Mitch Report

date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                      stat
## 0610009B22Rik -0.08990061
## 0610009L18Rik -0.33354482
## 0610010K14Rik -1.90686802
## 0610012G03Rik  0.01318114
## 0610030E20Rik -0.84194359
## 0610040J01Rik  0.62289268

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	674
num_genes_in_profile	9701
duplicated_genes_present	0
num_profile_genes_in_sets	2865
num_profile_genes_not_in_sets	6836

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	674
num_genesets_excluded	201
num_genesets_included	473

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	2.37e-07	0.828	9.34e-06
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	8.38e-07	0.821	3.05e-05
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	1.33e-09	0.803	7.88e-08
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	10	3.50e-05	0.756	9.20e-04
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	1.17e-25	0.708	2.77e-23
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	5.12e-05	0.705	1.22e-03
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	9.26e-21	0.703	1.46e-18
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	3.13e-35	0.692	1.48e-32
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	7.91e-13	0.671	9.35e-11
REACTOME PYRUVATE METABOLISM	16	5.32e-05	0.584	1.22e-03
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	7.55e-04	0.487	1.23e-02
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	5.19e-08	0.486	2.45e-06
REACTOME PEPTIDE CHAIN ELONGATION	67	9.11e-12	-0.482	8.62e-10
REACTOME COMPLEMENT CASCADE	11	5.71e-03	-0.481	7.30e-02
REACTOME SIGNALING BY HIPPO	15	1.82e-03	-0.465	2.78e-02
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	10	1.18e-02	-0.460	1.20e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	5.54e-03	-0.444	7.27e-02
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	89	2.59e-11	-0.410	2.04e-09
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	11	2.37e-02	-0.394	1.81e-01
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	83	9.77e-10	-0.389	6.60e-08
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	21	2.45e-03	-0.382	3.51e-02
REACTOME CALNEXIN CALRETICULIN CYCLE	11	2.95e-02	-0.379	2.02e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	23	2.16e-03	-0.370	3.19e-02
REACTOME SIGNALING BY NOTCH2	12	2.68e-02	-0.369	1.95e-01
REACTOME SOS MEDIATED SIGNALLING	13	2.14e-02	-0.369	1.69e-01
REACTOME RAP1 SIGNALLING	12	2.74e-02	-0.368	1.96e-01
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	18	7.50e-03	-0.364	8.65e-02
REACTOME GLUTATHIONE CONJUGATION	12	3.08e-02	0.360	2.06e-01
REACTOME PEROXISOMAL LIPID METABOLISM	16	1.38e-02	0.356	1.31e-01
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	85	2.01e-08	-0.353	1.05e-06
REACTOME SIGNALING BY ROBO RECEPTOR	20	6.46e-03	-0.352	8.04e-02
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	42	1.32e-04	-0.341	2.60e-03
REACTOME DESTABILIZATION OF MRNA BY KSRP	14	2.80e-02	-0.339	1.96e-01
REACTOME SIGNALING BY NOTCH4	12	4.48e-02	-0.335	2.64e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	6.93e-03	0.333	8.19e-02
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	13	4.17e-02	-0.326	2.53e-01
REACTOME TELOMERE MAINTENANCE	20	1.42e-02	-0.317	1.31e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	14	4.04e-02	-0.317	2.51e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS	16	3.14e-02	-0.311	2.06e-01
REACTOME SEMAPHORIN INTERACTIONS	44	3.79e-04	-0.310	6.40e-03
REACTOME STRIATED MUSCLE CONTRACTION	22	1.22e-02	0.309	1.20e-01
REACTOME LAGGING STRAND SYNTHESIS	10	9.32e-02	-0.307	4.27e-01
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	86	1.10e-06	-0.305	3.72e-05
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	20	1.90e-02	-0.303	1.64e-01
REACTOME DESTABILIZATION OF MRNA BY BRF1	16	3.72e-02	-0.301	2.35e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	5.19e-02	-0.300	2.92e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION	19	2.37e-02	-0.300	1.81e-01
REACTOME INFLUENZA LIFE CYCLE	115	6.07e-08	-0.293	2.61e-06
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	19	2.82e-02	-0.291	1.96e-01
REACTOME REGULATION OF KIT SIGNALING	11	9.75e-02	-0.289	4.31e-01

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	13	2.37e-07	0.828000	9.34e-06
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	12	8.38e-07	0.821000	3.05e-05
REACTOME CITRIC ACID CYCLE TCA CYCLE	19	1.33e-09	0.803000	7.88e-08
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	10	3.50e-05	0.756000	9.20e-04
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	73	1.17e-25	0.708000	2.77e-23
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	11	5.12e-05	0.705000	1.22e-03
REACTOME RESPIRATORY ELECTRON TRANSPORT	59	9.26e-21	0.703000	1.46e-18
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	107	3.13e-35	0.692000	1.48e-32
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	38	7.91e-13	0.671000	9.35e-11
REACTOME PYRUVATE METABOLISM	16	5.32e-05	0.584000	1.22e-03
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	16	7.55e-04	0.487000	1.23e-02
REACTOME MITOCHONDRIAL PROTEIN IMPORT	42	5.19e-08	0.486000	2.45e-06
REACTOME PEPTIDE CHAIN ELONGATION	67	9.11e-12	-0.482000	8.62e-10
REACTOME COMPLEMENT CASCADE	11	5.71e-03	-0.481000	7.30e-02
REACTOME SIGNALING BY HIPPO	15	1.82e-03	-0.465000	2.78e-02
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	10	1.18e-02	-0.460000	1.20e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	5.54e-03	-0.444000	7.27e-02
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	89	2.59e-11	-0.410000	2.04e-09
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	11	2.37e-02	-0.394000	1.81e-01
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	83	9.77e-10	-0.389000	6.60e-08
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	21	2.45e-03	-0.382000	3.51e-02
REACTOME CALNEXIN CALRETICULIN CYCLE	11	2.95e-02	-0.379000	2.02e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	23	2.16e-03	-0.370000	3.19e-02
REACTOME SIGNALING BY NOTCH2	12	2.68e-02	-0.369000	1.95e-01
REACTOME SOS MEDIATED SIGNALLING	13	2.14e-02	-0.369000	1.69e-01
REACTOME RAP1 SIGNALLING	12	2.74e-02	-0.368000	1.96e-01
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	18	7.50e-03	-0.364000	8.65e-02
REACTOME GLUTATHIONE CONJUGATION	12	3.08e-02	0.360000	2.06e-01
REACTOME PEROXISOMAL LIPID METABOLISM	16	1.38e-02	0.356000	1.31e-01
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	85	2.01e-08	-0.353000	1.05e-06
REACTOME SIGNALING BY ROBO RECEPTOR	20	6.46e-03	-0.352000	8.04e-02
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	42	1.32e-04	-0.341000	2.60e-03
REACTOME DESTABILIZATION OF MRNA BY KSRP	14	2.80e-02	-0.339000	1.96e-01
REACTOME SIGNALING BY NOTCH4	12	4.48e-02	-0.335000	2.64e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	6.93e-03	0.333000	8.19e-02
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	13	4.17e-02	-0.326000	2.53e-01
REACTOME TELOMERE MAINTENANCE	20	1.42e-02	-0.317000	1.31e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	14	4.04e-02	-0.317000	2.51e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS	16	3.14e-02	-0.311000	2.06e-01
REACTOME SEMAPHORIN INTERACTIONS	44	3.79e-04	-0.310000	6.40e-03
REACTOME STRIATED MUSCLE CONTRACTION	22	1.22e-02	0.309000	1.20e-01
REACTOME LAGGING STRAND SYNTHESIS	10	9.32e-02	-0.307000	4.27e-01
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	86	1.10e-06	-0.305000	3.72e-05
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	20	1.90e-02	-0.303000	1.64e-01
REACTOME DESTABILIZATION OF MRNA BY BRF1	16	3.72e-02	-0.301000	2.35e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	5.19e-02	-0.300000	2.92e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION	19	2.37e-02	-0.300000	1.81e-01
REACTOME INFLUENZA LIFE CYCLE	115	6.07e-08	-0.293000	2.61e-06
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	19	2.82e-02	-0.291000	1.96e-01
REACTOME REGULATION OF KIT SIGNALING	11	9.75e-02	-0.289000	4.31e-01
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	10	1.14e-01	-0.289000	4.57e-01
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	16	5.29e-02	-0.280000	2.94e-01
REACTOME PURINE SALVAGE	10	1.33e-01	-0.275000	4.71e-01
REACTOME EXTENSION OF TELOMERES	15	6.69e-02	-0.273000	3.50e-01
REACTOME CELL CELL JUNCTION ORGANIZATION	15	6.98e-02	-0.271000	3.59e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	11	1.21e-01	-0.270000	4.71e-01
REACTOME SIGNALING BY NOTCH3	12	1.06e-01	-0.270000	4.41e-01
REACTOME GLUCONEOGENESIS	19	4.47e-02	0.266000	2.64e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	21	3.72e-02	-0.263000	2.35e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	11	1.32e-01	-0.262000	4.71e-01
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	32	1.07e-02	-0.261000	1.15e-01
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	18	5.70e-02	-0.259000	3.10e-01
REACTOME NCAM1 INTERACTIONS	16	7.63e-02	-0.256000	3.81e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS	16	7.65e-02	-0.256000	3.81e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS	12	1.26e-01	-0.255000	4.71e-01
REACTOME SHC MEDIATED SIGNALLING	13	1.18e-01	-0.251000	4.69e-01
REACTOME PLATELET SENSITIZATION BY LDL	12	1.33e-01	-0.250000	4.71e-01
REACTOME TRANSLATION	124	1.69e-06	-0.250000	5.33e-05
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	49	2.55e-03	-0.250000	3.54e-02
REACTOME MYOGENESIS	21	5.39e-02	-0.243000	2.97e-01
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	13	1.30e-01	-0.243000	4.71e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE	19	6.73e-02	-0.243000	3.50e-01
REACTOME P75NTR SIGNALS VIA NFKB	10	1.89e-01	-0.240000	5.96e-01
REACTOME REGULATION OF SIGNALING BY CBL	15	1.08e-01	-0.240000	4.45e-01
REACTOME LIPOPROTEIN METABOLISM	11	1.71e-01	-0.239000	5.65e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	18	8.00e-02	-0.238000	3.90e-01
REACTOME DNA STRAND ELONGATION	14	1.25e-01	-0.237000	4.71e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	48	4.75e-03	-0.236000	6.43e-02
REACTOME PHASE II CONJUGATION	24	4.61e-02	0.235000	2.64e-01
REACTOME TCR SIGNALING	30	2.60e-02	-0.235000	1.92e-01
REACTOME TRNA AMINOACYLATION	39	1.21e-02	0.232000	1.20e-01
REACTOME INSULIN RECEPTOR RECYCLING	15	1.29e-01	0.227000	4.71e-01
REACTOME AXON GUIDANCE	146	2.60e-06	-0.226000	7.68e-05
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	44	9.87e-03	-0.225000	1.09e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	116	5.40e-05	-0.218000	1.22e-03
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	108	1.07e-04	0.216000	2.30e-03
REACTOME INTERFERON GAMMA SIGNALING	29	4.63e-02	-0.214000	2.64e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	11	2.19e-01	-0.214000	6.53e-01
REACTOME BIOLOGICAL OXIDATIONS	39	2.13e-02	0.213000	1.69e-01
REACTOME GLUCOSE METABOLISM	44	1.46e-02	0.213000	1.32e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	11	2.27e-01	-0.210000	6.57e-01
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	18	1.23e-01	0.210000	4.71e-01
REACTOME ARMS MEDIATED ACTIVATION	14	1.75e-01	-0.210000	5.74e-01
REACTOME FRS2 MEDIATED CASCADE	18	1.25e-01	-0.209000	4.71e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	21	9.84e-02	-0.208000	4.31e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	45	1.64e-02	-0.207000	1.44e-01
REACTOME SIGNAL ATTENUATION	10	2.59e-01	-0.206000	6.84e-01
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	20	1.12e-01	-0.205000	4.53e-01
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	14	1.93e-01	-0.201000	6.02e-01
REACTOME NETRIN1 SIGNALING	22	1.03e-01	-0.201000	4.37e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	35	4.15e-02	-0.199000	2.53e-01
REACTOME SIGNALING BY NOTCH1	52	1.40e-02	-0.197000	1.31e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	24	1.02e-01	-0.193000	4.37e-01
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	11	2.75e-01	0.190000	6.99e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	21	1.32e-01	-0.190000	4.71e-01
REACTOME BASIGIN INTERACTIONS	14	2.19e-01	0.190000	6.53e-01
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	51	2.02e-02	-0.188000	1.65e-01
REACTOME SIGNALLING TO ERKS	28	8.52e-02	-0.188000	4.03e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	44	3.11e-02	0.188000	2.06e-01
REACTOME INNATE IMMUNE SYSTEM	124	3.29e-04	-0.187000	5.77e-03
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	52	1.97e-02	-0.187000	1.64e-01
REACTOME SIGNALLING TO RAS	20	1.50e-01	-0.186000	5.19e-01
REACTOME IL 3 5 AND GM CSF SIGNALING	27	1.01e-01	-0.182000	4.37e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	17	1.93e-01	-0.182000	6.02e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING	13	2.65e-01	0.179000	6.96e-01
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	15	2.35e-01	0.177000	6.63e-01
REACTOME TIE2 SIGNALING	13	2.70e-01	0.177000	6.98e-01
REACTOME SIGNALING BY RHO GTPASES	69	1.20e-02	-0.175000	1.20e-01
REACTOME SHC RELATED EVENTS	14	2.57e-01	-0.175000	6.84e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	31	9.54e-02	-0.173000	4.30e-01
REACTOME PERK REGULATED GENE EXPRESSION	22	1.60e-01	-0.173000	5.44e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	12	3.00e-01	0.173000	7.27e-01
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	22	1.64e-01	-0.171000	5.55e-01
REACTOME DEVELOPMENTAL BIOLOGY	244	5.14e-06	-0.171000	1.43e-04
REACTOME REGULATORY RNA PATHWAYS	21	1.77e-01	-0.170000	5.76e-01
REACTOME MICRORNA MIRNA BIOGENESIS	18	2.13e-01	-0.169000	6.47e-01
REACTOME COLLAGEN FORMATION	27	1.28e-01	-0.169000	4.71e-01
REACTOME G1 PHASE	25	1.44e-01	-0.169000	5.04e-01
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	10	3.55e-01	-0.169000	7.91e-01
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	17	2.29e-01	-0.169000	6.57e-01
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	17	2.29e-01	-0.169000	6.57e-01
REACTOME METABOLISM OF MRNA	179	1.24e-04	-0.167000	2.54e-03
REACTOME O LINKED GLYCOSYLATION OF MUCINS	13	2.97e-01	-0.167000	7.25e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY	37	7.92e-02	-0.167000	3.90e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	16	2.50e-01	0.166000	6.79e-01
REACTOME EGFR DOWNREGULATION	23	1.69e-01	-0.166000	5.64e-01
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	17	2.39e-01	-0.165000	6.64e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	10	3.68e-01	-0.165000	7.91e-01
REACTOME MTORC1 MEDIATED SIGNALLING	11	3.46e-01	0.164000	7.85e-01
REACTOME SULFUR AMINO ACID METABOLISM	18	2.28e-01	0.164000	6.57e-01
REACTOME GLYCOSPHINGOLIPID METABOLISM	22	1.85e-01	-0.163000	5.95e-01
REACTOME IL 2 SIGNALING	27	1.46e-01	-0.162000	5.08e-01
REACTOME MUSCLE CONTRACTION	36	9.37e-02	0.162000	4.27e-01
REACTOME RECYCLING PATHWAY OF L1	19	2.25e-01	-0.161000	6.57e-01
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	18	2.38e-01	-0.161000	6.64e-01
REACTOME GLYCOLYSIS	19	2.31e-01	0.159000	6.59e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	16	2.77e-01	0.157000	6.99e-01
REACTOME SPRY REGULATION OF FGF SIGNALING	12	3.47e-01	-0.157000	7.85e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	13	3.31e-01	-0.156000	7.75e-01
REACTOME SIGNALING BY NOTCH	76	1.98e-02	-0.155000	1.64e-01
REACTOME ACTIVATION OF GENES BY ATF4	19	2.55e-01	-0.151000	6.84e-01
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	38	1.11e-01	-0.149000	4.53e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	15	3.21e-01	-0.148000	7.71e-01
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	12	3.77e-01	-0.147000	7.91e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	107	8.79e-03	-0.147000	9.89e-02
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	11	4.01e-01	-0.146000	7.97e-01
REACTOME SIGNALING BY FGFR1 MUTANTS	21	2.46e-01	-0.146000	6.74e-01
REACTOME INWARDLY RECTIFYING K CHANNELS	11	4.05e-01	0.145000	7.97e-01
REACTOME METABOLISM OF RNA	219	2.44e-04	-0.145000	4.44e-03
REACTOME HS GAG BIOSYNTHESIS	15	3.34e-01	-0.144000	7.75e-01
REACTOME INTERFERON ALPHA BETA SIGNALING	22	2.42e-01	-0.144000	6.71e-01
REACTOME HEMOSTASIS	230	2.08e-04	-0.143000	3.94e-03
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	17	3.09e-01	0.143000	7.46e-01
REACTOME NOD1 2 SIGNALING PATHWAY	19	2.87e-01	-0.141000	7.11e-01
REACTOME REGULATION OF INSULIN SECRETION	40	1.24e-01	-0.141000	4.71e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	26	2.15e-01	-0.141000	6.48e-01
REACTOME SIGNALING BY ILS	68	4.58e-02	-0.140000	2.64e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	66	5.80e-02	-0.135000	3.12e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	56	8.08e-02	-0.135000	3.90e-01
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	15	3.68e-01	-0.134000	7.91e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	11	4.41e-01	-0.134000	8.06e-01
REACTOME SYNTHESIS OF PA	11	4.53e-01	0.131000	8.08e-01
REACTOME CTLA4 INHIBITORY SIGNALING	16	3.73e-01	-0.129000	7.91e-01
REACTOME RNA POL I TRANSCRIPTION	26	2.57e-01	-0.128000	6.84e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	58	9.15e-02	-0.128000	4.27e-01
REACTOME DIABETES PATHWAYS	92	3.64e-02	-0.127000	2.35e-01
REACTOME REGULATION OF IFNG SIGNALING	11	4.71e-01	-0.126000	8.28e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	158	6.78e-03	-0.125000	8.19e-02
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	129	1.49e-02	0.125000	1.33e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	17	3.76e-01	-0.124000	7.91e-01
REACTOME MEIOTIC SYNAPSIS	17	3.77e-01	-0.124000	7.91e-01
REACTOME G2 M CHECKPOINTS	17	3.78e-01	-0.124000	7.91e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	11	4.79e-01	0.123000	8.35e-01
REACTOME SHC MEDIATED CASCADE	11	4.82e-01	-0.122000	8.35e-01
REACTOME MRNA SPLICING MINOR PATHWAY	39	1.87e-01	-0.122000	5.96e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	25	2.93e-01	-0.122000	7.20e-01
REACTOME BASE EXCISION REPAIR	13	4.49e-01	-0.121000	8.07e-01
REACTOME CELL CELL COMMUNICATION	56	1.21e-01	-0.120000	4.71e-01
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	16	4.10e-01	-0.119000	7.97e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	17	3.96e-01	0.119000	7.97e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	41	1.89e-01	-0.119000	5.96e-01
REACTOME CELL JUNCTION ORGANIZATION	30	2.69e-01	-0.117000	6.98e-01
REACTOME CHROMOSOME MAINTENANCE	39	2.08e-01	-0.117000	6.35e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	22	3.45e-01	-0.116000	7.85e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	12	4.85e-01	-0.116000	8.35e-01
REACTOME TOLL RECEPTOR CASCADES	75	8.52e-02	-0.115000	4.03e-01
REACTOME SIGNALING BY BMP	17	4.18e-01	-0.114000	7.97e-01
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	15	4.48e-01	0.113000	8.07e-01
REACTOME TRANSCRIPTION COUPLED NER TC NER	37	2.35e-01	-0.113000	6.63e-01
REACTOME NUCLEOTIDE EXCISION REPAIR	42	2.06e-01	-0.113000	6.32e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	17	4.22e-01	-0.113000	7.97e-01
REACTOME G0 AND EARLY G1	11	5.20e-01	-0.112000	8.71e-01
REACTOME DEADENYLATION OF MRNA	16	4.44e-01	0.111000	8.06e-01
REACTOME MEMBRANE TRAFFICKING	95	6.72e-02	-0.109000	3.50e-01
REACTOME RNA POL III CHAIN ELONGATION	16	4.53e-01	-0.108000	8.08e-01
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	25	3.69e-01	0.104000	7.91e-01
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	11	5.51e-01	-0.104000	8.83e-01
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	10	5.75e-01	-0.103000	8.83e-01
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	61	1.67e-01	-0.103000	5.60e-01
REACTOME NUCLEAR SIGNALING BY ERBB4	22	4.10e-01	-0.101000	7.97e-01
REACTOME SIGNALING BY PDGF	87	1.06e-01	-0.100000	4.41e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	22	4.18e-01	0.099900	7.97e-01
REACTOME INTERFERON SIGNALING	90	1.04e-01	-0.099500	4.37e-01
REACTOME G ALPHA I SIGNALLING EVENTS	32	3.36e-01	-0.098300	7.75e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS	23	4.18e-01	-0.097700	7.97e-01
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	43	2.74e-01	0.096500	6.99e-01
REACTOME PYRIMIDINE METABOLISM	10	5.98e-01	0.096400	8.83e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	14	5.35e-01	0.095800	8.77e-01
REACTOME VIRAL MESSENGER RNA SYNTHESIS	14	5.38e-01	-0.095200	8.77e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS	15	5.24e-01	-0.095100	8.72e-01
REACTOME MEIOSIS	27	3.93e-01	-0.095100	7.97e-01
REACTOME SYNTHESIS OF PC	10	6.03e-01	0.095000	8.83e-01
REACTOME CTNNB1 PHOSPHORYLATION CASCADE	14	5.45e-01	-0.093500	8.83e-01
REACTOME SIGNAL AMPLIFICATION	15	5.32e-01	-0.093300	8.77e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	13	5.61e-01	-0.093200	8.83e-01
REACTOME UNFOLDED PROTEIN RESPONSE	64	1.99e-01	-0.092900	6.16e-01
REACTOME POTASSIUM CHANNELS	23	4.42e-01	0.092700	8.06e-01
REACTOME SPHINGOLIPID METABOLISM	38	3.27e-01	-0.092000	7.73e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	33	3.64e-01	-0.091400	7.91e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	31	3.80e-01	-0.091200	7.91e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	11	6.10e-01	-0.088800	8.83e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM	51	2.74e-01	-0.088700	6.99e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	49	2.86e-01	0.088200	7.11e-01
REACTOME GLOBAL GENOMIC NER GG NER	26	4.40e-01	-0.087600	8.06e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	11	6.19e-01	0.086700	8.83e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	41	3.37e-01	0.086700	7.75e-01
REACTOME GLUCOSE TRANSPORT	31	4.04e-01	0.086600	7.97e-01
REACTOME SIGNALING BY NODAL	11	6.20e-01	-0.086300	8.83e-01
REACTOME APOPTOTIC EXECUTION PHASE	29	4.22e-01	-0.086300	7.97e-01
REACTOME G ALPHA Q SIGNALLING EVENTS	45	3.23e-01	0.085300	7.71e-01
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	19	5.20e-01	-0.085300	8.71e-01
REACTOME G ALPHA1213 SIGNALLING EVENTS	45	3.25e-01	-0.085000	7.71e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	18	5.38e-01	-0.083900	8.77e-01
REACTOME SIGNALLING BY NGF	159	7.33e-02	-0.082700	3.73e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	28	4.54e-01	-0.081800	8.08e-01
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	10	6.55e-01	0.081700	8.90e-01
REACTOME IMMUNE SYSTEM	542	1.47e-03	-0.081200	2.32e-02
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	24	5.01e-01	-0.079400	8.49e-01
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	44	3.65e-01	0.079000	7.91e-01
REACTOME INTEGRATION OF ENERGY METABOLISM	63	2.82e-01	-0.078500	7.07e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	28	4.79e-01	0.077400	8.35e-01
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	52	3.36e-01	-0.077300	7.75e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	73	2.57e-01	-0.076800	6.84e-01
REACTOME SIGNALING BY FGFR MUTANTS	28	4.84e-01	-0.076500	8.35e-01
REACTOME GABA RECEPTOR ACTIVATION	16	5.97e-01	0.076400	8.83e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	65	2.94e-01	-0.075400	7.20e-01
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	21	5.50e-01	-0.075300	8.83e-01
REACTOME RNA POL I TRANSCRIPTION INITIATION	23	5.33e-01	-0.075100	8.77e-01
REACTOME METABOLISM OF PROTEINS	310	2.47e-02	-0.074900	1.85e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	43	3.97e-01	0.074800	7.97e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	15	6.22e-01	-0.073600	8.83e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	30	4.88e-01	0.073300	8.35e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	5.71e-01	0.073200	8.83e-01
REACTOME MRNA 3 END PROCESSING	31	4.85e-01	0.072600	8.35e-01
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	41	4.23e-01	0.072400	7.97e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	47	3.96e-01	-0.071700	7.97e-01
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	44	4.11e-01	0.071700	7.97e-01
REACTOME RNA POL I TRANSCRIPTION TERMINATION	19	5.89e-01	-0.071600	8.83e-01
REACTOME PPARA ACTIVATES GENE EXPRESSION	81	2.69e-01	0.071200	6.98e-01
REACTOME NEPHRIN INTERACTIONS	15	6.34e-01	0.070900	8.83e-01
REACTOME SIGNAL TRANSDUCTION BY L1	28	5.21e-01	-0.070100	8.71e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	16	6.29e-01	-0.069700	8.83e-01
REACTOME SIGNALING BY SCF KIT	59	3.62e-01	-0.068800	7.91e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM	15	6.47e-01	-0.068400	8.90e-01
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	43	4.39e-01	0.068400	8.06e-01
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	43	4.45e-01	0.067400	8.06e-01
REACTOME L1CAM INTERACTIONS	51	4.07e-01	-0.067300	7.97e-01
REACTOME PI3K CASCADE	46	4.32e-01	0.067100	8.04e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	23	5.78e-01	0.067000	8.83e-01
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	19	6.14e-01	-0.066900	8.83e-01
REACTOME SIGNALING BY GPCR	154	1.57e-01	-0.066400	5.38e-01
REACTOME GPCR DOWNSTREAM SIGNALING	113	2.26e-01	-0.066100	6.57e-01
REACTOME HS GAG DEGRADATION	11	7.05e-01	0.066000	9.31e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	22	5.95e-01	-0.065600	8.83e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	7.07e-01	0.065400	9.32e-01
REACTOME LYSOSOME VESICLE BIOGENESIS	18	6.31e-01	-0.065400	8.83e-01
REACTOME ERK MAPK TARGETS	18	6.31e-01	-0.065400	8.83e-01
REACTOME DOWNSTREAM TCR SIGNALING	20	6.17e-01	-0.064700	8.83e-01
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	38	4.94e-01	-0.064100	8.44e-01
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	50	4.35e-01	0.064000	8.06e-01
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	30	5.49e-01	0.063300	8.83e-01
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	22	6.12e-01	0.062500	8.83e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	24	5.97e-01	0.062500	8.83e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	10	7.32e-01	0.062400	9.35e-01
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	13	6.97e-01	-0.062300	9.30e-01
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	47	4.60e-01	0.062300	8.12e-01
REACTOME SIGNALING BY ERBB4	67	3.82e-01	-0.061900	7.92e-01
REACTOME PLC BETA MEDIATED EVENTS	21	6.25e-01	-0.061600	8.83e-01
REACTOME DNA REPAIR	72	3.73e-01	-0.060900	7.91e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	22	6.26e-01	-0.060100	8.83e-01
REACTOME CELL CYCLE	221	1.26e-01	-0.060100	4.71e-01
REACTOME MRNA CAPPING	28	5.87e-01	0.059400	8.83e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	72	3.85e-01	-0.059300	7.95e-01
REACTOME ACTIVATED TLR4 SIGNALLING	62	4.27e-01	-0.058400	8.00e-01
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	17	6.77e-01	-0.058400	9.10e-01
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	177	1.84e-01	0.058200	5.95e-01
REACTOME METABOLISM OF POLYAMINES	12	7.29e-01	0.057800	9.35e-01
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	285	9.64e-02	0.057700	4.30e-01
REACTOME ADP SIGNALLING THROUGH P2RY12	10	7.53e-01	-0.057500	9.36e-01
REACTOME METABOLISM OF PORPHYRINS	11	7.42e-01	0.057300	9.36e-01
REACTOME SIGNALING BY EGFR IN CANCER	85	3.63e-01	-0.057200	7.91e-01
REACTOME IL1 SIGNALING	26	6.14e-01	-0.057200	8.83e-01
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	19	6.70e-01	-0.056500	9.06e-01
REACTOME ADP SIGNALLING THROUGH P2RY1	12	7.36e-01	0.056200	9.35e-01
REACTOME MITOTIC G1 G1 S PHASES	84	3.75e-01	-0.056100	7.91e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	22	6.49e-01	0.056000	8.90e-01
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	46	5.12e-01	0.056000	8.64e-01
REACTOME PI 3K CASCADE	35	5.69e-01	0.055700	8.83e-01
REACTOME MITOTIC G2 G2 M PHASES	50	4.98e-01	-0.055500	8.47e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	32	5.95e-01	0.054400	8.83e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	99	3.57e-01	0.053700	7.91e-01
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	103	3.52e-01	-0.053200	7.91e-01
REACTOME DOUBLE STRAND BREAK REPAIR	13	7.40e-01	0.053200	9.36e-01
REACTOME SIGNALING BY FGFR IN DISEASE	85	4.02e-01	-0.052700	7.97e-01
REACTOME ADAPTIVE IMMUNE SYSTEM	354	9.39e-02	-0.052400	4.27e-01
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	38	5.79e-01	0.052000	8.83e-01
REACTOME CIRCADIAN CLOCK	42	5.61e-01	-0.051900	8.83e-01
REACTOME NEURONAL SYSTEM	90	3.99e-01	-0.051500	7.97e-01
REACTOME PLATELET CALCIUM HOMEOSTASIS	10	7.81e-01	0.050900	9.36e-01
REACTOME PKB MEDIATED EVENTS	27	6.54e-01	0.049900	8.90e-01
REACTOME ERKS ARE INACTIVATED	10	7.86e-01	-0.049700	9.36e-01
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	37	6.01e-01	-0.049700	8.83e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	13	7.58e-01	-0.049500	9.36e-01
REACTOME RNA POL II TRANSCRIPTION	87	4.28e-01	0.049300	8.00e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	11	7.78e-01	-0.049000	9.36e-01
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	28	6.54e-01	-0.049000	8.90e-01
REACTOME RNA POL III TRANSCRIPTION TERMINATION	18	7.20e-01	-0.048900	9.35e-01
REACTOME METABOLISM OF CARBOHYDRATES	135	3.28e-01	0.048900	7.73e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS	38	6.05e-01	0.048600	8.83e-01
REACTOME CELL CYCLE MITOTIC	194	2.46e-01	-0.048600	6.74e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	166	2.83e-01	0.048600	7.07e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	29	6.52e-01	0.048400	8.90e-01
REACTOME PI3K AKT ACTIVATION	31	6.44e-01	0.048000	8.90e-01
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	82	4.60e-01	0.047300	8.12e-01
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	54	5.52e-01	0.046800	8.83e-01
REACTOME TRIF MEDIATED TLR3 SIGNALING	54	5.54e-01	-0.046600	8.83e-01
REACTOME REGULATION OF MITOTIC CELL CYCLE	61	5.34e-01	0.046100	8.77e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	14	7.65e-01	-0.046100	9.36e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	15	7.58e-01	0.046000	9.36e-01
REACTOME MEIOTIC RECOMBINATION	10	8.02e-01	-0.045800	9.38e-01
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	52	5.69e-01	0.045800	8.83e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	12	7.85e-01	-0.045600	9.36e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN	50	5.87e-01	0.044400	8.83e-01
REACTOME INSULIN SYNTHESIS AND PROCESSING	13	7.82e-01	0.044300	9.36e-01
REACTOME PIP3 ACTIVATES AKT SIGNALING	25	7.03e-01	0.044100	9.31e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	13	7.86e-01	-0.043600	9.36e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION	62	5.57e-01	-0.043200	8.83e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	23	7.23e-01	-0.042800	9.35e-01
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	13	7.90e-01	-0.042700	9.36e-01
REACTOME SMOOTH MUSCLE CONTRACTION	18	7.57e-01	-0.042200	9.36e-01
REACTOME G ALPHA S SIGNALLING EVENTS	29	6.96e-01	0.042000	9.30e-01
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	58	5.82e-01	-0.041900	8.83e-01
REACTOME MRNA PROCESSING	142	3.92e-01	0.041800	7.97e-01
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	57	5.88e-01	0.041500	8.83e-01
REACTOME IL RECEPTOR SHC SIGNALING	16	7.74e-01	0.041500	9.36e-01
REACTOME ENOS ACTIVATION AND REGULATION	12	8.06e-01	-0.041000	9.38e-01
REACTOME GABA B RECEPTOR ACTIVATION	15	7.84e-01	0.040900	9.36e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	17	7.75e-01	0.040000	9.36e-01
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	54	6.19e-01	0.039200	8.83e-01
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	52	6.33e-01	-0.038300	8.83e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS	12	8.18e-01	0.038300	9.42e-01
REACTOME HIV INFECTION	160	4.10e-01	0.038000	7.97e-01
REACTOME RNA POL III TRANSCRIPTION	31	7.19e-01	-0.037400	9.35e-01
REACTOME ELONGATION ARREST AND RECOVERY	24	7.54e-01	-0.037000	9.36e-01
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	14	8.11e-01	-0.037000	9.38e-01
REACTOME SIGNALING BY INSULIN RECEPTOR	74	5.86e-01	0.036700	8.83e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	57	6.46e-01	0.035300	8.90e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	12	8.37e-01	-0.034400	9.47e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	192	4.21e-01	0.033900	7.97e-01
REACTOME CA DEPENDENT EVENTS	14	8.27e-01	-0.033700	9.43e-01
REACTOME SIGNALING BY WNT	57	6.63e-01	0.033400	8.98e-01
REACTOME SIGNALING BY ERBB2	69	6.33e-01	-0.033300	8.83e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI	14	8.29e-01	-0.033300	9.43e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	24	7.80e-01	0.033000	9.36e-01
REACTOME MITOTIC PROMETAPHASE	47	6.98e-01	-0.032800	9.30e-01
REACTOME PI METABOLISM	38	7.28e-01	-0.032700	9.35e-01
REACTOME PROTEIN FOLDING	40	7.23e-01	0.032400	9.35e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	13	8.43e-01	0.031800	9.51e-01
REACTOME DAG AND IP3 SIGNALING	17	8.23e-01	-0.031300	9.43e-01
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	46	7.14e-01	0.031200	9.35e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS	100	5.97e-01	0.030700	8.83e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES	17	8.28e-01	-0.030400	9.43e-01
REACTOME METABOLISM OF NON CODING RNA	43	7.34e-01	-0.030000	9.35e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	22	8.09e-01	-0.029700	9.38e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	31	7.75e-01	-0.029600	9.36e-01
REACTOME APOPTOSIS	99	6.17e-01	-0.029200	8.83e-01
REACTOME PHOSPHOLIPID METABOLISM	119	5.91e-01	0.028600	8.83e-01
REACTOME S PHASE	73	6.77e-01	-0.028300	9.10e-01
REACTOME REGULATION OF APOPTOSIS	49	7.35e-01	0.028000	9.35e-01
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	49	7.37e-01	0.027700	9.35e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	28	8.00e-01	-0.027700	9.38e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	19	8.35e-01	0.027600	9.47e-01
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	57	7.22e-01	-0.027300	9.35e-01
REACTOME CHOLESTEROL BIOSYNTHESIS	13	8.67e-01	0.026900	9.67e-01
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	13	8.68e-01	0.026700	9.67e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	13	8.70e-01	0.026300	9.67e-01
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	37	7.89e-01	0.025500	9.36e-01
REACTOME SIGNALING BY FGFR	72	7.24e-01	-0.024200	9.35e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	13	8.81e-01	-0.024000	9.67e-01
REACTOME GENERIC TRANSCRIPTION PATHWAY	139	6.31e-01	-0.023700	8.83e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	63	7.47e-01	-0.023600	9.36e-01
REACTOME OPIOID SIGNALLING	42	7.98e-01	0.022800	9.38e-01
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	35	8.21e-01	0.022200	9.42e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	16	8.78e-01	0.022100	9.67e-01
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	42	8.05e-01	-0.022000	9.38e-01
REACTOME BOTULINUM NEUROTOXICITY	10	9.04e-01	-0.022000	9.73e-01
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	10	9.04e-01	-0.022000	9.73e-01
REACTOME PHOSPHORYLATION OF THE APC C	14	8.87e-01	-0.021900	9.72e-01
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	56	7.83e-01	-0.021400	9.36e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	43	8.09e-01	-0.021300	9.38e-01
REACTOME M G1 TRANSITION	52	7.94e-01	0.020900	9.38e-01
REACTOME GPCR LIGAND BINDING	43	8.13e-01	0.020900	9.38e-01
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	26	8.60e-01	-0.020000	9.64e-01
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	19	8.81e-01	0.019900	9.67e-01
REACTOME TRANSCRIPTION	128	7.04e-01	0.019500	9.31e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	53	8.11e-01	0.019000	9.38e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	21	8.81e-01	-0.018900	9.67e-01
REACTOME P38MAPK EVENTS	10	9.20e-01	-0.018300	9.75e-01
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	19	8.93e-01	-0.017900	9.73e-01
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	25	8.80e-01	0.017400	9.67e-01
REACTOME DNA REPLICATION	112	7.52e-01	-0.017400	9.36e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	11	9.21e-01	-0.017300	9.75e-01
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	16	9.07e-01	-0.016800	9.73e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	103	7.75e-01	-0.016300	9.36e-01
REACTOME G PROTEIN ACTIVATION	11	9.26e-01	0.016300	9.75e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	127	7.59e-01	0.015800	9.36e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	25	9.00e-01	-0.014600	9.73e-01
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	18	9.19e-01	-0.013900	9.75e-01
REACTOME DARPP 32 EVENTS	18	9.21e-01	-0.013500	9.75e-01
REACTOME SYNTHESIS OF DNA	62	8.59e-01	-0.013000	9.64e-01
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	21	9.22e-01	0.012400	9.75e-01
REACTOME GAB1 SIGNALOSOME	33	9.06e-01	0.011900	9.73e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	39	8.98e-01	0.011900	9.73e-01
REACTOME PURINE METABOLISM	27	9.23e-01	-0.010700	9.75e-01
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	18	9.37e-01	-0.010700	9.83e-01
REACTOME MRNA SPLICING	100	8.54e-01	0.010700	9.61e-01
REACTOME CELL CYCLE CHECKPOINTS	79	8.72e-01	-0.010500	9.67e-01
REACTOME METAL ION SLC TRANSPORTERS	12	9.52e-01	0.009980	9.91e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	11	9.60e-01	0.008730	9.91e-01
REACTOME CD28 CO STIMULATION	23	9.43e-01	-0.008540	9.85e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	15	9.57e-01	0.008050	9.91e-01
REACTOME PLATELET HOMEOSTASIS	35	9.35e-01	-0.007930	9.83e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	58	9.17e-01	0.007920	9.75e-01
REACTOME HIV LIFE CYCLE	96	8.96e-01	-0.007750	9.73e-01
REACTOME LATE PHASE OF HIV LIFE CYCLE	88	9.03e-01	0.007550	9.73e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	16	9.64e-01	0.006570	9.93e-01
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	28	9.54e-01	-0.006370	9.91e-01
REACTOME METABOLISM OF NUCLEOTIDES	49	9.40e-01	-0.006210	9.84e-01
REACTOME ION CHANNEL TRANSPORT	18	9.70e-01	0.005130	9.94e-01
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	11	9.79e-01	-0.004520	9.94e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	63	9.60e-01	0.003680	9.91e-01
REACTOME IRON UPTAKE AND TRANSPORT	23	9.79e-01	-0.003220	9.94e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	21	9.81e-01	0.003050	9.94e-01
REACTOME G ALPHA Z SIGNALLING EVENTS	22	9.82e-01	0.002820	9.94e-01
REACTOME ER PHAGOSOME PATHWAY	50	9.73e-01	0.002780	9.94e-01
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	17	9.85e-01	-0.002610	9.96e-01
REACTOME MITOTIC M M G1 PHASES	100	9.70e-01	0.002160	9.94e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	60	9.80e-01	0.001840	9.94e-01
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	13	9.91e-01	-0.001790	9.99e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	17	9.95e-01	0.000875	9.99e-01
REACTOME G1 S TRANSITION	69	9.93e-01	-0.000575	9.99e-01
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	25	9.98e-01	0.000347	9.99e-01
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	11	9.99e-01	-0.000188	9.99e-01

Detailed Gene set reports

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
	170
set	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize	13
pANOVA	2.37e-07
s.dist	0.828
p.adjustANOVA	9.34e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hadhb	4623
Acadvl	4597
Acadm	4545
Acadl	4529
Mcee	4512
Hadha	4475
Decr1	4474
Eci1	4403
Hadh	4304
Echs1	4179
Acads	2545
Pccb	1703
Pcca	1484

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hadhb	4623
Acadvl	4597
Acadm	4545
Acadl	4529
Mcee	4512
Hadha	4475
Decr1	4474
Eci1	4403
Hadh	4304
Echs1	4179
Acads	2545
Pccb	1703
Pcca	1484

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
	416
set	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
setSize	12
pANOVA	8.38e-07
s.dist	0.821
p.adjustANOVA	3.05e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Atp5a1	4517
Atp5b	4466
Atp5h	4384
Atp5j	4309
Atp5o	4182
Atp5j2	4117
Atp5c1	4100
Atp5d	3948
Atp5g1	3474
Atp5k	3447
Atp5l	3323
Atp5e	1861

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Atp5a1	4517
Atp5b	4466
Atp5h	4384
Atp5j	4309
Atp5o	4182
Atp5j2	4117
Atp5c1	4100
Atp5d	3948
Atp5g1	3474
Atp5k	3447
Atp5l	3323
Atp5e	1861

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
	224
set	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
setSize	19
pANOVA	1.33e-09
s.dist	0.803
p.adjustANOVA	7.88e-08

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dld	4570
Idh3b	4508
Fh1	4444
Sdha	4425
Aco2	4361
Sdhb	4343
Sucla2	4341
Idh3a	4241
Sdhd	4125
Ogdh	4098
Mdh2	4069
Idh2	4020
Dlst	3900
Idh3g	3734
Suclg2	3624
Sdhc	3319
Cs	2932
Nnt	1203
Suclg1	1080

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dld	4570
Idh3b	4508
Fh1	4444
Sdha	4425
Aco2	4361
Sdhb	4343
Sucla2	4341
Idh3a	4241
Sdhd	4125
Ogdh	4098
Mdh2	4069
Idh2	4020
Dlst	3900
Idh3g	3734
Suclg2	3624
Sdhc	3319
Cs	2932
Nnt	1203
Suclg1	1080

REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION

REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION
	343
set	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION
setSize	10
pANOVA	3.5e-05
s.dist	0.756
p.adjustANOVA	0.00092

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gpt	4618
Got1	4495
Aldh18a1	4285
Got2	4258
Glud1	4016
Gpt2	3988
Oat	3435
Psph	3031
Glul	2624
Gls	526

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gpt	4618
Got1	4495
Aldh18a1	4285
Got2	4258
Glud1	4016
Gpt2	3988
Oat	3435
Psph	3031
Glul	2624
Gls	526

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
	410
set	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
setSize	73
pANOVA	1.17e-25
s.dist	0.708
p.adjustANOVA	2.77e-23

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ucp3	4716
Ndufs1	4673
Uqcrc2	4586
Ndufb7	4554
Ndufa5	4546
Atp5a1	4517
Ndufv2	4479
Atp5b	4466
Ndufa9	4431
Sdha	4425
Atp5h	4384
Etfdh	4363
Sdhb	4343
Ndufv1	4333
Atp5j	4309
Ndufb9	4272
Ndufa8	4215
Etfa	4185
Atp5o	4182
Etfb	4156

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ucp3	4716
Ndufs1	4673
Uqcrc2	4586
Ndufb7	4554
Ndufa5	4546
Atp5a1	4517
Ndufv2	4479
Atp5b	4466
Ndufa9	4431
Sdha	4425
Atp5h	4384
Etfdh	4363
Sdhb	4343
Ndufv1	4333
Atp5j	4309
Ndufb9	4272
Ndufa8	4215
Etfa	4185
Atp5o	4182
Etfb	4156
Sdhd	4125
Uqcrfs1	4121
Atp5j2	4117
Atp5c1	4100
Cycs	4041
Ndufs3	4010
Ndufb5	3995
Cox6c	3955
Atp5d	3948
Ndufb3	3856
Ndufa4	3782
Ndufs5	3749
Ndufa12	3736
Ndufa11	3700
Ndufs8	3644
Ndufs6	3622
Cox6b1	3571
Uqcrh	3512
Atp5g1	3474
Ndufa10	3453
Atp5k	3447
Cyc1	3422
Uqcr11	3372
Uqcrb	3359
Atp5l	3323
Sdhc	3319
Cox7a2l	3286
Cox7c	3236
Ndufa6	3227
Cox4i1	3204
Ndufc2	3184
Ndufs2	3105
Ndufb10	3056
Cox5a	3006
Uqcrq	2990
Ndufb6	2941
Ndufs4	2864
Ndufab1	2682
Ndufa13	2622
Uqcrc1	2252
Cox6a1	2242
Ndufa2	2000
Ndufa1	1992
Ndufa7	1888
Atp5e	1861
Ndufb2	1741
Ndufc1	1656
Ndufs7	1467
Cox8a	1151
Ndufb4	595
Ndufv3	167
Ndufa3	-404
Ucp2	-3752

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
	137
set	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
setSize	11
pANOVA	5.12e-05
s.dist	0.705
p.adjustANOVA	0.00122

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdk4	4670
Pdhb	4657
Dld	4570
Pdha1	4537
Pdpr	3814
Dlat	3733
Pdk1	3606
Pdp2	3259
Pdhx	3050
Pdk2	1405
Pdp1	-1189

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdk4	4670
Pdhb	4657
Dld	4570
Pdha1	4537
Pdpr	3814
Dlat	3733
Pdk1	3606
Pdp2	3259
Pdhx	3050
Pdk2	1405
Pdp1	-1189

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
	336
set	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
setSize	59
pANOVA	9.26e-21
s.dist	0.703
p.adjustANOVA	1.46e-18

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ndufs1	4673
Uqcrc2	4586
Ndufb7	4554
Ndufa5	4546
Ndufv2	4479
Ndufa9	4431
Sdha	4425
Etfdh	4363
Sdhb	4343
Ndufv1	4333
Ndufb9	4272
Ndufa8	4215
Etfa	4185
Etfb	4156
Sdhd	4125
Uqcrfs1	4121
Cycs	4041
Ndufs3	4010
Ndufb5	3995
Cox6c	3955

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ndufs1	4673
Uqcrc2	4586
Ndufb7	4554
Ndufa5	4546
Ndufv2	4479
Ndufa9	4431
Sdha	4425
Etfdh	4363
Sdhb	4343
Ndufv1	4333
Ndufb9	4272
Ndufa8	4215
Etfa	4185
Etfb	4156
Sdhd	4125
Uqcrfs1	4121
Cycs	4041
Ndufs3	4010
Ndufb5	3995
Cox6c	3955
Ndufb3	3856
Ndufa4	3782
Ndufs5	3749
Ndufa12	3736
Ndufa11	3700
Ndufs8	3644
Ndufs6	3622
Cox6b1	3571
Uqcrh	3512
Ndufa10	3453
Cyc1	3422
Uqcr11	3372
Uqcrb	3359
Sdhc	3319
Cox7a2l	3286
Cox7c	3236
Ndufa6	3227
Cox4i1	3204
Ndufc2	3184
Ndufs2	3105
Ndufb10	3056
Cox5a	3006
Uqcrq	2990
Ndufb6	2941
Ndufs4	2864
Ndufab1	2682
Ndufa13	2622
Uqcrc1	2252
Cox6a1	2242
Ndufa2	2000
Ndufa1	1992
Ndufa7	1888
Ndufb2	1741
Ndufc1	1656
Ndufs7	1467
Cox8a	1151
Ndufb4	595
Ndufv3	167
Ndufa3	-404

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
	24
set	REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
setSize	107
pANOVA	3.13e-35
s.dist	0.692
p.adjustANOVA	1.48e-32

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ucp3	4716
Ndufs1	4673
Pdk4	4670
Pdhb	4657
Slc16a1	4655
Uqcrc2	4586
Dld	4570
Ndufb7	4554
Ndufa5	4546
Pdha1	4537
Atp5a1	4517
Idh3b	4508
Ndufv2	4479
Atp5b	4466
Fh1	4444
Ndufa9	4431
Sdha	4425
Atp5h	4384
Etfdh	4363
Aco2	4361

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ucp3	4716
Ndufs1	4673
Pdk4	4670
Pdhb	4657
Slc16a1	4655
Uqcrc2	4586
Dld	4570
Ndufb7	4554
Ndufa5	4546
Pdha1	4537
Atp5a1	4517
Idh3b	4508
Ndufv2	4479
Atp5b	4466
Fh1	4444
Ndufa9	4431
Sdha	4425
Atp5h	4384
Etfdh	4363
Aco2	4361
Sdhb	4343
Sucla2	4341
Ndufv1	4333
Atp5j	4309
Ndufb9	4272
Idh3a	4241
Ndufa8	4215
Idh1	4204
Etfa	4185
Atp5o	4182
Etfb	4156
Sdhd	4125
Uqcrfs1	4121
Atp5j2	4117
Atp5c1	4100
Ogdh	4098
Mdh2	4069
Cycs	4041
Adhfe1	4032
L2hgdh	4026
Idh2	4020
Ndufs3	4010
Ndufb5	3995
Cox6c	3955
Atp5d	3948
Dlst	3900
Ndufb3	3856
Pdpr	3814
Ndufa4	3782
Ldhb	3767
Ndufs5	3749
Ndufa12	3736
Idh3g	3734
Dlat	3733
Ndufa11	3700
Ndufs8	3644
Suclg2	3624
Ndufs6	3622
Pdk1	3606
Cox6b1	3571
Uqcrh	3512
Atp5g1	3474
Ndufa10	3453
Atp5k	3447
Cyc1	3422
Uqcr11	3372
Uqcrb	3359
Atp5l	3323
Sdhc	3319
Cox7a2l	3286
Pdp2	3259
Cox7c	3236
Ndufa6	3227
Cox4i1	3204
Ndufc2	3184
Ndufs2	3105
Ndufb10	3056
Pdhx	3050
Cox5a	3006
Uqcrq	2990
Ndufb6	2941
Cs	2932
Ndufs4	2864
Ndufab1	2682
Ndufa13	2622
Uqcrc1	2252
Cox6a1	2242
Ndufa2	2000
Ndufa1	1992
Ndufa7	1888
Atp5e	1861
Ndufb2	1741
Ndufc1	1656
Ndufs7	1467
Pdk2	1405
Bsg	1395
Nnt	1203
Cox8a	1151
Suclg1	1080
Ndufb4	595
Ndufv3	167
Ndufa3	-404
Pdp1	-1189
Ldha	-1246
Slc16a3	-1611
Ucp2	-3752
D2hgdh	-3932

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
	5
set	REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
setSize	38
pANOVA	7.91e-13
s.dist	0.671
p.adjustANOVA	9.35e-11

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdk4	4670
Pdhb	4657
Slc16a1	4655
Dld	4570
Pdha1	4537
Idh3b	4508
Fh1	4444
Sdha	4425
Aco2	4361
Sdhb	4343
Sucla2	4341
Idh3a	4241
Idh1	4204
Sdhd	4125
Ogdh	4098
Mdh2	4069
Adhfe1	4032
L2hgdh	4026
Idh2	4020
Dlst	3900

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdk4	4670
Pdhb	4657
Slc16a1	4655
Dld	4570
Pdha1	4537
Idh3b	4508
Fh1	4444
Sdha	4425
Aco2	4361
Sdhb	4343
Sucla2	4341
Idh3a	4241
Idh1	4204
Sdhd	4125
Ogdh	4098
Mdh2	4069
Adhfe1	4032
L2hgdh	4026
Idh2	4020
Dlst	3900
Pdpr	3814
Ldhb	3767
Idh3g	3734
Dlat	3733
Suclg2	3624
Pdk1	3606
Sdhc	3319
Pdp2	3259
Pdhx	3050
Cs	2932
Pdk2	1405
Bsg	1395
Nnt	1203
Suclg1	1080
Pdp1	-1189
Ldha	-1246
Slc16a3	-1611
D2hgdh	-3932

REACTOME_PYRUVATE_METABOLISM

REACTOME_PYRUVATE_METABOLISM
	295
set	REACTOME_PYRUVATE_METABOLISM
setSize	16
pANOVA	5.32e-05
s.dist	0.584
p.adjustANOVA	0.00122

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pdk4	4670
Pdhb	4657
Slc16a1	4655
Dld	4570
Pdha1	4537
Pdpr	3814
Ldhb	3767
Dlat	3733
Pdk1	3606
Pdp2	3259
Pdhx	3050
Pdk2	1405
Bsg	1395
Pdp1	-1189
Ldha	-1246
Slc16a3	-1611

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pdk4	4670
Pdhb	4657
Slc16a1	4655
Dld	4570
Pdha1	4537
Pdpr	3814
Ldhb	3767
Dlat	3733
Pdk1	3606
Pdp2	3259
Pdhx	3050
Pdk2	1405
Bsg	1395
Pdp1	-1189
Ldha	-1246
Slc16a3	-1611

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
	275
set	REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
setSize	16
pANOVA	0.000755
s.dist	0.487
p.adjustANOVA	0.0123

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aldh6a1	4704
Acat1	4571
Dld	4570
Hibadh	4373
Ivd	4067
Dbt	3802
Acadsb	3257
Mccc2	2830
Bcat2	2319
Acad8	2081
Hsd17b10	1894
Hibch	1584
Bckdha	1141
Mccc1	-1152
Auh	-1588
Bckdhb	-2897

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aldh6a1	4704
Acat1	4571
Dld	4570
Hibadh	4373
Ivd	4067
Dbt	3802
Acadsb	3257
Mccc2	2830
Bcat2	2319
Acad8	2081
Hsd17b10	1894
Hibch	1584
Bckdha	1141
Mccc1	-1152
Auh	-1588
Bckdhb	-2897

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
	64
set	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
setSize	42
pANOVA	5.19e-08
s.dist	0.486
p.adjustANOVA	2.45e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Timm8a1	4588
Hspa9	4568
Timm17a	4539
Timm9	4520
Atp5a1	4517
Atp5b	4466
Mtx2	4449
Timm10	4387
Grpel1	4376
Aco2	4361
Slc25a12	4257
Slc25a4	4255
Timm44	4211
Hspd1	3881
Samm50	3798
Idh3g	3734
Tomm5	3529
Vdac1	3504
Atp5g1	3474
Cyc1	3422

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Timm8a1	4588
Hspa9	4568
Timm17a	4539
Timm9	4520
Atp5a1	4517
Atp5b	4466
Mtx2	4449
Timm10	4387
Grpel1	4376
Aco2	4361
Slc25a12	4257
Slc25a4	4255
Timm44	4211
Hspd1	3881
Samm50	3798
Idh3g	3734
Tomm5	3529
Vdac1	3504
Atp5g1	3474
Cyc1	3422
Bcs1l	2997
Cs	2932
Timm8b	2856
Timm50	2707
Pmpcb	2385
Tomm7	2213
Gfer	1816
Tomm20	1556
Grpel2	1208
Timm22	1193
Timm23	694
Tomm40	653
Tomm22	434
Pmpca	202
Dnajc19	-660
Timm13	-1007
Mtx1	-1047
Fxn	-1335
Hscb	-1853
Coq2	-2273
Ldhd	-2392
Timm17b	-3204

REACTOME_PEPTIDE_CHAIN_ELONGATION

REACTOME_PEPTIDE_CHAIN_ELONGATION
	168
set	REACTOME_PEPTIDE_CHAIN_ELONGATION
setSize	67
pANOVA	9.11e-12
s.dist	-0.482
p.adjustANOVA	8.62e-10

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rpl3	-4732
Rps20	-4731
Eef1a1	-4634
Rplp0	-4478
Rps16	-4388
Rps26	-4381
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rpl14	-4261
Rps14	-4156
Rpl27a	-4149
Rps18	-4084
Rpl32	-3930
Rps19	-3877
Rpl12	-3867
Rpl41	-3843
Rps27a	-3813
Rps27	-3774
Rps7	-3712

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rpl3	-4732.0
Rps20	-4731.0
Eef1a1	-4634.0
Rplp0	-4478.0
Rps16	-4388.0
Rps26	-4381.0
Rps3	-4305.0
Rps9	-4270.0
Rps15a	-4262.0
Rpl14	-4261.0
Rps14	-4156.0
Rpl27a	-4149.0
Rps18	-4084.0
Rpl32	-3930.0
Rps19	-3877.0
Rpl12	-3867.0
Rpl41	-3843.0
Rps27a	-3813.0
Rps27	-3774.0
Rps7	-3712.0
Rpl34	-3700.0
Rps6	-3544.0
Rpl19	-3518.0
Rpl8	-3455.0
Rps11	-3441.0
Rpl37a	-3426.0
Rpl4	-3422.0
Rpl39	-3347.0
Rps24	-3299.0
Rps8	-3189.0
Rpl5	-3184.0
Rps23	-3168.0
Rpl18	-3150.0
Rps25	-3145.0
Rps4x	-3135.0
Rps13	-3011.0
Rpl11	-2949.0
Rpl38	-2848.0
Rps21	-2572.0
Rpl23	-2441.0
Rpl30	-2322.0
Rpl28	-2306.0
Rps5	-2305.0
Rpsa	-2258.0
Rplp1	-2247.0
Rpl6	-2183.0
Rps3a1	-2117.0
Rpl22	-2013.0
Rpl23a	-1525.0
Rplp2	-1478.0
Rps17	-1380.0
Rpl18a	-1259.0
Rpl26	-1003.0
Eef2	-727.0
Rpl15	-441.0
Uba52	-372.0
Rpl24	-180.0
Rpl37	-151.0
Rpl29	171.0
Rps29	221.0
Rpl27-ps3	399.5
Rpl35	510.0
Rpl13	621.0
Rps12-ps3	679.0
Rpl10a	1174.0
Rpl36al	2581.0
Rpl3l	2902.0

REACTOME_COMPLEMENT_CASCADE

REACTOME_COMPLEMENT_CASCADE
	435
set	REACTOME_COMPLEMENT_CASCADE
setSize	11
pANOVA	0.00571
s.dist	-0.481
p.adjustANOVA	0.073

Top enriched genes

Top 20 genes
GeneID	Gene Rank
C3	-4547
C1qb	-4142
Cfd	-3915
C4b	-3770
C1qa	-3060
Pros1	-2966
Cr1l	-2755
C1s1	-1928
C1qc	-670
Cd46	-59
C7	681

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
C3	-4547
C1qb	-4142
Cfd	-3915
C4b	-3770
C1qa	-3060
Pros1	-2966
Cr1l	-2755
C1s1	-1928
C1qc	-670
Cd46	-59
C7	681

REACTOME_SIGNALING_BY_HIPPO

REACTOME_SIGNALING_BY_HIPPO
	65
set	REACTOME_SIGNALING_BY_HIPPO
setSize	15
pANOVA	0.00182
s.dist	-0.465
p.adjustANOVA	0.0278

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Yap1	-4667
Ywhab	-4382
Amotl2	-4133
Wwtr1	-4014
Lats2	-3950
Tjp1	-3559
Stk4	-2565
Ywhae	-2518
Sav1	-2324
Mob1b	-2205
Mob1a	-1819
Amot	-1736
Dvl2	-500
Amotl1	828
Lats1	1744

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Yap1	-4667
Ywhab	-4382
Amotl2	-4133
Wwtr1	-4014
Lats2	-3950
Tjp1	-3559
Stk4	-2565
Ywhae	-2518
Sav1	-2324
Mob1b	-2205
Mob1a	-1819
Amot	-1736
Dvl2	-500
Amotl1	828
Lats1	1744

REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION
	254
set	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION
setSize	10
pANOVA	0.0118
s.dist	-0.46
p.adjustANOVA	0.12

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cfl1	-4652
Plxna1	-4568
Fyn	-3900
Hsp90aa1	-3295
Rac1	-3156
Plxna2	-3109
Hsp90ab1	-3066
Pak2	-2776
Pak1	678
Nrp1	4207

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cfl1	-4652
Plxna1	-4568
Fyn	-3900
Hsp90aa1	-3295
Rac1	-3156
Plxna2	-3109
Hsp90ab1	-3066
Pak2	-2776
Pak1	678
Nrp1	4207

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE

REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
	348
set	REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE
setSize	13
pANOVA	0.00554
s.dist	-0.444
p.adjustANOVA	0.0727

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkcsh	-4768
Man1b1	-4430
Mlec	-4420
Calr	-4238
Edem1	-4220
Edem2	-3647
Mogs	-3632
Edem3	-3245
Ganab	-1907
Pdia3	-1403
Uggt1	1681
Uggt2	2203
Canx	2295

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkcsh	-4768
Man1b1	-4430
Mlec	-4420
Calr	-4238
Edem1	-4220
Edem2	-3647
Mogs	-3632
Edem3	-3245
Ganab	-1907
Pdia3	-1403
Uggt1	1681
Uggt2	2203
Canx	2295

REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE

REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
	56
set	REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
setSize	89
pANOVA	2.59e-11
s.dist	-0.41
p.adjustANOVA	2.04e-09

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sec11c	-4841
Rpl3	-4732
Rps20	-4731
Srp14	-4728
Rpn2	-4691
Rplp0	-4478
Sec61b	-4447
Rps16	-4388
Rps26	-4381
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rpl14	-4261
Rps14	-4156
Rpl27a	-4149
Rps18	-4084
Rpl32	-3930
Rps19	-3877
Rpl12	-3867
Rpl41	-3843

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sec11c	-4841.0
Rpl3	-4732.0
Rps20	-4731.0
Srp14	-4728.0
Rpn2	-4691.0
Rplp0	-4478.0
Sec61b	-4447.0
Rps16	-4388.0
Rps26	-4381.0
Rps3	-4305.0
Rps9	-4270.0
Rps15a	-4262.0
Rpl14	-4261.0
Rps14	-4156.0
Rpl27a	-4149.0
Rps18	-4084.0
Rpl32	-3930.0
Rps19	-3877.0
Rpl12	-3867.0
Rpl41	-3843.0
Rps27a	-3813.0
Rps27	-3774.0
Rps7	-3712.0
Rpl34	-3700.0
Rps6	-3544.0
Rpl19	-3518.0
Rpl8	-3455.0
Rps11	-3441.0
Rpl37a	-3426.0
Rpl4	-3422.0
Sec61a1	-3396.0
Rpl39	-3347.0
Rps24	-3299.0
Sec11a	-3263.0
Rps8	-3189.0
Rpl5	-3184.0
Rps23	-3168.0
Ddost	-3167.0
Rpl18	-3150.0
Rps25	-3145.0
Rps4x	-3135.0
Rps13	-3011.0
Rpl11	-2949.0
Rpl38	-2848.0
Srp9	-2715.0
Rps21	-2572.0
Ssr2	-2538.0
Rpn1	-2514.0
Rpl23	-2441.0
Rpl30	-2322.0
Rpl28	-2306.0
Rps5	-2305.0
Rpsa	-2258.0
Rplp1	-2247.0
Spcs3	-2221.0
Rpl6	-2183.0
Rps3a1	-2117.0
Rpl22	-2013.0
Tram1	-1946.0
Rpl23a	-1525.0
Rplp2	-1478.0
Rps17	-1380.0
Srprb	-1291.0
Rpl18a	-1259.0
Spcs2	-1216.0
Rpl26	-1003.0
Sec61a2	-720.0
Rpl15	-441.0
Uba52	-372.0
Ssr1	-340.0
Rpl24	-180.0
Ssr4	-175.0
Rpl37	-151.0
Rpl29	171.0
Rps29	221.0
Rpl27-ps3	399.5
Ssr3	475.0
Rpl35	510.0
Rpl13	621.0
Rps12-ps3	679.0
Rpl10a	1174.0
Srp68	1458.0
Srp72	1547.0
Srp19	1870.0
Rpl36al	2581.0
Sec61g	2813.0
Rpl3l	2902.0
Spcs1	3564.0
Srp54a	4616.0

REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR

REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR
	276
set	REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR
setSize	11
pANOVA	0.0237
s.dist	-0.394
p.adjustANOVA	0.181

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Jag2	-4372
Notch2	-4338
Dll1	-4188
Rps27a	-3813
Dll4	-3408
Adam10	-2887
Notch4	-2317
Jag1	-2302
Uba52	-372
Notch3	1457
Adam17	4064

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Jag2	-4372
Notch2	-4338
Dll1	-4188
Rps27a	-3813
Dll4	-3408
Adam10	-2887
Notch4	-2317
Jag1	-2302
Uba52	-372
Notch3	1457
Adam17	4064

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
	402
set	REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
setSize	83
pANOVA	9.77e-10
s.dist	-0.389
p.adjustANOVA	6.6e-08

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rpl3	-4732
Rps20	-4731
Rplp0	-4478
Rps16	-4388
Rps26	-4381
Dnajc3	-4309
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rpl14	-4261
Rps14	-4156
Rpl27a	-4149
Rps18	-4084
Rpl32	-3930
Rps19	-3877
Rpl12	-3867
Rpl41	-3843
Rps27a	-3813
Rps27	-3774
Rps7	-3712

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rpl3	-4732.0
Rps20	-4731.0
Rplp0	-4478.0
Rps16	-4388.0
Rps26	-4381.0
Dnajc3	-4309.0
Rps3	-4305.0
Rps9	-4270.0
Rps15a	-4262.0
Rpl14	-4261.0
Rps14	-4156.0
Rpl27a	-4149.0
Rps18	-4084.0
Rpl32	-3930.0
Rps19	-3877.0
Rpl12	-3867.0
Rpl41	-3843.0
Rps27a	-3813.0
Rps27	-3774.0
Rps7	-3712.0
Rpl34	-3700.0
Rps6	-3544.0
Rpl19	-3518.0
Rpl8	-3455.0
Rps11	-3441.0
Rpl37a	-3426.0
Rpl4	-3422.0
Rpl39	-3347.0
Rps24	-3299.0
Hsp90aa1	-3295.0
Rps8	-3189.0
Polr2a	-3186.0
Rpl5	-3184.0
Rps23	-3168.0
Rpl18	-3150.0
Rps25	-3145.0
Rps4x	-3135.0
Rps13	-3011.0
Rpl11	-2949.0
Rpl38	-2848.0
Rps21	-2572.0
Rpl23	-2441.0
Rpl30	-2322.0
Rpl28	-2306.0
Rps5	-2305.0
Rpsa	-2258.0
Rplp1	-2247.0
Rpl6	-2183.0
Rps3a1	-2117.0
Polr2h	-2056.0
Rpl22	-2013.0
Polr2j	-1908.0
Polr2e	-1896.0
Polr2g	-1865.0
Polr2c	-1533.0
Rpl23a	-1525.0
Rplp2	-1478.0
Rps17	-1380.0
Rpl18a	-1259.0
Rpl26	-1003.0
Polr2d	-504.0
Polr2l	-455.0
Rpl15	-441.0
Uba52	-372.0
Polr2k	-285.0
Rpl24	-180.0
Rpl37	-151.0
Polr2b	-31.0
Rpl29	171.0
Rps29	221.0
Rpl27-ps3	399.5
Polr2i	417.0
Rpl35	510.0
Rpl13	621.0
Rps12-ps3	679.0
Polr2f	1089.0
Rpl10a	1174.0
Gtf2f2	1844.0
Gtf2f1	2038.0
Rpl36al	2581.0
Rpl3l	2902.0
Ipo5	4340.0
Grsf1	4544.0

REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS
	66
set	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS
setSize	21
pANOVA	0.00245
s.dist	-0.382
p.adjustANOVA	0.0351

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dtx2	-4592
Dtx4	-4501
Arrb1	-4422
Jag2	-4372
Dll1	-4188
Rps27a	-3813
Dll4	-3408
Numb	-3201
Adam10	-2887
Arrb2	-2424
Jag1	-2302
Psen2	-2237
Mib1	-2120
Psenen	-1761
Mib2	-1522
Ncstn	-1228
Uba52	-372
Psen1	843
Aph1a	1189
Aph1b	1607

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dtx2	-4592
Dtx4	-4501
Arrb1	-4422
Jag2	-4372
Dll1	-4188
Rps27a	-3813
Dll4	-3408
Numb	-3201
Adam10	-2887
Arrb2	-2424
Jag1	-2302
Psen2	-2237
Mib1	-2120
Psenen	-1761
Mib2	-1522
Ncstn	-1228
Uba52	-372
Psen1	843
Aph1a	1189
Aph1b	1607
Adam17	4064

REACTOME_CALNEXIN_CALRETICULIN_CYCLE

REACTOME_CALNEXIN_CALRETICULIN_CYCLE
	344
set	REACTOME_CALNEXIN_CALRETICULIN_CYCLE
setSize	11
pANOVA	0.0295
s.dist	-0.379
p.adjustANOVA	0.202

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkcsh	-4768
Man1b1	-4430
Calr	-4238
Edem1	-4220
Edem2	-3647
Edem3	-3245
Ganab	-1907
Pdia3	-1403
Uggt1	1681
Uggt2	2203
Canx	2295

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkcsh	-4768
Man1b1	-4430
Calr	-4238
Edem1	-4220
Edem2	-3647
Edem3	-3245
Ganab	-1907
Pdia3	-1403
Uggt1	1681
Uggt2	2203
Canx	2295

REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING
	255
set	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING
setSize	23
pANOVA	0.00216
s.dist	-0.37
p.adjustANOVA	0.0319

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Arhgef11	-4928
Ptprc	-4832
Rac2	-4775
Myl12b	-4774
Myh9	-4692
Rhog	-4459
Arhgap35	-4212
Limk2	-4203
Sema4d	-3775
Rac1	-3156
Rock1	-3084
Rras	-3069
Met	-2806
Rhob	-2275
Cdc42	-1959
Myl6	-652
Rhoc	-570
Myh11	-454
Myh14	1285
Rock2	1956

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Arhgef11	-4928
Ptprc	-4832
Rac2	-4775
Myl12b	-4774
Myh9	-4692
Rhog	-4459
Arhgap35	-4212
Limk2	-4203
Sema4d	-3775
Rac1	-3156
Rock1	-3084
Rras	-3069
Met	-2806
Rhob	-2275
Cdc42	-1959
Myl6	-652
Rhoc	-570
Myh11	-454
Myh14	1285
Rock2	1956
Myl9	2592
Myh10	4213
Arhgef12	4407

REACTOME_SIGNALING_BY_NOTCH2

REACTOME_SIGNALING_BY_NOTCH2
	73
set	REACTOME_SIGNALING_BY_NOTCH2
setSize	12
pANOVA	0.0268
s.dist	-0.369
p.adjustANOVA	0.195

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Jag2	-4372
Notch2	-4338
Dll1	-4188
Dll4	-3408
Adam10	-2887
Jag1	-2302
Psen2	-2237
Psenen	-1761
Ncstn	-1228
Psen1	843
Aph1a	1189
Aph1b	1607

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Jag2	-4372
Notch2	-4338
Dll1	-4188
Dll4	-3408
Adam10	-2887
Jag1	-2302
Psen2	-2237
Psenen	-1761
Ncstn	-1228
Psen1	843
Aph1a	1189
Aph1b	1607

REACTOME_SOS_MEDIATED_SIGNALLING

REACTOME_SOS_MEDIATED_SIGNALLING
	396
set	REACTOME_SOS_MEDIATED_SIGNALLING
setSize	13
pANOVA	0.0214
s.dist	-0.369
p.adjustANOVA	0.169

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ywhab	-4382
Irs1	-4185
Grb2	-4182
Irs2	-3730
Raf1	-3169
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Map2k2	-1603
Mapk3	-1435
Hras	198
Sos1	1814
Kras	2923

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ywhab	-4382
Irs1	-4185
Grb2	-4182
Irs2	-3730
Raf1	-3169
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Map2k2	-1603
Mapk3	-1435
Hras	198
Sos1	1814
Kras	2923

REACTOME_RAP1_SIGNALLING

REACTOME_RAP1_SIGNALLING
	352
set	REACTOME_RAP1_SIGNALLING
setSize	12
pANOVA	0.0274
s.dist	-0.368
p.adjustANOVA	0.196

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sipa1	-4968
Prkacb	-4780
Ywhab	-4382
Rasgrp2	-3818
Rapgef3	-3640
Rap1a	-3523
Rap1b	-3268
Raf1	-3169
Prkaca	137
Rap1gap2	511
Rap1gap	3819
Prkg1	4086

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sipa1	-4968
Prkacb	-4780
Ywhab	-4382
Rasgrp2	-3818
Rapgef3	-3640
Rap1a	-3523
Rap1b	-3268
Raf1	-3169
Prkaca	137
Rap1gap2	511
Rap1gap	3819
Prkg1	4086

REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING

REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
	194
set	REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING
setSize	18
pANOVA	0.0075
s.dist	-0.364
p.adjustANOVA	0.0865

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Csk	-4881
Syk	-4858
Vwf	-4707
Grb2	-4182
Rasgrp2	-3818
Rapgef3	-3640
Rap1a	-3523
Akt1	-3392
Rap1b	-3268
Ptpn1	-2296
Shc1	-2069
Bcar1	-1371
Ptk2	-1239
Crk	975
Fn1	1084
Sos1	1814
Pdpk1	2503
Tln1	2719

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Csk	-4881
Syk	-4858
Vwf	-4707
Grb2	-4182
Rasgrp2	-3818
Rapgef3	-3640
Rap1a	-3523
Akt1	-3392
Rap1b	-3268
Ptpn1	-2296
Shc1	-2069
Bcar1	-1371
Ptk2	-1239
Crk	975
Fn1	1084
Sos1	1814
Pdpk1	2503
Tln1	2719

REACTOME_GLUTATHIONE_CONJUGATION

REACTOME_GLUTATHIONE_CONJUGATION
	434
set	REACTOME_GLUTATHIONE_CONJUGATION
setSize	12
pANOVA	0.0308
s.dist	0.36
p.adjustANOVA	0.206

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mgst1	4321
Gss	4084
Gsto1	3795
Mgst3	3685
Oplah	3009
Gclc	2989
Gstm4	2100
Gclm	555
Ggct	-430
Gstm2	-1081
Gstp1	-1560
Cndp2	-2137

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mgst1	4321
Gss	4084
Gsto1	3795
Mgst3	3685
Oplah	3009
Gclc	2989
Gstm4	2100
Gclm	555
Ggct	-430
Gstm2	-1081
Gstp1	-1560
Cndp2	-2137

REACTOME_PEROXISOMAL_LIPID_METABOLISM

REACTOME_PEROXISOMAL_LIPID_METABOLISM
	210
set	REACTOME_PEROXISOMAL_LIPID_METABOLISM
setSize	16
pANOVA	0.0138
s.dist	0.356
p.adjustANOVA	0.131

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Scp2	4443
Phyh	4412
Idh1	4204
Hacl1	4101
Acox1	3652
Crat	3605
Gnpat	3133
Hsd17b4	2799
Abcd1	2135
Agps	1978
Amacr	1535
Slc25a17	393
Acox3	-1567
Acot8	-1952
Crot	-2644
Far1	-4808

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Scp2	4443
Phyh	4412
Idh1	4204
Hacl1	4101
Acox1	3652
Crat	3605
Gnpat	3133
Hsd17b4	2799
Abcd1	2135
Agps	1978
Amacr	1535
Slc25a17	393
Acox3	-1567
Acot8	-1952
Crot	-2644
Far1	-4808

REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX

REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
	449
set	REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
setSize	85
pANOVA	2.01e-08
s.dist	-0.353
p.adjustANOVA	1.05e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rpl3	-4732
Rps20	-4731
Rplp0	-4478
Ppp2r2a	-4393
Rps16	-4388
Rps26	-4381
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rpl14	-4261
Rps14	-4156
Rpl27a	-4149
Rps18	-4084
Rpl32	-3930
Rps19	-3877
Rpl12	-3867
Rpl41	-3843
Rps27a	-3813
Rps27	-3774
Rps7	-3712

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rpl3	-4732.0
Rps20	-4731.0
Rplp0	-4478.0
Ppp2r2a	-4393.0
Rps16	-4388.0
Rps26	-4381.0
Rps3	-4305.0
Rps9	-4270.0
Rps15a	-4262.0
Rpl14	-4261.0
Rps14	-4156.0
Rpl27a	-4149.0
Rps18	-4084.0
Rpl32	-3930.0
Rps19	-3877.0
Rpl12	-3867.0
Rpl41	-3843.0
Rps27a	-3813.0
Rps27	-3774.0
Rps7	-3712.0
Rpl34	-3700.0
Rps6	-3544.0
Rpl19	-3518.0
Smg6	-3512.0
Rpl8	-3455.0
Rps11	-3441.0
Rpl37a	-3426.0
Rpl4	-3422.0
Eif4a3	-3361.0
Rpl39	-3347.0
Rps24	-3299.0
Rps8	-3189.0
Rpl5	-3184.0
Rps23	-3168.0
Rpl18	-3150.0
Rps25	-3145.0
Rps4x	-3135.0
Rps13	-3011.0
Rpl11	-2949.0
Rpl38	-2848.0
Rps21	-2572.0
Rpl23	-2441.0
Rpl30	-2322.0
Rpl28	-2306.0
Rps5	-2305.0
Rpsa	-2258.0
Rplp1	-2247.0
Rpl6	-2183.0
Rps3a1	-2117.0
Rpl22	-2013.0
Upf3a	-1984.0
Smg5	-1530.0
Rpl23a	-1525.0
Rplp2	-1478.0
Rps17	-1380.0
Rnps1	-1266.0
Rpl18a	-1259.0
Smg7	-1248.0
Rpl26	-1003.0
Ppp2r1a	-533.0
Smg8	-523.0
Eif4g1	-452.0
Rpl15	-441.0
Uba52	-372.0
Rpl24	-180.0
Rpl37	-151.0
Ncbp1	-23.0
Magoh	98.0
Rpl29	171.0
Rps29	221.0
Rpl27-ps3	399.5
Rpl35	510.0
Rpl13	621.0
Rps12-ps3	679.0
Rpl10a	1174.0
Upf2	1341.0
Casc3	2042.0
Smg9	2110.0
Etf1	2185.0
Rpl36al	2581.0
Rpl3l	2902.0
Upf3b	3443.0
Smg1	3444.0
Ncbp2	3469.0
Ppp2ca	4394.0

REACTOME_SIGNALING_BY_ROBO_RECEPTOR

REACTOME_SIGNALING_BY_ROBO_RECEPTOR
	266
set	REACTOME_SIGNALING_BY_ROBO_RECEPTOR
setSize	20
pANOVA	0.00646
s.dist	-0.352
p.adjustANOVA	0.0804

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Vasp	-4962
Nck2	-4956
Abl1	-4948
Cap1	-4588
Pfn2	-4427
Srgap2	-4096
Pfn1	-3666
Evl	-3238
Rac1	-3156
Pak2	-2776
Cdc42	-1959
Gpc1	-1681
Sos2	-1407
Enah	-1347
Cap2	345
Pak1	678
Sos1	1814
Nck1	1829
Abl2	2739
Clasp1	3049

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Vasp	-4962
Nck2	-4956
Abl1	-4948
Cap1	-4588
Pfn2	-4427
Srgap2	-4096
Pfn1	-3666
Evl	-3238
Rac1	-3156
Pak2	-2776
Cdc42	-1959
Gpc1	-1681
Sos2	-1407
Enah	-1347
Cap2	345
Pak1	678
Sos1	1814
Nck1	1829
Abl2	2739
Clasp1	3049

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
	9
set	REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
setSize	42
pANOVA	0.000132
s.dist	-0.341
p.adjustANOVA	0.0026

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps20	-4731
Rps16	-4388
Rps26	-4381
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rps14	-4156
Rps18	-4084
Rps19	-3877
Rps27a	-3813
Rps27	-3774
Rps7	-3712
Rps6	-3544
Rps11	-3441
Rps24	-3299
Rps8	-3189
Eif3f	-3173
Rps23	-3168
Rps25	-3145
Rps4x	-3135

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps20	-4731
Rps16	-4388
Rps26	-4381
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rps14	-4156
Rps18	-4084
Rps19	-3877
Rps27a	-3813
Rps27	-3774
Rps7	-3712
Rps6	-3544
Rps11	-3441
Rps24	-3299
Rps8	-3189
Eif3f	-3173
Rps23	-3168
Rps25	-3145
Rps4x	-3135
Rps13	-3011
Rps21	-2572
Rps5	-2305
Rpsa	-2258
Rps3a1	-2117
Eif3e	-1937
Eif2s1	-1630
Eif1ax	-1559
Eif3h	-1512
Rps17	-1380
Eif3d	-711
Eif3b	-577
Eif3j2	-448
Rps29	221
Rps12-ps3	679
Eif3k	1422
Eif2s3x	2714
Eif3i	2780
Eif2s2	3333
Eif3g	3362
Eif3c	4072
Eif3a	4439

REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP

REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP
	364
set	REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP
setSize	14
pANOVA	0.028
s.dist	-0.339
p.adjustANOVA	0.196

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Exosc7	-4635
Dcp2	-4299
Exosc5	-4057
Akt1	-3392
Exosc1	-3064
Parn	-2545
Khsrp	-2323
Exosc2	-2138
Mapk14	-1473
Exosc4	-666
Exosc8	-260
Dis3	851
Exosc9	1312
Exosc3	1805

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Exosc7	-4635
Dcp2	-4299
Exosc5	-4057
Akt1	-3392
Exosc1	-3064
Parn	-2545
Khsrp	-2323
Exosc2	-2138
Mapk14	-1473
Exosc4	-666
Exosc8	-260
Dis3	851
Exosc9	1312
Exosc3	1805

REACTOME_SIGNALING_BY_NOTCH4

REACTOME_SIGNALING_BY_NOTCH4
	67
set	REACTOME_SIGNALING_BY_NOTCH4
setSize	12
pANOVA	0.0448
s.dist	-0.335
p.adjustANOVA	0.264

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Jag2	-4372
Dll1	-4188
Dll4	-3408
Adam10	-2887
Notch4	-2317
Jag1	-2302
Psen2	-2237
Psenen	-1761
Ncstn	-1228
Psen1	843
Aph1a	1189
Aph1b	1607

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Jag2	-4372
Dll1	-4188
Dll4	-3408
Adam10	-2887
Notch4	-2317
Jag1	-2302
Psen2	-2237
Psenen	-1761
Ncstn	-1228
Psen1	843
Aph1a	1189
Aph1b	1607

REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION

REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
	181
set	REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
setSize	22
pANOVA	0.00693
s.dist	0.333
p.adjustANOVA	0.0819

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Eprs	4307
Lars	3944
Sars	3709
Aars	3669
Cars	3666
Yars	3661
Dars	3476
Iars	3473
Farsb	3377
Kars	3171
Aimp2	2814
Rars	2644
Nars	2554
Aimp1	1922
Ppa1	260
Wars	-638
Hars	-682
Tars	-928
Gars	-1989
Qars	-2868

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Eprs	4307
Lars	3944
Sars	3709
Aars	3669
Cars	3666
Yars	3661
Dars	3476
Iars	3473
Farsb	3377
Kars	3171
Aimp2	2814
Rars	2644
Nars	2554
Aimp1	1922
Ppa1	260
Wars	-638
Hars	-682
Tars	-928
Gars	-1989
Qars	-2868
Farsa	-3492
Vars	-3571

REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING

REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
	58
set	REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
setSize	13
pANOVA	0.0417
s.dist	-0.326
p.adjustANOVA	0.253

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ywhab	-4382
Grb2	-4182
Hbegf	-3179
Raf1	-3169
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Shc1	-2069
Map2k2	-1603
Mapk3	-1435
Hras	198
Sos1	1814
Kras	2923

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ywhab	-4382
Grb2	-4182
Hbegf	-3179
Raf1	-3169
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Shc1	-2069
Map2k2	-1603
Mapk3	-1435
Hras	198
Sos1	1814
Kras	2923

REACTOME_TELOMERE_MAINTENANCE

REACTOME_TELOMERE_MAINTENANCE
	455
set	REACTOME_TELOMERE_MAINTENANCE
setSize	20
pANOVA	0.0142
s.dist	-0.317
p.adjustANOVA	0.131

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pcna	-4878
Terf2	-4056
Ruvbl1	-4026
Terf2ip	-3449
Pold4	-3445
Pold3	-2822
Pold2	-2568
Ruvbl2	-2272
Nhp2	-1960
Acd	-1792
Rfc2	-1455
Pola2	-1424
Tinf2	-1155
Pot1a	-1044
Dkc1	-645
Rfc4	-598
Rpa1	-524
Rpa2	241
Pold1	1272
Wrap53	3234

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pcna	-4878
Terf2	-4056
Ruvbl1	-4026
Terf2ip	-3449
Pold4	-3445
Pold3	-2822
Pold2	-2568
Ruvbl2	-2272
Nhp2	-1960
Acd	-1792
Rfc2	-1455
Pola2	-1424
Tinf2	-1155
Pot1a	-1044
Dkc1	-645
Rfc4	-598
Rpa1	-524
Rpa2	241
Pold1	1272
Wrap53	3234

REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING
	54
set	REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING
setSize	14
pANOVA	0.0404
s.dist	-0.317
p.adjustANOVA	0.251

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ywhab	-4382
Grb2	-4182
Hbegf	-3179
Raf1	-3169
Egf	-2942
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Map2k2	-1603
Mapk3	-1435
Egfr	-174
Hras	198
Sos1	1814
Kras	2923

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ywhab	-4382
Grb2	-4182
Hbegf	-3179
Raf1	-3169
Egf	-2942
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Map2k2	-1603
Mapk3	-1435
Egfr	-174
Hras	198
Sos1	1814
Kras	2923

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
	232
set	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
setSize	16
pANOVA	0.0314
s.dist	-0.311
p.adjustANOVA	0.206

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Myo6	-4658
Mdm2	-4225
Camk2d	-3839
Grip2	-3740
Ap2a1	-3327
Camk2a	-3194
Ap2s1	-2770
Dlg1	-2557
Ap2a2	-2043
Epb41l1	-1903
Prkca	-833
Camk2b	-309
Nsf	364
Pick1	1137
Ap2m1	2348
Ap2b1	3313

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Myo6	-4658
Mdm2	-4225
Camk2d	-3839
Grip2	-3740
Ap2a1	-3327
Camk2a	-3194
Ap2s1	-2770
Dlg1	-2557
Ap2a2	-2043
Epb41l1	-1903
Prkca	-833
Camk2b	-309
Nsf	364
Pick1	1137
Ap2m1	2348
Ap2b1	3313

REACTOME_SEMAPHORIN_INTERACTIONS

REACTOME_SEMAPHORIN_INTERACTIONS
	256
set	REACTOME_SEMAPHORIN_INTERACTIONS
setSize	44
pANOVA	0.000379
s.dist	-0.31
p.adjustANOVA	0.0064

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Arhgef11	-4928
Plxnd1	-4835
Ptprc	-4832
Rac2	-4775
Myl12b	-4774
Myh9	-4692
Cfl1	-4652
Sema6d	-4647
Plxna1	-4568
Rhog	-4459
Arhgap35	-4212
Limk2	-4203
Fyn	-3900
Sema4d	-3775
Hsp90aa1	-3295
Rac1	-3156
Plxna2	-3109
Rock1	-3084
Rras	-3069
Hsp90ab1	-3066

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Arhgef11	-4928
Plxnd1	-4835
Ptprc	-4832
Rac2	-4775
Myl12b	-4774
Myh9	-4692
Cfl1	-4652
Sema6d	-4647
Plxna1	-4568
Rhog	-4459
Arhgap35	-4212
Limk2	-4203
Fyn	-3900
Sema4d	-3775
Hsp90aa1	-3295
Rac1	-3156
Plxna2	-3109
Rock1	-3084
Rras	-3069
Hsp90ab1	-3066
Pip5k1c	-2992
Dpysl3	-2827
Sema7a	-2819
Met	-2806
Pak2	-2776
Rhob	-2275
Cdc42	-1959
Dpysl2	-871
Myl6	-652
Rhoc	-570
Myh11	-454
Sema6a	-226
Itga1	401
Pak1	678
Myh14	1285
Rock2	1956
Cdk5	2343
Farp2	2579
Myl9	2592
Tln1	2719
Itgb1	4122
Nrp1	4207
Myh10	4213
Arhgef12	4407

REACTOME_STRIATED_MUSCLE_CONTRACTION

REACTOME_STRIATED_MUSCLE_CONTRACTION
	212
set	REACTOME_STRIATED_MUSCLE_CONTRACTION
setSize	22
pANOVA	0.0122
s.dist	0.309
p.adjustANOVA	0.12

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mybpc1	4530
Neb	4351
Tpm2	4209
Actn2	4143
Myl2	3312
Myl4	3274
Tcap	3224
Myl3	2746
Dmd	2022
Des	1657
Tnnt1	1025
Tnni2	893
Tnnc2	865
Vim	737
Tnni1	23
Tnnc1	-62
Myl1	-262
Tpm3	-360
Tmod1	-1049
Tpm4	-1313

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mybpc1	4530
Neb	4351
Tpm2	4209
Actn2	4143
Myl2	3312
Myl4	3274
Tcap	3224
Myl3	2746
Dmd	2022
Des	1657
Tnnt1	1025
Tnni2	893
Tnnc2	865
Vim	737
Tnni1	23
Tnnc1	-62
Myl1	-262
Tpm3	-360
Tmod1	-1049
Tpm4	-1313
Tpm1	-1988
Mybpc2	-2049

REACTOME_LAGGING_STRAND_SYNTHESIS

REACTOME_LAGGING_STRAND_SYNTHESIS
	386
set	REACTOME_LAGGING_STRAND_SYNTHESIS
setSize	10
pANOVA	0.0932
s.dist	-0.307
p.adjustANOVA	0.427

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pcna	-4878
Pold4	-3445
Pold3	-2822
Pold2	-2568
Rfc2	-1455
Pola2	-1424
Rfc4	-598
Rpa1	-524
Rpa2	241
Pold1	1272

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pcna	-4878
Pold4	-3445
Pold3	-2822
Pold2	-2568
Rfc2	-1455
Pola2	-1424
Rfc4	-598
Rpa1	-524
Rpa2	241
Pold1	1272

REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION

REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
	220
set	REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
setSize	86
pANOVA	1.1e-06
s.dist	-0.305
p.adjustANOVA	3.72e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rpl3	-4732
Rps20	-4731
Rplp0	-4478
Rps16	-4388
Rps26	-4381
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rpl14	-4261
Rps14	-4156
Rpl27a	-4149
Rps18	-4084
Rpl32	-3930
Rps19	-3877
Rpl12	-3867
Rpl41	-3843
Rps27a	-3813
Rps27	-3774
Rps7	-3712
Rpl34	-3700

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rpl3	-4732.0
Rps20	-4731.0
Rplp0	-4478.0
Rps16	-4388.0
Rps26	-4381.0
Rps3	-4305.0
Rps9	-4270.0
Rps15a	-4262.0
Rpl14	-4261.0
Rps14	-4156.0
Rpl27a	-4149.0
Rps18	-4084.0
Rpl32	-3930.0
Rps19	-3877.0
Rpl12	-3867.0
Rpl41	-3843.0
Rps27a	-3813.0
Rps27	-3774.0
Rps7	-3712.0
Rpl34	-3700.0
Rps6	-3544.0
Rpl19	-3518.0
Rpl8	-3455.0
Rps11	-3441.0
Rpl37a	-3426.0
Rpl4	-3422.0
Rpl39	-3347.0
Rps24	-3299.0
Rps8	-3189.0
Rpl5	-3184.0
Eif3f	-3173.0
Rps23	-3168.0
Rpl18	-3150.0
Rps25	-3145.0
Rps4x	-3135.0
Rps13	-3011.0
Rpl11	-2949.0
Rpl38	-2848.0
Rps21	-2572.0
Rpl23	-2441.0
Rpl30	-2322.0
Rpl28	-2306.0
Rps5	-2305.0
Rpsa	-2258.0
Rplp1	-2247.0
Rpl6	-2183.0
Rps3a1	-2117.0
Rpl22	-2013.0
Eif3e	-1937.0
Eif2s1	-1630.0
Eif1ax	-1559.0
Rpl23a	-1525.0
Eif3h	-1512.0
Rplp2	-1478.0
Rps17	-1380.0
Rpl18a	-1259.0
Rpl26	-1003.0
Eif3d	-711.0
Eif3b	-577.0
Eif4g1	-452.0
Eif3j2	-448.0
Rpl15	-441.0
Uba52	-372.0
Rpl24	-180.0
Rpl37	-151.0
Rpl29	171.0
Rps29	221.0
Rpl27-ps3	399.5
Rpl35	510.0
Rpl13	621.0
Rps12-ps3	679.0
Eif4h	1016.0
Eif4a1	1121.0
Rpl10a	1174.0
Eif3k	1422.0
Eif4b	2476.0
Rpl36al	2581.0
Eif2s3x	2714.0
Eif3i	2780.0
Eif4a2	2899.0
Rpl3l	2902.0
Eif2s2	3333.0
Eif3g	3362.0
Eif3c	4072.0
Eif4e	4162.0
Eif3a	4439.0

REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION
	95
set	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION
setSize	20
pANOVA	0.019
s.dist	-0.303
p.adjustANOVA	0.164

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Men1	-4794
Tgif1	-4607
Hdac1	-4503
Cdk8	-4316
Wwtr1	-4014
Rps27a	-3813
Junb	-3517
Bmyc	-3465
Cdk9	-2608
Smad7	-2197
E2f4	-1650
Tfdp1	-1161
Smad4	-1156
Uba52	-372
Ccnc	943
Ccnt1	1225
Smad2	1311
Smad3	1507
Ccnt2	2421
Sp1	2747

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Men1	-4794
Tgif1	-4607
Hdac1	-4503
Cdk8	-4316
Wwtr1	-4014
Rps27a	-3813
Junb	-3517
Bmyc	-3465
Cdk9	-2608
Smad7	-2197
E2f4	-1650
Tfdp1	-1161
Smad4	-1156
Uba52	-372
Ccnc	943
Ccnt1	1225
Smad2	1311
Smad3	1507
Ccnt2	2421
Sp1	2747

REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1

REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1
	355
set	REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1
setSize	16
pANOVA	0.0372
s.dist	-0.301
p.adjustANOVA	0.235

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Exosc7	-4635
Ywhab	-4382
Zfp36l1	-4366
Dcp2	-4299
Exosc5	-4057
Dcp1a	-3652
Akt1	-3392
Exosc1	-3064
Exosc2	-2138
Exosc4	-666
Exosc8	-260
Dis3	851
Xrn1	948
Exosc9	1312
Exosc3	1805
Mapkapk2	4535

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Exosc7	-4635
Ywhab	-4382
Zfp36l1	-4366
Dcp2	-4299
Exosc5	-4057
Dcp1a	-3652
Akt1	-3392
Exosc1	-3064
Exosc2	-2138
Exosc4	-666
Exosc8	-260
Dis3	851
Xrn1	948
Exosc9	1312
Exosc3	1805
Mapkapk2	4535

REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING

REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING
	142
set	REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING
setSize	14
pANOVA	0.0519
s.dist	-0.3
p.adjustANOVA	0.292

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ywhab	-4382
Grb2	-4182
Raf1	-3169
Egf	-2942
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Shc1	-2069
Map2k2	-1603
Mapk3	-1435
Egfr	-174
Hras	198
Sos1	1814
Kras	2923

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ywhab	-4382
Grb2	-4182
Raf1	-3169
Egf	-2942
Mapk1	-2690
Map2k1	-2327
Nras	-2190
Shc1	-2069
Map2k2	-1603
Mapk3	-1435
Egfr	-174
Hras	198
Sos1	1814
Kras	2923

REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION

REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION
	384
set	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION
setSize	19
pANOVA	0.0237
s.dist	-0.3
p.adjustANOVA	0.181

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Csk	-4881
Syk	-4858
Vwf	-4707
Grb2	-4182
Rasgrp2	-3818
Rapgef3	-3640
Rap1a	-3523
Akt1	-3392
Rap1b	-3268
Ptpn1	-2296
Shc1	-2069
Bcar1	-1371
Ptk2	-1239
Crk	975
Fn1	1084
Sos1	1814
Pdpk1	2503
Tln1	2719
Thpo	4027

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Csk	-4881
Syk	-4858
Vwf	-4707
Grb2	-4182
Rasgrp2	-3818
Rapgef3	-3640
Rap1a	-3523
Akt1	-3392
Rap1b	-3268
Ptpn1	-2296
Shc1	-2069
Bcar1	-1371
Ptk2	-1239
Crk	975
Fn1	1084
Sos1	1814
Pdpk1	2503
Tln1	2719
Thpo	4027

REACTOME_INFLUENZA_LIFE_CYCLE

REACTOME_INFLUENZA_LIFE_CYCLE
	401
set	REACTOME_INFLUENZA_LIFE_CYCLE
setSize	115
pANOVA	6.07e-08
s.dist	-0.293
p.adjustANOVA	2.61e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nup93	-4831
Rpl3	-4732
Rps20	-4731
Rplp0	-4478
Kpnb1	-4433
Rps16	-4388
Rps26	-4381
Nup85	-4341
Dnajc3	-4309
Rps3	-4305
Rps9	-4270
Rps15a	-4262
Rpl14	-4261
Calr	-4238
Hspa1b	-4229
Rps14	-4156
Rpl27a	-4149
Rps18	-4084
Rpl32	-3930
Rps19	-3877

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nup93	-4831.0
Rpl3	-4732.0
Rps20	-4731.0
Rplp0	-4478.0
Kpnb1	-4433.0
Rps16	-4388.0
Rps26	-4381.0
Nup85	-4341.0
Dnajc3	-4309.0
Rps3	-4305.0
Rps9	-4270.0
Rps15a	-4262.0
Rpl14	-4261.0
Calr	-4238.0
Hspa1b	-4229.0
Rps14	-4156.0
Rpl27a	-4149.0
Rps18	-4084.0
Rpl32	-3930.0
Rps19	-3877.0
Rpl12	-3867.0
Rpl41	-3843.0
Rps27a	-3813.0
Rps27	-3774.0
Rps7	-3712.0
Rpl34	-3700.0
Rps6	-3544.0
Rpl19	-3518.0
Rpl8	-3455.0
Rps11	-3441.0
Rpl37a	-3426.0
Rpl4	-3422.0
Rpl39	-3347.0
Ran	-3341.0
Rps24	-3299.0
Hsp90aa1	-3295.0
Rps8	-3189.0
Polr2a	-3186.0
Rpl5	-3184.0
Rps23	-3168.0
Rpl18	-3150.0
Rps25	-3145.0
Rps4x	-3135.0
Nup43	-3094.0
Rps13	-3011.0
Rpl11	-2949.0
Rpl38	-2848.0
Nup188	-2574.0
Rps21	-2572.0
Rpl23	-2441.0
Rpl30	-2322.0
Rpl28	-2306.0
Rps5	-2305.0
Nup214	-2265.0
Rpsa	-2258.0
Rplp1	-2247.0
Rpl6	-2183.0
Rps3a1	-2117.0
Polr2h	-2056.0
Rpl22	-2013.0
Clta	-1929.0
Polr2j	-1908.0
Polr2e	-1896.0
Polr2g	-1865.0
Aaas	-1613.0
Polr2c	-1533.0
Rpl23a	-1525.0
Pom121	-1511.0
Rplp2	-1478.0
Nup153	-1471.0
Rps17	-1380.0
Rpl18a	-1259.0
Rpl26	-1003.0
Xpo1	-888.0
Nup35	-821.0
Polr2d	-504.0
Polr2l	-455.0
Rpl15	-441.0
Uba52	-372.0
Polr2k	-285.0
Rpl24	-180.0
Rpl37	-151.0
Polr2b	-31.0
Nup107	24.0
Rpl29	171.0
Rps29	221.0
Nup155	369.0
Rpl27-ps3	399.5
Polr2i	417.0
Ranbp2	452.0
Rpl35	510.0
Rpl13	621.0
Nup205	668.0
Rps12-ps3	679.0
Nup54	1007.0
Polr2f	1089.0
Nup133	1108.0
Rpl10a	1174.0
Rae1	1589.0
Nupl2	1617.0
Seh1l	1813.0
Gtf2f2	1844.0
Gtf2f1	2038.0
Nup210	2093.0
Nup88	2094.0
Kpna1	2267.0
Canx	2295.0
Nup62	2535.0
Rpl36al	2581.0
Cltc	2849.0
Rpl3l	2902.0
Nup37	3867.0
Tpr	4206.0
Ipo5	4340.0
Grsf1	4544.0

REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE
	257
set	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE
setSize	19
pANOVA	0.0282
s.dist	-0.291
p.adjustANOVA	0.196

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Arhgef11	-4928
Rac2	-4775
Myl12b	-4774
Myh9	-4692
Rhog	-4459
Limk2	-4203
Sema4d	-3775
Rac1	-3156
Rock1	-3084
Rhob	-2275
Cdc42	-1959
Myl6	-652
Rhoc	-570
Myh11	-454
Myh14	1285
Rock2	1956
Myl9	2592
Myh10	4213
Arhgef12	4407

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Arhgef11	-4928
Rac2	-4775
Myl12b	-4774
Myh9	-4692
Rhog	-4459
Limk2	-4203
Sema4d	-3775
Rac1	-3156
Rock1	-3084
Rhob	-2275
Cdc42	-1959
Myl6	-652
Rhoc	-570
Myh11	-454
Myh14	1285
Rock2	1956
Myl9	2592
Myh10	4213
Arhgef12	4407

REACTOME_REGULATION_OF_KIT_SIGNALING

REACTOME_REGULATION_OF_KIT_SIGNALING
	34
set	REACTOME_REGULATION_OF_KIT_SIGNALING
setSize	11
pANOVA	0.0975
s.dist	-0.289
p.adjustANOVA	0.431

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ptpn6	-4888
Lyn	-4785
Cbl	-4529
Grb2	-4182
Fyn	-3900
Sh2b3	-2910
Prkca	-833
Kitl	1652
Sos1	1814
Yes1	2111
Socs6	3591

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ptpn6	-4888
Lyn	-4785
Cbl	-4529
Grb2	-4182
Fyn	-3900
Sh2b3	-2910
Prkca	-833
Kitl	1652
Sos1	1814
Yes1	2111
Socs6	3591

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports