date generated: 2022-09-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     stat
## 0610009B22Rik -0.3845554
## 0610009L18Rik  0.7909020
## 0610010K14Rik  0.5031172
## 0610012G03Rik -0.5693632
## 0610030E20Rik  1.1957467
## 0610040J01Rik -1.1105356
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 674
num_genes_in_profile 9282
duplicated_genes_present 0
num_profile_genes_in_sets 2753
num_profile_genes_not_in_sets 6529

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: https://ziemann-lab.net/public/msigdb_mouse/reactome.v5.2.symbols_mouse.gmt
Gene sets metrics
Gene sets metrics
num_genesets 674
num_genesets_excluded 211
num_genesets_included 463

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REACTOME SIGNALING BY HIPPO 15 1.69e-05 -0.642 0.00782
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 11 5.48e-03 0.484 0.47900
REACTOME METAL ION SLC TRANSPORTERS 12 2.60e-02 0.371 0.50000
REACTOME COLLAGEN FORMATION 26 1.54e-03 0.359 0.35600
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 24 3.84e-03 0.341 0.47900
REACTOME PHOSPHORYLATION OF THE APC C 14 2.73e-02 -0.341 0.50000
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 5.16e-02 0.339 0.57800
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 15 2.38e-02 -0.337 0.50000
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 14 2.90e-02 0.337 0.50000
REACTOME TRAFFICKING OF AMPA RECEPTORS 16 2.59e-02 -0.322 0.50000
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 4.69e-02 0.318 0.57800
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 11 7.02e-02 -0.315 0.67100
REACTOME STRIATED MUSCLE CONTRACTION 22 1.09e-02 0.314 0.47900
REACTOME GLUCONEOGENESIS 19 1.89e-02 -0.311 0.47900
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 5.24e-02 -0.300 0.57800
REACTOME CELL CELL JUNCTION ORGANIZATION 15 4.94e-02 -0.293 0.57800
REACTOME INSULIN RECEPTOR RECYCLING 15 5.07e-02 0.292 0.57800
REACTOME BOTULINUM NEUROTOXICITY 10 1.17e-01 0.286 0.71900
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS 10 1.17e-01 0.286 0.71900
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 22 2.05e-02 0.286 0.47900
REACTOME NCAM1 INTERACTIONS 17 4.43e-02 0.282 0.57800
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 17 4.63e-02 -0.279 0.57800
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 16 5.37e-02 -0.279 0.57800
REACTOME INTERFERON GAMMA SIGNALING 21 2.95e-02 -0.275 0.50000
REACTOME SOS MEDIATED SIGNALLING 13 9.09e-02 -0.271 0.70200
REACTOME GLUCOSE TRANSPORT 29 1.23e-02 0.269 0.47900
REACTOME IRON UPTAKE AND TRANSPORT 23 2.73e-02 0.266 0.50000
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 11 1.32e-01 -0.262 0.71900
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 1.03e-01 0.262 0.71900
REACTOME PURINE SALVAGE 10 1.54e-01 -0.260 0.71900
REACTOME PLATELET SENSITIZATION BY LDL 11 1.36e-01 -0.260 0.71900
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 31 1.38e-02 0.256 0.47900
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 15 8.93e-02 -0.253 0.70200
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 1.47e-01 0.253 0.71900
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 5.11e-02 -0.252 0.57800
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 14 1.06e-01 -0.250 0.71900
REACTOME RNA POL III TRANSCRIPTION TERMINATION 18 6.76e-02 -0.249 0.67100
REACTOME RNA POL III CHAIN ELONGATION 16 9.09e-02 -0.244 0.70200
REACTOME O LINKED GLYCOSYLATION OF MUCINS 10 1.82e-01 -0.244 0.71900
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 17 8.40e-02 0.242 0.68200
REACTOME SHC MEDIATED SIGNALLING 13 1.48e-01 -0.232 0.71900
REACTOME EXTENSION OF TELOMERES 13 1.49e-01 -0.231 0.71900
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 12 1.75e-01 0.226 0.71900
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 13 1.59e-01 -0.226 0.71900
REACTOME BASIGIN INTERACTIONS 14 1.49e-01 0.223 0.71900
REACTOME GPVI MEDIATED ACTIVATION CASCADE 16 1.26e-01 0.221 0.71900
REACTOME ION CHANNEL TRANSPORT 18 1.05e-01 0.221 0.71900
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 41 1.68e-02 -0.216 0.47900
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 23 7.39e-02 0.215 0.67100
REACTOME MRNA 3 END PROCESSING 31 4.05e-02 0.213 0.57800


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME SIGNALING BY HIPPO 15 1.69e-05 -0.642000 0.00782
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 11 5.48e-03 0.484000 0.47900
REACTOME METAL ION SLC TRANSPORTERS 12 2.60e-02 0.371000 0.50000
REACTOME COLLAGEN FORMATION 26 1.54e-03 0.359000 0.35600
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 24 3.84e-03 0.341000 0.47900
REACTOME PHOSPHORYLATION OF THE APC C 14 2.73e-02 -0.341000 0.50000
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 5.16e-02 0.339000 0.57800
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 15 2.38e-02 -0.337000 0.50000
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 14 2.90e-02 0.337000 0.50000
REACTOME TRAFFICKING OF AMPA RECEPTORS 16 2.59e-02 -0.322000 0.50000
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 13 4.69e-02 0.318000 0.57800
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 11 7.02e-02 -0.315000 0.67100
REACTOME STRIATED MUSCLE CONTRACTION 22 1.09e-02 0.314000 0.47900
REACTOME GLUCONEOGENESIS 19 1.89e-02 -0.311000 0.47900
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 5.24e-02 -0.300000 0.57800
REACTOME CELL CELL JUNCTION ORGANIZATION 15 4.94e-02 -0.293000 0.57800
REACTOME INSULIN RECEPTOR RECYCLING 15 5.07e-02 0.292000 0.57800
REACTOME BOTULINUM NEUROTOXICITY 10 1.17e-01 0.286000 0.71900
REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS 10 1.17e-01 0.286000 0.71900
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 22 2.05e-02 0.286000 0.47900
REACTOME NCAM1 INTERACTIONS 17 4.43e-02 0.282000 0.57800
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 17 4.63e-02 -0.279000 0.57800
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 16 5.37e-02 -0.279000 0.57800
REACTOME INTERFERON GAMMA SIGNALING 21 2.95e-02 -0.275000 0.50000
REACTOME SOS MEDIATED SIGNALLING 13 9.09e-02 -0.271000 0.70200
REACTOME GLUCOSE TRANSPORT 29 1.23e-02 0.269000 0.47900
REACTOME IRON UPTAKE AND TRANSPORT 23 2.73e-02 0.266000 0.50000
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 11 1.32e-01 -0.262000 0.71900
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 13 1.03e-01 0.262000 0.71900
REACTOME PURINE SALVAGE 10 1.54e-01 -0.260000 0.71900
REACTOME PLATELET SENSITIZATION BY LDL 11 1.36e-01 -0.260000 0.71900
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 31 1.38e-02 0.256000 0.47900
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 15 8.93e-02 -0.253000 0.70200
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 11 1.47e-01 0.253000 0.71900
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 5.11e-02 -0.252000 0.57800
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 14 1.06e-01 -0.250000 0.71900
REACTOME RNA POL III TRANSCRIPTION TERMINATION 18 6.76e-02 -0.249000 0.67100
REACTOME RNA POL III CHAIN ELONGATION 16 9.09e-02 -0.244000 0.70200
REACTOME O LINKED GLYCOSYLATION OF MUCINS 10 1.82e-01 -0.244000 0.71900
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 17 8.40e-02 0.242000 0.68200
REACTOME SHC MEDIATED SIGNALLING 13 1.48e-01 -0.232000 0.71900
REACTOME EXTENSION OF TELOMERES 13 1.49e-01 -0.231000 0.71900
REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 12 1.75e-01 0.226000 0.71900
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 13 1.59e-01 -0.226000 0.71900
REACTOME BASIGIN INTERACTIONS 14 1.49e-01 0.223000 0.71900
REACTOME GPVI MEDIATED ACTIVATION CASCADE 16 1.26e-01 0.221000 0.71900
REACTOME ION CHANNEL TRANSPORT 18 1.05e-01 0.221000 0.71900
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 41 1.68e-02 -0.216000 0.47900
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 23 7.39e-02 0.215000 0.67100
REACTOME MRNA 3 END PROCESSING 31 4.05e-02 0.213000 0.57800
REACTOME PYRUVATE METABOLISM 16 1.42e-01 0.212000 0.71900
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 10 2.47e-01 0.211000 0.78400
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 17 1.32e-01 -0.211000 0.71900
REACTOME RECYCLING PATHWAY OF L1 19 1.13e-01 0.210000 0.71900
REACTOME MUSCLE CONTRACTION 36 3.02e-02 0.209000 0.50000
REACTOME GLYCOSPHINGOLIPID METABOLISM 20 1.07e-01 -0.208000 0.71900
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 28 6.13e-02 0.204000 0.63100
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 21 1.05e-01 -0.204000 0.71900
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 16 1.59e-01 -0.203000 0.71900
REACTOME TELOMERE MAINTENANCE 17 1.47e-01 -0.203000 0.71900
REACTOME ION TRANSPORT BY P TYPE ATPASES 17 1.50e-01 0.202000 0.71900
REACTOME SIGNALING BY NOTCH3 10 2.71e-01 -0.201000 0.78600
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 10 2.75e-01 -0.199000 0.78600
REACTOME PEPTIDE CHAIN ELONGATION 66 6.10e-03 -0.196000 0.47900
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 22 1.13e-01 -0.196000 0.71900
REACTOME FATTY ACYL COA BIOSYNTHESIS 11 2.64e-01 -0.195000 0.78400
REACTOME PERK REGULATED GENE EXPRESSION 22 1.15e-01 0.195000 0.71900
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 48 2.07e-02 0.193000 0.47900
REACTOME ACTIVATION OF GENES BY ATF4 19 1.48e-01 0.192000 0.71900
REACTOME SIGNALING BY ROBO RECEPTOR 19 1.56e-01 -0.188000 0.71900
REACTOME NEPHRIN INTERACTIONS 15 2.08e-01 0.188000 0.73000
REACTOME CHOLESTEROL BIOSYNTHESIS 12 2.63e-01 -0.187000 0.78400
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 2.86e-01 -0.186000 0.79900
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 17 1.87e-01 0.185000 0.71900
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 18 1.76e-01 0.184000 0.71900
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 21 1.55e-01 -0.179000 0.71900
REACTOME P38MAPK EVENTS 10 3.28e-01 -0.179000 0.82100
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 14 2.50e-01 -0.178000 0.78400
REACTOME PLATELET HOMEOSTASIS 32 8.30e-02 -0.177000 0.68200
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN 18 1.97e-01 0.176000 0.73000
REACTOME MYOGENESIS 21 1.64e-01 -0.176000 0.71900
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 15 2.41e-01 0.175000 0.78400
REACTOME GLYCOLYSIS 19 1.89e-01 -0.174000 0.71900
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 21 1.67e-01 0.174000 0.71900
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 18 2.02e-01 0.174000 0.73000
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 16 2.32e-01 0.173000 0.77700
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 48 4.03e-02 -0.171000 0.57800
REACTOME HS GAG DEGRADATION 11 3.30e-01 0.170000 0.82100
REACTOME PHASE II CONJUGATION 24 1.53e-01 0.169000 0.71900
REACTOME SIGNALLING TO RAS 20 1.92e-01 -0.168000 0.72400
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 11 3.36e-01 0.168000 0.83200
REACTOME CHROMOSOME MAINTENANCE 34 9.27e-02 -0.167000 0.70400
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS 24 1.58e-01 0.167000 0.71900
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 88 7.55e-03 -0.165000 0.47900
REACTOME METABOLISM OF POLYAMINES 12 3.23e-01 0.165000 0.82100
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 85 9.40e-03 -0.163000 0.47900
REACTOME G PROTEIN ACTIVATION 10 3.71e-01 -0.163000 0.85200
REACTOME BIOLOGICAL OXIDATIONS 39 8.17e-02 0.161000 0.68200
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 15 2.84e-01 -0.160000 0.79600
REACTOME SHC RELATED EVENTS 14 3.01e-01 -0.160000 0.81900
REACTOME INTERFERON ALPHA BETA SIGNALING 14 3.02e-01 -0.159000 0.81900
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 82 1.34e-02 -0.158000 0.47900
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 25 1.71e-01 -0.158000 0.71900
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 14 3.08e-01 -0.157000 0.82100
REACTOME VIRAL MESSENGER RNA SYNTHESIS 14 3.08e-01 -0.157000 0.82100
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS 11 3.68e-01 -0.157000 0.85200
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 22 2.04e-01 -0.156000 0.73000
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 11 3.69e-01 0.156000 0.85200
REACTOME SIGNALING BY NOTCH2 10 3.93e-01 -0.156000 0.85200
REACTOME CITRIC ACID CYCLE TCA CYCLE 19 2.40e-01 0.156000 0.78400
REACTOME LIPOPROTEIN METABOLISM 11 3.71e-01 -0.156000 0.85200
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 28 1.55e-01 0.156000 0.71900
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 11 3.72e-01 0.155000 0.85200
REACTOME PI 3K CASCADE 34 1.23e-01 0.153000 0.71900
REACTOME UNFOLDED PROTEIN RESPONSE 64 3.52e-02 0.153000 0.55100
REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT 19 2.54e-01 -0.151000 0.78400
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 10 4.10e-01 -0.151000 0.85200
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 18 2.74e-01 0.149000 0.78600
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 15 3.18e-01 0.149000 0.82100
REACTOME SHC MEDIATED CASCADE 10 4.15e-01 -0.149000 0.85200
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 24 2.08e-01 0.149000 0.73000
REACTOME INWARDLY RECTIFYING K CHANNELS 10 4.17e-01 -0.148000 0.85200
REACTOME L1CAM INTERACTIONS 51 6.90e-02 0.147000 0.67100
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 17 2.95e-01 0.147000 0.81200
REACTOME MRNA CAPPING 28 1.80e-01 -0.146000 0.71900
REACTOME GLUCOSE METABOLISM 44 9.43e-02 -0.146000 0.70400
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 11 4.02e-01 -0.146000 0.85200
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 96 1.46e-02 0.145000 0.47900
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 32 1.61e-01 0.143000 0.71900
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 36 1.39e-01 0.143000 0.71900
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 26 2.10e-01 0.142000 0.73000
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 16 3.27e-01 -0.142000 0.82100
REACTOME SPHINGOLIPID METABOLISM 35 1.47e-01 -0.142000 0.71900
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 26 2.18e-01 0.140000 0.74300
REACTOME PIP3 ACTIVATES AKT SIGNALING 25 2.27e-01 0.140000 0.76800
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 28 2.04e-01 0.139000 0.73000
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 11 4.26e-01 -0.139000 0.85200
REACTOME RNA POL III TRANSCRIPTION 31 1.82e-01 -0.139000 0.71900
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 10 4.54e-01 -0.137000 0.85800
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 57 7.63e-02 -0.136000 0.68000
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 57 7.99e-02 -0.134000 0.68200
REACTOME PI3K CASCADE 45 1.22e-01 0.133000 0.71900
REACTOME RAP1 SIGNALLING 12 4.26e-01 0.133000 0.85200
REACTOME CTLA4 INHIBITORY SIGNALING 15 3.75e-01 -0.132000 0.85200
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 14 3.96e-01 -0.131000 0.85200
REACTOME DARPP 32 EVENTS 17 3.54e-01 -0.130000 0.85200
REACTOME PYRIMIDINE METABOLISM 10 4.80e-01 -0.129000 0.86100
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 54 1.01e-01 -0.129000 0.71900
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 38 1.70e-01 0.129000 0.71900
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 84 4.36e-02 -0.128000 0.57800
REACTOME PPARA ACTIVATES GENE EXPRESSION 81 4.86e-02 0.127000 0.57800
REACTOME GLYCOSAMINOGLYCAN METABOLISM 49 1.32e-01 0.125000 0.71900
REACTOME COSTIMULATION BY THE CD28 FAMILY 33 2.17e-01 -0.124000 0.74300
REACTOME PKB MEDIATED EVENTS 27 2.67e-01 0.124000 0.78600
REACTOME SIGNAL ATTENUATION 10 5.00e-01 0.123000 0.86100
REACTOME DEADENYLATION OF MRNA 16 3.94e-01 -0.123000 0.85200
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 21 3.30e-01 -0.123000 0.82100
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 29 2.54e-01 0.122000 0.78400
REACTOME TRANSLATION 123 1.97e-02 -0.122000 0.47900
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 172 6.66e-03 0.121000 0.47900
REACTOME PI3K AKT ACTIVATION 31 2.46e-01 0.120000 0.78400
REACTOME GPCR DOWNSTREAM SIGNALING 103 3.57e-02 0.120000 0.55100
REACTOME PRE NOTCH PROCESSING IN GOLGI 14 4.37e-01 0.120000 0.85600
REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX 28 2.73e-01 -0.120000 0.78600
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 5.13e-01 0.119000 0.86400
REACTOME FRS2 MEDIATED CASCADE 16 4.17e-01 -0.117000 0.85200
REACTOME CALNEXIN CALRETICULIN CYCLE 11 5.02e-01 0.117000 0.86100
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 12 4.84e-01 -0.117000 0.86100
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 20 3.67e-01 0.117000 0.85200
REACTOME G ALPHA1213 SIGNALLING EVENTS 42 1.98e-01 0.115000 0.73000
REACTOME PEROXISOMAL LIPID METABOLISM 16 4.27e-01 0.115000 0.85200
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 12 4.91e-01 -0.115000 0.86100
REACTOME ARMS MEDIATED ACTIVATION 14 4.61e-01 -0.114000 0.85800
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 10 5.35e-01 -0.113000 0.87800
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 17 4.24e-01 -0.112000 0.85200
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 16 4.42e-01 -0.111000 0.85600
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 42 2.15e-01 0.111000 0.74300
REACTOME REGULATION OF MITOTIC CELL CYCLE 61 1.41e-01 -0.109000 0.71900
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 61 1.43e-01 0.109000 0.71900
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 17 4.39e-01 -0.108000 0.85600
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 19 4.16e-01 0.108000 0.85200
REACTOME CELL JUNCTION ORGANIZATION 30 3.08e-01 -0.108000 0.82100
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 52 1.84e-01 -0.107000 0.71900
REACTOME SIGNALING BY BMP 17 4.48e-01 0.106000 0.85600
REACTOME APOPTOTIC EXECUTION PHASE 27 3.40e-01 0.106000 0.83700
REACTOME CIRCADIAN CLOCK 42 2.38e-01 0.105000 0.78400
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING 19 4.31e-01 0.104000 0.85200
REACTOME CELL CYCLE CHECKPOINTS 78 1.13e-01 -0.104000 0.71900
REACTOME CA DEPENDENT EVENTS 14 5.04e-01 -0.103000 0.86100
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 34 3.01e-01 -0.103000 0.81900
REACTOME IL1 SIGNALING 23 3.95e-01 -0.102000 0.85200
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 19 4.40e-01 -0.102000 0.85600
REACTOME G2 M CHECKPOINTS 17 4.66e-01 -0.102000 0.85800
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 44 2.44e-01 0.102000 0.78400
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 15 5.04e-01 0.099600 0.86100
REACTOME PROTEIN FOLDING 40 2.80e-01 -0.098800 0.79100
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 127 5.69e-02 0.098200 0.59900
REACTOME TCR SIGNALING 28 3.75e-01 -0.096900 0.85200
REACTOME SIGNALING BY WNT 57 2.08e-01 -0.096600 0.73000
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 17 4.91e-01 0.096500 0.86100
REACTOME CELL CYCLE 212 1.65e-02 -0.096200 0.47900
REACTOME SIGNAL TRANSDUCTION BY L1 28 3.80e-01 0.095900 0.85200
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 36 3.24e-01 0.095200 0.82100
REACTOME BASE EXCISION REPAIR 12 5.70e-01 -0.094700 0.88200
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 13 5.56e-01 0.094400 0.88200
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 51 2.45e-01 0.094200 0.78400
REACTOME TRIF MEDIATED TLR3 SIGNALING 53 2.39e-01 0.093600 0.78400
REACTOME SIGNALING BY INSULIN RECEPTOR 73 1.71e-01 0.092900 0.71900
REACTOME METABOLISM OF NUCLEOTIDES 48 2.74e-01 0.091400 0.78600
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 20 4.84e-01 -0.090500 0.86100
REACTOME GPCR LIGAND BINDING 39 3.29e-01 -0.090500 0.82100
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 13 5.75e-01 0.089900 0.88200
REACTOME POTASSIUM CHANNELS 22 4.67e-01 -0.089700 0.85800
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 37 3.46e-01 0.089600 0.84800
REACTOME GAB1 SIGNALOSOME 32 3.83e-01 0.089300 0.85200
REACTOME NOD1 2 SIGNALING PATHWAY 17 5.26e-01 -0.088900 0.86700
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 27 4.28e-01 0.088300 0.85200
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 18 5.18e-01 0.088100 0.86400
REACTOME MTORC1 MEDIATED SIGNALLING 11 6.17e-01 0.087200 0.88800
REACTOME MITOTIC PROMETAPHASE 43 3.30e-01 -0.086000 0.82100
REACTOME METABOLISM OF PROTEINS 300 1.19e-02 -0.085200 0.47900
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 16 5.62e-01 -0.083800 0.88200
REACTOME DIABETES PATHWAYS 91 1.69e-01 0.083700 0.71900
REACTOME TRIGLYCERIDE BIOSYNTHESIS 21 5.12e-01 -0.082600 0.86400
REACTOME SIGNALING BY RHO GTPASES 62 2.63e-01 -0.082400 0.78400
REACTOME IL 2 SIGNALING 25 4.77e-01 -0.082300 0.86100
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 37 3.87e-01 0.082300 0.85200
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 51 3.12e-01 0.081900 0.82100
REACTOME DAG AND IP3 SIGNALING 16 5.74e-01 -0.081200 0.88200
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 11 6.41e-01 0.081200 0.90800
REACTOME NUCLEAR SIGNALING BY ERBB4 21 5.22e-01 0.080700 0.86400
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA 13 6.17e-01 0.080100 0.88800
REACTOME GABA RECEPTOR ACTIVATION 15 5.92e-01 0.080000 0.88200
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX 10 6.64e-01 -0.079400 0.92300
REACTOME DESTABILIZATION OF MRNA BY BRF1 16 5.83e-01 0.079300 0.88200
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 12 6.35e-01 0.079300 0.90100
REACTOME METABOLISM OF MRNA 176 7.14e-02 -0.079200 0.67100
REACTOME G ALPHA I SIGNALLING EVENTS 28 4.71e-01 0.078700 0.86100
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 11 6.54e-01 -0.078200 0.91600
REACTOME MITOTIC M M G1 PHASES 96 1.89e-01 -0.077900 0.71900
REACTOME INSULIN SYNTHESIS AND PROCESSING 13 6.30e-01 0.077200 0.89800
REACTOME SMOOTH MUSCLE CONTRACTION 18 5.71e-01 0.077200 0.88200
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 21 5.41e-01 0.077200 0.88200
REACTOME TRNA AMINOACYLATION 39 4.09e-01 -0.076600 0.85200
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 46 3.71e-01 -0.076300 0.85200
REACTOME CELL CYCLE MITOTIC 188 7.36e-02 -0.076100 0.67100
REACTOME PLC BETA MEDIATED EVENTS 20 5.59e-01 -0.075600 0.88200
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 17 5.92e-01 -0.075200 0.88200
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 17 5.92e-01 -0.075200 0.88200
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 38 4.26e-01 0.074800 0.85200
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 43 3.98e-01 -0.074600 0.85200
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 12 6.55e-01 0.074500 0.91600
REACTOME PURINE METABOLISM 27 5.04e-01 0.074300 0.86100
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 35 4.57e-01 -0.072700 0.85800
REACTOME ER PHAGOSOME PATHWAY 49 3.87e-01 -0.071600 0.85200
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 22 5.65e-01 0.070900 0.88200
REACTOME AQUAPORIN MEDIATED TRANSPORT 21 5.75e-01 -0.070800 0.88200
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 21 5.75e-01 -0.070800 0.88200
REACTOME OPIOID SIGNALLING 39 4.45e-01 -0.070700 0.85600
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 55 3.67e-01 0.070500 0.85200
REACTOME ELONGATION ARREST AND RECOVERY 24 5.53e-01 -0.070000 0.88200
REACTOME PI METABOLISM 37 4.62e-01 0.070000 0.85800
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 41 4.42e-01 0.069500 0.85600
REACTOME CD28 CO STIMULATION 21 5.84e-01 0.069100 0.88200
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 21 5.87e-01 0.068400 0.88200
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 12 6.84e-01 -0.068000 0.92900
REACTOME MEIOTIC RECOMBINATION 10 7.10e-01 -0.067900 0.92900
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 22 5.81e-01 0.067900 0.88200
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 98 2.55e-01 -0.066800 0.78400
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 20 6.06e-01 -0.066700 0.88500
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 37 4.85e-01 -0.066400 0.86100
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 13 6.79e-01 -0.066200 0.92900
REACTOME SIGNALING BY NOTCH1 50 4.25e-01 -0.065300 0.85200
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 125 2.09e-01 0.065300 0.73000
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 49 4.31e-01 -0.065200 0.85200
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 57 3.96e-01 -0.065200 0.85200
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 44 4.56e-01 -0.065100 0.85800
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 139 1.89e-01 -0.064900 0.71900
REACTOME G ALPHA Z SIGNALLING EVENTS 21 6.09e-01 -0.064600 0.88500
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 43 4.64e-01 0.064600 0.85800
REACTOME SIGNALING BY NODAL 11 7.12e-01 -0.064400 0.92900
REACTOME SIGNALING BY NOTCH4 10 7.28e-01 -0.063600 0.92900
REACTOME MITOTIC G1 G1 S PHASES 84 3.18e-01 -0.063100 0.82100
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 107 2.64e-01 0.062700 0.78400
REACTOME INFLUENZA LIFE CYCLE 113 2.57e-01 -0.062000 0.78400
REACTOME MICRORNA MIRNA BIOGENESIS 18 6.50e-01 -0.061900 0.91400
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 187 1.49e-01 -0.061600 0.71900
REACTOME SIGNALING BY ILS 61 4.07e-01 -0.061500 0.85200
REACTOME RNA POL I TRANSCRIPTION INITIATION 23 6.10e-01 -0.061500 0.88500
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 65 3.93e-01 -0.061400 0.85200
REACTOME DOUBLE STRAND BREAK REPAIR 12 7.13e-01 0.061400 0.92900
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 56 4.29e-01 -0.061200 0.85200
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 17 6.64e-01 0.060900 0.92300
REACTOME SIGNALING BY FGFR MUTANTS 26 5.94e-01 -0.060400 0.88200
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 162 1.88e-01 -0.060300 0.71900
REACTOME METABOLISM OF NON CODING RNA 42 5.02e-01 0.059900 0.86100
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 17 6.72e-01 -0.059400 0.92700
REACTOME DNA STRAND ELONGATION 13 7.12e-01 0.059200 0.92900
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 41 5.16e-01 -0.058700 0.86400
REACTOME G ALPHA Q SIGNALLING EVENTS 40 5.22e-01 0.058600 0.86400
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 41 5.19e-01 -0.058300 0.86400
REACTOME G1 PHASE 25 6.18e-01 -0.057700 0.88800
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 16 6.90e-01 -0.057700 0.92900
REACTOME G PROTEIN BETA GAMMA SIGNALLING 12 7.30e-01 -0.057600 0.92900
REACTOME ADAPTIVE IMMUNE SYSTEM 332 7.96e-02 -0.056600 0.68200
REACTOME M G1 TRANSITION 52 4.81e-01 -0.056500 0.86100
REACTOME PROCESSING OF INTRONLESS PRE MRNAS 13 7.29e-01 0.055600 0.92900
REACTOME MRNA PROCESSING 138 2.63e-01 0.055400 0.78400
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 15 7.13e-01 -0.054900 0.92900
REACTOME PROLONGED ERK ACTIVATION EVENTS 16 7.05e-01 -0.054600 0.92900
REACTOME ACTIVATED TLR4 SIGNALLING 60 4.66e-01 0.054500 0.85800
REACTOME ADP SIGNALLING THROUGH P2RY1 11 7.55e-01 -0.054300 0.93900
REACTOME ERK MAPK TARGETS 18 6.91e-01 0.054200 0.92900
REACTOME METABOLISM OF VITAMINS AND COFACTORS 36 5.77e-01 0.053800 0.88200
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS 16 7.10e-01 -0.053600 0.92900
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 59 4.78e-01 0.053500 0.86100
REACTOME SIGNALING BY PDGF 85 3.97e-01 0.053300 0.85200
REACTOME GENERIC TRANSCRIPTION PATHWAY 135 2.93e-01 0.052700 0.81200
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS 15 7.25e-01 -0.052400 0.92900
REACTOME METABOLISM OF RNA 215 1.89e-01 -0.052300 0.71900
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 43 5.55e-01 -0.052100 0.88200
REACTOME SIGNALING BY ERBB4 66 4.65e-01 0.052100 0.85800
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 56 5.06e-01 0.051500 0.86100
REACTOME DEVELOPMENTAL BIOLOGY 241 1.74e-01 0.051300 0.71900
REACTOME SIGNALING BY SCF KIT 56 5.09e-01 0.051100 0.86300
REACTOME RNA POL II TRANSCRIPTION 84 4.22e-01 0.050900 0.85200
REACTOME EFFECTS OF PIP2 HYDROLYSIS 13 7.51e-01 0.050800 0.93900
REACTOME MHC CLASS II ANTIGEN PRESENTATION 59 5.04e-01 -0.050400 0.86100
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 23 6.76e-01 0.050300 0.92900
REACTOME MRNA SPLICING MINOR PATHWAY 38 5.93e-01 -0.050200 0.88200
REACTOME IL 3 5 AND GM CSF SIGNALING 24 6.72e-01 -0.049900 0.92700
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 43 5.73e-01 -0.049800 0.88200
REACTOME DNA REPLICATION 107 3.75e-01 -0.049800 0.85200
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 14 7.48e-01 0.049700 0.93800
REACTOME LYSOSOME VESICLE BIOGENESIS 17 7.27e-01 -0.048900 0.92900
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 6.92e-01 0.048800 0.92900
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 16 7.36e-01 0.048700 0.92900
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 15 7.47e-01 0.048200 0.93800
REACTOME AXON GUIDANCE 143 3.28e-01 0.047600 0.82100
REACTOME GABA B RECEPTOR ACTIVATION 14 7.62e-01 0.046800 0.94200
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 43 6.00e-01 -0.046300 0.88500
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 62 5.50e-01 -0.044000 0.88200
REACTOME G0 AND EARLY G1 11 8.01e-01 -0.043900 0.95200
REACTOME SIGNALING BY GPCR 144 3.68e-01 0.043700 0.85200
REACTOME RESPIRATORY ELECTRON TRANSPORT 59 5.72e-01 0.042600 0.88200
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 28 6.97e-01 0.042500 0.92900
REACTOME COMPLEMENT CASCADE 11 8.09e-01 -0.042100 0.95300
REACTOME GLUTATHIONE CONJUGATION 12 8.04e-01 -0.041400 0.95200
REACTOME GLOBAL GENOMIC NER GG NER 23 7.33e-01 0.041100 0.92900
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA 18 7.65e-01 -0.040800 0.94200
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 53 6.08e-01 -0.040800 0.88500
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 13 8.06e-01 0.039300 0.95200
REACTOME SIGNALLING TO ERKS 28 7.20e-01 -0.039100 0.92900
REACTOME METABOLISM OF CARBOHYDRATES 131 4.48e-01 0.038600 0.85600
REACTOME SYNTHESIS OF PA 11 8.25e-01 0.038400 0.95300
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 31 7.14e-01 0.038100 0.92900
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 10 8.36e-01 0.037800 0.95800
REACTOME G ALPHA S SIGNALLING EVENTS 28 7.36e-01 0.036800 0.92900
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 52 6.49e-01 0.036500 0.91400
REACTOME LATE PHASE OF HIV LIFE CYCLE 84 5.68e-01 0.036200 0.88200
REACTOME S PHASE 72 5.97e-01 -0.036200 0.88200
REACTOME MEIOSIS 25 7.57e-01 -0.035900 0.93900
REACTOME EGFR DOWNREGULATION 23 7.69e-01 0.035400 0.94200
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 17 8.02e-01 0.035200 0.95200
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 20 7.85e-01 -0.035200 0.94700
REACTOME TRANSCRIPTION 125 5.00e-01 0.035000 0.86100
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 43 6.94e-01 -0.034700 0.92900
REACTOME ORC1 REMOVAL FROM CHROMATIN 51 6.72e-01 -0.034400 0.92700
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 108 5.40e-01 -0.034300 0.88200
REACTOME G1 S TRANSITION 69 6.23e-01 -0.034300 0.89400
REACTOME TOLL RECEPTOR CASCADES 72 6.30e-01 0.032900 0.89800
REACTOME REGULATION OF SIGNALING BY CBL 13 8.39e-01 -0.032600 0.95900
REACTOME SIGNALLING BY NGF 153 4.91e-01 0.032400 0.86100
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 22 7.94e-01 0.032200 0.95200
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 106 5.70e-01 0.032000 0.88200
REACTOME RNA POL I TRANSCRIPTION 26 7.79e-01 -0.031900 0.94700
REACTOME RNA POL I TRANSCRIPTION TERMINATION 19 8.16e-01 -0.030900 0.95300
REACTOME MRNA SPLICING 99 5.97e-01 0.030900 0.88200
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 18 8.25e-01 0.030200 0.95300
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 101 6.07e-01 0.029700 0.88500
REACTOME IMMUNE SYSTEM 505 2.80e-01 -0.028600 0.79100
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 279 4.18e-01 0.028400 0.85200
REACTOME CELL CELL COMMUNICATION 54 7.21e-01 -0.028200 0.92900
REACTOME METABOLISM OF PORPHYRINS 11 8.78e-01 -0.026700 0.98300
REACTOME ENOS ACTIVATION AND REGULATION 12 8.73e-01 -0.026600 0.98300
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 47 7.55e-01 -0.026300 0.93900
REACTOME SIGNALING BY NOTCH 74 6.97e-01 -0.026300 0.92900
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 73 7.01e-01 0.026100 0.92900
REACTOME SULFUR AMINO ACID METABOLISM 18 8.53e-01 0.025300 0.97200
REACTOME SPRY REGULATION OF FGF SIGNALING 12 8.80e-01 0.025200 0.98300
REACTOME KERATAN SULFATE KERATIN METABOLISM 14 8.76e-01 -0.024000 0.98300
REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX 27 8.32e-01 -0.023600 0.95600
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 10 8.98e-01 -0.023500 0.98500
REACTOME IL RECEPTOR SHC SIGNALING 15 8.75e-01 0.023500 0.98300
REACTOME NEURONAL SYSTEM 90 7.02e-01 -0.023400 0.92900
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 31 8.25e-01 -0.022900 0.95300
REACTOME SIGNALING BY FGFR IN DISEASE 81 7.22e-01 -0.022900 0.92900
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 97 6.99e-01 -0.022800 0.92900
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 58 7.67e-01 0.022500 0.94200
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 16 8.81e-01 -0.021600 0.98300
REACTOME SIGNAL AMPLIFICATION 14 8.91e-01 -0.021200 0.98500
REACTOME ERKS ARE INACTIVATED 10 9.08e-01 -0.021000 0.98500
REACTOME MITOTIC G2 G2 M PHASES 49 8.01e-01 -0.020800 0.95200
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 12 9.01e-01 0.020700 0.98500
REACTOME SEMAPHORIN INTERACTIONS 42 8.20e-01 -0.020300 0.95300
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 71 7.69e-01 -0.020200 0.94200
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 44 8.21e-01 -0.019800 0.95300
REACTOME SIGNALING BY ERBB2 68 7.84e-01 0.019300 0.94700
REACTOME INTERFERON SIGNALING 76 7.79e-01 -0.018600 0.94700
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 73 7.87e-01 0.018300 0.94700
REACTOME PLATELET AGGREGATION PLUG FORMATION 18 8.94e-01 -0.018200 0.98500
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 14 9.07e-01 0.018000 0.98500
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 24 8.80e-01 -0.017800 0.98300
REACTOME HS GAG BIOSYNTHESIS 15 9.06e-01 -0.017500 0.98500
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 11 9.22e-01 0.017000 0.99000
REACTOME SYNTHESIS OF DNA 62 8.18e-01 -0.016900 0.95300
REACTOME MEMBRANE TRAFFICKING 92 7.84e-01 -0.016600 0.94700
REACTOME APOPTOSIS 97 7.84e-01 -0.016100 0.94700
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 11 9.32e-01 -0.015000 0.99400
REACTOME TRANSCRIPTION COUPLED NER TC NER 35 8.79e-01 -0.014900 0.98300
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 22 9.06e-01 -0.014600 0.98500
REACTOME MEIOTIC SYNAPSIS 15 9.23e-01 -0.014400 0.99000
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 36 8.85e-01 -0.014000 0.98400
REACTOME HOST INTERACTIONS OF HIV FACTORS 98 8.13e-01 -0.013900 0.95300
REACTOME SIGNALING BY FGFR1 MUTANTS 20 9.19e-01 -0.013100 0.99000
REACTOME TIE2 SIGNALING 13 9.36e-01 0.012900 0.99400
REACTOME HIV LIFE CYCLE 92 8.32e-01 0.012800 0.95600
REACTOME HIV INFECTION 155 8.05e-01 -0.011500 0.95200
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 43 8.97e-01 0.011500 0.98500
REACTOME SIGNALING BY EGFR IN CANCER 83 8.72e-01 -0.010300 0.98300
REACTOME DNA REPAIR 66 8.88e-01 0.010000 0.98500
REACTOME REGULATION OF APOPTOSIS 49 9.07e-01 0.009620 0.98500
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 51 9.18e-01 -0.008360 0.99000
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 14 9.57e-01 -0.008350 0.99500
REACTOME NUCLEOTIDE EXCISION REPAIR 38 9.34e-01 -0.007730 0.99400
REACTOME KERATAN SULFATE BIOSYNTHESIS 11 9.65e-01 0.007580 0.99500
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 48 9.28e-01 -0.007540 0.99200
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 10 9.70e-01 -0.006900 0.99500
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 10 9.75e-01 0.005820 0.99500
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 51 9.44e-01 -0.005750 0.99400
REACTOME DOWNSTREAM TCR SIGNALING 20 9.65e-01 0.005700 0.99500
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 32 9.56e-01 -0.005640 0.99500
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 49 9.46e-01 -0.005590 0.99400
REACTOME INTEGRATION OF ENERGY METABOLISM 62 9.41e-01 -0.005480 0.99400
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 19 9.68e-01 -0.005300 0.99500
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 60 9.44e-01 0.005260 0.99400
REACTOME NETRIN1 SIGNALING 21 9.72e-01 -0.004450 0.99500
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 10 9.81e-01 -0.004440 0.99500
REACTOME HEMOSTASIS 212 9.15e-01 -0.004290 0.99000
REACTOME DESTABILIZATION OF MRNA BY KSRP 14 9.81e-01 0.003610 0.99500
REACTOME INNATE IMMUNE SYSTEM 118 9.47e-01 -0.003560 0.99400
REACTOME PHOSPHOLIPID METABOLISM 114 9.58e-01 0.002890 0.99500
REACTOME REGULATION OF INSULIN SECRETION 39 9.77e-01 0.002620 0.99500
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 82 9.68e-01 0.002600 0.99500
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 46 9.77e-01 -0.002480 0.99500
REACTOME MITOCHONDRIAL PROTEIN IMPORT 42 9.82e-01 0.002020 0.99500
REACTOME SIGNALING BY FGFR 69 9.78e-01 0.001920 0.99500
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM 10 9.92e-01 0.001900 0.99600
REACTOME REGULATORY RNA PATHWAYS 21 9.89e-01 0.001710 0.99600
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 54 9.86e-01 -0.001360 0.99600
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 46 9.92e-01 0.000880 0.99600
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 15 9.97e-01 0.000468 0.99700
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 38 9.97e-01 0.000364 0.99700


Detailed Gene set reports



REACTOME_SIGNALING_BY_HIPPO

REACTOME_SIGNALING_BY_HIPPO
64
set REACTOME_SIGNALING_BY_HIPPO
setSize 15
pANOVA 1.69e-05
s.dist -0.642
p.adjustANOVA 0.00782



Top enriched genes

Top 20 genes
GeneID Gene Rank
Wwtr1 -4630
Sav1 -4500
Stk4 -4357
Ywhae -4285
Tjp1 -4199
Yap1 -3939
Amot -3920
Amotl1 -3657
Dvl2 -3016
Mob1a -2343
Lats2 -2305
Ywhab -2122
Amotl2 -1740
Mob1b -1639
Lats1 1658

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Wwtr1 -4630
Sav1 -4500
Stk4 -4357
Ywhae -4285
Tjp1 -4199
Yap1 -3939
Amot -3920
Amotl1 -3657
Dvl2 -3016
Mob1a -2343
Lats2 -2305
Ywhab -2122
Amotl2 -1740
Mob1b -1639
Lats1 1658


REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA

REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA
233
set REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA
setSize 11
pANOVA 0.00548
s.dist 0.484
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsp90b1 4438
Hspa5 3835
Xbp1 3672
Atf4 2941
Atf6 2850
Ddit3 2719
Calr 1653
Mbtps2 1323
Nfya 1132
Mbtps1 202
Nfyb -389

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsp90b1 4438
Hspa5 3835
Xbp1 3672
Atf4 2941
Atf6 2850
Ddit3 2719
Calr 1653
Mbtps2 1323
Nfya 1132
Mbtps1 202
Nfyb -389


REACTOME_METAL_ION_SLC_TRANSPORTERS

REACTOME_METAL_ION_SLC_TRANSPORTERS
277
set REACTOME_METAL_ION_SLC_TRANSPORTERS
setSize 12
pANOVA 0.026
s.dist 0.371
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc39a10 4453
Slc30a1 3918
Slc30a5 3705
Slc31a1 3422
Slc30a7 3245
Slc40a1 3036
Cp 1805
Slc30a2 1479
Slc41a1 686
Slc39a7 -412
Slc39a3 -1860
Slc39a1 -3141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc39a10 4453
Slc30a1 3918
Slc30a5 3705
Slc31a1 3422
Slc30a7 3245
Slc40a1 3036
Cp 1805
Slc30a2 1479
Slc41a1 686
Slc39a7 -412
Slc39a3 -1860
Slc39a1 -3141


REACTOME_COLLAGEN_FORMATION

REACTOME_COLLAGEN_FORMATION
93
set REACTOME_COLLAGEN_FORMATION
setSize 26
pANOVA 0.00154
s.dist 0.359
p.adjustANOVA 0.356



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col14a1 4408
Col4a1 4400
Col4a2 4271
Serpinh1 4036
Bmp1 3743
Col22a1 3532
Col6a3 3465
Col5a2 3229
Adamts2 3072
Pcolce2 2989
Plod1 2820
Col6a1 2662
Col1a2 2630
Pcolce 2249
Col1a1 2215
Col15a1 2011
Col6a2 835
Col3a1 559
Col5a1 489
P4hb 142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col14a1 4408
Col4a1 4400
Col4a2 4271
Serpinh1 4036
Bmp1 3743
Col22a1 3532
Col6a3 3465
Col5a2 3229
Adamts2 3072
Pcolce2 2989
Plod1 2820
Col6a1 2662
Col1a2 2630
Pcolce 2249
Col1a1 2215
Col15a1 2011
Col6a2 835
Col3a1 559
Col5a1 489
P4hb 142
Col24a1 -24
Plod3 -845
Col7a1 -1521
Col5a3 -2261
Col11a2 -3099
Ppib -3485


REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS
255
set REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS
setSize 24
pANOVA 0.00384
s.dist 0.341
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc16a1 4517
Slc39a10 4453
Slc47a1 3930
Slc30a1 3918
Slc30a5 3705
Slc31a1 3422
Slc2a1 3316
Slc30a7 3245
Slc22a5 3151
Slc2a12 3089
Slc40a1 3036
Slc2a3 2598
Slc44a1 2570
Slc2a4 2484
Cp 1805
Slc30a2 1479
Slc41a1 686
Slc2a8 408
Slc39a7 -412
Slc39a3 -1860

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc16a1 4517
Slc39a10 4453
Slc47a1 3930
Slc30a1 3918
Slc30a5 3705
Slc31a1 3422
Slc2a1 3316
Slc30a7 3245
Slc22a5 3151
Slc2a12 3089
Slc40a1 3036
Slc2a3 2598
Slc44a1 2570
Slc2a4 2484
Cp 1805
Slc30a2 1479
Slc41a1 686
Slc2a8 408
Slc39a7 -412
Slc39a3 -1860
Slc16a3 -2003
Slc6a6 -2970
Slc39a1 -3141
Slc44a2 -4164


REACTOME_PHOSPHORYLATION_OF_THE_APC_C

REACTOME_PHOSPHORYLATION_OF_THE_APC_C
423
set REACTOME_PHOSPHORYLATION_OF_THE_APC_C
setSize 14
pANOVA 0.0273
s.dist -0.341
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Anapc1 1589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Anapc1 1589


REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS

REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
218
set REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS
setSize 11
pANOVA 0.0516
s.dist 0.339
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adss 4549
Pfas 4377
Gmps 4008
Atic 3425
Gart 2839
Adssl1 2072
Impdh2 1883
Adsl -780
Impdh1 -1126
Paics -1444
Ppat -2805

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adss 4549
Pfas 4377
Gmps 4008
Atic 3425
Gart 2839
Adssl1 2072
Impdh2 1883
Adsl -780
Impdh1 -1126
Paics -1444
Ppat -2805


REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS

REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS
4
set REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS
setSize 15
pANOVA 0.0238
s.dist -0.337
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Bub3 -1354
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Anapc1 1589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Bub3 -1354
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Anapc1 1589


REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS

REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
123
set REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS
setSize 14
pANOVA 0.029
s.dist 0.337
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sdc4 4435
Hspg2 4409
Agrn 4163
Dcn 4047
B3gat3 3450
Bgn 3343
Cspg4 2975
Sdc2 2440
Vcan 2439
Gxylt1 53
B4galt7 -717
Gpc1 -2236
Sdc3 -3105
Gpc4 -4196

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sdc4 4435
Hspg2 4409
Agrn 4163
Dcn 4047
B3gat3 3450
Bgn 3343
Cspg4 2975
Sdc2 2440
Vcan 2439
Gxylt1 53
B4galt7 -717
Gpc1 -2236
Sdc3 -3105
Gpc4 -4196


REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
228
set REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS
setSize 16
pANOVA 0.0259
s.dist -0.322
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Grip2 -4365
Ap2a1 -3575
Epb41l1 -3392
Ap2a2 -3067
Camk2a -2747
Myo6 -2039
Ap2s1 -1987
Pick1 -1927
Prkca -1839
Mdm2 -1552
Camk2b -1409
Nsf -1351
Ap2b1 45
Dlg1 446
Camk2d 594
Ap2m1 3890

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grip2 -4365
Ap2a1 -3575
Epb41l1 -3392
Ap2a2 -3067
Camk2a -2747
Myo6 -2039
Ap2s1 -1987
Pick1 -1927
Prkca -1839
Mdm2 -1552
Camk2b -1409
Nsf -1351
Ap2b1 45
Dlg1 446
Camk2d 594
Ap2m1 3890


REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION

REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
350
set REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
setSize 13
pANOVA 0.0469
s.dist 0.318
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nfkbia 4436
Mavs 3995
Chuk 3834
Ikbkg 3350
Rela 2283
Traf6 1789
Traf2 1484
App 1176
Map3k1 595
Nfkb2 42
Nfkbib -676
Trim25 -704
Ikbkb -2767

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nfkbia 4436
Mavs 3995
Chuk 3834
Ikbkg 3350
Rela 2283
Traf6 1789
Traf2 1484
App 1176
Map3k1 595
Nfkb2 42
Nfkbib -676
Trim25 -704
Ikbkb -2767


REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN

REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN
98
set REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN
setSize 11
pANOVA 0.0702
s.dist -0.315
p.adjustANOVA 0.671



Top enriched genes

Top 20 genes
GeneID Gene Rank
Map2k2 -4371
Hras -4011
Map2k1 -3355
Nras -2241
Ywhab -2122
Raf1 -1481
Rit1 -596
Kras -455
Braf -384
Mapk1 642
Mapk3 2002

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Map2k2 -4371
Hras -4011
Map2k1 -3355
Nras -2241
Ywhab -2122
Raf1 -1481
Rit1 -596
Kras -455
Braf -384
Mapk1 642
Mapk3 2002


REACTOME_STRIATED_MUSCLE_CONTRACTION

REACTOME_STRIATED_MUSCLE_CONTRACTION
208
set REACTOME_STRIATED_MUSCLE_CONTRACTION
setSize 22
pANOVA 0.0109
s.dist 0.314
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Vim 4225
Neb 4201
Dmd 3799
Actn2 3554
Tpm4 3505
Des 3053
Myl2 2965
Mybpc1 2887
Mybpc2 2710
Myl3 2447
Tpm3 2275
Tcap 1644
Tnni1 1246
Tpm2 904
Tnnt1 657
Tnnc1 373
Tmod1 44
Myl1 -204
Myl4 -233
Tnni2 -2281

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Vim 4225
Neb 4201
Dmd 3799
Actn2 3554
Tpm4 3505
Des 3053
Myl2 2965
Mybpc1 2887
Mybpc2 2710
Myl3 2447
Tpm3 2275
Tcap 1644
Tnni1 1246
Tpm2 904
Tnnt1 657
Tnnc1 373
Tmod1 44
Myl1 -204
Myl4 -233
Tnni2 -2281
Tpm1 -3168
Tnnc2 -3223


REACTOME_GLUCONEOGENESIS

REACTOME_GLUCONEOGENESIS
173
set REACTOME_GLUCONEOGENESIS
setSize 19
pANOVA 0.0189
s.dist -0.311
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prkacb -4346
Pck1 -4330
Eno1 -3838
Pcx -3834
Pgam2 -3622
Prkaca -3012
Tpi1 -2993
Pgam1 -2806
Slc25a11 -2625
Pgk1 -2452
Mdh2 -1805
Eno3 -1176
Fbp2 -987
Pfkfb1 -181
Slc25a12 -175
Gpi1 880
Mdh1 2261
Got2 3060
Got1 4082

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prkacb -4346
Pck1 -4330
Eno1 -3838
Pcx -3834
Pgam2 -3622
Prkaca -3012
Tpi1 -2993
Pgam1 -2806
Slc25a11 -2625
Pgk1 -2452
Mdh2 -1805
Eno3 -1176
Fbp2 -987
Pfkfb1 -181
Slc25a12 -175
Gpi1 880
Mdh1 2261
Got2 3060
Got1 4082


REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING

REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING
139
set REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING
setSize 14
pANOVA 0.0524
s.dist -0.3
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Egf -4654
Map2k2 -4371
Hras -4011
Map2k1 -3355
Shc1 -3332
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Egfr 3356

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Egf -4654
Map2k2 -4371
Hras -4011
Map2k1 -3355
Shc1 -3332
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Egfr 3356


REACTOME_CELL_CELL_JUNCTION_ORGANIZATION

REACTOME_CELL_CELL_JUNCTION_ORGANIZATION
258
set REACTOME_CELL_CELL_JUNCTION_ORGANIZATION
setSize 15
pANOVA 0.0494
s.dist -0.293
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdh5 -4162
F11r -4079
Cdh4 -4020
Ctnna1 -3948
Cldn5 -3410
Pvr -3089
Pard6a -2715
Jup -2480
Cdh13 -2106
Cadm1 -1663
Cdh15 -18
Ctnnb1 596
Prkci 2539
Pard3 3424
Cldn12 4352

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdh5 -4162
F11r -4079
Cdh4 -4020
Ctnna1 -3948
Cldn5 -3410
Pvr -3089
Pard6a -2715
Jup -2480
Cdh13 -2106
Cadm1 -1663
Cdh15 -18
Ctnnb1 596
Prkci 2539
Pard3 3424
Cldn12 4352


REACTOME_INSULIN_RECEPTOR_RECYCLING

REACTOME_INSULIN_RECEPTOR_RECYCLING
18
set REACTOME_INSULIN_RECEPTOR_RECYCLING
setSize 15
pANOVA 0.0507
s.dist 0.292
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp6v1b2 4551
Atp6v1h 4146
Atp6v0d1 4100
Atp6v1a 3767
Insr 3555
Atp6v1f 2578
Atp6v1c1 2260
Atp6v0e 1497
Atp6v0b 1119
Atp6v1e1 666
Atp6v1g1 588
Tcirg1 -2005
Atp6v1d -2165
Atp6v0a2 -2392
Atp6v0c -2397

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp6v1b2 4551
Atp6v1h 4146
Atp6v0d1 4100
Atp6v1a 3767
Insr 3555
Atp6v1f 2578
Atp6v1c1 2260
Atp6v0e 1497
Atp6v0b 1119
Atp6v1e1 666
Atp6v1g1 588
Tcirg1 -2005
Atp6v1d -2165
Atp6v0a2 -2392
Atp6v0c -2397


REACTOME_BOTULINUM_NEUROTOXICITY

REACTOME_BOTULINUM_NEUROTOXICITY
39
set REACTOME_BOTULINUM_NEUROTOXICITY
setSize 10
pANOVA 0.117
s.dist 0.286
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Stx12 3752
Stx2 3412
Stx8 3261
Stx5a 3227
Vamp2 2756
Stx3 2366
Vamp1 -162
Stx7 -507
Stx4a -536
Stx6 -4564

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Stx12 3752
Stx2 3412
Stx8 3261
Stx5a 3227
Vamp2 2756
Stx3 2366
Vamp1 -162
Stx7 -507
Stx4a -536
Stx6 -4564


REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS

REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS
42
set REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS
setSize 10
pANOVA 0.117
s.dist 0.286
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Stx12 3752
Stx2 3412
Stx8 3261
Stx5a 3227
Vamp2 2756
Stx3 2366
Vamp1 -162
Stx7 -507
Stx4a -536
Stx6 -4564

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Stx12 3752
Stx2 3412
Stx8 3261
Stx5a 3227
Vamp2 2756
Stx3 2366
Vamp1 -162
Stx7 -507
Stx4a -536
Stx6 -4564


REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM
114
set REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM
setSize 22
pANOVA 0.0205
s.dist 0.286
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sdc4 4435
Hspg2 4409
Idua 4368
Agrn 4163
Dcn 4047
B3gat3 3450
Bgn 3343
Csgalnact2 3130
Cspg4 2975
Ids 2493
Sdc2 2440
Vcan 2439
Hexa 1683
Dse 339
Arsb 55
Gxylt1 53
B4galt7 -717
Chpf2 -1043
Gpc1 -2236
Sdc3 -3105

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sdc4 4435
Hspg2 4409
Idua 4368
Agrn 4163
Dcn 4047
B3gat3 3450
Bgn 3343
Csgalnact2 3130
Cspg4 2975
Ids 2493
Sdc2 2440
Vcan 2439
Hexa 1683
Dse 339
Arsb 55
Gxylt1 53
B4galt7 -717
Chpf2 -1043
Gpc1 -2236
Sdc3 -3105
Hexb -4023
Gpc4 -4196


REACTOME_NCAM1_INTERACTIONS

REACTOME_NCAM1_INTERACTIONS
229
set REACTOME_NCAM1_INTERACTIONS
setSize 17
pANOVA 0.0443
s.dist 0.282
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col4a1 4400
Col4a2 4271
Agrn 4163
Col6a3 3465
Col5a2 3229
Cacna1s 2789
Col6a1 2662
Col1a2 2630
Col1a1 2215
Col6a2 835
Col3a1 559
Col5a1 489
Prnp -351
St8sia4 -551
Gfra1 -640
Nrtn -3759
Cacnb1 -4652

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col4a1 4400
Col4a2 4271
Agrn 4163
Col6a3 3465
Col5a2 3229
Cacna1s 2789
Col6a1 2662
Col1a2 2630
Col1a1 2215
Col6a2 835
Col3a1 559
Col5a1 489
Prnp -351
St8sia4 -551
Gfra1 -640
Nrtn -3759
Cacnb1 -4652


REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A

REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A
447
set REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A
setSize 17
pANOVA 0.0463
s.dist -0.279
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Bub3 -1354
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Rps27a 648
Uba52 741
Anapc1 1589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Bub3 -1354
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Rps27a 648
Uba52 741
Anapc1 1589


REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B

REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B
415
set REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B
setSize 16
pANOVA 0.0537
s.dist -0.279
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Rps27a 648
Uba52 741
Anapc1 1589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Rps27a 648
Uba52 741
Anapc1 1589


REACTOME_INTERFERON_GAMMA_SIGNALING

REACTOME_INTERFERON_GAMMA_SIGNALING
359
set REACTOME_INTERFERON_GAMMA_SIGNALING
setSize 21
pANOVA 0.0295
s.dist -0.275
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Irf8 -4528
H2-Aa -4521
H2-Eb1 -4489
Stat1 -4470
Irf1 -4184
Gbp7 -3971
Pias1 -3707
B2m -3340
Prkcd -3228
Ptpn2 -2929
Camk2a -2747
Camk2b -1409
Irf2 -728
Irf3 -726
Ifngr2 58
Camk2d 594
Sumo1 780
Ptpn1 3701
Jak1 3768
Ifngr1 4211

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf8 -4528
H2-Aa -4521
H2-Eb1 -4489
Stat1 -4470
Irf1 -4184
Gbp7 -3971
Pias1 -3707
B2m -3340
Prkcd -3228
Ptpn2 -2929
Camk2a -2747
Camk2b -1409
Irf2 -728
Irf3 -726
Ifngr2 58
Camk2d 594
Sumo1 780
Ptpn1 3701
Jak1 3768
Ifngr1 4211
Jak2 4611


REACTOME_SOS_MEDIATED_SIGNALLING

REACTOME_SOS_MEDIATED_SIGNALLING
386
set REACTOME_SOS_MEDIATED_SIGNALLING
setSize 13
pANOVA 0.0909
s.dist -0.271
p.adjustANOVA 0.702



Top enriched genes

Top 20 genes
GeneID Gene Rank
Irs1 -4551
Map2k2 -4371
Hras -4011
Map2k1 -3355
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Irs2 3057

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irs1 -4551
Map2k2 -4371
Hras -4011
Map2k1 -3355
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Irs2 3057


REACTOME_GLUCOSE_TRANSPORT

REACTOME_GLUCOSE_TRANSPORT
290
set REACTOME_GLUCOSE_TRANSPORT
setSize 29
pANOVA 0.0123
s.dist 0.269
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hk2 4610
Gck 4382
Nupl2 4334
Ranbp2 3601
Nup133 3358
Slc2a1 3316
Slc2a3 2598
Pom121 2492
Slc2a4 2484
Nup210 2445
Nup35 2353
Tpr 2262
Nup153 2199
Nup188 2136
Nup85 1681
Nup54 1654
Nup93 1084
Nup214 845
Nup62 609
Nup88 561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hk2 4610
Gck 4382
Nupl2 4334
Ranbp2 3601
Nup133 3358
Slc2a1 3316
Slc2a3 2598
Pom121 2492
Slc2a4 2484
Nup210 2445
Nup35 2353
Tpr 2262
Nup153 2199
Nup188 2136
Nup85 1681
Nup54 1654
Nup93 1084
Nup214 845
Nup62 609
Nup88 561
G6pc3 488
Nup37 -73
Slc37a4 -546
Nup205 -1122
Rae1 -1401
Nup155 -1461
Nup107 -2500
Aaas -2952
Seh1l -4157


REACTOME_IRON_UPTAKE_AND_TRANSPORT

REACTOME_IRON_UPTAKE_AND_TRANSPORT
357
set REACTOME_IRON_UPTAKE_AND_TRANSPORT
setSize 23
pANOVA 0.0273
s.dist 0.266
p.adjustANOVA 0.5



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp6v1b2 4551
Hmox1 4445
Atp6v1h 4146
Atp6v0d1 4100
Ftl1 3915
Atp6v1a 3767
Tfrc 3374
Slc40a1 3036
Atp6v1f 2578
Atp6v1c1 2260
Cp 1805
Atp6v0e 1497
Hmox2 1139
Atp6v0b 1119
Atp6v1e1 666
Atp6v1g1 588
Fth1 -739
Tcirg1 -2005
Atp6v1d -2165
Atp6v0a2 -2392

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp6v1b2 4551
Hmox1 4445
Atp6v1h 4146
Atp6v0d1 4100
Ftl1 3915
Atp6v1a 3767
Tfrc 3374
Slc40a1 3036
Atp6v1f 2578
Atp6v1c1 2260
Cp 1805
Atp6v0e 1497
Hmox2 1139
Atp6v0b 1119
Atp6v1e1 666
Atp6v1g1 588
Fth1 -739
Tcirg1 -2005
Atp6v1d -2165
Atp6v0a2 -2392
Atp6v0c -2397
Steap3 -2706
Mcoln1 -2868


REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS

REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS
429
set REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS
setSize 11
pANOVA 0.132
s.dist -0.262
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Bcl2 -3541
Bcl2l11 -3138
Bad -2986
Tfdp1 -2874
Akt1 -2346
Ywhab -2122
Dynll2 -1682
Trp53 944
Ppp3r1 980
Mapk8 1538
Dynll1 1560

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bcl2 -3541
Bcl2l11 -3138
Bad -2986
Tfdp1 -2874
Akt1 -2346
Ywhab -2122
Dynll2 -1682
Trp53 944
Ppp3r1 980
Mapk8 1538
Dynll1 1560


REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION

REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
166
set REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION
setSize 13
pANOVA 0.103
s.dist 0.262
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pcca 3808
Acadl 3258
Acadvl 2932
Echs1 1829
Hadhb 1800
Hadha 1567
Decr1 1144
Eci1 1080
Acads 839
Mcee 428
Acadm 232
Pccb -501
Hadh -3003

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pcca 3808
Acadl 3258
Acadvl 2932
Echs1 1829
Hadhb 1800
Hadha 1567
Decr1 1144
Eci1 1080
Acads 839
Mcee 428
Acadm 232
Pccb -501
Hadh -3003


REACTOME_PURINE_SALVAGE

REACTOME_PURINE_SALVAGE
247
set REACTOME_PURINE_SALVAGE
setSize 10
pANOVA 0.154
s.dist -0.26
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gmpr -4553
Ampd2 -3119
Adal -2513
Aprt -1497
Hprt -1095
Dguok -1052
Adk -394
Pnp -105
Ampd1 298
Ampd3 1697

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gmpr -4553
Ampd2 -3119
Adal -2513
Aprt -1497
Hprt -1095
Dguok -1052
Adk -394
Pnp -105
Ampd1 298
Ampd3 1697


REACTOME_PLATELET_SENSITIZATION_BY_LDL

REACTOME_PLATELET_SENSITIZATION_BY_LDL
342
set REACTOME_PLATELET_SENSITIZATION_BY_LDL
setSize 11
pANOVA 0.136
s.dist -0.26
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp2r1a -4030
Ppp2r5e -3649
Ppp2r5a -3183
Ppp2r1b -3045
Ppp2r5b -2790
Mapk14 -1417
Ppp2cb -1138
Ppp2r5d -531
Ppp2r5c 476
Pecam1 1421
Ppp2ca 4336

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2r1a -4030
Ppp2r5e -3649
Ppp2r5a -3183
Ppp2r1b -3045
Ppp2r5b -2790
Mapk14 -1417
Ppp2cb -1138
Ppp2r5d -531
Ppp2r5c 476
Pecam1 1421
Ppp2ca 4336


REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
75
set REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
setSize 31
pANOVA 0.0138
s.dist 0.256
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col14a1 4408
Col4a1 4400
Col4a2 4271
Serpinh1 4036
Bmp1 3743
Col22a1 3532
Col6a3 3465
Col5a2 3229
Adamts2 3072
Mmp14 3044
Pcolce2 2989
Plod1 2820
Col6a1 2662
Col1a2 2630
Pcolce 2249
Col1a1 2215
Col15a1 2011
Col6a2 835
Col3a1 559
Col5a1 489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col14a1 4408
Col4a1 4400
Col4a2 4271
Serpinh1 4036
Bmp1 3743
Col22a1 3532
Col6a3 3465
Col5a2 3229
Adamts2 3072
Mmp14 3044
Pcolce2 2989
Plod1 2820
Col6a1 2662
Col1a2 2630
Pcolce 2249
Col1a1 2215
Col15a1 2011
Col6a2 835
Col3a1 559
Col5a1 489
P4hb 142
Col24a1 -24
Timp2 -160
Plod3 -845
Col7a1 -1521
Col5a3 -2261
Mmp2 -2414
Col11a2 -3099
Mmp15 -3419
Ppib -3485
Furin -3720


REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE

REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE
420
set REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE
setSize 15
pANOVA 0.0893
s.dist -0.253
p.adjustANOVA 0.702



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Anapc1 1589
Cdc14a 4462

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc23 -4083
Ube2d1 -4028
Anapc4 -3858
Anapc11 -2867
Anapc2 -2138
Ube2e1 -2058
Cdc27 -2046
Cdc26 -2021
Anapc7 -1228
Anapc5 -1141
Anapc10 318
Ube2c 495
Cdc16 589
Anapc1 1589
Cdc14a 4462


REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
134
set REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX
setSize 11
pANOVA 0.147
s.dist 0.253
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pdp2 4364
Pdk4 4237
Pdpr 3427
Pdhb 3061
Dld 2769
Pdha1 1724
Pdk1 -57
Pdhx -78
Pdk2 -773
Dlat -1594
Pdp1 -4478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pdp2 4364
Pdk4 4237
Pdpr 3427
Pdhb 3061
Dld 2769
Pdha1 1724
Pdk1 -57
Pdhx -78
Pdk2 -773
Dlat -1594
Pdp1 -4478


REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION

REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
176
set REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION
setSize 20
pANOVA 0.0511
s.dist -0.252
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Lars2 -4364
Dars2 -4208
Yars2 -3957
Nars2 -3846
Aars2 -3762
Rars2 -3680
Qars -3310
Fars2 -2332
Cars2 -1904
Vars2 -1893
Gars -1793
Ppa2 -1255
Ears2 -1154
Kars 437
Iars2 913
Sars2 1563
Tars2 1632
Hars2 2680
Mars2 2964
Wars2 3384

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lars2 -4364
Dars2 -4208
Yars2 -3957
Nars2 -3846
Aars2 -3762
Rars2 -3680
Qars -3310
Fars2 -2332
Cars2 -1904
Vars2 -1893
Gars -1793
Ppa2 -1255
Ears2 -1154
Kars 437
Iars2 913
Sars2 1563
Tars2 1632
Hars2 2680
Mars2 2964
Wars2 3384


REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE

REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE
17
set REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE
setSize 14
pANOVA 0.106
s.dist -0.25
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp2r1a -4030
Ppp2r5e -3649
Ppp2r5a -3183
Ppp2r1b -3045
Ppp2r5b -2790
Axin1 -2755
Frat2 -2744
Ppp2cb -1138
Ppp2r5d -531
Ppp2r5c 476
Ctnnb1 596
Csnk1a1 937
Apc 954
Ppp2ca 4336

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2r1a -4030
Ppp2r5e -3649
Ppp2r5a -3183
Ppp2r1b -3045
Ppp2r5b -2790
Axin1 -2755
Frat2 -2744
Ppp2cb -1138
Ppp2r5d -531
Ppp2r5c 476
Ctnnb1 596
Csnk1a1 937
Apc 954
Ppp2ca 4336


REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION

REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION
399
set REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION
setSize 18
pANOVA 0.0676
s.dist -0.249
p.adjustANOVA 0.671



Top enriched genes

Top 20 genes
GeneID Gene Rank
Polr2l -4476
Polr2f -3986
Polr2k -3307
Polr3gl -3131
Nfib -3103
Polr1d -2858
Polr3k -2641
Polr2h -2074
Polr3f -1634
Polr3a -1111
Polr1c -696
Polr3d -609
Polr3c -377
Polr2e 176
Ssb 394
Polr3h 1236
Polr3b 3064
Polr3e 3896

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Polr2l -4476
Polr2f -3986
Polr2k -3307
Polr3gl -3131
Nfib -3103
Polr1d -2858
Polr3k -2641
Polr2h -2074
Polr3f -1634
Polr3a -1111
Polr1c -696
Polr3d -609
Polr3c -377
Polr2e 176
Ssb 394
Polr3h 1236
Polr3b 3064
Polr3e 3896


REACTOME_RNA_POL_III_CHAIN_ELONGATION

REACTOME_RNA_POL_III_CHAIN_ELONGATION
431
set REACTOME_RNA_POL_III_CHAIN_ELONGATION
setSize 16
pANOVA 0.0909
s.dist -0.244
p.adjustANOVA 0.702



Top enriched genes

Top 20 genes
GeneID Gene Rank
Polr2l -4476
Polr2f -3986
Polr2k -3307
Polr3gl -3131
Polr1d -2858
Polr3k -2641
Polr2h -2074
Polr3f -1634
Polr3a -1111
Polr1c -696
Polr3d -609
Polr3c -377
Polr2e 176
Polr3h 1236
Polr3b 3064
Polr3e 3896

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Polr2l -4476
Polr2f -3986
Polr2k -3307
Polr3gl -3131
Polr1d -2858
Polr3k -2641
Polr2h -2074
Polr3f -1634
Polr3a -1111
Polr1c -696
Polr3d -609
Polr3c -377
Polr2e 176
Polr3h 1236
Polr3b 3064
Polr3e 3896


REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS
47
set REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS
setSize 10
pANOVA 0.182
s.dist -0.244
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Galnt10 -4526
B4galt5 -4327
St3gal1 -3734
St3gal3 -2741
Galnt1 -1981
C1galt1c1 -173
C1galt1 259
St6galnac4 748
St3gal2 1729
Galnt11 3185

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Galnt10 -4526
B4galt5 -4327
St3gal1 -3734
St3gal3 -2741
Galnt1 -1981
C1galt1c1 -173
C1galt1 259
St6galnac4 748
St3gal2 1729
Galnt11 3185


REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS

REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS
115
set REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS
setSize 17
pANOVA 0.084
s.dist 0.242
p.adjustANOVA 0.682



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nos1 4590
Atp6v1b2 4551
Atp6v1h 4146
Atp6v0d1 4100
Atp6v1a 3767
Atp6v1f 2578
Atp6v1c1 2260
Atp6v0e 1497
Nos3 1399
Atp6v0b 1119
Atp6v1e1 666
Atp6v1g1 588
Tcirg1 -2005
Atp6v1d -2165
Atp6v0a2 -2392
Atp6v0c -2397
Cyba -3679

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nos1 4590
Atp6v1b2 4551
Atp6v1h 4146
Atp6v0d1 4100
Atp6v1a 3767
Atp6v1f 2578
Atp6v1c1 2260
Atp6v0e 1497
Nos3 1399
Atp6v0b 1119
Atp6v1e1 666
Atp6v1g1 588
Tcirg1 -2005
Atp6v1d -2165
Atp6v0a2 -2392
Atp6v0c -2397
Cyba -3679


REACTOME_SHC_MEDIATED_SIGNALLING

REACTOME_SHC_MEDIATED_SIGNALLING
404
set REACTOME_SHC_MEDIATED_SIGNALLING
setSize 13
pANOVA 0.148
s.dist -0.232
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Map2k2 -4371
Hras -4011
Map2k1 -3355
Shc1 -3332
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Shc2 4210

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Map2k2 -4371
Hras -4011
Map2k1 -3355
Shc1 -3332
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Shc2 4210


REACTOME_EXTENSION_OF_TELOMERES

REACTOME_EXTENSION_OF_TELOMERES
448
set REACTOME_EXTENSION_OF_TELOMERES
setSize 13
pANOVA 0.149
s.dist -0.231
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ruvbl1 -4140
Nhp2 -4136
Ruvbl2 -3822
Pold4 -2995
Dkc1 -2695
Rfc4 -2586
Rpa2 -227
Pold2 70
Pola2 185
Rfc2 875
Pcna 1056
Rpa1 1137
Pold1 3003

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ruvbl1 -4140
Nhp2 -4136
Ruvbl2 -3822
Pold4 -2995
Dkc1 -2695
Rfc4 -2586
Rpa2 -227
Pold2 70
Pola2 185
Rfc2 875
Pcna 1056
Rpa1 1137
Pold1 3003


REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES

REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES
305
set REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES
setSize 12
pANOVA 0.175
s.dist 0.226
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Txnrd1 4541
Dtymk 3459
Glrx 3157
Rrm2b 2579
Txn1 2012
Nme1 1744
Guk1 1366
Gsr 948
Cmpk1 -200
Rrm1 -978
Ak2 -2975
Ak1 -3384

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Txnrd1 4541
Dtymk 3459
Glrx 3157
Rrm2b 2579
Txn1 2012
Nme1 1744
Guk1 1366
Gsr 948
Cmpk1 -200
Rrm1 -978
Ak2 -2975
Ak1 -3384


REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING

REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
57
set REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING
setSize 13
pANOVA 0.159
s.dist -0.226
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Map2k2 -4371
Hras -4011
Map2k1 -3355
Shc1 -3332
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Hbegf 4572

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Map2k2 -4371
Hras -4011
Map2k1 -3355
Shc1 -3332
Nras -2241
Ywhab -2122
Raf1 -1481
Grb2 -476
Kras -455
Mapk1 642
Sos1 692
Mapk3 2002
Hbegf 4572


REACTOME_BASIGIN_INTERACTIONS

REACTOME_BASIGIN_INTERACTIONS
136
set REACTOME_BASIGIN_INTERACTIONS
setSize 14
pANOVA 0.149
s.dist 0.223
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc7a8 4530
Slc16a1 4517
Ppil2 4418
Atp1b1 3585
Itgb1 3100
Itga3 2867
Slc7a6 1155
Slc3a2 863
Bsg 581
Cav1 -1838
Atp1b2 -1926
Slc16a3 -2003
Atp1b3 -2568
Ppia -3182

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc7a8 4530
Slc16a1 4517
Ppil2 4418
Atp1b1 3585
Itgb1 3100
Itga3 2867
Slc7a6 1155
Slc3a2 863
Bsg 581
Cav1 -1838
Atp1b2 -1926
Slc16a3 -2003
Atp1b3 -2568
Ppia -3182


REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE

REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE
203
set REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE
setSize 16
pANOVA 0.126
s.dist 0.221
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3r1 3760
Rhob 3211
Pdpk1 2951
Akt3 2806
Col1a2 2630
Col1a1 2215
Pik3ca 1925
Akt2 1434
Pik3cb 1354
Rac1 1285
Pik3r3 518
Fyn 385
Cdc42 -538
Rhog -1064
Akt1 -2346
Pik3r2 -4580

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3r1 3760
Rhob 3211
Pdpk1 2951
Akt3 2806
Col1a2 2630
Col1a1 2215
Pik3ca 1925
Akt2 1434
Pik3cb 1354
Rac1 1285
Pik3r3 518
Fyn 385
Cdc42 -538
Rhog -1064
Akt1 -2346
Pik3r2 -4580


REACTOME_ION_CHANNEL_TRANSPORT

REACTOME_ION_CHANNEL_TRANSPORT
367
set REACTOME_ION_CHANNEL_TRANSPORT
setSize 18
pANOVA 0.105
s.dist 0.221
p.adjustANOVA 0.719



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp8a1 4467
Atp1a2 4142
Atp1b1 3585
Atp9a 3434
Atp11a 2746
Atp1a1 2566
Arhgef9 2502
Atp11c 2240
Atp9b 1299
Atp2a1 702
Atp2a2 654
Atp2a3 557
Atp7a -391
Atp11b -1191
Atp1b2 -1926
Atp2b3 -2388
Atp2c1 -2496
Atp1b3 -2568

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp8a1 4467
Atp1a2 4142
Atp1b1 3585
Atp9a 3434
Atp11a 2746
Atp1a1 2566
Arhgef9 2502
Atp11c 2240
Atp9b 1299
Atp2a1 702
Atp2a2 654
Atp2a3 557
Atp7a -391
Atp11b -1191
Atp1b2 -1926
Atp2b3 -2388
Atp2c1 -2496
Atp1b3 -2568


REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX

REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
9
set REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
setSize 41
pANOVA 0.0168
s.dist -0.216
p.adjustANOVA 0.479



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif3j2 -3862
Rps11 -3788
Rps8 -3698
Rps27 -3389
Rps21 -3358
Rps24 -3181
Rps26 -2984
Rps14 -2832
Eif3f -2824
Rps9 -2737
Rps20 -2685
Rps29 -2599
Eif2s1 -2295
Rps4x -2276
Rps7 -2198
Eif3b -1979
Rps25 -1888
Eif2s2 -1757
Eif3i -1644
Rps6 -1333

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif3j2 -3862
Rps11 -3788
Rps8 -3698
Rps27 -3389
Rps21 -3358
Rps24 -3181
Rps26 -2984
Rps14 -2832
Eif3f -2824
Rps9 -2737
Rps20 -2685
Rps29 -2599
Eif2s1 -2295
Rps4x -2276
Rps7 -2198
Eif3b -1979
Rps25 -1888
Eif2s2 -1757
Eif3i -1644
Rps6 -1333
Eif1ax -1299
Eif3g -1294
Eif3c -1147
Rps23 -1093
Eif3d -902
Rps3a1 -899
Rps18 -897
Rps16 -302
Rps19 -190
Rps15a -125
Rpsa 273
Rps17 319
Rps27a 648
Eif3a 742
Rps3 1041
Eif2s3x 2036
Rps13 2100
Rps5 2431
Eif3k 2548
Eif3e 3108
Eif3h 4179


REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN
413
set REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN
setSize 23
pANOVA 0.0739
s.dist 0.215
p.adjustANOVA 0.671



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gck 4382
Nupl2 4334
Ranbp2 3601
Nup133 3358
Pom121 2492
Nup210 2445
Nup35 2353
Tpr 2262
Nup153 2199
Nup188 2136
Nup85 1681
Nup54 1654
Nup93 1084
Nup214 845
Nup62 609
Nup88 561
Nup37 -73
Nup205 -1122
Rae1 -1401
Nup155 -1461

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gck 4382
Nupl2 4334
Ranbp2 3601
Nup133 3358
Pom121 2492
Nup210 2445
Nup35 2353
Tpr 2262
Nup153 2199
Nup188 2136
Nup85 1681
Nup54 1654
Nup93 1084
Nup214 845
Nup62 609
Nup88 561
Nup37 -73
Nup205 -1122
Rae1 -1401
Nup155 -1461
Nup107 -2500
Aaas -2952
Seh1l -4157


REACTOME_MRNA_3_END_PROCESSING

REACTOME_MRNA_3_END_PROCESSING
240
set REACTOME_MRNA_3_END_PROCESSING
setSize 31
pANOVA 0.0405
s.dist 0.213
p.adjustANOVA 0.578



Top enriched genes

Top 20 genes
GeneID Gene Rank
Srrm1 4372
Srsf11 4260
Srsf6 4070
U2af1 3742
Upf3b 3702
Dhx38 3306
Srsf2 2986
Cpsf1 2894
Pcf11 2838
Papola 2827
Cstf1 2801
Srsf9 2697
Clp1 2550
Srsf7 2229
Cdc40 2174
Srsf1 2014
Srsf3 2003
Rnps1 1475
Cstf3 915
Ncbp1 423

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Srrm1 4372
Srsf11 4260
Srsf6 4070
U2af1 3742
Upf3b 3702
Dhx38 3306
Srsf2 2986
Cpsf1 2894
Pcf11 2838
Papola 2827
Cstf1 2801
Srsf9 2697
Clp1 2550
Srsf7 2229
Cdc40 2174
Srsf1 2014
Srsf3 2003
Rnps1 1475
Cstf3 915
Ncbp1 423
Cstf2 -1013
Srsf5 -1368
Magoh -1404
Nudt21 -1504
U2af2 -1863
Ncbp2 -2244
Cpsf3 -2264
Cpsf7 -2587
Cpsf2 -2630
Nfx1 -3306
Srsf4 -4404


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] plyr_1.8.7                  pkgload_1.3.0              
##  [3] GGally_2.1.2                gtools_3.9.2.2             
##  [5] echarts4r_0.4.4             beeswarm_0.4.0             
##  [7] vioplot_0.3.7               sm_2.2-5.7                 
##  [9] kableExtra_1.3.4            topconfects_1.12.0         
## [11] limma_3.52.1                eulerr_6.1.1               
## [13] mitch_1.8.0                 MASS_7.3-58                
## [15] fgsea_1.22.0                gplots_3.1.3               
## [17] DESeq2_1.36.0               SummarizedExperiment_1.26.1
## [19] Biobase_2.56.0              MatrixGenerics_1.8.0       
## [21] matrixStats_0.62.0          GenomicRanges_1.48.0       
## [23] GenomeInfoDb_1.32.2         IRanges_2.30.0             
## [25] S4Vectors_0.34.0            BiocGenerics_0.42.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.9                
## [31] purrr_0.3.4                 readr_2.1.2                
## [33] tidyr_1.2.0                 tibble_3.1.7               
## [35] ggplot2_3.3.6               tidyverse_1.3.1            
## [37] zoo_1.8-10                 
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.0           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      splines_4.2.1          BiocParallel_1.30.3   
##   [7] digest_0.6.29          htmltools_0.5.2        fansi_1.0.3           
##  [10] magrittr_2.0.3         memoise_2.0.1          tzdb_0.3.0            
##  [13] Biostrings_2.64.0      annotate_1.74.0        modelr_0.1.8          
##  [16] svglite_2.1.0          prettyunits_1.1.1      colorspace_2.0-3      
##  [19] blob_1.2.3             rvest_1.0.2            haven_2.5.0           
##  [22] xfun_0.31              crayon_1.5.1           RCurl_1.98-1.7        
##  [25] jsonlite_1.8.0         genefilter_1.78.0      survival_3.4-0        
##  [28] glue_1.6.2             gtable_0.3.0           zlibbioc_1.42.0       
##  [31] XVector_0.36.0         webshot_0.5.3          DelayedArray_0.22.0   
##  [34] scales_1.2.0           DBI_1.1.3              Rcpp_1.0.8.3          
##  [37] viridisLite_0.4.0      xtable_1.8-4           progress_1.2.2        
##  [40] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.3            
##  [43] RColorBrewer_1.1-3     ellipsis_0.3.2         pkgconfig_2.0.3       
##  [46] reshape_0.8.9          XML_3.99-0.10          farver_2.1.0          
##  [49] sass_0.4.1             dbplyr_2.2.1           locfit_1.5-9.5        
##  [52] utf8_1.2.2             tidyselect_1.1.2       labeling_0.4.2        
##  [55] rlang_1.0.3            later_1.3.0            AnnotationDbi_1.58.0  
##  [58] munsell_0.5.0          cellranger_1.1.0       tools_4.2.1           
##  [61] cachem_1.0.6           cli_3.3.0              generics_0.1.2        
##  [64] RSQLite_2.2.14         broom_0.8.0            evaluate_0.15         
##  [67] fastmap_1.1.0          yaml_2.3.5             knitr_1.39            
##  [70] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [73] KEGGREST_1.36.2        mime_0.12              xml2_1.3.3            
##  [76] compiler_4.2.1         rstudioapi_0.13        png_0.1-7             
##  [79] reprex_2.0.1           geneplotter_1.74.0     bslib_0.3.1           
##  [82] stringi_1.7.6          highr_0.9              lattice_0.20-45       
##  [85] Matrix_1.4-1           vctrs_0.4.1            pillar_1.7.0          
##  [88] lifecycle_1.0.1        jquerylib_0.1.4        data.table_1.14.2     
##  [91] bitops_1.0-7           httpuv_1.6.5           R6_2.5.1              
##  [94] promises_1.2.0.1       KernSmooth_2.23-20     gridExtra_2.3         
##  [97] codetools_0.2-18       assertthat_0.2.1       withr_2.5.0           
## [100] GenomeInfoDbData_1.2.8 parallel_4.2.1         hms_1.1.1             
## [103] grid_4.2.1             rmarkdown_2.14         shiny_1.7.1           
## [106] lubridate_1.8.0

END of report