date generated: 2025-02-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
stat
0610009B22Rik -0.6838268
0610009L18Rik 0.5652733
0610010K14Rik 0.6642443
0610012G03Rik -0.1850531
0610030E20Rik -0.3888428
0610040J01Rik 0.0455598

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 674
num_genes_in_profile 9539
duplicated_genes_present 0
num_profile_genes_in_sets 2809
num_profile_genes_not_in_sets 6730

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 674
num_genesets_excluded 209
num_genesets_included 465

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 0.000419 0.614 0.0974
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 0.000829 0.557 0.1250
REACTOME COMPLEMENT CASCADE 11 0.004010 -0.501 0.1390
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS 11 0.004470 -0.495 0.1390
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 17 0.002650 -0.421 0.1370
REACTOME PLATELET AGGREGATION PLUG FORMATION 18 0.002290 -0.415 0.1330
REACTOME SIGNAL ATTENUATION 10 0.024000 -0.412 0.3920
REACTOME SPRY REGULATION OF FGF SIGNALING 12 0.015500 -0.404 0.3140
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 0.002950 0.394 0.1370
REACTOME GPVI MEDIATED ACTIVATION CASCADE 16 0.007680 -0.385 0.1880
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 10 0.036600 -0.382 0.4610
REACTOME GLUCONEOGENESIS 21 0.003250 0.371 0.1370
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 13 0.026900 0.355 0.4040
REACTOME METABOLISM OF POLYAMINES 11 0.046400 0.347 0.4760
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 0.048100 0.344 0.4760
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 22 0.006840 -0.333 0.1810
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 0.010400 0.331 0.2410
REACTOME GLUTATHIONE CONJUGATION 12 0.047400 0.331 0.4760
REACTOME CTLA4 INHIBITORY SIGNALING 15 0.031700 -0.320 0.4470
REACTOME DOUBLE STRAND BREAK REPAIR 12 0.067500 0.305 0.5270
REACTOME REGULATION OF SIGNALING BY CBL 13 0.058100 -0.304 0.4760
REACTOME RNA POL I TRANSCRIPTION TERMINATION 19 0.024800 0.298 0.3920
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 0.064700 0.296 0.5190
REACTOME ION CHANNEL TRANSPORT 18 0.032800 -0.291 0.4480
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 17 0.039700 -0.288 0.4610
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 16 0.049700 0.283 0.4760
REACTOME TRNA AMINOACYLATION 39 0.002250 0.283 0.1330
REACTOME METABOLISM OF PORPHYRINS 11 0.105000 0.282 0.6500
REACTOME GLUCOSE METABOLISM 46 0.001070 0.279 0.1250
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 0.024500 0.277 0.3920
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 13 0.084800 0.276 0.5970
REACTOME ION TRANSPORT BY P TYPE ATPASES 17 0.051000 -0.274 0.4760
REACTOME FATTY ACYL COA BIOSYNTHESIS 12 0.101000 -0.273 0.6450
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 11 0.117000 -0.273 0.7000
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 43 0.002210 -0.270 0.1330
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 14 0.091000 0.261 0.6050
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 19 0.049700 0.260 0.4760
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 21 0.039300 -0.260 0.4610
REACTOME TIE2 SIGNALING 13 0.107000 -0.258 0.6500
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 11 0.139000 -0.257 0.7610
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 11 0.143000 -0.255 0.7610
REACTOME PROLONGED ERK ACTIVATION EVENTS 16 0.079200 -0.254 0.5660
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 0.006990 0.253 0.1810
REACTOME GLYCOLYSIS 19 0.056300 0.253 0.4760
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 44 0.004090 -0.250 0.1390
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 15 0.094700 0.249 0.6110
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 10 0.190000 -0.240 0.7820
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 11 0.173000 -0.237 0.7810
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 22 0.054700 0.237 0.4760
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 34 0.017900 -0.235 0.3190


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 0.000419 0.614000 0.0974
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 0.000829 0.557000 0.1250
REACTOME COMPLEMENT CASCADE 11 0.004010 -0.501000 0.1390
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS 11 0.004470 -0.495000 0.1390
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 17 0.002650 -0.421000 0.1370
REACTOME PLATELET AGGREGATION PLUG FORMATION 18 0.002290 -0.415000 0.1330
REACTOME SIGNAL ATTENUATION 10 0.024000 -0.412000 0.3920
REACTOME SPRY REGULATION OF FGF SIGNALING 12 0.015500 -0.404000 0.3140
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 0.002950 0.394000 0.1370
REACTOME GPVI MEDIATED ACTIVATION CASCADE 16 0.007680 -0.385000 0.1880
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 10 0.036600 -0.382000 0.4610
REACTOME GLUCONEOGENESIS 21 0.003250 0.371000 0.1370
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 13 0.026900 0.355000 0.4040
REACTOME METABOLISM OF POLYAMINES 11 0.046400 0.347000 0.4760
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 0.048100 0.344000 0.4760
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 22 0.006840 -0.333000 0.1810
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 0.010400 0.331000 0.2410
REACTOME GLUTATHIONE CONJUGATION 12 0.047400 0.331000 0.4760
REACTOME CTLA4 INHIBITORY SIGNALING 15 0.031700 -0.320000 0.4470
REACTOME DOUBLE STRAND BREAK REPAIR 12 0.067500 0.305000 0.5270
REACTOME REGULATION OF SIGNALING BY CBL 13 0.058100 -0.304000 0.4760
REACTOME RNA POL I TRANSCRIPTION TERMINATION 19 0.024800 0.298000 0.3920
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 0.064700 0.296000 0.5190
REACTOME ION CHANNEL TRANSPORT 18 0.032800 -0.291000 0.4480
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 17 0.039700 -0.288000 0.4610
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 16 0.049700 0.283000 0.4760
REACTOME TRNA AMINOACYLATION 39 0.002250 0.283000 0.1330
REACTOME METABOLISM OF PORPHYRINS 11 0.105000 0.282000 0.6500
REACTOME GLUCOSE METABOLISM 46 0.001070 0.279000 0.1250
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 0.024500 0.277000 0.3920
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 13 0.084800 0.276000 0.5970
REACTOME ION TRANSPORT BY P TYPE ATPASES 17 0.051000 -0.274000 0.4760
REACTOME FATTY ACYL COA BIOSYNTHESIS 12 0.101000 -0.273000 0.6450
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 11 0.117000 -0.273000 0.7000
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 43 0.002210 -0.270000 0.1330
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 14 0.091000 0.261000 0.6050
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 19 0.049700 0.260000 0.4760
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 21 0.039300 -0.260000 0.4610
REACTOME TIE2 SIGNALING 13 0.107000 -0.258000 0.6500
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 11 0.139000 -0.257000 0.7610
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 11 0.143000 -0.255000 0.7610
REACTOME PROLONGED ERK ACTIVATION EVENTS 16 0.079200 -0.254000 0.5660
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 0.006990 0.253000 0.1810
REACTOME GLYCOLYSIS 19 0.056300 0.253000 0.4760
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 44 0.004090 -0.250000 0.1390
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 15 0.094700 0.249000 0.6110
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 10 0.190000 -0.240000 0.7820
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 11 0.173000 -0.237000 0.7810
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 22 0.054700 0.237000 0.4760
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 34 0.017900 -0.235000 0.3190
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 10 0.201000 -0.233000 0.7880
REACTOME ERKS ARE INACTIVATED 10 0.202000 -0.233000 0.7880
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 18 0.091300 0.230000 0.6050
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 26 0.043100 -0.229000 0.4760
REACTOME MICRORNA MIRNA BIOGENESIS 18 0.092300 0.229000 0.6050
REACTOME CHOLESTEROL BIOSYNTHESIS 12 0.174000 -0.227000 0.7810
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 29 0.035800 0.225000 0.4610
REACTOME ENOS ACTIVATION AND REGULATION 12 0.180000 -0.224000 0.7810
REACTOME PURINE METABOLISM 27 0.046700 0.221000 0.4760
REACTOME RAP1 SIGNALLING 12 0.192000 -0.218000 0.7820
REACTOME EXTENSION OF TELOMERES 14 0.164000 0.215000 0.7810
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 14 0.169000 -0.213000 0.7810
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 43 0.016800 0.211000 0.3140
REACTOME DEADENYLATION OF MRNA 16 0.146000 0.210000 0.7610
REACTOME GLOBAL GENOMIC NER GG NER 24 0.078600 0.208000 0.5660
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 107 0.000229 0.207000 0.0974
REACTOME G PROTEIN BETA GAMMA SIGNALLING 12 0.219000 -0.205000 0.8160
REACTOME RNA POL I TRANSCRIPTION INITIATION 23 0.091100 0.204000 0.6050
REACTOME COLLAGEN FORMATION 29 0.058400 -0.203000 0.4760
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 60 0.006730 -0.203000 0.1810
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 0.207000 -0.202000 0.7990
REACTOME G ALPHA Z SIGNALLING EVENTS 20 0.119000 0.201000 0.7010
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 15 0.181000 -0.200000 0.7810
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 14 0.201000 -0.197000 0.7880
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 17 0.160000 -0.197000 0.7810
REACTOME MITOTIC G2 G2 M PHASES 50 0.016400 0.196000 0.3140
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 73 0.004470 0.193000 0.1390
REACTOME SMOOTH MUSCLE CONTRACTION 19 0.149000 0.191000 0.7610
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 15 0.208000 0.188000 0.7990
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 23 0.124000 -0.185000 0.7030
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 19 0.162000 0.185000 0.7810
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 14 0.234000 -0.184000 0.8340
REACTOME BOTULINUM NEUROTOXICITY 10 0.315000 -0.183000 0.8880
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS 10 0.315000 -0.183000 0.8880
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 20 0.159000 0.182000 0.7810
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 107 0.001360 -0.180000 0.1260
REACTOME REGULATORY RNA PATHWAYS 21 0.156000 0.179000 0.7780
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 38 0.057600 0.178000 0.4760
REACTOME GPCR LIGAND BINDING 46 0.039100 -0.176000 0.4610
REACTOME COSTIMULATION BY THE CD28 FAMILY 34 0.077300 -0.175000 0.5660
REACTOME DAG AND IP3 SIGNALING 15 0.241000 0.175000 0.8360
REACTOME ARMS MEDIATED ACTIVATION 14 0.261000 -0.174000 0.8750
REACTOME MEIOTIC SYNAPSIS 17 0.219000 -0.172000 0.8160
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 15 0.251000 0.171000 0.8580
REACTOME LIPOPROTEIN METABOLISM 11 0.327000 -0.171000 0.8880
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 11 0.334000 -0.168000 0.8880
REACTOME G1 PHASE 25 0.148000 -0.167000 0.7610
REACTOME EFFECTS OF PIP2 HYDROLYSIS 13 0.297000 0.167000 0.8830
REACTOME CELL JUNCTION ORGANIZATION 28 0.127000 -0.167000 0.7110
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 17 0.234000 -0.167000 0.8340
REACTOME CELL CELL COMMUNICATION 52 0.038500 -0.166000 0.4610
REACTOME ACTIVATED TLR4 SIGNALLING 61 0.025300 -0.166000 0.3920
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 27 0.140000 -0.164000 0.7610
REACTOME RNA POL I TRANSCRIPTION 26 0.148000 0.164000 0.7610
REACTOME SYNTHESIS OF PA 10 0.370000 0.164000 0.8880
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 15 0.273000 0.164000 0.8750
REACTOME NETRIN1 SIGNALING 21 0.195000 -0.163000 0.7880
REACTOME TOLL RECEPTOR CASCADES 74 0.016900 -0.161000 0.3140
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 11 0.357000 -0.160000 0.8880
REACTOME ADP SIGNALLING THROUGH P2RY1 11 0.361000 -0.159000 0.8880
REACTOME PHASE II CONJUGATION 23 0.191000 0.158000 0.7820
REACTOME SIGNALING BY NOTCH3 10 0.388000 -0.158000 0.8880
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 13 0.330000 -0.156000 0.8880
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 10 0.393000 -0.156000 0.8880
REACTOME TRIF MEDIATED TLR3 SIGNALING 53 0.051200 -0.155000 0.4760
REACTOME CD28 CO STIMULATION 22 0.211000 -0.154000 0.8050
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 15 0.303000 -0.154000 0.8860
REACTOME PYRUVATE METABOLISM 16 0.288000 0.153000 0.8750
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 56 0.047600 -0.153000 0.4760
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 10 0.405000 0.152000 0.8880
REACTOME SIGNAL AMPLIFICATION 14 0.327000 -0.151000 0.8880
REACTOME SIGNALLING TO ERKS 28 0.166000 -0.151000 0.7810
REACTOME PURINE SALVAGE 10 0.417000 0.148000 0.8880
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 58 0.052700 -0.147000 0.4760
REACTOME BASIGIN INTERACTIONS 13 0.358000 -0.147000 0.8880
REACTOME SIGNALING BY NOTCH2 10 0.422000 -0.147000 0.8880
REACTOME NCAM1 INTERACTIONS 18 0.282000 -0.146000 0.8750
REACTOME TCR SIGNALING 28 0.181000 -0.146000 0.7810
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 52 0.069200 -0.146000 0.5280
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 17 0.298000 0.146000 0.8830
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 13 0.370000 -0.144000 0.8880
REACTOME NUCLEOTIDE EXCISION REPAIR 39 0.121000 0.144000 0.7030
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 47 0.091600 -0.142000 0.6050
REACTOME CA DEPENDENT EVENTS 13 0.378000 0.141000 0.8880
REACTOME VIRAL MESSENGER RNA SYNTHESIS 14 0.365000 0.140000 0.8880
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 10 0.449000 -0.138000 0.8880
REACTOME G ALPHA S SIGNALLING EVENTS 27 0.215000 0.138000 0.8120
REACTOME AQUAPORIN MEDIATED TRANSPORT 20 0.288000 0.137000 0.8750
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 20 0.288000 0.137000 0.8750
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 21 0.278000 -0.137000 0.8750
REACTOME METAL ION SLC TRANSPORTERS 12 0.417000 -0.135000 0.8880
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 33 0.179000 -0.135000 0.7810
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS 16 0.356000 -0.133000 0.8880
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 34 0.179000 0.133000 0.7810
REACTOME EGFR DOWNREGULATION 23 0.269000 -0.133000 0.8750
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 21 0.291000 0.133000 0.8750
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 0.448000 0.132000 0.8880
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 17 0.351000 0.131000 0.8880
REACTOME INNATE IMMUNE SYSTEM 121 0.013300 -0.131000 0.2960
REACTOME MITOCHONDRIAL PROTEIN IMPORT 42 0.143000 0.131000 0.7610
REACTOME TRIGLYCERIDE BIOSYNTHESIS 22 0.289000 -0.131000 0.8750
REACTOME PEPTIDE CHAIN ELONGATION 67 0.068000 -0.129000 0.5270
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 19 0.331000 0.129000 0.8880
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 28 0.239000 0.129000 0.8360
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 14 0.405000 0.129000 0.8880
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 14 0.407000 -0.128000 0.8880
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 18 0.357000 0.125000 0.8880
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 16 0.387000 -0.125000 0.8880
REACTOME PHOSPHORYLATION OF THE APC C 14 0.423000 0.124000 0.8880
REACTOME LAGGING STRAND SYNTHESIS 10 0.499000 0.123000 0.9080
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 38 0.188000 0.123000 0.7820
REACTOME DNA REPAIR 69 0.078400 0.123000 0.5660
REACTOME MRNA SPLICING MINOR PATHWAY 39 0.186000 0.123000 0.7820
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 22 0.320000 0.122000 0.8880
REACTOME RESPIRATORY ELECTRON TRANSPORT 59 0.104000 0.122000 0.6500
REACTOME IL RECEPTOR SHC SIGNALING 15 0.414000 0.122000 0.8880
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 42 0.175000 -0.121000 0.7810
REACTOME RNA POL III CHAIN ELONGATION 16 0.413000 0.118000 0.8880
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 10 0.520000 -0.117000 0.9090
REACTOME PLC BETA MEDIATED EVENTS 19 0.386000 0.115000 0.8880
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 10 0.533000 0.114000 0.9150
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 18 0.405000 -0.113000 0.8880
REACTOME SIGNALING BY FGFR MUTANTS 26 0.318000 -0.113000 0.8880
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 10 0.537000 -0.113000 0.9150
REACTOME APOPTOTIC EXECUTION PHASE 28 0.303000 0.113000 0.8860
REACTOME MUSCLE CONTRACTION 37 0.237000 0.113000 0.8340
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX 28 0.310000 0.111000 0.8880
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 17 0.429000 -0.111000 0.8880
REACTOME G ALPHA I SIGNALLING EVENTS 31 0.288000 -0.110000 0.8750
REACTOME SIGNALING BY SCF KIT 56 0.156000 -0.110000 0.7780
REACTOME TRANSCRIPTION COUPLED NER TC NER 35 0.263000 0.109000 0.8750
REACTOME NEPHRIN INTERACTIONS 14 0.479000 -0.109000 0.9020
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT 19 0.412000 0.109000 0.8880
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 107 0.054500 0.108000 0.4760
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 17 0.444000 0.107000 0.8880
REACTOME KERATAN SULFATE BIOSYNTHESIS 12 0.523000 -0.107000 0.9090
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 14 0.495000 0.105000 0.9080
REACTOME P38MAPK EVENTS 10 0.569000 0.104000 0.9220
REACTOME PRE NOTCH PROCESSING IN GOLGI 14 0.504000 -0.103000 0.9080
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 15 0.489000 -0.103000 0.9080
REACTOME ERK MAPK TARGETS 18 0.449000 -0.103000 0.8880
REACTOME METABOLISM OF VITAMINS AND COFACTORS 35 0.292000 -0.103000 0.8750
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 17 0.463000 -0.103000 0.8960
REACTOME MEIOSIS 27 0.366000 -0.101000 0.8880
REACTOME DESTABILIZATION OF MRNA BY KSRP 14 0.515000 0.100000 0.9080
REACTOME O LINKED GLYCOSYLATION OF MUCINS 11 0.565000 0.100000 0.9220
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 20 0.439000 -0.100000 0.8880
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 11 0.567000 -0.099700 0.9220
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 18 0.466000 -0.099400 0.8960
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 89 0.108000 -0.098900 0.6500
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 57 0.198000 -0.098700 0.7880
REACTOME RNA POL III TRANSCRIPTION TERMINATION 18 0.470000 0.098400 0.8960
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 16 0.496000 0.098300 0.9080
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 11 0.577000 -0.097000 0.9290
REACTOME NUCLEAR SIGNALING BY ERBB4 21 0.442000 0.096900 0.8880
REACTOME PEROXISOMAL LIPID METABOLISM 16 0.506000 -0.096100 0.9080
REACTOME POTASSIUM CHANNELS 21 0.449000 0.095400 0.8880
REACTOME INSULIN RECEPTOR RECYCLING 15 0.525000 -0.094900 0.9090
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 54 0.229000 0.094800 0.8340
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 16 0.516000 0.093900 0.9080
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 23 0.437000 0.093700 0.8880
REACTOME DOWNSTREAM TCR SIGNALING 20 0.470000 -0.093500 0.8960
REACTOME IRON UPTAKE AND TRANSPORT 23 0.442000 -0.092800 0.8880
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 13 0.566000 -0.092100 0.9220
REACTOME BIOLOGICAL OXIDATIONS 38 0.328000 0.091800 0.8880
REACTOME SIGNALING BY BMP 17 0.514000 0.091600 0.9080
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 11 0.600000 0.091400 0.9360
REACTOME ELONGATION ARREST AND RECOVERY 24 0.444000 0.090400 0.8880
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 37 0.343000 -0.090200 0.8880
REACTOME IL 3 5 AND GM CSF SIGNALING 24 0.445000 -0.090200 0.8880
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 35 0.371000 0.087500 0.8880
REACTOME IL 2 SIGNALING 25 0.451000 0.087200 0.8880
REACTOME MRNA CAPPING 28 0.427000 0.086800 0.8880
REACTOME HEMOSTASIS 214 0.031200 -0.086000 0.4470
REACTOME CIRCADIAN CLOCK 43 0.331000 0.085800 0.8880
REACTOME MTORC1 MEDIATED SIGNALLING 11 0.623000 0.085600 0.9420
REACTOME SIGNALING BY RHO GTPASES 66 0.234000 -0.084900 0.8340
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 85 0.179000 -0.084400 0.7810
REACTOME SIGNALING BY NOTCH4 10 0.644000 -0.084300 0.9440
REACTOME SULFUR AMINO ACID METABOLISM 19 0.529000 0.083500 0.9100
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 0.590000 0.083300 0.9290
REACTOME REGULATION OF INSULIN SECRETION 36 0.388000 -0.083200 0.8880
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 37 0.387000 -0.082200 0.8880
REACTOME SIGNAL TRANSDUCTION BY L1 28 0.456000 -0.081500 0.8950
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 13 0.617000 0.080200 0.9420
REACTOME METABOLISM OF NON CODING RNA 42 0.372000 -0.079700 0.8880
REACTOME RNA POL III TRANSCRIPTION 31 0.448000 -0.078700 0.8880
REACTOME SOS MEDIATED SIGNALLING 13 0.625000 -0.078200 0.9420
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 21 0.546000 -0.076200 0.9190
REACTOME PYRIMIDINE METABOLISM 10 0.680000 -0.075400 0.9580
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 57 0.332000 0.074400 0.8880
REACTOME KERATAN SULFATE KERATIN METABOLISM 15 0.619000 -0.074300 0.9420
REACTOME PERK REGULATED GENE EXPRESSION 22 0.549000 -0.073900 0.9210
REACTOME G ALPHA Q SIGNALLING EVENTS 40 0.423000 -0.073400 0.8880
REACTOME TELOMERE MAINTENANCE 19 0.580000 0.073400 0.9290
REACTOME INSULIN SYNTHESIS AND PROCESSING 13 0.649000 -0.072900 0.9440
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX 27 0.513000 0.072800 0.9080
REACTOME HS GAG BIOSYNTHESIS 16 0.616000 0.072500 0.9420
REACTOME PI METABOLISM 38 0.444000 0.071900 0.8880
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 83 0.261000 -0.071600 0.8750
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING 20 0.582000 -0.071200 0.9290
REACTOME PLATELET SENSITIZATION BY LDL 11 0.685000 -0.070700 0.9580
REACTOME SIGNALING BY ERBB2 67 0.329000 0.069200 0.8880
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 99 0.236000 0.069100 0.8340
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 60 0.358000 0.068700 0.8880
REACTOME SIGNALING BY ERBB4 66 0.345000 0.067400 0.8880
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 11 0.699000 0.067200 0.9680
REACTOME INTERFERON GAMMA SIGNALING 25 0.562000 0.067100 0.9220
REACTOME METABOLISM OF NUCLEOTIDES 49 0.423000 0.066200 0.8880
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 14 0.670000 -0.065800 0.9560
REACTOME METABOLISM OF CARBOHYDRATES 136 0.191000 0.065200 0.7820
REACTOME PROTEIN FOLDING 40 0.478000 0.064900 0.9020
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 58 0.396000 -0.064500 0.8880
REACTOME GLYCOSAMINOGLYCAN METABOLISM 52 0.427000 -0.063800 0.8880
REACTOME HIV LIFE CYCLE 94 0.288000 0.063600 0.8750
REACTOME SIGNALING BY NOTCH 77 0.341000 -0.062900 0.8880
REACTOME SIGNALING BY NODAL 11 0.720000 0.062400 0.9720
REACTOME SIGNALING BY FGFR1 MUTANTS 20 0.631000 -0.062000 0.9440
REACTOME GPCR DOWNSTREAM SIGNALING 108 0.272000 -0.061400 0.8750
REACTOME G0 AND EARLY G1 11 0.725000 0.061300 0.9720
REACTOME REGULATION OF MITOTIC CELL CYCLE 61 0.412000 0.060800 0.8880
REACTOME NOD1 2 SIGNALING PATHWAY 18 0.660000 0.059900 0.9440
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 47 0.479000 0.059700 0.9020
REACTOME IL1 SIGNALING 24 0.614000 0.059600 0.9420
REACTOME SIGNALING BY PDGF 87 0.348000 -0.058400 0.8880
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 49 0.482000 0.058200 0.9030
REACTOME DEVELOPMENTAL BIOLOGY 243 0.123000 -0.057900 0.7030
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 43 0.513000 0.057800 0.9080
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 23 0.635000 -0.057300 0.9440
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 38 0.544000 0.056900 0.9190
REACTOME REGULATION OF APOPTOSIS 49 0.493000 0.056700 0.9080
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 23 0.641000 -0.056200 0.9440
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 15 0.706000 -0.056200 0.9680
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 12 0.739000 -0.055500 0.9850
REACTOME TRANSLATION 124 0.288000 -0.055500 0.8750
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 43 0.535000 0.054700 0.9150
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 166 0.227000 0.054700 0.8340
REACTOME SIGNALING BY GPCR 151 0.250000 -0.054500 0.8580
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 28 0.622000 0.054000 0.9420
REACTOME MHC CLASS II ANTIGEN PRESENTATION 61 0.469000 0.053800 0.8960
REACTOME LATE PHASE OF HIV LIFE CYCLE 85 0.404000 0.052500 0.8880
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 16 0.720000 -0.051800 0.9720
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 22 0.678000 -0.051200 0.9580
REACTOME CELL CELL JUNCTION ORGANIZATION 14 0.741000 -0.051000 0.9850
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 42 0.568000 0.051000 0.9220
REACTOME HIV INFECTION 158 0.271000 0.051000 0.8750
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 57 0.507000 0.050900 0.9080
REACTOME MRNA SPLICING 100 0.384000 0.050500 0.8880
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 18 0.718000 0.049200 0.9720
REACTOME GLUCOSE TRANSPORT 29 0.648000 -0.049100 0.9440
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 36 0.618000 0.048100 0.9420
REACTOME PIP3 ACTIVATES AKT SIGNALING 25 0.678000 0.048000 0.9580
REACTOME SIGNALLING TO RAS 20 0.710000 0.048000 0.9680
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 38 0.611000 0.047800 0.9420
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 11 0.787000 -0.047000 0.9920
REACTOME PLATELET HOMEOSTASIS 32 0.651000 0.046300 0.9440
REACTOME MITOTIC G1 G1 S PHASES 84 0.467000 -0.046100 0.8960
REACTOME GABA B RECEPTOR ACTIVATION 13 0.774000 0.045900 0.9920
REACTOME PKB MEDIATED EVENTS 27 0.681000 0.045800 0.9580
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 44 0.600000 0.045800 0.9360
REACTOME G1 S TRANSITION 69 0.520000 -0.044800 0.9090
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 43 0.614000 0.044500 0.9420
REACTOME INTEGRATION OF ENERGY METABOLISM 58 0.561000 -0.044200 0.9220
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 12 0.794000 -0.043600 0.9920
REACTOME CELL CYCLE CHECKPOINTS 80 0.505000 0.043300 0.9080
REACTOME CELL CYCLE 217 0.278000 0.043000 0.8750
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 54 0.587000 0.042800 0.9290
REACTOME INFLUENZA LIFE CYCLE 114 0.434000 -0.042500 0.8880
REACTOME CELL CYCLE MITOTIC 190 0.316000 0.042400 0.8880
REACTOME MRNA PROCESSING 141 0.408000 0.040500 0.8880
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 126 0.440000 0.040000 0.8880
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 32 0.699000 0.039500 0.9680
REACTOME INWARDLY RECTIFYING K CHANNELS 10 0.830000 -0.039200 0.9920
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 32 0.705000 -0.038700 0.9680
REACTOME G ALPHA1213 SIGNALLING EVENTS 44 0.659000 -0.038600 0.9440
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 54 0.627000 -0.038200 0.9420
REACTOME INTERFERON SIGNALING 81 0.555000 0.038100 0.9220
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 52 0.639000 -0.037600 0.9440
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 48 0.655000 0.037300 0.9440
REACTOME DIABETES PATHWAYS 91 0.540000 -0.037300 0.9160
REACTOME DARPP 32 EVENTS 17 0.791000 0.037100 0.9920
REACTOME SIGNALING BY INSULIN RECEPTOR 73 0.586000 -0.036900 0.9290
REACTOME MRNA 3 END PROCESSING 31 0.722000 0.036900 0.9720
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 11 0.833000 0.036800 0.9920
REACTOME SIGNALING BY HIPPO 15 0.805000 0.036700 0.9920
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 101 0.526000 -0.036600 0.9090
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 16 0.803000 -0.036000 0.9920
REACTOME SEMAPHORIN INTERACTIONS 43 0.686000 -0.035700 0.9580
REACTOME GLYCOSPHINGOLIPID METABOLISM 21 0.778000 0.035600 0.9920
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 86 0.571000 -0.035400 0.9230
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 25 0.761000 -0.035200 0.9920
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 23 0.773000 -0.034800 0.9920
REACTOME SHC MEDIATED SIGNALLING 13 0.829000 -0.034700 0.9920
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 29 0.748000 -0.034500 0.9910
REACTOME SIGNALLING BY NGF 154 0.463000 -0.034400 0.8960
REACTOME HOST INTERACTIONS OF HIV FACTORS 99 0.563000 0.033800 0.9220
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 41 0.710000 0.033700 0.9680
REACTOME DESTABILIZATION OF MRNA BY BRF1 16 0.817000 0.033400 0.9920
REACTOME CHROMOSOME MAINTENANCE 37 0.727000 0.033200 0.9720
REACTOME SIGNALING BY ROBO RECEPTOR 20 0.798000 0.033000 0.9920
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 191 0.442000 0.032400 0.8880
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN 18 0.816000 -0.031800 0.9920
REACTOME MEMBRANE TRAFFICKING 94 0.596000 0.031700 0.9360
REACTOME PPARA ACTIVATES GENE EXPRESSION 81 0.628000 -0.031200 0.9420
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 73 0.652000 0.030600 0.9440
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY 11 0.861000 0.030500 0.9920
REACTOME ACTIVATION OF GENES BY ATF4 19 0.819000 -0.030400 0.9920
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 52 0.710000 -0.029900 0.9680
REACTOME RNA POL II TRANSCRIPTION 86 0.635000 0.029700 0.9440
REACTOME PHOSPHOLIPID METABOLISM 116 0.585000 0.029500 0.9290
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 175 0.510000 0.029000 0.9080
REACTOME METABOLISM OF RNA 217 0.483000 -0.027800 0.9030
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 17 0.843000 -0.027700 0.9920
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 0.880000 -0.027500 0.9920
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 37 0.777000 0.027000 0.9920
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS 16 0.853000 -0.026800 0.9920
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 21 0.832000 0.026800 0.9920
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 25 0.817000 0.026800 0.9920
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 21 0.835000 -0.026300 0.9920
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 97 0.658000 -0.026100 0.9440
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 28 0.811000 0.026100 0.9920
REACTOME SHC MEDIATED CASCADE 10 0.889000 -0.025600 0.9920
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 48 0.760000 0.025500 0.9920
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA 20 0.851000 0.024300 0.9920
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 18 0.859000 0.024200 0.9920
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 18 0.859000 0.024200 0.9920
REACTOME MITOTIC PROMETAPHASE 44 0.795000 -0.022600 0.9920
REACTOME SYNTHESIS OF DNA 61 0.761000 0.022600 0.9920
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 46 0.800000 0.021700 0.9920
REACTOME AXON GUIDANCE 146 0.654000 -0.021600 0.9440
REACTOME MYOGENESIS 21 0.865000 -0.021400 0.9920
REACTOME SIGNALING BY ILS 62 0.772000 -0.021300 0.9920
REACTOME PI3K AKT ACTIVATION 31 0.838000 -0.021200 0.9920
REACTOME MEIOTIC RECOMBINATION 10 0.908000 0.021100 0.9920
REACTOME ER PHAGOSOME PATHWAY 49 0.802000 -0.020700 0.9920
REACTOME SIGNALING BY WNT 57 0.788000 -0.020600 0.9920
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 103 0.726000 -0.020100 0.9720
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 51 0.816000 0.018900 0.9920
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS 24 0.874000 0.018700 0.9920
REACTOME G2 M CHECKPOINTS 18 0.896000 -0.017900 0.9920
REACTOME HS GAG DEGRADATION 13 0.912000 0.017700 0.9920
REACTOME LYSOSOME VESICLE BIOGENESIS 17 0.903000 0.017100 0.9920
REACTOME METABOLISM OF MRNA 178 0.704000 -0.016600 0.9680
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 59 0.829000 -0.016300 0.9920
REACTOME NEURONAL SYSTEM 90 0.791000 0.016200 0.9920
REACTOME DNA STRAND ELONGATION 13 0.920000 -0.016200 0.9920
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA 13 0.923000 0.015600 0.9920
REACTOME SIGNALING BY NOTCH1 53 0.846000 -0.015400 0.9920
REACTOME IMMUNE SYSTEM 520 0.555000 -0.015400 0.9220
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 12 0.928000 0.015100 0.9920
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 19 0.910000 -0.014900 0.9920
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 43 0.869000 0.014600 0.9920
REACTOME CALNEXIN CALRETICULIN CYCLE 11 0.934000 0.014400 0.9920
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 282 0.682000 -0.014300 0.9580
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 44 0.871000 0.014200 0.9920
REACTOME RECYCLING PATHWAY OF L1 19 0.915000 -0.014100 0.9920
REACTOME PROCESSING OF INTRONLESS PRE MRNAS 13 0.930000 -0.014100 0.9920
REACTOME G PROTEIN ACTIVATION 10 0.939000 0.014000 0.9920
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 128 0.785000 0.014000 0.9920
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 46 0.872000 0.013800 0.9920
REACTOME BASE EXCISION REPAIR 13 0.932000 0.013800 0.9920
REACTOME PI 3K CASCADE 34 0.890000 -0.013700 0.9920
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 24 0.909000 0.013500 0.9920
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 22 0.915000 0.013200 0.9920
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 56 0.867000 0.013000 0.9920
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 29 0.904000 -0.012900 0.9920
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 41 0.887000 0.012900 0.9920
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 50 0.876000 0.012800 0.9920
REACTOME UNFOLDED PROTEIN RESPONSE 65 0.862000 0.012500 0.9920
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 13 0.938000 0.012400 0.9920
REACTOME SIGNALING BY FGFR 69 0.861000 0.012200 0.9920
REACTOME OPIOID SIGNALLING 38 0.897000 0.012100 0.9920
REACTOME STRIATED MUSCLE CONTRACTION 22 0.922000 0.012100 0.9920
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 18 0.930000 -0.012000 0.9920
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 70 0.871000 0.011200 0.9920
REACTOME INTERFERON ALPHA BETA SIGNALING 17 0.937000 0.011100 0.9920
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 16 0.940000 -0.010900 0.9920
REACTOME ORC1 REMOVAL FROM CHROMATIN 50 0.894000 0.010900 0.9920
REACTOME SHC RELATED EVENTS 14 0.945000 -0.010700 0.9920
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM 10 0.955000 -0.010300 0.9930
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 40 0.912000 -0.010100 0.9920
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 15 0.948000 -0.009660 0.9920
REACTOME TRAFFICKING OF AMPA RECEPTORS 16 0.951000 0.008870 0.9920
REACTOME SPHINGOLIPID METABOLISM 37 0.928000 0.008620 0.9920
REACTOME SIGNALING BY FGFR IN DISEASE 81 0.894000 0.008560 0.9920
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 42 0.925000 0.008360 0.9920
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 66 0.913000 -0.007800 0.9920
REACTOME GAB1 SIGNALOSOME 32 0.941000 -0.007610 0.9920
REACTOME MITOTIC M M G1 PHASES 97 0.901000 -0.007360 0.9920
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 10 0.970000 0.006880 0.9950
REACTOME PI3K CASCADE 45 0.938000 0.006670 0.9920
REACTOME APOPTOSIS 97 0.923000 0.005720 0.9920
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 49 0.945000 -0.005680 0.9920
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 145 0.919000 -0.004930 0.9920
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 14 0.976000 0.004590 0.9950
REACTOME M G1 TRANSITION 52 0.956000 0.004400 0.9930
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 64 0.952000 0.004380 0.9920
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 52 0.960000 -0.004010 0.9940
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 44 0.964000 -0.003950 0.9950
REACTOME METABOLISM OF PROTEINS 306 0.915000 -0.003570 0.9920
REACTOME L1CAM INTERACTIONS 51 0.965000 0.003540 0.9950
REACTOME TRANSCRIPTION 127 0.946000 0.003480 0.9920
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 23 0.983000 0.002610 0.9950
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 82 0.969000 -0.002520 0.9950
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 17 0.986000 0.002480 0.9950
REACTOME ADAPTIVE IMMUNE SYSTEM 340 0.951000 -0.001980 0.9920
REACTOME FRS2 MEDIATED CASCADE 17 0.990000 0.001680 0.9950
REACTOME S PHASE 72 0.985000 0.001300 0.9950
REACTOME GABA RECEPTOR ACTIVATION 14 0.995000 0.001020 0.9950
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 53 0.991000 -0.000865 0.9950
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 24 0.994000 -0.000841 0.9950
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 21 0.995000 0.000780 0.9950
REACTOME GENERIC TRANSCRIPTION PATHWAY 141 0.988000 -0.000721 0.9950
REACTOME SIGNALING BY EGFR IN CANCER 82 0.991000 -0.000717 0.9950
REACTOME DNA REPLICATION 108 0.994000 -0.000389 0.9950


Detailed Gene set reports



REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
set REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
setSize 11
pANOVA 0.000419
s.dist 0.614
p.adjustANOVA 0.0974


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pygm 4753
Calm1 4741
Phka1 4739
Pgm1 4639
Agl 4476
Phkb 4468
Phkg1 4205
Gyg 4153
Phkg2 3267
Pygb -3367
Phka2 -3968

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pygm 4753
Calm1 4741
Phka1 4739
Pgm1 4639
Agl 4476
Phkb 4468
Phkg1 4205
Gyg 4153
Phkg2 3267
Pygb -3367
Phka2 -3968


REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
set REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
setSize 12
pANOVA 0.000829
s.dist 0.557
p.adjustANOVA 0.125


Top enriched genes
Top 20 genes
GeneID Gene Rank
Atp5a1 4738
Atp5e 4454
Atp5b 4420
Atp5d 4247
Atp5g1 4141
Atp5k 4010
Atp5j 3377
Atp5o 3075
Atp5j2 1991
Atp5h 1938
Atp5c1 -1340
Atp5l -3283

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5a1 4738
Atp5e 4454
Atp5b 4420
Atp5d 4247
Atp5g1 4141
Atp5k 4010
Atp5j 3377
Atp5o 3075
Atp5j2 1991
Atp5h 1938
Atp5c1 -1340
Atp5l -3283


REACTOME_COMPLEMENT_CASCADE
set REACTOME_COMPLEMENT_CASCADE
setSize 11
pANOVA 0.00401
s.dist -0.501
p.adjustANOVA 0.139


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cfd -4748
C4b -4728
C3 -4503
C1qa -4485
Cr1l -4354
Pros1 -2826
C1s1 -2756
C7 -1638
C1qb -50
Cd46 707
C1qc 3031

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cfd -4748
C4b -4728
C3 -4503
C1qa -4485
Cr1l -4354
Pros1 -2826
C1s1 -2756
C7 -1638
C1qb -50
Cd46 707
C1qc 3031


REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
set REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS
setSize 11
pANOVA 0.00447
s.dist -0.495
p.adjustANOVA 0.139


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fabp4 -4750
Plin1 -4671
Mgll -4571
Cav1 -4530
Abhd5 -4091
Ppp1cb -3383
Lipe -2506
Prkaca -2215
Ppp1ca -519
Prkacb 1868
Ppp1cc 3336

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fabp4 -4750
Plin1 -4671
Mgll -4571
Cav1 -4530
Abhd5 -4091
Ppp1cb -3383
Lipe -2506
Prkaca -2215
Ppp1ca -519
Prkacb 1868
Ppp1cc 3336


REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
set REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
setSize 17
pANOVA 0.00265
s.dist -0.421
p.adjustANOVA 0.137


Top enriched genes
Top 20 genes
GeneID Gene Rank
Crk -4396
Rap1a -4393
Akt1 -4119
Grb2 -4025
Bcar1 -3881
Fn1 -3590
Csk -3490
Ptpn1 -3426
Rap1b -3152
Ptk2 -2353
Vwf -629
Pdpk1 -447
Sos1 -384
Shc1 661
Tln1 856
Rasgrp2 998
Rapgef3 1542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crk -4396
Rap1a -4393
Akt1 -4119
Grb2 -4025
Bcar1 -3881
Fn1 -3590
Csk -3490
Ptpn1 -3426
Rap1b -3152
Ptk2 -2353
Vwf -629
Pdpk1 -447
Sos1 -384
Shc1 661
Tln1 856
Rasgrp2 998
Rapgef3 1542


REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION
set REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION
setSize 18
pANOVA 0.00229
s.dist -0.415
p.adjustANOVA 0.133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Crk -4396
Rap1a -4393
Akt1 -4119
Grb2 -4025
Bcar1 -3881
Fn1 -3590
Csk -3490
Ptpn1 -3426
Rap1b -3152
Ptk2 -2353
Thpo -1505
Vwf -629
Pdpk1 -447
Sos1 -384
Shc1 661
Tln1 856
Rasgrp2 998
Rapgef3 1542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crk -4396
Rap1a -4393
Akt1 -4119
Grb2 -4025
Bcar1 -3881
Fn1 -3590
Csk -3490
Ptpn1 -3426
Rap1b -3152
Ptk2 -2353
Thpo -1505
Vwf -629
Pdpk1 -447
Sos1 -384
Shc1 661
Tln1 856
Rasgrp2 998
Rapgef3 1542


REACTOME_SIGNAL_ATTENUATION
set REACTOME_SIGNAL_ATTENUATION
setSize 10
pANOVA 0.024
s.dist -0.412
p.adjustANOVA 0.392


Top enriched genes
Top 20 genes
GeneID Gene Rank
Crk -4396
Irs1 -4121
Grb2 -4025
Grb10 -3472
Shc2 -3432
Irs2 -1349
Mapk3 -623
Sos1 -384
Shc1 661
Insr 1422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crk -4396
Irs1 -4121
Grb2 -4025
Grb10 -3472
Shc2 -3432
Irs2 -1349
Mapk3 -623
Sos1 -384
Shc1 661
Insr 1422


REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING
set REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING
setSize 12
pANOVA 0.0155
s.dist -0.404
p.adjustANOVA 0.314


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cbl -4134
Ppp2ca -4080
Grb2 -4025
Mknk1 -3395
Mapk1 -2905
Ppp2cb -2726
Rps27a -2188
Spry2 -1283
Braf -1091
Mapk3 -623
Uba52 1075
Ppp2r1a 2210

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cbl -4134
Ppp2ca -4080
Grb2 -4025
Mknk1 -3395
Mapk1 -2905
Ppp2cb -2726
Rps27a -2188
Spry2 -1283
Braf -1091
Mapk3 -623
Uba52 1075
Ppp2r1a 2210


REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
set REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
setSize 19
pANOVA 0.00295
s.dist 0.394
p.adjustANOVA 0.137


Top enriched genes
Top 20 genes
GeneID Gene Rank
Aco2 4735
Idh3g 4700
Mdh2 4663
Cs 4564
Dlst 4395
Sdha 4265
Sdhd 3499
Sdhc 3395
Idh3a 3259
Suclg2 3153
Suclg1 2818
Ogdh 1992
Idh3b 1821
Sucla2 1110
Fh1 907
Dld -1433
Sdhb -3214
Nnt -4487
Idh2 -4648

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aco2 4735
Idh3g 4700
Mdh2 4663
Cs 4564
Dlst 4395
Sdha 4265
Sdhd 3499
Sdhc 3395
Idh3a 3259
Suclg2 3153
Suclg1 2818
Ogdh 1992
Idh3b 1821
Sucla2 1110
Fh1 907
Dld -1433
Sdhb -3214
Nnt -4487
Idh2 -4648


REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE
set REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE
setSize 16
pANOVA 0.00768
s.dist -0.385
p.adjustANOVA 0.188


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rhob -4585
Fyn -4416
Akt1 -4119
Pik3r1 -4013
Col1a1 -4000
Akt3 -3626
Col1a2 -3473
Rac1 -3120
Cdc42 -2969
Pik3cb -1811
Pdpk1 -447
Rhog -314
Pik3r2 628
Akt2 870
Pik3ca 1780
Pik3r3 4151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rhob -4585
Fyn -4416
Akt1 -4119
Pik3r1 -4013
Col1a1 -4000
Akt3 -3626
Col1a2 -3473
Rac1 -3120
Cdc42 -2969
Pik3cb -1811
Pdpk1 -447
Rhog -314
Pik3r2 628
Akt2 870
Pik3ca 1780
Pik3r3 4151


REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING
set REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING
setSize 10
pANOVA 0.0366
s.dist -0.382
p.adjustANOVA 0.461


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ablim1 -4746
Fyn -4416
Ntn1 -3721
Rac1 -3120
Cdc42 -2969
Nck1 -2788
Ptk2 -2353
Wasl -454
Ablim3 1685
Trio 4606

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ablim1 -4746
Fyn -4416
Ntn1 -3721
Rac1 -3120
Cdc42 -2969
Nck1 -2788
Ptk2 -2353
Wasl -454
Ablim3 1685
Trio 4606


REACTOME_GLUCONEOGENESIS
set REACTOME_GLUCONEOGENESIS
setSize 21
pANOVA 0.00325
s.dist 0.371
p.adjustANOVA 0.137


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gpi1 4729
Eno3 4725
Pgk1 4698
Slc25a12 4684
Mdh2 4663
Got2 4456
Pcx 3973
Tpi1 3570
Pfkfb1 3368
Pgam2 3258
Prkacb 1868
Eno1 1709
Pgam1 1548
Mdh1 1461
Got1 1283
Fbp2 1189
Slc25a11 -828
Prkaca -2215
Slc25a10 -2453
Pck1 -4167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpi1 4729
Eno3 4725
Pgk1 4698
Slc25a12 4684
Mdh2 4663
Got2 4456
Pcx 3973
Tpi1 3570
Pfkfb1 3368
Pgam2 3258
Prkacb 1868
Eno1 1709
Pgam1 1548
Mdh1 1461
Got1 1283
Fbp2 1189
Slc25a11 -828
Prkaca -2215
Slc25a10 -2453
Pck1 -4167
Slc25a1 -4592


REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE
set REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE
setSize 13
pANOVA 0.0269
s.dist 0.355
p.adjustANOVA 0.404


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc36a1 4550
Slc38a4 4515
Slc3a2 4303
Slc6a6 3918
Slc16a10 2859
Slc7a8 2609
Slc7a6 2312
Slc7a2 1815
Slc38a3 1715
Slc38a2 1578
Slc43a2 -620
Slc43a1 -2958
Slc1a5 -4744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc36a1 4550
Slc38a4 4515
Slc3a2 4303
Slc6a6 3918
Slc16a10 2859
Slc7a8 2609
Slc7a6 2312
Slc7a2 1815
Slc38a3 1715
Slc38a2 1578
Slc43a2 -620
Slc43a1 -2958
Slc1a5 -4744


REACTOME_METABOLISM_OF_POLYAMINES
set REACTOME_METABOLISM_OF_POLYAMINES
setSize 11
pANOVA 0.0464
s.dist 0.347
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mri1 4211
Adi1 4191
Apip 4026
Odc1 3745
Smox 3302
Amd1 3078
Got1 1283
Mtap 122
Sat1 -783
Enoph1 -2360
Sms -2720

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mri1 4211
Adi1 4191
Apip 4026
Odc1 3745
Smox 3302
Amd1 3078
Got1 1283
Mtap 122
Sat1 -783
Enoph1 -2360
Sms -2720


REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
set REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
setSize 11
pANOVA 0.0481
s.dist 0.344
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Paics 4390
Impdh1 4292
Ppat 4278
Adssl1 4035
Adss 3344
Impdh2 2442
Adsl 1890
Atic 191
Pfas -997
Gart -1532
Gmps -4380

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Paics 4390
Impdh1 4292
Ppat 4278
Adssl1 4035
Adss 3344
Impdh2 2442
Adsl 1890
Atic 191
Pfas -997
Gart -1532
Gmps -4380


REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT
set REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT
setSize 22
pANOVA 0.00684
s.dist -0.333
p.adjustANOVA 0.181


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fabp4 -4750
Lpl -4747
Apoe -4738
Plin1 -4671
Mgll -4571
Cav1 -4530
Abhd5 -4091
Bmp1 -3995
Ppp1cb -3383
Pltp -2924
Lipe -2506
Hspg2 -2448
Prkaca -2215
Ldlrap1 -1208
Ppp1ca -519
Ldlr 833
Sar1b 946
Prkacb 1868
P4hb 2277
Abca1 3006

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fabp4 -4750
Lpl -4747
Apoe -4738
Plin1 -4671
Mgll -4571
Cav1 -4530
Abhd5 -4091
Bmp1 -3995
Ppp1cb -3383
Pltp -2924
Lipe -2506
Hspg2 -2448
Prkaca -2215
Ldlrap1 -1208
Ppp1ca -519
Ldlr 833
Sar1b 946
Prkacb 1868
P4hb 2277
Abca1 3006
Ppp1cc 3336
Scarb1 3967


REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
set REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
setSize 20
pANOVA 0.0104
s.dist 0.331
p.adjustANOVA 0.241


Top enriched genes
Top 20 genes
GeneID Gene Rank
Lars2 4757.0
Iars2 4608.0
Rars2 4594.0
Kars 4465.0
Fars2 4455.0
Nars2 4273.0
Yars2 4178.0
Vars2 2896.0
Aars2 2568.0
Gars 2358.0
Qars 1268.0
Hars2 1196.0
Dars2 1024.0
Wars2 565.0
Cars2 -887.0
Ppa2 -1358.0
Tars2 -1443.0
Ears2 -1858.5
Mars2 -2710.0
Sars2 -3580.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lars2 4757.0
Iars2 4608.0
Rars2 4594.0
Kars 4465.0
Fars2 4455.0
Nars2 4273.0
Yars2 4178.0
Vars2 2896.0
Aars2 2568.0
Gars 2358.0
Qars 1268.0
Hars2 1196.0
Dars2 1024.0
Wars2 565.0
Cars2 -887.0
Ppa2 -1358.0
Tars2 -1443.0
Ears2 -1858.5
Mars2 -2710.0
Sars2 -3580.0


REACTOME_GLUTATHIONE_CONJUGATION
set REACTOME_GLUTATHIONE_CONJUGATION
setSize 12
pANOVA 0.0474
s.dist 0.331
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gstp1 4699
Gss 4438
Gstm4 4394
Mgst3 4181
Oplah 4048
Gclm 4046
Cndp2 4023
Gstm2 -557
Gsto1 -1629
Gclc -2343
Mgst1 -2900
Ggct -3598

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gstp1 4699
Gss 4438
Gstm4 4394
Mgst3 4181
Oplah 4048
Gclm 4046
Cndp2 4023
Gstm2 -557
Gsto1 -1629
Gclc -2343
Mgst1 -2900
Ggct -3598


REACTOME_CTLA4_INHIBITORY_SIGNALING
set REACTOME_CTLA4_INHIBITORY_SIGNALING
setSize 15
pANOVA 0.0317
s.dist -0.32
p.adjustANOVA 0.447


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fyn -4416
Ppp2r1b -4347
Akt1 -4119
Ppp2ca -4080
Akt3 -3626
Ppp2cb -2726
Yes1 -2404
Ppp2r5e -2041
Pdpk1 -447
Ppp2r5d -186
Ppp2r5a -70
Ppp2r5c 604
Akt2 870
Ppp2r5b 1770
Ppp2r1a 2210

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fyn -4416
Ppp2r1b -4347
Akt1 -4119
Ppp2ca -4080
Akt3 -3626
Ppp2cb -2726
Yes1 -2404
Ppp2r5e -2041
Pdpk1 -447
Ppp2r5d -186
Ppp2r5a -70
Ppp2r5c 604
Akt2 870
Ppp2r5b 1770
Ppp2r1a 2210


REACTOME_DOUBLE_STRAND_BREAK_REPAIR
set REACTOME_DOUBLE_STRAND_BREAK_REPAIR
setSize 12
pANOVA 0.0675
s.dist 0.305
p.adjustANOVA 0.527


Top enriched genes
Top 20 genes
GeneID Gene Rank
Trp53bp1 4687
Rpa1 4602
Xrcc5 4511
Nbn 3230
Xrcc6 3124
Prkdc 2966
Atm 2659
Lig4 1208
Rpa2 260
Xrcc4 -2143
Rad52 -3103
Rad50 -4665

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Trp53bp1 4687
Rpa1 4602
Xrcc5 4511
Nbn 3230
Xrcc6 3124
Prkdc 2966
Atm 2659
Lig4 1208
Rpa2 260
Xrcc4 -2143
Rad52 -3103
Rad50 -4665


REACTOME_REGULATION_OF_SIGNALING_BY_CBL
set REACTOME_REGULATION_OF_SIGNALING_BY_CBL
setSize 13
pANOVA 0.0581
s.dist -0.304
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fyn -4416
Crk -4396
Cbl -4134
Grb2 -4025
Pik3r1 -4013
Rapgef1 -3887
Yes1 -2404
Pik3cb -1811
Crkl 109
Pik3r2 628
Pik3ca 1780
Pik3cd 3511
Pik3r3 4151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fyn -4416
Crk -4396
Cbl -4134
Grb2 -4025
Pik3r1 -4013
Rapgef1 -3887
Yes1 -2404
Pik3cb -1811
Crkl 109
Pik3r2 628
Pik3ca 1780
Pik3cd 3511
Pik3r3 4151


REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION
set REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION
setSize 19
pANOVA 0.0248
s.dist 0.298
p.adjustANOVA 0.392


Top enriched genes
Top 20 genes
GeneID Gene Rank
Polr2h 4666
Taf1c 4654
Ubtf 4400
Gtf2h4 4173
Gtf2h1 3867
Polr1a 3845
Polr1b 3808
Ccnh 2111
Mnat1 2103
Gtf2h3 1841
Polr1d 1828
Polr1c 1788
Cdk7 1134
Taf1a 732
Polr2k -363
Ercc2 -2524
Ercc3 -3181
Taf1b -3474
Gtf2h2 -4643

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Polr2h 4666
Taf1c 4654
Ubtf 4400
Gtf2h4 4173
Gtf2h1 3867
Polr1a 3845
Polr1b 3808
Ccnh 2111
Mnat1 2103
Gtf2h3 1841
Polr1d 1828
Polr1c 1788
Cdk7 1134
Taf1a 732
Polr2k -363
Ercc2 -2524
Ercc3 -3181
Taf1b -3474
Gtf2h2 -4643


REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
set REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize 13
pANOVA 0.0647
s.dist 0.296
p.adjustANOVA 0.519


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pcca 4585
Acads 4284
Hadha 4028
Pccb 3982
Hadh 3535
Acadl 3458
Acadvl 823
Echs1 802
Acadm 201
Hadhb -85
Mcee -254
Decr1 -2414
Eci1 -4721

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pcca 4585
Acads 4284
Hadha 4028
Pccb 3982
Hadh 3535
Acadl 3458
Acadvl 823
Echs1 802
Acadm 201
Hadhb -85
Mcee -254
Decr1 -2414
Eci1 -4721


REACTOME_ION_CHANNEL_TRANSPORT
set REACTOME_ION_CHANNEL_TRANSPORT
setSize 18
pANOVA 0.0328
s.dist -0.291
p.adjustANOVA 0.448


Top enriched genes
Top 20 genes
GeneID Gene Rank
Atp2a2 -4706
Atp11c -3681
Atp1b1 -3451
Atp1a1 -3361
Atp7a -3136
Arhgef9 -2784
Atp11a -2680
Atp2c1 -2226
Atp9a -1997
Atp1b2 -1902
Atp9b -1752
Atp1b3 -1700
Atp11b -907
Atp2b3 -897
Atp2a3 110
Atp1a2 2057
Atp8a1 3287
Atp2a1 4664

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp2a2 -4706
Atp11c -3681
Atp1b1 -3451
Atp1a1 -3361
Atp7a -3136
Arhgef9 -2784
Atp11a -2680
Atp2c1 -2226
Atp9a -1997
Atp1b2 -1902
Atp9b -1752
Atp1b3 -1700
Atp11b -907
Atp2b3 -897
Atp2a3 110
Atp1a2 2057
Atp8a1 3287
Atp2a1 4664


REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING
set REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING
setSize 17
pANOVA 0.0397
s.dist -0.288
p.adjustANOVA 0.461


Top enriched genes
Top 20 genes
GeneID Gene Rank
Frs2 -4537
Fgf1 -4500
Cbl -4134
Ppp2ca -4080
Grb2 -4025
Mknk1 -3395
Mapk1 -2905
Ppp2cb -2726
Rps27a -2188
Spry2 -1283
Braf -1091
Mapk3 -623
Uba52 1075
Fgfr1 1387
Ppp2r1a 2210
Fgf2 2821
Fgf6 4523

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Frs2 -4537
Fgf1 -4500
Cbl -4134
Ppp2ca -4080
Grb2 -4025
Mknk1 -3395
Mapk1 -2905
Ppp2cb -2726
Rps27a -2188
Spry2 -1283
Braf -1091
Mapk3 -623
Uba52 1075
Fgfr1 1387
Ppp2r1a 2210
Fgf2 2821
Fgf6 4523


REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS
set REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS
setSize 16
pANOVA 0.0497
s.dist 0.283
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc36a1 4550
Slc38a4 4515
Slc3a2 4303
Slc6a6 3918
Slc15a2 3488
Slc16a10 2859
Slc7a8 2609
Slc7a6 2312
Slc7a2 1815
Slc38a3 1715
Slc38a2 1578
Slc43a2 -620
Slc15a4 -1417
Slc25a10 -2453
Slc43a1 -2958
Slc1a5 -4744

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc36a1 4550
Slc38a4 4515
Slc3a2 4303
Slc6a6 3918
Slc15a2 3488
Slc16a10 2859
Slc7a8 2609
Slc7a6 2312
Slc7a2 1815
Slc38a3 1715
Slc38a2 1578
Slc43a2 -620
Slc15a4 -1417
Slc25a10 -2453
Slc43a1 -2958
Slc1a5 -4744


REACTOME_TRNA_AMINOACYLATION
set REACTOME_TRNA_AMINOACYLATION
setSize 39
pANOVA 0.00225
s.dist 0.283
p.adjustANOVA 0.133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Lars2 4757
Farsa 4711
Iars2 4608
Rars2 4594
Kars 4465
Fars2 4455
Eprs 4452
Iars 4436
Nars2 4273
Aars 4269
Yars2 4178
Sars 4100
Rars 3742
Farsb 3149
Vars2 2896
Vars 2741
Aars2 2568
Tars 2482
Gars 2358
Nars 2167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lars2 4757.0
Farsa 4711.0
Iars2 4608.0
Rars2 4594.0
Kars 4465.0
Fars2 4455.0
Eprs 4452.0
Iars 4436.0
Nars2 4273.0
Aars 4269.0
Yars2 4178.0
Sars 4100.0
Rars 3742.0
Farsb 3149.0
Vars2 2896.0
Vars 2741.0
Aars2 2568.0
Tars 2482.0
Gars 2358.0
Nars 2167.0
Qars 1268.0
Hars2 1196.0
Yars 1111.0
Dars2 1024.0
Wars 676.0
Wars2 565.0
Ppa1 231.0
Aimp2 -58.0
Cars2 -887.0
Ppa2 -1358.0
Tars2 -1443.0
Ears2 -1858.5
Lars -2218.0
Mars2 -2710.0
Dars -3502.0
Sars2 -3580.0
Hars -3802.0
Aimp1 -3925.0
Cars -4011.0


REACTOME_METABOLISM_OF_PORPHYRINS
set REACTOME_METABOLISM_OF_PORPHYRINS
setSize 11
pANOVA 0.105
s.dist 0.282
p.adjustANOVA 0.65


Top enriched genes
Top 20 genes
GeneID Gene Rank
Alas1 4728
Alad 4500
Urod 3003
Hmox1 2615
Blvra 2334
Cpox 1039
Hmox2 805
Fech -33
Hmbs -637
Ppox -1143
Uros -2495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Alas1 4728
Alad 4500
Urod 3003
Hmox1 2615
Blvra 2334
Cpox 1039
Hmox2 805
Fech -33
Hmbs -637
Ppox -1143
Uros -2495


REACTOME_GLUCOSE_METABOLISM
set REACTOME_GLUCOSE_METABOLISM
setSize 46
pANOVA 0.00107
s.dist 0.279
p.adjustANOVA 0.125


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pygm 4753
Calm1 4741
Phka1 4739
Pfkm 4737
Gpi1 4729
Eno3 4725
Pgk1 4698
Slc25a12 4684
Mdh2 4663
Pgm1 4639
Agl 4476
Phkb 4468
Got2 4456
Phkg1 4205
Gyg 4153
Pcx 3973
Tpi1 3570
Pfkfb1 3368
Phkg2 3267
Pgam2 3258

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pygm 4753
Calm1 4741
Phka1 4739
Pfkm 4737
Gpi1 4729
Eno3 4725
Pgk1 4698
Slc25a12 4684
Mdh2 4663
Pgm1 4639
Agl 4476
Phkb 4468
Got2 4456
Phkg1 4205
Gyg 4153
Pcx 3973
Tpi1 3570
Pfkfb1 3368
Phkg2 3267
Pgam2 3258
Pfkfb3 3173
Ppp2r1a 2210
Pfkp 2144
Prkacb 1868
Eno1 1709
Pgam1 1548
Mdh1 1461
Got1 1283
Fbp2 1189
Gbe1 7
Ppp2r5d -186
Ugp2 -600
Slc25a11 -828
Pfkfb4 -1525
Pfkfb2 -1591
Prkaca -2215
Slc25a10 -2453
Pfkl -2675
Ppp2cb -2726
Gys1 -3006
Pygb -3367
Phka2 -3968
Ppp2ca -4080
Pck1 -4167
Ppp2r1b -4347
Slc25a1 -4592


REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
set REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
setSize 22
pANOVA 0.0245
s.dist 0.277
p.adjustANOVA 0.392


Top enriched genes
Top 20 genes
GeneID Gene Rank
Farsa 4711
Kars 4465
Eprs 4452
Iars 4436
Aars 4269
Sars 4100
Rars 3742
Farsb 3149
Vars 2741
Tars 2482
Gars 2358
Nars 2167
Qars 1268
Yars 1111
Wars 676
Ppa1 231
Aimp2 -58
Lars -2218
Dars -3502
Hars -3802

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Farsa 4711
Kars 4465
Eprs 4452
Iars 4436
Aars 4269
Sars 4100
Rars 3742
Farsb 3149
Vars 2741
Tars 2482
Gars 2358
Nars 2167
Qars 1268
Yars 1111
Wars 676
Ppa1 231
Aimp2 -58
Lars -2218
Dars -3502
Hars -3802
Aimp1 -3925
Cars -4011


REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
set REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
setSize 13
pANOVA 0.0848
s.dist 0.276
p.adjustANOVA 0.597


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4b 4619
Tcp1 4368
Cct8 3989
Cct3 3825
Cct7 3779
Tuba4a 3277
Cct2 2642
Cct5 1077
Tuba1a 695
Cct4 -1380
Tubb6 -2416
Tubb2a -2876
Tuba1b -4602

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 4619
Tcp1 4368
Cct8 3989
Cct3 3825
Cct7 3779
Tuba4a 3277
Cct2 2642
Cct5 1077
Tuba1a 695
Cct4 -1380
Tubb6 -2416
Tubb2a -2876
Tuba1b -4602


REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES
set REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES
setSize 17
pANOVA 0.051
s.dist -0.274
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Atp2a2 -4706
Atp11c -3681
Atp1b1 -3451
Atp1a1 -3361
Atp7a -3136
Atp11a -2680
Atp2c1 -2226
Atp9a -1997
Atp1b2 -1902
Atp9b -1752
Atp1b3 -1700
Atp11b -907
Atp2b3 -897
Atp2a3 110
Atp1a2 2057
Atp8a1 3287
Atp2a1 4664

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp2a2 -4706
Atp11c -3681
Atp1b1 -3451
Atp1a1 -3361
Atp7a -3136
Atp11a -2680
Atp2c1 -2226
Atp9a -1997
Atp1b2 -1902
Atp9b -1752
Atp1b3 -1700
Atp11b -907
Atp2b3 -897
Atp2a3 110
Atp1a2 2057
Atp8a1 3287
Atp2a1 4664


REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS
set REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS
setSize 12
pANOVA 0.101
s.dist -0.273
p.adjustANOVA 0.645


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fasn -4736
Acly -4658
Slc25a1 -4592
Hsd17b12 -4321
Acsl4 -3411
Acsl3 -1404
Acsl6 -634
Acsl5 -297
Tecr -118
Acaca 2264
Acsl1 2541
Elovl5 3648

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fasn -4736
Acly -4658
Slc25a1 -4592
Hsd17b12 -4321
Acsl4 -3411
Acsl3 -1404
Acsl6 -634
Acsl5 -297
Tecr -118
Acaca 2264
Acsl1 2541
Elovl5 3648


REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY
set REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY
setSize 11
pANOVA 0.117
s.dist -0.273
p.adjustANOVA 0.7


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tuba1b -4602
Tbca -4039
Tbce -3579
Tbcc -2884
Tubb2a -2876
Tubb6 -2416
Tbcb -1762
Tbcd -813
Tuba1a 695
Tuba4a 3277
Tubb4b 4619

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tuba1b -4602
Tbca -4039
Tbce -3579
Tbcc -2884
Tubb2a -2876
Tubb6 -2416
Tbcb -1762
Tbcd -813
Tuba1a 695
Tuba4a 3277
Tubb4b 4619


REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS
set REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS
setSize 43
pANOVA 0.00221
s.dist -0.27
p.adjustANOVA 0.133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Itgb1 -4598
Fbn1 -4518
Jam2 -4424
Crk -4396
Rap1a -4393
Akt1 -4119
Grb2 -4025
Col1a1 -4000
Bcar1 -3881
Itgb6 -3789
Fn1 -3590
Csk -3490
Col1a2 -3473
Ptpn1 -3426
Lamb1 -3206
Rap1b -3152
Col4a5 -2693
Itga9 -2688
Icam2 -2615
Itgav -2436

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itgb1 -4598
Fbn1 -4518
Jam2 -4424
Crk -4396
Rap1a -4393
Akt1 -4119
Grb2 -4025
Col1a1 -4000
Bcar1 -3881
Itgb6 -3789
Fn1 -3590
Csk -3490
Col1a2 -3473
Ptpn1 -3426
Lamb1 -3206
Rap1b -3152
Col4a5 -2693
Itga9 -2688
Icam2 -2615
Itgav -2436
Ptk2 -2353
Col4a1 -2338
Itga5 -2209
Itgb5 -991
Jam3 -802
Thbs1 -787
Vwf -629
Pdpk1 -447
Sos1 -384
Lama2 -127
Shc1 661
Tln1 856
Rasgrp2 998
Lamc1 1097
Pecam1 1266
Bsg 1436
Rapgef3 1542
Col4a2 1817
F11r 2474
Itga1 3883
Lama5 4052
Lamb2 4093
Vtn 4320


REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE
set REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE
setSize 14
pANOVA 0.091
s.dist 0.261
p.adjustANOVA 0.605


Top enriched genes
Top 20 genes
GeneID Gene Rank
Vac14 4261
Arf1 4204
Pik3r4 3257
Pi4kb 2790
Fig4 2445
Pik3c3 2041
Ocrl 1513
Inpp5e 1424
Pi4ka 199
Arf3 -108
Pikfyve -387
Pi4k2a -1026
Pik3c2a -1502
Sacm1l -1819

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Vac14 4261
Arf1 4204
Pik3r4 3257
Pi4kb 2790
Fig4 2445
Pik3c3 2041
Ocrl 1513
Inpp5e 1424
Pi4ka 199
Arf3 -108
Pikfyve -387
Pi4k2a -1026
Pik3c2a -1502
Sacm1l -1819


REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC
set REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC
setSize 19
pANOVA 0.0497
s.dist 0.26
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4b 4619
Tcp1 4368
Cct8 3989
Cct3 3825
Cct7 3779
Pfdn2 3618
Pfdn5 3341
Tuba4a 3277
Pfdn1 2716
Cct2 2642
Cct5 1077
Actb 795
Tuba1a 695
Pfdn6 -375
Cct4 -1380
Tubb6 -2416
Tubb2a -2876
Vbp1 -4004
Pfdn4 -4312

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 4619
Tcp1 4368
Cct8 3989
Cct3 3825
Cct7 3779
Pfdn2 3618
Pfdn5 3341
Tuba4a 3277
Pfdn1 2716
Cct2 2642
Cct5 1077
Actb 795
Tuba1a 695
Pfdn6 -375
Cct4 -1380
Tubb6 -2416
Tubb2a -2876
Vbp1 -4004
Pfdn4 -4312


REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
set REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
setSize 21
pANOVA 0.0393
s.dist -0.26
p.adjustANOVA 0.461


Top enriched genes
Top 20 genes
GeneID Gene Rank
Anxa1 -4567.0
C3 -4503.0
Lpar1 -4207.0
S1pr1 -4113.0
Aplnr -3834.0
Ednrb -3480.0
Adrb2 -3285.0
S1pr3 -2655.0
P2ry1 -2553.0
Ccl25 -1872.0
Agt -1022.0
Ccl11 -759.0
Ccr2 -26.0
Lpar6 93.5
Penk 341.0
Ccl27a 437.0
App 554.0
Pf4 615.0
Cxcl12 1509.0
P2ry2 2944.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Anxa1 -4567.0
C3 -4503.0
Lpar1 -4207.0
S1pr1 -4113.0
Aplnr -3834.0
Ednrb -3480.0
Adrb2 -3285.0
S1pr3 -2655.0
P2ry1 -2553.0
Ccl25 -1872.0
Agt -1022.0
Ccl11 -759.0
Ccr2 -26.0
Lpar6 93.5
Penk 341.0
Ccl27a 437.0
App 554.0
Pf4 615.0
Cxcl12 1509.0
P2ry2 2944.0
Mc5r 4241.0


REACTOME_TIE2_SIGNALING
set REACTOME_TIE2_SIGNALING
setSize 13
pANOVA 0.107
s.dist -0.258
p.adjustANOVA 0.65


Top enriched genes
Top 20 genes
GeneID Gene Rank
Grb14 -4593
Grb2 -4025
Pik3r1 -4013
Kras -3742
Tek -3194
Pik3cb -1811
Sos1 -384
Nras 433
Pik3r2 628
Angpt1 644
Shc1 661
Hras 1526
Pik3ca 1780

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grb14 -4593
Grb2 -4025
Pik3r1 -4013
Kras -3742
Tek -3194
Pik3cb -1811
Sos1 -384
Nras 433
Pik3r2 628
Angpt1 644
Shc1 661
Hras 1526
Pik3ca 1780


REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
set REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
setSize 11
pANOVA 0.139
s.dist -0.257
p.adjustANOVA 0.761


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fermt2 -4604
Itgb1 -4598
Rsu1 -4434
Flnc -3892
Tesk1 -2743
Lims1 -2587
Parva -1004
Ilk 1281
Parvb 1690
Vasp 2939
Arhgef6 4373

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fermt2 -4604
Itgb1 -4598
Rsu1 -4434
Flnc -3892
Tesk1 -2743
Lims1 -2587
Parva -1004
Ilk 1281
Parvb 1690
Vasp 2939
Arhgef6 4373


REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS
set REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS
setSize 11
pANOVA 0.143
s.dist -0.255
p.adjustANOVA 0.761


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mapk8 -4230
Akt1 -4119
Bcl2l11 -4110
Ppp3r1 -3207
Tfdp1 -3111
Dynll1 -3057
Bcl2 -2706
Trp53 1946
Dynll2 1978
Ywhab 3100
Bad 4051

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk8 -4230
Akt1 -4119
Bcl2l11 -4110
Ppp3r1 -3207
Tfdp1 -3111
Dynll1 -3057
Bcl2 -2706
Trp53 1946
Dynll2 1978
Ywhab 3100
Bad 4051


REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS
set REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS
setSize 16
pANOVA 0.0792
s.dist -0.254
p.adjustANOVA 0.566


Top enriched genes
Top 20 genes
GeneID Gene Rank
Frs2 -4537
Crk -4396
Rap1a -4393
Rapgef1 -3887
Kras -3742
Plcg1 -3225
Mapk1 -2905
Kidins220 -2851
Braf -1091
Mapk3 -623
Nras 433
Raf1 596
Hras 1526
Map2k1 3027
Ywhab 3100
Map2k2 3518

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Frs2 -4537
Crk -4396
Rap1a -4393
Rapgef1 -3887
Kras -3742
Plcg1 -3225
Mapk1 -2905
Kidins220 -2851
Braf -1091
Mapk3 -623
Nras 433
Raf1 596
Hras 1526
Map2k1 3027
Ywhab 3100
Map2k2 3518


REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
set REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
setSize 38
pANOVA 0.00699
s.dist 0.253
p.adjustANOVA 0.181


Top enriched genes
Top 20 genes
GeneID Gene Rank
Aco2 4735
Idh3g 4700
Mdh2 4663
Ldha 4631
Cs 4564
Pdhx 4488
Dlst 4395
Sdha 4265
Pdk2 4054
Sdhd 3499
Sdhc 3395
Idh3a 3259
Pdha1 3252
Suclg2 3153
Slc16a3 3128
Suclg1 2818
Pdp1 2093
Ogdh 1992
Dlat 1961
Idh3b 1821

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aco2 4735
Idh3g 4700
Mdh2 4663
Ldha 4631
Cs 4564
Pdhx 4488
Dlst 4395
Sdha 4265
Pdk2 4054
Sdhd 3499
Sdhc 3395
Idh3a 3259
Pdha1 3252
Suclg2 3153
Slc16a3 3128
Suclg1 2818
Pdp1 2093
Ogdh 1992
Dlat 1961
Idh3b 1821
D2hgdh 1499
Bsg 1436
Sucla2 1110
Fh1 907
Pdp2 876
Slc16a1 233
L2hgdh 72
Pdpr -967
Adhfe1 -1291
Dld -1433
Pdk1 -1972
Pdhb -2366
Pdk4 -3145
Sdhb -3214
Idh1 -3375
Nnt -4487
Idh2 -4648
Ldhb -4714


REACTOME_GLYCOLYSIS
set REACTOME_GLYCOLYSIS
setSize 19
pANOVA 0.0563
s.dist 0.253
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pfkm 4737
Gpi1 4729
Eno3 4725
Pgk1 4698
Tpi1 3570
Pfkfb1 3368
Pgam2 3258
Pfkfb3 3173
Ppp2r1a 2210
Pfkp 2144
Eno1 1709
Pgam1 1548
Ppp2r5d -186
Pfkfb4 -1525
Pfkfb2 -1591
Pfkl -2675
Ppp2cb -2726
Ppp2ca -4080
Ppp2r1b -4347

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pfkm 4737
Gpi1 4729
Eno3 4725
Pgk1 4698
Tpi1 3570
Pfkfb1 3368
Pgam2 3258
Pfkfb3 3173
Ppp2r1a 2210
Pfkp 2144
Eno1 1709
Pgam1 1548
Ppp2r5d -186
Pfkfb4 -1525
Pfkfb2 -1591
Pfkl -2675
Ppp2cb -2726
Ppp2ca -4080
Ppp2r1b -4347


REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL
set REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL
setSize 44
pANOVA 0.00409
s.dist -0.25
p.adjustANOVA 0.139


Top enriched genes
Top 20 genes
GeneID Gene Rank
Itgb1 -4598
Grb14 -4593
Cav1 -4530
Jam2 -4424
Fyn -4416
Grb2 -4025
Pik3r1 -4013
Col1a1 -4000
Kras -3742
Ppil2 -3674
Fn1 -3590
Col1a2 -3473
Atp1b1 -3451
Ppia -3391
Plcg1 -3225
Tek -3194
Pros1 -2826
Itgav -2436
Yes1 -2404
Itga5 -2209

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itgb1 -4598
Grb14 -4593
Cav1 -4530
Jam2 -4424
Fyn -4416
Grb2 -4025
Pik3r1 -4013
Col1a1 -4000
Kras -3742
Ppil2 -3674
Fn1 -3590
Col1a2 -3473
Atp1b1 -3451
Ppia -3391
Plcg1 -3225
Tek -3194
Pros1 -2826
Itgav -2436
Yes1 -2404
Itga5 -2209
Atp1b2 -1902
Pik3cb -1811
Atp1b3 -1700
Cd47 -1534
Esam -1386
Jam3 -802
Sos1 -384
Slc16a1 233
Nras 433
Pf4 615
Pik3r2 628
Angpt1 644
Shc1 661
Pecam1 1266
Bsg 1436
Hras 1526
Pik3ca 1780
Thbd 2007
Slc7a6 2312
F11r 2474
Slc7a8 2609
Sirpa 3005
Slc16a3 3128
Slc3a2 4303


REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES
set REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES
setSize 15
pANOVA 0.0947
s.dist 0.249
p.adjustANOVA 0.611


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc35c1 4277
Slc28a2 4232
Slc27a4 2588
Slc5a6 2483
Slc35d1 2080
Slc29a1 1896
Slc35a1 1851
Slco3a1 1282
Slc35b4 1258
Slco2b1 1230
Slc27a1 -171
Slc35a2 -246
Slc33a1 -876
Slc35a3 -1290
Slc35b2 -2903

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc35c1 4277
Slc28a2 4232
Slc27a4 2588
Slc5a6 2483
Slc35d1 2080
Slc29a1 1896
Slc35a1 1851
Slco3a1 1282
Slc35b4 1258
Slco2b1 1230
Slc27a1 -171
Slc35a2 -246
Slc33a1 -876
Slc35a3 -1290
Slc35b2 -2903


REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
set REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
setSize 10
pANOVA 0.19
s.dist -0.24
p.adjustANOVA 0.782


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gnaq -4408
Gna11 -3689
Gng12 -2277
Gnb4 -2254
Gna13 -1813
Gng11 -971
Gnb5 202
Gnb2 466
Gng5 693
Gnb1 2559

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnaq -4408
Gna11 -3689
Gng12 -2277
Gnb4 -2254
Gna13 -1813
Gng11 -971
Gnb5 202
Gnb2 466
Gng5 693
Gnb1 2559


REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA
set REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA
setSize 11
pANOVA 0.173
s.dist -0.237
p.adjustANOVA 0.781


Top enriched genes
Top 20 genes
GeneID Gene Rank
Atf6 -4227
Ddit3 -3868
Mbtps1 -3812
Nfyb -3141
Xbp1 -3067
Hsp90b1 -2894
Hspa5 -1565
Calr 1263
Atf4 1389
Mbtps2 3116
Nfya 4291

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atf6 -4227
Ddit3 -3868
Mbtps1 -3812
Nfyb -3141
Xbp1 -3067
Hsp90b1 -2894
Hspa5 -1565
Calr 1263
Atf4 1389
Mbtps2 3116
Nfya 4291


REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS
set REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS
setSize 22
pANOVA 0.0547
s.dist 0.237
p.adjustANOVA 0.476


Top enriched genes
Top 20 genes
GeneID Gene Rank
Lonp2 4463
Tcp1 4368
Cct8 3989
Cct3 3825
Xrn2 3803
Cct7 3779
Kif13a 3241
Fbxl3 3132
Fbxl5 2981
Cct2 2642
Fkbp9 1927
Cct5 1077
Fbxo6 890
Fbxw2 2
Fbxw5 -977
Nop56 -982
Arfgef2 -1080
Cct4 -1380
Fbxw4 -2098
Kifc3 -2531

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lonp2 4463
Tcp1 4368
Cct8 3989
Cct3 3825
Xrn2 3803
Cct7 3779
Kif13a 3241
Fbxl3 3132
Fbxl5 2981
Cct2 2642
Fkbp9 1927
Cct5 1077
Fbxo6 890
Fbxw2 2
Fbxw5 -977
Nop56 -982
Arfgef2 -1080
Cct4 -1380
Fbxw4 -2098
Kifc3 -2531
Fbxw7 -2732
Ap3m1 -3726


REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
set REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
setSize 34
pANOVA 0.0179
s.dist -0.235
p.adjustANOVA 0.319


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col3a1 -4739
Timp2 -4006
Col1a1 -4000
Bmp1 -3995
Adamts2 -3851
Col22a1 -3660
Mmp2 -3507
Col1a2 -3473
Plod3 -2912
Col4a5 -2693
Crtap -2690
Col6a3 -2613
Pcolce2 -2508
Pcolce -2499
Mmp14 -2477
Col4a1 -2338
Col6a1 -2230
Ppib -2099
Col14a1 -1793
Col5a2 -1749

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col3a1 -4739
Timp2 -4006
Col1a1 -4000
Bmp1 -3995
Adamts2 -3851
Col22a1 -3660
Mmp2 -3507
Col1a2 -3473
Plod3 -2912
Col4a5 -2693
Crtap -2690
Col6a3 -2613
Pcolce2 -2508
Pcolce -2499
Mmp14 -2477
Col4a1 -2338
Col6a1 -2230
Ppib -2099
Col14a1 -1793
Col5a2 -1749
Col24a1 -1706
Col5a1 -862
Furin -229
Mmp15 243
Col11a2 453
Col5a3 1051
Col9a1 1177
Col15a1 1197
Col4a2 1817
P4hb 2277
Col6a2 3402
Serpinh1 3791
Plod1 4327
Col7a1 4661


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] gtools_3.9.5                echarts4r_0.4.5            
##  [5] beeswarm_0.4.0              vioplot_0.5.0              
##  [7] sm_2.2-6.0                  kableExtra_1.4.0           
##  [9] topconfects_1.22.0          limma_3.62.1               
## [11] eulerr_7.0.2                mitch_1.18.4               
## [13] MASS_7.3-64                 fgsea_1.32.2               
## [15] gplots_3.2.0                DESeq2_1.46.0              
## [17] SummarizedExperiment_1.36.0 Biobase_2.66.0             
## [19] MatrixGenerics_1.18.0       matrixStats_1.4.1          
## [21] GenomicRanges_1.58.0        GenomeInfoDb_1.42.1        
## [23] IRanges_2.40.1              S4Vectors_0.44.0           
## [25] BiocGenerics_0.52.0         reshape2_1.4.4             
## [27] lubridate_1.9.4             forcats_1.0.0              
## [29] stringr_1.5.1               dplyr_1.1.4                
## [31] purrr_1.0.2                 readr_2.1.5                
## [33] tidyr_1.3.1                 tibble_3.2.1               
## [35] ggplot2_3.5.1               tidyverse_2.0.0            
## [37] zoo_1.8-12                  plyr_1.8.9                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-9            gridExtra_2.3           rlang_1.1.4            
##  [4] magrittr_2.0.3          compiler_4.4.2          systemfonts_1.1.0      
##  [7] vctrs_0.6.5             pkgconfig_2.0.3         crayon_1.5.3           
## [10] fastmap_1.2.0           XVector_0.46.0          caTools_1.18.3         
## [13] promises_1.3.2          rmarkdown_2.29          tzdb_0.4.0             
## [16] UCSC.utils_1.2.0        xfun_0.49               zlibbioc_1.52.0        
## [19] cachem_1.1.0            jsonlite_1.8.9          later_1.4.1            
## [22] DelayedArray_0.32.0     BiocParallel_1.40.0     parallel_4.4.2         
## [25] R6_2.5.1                bslib_0.8.0             stringi_1.8.4          
## [28] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [31] Rcpp_1.0.13-1           knitr_1.49              httpuv_1.6.15          
## [34] Matrix_1.7-1            timechange_0.3.0        tidyselect_1.2.1       
## [37] rstudioapi_0.17.1       abind_1.4-8             yaml_2.3.10            
## [40] codetools_0.2-20        lattice_0.22-6          shiny_1.10.0           
## [43] withr_3.0.2             evaluate_1.0.1          ggstats_0.7.0          
## [46] xml2_1.3.6              pillar_1.10.0           KernSmooth_2.23-24     
## [49] generics_0.1.3          hms_1.1.3               munsell_0.5.1          
## [52] scales_1.3.0            xtable_1.8-4            glue_1.8.0             
## [55] tools_4.4.2             data.table_1.16.4       locfit_1.5-9.10        
## [58] fastmatch_1.1-6         cowplot_1.1.3           grid_4.4.2             
## [61] colorspace_2.1-1        GenomeInfoDbData_1.2.13 cli_3.6.3              
## [64] S4Arrays_1.6.0          viridisLite_0.4.2       svglite_2.1.3          
## [67] gtable_0.3.6            sass_0.4.9              digest_0.6.37          
## [70] SparseArray_1.6.0       htmlwidgets_1.6.4       htmltools_0.5.8.1      
## [73] lifecycle_1.0.4         httr_1.4.7              statmod_1.5.0          
## [76] mime_0.12

END of report