date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     stat
## 0610009B22Rik -0.5488684
## 0610009L18Rik  0.7010761
## 0610010K14Rik -0.2062781
## 0610012G03Rik -1.0685616
## 0610030E20Rik  1.0067021
## 0610040J01Rik -0.6151338
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 674
num_genes_in_profile 9606
duplicated_genes_present 0
num_profile_genes_in_sets 2837
num_profile_genes_not_in_sets 6769

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt
Gene sets metrics
Gene sets metrics
num_genesets 674
num_genesets_excluded 201
num_genesets_included 473

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 3.07e-09 -0.785 8.54e-08
REACTOME PEPTIDE CHAIN ELONGATION 67 1.43e-23 0.707 1.69e-21
REACTOME RESPIRATORY ELECTRON TRANSPORT 59 3.97e-20 -0.691 2.68e-18
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 4.00e-05 -0.685 8.59e-04
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 2.58e-05 -0.674 5.82e-04
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 42 4.49e-14 0.673 1.77e-12
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 86 9.83e-26 0.654 1.55e-23
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 49 3.58e-15 0.650 1.54e-13
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 73 1.16e-21 -0.647 9.11e-20
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 89 3.20e-22 0.595 3.03e-20
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 107 7.80e-26 -0.588 1.55e-23
REACTOME TRANSLATION 124 6.94e-28 0.570 3.28e-25
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 83 5.12e-19 0.566 3.03e-17
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 2.02e-03 -0.538 3.54e-02
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 85 4.60e-17 0.527 2.42e-15
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 3.01e-03 0.517 4.91e-02
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 1.21e-07 -0.496 3.02e-06
REACTOME INFLUENZA LIFE CYCLE 115 1.01e-15 0.434 4.77e-14
REACTOME PYRUVATE METABOLISM 16 1.34e-02 -0.357 1.48e-01
REACTOME METABOLISM OF POLYAMINES 12 3.28e-02 0.356 2.59e-01
REACTOME MRNA SPLICING 99 1.59e-09 0.352 4.69e-08
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 13 3.22e-02 0.343 2.59e-01
REACTOME SHC MEDIATED SIGNALLING 13 3.50e-02 0.338 2.67e-01
REACTOME SHC RELATED EVENTS 14 3.10e-02 0.333 2.57e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 22 7.62e-03 0.329 1.16e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 8.02e-03 0.327 1.19e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT 42 2.83e-04 -0.324 5.58e-03
REACTOME HS GAG BIOSYNTHESIS 15 3.56e-02 -0.313 2.67e-01
REACTOME LAGGING STRAND SYNTHESIS 11 7.33e-02 0.312 3.65e-01
REACTOME MRNA SPLICING MINOR PATHWAY 39 8.12e-04 0.310 1.54e-02
REACTOME DNA STRAND ELONGATION 14 5.19e-02 0.300 3.19e-01
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 10 1.01e-01 -0.300 4.25e-01
REACTOME EXTENSION OF TELOMERES 16 4.04e-02 0.296 2.94e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 126 1.24e-08 0.295 3.26e-07
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 25 1.11e-02 -0.294 1.42e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 17 4.13e-02 -0.286 2.96e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 11 1.04e-01 0.283 4.30e-01
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 14 6.79e-02 -0.282 3.65e-01
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 8.26e-02 0.278 3.90e-01
REACTOME CELL JUNCTION ORGANIZATION 30 8.98e-03 -0.276 1.25e-01
REACTOME METABOLISM OF MRNA 179 2.48e-10 0.275 8.38e-09
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 13 8.58e-02 0.275 3.90e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 1.15e-01 0.274 4.40e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 12 9.99e-02 -0.274 4.25e-01
REACTOME MTORC1 MEDIATED SIGNALLING 11 1.17e-01 0.273 4.40e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 16 6.45e-02 -0.267 3.65e-01
REACTOME SULFUR AMINO ACID METABOLISM 19 4.40e-02 0.267 2.98e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 14 8.42e-02 0.267 3.90e-01
REACTOME HS GAG DEGRADATION 11 1.27e-01 -0.266 4.51e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 16 7.07e-02 0.261 3.65e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 3.07e-09 -0.785000 8.54e-08
REACTOME PEPTIDE CHAIN ELONGATION 67 1.43e-23 0.707000 1.69e-21
REACTOME RESPIRATORY ELECTRON TRANSPORT 59 3.97e-20 -0.691000 2.68e-18
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 4.00e-05 -0.685000 8.59e-04
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 2.58e-05 -0.674000 5.82e-04
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 42 4.49e-14 0.673000 1.77e-12
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 86 9.83e-26 0.654000 1.55e-23
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 49 3.58e-15 0.650000 1.54e-13
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 73 1.16e-21 -0.647000 9.11e-20
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 89 3.20e-22 0.595000 3.03e-20
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 107 7.80e-26 -0.588000 1.55e-23
REACTOME TRANSLATION 124 6.94e-28 0.570000 3.28e-25
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 83 5.12e-19 0.566000 3.03e-17
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 2.02e-03 -0.538000 3.54e-02
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 85 4.60e-17 0.527000 2.42e-15
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 3.01e-03 0.517000 4.91e-02
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 1.21e-07 -0.496000 3.02e-06
REACTOME INFLUENZA LIFE CYCLE 115 1.01e-15 0.434000 4.77e-14
REACTOME PYRUVATE METABOLISM 16 1.34e-02 -0.357000 1.48e-01
REACTOME METABOLISM OF POLYAMINES 12 3.28e-02 0.356000 2.59e-01
REACTOME MRNA SPLICING 99 1.59e-09 0.352000 4.69e-08
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 13 3.22e-02 0.343000 2.59e-01
REACTOME SHC MEDIATED SIGNALLING 13 3.50e-02 0.338000 2.67e-01
REACTOME SHC RELATED EVENTS 14 3.10e-02 0.333000 2.57e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 22 7.62e-03 0.329000 1.16e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 8.02e-03 0.327000 1.19e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT 42 2.83e-04 -0.324000 5.58e-03
REACTOME HS GAG BIOSYNTHESIS 15 3.56e-02 -0.313000 2.67e-01
REACTOME LAGGING STRAND SYNTHESIS 11 7.33e-02 0.312000 3.65e-01
REACTOME MRNA SPLICING MINOR PATHWAY 39 8.12e-04 0.310000 1.54e-02
REACTOME DNA STRAND ELONGATION 14 5.19e-02 0.300000 3.19e-01
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 10 1.01e-01 -0.300000 4.25e-01
REACTOME EXTENSION OF TELOMERES 16 4.04e-02 0.296000 2.94e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 126 1.24e-08 0.295000 3.26e-07
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 25 1.11e-02 -0.294000 1.42e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 17 4.13e-02 -0.286000 2.96e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 11 1.04e-01 0.283000 4.30e-01
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 14 6.79e-02 -0.282000 3.65e-01
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 8.26e-02 0.278000 3.90e-01
REACTOME CELL JUNCTION ORGANIZATION 30 8.98e-03 -0.276000 1.25e-01
REACTOME METABOLISM OF MRNA 179 2.48e-10 0.275000 8.38e-09
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 13 8.58e-02 0.275000 3.90e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 1.15e-01 0.274000 4.40e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 12 9.99e-02 -0.274000 4.25e-01
REACTOME MTORC1 MEDIATED SIGNALLING 11 1.17e-01 0.273000 4.40e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 16 6.45e-02 -0.267000 3.65e-01
REACTOME SULFUR AMINO ACID METABOLISM 19 4.40e-02 0.267000 2.98e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 14 8.42e-02 0.267000 3.90e-01
REACTOME HS GAG DEGRADATION 11 1.27e-01 -0.266000 4.51e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 16 7.07e-02 0.261000 3.65e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 12 1.18e-01 -0.261000 4.40e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 44 2.78e-03 -0.261000 4.70e-02
REACTOME MRNA 3 END PROCESSING 30 1.38e-02 0.260000 1.48e-01
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 20 4.58e-02 -0.258000 3.01e-01
REACTOME MRNA PROCESSING 140 1.67e-07 0.257000 3.95e-06
REACTOME PLATELET SENSITIZATION BY LDL 11 1.42e-01 -0.256000 4.86e-01
REACTOME MYOGENESIS 21 4.65e-02 -0.251000 3.01e-01
REACTOME METABOLISM OF RNA 219 3.66e-10 0.247000 1.16e-08
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 44 4.66e-03 0.247000 7.35e-02
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 14 1.18e-01 0.241000 4.40e-01
REACTOME IL RECEPTOR SHC SIGNALING 15 1.09e-01 0.239000 4.40e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 27 3.47e-02 -0.235000 2.67e-01
REACTOME MEMBRANE TRAFFICKING 94 1.01e-04 0.233000 2.08e-03
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 19 8.65e-02 0.227000 3.90e-01
REACTOME GLOBAL GENOMIC NER GG NER 25 4.94e-02 0.227000 3.11e-01
REACTOME LIPOPROTEIN METABOLISM 11 1.95e-01 -0.226000 5.70e-01
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 37 1.91e-02 0.223000 1.85e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 17 1.12e-01 0.223000 4.40e-01
REACTOME TIE2 SIGNALING 13 1.65e-01 -0.222000 5.21e-01
REACTOME GPCR LIGAND BINDING 46 9.54e-03 -0.221000 1.25e-01
REACTOME G2 M CHECKPOINTS 17 1.15e-01 0.221000 4.40e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 10 2.27e-01 -0.221000 6.09e-01
REACTOME METABOLISM OF PROTEINS 308 4.49e-11 0.220000 1.64e-09
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 36 2.31e-02 0.219000 2.10e-01
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 16 1.33e-01 0.217000 4.61e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 15 1.48e-01 0.216000 5.00e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 1.63e-01 0.216000 5.20e-01
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 22 8.29e-02 -0.214000 3.90e-01
REACTOME TELOMERE MAINTENANCE 20 1.02e-01 0.211000 4.28e-01
REACTOME CELL CELL JUNCTION ORGANIZATION 15 1.61e-01 -0.209000 5.19e-01
REACTOME SIGNALLING TO RAS 20 1.07e-01 0.208000 4.40e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 49 1.26e-02 0.206000 1.48e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 24 8.16e-02 0.205000 3.90e-01
REACTOME PURINE SALVAGE 10 2.63e-01 -0.205000 6.57e-01
REACTOME CELL CELL COMMUNICATION 54 9.49e-03 -0.204000 1.25e-01
REACTOME BASE EXCISION REPAIR 13 2.03e-01 0.204000 5.75e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 11 2.43e-01 0.204000 6.26e-01
REACTOME SEMAPHORIN INTERACTIONS 42 2.28e-02 -0.203000 2.10e-01
REACTOME PROTEIN FOLDING 40 2.79e-02 0.201000 2.44e-01
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 50 1.41e-02 0.201000 1.48e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 15 1.80e-01 0.200000 5.44e-01
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 54 1.30e-02 0.196000 1.48e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 25 9.26e-02 0.194000 4.09e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 13 2.33e-01 -0.191000 6.16e-01
REACTOME NETRIN1 SIGNALING 22 1.22e-01 -0.190000 4.46e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 16 1.91e-01 0.189000 5.63e-01
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY 10 3.06e-01 -0.187000 6.83e-01
REACTOME IL 2 SIGNALING 26 1.01e-01 0.186000 4.25e-01
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 18 1.75e-01 -0.185000 5.35e-01
REACTOME CTLA4 INHIBITORY SIGNALING 16 2.07e-01 -0.182000 5.75e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 24 1.24e-01 -0.182000 4.46e-01
REACTOME SIGNALING BY RHO GTPASES 65 1.30e-02 -0.178000 1.48e-01
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 17 2.05e-01 0.178000 5.75e-01
REACTOME INSULIN RECEPTOR RECYCLING 15 2.43e-01 0.174000 6.26e-01
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 10 3.43e-01 -0.173000 7.11e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 22 1.61e-01 0.173000 5.19e-01
REACTOME NUCLEAR SIGNALING BY ERBB4 21 1.72e-01 0.172000 5.27e-01
REACTOME DNA REPAIR 69 1.39e-02 0.172000 1.48e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS 13 2.97e-01 -0.167000 6.83e-01
REACTOME TRANSCRIPTION 126 1.31e-03 0.166000 2.39e-02
REACTOME TRNA AMINOACYLATION 39 7.27e-02 0.166000 3.65e-01
REACTOME ION CHANNEL TRANSPORT 18 2.22e-01 -0.166000 6.05e-01
REACTOME MEIOTIC SYNAPSIS 15 2.67e-01 0.166000 6.61e-01
REACTOME PHASE II CONJUGATION 24 1.68e-01 0.163000 5.25e-01
REACTOME REGULATION OF MITOTIC CELL CYCLE 61 2.96e-02 0.161000 2.50e-01
REACTOME CHROMOSOME MAINTENANCE 38 8.59e-02 0.161000 3.90e-01
REACTOME RNA POL I TRANSCRIPTION 26 1.57e-01 0.161000 5.12e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 43 6.91e-02 0.160000 3.65e-01
REACTOME PHOSPHORYLATION OF THE APC C 14 3.01e-01 0.160000 6.83e-01
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 21 2.08e-01 0.159000 5.75e-01
REACTOME RNA POL I TRANSCRIPTION TERMINATION 19 2.35e-01 0.158000 6.17e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 15 2.93e-01 -0.157000 6.83e-01
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING 20 2.25e-01 0.157000 6.08e-01
REACTOME NUCLEOTIDE EXCISION REPAIR 40 8.66e-02 0.157000 3.90e-01
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 19 2.42e-01 -0.155000 6.26e-01
REACTOME BASIGIN INTERACTIONS 13 3.34e-01 0.155000 7.04e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 21 2.20e-01 -0.155000 6.02e-01
REACTOME TCR SIGNALING 29 1.50e-01 -0.155000 5.00e-01
REACTOME IRON UPTAKE AND TRANSPORT 23 2.01e-01 0.154000 5.72e-01
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 11 3.78e-01 -0.154000 7.52e-01
REACTOME ER PHAGOSOME PATHWAY 49 6.50e-02 0.153000 3.65e-01
REACTOME SOS MEDIATED SIGNALLING 13 3.42e-01 0.152000 7.11e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 14 3.25e-01 0.152000 6.95e-01
REACTOME REGULATION OF APOPTOSIS 49 6.86e-02 0.151000 3.65e-01
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 44 8.47e-02 0.150000 3.90e-01
REACTOME CELL CYCLE CHECKPOINTS 78 2.23e-02 0.150000 2.10e-01
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA 13 3.50e-01 -0.150000 7.14e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 57 5.14e-02 0.149000 3.19e-01
REACTOME G ALPHA1213 SIGNALLING EVENTS 43 9.07e-02 -0.149000 4.05e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 16 3.02e-01 0.149000 6.83e-01
REACTOME MEIOSIS 25 1.98e-01 0.149000 5.70e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY 35 1.29e-01 -0.148000 4.51e-01
REACTOME SYNTHESIS OF DNA 63 4.22e-02 0.148000 2.98e-01
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 10 4.19e-01 -0.148000 7.80e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 18 2.81e-01 0.147000 6.74e-01
REACTOME REGULATION OF KIT SIGNALING 10 4.22e-01 0.147000 7.82e-01
REACTOME SIGNALING BY HIPPO 15 3.27e-01 -0.146000 6.97e-01
REACTOME RNA POL III CHAIN ELONGATION 16 3.12e-01 0.146000 6.83e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS 12 3.89e-01 -0.144000 7.58e-01
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 54 6.97e-02 0.143000 3.65e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI 14 3.57e-01 -0.142000 7.26e-01
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 41 1.17e-01 0.142000 4.40e-01
REACTOME SIGNALING BY BMP 17 3.17e-01 -0.140000 6.85e-01
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 56 7.24e-02 0.139000 3.65e-01
REACTOME RNA POL III TRANSCRIPTION 31 1.82e-01 0.139000 5.44e-01
REACTOME DOUBLE STRAND BREAK REPAIR 12 4.06e-01 0.139000 7.66e-01
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 43 1.16e-01 0.139000 4.40e-01
REACTOME NOD1 2 SIGNALING PATHWAY 19 2.96e-01 0.139000 6.83e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 21 2.72e-01 0.138000 6.67e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 18 3.09e-01 0.138000 6.83e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 11 4.27e-01 0.138000 7.86e-01
REACTOME FRS2 MEDIATED CASCADE 18 3.13e-01 0.138000 6.83e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 11 4.36e-01 -0.136000 7.88e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 44 1.21e-01 -0.135000 4.46e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 11 4.38e-01 0.135000 7.88e-01
REACTOME DEADENYLATION OF MRNA 16 3.50e-01 0.135000 7.14e-01
REACTOME P38MAPK EVENTS 10 4.61e-01 -0.135000 8.02e-01
REACTOME VIRAL MESSENGER RNA SYNTHESIS 14 3.83e-01 0.135000 7.53e-01
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 43 1.28e-01 0.134000 4.51e-01
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 130 9.03e-03 -0.133000 1.25e-01
REACTOME TRANSCRIPTION COUPLED NER TC NER 36 1.70e-01 0.132000 5.26e-01
REACTOME SIGNALING BY SCF KIT 58 8.21e-02 0.132000 3.90e-01
REACTOME G1 S TRANSITION 69 6.07e-02 0.131000 3.63e-01
REACTOME RNA POL II TRANSCRIPTION 85 3.76e-02 0.131000 2.78e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS 100 2.51e-02 0.130000 2.24e-01
REACTOME SIGNALING BY ERBB4 66 6.94e-02 0.130000 3.65e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM 50 1.14e-01 -0.129000 4.40e-01
REACTOME GPCR DOWNSTREAM SIGNALING 113 1.84e-02 -0.129000 1.85e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN 51 1.13e-01 0.128000 4.40e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION 19 3.35e-01 -0.128000 7.04e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 100 2.84e-02 0.127000 2.44e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS 15 3.95e-01 0.127000 7.58e-01
REACTOME RNA POL I TRANSCRIPTION INITIATION 23 2.93e-01 0.127000 6.83e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 57 1.01e-01 0.126000 4.25e-01
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX 10 4.92e-01 0.126000 8.18e-01
REACTOME MITOTIC G1 G1 S PHASES 84 4.83e-02 0.125000 3.09e-01
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 4.95e-01 -0.125000 8.18e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS 16 3.92e-01 -0.124000 7.58e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 11 4.79e-01 -0.123000 8.18e-01
REACTOME MEIOTIC RECOMBINATION 10 5.00e-01 0.123000 8.18e-01
REACTOME APOPTOTIC EXECUTION PHASE 28 2.62e-01 -0.123000 6.57e-01
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 82 5.60e-02 0.122000 3.40e-01
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 57 1.11e-01 0.122000 4.40e-01
REACTOME S PHASE 73 7.15e-02 0.122000 3.65e-01
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 22 3.22e-01 -0.122000 6.92e-01
REACTOME TRIF MEDIATED TLR3 SIGNALING 52 1.28e-01 0.122000 4.51e-01
REACTOME IL1 SIGNALING 24 3.01e-01 0.122000 6.83e-01
REACTOME MICRORNA MIRNA BIOGENESIS 18 3.72e-01 0.122000 7.50e-01
REACTOME SIGNAL ATTENUATION 10 5.06e-01 0.121000 8.18e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES 17 3.90e-01 -0.120000 7.58e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 30 2.56e-01 -0.120000 6.54e-01
REACTOME ELONGATION ARREST AND RECOVERY 24 3.10e-01 0.120000 6.83e-01
REACTOME PPARA ACTIVATES GENE EXPRESSION 81 6.37e-02 -0.119000 3.65e-01
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION 10 5.14e-01 -0.119000 8.21e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 18 3.83e-01 0.119000 7.53e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS 24 3.14e-01 0.119000 6.83e-01
REACTOME INTERFERON GAMMA SIGNALING 25 3.07e-01 0.118000 6.83e-01
REACTOME ERKS ARE INACTIVATED 10 5.20e-01 0.117000 8.26e-01
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 50 1.51e-01 0.117000 5.01e-01
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 22 3.44e-01 0.117000 7.11e-01
REACTOME POTASSIUM CHANNELS 23 3.40e-01 -0.115000 7.11e-01
REACTOME IL 3 5 AND GM CSF SIGNALING 26 3.11e-01 0.115000 6.83e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 53 1.50e-01 0.115000 5.00e-01
REACTOME ADP SIGNALLING THROUGH P2RY1 12 4.96e-01 -0.113000 8.18e-01
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 43 1.99e-01 0.113000 5.70e-01
REACTOME SIGNALING BY ILS 64 1.23e-01 0.112000 4.46e-01
REACTOME SMOOTH MUSCLE CONTRACTION 18 4.12e-01 0.112000 7.71e-01
REACTOME G ALPHA S SIGNALLING EVENTS 32 2.76e-01 -0.111000 6.72e-01
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 46 1.96e-01 0.110000 5.70e-01
REACTOME SIGNAL AMPLIFICATION 16 4.46e-01 -0.110000 7.96e-01
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 44 2.07e-01 0.110000 5.75e-01
REACTOME PKB MEDIATED EVENTS 28 3.15e-01 0.110000 6.83e-01
REACTOME INTERFERON ALPHA BETA SIGNALING 17 4.34e-01 -0.110000 7.88e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 41 2.28e-01 0.109000 6.10e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 17 4.38e-01 -0.109000 7.88e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 12 5.23e-01 0.106000 8.28e-01
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 14 4.91e-01 -0.106000 8.18e-01
REACTOME DARPP 32 EVENTS 19 4.25e-01 0.106000 7.85e-01
REACTOME M G1 TRANSITION 53 1.86e-01 0.105000 5.54e-01
REACTOME AXON GUIDANCE 145 3.25e-02 -0.103000 2.59e-01
REACTOME GLYCOLYSIS 19 4.38e-01 0.103000 7.88e-01
REACTOME NCAM1 INTERACTIONS 17 4.64e-01 -0.103000 8.02e-01
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 18 4.55e-01 -0.102000 8.02e-01
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 50 2.14e-01 0.102000 5.89e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 23 4.06e-01 -0.100000 7.66e-01
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 16 4.89e-01 0.099900 8.18e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM 10 5.88e-01 0.099000 8.66e-01
REACTOME INNATE IMMUNE SYSTEM 120 6.23e-02 0.098900 3.65e-01
REACTOME CELL CYCLE 218 1.27e-02 0.098600 1.48e-01
REACTOME BOTULINUM NEUROTOXICITY 10 5.90e-01 -0.098500 8.66e-01
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS 10 5.90e-01 -0.098500 8.66e-01
REACTOME CELL CYCLE MITOTIC 193 1.92e-02 0.098300 1.85e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 48 2.43e-01 -0.097600 6.26e-01
REACTOME GLUCAGON TYPE LIGAND RECEPTORS 10 5.94e-01 0.097500 8.67e-01
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN 18 4.75e-01 -0.097400 8.13e-01
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 51 2.31e-01 0.097000 6.15e-01
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 47 2.61e-01 0.094900 6.57e-01
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 33 3.47e-01 -0.094800 7.13e-01
REACTOME RNA POL III TRANSCRIPTION TERMINATION 18 4.89e-01 0.094200 8.18e-01
REACTOME COMPLEMENT CASCADE 11 5.89e-01 0.094100 8.66e-01
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT 19 4.81e-01 0.093400 8.18e-01
REACTOME SIGNALING BY GPCR 157 4.48e-02 -0.093200 2.98e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 17 5.09e-01 -0.092700 8.18e-01
REACTOME HIV INFECTION 160 4.47e-02 0.092400 2.98e-01
REACTOME METABOLISM OF NON CODING RNA 43 2.97e-01 0.092100 6.83e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 11 5.97e-01 -0.092100 8.67e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 28 4.00e-01 0.092000 7.63e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 109 9.96e-02 0.091600 4.25e-01
REACTOME PURINE METABOLISM 27 4.11e-01 0.091400 7.71e-01
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA 18 5.02e-01 -0.091400 8.18e-01
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 47 2.79e-01 0.091300 6.74e-01
REACTOME SIGNALING BY NOTCH3 10 6.22e-01 -0.090000 8.74e-01
REACTOME GLUTATHIONE CONJUGATION 12 5.93e-01 0.089200 8.67e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 11 6.13e-01 -0.088000 8.74e-01
REACTOME G0 AND EARLY G1 11 6.15e-01 0.087600 8.74e-01
REACTOME SYNTHESIS OF PC 10 6.32e-01 0.087400 8.80e-01
REACTOME PEROXISOMAL LIPID METABOLISM 16 5.47e-01 -0.087000 8.57e-01
REACTOME DOWNSTREAM TCR SIGNALING 20 5.08e-01 -0.085700 8.18e-01
REACTOME HIV LIFE CYCLE 96 1.48e-01 0.085600 5.00e-01
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 55 2.77e-01 0.084900 6.72e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS 16 5.58e-01 -0.084700 8.65e-01
REACTOME NEURONAL SYSTEM 92 1.64e-01 -0.084100 5.21e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 26 4.60e-01 0.083800 8.02e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 14 5.88e-01 0.083600 8.66e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS 16 5.63e-01 -0.083600 8.66e-01
REACTOME LATE PHASE OF HIV LIFE CYCLE 87 1.81e-01 0.083300 5.44e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS 37 3.84e-01 0.082800 7.53e-01
REACTOME PYRIMIDINE METABOLISM 10 6.53e-01 -0.082200 8.87e-01
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 286 1.79e-02 -0.082100 1.84e-01
REACTOME METABOLISM OF PORPHYRINS 11 6.38e-01 0.082000 8.80e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 53 3.06e-01 -0.081500 6.83e-01
REACTOME INSULIN SYNTHESIS AND PROCESSING 13 6.12e-01 0.081300 8.74e-01
REACTOME SYNTHESIS OF PA 12 6.26e-01 0.081200 8.76e-01
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 56 2.97e-01 0.080700 6.83e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 13 6.15e-01 0.080600 8.74e-01
REACTOME ENOS ACTIVATION AND REGULATION 12 6.32e-01 -0.080000 8.80e-01
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 17 5.75e-01 0.078600 8.66e-01
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 16 5.88e-01 0.078300 8.66e-01
REACTOME DNA REPLICATION 111 1.56e-01 0.078100 5.12e-01
REACTOME NEPHRIN INTERACTIONS 15 6.03e-01 -0.077500 8.73e-01
REACTOME SIGNALING BY ERBB2 70 2.67e-01 0.076900 6.61e-01
REACTOME BIOLOGICAL OXIDATIONS 39 4.07e-01 0.076900 7.66e-01
REACTOME G ALPHA Q SIGNALLING EVENTS 45 3.74e-01 -0.076600 7.50e-01
REACTOME ACTIVATED TLR4 SIGNALLING 59 3.14e-01 0.076000 6.83e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 191 7.29e-02 0.075700 3.65e-01
REACTOME SIGNALING BY INSULIN RECEPTOR 75 2.61e-01 0.075300 6.57e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 11 6.66e-01 0.075200 9.00e-01
REACTOME DEVELOPMENTAL BIOLOGY 244 4.45e-02 -0.075200 2.98e-01
REACTOME SIGNALING BY NOTCH2 10 6.81e-01 -0.075100 9.05e-01
REACTOME SIGNALING BY ROBO RECEPTOR 20 5.64e-01 -0.074600 8.66e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 64 3.09e-01 0.073700 6.83e-01
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 37 4.41e-01 0.073300 7.90e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 36 4.47e-01 0.073200 7.96e-01
REACTOME SIGNALING BY FGFR MUTANTS 27 5.11e-01 -0.073200 8.19e-01
REACTOME G1 PHASE 25 5.30e-01 0.072700 8.35e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 39 4.34e-01 -0.072600 7.88e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 16 6.19e-01 -0.071900 8.74e-01
REACTOME HEMOSTASIS 230 6.78e-02 -0.070400 3.65e-01
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 49 3.96e-01 0.070200 7.58e-01
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 17 6.17e-01 -0.070100 8.74e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 32 4.93e-01 -0.070100 8.18e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 53 3.79e-01 0.070000 7.52e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 17 6.21e-01 0.069300 8.74e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 22 5.80e-01 -0.068100 8.66e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 11 6.96e-01 0.068100 9.08e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 39 4.64e-01 0.067800 8.02e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 166 1.34e-01 0.067800 4.61e-01
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 13 6.80e-01 0.066100 9.05e-01
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 41 4.65e-01 0.066100 8.02e-01
REACTOME LYSOSOME VESICLE BIOGENESIS 17 6.45e-01 0.064700 8.84e-01
REACTOME MITOTIC M M G1 PHASES 99 2.68e-01 0.064600 6.61e-01
REACTOME GLUCOSE METABOLISM 46 4.50e-01 0.064500 7.96e-01
REACTOME COLLAGEN FORMATION 28 5.56e-01 -0.064400 8.65e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 17 6.46e-01 -0.064300 8.84e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 67 3.73e-01 -0.063100 7.50e-01
REACTOME PLATELET HOMEOSTASIS 35 5.20e-01 -0.062900 8.26e-01
REACTOME PIP3 ACTIVATES AKT SIGNALING 25 5.87e-01 0.062900 8.66e-01
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 17 6.55e-01 0.062700 8.87e-01
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 17 6.55e-01 0.062700 8.87e-01
REACTOME ARMS MEDIATED ACTIVATION 14 6.86e-01 -0.062400 9.05e-01
REACTOME RAP1 SIGNALLING 12 7.11e-01 -0.061700 9.09e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 10 7.37e-01 0.061400 9.24e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 149 1.98e-01 0.061400 5.70e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 29 5.70e-01 0.061000 8.66e-01
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 15 6.83e-01 -0.060900 9.05e-01
REACTOME GLUCOSE TRANSPORT 31 5.73e-01 0.058500 8.66e-01
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 15 7.03e-01 -0.056800 9.08e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING 13 7.28e-01 -0.055800 9.23e-01
REACTOME DAG AND IP3 SIGNALING 18 6.85e-01 0.055300 9.05e-01
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 25 6.37e-01 -0.054500 8.80e-01
REACTOME INTERFERON SIGNALING 83 3.94e-01 0.054200 7.58e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 32 5.98e-01 0.054000 8.67e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 61 4.67e-01 0.053900 8.04e-01
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 18 6.92e-01 0.053900 9.07e-01
REACTOME INWARDLY RECTIFYING K CHANNELS 11 7.58e-01 -0.053700 9.27e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 13 7.39e-01 0.053500 9.24e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 116 3.29e-01 -0.052700 6.98e-01
REACTOME SIGNALING BY WNT 57 5.01e-01 0.051600 8.18e-01
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 17 7.15e-01 -0.051200 9.12e-01
REACTOME REGULATORY RNA PATHWAYS 21 6.89e-01 0.050500 9.05e-01
REACTOME SIGNALING BY FGFR 73 4.59e-01 0.050300 8.02e-01
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 16 7.31e-01 0.049600 9.24e-01
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 18 7.22e-01 -0.048500 9.17e-01
REACTOME SPHINGOLIPID METABOLISM 37 6.15e-01 -0.047800 8.74e-01
REACTOME MUSCLE CONTRACTION 36 6.21e-01 0.047600 8.74e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 73 4.83e-01 0.047600 8.18e-01
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 53 5.52e-01 -0.047300 8.61e-01
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS 25 6.87e-01 0.046500 9.05e-01
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 18 7.35e-01 -0.046100 9.24e-01
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 12 7.84e-01 0.045700 9.38e-01
REACTOME PLC BETA MEDIATED EVENTS 23 7.09e-01 -0.045000 9.09e-01
REACTOME PLATELET CALCIUM HOMEOSTASIS 10 8.06e-01 -0.044900 9.43e-01
REACTOME RECYCLING PATHWAY OF L1 19 7.35e-01 0.044900 9.24e-01
REACTOME SIGNALING BY EGFR IN CANCER 85 4.85e-01 0.043900 8.18e-01
REACTOME SIGNALLING TO ERKS 28 7.00e-01 0.042200 9.08e-01
REACTOME SIGNALING BY FGFR IN DISEASE 85 5.05e-01 0.042000 8.18e-01
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 19 7.54e-01 0.041500 9.27e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 44 6.35e-01 0.041500 8.80e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 32 6.86e-01 -0.041300 9.05e-01
REACTOME SIGNALING BY NODAL 11 8.21e-01 0.039300 9.43e-01
REACTOME GABA B RECEPTOR ACTIVATION 16 7.86e-01 0.039200 9.38e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM 15 7.93e-01 0.039200 9.42e-01
REACTOME DESTABILIZATION OF MRNA BY BRF1 16 7.87e-01 0.039000 9.38e-01
REACTOME TOLL RECEPTOR CASCADES 72 5.71e-01 0.038700 8.66e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 22 7.56e-01 -0.038300 9.27e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 21 7.66e-01 -0.037500 9.27e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 24 7.52e-01 -0.037200 9.27e-01
REACTOME GLUCONEOGENESIS 21 7.69e-01 -0.037100 9.27e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS 12 8.26e-01 -0.036700 9.43e-01
REACTOME CD28 CO STIMULATION 23 7.61e-01 -0.036600 9.27e-01
REACTOME SIGNALING BY NOTCH 77 5.80e-01 -0.036500 8.66e-01
REACTOME IMMUNE SYSTEM 522 1.70e-01 0.035700 5.26e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 100 5.43e-01 0.035300 8.53e-01
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 25 7.60e-01 0.035300 9.27e-01
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 11 8.40e-01 0.035100 9.51e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT 24 7.69e-01 0.034700 9.27e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 11 8.44e-01 -0.034200 9.51e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 15 8.19e-01 0.034100 9.43e-01
REACTOME UNFOLDED PROTEIN RESPONSE 64 6.42e-01 -0.033700 8.83e-01
REACTOME REGULATION OF SIGNALING BY CBL 15 8.22e-01 -0.033600 9.43e-01
REACTOME SIGNALING BY NOTCH4 10 8.54e-01 -0.033600 9.54e-01
REACTOME CIRCADIAN CLOCK 43 7.05e-01 0.033400 9.08e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 29 7.56e-01 0.033300 9.27e-01
REACTOME METABOLISM OF NUCLEOTIDES 48 6.97e-01 0.032500 9.08e-01
REACTOME OPIOID SIGNALLING 44 7.11e-01 0.032400 9.09e-01
REACTOME STRIATED MUSCLE CONTRACTION 22 7.97e-01 -0.031800 9.42e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 105 5.79e-01 0.031400 8.66e-01
REACTOME PI METABOLISM 38 7.41e-01 0.031100 9.24e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 65 6.69e-01 0.030700 9.01e-01
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 21 8.08e-01 -0.030700 9.43e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 34 7.69e-01 0.029200 9.27e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 21 8.18e-01 0.029000 9.43e-01
REACTOME REGULATION OF INSULIN SECRETION 43 7.59e-01 0.027100 9.27e-01
REACTOME SIGNAL TRANSDUCTION BY L1 28 8.06e-01 0.026900 9.43e-01
REACTOME CALNEXIN CALRETICULIN CYCLE 11 8.79e-01 0.026500 9.65e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 18 8.49e-01 0.025900 9.52e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 73 7.03e-01 0.025800 9.08e-01
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 11 8.87e-01 0.024700 9.66e-01
REACTOME G PROTEIN ACTIVATION 12 8.85e-01 -0.024100 9.66e-01
REACTOME CA DEPENDENT EVENTS 15 8.73e-01 0.023800 9.63e-01
REACTOME G ALPHA I SIGNALLING EVENTS 32 8.21e-01 0.023100 9.43e-01
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 24 8.49e-01 -0.022500 9.52e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 45 7.96e-01 0.022300 9.42e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 59 7.70e-01 0.022000 9.27e-01
REACTOME EGFR DOWNREGULATION 23 8.55e-01 -0.022000 9.54e-01
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 35 8.25e-01 0.021600 9.43e-01
REACTOME INTEGRATION OF ENERGY METABOLISM 66 7.63e-01 0.021500 9.27e-01
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 39 8.24e-01 0.020600 9.43e-01
REACTOME GLYCOSPHINGOLIPID METABOLISM 21 8.71e-01 -0.020400 9.63e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 24 8.63e-01 0.020400 9.58e-01
REACTOME PERK REGULATED GENE EXPRESSION 22 8.73e-01 -0.019700 9.63e-01
REACTOME SIGNALLING BY NGF 157 6.83e-01 0.019000 9.05e-01
REACTOME MITOTIC G2 G2 M PHASES 50 8.20e-01 -0.018700 9.43e-01
REACTOME GABA RECEPTOR ACTIVATION 17 8.94e-01 -0.018600 9.68e-01
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 21 8.83e-01 0.018600 9.66e-01
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS 11 9.17e-01 -0.018300 9.69e-01
REACTOME MITOTIC PROMETAPHASE 45 8.35e-01 0.018000 9.49e-01
REACTOME ADAPTIVE IMMUNE SYSTEM 345 5.86e-01 0.017200 8.66e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 63 8.14e-01 -0.017200 9.43e-01
REACTOME G ALPHA Z SIGNALLING EVENTS 23 8.88e-01 0.017000 9.66e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE 18 9.08e-01 -0.015800 9.69e-01
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 11 9.28e-01 -0.015700 9.69e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 12 9.25e-01 -0.015700 9.69e-01
REACTOME PI3K CASCADE 47 8.57e-01 0.015200 9.54e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION 61 8.45e-01 -0.014500 9.51e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 9.13e-01 0.014200 9.69e-01
REACTOME METABOLISM OF CARBOHYDRATES 136 7.78e-01 -0.014000 9.34e-01
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 23 9.07e-01 0.014000 9.69e-01
REACTOME GAB1 SIGNALOSOME 32 8.91e-01 0.014000 9.67e-01
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 104 8.08e-01 0.013800 9.43e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 23 9.13e-01 0.013200 9.69e-01
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 30 9.01e-01 0.013100 9.69e-01
REACTOME CHOLESTEROL BIOSYNTHESIS 13 9.35e-01 0.013100 9.69e-01
REACTOME APOPTOSIS 97 8.27e-01 0.012900 9.43e-01
REACTOME SIGNALING BY PDGF 90 8.40e-01 -0.012300 9.51e-01
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 19 9.26e-01 0.012300 9.69e-01
REACTOME ERK MAPK TARGETS 18 9.31e-01 -0.011700 9.69e-01
REACTOME MRNA CAPPING 28 9.16e-01 -0.011500 9.69e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 36 9.05e-01 -0.011500 9.69e-01
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX 27 9.19e-01 0.011400 9.69e-01
REACTOME ACTIVATION OF GENES BY ATF4 19 9.34e-01 -0.011100 9.69e-01
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 37 9.09e-01 -0.010900 9.69e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 13 9.47e-01 -0.010600 9.76e-01
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS 16 9.43e-01 0.010300 9.74e-01
REACTOME SIGNALING BY FGFR1 MUTANTS 20 9.38e-01 -0.009990 9.71e-01
REACTOME PI 3K CASCADE 35 9.26e-01 0.009130 9.69e-01
REACTOME SHC MEDIATED CASCADE 11 9.60e-01 0.008670 9.83e-01
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 12 9.62e-01 -0.007920 9.83e-01
REACTOME SIGNALING BY NOTCH1 53 9.22e-01 -0.007780 9.69e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS 12 9.66e-01 -0.007120 9.85e-01
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 180 8.75e-01 0.006810 9.63e-01
REACTOME DIABETES PATHWAYS 92 9.15e-01 -0.006490 9.69e-01
REACTOME METAL ION SLC TRANSPORTERS 12 9.71e-01 0.006050 9.86e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 13 9.71e-01 0.005800 9.86e-01
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 62 9.54e-01 0.004280 9.81e-01
REACTOME L1CAM INTERACTIONS 51 9.59e-01 -0.004120 9.83e-01
REACTOME ADP SIGNALLING THROUGH P2RY12 11 9.84e-01 0.003550 9.92e-01
REACTOME PI3K AKT ACTIVATION 31 9.78e-01 -0.002910 9.89e-01
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX 28 9.79e-01 -0.002900 9.89e-01
REACTOME SPRY REGULATION OF FGF SIGNALING 12 9.90e-01 0.002190 9.94e-01
REACTOME PHOSPHOLIPID METABOLISM 119 9.88e-01 -0.000823 9.94e-01
REACTOME DESTABILIZATION OF MRNA BY KSRP 14 9.99e-01 -0.000238 9.99e-01
REACTOME GENERIC TRANSCRIPTION PATHWAY 141 9.97e-01 -0.000214 9.99e-01


Detailed Gene set reports



REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE

REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
225
set REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE
setSize 19
pANOVA 3.07e-09
s.dist -0.785
p.adjustANOVA 8.54e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Idh2 -4590
Sdhb -4560
Nnt -4443
Mdh2 -4214
Suclg1 -4032
Sdha -3965
Sdhd -3918
Fh1 -3862
Sdhc -3753
Idh3g -3703
Sucla2 -3692
Idh3b -3556
Ogdh -3551
Cs -3543
Suclg2 -3467
Idh3a -3394
Dlst -3299
Dld -3079
Aco2 -1735

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Idh2 -4590
Sdhb -4560
Nnt -4443
Mdh2 -4214
Suclg1 -4032
Sdha -3965
Sdhd -3918
Fh1 -3862
Sdhc -3753
Idh3g -3703
Sucla2 -3692
Idh3b -3556
Ogdh -3551
Cs -3543
Suclg2 -3467
Idh3a -3394
Dlst -3299
Dld -3079
Aco2 -1735


REACTOME_PEPTIDE_CHAIN_ELONGATION

REACTOME_PEPTIDE_CHAIN_ELONGATION
168
set REACTOME_PEPTIDE_CHAIN_ELONGATION
setSize 67
pANOVA 1.43e-23
s.dist 0.707
p.adjustANOVA 1.69e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Eef2 4675
Rpl6 4629
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpl10a 4430
Rpsa 4416
Rps23 4404
Rpl13 4321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Eef2 4675.0
Rpl6 4629.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Rps3 4450.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Rps23 4404.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpl26 4052.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Rps6 3917.0
Rpl18 3853.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Rpl27a 3724.0
Rps18 3646.0
Eef1a1 3621.0
Rps26 3580.0
Rpl23 3499.0
Rpl28 3412.0
Rpl41 3393.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Rpl30 2992.0
Rps8 2985.0
Rpl5 2573.0
Rps27a 2556.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Rps11 1720.0
Rpl29 1671.0
Rpl37a 1603.0
Uba52 1341.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Rpl39 640.0
Rpl27-ps3 602.5
Rps12-ps3 409.0
Rpl3l -1613.0


REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
337
set REACTOME_RESPIRATORY_ELECTRON_TRANSPORT
setSize 59
pANOVA 3.97e-20
s.dist -0.691
p.adjustANOVA 2.68e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ndufb3 -4572
Ndufv1 -4565
Sdhb -4560
Uqcrq -4516
Uqcrc1 -4383
Ndufa11 -4369
Cycs -4366
Ndufs1 -4358
Ndufs6 -4302
Cox6c -4260
Ndufs4 -4207
Cyc1 -4206
Uqcrfs1 -4202
Etfb -4167
Etfa -4150
Ndufa9 -4134
Etfdh -4131
Cox4i1 -4072
Ndufb5 -4057
Ndufa5 -4041

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufb3 -4572
Ndufv1 -4565
Sdhb -4560
Uqcrq -4516
Uqcrc1 -4383
Ndufa11 -4369
Cycs -4366
Ndufs1 -4358
Ndufs6 -4302
Cox6c -4260
Ndufs4 -4207
Cyc1 -4206
Uqcrfs1 -4202
Etfb -4167
Etfa -4150
Ndufa9 -4134
Etfdh -4131
Cox4i1 -4072
Ndufb5 -4057
Ndufa5 -4041
Cox6b1 -4025
Uqcrc2 -3991
Ndufb7 -3979
Cox7c -3975
Sdha -3965
Sdhd -3918
Ndufb10 -3905
Ndufb6 -3844
Ndufs8 -3800
Sdhc -3753
Uqcrb -3746
Ndufab1 -3635
Ndufa3 -3619
Ndufa6 -3541
Ndufb9 -3506
Ndufb2 -3470
Ndufa4 -3465
Ndufc1 -3459
Ndufb4 -3454
Ndufa8 -3333
Ndufa2 -3252
Uqcrh -3215
Cox5a -3190
Ndufs5 -3015
Ndufv2 -2930
Ndufa1 -2898
Ndufa10 -2845
Cox7a2l -2784
Ndufs7 -2469
Uqcr11 -2331
Ndufa13 -2071
Ndufs3 -1785
Ndufs2 -1712
Ndufc2 -1509
Ndufa7 -905
Ndufv3 37
Ndufa12 106
Cox8a 2301
Cox6a1 3381


REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING

REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
416
set REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING
setSize 12
pANOVA 4e-05
s.dist -0.685
p.adjustANOVA 0.000859



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5g1 -4332
Atp5j2 -4253
Atp5j -3812
Atp5l -3633
Atp5k -3609
Atp5a1 -3555
Atp5b -3457
Atp5c1 -3382
Atp5o -2983
Atp5h -1988
Atp5e -1869
Atp5d -1811

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5g1 -4332
Atp5j2 -4253
Atp5j -3812
Atp5l -3633
Atp5k -3609
Atp5a1 -3555
Atp5b -3457
Atp5c1 -3382
Atp5o -2983
Atp5h -1988
Atp5e -1869
Atp5d -1811


REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
170
set REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize 13
pANOVA 2.58e-05
s.dist -0.674
p.adjustANOVA 0.000582



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eci1 -4616
Acadvl -4563
Hadhb -4541
Acadm -4529
Decr1 -4414
Hadh -4351
Acadl -3997
Acads -3921
Hadha -3833
Pcca -2959
Mcee -2100
Echs1 -69
Pccb 2668

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eci1 -4616
Acadvl -4563
Hadhb -4541
Acadm -4529
Decr1 -4414
Hadh -4351
Acadl -3997
Acads -3921
Hadha -3833
Pcca -2959
Mcee -2100
Echs1 -69
Pccb 2668


REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
9
set REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
setSize 42
pANOVA 4.49e-14
s.dist 0.673
p.adjustANOVA 1.77e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps3a1 4686
Eif2s3x 4615
Rps4x 4589
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpsa 4416
Rps23 4404
Eif3e 4402
Rps5 4318
Rps24 4294
Rps16 4280
Rps27 4182
Rps21 4146
Rps20 4006
Rps14 3999
Eif3i 3961
Rps6 3917
Rps7 3747

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps3a1 4686
Eif2s3x 4615
Rps4x 4589
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpsa 4416
Rps23 4404
Eif3e 4402
Rps5 4318
Rps24 4294
Rps16 4280
Rps27 4182
Rps21 4146
Rps20 4006
Rps14 3999
Eif3i 3961
Rps6 3917
Rps7 3747
Eif3c 3725
Eif3a 3701
Rps18 3646
Rps26 3580
Eif3g 3568
Eif3b 3490
Eif3d 3444
Rps15a 3213
Rps13 3137
Rps8 2985
Eif3j2 2604
Eif2s2 2592
Rps27a 2556
Rps17 2408
Rps29 2366
Eif3f 2135
Eif3k 2110
Rps11 1720
Eif3h 855
Rps12-ps3 409
Eif1ax -848
Eif2s1 -1528


REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION

REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
221
set REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION
setSize 86
pANOVA 9.83e-26
s.dist 0.654
p.adjustANOVA 1.55e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif4b 4821
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Rpl6 4629
Eif2s3x 4615
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpl10a 4430
Rpsa 4416
Rps23 4404

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif4b 4821.0
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Rpl6 4629.0
Eif2s3x 4615.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Rps3 4450.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Rps23 4404.0
Eif3e 4402.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpl26 4052.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Eif3i 3961.0
Rps6 3917.0
Rpl18 3853.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Eif3c 3725.0
Rpl27a 3724.0
Eif3a 3701.0
Eif4h 3700.0
Rps18 3646.0
Rps26 3580.0
Eif3g 3568.0
Rpl23 3499.0
Eif3b 3490.0
Eif3d 3444.0
Rpl28 3412.0
Rpl41 3393.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Rpl30 2992.0
Rps8 2985.0
Eif3j2 2604.0
Eif4a2 2603.0
Eif2s2 2592.0
Rpl5 2573.0
Rps27a 2556.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Eif3f 2135.0
Eif3k 2110.0
Rps11 1720.0
Rpl29 1671.0
Rpl37a 1603.0
Eif4a1 1575.0
Eif4g1 1343.0
Uba52 1341.0
Eif3h 855.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Rpl39 640.0
Rpl27-ps3 602.5
Rps12-ps3 409.0
Eif1ax -848.0
Eif4e -1413.0
Eif2s1 -1528.0
Rpl3l -1613.0


REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S

REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S
144
set REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S
setSize 49
pANOVA 3.58e-15
s.dist 0.65
p.adjustANOVA 1.54e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif4b 4821
Eif4ebp1 4794
Rps3a1 4686
Eif2s3x 4615
Rps4x 4589
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpsa 4416
Rps23 4404
Eif3e 4402
Rps5 4318
Rps24 4294
Rps16 4280
Rps27 4182
Rps21 4146
Rps20 4006
Rps14 3999
Eif3i 3961

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif4b 4821
Eif4ebp1 4794
Rps3a1 4686
Eif2s3x 4615
Rps4x 4589
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpsa 4416
Rps23 4404
Eif3e 4402
Rps5 4318
Rps24 4294
Rps16 4280
Rps27 4182
Rps21 4146
Rps20 4006
Rps14 3999
Eif3i 3961
Rps6 3917
Rps7 3747
Eif3c 3725
Eif3a 3701
Eif4h 3700
Rps18 3646
Rps26 3580
Eif3g 3568
Eif3b 3490
Eif3d 3444
Rps15a 3213
Rps13 3137
Rps8 2985
Eif3j2 2604
Eif4a2 2603
Eif2s2 2592
Rps27a 2556
Rps17 2408
Rps29 2366
Eif3f 2135
Eif3k 2110
Rps11 1720
Eif4a1 1575
Eif4g1 1343
Eif3h 855
Rps12-ps3 409
Eif1ax -848
Eif4e -1413
Eif2s1 -1528


REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
410
set REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_
setSize 73
pANOVA 1.16e-21
s.dist -0.647
p.adjustANOVA 9.11e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ndufb3 -4572
Ndufv1 -4565
Sdhb -4560
Uqcrq -4516
Uqcrc1 -4383
Ndufa11 -4369
Cycs -4366
Ndufs1 -4358
Atp5g1 -4332
Ndufs6 -4302
Cox6c -4260
Atp5j2 -4253
Ndufs4 -4207
Cyc1 -4206
Uqcrfs1 -4202
Etfb -4167
Etfa -4150
Ndufa9 -4134
Etfdh -4131
Cox4i1 -4072

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufb3 -4572
Ndufv1 -4565
Sdhb -4560
Uqcrq -4516
Uqcrc1 -4383
Ndufa11 -4369
Cycs -4366
Ndufs1 -4358
Atp5g1 -4332
Ndufs6 -4302
Cox6c -4260
Atp5j2 -4253
Ndufs4 -4207
Cyc1 -4206
Uqcrfs1 -4202
Etfb -4167
Etfa -4150
Ndufa9 -4134
Etfdh -4131
Cox4i1 -4072
Ndufb5 -4057
Ndufa5 -4041
Cox6b1 -4025
Uqcrc2 -3991
Ndufb7 -3979
Cox7c -3975
Sdha -3965
Sdhd -3918
Ndufb10 -3905
Ndufb6 -3844
Atp5j -3812
Ndufs8 -3800
Sdhc -3753
Uqcrb -3746
Ndufab1 -3635
Atp5l -3633
Ndufa3 -3619
Atp5k -3609
Atp5a1 -3555
Ndufa6 -3541
Ndufb9 -3506
Ndufb2 -3470
Ndufa4 -3465
Ndufc1 -3459
Atp5b -3457
Ndufb4 -3454
Atp5c1 -3382
Ndufa8 -3333
Ndufa2 -3252
Uqcrh -3215
Cox5a -3190
Ndufs5 -3015
Atp5o -2983
Ndufv2 -2930
Ndufa1 -2898
Ndufa10 -2845
Cox7a2l -2784
Ndufs7 -2469
Uqcr11 -2331
Ndufa13 -2071
Atp5h -1988
Atp5e -1869
Atp5d -1811
Ndufs3 -1785
Ndufs2 -1712
Ndufc2 -1509
Ndufa7 -905
Ndufv3 37
Ndufa12 106
Cox8a 2301
Cox6a1 3381
Ucp2 4352
Ucp3 4729


REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE

REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
57
set REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE
setSize 89
pANOVA 3.2e-22
s.dist 0.595
p.adjustANOVA 3.03e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Rpl6 4629
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Srp72 4488
Rps3 4450
Ssr4 4448
Rps19 4436
Rpl10a 4430
Rpsa 4416
Rps23 4404

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Rpl6 4629.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Srp72 4488.0
Rps3 4450.0
Ssr4 4448.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Rps23 4404.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpn2 4122.0
Spcs2 4087.0
Rpl26 4052.0
Sec11c 4049.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Rps6 3917.0
Rpl18 3853.0
Rpn1 3821.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Rpl27a 3724.0
Rps18 3646.0
Rps26 3580.0
Rpl23 3499.0
Rpl28 3412.0
Rpl41 3393.0
Ssr1 3277.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Rpl30 2992.0
Rps8 2985.0
Rpl5 2573.0
Rps27a 2556.0
Ssr2 2545.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Ssr3 2094.0
Srp68 1849.0
Rps11 1720.0
Rpl29 1671.0
Rpl37a 1603.0
Sec61b 1573.0
Spcs1 1558.0
Uba52 1341.0
Ddost 1077.0
Sec11a 1007.0
Srp54a 876.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Rpl39 640.0
Sec61g 631.0
Spcs3 618.0
Rpl27-ps3 602.5
Sec61a2 600.0
Rps12-ps3 409.0
Srp14 -77.0
Srprb -298.0
Srp9 -529.0
Rpl3l -1613.0
Srp19 -1646.0
Sec61a1 -1805.0
Tram1 -2648.0


REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
25
set REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT
setSize 107
pANOVA 7.8e-26
s.dist -0.588
p.adjustANOVA 1.55e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Idh2 -4590
Ndufb3 -4572
Ndufv1 -4565
Sdhb -4560
Ldhb -4534
Uqcrq -4516
L2hgdh -4480
Nnt -4443
Uqcrc1 -4383
Ndufa11 -4369
Cycs -4366
Ndufs1 -4358
Atp5g1 -4332
Ndufs6 -4302
Cox6c -4260
Atp5j2 -4253
Mdh2 -4214
Ndufs4 -4207

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Idh2 -4590
Ndufb3 -4572
Ndufv1 -4565
Sdhb -4560
Ldhb -4534
Uqcrq -4516
L2hgdh -4480
Nnt -4443
Uqcrc1 -4383
Ndufa11 -4369
Cycs -4366
Ndufs1 -4358
Atp5g1 -4332
Ndufs6 -4302
Cox6c -4260
Atp5j2 -4253
Mdh2 -4214
Ndufs4 -4207
Cyc1 -4206
Uqcrfs1 -4202
Etfb -4167
Etfa -4150
Ndufa9 -4134
Pdpr -4133
Etfdh -4131
Cox4i1 -4072
Ndufb5 -4057
Ndufa5 -4041
Suclg1 -4032
Cox6b1 -4025
Uqcrc2 -3991
Ndufb7 -3979
Cox7c -3975
Sdha -3965
Sdhd -3918
Ndufb10 -3905
Fh1 -3862
Ndufb6 -3844
Atp5j -3812
Ndufs8 -3800
Sdhc -3753
Uqcrb -3746
Idh3g -3703
Sucla2 -3692
Ndufab1 -3635
Atp5l -3633
Ndufa3 -3619
Pdhx -3612
Atp5k -3609
Idh3b -3556
Atp5a1 -3555
Ogdh -3551
Cs -3543
Ndufa6 -3541
Ndufb9 -3506
Ndufb2 -3470
Suclg2 -3467
Ndufa4 -3465
Ndufc1 -3459
Atp5b -3457
Ndufb4 -3454
Idh3a -3394
Atp5c1 -3382
Slc16a1 -3374
Ndufa8 -3333
Pdha1 -3301
Dlst -3299
Pdk2 -3258
Ndufa2 -3252
Uqcrh -3215
Cox5a -3190
Dld -3079
Pdhb -3017
Ndufs5 -3015
Atp5o -2983
Ndufv2 -2930
Ndufa1 -2898
Ndufa10 -2845
Cox7a2l -2784
Pdp1 -2747
Ndufs7 -2469
Uqcr11 -2331
Ndufa13 -2071
Atp5h -1988
Atp5e -1869
Atp5d -1811
Ndufs3 -1785
Aco2 -1735
Ndufs2 -1712
Ndufc2 -1509
Ndufa7 -905
Ndufv3 37
Ndufa12 106
Pdp2 772
Slc16a3 1264
Cox8a 2301
D2hgdh 2446
Adhfe1 3343
Cox6a1 3381
Ldha 3498
Pdk4 3879
Ucp2 4352
Bsg 4409
Idh1 4524
Ucp3 4729


REACTOME_TRANSLATION

REACTOME_TRANSLATION
2
set REACTOME_TRANSLATION
setSize 124
pANOVA 6.94e-28
s.dist 0.57
p.adjustANOVA 3.28e-25



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif4b 4821
Eif2b3 4810
Eif4ebp1 4794
Eef1g 4780
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Eef2 4675
Rpl6 4629
Eif2s3x 4615
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Srp72 4488

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif4b 4821.0
Eif2b3 4810.0
Eif4ebp1 4794.0
Eef1g 4780.0
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Eef2 4675.0
Rpl6 4629.0
Eif2s3x 4615.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Srp72 4488.0
Rps3 4450.0
Ssr4 4448.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Rps23 4404.0
Eif3e 4402.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpn2 4122.0
Spcs2 4087.0
Rpl26 4052.0
Sec11c 4049.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Eif3i 3961.0
Rps6 3917.0
Rpl18 3853.0
Rpn1 3821.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Eif5 3727.0
Eif3c 3725.0
Rpl27a 3724.0
Eif3a 3701.0
Eif4h 3700.0
Rps18 3646.0
Eef1a1 3621.0
Rps26 3580.0
Eif3g 3568.0
Rpl23 3499.0
Eif3b 3490.0
Eif3d 3444.0
Rpl28 3412.0
Rpl41 3393.0
Eef1b2 3315.0
Ssr1 3277.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Rpl30 2992.0
Rps8 2985.0
Eef1d 2821.0
Eif2b2 2674.0
Eif3j2 2604.0
Eif4a2 2603.0
Eif2s2 2592.0
Rpl5 2573.0
Rps27a 2556.0
Ssr2 2545.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Eif3f 2135.0
Eif3k 2110.0
Ssr3 2094.0
Srp68 1849.0
Rps11 1720.0
Rpl29 1671.0
Rpl37a 1603.0
Eif4a1 1575.0
Sec61b 1573.0
Spcs1 1558.0
Eif4g1 1343.0
Uba52 1341.0
Ddost 1077.0
Eif2b4 1037.0
Sec11a 1007.0
Eif5b 923.0
Srp54a 876.0
Eif3h 855.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Rpl39 640.0
Sec61g 631.0
Spcs3 618.0
Rpl27-ps3 602.5
Sec61a2 600.0
Rps12-ps3 409.0
Etf1 61.0
Srp14 -77.0
Srprb -298.0
Srp9 -529.0
Eif2b1 -776.0
Eif1ax -848.0
Eif4e -1413.0
Eif2s1 -1528.0
Rpl3l -1613.0
Srp19 -1646.0
Sec61a1 -1805.0
Tram1 -2648.0
Eif2b5 -2790.0


REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION

REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
402
set REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
setSize 83
pANOVA 5.12e-19
s.dist 0.566
p.adjustANOVA 3.03e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Rpl6 4629
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Gtf2f1 4487
Rps3 4450
Rps19 4436
Rpl10a 4430
Rpsa 4416
Polr2a 4411
Rps23 4404

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Rpl6 4629.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Gtf2f1 4487.0
Rps3 4450.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Polr2a 4411.0
Rps23 4404.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpl26 4052.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Rps6 3917.0
Rpl18 3853.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Rpl27a 3724.0
Rps18 3646.0
Rps26 3580.0
Rpl23 3499.0
Rpl28 3412.0
Rpl41 3393.0
Gtf2f2 3255.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Polr2c 3011.0
Rpl30 2992.0
Rps8 2985.0
Rpl5 2573.0
Rps27a 2556.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Polr2h 1732.0
Rps11 1720.0
Rpl29 1671.0
Ipo5 1632.0
Rpl37a 1603.0
Uba52 1341.0
Polr2l 967.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Polr2i 742.0
Rpl39 640.0
Rpl27-ps3 602.5
Polr2g 466.0
Rps12-ps3 409.0
Polr2e -50.0
Grsf1 -119.0
Dnajc3 -252.0
Polr2b -361.0
Polr2d -627.0
Polr2j -1037.0
Rpl3l -1613.0
Polr2k -3171.0
Polr2f -3913.0
Hsp90aa1 -3982.0


REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
138
set REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
setSize 11
pANOVA 0.00202
s.dist -0.538
p.adjustANOVA 0.0354



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Pdpr -4133
Pdhx -3612
Pdha1 -3301
Pdk2 -3258
Dld -3079
Pdhb -3017
Pdp1 -2747
Pdp2 772
Pdk4 3879

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Pdpr -4133
Pdhx -3612
Pdha1 -3301
Pdk2 -3258
Dld -3079
Pdhb -3017
Pdp1 -2747
Pdp2 772
Pdk4 3879


REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX

REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
449
set REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX
setSize 85
pANOVA 4.6e-17
s.dist 0.527
p.adjustANOVA 2.42e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Rpl6 4629
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpl10a 4430
Rpsa 4416
Rps23 4404
Rpl13 4321
Rps5 4318

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Rpl6 4629.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Rps3 4450.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Rps23 4404.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpl26 4052.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Rps6 3917.0
Rpl18 3853.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Rpl27a 3724.0
Rps18 3646.0
Rps26 3580.0
Rpl23 3499.0
Casc3 3415.0
Rpl28 3412.0
Rpl41 3393.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Rpl30 2992.0
Rps8 2985.0
Rnps1 2750.0
Rpl5 2573.0
Rps27a 2556.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Ppp2ca 2241.0
Rps11 1720.0
Rpl29 1671.0
Rpl37a 1603.0
Eif4g1 1343.0
Uba52 1341.0
Eif4a3 1285.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Smg9 675.0
Rpl39 640.0
Rpl27-ps3 602.5
Upf2 537.0
Rps12-ps3 409.0
Etf1 61.0
Smg5 16.0
Ncbp2 -152.0
Upf3a -371.0
Smg7 -508.0
Ncbp1 -996.0
Magoh -1059.0
Upf3b -1300.0
Smg1 -1397.0
Rpl3l -1613.0
Ppp2r1a -1700.0
Smg8 -2340.0
Smg6 -2758.0
Ppp2r2a -2763.0


REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
1
set REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS
setSize 11
pANOVA 0.00301
s.dist 0.517
p.adjustANOVA 0.0491



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pygm 4135
Pygb 4125
Gyg 3611
Phka1 3607
Phkb 3466
Pgm1 2672
Phkg1 2489
Calm1 2437
Phkg2 1785
Phka2 936
Agl -1323

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pygm 4135
Pygb 4125
Gyg 3611
Phka1 3607
Phkb 3466
Pgm1 2672
Phkg1 2489
Calm1 2437
Phkg2 1785
Phka2 936
Agl -1323


REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
5
set REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE
setSize 38
pANOVA 1.21e-07
s.dist -0.496
p.adjustANOVA 3.02e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Idh2 -4590
Sdhb -4560
Ldhb -4534
L2hgdh -4480
Nnt -4443
Mdh2 -4214
Pdpr -4133
Suclg1 -4032
Sdha -3965
Sdhd -3918
Fh1 -3862
Sdhc -3753
Idh3g -3703
Sucla2 -3692
Pdhx -3612
Idh3b -3556
Ogdh -3551
Cs -3543

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Idh2 -4590
Sdhb -4560
Ldhb -4534
L2hgdh -4480
Nnt -4443
Mdh2 -4214
Pdpr -4133
Suclg1 -4032
Sdha -3965
Sdhd -3918
Fh1 -3862
Sdhc -3753
Idh3g -3703
Sucla2 -3692
Pdhx -3612
Idh3b -3556
Ogdh -3551
Cs -3543
Suclg2 -3467
Idh3a -3394
Slc16a1 -3374
Pdha1 -3301
Dlst -3299
Pdk2 -3258
Dld -3079
Pdhb -3017
Pdp1 -2747
Aco2 -1735
Pdp2 772
Slc16a3 1264
D2hgdh 2446
Adhfe1 3343
Ldha 3498
Pdk4 3879
Bsg 4409
Idh1 4524


REACTOME_INFLUENZA_LIFE_CYCLE

REACTOME_INFLUENZA_LIFE_CYCLE
401
set REACTOME_INFLUENZA_LIFE_CYCLE
setSize 115
pANOVA 1.01e-15
s.dist 0.434
p.adjustANOVA 4.77e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Rpl8 4679
Rpl6 4629
Rpl15 4611
Rps4x 4589
Rpl19 4581
Rpl12 4571
Rpl24 4507
Rps25 4502
Rps9 4497
Gtf2f1 4487
Rps3 4450
Rps19 4436
Rpl10a 4430
Rpsa 4416
Polr2a 4411
Rps23 4404

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Rpl8 4679.0
Rpl6 4629.0
Rpl15 4611.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Gtf2f1 4487.0
Rps3 4450.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Polr2a 4411.0
Rps23 4404.0
Rpl13 4321.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Ran 4088.0
Rpl26 4052.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Rps6 3917.0
Rpl18 3853.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Rpl27a 3724.0
Rps18 3646.0
Cltc 3596.0
Rps26 3580.0
Rpl23 3499.0
Nup155 3464.0
Rpl28 3412.0
Seh1l 3403.0
Rpl41 3393.0
Gtf2f2 3255.0
Rps15a 3213.0
Rpl22 3202.0
Clta 3143.0
Rps13 3137.0
Polr2c 3011.0
Rpl30 2992.0
Rps8 2985.0
Nup153 2762.0
Rpl5 2573.0
Rps27a 2556.0
Rplp2 2500.0
Rps17 2408.0
Rps29 2366.0
Calr 2260.0
Nup85 2167.0
Aaas 2132.0
Nup88 2027.0
Tpr 1975.0
Polr2h 1732.0
Rps11 1720.0
Canx 1678.0
Rpl29 1671.0
Kpnb1 1641.0
Ipo5 1632.0
Nup107 1629.0
Rpl37a 1603.0
Ranbp2 1444.0
Nup205 1419.0
Uba52 1341.0
Kpna1 1210.0
Polr2l 967.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Polr2i 742.0
Rpl39 640.0
Rpl27-ps3 602.5
Nup188 500.0
Polr2g 466.0
Rps12-ps3 409.0
Nup133 397.0
Nup43 334.0
Polr2e -50.0
Nup93 -85.0
Grsf1 -119.0
Dnajc3 -252.0
Polr2b -361.0
Polr2d -627.0
Rae1 -673.0
Nup35 -717.0
Polr2j -1037.0
Nup214 -1394.0
Nup62 -1503.0
Rpl3l -1613.0
Pom121 -1975.0
Nup210 -2539.0
Xpo1 -2589.0
Nupl2 -3005.0
Polr2k -3171.0
Nup37 -3180.0
Polr2f -3913.0
Hsp90aa1 -3982.0
Hspa1b -4137.0
Nup54 -4321.0


REACTOME_PYRUVATE_METABOLISM

REACTOME_PYRUVATE_METABOLISM
296
set REACTOME_PYRUVATE_METABOLISM
setSize 16
pANOVA 0.0134
s.dist -0.357
p.adjustANOVA 0.148



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Ldhb -4534
Pdpr -4133
Pdhx -3612
Slc16a1 -3374
Pdha1 -3301
Pdk2 -3258
Dld -3079
Pdhb -3017
Pdp1 -2747
Pdp2 772
Slc16a3 1264
Ldha 3498
Pdk4 3879
Bsg 4409

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdk1 -4603
Dlat -4601
Ldhb -4534
Pdpr -4133
Pdhx -3612
Slc16a1 -3374
Pdha1 -3301
Pdk2 -3258
Dld -3079
Pdhb -3017
Pdp1 -2747
Pdp2 772
Slc16a3 1264
Ldha 3498
Pdk4 3879
Bsg 4409


REACTOME_METABOLISM_OF_POLYAMINES

REACTOME_METABOLISM_OF_POLYAMINES
173
set REACTOME_METABOLISM_OF_POLYAMINES
setSize 12
pANOVA 0.0328
s.dist 0.356
p.adjustANOVA 0.259



Top enriched genes

Top 20 genes
GeneID Gene Rank
Odc1 4779
Sms 4672
Adi1 4354
Sat1 4009
Srm 3190
Mtap 2822
Smox 1825
Enoph1 567
Amd1 154
Mri1 -171
Apip -660
Got1 -4317

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Odc1 4779
Sms 4672
Adi1 4354
Sat1 4009
Srm 3190
Mtap 2822
Smox 1825
Enoph1 567
Amd1 154
Mri1 -171
Apip -660
Got1 -4317


REACTOME_MRNA_SPLICING

REACTOME_MRNA_SPLICING
219
set REACTOME_MRNA_SPLICING
setSize 99
pANOVA 1.59e-09
s.dist 0.352
p.adjustANOVA 4.69e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sf3b1 4817
Snrnp70 4776
Srsf5 4768
Hnrnpa1 4663
Cpsf7 4650
Dhx38 4639
Cdc40 4607
Srsf6 4558
Hnrnpm 4545
Srsf11 4542
Srsf7 4491
Gtf2f1 4487
Sf3b4 4486
Polr2a 4411
Hnrnpd 4381
Ptbp1 4376
Sf3b2 4265
Prpf6 4121
Srsf2 4115
Phf5a 4040

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sf3b1 4817
Snrnp70 4776
Srsf5 4768
Hnrnpa1 4663
Cpsf7 4650
Dhx38 4639
Cdc40 4607
Srsf6 4558
Hnrnpm 4545
Srsf11 4542
Srsf7 4491
Gtf2f1 4487
Sf3b4 4486
Polr2a 4411
Hnrnpd 4381
Ptbp1 4376
Sf3b2 4265
Prpf6 4121
Srsf2 4115
Phf5a 4040
Cstf1 3846
Snrpd1 3818
Snrpa1 3789
Sf3a3 3766
Hnrnpf 3748
U2af2 3692
Pcbp2 3689
Smc1a 3667
Ybx1 3473
Rbm5 3356
Hnrnpc 3355
Ccar1 3306
Gtf2f2 3255
Nfx1 3198
Snrpb2 3092
Polr2c 3011
Srsf3 2969
Hnrnpu 2898
Rnps1 2750
Hnrnpa2b1 2732
Sf3b5 2721
Sf3b3 2640
Hnrnph2 2625
Prpf4 2617
Eftud2 2547
Snrnp200 2516
Srrm1 2492
Sf3a1 2300
Hnrnpk 2213
Srsf1 2208
Cpsf1 2185
Hnrnpul1 2039
Pcbp1 1953
Hnrnpa0 1848
Prpf8 1840
Polr2h 1732
Snrpb 1666
Hnrnph1 1385
Hnrnpr 1379
Srsf9 1373
Snrpf 1230
U2af1 1215
Txnl4a 1121
Cd2bp2 1108
Fus 1087
Polr2l 967
Hnrnpl 935
Polr2i 742
Snrnp40 610
Dhx9 562
Sugp1 517
Polr2g 466
Hnrnpa3 420
Snrpe 405
Ddx23 160
Polr2e -50
Snrpd2 -120
Ncbp2 -152
Lsm2 -292
Polr2b -361
Sf3a2 -448
Polr2d -627
Ncbp1 -996
Polr2j -1037
Magoh -1059
Upf3b -1300
Snrpa -1483
Cpsf3 -1610
Pcf11 -1826
Cstf3 -1861
Dnajc8 -2309
Snrpd3 -2427
Cpsf2 -2452
Nudt21 -2491
Cstf2 -2515
Srsf4 -2541
Polr2k -3171
Polr2f -3913
Papola -4318


REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING

REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
59
set REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
setSize 13
pANOVA 0.0322
s.dist 0.343
p.adjustANOVA 0.259



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hbegf 4735
Ywhab 3781
Sos1 3769
Map2k2 3690
Map2k1 3099
Shc1 3005
Grb2 2546
Mapk3 1715
Mapk1 1049
Raf1 -20
Hras -263
Nras -1263
Kras -3644

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hbegf 4735
Ywhab 3781
Sos1 3769
Map2k2 3690
Map2k1 3099
Shc1 3005
Grb2 2546
Mapk3 1715
Mapk1 1049
Raf1 -20
Hras -263
Nras -1263
Kras -3644


REACTOME_SHC_MEDIATED_SIGNALLING

REACTOME_SHC_MEDIATED_SIGNALLING
414
set REACTOME_SHC_MEDIATED_SIGNALLING
setSize 13
pANOVA 0.035
s.dist 0.338
p.adjustANOVA 0.267



Top enriched genes

Top 20 genes
GeneID Gene Rank
Shc2 4407
Ywhab 3781
Sos1 3769
Map2k2 3690
Map2k1 3099
Shc1 3005
Grb2 2546
Mapk3 1715
Mapk1 1049
Raf1 -20
Hras -263
Nras -1263
Kras -3644

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Shc2 4407
Ywhab 3781
Sos1 3769
Map2k2 3690
Map2k1 3099
Shc1 3005
Grb2 2546
Mapk3 1715
Mapk1 1049
Raf1 -20
Hras -263
Nras -1263
Kras -3644


REACTOME_SHC_RELATED_EVENTS

REACTOME_SHC_RELATED_EVENTS
473
set REACTOME_SHC_RELATED_EVENTS
setSize 14
pANOVA 0.031
s.dist 0.333
p.adjustANOVA 0.257



Top enriched genes

Top 20 genes
GeneID Gene Rank
Shc2 4407
Ywhab 3781
Sos1 3769
Map2k2 3690
Map2k1 3099
Shc1 3005
Grb2 2546
Mapk3 1715
Insr 1358
Mapk1 1049
Raf1 -20
Hras -263
Nras -1263
Kras -3644

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Shc2 4407
Ywhab 3781
Sos1 3769
Map2k2 3690
Map2k1 3099
Shc1 3005
Grb2 2546
Mapk3 1715
Insr 1358
Mapk1 1049
Raf1 -20
Hras -263
Nras -1263
Kras -3644


REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT

REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT
381
set REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT
setSize 22
pANOVA 0.00762
s.dist 0.329
p.adjustANOVA 0.116



Top enriched genes

Top 20 genes
GeneID Gene Rank
Chmp2a 4124
Chmp5 3900
Chmp6 3874
Hgs 3467
Vps4a 2874
Vps25 2815
Vps37b 2624
Rps27a 2556
Vta1 2521
Chmp2b 2007
Vps36 1884
Stam2 1386
Chmp3 1377
Vps37a 1355
Uba52 1341
Chmp4b 1146
Vps37c 1032
Tsg101 212
Stam 156
Chmp7 -180

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Chmp2a 4124
Chmp5 3900
Chmp6 3874
Hgs 3467
Vps4a 2874
Vps25 2815
Vps37b 2624
Rps27a 2556
Vta1 2521
Chmp2b 2007
Vps36 1884
Stam2 1386
Chmp3 1377
Vps37a 1355
Uba52 1341
Chmp4b 1146
Vps37c 1032
Tsg101 212
Stam 156
Chmp7 -180
Snf8 -1930
Vps4b -2521


REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION

REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
182
set REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
setSize 22
pANOVA 0.00802
s.dist 0.327
p.adjustANOVA 0.119



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eprs 4777
Rars 4657
Farsb 4363
Iars 4002
Vars 3920
Farsa 3741
Kars 3318
Lars 3235
Wars 2673
Yars 2616
Aimp2 2606
Tars 1095
Dars 955
Sars 917
Gars 851
Qars 793
Aars 755
Nars 366
Aimp1 -281
Cars -2246

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eprs 4777
Rars 4657
Farsb 4363
Iars 4002
Vars 3920
Farsa 3741
Kars 3318
Lars 3235
Wars 2673
Yars 2616
Aimp2 2606
Tars 1095
Dars 955
Sars 917
Gars 851
Qars 793
Aars 755
Nars 366
Aimp1 -281
Cars -2246
Hars -3054
Ppa1 -4264


REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
65
set REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT
setSize 42
pANOVA 0.000283
s.dist -0.324
p.adjustANOVA 0.00558



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ldhd -4518
Timm13 -4423
Tomm22 -4348
Atp5g1 -4332
Cyc1 -4206
Bcs1l -4068
Pmpcb -3813
Hspa9 -3759
Idh3g -3703
Mtx2 -3700
Grpel1 -3620
Atp5a1 -3555
Cs -3543
Tomm20 -3519
Atp5b -3457
Hspd1 -3315
Tomm7 -3263
Slc25a4 -3246
Timm10 -3042
Timm22 -2995

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ldhd -4518
Timm13 -4423
Tomm22 -4348
Atp5g1 -4332
Cyc1 -4206
Bcs1l -4068
Pmpcb -3813
Hspa9 -3759
Idh3g -3703
Mtx2 -3700
Grpel1 -3620
Atp5a1 -3555
Cs -3543
Tomm20 -3519
Atp5b -3457
Hspd1 -3315
Tomm7 -3263
Slc25a4 -3246
Timm10 -3042
Timm22 -2995
Samm50 -2950
Timm8b -2831
Timm8a1 -2330
Mtx1 -2255
Grpel2 -2248
Aco2 -1735
Slc25a12 -1690
Timm44 -1368
Timm50 17
Tomm5 531
Hscb 573
Timm17b 1120
Timm17a 1244
Tomm40 1970
Pmpca 2006
Fxn 2025
Gfer 2768
Vdac1 2841
Timm23 3135
Dnajc19 3253
Timm9 3606
Coq2 4243


REACTOME_HS_GAG_BIOSYNTHESIS

REACTOME_HS_GAG_BIOSYNTHESIS
119
set REACTOME_HS_GAG_BIOSYNTHESIS
setSize 15
pANOVA 0.0356
s.dist -0.313
p.adjustANOVA 0.267



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hs3st5 -4738
Hs2st1 -4456
Hspg2 -4199
Ndst1 -3881
Sdc2 -3143
Gpc4 -2955
Glce -2423
Hs6st1 -2187
Ext2 -520
Gpc1 -384
Ext1 -158
Sdc4 296
Sdc3 1918
Agrn 2227
Ndst2 2976

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hs3st5 -4738
Hs2st1 -4456
Hspg2 -4199
Ndst1 -3881
Sdc2 -3143
Gpc4 -2955
Glce -2423
Hs6st1 -2187
Ext2 -520
Gpc1 -384
Ext1 -158
Sdc4 296
Sdc3 1918
Agrn 2227
Ndst2 2976


REACTOME_LAGGING_STRAND_SYNTHESIS

REACTOME_LAGGING_STRAND_SYNTHESIS
386
set REACTOME_LAGGING_STRAND_SYNTHESIS
setSize 11
pANOVA 0.0733
s.dist 0.312
p.adjustANOVA 0.365



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pold1 4771
Rpa1 4371
Rfc4 4308
Pold4 3575
Rfc2 3376
Pcna 3258
Rpa2 1806
Pold3 -795
Fen1 -1044
Pold2 -2794
Pola2 -3690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pold1 4771
Rpa1 4371
Rfc4 4308
Pold4 3575
Rfc2 3376
Pcna 3258
Rpa2 1806
Pold3 -795
Fen1 -1044
Pold2 -2794
Pola2 -3690


REACTOME_MRNA_SPLICING_MINOR_PATHWAY

REACTOME_MRNA_SPLICING_MINOR_PATHWAY
220
set REACTOME_MRNA_SPLICING_MINOR_PATHWAY
setSize 39
pANOVA 0.000812
s.dist 0.31
p.adjustANOVA 0.0154



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sf3b1 4817
Srsf6 4558
Srsf7 4491
Gtf2f1 4487
Sf3b4 4486
Polr2a 4411
Sf3b2 4265
Prpf6 4121
Srsf2 4115
Snrpd1 3818
Gtf2f2 3255
Polr2c 3011
Sf3b5 2721
Sf3b3 2640
Eftud2 2547
Snrnp200 2516
Srsf1 2208
Prpf8 1840
Polr2h 1732
Snrpb 1666

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sf3b1 4817
Srsf6 4558
Srsf7 4491
Gtf2f1 4487
Sf3b4 4486
Polr2a 4411
Sf3b2 4265
Prpf6 4121
Srsf2 4115
Snrpd1 3818
Gtf2f2 3255
Polr2c 3011
Sf3b5 2721
Sf3b3 2640
Eftud2 2547
Snrnp200 2516
Srsf1 2208
Prpf8 1840
Polr2h 1732
Snrpb 1666
Snrpf 1230
Txnl4a 1121
Polr2l 967
Polr2i 742
Snrnp40 610
Polr2g 466
Snrpe 405
Ddx23 160
Polr2e -50
Snrpd2 -120
Ncbp2 -152
Lsm2 -292
Polr2b -361
Polr2d -627
Ncbp1 -996
Polr2j -1037
Snrpd3 -2427
Polr2k -3171
Polr2f -3913


REACTOME_DNA_STRAND_ELONGATION

REACTOME_DNA_STRAND_ELONGATION
462
set REACTOME_DNA_STRAND_ELONGATION
setSize 14
pANOVA 0.0519
s.dist 0.3
p.adjustANOVA 0.319



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pold1 4771
Rpa1 4371
Rfc4 4308
Mcm2 3992
Pold4 3575
Rfc2 3376
Pcna 3258
Mcm7 3012
Rpa2 1806
Pold3 -795
Fen1 -1044
Pold2 -2794
Gins4 -3131
Pola2 -3690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pold1 4771
Rpa1 4371
Rfc4 4308
Mcm2 3992
Pold4 3575
Rfc2 3376
Pcna 3258
Mcm7 3012
Rpa2 1806
Pold3 -795
Fen1 -1044
Pold2 -2794
Gins4 -3131
Pola2 -3690


REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS
31
set REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS
setSize 10
pANOVA 0.101
s.dist -0.3
p.adjustANOVA 0.425



Top enriched genes

Top 20 genes
GeneID Gene Rank
Abca9 -3956
Abca2 -3846
Abca6 -3224
Abcd3 -2257
Pex3 -1776
Pex19 -961
Abca3 -535
Abca7 375
Abcd1 590
Abcd2 1816

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Abca9 -3956
Abca2 -3846
Abca6 -3224
Abcd3 -2257
Pex3 -1776
Pex19 -961
Abca3 -535
Abca7 375
Abcd1 590
Abcd2 1816


REACTOME_EXTENSION_OF_TELOMERES

REACTOME_EXTENSION_OF_TELOMERES
458
set REACTOME_EXTENSION_OF_TELOMERES
setSize 16
pANOVA 0.0404
s.dist 0.296
p.adjustANOVA 0.294



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pold1 4771
Rpa1 4371
Rfc4 4308
Dkc1 4285
Pold4 3575
Rfc2 3376
Pcna 3258
Wrap53 2990
Rpa2 1806
Ruvbl1 1545
Nhp2 292
Pold3 -795
Fen1 -1044
Ruvbl2 -2552
Pold2 -2794
Pola2 -3690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pold1 4771
Rpa1 4371
Rfc4 4308
Dkc1 4285
Pold4 3575
Rfc2 3376
Pcna 3258
Wrap53 2990
Rpa2 1806
Ruvbl1 1545
Nhp2 292
Pold3 -795
Fen1 -1044
Ruvbl2 -2552
Pold2 -2794
Pola2 -3690


REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA
136
set REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA
setSize 126
pANOVA 1.24e-08
s.dist 0.295
p.adjustANOVA 3.26e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sf3b1 4817
Snrnp70 4776
Srsf5 4768
Hnrnpa1 4663
Cpsf7 4650
Dhx38 4639
Cdc40 4607
Srsf6 4558
Hnrnpm 4545
Srsf11 4542
Srsf7 4491
Gtf2f1 4487
Sf3b4 4486
Mettl3 4443
Polr2a 4411
Hnrnpd 4381
Ptbp1 4376
Sf3b2 4265
Prpf6 4121
Srsf2 4115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sf3b1 4817
Snrnp70 4776
Srsf5 4768
Hnrnpa1 4663
Cpsf7 4650
Dhx38 4639
Cdc40 4607
Srsf6 4558
Hnrnpm 4545
Srsf11 4542
Srsf7 4491
Gtf2f1 4487
Sf3b4 4486
Mettl3 4443
Polr2a 4411
Hnrnpd 4381
Ptbp1 4376
Sf3b2 4265
Prpf6 4121
Srsf2 4115
Phf5a 4040
Nxf1 3910
Cstf1 3846
Snrpd1 3818
Snrpa1 3789
Sf3a3 3766
Hnrnpf 3748
U2af2 3692
Pcbp2 3689
Smc1a 3667
Ybx1 3473
Nup155 3464
Seh1l 3403
Rbm5 3356
Hnrnpc 3355
Ccar1 3306
Gtf2f2 3255
Nfx1 3198
Snrpb2 3092
Polr2c 3011
Srsf3 2969
Hnrnpu 2898
Nup153 2762
Rnps1 2750
Hnrnpa2b1 2732
Sf3b5 2721
Sf3b3 2640
Hnrnph2 2625
Prpf4 2617
Eftud2 2547
Snrnp200 2516
Srrm1 2492
Sf3a1 2300
Hnrnpk 2213
Srsf1 2208
Cpsf1 2185
Nup85 2167
Aaas 2132
Hnrnpul1 2039
Nup88 2027
Tpr 1975
Pcbp1 1953
Hnrnpa0 1848
Prpf8 1840
Polr2h 1732
Snrpb 1666
Nup107 1629
Ranbp2 1444
Nup205 1419
Hnrnph1 1385
Hnrnpr 1379
Srsf9 1373
Snrpf 1230
U2af1 1215
Txnl4a 1121
Cd2bp2 1108
Fus 1087
Polr2l 967
Hnrnpl 935
Slbp 884
Polr2i 742
Snrnp40 610
Dhx9 562
Sugp1 517
Nup188 500
Polr2g 466
Hnrnpa3 420
Snrpe 405
Nup133 397
Nup43 334
Ddx23 160
Polr2e -50
Nup93 -85
Snrpd2 -120
Ncbp2 -152
Lsm2 -292
Polr2b -361
Sf3a2 -448
Polr2d -627
Rae1 -673
Nup35 -717
Ncbp1 -996
Polr2j -1037
Magoh -1059
Upf3b -1300
Nup214 -1394
Eif4e -1413
Snrpa -1483
Nup62 -1503
Cpsf3 -1610
Pcf11 -1826
Cstf3 -1861
Pom121 -1975
Dnajc8 -2309
Snrpd3 -2427
Cpsf2 -2452
Nudt21 -2491
Cstf2 -2515
Nup210 -2539
Srsf4 -2541
Nupl2 -3005
Polr2k -3171
Nup37 -3180
Polr2f -3913
Papola -4318
Nup54 -4321


REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM
121
set REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM
setSize 25
pANOVA 0.0111
s.dist -0.294
p.adjustANOVA 0.142



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hs3st5 -4738
Hs2st1 -4456
Hspg2 -4199
Gusb -4160
Ndst1 -3881
Sdc2 -3143
Gpc4 -2955
Glce -2423
B4galt7 -2201
Hs6st1 -2187
Dcn -1874
Gxylt1 -1737
Idua -1380
Naglu -891
Ids -687
Ext2 -520
Gpc1 -384
Ext1 -158
Bgn 255
Vcan 263

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hs3st5 -4738
Hs2st1 -4456
Hspg2 -4199
Gusb -4160
Ndst1 -3881
Sdc2 -3143
Gpc4 -2955
Glce -2423
B4galt7 -2201
Hs6st1 -2187
Dcn -1874
Gxylt1 -1737
Idua -1380
Naglu -891
Ids -687
Ext2 -520
Gpc1 -384
Ext1 -158
Bgn 255
Vcan 263
Sdc4 296
B3gat3 418
Sdc3 1918
Agrn 2227
Ndst2 2976


REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT

REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT
191
set REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT
setSize 17
pANOVA 0.0413
s.dist -0.286
p.adjustANOVA 0.296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Abcb1a -4735
Abca8b -4665
Abca9 -3956
Abcb10 -3925
Abca2 -3846
Abcc5 -3565
Abca6 -3224
Abcd3 -2257
Pex3 -1776
Pex19 -961
Abca3 -535
Abca7 375
Abcd1 590
Abcd2 1816
Abcc9 2508
Abcc4 2572
Abcb6 3320

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Abcb1a -4735
Abca8b -4665
Abca9 -3956
Abcb10 -3925
Abca2 -3846
Abcc5 -3565
Abca6 -3224
Abcd3 -2257
Pex3 -1776
Pex19 -961
Abca3 -535
Abca7 375
Abcd1 590
Abcd2 1816
Abcc9 2508
Abcc4 2572
Abcb6 3320


REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY

REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY
212
set REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY
setSize 11
pANOVA 0.104
s.dist 0.283
p.adjustANOVA 0.43



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tuba4a 4716
Tubb4b 4066
Tbcd 3180
Tbcb 2601
Tuba1b 1830
Tuba1a 1677
Tbce 1613
Tbcc 1376
Tbca 947
Tubb6 -2828
Tubb2a -3542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tuba4a 4716
Tubb4b 4066
Tbcd 3180
Tbcb 2601
Tuba1b 1830
Tuba1a 1677
Tbce 1613
Tbcc 1376
Tbca 947
Tubb6 -2828
Tubb2a -3542


REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE

REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE
17
set REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE
setSize 14
pANOVA 0.0679
s.dist -0.282
p.adjustANOVA 0.365



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp2r5e -3756
Ppp2r5d -3662
Ppp2r5b -3347
Apc -3312
Frat2 -2471
Ppp2r5c -2214
Ctnnb1 -2023
Ppp2r1a -1700
Ppp2r5a -1202
Ppp2cb -1021
Csnk1a1 -310
Axin1 236
Ppp2ca 2241
Ppp2r1b 4471

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2r5e -3756
Ppp2r5d -3662
Ppp2r5b -3347
Apc -3312
Frat2 -2471
Ppp2r5c -2214
Ctnnb1 -2023
Ppp2r1a -1700
Ppp2r5a -1202
Ppp2cb -1021
Csnk1a1 -310
Axin1 236
Ppp2ca 2241
Ppp2r1b 4471


REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION

REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
359
set REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
setSize 13
pANOVA 0.0826
s.dist 0.278
p.adjustANOVA 0.39



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nfkbib 4576
Nfkbia 4573
Traf2 3896
Ikbkb 3614
Ikbkg 3602
Map3k1 2438
Chuk 1332
Trim25 706
Rela 403
Nfkb2 222
Traf6 -381
App -2953
Mavs -3887

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nfkbib 4576
Nfkbia 4573
Traf2 3896
Ikbkb 3614
Ikbkg 3602
Map3k1 2438
Chuk 1332
Trim25 706
Rela 403
Nfkb2 222
Traf6 -381
App -2953
Mavs -3887


REACTOME_CELL_JUNCTION_ORGANIZATION

REACTOME_CELL_JUNCTION_ORGANIZATION
295
set REACTOME_CELL_JUNCTION_ORGANIZATION
setSize 30
pANOVA 0.00898
s.dist -0.276
p.adjustANOVA 0.125



Top enriched genes

Top 20 genes
GeneID Gene Rank
Lamb3 -4689
Itgb1 -4584
Cdh5 -4295
Parvb -4035
Lims1 -3968
Jup -3902
Cdh4 -3320
Pard6a -3191
Flnc -3067
Cldn5 -3043
F11r -2700
Plec -2651
Pvr -2174
Ctnnb1 -2023
Parva -1852
Pard3 -1722
Rsu1 -1603
Cd151 -1270
Cdh13 -1095
Cdh15 -800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lamb3 -4689
Itgb1 -4584
Cdh5 -4295
Parvb -4035
Lims1 -3968
Jup -3902
Cdh4 -3320
Pard6a -3191
Flnc -3067
Cldn5 -3043
F11r -2700
Plec -2651
Pvr -2174
Ctnnb1 -2023
Parva -1852
Pard3 -1722
Rsu1 -1603
Cd151 -1270
Cdh13 -1095
Cdh15 -800
Tesk1 -740
Actn1 -456
Vasp -308
Arhgef6 993
Fermt2 1504
Prkci 1901
Ilk 3059
Ctnna1 3584
Cldn12 4237
Cadm1 4437


REACTOME_METABOLISM_OF_MRNA

REACTOME_METABOLISM_OF_MRNA
289
set REACTOME_METABOLISM_OF_MRNA
setSize 179
pANOVA 2.48e-10
s.dist 0.275
p.adjustANOVA 8.38e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif4b 4821
Rpl14 4770
Rpl4 4765
Rplp0 4710
Rps3a1 4686
Psmd4 4682
Rpl8 4679
Rpl6 4629
Rpl15 4611
Psmc3 4606
Rps4x 4589
Rpl19 4581
Rpl12 4571
Psmd7 4553
Rpl24 4507
Rps25 4502
Rps9 4497
Rps3 4450
Rps19 4436
Rpl10a 4430

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif4b 4821.0
Rpl14 4770.0
Rpl4 4765.0
Rplp0 4710.0
Rps3a1 4686.0
Psmd4 4682.0
Rpl8 4679.0
Rpl6 4629.0
Rpl15 4611.0
Psmc3 4606.0
Rps4x 4589.0
Rpl19 4581.0
Rpl12 4571.0
Psmd7 4553.0
Rpl24 4507.0
Rps25 4502.0
Rps9 4497.0
Rps3 4450.0
Rps19 4436.0
Rpl10a 4430.0
Rpsa 4416.0
Rps23 4404.0
Exosc2 4389.0
Hnrnpd 4381.0
Exosc3 4374.0
Psmd8 4328.0
Rpl13 4321.0
Psma6 4319.0
Rps5 4318.0
Rps24 4294.0
Rps16 4280.0
Rpl36al 4262.0
Rpl38 4244.0
Rpl32 4229.0
Rps27 4182.0
Rps21 4146.0
Rpl26 4052.0
Rpl35 4030.0
Rpl3 4029.0
Rps20 4006.0
Rpl23a 4004.0
Rps14 3999.0
Rps6 3917.0
Cnot10 3856.0
Rpl18 3853.0
Ywhab 3781.0
Rpl18a 3758.0
Rpl37 3754.0
Rps7 3747.0
Rpl27a 3724.0
Rps18 3646.0
Rps26 3580.0
Rpl23 3499.0
Casc3 3415.0
Rpl28 3412.0
Rpl41 3393.0
Rps15a 3213.0
Rpl22 3202.0
Rps13 3137.0
Cnot2 3024.0
Rpl30 2992.0
Rps8 2985.0
Rnps1 2750.0
Khsrp 2748.0
Psmb1 2717.0
Eif4a2 2603.0
Rpl5 2573.0
Rps27a 2556.0
Rplp2 2500.0
Psmd2 2476.0
Psma4 2431.0
Rps17 2408.0
Rps29 2366.0
Psmd1 2316.0
Psma3 2261.0
Ppp2ca 2241.0
Psmb5 2219.0
Edc3 2080.0
Edc4 2069.0
Psmb7 2061.0
Psmc1 2002.0
Psma7 1967.0
Exosc5 1938.0
Elavl1 1876.0
Exosc1 1874.0
Rps11 1720.0
Ddx6 1701.0
Psmd3 1700.0
Psme4 1682.0
Rpl29 1671.0
Psmb2 1667.0
Rpl37a 1603.0
Eif4a1 1575.0
Psmb10 1532.0
Zfp36 1467.0
Lsm4 1403.0
Eif4g1 1343.0
Uba52 1341.0
Eif4a3 1285.0
Psme1 1158.0
Lsm1 1130.0
Xrn1 942.0
Psmd12 878.0
Rpl34 819.0
Rplp1 798.0
Rpl11 760.0
Smg9 675.0
Rpl39 640.0
Rpl27-ps3 602.5
Upf2 537.0
Zfp36l1 498.0
Psma5 410.0
Rps12-ps3 409.0
Paip1 377.0
Psma2 299.0
Psma1 291.0
Psmd11 276.0
Tnks1bp1 90.0
Etf1 61.0
Mapkapk2 40.0
Smg5 16.0
Exosc4 3.0
Psmc2 -122.0
Ncbp2 -152.0
Lsm6 -184.0
Cnot8 -232.0
Lsm2 -292.0
Exosc8 -304.0
Cnot7 -329.0
Upf3a -371.0
Cnot4 -441.0
Psmd9 -468.0
Hspa8 -476.0
Smg7 -508.0
Exosc9 -512.0
Parn -543.0
Psmb4 -752.0
Lsm5 -809.0
Psmd6 -842.0
Psmb6 -860.0
Ncbp1 -996.0
Magoh -1059.0
Psmd5 -1138.0
Psmd14 -1268.0
Upf3b -1300.0
Dcp1a -1324.0
Psmc5 -1367.0
Nup214 -1394.0
Smg1 -1397.0
Psmc4 -1398.0
Mapk14 -1399.0
Eif4e -1413.0
Patl1 -1418.0
Rpl3l -1613.0
Cnot3 -1664.0
Ppp2r1a -1700.0
Psmc6 -1749.0
Dis3 -1762.0
Lsm3 -2021.0
Tnpo1 -2273.0
Smg8 -2340.0
Psmd13 -2408.0
Anp32a -2410.0
Exosc7 -2504.0
Xpo1 -2589.0
Prkca -2730.0
Smg6 -2758.0
Ppp2r2a -2763.0
Prkcd -2769.0
Cnot6 -3001.0
Dcp2 -3138.0
Psmb8 -3196.0
Psmb3 -3274.0
Psmd10 -3627.0
Dcps -3933.0
Psmf1 -3990.0
Hspa1b -4137.0
Hspb1 -4286.0
Akt1 -4319.0


REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC

REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
210
set REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC
setSize 13
pANOVA 0.0858
s.dist 0.275
p.adjustANOVA 0.39



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tuba4a 4716
Cct4 4206
Tubb4b 4066
Cct7 4037
Cct2 3906
Tcp1 3404
Tuba1b 1830
Tuba1a 1677
Cct8 877
Cct5 -268
Tubb6 -2828
Tubb2a -3542
Cct3 -4118

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tuba4a 4716
Cct4 4206
Tubb4b 4066
Cct7 4037
Cct2 3906
Tcp1 3404
Tuba1b 1830
Tuba1a 1677
Cct8 877
Cct5 -268
Tubb6 -2828
Tubb2a -3542
Cct3 -4118


REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS

REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
223
set REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
setSize 11
pANOVA 0.115
s.dist 0.274
p.adjustANOVA 0.44



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adss 4803
Paics 3883
Impdh2 3114
Pfas 2960
Impdh1 2667
Ppat 2254
Atic 2194
Adssl1 555
Gmps -1523
Gart -2012
Adsl -3733

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adss 4803
Paics 3883
Impdh2 3114
Pfas 2960
Impdh1 2667
Ppat 2254
Atic 2194
Adssl1 555
Gmps -1523
Gart -2012
Adsl -3733


REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS

REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
293
set REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS
setSize 12
pANOVA 0.0999
s.dist -0.274
p.adjustANOVA 0.425



Top enriched genes

Top 20 genes
GeneID Gene Rank
Itgb1 -4584
Parvb -4035
Lims1 -3968
Flnc -3067
Parva -1852
Rsu1 -1603
Tesk1 -740
Actn1 -456
Vasp -308
Arhgef6 993
Fermt2 1504
Ilk 3059

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itgb1 -4584
Parvb -4035
Lims1 -3968
Flnc -3067
Parva -1852
Rsu1 -1603
Tesk1 -740
Actn1 -456
Vasp -308
Arhgef6 993
Fermt2 1504
Ilk 3059


REACTOME_MTORC1_MEDIATED_SIGNALLING

REACTOME_MTORC1_MEDIATED_SIGNALLING
437
set REACTOME_MTORC1_MEDIATED_SIGNALLING
setSize 11
pANOVA 0.117
s.dist 0.273
p.adjustANOVA 0.44



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif4b 4821
Eif4ebp1 4794
Rps6 3917
Eef2k 2649
Eif4g1 1343
Rps6kb1 1082
Mlst8 785
Mtor -623
Rptor -852
Eif4e -1413
Rheb -1416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif4b 4821
Eif4ebp1 4794
Rps6 3917
Eef2k 2649
Eif4g1 1343
Rps6kb1 1082
Mlst8 785
Mtor -623
Rptor -852
Eif4e -1413
Rheb -1416


REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM

REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
276
set REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM
setSize 16
pANOVA 0.0645
s.dist -0.267
p.adjustANOVA 0.365



Top enriched genes

Top 20 genes
GeneID Gene Rank
Auh -4377
Acat1 -4297
Dbt -4232
Bckdha -3717
Acad8 -3616
Dld -3079
Hibch -2598
Ivd -2571
Mccc1 -2038
Hibadh -283
Bcat2 95
Acadsb 614
Mccc2 1090
Bckdhb 1129
Aldh6a1 4094
Hsd17b10 4281

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Auh -4377
Acat1 -4297
Dbt -4232
Bckdha -3717
Acad8 -3616
Dld -3079
Hibch -2598
Ivd -2571
Mccc1 -2038
Hibadh -283
Bcat2 95
Acadsb 614
Mccc2 1090
Bckdhb 1129
Aldh6a1 4094
Hsd17b10 4281


REACTOME_SULFUR_AMINO_ACID_METABOLISM

REACTOME_SULFUR_AMINO_ACID_METABOLISM
50
set REACTOME_SULFUR_AMINO_ACID_METABOLISM
setSize 19
pANOVA 0.044
s.dist 0.267
p.adjustANOVA 0.298



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mat2a 4845
Ahcy 4809
Gclc 4690
Mtr 4666
Slc25a10 4485
Adi1 4354
Gclm 3804
Csad 3390
Mtap 2822
Cndp2 2497
Suox 654
Enoph1 567
Mri1 -171
Apip -660
Tst -1891
Ethe1 -2119
Cdo1 -2977
Mat2b -3962
Got1 -4317

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mat2a 4845
Ahcy 4809
Gclc 4690
Mtr 4666
Slc25a10 4485
Adi1 4354
Gclm 3804
Csad 3390
Mtap 2822
Cndp2 2497
Suox 654
Enoph1 567
Mri1 -171
Apip -660
Tst -1891
Ethe1 -2119
Cdo1 -2977
Mat2b -3962
Got1 -4317


REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC

REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
447
set REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC
setSize 14
pANOVA 0.0842
s.dist 0.267
p.adjustANOVA 0.39



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sec24b 4329
Tap2 3904
Sec31a 2975
Sec23a 2793
B2m 2697
Calr 2260
Sec13 1889
Canx 1678
Sar1b 1477
Hspa5 1103
Sec24d -1165
Erap1 -1211
Pdia3 -1391
Sec24c -2575

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sec24b 4329
Tap2 3904
Sec31a 2975
Sec23a 2793
B2m 2697
Calr 2260
Sec13 1889
Canx 1678
Sar1b 1477
Hspa5 1103
Sec24d -1165
Erap1 -1211
Pdia3 -1391
Sec24c -2575


REACTOME_HS_GAG_DEGRADATION

REACTOME_HS_GAG_DEGRADATION
98
set REACTOME_HS_GAG_DEGRADATION
setSize 11
pANOVA 0.127
s.dist -0.266
p.adjustANOVA 0.451



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspg2 -4199
Gusb -4160
Sdc2 -3143
Gpc4 -2955
Idua -1380
Naglu -891
Ids -687
Gpc1 -384
Sdc4 296
Sdc3 1918
Agrn 2227

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspg2 -4199
Gusb -4160
Sdc2 -3143
Gpc4 -2955
Idua -1380
Naglu -891
Ids -687
Gpc1 -384
Sdc4 296
Sdc3 1918
Agrn 2227


REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS

REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS
418
set REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS
setSize 16
pANOVA 0.0707
s.dist 0.261
p.adjustANOVA 0.365



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atrip 4742
Rpa1 4371
Rfc4 4308
Orc5 4010
Mcm2 3992
Rfc2 3376
Mcm7 3012
Rpa2 1806
Rad17 1592
Orc6 1253
Atr 162
Hus1 -1131
Orc3 -1556
Cdc25a -2362
Orc2 -2903
Orc4 -3653

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atrip 4742
Rpa1 4371
Rfc4 4308
Orc5 4010
Mcm2 3992
Rfc2 3376
Mcm7 3012
Rpa2 1806
Rad17 1592
Orc6 1253
Atr 162
Hus1 -1131
Orc3 -1556
Cdc25a -2362
Orc2 -2903
Orc4 -3653


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report