date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     stat
## 0610009B22Rik  1.6344600
## 0610009L18Rik  1.0145872
## 0610010K14Rik  0.1633529
## 0610012G03Rik  0.5937955
## 0610030E20Rik -0.7027218
## 0610040J01Rik -0.0895336
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 674
num_genes_in_profile 9724
duplicated_genes_present 0
num_profile_genes_in_sets 2889
num_profile_genes_not_in_sets 6835

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt
Gene sets metrics
Gene sets metrics
num_genesets 674
num_genesets_excluded 203
num_genesets_included 471

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 8.01e-07 0.823 3.14e-05
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 73 9.13e-22 0.649 2.15e-19
REACTOME RESPIRATORY ELECTRON TRANSPORT 59 1.31e-17 0.643 2.05e-15
REACTOME PYRUVATE METABOLISM 16 2.35e-05 0.611 6.93e-04
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 107 9.33e-27 0.599 4.39e-24
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 7.06e-04 0.590 1.19e-02
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 1.79e-05 0.569 5.62e-04
REACTOME COMPLEMENT CASCADE 10 1.99e-03 -0.565 2.76e-02
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 22 1.41e-05 -0.535 4.76e-04
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 9.05e-04 0.532 1.38e-02
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 13 1.46e-03 -0.510 2.08e-02
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 5.69e-08 0.509 2.44e-06
REACTOME PEPTIDE CHAIN ELONGATION 67 8.26e-13 -0.506 9.73e-11
REACTOME CALNEXIN CALRETICULIN CYCLE 11 4.27e-03 -0.498 4.68e-02
REACTOME G PROTEIN ACTIVATION 10 1.44e-02 -0.447 1.06e-01
REACTOME TCR SIGNALING 30 2.80e-05 -0.442 7.38e-04
REACTOME METABOLISM OF POLYAMINES 13 6.15e-03 0.439 5.91e-02
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 15 4.36e-03 -0.425 4.68e-02
REACTOME EFFECTS OF PIP2 HYDROLYSIS 15 5.80e-03 -0.412 5.81e-02
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 89 2.47e-11 -0.410 2.32e-09
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 42 4.97e-06 -0.407 1.80e-04
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 83 1.48e-10 -0.407 1.16e-08
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS 11 2.20e-02 -0.399 1.30e-01
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 85 7.92e-10 -0.386 5.33e-08
REACTOME INTERFERON GAMMA SIGNALING 32 1.80e-04 -0.383 4.05e-03
REACTOME GLUTATHIONE CONJUGATION 12 2.63e-02 0.371 1.39e-01
REACTOME STRIATED MUSCLE CONTRACTION 22 3.22e-03 0.363 3.80e-02
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 86 7.60e-09 -0.361 4.47e-07
REACTOME RAP1 SIGNALLING 12 3.29e-02 -0.356 1.60e-01
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 10 5.36e-02 -0.353 2.12e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT 42 1.45e-04 0.339 3.60e-03
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 18 1.30e-02 -0.338 9.89e-02
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 18 1.62e-02 0.327 1.11e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 16 2.37e-02 0.327 1.33e-01
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 11 6.07e-02 -0.327 2.17e-01
REACTOME SIGNAL AMPLIFICATION 14 3.48e-02 -0.326 1.60e-01
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 23 7.38e-03 -0.323 6.82e-02
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 11 6.45e-02 0.322 2.28e-01
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 18 1.95e-02 -0.318 1.22e-01
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 16 2.78e-02 -0.318 1.42e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 11 6.90e-02 -0.317 2.30e-01
REACTOME ADP SIGNALLING THROUGH P2RY1 11 7.00e-02 -0.316 2.31e-01
REACTOME DOWNSTREAM TCR SIGNALING 20 1.61e-02 -0.311 1.11e-01
REACTOME INFLUENZA LIFE CYCLE 115 1.77e-08 -0.305 9.27e-07
REACTOME BASE EXCISION REPAIR 13 5.92e-02 -0.302 2.16e-01
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 49 2.56e-04 -0.302 5.03e-03
REACTOME REGULATION OF KIT SIGNALING 12 7.16e-02 -0.301 2.34e-01
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 20 2.19e-02 -0.296 1.30e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 11 9.16e-02 -0.294 2.68e-01
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 6.73e-02 -0.293 2.30e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 8.01e-07 0.823000 3.14e-05
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 73 9.13e-22 0.649000 2.15e-19
REACTOME RESPIRATORY ELECTRON TRANSPORT 59 1.31e-17 0.643000 2.05e-15
REACTOME PYRUVATE METABOLISM 16 2.35e-05 0.611000 6.93e-04
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 107 9.33e-27 0.599000 4.39e-24
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 7.06e-04 0.590000 1.19e-02
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 1.79e-05 0.569000 5.62e-04
REACTOME COMPLEMENT CASCADE 10 1.99e-03 -0.565000 2.76e-02
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 22 1.41e-05 -0.535000 4.76e-04
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 9.05e-04 0.532000 1.38e-02
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 13 1.46e-03 -0.510000 2.08e-02
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 5.69e-08 0.509000 2.44e-06
REACTOME PEPTIDE CHAIN ELONGATION 67 8.26e-13 -0.506000 9.73e-11
REACTOME CALNEXIN CALRETICULIN CYCLE 11 4.27e-03 -0.498000 4.68e-02
REACTOME G PROTEIN ACTIVATION 10 1.44e-02 -0.447000 1.06e-01
REACTOME TCR SIGNALING 30 2.80e-05 -0.442000 7.38e-04
REACTOME METABOLISM OF POLYAMINES 13 6.15e-03 0.439000 5.91e-02
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 15 4.36e-03 -0.425000 4.68e-02
REACTOME EFFECTS OF PIP2 HYDROLYSIS 15 5.80e-03 -0.412000 5.81e-02
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 89 2.47e-11 -0.410000 2.32e-09
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 42 4.97e-06 -0.407000 1.80e-04
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 83 1.48e-10 -0.407000 1.16e-08
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS 11 2.20e-02 -0.399000 1.30e-01
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 85 7.92e-10 -0.386000 5.33e-08
REACTOME INTERFERON GAMMA SIGNALING 32 1.80e-04 -0.383000 4.05e-03
REACTOME GLUTATHIONE CONJUGATION 12 2.63e-02 0.371000 1.39e-01
REACTOME STRIATED MUSCLE CONTRACTION 22 3.22e-03 0.363000 3.80e-02
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 86 7.60e-09 -0.361000 4.47e-07
REACTOME RAP1 SIGNALLING 12 3.29e-02 -0.356000 1.60e-01
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 10 5.36e-02 -0.353000 2.12e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT 42 1.45e-04 0.339000 3.60e-03
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 18 1.30e-02 -0.338000 9.89e-02
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 18 1.62e-02 0.327000 1.11e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 16 2.37e-02 0.327000 1.33e-01
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 11 6.07e-02 -0.327000 2.17e-01
REACTOME SIGNAL AMPLIFICATION 14 3.48e-02 -0.326000 1.60e-01
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 23 7.38e-03 -0.323000 6.82e-02
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 11 6.45e-02 0.322000 2.28e-01
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 18 1.95e-02 -0.318000 1.22e-01
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 16 2.78e-02 -0.318000 1.42e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 11 6.90e-02 -0.317000 2.30e-01
REACTOME ADP SIGNALLING THROUGH P2RY1 11 7.00e-02 -0.316000 2.31e-01
REACTOME DOWNSTREAM TCR SIGNALING 20 1.61e-02 -0.311000 1.11e-01
REACTOME INFLUENZA LIFE CYCLE 115 1.77e-08 -0.305000 9.27e-07
REACTOME BASE EXCISION REPAIR 13 5.92e-02 -0.302000 2.16e-01
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 49 2.56e-04 -0.302000 5.03e-03
REACTOME REGULATION OF KIT SIGNALING 12 7.16e-02 -0.301000 2.34e-01
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 20 2.19e-02 -0.296000 1.30e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 11 9.16e-02 -0.294000 2.68e-01
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 6.73e-02 -0.293000 2.30e-01
REACTOME GLYCOSPHINGOLIPID METABOLISM 23 1.60e-02 -0.290000 1.11e-01
REACTOME TRANSLATION 124 2.97e-08 -0.289000 1.40e-06
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 18 3.42e-02 0.288000 1.60e-01
REACTOME REGULATION OF IFNA SIGNALING 10 1.15e-01 -0.288000 3.05e-01
REACTOME TELOMERE MAINTENANCE 20 2.61e-02 -0.287000 1.39e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 21 2.39e-02 0.285000 1.33e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY 37 3.06e-03 -0.282000 3.79e-02
REACTOME PLATELET AGGREGATION PLUG FORMATION 19 3.49e-02 -0.280000 1.60e-01
REACTOME INTERFERON ALPHA BETA SIGNALING 24 1.78e-02 -0.280000 1.16e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 24 1.83e-02 0.278000 1.18e-01
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 18 4.19e-02 -0.277000 1.79e-01
REACTOME LYSOSOME VESICLE BIOGENESIS 18 4.26e-02 -0.276000 1.79e-01
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA 13 8.96e-02 0.272000 2.67e-01
REACTOME PHASE II CONJUGATION 24 2.16e-02 0.271000 1.30e-01
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 14 8.07e-02 0.270000 2.49e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 29 1.23e-02 0.269000 9.67e-02
REACTOME GPVI MEDIATED ACTIVATION CASCADE 19 4.36e-02 -0.268000 1.80e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 29 1.30e-02 0.267000 9.89e-02
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 44 2.51e-03 0.264000 3.28e-02
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 25 2.33e-02 0.262000 1.33e-01
REACTOME METABOLISM OF PORPHYRINS 12 1.16e-01 0.262000 3.06e-01
REACTOME POTASSIUM CHANNELS 22 3.36e-02 0.262000 1.60e-01
REACTOME CHROMOSOME MAINTENANCE 38 5.64e-03 -0.260000 5.77e-02
REACTOME G ALPHA Z SIGNALLING EVENTS 21 3.96e-02 -0.260000 1.71e-01
REACTOME MRNA SPLICING MINOR PATHWAY 39 5.11e-03 -0.259000 5.35e-02
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 11 1.40e-01 -0.257000 3.42e-01
REACTOME LAGGING STRAND SYNTHESIS 10 1.59e-01 -0.257000 3.70e-01
REACTOME MEIOSIS 26 2.34e-02 -0.257000 1.33e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING 12 1.26e-01 -0.255000 3.18e-01
REACTOME P75NTR SIGNALS VIA NFKB 10 1.64e-01 -0.254000 3.76e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 17 6.98e-02 0.254000 2.31e-01
REACTOME LIPOPROTEIN METABOLISM 12 1.30e-01 -0.252000 3.26e-01
REACTOME MEIOTIC SYNAPSIS 17 7.58e-02 -0.249000 2.43e-01
REACTOME MRNA SPLICING 100 2.82e-05 -0.243000 7.38e-04
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 51 3.23e-03 -0.239000 3.80e-02
REACTOME RECYCLING PATHWAY OF L1 20 6.58e-02 -0.238000 2.30e-01
REACTOME PLC BETA MEDIATED EVENTS 21 5.96e-02 -0.238000 2.16e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 10 1.95e-01 -0.237000 4.08e-01
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 46 5.93e-03 0.235000 5.82e-02
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT 19 8.26e-02 -0.230000 2.49e-01
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 43 9.19e-03 0.230000 7.99e-02
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 44 8.62e-03 -0.229000 7.72e-02
REACTOME SIGNALING BY NOTCH2 12 1.72e-01 -0.228000 3.85e-01
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 44 9.50e-03 0.226000 7.99e-02
REACTOME VIRAL MESSENGER RNA SYNTHESIS 14 1.43e-01 -0.226000 3.48e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION 62 2.34e-03 -0.224000 3.15e-02
REACTOME ELONGATION ARREST AND RECOVERY 24 5.81e-02 -0.224000 2.16e-01
REACTOME SIGNALING BY NOTCH4 12 1.82e-01 -0.223000 3.92e-01
REACTOME DESTABILIZATION OF MRNA BY BRF1 16 1.23e-01 -0.223000 3.17e-01
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN 18 1.03e-01 0.222000 2.93e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 23 6.79e-02 -0.220000 2.30e-01
REACTOME DAG AND IP3 SIGNALING 17 1.17e-01 -0.219000 3.07e-01
REACTOME SIGNALING BY NOTCH3 12 1.92e-01 -0.217000 4.06e-01
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 41 1.67e-02 0.216000 1.13e-01
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS 17 1.25e-01 -0.215000 3.17e-01
REACTOME GLUCONEOGENESIS 20 9.82e-02 0.214000 2.82e-01
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 27 5.49e-02 0.214000 2.14e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 43 1.55e-02 0.214000 1.11e-01
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 47 1.17e-02 0.213000 9.48e-02
REACTOME PLATELET SENSITIZATION BY LDL 12 2.02e-01 -0.213000 4.15e-01
REACTOME NOD1 2 SIGNALING PATHWAY 21 9.17e-02 -0.213000 2.68e-01
REACTOME DNA STRAND ELONGATION 14 1.70e-01 -0.212000 3.83e-01
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 42 1.77e-02 -0.212000 1.16e-01
REACTOME HS GAG DEGRADATION 11 2.24e-01 -0.212000 4.42e-01
REACTOME DESTABILIZATION OF MRNA BY KSRP 14 1.73e-01 -0.210000 3.85e-01
REACTOME MTORC1 MEDIATED SIGNALLING 11 2.30e-01 0.209000 4.50e-01
REACTOME G ALPHA I SIGNALLING EVENTS 31 4.55e-02 -0.208000 1.86e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 28 5.79e-02 -0.207000 2.16e-01
REACTOME REGULATION OF IFNG SIGNALING 12 2.16e-01 -0.207000 4.29e-01
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 13 1.99e-01 -0.206000 4.15e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 110 2.05e-04 0.206000 4.19e-03
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 51 1.17e-02 0.204000 9.48e-02
REACTOME APOPTOTIC EXECUTION PHASE 30 5.41e-02 -0.203000 2.12e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 116 1.64e-04 -0.203000 3.87e-03
REACTOME NEPHRIN INTERACTIONS 15 1.80e-01 -0.200000 3.91e-01
REACTOME GLUCOSE METABOLISM 45 2.14e-02 0.199000 1.30e-01
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 43 2.51e-02 0.198000 1.37e-01
REACTOME TRANSCRIPTION COUPLED NER TC NER 37 3.78e-02 -0.198000 1.67e-01
REACTOME IL 3 5 AND GM CSF SIGNALING 29 6.63e-02 -0.197000 2.30e-01
REACTOME CIRCADIAN CLOCK 43 2.62e-02 0.196000 1.39e-01
REACTOME PKB MEDIATED EVENTS 28 7.27e-02 0.196000 2.36e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 22 1.13e-01 -0.195000 3.05e-01
REACTOME REGULATION OF SIGNALING BY CBL 15 1.92e-01 -0.195000 4.06e-01
REACTOME EXTENSION OF TELOMERES 15 1.93e-01 -0.194000 4.06e-01
REACTOME SYNTHESIS OF PA 12 2.45e-01 0.194000 4.69e-01
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 21 1.26e-01 -0.193000 3.18e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 127 2.01e-04 -0.192000 4.19e-03
REACTOME SYNTHESIS OF PC 10 2.94e-01 0.192000 5.18e-01
REACTOME GLUCOSE TRANSPORT 31 6.65e-02 0.191000 2.30e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 33 5.87e-02 0.190000 2.16e-01
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 15 2.04e-01 -0.189000 4.15e-01
REACTOME IL 2 SIGNALING 29 7.98e-02 -0.188000 2.49e-01
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 43 3.34e-02 0.188000 1.60e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 41 3.85e-02 0.187000 1.68e-01
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 32 6.89e-02 -0.186000 2.30e-01
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 46 2.96e-02 0.186000 1.48e-01
REACTOME COLLAGEN FORMATION 27 9.82e-02 -0.184000 2.82e-01
REACTOME MUSCLE CONTRACTION 36 5.67e-02 0.184000 2.16e-01
REACTOME SIGNALING BY HIPPO 15 2.18e-01 -0.184000 4.32e-01
REACTOME BASIGIN INTERACTIONS 14 2.35e-01 0.183000 4.56e-01
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 37 5.40e-02 -0.183000 2.12e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 10 3.16e-01 -0.183000 5.41e-01
REACTOME NETRIN1 SIGNALING 23 1.33e-01 -0.181000 3.31e-01
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 10 3.26e-01 -0.180000 5.50e-01
REACTOME RNA POL II TRANSCRIPTION 85 4.37e-03 -0.179000 4.68e-02
REACTOME REGULATORY RNA PATHWAYS 21 1.56e-01 -0.179000 3.65e-01
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 11 3.06e-01 -0.178000 5.35e-01
REACTOME MRNA PROCESSING 141 2.77e-04 -0.178000 5.22e-03
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX 28 1.05e-01 -0.177000 2.95e-01
REACTOME CD28 CO STIMULATION 22 1.52e-01 -0.177000 3.58e-01
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 19 1.85e-01 0.176000 3.97e-01
REACTOME SPHINGOLIPID METABOLISM 39 5.81e-02 -0.176000 2.16e-01
REACTOME REGULATION OF INSULIN SECRETION 40 5.63e-02 -0.175000 2.16e-01
REACTOME NCAM1 INTERACTIONS 15 2.42e-01 -0.175000 4.67e-01
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 14 2.59e-01 -0.174000 4.78e-01
REACTOME IL RECEPTOR SHC SIGNALING 17 2.14e-01 -0.174000 4.29e-01
REACTOME EGFR DOWNREGULATION 23 1.51e-01 -0.173000 3.58e-01
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 49 3.77e-02 -0.172000 1.67e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT 22 1.64e-01 -0.172000 3.76e-01
REACTOME NUCLEOTIDE EXCISION REPAIR 41 5.99e-02 -0.170000 2.16e-01
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 19 2.00e-01 -0.170000 4.15e-01
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 57 2.70e-02 0.170000 1.40e-01
REACTOME REGULATION OF MITOTIC CELL CYCLE 61 2.23e-02 0.169000 1.30e-01
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 36 8.07e-02 -0.168000 2.49e-01
REACTOME DNA REPAIR 71 1.45e-02 -0.168000 1.06e-01
REACTOME MRNA 3 END PROCESSING 31 1.08e-01 -0.167000 3.03e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 57 3.02e-02 0.166000 1.48e-01
REACTOME GAB1 SIGNALOSOME 33 1.00e-01 -0.166000 2.86e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 16 2.53e-01 -0.165000 4.76e-01
REACTOME REGULATION OF APOPTOSIS 49 4.71e-02 0.164000 1.91e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 23 1.74e-01 -0.164000 3.85e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 16 2.60e-01 -0.163000 4.78e-01
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 13 3.11e-01 -0.163000 5.41e-01
REACTOME CHOLESTEROL BIOSYNTHESIS 13 3.11e-01 -0.162000 5.41e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN 50 4.86e-02 0.161000 1.96e-01
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 54 4.23e-02 0.160000 1.79e-01
REACTOME SIGNALING BY WNT 57 3.80e-02 0.159000 1.67e-01
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX 28 1.46e-01 -0.159000 3.52e-01
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 17 2.62e-01 -0.157000 4.78e-01
REACTOME DARPP 32 EVENTS 18 2.50e-01 0.157000 4.73e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 22 2.04e-01 -0.157000 4.15e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 21 2.15e-01 -0.156000 4.29e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 22 2.04e-01 0.156000 4.15e-01
REACTOME G1 PHASE 25 1.78e-01 -0.156000 3.91e-01
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 17 2.68e-01 0.155000 4.85e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 3.76e-01 0.154000 6.07e-01
REACTOME SIGNALING BY FGFR MUTANTS 28 1.65e-01 -0.152000 3.77e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 101 9.43e-03 0.150000 7.99e-02
REACTOME GABA B RECEPTOR ACTIVATION 14 3.34e-01 -0.149000 5.59e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 170 8.90e-04 0.148000 1.38e-02
REACTOME G ALPHA Q SIGNALLING EVENTS 45 8.54e-02 -0.148000 2.56e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS 37 1.19e-01 0.148000 3.10e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 32 1.52e-01 0.146000 3.58e-01
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 131 4.03e-03 0.146000 4.63e-02
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 21 2.48e-01 -0.146000 4.72e-01
REACTOME CTLA4 INHIBITORY SIGNALING 16 3.16e-01 -0.145000 5.41e-01
REACTOME METABOLISM OF MRNA 179 8.99e-04 -0.145000 1.38e-02
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 66 4.36e-02 -0.144000 1.80e-01
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 49 8.20e-02 0.144000 2.49e-01
REACTOME ERK MAPK TARGETS 19 2.79e-01 0.143000 4.97e-01
REACTOME SIGNALING BY FGFR1 MUTANTS 21 2.55e-01 -0.143000 4.76e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 2.45e-01 0.143000 4.69e-01
REACTOME GLYCOLYSIS 19 2.80e-01 0.143000 4.97e-01
REACTOME SIGNALING BY NODAL 11 4.11e-01 0.143000 6.30e-01
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 12 3.95e-01 -0.142000 6.17e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 10 4.39e-01 -0.141000 6.54e-01
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 13 3.80e-01 -0.141000 6.09e-01
REACTOME MEMBRANE TRAFFICKING 94 1.89e-02 -0.140000 1.21e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 53 7.77e-02 0.140000 2.47e-01
REACTOME M G1 TRANSITION 52 8.08e-02 0.140000 2.49e-01
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 35 1.54e-01 -0.139000 3.61e-01
REACTOME SIGNALING BY EGFR IN CANCER 85 2.86e-02 -0.138000 1.45e-01
REACTOME INNATE IMMUNE SYSTEM 130 7.17e-03 -0.137000 6.75e-02
REACTOME SIGNAL ATTENUATION 10 4.56e-01 0.136000 6.69e-01
REACTOME TRANSCRIPTION 126 8.69e-03 -0.136000 7.72e-02
REACTOME CA DEPENDENT EVENTS 14 3.79e-01 -0.136000 6.09e-01
REACTOME GABA RECEPTOR ACTIVATION 15 3.63e-01 -0.136000 5.94e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 13 4.03e-01 -0.134000 6.23e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 11 4.42e-01 -0.134000 6.56e-01
REACTOME HIV LIFE CYCLE 94 2.67e-02 -0.133000 1.40e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 23 2.72e-01 -0.132000 4.90e-01
REACTOME SEMAPHORIN INTERACTIONS 43 1.36e-01 -0.131000 3.37e-01
REACTOME HEMOSTASIS 234 6.16e-04 -0.131000 1.08e-02
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 63 7.54e-02 -0.130000 2.43e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 107 2.08e-02 -0.130000 1.29e-01
REACTOME MICRORNA MIRNA BIOGENESIS 18 3.42e-01 -0.129000 5.71e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM 52 1.10e-01 -0.128000 3.05e-01
REACTOME INTEGRATION OF ENERGY METABOLISM 63 8.16e-02 -0.127000 2.49e-01
REACTOME SIGNALING BY ROBO RECEPTOR 20 3.26e-01 -0.127000 5.50e-01
REACTOME INWARDLY RECTIFYING K CHANNELS 10 4.88e-01 0.127000 6.94e-01
REACTOME INTERFERON SIGNALING 94 3.54e-02 -0.126000 1.60e-01
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 54 1.10e-01 0.126000 3.05e-01
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 16 3.86e-01 0.125000 6.12e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 13 4.36e-01 -0.125000 6.52e-01
REACTOME BIOLOGICAL OXIDATIONS 40 1.80e-01 0.123000 3.91e-01
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 43 1.71e-01 0.121000 3.84e-01
REACTOME PEROXISOMAL LIPID METABOLISM 16 4.03e-01 -0.121000 6.23e-01
REACTOME SULFUR AMINO ACID METABOLISM 19 3.65e-01 0.120000 5.95e-01
REACTOME CELL CYCLE CHECKPOINTS 79 6.68e-02 0.120000 2.30e-01
REACTOME METABOLISM OF RNA 218 2.81e-03 -0.118000 3.58e-02
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 13 4.64e-01 -0.117000 6.75e-01
REACTOME SIGNALING BY SCF KIT 61 1.16e-01 -0.117000 3.06e-01
REACTOME RNA POL III TRANSCRIPTION TERMINATION 18 3.93e-01 0.116000 6.16e-01
REACTOME PI 3K CASCADE 35 2.35e-01 -0.116000 4.56e-01
REACTOME CELL CELL COMMUNICATION 56 1.33e-01 -0.116000 3.31e-01
REACTOME METABOLISM OF PROTEINS 310 5.02e-04 -0.116000 9.09e-03
REACTOME SIGNALING BY BMP 17 4.09e-01 0.116000 6.30e-01
REACTOME SIGNALING BY FGFR 72 9.09e-02 -0.115000 2.68e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 11 5.08e-01 -0.115000 7.08e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 60 1.24e-01 -0.115000 3.17e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 49 1.66e-01 -0.114000 3.77e-01
REACTOME GPCR DOWNSTREAM SIGNALING 116 3.52e-02 -0.114000 1.60e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 166 1.23e-02 -0.113000 9.67e-02
REACTOME G1 S TRANSITION 68 1.13e-01 0.111000 3.05e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 5.25e-01 0.111000 7.21e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS 13 4.94e-01 -0.110000 6.97e-01
REACTOME SIGNALING BY FGFR IN DISEASE 85 8.14e-02 -0.110000 2.49e-01
REACTOME PLATELET HOMEOSTASIS 36 2.56e-01 -0.110000 4.76e-01
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 16 4.50e-01 0.109000 6.64e-01
REACTOME SIGNALING BY ILS 72 1.11e-01 -0.109000 3.05e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 13 4.97e-01 0.109000 6.97e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 21 3.89e-01 0.109000 6.15e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 12 5.15e-01 0.109000 7.13e-01
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 23 3.69e-01 -0.108000 6.00e-01
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA 18 4.32e-01 -0.107000 6.52e-01
REACTOME RNA POL III CHAIN ELONGATION 16 4.61e-01 0.106000 6.73e-01
REACTOME MYOGENESIS 22 3.90e-01 0.106000 6.15e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 25 3.60e-01 -0.106000 5.91e-01
REACTOME TRNA AMINOACYLATION 39 2.55e-01 0.106000 4.76e-01
REACTOME AXON GUIDANCE 145 3.00e-02 -0.105000 1.48e-01
REACTOME LATE PHASE OF HIV LIFE CYCLE 86 9.51e-02 -0.104000 2.76e-01
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 16 4.70e-01 -0.104000 6.77e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 14 5.03e-01 -0.103000 7.04e-01
REACTOME MRNA CAPPING 28 3.46e-01 -0.103000 5.73e-01
REACTOME P38MAPK EVENTS 10 5.78e-01 0.102000 7.58e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM 16 4.82e-01 -0.101000 6.91e-01
REACTOME BOTULINUM NEUROTOXICITY 10 5.79e-01 -0.101000 7.58e-01
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS 10 5.79e-01 -0.101000 7.58e-01
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 16 4.86e-01 -0.101000 6.94e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 64 1.66e-01 -0.100000 3.77e-01
REACTOME OPIOID SIGNALLING 41 2.72e-01 -0.099300 4.90e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 11 5.72e-01 -0.098400 7.58e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 73 1.51e-01 0.097400 3.58e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 47 2.50e-01 -0.097100 4.73e-01
REACTOME G ALPHA1213 SIGNALLING EVENTS 45 2.62e-01 -0.096800 4.78e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 32 3.45e-01 -0.096600 5.73e-01
REACTOME DIABETES PATHWAYS 92 1.13e-01 -0.095800 3.05e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 17 4.96e-01 0.095500 6.97e-01
REACTOME PI3K CASCADE 47 2.63e-01 0.094500 4.78e-01
REACTOME PI METABOLISM 38 3.15e-01 -0.094300 5.41e-01
REACTOME SYNTHESIS OF DNA 62 2.03e-01 0.093600 4.15e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 49 2.58e-01 -0.093500 4.78e-01
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 21 4.59e-01 0.093300 6.72e-01
REACTOME PPARA ACTIVATES GENE EXPRESSION 81 1.48e-01 0.093300 3.55e-01
REACTOME PURINE SALVAGE 10 6.13e-01 -0.092500 7.82e-01
REACTOME G2 M CHECKPOINTS 17 5.17e-01 -0.090800 7.14e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 5.57e-01 -0.090600 7.51e-01
REACTOME RNA POL I TRANSCRIPTION 26 4.27e-01 -0.090000 6.52e-01
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING 22 4.66e-01 -0.089800 6.76e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 72 1.89e-01 -0.089700 4.03e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 32 3.81e-01 -0.089500 6.09e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 34 3.71e-01 -0.088700 6.01e-01
REACTOME SIGNALING BY NOTCH 77 1.85e-01 -0.087500 3.97e-01
REACTOME IRON UPTAKE AND TRANSPORT 23 4.69e-01 0.087300 6.77e-01
REACTOME GLOBAL GENOMIC NER GG NER 25 4.54e-01 -0.086500 6.69e-01
REACTOME S PHASE 72 2.07e-01 0.086200 4.18e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 46 3.19e-01 0.085000 5.44e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 16 5.58e-01 -0.084500 7.51e-01
REACTOME SIGNALING BY PDGF 87 1.77e-01 -0.084000 3.89e-01
REACTOME INSULIN SYNTHESIS AND PROCESSING 13 6.06e-01 -0.082700 7.80e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 15 5.80e-01 -0.082600 7.58e-01
REACTOME PYRIMIDINE METABOLISM 10 6.54e-01 0.081800 8.14e-01
REACTOME IMMUNE SYSTEM 557 1.25e-03 -0.081300 1.83e-02
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 11 6.46e-01 -0.080100 8.08e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS 13 6.18e-01 -0.080000 7.84e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 61 2.84e-01 0.079500 5.03e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 196 5.93e-02 0.078600 2.16e-01
REACTOME DEADENYLATION OF MRNA 16 5.87e-01 0.078400 7.65e-01
REACTOME FRS2 MEDIATED CASCADE 18 5.65e-01 -0.078400 7.58e-01
REACTOME GENERIC TRANSCRIPTION PATHWAY 139 1.12e-01 0.078400 3.05e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 5.46e-01 0.078000 7.39e-01
REACTOME PERK REGULATED GENE EXPRESSION 22 5.28e-01 -0.077900 7.22e-01
REACTOME SMOOTH MUSCLE CONTRACTION 18 5.68e-01 -0.077800 7.58e-01
REACTOME SIGNALING BY NOTCH1 52 3.34e-01 -0.077600 5.59e-01
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 82 2.30e-01 0.076800 4.50e-01
REACTOME SPRY REGULATION OF FGF SIGNALING 12 6.46e-01 -0.076600 8.08e-01
REACTOME ADAPTIVE IMMUNE SYSTEM 360 1.46e-02 -0.075700 1.06e-01
REACTOME SIGNALING BY RHO GTPASES 70 2.75e-01 -0.075600 4.93e-01
REACTOME RNA POL I TRANSCRIPTION TERMINATION 19 5.71e-01 -0.075000 7.58e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 46 3.84e-01 -0.074300 6.11e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 16 6.08e-01 0.074200 7.80e-01
REACTOME SIGNALING BY GPCR 159 1.14e-01 -0.072900 3.05e-01
REACTOME MITOTIC M M G1 PHASES 99 2.14e-01 0.072500 4.29e-01
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 18 6.13e-01 -0.069000 7.82e-01
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 179 1.22e-01 0.067300 3.16e-01
REACTOME SIGNAL TRANSDUCTION BY L1 28 5.41e-01 -0.066800 7.34e-01
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 13 6.79e-01 -0.066200 8.33e-01
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 37 4.89e-01 -0.065800 6.94e-01
REACTOME G ALPHA S SIGNALLING EVENTS 30 5.35e-01 -0.065500 7.28e-01
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 17 6.47e-01 0.064200 8.08e-01
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 17 6.47e-01 0.064200 8.08e-01
REACTOME CELL CELL JUNCTION ORGANIZATION 15 6.68e-01 -0.064100 8.25e-01
REACTOME TOLL RECEPTOR CASCADES 79 3.26e-01 -0.064100 5.50e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 24 5.88e-01 0.063900 7.65e-01
REACTOME SIGNALING BY INSULIN RECEPTOR 75 3.47e-01 0.062900 5.73e-01
REACTOME L1CAM INTERACTIONS 52 4.43e-01 -0.061600 6.56e-01
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 56 4.36e-01 -0.060300 6.52e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 57 4.34e-01 -0.060000 6.52e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS 16 6.82e-01 -0.059200 8.34e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES 17 6.75e-01 -0.058800 8.30e-01
REACTOME UNFOLDED PROTEIN RESPONSE 64 4.32e-01 -0.057000 6.52e-01
REACTOME DOUBLE STRAND BREAK REPAIR 13 7.23e-01 -0.056900 8.60e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 29 5.99e-01 0.056400 7.75e-01
REACTOME INSULIN RECEPTOR RECYCLING 15 7.06e-01 0.056300 8.48e-01
REACTOME SIGNALING BY ERBB2 69 4.29e-01 -0.055100 6.52e-01
REACTOME DEVELOPMENTAL BIOLOGY 245 1.40e-01 -0.055100 3.42e-01
REACTOME SHC MEDIATED CASCADE 11 7.56e-01 -0.054200 8.90e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 104 3.48e-01 -0.053400 5.73e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 28 6.26e-01 -0.053300 7.93e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 15 7.22e-01 0.053100 8.60e-01
REACTOME PHOSPHOLIPID METABOLISM 122 3.15e-01 -0.052900 5.41e-01
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 38 5.74e-01 0.052800 7.58e-01
REACTOME ION CHANNEL TRANSPORT 18 7.00e-01 -0.052400 8.48e-01
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 62 4.79e-01 -0.052000 6.88e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 10 7.76e-01 -0.051900 9.03e-01
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 58 4.97e-01 0.051600 6.97e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 54 5.21e-01 0.050600 7.18e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 11 7.75e-01 -0.049800 9.03e-01
REACTOME HIV INFECTION 158 2.91e-01 -0.048900 5.13e-01
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 21 7.04e-01 0.047900 8.48e-01
REACTOME HS GAG BIOSYNTHESIS 15 7.49e-01 0.047700 8.84e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS 25 6.84e-01 0.047100 8.34e-01
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 7.98e-01 0.046800 9.11e-01
REACTOME DNA REPLICATION 111 3.96e-01 0.046700 6.17e-01
REACTOME TIE2 SIGNALING 13 7.72e-01 -0.046400 9.02e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS 16 7.49e-01 0.046300 8.84e-01
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 61 5.35e-01 0.046000 7.28e-01
REACTOME PIP3 ACTIVATES AKT SIGNALING 25 6.93e-01 -0.045600 8.41e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 18 7.39e-01 -0.045400 8.77e-01
REACTOME METABOLISM OF CARBOHYDRATES 137 3.97e-01 0.042100 6.17e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 17 7.65e-01 0.042000 8.96e-01
REACTOME SHC MEDIATED SIGNALLING 13 7.96e-01 -0.041400 9.11e-01
REACTOME ER PHAGOSOME PATHWAY 50 6.17e-01 0.041000 7.84e-01
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 54 6.07e-01 0.040600 7.80e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS 13 8.05e-01 -0.039600 9.12e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 14 8.00e-01 -0.039200 9.11e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 19 7.82e-01 -0.036700 9.06e-01
REACTOME ARMS MEDIATED ACTIVATION 14 8.12e-01 0.036700 9.16e-01
REACTOME TRIF MEDIATED TLR3 SIGNALING 56 6.36e-01 0.036600 8.03e-01
REACTOME METABOLISM OF NUCLEOTIDES 49 6.58e-01 -0.036600 8.16e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 16 8.00e-01 -0.036500 9.11e-01
REACTOME ACTIVATION OF GENES BY ATF4 19 7.83e-01 -0.036500 9.06e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 18 7.90e-01 0.036200 9.11e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 42 6.93e-01 0.035200 8.41e-01
REACTOME NEURONAL SYSTEM 90 5.73e-01 0.034500 7.58e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 11 8.43e-01 -0.034500 9.39e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 12 8.49e-01 -0.031700 9.43e-01
REACTOME SHC RELATED EVENTS 14 8.38e-01 0.031600 9.35e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS 100 5.90e-01 0.031300 7.65e-01
REACTOME ENOS ACTIVATION AND REGULATION 12 8.52e-01 -0.031200 9.44e-01
REACTOME CELL CYCLE 220 4.32e-01 -0.031000 6.52e-01
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 52 7.03e-01 -0.030600 8.48e-01
REACTOME SIGNALLING BY NGF 160 5.11e-01 -0.030200 7.10e-01
REACTOME PLATELET CALCIUM HOMEOSTASIS 10 8.69e-01 0.030000 9.53e-01
REACTOME MITOTIC G1 G1 S PHASES 83 6.74e-01 0.026800 8.30e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 22 8.29e-01 0.026700 9.27e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 65 7.11e-01 -0.026600 8.52e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 33 7.97e-01 0.026000 9.11e-01
REACTOME ACTIVATED TLR4 SIGNALLING 66 7.17e-01 0.025800 8.57e-01
REACTOME PHOSPHORYLATION OF THE APC C 14 8.68e-01 0.025600 9.53e-01
REACTOME G0 AND EARLY G1 11 8.83e-01 -0.025600 9.56e-01
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 103 6.55e-01 -0.025500 8.14e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 13 8.76e-01 -0.025000 9.53e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM 10 8.91e-01 0.025000 9.62e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 58 7.58e-01 0.023400 8.90e-01
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 17 8.69e-01 0.023200 9.53e-01
REACTOME METABOLISM OF NON CODING RNA 42 7.96e-01 0.023100 9.11e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 39 8.05e-01 -0.022800 9.12e-01
REACTOME RNA POL III TRANSCRIPTION 31 8.27e-01 -0.022600 9.27e-01
REACTOME SOS MEDIATED SIGNALLING 13 8.95e-01 -0.021100 9.63e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 25 8.60e-01 -0.020400 9.51e-01
REACTOME MITOTIC G2 G2 M PHASES 49 8.15e-01 -0.019300 9.16e-01
REACTOME RNA POL I TRANSCRIPTION INITIATION 23 8.73e-01 -0.019200 9.53e-01
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS 25 8.71e-01 0.018800 9.53e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 15 9.06e-01 0.017600 9.72e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 14 9.11e-01 0.017300 9.73e-01
REACTOME SIGNALING BY ERBB4 67 8.15e-01 -0.016600 9.16e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI 15 9.17e-01 -0.015600 9.75e-01
REACTOME PROTEIN FOLDING 40 8.74e-01 0.014500 9.53e-01
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 19 9.17e-01 0.013800 9.75e-01
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 10 9.40e-01 -0.013800 9.88e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 43 8.83e-01 -0.012900 9.56e-01
REACTOME IL1 SIGNALING 27 9.24e-01 -0.010600 9.78e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 21 9.34e-01 0.010500 9.86e-01
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 30 9.22e-01 -0.010300 9.78e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS 16 9.45e-01 -0.009900 9.89e-01
REACTOME MITOTIC PROMETAPHASE 46 9.11e-01 -0.009500 9.73e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 11 9.58e-01 0.009260 9.89e-01
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 14 9.53e-01 -0.009080 9.89e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 22 9.42e-01 -0.009040 9.88e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 29 9.40e-01 0.008140 9.88e-01
REACTOME APOPTOSIS 102 8.92e-01 0.007780 9.62e-01
REACTOME SIGNALLING TO RAS 20 9.58e-01 0.006760 9.89e-01
REACTOME METAL ION SLC TRANSPORTERS 12 9.69e-01 -0.006570 9.89e-01
REACTOME PI3K AKT ACTIVATION 31 9.54e-01 -0.006040 9.89e-01
REACTOME NUCLEAR SIGNALING BY ERBB4 22 9.67e-01 0.005130 9.89e-01
REACTOME SIGNALLING TO ERKS 28 9.63e-01 -0.005060 9.89e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 25 9.66e-01 -0.004990 9.89e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 11 9.78e-01 -0.004730 9.89e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 14 9.80e-01 -0.003870 9.89e-01
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 25 9.74e-01 0.003720 9.89e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 17 9.80e-01 -0.003470 9.89e-01
REACTOME CELL JUNCTION ORGANIZATION 29 9.74e-01 0.003460 9.89e-01
REACTOME PURINE METABOLISM 27 9.80e-01 0.002740 9.89e-01
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 20 9.84e-01 -0.002640 9.90e-01
REACTOME GPCR LIGAND BINDING 44 9.79e-01 -0.002280 9.89e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 12 9.89e-01 -0.002210 9.93e-01
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 289 9.52e-01 -0.002060 9.89e-01
REACTOME ERKS ARE INACTIVATED 11 9.91e-01 0.002030 9.93e-01
REACTOME CELL CYCLE MITOTIC 192 9.73e-01 -0.001410 9.89e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS 12 9.96e-01 -0.000807 9.96e-01


Detailed Gene set reports



REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
414
set REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
setSize 12
pANOVA 8.01e-07
s.dist 0.823
p.adjustANOVA 3.14e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5k 4932
Atp5c1 4840
Atp5h 4750
Atp5l 4715
Atp5j2 4561
Atp5j 4083
Atp5b 4068
Atp5d 4021
Atp5g1 3957
Atp5e 3770
Atp5a1 2948
Atp5o 2413

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5k 4932
Atp5c1 4840
Atp5h 4750
Atp5l 4715
Atp5j2 4561
Atp5j 4083
Atp5b 4068
Atp5d 4021
Atp5g1 3957
Atp5e 3770
Atp5a1 2948
Atp5o 2413


REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
408
set REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
setSize 73
pANOVA 9.13e-22
s.dist 0.649
p.adjustANOVA 2.15e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5k 4932
Cox6c 4900
Etfdh 4870
Atp5c1 4840
Ndufa5 4837
Ndufa4 4834
Cox7c 4806
Cycs 4767
Atp5h 4750
Atp5l 4715
Sdhd 4666
Ndufb9 4636
Sdhb 4623
Etfb 4620
Ndufs6 4588
Atp5j2 4561
Ndufs4 4549
Ndufa2 4548
Ndufb2 4542
Ndufs1 4521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5k 4932
Cox6c 4900
Etfdh 4870
Atp5c1 4840
Ndufa5 4837
Ndufa4 4834
Cox7c 4806
Cycs 4767
Atp5h 4750
Atp5l 4715
Sdhd 4666
Ndufb9 4636
Sdhb 4623
Etfb 4620
Ndufs6 4588
Atp5j2 4561
Ndufs4 4549
Ndufa2 4548
Ndufb2 4542
Ndufs1 4521
Ndufb5 4492
Uqcrh 4460
Uqcrfs1 4443
Ndufs5 4431
Ndufc2 4412
Uqcrq 4294
Cox6b1 4258
Ndufa6 4218
Uqcrb 4203
Etfa 4161
Ndufb4 4117
Atp5j 4083
Atp5b 4068
Ndufv2 4042
Uqcrc1 4032
Atp5d 4021
Atp5g1 3957
Ndufa12 3940
Ndufa10 3925
Atp5e 3770
Ndufa7 3722
Ndufa9 3718
Ndufb10 3495
Uqcr11 3467
Ndufa1 3432
Ndufb7 3371
Ndufab1 3293
Ndufv1 3108
Ndufs2 3034
Ndufa11 2993
Ndufb3 2969
Atp5a1 2948
Ndufs3 2939
Uqcrc2 2858
Sdhc 2779
Ndufa8 2434
Atp5o 2413
Ndufc1 2311
Ndufs7 2274
Ndufv3 2259
Sdha 2192
Ucp3 2156
Ndufs8 2152
Cox5a 1611
Cyc1 1503
Ndufa13 1127
Ndufa3 -279
Ndufb6 -546
Cox7a2l -626
Cox6a1 -1102
Cox4i1 -1175
Cox8a -4207
Ucp2 -4690


REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
334
set REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
setSize 59
pANOVA 1.31e-17
s.dist 0.643
p.adjustANOVA 2.05e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cox6c 4900
Etfdh 4870
Ndufa5 4837
Ndufa4 4834
Cox7c 4806
Cycs 4767
Sdhd 4666
Ndufb9 4636
Sdhb 4623
Etfb 4620
Ndufs6 4588
Ndufs4 4549
Ndufa2 4548
Ndufb2 4542
Ndufs1 4521
Ndufb5 4492
Uqcrh 4460
Uqcrfs1 4443
Ndufs5 4431
Ndufc2 4412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cox6c 4900
Etfdh 4870
Ndufa5 4837
Ndufa4 4834
Cox7c 4806
Cycs 4767
Sdhd 4666
Ndufb9 4636
Sdhb 4623
Etfb 4620
Ndufs6 4588
Ndufs4 4549
Ndufa2 4548
Ndufb2 4542
Ndufs1 4521
Ndufb5 4492
Uqcrh 4460
Uqcrfs1 4443
Ndufs5 4431
Ndufc2 4412
Uqcrq 4294
Cox6b1 4258
Ndufa6 4218
Uqcrb 4203
Etfa 4161
Ndufb4 4117
Ndufv2 4042
Uqcrc1 4032
Ndufa12 3940
Ndufa10 3925
Ndufa7 3722
Ndufa9 3718
Ndufb10 3495
Uqcr11 3467
Ndufa1 3432
Ndufb7 3371
Ndufab1 3293
Ndufv1 3108
Ndufs2 3034
Ndufa11 2993
Ndufb3 2969
Ndufs3 2939
Uqcrc2 2858
Sdhc 2779
Ndufa8 2434
Ndufc1 2311
Ndufs7 2274
Ndufv3 2259
Sdha 2192
Ndufs8 2152
Cox5a 1611
Cyc1 1503
Ndufa13 1127
Ndufa3 -279
Ndufb6 -546
Cox7a2l -626
Cox6a1 -1102
Cox4i1 -1175
Cox8a -4207


REACTOME_PYRUVATE_METABOLISM

REACTOME_PYRUVATE_METABOLISM
293
set REACTOME_PYRUVATE_METABOLISM
setSize 16
pANOVA 2.35e-05
s.dist 0.611
p.adjustANOVA 0.000693



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc16a1 4915
Pdk4 4638
Bsg 4517
Pdha1 4513
Slc16a3 4361
Dld 4144
Pdpr 4134
Pdp1 3986
Pdhb 3521
Pdhx 3258
Pdk1 3253
Dlat 3162
Pdk2 1913
Ldhb 1802
Ldha 784
Pdp2 -3983

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc16a1 4915
Pdk4 4638
Bsg 4517
Pdha1 4513
Slc16a3 4361
Dld 4144
Pdpr 4134
Pdp1 3986
Pdhb 3521
Pdhx 3258
Pdk1 3253
Dlat 3162
Pdk2 1913
Ldhb 1802
Ldha 784
Pdp2 -3983


REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
24
set REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
setSize 107
pANOVA 9.33e-27
s.dist 0.599
p.adjustANOVA 4.39e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5k 4932
Slc16a1 4915
Cox6c 4900
Etfdh 4870
Atp5c1 4840
Ndufa5 4837
Ndufa4 4834
Cox7c 4806
Cycs 4767
Atp5h 4750
Atp5l 4715
Sdhd 4666
Pdk4 4638
Ndufb9 4636
Sdhb 4623
Etfb 4620
Ndufs6 4588
Atp5j2 4561
Ndufs4 4549
Ndufa2 4548

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5k 4932
Slc16a1 4915
Cox6c 4900
Etfdh 4870
Atp5c1 4840
Ndufa5 4837
Ndufa4 4834
Cox7c 4806
Cycs 4767
Atp5h 4750
Atp5l 4715
Sdhd 4666
Pdk4 4638
Ndufb9 4636
Sdhb 4623
Etfb 4620
Ndufs6 4588
Atp5j2 4561
Ndufs4 4549
Ndufa2 4548
Ndufb2 4542
Ndufs1 4521
Bsg 4517
Pdha1 4513
Ndufb5 4492
Uqcrh 4460
Uqcrfs1 4443
Ndufs5 4431
Ndufc2 4412
Slc16a3 4361
Uqcrq 4294
Cox6b1 4258
Ndufa6 4218
Uqcrb 4203
Etfa 4161
Dld 4144
Pdpr 4134
Ndufb4 4117
Atp5j 4083
Atp5b 4068
Aco2 4062
Ndufv2 4042
Uqcrc1 4032
Sucla2 4024
Atp5d 4021
Pdp1 3986
Mdh2 3964
Atp5g1 3957
Ndufa12 3940
Ndufa10 3925
Atp5e 3770
Idh3a 3768
Ndufa7 3722
Ndufa9 3718
Fh1 3656
Pdhb 3521
Ndufb10 3495
Uqcr11 3467
Ndufa1 3432
Ndufb7 3371
Ndufab1 3293
Pdhx 3258
Pdk1 3253
Idh3b 3245
Dlat 3162
Ndufv1 3108
Dlst 3103
Ndufs2 3034
Ndufa11 2993
Ndufb3 2969
Atp5a1 2948
Ndufs3 2939
Uqcrc2 2858
Sdhc 2779
L2hgdh 2737
Idh3g 2704
Ogdh 2648
Suclg2 2567
Ndufa8 2434
Atp5o 2413
Ndufc1 2311
Ndufs7 2274
Ndufv3 2259
Sdha 2192
Ucp3 2156
Ndufs8 2152
Idh2 2111
Pdk2 1913
Cs 1875
Ldhb 1802
Cox5a 1611
Cyc1 1503
Ndufa13 1127
Ldha 784
Suclg1 420
Ndufa3 -279
Ndufb6 -546
Cox7a2l -626
Adhfe1 -1074
Cox6a1 -1102
Cox4i1 -1175
Idh1 -1614
D2hgdh -1776
Nnt -2358
Pdp2 -3983
Cox8a -4207
Ucp2 -4690


REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
137
set REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
setSize 11
pANOVA 0.000706
s.dist 0.59
p.adjustANOVA 0.0119



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pdk4 4638
Pdha1 4513
Dld 4144
Pdpr 4134
Pdp1 3986
Pdhb 3521
Pdhx 3258
Pdk1 3253
Dlat 3162
Pdk2 1913
Pdp2 -3983

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdk4 4638
Pdha1 4513
Dld 4144
Pdpr 4134
Pdp1 3986
Pdhb 3521
Pdhx 3258
Pdk1 3253
Dlat 3162
Pdk2 1913
Pdp2 -3983


REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
224
set REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
setSize 19
pANOVA 1.79e-05
s.dist 0.569
p.adjustANOVA 0.000562



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sdhd 4666
Sdhb 4623
Dld 4144
Aco2 4062
Sucla2 4024
Mdh2 3964
Idh3a 3768
Fh1 3656
Idh3b 3245
Dlst 3103
Sdhc 2779
Idh3g 2704
Ogdh 2648
Suclg2 2567
Sdha 2192
Idh2 2111
Cs 1875
Suclg1 420
Nnt -2358

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sdhd 4666
Sdhb 4623
Dld 4144
Aco2 4062
Sucla2 4024
Mdh2 3964
Idh3a 3768
Fh1 3656
Idh3b 3245
Dlst 3103
Sdhc 2779
Idh3g 2704
Ogdh 2648
Suclg2 2567
Sdha 2192
Idh2 2111
Cs 1875
Suclg1 420
Nnt -2358


REACTOME_COMPLEMENT_CASCADE

REACTOME_COMPLEMENT_CASCADE
433
set REACTOME_COMPLEMENT_CASCADE
setSize 10
pANOVA 0.00199
s.dist -0.565
p.adjustANOVA 0.0276



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cfd -4767
C1qa -4301
C3 -4245
Cr1l -4219
C1qc -4150
C1qb -4110
C4b -4059
C1s1 -336
Pros1 671
C7 3024

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cfd -4767
C1qa -4301
C3 -4245
Cr1l -4219
C1qc -4150
C1qb -4110
C4b -4059
C1s1 -336
Pros1 671
C7 3024


REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS
72
set REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS
setSize 22
pANOVA 1.41e-05
s.dist -0.535
p.adjustANOVA 0.000476



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3ap1 -4658
Pik3cd -4637
Syk -4621
Itpr3 -4597
Cd79b -4585
Cd19 -4348
Cd79a -4274
Cbl -4268
Lyn -4120
Pik3r1 -4097
Plcg1 -4039
Grb2 -3931
Nck1 -3682
Shc1 -2680
Sh3kbp1 -2085
Itpr2 -1147
Fyn -974
Calm1 468
Sos1 925
Orai1 1711

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3ap1 -4658
Pik3cd -4637
Syk -4621
Itpr3 -4597
Cd79b -4585
Cd19 -4348
Cd79a -4274
Cbl -4268
Lyn -4120
Pik3r1 -4097
Plcg1 -4039
Grb2 -3931
Nck1 -3682
Shc1 -2680
Sh3kbp1 -2085
Itpr2 -1147
Fyn -974
Calm1 468
Sos1 925
Orai1 1711
Stim1 2117
Cblb 2502


REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
170
set REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize 13
pANOVA 0.000905
s.dist 0.532
p.adjustANOVA 0.0138



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eci1 4518
Acadm 4505
Decr1 4455
Hadh 4453
Mcee 4235
Acadvl 4088
Acadl 4045
Hadha 3172
Echs1 1867
Hadhb 986
Pccb 425
Pcca -8
Acads -1967

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eci1 4518
Acadm 4505
Decr1 4455
Hadh 4453
Mcee 4235
Acadvl 4088
Acadl 4045
Hadha 3172
Echs1 1867
Hadhb 986
Pccb 425
Pcca -8
Acads -1967


REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
345
set REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
setSize 13
pANOVA 0.00146
s.dist -0.51
p.adjustANOVA 0.0208



Top enriched genes

Top 20 genes
GeneID Gene Rank
Edem1 -4599
Prkcsh -4354
Calr -4121
Man1b1 -3891
Canx -3644
Pdia3 -3201
Edem2 -2844
Uggt1 -2824
Mlec -2799
Mogs -2621
Ganab -2153
Uggt2 2933
Edem3 3141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem1 -4599
Prkcsh -4354
Calr -4121
Man1b1 -3891
Canx -3644
Pdia3 -3201
Edem2 -2844
Uggt1 -2824
Mlec -2799
Mogs -2621
Ganab -2153
Uggt2 2933
Edem3 3141


REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
5
set REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
setSize 38
pANOVA 5.69e-08
s.dist 0.509
p.adjustANOVA 2.44e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc16a1 4915
Sdhd 4666
Pdk4 4638
Sdhb 4623
Bsg 4517
Pdha1 4513
Slc16a3 4361
Dld 4144
Pdpr 4134
Aco2 4062
Sucla2 4024
Pdp1 3986
Mdh2 3964
Idh3a 3768
Fh1 3656
Pdhb 3521
Pdhx 3258
Pdk1 3253
Idh3b 3245
Dlat 3162

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc16a1 4915
Sdhd 4666
Pdk4 4638
Sdhb 4623
Bsg 4517
Pdha1 4513
Slc16a3 4361
Dld 4144
Pdpr 4134
Aco2 4062
Sucla2 4024
Pdp1 3986
Mdh2 3964
Idh3a 3768
Fh1 3656
Pdhb 3521
Pdhx 3258
Pdk1 3253
Idh3b 3245
Dlat 3162
Dlst 3103
Sdhc 2779
L2hgdh 2737
Idh3g 2704
Ogdh 2648
Suclg2 2567
Sdha 2192
Idh2 2111
Pdk2 1913
Cs 1875
Ldhb 1802
Ldha 784
Suclg1 420
Adhfe1 -1074
Idh1 -1614
D2hgdh -1776
Nnt -2358
Pdp2 -3983


REACTOME_PEPTIDE_CHAIN_ELONGATION

REACTOME_PEPTIDE_CHAIN_ELONGATION
168
set REACTOME_PEPTIDE_CHAIN_ELONGATION
setSize 67
pANOVA 8.26e-13
s.dist -0.506
p.adjustANOVA 9.73e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eef1a1 -4737
Rpl3 -4706
Rpl12 -4664
Rps3 -4613
Rps6 -4508
Rpl11 -4496
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rpl18a -4328
Rpl5 -4205
Rps9 -4204
Rplp0 -4122
Rpl37a -4109
Rpl30 -4102
Rpl8 -4099
Rps3a1 -4063
Rps8 -4062
Rpl38 -4020
Rps24 -3987

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eef1a1 -4737.0
Rpl3 -4706.0
Rpl12 -4664.0
Rps3 -4613.0
Rps6 -4508.0
Rpl11 -4496.0
Rps4x -4476.0
Rps7 -4463.0
Rps18 -4428.0
Rpl18a -4328.0
Rpl5 -4205.0
Rps9 -4204.0
Rplp0 -4122.0
Rpl37a -4109.0
Rpl30 -4102.0
Rpl8 -4099.0
Rps3a1 -4063.0
Rps8 -4062.0
Rpl38 -4020.0
Rps24 -3987.0
Rps23 -3948.0
Rps16 -3928.0
Rpl6 -3907.0
Rps20 -3879.0
Rps13 -3742.0
Rpsa -3686.0
Rps25 -3603.0
Rplp2 -3535.0
Rps26 -3489.0
Rpl14 -3484.0
Rpl28 -3471.0
Rps15a -3365.0
Rpl23 -3347.0
Rps11 -3099.0
Rpl26 -3053.0
Rpl13 -2756.0
Rps14 -2751.0
Rpl4 -2436.0
Rpl15 -2333.0
Rpl18 -2246.0
Rps5 -2186.0
Rpl32 -2111.0
Rpl22 -2109.0
Eef2 -2019.0
Rpl34 -1902.0
Rpl10a -1894.0
Rpl23a -1819.0
Rps12-ps3 -1676.0
Rpl19 -1606.0
Rpl29 -1550.0
Rps19 -1015.0
Rpl37 -885.0
Rpl27a -765.0
Rpl41 -569.0
Rps27 -456.0
Rps27a -418.0
Rplp1 -401.0
Rpl36al -390.0
Rpl35 -260.0
Rps21 -163.0
Rps17 744.0
Rpl27-ps3 1035.5
Rpl24 2028.0
Rpl39 2029.0
Rpl3l 4079.0
Uba52 4621.0
Rps29 4695.0


REACTOME_CALNEXIN_CALRETICULIN_CYCLE

REACTOME_CALNEXIN_CALRETICULIN_CYCLE
341
set REACTOME_CALNEXIN_CALRETICULIN_CYCLE
setSize 11
pANOVA 0.00427
s.dist -0.498
p.adjustANOVA 0.0468



Top enriched genes

Top 20 genes
GeneID Gene Rank
Edem1 -4599
Prkcsh -4354
Calr -4121
Man1b1 -3891
Canx -3644
Pdia3 -3201
Edem2 -2844
Uggt1 -2824
Ganab -2153
Uggt2 2933
Edem3 3141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem1 -4599
Prkcsh -4354
Calr -4121
Man1b1 -3891
Canx -3644
Pdia3 -3201
Edem2 -2844
Uggt1 -2824
Ganab -2153
Uggt2 2933
Edem3 3141


REACTOME_G_PROTEIN_ACTIVATION

REACTOME_G_PROTEIN_ACTIVATION
189
set REACTOME_G_PROTEIN_ACTIVATION
setSize 10
pANOVA 0.0144
s.dist -0.447
p.adjustANOVA 0.106



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gnai2 -4502
Gnb4 -3608
Gnai3 -3113
Gng12 -2886
Gnb2 -2386
Gnao1 -2302
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gng5 1271

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnai2 -4502
Gnb4 -3608
Gnai3 -3113
Gng12 -2886
Gnb2 -2386
Gnao1 -2302
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gng5 1271


REACTOME_TCR_SIGNALING

REACTOME_TCR_SIGNALING
136
set REACTOME_TCR_SIGNALING
setSize 30
pANOVA 2.8e-05
s.dist -0.442
p.adjustANOVA 0.000738



Top enriched genes

Top 20 genes
GeneID Gene Rank
Csk -4760
H2-Eb1 -4708
Vasp -4691
H2-Aa -4684
Ptprc -4561
Pag1 -4517
Evl -4277
Ikbkb -4135
Pik3r1 -4097
Plcg1 -4039
Pak2 -3804
Nck1 -3682
Traf6 -3511
Bcl10 -3087
Rela -3065
Malt1 -2401
Pak1 -2175
Nfkbia -2126
Pten -1997
Pdpk1 -1811

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Csk -4760
H2-Eb1 -4708
Vasp -4691
H2-Aa -4684
Ptprc -4561
Pag1 -4517
Evl -4277
Ikbkb -4135
Pik3r1 -4097
Plcg1 -4039
Pak2 -3804
Nck1 -3682
Traf6 -3511
Bcl10 -3087
Rela -3065
Malt1 -2401
Pak1 -2175
Nfkbia -2126
Pten -1997
Pdpk1 -1811
Tab2 -1758
Chuk -1574
Pik3ca -534
Prkcq 788
Gm20431 976
Ikbkg 1303
Map3k7 1688
Pik3r2 2281
Enah 3325
Pik3cb 4153


REACTOME_METABOLISM_OF_POLYAMINES

REACTOME_METABOLISM_OF_POLYAMINES
173
set REACTOME_METABOLISM_OF_POLYAMINES
setSize 13
pANOVA 0.00615
s.dist 0.439
p.adjustANOVA 0.0591



Top enriched genes

Top 20 genes
GeneID Gene Rank
Odc1 4611
Srm 4599
Got1 4498
Smox 4335
Sms 4286
Mtap 4225
Mri1 4037
Apip 3064
Adi1 1462
Paox 362
Amd1 -1017
Enoph1 -1544
Sat1 -3992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Odc1 4611
Srm 4599
Got1 4498
Smox 4335
Sms 4286
Mtap 4225
Mri1 4037
Apip 3064
Adi1 1462
Paox 362
Amd1 -1017
Enoph1 -1544
Sat1 -3992


REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC

REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
445
set REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
setSize 15
pANOVA 0.00436
s.dist -0.425
p.adjustANOVA 0.0468



Top enriched genes

Top 20 genes
GeneID Gene Rank
B2m -4584
Tap2 -4543
Calr -4121
Hspa5 -3861
Sec24d -3826
Tap1 -3691
Canx -3644
Pdia3 -3201
Erap1 -3142
Sec24b -563
Sec13 -413
Sec31a -226
Sec24c 101
Sar1b 1600
Sec23a 4551

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B2m -4584
Tap2 -4543
Calr -4121
Hspa5 -3861
Sec24d -3826
Tap1 -3691
Canx -3644
Pdia3 -3201
Erap1 -3142
Sec24b -563
Sec13 -413
Sec31a -226
Sec24c 101
Sar1b 1600
Sec23a 4551


REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS
320
set REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS
setSize 15
pANOVA 0.0058
s.dist -0.412
p.adjustANOVA 0.0581



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rasgrp2 -4656
Itpr3 -4597
Dgka -4577
Prkcd -4338
Prkch -4043
Dgkd -2605
Dgkh -2433
Daglb -1533
Dgke -1374
Mgll -1336
Itpr2 -1147
Dagla 514
Dgkq 705
Prkcq 788
Prkce 2063

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rasgrp2 -4656
Itpr3 -4597
Dgka -4577
Prkcd -4338
Prkch -4043
Dgkd -2605
Dgkh -2433
Daglb -1533
Dgke -1374
Mgll -1336
Itpr2 -1147
Dagla 514
Dgkq 705
Prkcq 788
Prkce 2063


REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE

REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
57
set REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
setSize 89
pANOVA 2.47e-11
s.dist -0.41
p.adjustANOVA 2.32e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl3 -4706
Rpl12 -4664
Rps3 -4613
Rps6 -4508
Rpl11 -4496
Rps4x -4476
Rps7 -4463
Rps18 -4428
Sec61a1 -4367
Rpl18a -4328
Rpl5 -4205
Rps9 -4204
Sec61g -4178
Rplp0 -4122
Rpl37a -4109
Rpl30 -4102
Rpl8 -4099
Rps3a1 -4063
Rps8 -4062
Rpl38 -4020

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl3 -4706.0
Rpl12 -4664.0
Rps3 -4613.0
Rps6 -4508.0
Rpl11 -4496.0
Rps4x -4476.0
Rps7 -4463.0
Rps18 -4428.0
Sec61a1 -4367.0
Rpl18a -4328.0
Rpl5 -4205.0
Rps9 -4204.0
Sec61g -4178.0
Rplp0 -4122.0
Rpl37a -4109.0
Rpl30 -4102.0
Rpl8 -4099.0
Rps3a1 -4063.0
Rps8 -4062.0
Rpl38 -4020.0
Rps24 -3987.0
Rps23 -3948.0
Rps16 -3928.0
Tram1 -3916.0
Rpl6 -3907.0
Rps20 -3879.0
Rps13 -3742.0
Sec61a2 -3733.0
Sec11c -3718.0
Rpsa -3686.0
Rps25 -3603.0
Rplp2 -3535.0
Rps26 -3489.0
Rpl14 -3484.0
Rpl28 -3471.0
Rps15a -3365.0
Rpl23 -3347.0
Ssr4 -3331.0
Rps11 -3099.0
Rpl26 -3053.0
Ssr2 -3051.0
Rpn2 -2867.0
Rpl13 -2756.0
Rps14 -2751.0
Spcs3 -2660.0
Srp68 -2440.0
Rpl4 -2436.0
Rpl15 -2333.0
Rpl18 -2246.0
Rps5 -2186.0
Srp9 -2145.0
Rpl32 -2111.0
Rpl22 -2109.0
Rpl34 -1902.0
Rpl10a -1894.0
Rpl23a -1819.0
Rps12-ps3 -1676.0
Rpl19 -1606.0
Ssr1 -1599.0
Rpl29 -1550.0
Srp14 -1428.0
Srprb -1186.0
Rps19 -1015.0
Rpl37 -885.0
Rpl27a -765.0
Rpl41 -569.0
Rps27 -456.0
Rps27a -418.0
Rplp1 -401.0
Rpl36al -390.0
Rpl35 -260.0
Sec11a -223.0
Rps21 -163.0
Sec61b 265.0
Rps17 744.0
Ddost 753.0
Rpl27-ps3 1035.5
Srp72 1214.0
Srp19 1749.0
Rpl24 2028.0
Rpl39 2029.0
Spcs2 2500.0
Rpl3l 4079.0
Spcs1 4097.0
Srp54a 4383.0
Ssr3 4530.0
Rpn1 4543.0
Uba52 4621.0
Rps29 4695.0


REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
9
set REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
setSize 42
pANOVA 4.97e-06
s.dist -0.407
p.adjustANOVA 0.00018



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps3 -4613
Rps6 -4508
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rps9 -4204
Rps3a1 -4063
Rps8 -4062
Rps24 -3987
Rps23 -3948
Rps16 -3928
Rps20 -3879
Rps13 -3742
Rpsa -3686
Rps25 -3603
Rps26 -3489
Eif3k -3419
Rps15a -3365
Eif3f -3228
Rps11 -3099

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps3 -4613
Rps6 -4508
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rps9 -4204
Rps3a1 -4063
Rps8 -4062
Rps24 -3987
Rps23 -3948
Rps16 -3928
Rps20 -3879
Rps13 -3742
Rpsa -3686
Rps25 -3603
Rps26 -3489
Eif3k -3419
Rps15a -3365
Eif3f -3228
Rps11 -3099
Rps14 -2751
Eif3b -2694
Eif3h -2634
Eif2s3x -2463
Rps5 -2186
Rps12-ps3 -1676
Eif1ax -1642
Eif3e -1454
Rps19 -1015
Eif3d -826
Eif3g -775
Rps27 -456
Rps27a -418
Eif3c -358
Rps21 -163
Rps17 744
Eif3j2 1754
Eif3i 2584
Eif3a 3198
Eif2s1 3526
Eif2s2 4274
Rps29 4695


REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
400
set REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
setSize 83
pANOVA 1.48e-10
s.dist -0.407
p.adjustANOVA 1.16e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl3 -4706
Rpl12 -4664
Rps3 -4613
Rps6 -4508
Rpl11 -4496
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rpl18a -4328
Rpl5 -4205
Rps9 -4204
Rplp0 -4122
Rpl37a -4109
Rpl30 -4102
Rpl8 -4099
Rps3a1 -4063
Rps8 -4062
Polr2a -4055
Rpl38 -4020
Rps24 -3987

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl3 -4706.0
Rpl12 -4664.0
Rps3 -4613.0
Rps6 -4508.0
Rpl11 -4496.0
Rps4x -4476.0
Rps7 -4463.0
Rps18 -4428.0
Rpl18a -4328.0
Rpl5 -4205.0
Rps9 -4204.0
Rplp0 -4122.0
Rpl37a -4109.0
Rpl30 -4102.0
Rpl8 -4099.0
Rps3a1 -4063.0
Rps8 -4062.0
Polr2a -4055.0
Rpl38 -4020.0
Rps24 -3987.0
Rps23 -3948.0
Rps16 -3928.0
Rpl6 -3907.0
Rps20 -3879.0
Rps13 -3742.0
Rpsa -3686.0
Rps25 -3603.0
Rplp2 -3535.0
Rps26 -3489.0
Rpl14 -3484.0
Rpl28 -3471.0
Rps15a -3365.0
Rpl23 -3347.0
Polr2h -3277.0
Polr2g -3267.0
Rps11 -3099.0
Rpl26 -3053.0
Polr2f -2963.0
Polr2b -2820.0
Rpl13 -2756.0
Polr2e -2755.0
Rps14 -2751.0
Polr2j -2499.0
Rpl4 -2436.0
Rpl15 -2333.0
Rpl18 -2246.0
Gtf2f2 -2196.0
Rps5 -2186.0
Rpl32 -2111.0
Rpl22 -2109.0
Rpl34 -1902.0
Rpl10a -1894.0
Rpl23a -1819.0
Rps12-ps3 -1676.0
Rpl19 -1606.0
Rpl29 -1550.0
Rps19 -1015.0
Rpl37 -885.0
Polr2c -851.0
Rpl27a -765.0
Rpl41 -569.0
Rps27 -456.0
Rps27a -418.0
Rplp1 -401.0
Rpl36al -390.0
Rpl35 -260.0
Rps21 -163.0
Gtf2f1 447.0
Rps17 744.0
Dnajc3 849.0
Rpl27-ps3 1035.5
Polr2l 1527.0
Ipo5 1817.0
Rpl24 2028.0
Rpl39 2029.0
Polr2d 2488.0
Hsp90aa1 2636.0
Polr2i 2986.0
Polr2k 3181.0
Rpl3l 4079.0
Grsf1 4158.0
Uba52 4621.0
Rps29 4695.0


REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS

REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
390
set REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
setSize 11
pANOVA 0.022
s.dist -0.399
p.adjustANOVA 0.13



Top enriched genes

Top 20 genes
GeneID Gene Rank
Plin1 -4745
Lipe -4576
Fabp4 -4446
Prkacb -4339
Ppp1ca -1608
Ppp1cb -1546
Mgll -1336
Cav1 -577
Ppp1cc -574
Prkaca 1048
Abhd5 2418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plin1 -4745
Lipe -4576
Fabp4 -4446
Prkacb -4339
Ppp1ca -1608
Ppp1cb -1546
Mgll -1336
Cav1 -577
Ppp1cc -574
Prkaca 1048
Abhd5 2418


REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX

REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
447
set REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
setSize 85
pANOVA 7.92e-10
s.dist -0.386
p.adjustANOVA 5.33e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl3 -4706
Rpl12 -4664
Rps3 -4613
Rps6 -4508
Rpl11 -4496
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rpl18a -4328
Rpl5 -4205
Rps9 -4204
Rplp0 -4122
Rpl37a -4109
Rpl30 -4102
Rpl8 -4099
Rps3a1 -4063
Rps8 -4062
Rpl38 -4020
Rps24 -3987
Rps23 -3948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl3 -4706.0
Rpl12 -4664.0
Rps3 -4613.0
Rps6 -4508.0
Rpl11 -4496.0
Rps4x -4476.0
Rps7 -4463.0
Rps18 -4428.0
Rpl18a -4328.0
Rpl5 -4205.0
Rps9 -4204.0
Rplp0 -4122.0
Rpl37a -4109.0
Rpl30 -4102.0
Rpl8 -4099.0
Rps3a1 -4063.0
Rps8 -4062.0
Rpl38 -4020.0
Rps24 -3987.0
Rps23 -3948.0
Rps16 -3928.0
Rpl6 -3907.0
Rps20 -3879.0
Smg7 -3777.0
Rps13 -3742.0
Rpsa -3686.0
Rps25 -3603.0
Rplp2 -3535.0
Rps26 -3489.0
Rpl14 -3484.0
Rpl28 -3471.0
Eif4a3 -3377.0
Upf3b -3366.0
Rps15a -3365.0
Rpl23 -3347.0
Rps11 -3099.0
Rpl26 -3053.0
Smg8 -2998.0
Rnps1 -2968.0
Rpl13 -2756.0
Rps14 -2751.0
Ppp2ca -2695.0
Rpl4 -2436.0
Rpl15 -2333.0
Rpl18 -2246.0
Rps5 -2186.0
Smg6 -2156.0
Upf3a -2146.0
Rpl32 -2111.0
Rpl22 -2109.0
Rpl34 -1902.0
Rpl10a -1894.0
Rpl23a -1819.0
Rps12-ps3 -1676.0
Rpl19 -1606.0
Rpl29 -1550.0
Upf2 -1027.0
Rps19 -1015.0
Rpl37 -885.0
Ncbp1 -868.0
Rpl27a -765.0
Ppp2r2a -662.0
Rpl41 -569.0
Smg1 -538.0
Rps27 -456.0
Rps27a -418.0
Rplp1 -401.0
Rpl36al -390.0
Rpl35 -260.0
Rps21 -163.0
Rps17 744.0
Rpl27-ps3 1035.5
Magoh 1619.0
Rpl24 2028.0
Rpl39 2029.0
Casc3 2995.0
Eif4g1 3133.0
Smg9 3342.0
Ppp2r1a 3475.0
Ncbp2 3823.0
Etf1 4050.0
Rpl3l 4079.0
Smg5 4501.0
Uba52 4621.0
Rps29 4695.0


REACTOME_INTERFERON_GAMMA_SIGNALING

REACTOME_INTERFERON_GAMMA_SIGNALING
365
set REACTOME_INTERFERON_GAMMA_SIGNALING
setSize 32
pANOVA 0.00018
s.dist -0.383
p.adjustANOVA 0.00405



Top enriched genes

Top 20 genes
GeneID Gene Rank
Vcam1 -4744
Ciita -4738
H2-Eb1 -4708
Ptpn6 -4695
H2-Aa -4684
Irf8 -4655
B2m -4584
Pml -4485
Irf9 -4402
Prkcd -4338
Stat1 -4322
Ptpn1 -3863
Irf5 -3755
Camk2d -3230
Gbp7 -3132
Irf7 -2990
Ifngr1 -2719
Icam1 -2648
Ptpn2 -2127
Ifngr2 -1958

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Vcam1 -4744
Ciita -4738
H2-Eb1 -4708
Ptpn6 -4695
H2-Aa -4684
Irf8 -4655
B2m -4584
Pml -4485
Irf9 -4402
Prkcd -4338
Stat1 -4322
Ptpn1 -3863
Irf5 -3755
Camk2d -3230
Gbp7 -3132
Irf7 -2990
Ifngr1 -2719
Icam1 -2648
Ptpn2 -2127
Ifngr2 -1958
Pias1 -1457
Irf2 -982
Socs1 -307
Sumo1 -168
Irf1 238
Jak1 1030
Camk2b 2615
Camk2a 2756
Irf3 3459
Cd44 3557
Jak2 4815
Socs3 4859


REACTOME_GLUTATHIONE_CONJUGATION

REACTOME_GLUTATHIONE_CONJUGATION
432
set REACTOME_GLUTATHIONE_CONJUGATION
setSize 12
pANOVA 0.0263
s.dist 0.371
p.adjustANOVA 0.139



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gss 4426
Gsto1 4175
Gstm4 3733
Mgst3 3607
Gclm 3517
Mgst1 2951
Gstp1 2438
Oplah 2169
Ggct 2127
Gstm2 -1249
Cndp2 -1509
Gclc -3673

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gss 4426
Gsto1 4175
Gstm4 3733
Mgst3 3607
Gclm 3517
Mgst1 2951
Gstp1 2438
Oplah 2169
Ggct 2127
Gstm2 -1249
Cndp2 -1509
Gclc -3673


REACTOME_STRIATED_MUSCLE_CONTRACTION

REACTOME_STRIATED_MUSCLE_CONTRACTION
212
set REACTOME_STRIATED_MUSCLE_CONTRACTION
setSize 22
pANOVA 0.00322
s.dist 0.363
p.adjustANOVA 0.038



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mybpc1 4951
Tcap 4843
Dmd 4739
Neb 4138
Actn2 3822
Tpm2 3747
Myl1 3651
Des 3471
Tnni2 3372
Myl2 3277
Tnnc2 3144
Tmod1 2465
Tpm1 2277
Tnnt1 2012
Myl3 1926
Myl4 699
Tnni1 -166
Tnnc1 -494
Mybpc2 -725
Tpm3 -2128

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mybpc1 4951
Tcap 4843
Dmd 4739
Neb 4138
Actn2 3822
Tpm2 3747
Myl1 3651
Des 3471
Tnni2 3372
Myl2 3277
Tnnc2 3144
Tmod1 2465
Tpm1 2277
Tnnt1 2012
Myl3 1926
Myl4 699
Tnni1 -166
Tnnc1 -494
Mybpc2 -725
Tpm3 -2128
Tpm4 -3619
Vim -4606


REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION

REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
220
set REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
setSize 86
pANOVA 7.6e-09
s.dist -0.361
p.adjustANOVA 4.47e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl3 -4706
Rpl12 -4664
Rps3 -4613
Rps6 -4508
Rpl11 -4496
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rpl18a -4328
Rpl5 -4205
Rps9 -4204
Rplp0 -4122
Rpl37a -4109
Rpl30 -4102
Rpl8 -4099
Rps3a1 -4063
Rps8 -4062
Rpl38 -4020
Rps24 -3987
Rps23 -3948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl3 -4706.0
Rpl12 -4664.0
Rps3 -4613.0
Rps6 -4508.0
Rpl11 -4496.0
Rps4x -4476.0
Rps7 -4463.0
Rps18 -4428.0
Rpl18a -4328.0
Rpl5 -4205.0
Rps9 -4204.0
Rplp0 -4122.0
Rpl37a -4109.0
Rpl30 -4102.0
Rpl8 -4099.0
Rps3a1 -4063.0
Rps8 -4062.0
Rpl38 -4020.0
Rps24 -3987.0
Rps23 -3948.0
Rps16 -3928.0
Rpl6 -3907.0
Rps20 -3879.0
Rps13 -3742.0
Rpsa -3686.0
Rps25 -3603.0
Rplp2 -3535.0
Rps26 -3489.0
Rpl14 -3484.0
Rpl28 -3471.0
Eif3k -3419.0
Rps15a -3365.0
Rpl23 -3347.0
Eif3f -3228.0
Rps11 -3099.0
Rpl26 -3053.0
Rpl13 -2756.0
Rps14 -2751.0
Eif3b -2694.0
Eif3h -2634.0
Eif2s3x -2463.0
Rpl4 -2436.0
Rpl15 -2333.0
Rpl18 -2246.0
Rps5 -2186.0
Rpl32 -2111.0
Rpl22 -2109.0
Rpl34 -1902.0
Rpl10a -1894.0
Rpl23a -1819.0
Rps12-ps3 -1676.0
Eif1ax -1642.0
Rpl19 -1606.0
Rpl29 -1550.0
Eif3e -1454.0
Rps19 -1015.0
Rpl37 -885.0
Eif3d -826.0
Eif3g -775.0
Rpl27a -765.0
Rpl41 -569.0
Rps27 -456.0
Rps27a -418.0
Rplp1 -401.0
Rpl36al -390.0
Eif3c -358.0
Rpl35 -260.0
Rps21 -163.0
Eif4a1 445.0
Eif4b 490.0
Rps17 744.0
Eif4a2 816.0
Rpl27-ps3 1035.5
Eif3j2 1754.0
Rpl24 2028.0
Rpl39 2029.0
Eif3i 2584.0
Eif4g1 3133.0
Eif3a 3198.0
Eif2s1 3526.0
Rpl3l 4079.0
Eif4h 4115.0
Eif4e 4242.0
Eif2s2 4274.0
Uba52 4621.0
Rps29 4695.0


REACTOME_RAP1_SIGNALLING

REACTOME_RAP1_SIGNALLING
349
set REACTOME_RAP1_SIGNALLING
setSize 12
pANOVA 0.0329
s.dist -0.356
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rasgrp2 -4656
Ywhab -4620
Sipa1 -4349
Prkacb -4339
Rap1b -3816
Rap1gap -2858
Rapgef3 -2268
Rap1gap2 -1945
Rap1a -842
Prkaca 1048
Raf1 4168
Prkg1 4872

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rasgrp2 -4656
Ywhab -4620
Sipa1 -4349
Prkacb -4339
Rap1b -3816
Rap1gap -2858
Rapgef3 -2268
Rap1gap2 -1945
Rap1a -842
Prkaca 1048
Raf1 4168
Prkg1 4872


REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE

REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE
236
set REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE
setSize 10
pANOVA 0.0536
s.dist -0.353
p.adjustANOVA 0.212



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gnai2 -4502
Gnb4 -3608
Gng12 -2886
Gnb2 -2386
Gnao1 -2302
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gng5 1271
Adcy6 1487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnai2 -4502
Gnb4 -3608
Gng12 -2886
Gnb2 -2386
Gnao1 -2302
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gng5 1271
Adcy6 1487


REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
65
set REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
setSize 42
pANOVA 0.000145
s.dist 0.339
p.adjustANOVA 0.0036



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gfer 4913
Tomm7 4902
Grpel2 4810
Timm17a 4667
Tomm5 4438
Slc25a4 4424
Timm8a1 4114
Atp5b 4068
Aco2 4062
Tomm22 4039
Atp5g1 3957
Vdac1 3771
Samm50 3647
Hspa9 3542
Timm23 3208
Atp5a1 2948
Timm44 2941
Slc25a12 2711
Idh3g 2704
Pmpcb 2649

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gfer 4913
Tomm7 4902
Grpel2 4810
Timm17a 4667
Tomm5 4438
Slc25a4 4424
Timm8a1 4114
Atp5b 4068
Aco2 4062
Tomm22 4039
Atp5g1 3957
Vdac1 3771
Samm50 3647
Hspa9 3542
Timm23 3208
Atp5a1 2948
Timm44 2941
Slc25a12 2711
Idh3g 2704
Pmpcb 2649
Mtx2 2406
Tomm20 2310
Cs 1875
Timm50 1705
Hspd1 1526
Cyc1 1503
Pmpca 1488
Grpel1 1419
Tomm40 1329
Dnajc19 938
Timm22 857
Ldhd 665
Hscb -556
Mtx1 -1025
Timm9 -1338
Timm13 -1824
Coq2 -1840
Timm10 -1879
Bcs1l -1929
Timm17b -2984
Timm8b -3951
Fxn -4333


REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION

REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION
64
set REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION
setSize 18
pANOVA 0.013
s.dist -0.338
p.adjustANOVA 0.0989



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ccnd1 -4126
Notch2 -4096
Notch4 -3819
Tnrc6c -3818
E2f3 -3757
Notch3 -3505
Snw1 -2952
Tnrc6a -2836
Trp53 -2816
Kat2a -2097
Crebbp -1010
Tfdp1 -656
Rbpj -348
Tnrc6b 28
Ep300 608
Maml1 1219
Jun 2880
Kat2b 3240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ccnd1 -4126
Notch2 -4096
Notch4 -3819
Tnrc6c -3818
E2f3 -3757
Notch3 -3505
Snw1 -2952
Tnrc6a -2836
Trp53 -2816
Kat2a -2097
Crebbp -1010
Tfdp1 -656
Rbpj -348
Tnrc6b 28
Ep300 608
Maml1 1219
Jun 2880
Kat2b 3240


REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE

REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE
39
set REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE
setSize 18
pANOVA 0.0162
s.dist 0.327
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc25a20 4676
Cab39 4528
Acsl1 4400
Cpt2 4096
Prkaa2 3920
Strada 2990
Cpt1b 2872
Stradb 2863
Prkab2 2831
Stk11 2453
Acacb 1904
Cab39l 1471
Prkag2 589
Prkaa1 166
Prkag1 -1202
Prkag3 -2078
Cpt1a -2255
Prkab1 -3933

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc25a20 4676
Cab39 4528
Acsl1 4400
Cpt2 4096
Prkaa2 3920
Strada 2990
Cpt1b 2872
Stradb 2863
Prkab2 2831
Stk11 2453
Acacb 1904
Cab39l 1471
Prkag2 589
Prkaa1 166
Prkag1 -1202
Prkag3 -2078
Cpt1a -2255
Prkab1 -3933


REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
274
set REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
setSize 16
pANOVA 0.0237
s.dist 0.327
p.adjustANOVA 0.133



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ivd 4450
Hibch 4356
Dld 4144
Acat1 4085
Hibadh 3936
Dbt 3931
Acad8 1783
Bckdha 1690
Mccc1 1529
Acadsb 1133
Auh 1034
Aldh6a1 727
Hsd17b10 243
Bcat2 -920
Mccc2 -1979
Bckdhb -3260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ivd 4450
Hibch 4356
Dld 4144
Acat1 4085
Hibadh 3936
Dbt 3931
Acad8 1783
Bckdha 1690
Mccc1 1529
Acadsb 1133
Auh 1034
Aldh6a1 727
Hsd17b10 243
Bcat2 -920
Mccc2 -1979
Bckdhb -3260


REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR

REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR
275
set REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR
setSize 11
pANOVA 0.0607
s.dist -0.327
p.adjustANOVA 0.217



Top enriched genes

Top 20 genes
GeneID Gene Rank
Notch2 -4096
Notch4 -3819
Notch3 -3505
Jag2 -2923
Adam17 -2006
Dll1 -1806
Dll4 -1636
Jag1 -838
Rps27a -418
Adam10 3
Uba52 4621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch2 -4096
Notch4 -3819
Notch3 -3505
Jag2 -2923
Adam17 -2006
Dll1 -1806
Dll4 -1636
Jag1 -838
Rps27a -418
Adam10 3
Uba52 4621


REACTOME_SIGNAL_AMPLIFICATION

REACTOME_SIGNAL_AMPLIFICATION
279
set REACTOME_SIGNAL_AMPLIFICATION
setSize 14
pANOVA 0.0348
s.dist -0.326
p.adjustANOVA 0.16



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gnai2 -4502
Gnb4 -3608
P2ry1 -3522
Gnai3 -3113
Gng12 -2886
Gnb2 -2386
Mapk14 -1738
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gnaq -743
Gna11 1043
Gng5 1271
Gna13 2604

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnai2 -4502
Gnb4 -3608
P2ry1 -3522
Gnai3 -3113
Gng12 -2886
Gnb2 -2386
Mapk14 -1738
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gnaq -743
Gna11 1043
Gng5 1271
Gna13 2604


REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT

REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT
397
set REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT
setSize 23
pANOVA 0.00738
s.dist -0.323
p.adjustANOVA 0.0682



Top enriched genes

Top 20 genes
GeneID Gene Rank
Plin1 -4745
Apoe -4727
Lipe -4576
Fabp4 -4446
Abcg1 -4398
Prkacb -4339
Pltp -4185
Abca1 -4076
Ppp1ca -1608
Ldlr -1552
Ppp1cb -1546
Mgll -1336
Cav1 -577
Ppp1cc -574
Bmp1 -450
P4hb -277
Scarb1 -97
Ldlrap1 137
Prkaca 1048
Lpl 1307

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plin1 -4745
Apoe -4727
Lipe -4576
Fabp4 -4446
Abcg1 -4398
Prkacb -4339
Pltp -4185
Abca1 -4076
Ppp1ca -1608
Ldlr -1552
Ppp1cb -1546
Mgll -1336
Cav1 -577
Ppp1cc -574
Bmp1 -450
P4hb -277
Scarb1 -97
Ldlrap1 137
Prkaca 1048
Lpl 1307
Sar1b 1600
Abhd5 2418
Hspg2 3127


REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
440
set REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
setSize 11
pANOVA 0.0645
s.dist 0.322
p.adjustANOVA 0.228



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kcna7 4850
Kcnc1 4553
Kcnf1 3687
Kcnq4 2541
Kcnc4 2479
Kcng4 1845
Kcnq5 1768
Kcnab1 -275
Kcnc3 -350
Kcnb1 -588
Kcna5 -2276

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kcna7 4850
Kcnc1 4553
Kcnf1 3687
Kcnq4 2541
Kcnc4 2479
Kcng4 1845
Kcnq5 1768
Kcnab1 -275
Kcnc3 -350
Kcnb1 -588
Kcna5 -2276


REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING

REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
194
set REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
setSize 18
pANOVA 0.0195
s.dist -0.318
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
Csk -4760
Rasgrp2 -4656
Syk -4621
Grb2 -3931
Ptpn1 -3863
Rap1b -3816
Akt1 -3454
Vwf -2876
Shc1 -2680
Rapgef3 -2268
Pdpk1 -1811
Tln1 -1666
Rap1a -842
Sos1 925
Crk 2911
Fn1 3403
Ptk2 3561
Bcar1 4327

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Csk -4760
Rasgrp2 -4656
Syk -4621
Grb2 -3931
Ptpn1 -3863
Rap1b -3816
Akt1 -3454
Vwf -2876
Shc1 -2680
Rapgef3 -2268
Pdpk1 -1811
Tln1 -1666
Rap1a -842
Sos1 925
Crk 2911
Fn1 3403
Ptk2 3561
Bcar1 4327


REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX

REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX
301
set REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX
setSize 16
pANOVA 0.0278
s.dist -0.318
p.adjustANOVA 0.142



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ikbkb -4135
Traf6 -3511
Nod1 -3234
Rela -3065
App -2632
Irak1 -2491
Nfkbia -2126
Tab3 -1976
Tab2 -1758
Chuk -1574
Nfkb2 -890
Nfkbib -460
Irak2 -73
Ikbkg 1303
Map3k7 1688
Tab1 1741

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ikbkb -4135
Traf6 -3511
Nod1 -3234
Rela -3065
App -2632
Irak1 -2491
Nfkbia -2126
Tab3 -1976
Tab2 -1758
Chuk -1574
Nfkb2 -890
Nfkbib -460
Irak2 -73
Ikbkg 1303
Map3k7 1688
Tab1 1741


REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA

REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
258
set REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
setSize 11
pANOVA 0.069
s.dist -0.317
p.adjustANOVA 0.23



Top enriched genes

Top 20 genes
GeneID Gene Rank
Akt3 -3909
Gnb4 -3608
Akt1 -3454
Gng12 -2886
Gnb2 -2386
Pdpk1 -1811
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gng5 1271
Akt2 4151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Akt3 -3909
Gnb4 -3608
Akt1 -3454
Gng12 -2886
Gnb2 -2386
Pdpk1 -1811
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gng5 1271
Akt2 4151


REACTOME_ADP_SIGNALLING_THROUGH_P2RY1

REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
248
set REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
setSize 11
pANOVA 0.07
s.dist -0.316
p.adjustANOVA 0.231



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gnb4 -3608
P2ry1 -3522
Gng12 -2886
Gnb2 -2386
Mapk14 -1738
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gnaq -743
Gna11 1043
Gng5 1271

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnb4 -3608
P2ry1 -3522
Gng12 -2886
Gnb2 -2386
Mapk14 -1738
Gng11 -1347
Gnb5 -1125
Gnb1 -788
Gnaq -743
Gna11 1043
Gng5 1271


REACTOME_DOWNSTREAM_TCR_SIGNALING

REACTOME_DOWNSTREAM_TCR_SIGNALING
138
set REACTOME_DOWNSTREAM_TCR_SIGNALING
setSize 20
pANOVA 0.0161
s.dist -0.311
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2-Eb1 -4708
H2-Aa -4684
Ikbkb -4135
Pik3r1 -4097
Traf6 -3511
Bcl10 -3087
Rela -3065
Malt1 -2401
Nfkbia -2126
Pten -1997
Pdpk1 -1811
Tab2 -1758
Chuk -1574
Pik3ca -534
Prkcq 788
Gm20431 976
Ikbkg 1303
Map3k7 1688
Pik3r2 2281
Pik3cb 4153

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2-Eb1 -4708
H2-Aa -4684
Ikbkb -4135
Pik3r1 -4097
Traf6 -3511
Bcl10 -3087
Rela -3065
Malt1 -2401
Nfkbia -2126
Pten -1997
Pdpk1 -1811
Tab2 -1758
Chuk -1574
Pik3ca -534
Prkcq 788
Gm20431 976
Ikbkg 1303
Map3k7 1688
Pik3r2 2281
Pik3cb 4153


REACTOME_INFLUENZA_LIFE_CYCLE

REACTOME_INFLUENZA_LIFE_CYCLE
399
set REACTOME_INFLUENZA_LIFE_CYCLE
setSize 115
pANOVA 1.77e-08
s.dist -0.305
p.adjustANOVA 9.27e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl3 -4706
Rpl12 -4664
Rps3 -4613
Rps6 -4508
Rpl11 -4496
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rpl18a -4328
Rpl5 -4205
Rps9 -4204
Rplp0 -4122
Calr -4121
Rpl37a -4109
Rpl30 -4102
Rpl8 -4099
Rps3a1 -4063
Rps8 -4062
Polr2a -4055
Rpl38 -4020

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl3 -4706.0
Rpl12 -4664.0
Rps3 -4613.0
Rps6 -4508.0
Rpl11 -4496.0
Rps4x -4476.0
Rps7 -4463.0
Rps18 -4428.0
Rpl18a -4328.0
Rpl5 -4205.0
Rps9 -4204.0
Rplp0 -4122.0
Calr -4121.0
Rpl37a -4109.0
Rpl30 -4102.0
Rpl8 -4099.0
Rps3a1 -4063.0
Rps8 -4062.0
Polr2a -4055.0
Rpl38 -4020.0
Rps24 -3987.0
Rps23 -3948.0
Rps16 -3928.0
Rpl6 -3907.0
Rps20 -3879.0
Rps13 -3742.0
Rpsa -3686.0
Canx -3644.0
Rps25 -3603.0
Rplp2 -3535.0
Rps26 -3489.0
Rpl14 -3484.0
Rpl28 -3471.0
Rps15a -3365.0
Rpl23 -3347.0
Polr2h -3277.0
Polr2g -3267.0
Rae1 -3229.0
Rps11 -3099.0
Rpl26 -3053.0
Polr2f -2963.0
Nup133 -2945.0
Polr2b -2820.0
Rpl13 -2756.0
Polr2e -2755.0
Rps14 -2751.0
Nup54 -2727.0
Nup107 -2573.0
Polr2j -2499.0
Rpl4 -2436.0
Rpl15 -2333.0
Rpl18 -2246.0
Nup155 -2200.0
Gtf2f2 -2196.0
Rps5 -2186.0
Rpl32 -2111.0
Rpl22 -2109.0
Nup43 -2023.0
Rpl34 -1902.0
Rpl10a -1894.0
Rpl23a -1819.0
Nup85 -1789.0
Kpnb1 -1728.0
Rps12-ps3 -1676.0
Nup205 -1623.0
Rpl19 -1606.0
Rpl29 -1550.0
Ran -1425.0
Clta -1110.0
Nup88 -1059.0
Rps19 -1015.0
Rpl37 -885.0
Polr2c -851.0
Nup93 -820.0
Rpl27a -765.0
Rpl41 -569.0
Xpo1 -527.0
Nup153 -478.0
Rps27 -456.0
Rps27a -418.0
Rplp1 -401.0
Rpl36al -390.0
Cltc -338.0
Nup188 -266.0
Rpl35 -260.0
Rps21 -163.0
Nup210 79.0
Gtf2f1 447.0
Rps17 744.0
Dnajc3 849.0
Nup214 888.0
Rpl27-ps3 1035.5
Nup35 1111.0
Polr2l 1527.0
Kpna1 1599.0
Ipo5 1817.0
Aaas 1971.0
Rpl24 2028.0
Rpl39 2029.0
Polr2d 2488.0
Tpr 2631.0
Hsp90aa1 2636.0
Nup37 2694.0
Nup62 2855.0
Ranbp2 2970.0
Polr2i 2986.0
Polr2k 3181.0
Nupl2 3363.0
Pom121 3705.0
Rpl3l 4079.0
Hspa1b 4112.0
Grsf1 4158.0
Seh1l 4206.0
Uba52 4621.0
Rps29 4695.0


REACTOME_BASE_EXCISION_REPAIR

REACTOME_BASE_EXCISION_REPAIR
11
set REACTOME_BASE_EXCISION_REPAIR
setSize 13
pANOVA 0.0592
s.dist -0.302
p.adjustANOVA 0.216



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pold1 -4571
Apex1 -4088
Tdg -3889
Pold3 -3783
Mpg -2887
Pold4 -2476
Pcna -2466
Xrcc1 -2073
Lig3 -1124
Ogg1 104
Smug1 1814
Pold2 2930
Polb 4642

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pold1 -4571
Apex1 -4088
Tdg -3889
Pold3 -3783
Mpg -2887
Pold4 -2476
Pcna -2466
Xrcc1 -2073
Lig3 -1124
Ogg1 104
Smug1 1814
Pold2 2930
Polb 4642


REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S

REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S
143
set REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S
setSize 49
pANOVA 0.000256
s.dist -0.302
p.adjustANOVA 0.00503



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps3 -4613
Rps6 -4508
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rps9 -4204
Rps3a1 -4063
Rps8 -4062
Rps24 -3987
Rps23 -3948
Rps16 -3928
Rps20 -3879
Rps13 -3742
Rpsa -3686
Rps25 -3603
Rps26 -3489
Eif3k -3419
Rps15a -3365
Eif3f -3228
Rps11 -3099

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps3 -4613
Rps6 -4508
Rps4x -4476
Rps7 -4463
Rps18 -4428
Rps9 -4204
Rps3a1 -4063
Rps8 -4062
Rps24 -3987
Rps23 -3948
Rps16 -3928
Rps20 -3879
Rps13 -3742
Rpsa -3686
Rps25 -3603
Rps26 -3489
Eif3k -3419
Rps15a -3365
Eif3f -3228
Rps11 -3099
Rps14 -2751
Eif3b -2694
Eif3h -2634
Eif2s3x -2463
Rps5 -2186
Rps12-ps3 -1676
Eif1ax -1642
Eif3e -1454
Eif4ebp1 -1375
Rps19 -1015
Eif3d -826
Eif3g -775
Rps27 -456
Rps27a -418
Eif3c -358
Rps21 -163
Eif4a1 445
Eif4b 490
Rps17 744
Eif4a2 816
Eif3j2 1754
Eif3i 2584
Eif4g1 3133
Eif3a 3198
Eif2s1 3526
Eif4h 4115
Eif4e 4242
Eif2s2 4274
Rps29 4695


REACTOME_REGULATION_OF_KIT_SIGNALING

REACTOME_REGULATION_OF_KIT_SIGNALING
35
set REACTOME_REGULATION_OF_KIT_SIGNALING
setSize 12
pANOVA 0.0716
s.dist -0.301
p.adjustANOVA 0.234



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn6 -4695
Cbl -4268
Lyn -4120
Grb2 -3931
Kitl -3549
Sh2b3 -2917
Fyn -974
Socs1 -307
Sos1 925
Prkca 1012
Socs6 2565
Yes1 3869

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn6 -4695
Cbl -4268
Lyn -4120
Grb2 -3931
Kitl -3549
Sh2b3 -2917
Fyn -974
Socs1 -307
Sos1 925
Prkca 1012
Socs6 2565
Yes1 3869


REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1

REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1
229
set REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1
setSize 20
pANOVA 0.0219
s.dist -0.296
p.adjustANOVA 0.13



Top enriched genes

Top 20 genes
GeneID Gene Rank
Itpr3 -4597
Prkacb -4339
Iqgap1 -4181
Rap1b -3816
Gnb4 -3608
Gng12 -2886
Gnb2 -2386
Rapgef3 -2268
Prkar1a -2191
Gng11 -1347
Itpr2 -1147
Gnb5 -1125
Rap1a -842
Gnb1 -788
Kcnb1 -588
Prkaca 1048
Gng5 1271
Adcy6 1487
Gnas 2278
Prkar2a 3157

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itpr3 -4597
Prkacb -4339
Iqgap1 -4181
Rap1b -3816
Gnb4 -3608
Gng12 -2886
Gnb2 -2386
Rapgef3 -2268
Prkar1a -2191
Gng11 -1347
Itpr2 -1147
Gnb5 -1125
Rap1a -842
Gnb1 -788
Kcnb1 -588
Prkaca 1048
Gng5 1271
Adcy6 1487
Gnas 2278
Prkar2a 3157


REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY

REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY
45
set REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY
setSize 11
pANOVA 0.0916
s.dist -0.294
p.adjustANOVA 0.268



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pold1 -4571
Apex1 -4088
Tdg -3889
Pold3 -3783
Mpg -2887
Pold4 -2476
Pcna -2466
Ogg1 104
Smug1 1814
Pold2 2930
Polb 4642

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pold1 -4571
Apex1 -4088
Tdg -3889
Pold3 -3783
Mpg -2887
Pold4 -2476
Pcna -2466
Ogg1 104
Smug1 1814
Pold2 2930
Polb 4642


REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION

REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
355
set REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
setSize 13
pANOVA 0.0673
s.dist -0.293
p.adjustANOVA 0.23



Top enriched genes

Top 20 genes
GeneID Gene Rank
Map3k1 -4218
Ikbkb -4135
Traf6 -3511
Rela -3065
App -2632
Nfkbia -2126
Chuk -1574
Trim25 -1007
Nfkb2 -890
Nfkbib -460
Traf2 1087
Ikbkg 1303
Mavs 3937

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Map3k1 -4218
Ikbkb -4135
Traf6 -3511
Rela -3065
App -2632
Nfkbia -2126
Chuk -1574
Trim25 -1007
Nfkb2 -890
Nfkbib -460
Traf2 1087
Ikbkg 1303
Mavs 3937


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report