Mitch Report

date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     stat
## 0610009B22Rik -0.5935749
## 0610009L18Rik  0.2161104
## 0610010K14Rik -0.1134635
## 0610012G03Rik -0.3269221
## 0610030E20Rik -0.0645616
## 0610040J01Rik -1.2938364

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	674
num_genes_in_profile	9471
duplicated_genes_present	0
num_profile_genes_in_sets	2778
num_profile_genes_not_in_sets	6693

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	674
num_genesets_excluded	209
num_genesets_included	465

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	8.40e-09	-0.960	4.88e-07
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	8.92e-12	-0.904	6.91e-10
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	3.80e-32	-0.887	5.88e-30
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	1.69e-37	-0.865	3.93e-35
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	6.57e-50	-0.829	3.06e-47
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	4.27e-16	-0.762	4.97e-14
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	3.07e-06	-0.747	1.19e-04
REACTOME NCAM1 INTERACTIONS	16	1.86e-06	0.688	8.65e-05
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	1.12e-04	-0.673	3.06e-03
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	2.51e-13	-0.653	2.33e-11
REACTOME PYRUVATE METABOLISM	16	2.31e-05	-0.611	8.25e-04
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	36	3.25e-10	0.605	2.16e-08
REACTOME COLLAGEN FORMATION	31	2.49e-08	0.579	1.28e-06
REACTOME COMPLEMENT CASCADE	11	2.66e-03	0.523	3.86e-02
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	10	4.58e-03	-0.518	5.76e-02
REACTOME ADP SIGNALLING THROUGH P2RY1	12	2.32e-03	-0.508	3.60e-02
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	7.89e-04	-0.485	1.67e-02
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	7.67e-03	0.464	9.15e-02
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	11	8.14e-03	-0.461	9.27e-02
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	11	8.42e-03	-0.459	9.32e-02
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	12	6.02e-03	-0.458	7.37e-02
REACTOME KERATAN SULFATE KERATIN METABOLISM	15	3.41e-03	0.437	4.76e-02
REACTOME KERATAN SULFATE BIOSYNTHESIS	12	9.39e-03	0.433	1.01e-01
REACTOME ADP SIGNALLING THROUGH P2RY12	10	1.88e-02	-0.429	1.71e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	22	1.28e-03	-0.397	2.29e-02
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	22	1.28e-03	-0.397	2.29e-02
REACTOME HS GAG DEGRADATION	10	3.23e-02	0.391	2.78e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING	13	1.51e-02	-0.389	1.46e-01
REACTOME SIGNAL AMPLIFICATION	15	1.16e-02	-0.377	1.15e-01
REACTOME G PROTEIN ACTIVATION	11	3.14e-02	-0.375	2.76e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	17	1.13e-02	-0.355	1.14e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM	48	4.06e-05	0.343	1.26e-03
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	11	5.05e-02	-0.341	3.55e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	35	8.77e-04	0.325	1.77e-02
REACTOME MYOGENESIS	22	1.01e-02	0.317	1.07e-01
REACTOME SIGNALING BY NODAL	11	7.95e-02	0.305	4.40e-01
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	83	2.08e-06	-0.302	8.77e-05
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	21	1.80e-02	0.298	1.67e-01
REACTOME METABOLISM OF PORPHYRINS	11	8.70e-02	-0.298	4.60e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	13	6.72e-02	0.293	4.05e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	23	1.61e-02	0.290	1.53e-01
REACTOME SIGNALING BY NOTCH3	11	1.00e-01	-0.286	4.71e-01
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	14	6.55e-02	-0.284	4.05e-01
REACTOME LIPOPROTEIN METABOLISM	11	1.05e-01	0.282	4.88e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	17	4.76e-02	-0.278	3.51e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	13	8.42e-02	0.277	4.55e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS	15	6.49e-02	0.275	4.05e-01
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	10	1.32e-01	0.275	5.59e-01
REACTOME SYNTHESIS OF PA	11	1.25e-01	-0.267	5.37e-01
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	13	9.55e-02	-0.267	4.66e-01

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	8.40e-09	-0.960000	4.88e-07
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	8.92e-12	-0.904000	6.91e-10
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	3.80e-32	-0.887000	5.88e-30
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	1.69e-37	-0.865000	3.93e-35
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	6.57e-50	-0.829000	3.06e-47
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	4.27e-16	-0.762000	4.97e-14
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	3.07e-06	-0.747000	1.19e-04
REACTOME NCAM1 INTERACTIONS	16	1.86e-06	0.688000	8.65e-05
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	1.12e-04	-0.673000	3.06e-03
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	2.51e-13	-0.653000	2.33e-11
REACTOME PYRUVATE METABOLISM	16	2.31e-05	-0.611000	8.25e-04
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	36	3.25e-10	0.605000	2.16e-08
REACTOME COLLAGEN FORMATION	31	2.49e-08	0.579000	1.28e-06
REACTOME COMPLEMENT CASCADE	11	2.66e-03	0.523000	3.86e-02
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	10	4.58e-03	-0.518000	5.76e-02
REACTOME ADP SIGNALLING THROUGH P2RY1	12	2.32e-03	-0.508000	3.60e-02
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	7.89e-04	-0.485000	1.67e-02
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	7.67e-03	0.464000	9.15e-02
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	11	8.14e-03	-0.461000	9.27e-02
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	11	8.42e-03	-0.459000	9.32e-02
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	12	6.02e-03	-0.458000	7.37e-02
REACTOME KERATAN SULFATE KERATIN METABOLISM	15	3.41e-03	0.437000	4.76e-02
REACTOME KERATAN SULFATE BIOSYNTHESIS	12	9.39e-03	0.433000	1.01e-01
REACTOME ADP SIGNALLING THROUGH P2RY12	10	1.88e-02	-0.429000	1.71e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	22	1.28e-03	-0.397000	2.29e-02
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	22	1.28e-03	-0.397000	2.29e-02
REACTOME HS GAG DEGRADATION	10	3.23e-02	0.391000	2.78e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING	13	1.51e-02	-0.389000	1.46e-01
REACTOME SIGNAL AMPLIFICATION	15	1.16e-02	-0.377000	1.15e-01
REACTOME G PROTEIN ACTIVATION	11	3.14e-02	-0.375000	2.76e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	17	1.13e-02	-0.355000	1.14e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM	48	4.06e-05	0.343000	1.26e-03
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	11	5.05e-02	-0.341000	3.55e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	35	8.77e-04	0.325000	1.77e-02
REACTOME MYOGENESIS	22	1.01e-02	0.317000	1.07e-01
REACTOME SIGNALING BY NODAL	11	7.95e-02	0.305000	4.40e-01
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	83	2.08e-06	-0.302000	8.77e-05
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	21	1.80e-02	0.298000	1.67e-01
REACTOME METABOLISM OF PORPHYRINS	11	8.70e-02	-0.298000	4.60e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	13	6.72e-02	0.293000	4.05e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	23	1.61e-02	0.290000	1.53e-01
REACTOME SIGNALING BY NOTCH3	11	1.00e-01	-0.286000	4.71e-01
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	14	6.55e-02	-0.284000	4.05e-01
REACTOME LIPOPROTEIN METABOLISM	11	1.05e-01	0.282000	4.88e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	17	4.76e-02	-0.278000	3.51e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	13	8.42e-02	0.277000	4.55e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS	15	6.49e-02	0.275000	4.05e-01
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	10	1.32e-01	0.275000	5.59e-01
REACTOME SYNTHESIS OF PA	11	1.25e-01	-0.267000	5.37e-01
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	13	9.55e-02	-0.267000	4.66e-01
REACTOME PEPTIDE CHAIN ELONGATION	67	1.84e-04	-0.265000	4.51e-03
REACTOME VIRAL MESSENGER RNA SYNTHESIS	14	9.73e-02	-0.256000	4.66e-01
REACTOME GABA B RECEPTOR ACTIVATION	15	8.84e-02	-0.254000	4.62e-01
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	23	3.88e-02	0.249000	3.10e-01
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	20	5.77e-02	-0.245000	3.78e-01
REACTOME GLUCONEOGENESIS	18	7.35e-02	-0.244000	4.18e-01
REACTOME HS GAG BIOSYNTHESIS	14	1.16e-01	0.243000	5.13e-01
REACTOME STRIATED MUSCLE CONTRACTION	25	3.60e-02	-0.243000	3.02e-01
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	86	1.23e-04	-0.240000	3.17e-03
REACTOME GABA RECEPTOR ACTIVATION	16	9.69e-02	-0.240000	4.66e-01
REACTOME G ALPHA Z SIGNALLING EVENTS	22	5.29e-02	-0.239000	3.62e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	22	5.47e-02	-0.237000	3.64e-01
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	23	5.01e-02	0.236000	3.55e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	13	1.45e-01	-0.234000	5.77e-01
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	16	1.14e-01	0.228000	5.13e-01
REACTOME SIGNAL ATTENUATION	10	2.12e-01	0.228000	6.92e-01
REACTOME INWARDLY RECTIFYING K CHANNELS	11	1.91e-01	-0.228000	6.68e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS	10	2.16e-01	0.226000	6.92e-01
REACTOME PEROXISOMAL LIPID METABOLISM	16	1.18e-01	-0.226000	5.17e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	43	1.05e-02	0.226000	1.09e-01
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	18	9.98e-02	0.224000	4.71e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	14	1.49e-01	-0.223000	5.77e-01
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	19	9.43e-02	-0.222000	4.66e-01
REACTOME EGFR DOWNREGULATION	23	6.60e-02	0.222000	4.05e-01
REACTOME PLATELET HOMEOSTASIS	34	2.70e-02	-0.219000	2.41e-01
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	89	3.77e-04	-0.219000	8.78e-03
REACTOME MHC CLASS II ANTIGEN PRESENTATION	60	3.48e-03	0.218000	4.76e-02
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	85	6.17e-04	-0.215000	1.37e-02
REACTOME NEPHRIN INTERACTIONS	15	1.54e-01	-0.213000	5.77e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	22	8.60e-02	0.212000	4.60e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	32	3.94e-02	0.211000	3.10e-01
REACTOME SIGNALING BY NOTCH2	11	2.29e-01	-0.209000	7.15e-01
REACTOME LYSOSOME VESICLE BIOGENESIS	17	1.51e-01	0.201000	5.77e-01
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	16	1.67e-01	-0.199000	6.08e-01
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	19	1.34e-01	-0.199000	5.59e-01
REACTOME DESTABILIZATION OF MRNA BY KSRP	14	2.08e-01	-0.194000	6.86e-01
REACTOME METAL ION SLC TRANSPORTERS	12	2.44e-01	-0.194000	7.38e-01
REACTOME CELL CELL JUNCTION ORGANIZATION	13	2.34e-01	0.191000	7.25e-01
REACTOME DOUBLE STRAND BREAK REPAIR	12	2.55e-01	0.190000	7.56e-01
REACTOME SIGNALING BY NOTCH4	11	2.77e-01	-0.189000	7.79e-01
REACTOME G ALPHA S SIGNALLING EVENTS	30	7.47e-02	-0.188000	4.18e-01
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	16	1.93e-01	-0.188000	6.68e-01
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	42	3.79e-02	-0.185000	3.09e-01
REACTOME G ALPHA I SIGNALLING EVENTS	30	8.04e-02	-0.185000	4.40e-01
REACTOME SIGNALING BY ROBO RECEPTOR	19	1.64e-01	0.185000	6.05e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	28	9.26e-02	0.184000	4.63e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	10	3.19e-01	-0.182000	7.91e-01
REACTOME CHOLESTEROL BIOSYNTHESIS	12	2.78e-01	-0.181000	7.79e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	22	1.42e-01	0.181000	5.77e-01
REACTOME CIRCADIAN CLOCK	42	4.70e-02	0.177000	3.51e-01
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	38	6.15e-02	0.175000	3.97e-01
REACTOME TIE2 SIGNALING	13	2.74e-01	-0.175000	7.79e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	31	9.21e-02	0.175000	4.63e-01
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	10	3.47e-01	-0.172000	8.16e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS	37	7.28e-02	-0.171000	4.18e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	13	2.87e-01	-0.171000	7.81e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	15	2.54e-01	-0.170000	7.56e-01
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	49	4.02e-02	-0.170000	3.12e-01
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	18	2.25e-01	0.165000	7.15e-01
REACTOME INFLUENZA LIFE CYCLE	113	2.63e-03	-0.164000	3.86e-02
REACTOME INTERFERON GAMMA SIGNALING	24	1.65e-01	0.164000	6.06e-01
REACTOME MRNA CAPPING	28	1.35e-01	-0.163000	5.59e-01
REACTOME TRANSLATION	124	1.79e-03	-0.163000	2.97e-02
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	28	1.38e-01	-0.162000	5.68e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	105	4.55e-03	-0.161000	5.76e-02
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	13	3.16e-01	-0.161000	7.91e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	43	6.89e-02	-0.161000	4.05e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	11	3.59e-01	0.160000	8.16e-01
REACTOME BIOLOGICAL OXIDATIONS	38	8.94e-02	-0.159000	4.62e-01
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	13	3.20e-01	-0.159000	7.91e-01
REACTOME APOPTOTIC EXECUTION PHASE	28	1.45e-01	0.159000	5.77e-01
REACTOME AXON GUIDANCE	142	1.13e-03	0.159000	2.18e-02
REACTOME DEVELOPMENTAL BIOLOGY	238	3.00e-05	0.158000	9.97e-04
REACTOME METABOLISM OF CARBOHYDRATES	129	2.08e-03	0.158000	3.33e-02
REACTOME G ALPHA Q SIGNALLING EVENTS	43	7.43e-02	-0.158000	4.18e-01
REACTOME POTASSIUM CHANNELS	23	1.95e-01	-0.156000	6.68e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS	12	3.50e-01	0.156000	8.16e-01
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	22	2.06e-01	0.156000	6.86e-01
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	15	3.01e-01	0.154000	7.85e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	47	6.78e-02	0.154000	4.05e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	16	2.86e-01	-0.154000	7.81e-01
REACTOME P38MAPK EVENTS	10	4.05e-01	-0.152000	8.60e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	15	3.10e-01	0.151000	7.91e-01
REACTOME DESTABILIZATION OF MRNA BY BRF1	16	2.99e-01	-0.150000	7.85e-01
REACTOME NUCLEAR SIGNALING BY ERBB4	22	2.26e-01	-0.149000	7.15e-01
REACTOME PLATELET SENSITIZATION BY LDL	11	3.92e-01	-0.149000	8.46e-01
REACTOME SPHINGOLIPID METABOLISM	34	1.34e-01	0.149000	5.59e-01
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	16	3.08e-01	-0.147000	7.91e-01
REACTOME GLYCOSPHINGOLIPID METABOLISM	19	2.70e-01	0.146000	7.79e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	10	4.25e-01	0.146000	8.72e-01
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	18	2.86e-01	0.145000	7.81e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	14	3.53e-01	0.143000	8.16e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI	14	3.55e-01	0.143000	8.16e-01
REACTOME GENERIC TRANSCRIPTION PATHWAY	136	4.26e-03	0.143000	5.66e-02
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	10	4.36e-01	-0.142000	8.73e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	11	4.17e-01	0.141000	8.62e-01
REACTOME GPCR LIGAND BINDING	42	1.15e-01	-0.141000	5.13e-01
REACTOME METABOLISM OF MRNA	177	1.34e-03	-0.140000	2.31e-02
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	33	1.63e-01	0.140000	6.05e-01
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	20	2.80e-01	0.140000	7.79e-01
REACTOME MICRORNA MIRNA BIOGENESIS	18	3.07e-01	-0.139000	7.91e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	17	3.23e-01	0.138000	7.91e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	10	4.50e-01	-0.138000	8.82e-01
REACTOME METABOLISM OF POLYAMINES	12	4.08e-01	-0.138000	8.62e-01
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	16	3.43e-01	-0.137000	8.16e-01
REACTOME DOWNSTREAM TCR SIGNALING	20	2.91e-01	-0.136000	7.83e-01
REACTOME METABOLISM OF PROTEINS	303	5.33e-05	-0.136000	1.55e-03
REACTOME G2 M CHECKPOINTS	18	3.22e-01	0.135000	7.91e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION	19	3.10e-01	0.135000	7.91e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	21	2.99e-01	0.131000	7.85e-01
REACTOME SIGNALING BY PDGF	86	3.63e-02	0.131000	3.02e-01
REACTOME SIGNALING BY NOTCH	74	5.44e-02	0.130000	3.64e-01
REACTOME INTERFERON SIGNALING	77	5.04e-02	0.129000	3.55e-01
REACTOME GLUCOSE TRANSPORT	29	2.29e-01	0.129000	7.15e-01
REACTOME PURINE METABOLISM	25	2.65e-01	-0.129000	7.75e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	17	3.58e-01	-0.129000	8.16e-01
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	17	3.60e-01	-0.128000	8.16e-01
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	17	3.60e-01	-0.128000	8.16e-01
REACTOME SIGNAL TRANSDUCTION BY L1	28	2.41e-01	0.128000	7.38e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	11	4.65e-01	-0.127000	8.94e-01
REACTOME SIGNALING BY NOTCH1	50	1.24e-01	0.126000	5.37e-01
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	11	4.71e-01	0.126000	8.94e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	11	4.71e-01	-0.126000	8.94e-01
REACTOME RNA POL III TRANSCRIPTION TERMINATION	18	3.61e-01	-0.125000	8.16e-01
REACTOME MUSCLE CONTRACTION	40	1.80e-01	-0.123000	6.45e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	64	9.22e-02	0.122000	4.63e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS	14	4.36e-01	0.120000	8.73e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	23	3.20e-01	-0.120000	7.91e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	4.56e-01	0.119000	8.83e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	31	2.50e-01	0.119000	7.51e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	61	1.08e-01	-0.119000	4.96e-01
REACTOME DIABETES PATHWAYS	91	5.23e-02	0.118000	3.62e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	50	1.53e-01	0.117000	5.77e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	27	2.97e-01	0.116000	7.85e-01
REACTOME RNA POL I TRANSCRIPTION TERMINATION	19	3.83e-01	-0.116000	8.44e-01
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	45	1.86e-01	-0.114000	6.61e-01
REACTOME SHC MEDIATED CASCADE	10	5.44e-01	0.111000	9.06e-01
REACTOME REGULATION OF INSULIN SECRETION	39	2.36e-01	-0.110000	7.25e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	43	2.15e-01	0.110000	6.92e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	20	4.00e-01	0.109000	8.54e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE	17	4.39e-01	0.108000	8.73e-01
REACTOME METABOLISM OF NUCLEOTIDES	46	2.08e-01	-0.107000	6.86e-01
REACTOME TOLL RECEPTOR CASCADES	74	1.14e-01	0.107000	5.13e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	20	4.11e-01	-0.106000	8.62e-01
REACTOME CTLA4 INHIBITORY SIGNALING	15	4.78e-01	-0.106000	8.96e-01
REACTOME METABOLISM OF RNA	214	8.17e-03	-0.106000	9.27e-02
REACTOME MITOTIC G2 G2 M PHASES	49	2.02e-01	0.105000	6.86e-01
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	11	5.45e-01	-0.105000	9.06e-01
REACTOME TELOMERE MAINTENANCE	19	4.27e-01	-0.105000	8.72e-01
REACTOME OPIOID SIGNALLING	41	2.45e-01	-0.105000	7.38e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES	18	4.45e-01	-0.104000	8.78e-01
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	38	2.78e-01	0.102000	7.79e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	24	3.90e-01	-0.102000	8.46e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	51	2.14e-01	0.101000	6.92e-01
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	37	2.91e-01	-0.101000	7.83e-01
REACTOME MEIOSIS	24	3.95e-01	0.100000	8.46e-01
REACTOME ION CHANNEL TRANSPORT	19	4.51e-01	-0.099900	8.82e-01
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	58	1.93e-01	0.099000	6.68e-01
REACTOME IL 3 5 AND GM CSF SIGNALING	25	3.92e-01	-0.098900	8.46e-01
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	21	4.38e-01	0.097800	8.73e-01
REACTOME MTORC1 MEDIATED SIGNALLING	11	5.76e-01	-0.097500	9.08e-01
REACTOME INNATE IMMUNE SYSTEM	120	6.80e-02	0.096800	4.05e-01
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	12	5.62e-01	-0.096600	9.08e-01
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	19	4.67e-01	-0.096300	8.94e-01
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	13	5.49e-01	0.096100	9.06e-01
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	18	4.83e-01	-0.095500	8.99e-01
REACTOME EXTENSION OF TELOMERES	15	5.23e-01	-0.095300	9.06e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	18	4.87e-01	0.094600	8.99e-01
REACTOME ACTIVATION OF GENES BY ATF4	18	4.95e-01	-0.093000	9.06e-01
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	35	3.50e-01	-0.091300	8.16e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	26	4.21e-01	0.091300	8.66e-01
REACTOME UNFOLDED PROTEIN RESPONSE	64	2.08e-01	0.091200	6.86e-01
REACTOME DAG AND IP3 SIGNALING	16	5.31e-01	0.090500	9.06e-01
REACTOME SEMAPHORIN INTERACTIONS	41	3.17e-01	0.090400	7.91e-01
REACTOME G0 AND EARLY G1	12	5.88e-01	0.090400	9.08e-01
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	10	6.21e-01	-0.090200	9.11e-01
REACTOME SIGNALING BY HIPPO	16	5.33e-01	0.090100	9.06e-01
REACTOME LATE PHASE OF HIV LIFE CYCLE	85	1.52e-01	0.090000	5.77e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	11	6.08e-01	-0.089300	9.09e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	72	1.95e-01	-0.088500	6.68e-01
REACTOME G1 PHASE	25	4.45e-01	0.088200	8.78e-01
REACTOME L1CAM INTERACTIONS	51	2.77e-01	0.088200	7.79e-01
REACTOME PHASE II CONJUGATION	24	4.67e-01	-0.085900	8.94e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	16	5.52e-01	0.085900	9.06e-01
REACTOME MRNA SPLICING MINOR PATHWAY	38	3.62e-01	-0.085600	8.16e-01
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	14	5.81e-01	0.085300	9.08e-01
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	28	4.37e-01	0.085000	8.73e-01
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	17	5.45e-01	-0.084800	9.06e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	14	5.83e-01	-0.084700	9.08e-01
REACTOME IL1 SIGNALING	26	4.56e-01	0.084500	8.83e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	54	2.84e-01	0.084500	7.81e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	100	1.47e-01	0.084100	5.77e-01
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	19	5.26e-01	-0.084100	9.06e-01
REACTOME ELONGATION ARREST AND RECOVERY	24	4.78e-01	-0.083700	8.96e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	16	5.63e-01	0.083500	9.08e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	22	5.04e-01	-0.082400	9.06e-01
REACTOME PI3K CASCADE	45	3.45e-01	0.081500	8.16e-01
REACTOME HIV LIFE CYCLE	93	1.77e-01	0.081200	6.39e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	5.99e-01	0.081100	9.09e-01
REACTOME GLYCOLYSIS	19	5.44e-01	0.080500	9.06e-01
REACTOME DEADENYLATION OF MRNA	16	5.78e-01	-0.080300	9.08e-01
REACTOME INTERFERON ALPHA BETA SIGNALING	15	5.95e-01	0.079300	9.08e-01
REACTOME SMOOTH MUSCLE CONTRACTION	19	5.52e-01	-0.078800	9.06e-01
REACTOME RAP1 SIGNALLING	12	6.37e-01	-0.078600	9.11e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	59	2.98e-01	0.078500	7.85e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	12	6.39e-01	-0.078200	9.11e-01
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	42	3.83e-01	-0.078000	8.44e-01
REACTOME RNA POL III CHAIN ELONGATION	16	5.95e-01	-0.076700	9.08e-01
REACTOME ENOS ACTIVATION AND REGULATION	12	6.51e-01	-0.075400	9.14e-01
REACTOME SHC RELATED EVENTS	14	6.27e-01	0.075100	9.11e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	17	5.94e-01	-0.074700	9.08e-01
REACTOME SIGNALING BY BMP	17	6.02e-01	0.073100	9.09e-01
REACTOME CALNEXIN CALRETICULIN CYCLE	11	6.75e-01	0.073000	9.14e-01
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	51	3.72e-01	-0.072300	8.31e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	64	3.19e-01	-0.072100	7.91e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	24	5.42e-01	-0.071900	9.06e-01
REACTOME SHC MEDIATED SIGNALLING	13	6.56e-01	0.071400	9.14e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	10	6.97e-01	-0.071100	9.24e-01
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	53	3.73e-01	-0.070800	8.31e-01
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	11	6.88e-01	0.070000	9.22e-01
REACTOME REGULATION OF SIGNALING BY CBL	14	6.51e-01	-0.069800	9.14e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	144	1.53e-01	0.069300	5.77e-01
REACTOME NEURONAL SYSTEM	89	2.60e-01	-0.069200	7.66e-01
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	24	5.60e-01	-0.068800	9.08e-01
REACTOME REGULATION OF MITOTIC CELL CYCLE	60	3.59e-01	-0.068500	8.16e-01
REACTOME SIGNALLING BY NGF	152	1.47e-01	0.068400	5.77e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	14	6.60e-01	0.068000	9.14e-01
REACTOME NOD1 2 SIGNALING PATHWAY	17	6.35e-01	-0.066500	9.11e-01
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	17	6.36e-01	0.066300	9.11e-01
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	21	6.00e-01	0.066200	9.09e-01
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	56	3.95e-01	-0.065900	8.46e-01
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	18	6.30e-01	0.065700	9.11e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	5.95e-01	0.065500	9.08e-01
REACTOME PERK REGULATED GENE EXPRESSION	21	6.08e-01	-0.064600	9.09e-01
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	50	4.31e-01	0.064500	8.73e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	28	5.55e-01	0.064500	9.06e-01
REACTOME MEIOTIC SYNAPSIS	15	6.66e-01	0.064400	9.14e-01
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	101	2.72e-01	0.063400	7.79e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	10	7.29e-01	-0.063400	9.31e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	17	6.53e-01	0.063000	9.14e-01
REACTOME BASE EXCISION REPAIR	12	7.06e-01	0.063000	9.25e-01
REACTOME PIP3 ACTIVATES AKT SIGNALING	25	5.86e-01	-0.062900	9.08e-01
REACTOME IL RECEPTOR SHC SIGNALING	15	6.75e-01	-0.062600	9.14e-01
REACTOME CELL JUNCTION ORGANIZATION	27	5.76e-01	0.062200	9.08e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	6.31e-01	-0.062100	9.11e-01
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	81	3.39e-01	-0.061600	8.16e-01
REACTOME METABOLISM OF NON CODING RNA	40	5.03e-01	0.061200	9.06e-01
REACTOME SIGNALING BY EGFR IN CANCER	83	3.42e-01	0.060500	8.16e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	13	7.06e-01	0.060400	9.25e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	24	6.10e-01	0.060300	9.09e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	15	6.95e-01	-0.058500	9.23e-01
REACTOME SIGNALING BY ERBB4	67	4.14e-01	-0.057900	8.62e-01
REACTOME IRON UPTAKE AND TRANSPORT	23	6.32e-01	-0.057700	9.11e-01
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	42	5.22e-01	-0.057200	9.06e-01
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	43	5.21e-01	-0.056600	9.06e-01
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	40	5.36e-01	-0.056600	9.06e-01
REACTOME RECYCLING PATHWAY OF L1	19	6.71e-01	0.056300	9.14e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	11	7.47e-01	-0.056100	9.31e-01
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	42	5.34e-01	-0.055500	9.06e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	38	5.55e-01	-0.055400	9.06e-01
REACTOME SIGNALING BY INSULIN RECEPTOR	73	4.17e-01	0.055000	8.62e-01
REACTOME DARPP 32 EVENTS	18	6.89e-01	0.054500	9.22e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	56	4.82e-01	-0.054400	8.99e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	21	6.68e-01	0.054200	9.14e-01
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	36	5.80e-01	-0.053400	9.08e-01
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	16	7.15e-01	0.052800	9.31e-01
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	53	5.07e-01	-0.052800	9.06e-01
REACTOME IMMUNE SYSTEM	513	4.48e-02	0.052600	3.42e-01
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	19	6.92e-01	0.052500	9.22e-01
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	49	5.27e-01	-0.052300	9.06e-01
REACTOME SOS MEDIATED SIGNALLING	13	7.51e-01	0.050800	9.31e-01
REACTOME SIGNALING BY SCF KIT	56	5.13e-01	-0.050600	9.06e-01
REACTOME ER PHAGOSOME PATHWAY	48	5.47e-01	-0.050300	9.06e-01
REACTOME PKB MEDIATED EVENTS	27	6.52e-01	0.050200	9.14e-01
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	48	5.50e-01	-0.050000	9.06e-01
REACTOME DNA REPAIR	67	4.86e-01	0.049300	8.99e-01
REACTOME IL 2 SIGNALING	26	6.65e-01	-0.049200	9.14e-01
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	44	5.73e-01	0.049100	9.08e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	42	5.85e-01	-0.048800	9.08e-01
REACTOME ACTIVATED TLR4 SIGNALLING	60	5.14e-01	0.048700	9.06e-01
REACTOME ERK MAPK TARGETS	18	7.22e-01	0.048500	9.31e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	28	6.60e-01	-0.048000	9.14e-01
REACTOME M G1 TRANSITION	51	5.54e-01	-0.048000	9.06e-01
REACTOME MRNA SPLICING	99	4.17e-01	-0.047300	8.62e-01
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	125	3.65e-01	-0.047100	8.19e-01
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	27	6.76e-01	-0.046500	9.14e-01
REACTOME TRNA AMINOACYLATION	39	6.17e-01	-0.046300	9.11e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	12	7.83e-01	0.046000	9.48e-01
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	17	7.50e-01	0.044700	9.31e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	22	7.18e-01	-0.044500	9.31e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	37	6.52e-01	0.042800	9.14e-01
REACTOME G1 S TRANSITION	68	5.44e-01	-0.042600	9.06e-01
REACTOME SIGNALING BY FGFR1 MUTANTS	19	7.48e-01	0.042600	9.31e-01
REACTOME PI3K AKT ACTIVATION	31	6.90e-01	-0.041400	9.22e-01
REACTOME RNA POL I TRANSCRIPTION INITIATION	23	7.35e-01	-0.040800	9.31e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	51	6.15e-01	0.040700	9.11e-01
REACTOME SIGNALLING TO RAS	20	7.56e-01	-0.040100	9.33e-01
REACTOME CTNNB1 PHOSPHORYLATION CASCADE	14	7.95e-01	0.040000	9.56e-01
REACTOME SIGNALING BY FGFR MUTANTS	26	7.27e-01	0.039600	9.31e-01
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	175	3.86e-01	-0.038200	8.46e-01
REACTOME DNA STRAND ELONGATION	13	8.12e-01	-0.038200	9.57e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	97	5.23e-01	-0.037600	9.06e-01
REACTOME GLUCOSE METABOLISM	43	6.72e-01	-0.037300	9.14e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	97	5.30e-01	0.037000	9.06e-01
REACTOME LAGGING STRAND SYNTHESIS	10	8.42e-01	0.036500	9.67e-01
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	18	7.89e-01	0.036400	9.51e-01
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	57	6.37e-01	0.036200	9.11e-01
REACTOME FRS2 MEDIATED CASCADE	16	8.03e-01	0.036000	9.57e-01
REACTOME REGULATION OF IFNG SIGNALING	10	8.44e-01	0.035900	9.67e-01
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	25	7.59e-01	0.035400	9.34e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	44	6.91e-01	-0.034700	9.22e-01
REACTOME SULFUR AMINO ACID METABOLISM	17	8.06e-01	-0.034400	9.57e-01
REACTOME GAB1 SIGNALOSOME	32	7.37e-01	-0.034300	9.31e-01
REACTOME RNA POL III TRANSCRIPTION	30	7.52e-01	-0.033400	9.31e-01
REACTOME HIV INFECTION	156	4.75e-01	0.033300	8.96e-01
REACTOME CD28 CO STIMULATION	22	7.88e-01	-0.033200	9.51e-01
REACTOME INSULIN RECEPTOR RECYCLING	15	8.26e-01	-0.032800	9.58e-01
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	17	8.17e-01	-0.032400	9.58e-01
REACTOME PI 3K CASCADE	34	7.45e-01	-0.032200	9.31e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	10	8.60e-01	0.032200	9.71e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	11	8.54e-01	0.032000	9.67e-01
REACTOME INTEGRATION OF ENERGY METABOLISM	62	6.69e-01	-0.031400	9.14e-01
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	10	8.66e-01	0.030700	9.73e-01
REACTOME RNA POL II TRANSCRIPTION	86	6.31e-01	-0.030100	9.11e-01
REACTOME MRNA 3 END PROCESSING	31	7.75e-01	0.029600	9.46e-01
REACTOME PPARA ACTIVATES GENE EXPRESSION	80	6.54e-01	0.029100	9.14e-01
REACTOME PYRIMIDINE METABOLISM	10	8.80e-01	-0.027700	9.74e-01
REACTOME CELL CYCLE	213	4.94e-01	0.027300	9.06e-01
REACTOME TCR SIGNALING	27	8.08e-01	-0.027000	9.57e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	40	7.68e-01	-0.026900	9.43e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	21	8.31e-01	0.026900	9.58e-01
REACTOME REGULATORY RNA PATHWAYS	21	8.33e-01	-0.026600	9.58e-01
REACTOME SIGNALING BY WNT	56	7.31e-01	-0.026600	9.31e-01
REACTOME GPCR DOWNSTREAM SIGNALING	109	6.39e-01	-0.026100	9.11e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN	50	7.51e-01	-0.026000	9.31e-01
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	56	7.37e-01	0.026000	9.31e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	189	5.40e-01	-0.026000	9.06e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	15	8.64e-01	-0.025600	9.73e-01
REACTOME SIGNALING BY ILS	66	7.26e-01	0.025000	9.31e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	164	5.85e-01	-0.024900	9.08e-01
REACTOME PLC BETA MEDIATED EVENTS	20	8.49e-01	0.024600	9.67e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	56	7.53e-01	-0.024400	9.31e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	71	7.24e-01	-0.024300	9.31e-01
REACTOME SIGNALING BY FGFR IN DISEASE	81	7.06e-01	0.024300	9.25e-01
REACTOME CHROMOSOME MAINTENANCE	35	8.12e-01	-0.023300	9.57e-01
REACTOME ERKS ARE INACTIVATED	10	9.01e-01	0.022700	9.74e-01
REACTOME SPRY REGULATION OF FGF SIGNALING	12	8.93e-01	0.022500	9.74e-01
REACTOME PHOSPHORYLATION OF THE APC C	14	8.84e-01	-0.022500	9.74e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	32	8.27e-01	-0.022400	9.58e-01
REACTOME CELL CYCLE MITOTIC	187	6.06e-01	0.022000	9.09e-01
REACTOME SIGNALING BY RHO GTPASES	61	7.75e-01	0.021200	9.46e-01
REACTOME MITOTIC M M G1 PHASES	94	7.24e-01	-0.021100	9.31e-01
REACTOME RNA POL I TRANSCRIPTION	26	8.52e-01	-0.021100	9.67e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS	97	7.21e-01	0.021100	9.31e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	48	8.05e-01	0.020700	9.57e-01
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	19	8.77e-01	-0.020500	9.74e-01
REACTOME PHOSPHOLIPID METABOLISM	114	7.06e-01	-0.020500	9.25e-01
REACTOME PI METABOLISM	38	8.29e-01	-0.020300	9.58e-01
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	276	5.75e-01	-0.019800	9.08e-01
REACTOME SIGNALING BY ERBB2	68	7.79e-01	0.019700	9.47e-01
REACTOME GLOBAL GENOMIC NER GG NER	23	8.75e-01	0.019000	9.74e-01
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	45	8.27e-01	-0.018800	9.58e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS	16	8.98e-01	0.018400	9.74e-01
REACTOME CELL CYCLE CHECKPOINTS	78	7.80e-01	0.018300	9.47e-01
REACTOME ADAPTIVE IMMUNE SYSTEM	337	5.68e-01	0.018300	9.08e-01
REACTOME BASIGIN INTERACTIONS	14	9.13e-01	0.016900	9.74e-01
REACTOME G ALPHA1213 SIGNALLING EVENTS	43	8.52e-01	-0.016500	9.67e-01
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	43	8.54e-01	-0.016300	9.67e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	60	8.29e-01	0.016100	9.58e-01
REACTOME SIGNALING BY FGFR	69	8.27e-01	0.015300	9.58e-01
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	20	9.07e-01	-0.015100	9.74e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	24	8.98e-01	0.015100	9.74e-01
REACTOME MEMBRANE TRAFFICKING	94	8.02e-01	0.015000	9.57e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	12	9.28e-01	-0.015000	9.74e-01
REACTOME GLUTATHIONE CONJUGATION	13	9.27e-01	-0.014700	9.74e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	17	9.25e-01	-0.013100	9.74e-01
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	50	8.73e-01	-0.013100	9.74e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	21	9.18e-01	0.013100	9.74e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	16	9.31e-01	0.012500	9.75e-01
REACTOME SYNTHESIS OF DNA	61	8.70e-01	-0.012100	9.74e-01
REACTOME NUCLEOTIDE EXCISION REPAIR	39	8.96e-01	-0.012100	9.74e-01
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	46	8.88e-01	-0.012000	9.74e-01
REACTOME SIGNALLING TO ERKS	28	9.16e-01	-0.011500	9.74e-01
REACTOME SIGNALING BY GPCR	150	8.13e-01	-0.011200	9.57e-01
REACTOME REGULATION OF APOPTOSIS	48	8.93e-01	-0.011200	9.74e-01
REACTOME TRANSCRIPTION COUPLED NER TC NER	36	9.13e-01	-0.010500	9.74e-01
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	13	9.48e-01	-0.010500	9.82e-01
REACTOME TRIF MEDIATED TLR3 SIGNALING	52	9.00e-01	0.010100	9.74e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	16	9.47e-01	-0.009650	9.82e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS	20	9.41e-01	0.009620	9.79e-01
REACTOME PROTEIN FOLDING	40	9.22e-01	-0.008950	9.74e-01
REACTOME S PHASE	71	8.99e-01	0.008770	9.74e-01
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	50	9.17e-01	-0.008530	9.74e-01
REACTOME CELL CELL COMMUNICATION	51	9.19e-01	0.008210	9.74e-01
REACTOME DNA REPLICATION	105	8.98e-01	-0.007260	9.74e-01
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	37	9.42e-01	-0.006980	9.79e-01
REACTOME CA DEPENDENT EVENTS	14	9.66e-01	-0.006600	9.85e-01
REACTOME BOTULINUM NEUROTOXICITY	10	9.71e-01	-0.006550	9.85e-01
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	10	9.71e-01	-0.006550	9.85e-01
REACTOME ARMS MEDIATED ACTIVATION	14	9.67e-01	-0.006310	9.85e-01
REACTOME INSULIN SYNTHESIS AND PROCESSING	13	9.72e-01	-0.005690	9.85e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	113	9.23e-01	-0.005260	9.74e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY	34	9.60e-01	-0.004940	9.85e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	124	9.39e-01	0.004000	9.79e-01
REACTOME HEMOSTASIS	221	9.24e-01	-0.003740	9.74e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	12	9.82e-01	-0.003720	9.87e-01
REACTOME NETRIN1 SIGNALING	22	9.79e-01	-0.003210	9.87e-01
REACTOME APOPTOSIS	97	9.57e-01	0.003200	9.85e-01
REACTOME MITOTIC PROMETAPHASE	42	9.73e-01	-0.002990	9.85e-01
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	55	9.70e-01	-0.002970	9.85e-01
REACTOME TRANSCRIPTION	126	9.68e-01	-0.002110	9.85e-01
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	41	9.83e-01	0.001910	9.87e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	16	9.91e-01	0.001590	9.93e-01
REACTOME MRNA PROCESSING	138	9.75e-01	-0.001580	9.85e-01
REACTOME MITOTIC G1 G1 S PHASES	84	9.95e-01	-0.000368	9.95e-01

Detailed Gene set reports

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
	408
set	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
setSize	12
pANOVA	8.4e-09
s.dist	-0.96
p.adjustANOVA	4.88e-07

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp5j2	-4576
Atp5j	-4572
Atp5l	-4558
Atp5h	-4557
Atp5g1	-4552
Atp5k	-4548
Atp5o	-4523
Atp5a1	-4476
Atp5b	-4473
Atp5e	-4376
Atp5c1	-4340
Atp5d	-3789

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp5j2	-4576
Atp5j	-4572
Atp5l	-4558
Atp5h	-4557
Atp5g1	-4552
Atp5k	-4548
Atp5o	-4523
Atp5a1	-4476
Atp5b	-4473
Atp5e	-4376
Atp5c1	-4340
Atp5d	-3789

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
	219
set	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
setSize	19
pANOVA	8.92e-12
s.dist	-0.904
p.adjustANOVA	6.91e-10

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Idh2	-4634
Sdhb	-4602
Idh3b	-4555
Sdha	-4518
Sdhc	-4511
Dld	-4441
Idh3a	-4397
Fh1	-4373
Aco2	-4338
Mdh2	-4292
Sucla2	-4230
Idh3g	-4185
Cs	-4072
Nnt	-4047
Dlst	-3994
Suclg2	-3851
Sdhd	-3737
Ogdh	-3501
Suclg1	-3058

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Idh2	-4634
Sdhb	-4602
Idh3b	-4555
Sdha	-4518
Sdhc	-4511
Dld	-4441
Idh3a	-4397
Fh1	-4373
Aco2	-4338
Mdh2	-4292
Sucla2	-4230
Idh3g	-4185
Cs	-4072
Nnt	-4047
Dlst	-3994
Suclg2	-3851
Sdhd	-3737
Ogdh	-3501
Suclg1	-3058

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
	330
set	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
setSize	59
pANOVA	3.8e-32
s.dist	-0.887
p.adjustANOVA	5.88e-30

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sdhb	-4602
Etfdh	-4591
Ndufab1	-4575
Etfa	-4560
Uqcrc2	-4550
Ndufa4	-4544
Ndufv2	-4538
Uqcr11	-4528
Cox6c	-4525
Ndufa9	-4520
Uqcrfs1	-4519
Sdha	-4518
Sdhc	-4511
Cox5a	-4509
Ndufb9	-4506
Uqcrq	-4504
Cox4i1	-4493
Cox7c	-4477
Ndufa5	-4474
Ndufa1	-4466

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sdhb	-4602
Etfdh	-4591
Ndufab1	-4575
Etfa	-4560
Uqcrc2	-4550
Ndufa4	-4544
Ndufv2	-4538
Uqcr11	-4528
Cox6c	-4525
Ndufa9	-4520
Uqcrfs1	-4519
Sdha	-4518
Sdhc	-4511
Cox5a	-4509
Ndufb9	-4506
Uqcrq	-4504
Cox4i1	-4493
Cox7c	-4477
Ndufa5	-4474
Ndufa1	-4466
Ndufa6	-4461
Ndufs1	-4427
Cyc1	-4425
Ndufb3	-4422
Ndufs8	-4419
Uqcrb	-4416
Etfb	-4402
Cox6b1	-4401
Ndufa12	-4390
Ndufs3	-4368
Uqcrh	-4365
Ndufv1	-4358
Ndufa3	-4353
Uqcrc1	-4347
Ndufa11	-4335
Ndufs2	-4331
Ndufb10	-4324
Ndufs4	-4305
Cox8a	-4260
Ndufb2	-4236
Ndufa2	-4186
Ndufb5	-4163
Ndufa8	-4155
Ndufa10	-4143
Cycs	-4111
Ndufs7	-4107
Ndufv3	-3973
Ndufb4	-3858
Ndufs5	-3797
Sdhd	-3737
Ndufc1	-3608
Ndufc2	-3600
Ndufa13	-3538
Ndufb7	-3465
Ndufa7	-3271
Ndufs6	-3227
Ndufb6	-2575
Cox6a1	-932
Cox7a2l	1697

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
	402
set	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
setSize	73
pANOVA	1.69e-37
s.dist	-0.865
p.adjustANOVA	3.93e-35

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sdhb	-4602
Etfdh	-4591
Atp5j2	-4576
Ndufab1	-4575
Atp5j	-4572
Etfa	-4560
Atp5l	-4558
Atp5h	-4557
Atp5g1	-4552
Uqcrc2	-4550
Atp5k	-4548
Ndufa4	-4544
Ndufv2	-4538
Uqcr11	-4528
Cox6c	-4525
Atp5o	-4523
Ndufa9	-4520
Uqcrfs1	-4519
Sdha	-4518
Sdhc	-4511

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sdhb	-4602
Etfdh	-4591
Atp5j2	-4576
Ndufab1	-4575
Atp5j	-4572
Etfa	-4560
Atp5l	-4558
Atp5h	-4557
Atp5g1	-4552
Uqcrc2	-4550
Atp5k	-4548
Ndufa4	-4544
Ndufv2	-4538
Uqcr11	-4528
Cox6c	-4525
Atp5o	-4523
Ndufa9	-4520
Uqcrfs1	-4519
Sdha	-4518
Sdhc	-4511
Cox5a	-4509
Ndufb9	-4506
Uqcrq	-4504
Cox4i1	-4493
Cox7c	-4477
Atp5a1	-4476
Ndufa5	-4474
Atp5b	-4473
Ndufa1	-4466
Ndufa6	-4461
Ndufs1	-4427
Cyc1	-4425
Ndufb3	-4422
Ndufs8	-4419
Uqcrb	-4416
Etfb	-4402
Cox6b1	-4401
Ndufa12	-4390
Atp5e	-4376
Ndufs3	-4368
Uqcrh	-4365
Ndufv1	-4358
Ndufa3	-4353
Uqcrc1	-4347
Atp5c1	-4340
Ndufa11	-4335
Ndufs2	-4331
Ndufb10	-4324
Ndufs4	-4305
Cox8a	-4260
Ndufb2	-4236
Ndufa2	-4186
Ndufb5	-4163
Ndufa8	-4155
Ndufa10	-4143
Cycs	-4111
Ndufs7	-4107
Ndufv3	-3973
Ndufb4	-3858
Ndufs5	-3797
Atp5d	-3789
Sdhd	-3737
Ndufc1	-3608
Ndufc2	-3600
Ndufa13	-3538
Ndufb7	-3465
Ndufa7	-3271
Ndufs6	-3227
Ndufb6	-2575
Cox6a1	-932
Ucp3	1046
Cox7a2l	1697
Ucp2	3283

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
	24
set	REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
setSize	107
pANOVA	6.57e-50
s.dist	-0.829
p.adjustANOVA	3.06e-47

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ldhb	-4639
Idh2	-4634
Sdhb	-4602
Etfdh	-4591
Atp5j2	-4576
Ndufab1	-4575
Atp5j	-4572
Pdha1	-4571
Etfa	-4560
Slc16a1	-4559
Atp5l	-4558
Atp5h	-4557
Idh3b	-4555
Atp5g1	-4552
Uqcrc2	-4550
Atp5k	-4548
Ndufa4	-4544
Ndufv2	-4538
Pdk4	-4534
Uqcr11	-4528

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ldhb	-4639
Idh2	-4634
Sdhb	-4602
Etfdh	-4591
Atp5j2	-4576
Ndufab1	-4575
Atp5j	-4572
Pdha1	-4571
Etfa	-4560
Slc16a1	-4559
Atp5l	-4558
Atp5h	-4557
Idh3b	-4555
Atp5g1	-4552
Uqcrc2	-4550
Atp5k	-4548
Ndufa4	-4544
Ndufv2	-4538
Pdk4	-4534
Uqcr11	-4528
Cox6c	-4525
Atp5o	-4523
Ndufa9	-4520
Uqcrfs1	-4519
Sdha	-4518
Pdhb	-4517
Sdhc	-4511
Cox5a	-4509
Ndufb9	-4506
Uqcrq	-4504
Cox4i1	-4493
Cox7c	-4477
Atp5a1	-4476
Ndufa5	-4474
Atp5b	-4473
Adhfe1	-4469
Ndufa1	-4466
Ndufa6	-4461
Dlat	-4447
Dld	-4441
Ndufs1	-4427
Cyc1	-4425
Ndufb3	-4422
Ndufs8	-4419
Uqcrb	-4416
Etfb	-4402
Cox6b1	-4401
Idh3a	-4397
Ndufa12	-4390
Atp5e	-4376
Fh1	-4373
Ndufs3	-4368
Uqcrh	-4365
Ndufv1	-4358
Ndufa3	-4353
Uqcrc1	-4347
Atp5c1	-4340
Aco2	-4338
Ndufa11	-4335
Ndufs2	-4331
Ndufb10	-4324
Ndufs4	-4305
Mdh2	-4292
Cox8a	-4260
Pdk1	-4238
Ndufb2	-4236
Sucla2	-4230
Idh1	-4189
Ndufa2	-4186
Idh3g	-4185
Ndufb5	-4163
Ndufa8	-4155
Ndufa10	-4143
Cycs	-4111
Ndufs7	-4107
Cs	-4072
Bsg	-4057
Nnt	-4047
Dlst	-3994
Ndufv3	-3973
D2hgdh	-3892
Ndufb4	-3858
Suclg2	-3851
Pdpr	-3806
Ndufs5	-3797
Atp5d	-3789
Sdhd	-3737
Ndufc1	-3608
Ndufc2	-3600
Ndufa13	-3538
Ogdh	-3501
Ndufb7	-3465
Pdhx	-3346
Ndufa7	-3271
Ndufs6	-3227
Suclg1	-3058
Ndufb6	-2575
Pdk2	-2113
Ldha	-1845
Cox6a1	-932
L2hgdh	-764
Pdp1	-32
Ucp3	1046
Cox7a2l	1697
Pdp2	2090
Ucp2	3283
Slc16a3	4339

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
	5
set	REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
setSize	38
pANOVA	4.27e-16
s.dist	-0.762
p.adjustANOVA	4.97e-14

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ldhb	-4639
Idh2	-4634
Sdhb	-4602
Pdha1	-4571
Slc16a1	-4559
Idh3b	-4555
Pdk4	-4534
Sdha	-4518
Pdhb	-4517
Sdhc	-4511
Adhfe1	-4469
Dlat	-4447
Dld	-4441
Idh3a	-4397
Fh1	-4373
Aco2	-4338
Mdh2	-4292
Pdk1	-4238
Sucla2	-4230
Idh1	-4189

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ldhb	-4639
Idh2	-4634
Sdhb	-4602
Pdha1	-4571
Slc16a1	-4559
Idh3b	-4555
Pdk4	-4534
Sdha	-4518
Pdhb	-4517
Sdhc	-4511
Adhfe1	-4469
Dlat	-4447
Dld	-4441
Idh3a	-4397
Fh1	-4373
Aco2	-4338
Mdh2	-4292
Pdk1	-4238
Sucla2	-4230
Idh1	-4189
Idh3g	-4185
Cs	-4072
Bsg	-4057
Nnt	-4047
Dlst	-3994
D2hgdh	-3892
Suclg2	-3851
Pdpr	-3806
Sdhd	-3737
Ogdh	-3501
Pdhx	-3346
Suclg1	-3058
Pdk2	-2113
Ldha	-1845
L2hgdh	-764
Pdp1	-32
Pdp2	2090
Slc16a3	4339

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
	165
set	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize	13
pANOVA	3.07e-06
s.dist	-0.747
p.adjustANOVA	0.000119

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acadl	-4618
Hadhb	-4599
Hadh	-4586
Hadha	-4574
Acadm	-4568
Acadvl	-4566
Eci1	-4556
Decr1	-4449
Echs1	-4367
Mcee	-3866
Acads	-622
Pcca	-30
Pccb	693

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acadl	-4618
Hadhb	-4599
Hadh	-4586
Hadha	-4574
Acadm	-4568
Acadvl	-4566
Eci1	-4556
Decr1	-4449
Echs1	-4367
Mcee	-3866
Acads	-622
Pcca	-30
Pccb	693

REACTOME_NCAM1_INTERACTIONS

REACTOME_NCAM1_INTERACTIONS
	228
set	REACTOME_NCAM1_INTERACTIONS
setSize	16
pANOVA	1.86e-06
s.dist	0.688
p.adjustANOVA	8.65e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col6a3	4708
Prnp	4699
Col5a1	4634
Col4a1	4287
Agrn	4170
Cacnb1	3757
Col4a2	2288
Gfra1	923
Cacna1s	-2042
Nrtn	-2590

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col6a3	4708
Prnp	4699
Col5a1	4634
Col4a1	4287
Agrn	4170
Cacnb1	3757
Col4a2	2288
Gfra1	923
Cacna1s	-2042
Nrtn	-2590

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
	133
set	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
setSize	11
pANOVA	0.000112
s.dist	-0.673
p.adjustANOVA	0.00306

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdha1	-4571
Pdk4	-4534
Pdhb	-4517
Dlat	-4447
Dld	-4441
Pdk1	-4238
Pdpr	-3806
Pdhx	-3346
Pdk2	-2113
Pdp1	-32
Pdp2	2090

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdha1	-4571
Pdk4	-4534
Pdhb	-4517
Dlat	-4447
Dld	-4441
Pdk1	-4238
Pdpr	-3806
Pdhx	-3346
Pdk2	-2113
Pdp1	-32
Pdp2	2090

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
	62
set	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
setSize	42
pANOVA	2.51e-13
s.dist	-0.653
p.adjustANOVA	2.33e-11

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp5g1	-4552
Hspd1	-4531
Hspa9	-4502
Atp5a1	-4476
Atp5b	-4473
Cyc1	-4425
Slc25a4	-4349
Aco2	-4338
Slc25a12	-4309
Timm8a1	-4258
Timm23	-4227
Hscb	-4203
Samm50	-4188
Idh3g	-4185
Cs	-4072
Ldhd	-4060
Timm9	-4036
Timm44	-4022
Timm10	-4014
Tomm7	-3999

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp5g1	-4552
Hspd1	-4531
Hspa9	-4502
Atp5a1	-4476
Atp5b	-4473
Cyc1	-4425
Slc25a4	-4349
Aco2	-4338
Slc25a12	-4309
Timm8a1	-4258
Timm23	-4227
Hscb	-4203
Samm50	-4188
Idh3g	-4185
Cs	-4072
Ldhd	-4060
Timm9	-4036
Timm44	-4022
Timm10	-4014
Tomm7	-3999
Vdac1	-3998
Mtx2	-3951
Tomm5	-3817
Tomm40	-3803
Pmpcb	-3667
Dnajc19	-3615
Tomm20	-3609
Timm17a	-3442
Pmpca	-3176
Bcs1l	-3170
Grpel2	-3045
Timm8b	-2460
Coq2	-2320
Timm13	-2273
Timm50	-2234
Mtx1	-1486
Grpel1	-1260
Gfer	301
Tomm22	833
Timm22	2548
Timm17b	3654
Fxn	3977

REACTOME_PYRUVATE_METABOLISM

REACTOME_PYRUVATE_METABOLISM
	289
set	REACTOME_PYRUVATE_METABOLISM
setSize	16
pANOVA	2.31e-05
s.dist	-0.611
p.adjustANOVA	0.000825

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ldhb	-4639
Pdha1	-4571
Slc16a1	-4559
Pdk4	-4534
Pdhb	-4517
Dlat	-4447
Dld	-4441
Pdk1	-4238
Bsg	-4057
Pdpr	-3806
Pdhx	-3346
Pdk2	-2113
Ldha	-1845
Pdp1	-32
Pdp2	2090
Slc16a3	4339

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ldhb	-4639
Pdha1	-4571
Slc16a1	-4559
Pdk4	-4534
Pdhb	-4517
Dlat	-4447
Dld	-4441
Pdk1	-4238
Bsg	-4057
Pdpr	-3806
Pdhx	-3346
Pdk2	-2113
Ldha	-1845
Pdp1	-32
Pdp2	2090
Slc16a3	4339

REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
	74
set	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
setSize	36
pANOVA	3.25e-10
s.dist	0.605
p.adjustANOVA	2.16e-08

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col7a1	4790
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col16a1	4757
Col22a1	4719
Col6a3	4708
Col12a1	4657
Col5a1	4634
Col11a2	4528
Timp2	4370
Bmp1	4321
Furin	4298
Col4a1	4287
Col5a3	4268
Mmp14	4243
Pcolce	3629

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col7a1	4790
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col16a1	4757
Col22a1	4719
Col6a3	4708
Col12a1	4657
Col5a1	4634
Col11a2	4528
Timp2	4370
Bmp1	4321
Furin	4298
Col4a1	4287
Col5a3	4268
Mmp14	4243
Pcolce	3629
Pcolce2	3600
Col14a1	3241
Adamts2	3212
Mmp15	3140
Col24a1	2900
Plod2	2796
Mmp2	2599
Col4a2	2288
Plod3	423
P4hb	36
Col8a1	7
Serpinh1	-619
Crtap	-1563
Col15a1	-1839
Ppib	-2286
Plod1	-2654

REACTOME_COLLAGEN_FORMATION

REACTOME_COLLAGEN_FORMATION
	92
set	REACTOME_COLLAGEN_FORMATION
setSize	31
pANOVA	2.49e-08
s.dist	0.579
p.adjustANOVA	1.28e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col7a1	4790
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col16a1	4757
Col22a1	4719
Col6a3	4708
Col12a1	4657
Col5a1	4634
Col11a2	4528
Bmp1	4321
Col4a1	4287
Col5a3	4268
Pcolce	3629
Pcolce2	3600
Col14a1	3241
Adamts2	3212

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col7a1	4790
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col16a1	4757
Col22a1	4719
Col6a3	4708
Col12a1	4657
Col5a1	4634
Col11a2	4528
Bmp1	4321
Col4a1	4287
Col5a3	4268
Pcolce	3629
Pcolce2	3600
Col14a1	3241
Adamts2	3212
Col24a1	2900
Plod2	2796
Col4a2	2288
Plod3	423
P4hb	36
Col8a1	7
Serpinh1	-619
Crtap	-1563
Col15a1	-1839
Ppib	-2286
Plod1	-2654

REACTOME_COMPLEMENT_CASCADE

REACTOME_COMPLEMENT_CASCADE
	427
set	REACTOME_COMPLEMENT_CASCADE
setSize	11
pANOVA	0.00266
s.dist	0.523
p.adjustANOVA	0.0386

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cfd	4826
C3	4781
C1qc	4743
C4b	4660
C1qa	4311
C1qb	3626
C7	2851
Cd46	1283
C1s1	560
Pros1	-1363
Cr1l	-2005

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cfd	4826
C3	4781
C1qc	4743
C4b	4660
C1qa	4311
C1qb	3626
C7	2851
Cd46	1283
C1s1	560
Pros1	-1363
Cr1l	-2005

REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS

REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS
	237
set	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS
setSize	10
pANOVA	0.00458
s.dist	-0.518
p.adjustANOVA	0.0576

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnas	-1499
Gng10	-1227
Gng11	-479
Sctr	-333

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnas	-1499
Gng10	-1227
Gng11	-479
Sctr	-333

REACTOME_ADP_SIGNALLING_THROUGH_P2RY1

REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
	244
set	REACTOME_ADP_SIGNALLING_THROUGH_P2RY1
setSize	12
pANOVA	0.00232
s.dist	-0.508
p.adjustANOVA	0.036

Top enriched genes

Top 20 genes
GeneID	Gene Rank
P2ry1	-4535
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Gng10	-1227
Gng11	-479
Mapk14	-275
Gna11	1614

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
P2ry1	-4535
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Gng10	-1227
Gng11	-479
Mapk14	-275
Gna11	1614

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
	269
set	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
setSize	16
pANOVA	0.000789
s.dist	-0.485
p.adjustANOVA	0.0167

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acat1	-4597
Dld	-4441
Hibch	-4304
Hibadh	-4200
Ivd	-3944
Bckdha	-3936
Aldh6a1	-3923
Mccc1	-3204
Hsd17b10	-2811
Mccc2	-2576
Acad8	-2258
Acadsb	-1619
Dbt	-190
Bcat2	1493
Bckdhb	2175
Auh	3182

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acat1	-4597
Dld	-4441
Hibch	-4304
Hibadh	-4200
Ivd	-3944
Bckdha	-3936
Aldh6a1	-3923
Mccc1	-3204
Hsd17b10	-2811
Mccc2	-2576
Acad8	-2258
Acadsb	-1619
Dbt	-190
Bcat2	1493
Bckdhb	2175
Auh	3182

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
	1
set	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
setSize	11
pANOVA	0.00767
s.dist	0.464
p.adjustANOVA	0.0915

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Phka1	4758
Pygm	4683
Phkg1	4612
Agl	4452
Calm1	3824
Pgm1	3704
Phkb	3570
Phkg2	2097
Phka2	-1158
Pygb	-2461
Gyg	-2876

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Phka1	4758
Pygm	4683
Phkg1	4612
Agl	4452
Calm1	3824
Pgm1	3704
Phkb	3570
Phkg2	2097
Phka2	-1158
Pygb	-2461
Gyg	-2876

REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE

REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE
	231
set	REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE
setSize	11
pANOVA	0.00814
s.dist	-0.461
p.adjustANOVA	0.0927

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Adcy6	-842
Gng11	-479
Gnao1	904

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Adcy6	-842
Gng11	-479
Gnao1	904

REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR

REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
	285
set	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
setSize	11
pANOVA	0.00842
s.dist	-0.459
p.adjustANOVA	0.0932

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Gng10	-1227
Gng11	-479
Gna13	38
Gna11	1614

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Gng10	-1227
Gng11	-479
Gna13	38
Gna11	1614

REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA

REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
	253
set	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA
setSize	12
pANOVA	0.00602
s.dist	-0.458
p.adjustANOVA	0.0737

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Pdpk1	-2472
Gnb4	-2208
Gng10	-1227
Akt3	-855
Gng11	-479
Akt1	-182
Akt2	367

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Pdpk1	-2472
Gnb4	-2208
Gng10	-1227
Akt3	-855
Gng11	-479
Akt1	-182
Akt2	367

REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM
	116
set	REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM
setSize	15
pANOVA	0.00341
s.dist	0.437
p.adjustANOVA	0.0476

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fmod	4738
Kera	4695
St3gal1	4460
Ogn	4273
Prelp	3762
Gns	3415
Hexb	3170
B4galt5	3112
B4galt1	1877
St3gal3	1649
Lum	133
Hexa	97
St3gal6	-539
St3gal2	-699
B4galt3	-1735

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fmod	4738
Kera	4695
St3gal1	4460
Ogn	4273
Prelp	3762
Gns	3415
Hexb	3170
B4galt5	3112
B4galt1	1877
St3gal3	1649
Lum	133
Hexa	97
St3gal6	-539
St3gal2	-699
B4galt3	-1735

REACTOME_KERATAN_SULFATE_BIOSYNTHESIS

REACTOME_KERATAN_SULFATE_BIOSYNTHESIS
	110
set	REACTOME_KERATAN_SULFATE_BIOSYNTHESIS
setSize	12
pANOVA	0.00939
s.dist	0.433
p.adjustANOVA	0.101

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fmod	4738
Kera	4695
St3gal1	4460
Ogn	4273
Prelp	3762
B4galt5	3112
B4galt1	1877
St3gal3	1649
Lum	133
St3gal6	-539
St3gal2	-699
B4galt3	-1735

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fmod	4738
Kera	4695
St3gal1	4460
Ogn	4273
Prelp	3762
B4galt5	3112
B4galt1	1877
St3gal3	1649
Lum	133
St3gal6	-539
St3gal2	-699
B4galt3	-1735

REACTOME_ADP_SIGNALLING_THROUGH_P2RY12

REACTOME_ADP_SIGNALLING_THROUGH_P2RY12
	287
set	REACTOME_ADP_SIGNALLING_THROUGH_P2RY12
setSize	10
pANOVA	0.0188
s.dist	-0.429
p.adjustANOVA	0.171

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Gng11	-479
Gnai3	3638

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Gng11	-479
Gnai3	3638

REACTOME_AQUAPORIN_MEDIATED_TRANSPORT

REACTOME_AQUAPORIN_MEDIATED_TRANSPORT
	344
set	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT
setSize	22
pANOVA	0.00128
s.dist	-0.397
p.adjustANOVA	0.0229

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aqp4	-4600
Gng5	-4343
Aqp1	-4253
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Adcy2	-3088
Adcy7	-2858
Rab11a	-2678
Gnb2	-2617
Gnb4	-2208
Adcy4	-1917
Gnas	-1499
Gng10	-1227
Prkar2a	-1006
Adcy6	-842
Gng11	-479
Prkacb	160
Adcy9	263
Prkar1a	481

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aqp4	-4600
Gng5	-4343
Aqp1	-4253
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Adcy2	-3088
Adcy7	-2858
Rab11a	-2678
Gnb2	-2617
Gnb4	-2208
Adcy4	-1917
Gnas	-1499
Gng10	-1227
Prkar2a	-1006
Adcy6	-842
Gng11	-479
Prkacb	160
Adcy9	263
Prkar1a	481
Prkaca	1834
Rab11fip2	2556

REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS

REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS
	347
set	REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS
setSize	22
pANOVA	0.00128
s.dist	-0.397
p.adjustANOVA	0.0229

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aqp4	-4600
Gng5	-4343
Aqp1	-4253
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Adcy2	-3088
Adcy7	-2858
Rab11a	-2678
Gnb2	-2617
Gnb4	-2208
Adcy4	-1917
Gnas	-1499
Gng10	-1227
Prkar2a	-1006
Adcy6	-842
Gng11	-479
Prkacb	160
Adcy9	263
Prkar1a	481

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aqp4	-4600
Gng5	-4343
Aqp1	-4253
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Adcy2	-3088
Adcy7	-2858
Rab11a	-2678
Gnb2	-2617
Gnb4	-2208
Adcy4	-1917
Gnas	-1499
Gng10	-1227
Prkar2a	-1006
Adcy6	-842
Gng11	-479
Prkacb	160
Adcy9	263
Prkar1a	481
Prkaca	1834
Rab11fip2	2556

REACTOME_HS_GAG_DEGRADATION

REACTOME_HS_GAG_DEGRADATION
	95
set	REACTOME_HS_GAG_DEGRADATION
setSize	10
pANOVA	0.0323
s.dist	0.391
p.adjustANOVA	0.278

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspg2	4497
Agrn	4170
Gusb	4049
Ids	3311
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Sdc2	807
Sdc4	-2670

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspg2	4497
Agrn	4170
Gusb	4049
Ids	3311
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Sdc2	807
Sdc4	-2670

REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING

REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
	262
set	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING
setSize	13
pANOVA	0.0151
s.dist	-0.389
p.adjustANOVA	0.146

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Pdpk1	-2472
Gnb4	-2208
Gng10	-1227
Akt3	-855
Gng11	-479
Akt1	-182
Akt2	367
Plcb3	2157

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Pdpk1	-2472
Gnb4	-2208
Gng10	-1227
Akt3	-855
Gng11	-479
Akt1	-182
Akt2	367
Plcb3	2157

REACTOME_SIGNAL_AMPLIFICATION

REACTOME_SIGNAL_AMPLIFICATION
	274
set	REACTOME_SIGNAL_AMPLIFICATION
setSize	15
pANOVA	0.0116
s.dist	-0.377
p.adjustANOVA	0.115

Top enriched genes

Top 20 genes
GeneID	Gene Rank
P2ry1	-4535
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Gng11	-479
Mapk14	-275
Gna13	38
Gna11	1614
Gnai3	3638

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
P2ry1	-4535
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Gng11	-479
Mapk14	-275
Gna13	38
Gna11	1614
Gnai3	3638

REACTOME_G_PROTEIN_ACTIVATION

REACTOME_G_PROTEIN_ACTIVATION
	184
set	REACTOME_G_PROTEIN_ACTIVATION
setSize	11
pANOVA	0.0314
s.dist	-0.375
p.adjustANOVA	0.276

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Gng11	-479
Gnao1	904
Gnai3	3638

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gnai2	-1282
Gng10	-1227
Gng11	-479
Gnao1	904
Gnai3	3638

REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION

REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION
	197
set	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION
setSize	17
pANOVA	0.0113
s.dist	-0.355
p.adjustANOVA	0.114

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Adcy2	-3088
Adcy7	-2858
Gnb2	-2617
Gnb4	-2208
Adcy4	-1917
Gnas	-1499
Gng10	-1227
Prkar2a	-1006
Adcy6	-842
Gng11	-479
Prkacb	160
Adcy9	263
Prkar1a	481
Prkaca	1834

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Adcy2	-3088
Adcy7	-2858
Gnb2	-2617
Gnb4	-2208
Adcy4	-1917
Gnas	-1499
Gng10	-1227
Prkar2a	-1006
Adcy6	-842
Gng11	-479
Prkacb	160
Adcy9	263
Prkar1a	481
Prkaca	1834

REACTOME_GLYCOSAMINOGLYCAN_METABOLISM

REACTOME_GLYCOSAMINOGLYCAN_METABOLISM
	118
set	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM
setSize	48
pANOVA	4.06e-05
s.dist	0.343
p.adjustANOVA	0.00126

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fmod	4738
Kera	4695
Cd44	4669
Hspg2	4497
Chpf2	4495
St3gal1	4460
Ogn	4273
Agrn	4170
Gusb	4049
B3gat3	3812
Prelp	3762
Abcc5	3707
Bgn	3569
Gns	3415
Ids	3311
Ndst2	3238
Hexb	3170
Lyve1	3150
B4galt5	3112
Dse	3092

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fmod	4738
Kera	4695
Cd44	4669
Hspg2	4497
Chpf2	4495
St3gal1	4460
Ogn	4273
Agrn	4170
Gusb	4049
B3gat3	3812
Prelp	3762
Abcc5	3707
Bgn	3569
Gns	3415
Ids	3311
Ndst2	3238
Hexb	3170
Lyve1	3150
B4galt5	3112
Dse	3092
B4galt7	2950
B4galt1	1877
St3gal3	1649
Hs6st1	1618
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Ext1	1166
Ext2	1020
Sdc2	807
Hyal2	702
Csgalnact2	421
Stab2	349
Hs2st1	268
Lum	133
Ndst1	117
Hexa	97
St3gal6	-539
St3gal2	-699
Glce	-722
Gxylt1	-915
Dcn	-926
Vcan	-947
B4galt3	-1735
Slc9a1	-1996
Chpf	-2619
Sdc4	-2670

REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING
	303
set	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING
setSize	11
pANOVA	0.0505
s.dist	-0.341
p.adjustANOVA	0.355

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gng10	-1227
Dlg1	-950
Gng11	-479
Plcb3	2157
Calm1	3824

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnb2	-2617
Gnb4	-2208
Gng10	-1227
Dlg1	-950
Gng11	-479
Plcb3	2157
Calm1	3824

REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH
	230
set	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH
setSize	35
pANOVA	0.000877
s.dist	0.325
p.adjustANOVA	0.0177

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col6a3	4708
Prnp	4699
Col5a1	4634
Col4a1	4287
Fgfr1	4229
Sptb	4175
Agrn	4170
Cacnb1	3757
Nras	3666
Ptk2	3534
Map2k2	3089
Mapk3	2608
Col4a2	2288
Map2k1	2000

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Col3a1	4823
Col1a1	4817
Col5a2	4806
Col6a1	4784
Col1a2	4766
Col6a2	4765
Col6a3	4708
Prnp	4699
Col5a1	4634
Col4a1	4287
Fgfr1	4229
Sptb	4175
Agrn	4170
Cacnb1	3757
Nras	3666
Ptk2	3534
Map2k2	3089
Mapk3	2608
Col4a2	2288
Map2k1	2000
Gfra1	923
Grb2	725
Rps6ka5	323
Hras	-90
Creb1	-690
Ywhab	-1736
Sptbn1	-2032
Cacna1s	-2042
Mapk1	-2169
Kras	-2307
Raf1	-2309
Nrtn	-2590
Sptan1	-2815
Fyn	-3001
Sos1	-3759

REACTOME_MYOGENESIS

REACTOME_MYOGENESIS
	300
set	REACTOME_MYOGENESIS
setSize	22
pANOVA	0.0101
s.dist	0.317
p.adjustANOVA	0.107

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdh15	4739
Myog	4646
Myf6	4571
Cdh4	4254
Myod1	4218
Cdc42	2905
Tcf4	2673
Abl1	2486
Mef2c	1735
Mef2a	1578
Bnip2	1569
Tcf12	1512
Neo1	1466
Ctnnb1	1312
Mef2d	999
Cdon	933
Ctnna1	900
Mapk12	824
Mapk14	-275
Tcf3	-2504

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdh15	4739
Myog	4646
Myf6	4571
Cdh4	4254
Myod1	4218
Cdc42	2905
Tcf4	2673
Abl1	2486
Mef2c	1735
Mef2a	1578
Bnip2	1569
Tcf12	1512
Neo1	1466
Ctnnb1	1312
Mef2d	999
Cdon	933
Ctnna1	900
Mapk12	824
Mapk14	-275
Tcf3	-2504
Map2k6	-2756
Tbc1d24	-2761

REACTOME_SIGNALING_BY_NODAL

REACTOME_SIGNALING_BY_NODAL
	21
set	REACTOME_SIGNALING_BY_NODAL
setSize	11
pANOVA	0.0795
s.dist	0.305
p.adjustANOVA	0.44

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acvr1b	4603
Furin	4298
Acvr2b	3583
Acvr2a	3564
Foxo3	2619
Cers1	2452
Smad2	1425
Drap1	1329
Smad4	-1686
Pcsk6	-2054
Smad3	-3197

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acvr1b	4603
Furin	4298
Acvr2b	3583
Acvr2a	3564
Foxo3	2619
Cers1	2452
Smad2	1425
Drap1	1329
Smad4	-1686
Pcsk6	-2054
Smad3	-3197

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
	394
set	REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
setSize	83
pANOVA	2.08e-06
s.dist	-0.302
p.adjustANOVA	8.77e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps29	-4585.0
Rpl37	-4471.0
Rpl38	-4451.0
Rps12-ps3	-4450.0
Rps27	-4393.0
Rps21	-4382.0
Grsf1	-4326.0
Rpl23	-4307.0
Rpl27-ps3	-4280.5
Polr2d	-4174.0
Rps17	-4135.0
Rpl24	-4089.0
Hsp90aa1	-3971.0
Rpl36al	-3949.0
Gtf2f2	-3885.0
Rpl18	-3852.0
Rps18	-3798.0
Rpl3l	-3717.0
Rpl19	-3671.0
Polr2i	-3662.0

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps29	-4585.0
Rpl37	-4471.0
Rpl38	-4451.0
Rps12-ps3	-4450.0
Rps27	-4393.0
Rps21	-4382.0
Grsf1	-4326.0
Rpl23	-4307.0
Rpl27-ps3	-4280.5
Polr2d	-4174.0
Rps17	-4135.0
Rpl24	-4089.0
Hsp90aa1	-3971.0
Rpl36al	-3949.0
Gtf2f2	-3885.0
Rpl18	-3852.0
Rps18	-3798.0
Rpl3l	-3717.0
Rpl19	-3671.0
Polr2i	-3662.0
Rpl35	-3398.0
Rpl32	-3301.0
Uba52	-3212.0
Rps26	-3128.0
Rpl23a	-3062.0
Rpl39	-3053.0
Ipo5	-2897.0
Polr2e	-2845.0
Polr2k	-2830.0
Rps15a	-2805.0
Rpl41	-2708.0
Rps25	-2701.0
Rpl11	-2680.0
Polr2h	-2643.0
Rpl37a	-2570.0
Rpl34	-2359.0
Rps4x	-2276.0
Rplp2	-2271.0
Rps23	-2090.0
Rpl18a	-1999.0
Rpsa	-1918.0
Polr2g	-1871.0
Rps3a1	-1767.0
Rpl15	-1748.0
Polr2j	-1711.0
Rpl29	-1557.0
Rplp1	-1131.0
Rps19	-1114.0
Rps5	-1059.0
Rps3	-1033.0
Rpl26	-1014.0
Rps6	-852.0
Rpl12	-806.0
Rpl28	-741.0
Rpl27a	-571.0
Polr2f	-133.0
Rps11	-51.0
Rplp0	-47.0
Gtf2f1	72.0
Rps24	184.0
Rps20	379.0
Polr2c	573.0
Rpl8	697.0
Rpl13	868.0
Rps7	938.0
Polr2l	1239.0
Rpl6	1267.0
Rps9	1287.0
Rpl3	1393.0
Rps14	1515.0
Rps16	1530.0
Rps8	1662.0
Polr2b	1815.0
Rpl4	2439.0
Rpl10a	2471.0
Dnajc3	2568.0
Rps13	2573.0
Rpl30	2873.0
Rpl14	3049.0
Rpl5	3167.0
Rpl22	3593.0
Rps27a	4160.0
Polr2a	4434.0

REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM
	113
set	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM
setSize	21
pANOVA	0.018
s.dist	0.298
p.adjustANOVA	0.167

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspg2	4497
Chpf2	4495
Agrn	4170
B3gat3	3812
Bgn	3569
Ids	3311
Hexb	3170
Dse	3092
B4galt7	2950
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Sdc2	807
Csgalnact2	421
Hexa	97
Gxylt1	-915
Dcn	-926
Vcan	-947
Chpf	-2619

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspg2	4497
Chpf2	4495
Agrn	4170
B3gat3	3812
Bgn	3569
Ids	3311
Hexb	3170
Dse	3092
B4galt7	2950
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Sdc2	807
Csgalnact2	421
Hexa	97
Gxylt1	-915
Dcn	-926
Vcan	-947
Chpf	-2619
Sdc4	-2670

REACTOME_METABOLISM_OF_PORPHYRINS

REACTOME_METABOLISM_OF_PORPHYRINS
	456
set	REACTOME_METABOLISM_OF_PORPHYRINS
setSize	11
pANOVA	0.087
s.dist	-0.298
p.adjustANOVA	0.46

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Alad	-3846
Hmox2	-3796
Blvra	-2908
Urod	-2745
Cpox	-1946
Alas1	-1592
Uros	-1378
Ppox	-913
Hmbs	-237
Fech	1928
Hmox1	2967

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Alad	-3846
Hmox2	-3796
Blvra	-2908
Urod	-2745
Cpox	-1946
Alas1	-1592
Uros	-1378
Ppox	-913
Hmbs	-237
Fech	1928
Hmox1	2967

REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE

REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE
	161
set	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE
setSize	13
pANOVA	0.0672
s.dist	0.293
p.adjustANOVA	0.405

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Slc7a2	4771
Slc7a6	3896
Slc38a2	3857
Slc3a2	2682
Slc7a8	2675
Slc1a5	2413
Slc38a4	1797
Slc43a1	1650
Slc36a1	1544
Slc6a6	1459
Slc16a10	-140
Slc43a2	-2930
Slc38a3	-4410

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Slc7a2	4771
Slc7a6	3896
Slc38a2	3857
Slc3a2	2682
Slc7a8	2675
Slc1a5	2413
Slc38a4	1797
Slc43a1	1650
Slc36a1	1544
Slc6a6	1459
Slc16a10	-140
Slc43a2	-2930
Slc38a3	-4410

REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM
	117
set	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM
setSize	23
pANOVA	0.0161
s.dist	0.29
p.adjustANOVA	0.153

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspg2	4497
Agrn	4170
Gusb	4049
B3gat3	3812
Bgn	3569
Ids	3311
Ndst2	3238
B4galt7	2950
Hs6st1	1618
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Ext1	1166
Ext2	1020
Sdc2	807
Hs2st1	268
Ndst1	117
Glce	-722
Gxylt1	-915

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspg2	4497
Agrn	4170
Gusb	4049
B3gat3	3812
Bgn	3569
Ids	3311
Ndst2	3238
B4galt7	2950
Hs6st1	1618
Idua	1387
Gpc1	1376
Gpc4	1274
Sdc3	1249
Ext1	1166
Ext2	1020
Sdc2	807
Hs2st1	268
Ndst1	117
Glce	-722
Gxylt1	-915
Dcn	-926
Vcan	-947
Sdc4	-2670

REACTOME_SIGNALING_BY_NOTCH3

REACTOME_SIGNALING_BY_NOTCH3
	79
set	REACTOME_SIGNALING_BY_NOTCH3
setSize	11
pANOVA	0.1
s.dist	-0.286
p.adjustANOVA	0.471

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aph1a	-3303
Psenen	-3196
Aph1b	-2809
Dll4	-2401
Jag1	-1824
Notch3	-1746
Adam10	-1599
Psen1	-1334
Ncstn	-667
Jag2	1448
Psen2	3579

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aph1a	-3303
Psenen	-3196
Aph1b	-2809
Dll4	-2401
Jag1	-1824
Notch3	-1746
Adam10	-1599
Psen1	-1334
Ncstn	-667
Jag2	1448
Psen2	3579

REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS

REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS
	157
set	REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS
setSize	14
pANOVA	0.0655
s.dist	-0.284
p.adjustANOVA	0.405

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acss2	-4601
Aldh1a1	-4381
Acss1	-4299
Aldh2	-4100
Maob	-3729
Fmo2	-3660
Cyp2u1	-3580
Cyp39a1	-2246
Fmo1	-442
Maoa	892
Smox	1147
Adh1	2180
Cyp27a1	4533
Cyp2e1	4787

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acss2	-4601
Aldh1a1	-4381
Acss1	-4299
Aldh2	-4100
Maob	-3729
Fmo2	-3660
Cyp2u1	-3580
Cyp39a1	-2246
Fmo1	-442
Maoa	892
Smox	1147
Adh1	2180
Cyp27a1	4533
Cyp2e1	4787

REACTOME_LIPOPROTEIN_METABOLISM

REACTOME_LIPOPROTEIN_METABOLISM
	419
set	REACTOME_LIPOPROTEIN_METABOLISM
setSize	11
pANOVA	0.105
s.dist	0.282
p.adjustANOVA	0.488

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Apoe	4717
Hspg2	4497
Bmp1	4321
Ldlr	4068
Abca1	2335
Pltp	2245
Sar1b	1971
P4hb	36
Scarb1	-365
Ldlrap1	-3542
Lpl	-4547

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Apoe	4717
Hspg2	4497
Bmp1	4321
Ldlr	4068
Abca1	2335
Pltp	2245
Sar1b	1971
P4hb	36
Scarb1	-365
Ldlrap1	-3542
Lpl	-4547

REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS

REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS
	310
set	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS
setSize	17
pANOVA	0.0476
s.dist	-0.278
p.adjustANOVA	0.351

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng5	-4343
F2r	-4122
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Mapk1	-2169
Gna12	-1427
Gng10	-1227
Gng11	-479
Gna13	38
Gna11	1614
Mapk3	2608
Arrb1	3614
Arrb2	3630

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng5	-4343
F2r	-4122
Gng12	-3895
Gnb1	-3679
Gnb5	-3266
Gnaq	-2770
Gnb2	-2617
Gnb4	-2208
Mapk1	-2169
Gna12	-1427
Gng10	-1227
Gng11	-479
Gna13	38
Gna11	1614
Mapk3	2608
Arrb1	3614
Arrb2	3630

REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS

REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
	122
set	REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
setSize	13
pANOVA	0.0842
s.dist	0.277
p.adjustANOVA	0.455

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspg2	4497
Agrn	4170
B3gat3	3812
Bgn	3569
B4galt7	2950
Gpc1	1376
Gpc4	1274
Sdc3	1249
Sdc2	807
Gxylt1	-915
Dcn	-926
Vcan	-947
Sdc4	-2670

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspg2	4497
Agrn	4170
B3gat3	3812
Bgn	3569
B4galt7	2950
Gpc1	1376
Gpc4	1274
Sdc3	1249
Sdc2	807
Gxylt1	-915
Dcn	-926
Vcan	-947
Sdc4	-2670

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
	227
set	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
setSize	15
pANOVA	0.0649
s.dist	0.275
p.adjustANOVA	0.405

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Grip2	4594
Camk2a	4462
Ap2b1	3714
Ap2s1	3597
Nsf	2461
Ap2a2	2201
Prkca	2159
Ap2a1	1556
Mdm2	1528
Myo6	-325
Camk2b	-413
Ap2m1	-942
Dlg1	-950
Camk2d	-1272
Pick1	-1412

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Grip2	4594
Camk2a	4462
Ap2b1	3714
Ap2s1	3597
Nsf	2461
Ap2a2	2201
Prkca	2159
Ap2a1	1556
Mdm2	1528
Myo6	-325
Camk2b	-413
Ap2m1	-942
Dlg1	-950
Camk2d	-1272
Pick1	-1412

REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK

REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK
	313
set	REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK
setSize	10
pANOVA	0.132
s.dist	0.275
p.adjustANOVA	0.559

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkag3	4820
Prkag2	4106
Prkab1	3792
Prkab2	3288
Prkaa2	2120
Tsc2	1407
Tsc1	795
Prkaa1	-623
Rheb	-2502
Prkag1	-3249

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkag3	4820
Prkag2	4106
Prkab1	3792
Prkab2	3288
Prkaa2	2120
Tsc2	1407
Tsc1	795
Prkaa1	-623
Rheb	-2502
Prkag1	-3249

REACTOME_SYNTHESIS_OF_PA

REACTOME_SYNTHESIS_OF_PA
	103
set	REACTOME_SYNTHESIS_OF_PA
setSize	11
pANOVA	0.125
s.dist	-0.267
p.adjustANOVA	0.537

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pla2g12a	-4613
Gpam	-4165
Agpat3	-3859
Lclat1	-3655
Gnpat	-2869
Gpd1l	-2278
Agpat5	-2083
Pld1	-185
Pld2	2566
Agpat1	3928
Gpd1	4341

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pla2g12a	-4613
Gpam	-4165
Agpat3	-3859
Lclat1	-3655
Gnpat	-2869
Gpd1l	-2278
Agpat5	-2083
Pld1	-185
Pld2	2566
Agpat1	3928
Gpd1	4341

REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA

REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA
	104
set	REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA
setSize	13
pANOVA	0.0955
s.dist	-0.267
p.adjustANOVA	0.466

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Egln3	-4619
Egln1	-4438
Epas1	-3567
Ube2d3	-3256
Uba52	-3212
Hif1a	-2149
Ube2d2a	-2130
Cul2	-1624
Rbx1	-1287
Vhl	272
Ube2d1	2524
Egln2	4140
Rps27a	4160

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Egln3	-4619
Egln1	-4438
Epas1	-3567
Ube2d3	-3256
Uba52	-3212
Hif1a	-2149
Ube2d2a	-2130
Cul2	-1624
Rbx1	-1287
Vhl	272
Ube2d1	2524
Egln2	4140
Rps27a	4160

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports