Mitch Report

date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     stat
## 0610009B22Rik  1.1168615
## 0610009L18Rik  0.2160756
## 0610010K14Rik  0.6692320
## 0610012G03Rik  0.4088542
## 0610030E20Rik  0.2111877
## 0610040J01Rik -1.4975473

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	674
num_genes_in_profile	9471
duplicated_genes_present	0
num_profile_genes_in_sets	2794
num_profile_genes_not_in_sets	6677

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	674
num_genesets_excluded	211
num_genesets_included	463

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	5.14e-05	-0.649	0.00863
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	2.15e-03	0.535	0.03200
REACTOME TRAFFICKING OF AMPA RECEPTORS	16	6.00e-04	0.496	0.01850
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	1.26e-04	0.495	0.01020
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	4.20e-03	-0.380	0.04740
REACTOME NCAM1 INTERACTIONS	18	5.61e-03	0.377	0.05600
REACTOME INTERFERON GAMMA SIGNALING	24	1.39e-03	0.377	0.02800
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	17	1.30e-02	0.348	0.09490
REACTOME COMPLEMENT CASCADE	11	4.59e-02	0.348	0.21900
REACTOME TRNA AMINOACYLATION	39	1.90e-04	0.346	0.01100
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	11	5.23e-02	-0.338	0.22700
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	12	4.28e-02	-0.338	0.21100
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	16	1.98e-02	0.337	0.12600
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	5.46e-02	-0.335	0.22800
REACTOME ADP SIGNALLING THROUGH P2RY1	12	4.81e-02	-0.330	0.22700
REACTOME MEIOTIC RECOMBINATION	11	6.16e-02	0.326	0.24700
REACTOME SMOOTH MUSCLE CONTRACTION	19	1.62e-02	-0.319	0.11200
REACTOME G PROTEIN BETA GAMMA SIGNALLING	13	4.92e-02	-0.315	0.22700
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	9.47e-04	-0.310	0.02470
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	3.73e-02	-0.301	0.19200
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	19	2.34e-02	0.301	0.14100
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	15	4.46e-02	0.300	0.21700
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	13	6.28e-02	0.298	0.24700
REACTOME SIGNALING BY NODAL	11	9.10e-02	-0.294	0.29700
REACTOME SYNTHESIS OF PA	12	8.81e-02	-0.284	0.29400
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	41	1.67e-03	0.284	0.03080
REACTOME METABOLISM OF POLYAMINES	12	9.03e-02	0.282	0.29700
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	24	1.68e-02	0.282	0.11500
REACTOME ION CHANNEL TRANSPORT	18	3.87e-02	-0.282	0.19500
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	47	9.21e-04	0.280	0.02470
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	15	6.25e-02	0.278	0.24700
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	44	1.51e-03	-0.277	0.02920
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	22	2.53e-02	-0.276	0.14600
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	23	2.27e-02	0.275	0.13800
REACTOME PLATELET HOMEOSTASIS	33	7.13e-03	-0.271	0.06600
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	9.24e-02	0.270	0.29700
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	44	2.02e-03	0.269	0.03180
REACTOME CELL CYCLE CHECKPOINTS	80	3.43e-05	0.268	0.00863
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	11	1.25e-01	0.267	0.35800
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	42	2.96e-03	0.265	0.04150
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	38	4.73e-03	0.265	0.04980
REACTOME METAL ION SLC TRANSPORTERS	12	1.13e-01	-0.265	0.34500
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	16	6.91e-02	-0.263	0.25800
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	53	1.02e-03	0.261	0.02490
REACTOME PEPTIDE CHAIN ELONGATION	66	2.50e-04	0.261	0.01100
REACTOME ORC1 REMOVAL FROM CHROMATIN	51	1.33e-03	0.260	0.02790
REACTOME PHOSPHORYLATION OF THE APC C	14	9.23e-02	0.260	0.29700
REACTOME G2 M CHECKPOINTS	19	5.24e-02	0.257	0.22700
REACTOME REGULATION OF MITOTIC CELL CYCLE	61	5.30e-04	0.257	0.01810
REACTOME ION TRANSPORT BY P TYPE ATPASES	17	6.78e-02	-0.256	0.25600

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	5.14e-05	-0.649000	0.00863
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	2.15e-03	0.535000	0.03200
REACTOME TRAFFICKING OF AMPA RECEPTORS	16	6.00e-04	0.496000	0.01850
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	1.26e-04	0.495000	0.01020
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	4.20e-03	-0.380000	0.04740
REACTOME NCAM1 INTERACTIONS	18	5.61e-03	0.377000	0.05600
REACTOME INTERFERON GAMMA SIGNALING	24	1.39e-03	0.377000	0.02800
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	17	1.30e-02	0.348000	0.09490
REACTOME COMPLEMENT CASCADE	11	4.59e-02	0.348000	0.21900
REACTOME TRNA AMINOACYLATION	39	1.90e-04	0.346000	0.01100
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	11	5.23e-02	-0.338000	0.22700
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	12	4.28e-02	-0.338000	0.21100
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	16	1.98e-02	0.337000	0.12600
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	5.46e-02	-0.335000	0.22800
REACTOME ADP SIGNALLING THROUGH P2RY1	12	4.81e-02	-0.330000	0.22700
REACTOME MEIOTIC RECOMBINATION	11	6.16e-02	0.326000	0.24700
REACTOME SMOOTH MUSCLE CONTRACTION	19	1.62e-02	-0.319000	0.11200
REACTOME G PROTEIN BETA GAMMA SIGNALLING	13	4.92e-02	-0.315000	0.22700
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	9.47e-04	-0.310000	0.02470
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	3.73e-02	-0.301000	0.19200
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	19	2.34e-02	0.301000	0.14100
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	15	4.46e-02	0.300000	0.21700
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	13	6.28e-02	0.298000	0.24700
REACTOME SIGNALING BY NODAL	11	9.10e-02	-0.294000	0.29700
REACTOME SYNTHESIS OF PA	12	8.81e-02	-0.284000	0.29400
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	41	1.67e-03	0.284000	0.03080
REACTOME METABOLISM OF POLYAMINES	12	9.03e-02	0.282000	0.29700
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	24	1.68e-02	0.282000	0.11500
REACTOME ION CHANNEL TRANSPORT	18	3.87e-02	-0.282000	0.19500
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	47	9.21e-04	0.280000	0.02470
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	15	6.25e-02	0.278000	0.24700
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	44	1.51e-03	-0.277000	0.02920
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	22	2.53e-02	-0.276000	0.14600
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	23	2.27e-02	0.275000	0.13800
REACTOME PLATELET HOMEOSTASIS	33	7.13e-03	-0.271000	0.06600
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	9.24e-02	0.270000	0.29700
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	44	2.02e-03	0.269000	0.03180
REACTOME CELL CYCLE CHECKPOINTS	80	3.43e-05	0.268000	0.00863
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	11	1.25e-01	0.267000	0.35800
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	42	2.96e-03	0.265000	0.04150
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	38	4.73e-03	0.265000	0.04980
REACTOME METAL ION SLC TRANSPORTERS	12	1.13e-01	-0.265000	0.34500
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	16	6.91e-02	-0.263000	0.25800
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	53	1.02e-03	0.261000	0.02490
REACTOME PEPTIDE CHAIN ELONGATION	66	2.50e-04	0.261000	0.01100
REACTOME ORC1 REMOVAL FROM CHROMATIN	51	1.33e-03	0.260000	0.02790
REACTOME PHOSPHORYLATION OF THE APC C	14	9.23e-02	0.260000	0.29700
REACTOME G2 M CHECKPOINTS	19	5.24e-02	0.257000	0.22700
REACTOME REGULATION OF MITOTIC CELL CYCLE	61	5.30e-04	0.257000	0.01810
REACTOME ION TRANSPORT BY P TYPE ATPASES	17	6.78e-02	-0.256000	0.25600
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	16	7.68e-02	-0.256000	0.27100
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	56	9.58e-04	0.256000	0.02470
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	3.84e-02	0.255000	0.19500
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	16	7.76e-02	-0.255000	0.27200
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	42	4.33e-03	0.255000	0.04770
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	18	6.24e-02	0.254000	0.24700
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	13	1.14e-01	0.253000	0.34600
REACTOME SYNTHESIS OF DNA	63	5.47e-04	0.252000	0.01810
REACTOME GLUCOSE TRANSPORT	29	1.91e-02	0.252000	0.12300
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	45	3.71e-03	0.250000	0.04300
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	42	5.09e-03	0.250000	0.05240
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	11	1.53e-01	0.249000	0.41900
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	88	5.59e-05	0.249000	0.00863
REACTOME PEROXISOMAL LIPID METABOLISM	16	8.68e-02	-0.247000	0.29400
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	24	3.61e-02	0.247000	0.18800
REACTOME PYRUVATE METABOLISM	16	8.84e-02	-0.246000	0.29400
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	13	1.25e-01	-0.246000	0.35800
REACTOME MUSCLE CONTRACTION	38	8.88e-03	-0.246000	0.07480
REACTOME GLYCOLYSIS	19	6.51e-02	0.245000	0.25100
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	43	5.84e-03	0.243000	0.05640
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	56	1.78e-03	0.242000	0.03170
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	16	9.50e-02	-0.241000	0.30300
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	42	7.02e-03	0.241000	0.06600
REACTOME PLATELET SENSITIZATION BY LDL	11	1.67e-01	-0.241000	0.45000
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	19	7.21e-02	0.238000	0.26400
REACTOME REGULATION OF APOPTOSIS	48	4.69e-03	0.236000	0.04980
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	10	1.98e-01	0.235000	0.50400
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	40	1.04e-02	0.234000	0.08330
REACTOME DOUBLE STRAND BREAK REPAIR	12	1.60e-01	0.234000	0.43400
REACTOME PLATELET AGGREGATION PLUG FORMATION	18	8.71e-02	-0.233000	0.29400
REACTOME EGFR DOWNREGULATION	23	5.37e-02	0.233000	0.22800
REACTOME M G1 TRANSITION	53	3.59e-03	0.232000	0.04300
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	10	2.07e-01	-0.231000	0.50800
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	14	1.37e-01	-0.230000	0.38700
REACTOME BIOLOGICAL OXIDATIONS	40	1.31e-02	-0.227000	0.09490
REACTOME GLOBAL GENOMIC NER GG NER	26	4.57e-02	0.227000	0.21900
REACTOME GPCR LIGAND BINDING	42	1.18e-02	-0.225000	0.09130
REACTOME SIGNAL AMPLIFICATION	15	1.32e-01	-0.225000	0.37500
REACTOME HOST INTERACTIONS OF HIV FACTORS	98	1.32e-04	0.224000	0.01020
REACTOME ENOS ACTIVATION AND REGULATION	12	1.80e-01	-0.224000	0.47100
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	49	7.47e-03	0.221000	0.06650
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	10	2.26e-01	0.221000	0.53200
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	43	1.27e-02	0.220000	0.09490
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	23	6.97e-02	0.219000	0.25800
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	11	2.13e-01	-0.217000	0.51500
REACTOME PHASE II CONJUGATION	24	6.64e-02	-0.217000	0.25400
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	17	1.25e-01	-0.215000	0.35800
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	21	9.00e-02	0.214000	0.29700
REACTOME G ALPHA Q SIGNALLING EVENTS	42	1.74e-02	-0.212000	0.11700
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	16	1.46e-01	-0.210000	0.40600
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	27	5.89e-02	-0.210000	0.23900
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	28	5.47e-02	0.210000	0.22800
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	18	1.24e-01	-0.210000	0.35800
REACTOME STRIATED MUSCLE CONTRACTION	23	8.29e-02	-0.209000	0.28600
REACTOME G PROTEIN ACTIVATION	11	2.31e-01	-0.209000	0.53900
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	11	2.35e-01	0.207000	0.54500
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	29	5.50e-02	0.206000	0.22800
REACTOME AQUAPORIN MEDIATED TRANSPORT	23	8.79e-02	-0.206000	0.29400
REACTOME ER PHAGOSOME PATHWAY	48	1.41e-02	0.205000	0.09950
REACTOME DNA STRAND ELONGATION	15	1.76e-01	0.202000	0.46900
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	51	1.29e-02	0.202000	0.09490
REACTOME INFLUENZA LIFE CYCLE	113	2.28e-04	0.201000	0.01100
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	10	2.75e-01	-0.200000	0.58300
REACTOME TIE2 SIGNALING	13	2.16e-01	-0.198000	0.51700
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	41	2.83e-02	0.198000	0.16000
REACTOME S PHASE	73	3.51e-03	0.198000	0.04300
REACTOME GLUCOSE METABOLISM	43	2.52e-02	0.198000	0.14600
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	33	4.99e-02	0.197000	0.22700
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	22	1.10e-01	-0.197000	0.34100
REACTOME INTERFERON SIGNALING	80	2.36e-03	0.197000	0.03420
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	84	2.03e-03	0.195000	0.03180
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	15	1.91e-01	-0.195000	0.48900
REACTOME METABOLISM OF NON CODING RNA	41	3.10e-02	0.195000	0.16700
REACTOME PI 3K CASCADE	34	5.11e-02	-0.194000	0.22700
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	22	1.19e-01	-0.192000	0.35600
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	11	2.71e-01	-0.192000	0.58300
REACTOME MHC CLASS II ANTIGEN PRESENTATION	61	9.83e-03	0.191000	0.07980
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	10	2.95e-01	0.191000	0.60500
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	45	2.88e-02	0.189000	0.16100
REACTOME GLUTATHIONE CONJUGATION	12	2.60e-01	-0.188000	0.57400
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	82	3.51e-03	0.187000	0.04300
REACTOME G1 S TRANSITION	69	7.39e-03	0.187000	0.06650
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	20	1.51e-01	-0.185000	0.41900
REACTOME RNA POL III CHAIN ELONGATION	16	2.00e-01	0.185000	0.50500
REACTOME MITOTIC G2 G2 M PHASES	50	2.44e-02	0.184000	0.14500
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	85	3.41e-03	0.184000	0.04300
REACTOME LAGGING STRAND SYNTHESIS	10	3.14e-01	0.184000	0.61800
REACTOME TRANSLATION	123	4.80e-04	0.183000	0.01810
REACTOME G ALPHA S SIGNALLING EVENTS	28	1.05e-01	-0.177000	0.32800
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	56	2.21e-02	0.177000	0.13600
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	11	3.10e-01	-0.177000	0.61800
REACTOME RNA POL I TRANSCRIPTION TERMINATION	19	1.84e-01	0.176000	0.47700
REACTOME RNA POL I TRANSCRIPTION INITIATION	23	1.44e-01	0.176000	0.40500
REACTOME COLLAGEN FORMATION	28	1.11e-01	0.174000	0.34200
REACTOME SOS MEDIATED SIGNALLING	13	2.77e-01	0.174000	0.58300
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	5.16e-02	-0.174000	0.22700
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	53	2.91e-02	0.174000	0.16100
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	37	6.81e-02	-0.173000	0.25600
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	51	3.31e-02	0.173000	0.17600
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	10	3.49e-01	-0.171000	0.65800
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	48	4.25e-02	0.169000	0.21100
REACTOME DNA REPLICATION	113	2.05e-03	0.168000	0.03180
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	126	1.17e-03	-0.168000	0.02580
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	19	2.06e-01	-0.168000	0.50800
REACTOME CELL CYCLE MITOTIC	195	9.42e-05	0.163000	0.01020
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	48	5.12e-02	0.163000	0.22700
REACTOME SIGNALING BY BMP	17	2.45e-01	-0.163000	0.54900
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	13	3.16e-01	-0.161000	0.61800
REACTOME GAB1 SIGNALOSOME	32	1.17e-01	-0.160000	0.35300
REACTOME BASE EXCISION REPAIR	12	3.38e-01	0.160000	0.64900
REACTOME MITOTIC M M G1 PHASES	101	5.69e-03	0.160000	0.05600
REACTOME LIPOPROTEIN METABOLISM	11	3.62e-01	0.159000	0.67500
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	19	2.37e-01	-0.157000	0.54600
REACTOME CALNEXIN CALRETICULIN CYCLE	11	3.69e-01	0.157000	0.67700
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	37	1.00e-01	0.156000	0.31800
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	18	2.52e-01	-0.156000	0.56000
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	25	1.78e-01	0.156000	0.47100
REACTOME GLYCOSPHINGOLIPID METABOLISM	19	2.40e-01	-0.156000	0.54600
REACTOME CTNNB1 PHOSPHORYLATION CASCADE	14	3.14e-01	-0.155000	0.61800
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	13	3.32e-01	0.155000	0.64100
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	17	2.73e-01	0.154000	0.58300
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	14	3.24e-01	0.152000	0.63100
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	18	2.64e-01	-0.152000	0.57600
REACTOME EXTENSION OF TELOMERES	15	3.14e-01	0.150000	0.61800
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	13	3.49e-01	0.150000	0.65800
REACTOME SIGNALING BY WNT	56	5.45e-02	0.149000	0.22800
REACTOME MITOTIC G1 G1 S PHASES	85	1.83e-02	0.148000	0.11900
REACTOME GPCR DOWNSTREAM SIGNALING	106	8.58e-03	-0.148000	0.07360
REACTOME P38MAPK EVENTS	10	4.17e-01	-0.148000	0.72200
REACTOME CTLA4 INHIBITORY SIGNALING	16	3.06e-01	-0.148000	0.61800
REACTOME DESTABILIZATION OF MRNA BY BRF1	15	3.26e-01	-0.147000	0.63100
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	25	2.05e-01	-0.147000	0.50800
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	14	3.43e-01	-0.146000	0.65700
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	11	4.02e-01	-0.146000	0.70400
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	16	3.16e-01	0.145000	0.61800
REACTOME GLUCONEOGENESIS	18	2.88e-01	0.145000	0.59900
REACTOME PHOSPHOLIPID METABOLISM	115	7.88e-03	-0.144000	0.06880
REACTOME CELL CYCLE	222	2.53e-04	0.143000	0.01100
REACTOME HIV INFECTION	158	2.06e-03	0.143000	0.03180
REACTOME PROTEIN FOLDING	40	1.21e-01	0.142000	0.35600
REACTOME PIP3 ACTIVATES AKT SIGNALING	25	2.21e-01	-0.141000	0.52300
REACTOME RNA POL III TRANSCRIPTION	31	1.75e-01	0.141000	0.46900
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	28	2.02e-01	-0.139000	0.50700
REACTOME ADP SIGNALLING THROUGH P2RY12	10	4.48e-01	-0.139000	0.73500
REACTOME TELOMERE MAINTENANCE	20	2.84e-01	0.139000	0.59500
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	24	2.41e-01	-0.138000	0.54600
REACTOME MTORC1 MEDIATED SIGNALLING	11	4.31e-01	0.137000	0.72300
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	13	3.97e-01	0.136000	0.70200
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	59	7.24e-02	-0.135000	0.26400
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	11	4.37e-01	0.135000	0.72300
REACTOME RNA POL I TRANSCRIPTION	26	2.41e-01	0.133000	0.54600
REACTOME CD28 CO STIMULATION	23	2.73e-01	-0.132000	0.58300
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	21	2.95e-01	-0.132000	0.60500
REACTOME SIGNALING BY HIPPO	15	3.79e-01	0.131000	0.68600
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	21	2.98e-01	0.131000	0.60900
REACTOME UNFOLDED PROTEIN RESPONSE	62	7.56e-02	-0.131000	0.26900
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	20	3.14e-01	-0.130000	0.61800
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	32	2.03e-01	-0.130000	0.50700
REACTOME METABOLISM OF RNA	215	1.10e-03	0.130000	0.02560
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	24	2.75e-01	-0.129000	0.58300
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	17	3.58e-01	-0.129000	0.67200
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	279	2.62e-04	-0.128000	0.01100
REACTOME DEADENYLATION OF MRNA	16	3.81e-01	-0.126000	0.68700
REACTOME HIV LIFE CYCLE	95	3.42e-02	0.126000	0.18000
REACTOME DNA REPAIR	67	7.50e-02	0.126000	0.26900
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	17	3.69e-01	-0.126000	0.67700
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	2.57e-02	-0.125000	0.14700
REACTOME G1 PHASE	25	2.88e-01	0.123000	0.59900
REACTOME LATE PHASE OF HIV LIFE CYCLE	87	4.84e-02	0.123000	0.22700
REACTOME TCR SIGNALING	28	2.64e-01	-0.122000	0.57600
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	146	1.17e-02	0.121000	0.09130
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	56	1.20e-01	0.120000	0.35600
REACTOME ERKS ARE INACTIVATED	10	5.11e-01	-0.120000	0.78300
REACTOME PPARA ACTIVATES GENE EXPRESSION	80	6.41e-02	-0.120000	0.24900
REACTOME GLYCOSAMINOGLYCAN METABOLISM	48	1.53e-01	-0.119000	0.41900
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	63	1.02e-01	0.119000	0.32200
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	164	9.55e-03	0.118000	0.07900
REACTOME INTERFERON ALPHA BETA SIGNALING	17	4.01e-01	0.118000	0.70400
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	44	1.80e-01	0.117000	0.47100
REACTOME G ALPHA1213 SIGNALLING EVENTS	43	1.87e-01	-0.116000	0.48200
REACTOME DOWNSTREAM TCR SIGNALING	20	3.71e-01	-0.116000	0.67700
REACTOME POTASSIUM CHANNELS	22	3.49e-01	-0.115000	0.65800
REACTOME SHC MEDIATED CASCADE	10	5.28e-01	-0.115000	0.78800
REACTOME ARMS MEDIATED ACTIVATION	14	4.61e-01	0.114000	0.74700
REACTOME KERATAN SULFATE KERATIN METABOLISM	14	4.61e-01	-0.114000	0.74700
REACTOME PI METABOLISM	37	2.33e-01	-0.113000	0.54300
REACTOME APOPTOSIS	97	5.80e-02	0.112000	0.23800
REACTOME SIGNALING BY GPCR	146	2.07e-02	-0.111000	0.12900
REACTOME METABOLISM OF CARBOHYDRATES	129	3.11e-02	0.110000	0.16700
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	24	3.50e-01	0.110000	0.65800
REACTOME ACTIVATION OF GENES BY ATF4	18	4.22e-01	-0.109000	0.72300
REACTOME IRON UPTAKE AND TRANSPORT	23	3.70e-01	0.108000	0.67700
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	21	3.94e-01	0.108000	0.69900
REACTOME METABOLISM OF MRNA	177	1.42e-02	0.107000	0.09950
REACTOME CA DEPENDENT EVENTS	14	4.89e-01	-0.107000	0.76700
REACTOME G ALPHA I SIGNALLING EVENTS	30	3.14e-01	-0.106000	0.61800
REACTOME RECYCLING PATHWAY OF L1	18	4.36e-01	0.106000	0.72300
REACTOME SHC MEDIATED SIGNALLING	13	5.14e-01	0.105000	0.78600
REACTOME GPVI MEDIATED ACTIVATION CASCADE	17	4.65e-01	0.103000	0.74700
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	20	4.28e-01	-0.102000	0.72300
REACTOME NUCLEOTIDE EXCISION REPAIR	41	2.60e-01	0.102000	0.57400
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	22	4.12e-01	-0.101000	0.71800
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	100	8.27e-02	0.101000	0.28600
REACTOME RNA POL III TRANSCRIPTION TERMINATION	18	4.61e-01	0.101000	0.74700
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	189	1.81e-02	0.100000	0.11900
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	14	5.19e-01	0.099700	0.78700
REACTOME INSULIN SYNTHESIS AND PROCESSING	13	5.34e-01	-0.099600	0.78800
REACTOME REGULATION OF INSULIN SECRETION	40	2.77e-01	-0.099500	0.58300
REACTOME INWARDLY RECTIFYING K CHANNELS	11	5.71e-01	-0.098800	0.80100
REACTOME METABOLISM OF PROTEINS	302	3.68e-03	0.098100	0.04300
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	71	1.57e-01	0.097300	0.42800
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	5.33e-01	0.096200	0.78800
REACTOME SIGNALING BY ROBO RECEPTOR	19	4.72e-01	0.095300	0.75300
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	12	5.69e-01	-0.095100	0.80100
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	20	4.64e-01	-0.094700	0.74700
REACTOME SIGNALLING TO ERKS	28	3.90e-01	-0.094000	0.69600
REACTOME CELL CELL COMMUNICATION	52	2.45e-01	-0.093400	0.54900
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	60	2.13e-01	-0.093100	0.51500
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	15	5.34e-01	-0.092800	0.78800
REACTOME PLC BETA MEDIATED EVENTS	20	4.74e-01	-0.092500	0.75300
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	22	4.67e-01	-0.089600	0.74800
REACTOME MEIOSIS	27	4.23e-01	0.089100	0.72300
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	13	5.79e-01	0.088900	0.80500
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	11	6.13e-01	0.088200	0.81700
REACTOME NEPHRIN INTERACTIONS	15	5.57e-01	-0.087600	0.79700
REACTOME COSTIMULATION BY THE CD28 FAMILY	36	3.68e-01	-0.086700	0.67700
REACTOME DAG AND IP3 SIGNALING	16	5.52e-01	-0.085900	0.79700
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	21	4.98e-01	0.085400	0.76900
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	18	5.34e-01	0.084600	0.78800
REACTOME HS GAG BIOSYNTHESIS	15	5.72e-01	-0.084200	0.80100
REACTOME PI3K AKT ACTIVATION	31	4.19e-01	-0.083900	0.72200
REACTOME PROLONGED ERK ACTIVATION EVENTS	16	5.63e-01	0.083700	0.79900
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	14	5.91e-01	0.083000	0.81400
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	19	5.32e-01	-0.082800	0.78800
REACTOME SULFUR AMINO ACID METABOLISM	18	5.44e-01	0.082600	0.79700
REACTOME MRNA 3 END PROCESSING	31	4.28e-01	0.082300	0.72300
REACTOME BASIGIN INTERACTIONS	14	5.96e-01	0.081800	0.81500
REACTOME SPRY REGULATION OF FGF SIGNALING	12	6.25e-01	-0.081600	0.81700
REACTOME INTEGRATION OF ENERGY METABOLISM	63	2.65e-01	-0.081400	0.57600
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	20	5.31e-01	0.080900	0.78800
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	21	5.22e-01	-0.080800	0.78700
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	126	1.21e-01	0.080200	0.35600
REACTOME MRNA SPLICING MINOR PATHWAY	39	3.88e-01	0.080100	0.69600
REACTOME FATTY ACYL COA BIOSYNTHESIS	11	6.47e-01	0.079800	0.83200
REACTOME SHC RELATED EVENTS	14	6.06e-01	0.079700	0.81700
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	11	6.54e-01	0.078000	0.83700
REACTOME PERK REGULATED GENE EXPRESSION	20	5.47e-01	-0.077800	0.79700
REACTOME CELL JUNCTION ORGANIZATION	28	4.78e-01	-0.077600	0.75500
REACTOME REGULATION OF KIT SIGNALING	10	6.73e-01	0.077100	0.84200
REACTOME DIABETES PATHWAYS	89	2.11e-01	-0.076900	0.51400
REACTOME REGULATION OF SIGNALING BY CBL	14	6.19e-01	-0.076900	0.81700
REACTOME MITOTIC PROMETAPHASE	47	3.68e-01	0.076100	0.67700
REACTOME IMMUNE SYSTEM	520	3.54e-03	0.076000	0.04300
REACTOME DESTABILIZATION OF MRNA BY KSRP	13	6.37e-01	-0.075700	0.82100
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	81	2.42e-01	0.075400	0.54600
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	37	4.28e-01	0.075400	0.72300
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	39	4.19e-01	-0.074800	0.72200
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	31	4.75e-01	-0.074300	0.75300
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	11	6.72e-01	-0.073700	0.84200
REACTOME MEIOTIC SYNAPSIS	16	6.10e-01	-0.073700	0.81700
REACTOME SIGNALING BY FGFR	69	2.92e-01	-0.073500	0.60400
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	17	6.11e-01	0.071200	0.81700
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	40	4.37e-01	-0.071100	0.72300
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	28	5.17e-01	-0.070800	0.78700
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	107	2.07e-01	0.070800	0.50800
REACTOME G0 AND EARLY G1	13	6.60e-01	-0.070400	0.83800
REACTOME HEMOSTASIS	219	7.45e-02	-0.070400	0.26900
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	173	1.14e-01	-0.070000	0.34600
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	22	5.72e-01	0.069600	0.80100
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	13	6.66e-01	-0.069200	0.84000
REACTOME SIGNAL ATTENUATION	10	7.06e-01	-0.068800	0.85600
REACTOME SEMAPHORIN INTERACTIONS	44	4.31e-01	0.068800	0.72300
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	17	6.25e-01	0.068500	0.81700
REACTOME TRANSCRIPTION	128	1.83e-01	0.068500	0.47500
REACTOME SIGNALLING TO RAS	20	5.97e-01	-0.068400	0.81500
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	110	2.19e-01	-0.068000	0.52300
REACTOME NETRIN1 SIGNALING	21	5.91e-01	-0.067800	0.81400
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	13	6.75e-01	-0.067100	0.84300
REACTOME NOD1 2 SIGNALING PATHWAY	18	6.27e-01	-0.066200	0.81700
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	47	4.47e-01	-0.064200	0.73500
REACTOME O LINKED GLYCOSYLATION OF MUCINS	11	7.15e-01	0.063500	0.85600
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	16	6.62e-01	-0.063100	0.83800
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	42	4.80e-01	-0.063100	0.75600
REACTOME OPIOID SIGNALLING	40	4.91e-01	-0.063000	0.76700
REACTOME ADAPTIVE IMMUNE SYSTEM	340	4.95e-02	0.062700	0.22700
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	14	6.87e-01	-0.062200	0.84800
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	55	4.36e-01	-0.060800	0.72300
REACTOME P75NTR SIGNALS VIA NFKB	10	7.41e-01	0.060500	0.86500
REACTOME MRNA PROCESSING	141	2.21e-01	0.060000	0.52300
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	39	5.21e-01	-0.059400	0.78700
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	22	6.30e-01	0.059300	0.81700
REACTOME PURINE METABOLISM	26	6.04e-01	-0.058800	0.81700
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	15	7.02e-01	0.057000	0.85600
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	38	5.46e-01	0.056700	0.79700
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	10	7.58e-01	-0.056200	0.86900
REACTOME MICRORNA MIRNA BIOGENESIS	18	6.82e-01	0.055800	0.84400
REACTOME APOPTOTIC EXECUTION PHASE	27	6.21e-01	-0.055000	0.81700
REACTOME IL RECEPTOR SHC SIGNALING	15	7.13e-01	-0.054900	0.85600
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	51	5.00e-01	0.054600	0.77000
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	22	6.61e-01	0.054000	0.83800
REACTOME SIGNALING BY PDGF	86	3.94e-01	0.053300	0.69900
REACTOME TRANSCRIPTION COUPLED NER TC NER	36	5.80e-01	0.053300	0.80500
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	13	7.40e-01	0.053200	0.86500
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	33	5.99e-01	0.053000	0.81500
REACTOME CIRCADIAN CLOCK	42	5.55e-01	-0.052800	0.79700
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	56	4.97e-01	0.052500	0.76900
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	17	7.08e-01	-0.052500	0.85600
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	56	4.98e-01	-0.052500	0.76900
REACTOME ERK MAPK TARGETS	17	7.12e-01	-0.051700	0.85600
REACTOME CHOLESTEROL BIOSYNTHESIS	13	7.47e-01	0.051700	0.86700
REACTOME ACTIVATED TLR4 SIGNALLING	60	4.92e-01	-0.051400	0.76700
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	18	7.12e-01	0.050200	0.85600
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	14	7.48e-01	-0.049700	0.86700
REACTOME DARPP 32 EVENTS	17	7.24e-01	-0.049500	0.85900
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	15	7.42e-01	-0.049100	0.86500
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	45	5.70e-01	-0.049100	0.80100
REACTOME PKB MEDIATED EVENTS	27	6.60e-01	0.049000	0.83800
REACTOME VIRAL MESSENGER RNA SYNTHESIS	14	7.52e-01	0.048900	0.86700
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	50	5.52e-01	-0.048800	0.79700
REACTOME AXON GUIDANCE	145	3.13e-01	0.048700	0.61800
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	19	7.13e-01	0.048700	0.85600
REACTOME MRNA SPLICING	100	4.13e-01	0.047600	0.71800
REACTOME EFFECTS OF PIP2 HYDROLYSIS	13	7.69e-01	-0.047100	0.87500
REACTOME BOTULINUM NEUROTOXICITY	10	7.97e-01	0.047100	0.89000
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	10	7.97e-01	0.047100	0.89000
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	10	7.98e-01	-0.046900	0.89000
REACTOME INNATE IMMUNE SYSTEM	123	3.75e-01	0.046500	0.68100
REACTOME IL1 SIGNALING	25	6.89e-01	0.046300	0.84800
REACTOME GABA RECEPTOR ACTIVATION	16	7.54e-01	-0.045300	0.86700
REACTOME CHROMOSOME MAINTENANCE	38	6.30e-01	-0.045300	0.81700
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	16	7.55e-01	0.045100	0.86700
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	31	6.70e-01	-0.044200	0.84200
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	17	7.53e-01	0.044100	0.86700
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	5.60e-01	-0.044000	0.79700
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	39	6.37e-01	-0.043800	0.82100
REACTOME MYOGENESIS	21	7.30e-01	-0.043600	0.86200
REACTOME IL 2 SIGNALING	25	7.07e-01	0.043500	0.85600
REACTOME IL 3 5 AND GM CSF SIGNALING	25	7.09e-01	0.043100	0.85600
REACTOME SIGNALING BY RHO GTPASES	62	5.58e-01	-0.043100	0.79700
REACTOME SIGNALING BY ERBB2	68	5.46e-01	-0.042500	0.79700
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	50	6.04e-01	0.042400	0.81700
REACTOME L1CAM INTERACTIONS	50	6.10e-01	-0.041800	0.81700
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	31	6.92e-01	-0.041100	0.85000
REACTOME PI3K CASCADE	45	6.50e-01	-0.039200	0.83300
REACTOME LYSOSOME VESICLE BIOGENESIS	17	7.80e-01	-0.039100	0.88300
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	10	8.31e-01	0.039100	0.91600
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	16	7.90e-01	-0.038500	0.88800
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	16	7.90e-01	-0.038500	0.88800
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	71	5.76e-01	-0.038500	0.80300
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	8.20e-01	-0.037900	0.91100
REACTOME GENERIC TRANSCRIPTION PATHWAY	136	4.50e-01	-0.037700	0.73600
REACTOME RNA POL II TRANSCRIPTION	87	5.60e-01	0.036300	0.79700
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	64	6.18e-01	-0.036200	0.81700
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	5.97e-01	-0.035800	0.81500
REACTOME SIGNALING BY ERBB4	66	6.23e-01	-0.035100	0.81700
REACTOME ELONGATION ARREST AND RECOVERY	24	7.68e-01	-0.034900	0.87500
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	51	6.81e-01	0.033300	0.84400
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	28	7.77e-01	-0.031000	0.88100
REACTOME NEURONAL SYSTEM	88	6.24e-01	-0.030300	0.81700
REACTOME SIGNALING BY ILS	64	6.81e-01	0.029800	0.84400
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	13	8.58e-01	0.028700	0.93800
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	10	8.84e-01	-0.026600	0.94800
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	14	8.68e-01	0.025700	0.94100
REACTOME SIGNALING BY NOTCH1	48	7.62e-01	0.025300	0.87100
REACTOME INSULIN RECEPTOR RECYCLING	15	8.65e-01	-0.025300	0.94000
REACTOME CELL CELL JUNCTION ORGANIZATION	14	8.71e-01	-0.025000	0.94100
REACTOME KERATAN SULFATE BIOSYNTHESIS	11	8.88e-01	-0.024600	0.94900
REACTOME MRNA CAPPING	28	8.23e-01	0.024500	0.91100
REACTOME SIGNALING BY FGFR IN DISEASE	82	7.20e-01	-0.023000	0.85700
REACTOME TRIF MEDIATED TLR3 SIGNALING	52	7.86e-01	-0.021800	0.88700
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	100	7.17e-01	-0.021000	0.85600
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	97	7.27e-01	0.020600	0.86100
REACTOME METABOLISM OF PORPHYRINS	11	9.06e-01	-0.020500	0.95800
REACTOME MEMBRANE TRAFFICKING	94	7.39e-01	0.019900	0.86500
REACTOME SPHINGOLIPID METABOLISM	35	8.51e-01	-0.018300	0.93600
REACTOME METABOLISM OF NUCLEOTIDES	48	8.30e-01	0.017900	0.91600
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	17	8.99e-01	-0.017800	0.95800
REACTOME FRS2 MEDIATED CASCADE	16	9.05e-01	-0.017200	0.95800
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	27	8.77e-01	-0.017200	0.94300
REACTOME SIGNAL TRANSDUCTION BY L1	27	8.78e-01	-0.017100	0.94300
REACTOME HS GAG DEGRADATION	11	9.24e-01	0.016500	0.96800
REACTOME METABOLISM OF VITAMINS AND COFACTORS	38	8.61e-01	-0.016400	0.93800
REACTOME SIGNALING BY NOTCH	72	8.18e-01	-0.015700	0.91000
REACTOME REGULATORY RNA PATHWAYS	21	9.03e-01	-0.015300	0.95800
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	17	9.15e-01	0.014900	0.96500
REACTOME SIGNALING BY SCF KIT	58	8.58e-01	-0.013600	0.93800
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	54	8.71e-01	-0.012800	0.94100
REACTOME DEVELOPMENTAL BIOLOGY	243	7.36e-01	0.012600	0.86500
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	25	9.21e-01	-0.011500	0.96600
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	17	9.35e-01	0.011400	0.97700
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	15	9.45e-01	0.010200	0.97900
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	18	9.42e-01	-0.009930	0.97900
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	61	9.03e-01	-0.009070	0.95800
REACTOME PRE NOTCH PROCESSING IN GOLGI	14	9.55e-01	0.008750	0.98500
REACTOME SIGNALLING BY NGF	154	8.61e-01	-0.008200	0.93800
REACTOME SIGNALING BY FGFR MUTANTS	27	9.43e-01	0.007900	0.97900
REACTOME RAP1 SIGNALLING	12	9.69e-01	-0.006470	0.98800
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	95	9.18e-01	-0.006140	0.96600
REACTOME PYRIMIDINE METABOLISM	10	9.76e-01	-0.005520	0.98800
REACTOME TOLL RECEPTOR CASCADES	74	9.37e-01	0.005290	0.97800
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	11	9.77e-01	-0.005070	0.98800
REACTOME TRIGLYCERIDE BIOSYNTHESIS	21	9.74e-01	-0.004180	0.98800
REACTOME SIGNALING BY EGFR IN CANCER	83	9.50e-01	-0.004020	0.98100
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	11	9.82e-01	-0.003920	0.98800
REACTOME G ALPHA Z SIGNALLING EVENTS	20	9.77e-01	-0.003690	0.98800
REACTOME NUCLEAR SIGNALING BY ERBB4	21	9.77e-01	0.003690	0.98800
REACTOME SIGNALING BY INSULIN RECEPTOR	73	9.62e-01	-0.003250	0.98800
REACTOME SIGNALING BY FGFR1 MUTANTS	21	9.80e-01	-0.003100	0.98800
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	35	9.75e-01	0.003020	0.98800
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	59	9.82e-01	-0.001700	0.98800
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	28	9.94e-01	-0.000809	0.99700
REACTOME GABA B RECEPTOR ACTIVATION	15	9.97e-01	-0.000592	0.99700
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	50	9.96e-01	0.000391	0.99700

Detailed Gene set reports

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
	164
set	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize	13
pANOVA	5.14e-05
s.dist	-0.649
p.adjustANOVA	0.00863

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Echs1	-4517
Eci1	-4455
Acadl	-4447
Hadhb	-4260
Acadvl	-4256
Hadha	-4073
Decr1	-3717
Mcee	-3614
Pcca	-2779
Acadm	-2757
Hadh	-2553
Pccb	-713
Acads	2096

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Echs1	-4517
Eci1	-4455
Acadl	-4447
Hadhb	-4260
Acadvl	-4256
Hadha	-4073
Decr1	-3717
Mcee	-3614
Pcca	-2779
Acadm	-2757
Hadh	-2553
Pccb	-713
Acads	2096

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
	1
set	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
setSize	11
pANOVA	0.00215
s.dist	0.535
p.adjustANOVA	0.032

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Phka1	4647
Phkb	3658
Phka2	3578
Phkg2	3485
Phkg1	3471
Pygm	3272
Pgm1	3147
Agl	2677
Gyg	2648
Pygb	657
Calm1	-3571

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Phka1	4647
Phkb	3658
Phka2	3578
Phkg2	3485
Phkg1	3471
Pygm	3272
Pgm1	3147
Agl	2677
Gyg	2648
Pygb	657
Calm1	-3571

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
	226
set	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
setSize	16
pANOVA	6e-04
s.dist	0.496
p.adjustANOVA	0.0185

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Grip2	4712
Nsf	4479
Myo6	4331
Camk2a	4118
Ap2s1	3986
Camk2b	3005
Camk2d	2794
Prkca	2732
Dlg1	2506
Pick1	2318
Ap2a1	2264
Ap2b1	2094
Mdm2	1904
Epb41l1	-686
Ap2a2	-907
Ap2m1	-2367

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Grip2	4712
Nsf	4479
Myo6	4331
Camk2a	4118
Ap2s1	3986
Camk2b	3005
Camk2d	2794
Prkca	2732
Dlg1	2506
Pick1	2318
Ap2a1	2264
Ap2b1	2094
Mdm2	1904
Epb41l1	-686
Ap2a2	-907
Ap2m1	-2367

REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION

REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
	174
set	REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
setSize	20
pANOVA	0.000126
s.dist	0.495
p.adjustANOVA	0.0102

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Lars2	4714.0
Cars2	4244.0
Ears2	4192.0
Gars	3896.0
Qars	3891.0
Rars2	3639.0
Hars2	3611.0
Sars2	3321.0
Dars2	3054.0
Iars2	2598.0
Aars2	2072.0
Kars	1940.0
Tars2	1514.0
Ppa2	1419.0
Wars2	1284.0
Nars2	916.0
Yars2	607.0
Fars2	542.0
Vars2	-325.5
Mars2	-563.0

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Lars2	4714.0
Cars2	4244.0
Ears2	4192.0
Gars	3896.0
Qars	3891.0
Rars2	3639.0
Hars2	3611.0
Sars2	3321.0
Dars2	3054.0
Iars2	2598.0
Aars2	2072.0
Kars	1940.0
Tars2	1514.0
Ppa2	1419.0
Wars2	1284.0
Nars2	916.0
Yars2	607.0
Fars2	542.0
Vars2	-325.5
Mars2	-563.0

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
	218
set	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
setSize	19
pANOVA	0.0042
s.dist	-0.38
p.adjustANOVA	0.0474

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nnt	-4744
Idh2	-4472
Sdhb	-4353
Ogdh	-3557
Cs	-3215
Idh3a	-2587
Idh3b	-2403
Suclg1	-2232
Mdh2	-1843
Sdha	-1591
Idh3g	-1196
Sucla2	-1077
Fh1	-1042
Dld	-611
Sdhc	-559
Dlst	-360
Suclg2	-324
Aco2	567
Sdhd	1271

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nnt	-4744
Idh2	-4472
Sdhb	-4353
Ogdh	-3557
Cs	-3215
Idh3a	-2587
Idh3b	-2403
Suclg1	-2232
Mdh2	-1843
Sdha	-1591
Idh3g	-1196
Sucla2	-1077
Fh1	-1042
Dld	-611
Sdhc	-559
Dlst	-360
Suclg2	-324
Aco2	567
Sdhd	1271

REACTOME_NCAM1_INTERACTIONS

REACTOME_NCAM1_INTERACTIONS
	227
set	REACTOME_NCAM1_INTERACTIONS
setSize	18
pANOVA	0.00561
s.dist	0.377
p.adjustANOVA	0.056

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Col3a1	4556
Col1a2	4485
Col1a1	4396
Col6a3	4058
Prnp	3759
Col6a1	3751
Col5a2	3503
Col5a1	3299
Nrtn	3198
Col4a1	2559
Col4a2	2388
Agrn	1913
St8sia4	979
Col6a2	850
Gfra1	537
Cacna1s	-3829
Cacnb1	-4157
Col9a1	-4387

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Col3a1	4556
Col1a2	4485
Col1a1	4396
Col6a3	4058
Prnp	3759
Col6a1	3751
Col5a2	3503
Col5a1	3299
Nrtn	3198
Col4a1	2559
Col4a2	2388
Agrn	1913
St8sia4	979
Col6a2	850
Gfra1	537
Cacna1s	-3829
Cacnb1	-4157
Col9a1	-4387

REACTOME_INTERFERON_GAMMA_SIGNALING

REACTOME_INTERFERON_GAMMA_SIGNALING
	358
set	REACTOME_INTERFERON_GAMMA_SIGNALING
setSize	24
pANOVA	0.00139
s.dist	0.377
p.adjustANOVA	0.028

Top enriched genes

Top 20 genes
GeneID	Gene Rank
H2-Aa	4703
Prkcd	4633
Irf3	4600
H2-Eb1	4595
Ptpn2	4516
Irf9	4488
Camk2a	4118
Sumo1	3669
Camk2b	3005
Camk2d	2794
Jak1	2315
Jak2	1923
Ptpn1	1765
Irf2	1731
Gbp7	1452
Irf8	1196
Ifngr1	1037
B2m	44
Irf5	-162
Stat1	-189

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
H2-Aa	4703.0
Prkcd	4633.0
Irf3	4600.0
H2-Eb1	4595.0
Ptpn2	4516.0
Irf9	4488.0
Camk2a	4118.0
Sumo1	3669.0
Camk2b	3005.0
Camk2d	2794.0
Jak1	2315.0
Jak2	1923.0
Ptpn1	1765.0
Irf2	1731.0
Gbp7	1452.0
Irf8	1196.0
Ifngr1	1037.0
B2m	44.0
Irf5	-162.0
Stat1	-189.0
Ifngr2	-1206.0
Cd44	-2188.5
Irf1	-2951.0
Pias1	-3445.0

REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A

REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A
	447
set	REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A
setSize	17
pANOVA	0.013
s.dist	0.348
p.adjustANOVA	0.0949

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Rps27a	3650
Anapc5	3591
Anapc2	3257
Bub3	2486
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Rps27a	3650
Anapc5	3591
Anapc2	3257
Bub3	2486
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

REACTOME_COMPLEMENT_CASCADE

REACTOME_COMPLEMENT_CASCADE
	425
set	REACTOME_COMPLEMENT_CASCADE
setSize	11
pANOVA	0.0459
s.dist	0.348
p.adjustANOVA	0.219

Top enriched genes

Top 20 genes
GeneID	Gene Rank
C4b	4659
C1qb	4412
C1qa	3895
Cd46	3142
C3	2948
C1qc	2702
Cfd	2317
C7	1462
Pros1	-1159
C1s1	-2460
Cr1l	-3972

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
C4b	4659
C1qb	4412
C1qa	3895
Cd46	3142
C3	2948
C1qc	2702
Cfd	2317
C7	1462
Pros1	-1159
C1s1	-2460
Cr1l	-3972

REACTOME_TRNA_AMINOACYLATION

REACTOME_TRNA_AMINOACYLATION
	185
set	REACTOME_TRNA_AMINOACYLATION
setSize	39
pANOVA	0.00019
s.dist	0.346
p.adjustANOVA	0.011

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Lars2	4714
Cars	4297
Cars2	4244
Ears2	4192
Gars	3896
Qars	3891
Tars	3881
Aimp2	3863
Rars2	3639
Hars2	3611
Vars	3482
Sars2	3321
Eprs	3070
Dars2	3054
Iars2	2598
Lars	2307
Aars2	2072
Kars	1940
Nars	1799
Rars	1764

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Lars2	4714.0
Cars	4297.0
Cars2	4244.0
Ears2	4192.0
Gars	3896.0
Qars	3891.0
Tars	3881.0
Aimp2	3863.0
Rars2	3639.0
Hars2	3611.0
Vars	3482.0
Sars2	3321.0
Eprs	3070.0
Dars2	3054.0
Iars2	2598.0
Lars	2307.0
Aars2	2072.0
Kars	1940.0
Nars	1799.0
Rars	1764.0
Tars2	1514.0
Ppa2	1419.0
Wars2	1284.0
Aimp1	1009.0
Nars2	916.0
Yars2	607.0
Fars2	542.0
Farsa	130.0
Hars	-112.0
Ppa1	-190.0
Vars2	-325.5
Iars	-490.0
Mars2	-563.0
Dars	-759.0
Farsb	-889.0
Aars	-1031.0
Wars	-1242.0
Yars	-1916.0
Sars	-2462.0

REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS

REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
	382
set	REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
setSize	11
pANOVA	0.0523
s.dist	-0.338
p.adjustANOVA	0.227

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ppp1cb	-4733
Cav1	-4672
Fabp4	-4222
Abhd5	-3993
Lipe	-3828
Prkaca	-2964
Mgll	-2855
Prkacb	559
Ppp1cc	1850
Ppp1ca	2922
Plin1	4205

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ppp1cb	-4733
Cav1	-4672
Fabp4	-4222
Abhd5	-3993
Lipe	-3828
Prkaca	-2964
Mgll	-2855
Prkacb	559
Ppp1cc	1850
Ppp1ca	2922
Plin1	4205

REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA

REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
	253
set	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
setSize	12
pANOVA	0.0428
s.dist	-0.338
p.adjustANOVA	0.211

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gnb5	-4675
Gnb4	-4606
Pdpk1	-4591
Akt3	-4385
Gng5	-3962
Akt1	-2769
Gnb1	-1636
Gnb2	303
Akt2	487
Gng11	719
Gng10	2856
Gng12	2931

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gnb5	-4675
Gnb4	-4606
Pdpk1	-4591
Akt3	-4385
Gng5	-3962
Akt1	-2769
Gnb1	-1636
Gnb2	303
Akt2	487
Gng11	719
Gng10	2856
Gng12	2931

REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B

REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B
	415
set	REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B
setSize	16
pANOVA	0.0198
s.dist	0.337
p.adjustANOVA	0.126

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Rps27a	3650
Anapc5	3591
Anapc2	3257
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Rps27a	3650
Anapc5	3591
Anapc2	3257
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
	131
set	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
setSize	11
pANOVA	0.0546
s.dist	-0.335
p.adjustANOVA	0.228

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdk4	-4684
Pdp2	-4549
Pdk2	-3065
Pdha1	-2959
Pdpr	-2913
Dlat	-2905
Pdk1	-2458
Pdhb	-671
Dld	-611
Pdhx	2669
Pdp1	4582

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdk4	-4684
Pdp2	-4549
Pdk2	-3065
Pdha1	-2959
Pdpr	-2913
Dlat	-2905
Pdk1	-2458
Pdhb	-671
Dld	-611
Pdhx	2669
Pdp1	4582

REACTOME_ADP_SIGNALLING_THROUGH_P2RY1

REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
	243
set	REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
setSize	12
pANOVA	0.0481
s.dist	-0.33
p.adjustANOVA	0.227

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gnb5	-4675
Gnb4	-4606
P2ry1	-4183
Gng5	-3962
Gna11	-3736
Mapk14	-1895
Gnb1	-1636
Gnaq	-981
Gnb2	303
Gng11	719
Gng10	2856
Gng12	2931

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gnb5	-4675
Gnb4	-4606
P2ry1	-4183
Gng5	-3962
Gna11	-3736
Mapk14	-1895
Gnb1	-1636
Gnaq	-981
Gnb2	303
Gng11	719
Gng10	2856
Gng12	2931

REACTOME_MEIOTIC_RECOMBINATION

REACTOME_MEIOTIC_RECOMBINATION
	372
set	REACTOME_MEIOTIC_RECOMBINATION
setSize	11
pANOVA	0.0616
s.dist	0.326
p.adjustANOVA	0.247

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdk2	4419
Mlh3	4189
Rad50	3012
Rpa2	2591
Rpa1	2227
Atm	1491
Mlh1	1300
Nbn	300
Cdk4	-82
H3f3b	-752
Top3a	-1899

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdk2	4419
Mlh3	4189
Rad50	3012
Rpa2	2591
Rpa1	2227
Atm	1491
Mlh1	1300
Nbn	300
Cdk4	-82
H3f3b	-752
Top3a	-1899

REACTOME_SMOOTH_MUSCLE_CONTRACTION

REACTOME_SMOOTH_MUSCLE_CONTRACTION
	277
set	REACTOME_SMOOTH_MUSCLE_CONTRACTION
setSize	19
pANOVA	0.0162
s.dist	-0.319
p.adjustANOVA	0.112

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tpm2	-4743
Sorbs1	-4693
Tpm3	-4509
Mylk	-4407
Myl9	-4380
Itga1	-3766
Calm1	-3571
Acta2	-3366
Myl6b	-2804
Tln1	-2758
Tpm4	-2038
Cald1	-1838
Itgb5	-1377
Myh11	-924
Vcl	2877
Myl12b	3042
Sorbs3	3057
Myl6	3416
Tpm1	3922

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tpm2	-4743
Sorbs1	-4693
Tpm3	-4509
Mylk	-4407
Myl9	-4380
Itga1	-3766
Calm1	-3571
Acta2	-3366
Myl6b	-2804
Tln1	-2758
Tpm4	-2038
Cald1	-1838
Itgb5	-1377
Myh11	-924
Vcl	2877
Myl12b	3042
Sorbs3	3057
Myl6	3416
Tpm1	3922

REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING

REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
	262
set	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
setSize	13
pANOVA	0.0492
s.dist	-0.315
p.adjustANOVA	0.227

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gnb5	-4675
Gnb4	-4606
Pdpk1	-4591
Akt3	-4385
Gng5	-3962
Akt1	-2769
Gnb1	-1636
Plcb3	-216
Gnb2	303
Akt2	487
Gng11	719
Gng10	2856
Gng12	2931

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gnb5	-4675
Gnb4	-4606
Pdpk1	-4591
Akt3	-4385
Gng5	-3962
Akt1	-2769
Gnb1	-1636
Plcb3	-216
Gnb2	303
Akt2	487
Gng11	719
Gng10	2856
Gng12	2931

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
	5
set	REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
setSize	38
pANOVA	0.000947
s.dist	-0.31
p.adjustANOVA	0.0247

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nnt	-4744
Pdk4	-4684
Pdp2	-4549
Ldhb	-4478
Idh2	-4472
Sdhb	-4353
Ogdh	-3557
Adhfe1	-3538
Cs	-3215
Pdk2	-3065
Pdha1	-2959
Pdpr	-2913
Dlat	-2905
Idh3a	-2587
Pdk1	-2458
Idh3b	-2403
Suclg1	-2232
Mdh2	-1843
Sdha	-1591
Idh1	-1312

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nnt	-4744
Pdk4	-4684
Pdp2	-4549
Ldhb	-4478
Idh2	-4472
Sdhb	-4353
Ogdh	-3557
Adhfe1	-3538
Cs	-3215
Pdk2	-3065
Pdha1	-2959
Pdpr	-2913
Dlat	-2905
Idh3a	-2587
Pdk1	-2458
Idh3b	-2403
Suclg1	-2232
Mdh2	-1843
Sdha	-1591
Idh1	-1312
Idh3g	-1196
Sucla2	-1077
Fh1	-1042
Slc16a1	-925
Pdhb	-671
Dld	-611
Sdhc	-559
Ldha	-545
Dlst	-360
Suclg2	-324
Bsg	67
D2hgdh	349
Aco2	567
L2hgdh	957
Sdhd	1271
Pdhx	2669
Pdp1	4582
Slc16a3	4615

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
	269
set	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
setSize	16
pANOVA	0.0373
s.dist	-0.301
p.adjustANOVA	0.192

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aldh6a1	-4725
Acat1	-4548
Ivd	-4220
Mccc2	-4129
Dbt	-3872
Hibch	-3633
Hibadh	-1784
Bckdha	-1639
Auh	-1145
Hsd17b10	-982
Bcat2	-756
Bckdhb	-643
Dld	-611
Mccc1	3129
Acadsb	3204
Acad8	3389

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aldh6a1	-4725
Acat1	-4548
Ivd	-4220
Mccc2	-4129
Dbt	-3872
Hibch	-3633
Hibadh	-1784
Bckdha	-1639
Auh	-1145
Hsd17b10	-982
Bcat2	-756
Bckdhb	-643
Dld	-611
Mccc1	3129
Acadsb	3204
Acad8	3389

REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC

REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC
	200
set	REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC
setSize	19
pANOVA	0.0234
s.dist	0.301
p.adjustANOVA	0.141

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pfdn1	4390
Tubb4b	4389
Actb	3789
Tubb2a	3592
Tuba4a	3132
Cct7	2945
Cct5	2895
Pfdn6	2622
Tubb6	2112
Tuba1a	2049
Pfdn5	1964
Tcp1	1483
Cct8	1261
Cct3	978
Pfdn2	-231
Cct4	-358
Pfdn4	-2215
Vbp1	-3824
Cct2	-4235

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pfdn1	4390
Tubb4b	4389
Actb	3789
Tubb2a	3592
Tuba4a	3132
Cct7	2945
Cct5	2895
Pfdn6	2622
Tubb6	2112
Tuba1a	2049
Pfdn5	1964
Tcp1	1483
Cct8	1261
Cct3	978
Pfdn2	-231
Cct4	-358
Pfdn4	-2215
Vbp1	-3824
Cct2	-4235

REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE

REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE
	420
set	REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE
setSize	15
pANOVA	0.0446
s.dist	0.3
p.adjustANOVA	0.217

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ube2c	4268
Cdc14a	4034
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Anapc5	3591
Anapc2	3257
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ube2c	4268
Cdc14a	4034
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Anapc5	3591
Anapc2	3257
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC

REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
	203
set	REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
setSize	13
pANOVA	0.0628
s.dist	0.298
p.adjustANOVA	0.247

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb4b	4389
Tubb2a	3592
Tuba4a	3132
Cct7	2945
Cct5	2895
Tubb6	2112
Tuba1a	2049
Tcp1	1483
Cct8	1261
Cct3	978
Cct4	-358
Tuba1b	-2085
Cct2	-4235

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb4b	4389
Tubb2a	3592
Tuba4a	3132
Cct7	2945
Cct5	2895
Tubb6	2112
Tuba1a	2049
Tcp1	1483
Cct8	1261
Cct3	978
Cct4	-358
Tuba1b	-2085
Cct2	-4235

REACTOME_SIGNALING_BY_NODAL

REACTOME_SIGNALING_BY_NODAL
	21
set	REACTOME_SIGNALING_BY_NODAL
setSize	11
pANOVA	0.091
s.dist	-0.294
p.adjustANOVA	0.297

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pcsk6	-4302
Smad2	-4145
Foxo3	-3916
Smad3	-3891
Acvr2b	-3416
Smad4	-2795
Cers1	-2247
Acvr1b	-406
Acvr2a	2381
Furin	3464
Drap1	3814

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pcsk6	-4302
Smad2	-4145
Foxo3	-3916
Smad3	-3891
Acvr2b	-3416
Smad4	-2795
Cers1	-2247
Acvr1b	-406
Acvr2a	2381
Furin	3464
Drap1	3814

REACTOME_SYNTHESIS_OF_PA

REACTOME_SYNTHESIS_OF_PA
	101
set	REACTOME_SYNTHESIS_OF_PA
setSize	12
pANOVA	0.0881
s.dist	-0.284
p.adjustANOVA	0.294

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pla2g12a	-4664
Gpam	-4605
Pld2	-4502
Agpat3	-4227
Pld1	-3948
Pla2g5	-2788
Gnpat	-2762
Gpd1l	-2404
Agpat5	2795
Lclat1	3255
Agpat1	3512
Gpd1	4039

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pla2g12a	-4664
Gpam	-4605
Pld2	-4502
Agpat3	-4227
Pld1	-3948
Pla2g5	-2788
Gnpat	-2762
Gpd1l	-2404
Agpat5	2795
Lclat1	3255
Agpat1	3512
Gpd1	4039

REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6

REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
	121
set	REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
setSize	41
pANOVA	0.00167
s.dist	0.284
p.adjustANOVA	0.0308

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Psma3	1880
Psmc4	1703
Psmd3	1399
Psmb7	1044
Psmd5	1034
Psmb1	894
Psmb2	810
Psmd2	612
Psmd9	522
Psmd10	399
Psmc2	372
Psma6	-788
Psma1	-955
Psmb10	-1714
Psmb4	-1742
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Psma7	-2870
Psma2	-3605
Psme1	-3960

REACTOME_METABOLISM_OF_POLYAMINES

REACTOME_METABOLISM_OF_POLYAMINES
	167
set	REACTOME_METABOLISM_OF_POLYAMINES
setSize	12
pANOVA	0.0903
s.dist	0.282
p.adjustANOVA	0.297

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Smox	4646
Sat1	4340
Odc1	3980
Enoph1	3953
Sms	3920
Amd1	2756
Adi1	2209
Mtap	-1130
Mri1	-1549
Srm	-1878
Apip	-2320
Got1	-3051

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Smox	4646
Sat1	4340
Odc1	3980
Enoph1	3953
Sms	3920
Amd1	2756
Adi1	2209
Mtap	-1130
Mri1	-1549
Srm	-1878
Apip	-2320
Got1	-3051

REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS

REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS
	395
set	REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS
setSize	24
pANOVA	0.0168
s.dist	0.282
p.adjustANOVA	0.115

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nup93	4501
Nup85	4457
Nup43	3798
Rae1	3679
Nup62	3417
Kpnb1	3023
Kpna1	2950
Seh1l	2909
Nup188	2498
Nup107	1846
Nup205	1409
Nup37	1397
Nup88	953
Ranbp2	780
Nupl2	604
Nup133	453
Nup210	184
Pom121	87
Tpr	-103
Nup155	-245

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nup93	4501
Nup85	4457
Nup43	3798
Rae1	3679
Nup62	3417
Kpnb1	3023
Kpna1	2950
Seh1l	2909
Nup188	2498
Nup107	1846
Nup205	1409
Nup37	1397
Nup88	953
Ranbp2	780
Nupl2	604
Nup133	453
Nup210	184
Pom121	87
Tpr	-103
Nup155	-245
Nup35	-291
Nup214	-378
Nup153	-3017
Nup54	-3248

REACTOME_ION_CHANNEL_TRANSPORT

REACTOME_ION_CHANNEL_TRANSPORT
	366
set	REACTOME_ION_CHANNEL_TRANSPORT
setSize	18
pANOVA	0.0387
s.dist	-0.282
p.adjustANOVA	0.195

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp2a2	-4686
Atp1a2	-4660
Atp1a1	-3453
Arhgef9	-3397
Atp1b1	-3124
Atp2a3	-2218
Atp11b	-1924
Atp2b3	-1688
Atp11c	-1683
Atp7a	-1550
Atp2c1	-1544
Atp1b3	-747
Atp2a1	-311
Atp11a	-60
Atp1b2	685
Atp9a	1417
Atp8a1	1869
Atp9b	2886

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp2a2	-4686
Atp1a2	-4660
Atp1a1	-3453
Arhgef9	-3397
Atp1b1	-3124
Atp2a3	-2218
Atp11b	-1924
Atp2b3	-1688
Atp11c	-1683
Atp7a	-1550
Atp2c1	-1544
Atp1b3	-747
Atp2a1	-311
Atp11a	-60
Atp1b2	685
Atp9a	1417
Atp8a1	1869
Atp9b	2886

REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE

REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE
	193
set	REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE
setSize	47
pANOVA	0.000921
s.dist	0.28
p.adjustANOVA	0.0247

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Cdkn1b	1928
Mdm2	1904
Psma3	1880
Psmc4	1703
Atm	1491
Psmd3	1399
Psmb7	1044
Psmd5	1034
Psmb1	894
Psmb2	810
Psmd2	612
Trp53	536
Psmd9	522
Psmd10	399
Psmc2	372
Psma6	-788
Psma1	-955
Psmb10	-1714
Psmb4	-1742
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Psma7	-2870
Ccne2	-3495
Psma2	-3605
Psme1	-3960

REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS

REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS
	4
set	REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS
setSize	15
pANOVA	0.0625
s.dist	0.278
p.adjustANOVA	0.247

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Anapc5	3591
Anapc2	3257
Bub3	2486
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Anapc5	3591
Anapc2	3257
Bub3	2486
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS

REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS
	119
set	REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS
setSize	44
pANOVA	0.00151
s.dist	-0.277
p.adjustANOVA	0.0292

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dgat2	-4742
Pla2g12a	-4664
Chpt1	-4637
Lpgat1	-4613
Gpam	-4605
Pld2	-4502
Pnpla2	-4306
Hadhb	-4260
Agpat3	-4227
Mboat7	-4182
Hadha	-4073
Pld1	-3948
Crls1	-3705
Chkb	-3483
Etnk1	-3238
Mgll	-2855
Pla2g5	-2788
Pitpnb	-2785
Gnpat	-2762
Plbd1	-2689

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dgat2	-4742
Pla2g12a	-4664
Chpt1	-4637
Lpgat1	-4613
Gpam	-4605
Pld2	-4502
Pnpla2	-4306
Hadhb	-4260
Agpat3	-4227
Mboat7	-4182
Hadha	-4073
Pld1	-3948
Crls1	-3705
Chkb	-3483
Etnk1	-3238
Mgll	-2855
Pla2g5	-2788
Pitpnb	-2785
Gnpat	-2762
Plbd1	-2689
Pnpla8	-2675
Cept1	-2405
Gpd1l	-2404
Dgat1	-2105
Gpcpd1	-1862
Cds2	-1553
Ptdss2	-860
Slc44a2	-706
Lpin1	-215
Slc44a1	-156
Pla2g6	137
Cdipt	166
Ache	257
Phospho1	1558
Ptdss1	2207
Pcyt2	2246
Agpat5	2795
Lpcat3	2953
Pld3	2995
Lclat1	3255
Agpat1	3512
Pgs1	3934
Pcyt1a	3993
Gpd1	4039

REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS
	235
set	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS
setSize	22
pANOVA	0.0253
s.dist	-0.276
p.adjustANOVA	0.146

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gnb5	-4675
Ramp1	-4625
Gnb4	-4606
Crhr2	-4579
Fzd4	-4483
Fzd9	-4366
Ramp2	-4077
Gng5	-3962
Calcrl	-3896
Wnt11	-1889
Fzd7	-1666
Gnb1	-1636
Gnas	-1504
Ptch1	154
Gnb2	303
Gng11	719
Sctr	1358
Smo	1983
Wnt9a	2577
Gng10	2856

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gnb5	-4675
Ramp1	-4625
Gnb4	-4606
Crhr2	-4579
Fzd4	-4483
Fzd9	-4366
Ramp2	-4077
Gng5	-3962
Calcrl	-3896
Wnt11	-1889
Fzd7	-1666
Gnb1	-1636
Gnas	-1504
Ptch1	154
Gnb2	303
Gng11	719
Sctr	1358
Smo	1983
Wnt9a	2577
Gng10	2856
Gng12	2931
Wnt4	4142

REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN
	413
set	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN
setSize	23
pANOVA	0.0227
s.dist	0.275
p.adjustANOVA	0.138

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nup93	4501
Nup85	4457
Gck	3844
Nup43	3798
Rae1	3679
Nup62	3417
Seh1l	2909
Nup188	2498
Nup107	1846
Nup205	1409
Nup37	1397
Nup88	953
Ranbp2	780
Nupl2	604
Nup133	453
Nup210	184
Pom121	87
Tpr	-103
Nup155	-245
Nup35	-291

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nup93	4501
Nup85	4457
Gck	3844
Nup43	3798
Rae1	3679
Nup62	3417
Seh1l	2909
Nup188	2498
Nup107	1846
Nup205	1409
Nup37	1397
Nup88	953
Ranbp2	780
Nupl2	604
Nup133	453
Nup210	184
Pom121	87
Tpr	-103
Nup155	-245
Nup35	-291
Nup214	-378
Nup153	-3017
Nup54	-3248

REACTOME_PLATELET_HOMEOSTASIS

REACTOME_PLATELET_HOMEOSTASIS
	339
set	REACTOME_PLATELET_HOMEOSTASIS
setSize	33
pANOVA	0.00713
s.dist	-0.271
p.adjustANOVA	0.066

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp2a2	-4686
Gnb5	-4675
Gnb4	-4606
Ppp2ca	-4535
Prkg1	-4490
Stim1	-4358
Gng5	-3962
Itpr2	-3105
Ppp2cb	-3018
Nos1	-2732
Atp2a3	-2218
Mapk14	-1895
Ppp2r5e	-1829
Pecam1	-1693
Atp2b3	-1688
Gnb1	-1636
Gnas	-1504
Pde2a	-1468
Ppp2r5a	-875
Ppp2r5c	-852

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp2a2	-4686
Gnb5	-4675
Gnb4	-4606
Ppp2ca	-4535
Prkg1	-4490
Stim1	-4358
Gng5	-3962
Itpr2	-3105
Ppp2cb	-3018
Nos1	-2732
Atp2a3	-2218
Mapk14	-1895
Ppp2r5e	-1829
Pecam1	-1693
Atp2b3	-1688
Gnb1	-1636
Gnas	-1504
Pde2a	-1468
Ppp2r5a	-875
Ppp2r5c	-852
Ppp2r5d	-661
Nos3	-433
Atp2a1	-311
Gnb2	303
Slc8a1	644
Ppp2r1b	671
Gng11	719
Ppp2r1a	809
Orai1	966
Ppp2r5b	1218
Gng10	2856
Gng12	2931
Slc8a3	3500

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
	340
set	REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
setSize	13
pANOVA	0.0924
s.dist	0.27
p.adjustANOVA	0.297

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mogs	4442
Mlec	3963
Prkcsh	3918
Edem2	3277
Man1b1	2831
Calr	1922
Edem3	1239
Ganab	1171
Uggt2	1163
Uggt1	-284
Edem1	-696
Canx	-2459
Pdia3	-4075

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mogs	4442
Mlec	3963
Prkcsh	3918
Edem2	3277
Man1b1	2831
Calr	1922
Edem3	1239
Ganab	1171
Uggt2	1163
Uggt1	-284
Edem1	-696
Canx	-2459
Pdia3	-4075

REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21

REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21
	451
set	REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21
setSize	44
pANOVA	0.00202
s.dist	0.269
p.adjustANOVA	0.0318

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Cdkn1b	1928
Psma3	1880
Psmc4	1703
Psmd3	1399
Psmb7	1044
Psmd5	1034
Psmb1	894
Psmb2	810
Psmd2	612
Psmd9	522
Psmd10	399
Cul1	387
Psmc2	372
Psma6	-788
Psma1	-955
Psmb10	-1714
Psmb4	-1742
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Psma7	-2870
Ccne2	-3495
Psma2	-3605
Psme1	-3960

REACTOME_CELL_CYCLE_CHECKPOINTS

REACTOME_CELL_CYCLE_CHECKPOINTS
	180
set	REACTOME_CELL_CYCLE_CHECKPOINTS
setSize	80
pANOVA	3.43e-05
s.dist	0.268
p.adjustANOVA	0.00863

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Ube2c	4268
Psmd13	4085
Atrip	4079
Psmd7	4049
Anapc4	3998
Ube2e1	3971
Psmd8	3928
Anapc1	3852
Rad1	3747
Rps27a	3650
Anapc5	3591
Rfc2	3392
Psmb5	3295
Anapc2	3257

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdkn1a	4587.0
Uba52	4579.0
Psmf1	4511.0
Psmc3	4504.0
Psmc5	4433.0
Cdk2	4419.0
Ube2c	4268.0
Psmd13	4085.0
Atrip	4079.0
Psmd7	4049.0
Anapc4	3998.0
Ube2e1	3971.0
Psmd8	3928.0
Anapc1	3852.0
Rad1	3747.0
Rps27a	3650.0
Anapc5	3591.0
Rfc2	3392.0
Psmb5	3295.0
Anapc2	3257.0
Orc2	3164.0
Psmd1	3144.0
Psma4	2904.0
Psmd14	2804.0
Psmb6	2786.0
Rpa2	2591.0
Psmc1	2564.0
Psme4	2507.0
Bub3	2486.0
Psmd4	2427.0
Psmd12	2276.0
Psma5	2271.0
Rpa1	2227.0
Psmd6	2193.0
Mad1l1	2024.5
Cdkn1b	1928.0
Mdm2	1904.0
Psma3	1880.0
Orc4	1758.0
Psmc4	1703.0
Cdc23	1675.0
Rad17	1659.0
Atm	1491.0
Mcm4	1477.0
Psmd3	1399.0
Mcm7	1270.0
Ube2d1	1133.0
Psmb7	1044.0
Psmd5	1034.0
Atr	993.0
Orc3	965.0
Psmb1	894.0
Psmb2	810.0
Psmd2	612.0
Trp53	536.0
Hus1	526.0
Psmd9	522.0
Psmd10	399.0
Psmc2	372.0
Cdc16	-429.0
Anapc7	-447.0
Mcm2	-719.0
Psma6	-788.0
Psma1	-955.0
Cdc25a	-1567.0
Anapc10	-1647.0
Cdc27	-1670.0
Psmb10	-1714.0
Psmb4	-1742.0
Anapc11	-1946.0
Cdc26	-2581.0
Psmd11	-2582.0
Psmb3	-2692.0
Psmc6	-2706.0
Psma7	-2870.0
Ccne2	-3495.0
Psma2	-3605.0
Psme1	-3960.0
Orc5	-3984.0
Rfc4	-4638.0

REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS

REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS
	152
set	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS
setSize	11
pANOVA	0.125
s.dist	0.267
p.adjustANOVA	0.358

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sqstm1	4618
Uba52	4579
Rps27a	3650
Psenen	3382
Itgb3bp	3135
Psen2	895
Ncstn	84
Traf6	78
Psen1	-1229
Mapk8	-2212
Aph1a	-3208

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sqstm1	4618
Uba52	4579
Rps27a	3650
Psenen	3382
Itgb3bp	3135
Psen2	895
Ncstn	84
Traf6	78
Psen1	-1229
Mapk8	-2212
Aph1a	-3208

REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1

REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1
	276
set	REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1
setSize	42
pANOVA	0.00296
s.dist	0.265
p.adjustANOVA	0.0415

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Psma3	1880

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Psma3	1880
Psmc4	1703
Atm	1491
Psmd3	1399
Psmb7	1044
Psmd5	1034
Psmb1	894
Psmb2	810
Psmd2	612
Trp53	536
Psmd9	522
Psmd10	399
Psmc2	372
Psma6	-788
Psma1	-955
Psmb10	-1714
Psmb4	-1742
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Psma7	-2870
Psma2	-3605
Psme1	-3960

REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES

REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES
	178
set	REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES
setSize	38
pANOVA	0.00473
s.dist	0.265
p.adjustANOVA	0.0498

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb4b	4389
Dctn3	4266
Cep63	4248
Dctn2	3696
Dync1i2	3584
Tubb5	3551
Cep250	3383
Csnk1e	3140
Tuba4a	3132
Haus2	3123
Actr1a	2851
Ofd1	2788
Ckap5	2659
Cetn2	2575
Clasp1	2331
Ywhag	2263
Tuba1a	2049
Dynll1	1646
Mapre1	1606
Pcm1	1599

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb4b	4389
Dctn3	4266
Cep63	4248
Dctn2	3696
Dync1i2	3584
Tubb5	3551
Cep250	3383
Csnk1e	3140
Tuba4a	3132
Haus2	3123
Actr1a	2851
Ofd1	2788
Ckap5	2659
Cetn2	2575
Clasp1	2331
Ywhag	2263
Tuba1a	2049
Dynll1	1646
Mapre1	1606
Pcm1	1599
Cep76	1476
Ywhae	1156
Cntrl	1015
Ppp2r1a	809
Ssna1	677
Akap9	519
Pafah1b1	276
Pcnt	207
Nedd1	113
Sdccag8	-105
Dctn1	-587
Dync1h1	-617
Cdk5rap2	-1210
Cep57	-1991
Tubg1	-2659
Csnk1d	-2720
Cep290	-4057
Hsp90aa1	-4168

REACTOME_METAL_ION_SLC_TRANSPORTERS

REACTOME_METAL_ION_SLC_TRANSPORTERS
	275
set	REACTOME_METAL_ION_SLC_TRANSPORTERS
setSize	12
pANOVA	0.113
s.dist	-0.265
p.adjustANOVA	0.345

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Slc41a1	-4726
Slc31a1	-4343
Slc30a5	-3691
Slc39a7	-3429
Slc30a1	-3011
Slc39a1	-2288
Slc39a3	-1007
Slc39a10	-197
Cp	473
Slc30a7	1848
Slc40a1	2579
Slc30a2	2617

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Slc41a1	-4726
Slc31a1	-4343
Slc30a5	-3691
Slc39a7	-3429
Slc30a1	-3011
Slc39a1	-2288
Slc39a3	-1007
Slc39a10	-197
Cp	473
Slc30a7	1848
Slc40a1	2579
Slc30a2	2617

REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING

REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING
	261
set	REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING
setSize	16
pANOVA	0.0691
s.dist	-0.263
p.adjustANOVA	0.258

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdpk1	-4591
Akt3	-4385
Pik3r3	-4154
Them4	-3763
Mtor	-3659
Map3k14	-3249
Pik3r1	-3095
Pik3ca	-3076
Akt1	-2769
Mapkap1	-2065
Akt2	487
Pik3r2	748
Cd28	1317
Rictor	3730
Fyn	4050
Mlst8	4405

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdpk1	-4591
Akt3	-4385
Pik3r3	-4154
Them4	-3763
Mtor	-3659
Map3k14	-3249
Pik3r1	-3095
Pik3ca	-3076
Akt1	-2769
Mapkap1	-2065
Akt2	487
Pik3r2	748
Cd28	1317
Rictor	3730
Fyn	4050
Mlst8	4405

REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C

REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
	410
set	REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
setSize	53
pANOVA	0.00102
s.dist	0.261
p.adjustANOVA	0.0249

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Ube2c	4268
Psmd13	4085
Psmd7	4049
Anapc4	3998
Ube2e1	3971
Psmd8	3928
Anapc1	3852
Rps27a	3650
Anapc5	3591
Psmb5	3295
Anapc2	3257
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Ube2c	4268
Psmd13	4085
Psmd7	4049
Anapc4	3998
Ube2e1	3971
Psmd8	3928
Anapc1	3852
Rps27a	3650
Anapc5	3591
Psmb5	3295
Anapc2	3257
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Psma3	1880
Psmc4	1703
Cdc23	1675
Psmd3	1399
Ube2d1	1133
Psmb7	1044
Psmd5	1034
Psmb1	894
Psmb2	810
Psmd2	612
Psmd9	522
Psmd10	399
Psmc2	372
Cdc16	-429
Anapc7	-447
Psma6	-788
Psma1	-955
Anapc10	-1647
Cdc27	-1670
Psmb10	-1714
Psmb4	-1742
Anapc11	-1946
Cdc26	-2581
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Psma7	-2870
Psma2	-3605
Psme1	-3960

REACTOME_PEPTIDE_CHAIN_ELONGATION

REACTOME_PEPTIDE_CHAIN_ELONGATION
	162
set	REACTOME_PEPTIDE_CHAIN_ELONGATION
setSize	66
pANOVA	0.00025
s.dist	0.261
p.adjustANOVA	0.011

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Rps14	4147
Rpl37a	4132
Rpl5	4025
Rps20	3957
Rplp1	3788
Rps26	3777
Rps4x	3772
Rps13	3736
Rps27a	3650
Rpl10a	3644
Rpl27a	3541
Rpsa	3247
Rps17	3105
Rps27	3043
Rpl18a	3026
Rps19	2955
Rplp2	2818
Rps15a	2524
Rpl14	2493

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579.0
Rps14	4147.0
Rpl37a	4132.0
Rpl5	4025.0
Rps20	3957.0
Rplp1	3788.0
Rps26	3777.0
Rps4x	3772.0
Rps13	3736.0
Rps27a	3650.0
Rpl10a	3644.0
Rpl27a	3541.0
Rpsa	3247.0
Rps17	3105.0
Rps27	3043.0
Rpl18a	3026.0
Rps19	2955.0
Rplp2	2818.0
Rps15a	2524.0
Rpl14	2493.0
Rps8	2357.0
Rpl19	1853.0
Rps29	1780.0
Rplp0	1712.0
Rpl4	1667.0
Rps9	1610.0
Rpl29	1605.0
Rpl8	1562.0
Rps25	1315.0
Rpl26	1314.0
Rps3a1	1161.0
Rps21	1095.0
Eef1a1	1074.0
Rpl11	1033.0
Rpl13	1022.0
Rps5	999.0
Rpl35	960.0
Rpl6	951.0
Rps23	833.0
Rpl30	769.0
Eef2	735.0
Rpl41	703.0
Rpl38	700.0
Rpl15	697.0
Rpl18	688.0
Rpl3	656.0
Rps3	572.0
Rps16	428.0
Rpl28	395.0
Rpl12	286.0
Rpl34	269.0
Rps24	198.0
Rps11	37.0
Rpl23	-64.0
Rpl32	-116.0
Rpl39	-926.0
Rpl36al	-986.0
Rpl23a	-1170.0
Rpl24	-1539.0
Rpl22	-1602.0
Rps6	-1615.0
Rpl3l	-2033.0
Rps7	-2050.0
Rps18	-2203.0
Rpl37	-3907.0
Rpl27-ps3	-4603.5

REACTOME_ORC1_REMOVAL_FROM_CHROMATIN

REACTOME_ORC1_REMOVAL_FROM_CHROMATIN
	46
set	REACTOME_ORC1_REMOVAL_FROM_CHROMATIN
setSize	51
pANOVA	0.00133
s.dist	0.26
p.adjustANOVA	0.0279

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Orc2	3164
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdkn1a	4587
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Psmd13	4085
Psmd7	4049
Psmd8	3928
Rps27a	3650
Psmb5	3295
Orc2	3164
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Cdkn1b	1928
Psma3	1880
Orc4	1758
Psmc4	1703
Mcm4	1477
Psmd3	1399
Mcm7	1270
Psmb7	1044
Psmd5	1034
Orc3	965
Psmb1	894
Psmb2	810
Psmd2	612
Psmd9	522
Psmd10	399
Psmc2	372
Mcm2	-719
Psma6	-788
Psma1	-955
Psmb10	-1714
Psmb4	-1742
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Psma7	-2870
Rb1	-2991
Psma2	-3605
Psme1	-3960
Orc5	-3984

REACTOME_PHOSPHORYLATION_OF_THE_APC_C

REACTOME_PHOSPHORYLATION_OF_THE_APC_C
	423
set	REACTOME_PHOSPHORYLATION_OF_THE_APC_C
setSize	14
pANOVA	0.0923
s.dist	0.26
p.adjustANOVA	0.297

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Anapc5	3591
Anapc2	3257
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ube2c	4268
Anapc4	3998
Ube2e1	3971
Anapc1	3852
Anapc5	3591
Anapc2	3257
Cdc23	1675
Ube2d1	1133
Cdc16	-429
Anapc7	-447
Anapc10	-1647
Cdc27	-1670
Anapc11	-1946
Cdc26	-2581

REACTOME_G2_M_CHECKPOINTS

REACTOME_G2_M_CHECKPOINTS
	449
set	REACTOME_G2_M_CHECKPOINTS
setSize	19
pANOVA	0.0524
s.dist	0.257
p.adjustANOVA	0.227

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdk2	4419
Atrip	4079
Rad1	3747
Rfc2	3392
Orc2	3164
Rpa2	2591
Rpa1	2227
Orc4	1758
Rad17	1659
Atm	1491
Mcm4	1477
Mcm7	1270
Atr	993
Orc3	965
Hus1	526
Mcm2	-719
Cdc25a	-1567
Orc5	-3984
Rfc4	-4638

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdk2	4419
Atrip	4079
Rad1	3747
Rfc2	3392
Orc2	3164
Rpa2	2591
Rpa1	2227
Orc4	1758
Rad17	1659
Atm	1491
Mcm4	1477
Mcm7	1270
Atr	993
Orc3	965
Hus1	526
Mcm2	-719
Cdc25a	-1567
Orc5	-3984
Rfc4	-4638

REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE

REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE
	294
set	REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE
setSize	61
pANOVA	0.00053
s.dist	0.257
p.adjustANOVA	0.0181

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Ube2c	4268
Psmd13	4085
Psmd7	4049
Cdc14a	4034
Anapc4	3998
Ube2e1	3971
Psmd8	3928
Anapc1	3852
Rps27a	3650
Anapc5	3591
Psmb5	3295
Anapc2	3257
Psmd1	3144
Psma4	2904
Psmd14	2804

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Uba52	4579
Psmf1	4511
Psmc3	4504
Psmc5	4433
Cdk2	4419
Ube2c	4268
Psmd13	4085
Psmd7	4049
Cdc14a	4034
Anapc4	3998
Ube2e1	3971
Psmd8	3928
Anapc1	3852
Rps27a	3650
Anapc5	3591
Psmb5	3295
Anapc2	3257
Psmd1	3144
Psma4	2904
Psmd14	2804
Psmb6	2786
Psmc1	2564
Psme4	2507
Bub3	2486
Psmd4	2427
Psmd12	2276
Psma5	2271
Psmd6	2193
Psma3	1880
Psmc4	1703
Cdc23	1675
Psmd3	1399
Ube2d1	1133
Psmb7	1044
Psmd5	1034
Psmb1	894
Psmb2	810
Psmd2	612
Psmd9	522
Psmd10	399
Cul1	387
Psmc2	372
Cdc16	-429
Anapc7	-447
Psma6	-788
Psma1	-955
Aurka	-1140
Btrc	-1379
Anapc10	-1647
Cdc27	-1670
Psmb10	-1714
Psmb4	-1742
Anapc11	-1946
Cdc26	-2581
Psmd11	-2582
Psmb3	-2692
Psmc6	-2706
Pttg1	-2847
Psma7	-2870
Psma2	-3605
Psme1	-3960

REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES
	359
set	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES
setSize	17
pANOVA	0.0678
s.dist	-0.256
p.adjustANOVA	0.256

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp2a2	-4686
Atp1a2	-4660
Atp1a1	-3453
Atp1b1	-3124
Atp2a3	-2218
Atp11b	-1924
Atp2b3	-1688
Atp11c	-1683
Atp7a	-1550
Atp2c1	-1544
Atp1b3	-747
Atp2a1	-311
Atp11a	-60
Atp1b2	685
Atp9a	1417
Atp8a1	1869
Atp9b	2886

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp2a2	-4686
Atp1a2	-4660
Atp1a1	-3453
Atp1b1	-3124
Atp2a3	-2218
Atp11b	-1924
Atp2b3	-1688
Atp11c	-1683
Atp7a	-1550
Atp2c1	-1544
Atp1b3	-747
Atp2a1	-311
Atp11a	-60
Atp1b2	685
Atp9a	1417
Atp8a1	1869
Atp9b	2886

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports