Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-09-07
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## stat
## 0610009B22Rik 0.3047981
## 0610009L18Rik -0.2679990
## 0610010K14Rik -0.7218075
## 0610012G03Rik -0.1786497
## 0610030E20Rik -0.4541127
## 0610040J01Rik -1.3376144| Profile metrics | |
|---|---|
| num_genesets | 674 |
| num_genes_in_profile | 9337 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 2785 |
| num_profile_genes_not_in_sets | 6552 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes.
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 674 |
| num_genesets_excluded | 206 |
| num_genesets_included | 468 |
Differential pathway expression
Interactive enrichment scatterplot
Significance is calculated by -log10(p-value). All points shown are FDR<0.05.
Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.
Results table
Top N= 50 gene sets| set | setSize | pANOVA | s.dist | p.adjustANOVA |
|---|---|---|---|---|
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 4.16e-04 | 0.615 | 4.14e-03 |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 40 | 2.02e-07 | 0.475 | 1.76e-05 |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 42 | 1.53e-07 | 0.468 | 1.76e-05 |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 40 | 3.58e-07 | 0.465 | 1.76e-05 |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 42 | 3.49e-07 | 0.455 | 1.76e-05 |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 42 | 3.77e-07 | 0.453 | 1.76e-05 |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 45 | 2.84e-07 | 0.443 | 1.76e-05 |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 43 | 8.27e-07 | 0.435 | 2.85e-05 |
| REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 14 | 4.91e-03 | 0.434 | 3.15e-02 |
| REACTOME ER PHAGOSOME PATHWAY | 48 | 2.10e-07 | 0.433 | 1.76e-05 |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 42 | 1.26e-06 | 0.432 | 3.48e-05 |
| REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 13 | 6.97e-03 | -0.432 | 3.98e-02 |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 10 | 2.34e-02 | -0.414 | 9.95e-02 |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 48 | 9.23e-07 | 0.410 | 2.88e-05 |
| REACTOME SIGNALING BY NOTCH4 | 11 | 1.89e-02 | -0.409 | 8.34e-02 |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 49 | 9.92e-07 | 0.404 | 2.90e-05 |
| REACTOME SIGNALING BY NOTCH3 | 11 | 2.08e-02 | -0.403 | 9.03e-02 |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 43 | 5.35e-06 | 0.401 | 1.25e-04 |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 56 | 2.60e-07 | 0.398 | 1.76e-05 |
| REACTOME CYTOSOLIC TRNA AMINOACYLATION | 22 | 1.35e-03 | 0.395 | 1.15e-02 |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 53 | 6.93e-07 | 0.395 | 2.70e-05 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 11 | 2.51e-02 | -0.390 | 1.04e-01 |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 46 | 6.23e-06 | 0.385 | 1.33e-04 |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 56 | 6.29e-07 | 0.385 | 2.68e-05 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 17 | 6.14e-03 | -0.384 | 3.59e-02 |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 60 | 2.98e-07 | 0.383 | 1.76e-05 |
| REACTOME NCAM1 INTERACTIONS | 15 | 1.05e-02 | 0.382 | 5.58e-02 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 56 | 8.53e-07 | 0.381 | 2.85e-05 |
| REACTOME POTASSIUM CHANNELS | 22 | 2.59e-03 | -0.371 | 1.86e-02 |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 45 | 1.74e-05 | 0.371 | 2.80e-04 |
| REACTOME M G1 TRANSITION | 51 | 4.89e-06 | 0.370 | 1.20e-04 |
| REACTOME SIGNALING BY NOTCH2 | 11 | 3.54e-02 | -0.366 | 1.36e-01 |
| REACTOME REGULATION OF APOPTOSIS | 48 | 1.39e-05 | 0.363 | 2.40e-04 |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | 10 | 4.74e-02 | -0.362 | 1.65e-01 |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 53 | 9.18e-06 | 0.353 | 1.72e-04 |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 18 | 1.08e-02 | -0.347 | 5.60e-02 |
| REACTOME COMPLEMENT CASCADE | 11 | 5.12e-02 | 0.340 | 1.75e-01 |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 50 | 4.31e-05 | 0.335 | 6.50e-04 |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 15 | 2.54e-02 | -0.334 | 1.04e-01 |
| REACTOME SYNTHESIS OF DNA | 61 | 6.87e-06 | 0.333 | 1.40e-04 |
| REACTOME GLUCOSE METABOLISM | 43 | 1.74e-04 | 0.331 | 2.32e-03 |
| REACTOME GPCR LIGAND BINDING | 42 | 2.12e-04 | -0.331 | 2.76e-03 |
| REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 20 | 1.08e-02 | -0.330 | 5.60e-02 |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 24 | 5.38e-03 | -0.328 | 3.32e-02 |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 17 | 1.94e-02 | -0.328 | 8.49e-02 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 11 | 6.09e-02 | -0.326 | 1.93e-01 |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 20 | 1.16e-02 | -0.326 | 5.84e-02 |
| REACTOME SIGNALING BY WNT | 56 | 2.60e-05 | 0.325 | 4.06e-04 |
| REACTOME GLUCONEOGENESIS | 18 | 1.78e-02 | 0.323 | 8.24e-02 |
| REACTOME SIGNAL AMPLIFICATION | 15 | 3.25e-02 | -0.319 | 1.27e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pANOVA | s.dist | p.adjustANOVA |
|---|---|---|---|---|
| REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 11 | 4.16e-04 | 0.615000 | 4.14e-03 |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 40 | 2.02e-07 | 0.475000 | 1.76e-05 |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 42 | 1.53e-07 | 0.468000 | 1.76e-05 |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 40 | 3.58e-07 | 0.465000 | 1.76e-05 |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 42 | 3.49e-07 | 0.455000 | 1.76e-05 |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 42 | 3.77e-07 | 0.453000 | 1.76e-05 |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 45 | 2.84e-07 | 0.443000 | 1.76e-05 |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 43 | 8.27e-07 | 0.435000 | 2.85e-05 |
| REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 14 | 4.91e-03 | 0.434000 | 3.15e-02 |
| REACTOME ER PHAGOSOME PATHWAY | 48 | 2.10e-07 | 0.433000 | 1.76e-05 |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 42 | 1.26e-06 | 0.432000 | 3.48e-05 |
| REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 13 | 6.97e-03 | -0.432000 | 3.98e-02 |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 10 | 2.34e-02 | -0.414000 | 9.95e-02 |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 48 | 9.23e-07 | 0.410000 | 2.88e-05 |
| REACTOME SIGNALING BY NOTCH4 | 11 | 1.89e-02 | -0.409000 | 8.34e-02 |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 49 | 9.92e-07 | 0.404000 | 2.90e-05 |
| REACTOME SIGNALING BY NOTCH3 | 11 | 2.08e-02 | -0.403000 | 9.03e-02 |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 43 | 5.35e-06 | 0.401000 | 1.25e-04 |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 56 | 2.60e-07 | 0.398000 | 1.76e-05 |
| REACTOME CYTOSOLIC TRNA AMINOACYLATION | 22 | 1.35e-03 | 0.395000 | 1.15e-02 |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 53 | 6.93e-07 | 0.395000 | 2.70e-05 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 11 | 2.51e-02 | -0.390000 | 1.04e-01 |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 46 | 6.23e-06 | 0.385000 | 1.33e-04 |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 56 | 6.29e-07 | 0.385000 | 2.68e-05 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 17 | 6.14e-03 | -0.384000 | 3.59e-02 |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 60 | 2.98e-07 | 0.383000 | 1.76e-05 |
| REACTOME NCAM1 INTERACTIONS | 15 | 1.05e-02 | 0.382000 | 5.58e-02 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 56 | 8.53e-07 | 0.381000 | 2.85e-05 |
| REACTOME POTASSIUM CHANNELS | 22 | 2.59e-03 | -0.371000 | 1.86e-02 |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 45 | 1.74e-05 | 0.371000 | 2.80e-04 |
| REACTOME M G1 TRANSITION | 51 | 4.89e-06 | 0.370000 | 1.20e-04 |
| REACTOME SIGNALING BY NOTCH2 | 11 | 3.54e-02 | -0.366000 | 1.36e-01 |
| REACTOME REGULATION OF APOPTOSIS | 48 | 1.39e-05 | 0.363000 | 2.40e-04 |
| REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | 10 | 4.74e-02 | -0.362000 | 1.65e-01 |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 53 | 9.18e-06 | 0.353000 | 1.72e-04 |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 18 | 1.08e-02 | -0.347000 | 5.60e-02 |
| REACTOME COMPLEMENT CASCADE | 11 | 5.12e-02 | 0.340000 | 1.75e-01 |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 50 | 4.31e-05 | 0.335000 | 6.50e-04 |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 15 | 2.54e-02 | -0.334000 | 1.04e-01 |
| REACTOME SYNTHESIS OF DNA | 61 | 6.87e-06 | 0.333000 | 1.40e-04 |
| REACTOME GLUCOSE METABOLISM | 43 | 1.74e-04 | 0.331000 | 2.32e-03 |
| REACTOME GPCR LIGAND BINDING | 42 | 2.12e-04 | -0.331000 | 2.76e-03 |
| REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 20 | 1.08e-02 | -0.330000 | 5.60e-02 |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 24 | 5.38e-03 | -0.328000 | 3.32e-02 |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 17 | 1.94e-02 | -0.328000 | 8.49e-02 |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 11 | 6.09e-02 | -0.326000 | 1.93e-01 |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 20 | 1.16e-02 | -0.326000 | 5.84e-02 |
| REACTOME SIGNALING BY WNT | 56 | 2.60e-05 | 0.325000 | 4.06e-04 |
| REACTOME GLUCONEOGENESIS | 18 | 1.78e-02 | 0.323000 | 8.24e-02 |
| REACTOME SIGNAL AMPLIFICATION | 15 | 3.25e-02 | -0.319000 | 1.27e-01 |
| REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 13 | 4.66e-02 | 0.319000 | 1.64e-01 |
| REACTOME DOUBLE STRAND BREAK REPAIR | 12 | 5.89e-02 | 0.315000 | 1.92e-01 |
| REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | 12 | 5.93e-02 | -0.315000 | 1.92e-01 |
| REACTOME GLUCAGON TYPE LIGAND RECEPTORS | 10 | 9.02e-02 | -0.309000 | 2.51e-01 |
| REACTOME NRAGE SIGNALS DEATH THROUGH JNK | 27 | 5.69e-03 | -0.308000 | 3.46e-02 |
| REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | 13 | 5.52e-02 | -0.307000 | 1.85e-01 |
| REACTOME ADP SIGNALLING THROUGH P2RY12 | 10 | 9.61e-02 | -0.304000 | 2.62e-01 |
| REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | 11 | 8.15e-02 | 0.303000 | 2.35e-01 |
| REACTOME HS GAG BIOSYNTHESIS | 15 | 4.28e-02 | -0.302000 | 1.57e-01 |
| REACTOME G ALPHA I SIGNALLING EVENTS | 29 | 5.03e-03 | -0.301000 | 3.18e-02 |
| REACTOME BASE EXCISION REPAIR | 13 | 6.03e-02 | 0.301000 | 1.93e-01 |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 11 | 8.43e-02 | 0.301000 | 2.41e-01 |
| REACTOME TRNA AMINOACYLATION | 39 | 1.30e-03 | 0.298000 | 1.13e-02 |
| REACTOME SIGNAL ATTENUATION | 10 | 1.05e-01 | -0.296000 | 2.71e-01 |
| REACTOME INWARDLY RECTIFYING K CHANNELS | 11 | 8.99e-02 | -0.295000 | 2.51e-01 |
| REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 16 | 4.38e-02 | -0.291000 | 1.59e-01 |
| REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 49 | 4.62e-04 | 0.290000 | 4.41e-03 |
| REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 23 | 1.77e-02 | -0.286000 | 8.24e-02 |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 12 | 8.70e-02 | -0.285000 | 2.47e-01 |
| REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | 21 | 2.41e-02 | -0.285000 | 1.01e-01 |
| REACTOME SIGNALING BY ROBO RECEPTOR | 20 | 2.81e-02 | -0.284000 | 1.13e-01 |
| REACTOME CELL CYCLE CHECKPOINTS | 78 | 1.53e-05 | 0.284000 | 2.56e-04 |
| REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 15 | 5.95e-02 | 0.281000 | 1.92e-01 |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 42 | 1.68e-03 | 0.280000 | 1.33e-02 |
| REACTOME PLATELET AGGREGATION PLUG FORMATION | 17 | 4.56e-02 | -0.280000 | 1.62e-01 |
| REACTOME MTORC1 MEDIATED SIGNALLING | 11 | 1.09e-01 | 0.279000 | 2.76e-01 |
| REACTOME G1 S TRANSITION | 67 | 8.14e-05 | 0.279000 | 1.15e-03 |
| REACTOME GLYCOLYSIS | 19 | 3.62e-02 | 0.278000 | 1.38e-01 |
| REACTOME FRS2 MEDIATED CASCADE | 17 | 4.77e-02 | -0.278000 | 1.65e-01 |
| REACTOME S PHASE | 71 | 7.52e-05 | 0.272000 | 1.10e-03 |
| REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | 16 | 6.31e-02 | -0.268000 | 1.97e-01 |
| REACTOME MHC CLASS II ANTIGEN PRESENTATION | 60 | 3.45e-04 | 0.268000 | 3.81e-03 |
| REACTOME G PROTEIN ACTIVATION | 11 | 1.25e-01 | -0.267000 | 3.06e-01 |
| REACTOME VIRAL MESSENGER RNA SYNTHESIS | 14 | 8.46e-02 | 0.266000 | 2.41e-01 |
| REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | 11 | 1.27e-01 | -0.266000 | 3.07e-01 |
| REACTOME SHC MEDIATED CASCADE | 11 | 1.28e-01 | -0.265000 | 3.08e-01 |
| REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 20 | 4.14e-02 | -0.264000 | 1.55e-01 |
| REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 40 | 4.49e-03 | -0.260000 | 2.97e-02 |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 97 | 1.12e-05 | 0.259000 | 2.02e-04 |
| REACTOME SEMAPHORIN INTERACTIONS | 41 | 4.51e-03 | -0.257000 | 2.97e-02 |
| REACTOME SPRY REGULATION OF FGF SIGNALING | 12 | 1.27e-01 | -0.255000 | 3.07e-01 |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 107 | 5.75e-06 | 0.254000 | 1.28e-04 |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | 19 | 5.75e-02 | 0.252000 | 1.90e-01 |
| REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | 20 | 5.20e-02 | -0.251000 | 1.76e-01 |
| REACTOME SIGNALLING TO ERKS | 28 | 2.22e-02 | -0.250000 | 9.53e-02 |
| REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | 10 | 1.74e-01 | -0.248000 | 3.69e-01 |
| REACTOME COLLAGEN FORMATION | 26 | 2.87e-02 | 0.248000 | 1.15e-01 |
| REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 23 | 4.16e-02 | -0.246000 | 1.55e-01 |
| REACTOME RAP1 SIGNALLING | 12 | 1.42e-01 | -0.245000 | 3.27e-01 |
| REACTOME TRANSLATION | 124 | 2.76e-06 | 0.245000 | 7.19e-05 |
| REACTOME HIV INFECTION | 156 | 1.76e-07 | 0.243000 | 1.76e-05 |
| REACTOME IL RECEPTOR SHC SIGNALING | 15 | 1.04e-01 | 0.243000 | 2.70e-01 |
| REACTOME INTERFERON GAMMA SIGNALING | 24 | 4.04e-02 | 0.242000 | 1.52e-01 |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 11 | 1.66e-01 | -0.241000 | 3.62e-01 |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 32 | 1.83e-02 | -0.241000 | 8.24e-02 |
| REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | 39 | 9.25e-03 | -0.241000 | 5.04e-02 |
| REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | 38 | 1.03e-02 | 0.241000 | 5.55e-02 |
| REACTOME PROLONGED ERK ACTIVATION EVENTS | 16 | 9.82e-02 | -0.239000 | 2.64e-01 |
| REACTOME P38MAPK EVENTS | 10 | 2.02e-01 | -0.233000 | 4.05e-01 |
| REACTOME ELONGATION ARREST AND RECOVERY | 24 | 4.84e-02 | 0.233000 | 1.66e-01 |
| REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | 11 | 1.84e-01 | -0.232000 | 3.78e-01 |
| REACTOME PYRUVATE METABOLISM | 16 | 1.11e-01 | 0.230000 | 2.79e-01 |
| REACTOME SMOOTH MUSCLE CONTRACTION | 18 | 9.13e-02 | -0.230000 | 2.53e-01 |
| REACTOME PHOSPHORYLATION OF THE APC C | 14 | 1.37e-01 | 0.230000 | 3.19e-01 |
| REACTOME PEROXISOMAL LIPID METABOLISM | 16 | 1.12e-01 | 0.230000 | 2.79e-01 |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 38 | 1.51e-02 | 0.228000 | 7.30e-02 |
| REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 12 | 1.72e-01 | 0.228000 | 3.68e-01 |
| REACTOME REGULATION OF IFNG SIGNALING | 10 | 2.22e-01 | 0.223000 | 4.25e-01 |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 86 | 3.60e-04 | 0.223000 | 3.81e-03 |
| REACTOME EXTRACELLULAR MATRIX ORGANIZATION | 31 | 3.17e-02 | 0.223000 | 1.25e-01 |
| REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | 13 | 1.69e-01 | -0.220000 | 3.65e-01 |
| REACTOME REGULATION OF INSULIN SECRETION | 39 | 1.74e-02 | -0.220000 | 8.24e-02 |
| REACTOME METAL ION SLC TRANSPORTERS | 12 | 1.87e-01 | -0.220000 | 3.83e-01 |
| REACTOME DNA REPAIR | 68 | 1.93e-03 | 0.218000 | 1.46e-02 |
| REACTOME NEPHRIN INTERACTIONS | 15 | 1.46e-01 | -0.217000 | 3.32e-01 |
| REACTOME CITRIC ACID CYCLE TCA CYCLE | 19 | 1.03e-01 | 0.216000 | 2.70e-01 |
| REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | 26 | 6.17e-02 | -0.212000 | 1.94e-01 |
| REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | 10 | 2.51e-01 | 0.210000 | 4.55e-01 |
| REACTOME ERKS ARE INACTIVATED | 10 | 2.52e-01 | -0.209000 | 4.55e-01 |
| REACTOME NETRIN1 SIGNALING | 21 | 9.79e-02 | -0.209000 | 2.64e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | 25 | 7.14e-02 | 0.208000 | 2.12e-01 |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 50 | 1.14e-02 | 0.207000 | 5.78e-02 |
| REACTOME GPVI MEDIATED ACTIVATION CASCADE | 17 | 1.43e-01 | 0.206000 | 3.27e-01 |
| REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | 16 | 1.55e-01 | -0.205000 | 3.46e-01 |
| REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | 21 | 1.06e-01 | 0.204000 | 2.72e-01 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 13 | 2.05e-01 | -0.203000 | 4.05e-01 |
| REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | 18 | 1.37e-01 | -0.203000 | 3.19e-01 |
| REACTOME DEADENYLATION OF MRNA | 16 | 1.62e-01 | 0.202000 | 3.58e-01 |
| REACTOME MITOTIC G1 G1 S PHASES | 83 | 1.55e-03 | 0.201000 | 1.25e-02 |
| REACTOME KERATAN SULFATE BIOSYNTHESIS | 11 | 2.52e-01 | 0.200000 | 4.55e-01 |
| REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | 15 | 1.83e-01 | 0.199000 | 3.78e-01 |
| REACTOME MRNA SPLICING | 100 | 6.37e-04 | 0.198000 | 5.84e-03 |
| REACTOME PLATELET SENSITIZATION BY LDL | 11 | 2.56e-01 | -0.198000 | 4.57e-01 |
| REACTOME GABA RECEPTOR ACTIVATION | 16 | 1.71e-01 | -0.198000 | 3.67e-01 |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 81 | 2.19e-03 | 0.197000 | 1.60e-02 |
| REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 52 | 1.40e-02 | -0.197000 | 6.91e-02 |
| REACTOME G ALPHA S SIGNALLING EVENTS | 29 | 6.82e-02 | -0.196000 | 2.06e-01 |
| REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | 32 | 5.57e-02 | -0.196000 | 1.85e-01 |
| REACTOME PLATELET HOMEOSTASIS | 33 | 5.25e-02 | -0.195000 | 1.77e-01 |
| REACTOME RNA POL III TRANSCRIPTION | 31 | 6.10e-02 | 0.195000 | 1.93e-01 |
| REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | 28 | 7.63e-02 | 0.194000 | 2.23e-01 |
| REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | 19 | 1.46e-01 | 0.193000 | 3.32e-01 |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 55 | 1.37e-02 | -0.192000 | 6.82e-02 |
| REACTOME MRNA CAPPING | 28 | 7.85e-02 | 0.192000 | 2.28e-01 |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 15 | 2.03e-01 | -0.190000 | 4.05e-01 |
| REACTOME MRNA PROCESSING | 139 | 1.27e-04 | 0.189000 | 1.75e-03 |
| REACTOME PEPTIDE CHAIN ELONGATION | 67 | 7.63e-03 | 0.189000 | 4.30e-02 |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 190 | 8.20e-06 | 0.189000 | 1.60e-04 |
| REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | 13 | 2.40e-01 | 0.188000 | 4.47e-01 |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 72 | 5.95e-03 | 0.188000 | 3.55e-02 |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 126 | 3.30e-04 | 0.186000 | 3.81e-03 |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 89 | 2.67e-03 | 0.185000 | 1.89e-02 |
| REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 12 | 2.68e-01 | -0.185000 | 4.74e-01 |
| REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | 21 | 1.47e-01 | -0.183000 | 3.33e-01 |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 98 | 1.83e-03 | -0.183000 | 1.43e-02 |
| REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | 56 | 1.85e-02 | 0.182000 | 8.24e-02 |
| REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 10 | 3.20e-01 | -0.182000 | 5.32e-01 |
| REACTOME MICRORNA MIRNA BIOGENESIS | 18 | 1.83e-01 | 0.182000 | 3.78e-01 |
| REACTOME ARMS MEDIATED ACTIVATION | 14 | 2.41e-01 | -0.181000 | 4.47e-01 |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 16 | 2.11e-01 | 0.181000 | 4.13e-01 |
| REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | 20 | 1.63e-01 | 0.180000 | 3.58e-01 |
| REACTOME ERK MAPK TARGETS | 18 | 1.87e-01 | -0.180000 | 3.83e-01 |
| REACTOME SIGNALLING TO RAS | 20 | 1.65e-01 | -0.179000 | 3.61e-01 |
| REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 43 | 4.21e-02 | 0.179000 | 1.55e-01 |
| REACTOME ACTIVATION OF BH3 ONLY PROTEINS | 11 | 3.07e-01 | -0.178000 | 5.23e-01 |
| REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 17 | 2.05e-01 | -0.178000 | 4.05e-01 |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 83 | 5.29e-03 | 0.178000 | 3.30e-02 |
| REACTOME INFLUENZA LIFE CYCLE | 114 | 1.17e-03 | 0.177000 | 1.03e-02 |
| REACTOME MYOGENESIS | 21 | 1.62e-01 | -0.177000 | 3.58e-01 |
| REACTOME HIV LIFE CYCLE | 94 | 3.25e-03 | 0.176000 | 2.24e-02 |
| REACTOME GABA B RECEPTOR ACTIVATION | 15 | 2.42e-01 | -0.175000 | 4.47e-01 |
| REACTOME GPCR DOWNSTREAM SIGNALING | 107 | 2.01e-03 | -0.173000 | 1.50e-02 |
| REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 15 | 2.55e-01 | 0.170000 | 4.57e-01 |
| REACTOME MEIOSIS | 24 | 1.50e-01 | 0.170000 | 3.38e-01 |
| REACTOME TRANSCRIPTION | 127 | 1.12e-03 | 0.168000 | 1.01e-02 |
| REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | 27 | 1.31e-01 | 0.168000 | 3.13e-01 |
| REACTOME NUCLEOTIDE EXCISION REPAIR | 40 | 6.77e-02 | 0.167000 | 2.06e-01 |
| REACTOME FATTY ACYL COA BIOSYNTHESIS | 12 | 3.17e-01 | 0.167000 | 5.31e-01 |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 54 | 3.44e-02 | -0.167000 | 1.33e-01 |
| REACTOME MITOTIC M M G1 PHASES | 96 | 4.90e-03 | 0.167000 | 3.15e-02 |
| REACTOME BASIGIN INTERACTIONS | 14 | 2.81e-01 | 0.167000 | 4.92e-01 |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 165 | 2.40e-04 | 0.167000 | 2.88e-03 |
| REACTOME RNA POL II TRANSCRIPTION | 86 | 7.99e-03 | 0.166000 | 4.45e-02 |
| REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | 10 | 3.64e-01 | -0.166000 | 5.66e-01 |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 12 | 3.21e-01 | -0.166000 | 5.32e-01 |
| REACTOME SIGNALING BY RHO GTPASES | 63 | 2.36e-02 | -0.165000 | 9.95e-02 |
| REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 21 | 1.95e-01 | -0.164000 | 3.95e-01 |
| REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | 17 | 2.46e-01 | -0.163000 | 4.52e-01 |
| REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | 13 | 3.11e-01 | -0.162000 | 5.28e-01 |
| REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | 18 | 2.36e-01 | -0.161000 | 4.44e-01 |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 97 | 6.21e-03 | 0.161000 | 3.59e-02 |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 13 | 3.16e-01 | -0.161000 | 5.31e-01 |
| REACTOME STRIATED MUSCLE CONTRACTION | 22 | 1.95e-01 | 0.160000 | 3.95e-01 |
| REACTOME ACTIVATED TLR4 SIGNALLING | 62 | 3.04e-02 | -0.159000 | 1.21e-01 |
| REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX | 35 | 1.04e-01 | 0.159000 | 2.70e-01 |
| REACTOME DNA REPLICATION | 108 | 4.46e-03 | 0.159000 | 2.97e-02 |
| REACTOME TRANSCRIPTION COUPLED NER TC NER | 36 | 1.02e-01 | 0.158000 | 2.70e-01 |
| REACTOME REGULATION OF KIT SIGNALING | 10 | 3.90e-01 | -0.157000 | 5.87e-01 |
| REACTOME FORMATION OF INCISION COMPLEX IN GG NER | 18 | 2.50e-01 | 0.157000 | 4.55e-01 |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 25 | 1.76e-01 | -0.157000 | 3.71e-01 |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 13 | 3.30e-01 | -0.156000 | 5.36e-01 |
| REACTOME GLOBAL GENOMIC NER GG NER | 25 | 1.78e-01 | 0.156000 | 3.73e-01 |
| REACTOME NEURONAL SYSTEM | 90 | 1.10e-02 | -0.156000 | 5.63e-02 |
| REACTOME REGULATORY RNA PATHWAYS | 21 | 2.18e-01 | 0.155000 | 4.23e-01 |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 80 | 1.67e-02 | -0.155000 | 8.00e-02 |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 107 | 6.00e-03 | 0.154000 | 3.55e-02 |
| REACTOME APOPTOSIS | 97 | 8.89e-03 | 0.154000 | 4.89e-02 |
| REACTOME SIGNALING BY NODAL | 11 | 3.77e-01 | -0.154000 | 5.77e-01 |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 57 | 4.58e-02 | -0.153000 | 1.62e-01 |
| REACTOME METABOLISM OF MRNA | 178 | 4.56e-04 | 0.153000 | 4.41e-03 |
| REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | 14 | 3.22e-01 | -0.153000 | 5.32e-01 |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 86 | 1.44e-02 | 0.153000 | 7.04e-02 |
| REACTOME SHC RELATED EVENTS | 14 | 3.23e-01 | -0.153000 | 5.32e-01 |
| REACTOME SIGNALING BY GPCR | 149 | 1.39e-03 | -0.152000 | 1.16e-02 |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 58 | 4.58e-02 | -0.152000 | 1.62e-01 |
| REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | 38 | 1.06e-01 | 0.152000 | 2.72e-01 |
| REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | 28 | 1.68e-01 | 0.151000 | 3.63e-01 |
| REACTOME CELL CYCLE MITOTIC | 190 | 3.66e-04 | 0.151000 | 3.81e-03 |
| REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | 24 | 2.03e-01 | 0.150000 | 4.05e-01 |
| REACTOME SYNTHESIS OF PA | 10 | 4.11e-01 | -0.150000 | 5.99e-01 |
| REACTOME MAP KINASE ACTIVATION IN TLR CASCADE | 42 | 9.27e-02 | -0.150000 | 2.55e-01 |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 85 | 1.82e-02 | 0.149000 | 8.24e-02 |
| REACTOME CELL CELL COMMUNICATION | 53 | 6.35e-02 | -0.148000 | 1.97e-01 |
| REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | 15 | 3.30e-01 | 0.145000 | 5.36e-01 |
| REACTOME AXON GUIDANCE | 141 | 3.01e-03 | -0.145000 | 2.11e-02 |
| REACTOME G0 AND EARLY G1 | 12 | 3.91e-01 | -0.143000 | 5.87e-01 |
| REACTOME HEMOSTASIS | 218 | 3.47e-04 | -0.142000 | 3.81e-03 |
| REACTOME METABOLISM OF RNA | 217 | 3.62e-04 | 0.141000 | 3.81e-03 |
| REACTOME G2 M CHECKPOINTS | 17 | 3.14e-01 | 0.141000 | 5.31e-01 |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 54 | 7.45e-02 | -0.141000 | 2.19e-01 |
| REACTOME ENOS ACTIVATION AND REGULATION | 12 | 4.01e-01 | -0.140000 | 5.90e-01 |
| REACTOME PKB MEDIATED EVENTS | 27 | 2.09e-01 | 0.140000 | 4.11e-01 |
| REACTOME RNA POL I TRANSCRIPTION TERMINATION | 19 | 2.92e-01 | 0.140000 | 5.06e-01 |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 176 | 1.52e-03 | -0.139000 | 1.25e-02 |
| REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 47 | 1.01e-01 | -0.139000 | 2.70e-01 |
| REACTOME TRAFFICKING OF AMPA RECEPTORS | 16 | 3.40e-01 | 0.138000 | 5.47e-01 |
| REACTOME CELL CYCLE | 216 | 5.65e-04 | 0.137000 | 5.29e-03 |
| REACTOME PIP3 ACTIVATES AKT SIGNALING | 25 | 2.37e-01 | -0.137000 | 4.44e-01 |
| REACTOME SIGNALLING TO P38 VIA RIT AND RIN | 11 | 4.33e-01 | -0.137000 | 6.22e-01 |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 52 | 9.01e-02 | -0.136000 | 2.51e-01 |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 28 | 2.13e-01 | -0.136000 | 4.16e-01 |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | 16 | 3.47e-01 | 0.136000 | 5.55e-01 |
| REACTOME METABOLISM OF PORPHYRINS | 12 | 4.16e-01 | -0.136000 | 6.03e-01 |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 22 | 2.73e-01 | -0.135000 | 4.80e-01 |
| REACTOME DEVELOPMENTAL BIOLOGY | 237 | 4.14e-04 | -0.134000 | 4.14e-03 |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 23 | 2.68e-01 | -0.133000 | 4.74e-01 |
| REACTOME NOD1 2 SIGNALING PATHWAY | 18 | 3.28e-01 | -0.133000 | 5.36e-01 |
| REACTOME MITOTIC G2 G2 M PHASES | 49 | 1.07e-01 | 0.133000 | 2.73e-01 |
| REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 19 | 3.18e-01 | -0.133000 | 5.31e-01 |
| REACTOME EFFECTS OF PIP2 HYDROLYSIS | 14 | 3.92e-01 | -0.132000 | 5.87e-01 |
| REACTOME G ALPHA1213 SIGNALLING EVENTS | 43 | 1.36e-01 | -0.131000 | 3.19e-01 |
| REACTOME MITOCHONDRIAL PROTEIN IMPORT | 42 | 1.41e-01 | 0.131000 | 3.27e-01 |
| REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | 17 | 3.51e-01 | 0.131000 | 5.56e-01 |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 66 | 6.78e-02 | -0.130000 | 2.06e-01 |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 17 | 3.54e-01 | -0.130000 | 5.56e-01 |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 111 | 1.85e-02 | -0.130000 | 8.24e-02 |
| REACTOME SIGNALING BY NOTCH1 | 51 | 1.11e-01 | -0.129000 | 2.78e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | 22 | 2.94e-01 | 0.129000 | 5.06e-01 |
| REACTOME RNA POL I TRANSCRIPTION INITIATION | 23 | 2.86e-01 | 0.129000 | 4.99e-01 |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 47 | 1.27e-01 | -0.129000 | 3.07e-01 |
| REACTOME RNA POL I TRANSCRIPTION | 26 | 2.58e-01 | 0.128000 | 4.59e-01 |
| REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | 13 | 4.24e-01 | -0.128000 | 6.13e-01 |
| REACTOME RNA POL III CHAIN ELONGATION | 16 | 3.76e-01 | 0.128000 | 5.77e-01 |
| REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | 12 | 4.48e-01 | -0.126000 | 6.38e-01 |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 59 | 9.38e-02 | -0.126000 | 2.57e-01 |
| REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | 16 | 3.82e-01 | -0.126000 | 5.81e-01 |
| REACTOME DOWNSTREAM TCR SIGNALING | 20 | 3.30e-01 | 0.126000 | 5.36e-01 |
| REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | 48 | 1.34e-01 | 0.125000 | 3.18e-01 |
| REACTOME CTLA4 INHIBITORY SIGNALING | 16 | 3.93e-01 | -0.123000 | 5.87e-01 |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 12 | 4.60e-01 | 0.123000 | 6.49e-01 |
| REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | 29 | 2.56e-01 | 0.122000 | 4.57e-01 |
| REACTOME SIGNALING BY NOTCH | 75 | 6.90e-02 | -0.122000 | 2.06e-01 |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 62 | 1.01e-01 | -0.121000 | 2.70e-01 |
| REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | 13 | 4.55e-01 | 0.120000 | 6.45e-01 |
| REACTOME SULFUR AMINO ACID METABOLISM | 17 | 3.94e-01 | 0.119000 | 5.87e-01 |
| REACTOME PI 3K CASCADE | 35 | 2.23e-01 | -0.119000 | 4.25e-01 |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 44 | 1.74e-01 | -0.119000 | 3.69e-01 |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 336 | 2.21e-04 | 0.118000 | 2.80e-03 |
| REACTOME INTERFERON SIGNALING | 81 | 6.68e-02 | 0.118000 | 2.06e-01 |
| REACTOME SEMA4D IN SEMAPHORIN SIGNALING | 21 | 3.53e-01 | -0.117000 | 5.56e-01 |
| REACTOME TRIGLYCERIDE BIOSYNTHESIS | 22 | 3.44e-01 | 0.117000 | 5.52e-01 |
| REACTOME L1CAM INTERACTIONS | 51 | 1.51e-01 | -0.116000 | 3.38e-01 |
| REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 19 | 3.82e-01 | -0.116000 | 5.81e-01 |
| REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | 18 | 4.02e-01 | -0.114000 | 5.90e-01 |
| REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | 10 | 5.34e-01 | 0.113000 | 6.91e-01 |
| REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | 22 | 3.59e-01 | 0.113000 | 5.61e-01 |
| REACTOME SOS MEDIATED SIGNALLING | 13 | 4.90e-01 | -0.111000 | 6.75e-01 |
| REACTOME METABOLISM OF POLYAMINES | 13 | 4.95e-01 | 0.109000 | 6.76e-01 |
| REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | 10 | 5.58e-01 | -0.107000 | 7.08e-01 |
| REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | 22 | 3.86e-01 | -0.107000 | 5.84e-01 |
| REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | 14 | 4.93e-01 | -0.106000 | 6.76e-01 |
| REACTOME CTNNB1 PHOSPHORYLATION CASCADE | 14 | 4.95e-01 | -0.105000 | 6.76e-01 |
| REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | 13 | 5.11e-01 | -0.105000 | 6.86e-01 |
| REACTOME METABOLISM OF PROTEINS | 301 | 1.88e-03 | 0.105000 | 1.44e-02 |
| REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 11 | 5.46e-01 | 0.105000 | 7.02e-01 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 73 | 1.22e-01 | 0.105000 | 3.02e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | 14 | 5.00e-01 | 0.104000 | 6.80e-01 |
| REACTOME SIGNALLING BY NGF | 155 | 2.77e-02 | -0.103000 | 1.13e-01 |
| REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 71 | 1.36e-01 | -0.103000 | 3.19e-01 |
| REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 52 | 2.05e-01 | 0.102000 | 4.05e-01 |
| REACTOME CELL JUNCTION ORGANIZATION | 29 | 3.53e-01 | -0.099700 | 5.56e-01 |
| REACTOME SIGNAL TRANSDUCTION BY L1 | 28 | 3.66e-01 | -0.098800 | 5.67e-01 |
| REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | 10 | 5.96e-01 | -0.096900 | 7.26e-01 |
| REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | 17 | 4.90e-01 | 0.096900 | 6.75e-01 |
| REACTOME MEIOTIC SYNAPSIS | 15 | 5.17e-01 | 0.096600 | 6.86e-01 |
| REACTOME IMMUNE SYSTEM | 517 | 2.32e-04 | 0.096200 | 2.86e-03 |
| REACTOME DESTABILIZATION OF MRNA BY BRF1 | 16 | 5.14e-01 | -0.094400 | 6.86e-01 |
| REACTOME MRNA 3 END PROCESSING | 31 | 3.69e-01 | 0.093300 | 5.69e-01 |
| REACTOME METABOLISM OF CARBOHYDRATES | 129 | 6.88e-02 | 0.093200 | 2.06e-01 |
| REACTOME SIGNALING BY FGFR | 70 | 1.81e-01 | -0.092700 | 3.78e-01 |
| REACTOME SHC MEDIATED SIGNALLING | 13 | 5.64e-01 | -0.092400 | 7.11e-01 |
| REACTOME LYSOSOME VESICLE BIOGENESIS | 17 | 5.19e-01 | 0.090400 | 6.86e-01 |
| REACTOME INTERFERON ALPHA BETA SIGNALING | 17 | 5.24e-01 | -0.089300 | 6.88e-01 |
| REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | 22 | 4.71e-01 | 0.088800 | 6.58e-01 |
| REACTOME IL 2 SIGNALING | 25 | 4.46e-01 | 0.088200 | 6.36e-01 |
| REACTOME OPIOID SIGNALLING | 41 | 3.31e-01 | -0.087800 | 5.36e-01 |
| REACTOME SPHINGOLIPID METABOLISM | 36 | 3.63e-01 | 0.087800 | 5.66e-01 |
| REACTOME PURINE SALVAGE | 10 | 6.32e-01 | -0.087600 | 7.50e-01 |
| REACTOME PI3K EVENTS IN ERBB4 SIGNALING | 28 | 4.26e-01 | -0.087000 | 6.13e-01 |
| REACTOME METABOLISM OF NUCLEOTIDES | 48 | 3.02e-01 | 0.086200 | 5.18e-01 |
| REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | 24 | 4.66e-01 | 0.086100 | 6.55e-01 |
| REACTOME SIGNALING BY HIPPO | 15 | 5.69e-01 | 0.085000 | 7.11e-01 |
| REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | 16 | 5.59e-01 | -0.084400 | 7.08e-01 |
| REACTOME CIRCADIAN CLOCK | 43 | 3.40e-01 | -0.084200 | 5.47e-01 |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 17 | 5.52e-01 | -0.083300 | 7.06e-01 |
| REACTOME RECYCLING PATHWAY OF L1 | 19 | 5.36e-01 | 0.082000 | 6.91e-01 |
| REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | 44 | 3.49e-01 | 0.081700 | 5.56e-01 |
| REACTOME DNA STRAND ELONGATION | 14 | 5.97e-01 | 0.081600 | 7.26e-01 |
| REACTOME TIE2 SIGNALING | 13 | 6.11e-01 | 0.081500 | 7.37e-01 |
| REACTOME IL 3 5 AND GM CSF SIGNALING | 25 | 4.81e-01 | 0.081400 | 6.71e-01 |
| REACTOME DARPP 32 EVENTS | 18 | 5.55e-01 | -0.080400 | 7.08e-01 |
| REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | 37 | 4.02e-01 | -0.079700 | 5.90e-01 |
| REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 16 | 5.82e-01 | -0.079600 | 7.16e-01 |
| REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | 17 | 5.72e-01 | 0.079300 | 7.11e-01 |
| REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | 14 | 6.08e-01 | 0.079100 | 7.36e-01 |
| REACTOME TELOMERE MAINTENANCE | 19 | 5.52e-01 | 0.078900 | 7.06e-01 |
| REACTOME MRNA SPLICING MINOR PATHWAY | 39 | 3.95e-01 | 0.078700 | 5.88e-01 |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 38 | 4.02e-01 | -0.078700 | 5.90e-01 |
| REACTOME G ALPHA Z SIGNALLING EVENTS | 22 | 5.25e-01 | -0.078300 | 6.88e-01 |
| REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 61 | 2.93e-01 | -0.077900 | 5.06e-01 |
| REACTOME RESPIRATORY ELECTRON TRANSPORT | 59 | 3.04e-01 | 0.077500 | 5.20e-01 |
| REACTOME SIGNALING BY FGFR IN DISEASE | 83 | 2.29e-01 | -0.076700 | 4.35e-01 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 136 | 1.24e-01 | -0.076700 | 3.06e-01 |
| REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | 22 | 5.34e-01 | -0.076600 | 6.91e-01 |
| REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 25 | 5.08e-01 | -0.076600 | 6.85e-01 |
| REACTOME KERATAN SULFATE KERATIN METABOLISM | 14 | 6.29e-01 | 0.074600 | 7.49e-01 |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | 15 | 6.20e-01 | 0.073900 | 7.41e-01 |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 37 | 4.41e-01 | -0.073300 | 6.31e-01 |
| REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | 10 | 6.92e-01 | 0.072300 | 8.00e-01 |
| REACTOME SIGNALING BY FGFR1 MUTANTS | 21 | 5.68e-01 | -0.072000 | 7.11e-01 |
| REACTOME TOLL RECEPTOR CASCADES | 75 | 2.88e-01 | -0.071100 | 5.01e-01 |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 101 | 2.19e-01 | -0.071000 | 4.24e-01 |
| REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION | 98 | 2.30e-01 | -0.070400 | 4.35e-01 |
| REACTOME MEMBRANE TRAFFICKING | 93 | 2.48e-01 | 0.069600 | 4.54e-01 |
| REACTOME SIGNALING BY FGFR MUTANTS | 28 | 5.25e-01 | -0.069500 | 6.88e-01 |
| REACTOME PURINE METABOLISM | 27 | 5.34e-01 | 0.069300 | 6.91e-01 |
| REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 21 | 5.86e-01 | -0.068700 | 7.18e-01 |
| REACTOME HS GAG DEGRADATION | 11 | 6.94e-01 | 0.068600 | 8.00e-01 |
| REACTOME RNA POL III TRANSCRIPTION TERMINATION | 18 | 6.18e-01 | 0.068000 | 7.39e-01 |
| REACTOME PI3K AKT ACTIVATION | 31 | 5.17e-01 | -0.067300 | 6.86e-01 |
| REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 23 | 5.79e-01 | 0.066900 | 7.15e-01 |
| REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | 29 | 5.34e-01 | -0.066800 | 6.91e-01 |
| REACTOME CHOLESTEROL BIOSYNTHESIS | 13 | 6.78e-01 | -0.066500 | 7.89e-01 |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 53 | 4.03e-01 | -0.066500 | 5.90e-01 |
| REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | 42 | 4.70e-01 | -0.064600 | 6.58e-01 |
| REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | 11 | 7.12e-01 | 0.064300 | 8.14e-01 |
| REACTOME SIGNALING BY ERBB2 | 68 | 3.69e-01 | -0.063100 | 5.69e-01 |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 127 | 2.22e-01 | -0.063000 | 4.25e-01 |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | 11 | 7.18e-01 | 0.062800 | 8.18e-01 |
| REACTOME INSULIN RECEPTOR RECYCLING | 15 | 6.78e-01 | 0.062000 | 7.89e-01 |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 22 | 6.16e-01 | -0.061800 | 7.39e-01 |
| REACTOME GLUTATHIONE CONJUGATION | 12 | 7.14e-01 | -0.061200 | 8.14e-01 |
| REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | 17 | 6.69e-01 | -0.060000 | 7.82e-01 |
| REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | 17 | 6.69e-01 | -0.060000 | 7.82e-01 |
| REACTOME UNFOLDED PROTEIN RESPONSE | 63 | 4.13e-01 | -0.059800 | 6.00e-01 |
| REACTOME METABOLISM OF NON CODING RNA | 42 | 5.04e-01 | 0.059700 | 6.82e-01 |
| REACTOME PI3K CASCADE | 46 | 4.91e-01 | 0.058800 | 6.75e-01 |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | 33 | 5.60e-01 | 0.058700 | 7.08e-01 |
| REACTOME CALNEXIN CALRETICULIN CYCLE | 11 | 7.37e-01 | 0.058500 | 8.37e-01 |
| REACTOME DEADENYLATION DEPENDENT MRNA DECAY | 39 | 5.32e-01 | 0.058000 | 6.91e-01 |
| REACTOME SIGNALING BY SCF KIT | 57 | 4.57e-01 | -0.057000 | 6.47e-01 |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 148 | 2.34e-01 | 0.057000 | 4.41e-01 |
| REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 33 | 5.72e-01 | -0.056900 | 7.11e-01 |
| REACTOME PLC BETA MEDIATED EVENTS | 20 | 6.61e-01 | -0.056600 | 7.79e-01 |
| REACTOME MITOTIC PROMETAPHASE | 44 | 5.16e-01 | -0.056600 | 6.86e-01 |
| REACTOME CD28 CO STIMULATION | 22 | 6.47e-01 | 0.056400 | 7.67e-01 |
| REACTOME PRE NOTCH EXPRESSION AND PROCESSING | 31 | 5.99e-01 | -0.054700 | 7.26e-01 |
| REACTOME PI METABOLISM | 37 | 5.68e-01 | 0.054300 | 7.11e-01 |
| REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | 50 | 5.14e-01 | 0.053500 | 6.86e-01 |
| REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | 36 | 5.84e-01 | 0.052800 | 7.18e-01 |
| REACTOME LIPOPROTEIN METABOLISM | 11 | 7.64e-01 | 0.052200 | 8.52e-01 |
| REACTOME PHASE II CONJUGATION | 24 | 6.65e-01 | 0.051000 | 7.82e-01 |
| REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | 10 | 7.83e-01 | -0.050400 | 8.64e-01 |
| REACTOME INSULIN SYNTHESIS AND PROCESSING | 13 | 7.58e-01 | 0.049300 | 8.47e-01 |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 62 | 5.03e-01 | -0.049300 | 6.82e-01 |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 14 | 7.51e-01 | -0.049000 | 8.45e-01 |
| REACTOME SIGNALING BY ERBB4 | 67 | 4.89e-01 | -0.049000 | 6.75e-01 |
| REACTOME PROTEIN FOLDING | 40 | 6.13e-01 | 0.046300 | 7.37e-01 |
| REACTOME EGFR DOWNREGULATION | 23 | 7.11e-01 | 0.044700 | 8.14e-01 |
| REACTOME ION TRANSPORT BY P TYPE ATPASES | 17 | 7.50e-01 | 0.044700 | 8.45e-01 |
| REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | 17 | 7.59e-01 | 0.043100 | 8.47e-01 |
| REACTOME DAG AND IP3 SIGNALING | 16 | 7.69e-01 | -0.042500 | 8.54e-01 |
| REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | 16 | 7.81e-01 | -0.040200 | 8.64e-01 |
| REACTOME IRON UPTAKE AND TRANSPORT | 23 | 7.43e-01 | -0.039600 | 8.42e-01 |
| REACTOME BOTULINUM NEUROTOXICITY | 10 | 8.30e-01 | -0.039300 | 8.97e-01 |
| REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | 10 | 8.30e-01 | -0.039300 | 8.97e-01 |
| REACTOME SIGNALING BY INSULIN RECEPTOR | 74 | 5.72e-01 | 0.038000 | 7.11e-01 |
| REACTOME SIGNALING BY BMP | 17 | 7.87e-01 | -0.037800 | 8.67e-01 |
| REACTOME CHROMOSOME MAINTENANCE | 36 | 7.08e-01 | 0.036100 | 8.14e-01 |
| REACTOME DIABETES PATHWAYS | 90 | 5.79e-01 | -0.033900 | 7.15e-01 |
| REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA | 18 | 8.08e-01 | -0.033100 | 8.85e-01 |
| REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 21 | 8.06e-01 | -0.031000 | 8.85e-01 |
| REACTOME PROCESSING OF INTRONLESS PRE MRNAS | 13 | 8.49e-01 | 0.030500 | 9.09e-01 |
| REACTOME PRE NOTCH PROCESSING IN GOLGI | 14 | 8.47e-01 | -0.029800 | 9.09e-01 |
| REACTOME PHOSPHOLIPID METABOLISM | 114 | 5.92e-01 | 0.029200 | 7.23e-01 |
| REACTOME PI3K EVENTS IN ERBB2 SIGNALING | 32 | 7.76e-01 | -0.029100 | 8.60e-01 |
| REACTOME SIGNALING BY ILS | 66 | 6.84e-01 | -0.029100 | 7.94e-01 |
| REACTOME LAGGING STRAND SYNTHESIS | 10 | 8.78e-01 | 0.028000 | 9.32e-01 |
| REACTOME SIGNALING BY PDGF | 86 | 6.54e-01 | -0.028000 | 7.73e-01 |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 44 | 7.53e-01 | -0.027500 | 8.45e-01 |
| REACTOME G1 PHASE | 25 | 8.16e-01 | -0.026800 | 8.89e-01 |
| REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | 11 | 8.81e-01 | 0.026000 | 9.33e-01 |
| REACTOME IL1 SIGNALING | 26 | 8.19e-01 | -0.025900 | 8.89e-01 |
| REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | 18 | 8.53e-01 | -0.025300 | 9.11e-01 |
| REACTOME GLUCOSE TRANSPORT | 30 | 8.17e-01 | -0.024400 | 8.89e-01 |
| REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 17 | 8.62e-01 | 0.024300 | 9.19e-01 |
| REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | 34 | 8.10e-01 | 0.023900 | 8.85e-01 |
| REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | 16 | 8.74e-01 | -0.023000 | 9.29e-01 |
| REACTOME GROWTH HORMONE RECEPTOR SIGNALING | 17 | 8.86e-01 | -0.020200 | 9.35e-01 |
| REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | 13 | 9.04e-01 | -0.019400 | 9.52e-01 |
| REACTOME P75NTR SIGNALS VIA NFKB | 10 | 9.27e-01 | 0.016800 | 9.64e-01 |
| REACTOME INNATE IMMUNE SYSTEM | 122 | 7.51e-01 | -0.016700 | 8.45e-01 |
| REACTOME O LINKED GLYCOSYLATION OF MUCINS | 10 | 9.29e-01 | 0.016200 | 9.64e-01 |
| REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 60 | 8.35e-01 | 0.015600 | 9.00e-01 |
| REACTOME ACTIVATION OF GENES BY ATF4 | 19 | 9.08e-01 | -0.015300 | 9.55e-01 |
| REACTOME ASPARAGINE N LINKED GLYCOSYLATION | 62 | 8.43e-01 | 0.014500 | 9.07e-01 |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 280 | 6.91e-01 | -0.013900 | 8.00e-01 |
| REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | 18 | 9.23e-01 | 0.013200 | 9.64e-01 |
| REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 17 | 9.27e-01 | -0.012800 | 9.64e-01 |
| REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | 12 | 9.39e-01 | -0.012700 | 9.68e-01 |
| REACTOME ION CHANNEL TRANSPORT | 18 | 9.30e-01 | 0.011900 | 9.64e-01 |
| REACTOME TCR SIGNALING | 27 | 9.16e-01 | 0.011700 | 9.61e-01 |
| REACTOME EXTENSION OF TELOMERES | 15 | 9.38e-01 | 0.011600 | 9.68e-01 |
| REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | 14 | 9.49e-01 | 0.009790 | 9.72e-01 |
| REACTOME APOPTOTIC EXECUTION PHASE | 27 | 9.31e-01 | -0.009640 | 9.64e-01 |
| REACTOME GLYCOSPHINGOLIPID METABOLISM | 21 | 9.47e-01 | 0.008360 | 9.72e-01 |
| REACTOME PERK REGULATED GENE EXPRESSION | 21 | 9.48e-01 | 0.008290 | 9.72e-01 |
| REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | 20 | 9.59e-01 | -0.006580 | 9.76e-01 |
| REACTOME REGULATION OF SIGNALING BY CBL | 14 | 9.70e-01 | 0.005720 | 9.81e-01 |
| REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | 17 | 9.69e-01 | -0.005470 | 9.81e-01 |
| REACTOME BIOLOGICAL OXIDATIONS | 41 | 9.59e-01 | -0.004700 | 9.76e-01 |
| REACTOME GAB1 SIGNALOSOME | 31 | 9.65e-01 | -0.004530 | 9.80e-01 |
| REACTOME SIGNALING BY EGFR IN CANCER | 82 | 9.52e-01 | -0.003880 | 9.73e-01 |
| REACTOME PYRIMIDINE METABOLISM | 10 | 9.83e-01 | 0.003800 | 9.88e-01 |
| REACTOME SHC1 EVENTS IN EGFR SIGNALING | 14 | 9.84e-01 | -0.003060 | 9.88e-01 |
| REACTOME CA DEPENDENT EVENTS | 14 | 9.87e-01 | 0.002590 | 9.89e-01 |
| REACTOME MUSCLE CONTRACTION | 36 | 9.79e-01 | -0.002500 | 9.88e-01 |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 21 | 9.94e-01 | 0.000951 | 9.94e-01 |
Detailed Gene set reports
REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
| 1 | |
|---|---|
| set | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS |
| setSize | 11 |
| pANOVA | 0.000416 |
| s.dist | 0.615 |
| p.adjustANOVA | 0.00414 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Phka1 | 4400 |
| Agl | 4381 |
| Phkb | 4377 |
| Phka2 | 4305 |
| Pygm | 4193 |
| Phkg1 | 3814 |
| Phkg2 | 3164 |
| Pgm1 | 2888 |
| Gyg | 2567 |
| Calm1 | -190 |
| Pygb | -2481 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Phka1 | 4400 |
| Agl | 4381 |
| Phkb | 4377 |
| Phka2 | 4305 |
| Pygm | 4193 |
| Phkg1 | 3814 |
| Phkg2 | 3164 |
| Pgm1 | 2888 |
| Gyg | 2567 |
| Calm1 | -190 |
| Pygb | -2481 |
REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES
| 20 | |
|---|---|
| set | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES |
| setSize | 40 |
| pANOVA | 2.02e-07 |
| s.dist | 0.475 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Mrc1 | 4525 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Mrc1 | 4525 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Psma2 | -1441 |
| Psme1 | -2898 |
| Mrc2 | -4223 |
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
| 421 | |
|---|---|
| set | REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 |
| setSize | 42 |
| pANOVA | 1.53e-07 |
| s.dist | 0.468 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Btrc | 3826 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Btrc | 3826 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cul1 | 1053 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
| 124 | |
|---|---|
| set | REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 |
| setSize | 40 |
| pANOVA | 3.58e-07 |
| s.dist | 0.465 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT
| 99 | |
|---|---|
| set | REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT |
| setSize | 42 |
| pANOVA | 3.49e-07 |
| s.dist | 0.455 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cdc25a | 1158 |
| Atm | 1039 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1
| 280 | |
|---|---|
| set | REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 |
| setSize | 42 |
| pANOVA | 3.77e-07 |
| s.dist | 0.453 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Atm | 1039 |
| Psmd3 | 928 |
| Trp53 | 904 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
| 271 | |
|---|---|
| set | REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX |
| setSize | 45 |
| pANOVA | 2.84e-07 |
| s.dist | 0.443 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Gmnn | 2820 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Gmnn | 2820 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Orc5 | 2150 |
| Orc4 | 2125 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Orc2 | -517 |
| Orc3 | -613 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC
| 153 | |
|---|---|
| set | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC |
| setSize | 43 |
| pANOVA | 8.27e-07 |
| s.dist | 0.435 |
| p.adjustANOVA | 2.85e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Odc1 | 4409 |
| Nqo1 | 4289 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Odc1 | 4409 |
| Nqo1 | 4289 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Psma2 | -1441 |
| Oaz1 | -2639 |
| Oaz2 | -2731 |
| Psme1 | -2898 |
| Azin1 | -4552 |
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
| 442 | |
|---|---|
| set | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC |
| setSize | 14 |
| pANOVA | 0.00491 |
| s.dist | 0.434 |
| p.adjustANOVA | 0.0315 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Sec31a | 4489 |
| Hspa5 | 4263 |
| Sar1b | 4249 |
| B2m | 4181 |
| Canx | 4090 |
| Erap1 | 3896 |
| Tap2 | 3593 |
| Sec23a | 3419 |
| Calr | 2461 |
| Sec24d | 634 |
| Sec24c | -536 |
| Sec13 | -866 |
| Sec24b | -1791 |
| Pdia3 | -3877 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Sec31a | 4489 |
| Hspa5 | 4263 |
| Sar1b | 4249 |
| B2m | 4181 |
| Canx | 4090 |
| Erap1 | 3896 |
| Tap2 | 3593 |
| Sec23a | 3419 |
| Calr | 2461 |
| Sec24d | 634 |
| Sec24c | -536 |
| Sec13 | -866 |
| Sec24b | -1791 |
| Pdia3 | -3877 |
REACTOME_ER_PHAGOSOME_PATHWAY
| 30 | |
|---|---|
| set | REACTOME_ER_PHAGOSOME_PATHWAY |
| setSize | 48 |
| pANOVA | 2.1e-07 |
| s.dist | 0.433 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| B2m | 4181 |
| Psmc3 | 3975 |
| Sec61g | 3713 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Tap2 | 3593 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Sec61a1 | 2901 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| B2m | 4181 |
| Psmc3 | 3975 |
| Sec61g | 3713 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Tap2 | 3593 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Sec61a1 | 2901 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Calr | 2461 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Sec61a2 | 568 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
| Sec61b | -3533 |
| Pdia3 | -3877 |
REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
| 460 | |
|---|---|
| set | REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G |
| setSize | 42 |
| pANOVA | 1.26e-06 |
| s.dist | 0.432 |
| p.adjustANOVA | 3.48e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Rbx1 | 195 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Cul5 | -2341 |
| Psme1 | -2898 |
REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI
| 462 | |
|---|---|
| set | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI |
| setSize | 13 |
| pANOVA | 0.00697 |
| s.dist | -0.432 |
| p.adjustANOVA | 0.0398 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Pigx | -4574 |
| Sema6d | -4043 |
| Pigv | -3345 |
| Pigm | -3274 |
| Pigb | -3269 |
| Pigw | -2460 |
| Pign | -2287 |
| Dpm2 | -1587 |
| Pigg | -1373 |
| Pigc | -912 |
| Pigp | -648 |
| Pigo | -424 |
| Pigq | 1864 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Pigx | -4574 |
| Sema6d | -4043 |
| Pigv | -3345 |
| Pigm | -3274 |
| Pigb | -3269 |
| Pigw | -2460 |
| Pign | -2287 |
| Dpm2 | -1587 |
| Pigg | -1373 |
| Pigc | -912 |
| Pigp | -648 |
| Pigo | -424 |
| Pigq | 1864 |
REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
| 437 | |
|---|---|
| set | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS |
| setSize | 10 |
| pANOVA | 0.0234 |
| s.dist | -0.414 |
| p.adjustANOVA | 0.0995 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Kcnc3 | -3683 |
| Kcnq4 | -3622 |
| Kcng4 | -3316 |
| Kcnq5 | -3243 |
| Kcnc1 | -3054 |
| Kcna7 | -2551 |
| Kcnf1 | -2289 |
| Kcnc4 | -1343 |
| Kcnb1 | -788 |
| Kcnab1 | 4479 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Kcnc3 | -3683 |
| Kcnq4 | -3622 |
| Kcng4 | -3316 |
| Kcnq5 | -3243 |
| Kcnc1 | -3054 |
| Kcna7 | -2551 |
| Kcnf1 | -2289 |
| Kcnc4 | -1343 |
| Kcnb1 | -788 |
| Kcnab1 | 4479 |
REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX
| 335 | |
|---|---|
| set | REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX |
| setSize | 48 |
| pANOVA | 9.23e-07 |
| s.dist | 0.41 |
| p.adjustANOVA | 2.88e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Gmnn | 2820 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Gmnn | 2820 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Orc5 | 2150 |
| Orc4 | 2125 |
| Mcm2 | 2006 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Mcm7 | 999 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Orc2 | -517 |
| Orc3 | -613 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
| E2f3 | -4225 |
REACTOME_SIGNALING_BY_NOTCH4
| 66 | |
|---|---|
| set | REACTOME_SIGNALING_BY_NOTCH4 |
| setSize | 11 |
| pANOVA | 0.0189 |
| s.dist | -0.409 |
| p.adjustANOVA | 0.0834 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Adam10 | -4007 |
| Aph1b | -3705 |
| Jag2 | -3570 |
| Ncstn | -3211 |
| Dll4 | -3189 |
| Jag1 | -2545 |
| Psenen | -1249 |
| Aph1a | -301 |
| Notch4 | 123 |
| Psen2 | 182 |
| Psen1 | 388 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Adam10 | -4007 |
| Aph1b | -3705 |
| Jag2 | -3570 |
| Ncstn | -3211 |
| Dll4 | -3189 |
| Jag1 | -2545 |
| Psenen | -1249 |
| Aph1a | -301 |
| Notch4 | 123 |
| Psen2 | 182 |
| Psen1 | 388 |
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN
| 46 | |
|---|---|
| set | REACTOME_ORC1_REMOVAL_FROM_CHROMATIN |
| setSize | 49 |
| pANOVA | 9.92e-07 |
| s.dist | 0.404 |
| p.adjustANOVA | 2.9e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Orc5 | 2150 |
| Orc4 | 2125 |
| Mcm2 | 2006 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Mcm7 | 999 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Orc2 | -517 |
| Orc3 | -613 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Rb1 | -1562 |
| Cdkn1b | -2590 |
| Psme1 | -2898 |
REACTOME_SIGNALING_BY_NOTCH3
| 80 | |
|---|---|
| set | REACTOME_SIGNALING_BY_NOTCH3 |
| setSize | 11 |
| pANOVA | 0.0208 |
| s.dist | -0.403 |
| p.adjustANOVA | 0.0903 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Adam10 | -4007 |
| Aph1b | -3705 |
| Jag2 | -3570 |
| Ncstn | -3211 |
| Dll4 | -3189 |
| Jag1 | -2545 |
| Psenen | -1249 |
| Aph1a | -301 |
| Psen2 | 182 |
| Psen1 | 388 |
| Notch3 | 450 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Adam10 | -4007 |
| Aph1b | -3705 |
| Jag2 | -3570 |
| Ncstn | -3211 |
| Dll4 | -3189 |
| Jag1 | -2545 |
| Psenen | -1249 |
| Aph1a | -301 |
| Psen2 | 182 |
| Psen1 | 388 |
| Notch3 | 450 |
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21
| 456 | |
|---|---|
| set | REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 |
| setSize | 43 |
| pANOVA | 5.35e-06 |
| s.dist | 0.401 |
| p.adjustANOVA | 0.000125 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cul1 | 1053 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Cdkn1b | -2590 |
| Psme1 | -2898 |
| Ccne2 | -3785 |
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION
| 26 | |
|---|---|
| set | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION |
| setSize | 56 |
| pANOVA | 2.6e-07 |
| s.dist | 0.398 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Ctss | 4642 |
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Cyba | 4539 |
| Psmd2 | 4526 |
| Mrc1 | 4525 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| B2m | 4181 |
| Psmc3 | 3975 |
| Sec61g | 3713 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Tap2 | 3593 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Ctss | 4642 |
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Cyba | 4539 |
| Psmd2 | 4526 |
| Mrc1 | 4525 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| B2m | 4181 |
| Psmc3 | 3975 |
| Sec61g | 3713 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Tap2 | 3593 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Sec61a1 | 2901 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Calr | 2461 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Lnpep | 993 |
| Psmd3 | 928 |
| Sec61a2 | 568 |
| Itgb5 | 129 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Cd36 | -1230 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Itgav | -2555 |
| Psme1 | -2898 |
| Sec61b | -3533 |
| Pdia3 | -3877 |
| Mrc2 | -4223 |
REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
| 178 | |
|---|---|
| set | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION |
| setSize | 22 |
| pANOVA | 0.00135 |
| s.dist | 0.395 |
| p.adjustANOVA | 0.0115 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Eprs | 4636 |
| Tars | 4567 |
| Lars | 4566 |
| Rars | 4458 |
| Aars | 3807 |
| Farsb | 3655 |
| Aimp2 | 3522 |
| Nars | 3338 |
| Qars | 3271 |
| Aimp1 | 2179 |
| Cars | 2030 |
| Sars | 1773 |
| Gars | 1590 |
| Ppa1 | 1413 |
| Iars | 1336 |
| Yars | 976 |
| Vars | 749 |
| Wars | -871 |
| Dars | -969 |
| Kars | -1623 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Eprs | 4636 |
| Tars | 4567 |
| Lars | 4566 |
| Rars | 4458 |
| Aars | 3807 |
| Farsb | 3655 |
| Aimp2 | 3522 |
| Nars | 3338 |
| Qars | 3271 |
| Aimp1 | 2179 |
| Cars | 2030 |
| Sars | 1773 |
| Gars | 1590 |
| Ppa1 | 1413 |
| Iars | 1336 |
| Yars | 976 |
| Vars | 749 |
| Wars | -871 |
| Dars | -969 |
| Kars | -1623 |
| Hars | -1850 |
| Farsa | -2318 |
REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
| 415 | |
|---|---|
| set | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C |
| setSize | 53 |
| pANOVA | 6.93e-07 |
| s.dist | 0.395 |
| p.adjustANOVA | 2.7e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Cdc26 | 2233 |
| Ube2e1 | 2008 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Anapc2 | 1831 |
| Ube2c | 1566 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Anapc5 | 1205 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cdc16 | 1112 |
| Psmd3 | 928 |
| Anapc11 | 885 |
| Ube2d1 | 657 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Anapc10 | -2693 |
| Anapc7 | -2719 |
| Cdc27 | -2753 |
| Psme1 | -2898 |
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
| 169 | |
|---|---|
| set | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS |
| setSize | 11 |
| pANOVA | 0.0251 |
| s.dist | -0.39 |
| p.adjustANOVA | 0.104 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Aplnr | -4268 |
| Cxcl12 | -4167 |
| Ednrb | -3596 |
| F2r | -3039 |
| Agt | -2999 |
| Ccl25 | -2653 |
| Ccl27a | -2327 |
| Anxa1 | -763 |
| Ccl11 | -452 |
| App | 1284 |
| C3 | 2856 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Aplnr | -4268 |
| Cxcl12 | -4167 |
| Ednrb | -3596 |
| F2r | -3039 |
| Agt | -2999 |
| Ccl25 | -2653 |
| Ccl27a | -2327 |
| Anxa1 | -763 |
| Ccl11 | -452 |
| App | 1284 |
| C3 | 2856 |
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE
| 196 | |
|---|---|
| set | REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE |
| setSize | 46 |
| pANOVA | 6.23e-06 |
| s.dist | 0.385 |
| p.adjustANOVA | 0.000133 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Atm | 1039 |
| Psmd3 | 928 |
| Trp53 | 904 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Cdkn1b | -2590 |
| Psme1 | -2898 |
| Mdm2 | -3214 |
| Ccne2 | -3785 |
REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
| 412 | |
|---|---|
| set | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 |
| setSize | 56 |
| pANOVA | 6.29e-07 |
| s.dist | 0.385 |
| p.adjustANOVA | 2.68e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Cdc26 | 2233 |
| Ube2e1 | 2008 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Anapc2 | 1831 |
| Ube2c | 1566 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Anapc5 | 1205 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cdc16 | 1112 |
| Psmd3 | 928 |
| Anapc11 | 885 |
| Ube2d1 | 657 |
| Pttg1 | 527 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Aurka | -1930 |
| Anapc10 | -2693 |
| Anapc7 | -2719 |
| Cdc27 | -2753 |
| Psme1 | -2898 |
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
| 171 | |
|---|---|
| set | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS |
| setSize | 17 |
| pANOVA | 0.00614 |
| s.dist | -0.384 |
| p.adjustANOVA | 0.0359 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| S1pr1 | -4663 |
| Lpar1 | -4537 |
| Aplnr | -4268 |
| Cxcl12 | -4167 |
| P2ry2 | -3810 |
| Ednrb | -3596 |
| F2r | -3039 |
| Agt | -2999 |
| Ccl25 | -2653 |
| Adrb2 | -2373 |
| Ccl27a | -2327 |
| Anxa1 | -763 |
| Ccl11 | -452 |
| App | 1284 |
| P2ry1 | 1764 |
| C3 | 2856 |
| Lpar6 | 3150 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| S1pr1 | -4663 |
| Lpar1 | -4537 |
| Aplnr | -4268 |
| Cxcl12 | -4167 |
| P2ry2 | -3810 |
| Ednrb | -3596 |
| F2r | -3039 |
| Agt | -2999 |
| Ccl25 | -2653 |
| Adrb2 | -2373 |
| Ccl27a | -2327 |
| Anxa1 | -763 |
| Ccl11 | -452 |
| App | 1284 |
| P2ry1 | 1764 |
| C3 | 2856 |
| Lpar6 | 3150 |
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE
| 299 | |
|---|---|
| set | REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE |
| setSize | 60 |
| pANOVA | 2.98e-07 |
| s.dist | 0.383 |
| p.adjustANOVA | 1.76e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Cdc14a | 4657 |
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Btrc | 3826 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Cdc14a | 4657 |
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Btrc | 3826 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Cdc26 | 2233 |
| Ube2e1 | 2008 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Anapc2 | 1831 |
| Ube2c | 1566 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Anapc5 | 1205 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cdc16 | 1112 |
| Cul1 | 1053 |
| Psmd3 | 928 |
| Anapc11 | 885 |
| Ube2d1 | 657 |
| Pttg1 | 527 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Aurka | -1930 |
| Anapc10 | -2693 |
| Anapc7 | -2719 |
| Cdc27 | -2753 |
| Psme1 | -2898 |
| Bub3 | -3122 |
REACTOME_NCAM1_INTERACTIONS
| 230 | |
|---|---|
| set | REACTOME_NCAM1_INTERACTIONS |
| setSize | 15 |
| pANOVA | 0.0105 |
| s.dist | 0.382 |
| p.adjustANOVA | 0.0558 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Col1a2 | 4615 |
| Nrtn | 4581 |
| Col6a1 | 4540 |
| Col5a2 | 4414 |
| Col3a1 | 4358 |
| Col6a2 | 3458 |
| Col5a1 | 3388 |
| Col1a1 | 1723 |
| Col6a3 | 1666 |
| Prnp | 1580 |
| Col4a2 | 421 |
| Col4a1 | -409 |
| Cacnb1 | -1375 |
| Cacna1s | -2636 |
| Agrn | -3781 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Col1a2 | 4615 |
| Nrtn | 4581 |
| Col6a1 | 4540 |
| Col5a2 | 4414 |
| Col3a1 | 4358 |
| Col6a2 | 3458 |
| Col5a1 | 3388 |
| Col1a1 | 1723 |
| Col6a3 | 1666 |
| Prnp | 1580 |
| Col4a2 | 421 |
| Col4a1 | -409 |
| Cacnb1 | -1375 |
| Cacna1s | -2636 |
| Agrn | -3781 |
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS
| 414 | |
|---|---|
| set | REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS |
| setSize | 56 |
| pANOVA | 8.53e-07 |
| s.dist | 0.381 |
| p.adjustANOVA | 2.85e-05 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Anapc1 | 4389 |
| Psmc3 | 3975 |
| Anapc4 | 3890 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Cdc23 | 3236 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Cdc26 | 2233 |
| Ube2e1 | 2008 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Anapc2 | 1831 |
| Ube2c | 1566 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Anapc5 | 1205 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cdc16 | 1112 |
| Psmd3 | 928 |
| Anapc11 | 885 |
| Ube2d1 | 657 |
| Pttg1 | 527 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Anapc10 | -2693 |
| Anapc7 | -2719 |
| Cdc27 | -2753 |
| Psme1 | -2898 |
| Bub3 | -3122 |
REACTOME_POTASSIUM_CHANNELS
| 447 | |
|---|---|
| set | REACTOME_POTASSIUM_CHANNELS |
| setSize | 22 |
| pANOVA | 0.00259 |
| s.dist | -0.371 |
| p.adjustANOVA | 0.0186 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Kcnj2 | -4478 |
| Gnb1 | -4381 |
| Kcnc3 | -3683 |
| Kcnq4 | -3622 |
| Kcnn1 | -3590 |
| Kcnj8 | -3575 |
| Kcng4 | -3316 |
| Kcnq5 | -3243 |
| Gnb2 | -3171 |
| Kcnc1 | -3054 |
| Gabbr1 | -2843 |
| Kcna7 | -2551 |
| Kcnf1 | -2289 |
| Kcnj11 | -1483 |
| Kcnc4 | -1343 |
| Gng5 | -1318 |
| Kcnb1 | -788 |
| Abcc9 | 291 |
| Kcnj12 | 475 |
| Gng12 | 1918 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Kcnj2 | -4478 |
| Gnb1 | -4381 |
| Kcnc3 | -3683 |
| Kcnq4 | -3622 |
| Kcnn1 | -3590 |
| Kcnj8 | -3575 |
| Kcng4 | -3316 |
| Kcnq5 | -3243 |
| Gnb2 | -3171 |
| Kcnc1 | -3054 |
| Gabbr1 | -2843 |
| Kcna7 | -2551 |
| Kcnf1 | -2289 |
| Kcnj11 | -1483 |
| Kcnc4 | -1343 |
| Gng5 | -1318 |
| Kcnb1 | -788 |
| Abcc9 | 291 |
| Kcnj12 | 475 |
| Gng12 | 1918 |
| Gng10 | 3301 |
| Kcnab1 | 4479 |
REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0
| 373 | |
|---|---|
| set | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 |
| setSize | 45 |
| pANOVA | 1.74e-05 |
| s.dist | 0.371 |
| p.adjustANOVA | 0.00028 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Eif4g1 | 2401 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Hspa8 | -456 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Hnrnpd | -2254 |
| Psme1 | -2898 |
| Hspb1 | -4323 |
| Hspa1b | -4483 |
REACTOME_M_G1_TRANSITION
| 214 | |
|---|---|
| set | REACTOME_M_G1_TRANSITION |
| setSize | 51 |
| pANOVA | 4.89e-06 |
| s.dist | 0.37 |
| p.adjustANOVA | 0.00012 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Gmnn | 2820 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Gmnn | 2820 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Orc5 | 2150 |
| Orc4 | 2125 |
| Mcm2 | 2006 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Mcm7 | 999 |
| Psmd3 | 928 |
| Rpa1 | 669 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Rpa2 | -393 |
| Orc2 | -517 |
| Orc3 | -613 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Psme1 | -2898 |
| Pola2 | -3981 |
| E2f3 | -4225 |
REACTOME_SIGNALING_BY_NOTCH2
| 72 | |
|---|---|
| set | REACTOME_SIGNALING_BY_NOTCH2 |
| setSize | 11 |
| pANOVA | 0.0354 |
| s.dist | -0.366 |
| p.adjustANOVA | 0.136 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Adam10 | -4007 |
| Aph1b | -3705 |
| Jag2 | -3570 |
| Ncstn | -3211 |
| Dll4 | -3189 |
| Jag1 | -2545 |
| Psenen | -1249 |
| Aph1a | -301 |
| Psen2 | 182 |
| Psen1 | 388 |
| Notch2 | 2303 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Adam10 | -4007 |
| Aph1b | -3705 |
| Jag2 | -3570 |
| Ncstn | -3211 |
| Dll4 | -3189 |
| Jag1 | -2545 |
| Psenen | -1249 |
| Aph1a | -301 |
| Psen2 | 182 |
| Psen1 | 388 |
| Notch2 | 2303 |
REACTOME_REGULATION_OF_APOPTOSIS
| 156 | |
|---|---|
| set | REACTOME_REGULATION_OF_APOPTOSIS |
| setSize | 48 |
| pANOVA | 1.39e-05 |
| s.dist | 0.363 |
| p.adjustANOVA | 0.00024 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Unc5a | 3730 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Dapk1 | 2918 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Unc5a | 3730 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Dapk1 | 2918 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Psmd3 | 928 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Dapk2 | -459 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Appl1 | -1803 |
| Dapk3 | -2219 |
| Arhgap10 | -2402 |
| Maged1 | -2494 |
| Psme1 | -2898 |
| Pak2 | -2964 |
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION
| 251 | |
|---|---|
| set | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION |
| setSize | 10 |
| pANOVA | 0.0474 |
| s.dist | -0.362 |
| p.adjustANOVA | 0.165 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Hsp90aa1 | -3978 |
| Nrp1 | -3867 |
| Plxna2 | -3771 |
| Fyn | -2995 |
| Pak2 | -2964 |
| Plxna1 | -1163 |
| Pak1 | -873 |
| Rac1 | -252 |
| Cfl1 | 1350 |
| Hsp90ab1 | 1523 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Hsp90aa1 | -3978 |
| Nrp1 | -3867 |
| Plxna2 | -3771 |
| Fyn | -2995 |
| Pak2 | -2964 |
| Plxna1 | -1163 |
| Pak1 | -873 |
| Rac1 | -252 |
| Cfl1 | 1350 |
| Hsp90ab1 | 1523 |
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS
| 68 | |
|---|---|
| set | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS |
| setSize | 53 |
| pANOVA | 9.18e-06 |
| s.dist | 0.353 |
| p.adjustANOVA | 0.000172 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Btrc | 3826 |
| Bcl10 | 3733 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Btrc | 3826 |
| Bcl10 | 3733 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Ikbkb | 2021 |
| Psma6 | 1945 |
| Fbxw11 | 1934 |
| Rela | 1888 |
| Psmd6 | 1849 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cul1 | 1053 |
| Psmd3 | 928 |
| Chuk | 173 |
| Ikbkg | 41 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Nfkbib | -1936 |
| Psme1 | -2898 |
| Nfkbia | -2910 |
| Rel | -3113 |
| Map3k7 | -3155 |
| Malt1 | -3461 |
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING
| 32 | |
|---|---|
| set | REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING |
| setSize | 18 |
| pANOVA | 0.0108 |
| s.dist | -0.347 |
| p.adjustANOVA | 0.056 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Fgf2 | -4518 |
| Spry2 | -4075 |
| Fgf6 | -3982 |
| Mapk3 | -3203 |
| Fgfr1 | -3163 |
| Braf | -2822 |
| Fgfr3 | -2384 |
| Ppp2r1a | -2213 |
| Frs2 | -2062 |
| Cbl | -1558 |
| Grb2 | -1540 |
| Mapk1 | -1516 |
| Rps27a | -1248 |
| Mknk1 | -408 |
| Uba52 | -285 |
| Fgf1 | 1167 |
| Ppp2ca | 1474 |
| Ppp2cb | 3025 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Fgf2 | -4518 |
| Spry2 | -4075 |
| Fgf6 | -3982 |
| Mapk3 | -3203 |
| Fgfr1 | -3163 |
| Braf | -2822 |
| Fgfr3 | -2384 |
| Ppp2r1a | -2213 |
| Frs2 | -2062 |
| Cbl | -1558 |
| Grb2 | -1540 |
| Mapk1 | -1516 |
| Rps27a | -1248 |
| Mknk1 | -408 |
| Uba52 | -285 |
| Fgf1 | 1167 |
| Ppp2ca | 1474 |
| Ppp2cb | 3025 |
REACTOME_COMPLEMENT_CASCADE
| 430 | |
|---|---|
| set | REACTOME_COMPLEMENT_CASCADE |
| setSize | 11 |
| pANOVA | 0.0512 |
| s.dist | 0.34 |
| p.adjustANOVA | 0.175 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| C1qc | 4597 |
| C1qa | 4588 |
| Cd46 | 4516 |
| C1qb | 4219 |
| C3 | 2856 |
| C4b | 1987 |
| Cr1l | 1017 |
| Cfd | 380 |
| Pros1 | -1550 |
| C7 | -2299 |
| C1s1 | -3001 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| C1qc | 4597 |
| C1qa | 4588 |
| Cd46 | 4516 |
| C1qb | 4219 |
| C3 | 2856 |
| C4b | 1987 |
| Cr1l | 1017 |
| Cfd | 380 |
| Pros1 | -1550 |
| C7 | -2299 |
| C1s1 | -3001 |
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_
| 194 | |
|---|---|
| set | REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ |
| setSize | 50 |
| pANOVA | 4.31e-05 |
| s.dist | 0.335 |
| p.adjustANOVA | 0.00065 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Bmyc | 2120 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Ccnh | 1551 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cdc25a | 1158 |
| Cul1 | 1053 |
| Psmd3 | 928 |
| Cdk7 | 404 |
| Psmb4 | 31 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Rb1 | -1562 |
| Mnat1 | -1709 |
| Cdkn1b | -2590 |
| Psme1 | -2898 |
| Ccne2 | -3785 |
| Max | -4519 |
REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS
| 270 | |
|---|---|
| set | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS |
| setSize | 15 |
| pANOVA | 0.0254 |
| s.dist | -0.334 |
| p.adjustANOVA | 0.104 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Slc16a10 | -4670 |
| Slc38a2 | -4594 |
| Slc43a1 | -4444 |
| Slc6a6 | -4373 |
| Slc38a4 | -4282 |
| Slc38a3 | -3685 |
| Slc15a2 | -2395 |
| Slc15a4 | -2328 |
| Slc3a2 | -1898 |
| Slc43a2 | -900 |
| Slc36a1 | 510 |
| Slc7a8 | 1133 |
| Slc7a6 | 1156 |
| Slc1a5 | 2814 |
| Slc7a2 | 4486 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Slc16a10 | -4670 |
| Slc38a2 | -4594 |
| Slc43a1 | -4444 |
| Slc6a6 | -4373 |
| Slc38a4 | -4282 |
| Slc38a3 | -3685 |
| Slc15a2 | -2395 |
| Slc15a4 | -2328 |
| Slc3a2 | -1898 |
| Slc43a2 | -900 |
| Slc36a1 | 510 |
| Slc7a8 | 1133 |
| Slc7a6 | 1156 |
| Slc1a5 | 2814 |
| Slc7a2 | 4486 |
REACTOME_SYNTHESIS_OF_DNA
| 274 | |
|---|---|
| set | REACTOME_SYNTHESIS_OF_DNA |
| setSize | 61 |
| pANOVA | 6.87e-06 |
| s.dist | 0.333 |
| p.adjustANOVA | 0.00014 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Pold1 | 4533 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Pold3 | 3638 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Pold1 | 4533 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Psmb7 | 3709 |
| Pold3 | 3638 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Cdkn1a | 3415 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Gins2 | 2480 |
| Psmc6 | 2477 |
| Pold2 | 2278 |
| Psmc2 | 2272 |
| Orc5 | 2150 |
| Orc4 | 2125 |
| Mcm2 | 2006 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Rfc2 | 1790 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Mcm7 | 999 |
| Psmd3 | 928 |
| Rpa1 | 669 |
| Psmb4 | 31 |
| Pcna | -167 |
| Uba52 | -285 |
| Rpa2 | -393 |
| Orc2 | -517 |
| Orc3 | -613 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Gins4 | -1510 |
| Rb1 | -1562 |
| Cdkn1b | -2590 |
| Pold4 | -2779 |
| Psme1 | -2898 |
| Pola2 | -3981 |
| Rfc4 | -4380 |
REACTOME_GLUCOSE_METABOLISM
| 435 | |
|---|---|
| set | REACTOME_GLUCOSE_METABOLISM |
| setSize | 43 |
| pANOVA | 0.000174 |
| s.dist | 0.331 |
| p.adjustANOVA | 0.00232 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Pfkfb4 | 4634 |
| Pgk1 | 4587 |
| Pcx | 4568 |
| Pfkfb1 | 4411 |
| Phka1 | 4400 |
| Agl | 4381 |
| Phkb | 4377 |
| Eno3 | 4362 |
| Fbp2 | 4341 |
| Phka2 | 4305 |
| Eno1 | 4244 |
| Pygm | 4193 |
| Gpi1 | 3899 |
| Phkg1 | 3814 |
| Mdh1 | 3335 |
| Phkg2 | 3164 |
| Ppp2cb | 3025 |
| Pfkfb2 | 2951 |
| Pgm1 | 2888 |
| Pfkm | 2853 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Pfkfb4 | 4634 |
| Pgk1 | 4587 |
| Pcx | 4568 |
| Pfkfb1 | 4411 |
| Phka1 | 4400 |
| Agl | 4381 |
| Phkb | 4377 |
| Eno3 | 4362 |
| Fbp2 | 4341 |
| Phka2 | 4305 |
| Eno1 | 4244 |
| Pygm | 4193 |
| Gpi1 | 3899 |
| Phkg1 | 3814 |
| Mdh1 | 3335 |
| Phkg2 | 3164 |
| Ppp2cb | 3025 |
| Pfkfb2 | 2951 |
| Pgm1 | 2888 |
| Pfkm | 2853 |
| Gyg | 2567 |
| Slc25a12 | 2098 |
| Tpi1 | 1985 |
| Ugp2 | 1869 |
| Gbe1 | 1815 |
| Prkacb | 1528 |
| Ppp2ca | 1474 |
| Ppp2r5d | 606 |
| Calm1 | -190 |
| Mdh2 | -555 |
| Pfkfb3 | -561 |
| Slc25a11 | -1121 |
| Gys1 | -1223 |
| Got2 | -1281 |
| Pgam1 | -1864 |
| Ppp2r1b | -2072 |
| Prkaca | -2089 |
| Ppp2r1a | -2213 |
| Pgam2 | -2214 |
| Pygb | -2481 |
| Pfkp | -2749 |
| Pfkl | -2961 |
| Got1 | -3342 |
REACTOME_GPCR_LIGAND_BINDING
| 309 | |
|---|---|
| set | REACTOME_GPCR_LIGAND_BINDING |
| setSize | 42 |
| pANOVA | 0.000212 |
| s.dist | -0.331 |
| p.adjustANOVA | 0.00276 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| S1pr1 | -4663 |
| Crhr2 | -4588 |
| Lpar1 | -4537 |
| Ramp1 | -4436 |
| Fzd4 | -4416 |
| Gnb1 | -4381 |
| Wnt5a | -4274 |
| Aplnr | -4268 |
| Cxcl12 | -4167 |
| P2ry2 | -3810 |
| Ednrb | -3596 |
| Fzd7 | -3499 |
| Wnt9a | -3267 |
| Sctr | -3245 |
| Wnt11 | -3172 |
| Gnb2 | -3171 |
| F2r | -3039 |
| Gnb4 | -3034 |
| Agt | -2999 |
| Gabbr1 | -2843 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| S1pr1 | -4663 |
| Crhr2 | -4588 |
| Lpar1 | -4537 |
| Ramp1 | -4436 |
| Fzd4 | -4416 |
| Gnb1 | -4381 |
| Wnt5a | -4274 |
| Aplnr | -4268 |
| Cxcl12 | -4167 |
| P2ry2 | -3810 |
| Ednrb | -3596 |
| Fzd7 | -3499 |
| Wnt9a | -3267 |
| Sctr | -3245 |
| Wnt11 | -3172 |
| Gnb2 | -3171 |
| F2r | -3039 |
| Gnb4 | -3034 |
| Agt | -2999 |
| Gabbr1 | -2843 |
| Ccl25 | -2653 |
| Ramp2 | -2509 |
| Adrb2 | -2373 |
| Gnb5 | -2348 |
| Ccl27a | -2327 |
| Gnas | -1853 |
| Gng5 | -1318 |
| Anxa1 | -763 |
| Casr | -669 |
| Ccl11 | -452 |
| Gng11 | -402 |
| Fzd9 | 400 |
| Calcrl | 779 |
| App | 1284 |
| P2ry1 | 1764 |
| Gng12 | 1918 |
| C3 | 2856 |
| Lpar6 | 3150 |
| Gng10 | 3301 |
| Fzd6 | 3625 |
| Ptch1 | 4460 |
| Wnt4 | 4578 |
REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS
| 243 | |
|---|---|
| set | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS |
| setSize | 20 |
| pANOVA | 0.0108 |
| s.dist | -0.33 |
| p.adjustANOVA | 0.056 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Pigx | -4574 |
| Sema6d | -4043 |
| Pigv | -3345 |
| Pigm | -3274 |
| Pigb | -3269 |
| Pigt | -2862 |
| Dpm3 | -2734 |
| Pigw | -2460 |
| Pign | -2287 |
| Gpaa1 | -2149 |
| Dpm2 | -1587 |
| Pigk | -1439 |
| Pigg | -1373 |
| Pigu | -1335 |
| Pigc | -912 |
| Pigp | -648 |
| Pigo | -424 |
| Pigq | 1864 |
| Gm20716 | 1996 |
| Pigs | 3944 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Pigx | -4574 |
| Sema6d | -4043 |
| Pigv | -3345 |
| Pigm | -3274 |
| Pigb | -3269 |
| Pigt | -2862 |
| Dpm3 | -2734 |
| Pigw | -2460 |
| Pign | -2287 |
| Gpaa1 | -2149 |
| Dpm2 | -1587 |
| Pigk | -1439 |
| Pigg | -1373 |
| Pigu | -1335 |
| Pigc | -912 |
| Pigp | -648 |
| Pigo | -424 |
| Pigq | 1864 |
| Gm20716 | 1996 |
| Pigs | 3944 |
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS
| 257 | |
|---|---|
| set | REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS |
| setSize | 24 |
| pANOVA | 0.00538 |
| s.dist | -0.328 |
| p.adjustANOVA | 0.0332 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Slc2a1 | -4409 |
| Slc6a6 | -4373 |
| Slc30a5 | -3998 |
| Slc30a1 | -3988 |
| Slc2a8 | -3891 |
| Slc2a3 | -3875 |
| Slc39a1 | -3322 |
| Slc44a1 | -3178 |
| Slc22a5 | -3066 |
| Slc47a1 | -2767 |
| Slc30a2 | -2596 |
| Cp | -2591 |
| Slc41a1 | -1613 |
| Slc30a7 | -1018 |
| Slc2a4 | -706 |
| Slc40a1 | -699 |
| Slc2a12 | -579 |
| Slc44a2 | -192 |
| Slc16a1 | 234 |
| Slc31a1 | 841 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Slc2a1 | -4409 |
| Slc6a6 | -4373 |
| Slc30a5 | -3998 |
| Slc30a1 | -3988 |
| Slc2a8 | -3891 |
| Slc2a3 | -3875 |
| Slc39a1 | -3322 |
| Slc44a1 | -3178 |
| Slc22a5 | -3066 |
| Slc47a1 | -2767 |
| Slc30a2 | -2596 |
| Cp | -2591 |
| Slc41a1 | -1613 |
| Slc30a7 | -1018 |
| Slc2a4 | -706 |
| Slc40a1 | -699 |
| Slc2a12 | -579 |
| Slc44a2 | -192 |
| Slc16a1 | 234 |
| Slc31a1 | 841 |
| Slc39a7 | 1174 |
| Slc16a3 | 2290 |
| Slc39a3 | 2405 |
| Slc39a10 | 2978 |
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS
| 313 | |
|---|---|
| set | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS |
| setSize | 17 |
| pANOVA | 0.0194 |
| s.dist | -0.328 |
| p.adjustANOVA | 0.0849 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Gnb1 | -4381 |
| Gnaq | -3325 |
| Mapk3 | -3203 |
| Gnb2 | -3171 |
| F2r | -3039 |
| Gnb4 | -3034 |
| Arrb1 | -2665 |
| Gna11 | -2568 |
| Gna12 | -2449 |
| Gnb5 | -2348 |
| Gna13 | -1528 |
| Mapk1 | -1516 |
| Gng5 | -1318 |
| Gng11 | -402 |
| Gng12 | 1918 |
| Gng10 | 3301 |
| Arrb2 | 3602 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Gnb1 | -4381 |
| Gnaq | -3325 |
| Mapk3 | -3203 |
| Gnb2 | -3171 |
| F2r | -3039 |
| Gnb4 | -3034 |
| Arrb1 | -2665 |
| Gna11 | -2568 |
| Gna12 | -2449 |
| Gnb5 | -2348 |
| Gna13 | -1528 |
| Mapk1 | -1516 |
| Gng5 | -1318 |
| Gng11 | -402 |
| Gng12 | 1918 |
| Gng10 | 3301 |
| Arrb2 | 3602 |
REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR
| 288 | |
|---|---|
| set | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR |
| setSize | 11 |
| pANOVA | 0.0609 |
| s.dist | -0.326 |
| p.adjustANOVA | 0.193 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Gnb1 | -4381 |
| Gnaq | -3325 |
| Gnb2 | -3171 |
| Gnb4 | -3034 |
| Gna11 | -2568 |
| Gnb5 | -2348 |
| Gna13 | -1528 |
| Gng5 | -1318 |
| Gng11 | -402 |
| Gng12 | 1918 |
| Gng10 | 3301 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Gnb1 | -4381 |
| Gnaq | -3325 |
| Gnb2 | -3171 |
| Gnb4 | -3034 |
| Gna11 | -2568 |
| Gnb5 | -2348 |
| Gna13 | -1528 |
| Gng5 | -1318 |
| Gng11 | -402 |
| Gng12 | 1918 |
| Gng10 | 3301 |
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1
| 226 | |
|---|---|
| set | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 |
| setSize | 20 |
| pANOVA | 0.0116 |
| s.dist | -0.326 |
| p.adjustANOVA | 0.0584 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Rapgef3 | -4623 |
| Gnb1 | -4381 |
| Iqgap1 | -3787 |
| Itpr2 | -3745 |
| Gnb2 | -3171 |
| Gnb4 | -3034 |
| Adcy6 | -2533 |
| Gnb5 | -2348 |
| Prkar1a | -2321 |
| Prkaca | -2089 |
| Gnas | -1853 |
| Prkar2a | -1614 |
| Gng5 | -1318 |
| Kcnb1 | -788 |
| Gng11 | -402 |
| Rap1a | -111 |
| Rap1b | 784 |
| Prkacb | 1528 |
| Gng12 | 1918 |
| Gng10 | 3301 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Rapgef3 | -4623 |
| Gnb1 | -4381 |
| Iqgap1 | -3787 |
| Itpr2 | -3745 |
| Gnb2 | -3171 |
| Gnb4 | -3034 |
| Adcy6 | -2533 |
| Gnb5 | -2348 |
| Prkar1a | -2321 |
| Prkaca | -2089 |
| Gnas | -1853 |
| Prkar2a | -1614 |
| Gng5 | -1318 |
| Kcnb1 | -788 |
| Gng11 | -402 |
| Rap1a | -111 |
| Rap1b | 784 |
| Prkacb | 1528 |
| Gng12 | 1918 |
| Gng10 | 3301 |
REACTOME_SIGNALING_BY_WNT
| 13 | |
|---|---|
| set | REACTOME_SIGNALING_BY_WNT |
| setSize | 56 |
| pANOVA | 2.6e-05 |
| s.dist | 0.325 |
| p.adjustANOVA | 0.000406 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Ctnnb1 | 3934 |
| Btrc | 3826 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Ppp2cb | 3025 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Psmd9 | 4557 |
| Psmd1 | 4542 |
| Psmd2 | 4526 |
| Psmc1 | 4518 |
| Psma1 | 4465 |
| Psme4 | 4444 |
| Psmc3 | 3975 |
| Ctnnb1 | 3934 |
| Btrc | 3826 |
| Psmb7 | 3709 |
| Psmd7 | 3606 |
| Psmc4 | 3591 |
| Psma5 | 3558 |
| Psmb3 | 3341 |
| Psmb6 | 3260 |
| Psmd13 | 3187 |
| Psmb2 | 3126 |
| Ppp2cb | 3025 |
| Psmd11 | 3011 |
| Psmb5 | 2694 |
| Psmd10 | 2684 |
| Psma4 | 2636 |
| Psmd4 | 2622 |
| Psmd12 | 2603 |
| Psmc5 | 2576 |
| Psma3 | 2518 |
| Psmc6 | 2477 |
| Psmc2 | 2272 |
| Psma6 | 1945 |
| Psmd6 | 1849 |
| Frat2 | 1499 |
| Ppp2ca | 1474 |
| Psmd5 | 1427 |
| Psmd14 | 1216 |
| Psmb1 | 1183 |
| Psma7 | 1165 |
| Cul1 | 1053 |
| Psmd3 | 928 |
| Csnk1a1 | 773 |
| Ppp2r5d | 606 |
| Ppp2r5e | 601 |
| Psmb4 | 31 |
| Ppp2r5a | -115 |
| Uba52 | -285 |
| Psmd8 | -625 |
| Psmf1 | -783 |
| Psmb10 | -830 |
| Rps27a | -1248 |
| Psma2 | -1441 |
| Ppp2r1b | -2072 |
| Ppp2r1a | -2213 |
| Apc | -2703 |
| Ppp2r5c | -2823 |
| Psme1 | -2898 |
| Axin1 | -4468 |
| Ppp2r5b | -4539 |
REACTOME_GLUCONEOGENESIS
| 174 | |
|---|---|
| set | REACTOME_GLUCONEOGENESIS |
| setSize | 18 |
| pANOVA | 0.0178 |
| s.dist | 0.323 |
| p.adjustANOVA | 0.0824 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Pgk1 | 4587 |
| Pcx | 4568 |
| Pfkfb1 | 4411 |
| Eno3 | 4362 |
| Fbp2 | 4341 |
| Eno1 | 4244 |
| Gpi1 | 3899 |
| Mdh1 | 3335 |
| Slc25a12 | 2098 |
| Tpi1 | 1985 |
| Prkacb | 1528 |
| Mdh2 | -555 |
| Slc25a11 | -1121 |
| Got2 | -1281 |
| Pgam1 | -1864 |
| Prkaca | -2089 |
| Pgam2 | -2214 |
| Got1 | -3342 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Pgk1 | 4587 |
| Pcx | 4568 |
| Pfkfb1 | 4411 |
| Eno3 | 4362 |
| Fbp2 | 4341 |
| Eno1 | 4244 |
| Gpi1 | 3899 |
| Mdh1 | 3335 |
| Slc25a12 | 2098 |
| Tpi1 | 1985 |
| Prkacb | 1528 |
| Mdh2 | -555 |
| Slc25a11 | -1121 |
| Got2 | -1281 |
| Pgam1 | -1864 |
| Prkaca | -2089 |
| Pgam2 | -2214 |
| Got1 | -3342 |
REACTOME_SIGNAL_AMPLIFICATION
| 277 | |
|---|---|
| set | REACTOME_SIGNAL_AMPLIFICATION |
| setSize | 15 |
| pANOVA | 0.0325 |
| s.dist | -0.319 |
| p.adjustANOVA | 0.127 |
Top enriched genes
| GeneID | Gene Rank |
|---|---|
| Gnb1 | -4381 |
| Gnai3 | -3866 |
| Gnaq | -3325 |
| Gnb2 | -3171 |
| Gnb4 | -3034 |
| Gna11 | -2568 |
| Mapk14 | -2526 |
| Gnb5 | -2348 |
| Gna13 | -1528 |
| Gng5 | -1318 |
| Gnai2 | -974 |
| Gng11 | -402 |
| P2ry1 | 1764 |
| Gng12 | 1918 |
| Gng10 | 3301 |
Click HERE to show all gene set members
| GeneID | Gene Rank |
|---|---|
| Gnb1 | -4381 |
| Gnai3 | -3866 |
| Gnaq | -3325 |
| Gnb2 | -3171 |
| Gnb4 | -3034 |
| Gna11 | -2568 |
| Mapk14 | -2526 |
| Gnb5 | -2348 |
| Gna13 | -1528 |
| Gng5 | -1318 |
| Gnai2 | -974 |
| Gng11 | -402 |
| P2ry1 | 1764 |
| Gng12 | 1918 |
| Gng10 | 3301 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] plyr_1.8.7 pkgload_1.3.0
## [3] GGally_2.1.2 gtools_3.9.2.2
## [5] echarts4r_0.4.4 beeswarm_0.4.0
## [7] vioplot_0.3.7 sm_2.2-5.7
## [9] kableExtra_1.3.4 topconfects_1.12.0
## [11] limma_3.52.1 eulerr_6.1.1
## [13] mitch_1.8.0 MASS_7.3-58
## [15] fgsea_1.22.0 gplots_3.1.3
## [17] DESeq2_1.36.0 SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0 MatrixGenerics_1.8.0
## [21] matrixStats_0.62.0 GenomicRanges_1.48.0
## [23] GenomeInfoDb_1.32.2 IRanges_2.30.0
## [25] S4Vectors_0.34.0 BiocGenerics_0.42.0
## [27] reshape2_1.4.4 forcats_0.5.1
## [29] stringr_1.4.0 dplyr_1.0.9
## [31] purrr_0.3.4 readr_2.1.2
## [33] tidyr_1.2.0 tibble_3.1.7
## [35] ggplot2_3.3.6 tidyverse_1.3.1
## [37] zoo_1.8-10
##
## loaded via a namespace (and not attached):
## [1] readxl_1.4.0 backports_1.4.1 fastmatch_1.1-3
## [4] systemfonts_1.0.4 splines_4.2.1 BiocParallel_1.30.3
## [7] digest_0.6.29 htmltools_0.5.2 fansi_1.0.3
## [10] magrittr_2.0.3 memoise_2.0.1 tzdb_0.3.0
## [13] Biostrings_2.64.0 annotate_1.74.0 modelr_0.1.8
## [16] svglite_2.1.0 prettyunits_1.1.1 colorspace_2.0-3
## [19] blob_1.2.3 rvest_1.0.2 haven_2.5.0
## [22] xfun_0.31 crayon_1.5.1 RCurl_1.98-1.7
## [25] jsonlite_1.8.0 genefilter_1.78.0 survival_3.4-0
## [28] glue_1.6.2 gtable_0.3.0 zlibbioc_1.42.0
## [31] XVector_0.36.0 webshot_0.5.3 DelayedArray_0.22.0
## [34] scales_1.2.0 DBI_1.1.3 Rcpp_1.0.8.3
## [37] viridisLite_0.4.0 xtable_1.8-4 progress_1.2.2
## [40] bit_4.0.4 htmlwidgets_1.5.4 httr_1.4.3
## [43] RColorBrewer_1.1-3 ellipsis_0.3.2 pkgconfig_2.0.3
## [46] reshape_0.8.9 XML_3.99-0.10 farver_2.1.0
## [49] sass_0.4.1 dbplyr_2.2.1 locfit_1.5-9.5
## [52] utf8_1.2.2 tidyselect_1.1.2 labeling_0.4.2
## [55] rlang_1.0.3 later_1.3.0 AnnotationDbi_1.58.0
## [58] munsell_0.5.0 cellranger_1.1.0 tools_4.2.1
## [61] cachem_1.0.6 cli_3.3.0 generics_0.1.2
## [64] RSQLite_2.2.14 broom_0.8.0 evaluate_0.15
## [67] fastmap_1.1.0 yaml_2.3.5 knitr_1.39
## [70] bit64_4.0.5 fs_1.5.2 caTools_1.18.2
## [73] KEGGREST_1.36.2 mime_0.12 xml2_1.3.3
## [76] compiler_4.2.1 rstudioapi_0.13 png_0.1-7
## [79] reprex_2.0.1 geneplotter_1.74.0 bslib_0.3.1
## [82] stringi_1.7.6 highr_0.9 lattice_0.20-45
## [85] Matrix_1.4-1 vctrs_0.4.1 pillar_1.7.0
## [88] lifecycle_1.0.1 jquerylib_0.1.4 data.table_1.14.2
## [91] bitops_1.0-7 httpuv_1.6.5 R6_2.5.1
## [94] promises_1.2.0.1 KernSmooth_2.23-20 gridExtra_2.3
## [97] codetools_0.2-18 assertthat_0.2.1 withr_2.5.0
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1 hms_1.1.1
## [103] grid_4.2.1 rmarkdown_2.14 shiny_1.7.1
## [106] lubridate_1.8.0END of report