611 |
| Col22a1 | -3149 | 3506 |
| Col24a1 | -1845 | -24 |
| Col3a1 | 194 | 556 |
| Col4a1 | -1740 | 4372 |
| Col4a2 | -246 | 4244 |
| Col5a1 | 328 | 486 |
| Col5a2 | -648 | 3204 |
| Col5a3 | -1123 | -2247 |
| Col6a1 | -4250 | 2642 |
| Col6a2 | -3653 | 832 |
| Col6a3 | -2636 | 3439 |
| Col7a1 | 3757 | -1509 |
| P4hb | 250 | 142 |
| Pcolce | -543 | 2233 |
| Pcolce2 | -227 | 2965 |
| Plod1 | -56 | 2798 |
| Plod3 | -1548 | -837 |
| Ppib | 1319 | -3463 |
| Serpinh1 | -816 | 4009 |
REACTOME_HS_GAG_DEGRADATION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0905 |
| p.adjustMANOVA | 0.377 |
| s.dist | 0.374 |
| s.ctrl | -0.273 |
| s.Acss2KD | 0.255 |
| p.ctrl | 0.136 |
| p.Acss2KD | 0.162 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Hspg2 | -4014 | 4381 |
| Sdc2 | -2993 | 2423 |
| Idua | -1310 | 4340 |
| Ids | -659 | 2475 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Agrn | 2153 | 4136 |
| Gpc1 | -366 | -2222 |
| Gpc4 | -2811 | -4165 |
| Gusb | -3976 | -1163 |
| Hspg2 | -4014 | 4381 |
| Ids | -659 | 2475 |
| Idua | -1310 | 4340 |
| Sdc2 | -2993 | 2423 |
| Sdc3 | 1854 | -3087 |
| Sdc4 | 290 | 4407 |
REACTOME_METAL_ION_SLC_TRANSPORTERS
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.082 |
| p.adjustMANOVA | 0.364 |
| s.dist | 0.371 |
| s.ctrl | 0.00587 |
| s.Acss2KD | 0.371 |
| p.ctrl | 0.972 |
| p.Acss2KD | 0.0263 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Slc30a1 | 3090 | 3891 |
| Slc30a5 | 2732 | 3679 |
| Slc30a2 | 3538 | 1469 |
| Slc31a1 | 1040 | 3396 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Cp | -1719 | 1794 |
| Slc30a1 | 3090 | 3891 |
| Slc30a2 | 3538 | 1469 |
| Slc30a5 | 2732 | 3679 |
| Slc30a7 | -1138 | 3220 |
| Slc31a1 | 1040 | 3396 |
| Slc39a1 | -2489 | -3123 |
| Slc39a10 | -1122 | 4425 |
| Slc39a3 | 2227 | -1847 |
| Slc39a7 | 2730 | -410 |
| Slc40a1 | -3560 | 3012 |
| Slc41a1 | -4141 | 683 |
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0384 |
| p.adjustMANOVA | 0.247 |
| s.dist | 0.369 |
| s.ctrl | 0.214 |
| s.Acss2KD | -0.3 |
| p.ctrl | 0.165 |
| p.Acss2KD | 0.0518 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Map2k2 | 3542 | -4337 |
| Map2k1 | 2978 | -3334 |
| Shc1 | 2888 | -3311 |
| Ywhab | 3629 | -2108 |
| Grb2 | 2454 | -474 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Egf | -753 | -4618 |
| Egfr | -1274 | 3330 |
| Grb2 | 2454 | -474 |
| Hras | -248 | -3984 |
| Kras | -3480 | -453 |
| Map2k1 | 2978 | -3334 |
| Map2k2 | 3542 | -4337 |
| Mapk1 | 1017 | 639 |
| Mapk3 | 1658 | 1988 |
| Nras | -1199 | -2227 |
| Raf1 | -20 | -1469 |
| Shc1 | 2888 | -3311 |
| Sos1 | 3617 | 689 |
| Ywhab | 3629 | -2108 |
REACTOME_SHC_RELATED_EVENTS
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.041 |
| p.adjustMANOVA | 0.255 |
| s.dist | 0.369 |
| s.ctrl | 0.332 |
| s.Acss2KD | -0.161 |
| p.ctrl | 0.0317 |
| p.Acss2KD | 0.298 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Map2k2 | 3542 | -4337 |
| Map2k1 | 2978 | -3334 |
| Shc1 | 2888 | -3311 |
| Ywhab | 3629 | -2108 |
| Grb2 | 2454 | -474 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Grb2 | 2454 | -474 |
| Hras | -248 | -3984 |
| Insr | 1313 | 3529 |
| Kras | -3480 | -453 |
| Map2k1 | 2978 | -3334 |
| Map2k2 | 3542 | -4337 |
| Mapk1 | 1017 | 639 |
| Mapk3 | 1658 | 1988 |
| Nras | -1199 | -2227 |
| Raf1 | -20 | -1469 |
| Shc1 | 2888 | -3311 |
| Shc2 | 4235 | 4183 |
| Sos1 | 3617 | 689 |
| Ywhab | 3629 | -2108 |
REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0517 |
| p.adjustMANOVA | 0.295 |
| s.dist | 0.366 |
| s.ctrl | -0.191 |
| s.Acss2KD | 0.313 |
| p.ctrl | 0.234 |
| p.Acss2KD | 0.0511 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Hspg2 | -4014 | 4381 |
| Sdc2 | -2993 | 2423 |
| Dcn | -1776 | 4020 |
| Gxylt1 | -1647 | 53 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Agrn | 2153 | 4136 |
| B3gat3 | 408 | 3424 |
| B4galt7 | -2085 | -710 |
| Bgn | 249 | 3317 |
| Dcn | -1776 | 4020 |
| Gpc1 | -366 | -2222 |
| Gpc4 | -2811 | -4165 |
| Gxylt1 | -1647 | 53 |
| Hspg2 | -4014 | 4381 |
| Sdc2 | -2993 | 2423 |
| Sdc3 | 1854 | -3087 |
| Sdc4 | 290 | 4407 |
| Vcan | 257 | 2422 |
REACTOME_PLATELET_SENSITIZATION_BY_LDL
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.143 |
| p.adjustMANOVA | 0.458 |
| s.dist | 0.365 |
| s.ctrl | -0.255 |
| s.Acss2KD | -0.261 |
| p.ctrl | 0.143 |
| p.Acss2KD | 0.134 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Ppp2r5e | -3584 | -3626 |
| Ppp2r5b | -3191 | -2773 |
| Ppp2r1a | -1610 | -4003 |
| Ppp2r5a | -1142 | -3165 |
| Mapk14 | -1328 | -1405 |
| Ppp2r5d | -3494 | -528 |
| Ppp2cb | -971 | -1129 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Mapk14 | -1328 | -1405 |
| Pecam1 | -1180 | 1411 |
| Ppp2ca | 2167 | 4308 |
| Ppp2cb | -971 | -1129 |
| Ppp2r1a | -1610 | -4003 |
| Ppp2r1b | 4296 | -3027 |
| Ppp2r5a | -1142 | -3165 |
| Ppp2r5b | -3191 | -2773 |
| Ppp2r5c | -2097 | 473 |
| Ppp2r5d | -3494 | -528 |
| Ppp2r5e | -3584 | -3626 |
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.0739 |
| p.adjustMANOVA | 0.337 |
| s.dist | 0.36 |
| s.ctrl | -0.208 |
| s.Acss2KD | -0.294 |
| p.ctrl | 0.163 |
| p.Acss2KD | 0.0487 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Cdh5 | -4105 | -4132 |
| Cdh4 | -3165 | -3993 |
| F11r | -2571 | -4050 |
| Cldn5 | -2895 | -3389 |
| Jup | -3727 | -2465 |
| Pard6a | -3040 | -2699 |
| Pvr | -2059 | -3071 |
| Cdh13 | -1040 | -2092 |
| Cdh15 | -765 | -18 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Cadm1 | 4265 | -1651 |
| Cdh13 | -1040 | -2092 |
| Cdh15 | -765 | -18 |
| Cdh4 | -3165 | -3993 |
| Cdh5 | -4105 | -4132 |
| Cldn12 | 4069 | 4324 |
| Cldn5 | -2895 | -3389 |
| Ctnna1 | 3442 | -3921 |
| Ctnnb1 | -1916 | 593 |
| F11r | -2571 | -4050 |
| Jup | -3727 | -2465 |
| Pard3 | -1632 | 3398 |
| Pard6a | -3040 | -2699 |
| Prkci | 1837 | 2521 |
| Pvr | -2059 | -3071 |
REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.0242 |
| p.adjustMANOVA | 0.197 |
| s.dist | 0.357 |
| s.ctrl | 0.222 |
| s.Acss2KD | -0.28 |
| p.ctrl | 0.113 |
| p.Acss2KD | 0.0458 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Anapc4 | 3163 | -3834 |
| Ube2e1 | 4546 | -2044 |
| Bub3 | 3562 | -1342 |
| Anapc2 | 1956 | -2124 |
| Anapc5 | 3342 | -1132 |
| Anapc11 | 718 | -2850 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Anapc1 | 3012 | 1579 |
| Anapc10 | 665 | 318 |
| Anapc11 | 718 | -2850 |
| Anapc2 | 1956 | -2124 |
| Anapc4 | 3163 | -3834 |
| Anapc5 | 3342 | -1132 |
| Anapc7 | -277 | -1218 |
| Bub3 | 3562 | -1342 |
| Cdc16 | -3530 | 586 |
| Cdc23 | -2917 | -4053 |
| Cdc26 | -992 | -2007 |
| Cdc27 | -2236 | -2032 |
| Rps27a | 2463 | 645 |
| Uba52 | 1296 | 738 |
| Ube2c | 3977 | 492 |
| Ube2d1 | -163 | -4001 |
| Ube2e1 | 4546 | -2044 |
REACTOME_MRNA_SPLICING
| metric | value |
|---|---|
| setSize | 98 |
| pMANOVA | 9.57e-09 |
| p.adjustMANOVA | 2.6e-07 |
| s.dist | 0.356 |
| s.ctrl | 0.355 |
| s.Acss2KD | 0.0247 |
| p.ctrl | 1.31e-09 |
| p.Acss2KD | 0.673 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Sf3b1 | 4635 | 4565 |
| Hnrnpa1 | 4482 | 4277 |
| Srsf11 | 4364 | 4233 |
| Srsf6 | 4379 | 4043 |
| Dhx38 | 4459 | 3281 |
| Srsf2 | 3950 | 2962 |
| Hnrnpc | 3222 | 3608 |
| Pcbp2 | 3541 | 3156 |
| Srrm1 | 2405 | 4344 |
| Cstf1 | 3691 | 2779 |
| Cdc40 | 4428 | 2160 |
| Srsf7 | 4315 | 2214 |
| Hnrnph2 | 2528 | 3302 |
| Ccar1 | 3177 | 2236 |
| Cpsf1 | 2114 | 2871 |
| Hnrnph1 | 1338 | 4274 |
| Srsf3 | 2854 | 1989 |
| Hnrnpa2b1 | 2633 | 2107 |
| Eftud2 | 2455 | 1992 |
| Txnl4a | 1087 | 4076 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Ccar1 | 3177 | 2236 |
| Cd2bp2 | 1074 | -2774 |
| Cdc40 | 4428 | 2160 |
| Cpsf1 | 2114 | 2871 |
| Cpsf2 | -2327 | -2615 |
| Cpsf3 | -1524 | -2250 |
| Cpsf7 | 4470 | -2572 |
| Cstf1 | 3691 | 2779 |
| Cstf2 | -2390 | -1005 |
| Cstf3 | -1765 | 911 |
| Ddx23 | 157 | -3679 |
| Dhx38 | 4459 | 3281 |
| Dhx9 | 545 | 1775 |
| Dnajc8 | -2189 | 2115 |
| Eftud2 | 2455 | 1992 |
| Fus | 1053 | -169 |
| Gtf2f1 | 4311 | -1183 |
| Gtf2f2 | 3129 | 256 |
| Hnrnpa0 | 1786 | -4123 |
| Hnrnpa1 | 4482 | 4277 |
| Hnrnpa2b1 | 2633 | 2107 |
| Hnrnpa3 | 410 | 3304 |
| Hnrnpc | 3222 | 3608 |
| Hnrnpd | 4209 | -3383 |
| Hnrnpf | 3598 | 968 |
| Hnrnph1 | 1338 | 4274 |
| Hnrnph2 | 2528 | 3302 |
| Hnrnpk | 2139 | -2569 |
| Hnrnpl | 906 | 1447 |
| Hnrnpm | 4367 | -311 |
| Hnrnpr | 1332 | -1824 |
| Hnrnpu | 2786 | 1020 |
| Hnrnpul1 | 1972 | -2099 |
| Magoh | -1006 | -1392 |
| Ncbp1 | -949 | 421 |
| Ncbp2 | -146 | -2230 |
| Nfx1 | 3075 | -3286 |
| Nudt21 | -2366 | -1492 |
| Papola | -4128 | 2805 |
| Pcbp1 | 1888 | -2780 |
| Pcbp2 | 3541 | 3156 |
| Pcf11 | -1732 | 2816 |
| Phf5a | 3877 | -1907 |
| Polr2a | 4239 | -873 |
| Polr2b | -343 | 2509 |
| Polr2c | 2894 | 616 |
| Polr2d | -602 | -1600 |
| Polr2e | -49 | 176 |
| Polr2f | -3736 | -3959 |
| Polr2g | 453 | 1638 |
| Polr2h | 1675 | -2060 |
| Polr2i | 719 | 1808 |
| Polr2j | -987 | -93 |
| Polr2k | -3021 | -3287 |
| Polr2l | 937 | -4440 |
| Prpf4 | 2521 | -664 |
| Prpf6 | 3956 | -696 |
| Prpf8 | 1779 | -883 |
| Ptbp1 | 4204 | -2434 |
| Rbm5 | 3223 | -166 |
| Rnps1 | 2649 | 1465 |
| Sf3a1 | 2221 | 1278 |
| Sf3a2 | -428 | -4487 |
| Sf3a3 | 3614 | -1867 |
| Sf3b1 | 4635 | 4565 |
| Sf3b2 | 4095 | -3323 |
| Sf3b3 | 2543 | 1543 |
| Sf3b4 | 4310 | -3360 |
| Sf3b5 | 2622 | -1416 |
| Smc1a | 3522 | -755 |
| Snrnp200 | 2425 | 1709 |
| Snrnp40 | 593 | -2830 |
| Snrnp70 | 4594 | 814 |
| Snrpa | -1407 | 2166 |
| Snrpa1 | 3637 | 1158 |
| Snrpb | 1610 | -3967 |
| Snrpb2 | 2971 | -3259 |
| Snrpd1 | 3664 | 37 |
| Snrpd2 | -116 | -341 |
| Snrpd3 | -2304 | 3571 |
| Snrpe | 396 | -3169 |
| Snrpf | 1191 | -2494 |
| Srrm1 | 2405 | 4344 |
| Srsf1 | 2134 | 2000 |
| Srsf11 | 4364 | 4233 |
| Srsf2 | 3950 | 2962 |
| Srsf3 | 2854 | 1989 |
| Srsf4 | -2415 | -4369 |
| Srsf5 | 4586 | -1356 |
| Srsf6 | 4379 | 4043 |
| Srsf7 | 4315 | 2214 |
| Srsf9 | 1326 | 2676 |
| Sugp1 | 504 | -546 |
| Txnl4a | 1087 | 4076 |
| U2af1 | 1176 | 3716 |
| U2af2 | 3544 | -1850 |
| Upf3b | -1234 | 3676 |
| Ybx1 | 3337 | -1879 |
REACTOME_NCAM1_INTERACTIONS
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0393 |
| p.adjustMANOVA | 0.249 |
| s.dist | 0.346 |
| s.ctrl | -0.162 |
| s.Acss2KD | 0.306 |
| p.ctrl | 0.261 |
| p.Acss2KD | 0.0342 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Col6a1 | -4250 | 2642 |
| Col6a3 | -2636 | 3439 |
| Col4a1 | -1740 | 4372 |
| Col6a2 | -3653 | 832 |
| Col5a2 | -648 | 3204 |
| Col4a2 | -246 | 4244 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Agrn | 2153 | 4136 |
| Cacna1s | 3871 | 2767 |
| Cacnb1 | -2334 | -4616 |
| Col1a1 | 1664 | 2200 |
| Col1a2 | 1968 | 2611 |
| Col3a1 | 194 | 556 |
| Col4a1 | -1740 | 4372 |
| Col4a2 | -246 | 4244 |
| Col5a1 | 328 | 486 |
| Col5a2 | -648 | 3204 |
| Col6a1 | -4250 | 2642 |
| Col6a2 | -3653 | 832 |
| Col6a3 | -2636 | 3439 |
| Gfra1 | -950 | -635 |
| Nrtn | -3034 | -3735 |
| Prnp | -1479 | -349 |
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0703 |
| p.adjustMANOVA | 0.336 |
| s.dist | 0.345 |
| s.ctrl | -0.124 |
| s.Acss2KD | -0.322 |
| p.ctrl | 0.392 |
| p.Acss2KD | 0.0256 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Myo6 | -3357 | -2025 |
| Pick1 | -3368 | -1913 |
| Ap2s1 | -2667 | -1973 |
| Prkca | -2598 | -1826 |
| Nsf | -1828 | -1339 |
| Mdm2 | -147 | -1540 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Ap2a1 | 1533 | -3553 |
| Ap2a2 | 413 | -3049 |
| Ap2b1 | -3697 | 45 |
| Ap2m1 | -2176 | 3863 |
| Ap2s1 | -2667 | -1973 |
| Camk2a | 1101 | -2731 |
| Camk2b | 3004 | -1397 |
| Camk2d | 1539 | 591 |
| Dlg1 | 1050 | 444 |
| Epb41l1 | 2501 | -3371 |
| Grip2 | 746 | -4331 |
| Mdm2 | -147 | -1540 |
| Myo6 | -3357 | -2025 |
| Nsf | -1828 | -1339 |
| Pick1 | -3368 | -1913 |
| Prkca | -2598 | -1826 |
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.113 |
| p.adjustMANOVA | 0.424 |
| s.dist | 0.344 |
| s.ctrl | 0.137 |
| s.Acss2KD | -0.316 |
| p.ctrl | 0.433 |
| p.Acss2KD | 0.0696 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Map2k2 | 3542 | -4337 |
| Map2k1 | 2978 | -3334 |
| Ywhab | 3629 | -2108 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Braf | -11 | -382 |
| Hras | -248 | -3984 |
| Kras | -3480 | -453 |
| Map2k1 | 2978 | -3334 |
| Map2k2 | 3542 | -4337 |
| Mapk1 | 1017 | 639 |
| Mapk3 | 1658 | 1988 |
| Nras | -1199 | -2227 |
| Raf1 | -20 | -1469 |
| Rit1 | -151 | -591 |
| Ywhab | 3629 | -2108 |
REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 0.0174 |
| p.adjustMANOVA | 0.175 |
| s.dist | 0.341 |
| s.ctrl | 0.318 |
| s.Acss2KD | -0.124 |
| p.ctrl | 0.0117 |
| p.Acss2KD | 0.327 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Chmp6 | 3716 | -2921 |
| Vps25 | 2710 | -3313 |
| Chmp2a | 3959 | -2171 |
| Chmp2b | 1940 | -3567 |
| Vta1 | 2430 | -2156 |
| Chmp4b | 1109 | -4244 |
| Vps37a | 1310 | -2089 |
| Chmp3 | 1330 | -669 |
| Vps4a | 2762 | -221 |
| Chmp5 | 3741 | -66 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Chmp2a | 3959 | -2171 |
| Chmp2b | 1940 | -3567 |
| Chmp3 | 1330 | -669 |
| Chmp4b | 1109 | -4244 |
| Chmp5 | 3741 | -66 |
| Chmp6 | 3716 | -2921 |
| Chmp7 | -172 | -2881 |
| Hgs | 3331 | 3866 |
| Rps27a | 2463 | 645 |
| Snf8 | -1830 | -4355 |
| Stam | 153 | 1013 |
| Stam2 | 1339 | 3597 |
| Tsg101 | 207 | 3382 |
| Uba52 | 1296 | 738 |
| Vps25 | 2710 | -3313 |
| Vps36 | 1821 | 1073 |
| Vps37a | 1310 | -2089 |
| Vps37c | 1001 | 3427 |
| Vps4a | 2762 | -221 |
| Vps4b | -2396 | -1513 |
| Vta1 | 2430 | -2156 |
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 0.0133 |
| p.adjustMANOVA | 0.15 |
| s.dist | 0.341 |
| s.ctrl | -0.0228 |
| s.Acss2KD | 0.34 |
| p.ctrl | 0.847 |
| p.Acss2KD | 0.00393 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Slc16a1 | -3217 | 4488 |
| Slc40a1 | -3560 | 3012 |
| Slc47a1 | -2112 | 3903 |
| Slc2a12 | -2211 | 3065 |
| Slc39a10 | -1122 | 4425 |
| Slc2a4 | -1773 | 2466 |
| Slc30a7 | -1138 | 3220 |
| Cp | -1719 | 1794 |
| Slc41a1 | -4141 | 683 |
| Slc2a1 | -404 | 3291 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Cp | -1719 | 1794 |
| Slc16a1 | -3217 | 4488 |
| Slc16a3 | 1223 | -1989 |
| Slc22a5 | 3998 | 3126 |
| Slc2a1 | -404 | 3291 |
| Slc2a12 | -2211 | 3065 |
| Slc2a3 | 3636 | 2579 |
| Slc2a4 | -1773 | 2466 |
| Slc2a8 | 3311 | 406 |
| Slc30a1 | 3090 | 3891 |
| Slc30a2 | 3538 | 1469 |
| Slc30a5 | 2732 | 3679 |
| Slc30a7 | -1138 | 3220 |
| Slc31a1 | 1040 | 3396 |
| Slc39a1 | -2489 | -3123 |
| Slc39a10 | -1122 | 4425 |
| Slc39a3 | 2227 | -1847 |
| Slc39a7 | 2730 | -410 |
| Slc40a1 | -3560 | 3012 |
| Slc41a1 | -4141 | 683 |
| Slc44a1 | 379 | 2551 |
| Slc44a2 | -274 | -4134 |
| Slc47a1 | -2112 | 3903 |
| Slc6a6 | -4527 | -2952 |
REACTOME_INSULIN_RECEPTOR_RECYCLING
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.098 |
| p.adjustMANOVA | 0.394 |
| s.dist | 0.339 |
| s.ctrl | 0.174 |
| s.Acss2KD | 0.291 |
| p.ctrl | 0.244 |
| p.Acss2KD | 0.0512 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Atp6v1b2 | 3911 | 4522 |
| Atp6v1h | 1974 | 4119 |
| Atp6v0e | 3511 | 1487 |
| Atp6v0d1 | 1179 | 4073 |
| Insr | 1313 | 3529 |
| Atp6v1g1 | 4328 | 585 |
| Atp6v0b | 1716 | 1113 |
| Atp6v1e1 | 2416 | 663 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Atp6v0a2 | -548 | -2378 |
| Atp6v0b | 1716 | 1113 |
| Atp6v0c | 3772 | -2383 |
| Atp6v0d1 | 1179 | 4073 |
| Atp6v0e | 3511 | 1487 |
| Atp6v1a | -3458 | 3741 |
| Atp6v1b2 | 3911 | 4522 |
| Atp6v1c1 | -2944 | 2244 |
| Atp6v1d | -2298 | -2151 |
| Atp6v1e1 | 2416 | 663 |
| Atp6v1f | -2137 | 2559 |
| Atp6v1g1 | 4328 | 585 |
| Atp6v1h | 1974 | 4119 |
| Insr | 1313 | 3529 |
| Tcirg1 | 333 | -1991 |
REACTOME_GLUCONEOGENESIS
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 0.0503 |
| p.adjustMANOVA | 0.29 |
| s.dist | 0.337 |
| s.ctrl | -0.127 |
| s.Acss2KD | -0.312 |
| p.ctrl | 0.337 |
| p.Acss2KD | 0.0185 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Slc25a11 | -4064 | -2610 |
| Pck1 | -2329 | -4296 |
| Pgam2 | -2769 | -3600 |
| Mdh2 | -4028 | -1792 |
| Prkaca | -1333 | -2994 |
| Tpi1 | -828 | -2975 |
| Slc25a12 | -1601 | -175 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Eno1 | 3022 | -3814 |
| Eno3 | 1752 | -1167 |
| Fbp2 | 1951 | -979 |
| Got1 | -4127 | 4055 |
| Got2 | -3934 | 3036 |
| Gpi1 | 4426 | 877 |
| Mdh1 | -4331 | 2245 |
| Mdh2 | -4028 | -1792 |
| Pck1 | -2329 | -4296 |
| Pcx | 4350 | -3810 |
| Pfkfb1 | 497 | -181 |
| Pgam1 | 1448 | -2789 |
| Pgam2 | -2769 | -3600 |
| Pgk1 | 832 | -2438 |
| Prkaca | -1333 | -2994 |
| Prkacb | 1320 | -4312 |
| Slc25a11 | -4064 | -2610 |
| Slc25a12 | -1601 | -175 |
| Tpi1 | -828 | -2975 |
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.045 |
| p.adjustMANOVA | 0.27 |
| s.dist | 0.337 |
| s.ctrl | 0.188 |
| s.Acss2KD | -0.279 |
| p.ctrl | 0.192 |
| p.Acss2KD | 0.0531 |
| Gene | ctrl | Acss2KD |
|---|---|---|
| Anapc4 | 3163 | -3834 |
| Ube2e1 | 4546 | -2044 |
| Anapc2 | 1956 | -2124 |
| Anapc5 | 3342 | -1132 |
| Anapc11 | 718 | -2850 |
Click HERE to show all gene set members
| ctrl | Acss2KD | |
|---|---|---|
| Anapc1 | 3012 | 1579 |
| Anapc10 | 665 | 318 |
| Anapc11 | 718 | -2850 |
| Anapc2 | 1956 | -2124 |
| Anapc4 | 3163 | -3834 |
| Anapc5 | 3342 | -1132 |
| Anapc7 | -277 | -1218 |
| Cdc16 | -3530 | 586 |
| Cdc23 | -2917 | -4053 |
| Cdc26 | -992 | -2007 |
| Cdc27 | -2236 | -2032 |
| Rps27a | 2463 | 645 |
| Uba52 | 1296 | 738 |
| Ube2c | 3977 | 492 |
| Ube2d1 | -163 | -4001 |
| Ube2e1 | 4546 | -2044 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] plyr_1.8.7 pkgload_1.3.0
## [3] GGally_2.1.2 gtools_3.9.2.2
## [5] echarts4r_0.4.4 beeswarm_0.4.0
## [7] vioplot_0.3.7 sm_2.2-5.7
## [9] kableExtra_1.3.4 topconfects_1.12.0
## [11] limma_3.52.1 eulerr_6.1.1
## [13] mitch_1.8.0 MASS_7.3-58
## [15] fgsea_1.22.0 gplots_3.1.3
## [17] DESeq2_1.36.0 SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0 MatrixGenerics_1.8.0
## [21] matrixStats_0.62.0 GenomicRanges_1.48.0
## [23] GenomeInfoDb_1.32.2 IRanges_2.30.0
## [25] S4Vectors_0.34.0 BiocGenerics_0.42.0
## [27] reshape2_1.4.4 forcats_0.5.1
## [29] stringr_1.4.0 dplyr_1.0.9
## [31] purrr_0.3.4 readr_2.1.2
## [33] tidyr_1.2.0 tibble_3.1.7
## [35] ggplot2_3.3.6 tidyverse_1.3.1
## [37] zoo_1.8-10
##
## loaded via a namespace (and not attached):
## [1] readxl_1.4.0 backports_1.4.1 fastmatch_1.1-3
## [4] systemfonts_1.0.4 splines_4.2.1 BiocParallel_1.30.3
## [7] digest_0.6.29 htmltools_0.5.2 fansi_1.0.3
## [10] magrittr_2.0.3 memoise_2.0.1 tzdb_0.3.0
## [13] Biostrings_2.64.0 annotate_1.74.0 modelr_0.1.8
## [16] svglite_2.1.0 prettyunits_1.1.1 colorspace_2.0-3
## [19] blob_1.2.3 rvest_1.0.2 haven_2.5.0
## [22] xfun_0.31 crayon_1.5.1 RCurl_1.98-1.7
## [25] jsonlite_1.8.0 genefilter_1.78.0 survival_3.4-0
## [28] glue_1.6.2 gtable_0.3.0 zlibbioc_1.42.0
## [31] XVector_0.36.0 webshot_0.5.3 DelayedArray_0.22.0
## [34] scales_1.2.0 DBI_1.1.3 Rcpp_1.0.8.3
## [37] viridisLite_0.4.0 xtable_1.8-4 progress_1.2.2
## [40] bit_4.0.4 htmlwidgets_1.5.4 httr_1.4.3
## [43] RColorBrewer_1.1-3 ellipsis_0.3.2 pkgconfig_2.0.3
## [46] reshape_0.8.9 XML_3.99-0.10 farver_2.1.0
## [49] sass_0.4.1 dbplyr_2.2.1 locfit_1.5-9.5
## [52] utf8_1.2.2 tidyselect_1.1.2 labeling_0.4.2
## [55] rlang_1.0.3 later_1.3.0 AnnotationDbi_1.58.0
## [58] munsell_0.5.0 cellranger_1.1.0 tools_4.2.1
## [61] cachem_1.0.6 cli_3.3.0 generics_0.1.2
## [64] RSQLite_2.2.14 broom_0.8.0 evaluate_0.15
## [67] fastmap_1.1.0 yaml_2.3.5 knitr_1.39
## [70] bit64_4.0.5 fs_1.5.2 caTools_1.18.2
## [73] KEGGREST_1.36.2 mime_0.12 xml2_1.3.3
## [76] compiler_4.2.1 rstudioapi_0.13 png_0.1-7
## [79] reprex_2.0.1 geneplotter_1.74.0 bslib_0.3.1
## [82] stringi_1.7.6 highr_0.9 lattice_0.20-45
## [85] Matrix_1.4-1 vctrs_0.4.1 pillar_1.7.0
## [88] lifecycle_1.0.1 jquerylib_0.1.4 data.table_1.14.2
## [91] bitops_1.0-7 httpuv_1.6.5 R6_2.5.1
## [94] promises_1.2.0.1 KernSmooth_2.23-20 gridExtra_2.3
## [97] codetools_0.2-18 assertthat_0.2.1 withr_2.5.0
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1 hms_1.1.1
## [103] grid_4.2.1 rmarkdown_2.14 shiny_1.7.1
## [106] lubridate_1.8.0END of report