Mitch Report

date generated: 2021-12-14

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA -3.6357295
## 7SK        1.3043811
## A1BG       4.8152148
## A1BG-AS1   2.3848769
## A2M       -2.7635507
## A2M-AS1    0.3180622

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2512
num_genes_in_profile	18743
duplicated_genes_present	0
num_profile_genes_in_sets	8604
num_profile_genes_not_in_sets	10139

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2512
num_genesets_excluded	1067
num_genesets_included	1445

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Cohesin Loading onto Chromatin	10	5.84e-06	-0.827	4.31e-05
RORA activates gene expression	18	5.97e-08	-0.738	5.60e-07
Peptide chain elongation	87	3.47e-31	0.719	6.26e-29
Viral mRNA Translation	87	8.76e-31	0.714	1.41e-28
Eukaryotic Translation Elongation	92	2.30e-32	0.713	6.64e-30
Selenocysteine synthesis	91	2.94e-31	0.704	6.07e-29
Activation of RAC1	11	5.66e-05	-0.701	3.55e-04
Establishment of Sister Chromatid Cohesion	11	6.09e-05	-0.698	3.77e-04
Eukaryotic Translation Termination	91	1.14e-30	0.697	1.64e-28
Regulation of signaling by CBL	18	4.22e-07	-0.689	3.57e-06
SRP-dependent cotranslational protein targeting to membrane	110	1.20e-34	0.677	4.55e-32
NOTCH2 intracellular domain regulates transcription	10	2.29e-04	-0.673	1.17e-03
tRNA processing in the mitochondrion	30	3.05e-10	-0.664	3.86e-09
Formation of a pool of free 40S subunits	99	7.91e-30	0.659	1.04e-27
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	9.58e-29	0.646	1.06e-26
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	4.67e-27	0.646	3.49e-25
Selenoamino acid metabolism	113	2.96e-32	0.643	7.12e-30
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	2.40e-04	-0.639	1.22e-03
PI3K events in ERBB2 signaling	13	1.16e-04	-0.617	6.51e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	73	7.67e-20	0.617	3.17e-18
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	74	4.64e-20	0.616	2.09e-18
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	4.90e-14	0.616	1.11e-12
p53-Independent DNA Damage Response	50	4.90e-14	0.616	1.11e-12
p53-Independent G1/S DNA damage checkpoint	50	4.90e-14	0.616	1.11e-12
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	70	8.89e-19	0.611	3.13e-17
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	71	6.88e-19	0.609	2.48e-17
APC/C:Cdc20 mediated degradation of Securin	66	1.16e-17	0.609	3.51e-16
Free fatty acids regulate insulin secretion	10	8.85e-04	-0.607	3.72e-03
APC/C:Cdc20 mediated degradation of Cyclin B	24	3.06e-07	0.604	2.65e-06
Negative regulation of NOTCH4 signaling	54	2.35e-14	0.600	5.74e-13
Autodegradation of Cdh1 by Cdh1:APC/C	64	1.29e-16	0.598	3.73e-15
DCC mediated attractive signaling	13	1.96e-04	-0.597	1.01e-03
L13a-mediated translational silencing of Ceruloplasmin expression	109	4.83e-27	0.596	3.49e-25
SCF(Skp2)-mediated degradation of p27/p21	59	2.41e-15	0.596	6.44e-14
CDK-mediated phosphorylation and removal of Cdc6	70	6.89e-18	0.595	2.31e-16
Vif-mediated degradation of APOBEC3G	52	1.19e-13	0.594	2.62e-12
APC-Cdc20 mediated degradation of Nek2A	26	1.68e-07	0.593	1.52e-06
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.63e-12	0.589	3.09e-11
Cap-dependent Translation Initiation	117	4.87e-28	0.587	4.14e-26
Eukaryotic Translation Initiation	117	4.87e-28	0.587	4.14e-26
Purine catabolism	13	2.48e-04	0.587	1.26e-03
Regulation of APC/C activators between G1/S and early anaphase	78	3.16e-19	0.587	1.17e-17
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.07e-14	0.586	2.73e-13
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.48e-13	0.586	3.20e-12
GTP hydrolysis and joining of the 60S ribosomal subunit	110	2.15e-26	0.586	1.48e-24
Phosphorylation of the APC/C	20	6.01e-06	0.585	4.38e-05
CDT1 association with the CDC6:ORC:origin complex	57	2.31e-14	0.584	5.74e-13
Signaling by NODAL	14	1.59e-04	-0.583	8.35e-04
Vpu mediated degradation of CD4	50	1.06e-12	0.582	2.10e-11
Ubiquitin-dependent degradation of Cyclin D	50	1.12e-12	0.581	2.16e-11

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Cohesin Loading onto Chromatin	10	5.84e-06	-0.827000	4.31e-05
RORA activates gene expression	18	5.97e-08	-0.738000	5.60e-07
Peptide chain elongation	87	3.47e-31	0.719000	6.26e-29
Viral mRNA Translation	87	8.76e-31	0.714000	1.41e-28
Eukaryotic Translation Elongation	92	2.30e-32	0.713000	6.64e-30
Selenocysteine synthesis	91	2.94e-31	0.704000	6.07e-29
Activation of RAC1	11	5.66e-05	-0.701000	3.55e-04
Establishment of Sister Chromatid Cohesion	11	6.09e-05	-0.698000	3.77e-04
Eukaryotic Translation Termination	91	1.14e-30	0.697000	1.64e-28
Regulation of signaling by CBL	18	4.22e-07	-0.689000	3.57e-06
SRP-dependent cotranslational protein targeting to membrane	110	1.20e-34	0.677000	4.55e-32
NOTCH2 intracellular domain regulates transcription	10	2.29e-04	-0.673000	1.17e-03
tRNA processing in the mitochondrion	30	3.05e-10	-0.664000	3.86e-09
Formation of a pool of free 40S subunits	99	7.91e-30	0.659000	1.04e-27
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	9.58e-29	0.646000	1.06e-26
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	4.67e-27	0.646000	3.49e-25
Selenoamino acid metabolism	113	2.96e-32	0.643000	7.12e-30
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	2.40e-04	-0.639000	1.22e-03
PI3K events in ERBB2 signaling	13	1.16e-04	-0.617000	6.51e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	73	7.67e-20	0.617000	3.17e-18
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	74	4.64e-20	0.616000	2.09e-18
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	4.90e-14	0.616000	1.11e-12
p53-Independent DNA Damage Response	50	4.90e-14	0.616000	1.11e-12
p53-Independent G1/S DNA damage checkpoint	50	4.90e-14	0.616000	1.11e-12
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	70	8.89e-19	0.611000	3.13e-17
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	71	6.88e-19	0.609000	2.48e-17
APC/C:Cdc20 mediated degradation of Securin	66	1.16e-17	0.609000	3.51e-16
Free fatty acids regulate insulin secretion	10	8.85e-04	-0.607000	3.72e-03
APC/C:Cdc20 mediated degradation of Cyclin B	24	3.06e-07	0.604000	2.65e-06
Negative regulation of NOTCH4 signaling	54	2.35e-14	0.600000	5.74e-13
Autodegradation of Cdh1 by Cdh1:APC/C	64	1.29e-16	0.598000	3.73e-15
DCC mediated attractive signaling	13	1.96e-04	-0.597000	1.01e-03
L13a-mediated translational silencing of Ceruloplasmin expression	109	4.83e-27	0.596000	3.49e-25
SCF(Skp2)-mediated degradation of p27/p21	59	2.41e-15	0.596000	6.44e-14
CDK-mediated phosphorylation and removal of Cdc6	70	6.89e-18	0.595000	2.31e-16
Vif-mediated degradation of APOBEC3G	52	1.19e-13	0.594000	2.62e-12
APC-Cdc20 mediated degradation of Nek2A	26	1.68e-07	0.593000	1.52e-06
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.63e-12	0.589000	3.09e-11
Cap-dependent Translation Initiation	117	4.87e-28	0.587000	4.14e-26
Eukaryotic Translation Initiation	117	4.87e-28	0.587000	4.14e-26
Purine catabolism	13	2.48e-04	0.587000	1.26e-03
Regulation of APC/C activators between G1/S and early anaphase	78	3.16e-19	0.587000	1.17e-17
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.07e-14	0.586000	2.73e-13
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.48e-13	0.586000	3.20e-12
GTP hydrolysis and joining of the 60S ribosomal subunit	110	2.15e-26	0.586000	1.48e-24
Phosphorylation of the APC/C	20	6.01e-06	0.585000	4.38e-05
CDT1 association with the CDC6:ORC:origin complex	57	2.31e-14	0.584000	5.74e-13
Signaling by NODAL	14	1.59e-04	-0.583000	8.35e-04
Vpu mediated degradation of CD4	50	1.06e-12	0.582000	2.10e-11
Ubiquitin-dependent degradation of Cyclin D	50	1.12e-12	0.581000	2.16e-11
Inactivation of APC/C via direct inhibition of the APC/C complex	21	4.18e-06	0.580000	3.14e-05
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	4.18e-06	0.580000	3.14e-05
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	8.71e-04	-0.580000	3.68e-03
SCF-beta-TrCP mediated degradation of Emi1	53	5.57e-13	0.572000	1.12e-11
Cytosolic tRNA aminoacylation	24	1.29e-06	0.571000	1.03e-05
Pregnenolone biosynthesis	10	1.91e-03	0.567000	7.09e-03
Formation of the ternary complex, and subsequently, the 43S complex	51	2.94e-12	0.565000	5.30e-11
Autodegradation of the E3 ubiquitin ligase COP1	49	9.33e-12	0.563000	1.51e-10
Hh mutants are degraded by ERAD	53	1.67e-12	0.560000	3.13e-11
Cross-presentation of soluble exogenous antigens (endosomes)	47	3.25e-11	0.559000	4.99e-10
Regulation of expression of SLITs and ROBOs	162	1.26e-34	0.558000	4.55e-32
NIK–>noncanonical NF-kB signaling	57	3.61e-13	0.556000	7.34e-12
RUNX3 regulates NOTCH signaling	14	3.18e-04	-0.556000	1.54e-03
Mitochondrial translation termination	91	5.42e-20	0.555000	2.37e-18
Mitochondrial translation initiation	91	5.83e-20	0.554000	2.48e-18
Mitochondrial iron-sulfur cluster biogenesis	13	5.52e-04	0.553000	2.50e-03
CD22 mediated BCR regulation	22	7.10e-06	0.553000	5.15e-05
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	5.51e-16	0.552000	1.50e-14
Mitochondrial translation elongation	91	1.10e-19	0.550000	4.29e-18
Signaling by PDGFRA extracellular domain mutants	12	9.67e-04	-0.550000	3.93e-03
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	9.67e-04	-0.550000	3.93e-03
Mitochondrial translation	97	9.37e-21	0.549000	4.51e-19
Regulation of ornithine decarboxylase (ODC)	49	3.22e-11	0.548000	4.99e-10
Striated Muscle Contraction	29	3.51e-07	0.546000	3.02e-06
Regulation of Apoptosis	51	1.86e-11	0.543000	2.99e-10
Hh mutants abrogate ligand secretion	55	3.17e-12	0.543000	5.66e-11
Translation	294	1.52e-57	0.541000	2.20e-54
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	1.19e-03	-0.540000	4.67e-03
Signaling by PDGFR in disease	20	2.92e-05	-0.540000	1.96e-04
APC/C-mediated degradation of cell cycle proteins	85	8.46e-18	0.539000	2.72e-16
Regulation of mitotic cell cycle	85	8.46e-18	0.539000	2.72e-16
Scavenging of heme from plasma	25	3.19e-06	0.538000	2.44e-05
Regulation of PTEN mRNA translation	11	2.07e-03	-0.536000	7.58e-03
NOTCH4 Intracellular Domain Regulates Transcription	19	5.35e-05	-0.535000	3.38e-04
Orc1 removal from chromatin	68	2.39e-14	0.535000	5.74e-13
Respiratory electron transport	103	8.14e-21	0.533000	4.06e-19
Dectin-1 mediated noncanonical NF-kB signaling	58	2.33e-12	0.532000	4.26e-11
Signaling by cytosolic FGFR1 fusion mutants	18	9.50e-05	-0.531000	5.56e-04
Mitochondrial Fatty Acid Beta-Oxidation	35	5.52e-08	0.531000	5.25e-07
RHOV GTPase cycle	34	9.05e-08	-0.530000	8.28e-07
Gluconeogenesis	28	1.29e-06	0.529000	1.03e-05
Switching of origins to a post-replicative state	88	9.95e-18	0.528000	3.13e-16
GAB1 signalosome	15	4.00e-04	-0.528000	1.88e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	3.27e-22	0.527000	1.75e-20
Nonsense-Mediated Decay (NMD)	113	3.27e-22	0.527000	1.75e-20
Mitochondrial protein import	64	3.00e-13	0.527000	6.19e-12
Stabilization of p53	54	2.39e-11	0.525000	3.80e-10
Folding of actin by CCT/TriC	10	4.05e-03	0.525000	1.26e-02
Regulation of FOXO transcriptional activity by acetylation	10	4.18e-03	-0.523000	1.28e-02
PKA-mediated phosphorylation of CREB	19	8.40e-05	-0.521000	5.01e-04
Nephrin family interactions	19	9.12e-05	-0.518000	5.38e-04
Signaling by KIT in disease	20	6.10e-05	-0.518000	3.77e-04
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	6.10e-05	-0.518000	3.77e-04
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	125	1.70e-23	0.517000	1.02e-21
Defective CFTR causes cystic fibrosis	59	6.86e-12	0.516000	1.17e-10
HuR (ELAVL1) binds and stabilizes mRNA	10	4.78e-03	-0.515000	1.45e-02
Cristae formation	31	7.16e-07	0.514000	5.88e-06
Gastrin-CREB signalling pathway via PKC and MAPK	16	3.81e-04	-0.513000	1.80e-03
Complex I biogenesis	57	2.73e-11	0.510000	4.29e-10
Cellular response to starvation	150	4.37e-27	0.509000	3.49e-25
Interconversion of nucleotide di- and triphosphates	29	2.07e-06	0.509000	1.61e-05
Signaling by FGFR4 in disease	10	5.39e-03	-0.508000	1.60e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.55e-10	0.508000	2.09e-09
Degradation of DVL	55	7.29e-11	0.508000	1.07e-09
Acetylcholine regulates insulin secretion	10	5.62e-03	-0.506000	1.65e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	5.72e-03	-0.505000	1.67e-02
Regulation of RUNX3 expression and activity	55	1.05e-10	0.503000	1.47e-09
Degradation of AXIN	53	2.46e-10	0.502000	3.15e-09
RHOU GTPase cycle	39	5.76e-08	-0.502000	5.44e-07
p53-Dependent G1 DNA Damage Response	62	9.20e-12	0.501000	1.51e-10
p53-Dependent G1/S DNA damage checkpoint	62	9.20e-12	0.501000	1.51e-10
Metabolism of polyamines	57	6.51e-11	0.500000	9.70e-10
ROS sensing by NFE2L2	55	1.83e-10	0.497000	2.41e-09
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	4.47e-11	0.496000	6.80e-10
G1/S DNA Damage Checkpoints	64	7.62e-12	0.495000	1.28e-10
Ribosomal scanning and start codon recognition	58	7.42e-11	0.494000	1.07e-09
Heme signaling	44	1.63e-08	-0.492000	1.65e-07
Cyclin A/B1/B2 associated events during G2/M transition	23	4.51e-05	0.491000	2.91e-04
Translation initiation complex formation	58	1.10e-10	0.490000	1.53e-09
MET activates RAP1 and RAC1	11	5.09e-03	-0.488000	1.53e-02
Downstream signal transduction	29	5.90e-06	-0.486000	4.32e-05
Erythrocytes take up carbon dioxide and release oxygen	11	5.47e-03	0.484000	1.61e-02
O2/CO2 exchange in erythrocytes	11	5.47e-03	0.484000	1.61e-02
PKA activation in glucagon signalling	16	8.16e-04	-0.483000	3.51e-03
Cytosolic iron-sulfur cluster assembly	13	2.67e-03	0.481000	8.97e-03
PKA activation	17	6.03e-04	-0.481000	2.69e-03
Signaling by Erythropoietin	24	4.62e-05	-0.480000	2.96e-04
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	1.01e-04	-0.479000	5.85e-04
Major pathway of rRNA processing in the nucleolus and cytosol	179	2.78e-28	0.477000	2.68e-26
rRNA processing in the nucleus and cytosol	189	1.26e-29	0.476000	1.52e-27
Degradation of GLI1 by the proteasome	57	5.06e-10	0.476000	6.36e-09
Mitotic Telophase/Cytokinesis	13	2.97e-03	-0.476000	9.78e-03
GLI3 is processed to GLI3R by the proteasome	57	5.32e-10	0.475000	6.63e-09
Signaling by Leptin	11	6.35e-03	-0.475000	1.81e-02
Hedgehog ligand biogenesis	60	2.29e-10	0.473000	2.95e-09
Degradation of GLI2 by the proteasome	57	6.58e-10	0.473000	8.12e-09
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	7.32e-11	0.471000	1.07e-09
Signaling by Hippo	20	2.68e-04	-0.471000	1.35e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling	40	2.61e-07	-0.470000	2.27e-06
ERBB2 Activates PTK6 Signaling	10	1.03e-02	-0.469000	2.80e-02
Processing of SMDT1	15	1.70e-03	0.468000	6.44e-03
RHOJ GTPase cycle	53	3.81e-09	-0.468000	4.27e-08
ERBB2 Regulates Cell Motility	12	5.06e-03	-0.467000	1.52e-02
PI-3K cascade:FGFR1	14	2.58e-03	-0.465000	8.77e-03
Formation of ATP by chemiosmotic coupling	18	6.34e-04	0.465000	2.80e-03
Tie2 Signaling	17	9.43e-04	-0.463000	3.87e-03
Signaling by FLT3 fusion proteins	19	5.01e-04	-0.461000	2.29e-03
Thrombin signalling through proteinase activated receptors (PARs)	27	3.60e-05	-0.459000	2.35e-04
PECAM1 interactions	12	5.89e-03	-0.459000	1.70e-02
Synthesis of DNA	117	1.13e-17	0.458000	3.47e-16
Influenza Viral RNA Transcription and Replication	134	9.66e-20	0.455000	3.88e-18
Keratan sulfate degradation	12	6.45e-03	0.454000	1.83e-02
Assembly of the pre-replicative complex	78	4.07e-12	0.454000	7.08e-11
CD209 (DC-SIGN) signaling	20	4.64e-04	-0.452000	2.14e-03
tRNA Aminoacylation	42	3.96e-07	0.452000	3.36e-06
Prefoldin mediated transfer of substrate to CCT/TriC	27	4.93e-05	0.451000	3.15e-04
Glucagon signaling in metabolic regulation	28	3.61e-05	-0.451000	2.35e-04
Regulation of KIT signaling	16	1.80e-03	-0.451000	6.74e-03
ABC transporters in lipid homeostasis	13	4.95e-03	-0.450000	1.49e-02
Amine ligand-binding receptors	18	9.87e-04	-0.448000	4.01e-03
Signaling by FGFR3 fusions in cancer	10	1.42e-02	-0.448000	3.64e-02
GRB2 events in ERBB2 signaling	13	5.20e-03	-0.448000	1.56e-02
Tryptophan catabolism	11	1.06e-02	0.445000	2.85e-02
NOTCH3 Intracellular Domain Regulates Transcription	22	3.02e-04	-0.445000	1.47e-03
Regulation of MECP2 expression and activity	29	3.56e-05	-0.444000	2.35e-04
RHOQ GTPase cycle	58	5.16e-09	-0.443000	5.74e-08
Classical antibody-mediated complement activation	25	1.25e-04	0.443000	6.90e-04
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	30	2.74e-05	0.442000	1.85e-04
CLEC7A (Dectin-1) induces NFAT activation	11	1.11e-02	-0.442000	2.95e-02
Regulation of RUNX2 expression and activity	71	1.53e-10	0.439000	2.09e-09
Prolonged ERK activation events	14	4.46e-03	-0.439000	1.36e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	1.65e-02	0.438000	4.13e-02
The citric acid (TCA) cycle and respiratory electron transport	172	3.73e-23	0.438000	2.16e-21
Regulation of HMOX1 expression and activity	63	1.94e-09	0.437000	2.26e-08
Signaling by WNT in cancer	28	6.25e-05	-0.437000	3.84e-04
FOXO-mediated transcription of cell death genes	15	3.68e-03	-0.433000	1.15e-02
P2Y receptors	11	1.32e-02	-0.431000	3.44e-02
Signaling by FLT3 ITD and TKD mutants	16	2.92e-03	-0.430000	9.64e-03
Synthesis of PIPs at the plasma membrane	52	8.57e-08	-0.429000	7.89e-07
Interleukin-7 signaling	21	6.84e-04	-0.428000	2.98e-03
Signal transduction by L1	21	6.85e-04	-0.428000	2.98e-03
Signal regulatory protein family interactions	11	1.45e-02	-0.425000	3.69e-02
Recycling pathway of L1	27	1.35e-04	-0.424000	7.34e-04
FGFR1 mutant receptor activation	26	1.90e-04	-0.423000	9.92e-04
Growth hormone receptor signaling	20	1.07e-03	-0.423000	4.26e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	1.11e-03	0.421000	4.37e-03
DNA Replication	135	2.90e-17	0.421000	8.54e-16
DNA Replication Pre-Initiation	93	2.27e-12	0.421000	4.21e-11
Regulation of localization of FOXO transcription factors	12	1.16e-02	-0.421000	3.06e-02
G-protein beta:gamma signalling	28	1.23e-04	-0.419000	6.85e-04
Signaling by SCF-KIT	43	2.09e-06	-0.418000	1.63e-05
cGMP effects	15	5.26e-03	-0.416000	1.57e-02
Signaling by FGFR1 in disease	33	3.58e-05	-0.416000	2.35e-04
Cyclin E associated events during G1/S transition	82	7.62e-11	0.416000	1.09e-09
Vasopressin regulates renal water homeostasis via Aquaporins	35	2.10e-05	-0.415000	1.45e-04
RHOC GTPase cycle	70	2.26e-09	-0.413000	2.60e-08
Regulation of beta-cell development	21	1.07e-03	-0.412000	4.26e-03
Regulated proteolysis of p75NTR	11	1.79e-02	-0.412000	4.41e-02
RHOB GTPase cycle	66	7.31e-09	-0.412000	7.89e-08
PLC beta mediated events	46	1.44e-06	-0.411000	1.15e-05
Glycogen synthesis	15	6.23e-03	0.408000	1.78e-02
ER-Phagosome pathway	85	7.99e-11	0.408000	1.13e-09
Cyclin A:Cdk2-associated events at S phase entry	84	1.11e-10	0.407000	1.53e-09
Formation of tubulin folding intermediates by CCT/TriC	23	7.55e-04	0.406000	3.26e-03
Diseases associated with glycosylation precursor biosynthesis	18	2.89e-03	0.406000	9.58e-03
G-protein mediated events	50	7.09e-07	-0.405000	5.85e-06
ABC transporter disorders	69	6.01e-09	0.405000	6.53e-08
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	8.95e-03	-0.404000	2.48e-02
Signaling by ERBB2 KD Mutants	22	1.06e-03	-0.403000	4.26e-03
Cholesterol biosynthesis	24	6.38e-04	0.403000	2.80e-03
Activation of NF-kappaB in B cells	65	1.96e-08	0.403000	1.96e-07
Nucleotide salvage	21	1.46e-03	0.401000	5.63e-03
Signaling by ERBB2 in Cancer	23	8.99e-04	-0.400000	3.77e-03
Metabolism of amino acids and derivatives	323	4.49e-35	0.400000	3.25e-32
RAC2 GTPase cycle	85	2.05e-10	-0.399000	2.67e-09
Activated NTRK2 signals through FRS2 and FRS3	10	2.90e-02	-0.399000	6.58e-02
Cellular response to hypoxia	72	5.69e-09	0.397000	6.28e-08
G beta:gamma signalling through CDC42	16	5.99e-03	-0.397000	1.73e-02
TNFR2 non-canonical NF-kB pathway	91	6.02e-11	0.397000	9.06e-10
Response of EIF2AK1 (HRI) to heme deficiency	15	7.83e-03	0.397000	2.19e-02
PI Metabolism	80	8.85e-10	-0.396000	1.07e-08
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	6.18e-04	-0.396000	2.75e-03
EPHA-mediated growth cone collapse	15	8.13e-03	-0.395000	2.27e-02
RAC1 GTPase cycle	176	1.90e-19	-0.394000	7.22e-18
EGR2 and SOX10-mediated initiation of Schwann cell myelination	24	8.37e-04	-0.394000	3.58e-03
Synthesis of PIPs at the early endosome membrane	16	6.43e-03	-0.393000	1.83e-02
Laminin interactions	23	1.09e-03	-0.393000	4.34e-03
G beta:gamma signalling through PI3Kgamma	21	1.88e-03	-0.392000	6.97e-03
CDC42 GTPase cycle	147	3.06e-16	-0.390000	8.50e-15
Thromboxane signalling through TP receptor	20	2.58e-03	-0.389000	8.77e-03
RHOD GTPase cycle	50	1.93e-06	-0.389000	1.53e-05
DAG and IP3 signaling	38	3.48e-05	-0.388000	2.31e-04
SHC1 events in ERBB2 signaling	19	3.46e-03	-0.387000	1.09e-02
Constitutive Signaling by Aberrant PI3K in Cancer	60	2.15e-07	-0.387000	1.88e-06
ADP signalling through P2Y purinoceptor 1	21	2.15e-03	-0.387000	7.79e-03
CaM pathway	32	1.53e-04	-0.387000	8.15e-04
Calmodulin induced events	32	1.53e-04	-0.387000	8.15e-04
mRNA decay by 3’ to 5’ exoribonuclease	16	7.47e-03	0.386000	2.11e-02
G1/S Transition	128	4.58e-14	0.386000	1.08e-12
Heme biosynthesis	13	1.60e-02	0.386000	4.02e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	73	1.29e-08	0.385000	1.33e-07
G beta:gamma signalling through PLC beta	16	7.69e-03	-0.385000	2.16e-02
RHO GTPases activate PAKs	21	2.27e-03	-0.385000	8.01e-03
Surfactant metabolism	21	2.35e-03	-0.383000	8.19e-03
Influenza Infection	153	2.71e-16	0.383000	7.67e-15
Asymmetric localization of PCP proteins	62	1.89e-07	0.383000	1.68e-06
Synthesis of pyrophosphates in the cytosol	10	3.64e-02	-0.382000	7.87e-02
RET signaling	37	5.95e-05	-0.381000	3.72e-04
Ca-dependent events	34	1.28e-04	-0.379000	7.03e-04
Glutathione conjugation	30	3.24e-04	0.379000	1.57e-03
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.98e-02	0.378000	6.74e-02
Activation of NMDA receptors and postsynaptic events	65	1.34e-07	-0.378000	1.22e-06
Post NMDA receptor activation events	54	1.55e-06	-0.378000	1.23e-05
Creation of C4 and C2 activators	29	4.47e-04	0.377000	2.07e-03
Nuclear signaling by ERBB4	28	5.70e-04	-0.376000	2.57e-03
Frs2-mediated activation	12	2.43e-02	-0.375000	5.65e-02
Regulation of RAS by GAPs	65	1.80e-07	0.374000	1.61e-06
FLT3 Signaling	38	6.59e-05	-0.374000	4.01e-04
Metabolism of nucleotides	86	2.24e-09	0.373000	2.59e-08
rRNA processing	216	3.63e-21	0.373000	1.87e-19
STAT5 activation downstream of FLT3 ITD mutants	10	4.13e-02	-0.373000	8.79e-02
Repression of WNT target genes	14	1.66e-02	-0.370000	4.15e-02
Transferrin endocytosis and recycling	29	5.73e-04	0.369000	2.58e-03
Signaling by ERBB2 ECD mutants	16	1.07e-02	-0.369000	2.87e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.30e-04	-0.369000	7.06e-04
CD28 dependent Vav1 pathway	11	3.52e-02	-0.367000	7.66e-02
Nitric oxide stimulates guanylate cyclase	19	5.88e-03	-0.365000	1.70e-02
VxPx cargo-targeting to cilium	17	9.21e-03	-0.365000	2.53e-02
Notch-HLH transcription pathway	28	8.39e-04	-0.365000	3.58e-03
Synthesis of glycosylphosphatidylinositol (GPI)	18	7.50e-03	0.364000	2.11e-02
RND2 GTPase cycle	38	1.11e-04	-0.362000	6.29e-04
Signal amplification	28	9.20e-04	-0.362000	3.82e-03
TICAM1-dependent activation of IRF3/IRF7	12	3.01e-02	0.362000	6.77e-02
MET receptor recycling	10	4.78e-02	-0.361000	9.70e-02
MET activates PTK2 signaling	18	8.03e-03	-0.361000	2.24e-02
GPVI-mediated activation cascade	30	6.30e-04	-0.361000	2.78e-03
Aquaporin-mediated transport	38	1.21e-04	-0.360000	6.78e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	3.47e-04	-0.360000	1.67e-03
RND3 GTPase cycle	37	1.56e-04	-0.359000	8.28e-04
APC truncation mutants have impaired AXIN binding	14	2.00e-02	-0.359000	4.81e-02
AXIN missense mutants destabilize the destruction complex	14	2.00e-02	-0.359000	4.81e-02
Signaling by AMER1 mutants	14	2.00e-02	-0.359000	4.81e-02
Signaling by APC mutants	14	2.00e-02	-0.359000	4.81e-02
Signaling by AXIN mutants	14	2.00e-02	-0.359000	4.81e-02
Truncations of AMER1 destabilize the destruction complex	14	2.00e-02	-0.359000	4.81e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	5.52e-03	0.358000	1.63e-02
FCERI mediated NF-kB activation	92	2.86e-09	0.358000	3.23e-08
Signaling by BMP	24	2.40e-03	-0.358000	8.27e-03
RAC3 GTPase cycle	87	8.11e-09	-0.358000	8.68e-08
Mitochondrial calcium ion transport	22	3.73e-03	0.357000	1.16e-02
Pyrimidine salvage	10	5.06e-02	0.357000	1.01e-01
MET promotes cell motility	28	1.10e-03	-0.356000	4.35e-03
Purine salvage	12	3.27e-02	0.356000	7.23e-02
Signaling by ROBO receptors	203	2.25e-18	0.356000	7.74e-17
SUMOylation of intracellular receptors	27	1.43e-03	-0.354000	5.55e-03
rRNA processing in the mitochondrion	27	1.45e-03	-0.354000	5.59e-03
Insulin receptor recycling	23	3.31e-03	0.354000	1.06e-02
Diseases associated with N-glycosylation of proteins	17	1.17e-02	0.353000	3.08e-02
Presynaptic function of Kainate receptors	17	1.18e-02	-0.353000	3.11e-02
Disorders of Developmental Biology	13	2.80e-02	-0.352000	6.37e-02
Disorders of Nervous System Development	13	2.80e-02	-0.352000	6.37e-02
Loss of function of MECP2 in Rett syndrome	13	2.80e-02	-0.352000	6.37e-02
Pervasive developmental disorders	13	2.80e-02	-0.352000	6.37e-02
Activation of SMO	16	1.52e-02	-0.351000	3.84e-02
NR1H2 and NR1H3-mediated signaling	40	1.27e-04	-0.350000	6.99e-04
Ephrin signaling	19	8.25e-03	-0.350000	2.30e-02
CDC6 association with the ORC:origin complex	11	4.44e-02	0.350000	9.35e-02
RHOF GTPase cycle	39	1.59e-04	-0.349000	8.35e-04
G alpha (12/13) signalling events	74	2.01e-07	-0.349000	1.77e-06
Interaction between L1 and Ankyrins	24	3.07e-03	-0.349000	9.93e-03
RHO GTPases Activate WASPs and WAVEs	36	2.96e-04	-0.348000	1.46e-03
ADP signalling through P2Y purinoceptor 12	17	1.29e-02	-0.348000	3.36e-02
Uptake and function of anthrax toxins	11	4.68e-02	-0.346000	9.67e-02
G beta:gamma signalling through BTK	14	2.50e-02	-0.346000	5.79e-02
Ca2+ pathway	56	7.98e-06	-0.345000	5.77e-05
Mitochondrial tRNA aminoacylation	21	6.24e-03	0.345000	1.78e-02
Myogenesis	22	5.27e-03	-0.344000	1.57e-02
Activation of AMPK downstream of NMDARs	10	6.04e-02	-0.343000	1.17e-01
Dissolution of Fibrin Clot	10	6.05e-02	0.343000	1.17e-01
G-protein activation	19	9.74e-03	-0.343000	2.66e-02
Regulation of PTEN stability and activity	67	1.28e-06	0.342000	1.03e-05
PI3K/AKT Signaling in Cancer	87	3.51e-08	-0.342000	3.43e-07
Mitotic G1 phase and G1/S transition	146	1.08e-12	0.341000	2.10e-11
Signaling by Activin	14	2.72e-02	-0.341000	6.23e-02
Adenylate cyclase activating pathway	10	6.21e-02	-0.341000	1.19e-01
ERK/MAPK targets	22	5.76e-03	-0.340000	1.68e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	87	4.81e-08	-0.339000	4.67e-07
Interleukin-6 signaling	11	5.19e-02	-0.338000	1.03e-01
Constitutive Signaling by EGFRvIII	15	2.36e-02	-0.338000	5.51e-02
Signaling by EGFRvIII in Cancer	15	2.36e-02	-0.338000	5.51e-02
Signaling by FGFR2 IIIa TM	19	1.09e-02	0.337000	2.91e-02
CASP8 activity is inhibited	10	6.50e-02	0.337000	1.22e-01
Dimerization of procaspase-8	10	6.50e-02	0.337000	1.22e-01
Regulation by c-FLIP	10	6.50e-02	0.337000	1.22e-01
Translesion Synthesis by POLH	18	1.36e-02	0.336000	3.50e-02
FLT3 signaling in disease	28	2.11e-03	-0.336000	7.67e-03
AKT phosphorylates targets in the nucleus	10	6.62e-02	-0.336000	1.24e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	2.98e-02	-0.335000	6.74e-02
Regulation of BACH1 activity	11	5.43e-02	0.335000	1.07e-01
SLBP independent Processing of Histone Pre-mRNAs	10	6.71e-02	0.334000	1.24e-01
Negative regulation of the PI3K/AKT network	94	2.19e-08	-0.334000	2.17e-07
Cell-Cell communication	94	2.57e-08	-0.332000	2.53e-07
Translesion synthesis by REV1	16	2.14e-02	0.332000	5.09e-02
Olfactory Signaling Pathway	12	4.63e-02	-0.332000	9.66e-02
Glycogen storage diseases	14	3.15e-02	0.332000	7.06e-02
Antigen processing-Cross presentation	100	1.19e-08	0.330000	1.23e-07
RNA Pol II CTD phosphorylation and interaction with CE	27	3.02e-03	0.330000	9.84e-03
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	3.02e-03	0.330000	9.84e-03
Glucagon-type ligand receptors	20	1.07e-02	-0.330000	2.87e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	34	9.05e-04	-0.329000	3.78e-03
Netrin-1 signaling	43	1.95e-04	-0.328000	1.01e-03
Antimicrobial peptides	24	5.42e-03	0.328000	1.61e-02
Signaling by ERBB2 TMD/JMD mutants	19	1.34e-02	-0.328000	3.47e-02
Regulation of TP53 Activity through Association with Co-factors	11	6.01e-02	-0.327000	1.16e-01
RUNX3 regulates p14-ARF	10	7.31e-02	-0.327000	1.34e-01
Resolution of Abasic Sites (AP sites)	38	5.01e-04	0.326000	2.29e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	3.42e-03	-0.326000	1.08e-02
Regulation of insulin secretion	63	8.35e-06	-0.325000	6.00e-05
Citric acid cycle (TCA cycle)	22	8.54e-03	0.324000	2.37e-02
Activation of ATR in response to replication stress	35	9.61e-04	0.322000	3.93e-03
Synthesis of PIPs at the late endosome membrane	11	6.45e-02	-0.322000	1.22e-01
FRS-mediated FGFR1 signaling	16	2.61e-02	-0.321000	6.02e-02
mRNA Capping	29	2.77e-03	0.321000	9.24e-03
Erythropoietin activates RAS	13	4.56e-02	-0.320000	9.54e-02
VEGFA-VEGFR2 Pathway	94	8.09e-08	-0.320000	7.49e-07
Translesion synthesis by POLI	17	2.25e-02	0.320000	5.30e-02
GRB2 events in EGFR signaling	11	6.70e-02	-0.319000	1.24e-01
UCH proteinases	85	3.80e-07	0.319000	3.25e-06
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	5.61e-02	-0.319000	1.10e-01
Synthesis, secretion, and deacylation of Ghrelin	14	3.95e-02	0.318000	8.47e-02
RUNX2 regulates bone development	28	3.65e-03	-0.317000	1.14e-02
Formation of TC-NER Pre-Incision Complex	53	6.61e-05	0.317000	4.01e-04
IRS-related events triggered by IGF1R	42	3.96e-04	-0.316000	1.86e-03
Formation of the cornified envelope	22	1.03e-02	-0.316000	2.81e-02
FCGR activation	32	2.01e-03	0.315000	7.40e-03
Signaling by PDGF	50	1.22e-04	-0.314000	6.80e-04
MASTL Facilitates Mitotic Progression	10	8.59e-02	0.314000	1.54e-01
PI-3K cascade:FGFR4	14	4.23e-02	-0.313000	8.97e-02
Adenylate cyclase inhibitory pathway	13	5.06e-02	-0.313000	1.01e-01
Signaling by ERBB4	51	1.09e-04	-0.313000	6.22e-04
RIPK1-mediated regulated necrosis	28	4.14e-03	0.313000	1.27e-02
Regulation of necroptotic cell death	28	4.14e-03	0.313000	1.27e-02
Nucleotide catabolism	27	4.94e-03	0.313000	1.49e-02
BBSome-mediated cargo-targeting to cilium	21	1.34e-02	0.312000	3.48e-02
Nucleotide-like (purinergic) receptors	15	3.71e-02	-0.311000	8.00e-02
G2/M Checkpoints	132	6.92e-10	0.311000	8.47e-09
Aflatoxin activation and detoxification	13	5.25e-02	0.311000	1.04e-01
Signaling by VEGF	103	5.23e-08	-0.310000	5.03e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane	51	1.27e-04	-0.310000	7.00e-04
Collagen degradation	33	2.10e-03	0.309000	7.67e-03
Metabolism of cofactors	19	1.96e-02	0.309000	4.77e-02
Cell-extracellular matrix interactions	16	3.32e-02	-0.308000	7.31e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	14	4.68e-02	-0.307000	9.67e-02
Defective EXT2 causes exostoses 2	14	4.68e-02	-0.307000	9.67e-02
Signaling by EGFR	47	2.73e-04	-0.307000	1.37e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	34	1.97e-03	0.307000	7.25e-03
Suppression of phagosomal maturation	13	5.57e-02	0.306000	1.09e-01
Interleukin-35 Signalling	11	7.85e-02	-0.306000	1.43e-01
Base-Excision Repair, AP Site Formation	24	9.95e-03	0.304000	2.71e-02
Chemokine receptors bind chemokines	37	1.38e-03	0.304000	5.36e-03
G alpha (z) signalling events	40	8.81e-04	-0.304000	3.71e-03
Integration of energy metabolism	91	5.57e-07	-0.304000	4.68e-06
DNA Damage Recognition in GG-NER	38	1.24e-03	0.303000	4.84e-03
Prostacyclin signalling through prostacyclin receptor	15	4.26e-02	-0.302000	9.01e-02
Glutathione synthesis and recycling	11	8.38e-02	0.301000	1.51e-01
RHOG GTPase cycle	71	1.17e-05	-0.301000	8.30e-05
Sema4D in semaphorin signaling	24	1.08e-02	-0.301000	2.87e-02
Interleukin receptor SHC signaling	23	1.26e-02	-0.300000	3.30e-02
CD28 co-stimulation	32	3.39e-03	-0.299000	1.08e-02
Detoxification of Reactive Oxygen Species	33	2.98e-03	0.299000	9.78e-03
Downstream signaling events of B Cell Receptor (BCR)	79	4.45e-06	0.299000	3.33e-05
Transcriptional regulation of pluripotent stem cells	17	3.32e-02	-0.298000	7.31e-02
Formation of the Early Elongation Complex	33	3.02e-03	0.298000	9.84e-03
Formation of the HIV-1 Early Elongation Complex	33	3.02e-03	0.298000	9.84e-03
Synthesis of PE	12	7.37e-02	0.298000	1.35e-01
Deposition of new CENPA-containing nucleosomes at the centromere	34	2.64e-03	0.298000	8.91e-03
Nucleosome assembly	34	2.64e-03	0.298000	8.91e-03
Signaling by RAF1 mutants	35	2.29e-03	-0.298000	8.03e-03
Neurotransmitter receptors and postsynaptic signal transmission	134	2.76e-09	-0.297000	3.13e-08
ATF6 (ATF6-alpha) activates chaperone genes	10	1.05e-01	0.296000	1.84e-01
Protein localization	157	1.71e-10	0.295000	2.28e-09
RHOH GTPase cycle	33	3.33e-03	-0.295000	1.06e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.11e-02	0.295000	8.76e-02
Oncogenic MAPK signaling	74	1.15e-05	-0.295000	8.25e-05
Apoptotic factor-mediated response	20	2.28e-02	0.294000	5.35e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	2.28e-03	0.294000	8.01e-03
rRNA modification in the nucleus and cytosol	59	9.76e-05	0.293000	5.68e-04
S Phase	159	1.82e-10	0.293000	2.41e-09
Interleukin-27 signaling	10	1.09e-01	-0.293000	1.91e-01
FGFR2 alternative splicing	25	1.15e-02	0.292000	3.04e-02
Regulated Necrosis	50	4.04e-04	0.289000	1.89e-03
HS-GAG biosynthesis	24	1.43e-02	-0.289000	3.65e-02
IGF1R signaling cascade	43	1.06e-03	-0.289000	4.26e-03
RHO GTPases Activate ROCKs	19	3.01e-02	-0.287000	6.77e-02
Initial triggering of complement	35	3.28e-03	0.287000	1.06e-02
Synthesis of PIPs at the Golgi membrane	15	5.42e-02	-0.287000	1.07e-01
Non-integrin membrane-ECM interactions	41	1.47e-03	-0.287000	5.65e-03
Fanconi Anemia Pathway	35	3.30e-03	0.287000	1.06e-02
Post-chaperonin tubulin folding pathway	20	2.70e-02	0.286000	6.19e-02
IRS-mediated signalling	39	2.05e-03	-0.285000	7.50e-03
RNA Polymerase II Transcription Termination	65	6.96e-05	0.285000	4.19e-04
Synthesis of substrates in N-glycan biosythesis	59	1.56e-04	0.285000	8.26e-04
Iron uptake and transport	55	2.69e-04	0.284000	1.35e-03
ATF4 activates genes in response to endoplasmic reticulum stress	27	1.08e-02	0.284000	2.87e-02
Interleukin-2 family signaling	37	2.84e-03	-0.284000	9.44e-03
L1CAM interactions	91	2.95e-06	-0.284000	2.27e-05
Regulation of innate immune responses to cytosolic DNA	14	6.67e-02	0.283000	1.24e-01
ALK mutants bind TKIs	12	8.97e-02	-0.283000	1.60e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	39	2.25e-03	-0.283000	7.96e-03
Signaling by RAS mutants	39	2.25e-03	-0.283000	7.96e-03
Signaling by moderate kinase activity BRAF mutants	39	2.25e-03	-0.283000	7.96e-03
Signaling downstream of RAS mutants	39	2.25e-03	-0.283000	7.96e-03
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	1.90e-02	-0.283000	4.64e-02
Transcriptional Regulation by MECP2	49	6.21e-04	-0.283000	2.75e-03
Opioid Signalling	81	1.16e-05	-0.282000	8.25e-05
Signaling by ERBB2	47	8.38e-04	-0.282000	3.58e-03
Deactivation of the beta-catenin transactivating complex	39	2.38e-03	-0.281000	8.24e-03
PI3K Cascade	35	4.07e-03	-0.281000	1.26e-02
Telomere Extension By Telomerase	21	2.61e-02	0.280000	6.02e-02
PIWI-interacting RNA (piRNA) biogenesis	22	2.29e-02	0.280000	5.37e-02
Negative regulation of MET activity	20	3.05e-02	-0.279000	6.86e-02
Interleukin-1 signaling	97	2.02e-06	0.279000	1.59e-05
Downstream signaling of activated FGFR1	23	2.05e-02	-0.279000	4.92e-02
TRAF3-dependent IRF activation pathway	14	7.06e-02	-0.279000	1.30e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	3.38e-05	0.279000	2.25e-04
Insulin receptor signalling cascade	44	1.41e-03	-0.278000	5.47e-03
PKMTs methylate histone lysines	43	1.60e-03	-0.278000	6.11e-03
RND1 GTPase cycle	39	2.66e-03	-0.278000	8.97e-03
SHC1 events in ERBB4 signaling	11	1.10e-01	-0.278000	1.92e-01
Signaling by high-kinase activity BRAF mutants	31	7.42e-03	-0.278000	2.10e-02
Extra-nuclear estrogen signaling	67	8.43e-05	-0.278000	5.01e-04
MAPK3 (ERK1) activation	10	1.29e-01	-0.277000	2.16e-01
Metabolism of steroid hormones	23	2.24e-02	0.275000	5.28e-02
S33 mutants of beta-catenin aren’t phosphorylated	15	6.59e-02	-0.274000	1.23e-01
S37 mutants of beta-catenin aren’t phosphorylated	15	6.59e-02	-0.274000	1.23e-01
S45 mutants of beta-catenin aren’t phosphorylated	15	6.59e-02	-0.274000	1.23e-01
Signaling by CTNNB1 phospho-site mutants	15	6.59e-02	-0.274000	1.23e-01
Signaling by GSK3beta mutants	15	6.59e-02	-0.274000	1.23e-01
T41 mutants of beta-catenin aren’t phosphorylated	15	6.59e-02	-0.274000	1.23e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	1.15e-01	-0.274000	1.99e-01
Translesion synthesis by POLK	17	5.05e-02	0.274000	1.01e-01
RUNX2 regulates osteoblast differentiation	22	2.62e-02	-0.274000	6.02e-02
Regulation of RUNX1 Expression and Activity	18	4.47e-02	-0.273000	9.39e-02
EGFR downregulation	28	1.24e-02	-0.273000	3.25e-02
CTLA4 inhibitory signaling	19	3.97e-02	-0.273000	8.50e-02
Signaling by BRAF and RAF1 fusions	58	3.31e-04	-0.273000	1.59e-03
NRAGE signals death through JNK	57	3.77e-04	-0.272000	1.79e-03
RHOA GTPase cycle	144	1.75e-08	-0.272000	1.75e-07
Separation of Sister Chromatids	166	1.49e-09	0.272000	1.75e-08
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	44	1.84e-03	-0.271000	6.84e-03
RNA Polymerase I Promoter Escape	40	3.06e-03	0.271000	9.93e-03
Pre-NOTCH Processing in Golgi	18	4.71e-02	-0.270000	9.68e-02
Methylation	13	9.19e-02	0.270000	1.64e-01
Activation of kainate receptors upon glutamate binding	24	2.22e-02	-0.270000	5.24e-02
RNA Polymerase I Transcription Termination	30	1.07e-02	0.269000	2.87e-02
NCAM signaling for neurite out-growth	50	1.00e-03	-0.269000	4.06e-03
MAPK targets/ Nuclear events mediated by MAP kinases	31	9.59e-03	-0.269000	2.62e-02
Synthesis of IP3 and IP4 in the cytosol	24	2.27e-02	-0.269000	5.34e-02
MECP2 regulates neuronal receptors and channels	15	7.17e-02	-0.269000	1.32e-01
Interleukin-15 signaling	14	8.19e-02	-0.269000	1.48e-01
VEGFR2 mediated vascular permeability	27	1.60e-02	-0.268000	4.02e-02
PCNA-Dependent Long Patch Base Excision Repair	21	3.48e-02	0.266000	7.60e-02
Base Excision Repair	52	9.24e-04	0.266000	3.82e-03
Activation of the pre-replicative complex	31	1.05e-02	0.265000	2.85e-02
G1/S-Specific Transcription	28	1.51e-02	0.265000	3.82e-02
Ion transport by P-type ATPases	41	3.38e-03	-0.265000	1.08e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	1.48e-01	0.264000	2.42e-01
tRNA modification in the nucleus and cytosol	43	2.75e-03	0.264000	9.17e-03
HIV Transcription Initiation	45	2.20e-03	0.264000	7.85e-03
RNA Polymerase II HIV Promoter Escape	45	2.20e-03	0.264000	7.85e-03
RNA Polymerase II Promoter Escape	45	2.20e-03	0.264000	7.85e-03
RNA Polymerase II Transcription Initiation	45	2.20e-03	0.264000	7.85e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	2.20e-03	0.264000	7.85e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	2.20e-03	0.264000	7.85e-03
Cleavage of the damaged pyrimidine	22	3.23e-02	0.264000	7.16e-02
Depyrimidination	22	3.23e-02	0.264000	7.16e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	22	3.23e-02	0.264000	7.16e-02
mRNA 3’-end processing	56	6.42e-04	0.264000	2.81e-03
RHO GTPase cycle	426	1.14e-20	-0.263000	5.31e-19
Neurexins and neuroligins	47	1.78e-03	-0.263000	6.70e-03
Metabolism of porphyrins	21	3.67e-02	0.263000	7.94e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	27	1.79e-02	-0.263000	4.41e-02
Constitutive Signaling by Overexpressed ERBB2	11	1.31e-01	-0.263000	2.20e-01
Interleukin-37 signaling	20	4.20e-02	-0.263000	8.92e-02
Collagen biosynthesis and modifying enzymes	62	3.55e-04	0.262000	1.70e-03
Degradation of beta-catenin by the destruction complex	83	3.66e-05	0.262000	2.37e-04
Global Genome Nucleotide Excision Repair (GG-NER)	84	3.33e-05	0.262000	2.23e-04
ROS and RNS production in phagocytes	33	9.26e-03	0.262000	2.54e-02
HDMs demethylate histones	22	3.37e-02	-0.262000	7.38e-02
Synaptic adhesion-like molecules	17	6.27e-02	-0.261000	1.20e-01
Assembly of collagen fibrils and other multimeric structures	53	1.03e-03	0.261000	4.16e-03
EPHB-mediated forward signaling	32	1.07e-02	-0.261000	2.87e-02
Downstream TCR signaling	94	1.29e-05	0.260000	9.03e-05
Activation of gene expression by SREBF (SREBP)	42	3.54e-03	-0.260000	1.11e-02
mRNA Splicing - Minor Pathway	52	1.20e-03	0.260000	4.71e-03
Signaling by NTRK2 (TRKB)	23	3.14e-02	-0.259000	7.04e-02
FOXO-mediated transcription of cell cycle genes	15	8.32e-02	-0.258000	1.50e-01
Pyroptosis	22	3.62e-02	0.258000	7.85e-02
Tight junction interactions	17	6.65e-02	-0.257000	1.24e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	2.95e-02	-0.257000	6.69e-02
Cyclin D associated events in G1	47	2.36e-03	0.256000	8.19e-03
G1 Phase	47	2.36e-03	0.256000	8.19e-03
Formation of the beta-catenin:TCF transactivating complex	39	5.62e-03	-0.256000	1.65e-02
GABA synthesis, release, reuptake and degradation	12	1.26e-01	-0.255000	2.13e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	51	1.65e-03	0.255000	6.26e-03
Cellular response to chemical stress	151	6.69e-08	0.255000	6.24e-07
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	9.98e-02	0.254000	1.76e-01
Formation of Incision Complex in GG-NER	43	4.08e-03	0.253000	1.26e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.02e-01	0.253000	1.79e-01
Interleukin-12 signaling	41	5.18e-03	0.252000	1.55e-02
PERK regulates gene expression	32	1.35e-02	0.252000	3.49e-02
Collagen formation	84	6.50e-05	0.252000	3.98e-04
Cell Cycle Checkpoints	250	6.87e-12	0.252000	1.17e-10
ADORA2B mediated anti-inflammatory cytokines production	73	1.98e-04	-0.252000	1.02e-03
Protein-protein interactions at synapses	70	2.69e-04	-0.252000	1.35e-03
ABC-family proteins mediated transport	94	2.60e-05	0.251000	1.77e-04
Voltage gated Potassium channels	25	2.98e-02	-0.251000	6.74e-02
Regulation of Complement cascade	52	1.80e-03	0.250000	6.74e-03
Senescence-Associated Secretory Phenotype (SASP)	59	9.13e-04	0.250000	3.80e-03
Transmission across Chemical Synapses	183	5.88e-09	-0.250000	6.44e-08
PI-3K cascade:FGFR3	14	1.06e-01	-0.249000	1.86e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	1.46e-04	0.249000	7.85e-04
Phase II - Conjugation of compounds	71	2.98e-04	0.248000	1.46e-03
activated TAK1 mediates p38 MAPK activation	19	6.23e-02	-0.247000	1.19e-01
Cytoprotection by HMOX1	119	3.30e-06	0.247000	2.51e-05
Mitotic G2-G2/M phases	181	1.05e-08	0.247000	1.11e-07
Cell junction organization	65	5.92e-04	-0.246000	2.66e-03
GABA receptor activation	42	5.80e-03	-0.246000	1.68e-02
G2/M Transition	179	1.49e-08	0.245000	1.52e-07
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	1.79e-01	-0.245000	2.83e-01
Chaperone Mediated Autophagy	20	5.85e-02	0.244000	1.14e-01
Listeria monocytogenes entry into host cells	18	7.28e-02	-0.244000	1.34e-01
Signaling by MET	64	7.30e-04	-0.244000	3.17e-03
EPH-ephrin mediated repulsion of cells	46	4.22e-03	-0.244000	1.29e-02
InlB-mediated entry of Listeria monocytogenes into host cell	14	1.15e-01	-0.244000	1.97e-01
Diseases of mitotic cell cycle	38	9.43e-03	0.243000	2.58e-02
Signaling by NOTCH4	81	1.59e-04	0.243000	8.35e-04
Regulation of mRNA stability by proteins that bind AU-rich elements	87	9.34e-05	0.242000	5.49e-04
Neuronal System	277	4.01e-12	-0.242000	7.06e-11
p130Cas linkage to MAPK signaling for integrins	12	1.51e-01	-0.240000	2.45e-01
Amino acids regulate mTORC1	51	3.14e-03	0.239000	1.02e-02
Sphingolipid de novo biosynthesis	38	1.08e-02	-0.239000	2.87e-02
Keratan sulfate/keratin metabolism	33	1.78e-02	0.238000	4.41e-02
Activation of GABAB receptors	33	1.80e-02	-0.238000	4.41e-02
GABA B receptor activation	33	1.80e-02	-0.238000	4.41e-02
Platelet homeostasis	74	4.29e-04	-0.237000	2.00e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	45	6.05e-03	-0.237000	1.74e-02
Nucleotide biosynthesis	12	1.56e-01	0.236000	2.53e-01
DAP12 signaling	28	3.06e-02	-0.236000	6.87e-02
Sema3A PAK dependent Axon repulsion	16	1.03e-01	-0.235000	1.82e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	4.64e-02	-0.235000	9.66e-02
Pre-NOTCH Transcription and Translation	42	8.51e-03	-0.235000	2.36e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.29e-01	0.234000	2.16e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	1.79e-01	-0.234000	2.83e-01
PINK1-PRKN Mediated Mitophagy	21	6.34e-02	0.234000	1.21e-01
Pyruvate metabolism	27	3.56e-02	0.234000	7.73e-02
Keratan sulfate biosynthesis	28	3.25e-02	0.234000	7.20e-02
E2F mediated regulation of DNA replication	22	5.85e-02	0.233000	1.14e-01
CD28 dependent PI3K/Akt signaling	21	6.48e-02	-0.233000	1.22e-01
Signaling by NTRK3 (TRKC)	17	9.80e-02	-0.232000	1.73e-01
FOXO-mediated transcription	57	2.47e-03	-0.232000	8.49e-03
Semaphorin interactions	63	1.47e-03	-0.232000	5.65e-03
Degradation of cysteine and homocysteine	13	1.49e-01	0.231000	2.43e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	12	1.67e-01	-0.231000	2.67e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	4.64e-02	0.230000	9.66e-02
Transcriptional regulation of white adipocyte differentiation	83	2.96e-04	-0.230000	1.46e-03
PI-3K cascade:FGFR2	16	1.12e-01	-0.229000	1.95e-01
Metabolism of RNA	683	2.04e-24	0.229000	1.28e-22
Transcriptional regulation by RUNX2	115	2.25e-05	0.229000	1.55e-04
ESR-mediated signaling	158	6.96e-07	-0.229000	5.78e-06
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.33e-03	-0.229000	1.06e-02
RAB GEFs exchange GTP for GDP on RABs	88	2.08e-04	-0.229000	1.06e-03
Defective B3GALT6 causes EDSP2 and SEMDJL1	18	9.29e-02	-0.229000	1.65e-01
Chromosome Maintenance	97	1.02e-04	0.228000	5.87e-04
G alpha (s) signalling events	85	2.80e-04	-0.228000	1.39e-03
Sulfur amino acid metabolism	25	4.90e-02	0.227000	9.91e-02
Downregulation of ERBB2 signaling	26	4.47e-02	-0.227000	9.39e-02
Prolactin receptor signaling	11	1.93e-01	-0.227000	3.00e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	4.99e-02	0.227000	1.00e-01
Glycogen metabolism	26	4.56e-02	0.227000	9.54e-02
Regulation of TP53 Activity through Acetylation	29	3.54e-02	-0.226000	7.70e-02
FGFR2 mutant receptor activation	26	4.72e-02	0.225000	9.68e-02
Nucleotide Excision Repair	110	5.12e-05	0.224000	3.26e-04
Mitotic Anaphase	223	9.75e-09	0.223000	1.04e-07
Plasma lipoprotein assembly	12	1.81e-01	-0.223000	2.86e-01
Dual Incision in GG-NER	41	1.39e-02	0.222000	3.56e-02
Signaling by NTRKs	126	1.75e-05	-0.222000	1.22e-04
Mitotic Metaphase and Anaphase	224	1.12e-08	0.222000	1.17e-07
Hedgehog ‘on’ state	82	5.39e-04	0.221000	2.45e-03
SHC1 events in EGFR signaling	12	1.85e-01	-0.221000	2.90e-01
TRAF6 mediated IRF7 activation	16	1.26e-01	-0.221000	2.13e-01
RHO GTPases activate CIT	19	9.66e-02	-0.220000	1.71e-01
G alpha (q) signalling events	144	5.20e-06	-0.220000	3.85e-05
Sealing of the nuclear envelope (NE) by ESCRT-III	26	5.22e-02	0.220000	1.03e-01
Glucose metabolism	83	5.34e-04	0.220000	2.43e-03
Assembly and cell surface presentation of NMDA receptors	21	8.13e-02	-0.220000	1.47e-01
Beta-catenin phosphorylation cascade	17	1.17e-01	-0.219000	2.01e-01
Activation of Matrix Metalloproteinases	24	6.39e-02	0.219000	1.21e-01
PCP/CE pathway	88	4.07e-04	0.218000	1.90e-03
Signaling by NOTCH3	46	1.06e-02	-0.218000	2.85e-02
SUMOylation of transcription factors	17	1.20e-01	-0.218000	2.05e-01
The role of Nef in HIV-1 replication and disease pathogenesis	27	5.05e-02	-0.217000	1.01e-01
EPH-Ephrin signaling	87	4.80e-04	-0.217000	2.21e-03
Complement cascade	57	4.70e-03	0.216000	1.43e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	5.64e-02	-0.216000	1.10e-01
Carnitine metabolism	12	1.96e-01	-0.216000	3.03e-01
Circadian Clock	66	2.49e-03	-0.215000	8.53e-03
Josephin domain DUBs	10	2.39e-01	0.215000	3.53e-01
Signaling by TGFB family members	97	2.89e-04	-0.213000	1.43e-03
Trafficking of GluR2-containing AMPA receptors	13	1.84e-01	-0.213000	2.90e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	1.73e-02	0.212000	4.30e-02
HIV Transcription Elongation	42	1.73e-02	0.212000	4.30e-02
Tat-mediated elongation of the HIV-1 transcript	42	1.73e-02	0.212000	4.30e-02
TBC/RABGAPs	44	1.49e-02	-0.212000	3.78e-02
Platelet Aggregation (Plug Formation)	31	4.10e-02	-0.212000	8.75e-02
Processive synthesis on the lagging strand	15	1.56e-01	0.212000	2.52e-01
Downstream signaling of activated FGFR4	21	9.42e-02	-0.211000	1.67e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	3.56e-03	0.211000	1.12e-02
RHO GTPases activate IQGAPs	10	2.49e-01	-0.211000	3.63e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	13	1.90e-01	-0.210000	2.97e-01
Pre-NOTCH Expression and Processing	58	5.77e-03	-0.210000	1.68e-02
MAP2K and MAPK activation	35	3.22e-02	-0.209000	7.16e-02
Nuclear Receptor transcription pathway	41	2.12e-02	-0.208000	5.05e-02
Maturation of nucleoprotein	11	2.33e-01	-0.208000	3.47e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	2.56e-01	0.207000	3.73e-01
Telomere Maintenance	72	2.40e-03	0.207000	8.27e-03
Interleukin-10 signaling	35	3.42e-02	0.207000	7.48e-02
XBP1(S) activates chaperone genes	47	1.42e-02	0.207000	3.64e-02
IRE1alpha activates chaperones	49	1.25e-02	0.206000	3.26e-02
Signaling by TGF-beta Receptor Complex	73	2.31e-03	-0.206000	8.08e-03
RHO GTPases activate PKNs	40	2.41e-02	-0.206000	5.62e-02
Signaling by NOTCH2	31	4.75e-02	-0.206000	9.70e-02
DNA methylation	13	1.99e-01	0.206000	3.08e-01
Extension of Telomeres	49	1.28e-02	0.205000	3.35e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	1.44e-01	0.205000	2.36e-01
Cellular hexose transport	14	1.85e-01	0.205000	2.90e-01
Translocation of ZAP-70 to Immunological synapse	19	1.24e-01	0.204000	2.10e-01
Inositol phosphate metabolism	45	1.79e-02	-0.204000	4.41e-02
Polo-like kinase mediated events	15	1.71e-01	0.204000	2.73e-01
Receptor-type tyrosine-protein phosphatases	14	1.87e-01	-0.204000	2.92e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	2.43e-01	0.204000	3.56e-01
VLDLR internalisation and degradation	11	2.44e-01	-0.203000	3.58e-01
Signaling by NOTCH1	72	2.91e-03	-0.203000	9.63e-03
Sema4D induced cell migration and growth-cone collapse	20	1.16e-01	-0.203000	2.00e-01
Receptor Mediated Mitophagy	11	2.45e-01	-0.202000	3.59e-01
Sensory processing of sound by outer hair cells of the cochlea	40	2.70e-02	-0.202000	6.19e-02
WNT5A-dependent internalization of FZD4	14	1.91e-01	-0.202000	2.98e-01
Vitamin B5 (pantothenate) metabolism	17	1.51e-01	0.201000	2.45e-01
Pentose phosphate pathway	13	2.09e-01	0.201000	3.19e-01
Rab regulation of trafficking	120	1.41e-04	-0.201000	7.63e-04
Unwinding of DNA	12	2.28e-01	0.201000	3.41e-01
Signaling by Non-Receptor Tyrosine Kinases	50	1.43e-02	-0.200000	3.65e-02
Signaling by PTK6	50	1.43e-02	-0.200000	3.65e-02
Miscellaneous transport and binding events	21	1.14e-01	-0.199000	1.97e-01
Defective B4GALT7 causes EDS, progeroid type	18	1.44e-01	-0.199000	2.36e-01
CLEC7A (Dectin-1) signaling	95	8.48e-04	0.198000	3.59e-03
Caspase-mediated cleavage of cytoskeletal proteins	12	2.35e-01	-0.198000	3.49e-01
Metabolism of Angiotensinogen to Angiotensins	15	1.85e-01	0.198000	2.90e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	1.47e-01	-0.198000	2.40e-01
Signaling by the B Cell Receptor (BCR)	124	1.45e-04	0.198000	7.82e-04
MAPK6/MAPK4 signaling	84	1.78e-03	0.197000	6.70e-03
Signaling by NTRK1 (TRKA)	109	3.80e-04	-0.197000	1.80e-03
Hedgehog ‘off’ state	96	9.28e-04	0.196000	3.82e-03
Glycolysis	66	6.24e-03	0.195000	1.78e-02
Unfolded Protein Response (UPR)	89	1.50e-03	0.195000	5.74e-03
Cell-cell junction organization	40	3.35e-02	-0.194000	7.36e-02
mRNA Splicing	187	4.92e-06	0.194000	3.66e-05
Signaling by FGFR3 in disease	18	1.58e-01	-0.192000	2.55e-01
Signaling by FGFR3 point mutants in cancer	18	1.58e-01	-0.192000	2.55e-01
Cell death signalling via NRAGE, NRIF and NADE	74	4.28e-03	-0.192000	1.30e-02
Mismatch Repair	15	1.98e-01	0.192000	3.06e-01
Uptake and actions of bacterial toxins	24	1.04e-01	-0.192000	1.83e-01
Termination of translesion DNA synthesis	31	6.48e-02	0.192000	1.22e-01
Signaling by Nuclear Receptors	220	9.95e-07	-0.192000	8.12e-06
DNA strand elongation	32	6.11e-02	0.191000	1.17e-01
Dual incision in TC-NER	65	7.78e-03	0.191000	2.18e-02
Defective B3GAT3 causes JDSSDHD	18	1.61e-01	-0.191000	2.59e-01
HS-GAG degradation	21	1.30e-01	-0.191000	2.18e-01
Host Interactions of HIV factors	128	1.98e-04	0.191000	1.02e-03
mRNA Splicing - Major Pathway	179	1.18e-05	0.190000	8.32e-05
G0 and Early G1	26	9.46e-02	0.189000	1.68e-01
Early Phase of HIV Life Cycle	14	2.21e-01	0.189000	3.33e-01
Activation of G protein gated Potassium channels	20	1.44e-01	-0.189000	2.36e-01
G protein gated Potassium channels	20	1.44e-01	-0.189000	2.36e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	1.44e-01	-0.189000	2.36e-01
FRS-mediated FGFR4 signaling	16	1.92e-01	-0.188000	2.99e-01
Glutamate and glutamine metabolism	13	2.41e-01	0.188000	3.55e-01
Binding and Uptake of Ligands by Scavenger Receptors	52	1.93e-02	0.188000	4.71e-02
MET activates RAS signaling	11	2.83e-01	-0.187000	4.05e-01
Mitotic Spindle Checkpoint	107	8.42e-04	0.187000	3.58e-03
Dopamine Neurotransmitter Release Cycle	21	1.40e-01	-0.186000	2.32e-01
Sensory processing of sound by inner hair cells of the cochlea	52	2.08e-02	-0.185000	4.98e-02
Lagging Strand Synthesis	20	1.51e-01	0.185000	2.46e-01
Xenobiotics	10	3.11e-01	-0.185000	4.39e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	5.13e-02	0.185000	1.02e-01
Negative regulation of FLT3	15	2.16e-01	-0.185000	3.27e-01
SUMOylation of transcription cofactors	44	3.46e-02	-0.184000	7.57e-02
SUMO E3 ligases SUMOylate target proteins	162	5.35e-05	-0.184000	3.38e-04
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	2.18e-01	-0.184000	3.31e-01
Regulation of lipid metabolism by PPARalpha	108	1.06e-03	-0.182000	4.26e-03
Triglyceride catabolism	16	2.09e-01	-0.181000	3.19e-01
Integrin signaling	24	1.24e-01	-0.181000	2.10e-01
Transcriptional activation of mitochondrial biogenesis	52	2.38e-02	-0.181000	5.54e-02
Class B/2 (Secretin family receptors)	59	1.60e-02	-0.181000	4.03e-02
Cardiac conduction	93	2.57e-03	-0.181000	8.77e-03
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	2.11e-01	-0.181000	3.21e-01
Sensory processing of sound	57	1.85e-02	-0.180000	4.53e-02
p75 NTR receptor-mediated signalling	93	2.68e-03	-0.180000	8.98e-03
Abortive elongation of HIV-1 transcript in the absence of Tat	23	1.35e-01	0.180000	2.24e-01
Signaling by Rho GTPases	602	5.92e-14	-0.179000	1.32e-12
Phospholipid metabolism	186	2.66e-05	-0.179000	1.81e-04
Glyoxylate metabolism and glycine degradation	23	1.39e-01	0.178000	2.30e-01
Processing of Capped Intron-Containing Pre-mRNA	238	2.32e-06	0.178000	1.79e-05
Removal of the Flap Intermediate	14	2.49e-01	0.178000	3.63e-01
Interleukin-1 family signaling	125	5.97e-04	0.178000	2.67e-03
Phase 0 - rapid depolarisation	24	1.32e-01	-0.178000	2.20e-01
ATF6 (ATF6-alpha) activates chaperones	12	2.87e-01	0.178000	4.10e-01
Defective pyroptosis	22	1.50e-01	0.177000	2.44e-01
Keratinization	30	9.34e-02	-0.177000	1.66e-01
Ion homeostasis	42	4.72e-02	-0.177000	9.68e-02
Beta-oxidation of very long chain fatty acids	10	3.33e-01	0.177000	4.64e-01
GPCR downstream signalling	402	1.23e-09	-0.177000	1.47e-08
SUMOylation	168	7.80e-05	-0.177000	4.68e-04
Platelet sensitization by LDL	17	2.07e-01	-0.177000	3.18e-01
Cellular responses to stress	662	1.05e-14	0.177000	2.72e-13
PPARA activates gene expression	106	1.70e-03	-0.177000	6.43e-03
Formation of HIV elongation complex in the absence of HIV Tat	44	4.32e-02	0.176000	9.13e-02
Cellular responses to stimuli	672	8.53e-15	0.176000	2.24e-13
Ovarian tumor domain proteases	38	6.16e-02	-0.175000	1.18e-01
LDL clearance	18	1.98e-01	-0.175000	3.07e-01
TCR signaling	115	1.19e-03	0.175000	4.67e-03
Metabolism of nitric oxide: NOS3 activation and regulation	15	2.41e-01	-0.175000	3.55e-01
Late endosomal microautophagy	31	9.26e-02	0.175000	1.65e-01
Estrogen-dependent gene expression	95	3.46e-03	-0.174000	1.09e-02
Transport of Mature Transcript to Cytoplasm	81	7.05e-03	0.173000	2.00e-02
COPI-dependent Golgi-to-ER retrograde traffic	76	9.14e-03	0.173000	2.52e-02
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	618	2.52e-13	-0.173000	5.28e-12
Interleukin-12 family signaling	48	3.86e-02	0.173000	8.30e-02
DNA Repair	283	5.99e-07	0.173000	5.01e-06
Signalling to ERKs	33	8.74e-02	-0.172000	1.57e-01
Processing of Capped Intronless Pre-mRNA	28	1.16e-01	0.172000	1.99e-01
Neurotransmitter release cycle	39	6.36e-02	-0.172000	1.21e-01
Deadenylation of mRNA	22	1.65e-01	-0.171000	2.64e-01
Regulation of FZD by ubiquitination	17	2.27e-01	-0.169000	3.40e-01
SHC-mediated cascade:FGFR1	14	2.74e-01	-0.169000	3.96e-01
SIRT1 negatively regulates rRNA expression	17	2.28e-01	0.169000	3.41e-01
Regulation of gene expression by Hypoxia-inducible Factor	10	3.56e-01	-0.169000	4.88e-01
Activation of BAD and translocation to mitochondria	15	2.59e-01	-0.168000	3.76e-01
Downstream signaling of activated FGFR3	21	1.82e-01	-0.168000	2.87e-01
Insulin processing	24	1.55e-01	-0.168000	2.52e-01
Plasma lipoprotein assembly, remodeling, and clearance	54	3.34e-02	-0.167000	7.35e-02
Signaling by GPCR	447	1.42e-09	-0.167000	1.68e-08
Cleavage of the damaged purine	17	2.33e-01	0.167000	3.47e-01
Depurination	17	2.33e-01	0.167000	3.47e-01
Recognition and association of DNA glycosylase with site containing an affected purine	17	2.33e-01	0.167000	3.47e-01
Signaling by Receptor Tyrosine Kinases	466	7.18e-10	-0.167000	8.71e-09
Effects of PIP2 hydrolysis	24	1.57e-01	-0.167000	2.54e-01
ERKs are inactivated	13	2.99e-01	-0.166000	4.25e-01
Diseases of signal transduction by growth factor receptors and second messengers	395	1.42e-08	-0.166000	1.46e-07
Protein methylation	15	2.65e-01	0.166000	3.84e-01
p75NTR recruits signalling complexes	13	3.00e-01	0.166000	4.26e-01
Collagen chain trimerization	40	6.94e-02	0.166000	1.28e-01
TP53 Regulates Transcription of Cell Death Genes	41	6.70e-02	0.165000	1.24e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	2.39e-01	0.165000	3.53e-01
Assembly of the ORC complex at the origin of replication	18	2.25e-01	0.165000	3.39e-01
Neddylation	220	2.51e-05	0.165000	1.72e-04
NOTCH1 Intracellular Domain Regulates Transcription	47	5.05e-02	-0.165000	1.01e-01
HDR through Homologous Recombination (HRR)	66	2.09e-02	0.164000	4.98e-02
Phospholipase C-mediated cascade; FGFR2	11	3.45e-01	0.164000	4.80e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	2.16e-01	-0.164000	3.28e-01
Plasma lipoprotein clearance	29	1.27e-01	-0.164000	2.14e-01
Processing of DNA double-strand break ends	65	2.25e-02	0.164000	5.29e-02
PRC2 methylates histones and DNA	22	1.84e-01	0.163000	2.90e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	3.72e-01	0.163000	5.00e-01
Homology Directed Repair	104	4.10e-03	0.163000	1.26e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	98	5.44e-03	0.163000	1.61e-02
Meiotic recombination	29	1.31e-01	0.162000	2.20e-01
Disorders of transmembrane transporters	141	9.26e-04	0.162000	3.82e-03
tRNA processing in the nucleus	59	3.19e-02	0.162000	7.12e-02
Synthesis of IP2, IP, and Ins in the cytosol	13	3.13e-01	-0.161000	4.43e-01
Downstream signaling of activated FGFR2	23	1.80e-01	-0.161000	2.85e-01
Activation of BH3-only proteins	29	1.33e-01	-0.161000	2.21e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.79e-02	0.161000	4.41e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	2.65e-01	0.161000	3.84e-01
Transcriptional regulation by RUNX3	94	7.15e-03	0.161000	2.03e-02
Signaling by FGFR1	42	7.35e-02	-0.160000	1.35e-01
Cytosolic sulfonation of small molecules	19	2.30e-01	0.159000	3.43e-01
Leishmania infection	204	9.13e-05	-0.159000	5.38e-04
HSF1-dependent transactivation	32	1.22e-01	-0.158000	2.08e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	1.35e-01	-0.158000	2.24e-01
Caspase activation via extrinsic apoptotic signalling pathway	23	1.93e-01	0.157000	3.00e-01
Chromatin modifying enzymes	208	1.03e-04	-0.156000	5.91e-04
Chromatin organization	208	1.03e-04	-0.156000	5.91e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	116	3.75e-03	0.156000	1.17e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	11	3.72e-01	0.156000	5.00e-01
Signaling by ALK fusions and activated point mutants	55	4.66e-02	-0.155000	9.67e-02
Signaling by ALK in cancer	55	4.66e-02	-0.155000	9.67e-02
Clathrin-mediated endocytosis	131	2.22e-03	-0.155000	7.91e-03
HIV Infection	224	6.72e-05	0.155000	4.06e-04
RAF-independent MAPK1/3 activation	22	2.10e-01	-0.154000	3.20e-01
Golgi Associated Vesicle Biogenesis	55	4.80e-02	-0.154000	9.71e-02
TNFs bind their physiological receptors	23	2.01e-01	0.154000	3.09e-01
Potassium Channels	63	3.53e-02	-0.153000	7.69e-02
Apoptotic execution phase	45	7.53e-02	-0.153000	1.38e-01
Apoptotic cleavage of cellular proteins	35	1.17e-01	-0.153000	2.01e-01
Programmed Cell Death	190	2.77e-04	0.153000	1.38e-03
RAF activation	33	1.29e-01	-0.153000	2.16e-01
Diseases of carbohydrate metabolism	29	1.55e-01	0.152000	2.52e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	1.36e-01	-0.152000	2.27e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	44	8.10e-02	-0.152000	1.47e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	2.18e-01	0.152000	3.30e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	23	2.08e-01	-0.152000	3.18e-01
Trafficking of AMPA receptors	23	2.08e-01	-0.152000	3.18e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	4.78e-02	-0.152000	9.70e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	4.78e-02	-0.152000	9.70e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	4.78e-02	-0.152000	9.70e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	4.78e-02	-0.152000	9.70e-02
Signaling by NOTCH1 in Cancer	57	4.78e-02	-0.152000	9.70e-02
Intra-Golgi traffic	43	8.66e-02	-0.151000	1.55e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	2.81e-01	0.151000	4.04e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	2.81e-01	0.151000	4.04e-01
TRAF6 mediated NF-kB activation	24	2.01e-01	-0.151000	3.10e-01
Long-term potentiation	17	2.82e-01	-0.151000	4.05e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	3.48e-01	-0.150000	4.82e-01
Metabolism	1805	6.97e-26	0.150000	4.58e-24
Inwardly rectifying K+ channels	23	2.16e-01	-0.149000	3.27e-01
Platelet activation, signaling and aggregation	226	1.16e-04	-0.149000	6.51e-04
Signal Transduction	2085	1.67e-28	-0.148000	1.72e-26
SUMOylation of chromatin organization proteins	57	5.34e-02	-0.148000	1.06e-01
Fcgamma receptor (FCGR) dependent phagocytosis	105	9.10e-03	-0.147000	2.52e-02
Nicotinamide salvaging	16	3.08e-01	0.147000	4.37e-01
Inhibition of DNA recombination at telomere	29	1.72e-01	0.147000	2.73e-01
Recognition of DNA damage by PCNA-containing replication complex	30	1.69e-01	0.145000	2.69e-01
Transcription of the HIV genome	67	4.07e-02	0.145000	8.71e-02
Activated point mutants of FGFR2	10	4.29e-01	0.144000	5.57e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.71e-01	0.144000	2.73e-01
MAP kinase activation	63	4.78e-02	-0.144000	9.70e-02
Platelet Adhesion to exposed collagen	10	4.31e-01	-0.144000	5.59e-01
A tetrasaccharide linker sequence is required for GAG synthesis	24	2.23e-01	-0.144000	3.37e-01
Metalloprotease DUBs	19	2.80e-01	0.143000	4.04e-01
Norepinephrine Neurotransmitter Release Cycle	14	3.56e-01	-0.142000	4.88e-01
HCMV Early Events	66	4.70e-02	-0.141000	9.68e-02
Interleukin-17 signaling	67	4.58e-02	-0.141000	9.57e-02
Apoptosis	165	1.80e-03	0.141000	6.74e-03
Signaling by FGFR in disease	55	7.12e-02	-0.141000	1.31e-01
NoRC negatively regulates rRNA expression	55	7.13e-02	0.141000	1.31e-01
IL-6-type cytokine receptor ligand interactions	15	3.47e-01	0.140000	4.81e-01
Nuclear Events (kinase and transcription factor activation)	57	6.76e-02	-0.140000	1.25e-01
Toll Like Receptor 9 (TLR9) Cascade	93	1.99e-02	-0.140000	4.81e-02
Processing and activation of SUMO	10	4.45e-01	0.140000	5.72e-01
Association of TriC/CCT with target proteins during biosynthesis	37	1.43e-01	0.139000	2.36e-01
Assembly of active LPL and LIPC lipase complexes	12	4.06e-01	-0.139000	5.35e-01
DARPP-32 events	23	2.53e-01	-0.138000	3.68e-01
IRAK2 mediated activation of TAK1 complex	10	4.51e-01	-0.138000	5.77e-01
TP53 Regulates Transcription of DNA Repair Genes	61	6.33e-02	0.138000	1.21e-01
Regulation of TNFR1 signaling	35	1.60e-01	0.137000	2.57e-01
Zinc transporters	12	4.10e-01	0.137000	5.40e-01
Cell Cycle, Mitotic	493	1.90e-07	0.137000	1.69e-06
Cargo recognition for clathrin-mediated endocytosis	94	2.17e-02	-0.137000	5.16e-02
Heparan sulfate/heparin (HS-GAG) metabolism	45	1.12e-01	-0.137000	1.95e-01
Adherens junctions interactions	21	2.78e-01	-0.137000	4.01e-01
FGFR2 ligand binding and activation	12	4.12e-01	0.137000	5.41e-01
Vpr-mediated nuclear import of PICs	34	1.68e-01	-0.137000	2.69e-01
SUMOylation of ubiquitinylation proteins	39	1.40e-01	-0.136000	2.32e-01
Budding and maturation of HIV virion	27	2.22e-01	0.136000	3.36e-01
SUMOylation of DNA damage response and repair proteins	77	3.97e-02	-0.136000	8.50e-02
Peroxisomal protein import	57	7.67e-02	0.136000	1.40e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	3.98e-01	-0.135000	5.28e-01
eNOS activation	11	4.38e-01	-0.135000	5.65e-01
Processive synthesis on the C-strand of the telomere	19	3.09e-01	0.135000	4.37e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	33	1.81e-01	-0.135000	2.86e-01
Reduction of cytosolic Ca++ levels	10	4.63e-01	-0.134000	5.90e-01
Role of phospholipids in phagocytosis	44	1.25e-01	0.134000	2.12e-01
Metabolic disorders of biological oxidation enzymes	23	2.68e-01	0.133000	3.87e-01
Meiotic synapsis	35	1.73e-01	-0.133000	2.75e-01
Caspase activation via Death Receptors in the presence of ligand	15	3.72e-01	0.133000	5.00e-01
M Phase	353	1.86e-05	0.133000	1.30e-04
Molecules associated with elastic fibres	28	2.26e-01	-0.132000	3.39e-01
FRS-mediated FGFR3 signaling	16	3.60e-01	-0.132000	4.91e-01
Diseases of programmed cell death	49	1.10e-01	0.132000	1.92e-01
COPI-mediated anterograde transport	79	4.33e-02	0.132000	9.13e-02
Negative regulation of FGFR1 signaling	26	2.46e-01	-0.132000	3.59e-01
Diseases associated with the TLR signaling cascade	27	2.39e-01	-0.131000	3.53e-01
Diseases of Immune System	27	2.39e-01	-0.131000	3.53e-01
NS1 Mediated Effects on Host Pathways	40	1.55e-01	-0.130000	2.51e-01
Platelet calcium homeostasis	23	2.81e-01	-0.130000	4.04e-01
Factors involved in megakaryocyte development and platelet production	109	1.93e-02	-0.130000	4.71e-02
Sphingolipid metabolism	76	5.08e-02	-0.130000	1.01e-01
NRIF signals cell death from the nucleus	16	3.70e-01	0.129000	4.99e-01
Cell Cycle	608	5.43e-08	0.129000	5.20e-07
Mucopolysaccharidoses	11	4.58e-01	-0.129000	5.85e-01
AKT phosphorylates targets in the cytosol	14	4.04e-01	-0.129000	5.34e-01
Costimulation by the CD28 family	65	7.29e-02	-0.129000	1.34e-01
Infection with Mycobacterium tuberculosis	27	2.49e-01	0.128000	3.63e-01
FRS-mediated FGFR2 signaling	18	3.49e-01	-0.128000	4.82e-01
Asparagine N-linked glycosylation	272	3.18e-04	0.127000	1.54e-03
Export of Viral Ribonucleoproteins from Nucleus	33	2.07e-01	-0.127000	3.18e-01
Acyl chain remodelling of PG	11	4.67e-01	0.127000	5.94e-01
Elevation of cytosolic Ca2+ levels	13	4.29e-01	-0.127000	5.57e-01
Signaling by EGFR in Cancer	23	2.94e-01	-0.126000	4.20e-01
Transcriptional regulation of granulopoiesis	36	1.91e-01	-0.126000	2.98e-01
DAP12 interactions	38	1.80e-01	-0.126000	2.85e-01
Serotonin Neurotransmitter Release Cycle	16	3.85e-01	-0.125000	5.14e-01
RHO GTPases activate KTN1	10	5.00e-01	-0.123000	6.24e-01
RNA Polymerase III Chain Elongation	18	3.65e-01	0.123000	4.96e-01
Death Receptor Signalling	136	1.34e-02	-0.123000	3.46e-02
Removal of the Flap Intermediate from the C-strand	17	3.81e-01	0.123000	5.10e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	88	4.70e-02	-0.123000	9.68e-02
IRAK1 recruits IKK complex	10	5.04e-01	-0.122000	6.26e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	5.04e-01	-0.122000	6.26e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	90	4.56e-02	-0.122000	9.54e-02
Diseases of glycosylation	129	1.75e-02	0.121000	4.34e-02
Response to metal ions	10	5.07e-01	0.121000	6.28e-01
MyD88 cascade initiated on plasma membrane	82	5.88e-02	-0.121000	1.14e-01
Toll Like Receptor 10 (TLR10) Cascade	82	5.88e-02	-0.121000	1.14e-01
Toll Like Receptor 5 (TLR5) Cascade	82	5.88e-02	-0.121000	1.14e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	4.70e-01	0.120000	5.96e-01
alpha-linolenic acid (ALA) metabolism	12	4.70e-01	0.120000	5.96e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	3.64e-01	-0.120000	4.95e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	3.64e-01	-0.120000	4.95e-01
Sensory Perception	150	1.14e-02	-0.120000	3.01e-02
Anti-inflammatory response favouring Leishmania parasite infection	124	2.19e-02	-0.119000	5.18e-02
Leishmania parasite growth and survival	124	2.19e-02	-0.119000	5.18e-02
IRF3-mediated induction of type I IFN	12	4.75e-01	0.119000	6.01e-01
RHOBTB1 GTPase cycle	23	3.23e-01	-0.119000	4.54e-01
DNA Damage Bypass	46	1.65e-01	0.118000	2.64e-01
CRMPs in Sema3A signaling	15	4.28e-01	-0.118000	5.56e-01
Signaling by FGFR4	35	2.27e-01	-0.118000	3.40e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	90	5.47e-02	0.117000	1.07e-01
Amplification of signal from the kinetochores	90	5.47e-02	0.117000	1.07e-01
MyD88 dependent cascade initiated on endosome	89	5.72e-02	-0.117000	1.11e-01
Intracellular signaling by second messengers	283	7.50e-04	-0.117000	3.25e-03
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	20	3.67e-01	-0.117000	4.96e-01
RNA Polymerase I Promoter Clearance	59	1.22e-01	0.116000	2.08e-01
RNA Polymerase I Transcription	59	1.22e-01	0.116000	2.08e-01
Fatty acid metabolism	147	1.53e-02	0.116000	3.86e-02
Endogenous sterols	21	3.58e-01	-0.116000	4.89e-01
COPII-mediated vesicle transport	65	1.07e-01	0.116000	1.88e-01
Rap1 signalling	14	4.57e-01	-0.115000	5.84e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	5.11e-01	-0.114000	6.30e-01
SUMOylation of SUMOylation proteins	35	2.46e-01	-0.113000	3.59e-01
DNA Double-Strand Break Repair	132	2.50e-02	0.113000	5.79e-02
TNFR1-induced proapoptotic signaling	13	4.81e-01	0.113000	6.06e-01
Gap junction degradation	10	5.37e-01	0.113000	6.52e-01
VEGFR2 mediated cell proliferation	19	3.98e-01	-0.112000	5.28e-01
Synthesis of very long-chain fatty acyl-CoAs	21	3.75e-01	-0.112000	5.03e-01
Metabolism of folate and pterines	17	4.26e-01	0.111000	5.56e-01
Fc epsilon receptor (FCERI) signaling	145	2.06e-02	0.111000	4.93e-02
Metabolism of carbohydrates	261	1.96e-03	0.111000	7.25e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	3.09e-01	0.111000	4.38e-01
Signaling by WNT	252	2.44e-03	-0.111000	8.41e-03
Cytochrome c-mediated apoptotic response	13	4.90e-01	0.111000	6.15e-01
Homologous DNA Pairing and Strand Exchange	42	2.15e-01	0.111000	3.27e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	4.92e-01	0.110000	6.16e-01
PD-1 signaling	23	3.60e-01	0.110000	4.91e-01
HDR through MMEJ (alt-NHEJ)	10	5.47e-01	-0.110000	6.61e-01
Negative epigenetic regulation of rRNA expression	58	1.48e-01	0.110000	2.42e-01
NCAM1 interactions	30	3.02e-01	-0.109000	4.29e-01
Metabolism of proteins	1681	1.82e-13	0.109000	3.86e-12
Triglyceride metabolism	25	3.51e-01	-0.108000	4.85e-01
Phase I - Functionalization of compounds	71	1.17e-01	-0.108000	2.01e-01
RNA Polymerase I Transcription Initiation	47	2.02e-01	0.108000	3.11e-01
Post-translational modification: synthesis of GPI-anchored proteins	64	1.38e-01	0.107000	2.29e-01
Golgi-to-ER retrograde transport	109	5.35e-02	0.107000	1.06e-01
N-glycan antennae elongation in the medial/trans-Golgi	21	3.97e-01	-0.107000	5.27e-01
Sensory perception of taste	20	4.09e-01	-0.107000	5.39e-01
The activation of arylsulfatases	10	5.60e-01	-0.106000	6.71e-01
N-Glycan antennae elongation	13	5.07e-01	-0.106000	6.28e-01
Telomere C-strand (Lagging Strand) Synthesis	34	2.84e-01	0.106000	4.07e-01
RHOBTB GTPase Cycle	35	2.78e-01	-0.106000	4.01e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	3.02e-01	-0.105000	4.29e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	30	3.21e-01	0.105000	4.51e-01
Antiviral mechanism by IFN-stimulated genes	80	1.09e-01	-0.104000	1.91e-01
Plasma lipoprotein remodeling	21	4.12e-01	-0.103000	5.41e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	96	8.03e-02	-0.103000	1.46e-01
Toll Like Receptor 2 (TLR2) Cascade	96	8.03e-02	-0.103000	1.46e-01
Toll Like Receptor TLR1:TLR2 Cascade	96	8.03e-02	-0.103000	1.46e-01
Toll Like Receptor TLR6:TLR2 Cascade	96	8.03e-02	-0.103000	1.46e-01
C-type lectin receptors (CLRs)	122	4.97e-02	0.103000	1.00e-01
Eicosanoid ligand-binding receptors	14	5.05e-01	-0.103000	6.26e-01
FCGR3A-mediated phagocytosis	79	1.14e-01	-0.103000	1.97e-01
Leishmania phagocytosis	79	1.14e-01	-0.103000	1.97e-01
Parasite infection	79	1.14e-01	-0.103000	1.97e-01
Diseases of metabolism	206	1.12e-02	0.103000	2.98e-02
Syndecan interactions	20	4.28e-01	-0.102000	5.56e-01
The NLRP3 inflammasome	16	4.80e-01	-0.102000	6.06e-01
Incretin synthesis, secretion, and inactivation	14	5.10e-01	0.102000	6.30e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	5.10e-01	0.102000	6.30e-01
Interferon gamma signaling	83	1.10e-01	-0.101000	1.92e-01
Basigin interactions	23	4.01e-01	0.101000	5.30e-01
Synthesis of PA	31	3.31e-01	-0.101000	4.63e-01
Downregulation of ERBB2:ERBB3 signaling	12	5.46e-01	-0.101000	6.61e-01
Acetylcholine Neurotransmitter Release Cycle	12	5.48e-01	-0.100000	6.61e-01
Response of Mtb to phagocytosis	23	4.06e-01	0.100000	5.35e-01
Packaging Of Telomere Ends	14	5.17e-01	0.100000	6.35e-01
Signaling by ALK	27	3.69e-01	-0.099800	4.98e-01
HCMV Infection	89	1.04e-01	-0.099700	1.83e-01
ER to Golgi Anterograde Transport	130	5.01e-02	0.099600	1.01e-01
Dectin-2 family	14	5.24e-01	-0.098400	6.40e-01
Endosomal/Vacuolar pathway	11	5.72e-01	-0.098400	6.83e-01
Retrograde neurotrophin signalling	14	5.25e-01	-0.098100	6.41e-01
Scavenging by Class A Receptors	18	4.75e-01	-0.097300	6.01e-01
PTEN Regulation	137	5.04e-02	0.096900	1.01e-01
Interleukin-20 family signaling	16	5.02e-01	-0.096800	6.26e-01
Intraflagellar transport	39	2.99e-01	0.096200	4.25e-01
Mitophagy	28	3.79e-01	0.096000	5.08e-01
Nicotinate metabolism	27	3.88e-01	0.095900	5.17e-01
Depolymerisation of the Nuclear Lamina	15	5.20e-01	-0.095900	6.37e-01
Transport of vitamins, nucleosides, and related molecules	31	3.56e-01	0.095900	4.88e-01
Membrane Trafficking	570	1.02e-04	-0.095400	5.87e-04
Peroxisomal lipid metabolism	26	4.01e-01	0.095200	5.30e-01
Regulation of TLR by endogenous ligand	15	5.27e-01	0.094400	6.42e-01
Nuclear Envelope Breakdown	53	2.35e-01	-0.094300	3.49e-01
Cytochrome P450 - arranged by substrate type	36	3.28e-01	-0.094300	4.58e-01
Pausing and recovery of Tat-mediated HIV elongation	30	3.75e-01	0.093700	5.02e-01
Tat-mediated HIV elongation arrest and recovery	30	3.75e-01	0.093700	5.02e-01
Hemostasis	503	3.49e-04	-0.093300	1.67e-03
Presynaptic phase of homologous DNA pairing and strand exchange	39	3.15e-01	0.093000	4.45e-01
Peptide ligand-binding receptors	94	1.20e-01	0.092900	2.04e-01
EML4 and NUDC in mitotic spindle formation	94	1.23e-01	0.092100	2.08e-01
Biological oxidations	146	5.52e-02	0.092000	1.08e-01
Fatty acyl-CoA biosynthesis	33	3.63e-01	-0.091600	4.93e-01
MicroRNA (miRNA) biogenesis	24	4.38e-01	0.091400	5.65e-01
Resolution of D-Loop Structures	33	3.68e-01	0.090600	4.97e-01
RAB geranylgeranylation	60	2.26e-01	-0.090300	3.39e-01
The canonical retinoid cycle in rods (twilight vision)	14	5.59e-01	0.090300	6.71e-01
Common Pathway of Fibrin Clot Formation	10	6.21e-01	-0.090300	7.23e-01
Hyaluronan uptake and degradation	11	6.05e-01	-0.090100	7.14e-01
Metal ion SLC transporters	20	4.88e-01	0.089500	6.13e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	16	5.36e-01	-0.089300	6.52e-01
RNA Polymerase III Transcription Initiation	36	3.55e-01	0.089200	4.88e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	14	5.65e-01	0.088900	6.76e-01
Potential therapeutics for SARS	81	1.68e-01	-0.088500	2.69e-01
G alpha (i) signalling events	199	3.28e-02	-0.087800	7.26e-02
Advanced glycosylation endproduct receptor signaling	12	5.99e-01	0.087800	7.07e-01
Diseases associated with glycosaminoglycan metabolism	39	3.46e-01	0.087300	4.80e-01
Inflammasomes	21	4.94e-01	-0.086200	6.18e-01
Transcription of E2F targets under negative control by DREAM complex	19	5.18e-01	0.085700	6.35e-01
Regulation of actin dynamics for phagocytic cup formation	81	1.85e-01	-0.085300	2.90e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	13	5.94e-01	-0.085300	7.03e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.43e-01	0.085300	5.71e-01
Lysine catabolism	12	6.09e-01	0.085200	7.17e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	5.84e-01	0.084600	6.95e-01
Chondroitin sulfate/dermatan sulfate metabolism	47	3.20e-01	-0.083900	4.50e-01
RNA Polymerase II Pre-transcription Events	78	2.05e-01	0.083100	3.15e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	4.19e-01	-0.082600	5.49e-01
LGI-ADAM interactions	10	6.51e-01	-0.082600	7.48e-01
Role of LAT2/NTAL/LAB on calcium mobilization	29	4.42e-01	0.082500	5.70e-01
TGF-beta receptor signaling activates SMADs	32	4.20e-01	-0.082400	5.49e-01
Aggrephagy	22	5.04e-01	0.082300	6.26e-01
Toll-like Receptor Cascades	147	8.51e-02	-0.082300	1.53e-01
Condensation of Prophase Chromosomes	22	5.04e-01	0.082300	6.26e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	5.35e-01	0.082200	6.51e-01
FCERI mediated MAPK activation	45	3.42e-01	0.081900	4.76e-01
Toll Like Receptor 4 (TLR4) Cascade	126	1.13e-01	-0.081800	1.96e-01
Activation of the AP-1 family of transcription factors	10	6.56e-01	-0.081300	7.51e-01
HDACs deacetylate histones	38	3.86e-01	-0.081300	5.15e-01
Formation of Fibrin Clot (Clotting Cascade)	21	5.20e-01	-0.081100	6.37e-01
Cellular response to heat stress	96	1.77e-01	-0.079900	2.80e-01
HIV Life Cycle	145	9.77e-02	0.079700	1.73e-01
STAT3 nuclear events downstream of ALK signaling	10	6.64e-01	0.079200	7.58e-01
Cargo concentration in the ER	30	4.58e-01	0.078300	5.84e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	6.40e-01	0.078000	7.37e-01
Interactions of Vpr with host cellular proteins	37	4.14e-01	-0.077600	5.43e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	4.48e-01	-0.077500	5.75e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	4.48e-01	-0.077500	5.75e-01
PIP3 activates AKT signaling	246	3.73e-02	-0.077100	8.04e-02
Transcriptional Regulation by TP53	348	1.36e-02	0.077100	3.50e-02
Pexophagy	11	6.59e-01	-0.076800	7.53e-01
Signaling by Hedgehog	130	1.32e-01	0.076500	2.21e-01
Transcriptional Regulation by VENTX	39	4.12e-01	0.075900	5.41e-01
Regulation of TP53 Activity through Methylation	19	5.67e-01	0.075800	6.78e-01
Lysosome Vesicle Biogenesis	33	4.51e-01	0.075800	5.77e-01
Nuclear Pore Complex (NPC) Disassembly	36	4.32e-01	-0.075700	5.59e-01
Formation of RNA Pol II elongation complex	57	3.25e-01	0.075400	4.55e-01
RNA Polymerase II Transcription Elongation	57	3.25e-01	0.075400	4.55e-01
Interferon alpha/beta signaling	56	3.32e-01	-0.074900	4.64e-01
Macroautophagy	113	1.71e-01	0.074600	2.73e-01
Signalling to RAS	20	5.65e-01	0.074300	6.76e-01
Spry regulation of FGF signaling	16	6.07e-01	-0.074200	7.16e-01
HSF1 activation	26	5.14e-01	0.073900	6.32e-01
Glycogen breakdown (glycogenolysis)	15	6.20e-01	0.073900	7.23e-01
Late Phase of HIV Life Cycle	132	1.43e-01	0.073800	2.36e-01
RHO GTPase Effectors	241	5.02e-02	-0.073300	1.01e-01
MTOR signalling	41	4.20e-01	-0.072800	5.49e-01
Metabolism of non-coding RNA	53	3.60e-01	0.072700	4.91e-01
snRNP Assembly	53	3.60e-01	0.072700	4.91e-01
SLC transporter disorders	72	2.86e-01	-0.072700	4.10e-01
IKK complex recruitment mediated by RIP1	23	5.46e-01	0.072700	6.61e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	4.45e-01	-0.072600	5.72e-01
Signaling by FGFR3	36	4.54e-01	-0.072100	5.80e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	32	4.81e-01	0.072100	6.06e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	52	3.69e-01	-0.072000	4.98e-01
Interleukin-4 and Interleukin-13 signaling	91	2.37e-01	0.071800	3.51e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	4.70e-01	0.071500	5.96e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	27	5.23e-01	-0.071000	6.39e-01
Lewis blood group biosynthesis	11	6.84e-01	-0.070900	7.74e-01
Blood group systems biosynthesis	15	6.35e-01	-0.070800	7.33e-01
Vesicle-mediated transport	619	2.72e-03	-0.070700	9.09e-03
Unblocking of NMDA receptors, glutamate binding and activation	15	6.35e-01	-0.070700	7.33e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	5.18e-01	0.070600	6.35e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	12	6.74e-01	0.070200	7.68e-01
Generation of second messenger molecules	33	4.85e-01	0.070200	6.11e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	6.18e-01	0.069900	7.22e-01
Postmitotic nuclear pore complex (NPC) reformation	27	5.30e-01	-0.069900	6.45e-01
Metabolism of water-soluble vitamins and cofactors	109	2.08e-01	0.069900	3.18e-01
Acyl chain remodelling of PC	19	5.98e-01	-0.069800	7.07e-01
Metabolism of vitamins and cofactors	160	1.28e-01	0.069700	2.16e-01
Extracellular matrix organization	254	5.63e-02	0.069600	1.10e-01
Resolution of Sister Chromatid Cohesion	103	2.23e-01	0.069600	3.36e-01
Regulation of PTEN gene transcription	59	3.57e-01	-0.069300	4.89e-01
Chondroitin sulfate biosynthesis	17	6.21e-01	0.069200	7.23e-01
Metabolism of fat-soluble vitamins	33	4.92e-01	-0.069200	6.16e-01
RHO GTPases Activate NADPH Oxidases	21	5.84e-01	-0.069100	6.95e-01
Nuclear Envelope (NE) Reassembly	70	3.19e-01	0.068900	4.49e-01
Attenuation phase	23	5.71e-01	-0.068300	6.82e-01
Interferon Signaling	177	1.19e-01	-0.068100	2.03e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	16	6.38e-01	-0.067900	7.36e-01
RMTs methylate histone arginines	34	4.96e-01	-0.067500	6.20e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	15	6.54e-01	-0.066800	7.49e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	13	6.77e-01	-0.066700	7.70e-01
HATs acetylate histones	84	2.91e-01	-0.066700	4.15e-01
SARS-CoV-2 Infection	68	3.42e-01	0.066600	4.76e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	6.37e-01	0.066100	7.35e-01
Nuclear import of Rev protein	34	5.05e-01	-0.066100	6.26e-01
Gap junction trafficking and regulation	20	6.11e-01	-0.065800	7.17e-01
MyD88 deficiency (TLR2/4)	14	6.74e-01	-0.064900	7.68e-01
MAPK family signaling cascades	284	6.12e-02	-0.064600	1.18e-01
GPCR ligand binding	236	8.97e-02	-0.064200	1.60e-01
Signaling by FGFR2	64	3.76e-01	0.064000	5.04e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	5.14e-01	0.063800	6.32e-01
Other interleukin signaling	19	6.32e-01	-0.063400	7.33e-01
Acyl chain remodelling of PI	10	7.29e-01	-0.063200	8.12e-01
Infectious disease	732	3.71e-03	0.063200	1.16e-02
Developmental Biology	769	3.21e-03	-0.062600	1.04e-02
Trafficking and processing of endosomal TLR	13	6.97e-01	0.062500	7.83e-01
Regulation of IFNG signaling	13	6.98e-01	-0.062200	7.84e-01
Glutamate Neurotransmitter Release Cycle	22	6.17e-01	-0.061700	7.22e-01
Retinoid metabolism and transport	30	5.59e-01	-0.061600	6.71e-01
G2/M DNA damage checkpoint	62	4.05e-01	0.061100	5.35e-01
Oncogene Induced Senescence	33	5.46e-01	-0.060700	6.61e-01
Autophagy	128	2.37e-01	0.060600	3.51e-01
Post-translational protein phosphorylation	79	3.52e-01	0.060500	4.86e-01
Lysosphingolipid and LPA receptors	10	7.42e-01	-0.060100	8.18e-01
trans-Golgi Network Vesicle Budding	70	3.87e-01	-0.059800	5.16e-01
HDR through Single Strand Annealing (SSA)	37	5.30e-01	0.059700	6.45e-01
HCMV Late Events	61	4.21e-01	-0.059600	5.50e-01
ISG15 antiviral mechanism	72	3.90e-01	-0.058600	5.19e-01
Formation of apoptosome	11	7.38e-01	0.058300	8.15e-01
Regulation of the apoptosome activity	11	7.38e-01	0.058300	8.15e-01
TP53 Regulates Metabolic Genes	86	3.54e-01	0.057900	4.87e-01
Negative regulation of FGFR4 signaling	25	6.17e-01	-0.057800	7.22e-01
Telomere C-strand synthesis initiation	13	7.19e-01	-0.057700	8.02e-01
Degradation of the extracellular matrix	88	3.52e-01	0.057400	4.86e-01
Neutrophil degranulation	428	4.21e-02	0.057400	8.93e-02
Assembly Of The HIV Virion	16	6.92e-01	0.057200	7.80e-01
Signaling by CSF3 (G-CSF)	29	5.94e-01	-0.057200	7.03e-01
FCERI mediated Ca+2 mobilization	44	5.13e-01	0.057100	6.32e-01
Regulation of IFNA signaling	12	7.33e-01	0.056800	8.13e-01
ER Quality Control Compartment (ERQC)	21	6.52e-01	-0.056800	7.48e-01
Mitochondrial biogenesis	91	3.54e-01	0.056200	4.87e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	24	6.34e-01	-0.056100	7.33e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	24	6.34e-01	-0.056100	7.33e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	24	6.34e-01	-0.056100	7.33e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	24	6.34e-01	-0.056100	7.33e-01
Diseases of DNA Double-Strand Break Repair	24	6.34e-01	-0.056100	7.33e-01
Processing of Intronless Pre-mRNAs	19	6.79e-01	0.054900	7.70e-01
Generic Transcription Pathway	1096	2.59e-03	-0.054100	8.78e-03
MyD88-independent TLR4 cascade	96	3.66e-01	-0.053400	4.96e-01
TRIF(TICAM1)-mediated TLR4 signaling	96	3.66e-01	-0.053400	4.96e-01
Visual phototransduction	64	4.63e-01	-0.053000	5.90e-01
WNT ligand biogenesis and trafficking	20	6.83e-01	0.052700	7.74e-01
TP53 Regulates Transcription of Cell Cycle Genes	44	5.46e-01	0.052600	6.61e-01
Leading Strand Synthesis	14	7.36e-01	0.052100	8.14e-01
Polymerase switching	14	7.36e-01	0.052100	8.14e-01
NOD1/2 Signaling Pathway	32	6.11e-01	-0.052000	7.17e-01
Interactions of Rev with host cellular proteins	37	5.84e-01	-0.052000	6.95e-01
Mitotic Prophase	91	3.93e-01	-0.051900	5.22e-01
Signaling by Insulin receptor	66	4.67e-01	-0.051800	5.94e-01
Rev-mediated nuclear export of HIV RNA	35	5.98e-01	-0.051500	7.07e-01
HIV elongation arrest and recovery	32	6.14e-01	0.051500	7.20e-01
Pausing and recovery of HIV elongation	32	6.14e-01	0.051500	7.20e-01
CS/DS degradation	12	7.58e-01	0.051400	8.28e-01
Ub-specific processing proteases	161	2.65e-01	0.050900	3.84e-01
Retrograde transport at the Trans-Golgi-Network	49	5.41e-01	-0.050500	6.56e-01
Membrane binding and targetting of GAG proteins	14	7.46e-01	0.050100	8.19e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	7.46e-01	0.050100	8.19e-01
Regulation of HSF1-mediated heat shock response	79	4.46e-01	-0.049700	5.72e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	24	6.76e-01	-0.049300	7.69e-01
SUMOylation of RNA binding proteins	47	5.59e-01	-0.049300	6.71e-01
Protein folding	88	4.27e-01	0.049000	5.56e-01
RNA Polymerase III Transcription Termination	23	6.89e-01	-0.048200	7.78e-01
Alpha-protein kinase 1 signaling pathway	11	7.82e-01	-0.048100	8.47e-01
Toll Like Receptor 3 (TLR3) Cascade	92	4.28e-01	-0.047800	5.56e-01
RHOBTB2 GTPase cycle	23	6.93e-01	0.047600	7.81e-01
Peptide hormone metabolism	62	5.18e-01	0.047500	6.35e-01
Deadenylation-dependent mRNA decay	53	5.50e-01	0.047500	6.63e-01
SHC-mediated cascade:FGFR3	14	7.60e-01	0.047100	8.30e-01
Nonhomologous End-Joining (NHEJ)	37	6.21e-01	-0.047000	7.23e-01
Defects in vitamin and cofactor metabolism	20	7.16e-01	-0.046900	8.00e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	25	6.85e-01	0.046800	7.75e-01
E3 ubiquitin ligases ubiquitinate target proteins	47	5.85e-01	0.046100	6.95e-01
Organelle biogenesis and maintenance	270	1.94e-01	0.046000	3.01e-01
Nuclear events stimulated by ALK signaling in cancer	19	7.30e-01	0.045700	8.12e-01
Gene expression (Transcription)	1345	5.67e-03	-0.045200	1.66e-02
COPI-independent Golgi-to-ER retrograde traffic	33	6.54e-01	-0.045100	7.49e-01
Phosphorylation of CD3 and TCR zeta chains	22	7.15e-01	0.045000	8.00e-01
Centrosome maturation	81	4.88e-01	0.044600	6.13e-01
Recruitment of mitotic centrosome proteins and complexes	81	4.88e-01	0.044600	6.13e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	44	6.09e-01	-0.044500	7.17e-01
Polymerase switching on the C-strand of the telomere	26	6.95e-01	0.044500	7.82e-01
Negative regulation of MAPK pathway	42	6.21e-01	0.044100	7.23e-01
Metabolism of lipids	624	6.12e-02	-0.044000	1.18e-01
Signaling by FGFR	75	5.10e-01	0.044000	6.30e-01
Transport to the Golgi and subsequent modification	156	3.47e-01	0.043700	4.81e-01
Kinesins	37	6.46e-01	0.043700	7.42e-01
Regulation of TP53 Activity through Phosphorylation	89	4.88e-01	0.042500	6.13e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	7.15e-01	-0.042200	8.00e-01
Amino acid transport across the plasma membrane	22	7.36e-01	0.041500	8.14e-01
Activation of HOX genes during differentiation	69	5.51e-01	-0.041500	6.63e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	69	5.51e-01	-0.041500	6.63e-01
SUMOylation of immune response proteins	11	8.14e-01	0.041000	8.72e-01
Class A/1 (Rhodopsin-like receptors)	171	3.56e-01	-0.040900	4.88e-01
Transport of the SLBP independent Mature mRNA	35	6.79e-01	-0.040400	7.70e-01
Cilium Assembly	179	3.53e-01	0.040300	4.86e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	7.76e-01	0.039800	8.42e-01
Cytosolic sensors of pathogen-associated DNA	63	5.87e-01	0.039600	6.97e-01
Cell recruitment (pro-inflammatory response)	23	7.43e-01	-0.039500	8.18e-01
Purinergic signaling in leishmaniasis infection	23	7.43e-01	-0.039500	8.18e-01
Carboxyterminal post-translational modifications of tubulin	29	7.17e-01	0.039000	8.00e-01
RNA Polymerase II Transcription	1214	2.48e-02	-0.038400	5.76e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	14	8.04e-01	0.038300	8.65e-01
Initiation of Nuclear Envelope (NE) Reformation	19	7.75e-01	0.037900	8.42e-01
Class I MHC mediated antigen processing & presentation	354	2.26e-01	0.037500	3.39e-01
SARS-CoV-1 Infection	47	6.58e-01	0.037400	7.52e-01
TRP channels	19	7.79e-01	0.037200	8.44e-01
Defects in cobalamin (B12) metabolism	12	8.24e-01	-0.037200	8.81e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	89	5.49e-01	0.036700	6.63e-01
TNFR1-induced NFkappaB signaling pathway	26	7.47e-01	-0.036600	8.19e-01
Integrin cell surface interactions	58	6.30e-01	0.036600	7.32e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	7.89e-01	-0.036400	8.53e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	30	7.32e-01	-0.036200	8.12e-01
Calnexin/calreticulin cycle	26	7.56e-01	-0.035200	8.27e-01
Synthesis of bile acids and bile salts	26	7.62e-01	0.034400	8.31e-01
O-linked glycosylation of mucins	46	6.88e-01	0.034300	7.77e-01
Antigen processing: Ubiquitination & Proteasome degradation	290	3.17e-01	0.034200	4.46e-01
Protein ubiquitination	67	6.29e-01	0.034100	7.32e-01
p38MAPK events	13	8.32e-01	0.033900	8.87e-01
Amyloid fiber formation	43	7.03e-01	0.033600	7.89e-01
Mitotic Prometaphase	184	4.33e-01	0.033500	5.60e-01
Signaling by Retinoic Acid	36	7.32e-01	0.033000	8.12e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	11	8.50e-01	-0.032900	8.97e-01
Diseases of hemostasis	11	8.50e-01	-0.032900	8.97e-01
Biotin transport and metabolism	11	8.51e-01	0.032800	8.97e-01
MHC class II antigen presentation	100	5.81e-01	0.031900	6.93e-01
Arachidonic acid metabolism	39	7.31e-01	0.031900	8.12e-01
Regulation of TP53 Activity	153	5.05e-01	-0.031200	6.26e-01
Diseases of DNA repair	33	7.59e-01	0.030800	8.29e-01
Regulation of TP53 Degradation	35	7.54e-01	0.030600	8.26e-01
Other semaphorin interactions	19	8.18e-01	-0.030500	8.76e-01
Inactivation of CSF3 (G-CSF) signaling	24	7.97e-01	0.030400	8.58e-01
SLC-mediated transmembrane transport	167	4.99e-01	0.030300	6.24e-01
SHC-mediated cascade:FGFR2	16	8.36e-01	0.029900	8.88e-01
Signaling by Interleukins	385	3.22e-01	0.029400	4.53e-01
Diseases associated with O-glycosylation of proteins	56	7.06e-01	-0.029200	7.92e-01
DNA Double Strand Break Response	45	7.36e-01	-0.029100	8.14e-01
Translation of Structural Proteins	29	7.91e-01	-0.028400	8.53e-01
NGF-stimulated transcription	35	7.72e-01	-0.028300	8.40e-01
Bile acid and bile salt metabolism	30	7.91e-01	0.028000	8.53e-01
Transport of small molecules	555	2.61e-01	0.028000	3.79e-01
FCGR3A-mediated IL10 synthesis	57	7.16e-01	-0.027900	8.00e-01
Negative regulation of FGFR2 signaling	27	8.08e-01	-0.027000	8.68e-01
Oxidative Stress Induced Senescence	72	6.93e-01	0.026900	7.81e-01
Cellular Senescence	137	5.88e-01	0.026800	6.98e-01
TCF dependent signaling in response to WNT	164	5.56e-01	-0.026700	6.68e-01
Recruitment of NuMA to mitotic centrosomes	80	6.82e-01	0.026500	7.73e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	8.30e-01	-0.026400	8.85e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	8.61e-01	-0.026200	9.04e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	8.61e-01	-0.026200	9.04e-01
Regulation of TP53 Expression and Degradation	36	7.86e-01	0.026100	8.50e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	8.61e-01	-0.026100	9.04e-01
Acyl chain remodelling of PS	14	8.67e-01	0.025800	9.06e-01
Muscle contraction	150	5.91e-01	-0.025400	7.01e-01
STING mediated induction of host immune responses	15	8.65e-01	0.025400	9.04e-01
DNA Damage/Telomere Stress Induced Senescence	37	7.90e-01	-0.025300	8.53e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	8.91e-01	-0.025000	9.27e-01
SUMOylation of DNA methylation proteins	16	8.64e-01	-0.024800	9.04e-01
RHOBTB3 ATPase cycle	10	8.94e-01	0.024200	9.28e-01
Smooth Muscle Contraction	33	8.10e-01	-0.024200	8.69e-01
Condensation of Prometaphase Chromosomes	11	8.90e-01	0.024100	9.27e-01
Hyaluronan metabolism	16	8.68e-01	0.024000	9.06e-01
Ion channel transport	137	6.29e-01	-0.023900	7.32e-01
RIP-mediated NFkB activation via ZBP1	17	8.65e-01	-0.023800	9.04e-01
O-glycosylation of TSR domain-containing proteins	36	8.06e-01	0.023700	8.66e-01
mTORC1-mediated signalling	24	8.41e-01	0.023600	8.91e-01
SUMOylation of DNA replication proteins	46	7.83e-01	-0.023500	8.47e-01
Downregulation of TGF-beta receptor signaling	26	8.38e-01	-0.023200	8.89e-01
Meiosis	55	7.68e-01	-0.023000	8.37e-01
Innate Immune System	896	2.46e-01	0.022900	3.59e-01
Chaperonin-mediated protein folding	82	7.22e-01	0.022800	8.05e-01
Sialic acid metabolism	29	8.34e-01	0.022500	8.88e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	70	7.45e-01	-0.022400	8.19e-01
RNA polymerase II transcribes snRNA genes	71	7.47e-01	0.022200	8.19e-01
Negative regulation of FGFR3 signaling	25	8.50e-01	-0.021900	8.97e-01
Branched-chain amino acid catabolism	21	8.63e-01	-0.021800	9.04e-01
tRNA processing	134	6.71e-01	0.021300	7.65e-01
RAS processing	19	8.73e-01	0.021200	9.10e-01
Signaling by FGFR2 in disease	36	8.26e-01	0.021200	8.82e-01
Loss of Nlp from mitotic centrosomes	69	7.75e-01	-0.019900	8.42e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	7.75e-01	-0.019900	8.42e-01
Interleukin-2 signaling	11	9.09e-01	-0.019800	9.39e-01
Killing mechanisms	10	9.14e-01	-0.019800	9.40e-01
WNT5:FZD7-mediated leishmania damping	10	9.14e-01	-0.019800	9.40e-01
Glycosphingolipid metabolism	38	8.34e-01	-0.019600	8.88e-01
Energy dependent regulation of mTOR by LKB1-AMPK	29	8.59e-01	-0.019000	9.04e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	8.96e-01	-0.018900	9.29e-01
Axon guidance	487	4.80e-01	0.018700	6.06e-01
MAPK1/MAPK3 signaling	248	6.12e-01	-0.018700	7.19e-01
RHO GTPases Activate Formins	117	7.29e-01	0.018600	8.12e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	19	8.92e-01	-0.018000	9.27e-01
Neurodegenerative Diseases	19	8.92e-01	-0.018000	9.27e-01
ZBP1(DAI) mediated induction of type I IFNs	20	8.90e-01	0.017900	9.27e-01
NF-kB is activated and signals survival	13	9.13e-01	0.017500	9.40e-01
RAF/MAP kinase cascade	242	6.43e-01	-0.017300	7.40e-01
ECM proteoglycans	48	8.36e-01	-0.017200	8.88e-01
Deubiquitination	234	6.52e-01	-0.017200	7.48e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	46	8.41e-01	0.017100	8.91e-01
SHC-mediated cascade:FGFR4	14	9.12e-01	-0.017000	9.40e-01
Intrinsic Pathway of Fibrin Clot Formation	14	9.13e-01	-0.016800	9.40e-01
Cell surface interactions at the vascular wall	124	7.47e-01	-0.016800	8.19e-01
Transport of the SLBP Dependant Mature mRNA	36	8.63e-01	-0.016600	9.04e-01
Gap junction trafficking	18	9.05e-01	-0.016200	9.36e-01
Phase 4 - resting membrane potential	12	9.23e-01	0.016100	9.44e-01
Positive epigenetic regulation of rRNA expression	55	8.37e-01	-0.016100	8.88e-01
TNF signaling	44	8.54e-01	0.016100	9.00e-01
Anchoring of the basal body to the plasma membrane	97	7.89e-01	0.015700	8.53e-01
Beta-catenin independent WNT signaling	136	7.55e-01	0.015500	8.26e-01
The phototransduction cascade	22	9.03e-01	-0.015100	9.34e-01
RA biosynthesis pathway	16	9.18e-01	-0.014900	9.42e-01
Cargo trafficking to the periciliary membrane	45	8.64e-01	0.014800	9.04e-01
Selective autophagy	60	8.49e-01	-0.014300	8.97e-01
p75NTR signals via NF-kB	16	9.22e-01	0.014100	9.44e-01
Post-translational protein modification	1219	4.28e-01	0.013600	5.56e-01
SARS-CoV Infections	148	7.76e-01	-0.013500	8.42e-01
Regulation of PLK1 Activity at G2/M Transition	87	8.30e-01	0.013400	8.85e-01
Epigenetic regulation of gene expression	96	8.25e-01	-0.013100	8.81e-01
Class I peroxisomal membrane protein import	20	9.20e-01	-0.013000	9.44e-01
Glycosaminoglycan metabolism	111	8.22e-01	0.012400	8.80e-01
Synthesis of PC	26	9.13e-01	0.012400	9.40e-01
IRAK4 deficiency (TLR2/4)	15	9.35e-01	-0.012100	9.55e-01
Defective Intrinsic Pathway for Apoptosis	22	9.22e-01	0.012000	9.44e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	9.16e-01	0.011900	9.41e-01
Phase 2 - plateau phase	10	9.49e-01	-0.011700	9.66e-01
Immune System	1686	4.33e-01	-0.011600	5.60e-01
Glycerophospholipid biosynthesis	107	8.40e-01	-0.011300	8.90e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	10	9.51e-01	0.011200	9.67e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	9.01e-01	-0.011100	9.33e-01
B-WICH complex positively regulates rRNA expression	40	9.07e-01	-0.010700	9.37e-01
Signaling by NOTCH	180	8.07e-01	0.010600	8.67e-01
Interleukin-6 family signaling	22	9.38e-01	0.009610	9.56e-01
Stimuli-sensing channels	76	8.93e-01	-0.008890	9.27e-01
Cytokine Signaling in Immune system	605	7.11e-01	-0.008840	7.97e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	9.60e-01	0.008450	9.74e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	9.26e-01	0.008180	9.46e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	177	8.59e-01	0.007750	9.04e-01
Biosynthesis of specialized proresolving mediators (SPMs)	15	9.60e-01	0.007440	9.74e-01
Transcriptional regulation by RUNX1	172	8.68e-01	0.007320	9.06e-01
Disease	1405	6.78e-01	-0.006640	7.70e-01
Viral Messenger RNA Synthesis	44	9.41e-01	0.006460	9.59e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	9.67e-01	0.006190	9.78e-01
Acyl chain remodelling of PE	19	9.63e-01	0.006160	9.76e-01
Elastic fibre formation	38	9.51e-01	0.005760	9.67e-01
Intrinsic Pathway for Apoptosis	53	9.42e-01	0.005760	9.59e-01
Termination of O-glycan biosynthesis	14	9.71e-01	0.005660	9.81e-01
Inactivation, recovery and regulation of the phototransduction cascade	21	9.64e-01	0.005620	9.77e-01
Metabolism of steroids	121	9.22e-01	0.005190	9.44e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	9.77e-01	-0.004260	9.83e-01
Response to elevated platelet cytosolic Ca2+	113	9.53e-01	0.003180	9.68e-01
Transcriptional Regulation by E2F6	34	9.76e-01	0.002930	9.83e-01
RNA Polymerase III Abortive And Retractive Initiation	41	9.74e-01	-0.002920	9.82e-01
RNA Polymerase III Transcription	41	9.74e-01	-0.002920	9.82e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	67	9.70e-01	-0.002630	9.81e-01
Adaptive Immune System	688	9.15e-01	0.002400	9.40e-01
Transport of bile salts and organic acids, metal ions and amine compounds	54	9.76e-01	-0.002380	9.83e-01
Gene Silencing by RNA	81	9.71e-01	-0.002330	9.81e-01
Nervous system development	508	9.31e-01	0.002250	9.51e-01
Reproduction	64	9.84e-01	-0.001450	9.89e-01
Biosynthesis of DHA-derived SPMs	13	9.94e-01	-0.001290	9.96e-01
RNA Polymerase I Promoter Opening	12	9.94e-01	-0.001230	9.96e-01
O-linked glycosylation	91	9.88e-01	0.000930	9.93e-01
Negative regulators of DDX58/IFIH1 signaling	35	9.93e-01	-0.000855	9.96e-01
Platelet degranulation	109	9.89e-01	-0.000790	9.93e-01
Defective B3GALTL causes PpS	35	9.97e-01	0.000342	9.98e-01
AURKA Activation by TPX2	72	9.96e-01	0.000321	9.98e-01
Transcriptional regulation by small RNAs	56	9.98e-01	0.000206	9.98e-01

---

Detailed Gene set reports

Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin

	203
set	Cohesin Loading onto Chromatin
setSize	10
pANOVA	5.84e-06
s.dist	-0.827
p.adjustANOVA	4.31e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAG2	-9118
SMC1A	-8905
STAG1	-8800
NIPBL	-8771
WAPL	-8597
PDS5B	-8339
PDS5A	-7791
RAD21	-7480
SMC3	-6913
MAU2	-763

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAG2	-9118
SMC1A	-8905
STAG1	-8800
NIPBL	-8771
WAPL	-8597
PDS5B	-8339
PDS5A	-7791
RAD21	-7480
SMC3	-6913
MAU2	-763

---

RORA activates gene expression

RORA activates gene expression

	973
set	RORA activates gene expression
setSize	18
pANOVA	5.97e-08
s.dist	-0.738
p.adjustANOVA	5.6e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCOA2	-9164
MED1	-9157
CREBBP	-9155
EP300	-9090
NCOA1	-9056
TBL1X	-9006
PPARA	-8979
RXRA	-8850
NCOA6	-8716
HELZ2	-8193
TBL1XR1	-8113
CHD9	-7568
CPT1A	-6739
CARM1	-6136
SREBF1	-5367
RORA	-3692
TGS1	-2733
SMARCD3	9058

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCOA2	-9164
MED1	-9157
CREBBP	-9155
EP300	-9090
NCOA1	-9056
TBL1X	-9006
PPARA	-8979
RXRA	-8850
NCOA6	-8716
HELZ2	-8193
TBL1XR1	-8113
CHD9	-7568
CPT1A	-6739
CARM1	-6136
SREBF1	-5367
RORA	-3692
TGS1	-2733
SMARCD3	9058

---

Peptide chain elongation

Peptide chain elongation

	834
set	Peptide chain elongation
setSize	87
pANOVA	3.47e-31
s.dist	0.719
p.adjustANOVA	6.26e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
EEF1A1	7713
RPS27A	7616
RPL24	7590
RPL22	7554
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
RPL36AL	1593
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EEF2	-4673

---

Viral mRNA Translation

Viral mRNA Translation

	1396
set	Viral mRNA Translation
setSize	87
pANOVA	8.76e-31
s.dist	0.714
p.adjustANOVA	1.41e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
GRSF1	4912
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
RPL36AL	1593
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
DNAJC3	-5856

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	368
set	Eukaryotic Translation Elongation
setSize	92
pANOVA	2.3e-32
s.dist	0.713
p.adjustANOVA	6.64e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
EEF1A2	9197
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
EEF1A2	9197
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
EEF1A1	7713
RPS27A	7616
RPL24	7590
RPL22	7554
EEF1D	7538
EEF1B2	7505
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
EEF1G	5962
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
RPL36AL	1593
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EEF1A1P5	-897
EEF2	-4673

---

Selenocysteine synthesis

Selenocysteine synthesis

	1118
set	Selenocysteine synthesis
setSize	91
pANOVA	2.94e-31
s.dist	0.704
p.adjustANOVA	6.07e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
RPL35A	7451
RPL27	7431
SARS1	7406
SEPHS2	7402
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
SECISBP2	6750
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
PSTK	2044
RPL36AL	1593
SEPSECS	615
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EEFSEC	-6441

---

Activation of RAC1

Activation of RAC1

	48
set	Activation of RAC1
setSize	11
pANOVA	5.66e-05
s.dist	-0.701
p.adjustANOVA	0.000355

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PAK2	-8921
SOS2	-8715
SOS1	-8625
PAK4	-7673
ROBO1	-7611
RAC1	-6585
SLIT2	-6303
NCK2	-5838
PAK1	-4069
PAK3	-3889
NCK1	-1766

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PAK2	-8921
SOS2	-8715
SOS1	-8625
PAK4	-7673
ROBO1	-7611
RAC1	-6585
SLIT2	-6303
NCK2	-5838
PAK1	-4069
PAK3	-3889
NCK1	-1766

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

	365
set	Establishment of Sister Chromatid Cohesion
setSize	11
pANOVA	6.09e-05
s.dist	-0.698
p.adjustANOVA	0.000377

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAG2	-9118
SMC1A	-8905
STAG1	-8800
WAPL	-8597
PDS5B	-8339
PDS5A	-7791
RAD21	-7480
SMC3	-6913
ESCO1	-6306
ESCO2	-2126
CDCA5	4696

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAG2	-9118
SMC1A	-8905
STAG1	-8800
WAPL	-8597
PDS5B	-8339
PDS5A	-7791
RAD21	-7480
SMC3	-6913
ESCO1	-6306
ESCO2	-2126
CDCA5	4696

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	370
set	Eukaryotic Translation Termination
setSize	91
pANOVA	1.14e-30
s.dist	0.697
p.adjustANOVA	1.64e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
TRMT112	8446
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
APEH	3779
RPS11	3631
RPL38	3471
N6AMT1	2188
RPL36AL	1593
ETF1	1135
RPS26	365
RPLP2	348
RPL36	-106
GSPT2	-543
RPL9	-732
GSPT1	-3174

---

Regulation of signaling by CBL

Regulation of signaling by CBL

	1047
set	Regulation of signaling by CBL
setSize	18
pANOVA	4.22e-07
s.dist	-0.689
p.adjustANOVA	3.57e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAPGEF1	-8987
CBL	-8616
PIK3R1	-8472
PIK3CA	-8387
CRKL	-8380
FYN	-7914
PIK3R2	-7596
YES1	-7307
PIK3CB	-6590
SYK	-6513
CRK	-6198
BLNK	-5737
PIK3CD	-5104
LYN	-4720
GRB2	-4675
PIK3R3	-4145
HCK	-2221
VAV1	-818

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAPGEF1	-8987
CBL	-8616
PIK3R1	-8472
PIK3CA	-8387
CRKL	-8380
FYN	-7914
PIK3R2	-7596
YES1	-7307
PIK3CB	-6590
SYK	-6513
CRK	-6198
BLNK	-5737
PIK3CD	-5104
LYN	-4720
GRB2	-4675
PIK3R3	-4145
HCK	-2221
VAV1	-818

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1096
set	SRP-dependent cotranslational protein targeting to membrane
setSize	110
pANOVA	1.2e-34
s.dist	0.677
p.adjustANOVA	4.55e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
SEC61G	9571
RPS13	9507
RPS15A	9506
RPL34	9423
SEC61B	9403
SSR4	9342
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
SEC11A	9243
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
SEC61G	9571
RPS13	9507
RPS15A	9506
RPL34	9423
SEC61B	9403
SSR4	9342
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
SEC11A	9243
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
SSR2	8461
RPL18	8453
RPL6	8419
SRP54	8282
RPS21	8271
RPL7A	8262
RPN2	8220
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
SEC61A2	7664
RPS27A	7616
SRPRB	7614
RPL24	7590
RPL22	7554
SRP19	7462
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
DDOST	7104
SRP9	7024
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
RPL8	6487
RPL27A	6369
RPL12	6341
SRP14	6293
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
SRP68	5690
SRPRA	5667
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
SPCS2	5395
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
SEC11C	4555
SEC61A1	4489
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
RPN1	3272
RPL36AL	1593
SSR3	499
RPS26	365
RPLP2	348
RPL36	-106
SPCS1	-534
RPL9	-732
SSR1	-2252
TRAM1	-4118
SPCS3	-5358
SRP72	-5780

---

NOTCH2 intracellular domain regulates transcription

NOTCH2 intracellular domain regulates transcription

	727
set	NOTCH2 intracellular domain regulates transcription
setSize	10
pANOVA	0.000229
s.dist	-0.673
p.adjustANOVA	0.00117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EP300	-9090
CREB1	-8788
MAML2	-8717
RBPJ	-8620
NOTCH2	-8595
MAML1	-8510
MAML3	-8481
FCER2	-5302
HES1	-1543
MAMLD1	6663

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EP300	-9090
CREB1	-8788
MAML2	-8717
RBPJ	-8620
NOTCH2	-8595
MAML1	-8510
MAML3	-8481
FCER2	-5302
HES1	-1543
MAMLD1	6663

---

tRNA processing in the mitochondrion

tRNA processing in the mitochondrion

	1443
set	tRNA processing in the mitochondrion
setSize	30
pANOVA	3.05e-10
s.dist	-0.664
p.adjustANOVA	3.86e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-TY	-9159
MT-TE	-9156
MT-ATP8	-9153
MT-TS1	-9151
MT-TC	-9107
MT-TA	-9058
MT-TN	-9001
MT-ND5	-8980
MT-ND6	-8948
MT-TL1	-8924
MT-ND2	-8890
MT-TL2	-8831
MT-ND4L	-8818
MT-ND4	-8773
MT-ND1	-8697
MT-CYB	-8561
MT-ATP6	-8482
MT-ND3	-8051
MT-TV	-7872
MT-TP	-7631

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-TY	-9159
MT-TE	-9156
MT-ATP8	-9153
MT-TS1	-9151
MT-TC	-9107
MT-TA	-9058
MT-TN	-9001
MT-ND5	-8980
MT-ND6	-8948
MT-TL1	-8924
MT-ND2	-8890
MT-TL2	-8831
MT-ND4L	-8818
MT-ND4	-8773
MT-ND1	-8697
MT-CYB	-8561
MT-ATP6	-8482
MT-ND3	-8051
MT-TV	-7872
MT-TP	-7631
MT-CO1	-7286
MT-CO2	-7283
MT-CO3	-7280
MT-RNR2	-4674
MT-RNR1	-2520
ELAC2	2664
TRMT10C	3961
PRORP	4131
TRNT1	5100
HSD17B10	8159

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	411
set	Formation of a pool of free 40S subunits
setSize	99
pANOVA	7.91e-30
s.dist	0.659
p.adjustANOVA	1.04e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
EIF3K	7542
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
EIF3I	7000
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
EIF3M	6690
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
EIF3H	5898
EIF3J	5593
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
EIF3E	5377
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
EIF3L	3206
EIF3D	2366
RPL36AL	1593
EIF3B	1164
EIF3G	767
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EIF3F	-1567
EIF3C	-3076
EIF1AX	-5520
EIF3A	-5646

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1062
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	99
pANOVA	9.58e-29
s.dist	0.646
p.adjustANOVA	1.06e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
ASNS	9132
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
ASNS	9132
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786
RPS3	8783
ATF4	8766
RPL29	8755
RPSA	8710
DDIT3	8698
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
ATF3	8307
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
TRIB3	6706
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
CEBPG	3377
EIF2S1	1682
RPL36AL	1593
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
CEBPB	-2263
IMPACT	-2680
GCN1	-7474
ATF2	-8196
EIF2AK4	-8377
EIF2S3	-8439

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	767
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	93
pANOVA	4.67e-27
s.dist	0.646
p.adjustANOVA	3.49e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
RPL35A	7451
NCBP2	7436
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
RPL36AL	1593
ETF1	1135
RPS26	365
RPLP2	348
RPL36	-106
GSPT2	-543
RPL9	-732
GSPT1	-3174
NCBP1	-3260
EIF4G1	-5703
UPF1	-6693
PABPC1	-8891

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1117
set	Selenoamino acid metabolism
setSize	113
pANOVA	2.96e-32
s.dist	0.643
p.adjustANOVA	7.12e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
PAPSS1	9300
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
NNMT	8915
RPL30	8843
RPL41	8812

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
PAPSS1	9300
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
NNMT	8915
RPL30	8843
RPL41	8812
EEF1E1	8800
RPL31	8793
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
MARS1	8665
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
DARS1	8117
RPL11	7997
FAU	7952
RPL13A	7869
PAPSS2	7816
RPL37	7790
RARS1	7775
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
IARS1	7470
RPL35A	7451
RPL27	7431
SARS1	7406
SEPHS2	7402
RPS14	7386
RPS6	7288
RPS7	7136
CBS	7121
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
AIMP1	6825
SECISBP2	6750
RPL8	6487
AIMP2	6397
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
RPS15	5904
QARS1	5901
RPL18A	5543
RPL4	5504
KARS1	5478
RPL19	5473
RPS2	5410
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
SCLY	2082
PSTK	2044
AHCY	1878
RPL36AL	1593
SEPSECS	615
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
CTH	-902
LARS1	-1463
EPRS1	-2193
GSR	-2531
TXNRD1	-2612
HNMT	-3216
INMT	-6111
EEFSEC	-6441

---

CREB1 phosphorylation through the activation of Adenylate Cyclase

CREB1 phosphorylation through the activation of Adenylate Cyclase

	142
set	CREB1 phosphorylation through the activation of Adenylate Cyclase
setSize	11
pANOVA	0.00024
s.dist	-0.639
p.adjustANOVA	0.00122

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PRKACA	-9077
PRKAR2A	-8816
CREB1	-8788
PRKACB	-8043
PRKAR1A	-7840
PRKX	-7015
PRKAR2B	-6774
ADCY1	-3387
ADCY8	-2035
PRKAR1B	-1468
CALM1	-402

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PRKACA	-9077
PRKAR2A	-8816
CREB1	-8788
PRKACB	-8043
PRKAR1A	-7840
PRKX	-7015
PRKAR2B	-6774
ADCY1	-3387
ADCY8	-2035
PRKAR1B	-1468
CALM1	-402

---

PI3K events in ERBB2 signaling

PI3K events in ERBB2 signaling

	813
set	PI3K events in ERBB2 signaling
setSize	13
pANOVA	0.000116
s.dist	-0.617
p.adjustANOVA	0.000651

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EGFR	-9149
PIK3R1	-8472
PIK3CA	-8387
ERBB3	-7973
ERBB2	-7641
ERBB4	-7547
GAB1	-7242
BTC	-4685
GRB2	-4675
HBEGF	-3740
NRG2	-1409
EREG	-1208
EGF	-405

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EGFR	-9149
PIK3R1	-8472
PIK3CA	-8387
ERBB3	-7973
ERBB2	-7641
ERBB4	-7547
GAB1	-7242
BTC	-4685
GRB2	-4675
HBEGF	-3740
NRG2	-1409
EREG	-1208
EGF	-405

---

APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of mitotic proteins

	16
set	APC/C:Cdc20 mediated degradation of mitotic proteins
setSize	73
pANOVA	7.67e-20
s.dist	0.617
p.adjustANOVA	3.17e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599
PSMD4	8501
PTTG1	8477
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
BUB3	8013
CDK1	7905
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
MAD2L1	7498
PSMA7	7461
UBE2C	7218
PSMC4	6376
BUB1B	5697
CDC20	5696
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
CCNA2	4481
NEK2	4335
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

	36
set	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
setSize	74
pANOVA	4.64e-20
s.dist	0.616
p.adjustANOVA	2.09e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599
PSMD4	8501
PTTG1	8477
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
BUB3	8013
CDK1	7905
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
MAD2L1	7498
PSMA7	7461
UBE2C	7218
PSMC4	6376
BUB1B	5697
CDC20	5696
PLK1	5577
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
CCNA2	4481
NEK2	4335
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

	1381
set	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize	50
pANOVA	4.9e-14
s.dist	0.616
p.adjustANOVA	1.11e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
CHEK2	8691
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
CHEK2	8691
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
CHEK1	5198
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC25A	996
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935

---

p53-Independent DNA Damage Response

p53-Independent DNA Damage Response

	1430
set	p53-Independent DNA Damage Response
setSize	50
pANOVA	4.9e-14
s.dist	0.616
p.adjustANOVA	1.11e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
CHEK2	8691
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
CHEK2	8691
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
CHEK1	5198
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC25A	996
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935

---

p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint

	1431
set	p53-Independent G1/S DNA damage checkpoint
setSize	50
pANOVA	4.9e-14
s.dist	0.616
p.adjustANOVA	1.11e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
CHEK2	8691
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
CHEK2	8691
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
CHEK1	5198
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC25A	996
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935

---

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

	161
set	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
setSize	70
pANOVA	8.89e-19
s.dist	0.611
p.adjustANOVA	3.13e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
BUB3	8013
CDK1	7905
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
MAD2L1	7498
PSMA7	7461
UBE2C	7218
PSMC4	6376
BUB1B	5697
CDC20	5696
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
CCNA2	4481
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

	18
set	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
setSize	71
pANOVA	6.88e-19
s.dist	0.609
p.adjustANOVA	2.48e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
BUB3	8013
CDK1	7905
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
MAD2L1	7498
PSMA7	7461
UBE2C	7218
PSMC4	6376
BUB1B	5697
CDC20	5696
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
CCNA2	4481
NEK2	4335
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

APC/C:Cdc20 mediated degradation of Securin

APC/C:Cdc20 mediated degradation of Securin

	15
set	APC/C:Cdc20 mediated degradation of Securin
setSize	66
pANOVA	1.16e-17
s.dist	0.609
p.adjustANOVA	3.51e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PTTG1	8477
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
UBE2C	7218
PSMC4	6376
CDC20	5696
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

Free fatty acids regulate insulin secretion

Free fatty acids regulate insulin secretion

	419
set	Free fatty acids regulate insulin secretion
setSize	10
pANOVA	0.000885
s.dist	-0.607
p.adjustANOVA	0.00372

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNAQ	-9068
GNA11	-8554
PLCB1	-8415
ACSL3	-7612
PLCB3	-7390
ACSL4	-7284
GNA15	-5789
CD36	-3806
GNA14	1097
PLCB2	1983

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNAQ	-9068
GNA11	-8554
PLCB1	-8415
ACSL3	-7612
PLCB3	-7390
ACSL4	-7284
GNA15	-5789
CD36	-3806
GNA14	1097
PLCB2	1983

---

APC/C:Cdc20 mediated degradation of Cyclin B

APC/C:Cdc20 mediated degradation of Cyclin B

	14
set	APC/C:Cdc20 mediated degradation of Cyclin B
setSize	24
pANOVA	3.06e-07
s.dist	0.604
p.adjustANOVA	2.65e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC5	9531
ANAPC11	9491
ANAPC7	9379
CDC16	8983
CCNB1	8630
UBB	8429
ANAPC15	8289
CDC26	8112
ANAPC2	8085
ANAPC4	8042
CDK1	7905
ANAPC10	7872
UBA52	7750
UBE2S	7726
UBE2E1	7712
RPS27A	7616
UBE2C	7218
CDC20	5696
ANAPC16	5006
UBC	3044

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC5	9531
ANAPC11	9491
ANAPC7	9379
CDC16	8983
CCNB1	8630
UBB	8429
ANAPC15	8289
CDC26	8112
ANAPC2	8085
ANAPC4	8042
CDK1	7905
ANAPC10	7872
UBA52	7750
UBE2S	7726
UBE2E1	7712
RPS27A	7616
UBE2C	7218
CDC20	5696
ANAPC16	5006
UBC	3044
CDC23	1301
UBE2D1	-174
ANAPC1	-6898
CDC27	-8289

---

Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling

	748
set	Negative regulation of NOTCH4 signaling
setSize	54
pANOVA	2.35e-14
s.dist	0.6
p.adjustANOVA	5.74e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RBX1	9572
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RBX1	9572
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CUL1	8089
SKP1	8006
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
TACC3	5218
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
FBXW7	1514
PSMD5	122
AKT1	-411
NOTCH4	-644
YWHAZ	-2370
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935

---

Autodegradation of Cdh1 by Cdh1:APC/C

Autodegradation of Cdh1 by Cdh1:APC/C

	100
set	Autodegradation of Cdh1 by Cdh1:APC/C
setSize	64
pANOVA	1.29e-16
s.dist	0.598
p.adjustANOVA	3.73e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
UBE2C	7218
PSMC4	6376
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
FZR1	-5837
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

DCC mediated attractive signaling

DCC mediated attractive signaling

	245
set	DCC mediated attractive signaling
setSize	13
pANOVA	0.000196
s.dist	-0.597
p.adjustANOVA	0.00101

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DOCK1	-9000
ABLIM1	-8927
PTK2	-8383
WASL	-8227
FYN	-7914
RAC1	-6585
TRIO	-6145
ABLIM3	-4974
NTN1	-4344
CDC42	-3125
NCK1	-1766
SRC	-685
ABLIM2	92

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DOCK1	-9000
ABLIM1	-8927
PTK2	-8383
WASL	-8227
FYN	-7914
RAC1	-6585
TRIO	-6145
ABLIM3	-4974
NTN1	-4344
CDC42	-3125
NCK1	-1766
SRC	-685
ABLIM2	92

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	611
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	109
pANOVA	4.83e-27
s.dist	0.596
p.adjustANOVA	3.49e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
EIF4A2	8438
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
EIF4A1	8031
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
EIF3K	7542
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
EIF3I	7000
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
EIF3M	6690
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
EIF4E	6119
RPS15	5904
EIF3H	5898
EIF3J	5593
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
EIF3E	5377
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
EIF3L	3206
EIF3D	2366
EIF2S1	1682
RPL36AL	1593
EIF3B	1164
EIF3G	767
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EIF3F	-1567
EIF4H	-2020
EIF3C	-3076
EIF1AX	-5520
EIF3A	-5646
EIF4G1	-5703
EIF4B	-8433
EIF2S3	-8439
PABPC1	-8891

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	1080
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	59
pANOVA	2.41e-15
s.dist	0.596
p.adjustANOVA	6.44e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
CDK2	9424
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
CKS1B	8650
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
CDK2	9424
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
CKS1B	8650
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CUL1	8089
CDKN1A	8045
SKP1	8006
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
CDK4	7179
CCNE1	7109
PSMC4	6376
CCNE2	5713
PSMD1	5370
PSMD2	5034
PSMB10	4856
CCNA2	4481
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
PTK6	1887
CCND1	641
PSMD5	122
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
SKP2	-6750
CDKN1B	-6871
PSMF1	-7935

---

CDK-mediated phosphorylation and removal of Cdc6

CDK-mediated phosphorylation and removal of Cdc6

	133
set	CDK-mediated phosphorylation and removal of Cdc6
setSize	70
pANOVA	6.89e-18
s.dist	0.595
p.adjustANOVA	2.31e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
CDK2	9424
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
CDK2	9424
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
ANAPC2	8085
ANAPC4	8042
CDC6	7974
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
UBE2C	7218
CCNE1	7109
PSMC4	6376
CCNE2	5713
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
CCNA2	4481
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
FZR1	-5837
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G

	1394
set	Vif-mediated degradation of APOBEC3G
setSize	52
pANOVA	1.19e-13
s.dist	0.594
p.adjustANOVA	2.62e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RBX1	9572
PSMA5	9551
PSMA2	9545
ELOC	9449
ELOB	9447
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RBX1	9572
PSMA5	9551
PSMA2	9545
ELOC	9449
ELOB	9447
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
APOBEC3G	-3686
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935
CUL5	-8361

---

APC-Cdc20 mediated degradation of Nek2A

APC-Cdc20 mediated degradation of Nek2A

	12
set	APC-Cdc20 mediated degradation of Nek2A
setSize	26
pANOVA	1.68e-07
s.dist	0.593
p.adjustANOVA	1.52e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC5	9531
ANAPC11	9491
ANAPC7	9379
CDC16	8983
UBB	8429
ANAPC15	8289
CDC26	8112
ANAPC2	8085
ANAPC4	8042
BUB3	8013
ANAPC10	7872
UBA52	7750
UBE2S	7726
UBE2E1	7712
RPS27A	7616
MAD2L1	7498
UBE2C	7218
BUB1B	5697
CDC20	5696
ANAPC16	5006

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC5	9531
ANAPC11	9491
ANAPC7	9379
CDC16	8983
UBB	8429
ANAPC15	8289
CDC26	8112
ANAPC2	8085
ANAPC4	8042
BUB3	8013
ANAPC10	7872
UBA52	7750
UBE2S	7726
UBE2E1	7712
RPS27A	7616
MAD2L1	7498
UBE2C	7218
BUB1B	5697
CDC20	5696
ANAPC16	5006
NEK2	4335
UBC	3044
CDC23	1301
UBE2D1	-174
ANAPC1	-6898
CDC27	-8289

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

	1031
set	Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize	48
pANOVA	1.63e-12
s.dist	0.589
p.adjustANOVA	3.09e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935
PAK2	-8921

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	151
set	Cap-dependent Translation Initiation
setSize	117
pANOVA	4.87e-28
s.dist	0.587
p.adjustANOVA	4.14e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
EIF2B1	9401
RPL23A	9334
EIF2B5	9317
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
EIF2B1	9401
RPL23A	9334
EIF2B5	9317
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
EIF4A2	8438
RPL6	8419
EIF2B4	8331
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
EIF4EBP1	8083
EIF4A1	8031
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
EIF3K	7542
EIF2B3	7541
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
EIF3I	7000
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
EIF3M	6690
EIF2B2	6535
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
EIF4E	6119
RPS15	5904
EIF3H	5898
EIF3J	5593
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
EIF3E	5377
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
EIF3L	3206
EIF3D	2366
EIF2S1	1682
RPL36AL	1593
EIF3B	1164
EIF3G	767
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EIF3F	-1567
EIF4H	-2020
EIF3C	-3076
EIF1AX	-5520
EIF3A	-5646
EIF4G1	-5703
EIF5	-6437
EIF5B	-7299
EIF4B	-8433
EIF2S3	-8439
PABPC1	-8891

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	369
set	Eukaryotic Translation Initiation
setSize	117
pANOVA	4.87e-28
s.dist	0.587
p.adjustANOVA	4.14e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
EIF2B1	9401
RPL23A	9334
EIF2B5	9317
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
EIF2B1	9401
RPL23A	9334
EIF2B5	9317
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
EIF4A2	8438
RPL6	8419
EIF2B4	8331
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
EIF4EBP1	8083
EIF4A1	8031
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
EIF3K	7542
EIF2B3	7541
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
EIF3I	7000
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
EIF3M	6690
EIF2B2	6535
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
EIF4E	6119
RPS15	5904
EIF3H	5898
EIF3J	5593
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
EIF3E	5377
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
EIF3L	3206
EIF3D	2366
EIF2S1	1682
RPL36AL	1593
EIF3B	1164
EIF3G	767
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EIF3F	-1567
EIF4H	-2020
EIF3C	-3076
EIF1AX	-5520
EIF3A	-5646
EIF4G1	-5703
EIF5	-6437
EIF5B	-7299
EIF4B	-8433
EIF2S3	-8439
PABPC1	-8891

---

Purine catabolism

Purine catabolism

	897
set	Purine catabolism
setSize	13
pANOVA	0.000248
s.dist	0.587
p.adjustANOVA	0.00126

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUDT5	9489
ITPA	9440
PNP	9208
NT5C	8527
NUDT1	7695
ADPRM	6810
DNPH1	6389
NT5E	5958
NUDT9	5918
NUDT18	2459
NUDT15	2232
NT5C2	2021
NUDT16	-2057

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUDT5	9489
ITPA	9440
PNP	9208
NT5C	8527
NUDT1	7695
ADPRM	6810
DNPH1	6389
NT5E	5958
NUDT9	5918
NUDT18	2459
NUDT15	2232
NT5C2	2021
NUDT16	-2057

---

Regulation of APC/C activators between G1/S and early anaphase

Regulation of APC/C activators between G1/S and early anaphase

	999
set	Regulation of APC/C activators between G1/S and early anaphase
setSize	78
pANOVA	3.16e-19
s.dist	0.587
p.adjustANOVA	1.17e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
CDK2	9424
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
ANAPC5	9531
ANAPC11	9491
PSMA1	9433
CDK2	9424
SEM1	9416
PSMB4	9384
ANAPC7	9379
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
CDC16	8983
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
ANAPC15	8289
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDC26	8112
CUL1	8089
ANAPC2	8085
ANAPC4	8042
BUB3	8013
SKP1	8006
CDK1	7905
ANAPC10	7872
PSMC3	7819
UBA52	7750
UBE2S	7726
UBE2E1	7712
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
MAD2L1	7498
PSMA7	7461
UBE2C	7218
PSMC4	6376
BUB1B	5697
CDC20	5696
PLK1	5577
PSMD1	5370
PSMD2	5034
ANAPC16	5006
PSMB10	4856
CCNA2	4481
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CDC23	1301
PSMD5	122
UBE2D1	-174
FBXO5	-630
PSME4	-1750
PSME3	-2956
PSMB2	-2981
BTRC	-4064
PSMD3	-4182
PSMD11	-4566
FZR1	-5837
ANAPC1	-6898
PSMF1	-7935
CDC27	-8289

---

The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint

	1311
set	The role of GTSE1 in G2/M progression after G2 checkpoint
setSize	58
pANOVA	1.07e-14
s.dist	0.586
p.adjustANOVA	2.73e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
CCNB1	8630
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CDKN1A	8045
CDK1	7905
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
CCNB2	7293
PSMC4	6376
MAPRE1	6047
PLK1	5577
PSMD1	5370
PSMD2	5034
PSMB10	4856
GTSE1	4494
FKBPL	4219
PSMB8	3402
HSP90AB1	3221
UBC	3044
PSMD12	2826
PSMB9	1901
PSMD5	122
HSP90AA1	-673
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935
TP53	-8125

---

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

	375
set	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
setSize	53
pANOVA	1.48e-13
s.dist	0.586
p.adjustANOVA	3.2e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RBX1	9572
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RBX1	9572
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
CUL1	8089
SKP1	8006
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
PSMD2	5034
AURKA	4878
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
FBXL7	-3528
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935
FBXL18	-8768

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	453
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	110
pANOVA	2.15e-26
s.dist	0.586
p.adjustANOVA	1.48e-24

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS27L	9573
RPS13	9507
RPS15A	9506
RPL34	9423
RPL23A	9334
RPL26L1	9297
RPL7	9275
RPS19	9271
RPL17	9191
RPS12	9186
RPLP0	9172
RPS3A	9171
RPL10	9128
RPL22L1	9081
RPL39	9054
RPS5	9009
RPL30	8843
RPL41	8812
RPL31	8793
EIF2S2	8786
RPS3	8783
RPL29	8755
RPSA	8710
RPL26	8694
RPL23	8673
RPS4Y1	8656
RPS10	8613
RPL21	8609
RPS23	8581
RPS17	8560
RPS18	8547
RPS9	8512
RPL10A	8463
RPL18	8453
EIF4A2	8438
RPL6	8419
RPS21	8271
RPL7A	8262
RPL3	8130
RPL37A	8128
EIF4A1	8031
RPL11	7997
FAU	7952
RPL13A	7869
RPL37	7790
UBA52	7750
RPS8	7718
RPS27A	7616
RPL24	7590
RPL22	7554
EIF3K	7542
RPL35A	7451
RPL27	7431
RPS14	7386
RPS6	7288
RPS7	7136
EIF3I	7000
RPS20	6986
RPL14	6953
RPL35	6920
RPS4X	6876
EIF3M	6690
RPL8	6487
RPL27A	6369
RPL12	6341
RPL15	6241
RPS24	6235
RPS16	6182
RPL5	6165
RPS28	6127
EIF4E	6119
RPS15	5904
EIF3H	5898
EIF3J	5593
RPL18A	5543
RPL4	5504
RPL19	5473
RPS2	5410
EIF3E	5377
RPL32	5306
RPL36A	5202
RPL39L	4823
RPL28	4732
RPS25	4699
RPLP1	4629
RPL13	3989
RPS27	3963
RPS29	3810
RPS11	3631
RPL38	3471
EIF3L	3206
EIF3D	2366
EIF2S1	1682
RPL36AL	1593
EIF3B	1164
EIF3G	767
RPS26	365
RPLP2	348
RPL36	-106
RPL9	-732
EIF3F	-1567
EIF4H	-2020
EIF3C	-3076
EIF1AX	-5520
EIF3A	-5646
EIF4G1	-5703
EIF5	-6437
EIF5B	-7299
EIF4B	-8433
EIF2S3	-8439

---

Phosphorylation of the APC/C

Phosphorylation of the APC/C

	849
set	Phosphorylation of the APC/C
setSize	20
pANOVA	6.01e-06
s.dist	0.585
p.adjustANOVA	4.38e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ANAPC5	9531
ANAPC11	9491
ANAPC7	9379
CDC16	8983
CCNB1	8630
ANAPC15	8289
CDC26	8112
ANAPC2	8085
ANAPC4	8042
CDK1	7905
ANAPC10	7872
UBE2S	7726
UBE2E1	7712
UBE2C	7218
PLK1	5577
ANAPC16	5006
CDC23	1301
UBE2D1	-174
ANAPC1	-6898
CDC27	-8289

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ANAPC5	9531
ANAPC11	9491
ANAPC7	9379
CDC16	8983
CCNB1	8630
ANAPC15	8289
CDC26	8112
ANAPC2	8085
ANAPC4	8042
CDK1	7905
ANAPC10	7872
UBE2S	7726
UBE2E1	7712
UBE2C	7218
PLK1	5577
ANAPC16	5006
CDC23	1301
UBE2D1	-174
ANAPC1	-6898
CDC27	-8289

---

CDT1 association with the CDC6:ORC:origin complex

CDT1 association with the CDC6:ORC:origin complex

	134
set	CDT1 association with the CDC6:ORC:origin complex
setSize	57
pANOVA	2.31e-14
s.dist	0.584
p.adjustANOVA	5.74e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
GMNN	8231
PSME2	8183
PSMD8	8126
CDC6	7974
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
ORC6	7129
ORC5	6585
PSMC4	6376
ORC3	5934
PSMD1	5370
PSMD2	5034
PSMB10	4856
ORC2	3625
CDT1	3623
ORC1	3577
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
PSMD5	122
PSME4	-1750
ORC4	-2555
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
MCM8	-4430
PSMD11	-4566
PSMF1	-7935

---

Signaling by NODAL

Signaling by NODAL

	1183
set	Signaling by NODAL
setSize	14
pANOVA	0.000159
s.dist	-0.583
p.adjustANOVA	0.000835

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FOXO3	-8848
SMAD3	-8651
ACVR2B	-8581
SMAD4	-8295
MAPK1	-8046
PCSK6	-7795
MAPK3	-6940
FURIN	-5794
ACVR1B	-5666
SMAD2	-3477
ACVR2A	-2883
ACVR1C	-1146
DRAP1	-50
LEFTY2	2609

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FOXO3	-8848
SMAD3	-8651
ACVR2B	-8581
SMAD4	-8295
MAPK1	-8046
PCSK6	-7795
MAPK3	-6940
FURIN	-5794
ACVR1B	-5666
SMAD2	-3477
ACVR2A	-2883
ACVR1C	-1146
DRAP1	-50
LEFTY2	2609

---

Vpu mediated degradation of CD4

Vpu mediated degradation of CD4

	1401
set	Vpu mediated degradation of CD4
setSize	50
pANOVA	1.06e-12
s.dist	0.582
p.adjustANOVA	2.1e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
SKP1	8006
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
PSMC4	6376
PSMD1	5370
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
BTRC	-4064
PSMD3	-4182
PSMD11	-4566
CD4	-4768
PSMF1	-7935

---

Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D

	1382
set	Ubiquitin-dependent degradation of Cyclin D
setSize	50
pANOVA	1.12e-12
s.dist	0.581
p.adjustANOVA	2.16e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMA5	9551
PSMA2	9545
PSMA1	9433
SEM1	9416
PSMB4	9384
PSMD9	9346
PSMD10	9337
PSMB3	9309
PSMB5	9068
PSMB7	9066
PSMD13	9065
PSMD6	8942
PSMC2	8761
PSMA3	8670
PSMD14	8599
PSMD4	8501
PSMD7	8457
UBB	8429
PSMC1	8410
PSMA6	8385
PSMB1	8338
PSMC6	8270
PSMA4	8263
PSME2	8183
PSMD8	8126
PSMC3	7819
UBA52	7750
PSMC5	7652
PSMB6	7645
RPS27A	7616
PSME1	7584
PSMA7	7461
CDK4	7179
PSMC4	6376
PSMD1	5370
PSMD2	5034
PSMB10	4856
PSMB8	3402
UBC	3044
PSMD12	2826
PSMB9	1901
CCND1	641
PSMD5	122
PSME4	-1750
PSME3	-2956
PSMB2	-2981
PSMD3	-4182
PSMD11	-4566
PSMF1	-7935
GSK3B	-8944

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.2 (2021-11-01)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.1               GGally_2.1.2               
##  [3] beeswarm_0.4.0              gtools_3.9.2               
##  [5] echarts4r_0.4.1             R.utils_2.10.1             
##  [7] R.oo_1.24.0                 R.methodsS3_1.8.1          
##  [9] kableExtra_1.3.4            topconfects_1.8.0          
## [11] limma_3.48.1                eulerr_6.1.0               
## [13] mitch_1.4.0                 MASS_7.3-54                
## [15] fgsea_1.18.0                gplots_3.1.1               
## [17] DESeq2_1.32.0               SummarizedExperiment_1.22.0
## [19] Biobase_2.52.0              MatrixGenerics_1.4.0       
## [21] matrixStats_0.59.0          GenomicRanges_1.44.0       
## [23] GenomeInfoDb_1.28.1         IRanges_2.26.0             
## [25] S4Vectors_0.30.0            BiocGenerics_0.38.0        
## [27] reshape2_1.4.4              forcats_0.5.1              
## [29] stringr_1.4.0               dplyr_1.0.7                
## [31] purrr_0.3.4                 readr_2.0.0                
## [33] tidyr_1.1.3                 tibble_3.1.3               
## [35] ggplot2_3.3.5               tidyverse_1.3.1            
## [37] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.2.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.2      plyr_1.8.6             splines_4.1.2         
##   [7] BiocParallel_1.26.1    digest_0.6.27          htmltools_0.5.1.1     
##  [10] fansi_0.5.0            magrittr_2.0.1         memoise_2.0.0         
##  [13] tzdb_0.1.2             Biostrings_2.60.1      annotate_1.70.0       
##  [16] modelr_0.1.8           svglite_2.0.0          colorspace_2.0-2      
##  [19] blob_1.2.2             rvest_1.0.0            haven_2.4.1           
##  [22] xfun_0.24              crayon_1.4.1           RCurl_1.98-1.3        
##  [25] jsonlite_1.7.2         genefilter_1.74.0      survival_3.2-13       
##  [28] glue_1.4.2             gtable_0.3.0           zlibbioc_1.38.0       
##  [31] XVector_0.32.0         webshot_0.5.2          DelayedArray_0.18.0   
##  [34] scales_1.1.1           DBI_1.1.1              Rcpp_1.0.7            
##  [37] viridisLite_0.4.0      xtable_1.8-4           bit_4.0.4             
##  [40] htmlwidgets_1.5.3      httr_1.4.2             RColorBrewer_1.1-2    
##  [43] ellipsis_0.3.2         pkgconfig_2.0.3        reshape_0.8.8         
##  [46] XML_3.99-0.6           sass_0.4.0             dbplyr_2.1.1          
##  [49] locfit_1.5-9.4         utf8_1.2.2             tidyselect_1.1.1      
##  [52] rlang_0.4.11           later_1.2.0            AnnotationDbi_1.54.1  
##  [55] munsell_0.5.0          cellranger_1.1.0       tools_4.1.2           
##  [58] cachem_1.0.5           cli_3.0.1              generics_0.1.0        
##  [61] RSQLite_2.2.7          broom_0.7.8            evaluate_0.14         
##  [64] fastmap_1.1.0          yaml_2.2.1             knitr_1.33            
##  [67] bit64_4.0.5            fs_1.5.0               caTools_1.18.2        
##  [70] KEGGREST_1.32.0        mime_0.11              xml2_1.3.2            
##  [73] compiler_4.1.2         rstudioapi_0.13        png_0.1-7             
##  [76] reprex_2.0.0           geneplotter_1.70.0     bslib_0.2.5.1         
##  [79] stringi_1.7.3          highr_0.9              desc_1.3.0            
##  [82] lattice_0.20-45        Matrix_1.3-4           vctrs_0.3.8           
##  [85] pillar_1.6.1           lifecycle_1.0.0        jquerylib_0.1.4       
##  [88] data.table_1.14.0      bitops_1.0-7           httpuv_1.6.1          
##  [91] R6_2.5.0               promises_1.2.0.1       KernSmooth_2.23-20    
##  [94] gridExtra_2.3          assertthat_0.2.1       rprojroot_2.0.2       
##  [97] withr_2.4.2            GenomeInfoDbData_1.2.6 hms_1.1.0             
## [100] grid_4.1.2             rmarkdown_2.9          shiny_1.6.0           
## [103] lubridate_1.7.10

END of report