date generated: 2022-10-31

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA -0.3422585
## 7SK        0.9769927
## A1BG       1.7288392
## A2M        0.7132424
## A2MP1     -1.0283753
## A4GALT     0.7239525
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2584
num_genes_in_profile 17399
duplicated_genes_present 0
num_profile_genes_in_sets 8710
num_profile_genes_not_in_sets 8689

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2584
num_genesets_excluded 1111
num_genesets_included 1473

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Eukaryotic Translation Elongation 93 4.09e-29 0.671 6.03e-26
Peptide chain elongation 88 3.13e-27 0.666 1.74e-24
Viral mRNA Translation 88 3.54e-27 0.665 1.74e-24
Selenocysteine synthesis 92 3.09e-25 0.625 6.51e-23
Eukaryotic Translation Termination 92 1.79e-24 0.615 2.64e-22
Unwinding of DNA 12 2.28e-04 -0.614 2.65e-03
Formation of a pool of free 40S subunits 100 3.23e-26 0.612 7.93e-24
Collagen biosynthesis and modifying enzymes 62 1.03e-16 0.609 7.20e-15
CS/DS degradation 11 4.92e-04 0.607 5.18e-03
SARS-CoV-1 modulates host translation machinery 36 4.56e-10 0.600 1.68e-08
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 4.42e-25 0.598 7.87e-23
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 1.73e-23 0.596 1.96e-21
SRP-dependent cotranslational protein targeting to membrane 111 1.23e-26 0.586 4.54e-24
Interleukin-15 signaling 14 1.48e-04 -0.586 1.93e-03
Interleukin-2 signaling 11 7.88e-04 -0.584 7.68e-03
Keratan sulfate degradation 11 8.05e-04 0.583 7.68e-03
Assembly of collagen fibrils and other multimeric structures 51 7.73e-13 0.580 3.56e-11
RIP-mediated NFkB activation via ZBP1 17 4.39e-05 -0.572 6.88e-04
Collagen chain trimerization 40 4.78e-10 0.569 1.72e-08
GTP hydrolysis and joining of the 60S ribosomal subunit 111 4.81e-25 0.567 7.87e-23
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.75e-24 0.558 5.83e-22
Collagen formation 82 5.42e-18 0.552 4.18e-16
Selenoamino acid metabolism 114 4.38e-24 0.548 5.83e-22
Polo-like kinase mediated events 16 2.00e-04 -0.537 2.38e-03
HDMs demethylate histones 21 2.20e-05 -0.535 3.90e-04
FOXO-mediated transcription of cell death genes 16 2.67e-04 -0.526 3.01e-03
Cap-dependent Translation Initiation 118 9.28e-23 0.523 9.11e-21
Eukaryotic Translation Initiation 118 9.28e-23 0.523 9.11e-21
Diseases associated with glycosaminoglycan metabolism 36 1.13e-07 0.511 3.26e-06
CD22 mediated BCR regulation 12 2.88e-03 -0.497 1.97e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 9.87e-10 0.495 3.46e-08
ZBP1(DAI) mediated induction of type I IFNs 20 1.85e-04 -0.483 2.27e-03
Scavenging by Class A Receptors 16 8.81e-04 0.480 8.27e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX) 17 7.34e-04 -0.473 7.31e-03
STAT5 activation downstream of FLT3 ITD mutants 10 9.65e-03 -0.473 5.06e-02
SARS-CoV-2 modulates host translation machinery 49 1.36e-08 0.469 4.35e-07
ECM proteoglycans 50 1.04e-08 0.468 3.39e-07
Regulation of IFNA/IFNB signaling 12 5.23e-03 -0.466 3.18e-02
Growth hormone receptor signaling 20 3.48e-04 -0.462 3.71e-03
GP1b-IX-V activation signalling 10 1.18e-02 -0.460 5.84e-02
Activation of the pre-replicative complex 32 7.42e-06 -0.458 1.44e-04
Transcription of E2F targets under negative control by DREAM complex 19 5.65e-04 -0.457 5.82e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.93e-03 -0.450 3.04e-02
G0 and Early G1 27 5.25e-05 -0.450 8.06e-04
Heme biosynthesis 13 5.13e-03 -0.448 3.13e-02
Dissolution of Fibrin Clot 12 7.30e-03 0.447 4.12e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 9.98e-07 -0.447 2.41e-05
Ribosomal scanning and start codon recognition 58 4.30e-09 0.446 1.44e-07
Regulation of FOXO transcriptional activity by acetylation 10 1.48e-02 -0.445 6.78e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 2.45e-16 0.444 1.57e-14


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Eukaryotic Translation Elongation 93 4.09e-29 0.671000 6.03e-26
Peptide chain elongation 88 3.13e-27 0.666000 1.74e-24
Viral mRNA Translation 88 3.54e-27 0.665000 1.74e-24
Selenocysteine synthesis 92 3.09e-25 0.625000 6.51e-23
Eukaryotic Translation Termination 92 1.79e-24 0.615000 2.64e-22
Unwinding of DNA 12 2.28e-04 -0.614000 2.65e-03
Formation of a pool of free 40S subunits 100 3.23e-26 0.612000 7.93e-24
Collagen biosynthesis and modifying enzymes 62 1.03e-16 0.609000 7.20e-15
CS/DS degradation 11 4.92e-04 0.607000 5.18e-03
SARS-CoV-1 modulates host translation machinery 36 4.56e-10 0.600000 1.68e-08
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 4.42e-25 0.598000 7.87e-23
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 1.73e-23 0.596000 1.96e-21
SRP-dependent cotranslational protein targeting to membrane 111 1.23e-26 0.586000 4.54e-24
Interleukin-15 signaling 14 1.48e-04 -0.586000 1.93e-03
Interleukin-2 signaling 11 7.88e-04 -0.584000 7.68e-03
Keratan sulfate degradation 11 8.05e-04 0.583000 7.68e-03
Assembly of collagen fibrils and other multimeric structures 51 7.73e-13 0.580000 3.56e-11
RIP-mediated NFkB activation via ZBP1 17 4.39e-05 -0.572000 6.88e-04
Collagen chain trimerization 40 4.78e-10 0.569000 1.72e-08
GTP hydrolysis and joining of the 60S ribosomal subunit 111 4.81e-25 0.567000 7.87e-23
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.75e-24 0.558000 5.83e-22
Collagen formation 82 5.42e-18 0.552000 4.18e-16
Selenoamino acid metabolism 114 4.38e-24 0.548000 5.83e-22
Polo-like kinase mediated events 16 2.00e-04 -0.537000 2.38e-03
HDMs demethylate histones 21 2.20e-05 -0.535000 3.90e-04
FOXO-mediated transcription of cell death genes 16 2.67e-04 -0.526000 3.01e-03
Cap-dependent Translation Initiation 118 9.28e-23 0.523000 9.11e-21
Eukaryotic Translation Initiation 118 9.28e-23 0.523000 9.11e-21
Diseases associated with glycosaminoglycan metabolism 36 1.13e-07 0.511000 3.26e-06
CD22 mediated BCR regulation 12 2.88e-03 -0.497000 1.97e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 9.87e-10 0.495000 3.46e-08
ZBP1(DAI) mediated induction of type I IFNs 20 1.85e-04 -0.483000 2.27e-03
Scavenging by Class A Receptors 16 8.81e-04 0.480000 8.27e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX) 17 7.34e-04 -0.473000 7.31e-03
STAT5 activation downstream of FLT3 ITD mutants 10 9.65e-03 -0.473000 5.06e-02
SARS-CoV-2 modulates host translation machinery 49 1.36e-08 0.469000 4.35e-07
ECM proteoglycans 50 1.04e-08 0.468000 3.39e-07
Regulation of IFNA/IFNB signaling 12 5.23e-03 -0.466000 3.18e-02
Growth hormone receptor signaling 20 3.48e-04 -0.462000 3.71e-03
GP1b-IX-V activation signalling 10 1.18e-02 -0.460000 5.84e-02
Activation of the pre-replicative complex 32 7.42e-06 -0.458000 1.44e-04
Transcription of E2F targets under negative control by DREAM complex 19 5.65e-04 -0.457000 5.82e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.93e-03 -0.450000 3.04e-02
G0 and Early G1 27 5.25e-05 -0.450000 8.06e-04
Heme biosynthesis 13 5.13e-03 -0.448000 3.13e-02
Dissolution of Fibrin Clot 12 7.30e-03 0.447000 4.12e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 9.98e-07 -0.447000 2.41e-05
Ribosomal scanning and start codon recognition 58 4.30e-09 0.446000 1.44e-07
Regulation of FOXO transcriptional activity by acetylation 10 1.48e-02 -0.445000 6.78e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 2.45e-16 0.444000 1.57e-14
Nonsense-Mediated Decay (NMD) 114 2.45e-16 0.444000 1.57e-14
Interleukin receptor SHC signaling 23 2.43e-04 -0.442000 2.78e-03
Striated Muscle Contraction 31 2.56e-05 0.437000 4.38e-04
Cellular response to starvation 150 2.62e-20 0.437000 2.41e-18
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.34e-02 -0.431000 6.30e-02
NCAM1 interactions 28 8.84e-05 0.428000 1.24e-03
Translation initiation complex formation 58 1.86e-08 0.427000 5.82e-07
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.33e-03 -0.427000 1.69e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.33e-03 -0.427000 1.69e-02
Maturation of nucleoprotein 9683610 11 1.50e-02 -0.424000 6.84e-02
Regulation of TP53 Activity through Acetylation 29 7.92e-05 -0.423000 1.14e-03
MET activates PTK2 signaling 17 2.60e-03 0.422000 1.81e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.38e-08 0.420000 7.16e-07
PKMTs methylate histone lysines 43 1.97e-06 -0.419000 4.39e-05
Molecules associated with elastic fibres 26 2.28e-04 0.418000 2.65e-03
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 1.68e-02 -0.416000 7.40e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 13 9.66e-03 -0.415000 5.06e-02
Interleukin-2 family signaling 37 1.47e-05 -0.412000 2.67e-04
Expression and translocation of olfactory receptors 31 7.63e-05 0.410000 1.12e-03
FGFR2 ligand binding and activation 10 2.57e-02 0.407000 1.02e-01
Beta-oxidation of very long chain fatty acids 10 2.62e-02 -0.406000 1.03e-01
Elastic fibre formation 36 2.66e-05 0.405000 4.50e-04
Role of LAT2/NTAL/LAB on calcium mobilization 18 2.97e-03 -0.404000 2.03e-02
Interferon alpha/beta signaling 52 4.58e-07 -0.404000 1.20e-05
G1/S-Specific Transcription 29 1.81e-04 -0.402000 2.27e-03
Eicosanoid ligand-binding receptors 14 9.31e-03 -0.401000 4.94e-02
RUNX3 regulates NOTCH signaling 14 9.32e-03 -0.401000 4.94e-02
Regulation of expression of SLITs and ROBOs 163 3.82e-18 0.394000 3.12e-16
Metabolism of porphyrins 21 1.83e-03 -0.393000 1.44e-02
DNA strand elongation 32 1.27e-04 -0.391000 1.70e-03
Erythropoietin activates RAS 13 1.51e-02 -0.389000 6.86e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 1.57e-02 -0.387000 7.10e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 50 2.34e-06 -0.386000 5.10e-05
Complex I biogenesis 51 1.88e-06 0.386000 4.26e-05
Influenza Viral RNA Transcription and Replication 135 1.56e-14 0.383000 9.59e-13
RORA activates gene expression 18 5.57e-03 -0.377000 3.34e-02
Pyrimidine salvage 10 3.88e-02 -0.377000 1.39e-01
Glutathione synthesis and recycling 10 3.97e-02 -0.376000 1.41e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 37 7.71e-05 -0.376000 1.12e-03
Signaling by Erythropoietin 24 1.46e-03 -0.375000 1.20e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 7.70e-03 -0.373000 4.30e-02
eNOS activation 11 3.25e-02 0.372000 1.21e-01
NR1H2 and NR1H3-mediated signaling 41 3.79e-05 -0.372000 6.01e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.61e-02 -0.372000 7.17e-02
Formation of ATP by chemiosmotic coupling 16 1.02e-02 0.371000 5.24e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 1.02e-02 -0.371000 5.24e-02
Defective B3GALTL causes PpS 34 1.85e-04 0.371000 2.27e-03
Transcriptional regulation of granulopoiesis 43 2.69e-05 -0.370000 4.51e-04
Olfactory Signaling Pathway 36 1.24e-04 0.370000 1.69e-03
Signaling by Leptin 11 3.57e-02 -0.366000 1.30e-01
TRAF3-dependent IRF activation pathway 14 1.78e-02 -0.366000 7.76e-02
O-glycosylation of TSR domain-containing proteins 35 1.87e-04 0.365000 2.27e-03
Zinc transporters 13 2.28e-02 0.365000 9.28e-02
Phase 0 - rapid depolarisation 26 1.32e-03 0.364000 1.10e-02
BBSome-mediated cargo-targeting to cilium 21 3.98e-03 0.363000 2.58e-02
Activation of ATR in response to replication stress 37 1.36e-04 -0.363000 1.80e-03
Translation 292 2.22e-26 0.362000 6.53e-24
Regulation of signaling by CBL 18 8.27e-03 -0.360000 4.53e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.03e-02 0.357000 1.63e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 16 1.34e-02 0.357000 6.30e-02
TRAF6 mediated NF-kB activation 24 2.46e-03 -0.357000 1.76e-02
Defective B3GAT3 causes JDSSDHD 16 1.38e-02 0.355000 6.45e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 13 2.81e-02 -0.352000 1.08e-01
alpha-linolenic acid (ALA) metabolism 13 2.81e-02 -0.352000 1.08e-01
Biosynthesis of DHA-derived SPMs 15 1.84e-02 -0.352000 7.93e-02
Biosynthesis of specialized proresolving mediators (SPMs) 17 1.23e-02 -0.351000 5.98e-02
Interleukin-6 signaling 11 4.42e-02 -0.350000 1.50e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.47e-02 -0.350000 1.50e-01
Keratan sulfate biosynthesis 26 2.44e-03 0.343000 1.75e-02
Laminin interactions 22 5.34e-03 0.343000 3.22e-02
Defective B4GALT7 causes EDS, progeroid type 16 1.77e-02 0.342000 7.75e-02
STAT3 nuclear events downstream of ALK signaling 10 6.16e-02 -0.341000 1.88e-01
E2F mediated regulation of DNA replication 22 5.87e-03 -0.339000 3.48e-02
HDR through MMEJ (alt-NHEJ) 12 4.25e-02 -0.338000 1.47e-01
Collagen degradation 34 6.71e-04 0.337000 6.86e-03
RUNX3 regulates p14-ARF 10 6.50e-02 -0.337000 1.96e-01
Respiratory electron transport 93 2.14e-08 0.336000 6.58e-07
Non-integrin membrane-ECM interactions 39 2.84e-04 0.336000 3.13e-03
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 34 7.03e-04 -0.336000 7.10e-03
ABC transporters in lipid homeostasis 14 2.99e-02 -0.335000 1.14e-01
WNT ligand biogenesis and trafficking 20 9.90e-03 0.333000 5.15e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 4.65e-02 -0.332000 1.53e-01
Diseases of hemostasis 12 4.65e-02 -0.332000 1.53e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 3.86e-02 0.331000 1.38e-01
Defective EXT2 causes exostoses 2 13 3.86e-02 0.331000 1.38e-01
MAPK3 (ERK1) activation 10 7.11e-02 -0.330000 2.08e-01
Influenza Infection 154 2.41e-12 0.327000 1.02e-10
Metabolism of steroid hormones 22 7.91e-03 0.327000 4.38e-02
Nuclear Pore Complex (NPC) Disassembly 36 6.99e-04 -0.327000 7.10e-03
Pentose phosphate pathway 13 4.15e-02 -0.326000 1.46e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 2.17e-09 0.326000 7.43e-08
Major pathway of rRNA processing in the nucleolus and cytosol 180 6.11e-14 0.324000 3.33e-12
SUMOylation of DNA replication proteins 46 1.47e-04 -0.324000 1.93e-03
Chondroitin sulfate/dermatan sulfate metabolism 45 1.78e-04 0.323000 2.25e-03
A tetrasaccharide linker sequence is required for GAG synthesis 22 8.77e-03 0.323000 4.77e-02
Condensation of Prometaphase Chromosomes 11 6.43e-02 -0.322000 1.95e-01
Depolymerisation of the Nuclear Lamina 15 3.10e-02 -0.322000 1.17e-01
Keratan sulfate/keratin metabolism 31 2.05e-03 0.320000 1.57e-02
Platelet Aggregation (Plug Formation) 32 1.88e-03 -0.318000 1.47e-02
RAF-independent MAPK1/3 activation 22 1.02e-02 -0.316000 5.24e-02
Nuclear Envelope Breakdown 53 7.07e-05 -0.316000 1.06e-03
Interleukin-20 family signaling 14 4.18e-02 -0.314000 1.46e-01
Aflatoxin activation and detoxification 14 4.23e-02 -0.313000 1.47e-01
Extracellular matrix organization 259 5.67e-18 0.312000 4.18e-16
PD-1 signaling 14 4.44e-02 -0.310000 1.50e-01
SUMOylation of ubiquitinylation proteins 39 8.08e-04 -0.310000 7.68e-03
Signaling by ROBO receptors 206 2.22e-14 0.309000 1.31e-12
Paracetamol ADME 19 2.00e-02 -0.308000 8.41e-02
Activation of gene expression by SREBF (SREBP) 42 5.65e-04 -0.308000 5.82e-03
DNA methylation 17 2.82e-02 -0.307000 1.09e-01
Triglyceride metabolism 24 9.25e-03 -0.307000 4.94e-02
CD28 dependent Vav1 pathway 11 7.80e-02 -0.307000 2.19e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 2.67e-03 -0.307000 1.86e-02
PRC2 methylates histones and DNA 26 6.90e-03 -0.306000 3.94e-02
rRNA processing in the nucleus and cytosol 190 3.71e-13 0.306000 1.82e-11
Synthesis of IP3 and IP4 in the cytosol 24 9.64e-03 -0.305000 5.06e-02
Adherens junctions interactions 24 9.73e-03 0.305000 5.08e-02
Frs2-mediated activation 12 6.81e-02 -0.304000 2.03e-01
Interleukin-7 signaling 21 1.60e-02 -0.304000 7.17e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 4.92e-02 -0.304000 1.60e-01
Vpr-mediated nuclear import of PICs 34 2.21e-03 -0.303000 1.63e-02
Diseases associated with the TLR signaling cascade 28 5.65e-03 -0.302000 3.36e-02
Diseases of Immune System 28 5.65e-03 -0.302000 3.36e-02
Defective pyroptosis 26 7.84e-03 -0.301000 4.36e-02
Signaling by cytosolic FGFR1 fusion mutants 18 2.69e-02 -0.301000 1.05e-01
Phase 4 - resting membrane potential 10 1.03e-01 0.297000 2.61e-01
Mitochondrial translation termination 88 1.43e-06 0.297000 3.34e-05
GPVI-mediated activation cascade 32 3.66e-03 -0.297000 2.42e-02
Mitochondrial translation 94 6.88e-07 0.296000 1.75e-05
Mitochondrial translation initiation 88 1.71e-06 0.295000 3.93e-05
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 4.51e-03 -0.295000 2.85e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 4.51e-03 -0.295000 2.85e-02
NOTCH2 intracellular domain regulates transcription 11 9.14e-02 -0.294000 2.41e-01
Cristae formation 29 6.22e-03 0.294000 3.67e-02
FCERI mediated MAPK activation 34 3.12e-03 -0.293000 2.10e-02
TP53 Regulates Transcription of Caspase Activators and Caspases 12 7.89e-02 -0.293000 2.21e-01
Cargo concentration in the ER 31 4.82e-03 0.293000 3.02e-02
Condensation of Prophase Chromosomes 26 1.00e-02 -0.292000 5.19e-02
Processive synthesis on the lagging strand 15 5.06e-02 -0.292000 1.64e-01
STING mediated induction of host immune responses 15 5.10e-02 -0.291000 1.65e-01
Scavenging of heme from plasma 15 5.14e-02 -0.291000 1.65e-01
TRAF6 mediated IRF7 activation 16 4.47e-02 -0.290000 1.50e-01
RNA Polymerase I Promoter Opening 16 4.48e-02 -0.290000 1.50e-01
Mismatch Repair 15 5.23e-02 -0.289000 1.66e-01
Reduction of cytosolic Ca++ levels 10 1.14e-01 0.289000 2.74e-01
Rev-mediated nuclear export of HIV RNA 35 3.22e-03 -0.288000 2.16e-02
RNA Polymerase I Transcription Termination 30 6.54e-03 0.287000 3.82e-02
NS1 Mediated Effects on Host Pathways 40 1.75e-03 -0.286000 1.39e-02
Unblocking of NMDA receptors, glutamate binding and activation 21 2.39e-02 0.285000 9.63e-02
Regulation of MECP2 expression and activity 30 7.06e-03 -0.284000 4.01e-02
Synthesis of PE 12 8.85e-02 -0.284000 2.37e-01
Intraflagellar transport 39 2.20e-03 0.283000 1.63e-02
Syndecan interactions 19 3.25e-02 0.283000 1.21e-01
Mitochondrial translation elongation 88 4.42e-06 0.283000 9.04e-05
NEP/NS2 Interacts with the Cellular Export Machinery 32 5.58e-03 -0.283000 3.34e-02
Export of Viral Ribonucleoproteins from Nucleus 33 4.97e-03 -0.283000 3.05e-02
TP53 Regulates Transcription of Cell Cycle Genes 47 8.35e-04 -0.282000 7.89e-03
Receptor-type tyrosine-protein phosphatases 15 5.93e-02 0.281000 1.83e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 3.60e-03 -0.280000 2.39e-02
Prolonged ERK activation events 14 6.98e-02 -0.280000 2.06e-01
Transcriptional regulation of white adipocyte differentiation 84 9.89e-06 -0.279000 1.87e-04
FLT3 Signaling 38 3.00e-03 -0.278000 2.03e-02
Costimulation by the CD28 family 58 2.48e-04 -0.278000 2.81e-03
rRNA processing 200 1.23e-11 0.278000 5.05e-10
Signaling by high-kinase activity BRAF mutants 31 7.38e-03 -0.278000 4.15e-02
Chromatin modifying enzymes 215 2.23e-12 -0.278000 9.67e-11
Chromatin organization 215 2.23e-12 -0.278000 9.67e-11
Platelet Adhesion to exposed collagen 13 8.28e-02 -0.278000 2.28e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.63e-03 -0.278000 1.31e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.89e-03 -0.277000 1.47e-02
Insulin receptor recycling 23 2.16e-02 0.277000 8.95e-02
Nitric oxide stimulates guanylate cyclase 20 3.25e-02 0.276000 1.21e-01
Acyl chain remodelling of PI 12 9.80e-02 0.276000 2.51e-01
Early Phase of HIV Life Cycle 14 7.41e-02 -0.276000 2.14e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.44e-02 -0.275000 2.14e-01
CASP8 activity is inhibited 11 1.14e-01 -0.275000 2.74e-01
Dimerization of procaspase-8 11 1.14e-01 -0.275000 2.74e-01
Regulation by c-FLIP 11 1.14e-01 -0.275000 2.74e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 29 1.05e-02 -0.274000 5.35e-02
Amino acid transport across the plasma membrane 23 2.28e-02 -0.274000 9.28e-02
Signaling by FLT3 ITD and TKD mutants 16 5.78e-02 -0.274000 1.78e-01
Pre-NOTCH Transcription and Translation 46 1.33e-03 -0.274000 1.10e-02
Metal ion SLC transporters 22 2.75e-02 0.272000 1.07e-01
Processing of Intronless Pre-mRNAs 20 3.63e-02 -0.270000 1.32e-01
Activation of BH3-only proteins 29 1.21e-02 -0.269000 5.90e-02
Resolution of D-Loop Structures 34 6.73e-03 -0.269000 3.88e-02
Generation of second messenger molecules 24 2.31e-02 -0.268000 9.33e-02
Interactions of Rev with host cellular proteins 37 4.90e-03 -0.267000 3.03e-02
Chaperone Mediated Autophagy 19 4.37e-02 0.267000 1.50e-01
Activation of Matrix Metalloproteinases 26 1.84e-02 0.267000 7.93e-02
Cyclin A/B1/B2 associated events during G2/M transition 25 2.08e-02 -0.267000 8.66e-02
WNT5A-dependent internalization of FZD4 14 8.38e-02 -0.267000 2.29e-01
Gap junction trafficking and regulation 19 4.53e-02 0.265000 1.50e-01
Long-term potentiation 23 2.88e-02 0.263000 1.10e-01
Chondroitin sulfate biosynthesis 16 6.89e-02 0.263000 2.05e-01
ERKs are inactivated 13 1.04e-01 -0.260000 2.62e-01
Myogenesis 24 2.76e-02 0.260000 1.07e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 5.68e-02 -0.259000 1.77e-01
Disorders of Developmental Biology 13 1.06e-01 -0.259000 2.64e-01
Disorders of Nervous System Development 13 1.06e-01 -0.259000 2.64e-01
Loss of function of MECP2 in Rett syndrome 13 1.06e-01 -0.259000 2.64e-01
Pervasive developmental disorders 13 1.06e-01 -0.259000 2.64e-01
Interleukin-27 signaling 10 1.56e-01 -0.259000 3.37e-01
Transport of Mature Transcript to Cytoplasm 81 5.78e-05 -0.259000 8.78e-04
Nucleotide biosynthesis 12 1.21e-01 -0.259000 2.86e-01
Nuclear import of Rev protein 34 9.22e-03 -0.258000 4.94e-02
Gap junction trafficking 17 6.56e-02 0.258000 1.98e-01
Lagging Strand Synthesis 20 4.65e-02 -0.257000 1.53e-01
PINK1-PRKN Mediated Mitophagy 21 4.15e-02 0.257000 1.46e-01
DNA Damage/Telomere Stress Induced Senescence 41 4.44e-03 -0.257000 2.84e-02
CD28 co-stimulation 32 1.20e-02 -0.257000 5.89e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 33 1.08e-02 -0.256000 5.46e-02
Phosphorylation of CD3 and TCR zeta chains 13 1.10e-01 -0.256000 2.70e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.73e-04 -0.256000 2.20e-03
RHO GTPases Activate NADPH Oxidases 21 4.24e-02 -0.256000 1.47e-01
ERBB2 Activates PTK6 Signaling 12 1.27e-01 0.255000 2.96e-01
Oxidative Stress Induced Senescence 76 1.27e-04 -0.254000 1.70e-03
SUMOylation of SUMOylation proteins 35 9.27e-03 -0.254000 4.94e-02
Elevation of cytosolic Ca2+ levels 13 1.13e-01 -0.254000 2.74e-01
Interferon gamma signaling 72 2.00e-04 -0.253000 2.38e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 19 5.58e-02 -0.253000 1.75e-01
Transport of the SLBP Dependant Mature mRNA 36 8.62e-03 -0.253000 4.70e-02
TNFR1-induced NFkappaB signaling pathway 26 2.57e-02 -0.253000 1.02e-01
Transport of the SLBP independent Mature mRNA 35 1.00e-02 -0.252000 5.19e-02
mRNA 3’-end processing 57 1.07e-03 -0.251000 9.40e-03
Cell recruitment (pro-inflammatory response) 24 3.37e-02 -0.250000 1.25e-01
Purinergic signaling in leishmaniasis infection 24 3.37e-02 -0.250000 1.25e-01
Oncogene Induced Senescence 33 1.30e-02 -0.250000 6.15e-02
rRNA processing in the mitochondrion 10 1.73e-01 -0.249000 3.60e-01
Other interleukin signaling 22 4.36e-02 -0.249000 1.50e-01
Prolactin receptor signaling 11 1.54e-01 -0.248000 3.34e-01
Cell-cell junction organization 43 4.89e-03 0.248000 3.03e-02
Regulation of KIT signaling 16 8.59e-02 -0.248000 2.34e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 95 3.03e-05 0.248000 5.01e-04
Mitotic Prophase 95 3.25e-05 -0.247000 5.31e-04
Translocation of ZAP-70 to Immunological synapse 10 1.78e-01 -0.246000 3.67e-01
Telomere C-strand (Lagging Strand) Synthesis 34 1.37e-02 -0.244000 6.42e-02
Signal regulatory protein family interactions 12 1.43e-01 -0.244000 3.20e-01
Post-translational protein phosphorylation 83 1.22e-04 0.244000 1.68e-03
Removal of the Flap Intermediate 14 1.15e-01 -0.244000 2.75e-01
FGFR2 mutant receptor activation 24 3.95e-02 0.243000 1.40e-01
mRNA Capping 29 2.42e-02 0.242000 9.74e-02
Integrin signaling 24 4.18e-02 -0.240000 1.46e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.50e-01 -0.240000 3.29e-01
Folding of actin by CCT/TriC 10 1.90e-01 0.239000 3.85e-01
Diseases of glycosylation 125 4.04e-06 0.239000 8.38e-05
Meiotic recombination 35 1.47e-02 -0.238000 6.78e-02
SUMOylation of intracellular receptors 27 3.25e-02 -0.238000 1.21e-01
SUMOylation 167 1.23e-07 -0.237000 3.47e-06
Killing mechanisms 10 1.94e-01 -0.237000 3.86e-01
WNT5:FZD7-mediated leishmania damping 10 1.94e-01 -0.237000 3.86e-01
SUMO E3 ligases SUMOylate target proteins 161 2.21e-07 -0.237000 6.16e-06
Meiosis 60 1.53e-03 -0.237000 1.24e-02
Signaling by FGFR2 IIIa TM 19 7.54e-02 0.236000 2.15e-01
Germ layer formation at gastrulation 12 1.58e-01 0.235000 3.39e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 67 9.22e-04 -0.234000 8.60e-03
Synthesis of PC 25 4.29e-02 -0.234000 1.48e-01
Diseases associated with O-glycosylation of proteins 55 2.71e-03 0.234000 1.87e-02
Extension of Telomeres 50 4.24e-03 -0.234000 2.73e-02
TAK1-dependent IKK and NF-kappa-B activation 43 8.09e-03 -0.233000 4.45e-02
Regulation of PTEN mRNA translation 13 1.45e-01 -0.233000 3.23e-01
Meiotic synapsis 39 1.17e-02 -0.233000 5.84e-02
Beta-catenin phosphorylation cascade 17 9.62e-02 -0.233000 2.48e-01
RMTs methylate histone arginines 37 1.47e-02 -0.232000 6.78e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 3.77e-02 0.231000 1.36e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.77e-02 0.231000 1.36e-01
Fanconi Anemia Pathway 36 1.65e-02 -0.231000 7.30e-02
Initiation of Nuclear Envelope (NE) Reformation 19 8.17e-02 -0.231000 2.26e-01
Maturation of nucleoprotein 9694631 15 1.22e-01 -0.230000 2.87e-01
The citric acid (TCA) cycle and respiratory electron transport 160 5.06e-07 0.230000 1.31e-05
Signaling by BMP 24 5.31e-02 0.228000 1.68e-01
AURKA Activation by TPX2 71 9.53e-04 -0.227000 8.83e-03
CD28 dependent PI3K/Akt signaling 21 7.23e-02 -0.227000 2.11e-01
Pregnenolone biosynthesis 11 1.95e-01 0.226000 3.87e-01
activated TAK1 mediates p38 MAPK activation 19 8.84e-02 -0.226000 2.37e-01
Interleukin-35 Signalling 12 1.76e-01 -0.225000 3.65e-01
Activation of the AP-1 family of transcription factors 10 2.17e-01 -0.225000 4.12e-01
Interactions of Vpr with host cellular proteins 37 1.80e-02 -0.225000 7.80e-02
Signaling by SCF-KIT 42 1.18e-02 -0.224000 5.85e-02
AKT phosphorylates targets in the nucleus 10 2.20e-01 -0.224000 4.13e-01
Platelet sensitization by LDL 17 1.11e-01 -0.224000 2.70e-01
Metabolism of cofactors 19 9.19e-02 0.223000 2.41e-01
RAS processing 19 9.26e-02 0.223000 2.42e-01
Signaling by RAF1 mutants 36 2.07e-02 -0.223000 8.65e-02
Mitochondrial protein import 63 2.25e-03 0.223000 1.65e-02
Formation of the beta-catenin:TCF transactivating complex 43 1.17e-02 -0.222000 5.82e-02
APC truncation mutants have impaired AXIN binding 14 1.51e-01 -0.222000 3.29e-01
AXIN missense mutants destabilize the destruction complex 14 1.51e-01 -0.222000 3.29e-01
Signaling by AMER1 mutants 14 1.51e-01 -0.222000 3.29e-01
Signaling by APC mutants 14 1.51e-01 -0.222000 3.29e-01
Signaling by AXIN mutants 14 1.51e-01 -0.222000 3.29e-01
Truncations of AMER1 destabilize the destruction complex 14 1.51e-01 -0.222000 3.29e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 29 3.90e-02 -0.221000 1.39e-01
HCMV Early Events 73 1.09e-03 -0.221000 9.50e-03
Diseases of programmed cell death 57 3.97e-03 -0.221000 2.58e-02
Glycosaminoglycan metabolism 107 8.36e-05 0.220000 1.20e-03
Aspartate and asparagine metabolism 10 2.29e-01 0.220000 4.20e-01
Inwardly rectifying K+ channels 26 5.24e-02 0.220000 1.66e-01
Regulation of TP53 Activity 154 2.63e-06 -0.219000 5.61e-05
Biotin transport and metabolism 11 2.08e-01 -0.219000 3.99e-01
TNFR1-induced proapoptotic signaling 13 1.72e-01 -0.219000 3.60e-01
Gastrulation 17 1.18e-01 0.219000 2.82e-01
MAP2K and MAPK activation 35 2.57e-02 -0.218000 1.02e-01
DNA Double-Strand Break Repair 138 1.03e-05 -0.218000 1.92e-04
Centrosome maturation 80 8.05e-04 -0.217000 7.68e-03
Recruitment of mitotic centrosome proteins and complexes 80 8.05e-04 -0.217000 7.68e-03
Loss of Nlp from mitotic centrosomes 68 2.03e-03 -0.217000 1.56e-02
Loss of proteins required for interphase microtubule organization from the centrosome 68 2.03e-03 -0.217000 1.56e-02
Processive synthesis on the C-strand of the telomere 19 1.03e-01 -0.216000 2.60e-01
Regulation of IFNG signaling 14 1.62e-01 -0.216000 3.45e-01
Metabolism of amino acids and derivatives 320 3.56e-11 0.216000 1.35e-09
Telomere C-strand synthesis initiation 13 1.79e-01 -0.215000 3.69e-01
Activation of G protein gated Potassium channels 21 8.84e-02 0.215000 2.37e-01
G protein gated Potassium channels 21 8.84e-02 0.215000 2.37e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 21 8.84e-02 0.215000 2.37e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 1.88e-02 -0.215000 7.96e-02
Signaling by RAS mutants 40 1.88e-02 -0.215000 7.96e-02
Signaling by moderate kinase activity BRAF mutants 40 1.88e-02 -0.215000 7.96e-02
Signaling downstream of RAS mutants 40 1.88e-02 -0.215000 7.96e-02
FOXO-mediated transcription 59 4.47e-03 -0.214000 2.85e-02
Recruitment of NuMA to mitotic centrosomes 79 1.02e-03 -0.214000 9.22e-03
SUMOylation of immune response proteins 11 2.19e-01 -0.214000 4.13e-01
Transcriptional Regulation by E2F6 34 3.10e-02 -0.214000 1.17e-01
Repression of WNT target genes 14 1.67e-01 -0.214000 3.53e-01
CRMPs in Sema3A signaling 15 1.52e-01 0.213000 3.31e-01
Triglyceride catabolism 16 1.39e-01 -0.213000 3.14e-01
Cytosolic tRNA aminoacylation 24 7.08e-02 0.213000 2.08e-01
Regulation of NPAS4 gene expression 12 2.02e-01 -0.213000 3.97e-01
EML4 and NUDC in mitotic spindle formation 96 3.19e-04 -0.213000 3.43e-03
Interferon Signaling 166 2.35e-06 -0.212000 5.10e-05
RNA Polymerase II Transcription Termination 66 2.88e-03 -0.212000 1.97e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 6.65e-02 -0.212000 2.00e-01
IRF3-mediated induction of type I IFN 12 2.04e-01 -0.212000 3.98e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 6.16e-02 -0.212000 1.88e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 6.67e-03 -0.212000 3.87e-02
CLEC7A (Dectin-1) induces NFAT activation 11 2.25e-01 0.211000 4.17e-01
SUMOylation of RNA binding proteins 47 1.22e-02 -0.211000 5.94e-02
Cytosolic sensors of pathogen-associated DNA 63 3.76e-03 -0.211000 2.46e-02
Translation of Structural Proteins 9683701 29 4.95e-02 -0.211000 1.61e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 107 1.70e-04 -0.210000 2.18e-03
Antiviral mechanism by IFN-stimulated genes 80 1.15e-03 -0.210000 9.78e-03
SARS-CoV-2 activates/modulates innate and adaptive immune responses 99 3.03e-04 -0.210000 3.29e-03
Acyl chain remodelling of PG 13 1.90e-01 0.210000 3.85e-01
Mitotic Prometaphase 185 8.68e-07 -0.210000 2.13e-05
AKT phosphorylates targets in the cytosol 14 1.74e-01 -0.210000 3.62e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 11 2.29e-01 0.210000 4.20e-01
NOTCH3 Intracellular Domain Regulates Transcription 23 8.20e-02 -0.210000 2.26e-01
Notch-HLH transcription pathway 28 5.59e-02 -0.209000 1.75e-01
Aspirin ADME 15 1.62e-01 -0.208000 3.45e-01
Assembly of the ORC complex at the origin of replication 22 9.12e-02 -0.208000 2.41e-01
RUNX2 regulates bone development 30 4.87e-02 0.208000 1.59e-01
Cellular Senescence 140 2.26e-05 -0.208000 3.96e-04
SUMOylation of chromatin organization proteins 57 6.83e-03 -0.207000 3.92e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 1.67e-01 0.206000 3.54e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 1.67e-01 0.206000 3.54e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 3.26e-02 -0.206000 1.21e-01
LGI-ADAM interactions 10 2.61e-01 0.205000 4.51e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 8.87e-02 -0.205000 2.37e-01
Regulation of NF-kappa B signaling 18 1.32e-01 -0.205000 3.02e-01
Reproduction 70 3.05e-03 -0.205000 2.06e-02
RUNX2 regulates osteoblast differentiation 23 9.04e-02 0.204000 2.39e-01
HATs acetylate histones 92 7.44e-04 -0.204000 7.36e-03
Creation of C4 and C2 activators 17 1.47e-01 -0.203000 3.26e-01
The role of Nef in HIV-1 replication and disease pathogenesis 26 7.29e-02 -0.203000 2.11e-01
Synthesis of pyrophosphates in the cytosol 10 2.67e-01 -0.203000 4.54e-01
Trafficking and processing of endosomal TLR 13 2.07e-01 -0.202000 3.98e-01
Homology Directed Repair 108 2.93e-04 -0.202000 3.20e-03
Ion homeostasis 46 1.80e-02 0.202000 7.80e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 2.27e-01 -0.202000 4.18e-01
Classical antibody-mediated complement activation 14 1.94e-01 -0.201000 3.86e-01
Signaling by WNT in cancer 30 5.72e-02 -0.201000 1.78e-01
MET promotes cell motility 27 7.14e-02 0.201000 2.09e-01
IRS-related events triggered by IGF1R 40 2.90e-02 -0.200000 1.11e-01
PCNA-Dependent Long Patch Base Excision Repair 21 1.13e-01 -0.200000 2.74e-01
Signaling by PDGFRA extracellular domain mutants 12 2.31e-01 -0.200000 4.22e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.31e-01 -0.200000 4.22e-01
Transport of vitamins, nucleosides, and related molecules 32 5.15e-02 0.199000 1.65e-01
IGF1R signaling cascade 41 2.76e-02 -0.199000 1.07e-01
Inflammasomes 21 1.15e-01 -0.199000 2.75e-01
SUMOylation of DNA methylation proteins 16 1.69e-01 -0.199000 3.56e-01
Cargo trafficking to the periciliary membrane 46 1.99e-02 0.198000 8.39e-02
Deadenylation of mRNA 22 1.07e-01 -0.198000 2.65e-01
Muscle contraction 160 1.55e-05 0.198000 2.79e-04
Regulation of lipid metabolism by PPARalpha 107 4.07e-04 -0.198000 4.31e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 92 1.04e-03 -0.198000 9.22e-03
Amplification of signal from the kinetochores 92 1.04e-03 -0.198000 9.22e-03
Peroxisomal lipid metabolism 27 7.57e-02 -0.197000 2.15e-01
Activation of SMO 17 1.59e-01 0.197000 3.42e-01
Signaling by PDGF 50 1.59e-02 0.197000 7.17e-02
Nucleotide salvage 22 1.10e-01 -0.197000 2.70e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 20 1.28e-01 0.197000 2.96e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 1.88e-01 0.196000 3.82e-01
Axon guidance 489 1.29e-13 0.196000 6.54e-12
Telomere Extension By Telomerase 22 1.13e-01 -0.195000 2.74e-01
Nervous system development 510 5.29e-14 0.195000 2.99e-12
RHOU GTPase cycle 40 3.44e-02 -0.193000 1.27e-01
mRNA Splicing - Major Pathway 181 8.41e-06 -0.192000 1.61e-04
HCMV Infection 97 1.14e-03 -0.191000 9.78e-03
Regulation of PTEN gene transcription 60 1.05e-02 -0.191000 5.33e-02
Degradation of cysteine and homocysteine 13 2.33e-01 -0.191000 4.25e-01
RHO GTPases activate IQGAPs 11 2.75e-01 -0.190000 4.64e-01
Polymerase switching on the C-strand of the telomere 26 9.35e-02 -0.190000 2.43e-01
ISG15 antiviral mechanism 72 5.32e-03 -0.190000 3.22e-02
Regulation of beta-cell development 23 1.15e-01 -0.190000 2.75e-01
Processing of Capped Intron-Containing Pre-mRNA 240 4.24e-07 -0.190000 1.14e-05
Branched-chain amino acid catabolism 21 1.33e-01 -0.189000 3.03e-01
PPARA activates gene expression 105 8.02e-04 -0.189000 7.68e-03
Cardiac conduction 97 1.28e-03 0.189000 1.08e-02
MASTL Facilitates Mitotic Progression 10 3.01e-01 -0.189000 4.93e-01
Cytosolic iron-sulfur cluster assembly 13 2.39e-01 -0.189000 4.30e-01
Diseases of mitotic cell cycle 38 4.52e-02 -0.188000 1.50e-01
Cell Cycle, Mitotic 500 7.62e-13 -0.188000 3.56e-11
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 1.10e-03 -0.187000 9.55e-03
Nicotinate metabolism 27 9.28e-02 -0.187000 2.42e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 2.85e-01 -0.186000 4.75e-01
GABA synthesis, release, reuptake and degradation 13 2.45e-01 -0.186000 4.39e-01
Transcriptional regulation by small RNAs 60 1.27e-02 -0.186000 6.09e-02
Signaling by KIT in disease 20 1.50e-01 -0.186000 3.29e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 1.50e-01 -0.186000 3.29e-01
MyD88 dependent cascade initiated on endosome 101 1.26e-03 -0.186000 1.07e-02
Deposition of new CENPA-containing nucleosomes at the centromere 39 4.50e-02 -0.186000 1.50e-01
Nucleosome assembly 39 4.50e-02 -0.186000 1.50e-01
Regulation of TP53 Expression and Degradation 37 5.18e-02 -0.185000 1.66e-01
Defects in cobalamin (B12) metabolism 13 2.50e-01 0.184000 4.45e-01
SARS-CoV-2 modulates autophagy 11 2.90e-01 -0.184000 4.81e-01
Degradation of the extracellular matrix 90 2.51e-03 0.184000 1.78e-02
Caspase activation via Death Receptors in the presence of ligand 16 2.04e-01 -0.184000 3.98e-01
Glycerophospholipid biosynthesis 108 9.91e-04 -0.184000 9.12e-03
Methylation 13 2.52e-01 0.183000 4.47e-01
NCAM signaling for neurite out-growth 49 2.63e-02 0.183000 1.04e-01
Ovarian tumor domain proteases 36 5.75e-02 -0.183000 1.78e-01
Potential therapeutics for SARS 101 1.50e-03 -0.183000 1.23e-02
Packaging Of Telomere Ends 19 1.68e-01 -0.183000 3.54e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.05e-03 -0.183000 9.22e-03
Toll Like Receptor 2 (TLR2) Cascade 108 1.05e-03 -0.183000 9.22e-03
Toll Like Receptor TLR1:TLR2 Cascade 108 1.05e-03 -0.183000 9.22e-03
Toll Like Receptor TLR6:TLR2 Cascade 108 1.05e-03 -0.183000 9.22e-03
Regulation of RUNX1 Expression and Activity 18 1.80e-01 -0.183000 3.69e-01
Neutrophil degranulation 457 2.83e-11 -0.182000 1.10e-09
PI3K Cascade 33 7.10e-02 -0.182000 2.08e-01
Resolution of Sister Chromatid Cohesion 105 1.31e-03 -0.182000 1.10e-02
Cleavage of the damaged purine 23 1.32e-01 -0.181000 3.02e-01
Depurination 23 1.32e-01 -0.181000 3.02e-01
Recognition and association of DNA glycosylase with site containing an affected purine 23 1.32e-01 -0.181000 3.02e-01
HCMV Late Events 69 9.16e-03 -0.181000 4.94e-02
Glucose metabolism 84 4.12e-03 -0.181000 2.66e-02
Gap junction degradation 10 3.21e-01 0.181000 5.14e-01
Termination of translesion DNA synthesis 31 8.31e-02 -0.180000 2.28e-01
Mitotic G1 phase and G1/S transition 148 1.61e-04 -0.180000 2.08e-03
Postmitotic nuclear pore complex (NPC) reformation 27 1.06e-01 -0.180000 2.65e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 24 1.29e-01 0.179000 2.98e-01
cGMP effects 16 2.15e-01 0.179000 4.09e-01
SUMOylation of DNA damage response and repair proteins 77 6.66e-03 -0.179000 3.87e-02
MyD88 cascade initiated on plasma membrane 95 2.60e-03 -0.179000 1.81e-02
Toll Like Receptor 10 (TLR10) Cascade 95 2.60e-03 -0.179000 1.81e-02
Toll Like Receptor 5 (TLR5) Cascade 95 2.60e-03 -0.179000 1.81e-02
Signaling by BRAF and RAF1 fusions 58 1.85e-02 -0.179000 7.96e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 6.75e-02 -0.179000 2.02e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 2.07e-03 -0.178000 1.58e-02
mRNA Splicing 189 2.40e-05 -0.178000 4.16e-04
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 6.22e-02 -0.177000 1.89e-01
Arachidonic acid metabolism 45 3.98e-02 -0.177000 1.41e-01
Acyl chain remodelling of PS 17 2.06e-01 0.177000 3.98e-01
Processing of Capped Intronless Pre-mRNA 29 9.91e-02 -0.177000 2.53e-01
Synthesis of PIPs at the Golgi membrane 15 2.36e-01 -0.177000 4.27e-01
Estrogen-dependent gene expression 100 2.25e-03 -0.177000 1.65e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 102 2.14e-03 -0.176000 1.60e-02
Cell Cycle 615 1.10e-13 -0.176000 5.81e-12
DCC mediated attractive signaling 13 2.72e-01 0.176000 4.62e-01
Initial triggering of complement 24 1.38e-01 -0.175000 3.13e-01
COPI-mediated anterograde transport 81 6.52e-03 0.175000 3.82e-02
Metabolism of Angiotensinogen to Angiotensins 16 2.27e-01 0.175000 4.18e-01
SARS-CoV-1 activates/modulates innate immune responses 41 5.33e-02 -0.174000 1.68e-01
HDACs deacetylate histones 45 4.31e-02 -0.174000 1.49e-01
Signaling by FLT3 fusion proteins 19 1.89e-01 -0.174000 3.83e-01
Negative regulation of FLT3 15 2.43e-01 -0.174000 4.36e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 3.41e-01 0.174000 5.35e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.18e-01 -0.174000 2.82e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 42 5.16e-02 -0.174000 1.65e-01
Toll Like Receptor 9 (TLR9) Cascade 105 2.13e-03 -0.174000 1.60e-02
Signaling by NODAL 13 2.79e-01 -0.174000 4.68e-01
Mitotic Telophase/Cytokinesis 13 2.79e-01 -0.174000 4.68e-01
Glycolysis 67 1.42e-02 -0.173000 6.59e-02
Downregulation of ERBB2 signaling 28 1.13e-01 0.173000 2.74e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 14 2.62e-01 0.173000 4.51e-01
ER Quality Control Compartment (ERQC) 21 1.70e-01 -0.173000 3.58e-01
RHO GTPases Activate Formins 119 1.13e-03 -0.173000 9.77e-03
Class B/2 (Secretin family receptors) 67 1.45e-02 0.173000 6.70e-02
Base Excision Repair 58 2.29e-02 -0.173000 9.28e-02
G-protein beta:gamma signalling 28 1.14e-01 -0.172000 2.75e-01
Toll Like Receptor 4 (TLR4) Cascade 137 5.18e-04 -0.172000 5.41e-03
HDR through Homologous Recombination (HRR) 67 1.50e-02 -0.172000 6.84e-02
COPII-mediated vesicle transport 66 1.61e-02 0.171000 7.17e-02
Diseases of DNA repair 51 3.45e-02 -0.171000 1.27e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 1.97e-01 -0.171000 3.91e-01
SLC transporter disorders 72 1.26e-02 -0.170000 6.07e-02
Regulation of TP53 Degradation 36 7.76e-02 -0.170000 2.19e-01
Hedgehog ‘on’ state 83 7.69e-03 0.169000 4.30e-02
Phospholipid metabolism 185 7.70e-05 -0.169000 1.12e-03
Xenobiotics 12 3.13e-01 -0.168000 5.05e-01
Pre-NOTCH Expression and Processing 62 2.21e-02 -0.168000 9.12e-02
Nuclear Envelope (NE) Reassembly 68 1.67e-02 -0.168000 7.39e-02
Signal transduction by L1 21 1.84e-01 -0.167000 3.76e-01
Toll-like Receptor Cascades 159 2.77e-04 -0.167000 3.06e-03
Insulin receptor signalling cascade 42 6.23e-02 -0.166000 1.89e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 2.65e-01 -0.166000 4.52e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 2.65e-01 -0.166000 4.52e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 2.65e-01 -0.166000 4.52e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 2.65e-01 -0.166000 4.52e-01
Norepinephrine Neurotransmitter Release Cycle 15 2.65e-01 -0.166000 4.52e-01
Signaling by CTNNB1 phospho-site mutants 15 2.65e-01 -0.166000 4.52e-01
Signaling by GSK3beta mutants 15 2.65e-01 -0.166000 4.52e-01
Factors involved in megakaryocyte development and platelet production 115 2.10e-03 -0.166000 1.60e-02
Regulation of TP53 Activity through Phosphorylation 89 7.08e-03 -0.165000 4.01e-02
Signaling by NTRK3 (TRKC) 16 2.53e-01 0.165000 4.48e-01
Inositol phosphate metabolism 45 5.59e-02 -0.165000 1.75e-01
Signaling by ALK 25 1.55e-01 -0.164000 3.34e-01
Resolution of Abasic Sites (AP sites) 38 8.02e-02 -0.164000 2.23e-01
GAB1 signalosome 16 2.57e-01 -0.164000 4.48e-01
RHOH GTPase cycle 34 9.87e-02 -0.164000 2.52e-01
EPH-ephrin mediated repulsion of cells 44 6.07e-02 0.163000 1.86e-01
Transcriptional regulation by RUNX2 116 2.41e-03 0.163000 1.74e-02
Removal of the Flap Intermediate from the C-strand 17 2.45e-01 -0.163000 4.38e-01
Erythrocytes take up carbon dioxide and release oxygen 12 3.30e-01 -0.163000 5.22e-01
O2/CO2 exchange in erythrocytes 12 3.30e-01 -0.163000 5.22e-01
GABA receptor activation 41 7.24e-02 0.162000 2.11e-01
Regulation of TP53 Activity through Methylation 19 2.22e-01 -0.162000 4.14e-01
IRS-mediated signalling 37 8.95e-02 -0.161000 2.38e-01
MET activates RAS signaling 11 3.56e-01 -0.161000 5.51e-01
Toll Like Receptor 3 (TLR3) Cascade 103 4.88e-03 -0.161000 3.03e-02
Regulation of innate immune responses to cytosolic DNA 14 2.98e-01 -0.161000 4.90e-01
Negative regulation of MET activity 20 2.14e-01 -0.160000 4.09e-01
Negative regulators of DDX58/IFIH1 signaling 35 1.01e-01 -0.160000 2.57e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 2.69e-02 0.160000 1.05e-01
FGFR1 mutant receptor activation 25 1.68e-01 -0.159000 3.54e-01
Calnexin/calreticulin cycle 26 1.60e-01 -0.159000 3.42e-01
ER to Golgi Anterograde Transport 132 1.59e-03 0.159000 1.29e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 2.42e-01 -0.159000 4.35e-01
Inactivation, recovery and regulation of the phototransduction cascade 21 2.07e-01 0.159000 3.98e-01
Signaling by PDGFR in disease 20 2.19e-01 -0.159000 4.13e-01
G1/S Transition 130 1.82e-03 -0.158000 1.44e-02
Presynaptic phase of homologous DNA pairing and strand exchange 40 8.30e-02 -0.158000 2.28e-01
Tight junction interactions 17 2.58e-01 0.158000 4.49e-01
Leading Strand Synthesis 14 3.06e-01 -0.158000 4.99e-01
Polymerase switching 14 3.06e-01 -0.158000 4.99e-01
Transcriptional regulation by RUNX1 183 2.32e-04 -0.158000 2.67e-03
Serotonin Neurotransmitter Release Cycle 16 2.76e-01 -0.157000 4.65e-01
Mitotic Spindle Checkpoint 109 4.60e-03 -0.157000 2.90e-02
CD209 (DC-SIGN) signaling 20 2.24e-01 -0.157000 4.17e-01
Homologous DNA Pairing and Strand Exchange 43 7.50e-02 -0.157000 2.15e-01
Retrograde neurotrophin signalling 14 3.10e-01 -0.157000 5.03e-01
Rap1 signalling 15 2.94e-01 -0.157000 4.85e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 3.69e-01 -0.156000 5.62e-01
VEGFR2 mediated cell proliferation 19 2.38e-01 0.156000 4.30e-01
Impaired BRCA2 binding to RAD51 35 1.10e-01 -0.156000 2.70e-01
Gene Silencing by RNA 85 1.29e-02 -0.156000 6.14e-02
Attenuation phase 22 2.05e-01 0.156000 3.98e-01
Incretin synthesis, secretion, and inactivation 14 3.14e-01 0.156000 5.05e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 3.14e-01 0.156000 5.05e-01
FLT3 signaling in disease 28 1.55e-01 -0.155000 3.34e-01
Nuclear Receptor transcription pathway 40 8.90e-02 -0.155000 2.37e-01
DNA Damage Bypass 46 6.82e-02 -0.155000 2.03e-01
Chromosome Maintenance 102 6.74e-03 -0.155000 3.88e-02
RNA Polymerase I Promoter Escape 44 7.48e-02 0.155000 2.15e-01
RHO GTPases Activate WASPs and WAVEs 36 1.07e-01 -0.155000 2.65e-01
Processing of DNA double-strand break ends 68 2.69e-02 -0.155000 1.05e-01
Signaling by CSF3 (G-CSF) 29 1.48e-01 -0.155000 3.27e-01
DNA Repair 293 5.08e-06 -0.155000 1.03e-04
Viral Messenger RNA Synthesis 44 7.57e-02 -0.155000 2.15e-01
Glutamate and glutamine metabolism 11 3.76e-01 0.154000 5.70e-01
SIRT1 negatively regulates rRNA expression 21 2.22e-01 -0.154000 4.14e-01
Impaired BRCA2 binding to PALB2 24 1.92e-01 -0.154000 3.86e-01
Cell junction organization 67 3.01e-02 0.153000 1.14e-01
Translesion Synthesis by POLH 18 2.61e-01 -0.153000 4.51e-01
Plasma lipoprotein remodeling 21 2.26e-01 -0.153000 4.18e-01
RHO GTPase Effectors 249 3.43e-05 -0.153000 5.48e-04
M Phase 357 7.66e-07 -0.153000 1.91e-05
Nicotinamide salvaging 16 2.92e-01 -0.152000 4.84e-01
O-linked glycosylation 90 1.27e-02 0.152000 6.09e-02
Negative regulation of MAPK pathway 42 8.84e-02 -0.152000 2.37e-01
Netrin-1 signaling 44 8.15e-02 0.152000 2.26e-01
IL-6-type cytokine receptor ligand interactions 15 3.09e-01 0.152000 5.02e-01
Regulated proteolysis of p75NTR 11 3.84e-01 -0.152000 5.76e-01
Signaling by FGFR2 in disease 34 1.28e-01 0.151000 2.96e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 2.56e-01 -0.150000 4.48e-01
Regulation of PLK1 Activity at G2/M Transition 86 1.59e-02 -0.150000 7.17e-02
Assembly and cell surface presentation of NMDA receptors 25 1.93e-01 0.150000 3.86e-01
Intrinsic Pathway for Apoptosis 54 5.61e-02 -0.150000 1.75e-01
Telomere Maintenance 77 2.27e-02 -0.150000 9.28e-02
Effects of PIP2 hydrolysis 24 2.06e-01 -0.149000 3.98e-01
Cyclin D associated events in G1 47 7.74e-02 -0.149000 2.18e-01
G1 Phase 47 7.74e-02 -0.149000 2.18e-01
Ribavirin ADME 10 4.18e-01 0.148000 6.08e-01
Lewis blood group biosynthesis 12 3.75e-01 0.148000 5.69e-01
FCERI mediated Ca+2 mobilization 33 1.42e-01 -0.148000 3.19e-01
Cargo recognition for clathrin-mediated endocytosis 97 1.21e-02 -0.148000 5.90e-02
ADP signalling through P2Y purinoceptor 12 17 2.93e-01 0.147000 4.84e-01
TBC/RABGAPs 45 8.75e-02 -0.147000 2.37e-01
Ras activation upon Ca2+ influx through NMDA receptor 20 2.55e-01 0.147000 4.48e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.04e-01 0.147000 3.98e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.98e-01 -0.146000 4.90e-01
Ubiquitin-dependent degradation of Cyclin D 50 7.51e-02 0.146000 2.15e-01
Vif-mediated degradation of APOBEC3G 52 6.95e-02 0.146000 2.06e-01
Transcriptional Regulation by TP53 347 3.49e-06 -0.145000 7.35e-05
Transferrin endocytosis and recycling 28 1.84e-01 0.145000 3.75e-01
Role of phospholipids in phagocytosis 34 1.45e-01 -0.145000 3.22e-01
RHO GTPases activate KTN1 11 4.08e-01 -0.144000 5.99e-01
RND2 GTPase cycle 39 1.19e-01 -0.144000 2.84e-01
Regulation of Apoptosis 51 7.51e-02 0.144000 2.15e-01
Carnitine metabolism 12 3.88e-01 -0.144000 5.80e-01
Acetylcholine regulates insulin secretion 10 4.31e-01 -0.144000 6.17e-01
Regulation of RUNX2 expression and activity 70 3.78e-02 0.144000 1.36e-01
SUMOylation of transcription cofactors 44 9.99e-02 -0.143000 2.54e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 7.12e-02 0.143000 2.08e-01
Regulation of RAS by GAPs 66 4.42e-02 0.143000 1.50e-01
Signaling by ERBB2 TMD/JMD mutants 21 2.56e-01 0.143000 4.48e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 2.15e-01 -0.143000 4.09e-01
Tie2 Signaling 17 3.10e-01 -0.142000 5.03e-01
NGF-stimulated transcription 34 1.52e-01 -0.142000 3.30e-01
MyD88-independent TLR4 cascade 107 1.13e-02 -0.142000 5.68e-02
TRIF(TICAM1)-mediated TLR4 signaling 107 1.13e-02 -0.142000 5.68e-02
FCGR3A-mediated phagocytosis 68 4.42e-02 -0.141000 1.50e-01
Leishmania phagocytosis 68 4.42e-02 -0.141000 1.50e-01
Parasite infection 68 4.42e-02 -0.141000 1.50e-01
ERBB2 Regulates Cell Motility 14 3.61e-01 0.141000 5.56e-01
Activation of GABAB receptors 33 1.61e-01 0.141000 3.44e-01
GABA B receptor activation 33 1.61e-01 0.141000 3.44e-01
Regulation of TP53 Activity through Association with Co-factors 12 3.98e-01 -0.141000 5.91e-01
Interleukin-10 signaling 37 1.39e-01 -0.141000 3.13e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 52 8.02e-02 -0.140000 2.23e-01
Lysine catabolism 11 4.21e-01 -0.140000 6.10e-01
RHOA GTPase cycle 144 3.73e-03 -0.140000 2.45e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.36e-01 -0.140000 4.27e-01
Lysosphingolipid and LPA receptors 12 4.02e-01 0.140000 5.95e-01
TICAM1-dependent activation of IRF3/IRF7 12 4.03e-01 -0.139000 5.95e-01
RHO GTPases activate PKNs 45 1.07e-01 -0.139000 2.65e-01
Signaling by ERBB2 in Cancer 25 2.31e-01 0.138000 4.22e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 2.84e-01 -0.138000 4.74e-01
FCGR activation 21 2.72e-01 -0.138000 4.62e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.24e-01 -0.138000 5.16e-01
COPI-dependent Golgi-to-ER retrograde traffic 79 3.46e-02 0.138000 1.27e-01
Sensory Perception 168 2.14e-03 0.137000 1.60e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 33 1.73e-01 0.137000 3.61e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 2.10e-01 -0.137000 4.02e-01
Recycling pathway of L1 27 2.18e-01 -0.137000 4.12e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 4.55e-01 -0.137000 6.41e-01
DNA Double Strand Break Response 49 9.85e-02 -0.136000 2.52e-01
Nuclear Events (kinase and transcription factor activation) 56 7.74e-02 -0.136000 2.18e-01
RAC1 GTPase cycle 178 1.71e-03 -0.136000 1.37e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.31e-01 -0.136000 3.02e-01
Diseases of DNA Double-Strand Break Repair 41 1.31e-01 -0.136000 3.02e-01
G2/M DNA damage checkpoint 64 5.98e-02 -0.136000 1.84e-01
RNA Polymerase III Transcription Termination 23 2.59e-01 0.136000 4.49e-01
Chemokine receptors bind chemokines 38 1.47e-01 -0.136000 3.26e-01
Heparan sulfate/heparin (HS-GAG) metabolism 42 1.27e-01 0.136000 2.96e-01
HDR through Single Strand Annealing (SSA) 37 1.53e-01 -0.136000 3.33e-01
Drug ADME 61 6.70e-02 -0.136000 2.01e-01
SLBP independent Processing of Histone Pre-mRNAs 10 4.58e-01 0.136000 6.44e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 4.37e-01 0.135000 6.22e-01
RHOJ GTPase cycle 54 8.65e-02 -0.135000 2.35e-01
MyD88 deficiency (TLR2/4) 14 3.84e-01 -0.134000 5.76e-01
PI Metabolism 78 4.02e-02 -0.134000 1.42e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 1.04e-01 0.134000 2.61e-01
Immune System 1728 4.17e-20 -0.134000 3.61e-18
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 9.42e-02 0.134000 2.44e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.46e-01 -0.134000 4.40e-01
Signaling by FGFR1 in disease 32 1.91e-01 -0.134000 3.85e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 2.30e-01 0.133000 4.22e-01
Interleukin-17 signaling 67 6.01e-02 -0.133000 1.85e-01
Cell Cycle Checkpoints 256 2.70e-04 -0.132000 3.01e-03
SHC-mediated cascade:FGFR3 12 4.29e-01 0.132000 6.16e-01
Processing and activation of SUMO 10 4.72e-01 -0.131000 6.54e-01
Innate Immune System 923 1.73e-11 -0.131000 6.89e-10
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 25 2.56e-01 -0.131000 4.48e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 25 2.56e-01 -0.131000 4.48e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 2.56e-01 -0.131000 4.48e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 2.56e-01 -0.131000 4.48e-01
Phase I - Functionalization of compounds 74 5.23e-02 -0.131000 1.66e-01
SHC-mediated cascade:FGFR2 14 3.99e-01 0.130000 5.91e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.19e-01 0.130000 2.84e-01
The NLRP3 inflammasome 16 3.69e-01 -0.130000 5.62e-01
Glycogen synthesis 13 4.20e-01 0.129000 6.10e-01
IRAK1 recruits IKK complex 10 4.80e-01 -0.129000 6.59e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 4.80e-01 -0.129000 6.59e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 48 1.22e-01 -0.129000 2.87e-01
Hedgehog ‘off’ state 95 3.02e-02 0.129000 1.14e-01
Uptake and actions of bacterial toxins 26 2.56e-01 -0.129000 4.48e-01
Degradation of GLI2 by the proteasome 57 9.36e-02 0.128000 2.43e-01
tRNA processing in the nucleus 59 8.86e-02 -0.128000 2.37e-01
Nuclear signaling by ERBB4 30 2.24e-01 -0.128000 4.17e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.68e-01 -0.128000 4.56e-01
MAP kinase activation 63 7.94e-02 -0.128000 2.22e-01
G beta:gamma signalling through BTK 14 4.08e-01 0.128000 5.99e-01
Vpu mediated degradation of CD4 50 1.18e-01 0.128000 2.82e-01
Pre-NOTCH Processing in Golgi 18 3.49e-01 0.127000 5.46e-01
Interaction between L1 and Ankyrins 25 2.70e-01 0.127000 4.60e-01
Activation of BAD and translocation to mitochondria 14 4.10e-01 -0.127000 6.00e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 3.78e-01 -0.127000 5.71e-01
Deubiquitination 239 7.14e-04 -0.127000 7.16e-03
Inactivation of CSF3 (G-CSF) signaling 24 2.82e-01 -0.127000 4.72e-01
Cytokine Signaling in Immune system 616 8.26e-08 -0.127000 2.43e-06
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.38e-01 0.126000 3.13e-01
Infection with Mycobacterium tuberculosis 27 2.56e-01 -0.126000 4.48e-01
Assembly of active LPL and LIPC lipase complexes 13 4.32e-01 -0.126000 6.17e-01
SARS-CoV-1-host interactions 95 3.43e-02 0.126000 1.27e-01
GLI3 is processed to GLI3R by the proteasome 57 1.02e-01 0.125000 2.59e-01
Potassium Channels 61 9.17e-02 0.125000 2.41e-01
Nonhomologous End-Joining (NHEJ) 39 1.77e-01 -0.125000 3.67e-01
Hh mutants abrogate ligand secretion 56 1.06e-01 0.125000 2.65e-01
Interconversion of nucleotide di- and triphosphates 28 2.54e-01 0.125000 4.48e-01
DAP12 interactions 35 2.03e-01 -0.124000 3.98e-01
Mitophagy 28 2.58e-01 0.124000 4.49e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.60e-01 0.123000 4.50e-01
HS-GAG degradation 19 3.53e-01 0.123000 5.49e-01
Hedgehog ligand biogenesis 61 9.68e-02 0.123000 2.49e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.80e-01 -0.123000 5.73e-01
Fcgamma receptor (FCGR) dependent phagocytosis 95 3.90e-02 -0.123000 1.39e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 4.27e-01 -0.123000 6.15e-01
Degradation of AXIN 53 1.23e-01 0.122000 2.88e-01
RAC3 GTPase cycle 89 4.68e-02 -0.122000 1.54e-01
TP53 Regulates Transcription of Cell Death Genes 42 1.72e-01 -0.122000 3.60e-01
Heme signaling 45 1.58e-01 -0.122000 3.39e-01
Formation of the Early Elongation Complex 33 2.27e-01 0.122000 4.18e-01
Formation of the HIV-1 Early Elongation Complex 33 2.27e-01 0.122000 4.18e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.01e-01 -0.121000 2.57e-01
HSF1-dependent transactivation 32 2.35e-01 0.121000 4.26e-01
RAC2 GTPase cycle 87 5.06e-02 -0.121000 1.64e-01
Metabolism of non-coding RNA 53 1.28e-01 -0.121000 2.96e-01
snRNP Assembly 53 1.28e-01 -0.121000 2.96e-01
Iron uptake and transport 55 1.21e-01 0.121000 2.86e-01
LDL clearance 18 3.75e-01 -0.121000 5.69e-01
Transport to the Golgi and subsequent modification 157 9.09e-03 0.121000 4.92e-02
ERK/MAPK targets 22 3.27e-01 -0.121000 5.20e-01
Synaptic adhesion-like molecules 20 3.51e-01 0.120000 5.47e-01
Epigenetic regulation of gene expression 100 3.75e-02 -0.120000 1.36e-01
Cell surface interactions at the vascular wall 128 1.87e-02 -0.120000 7.96e-02
Free fatty acids regulate insulin secretion 10 5.11e-01 -0.120000 6.87e-01
Metabolism of polyamines 56 1.21e-01 0.120000 2.86e-01
Signaling by ERBB2 48 1.51e-01 0.120000 3.29e-01
Regulation of actin dynamics for phagocytic cup formation 70 8.40e-02 -0.119000 2.30e-01
Surfactant metabolism 18 3.81e-01 -0.119000 5.73e-01
Cleavage of the damaged pyrimidine 28 2.75e-01 -0.119000 4.64e-01
Depyrimidination 28 2.75e-01 -0.119000 4.64e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 28 2.75e-01 -0.119000 4.64e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 3.03e-01 0.119000 4.96e-01
Purine catabolism 13 4.59e-01 0.119000 6.44e-01
Suppression of phagosomal maturation 13 4.60e-01 0.118000 6.44e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 4.28e-01 -0.118000 6.15e-01
Protein-protein interactions at synapses 74 7.90e-02 0.118000 2.21e-01
Diseases of metabolism 207 3.52e-03 0.118000 2.35e-02
Synthesis of PA 33 2.43e-01 -0.117000 4.36e-01
CTLA4 inhibitory signaling 20 3.64e-01 -0.117000 5.59e-01
Leishmania infection 160 1.15e-02 -0.116000 5.76e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.45e-01 0.116000 3.22e-01
Dectin-2 family 16 4.23e-01 -0.116000 6.13e-01
Acetylcholine Neurotransmitter Release Cycle 13 4.71e-01 -0.115000 6.54e-01
RNA Polymerase III Abortive And Retractive Initiation 41 2.02e-01 0.115000 3.97e-01
RNA Polymerase III Transcription 41 2.02e-01 0.115000 3.97e-01
Fatty acid metabolism 155 1.37e-02 -0.115000 6.42e-02
Adrenaline,noradrenaline inhibits insulin secretion 24 3.31e-01 0.115000 5.25e-01
Clathrin-mediated endocytosis 135 2.17e-02 -0.115000 8.97e-02
Oncogenic MAPK signaling 74 8.95e-02 -0.114000 2.38e-01
Signaling by Hedgehog 130 2.47e-02 0.114000 9.84e-02
SHC1 events in ERBB2 signaling 21 3.65e-01 0.114000 5.60e-01
Signaling by ERBB2 KD Mutants 24 3.34e-01 0.114000 5.28e-01
Downregulation of TGF-beta receptor signaling 26 3.15e-01 0.114000 5.05e-01
Aggrephagy 21 3.66e-01 0.114000 5.60e-01
Negative regulation of the PI3K/AKT network 97 5.28e-02 -0.114000 1.67e-01
Activation of HOX genes during differentiation 71 9.77e-02 -0.114000 2.51e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 71 9.77e-02 -0.114000 2.51e-01
Cellular response to hypoxia 72 9.58e-02 0.114000 2.48e-01
Degradation of GLI1 by the proteasome 57 1.39e-01 0.113000 3.13e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.76e-01 -0.113000 4.64e-01
RNA Polymerase III Chain Elongation 18 4.06e-01 0.113000 5.97e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 4.64e-01 0.113000 6.49e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 4.21e-01 0.113000 6.10e-01
DNA Replication 138 2.24e-02 -0.113000 9.19e-02
RA biosynthesis pathway 19 3.96e-01 0.113000 5.88e-01
G2/M Checkpoints 135 2.45e-02 -0.112000 9.84e-02
Amyloid fiber formation 47 1.86e-01 -0.112000 3.78e-01
Synthesis of PIPs at the plasma membrane 50 1.73e-01 -0.112000 3.60e-01
p38MAPK events 13 4.86e-01 0.112000 6.64e-01
RHOQ GTPase cycle 58 1.42e-01 -0.111000 3.19e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 76 9.42e-02 -0.111000 2.44e-01
Regulation of ornithine decarboxylase (ODC) 48 1.84e-01 0.111000 3.75e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 4.72e-01 0.111000 6.55e-01
Signaling by NTRK1 (TRKA) 109 4.56e-02 -0.111000 1.51e-01
Basigin interactions 23 3.58e-01 -0.111000 5.52e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.26e-01 0.111000 2.94e-01
RHOB GTPase cycle 66 1.21e-01 -0.110000 2.86e-01
S Phase 161 1.61e-02 -0.110000 7.17e-02
Fatty acyl-CoA biosynthesis 35 2.61e-01 -0.110000 4.51e-01
Signaling by FGFR3 in disease 16 4.47e-01 0.110000 6.32e-01
Adaptive Immune System 679 1.22e-06 -0.110000 2.89e-05
Amino acids regulate mTORC1 50 1.80e-01 0.110000 3.69e-01
MET activates RAP1 and RAC1 11 5.32e-01 -0.109000 7.00e-01
Response of Mtb to phagocytosis 23 3.66e-01 -0.109000 5.60e-01
HIV Transcription Initiation 45 2.07e-01 0.109000 3.98e-01
RNA Polymerase II HIV Promoter Escape 45 2.07e-01 0.109000 3.98e-01
RNA Polymerase II Promoter Escape 45 2.07e-01 0.109000 3.98e-01
RNA Polymerase II Transcription Initiation 45 2.07e-01 0.109000 3.98e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 2.07e-01 0.109000 3.98e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 2.07e-01 0.109000 3.98e-01
Nephrin family interactions 20 4.01e-01 0.108000 5.94e-01
The phototransduction cascade 22 3.81e-01 0.108000 5.73e-01
Mitotic G2-G2/M phases 182 1.27e-02 -0.107000 6.09e-02
Hh mutants are degraded by ERAD 53 1.77e-01 0.107000 3.67e-01
Metabolic disorders of biological oxidation enzymes 23 3.74e-01 -0.107000 5.68e-01
Signaling by Interleukins 406 2.24e-04 -0.107000 2.64e-03
Presynaptic function of Kainate receptors 17 4.46e-01 0.107000 6.32e-01
Transcriptional Regulation by NPAS4 31 3.04e-01 -0.107000 4.97e-01
TGF-beta receptor signaling activates SMADs 44 2.22e-01 0.106000 4.14e-01
CDC42 GTPase cycle 150 2.46e-02 -0.106000 9.84e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 1.94e-01 0.106000 3.86e-01
p53-Independent DNA Damage Response 50 1.94e-01 0.106000 3.86e-01
p53-Independent G1/S DNA damage checkpoint 50 1.94e-01 0.106000 3.86e-01
FOXO-mediated transcription of cell cycle genes 15 4.76e-01 -0.106000 6.55e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 2.41e-01 0.106000 4.34e-01
MET receptor recycling 10 5.63e-01 -0.106000 7.25e-01
Anchoring of the basal body to the plasma membrane 96 7.43e-02 -0.105000 2.14e-01
APC/C:Cdc20 mediated degradation of Securin 66 1.39e-01 0.105000 3.13e-01
DNA Replication Pre-Initiation 112 5.42e-02 -0.105000 1.71e-01
Metabolism of lipids 634 6.84e-06 -0.105000 1.34e-04
Negative regulation of NOTCH4 signaling 54 1.83e-01 0.105000 3.74e-01
Vitamin D (calciferol) metabolism 10 5.66e-01 -0.105000 7.28e-01
Cell-Cell communication 98 7.55e-02 0.104000 2.15e-01
Translesion synthesis by POLI 17 4.59e-01 -0.104000 6.44e-01
HIV elongation arrest and recovery 32 3.11e-01 -0.103000 5.03e-01
Pausing and recovery of HIV elongation 32 3.11e-01 -0.103000 5.03e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 1.74e-01 0.103000 3.61e-01
Ephrin signaling 19 4.36e-01 0.103000 6.21e-01
Common Pathway of Fibrin Clot Formation 13 5.19e-01 0.103000 6.92e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 4.36e-01 -0.103000 6.21e-01
RHOF GTPase cycle 40 2.59e-01 -0.103000 4.49e-01
Signaling by Nuclear Receptors 228 8.06e-03 -0.102000 4.45e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 5.78e-01 -0.102000 7.38e-01
SHC1 events in EGFR signaling 13 5.27e-01 -0.101000 6.98e-01
Retrograde transport at the Trans-Golgi-Network 49 2.22e-01 -0.101000 4.14e-01
Cell-extracellular matrix interactions 16 4.85e-01 -0.101000 6.63e-01
RNA Polymerase III Transcription Initiation 36 2.95e-01 0.101000 4.87e-01
NOD1/2 Signaling Pathway 32 3.24e-01 -0.101000 5.16e-01
RHOBTB1 GTPase cycle 23 4.03e-01 0.101000 5.95e-01
KEAP1-NFE2L2 pathway 97 8.80e-02 -0.100000 2.37e-01
Deadenylation-dependent mRNA decay 53 2.07e-01 -0.100000 3.98e-01
Base-Excision Repair, AP Site Formation 30 3.47e-01 -0.099300 5.42e-01
Endogenous sterols 20 4.42e-01 0.099200 6.28e-01
Platelet degranulation 113 6.91e-02 0.099100 2.05e-01
Downregulation of ERBB2:ERBB3 signaling 13 5.37e-01 0.098800 7.05e-01
G2/M Transition 180 2.24e-02 -0.098800 9.19e-02
HS-GAG biosynthesis 23 4.13e-01 0.098600 6.05e-01
NRAGE signals death through JNK 56 2.03e-01 -0.098400 3.98e-01
Senescence-Associated Secretory Phenotype (SASP) 64 1.74e-01 -0.098300 3.61e-01
Attachment and Entry 9694614 15 5.10e-01 0.098300 6.87e-01
Golgi-to-ER retrograde transport 112 7.26e-02 0.098200 2.11e-01
FRS-mediated FGFR2 signaling 16 4.98e-01 0.097900 6.76e-01
SCF-beta-TrCP mediated degradation of Emi1 53 2.18e-01 0.097900 4.12e-01
NIK–>noncanonical NF-kB signaling 57 2.02e-01 0.097800 3.97e-01
Regulation of localization of FOXO transcription factors 11 5.75e-01 -0.097700 7.35e-01
IRAK4 deficiency (TLR2/4) 15 5.12e-01 -0.097700 6.87e-01
PI3K/AKT Signaling in Cancer 90 1.10e-01 -0.097600 2.70e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 627 3.28e-05 -0.097500 5.31e-04
Mitotic Metaphase and Anaphase 224 1.20e-02 -0.097500 5.90e-02
Glucagon-type ligand receptors 22 4.29e-01 0.097400 6.16e-01
Transport of bile salts and organic acids, metal ions and amine compounds 51 2.29e-01 0.097300 4.21e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 5.28e-01 0.097300 6.98e-01
Prostacyclin signalling through prostacyclin receptor 15 5.15e-01 0.097100 6.89e-01
Diseases associated with N-glycosylation of proteins 20 4.53e-01 -0.097000 6.39e-01
Stabilization of p53 54 2.18e-01 0.096900 4.12e-01
Activated NTRK2 signals through FRS2 and FRS3 10 5.96e-01 -0.096800 7.52e-01
Regulation of PTEN stability and activity 67 1.71e-01 0.096800 3.58e-01
HIV Life Cycle 146 4.40e-02 -0.096600 1.50e-01
Uptake and function of anthrax toxins 11 5.79e-01 -0.096600 7.38e-01
Formation of TC-NER Pre-Incision Complex 53 2.25e-01 0.096500 4.17e-01
Advanced glycosylation endproduct receptor signaling 12 5.63e-01 -0.096300 7.25e-01
Mitotic Anaphase 223 1.34e-02 -0.096200 6.30e-02
Transcriptional Regulation by MECP2 56 2.14e-01 -0.096100 4.08e-01
RHO GTPases activate PAKs 21 4.47e-01 -0.095900 6.32e-01
G-protein activation 19 4.70e-01 0.095800 6.54e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 5.82e-01 0.095700 7.41e-01
RET signaling 34 3.34e-01 -0.095700 5.28e-01
SCF(Skp2)-mediated degradation of p27/p21 60 2.00e-01 0.095700 3.96e-01
G beta:gamma signalling through PLC beta 16 5.08e-01 0.095700 6.87e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 1.64e-01 0.095600 3.47e-01
GRB2 events in EGFR signaling 12 5.67e-01 -0.095500 7.28e-01
ESR-mediated signaling 163 3.56e-02 -0.095500 1.30e-01
Listeria monocytogenes entry into host cells 19 4.72e-01 -0.095400 6.54e-01
Degradation of DVL 55 2.22e-01 0.095300 4.14e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 3.85e-01 0.094800 5.78e-01
FRS-mediated FGFR3 signaling 14 5.39e-01 0.094800 7.07e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 90 1.22e-01 -0.094400 2.86e-01
PI3K events in ERBB2 signaling 15 5.27e-01 0.094200 6.98e-01
The activation of arylsulfatases 10 6.06e-01 0.094200 7.61e-01
RAB geranylgeranylation 61 2.04e-01 0.094100 3.98e-01
Response to elevated platelet cytosolic Ca2+ 117 7.90e-02 0.094100 2.21e-01
Activation of kainate receptors upon glutamate binding 25 4.16e-01 0.094000 6.07e-01
Blood group systems biosynthesis 16 5.17e-01 -0.093700 6.91e-01
EGFR downregulation 29 3.84e-01 -0.093400 5.76e-01
Signaling by Rho GTPases 612 8.51e-05 -0.093400 1.20e-03
Dectin-1 mediated noncanonical NF-kB signaling 58 2.19e-01 0.093300 4.13e-01
Death Receptor Signalling 141 5.65e-02 -0.093100 1.76e-01
Integrin cell surface interactions 61 2.10e-01 0.092900 4.02e-01
Formation of Incision Complex in GG-NER 43 2.92e-01 0.092800 4.84e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 5.50e-01 0.092400 7.16e-01
RHOD GTPase cycle 52 2.51e-01 -0.092100 4.46e-01
Cellular hexose transport 16 5.24e-01 -0.092000 6.96e-01
PI-3K cascade:FGFR2 14 5.52e-01 0.091900 7.16e-01
Transcriptional activation of mitochondrial biogenesis 51 2.57e-01 -0.091800 4.48e-01
Developmental Biology 790 1.32e-05 0.091600 2.44e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 1.81e-01 0.091300 3.70e-01
rRNA modification in the nucleus and cytosol 59 2.30e-01 0.090500 4.21e-01
PIWI-interacting RNA (piRNA) biogenesis 21 4.74e-01 0.090200 6.55e-01
Cholesterol biosynthesis 27 4.17e-01 0.090200 6.08e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 4.76e-01 -0.089900 6.55e-01
Neurodegenerative Diseases 21 4.76e-01 -0.089900 6.55e-01
Regulation of RUNX3 expression and activity 55 2.51e-01 0.089600 4.46e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 6.28e-01 0.088400 7.79e-01
p75 NTR receptor-mediated signalling 92 1.44e-01 -0.088200 3.21e-01
RHOBTB2 GTPase cycle 23 4.65e-01 0.088000 6.49e-01
Pausing and recovery of Tat-mediated HIV elongation 30 4.04e-01 -0.088000 5.95e-01
Tat-mediated HIV elongation arrest and recovery 30 4.04e-01 -0.088000 5.95e-01
PIP3 activates AKT signaling 252 1.66e-02 -0.087800 7.34e-02
RHOV GTPase cycle 36 3.63e-01 -0.087700 5.58e-01
Regulation of TNFR1 signaling 40 3.38e-01 -0.087500 5.33e-01
PI-3K cascade:FGFR3 12 6.01e-01 0.087200 7.57e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 3.61e-01 0.086900 5.56e-01
Downstream signaling of activated FGFR2 21 4.91e-01 0.086800 6.70e-01
Defective Intrinsic Pathway for Apoptosis 24 4.62e-01 -0.086800 6.46e-01
ADP signalling through P2Y purinoceptor 1 21 4.93e-01 0.086400 6.71e-01
Glycogen breakdown (glycogenolysis) 14 5.78e-01 -0.085900 7.38e-01
Synthesis of DNA 119 1.08e-01 -0.085300 2.67e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 5.55e-01 -0.085300 7.17e-01
RHOC GTPase cycle 71 2.15e-01 -0.085100 4.09e-01
tRNA Aminoacylation 42 3.41e-01 0.085000 5.35e-01
Selective autophagy 58 2.65e-01 0.084700 4.52e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 4.93e-01 0.084400 6.71e-01
Glyoxylate metabolism and glycine degradation 24 4.74e-01 0.084400 6.55e-01
Bile acid and bile salt metabolism 30 4.26e-01 -0.084100 6.14e-01
TNF signaling 49 3.10e-01 -0.083900 5.03e-01
Downstream signaling of activated FGFR3 19 5.29e-01 0.083400 6.98e-01
Metalloprotease DUBs 22 5.01e-01 -0.082800 6.80e-01
Sensory processing of sound by inner hair cells of the cochlea 53 2.98e-01 0.082600 4.90e-01
Peptide hormone metabolism 62 2.62e-01 0.082300 4.52e-01
Formation of tubulin folding intermediates by CCT/TriC 20 5.24e-01 0.082200 6.96e-01
Ub-specific processing proteases 168 6.75e-02 -0.081800 2.02e-01
EPHA-mediated growth cone collapse 15 5.84e-01 0.081700 7.41e-01
Signaling by NTRKs 126 1.14e-01 -0.081600 2.74e-01
RHOBTB GTPase Cycle 35 4.04e-01 0.081600 5.95e-01
Intracellular signaling by second messengers 289 1.77e-02 -0.081200 7.75e-02
PKA activation in glucagon signalling 15 5.87e-01 -0.080900 7.45e-01
Signalling to RAS 20 5.32e-01 0.080800 7.00e-01
Physiological factors 10 6.58e-01 -0.080700 8.00e-01
NRIF signals cell death from the nucleus 16 5.78e-01 0.080400 7.38e-01
RHO GTPases activate CIT 19 5.44e-01 -0.080400 7.11e-01
Transcriptional Regulation by VENTX 39 3.89e-01 -0.079700 5.81e-01
p75NTR recruits signalling complexes 13 6.19e-01 0.079700 7.74e-01
TRP channels 18 5.59e-01 0.079500 7.22e-01
Pexophagy 11 6.48e-01 -0.079400 7.92e-01
Plasma lipoprotein assembly 11 6.49e-01 0.079300 7.92e-01
RAF activation 34 4.24e-01 -0.079300 6.13e-01
Synthesis of PIPs at the late endosome membrane 11 6.49e-01 0.079200 7.92e-01
VLDLR internalisation and degradation 16 5.84e-01 -0.079100 7.41e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 2.41e-01 0.078800 4.34e-01
Downstream signaling events of B Cell Receptor (BCR) 79 2.27e-01 0.078700 4.18e-01
PLC beta mediated events 46 3.57e-01 -0.078500 5.52e-01
Glutathione conjugation 29 4.64e-01 -0.078500 6.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 6.24e-01 0.078400 7.77e-01
IKK complex recruitment mediated by RIP1 23 5.16e-01 0.078200 6.91e-01
Protein localization 156 9.37e-02 0.077800 2.43e-01
Signaling by EGFR 48 3.51e-01 -0.077800 5.47e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 3.57e-01 -0.077600 5.52e-01
Signaling by NOTCH1 72 2.56e-01 -0.077400 4.48e-01
Rab regulation of trafficking 121 1.42e-01 -0.077200 3.19e-01
Deactivation of the beta-catenin transactivating complex 40 3.99e-01 -0.077100 5.91e-01
G-protein mediated events 50 3.46e-01 -0.077000 5.42e-01
Phase 2 - plateau phase 10 6.76e-01 0.076200 8.09e-01
Defective CFTR causes cystic fibrosis 58 3.17e-01 0.076000 5.09e-01
Induction of Cell-Cell Fusion 10 6.78e-01 -0.075900 8.09e-01
Metabolism of proteins 1683 3.10e-07 0.075700 8.47e-06
MAPK6/MAPK4 signaling 84 2.35e-01 0.075100 4.26e-01
Association of TriC/CCT with target proteins during biosynthesis 37 4.31e-01 -0.074900 6.17e-01
Detoxification of Reactive Oxygen Species 33 4.59e-01 0.074500 6.44e-01
Smooth Muscle Contraction 37 4.34e-01 0.074400 6.19e-01
TCF dependent signaling in response to WNT 174 9.22e-02 -0.074100 2.42e-01
Biological oxidations 148 1.21e-01 -0.074000 2.86e-01
Gene expression (Transcription) 1373 5.49e-06 -0.073800 1.09e-04
Recognition of DNA damage by PCNA-containing replication complex 30 4.87e-01 -0.073400 6.64e-01
Activation of NMDA receptors and postsynaptic events 71 2.85e-01 0.073400 4.75e-01
Nucleotide catabolism 26 5.18e-01 -0.073300 6.91e-01
RHOG GTPase cycle 72 2.83e-01 -0.073300 4.73e-01
Diseases associated with glycosylation precursor biosynthesis 15 6.25e-01 0.072900 7.77e-01
Alpha-protein kinase 1 signaling pathway 11 6.76e-01 0.072900 8.09e-01
Asymmetric localization of PCP proteins 62 3.23e-01 0.072700 5.15e-01
tRNA processing 109 1.90e-01 -0.072600 3.85e-01
Disorders of transmembrane transporters 143 1.34e-01 -0.072600 3.05e-01
Formation of apoptosome 11 6.77e-01 -0.072600 8.09e-01
Regulation of the apoptosome activity 11 6.77e-01 -0.072600 8.09e-01
Interleukin-1 family signaling 139 1.42e-01 -0.072200 3.19e-01
Keratinization 28 5.09e-01 0.072100 6.87e-01
DARPP-32 events 23 5.54e-01 -0.071300 7.16e-01
Late Phase of HIV Life Cycle 133 1.57e-01 -0.071200 3.37e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 5.23e-01 0.071100 6.95e-01
Signalling to ERKs 33 4.80e-01 -0.071000 6.59e-01
Neurexins and neuroligins 49 3.90e-01 0.071000 5.82e-01
Signaling by FGFR1 41 4.32e-01 0.071000 6.17e-01
Asparagine N-linked glycosylation 272 4.46e-02 0.070900 1.50e-01
Sensory perception of taste 18 6.03e-01 0.070800 7.58e-01
G alpha (s) signalling events 95 2.35e-01 -0.070600 4.26e-01
Kinesins 40 4.41e-01 -0.070500 6.26e-01
Translesion synthesis by REV1 16 6.26e-01 -0.070500 7.78e-01
Membrane binding and targetting of GAG proteins 14 6.49e-01 -0.070300 7.92e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 6.49e-01 -0.070300 7.92e-01
Synthesis of substrates in N-glycan biosythesis 59 3.51e-01 0.070200 5.47e-01
Establishment of Sister Chromatid Cohesion 11 6.87e-01 -0.070100 8.14e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 6.62e-01 -0.070000 8.01e-01
Fc epsilon receptor (FCERI) signaling 134 1.62e-01 -0.070000 3.45e-01
Signaling by FGFR4 in disease 10 7.02e-01 -0.069900 8.23e-01
Signaling by the B Cell Receptor (BCR) 115 1.96e-01 -0.069800 3.89e-01
Regulation of BACH1 activity 11 6.89e-01 0.069700 8.14e-01
EPH-Ephrin signaling 87 2.62e-01 0.069600 4.51e-01
Ca2+ pathway 57 3.64e-01 0.069600 5.59e-01
Signaling by FGFR2 61 3.48e-01 0.069500 5.44e-01
Cell death signalling via NRAGE, NRIF and NADE 73 3.07e-01 -0.069200 5.00e-01
Separation of Sister Chromatids 168 1.23e-01 -0.069100 2.88e-01
GRB2 events in ERBB2 signaling 15 6.43e-01 0.069100 7.90e-01
RNA Polymerase II Transcription 1242 4.88e-05 -0.069000 7.56e-04
SHC1 events in ERBB4 signaling 13 6.70e-01 0.068300 8.06e-01
Signaling by Activin 14 6.58e-01 -0.068300 8.00e-01
Cytosolic sulfonation of small molecules 19 6.08e-01 0.068000 7.62e-01
Pyruvate metabolism 27 5.43e-01 0.067700 7.10e-01
Post-translational modification: synthesis of GPI-anchored proteins 63 3.54e-01 0.067500 5.49e-01
Amine ligand-binding receptors 11 6.99e-01 0.067300 8.22e-01
Metabolism of water-soluble vitamins and cofactors 114 2.15e-01 -0.067300 4.09e-01
CaM pathway 32 5.11e-01 -0.067100 6.87e-01
Calmodulin induced events 32 5.11e-01 -0.067100 6.87e-01
ROS and RNS production in phagocytes 33 5.05e-01 0.067000 6.84e-01
Mucopolysaccharidoses 11 7.01e-01 0.067000 8.22e-01
Plasma lipoprotein assembly, remodeling, and clearance 59 3.75e-01 -0.066900 5.69e-01
Generic Transcription Pathway 1123 1.90e-04 -0.066500 2.29e-03
Beta-catenin independent WNT signaling 138 1.79e-01 0.066300 3.69e-01
Sensory processing of sound 56 3.91e-01 0.066300 5.82e-01
mTORC1-mediated signalling 24 5.74e-01 0.066300 7.35e-01
Signaling by Retinoic Acid 38 4.81e-01 0.066100 6.59e-01
Interleukin-1 signaling 110 2.32e-01 -0.066000 4.23e-01
CDK-mediated phosphorylation and removal of Cdc6 71 3.38e-01 0.065800 5.33e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 3.25e-01 0.065800 5.17e-01
Mitochondrial biogenesis 87 2.96e-01 0.064800 4.88e-01
Synthesis of very long-chain fatty acyl-CoAs 22 6.00e-01 -0.064700 7.56e-01
Signaling by FGFR 72 3.44e-01 0.064600 5.39e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 4.32e-01 -0.064300 6.17e-01
p53-Dependent G1 DNA Damage Response 63 3.78e-01 0.064300 5.71e-01
p53-Dependent G1/S DNA damage checkpoint 63 3.78e-01 0.064300 5.71e-01
Apoptotic factor-mediated response 20 6.19e-01 0.064200 7.74e-01
Purine salvage 13 6.89e-01 -0.064100 8.14e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 6.78e-01 0.064000 8.09e-01
Spry regulation of FGF signaling 16 6.58e-01 -0.063900 8.00e-01
PTEN Regulation 140 1.95e-01 -0.063500 3.87e-01
Termination of O-glycan biosynthesis 14 6.84e-01 -0.062900 8.14e-01
DAP12 signaling 27 5.72e-01 -0.062800 7.34e-01
Ca-dependent events 34 5.28e-01 -0.062500 6.98e-01
MECP2 regulates neuronal receptors and channels 17 6.56e-01 0.062400 7.99e-01
Anti-inflammatory response favouring Leishmania parasite infection 79 3.39e-01 -0.062300 5.33e-01
Leishmania parasite growth and survival 79 3.39e-01 -0.062300 5.33e-01
Late endosomal microautophagy 31 5.49e-01 0.062200 7.16e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 6.67e-01 -0.062100 8.03e-01
Class I peroxisomal membrane protein import 20 6.32e-01 -0.061900 7.82e-01
Neddylation 226 1.10e-01 0.061700 2.70e-01
Positive epigenetic regulation of rRNA expression 59 4.14e-01 -0.061500 6.05e-01
Early SARS-CoV-2 Infection Events 33 5.42e-01 0.061300 7.10e-01
RHO GTPase cycle 427 3.03e-02 -0.061300 1.15e-01
HSF1 activation 25 5.96e-01 0.061300 7.52e-01
Plasma lipoprotein clearance 34 5.37e-01 -0.061200 7.05e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 7.38e-01 -0.061100 8.51e-01
Neuronal System 281 8.11e-02 0.060600 2.25e-01
Dopamine Neurotransmitter Release Cycle 21 6.33e-01 -0.060200 7.82e-01
Post NMDA receptor activation events 59 4.25e-01 0.060000 6.14e-01
Sensory processing of sound by outer hair cells of the cochlea 40 5.12e-01 0.059900 6.87e-01
Hemostasis 519 2.00e-02 -0.059800 8.41e-02
Intrinsic Pathway of Fibrin Clot Formation 15 6.88e-01 -0.059800 8.14e-01
Signal amplification 28 5.86e-01 0.059500 7.43e-01
Regulation of HSF1-mediated heat shock response 78 3.68e-01 -0.059000 5.60e-01
Interleukin-4 and Interleukin-13 signaling 98 3.13e-01 -0.059000 5.05e-01
SARS-CoV Infections 387 4.70e-02 -0.059000 1.54e-01
Insulin processing 24 6.20e-01 0.058400 7.74e-01
NF-kB is activated and signals survival 13 7.19e-01 -0.057700 8.36e-01
Diseases of carbohydrate metabolism 29 5.91e-01 -0.057600 7.48e-01
G beta:gamma signalling through PI3Kgamma 21 6.51e-01 -0.057100 7.93e-01
Late SARS-CoV-2 Infection Events 67 4.20e-01 -0.057000 6.10e-01
Downstream signal transduction 28 6.02e-01 -0.056900 7.58e-01
RNA Polymerase I Transcription Initiation 47 5.02e-01 0.056600 6.80e-01
Metabolism of nucleotides 85 3.67e-01 -0.056600 5.60e-01
Constitutive Signaling by EGFRvIII 15 7.05e-01 -0.056400 8.25e-01
Signaling by EGFRvIII in Cancer 15 7.05e-01 -0.056400 8.25e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 5.91e-01 0.055800 7.48e-01
FGFR2 alternative splicing 24 6.37e-01 0.055700 7.83e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 26 6.24e-01 -0.055600 7.77e-01
ADORA2B mediated anti-inflammatory cytokines production 36 5.64e-01 0.055600 7.26e-01
PCP/CE pathway 89 3.65e-01 0.055600 5.60e-01
Neurotransmitter receptors and postsynaptic signal transmission 140 2.58e-01 0.055500 4.49e-01
FCGR3A-mediated IL10 synthesis 45 5.20e-01 -0.055400 6.93e-01
Cellular response to chemical stress 179 2.02e-01 -0.055300 3.97e-01
p130Cas linkage to MAPK signaling for integrins 12 7.41e-01 -0.055200 8.51e-01
Assembly of the pre-replicative complex 96 3.54e-01 -0.054800 5.49e-01
Host Interactions of HIV factors 127 2.88e-01 -0.054700 4.79e-01
RNA polymerase II transcribes snRNA genes 71 4.27e-01 0.054500 6.15e-01
Glycogen metabolism 24 6.45e-01 0.054300 7.91e-01
Protein methylation 15 7.16e-01 0.054300 8.34e-01
Cellular response to heat stress 96 3.64e-01 -0.053600 5.59e-01
Translation of Structural Proteins 9694635 57 4.84e-01 -0.053600 6.63e-01
SHC-mediated cascade:FGFR1 13 7.39e-01 0.053400 8.51e-01
Semaphorin interactions 63 4.67e-01 0.053000 6.52e-01
Organelle biogenesis and maintenance 266 1.38e-01 0.052900 3.13e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 7.52e-01 -0.052800 8.58e-01
VEGFR2 mediated vascular permeability 27 6.35e-01 -0.052700 7.83e-01
Visual phototransduction 62 4.74e-01 0.052600 6.55e-01
Budding and maturation of HIV virion 28 6.31e-01 0.052500 7.81e-01
RIPK1-mediated regulated necrosis 29 6.28e-01 -0.052000 7.79e-01
Regulation of necroptotic cell death 29 6.28e-01 -0.052000 7.79e-01
TCR signaling 107 3.53e-01 -0.052000 5.49e-01
Nucleotide-like (purinergic) receptors 15 7.28e-01 0.051900 8.44e-01
Constitutive Signaling by Overexpressed ERBB2 11 7.66e-01 0.051700 8.68e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 6.13e-01 0.051700 7.68e-01
Signal Transduction 2124 1.17e-04 -0.051500 1.63e-03
Sema3A PAK dependent Axon repulsion 16 7.24e-01 0.051000 8.40e-01
Platelet homeostasis 75 4.46e-01 0.050900 6.32e-01
Complement cascade 46 5.51e-01 -0.050800 7.16e-01
ABC-family proteins mediated transport 94 3.95e-01 -0.050800 5.88e-01
HIV Infection 224 1.93e-01 -0.050500 3.86e-01
GPCR downstream signalling 402 8.50e-02 -0.050200 2.32e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 4.56e-01 0.050200 6.42e-01
Negative regulation of FGFR2 signaling 25 6.65e-01 0.050100 8.02e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 178 2.50e-01 0.050100 4.45e-01
Retinoid metabolism and transport 30 6.35e-01 0.050000 7.83e-01
Ion channel transport 142 3.04e-01 0.050000 4.97e-01
Formation of Fibrin Clot (Clotting Cascade) 26 6.61e-01 -0.049700 8.00e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 7.87e-01 0.049200 8.79e-01
Thromboxane signalling through TP receptor 20 7.03e-01 0.049200 8.24e-01
Regulation of TLR by endogenous ligand 15 7.42e-01 -0.049100 8.51e-01
Cytoprotection by HMOX1 58 5.18e-01 -0.049000 6.92e-01
MHC class II antigen presentation 89 4.25e-01 -0.049000 6.14e-01
RAB GEFs exchange GTP for GDP on RABs 88 4.38e-01 -0.047900 6.22e-01
Formation of the cornified envelope 21 7.05e-01 -0.047700 8.25e-01
Signaling by NOTCH3 47 5.74e-01 -0.047400 7.35e-01
GPER1 signaling 37 6.18e-01 0.047300 7.74e-01
TP53 Regulates Metabolic Genes 80 4.69e-01 0.046800 6.54e-01
Interleukin-37 signaling 20 7.17e-01 -0.046700 8.35e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 7.88e-01 0.046700 8.79e-01
IRE1alpha activates chaperones 50 5.69e-01 -0.046500 7.30e-01
Cilium Assembly 179 2.84e-01 0.046500 4.74e-01
Regulation of insulin secretion 65 5.20e-01 0.046200 6.92e-01
Translesion synthesis by POLK 17 7.43e-01 -0.046000 8.51e-01
Constitutive Signaling by Aberrant PI3K in Cancer 63 5.29e-01 -0.045900 6.98e-01
Transmission across Chemical Synapses 189 2.80e-01 0.045600 4.70e-01
Sialic acid metabolism 29 6.71e-01 0.045500 8.06e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 7.60e-01 0.045500 8.64e-01
Regulation of APC/C activators between G1/S and early anaphase 79 4.85e-01 0.045500 6.63e-01
E3 ubiquitin ligases ubiquitinate target proteins 49 5.82e-01 0.045400 7.41e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 5.54e-01 -0.045300 7.16e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 5.54e-01 -0.045300 7.16e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 5.54e-01 -0.045300 7.16e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 5.54e-01 -0.045300 7.16e-01
Signaling by NOTCH1 in Cancer 57 5.54e-01 -0.045300 7.16e-01
Synthesis, secretion, and deacylation of Ghrelin 13 7.78e-01 -0.045200 8.75e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 6.40e-01 0.045000 7.87e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 27 6.87e-01 0.044800 8.14e-01
Trafficking of AMPA receptors 27 6.87e-01 0.044800 8.14e-01
Diseases of signal transduction by growth factor receptors and second messengers 400 1.30e-01 -0.044300 2.99e-01
Negative regulation of FGFR3 signaling 23 7.15e-01 0.044000 8.33e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 7.09e-01 0.044000 8.28e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 28 6.87e-01 0.044000 8.14e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 12 7.92e-01 0.043900 8.82e-01
Lysosome Vesicle Biogenesis 33 6.65e-01 -0.043600 8.02e-01
G alpha (i) signalling events 201 2.91e-01 -0.043300 4.82e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 5.27e-01 0.043200 6.98e-01
B-WICH complex positively regulates rRNA expression 44 6.20e-01 0.043200 7.74e-01
Dual Incision in GG-NER 41 6.33e-01 -0.043100 7.82e-01
Signaling by NOTCH 186 3.13e-01 -0.043000 5.05e-01
Integration of energy metabolism 95 4.71e-01 -0.042800 6.54e-01
ER-Phagosome pathway 79 5.11e-01 0.042800 6.87e-01
G1/S DNA Damage Checkpoints 65 5.51e-01 0.042700 7.16e-01
Downstream signaling of activated FGFR1 22 7.31e-01 0.042400 8.46e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 7.43e-01 -0.042300 8.51e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 7.69e-01 -0.042300 8.70e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 6.89e-01 -0.042200 8.14e-01
Signaling by NOTCH4 81 5.12e-01 0.042100 6.87e-01
Nuclear events stimulated by ALK signaling in cancer 18 7.57e-01 -0.042100 8.63e-01
Cellular responses to stimuli 697 6.18e-02 0.041700 1.88e-01
Assembly Of The HIV Virion 16 7.74e-01 -0.041500 8.74e-01
Programmed Cell Death 194 3.20e-01 -0.041500 5.12e-01
Mitochondrial calcium ion transport 22 7.37e-01 0.041400 8.51e-01
Circadian Clock 67 5.62e-01 -0.041000 7.25e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 8.14e-01 -0.040900 8.98e-01
Nuclear events mediated by NFE2L2 77 5.37e-01 -0.040700 7.05e-01
P2Y receptors 11 8.16e-01 0.040600 8.98e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 22 7.42e-01 0.040600 8.51e-01
TNFR2 non-canonical NF-kB pathway 95 4.95e-01 0.040500 6.73e-01
APC-Cdc20 mediated degradation of Nek2A 26 7.21e-01 0.040500 8.38e-01
Platelet activation, signaling and aggregation 232 2.90e-01 -0.040300 4.82e-01
Metabolism of fat-soluble vitamins 33 6.90e-01 0.040100 8.15e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 7.15e-01 0.039900 8.33e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 6.79e-01 -0.039900 8.09e-01
G alpha (q) signalling events 140 4.16e-01 0.039900 6.07e-01
Glutamate Neurotransmitter Release Cycle 22 7.46e-01 0.039800 8.54e-01
Peptide ligand-binding receptors 92 5.13e-01 -0.039400 6.88e-01
NPAS4 regulates expression of target genes 19 7.66e-01 -0.039400 8.68e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 6.60e-01 0.039200 8.00e-01
HIV Transcription Elongation 42 6.60e-01 0.039200 8.00e-01
Tat-mediated elongation of the HIV-1 transcript 42 6.60e-01 0.039200 8.00e-01
Ion transport by P-type ATPases 46 6.46e-01 0.039100 7.92e-01
Negative regulation of FGFR1 signaling 25 7.37e-01 0.038800 8.51e-01
Synthesis of PIPs at the early endosome membrane 16 7.88e-01 -0.038800 8.79e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 5.93e-01 -0.038700 7.49e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 7.31e-01 -0.038300 8.46e-01
Cellular responses to stress 688 9.01e-02 0.038100 2.39e-01
Activation of NF-kappaB in B cells 65 5.96e-01 0.038000 7.52e-01
p75NTR signals via NF-kB 16 7.97e-01 -0.037100 8.86e-01
XBP1(S) activates chaperone genes 48 6.57e-01 -0.037100 7.99e-01
Maturation of spike protein 9694548 37 6.96e-01 -0.037100 8.20e-01
Receptor Mediated Mitophagy 11 8.33e-01 0.036700 9.12e-01
ATF6 (ATF6-alpha) activates chaperones 12 8.29e-01 0.036100 9.09e-01
Disease 1518 2.05e-02 -0.036000 8.56e-02
Signaling by WNT 262 3.25e-01 -0.035400 5.17e-01
Acyl chain remodelling of PC 21 7.79e-01 -0.035300 8.76e-01
Citric acid cycle (TCA cycle) 22 7.76e-01 0.035100 8.75e-01
Signaling by Non-Receptor Tyrosine Kinases 52 6.67e-01 0.034500 8.03e-01
Signaling by PTK6 52 6.67e-01 0.034500 8.03e-01
Apoptotic execution phase 44 6.92e-01 -0.034500 8.16e-01
Josephin domain DUBs 10 8.51e-01 0.034400 9.23e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 7.32e-01 0.034400 8.47e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 49 6.78e-01 -0.034300 8.09e-01
The canonical retinoid cycle in rods (twilight vision) 12 8.39e-01 0.033900 9.16e-01
Class A/1 (Rhodopsin-like receptors) 167 4.51e-01 -0.033800 6.38e-01
Signaling by NOTCH2 32 7.41e-01 -0.033700 8.51e-01
Tryptophan catabolism 11 8.46e-01 0.033700 9.21e-01
PKA activation 16 8.16e-01 -0.033600 8.98e-01
Voltage gated Potassium channels 21 7.93e-01 -0.033000 8.82e-01
Phase II - Conjugation of compounds 69 6.36e-01 0.032900 7.83e-01
Signaling by GPCR 452 2.36e-01 -0.032600 4.27e-01
Sulfur amino acid metabolism 24 7.82e-01 -0.032600 8.77e-01
Golgi Associated Vesicle Biogenesis 55 6.78e-01 -0.032400 8.09e-01
Other semaphorin interactions 19 8.08e-01 0.032100 8.95e-01
Class I MHC mediated antigen processing & presentation 353 3.03e-01 -0.032000 4.96e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 8.49e-01 -0.031800 9.22e-01
MAPK1/MAPK3 signaling 253 3.87e-01 -0.031700 5.79e-01
PI-3K cascade:FGFR4 12 8.49e-01 -0.031700 9.22e-01
Metabolism of steroids 124 5.50e-01 -0.031100 7.16e-01
Neurotransmitter release cycle 38 7.41e-01 -0.030900 8.51e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 7.70e-01 0.030900 8.70e-01
SARS-CoV-1 Infection 138 5.32e-01 0.030800 7.00e-01
Apoptosis 167 4.93e-01 -0.030800 6.71e-01
Regulated Necrosis 54 6.98e-01 -0.030600 8.21e-01
Gluconeogenesis 28 7.82e-01 0.030300 8.77e-01
Extra-nuclear estrogen signaling 67 6.70e-01 0.030100 8.06e-01
PKA-mediated phosphorylation of CREB 18 8.26e-01 0.029900 9.09e-01
IRAK2 mediated activation of TAK1 complex 10 8.71e-01 0.029700 9.32e-01
Antimicrobial peptides 31 7.75e-01 -0.029700 8.75e-01
MAPK family signaling cascades 289 3.89e-01 -0.029500 5.81e-01
Cyclin A:Cdk2-associated events at S phase entry 85 6.39e-01 -0.029400 7.86e-01
Regulation of FZD by ubiquitination 18 8.29e-01 -0.029400 9.09e-01
Signaling by FGFR3 34 7.67e-01 0.029400 8.68e-01
FRS-mediated FGFR1 signaling 15 8.45e-01 0.029200 9.21e-01
Switching of origins to a post-replicative state 90 6.35e-01 -0.029000 7.83e-01
Orc1 removal from chromatin 69 6.89e-01 -0.027900 8.14e-01
Antigen processing: Ubiquitination & Proteasome degradation 292 4.14e-01 -0.027900 6.05e-01
EPHB-mediated forward signaling 34 7.81e-01 -0.027600 8.77e-01
tRNA modification in the nucleus and cytosol 43 7.55e-01 -0.027600 8.61e-01
Vitamin B5 (pantothenate) metabolism 17 8.45e-01 -0.027400 9.21e-01
ABC transporter disorders 71 6.95e-01 0.026900 8.19e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 8.67e-01 -0.026800 9.31e-01
RAF/MAP kinase cascade 247 4.76e-01 -0.026400 6.55e-01
Glycosphingolipid metabolism 37 7.82e-01 -0.026300 8.77e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 8.62e-01 0.026000 9.28e-01
Cytochrome P450 - arranged by substrate type 40 7.76e-01 -0.026000 8.75e-01
L1CAM interactions 91 6.73e-01 0.025600 8.08e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 8.64e-01 0.024700 9.30e-01
Miscellaneous transport and binding events 21 8.45e-01 0.024600 9.21e-01
Cytochrome c-mediated apoptotic response 13 8.79e-01 -0.024300 9.37e-01
Intra-Golgi traffic 41 7.88e-01 0.024300 8.79e-01
Transcriptional regulation of pluripotent stem cells 21 8.47e-01 0.024300 9.21e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.52e-01 -0.024100 9.23e-01
Inhibition of DNA recombination at telomere 33 8.14e-01 -0.023700 8.98e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 8.87e-01 0.023600 9.40e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 8.60e-01 0.023400 9.28e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 8.12e-01 0.023300 8.97e-01
NoRC negatively regulates rRNA expression 59 7.59e-01 0.023100 8.63e-01
DAG and IP3 signaling 38 8.10e-01 -0.022500 8.96e-01
Regulation of Complement cascade 41 8.04e-01 -0.022400 8.92e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 7.99e-01 0.022200 8.87e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 8.57e-01 0.021700 9.27e-01
Interleukin-12 family signaling 51 7.90e-01 -0.021500 8.80e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 8.68e-01 0.020900 9.31e-01
Hyaluronan uptake and degradation 12 9.02e-01 -0.020500 9.44e-01
Thrombin signalling through proteinase activated receptors (PARs) 26 8.57e-01 -0.020400 9.27e-01
Infectious disease 848 3.22e-01 -0.020100 5.14e-01
Opioid Signalling 81 7.57e-01 -0.019900 8.63e-01
Interleukin-6 family signaling 22 8.73e-01 -0.019700 9.33e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 80 7.65e-01 -0.019300 8.68e-01
Signaling by TGFB family members 113 7.24e-01 0.019300 8.40e-01
GPCR ligand binding 241 6.08e-01 0.019200 7.62e-01
Cohesin Loading onto Chromatin 10 9.17e-01 -0.019000 9.55e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 8.86e-01 0.018900 9.40e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 8.86e-01 0.018900 9.40e-01
trans-Golgi Network Vesicle Budding 70 7.85e-01 -0.018800 8.79e-01
Signaling by VEGF 102 7.46e-01 -0.018600 8.53e-01
Signaling by ERBB2 ECD mutants 16 8.98e-01 0.018600 9.42e-01
Vasopressin regulates renal water homeostasis via Aquaporins 35 8.52e-01 0.018200 9.23e-01
Negative regulation of FGFR4 signaling 23 8.81e-01 -0.018000 9.38e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 8.98e-01 -0.018000 9.42e-01
Platelet calcium homeostasis 23 8.82e-01 -0.017900 9.38e-01
VEGFA-VEGFR2 Pathway 94 7.67e-01 -0.017700 8.68e-01
Azathioprine ADME 19 8.95e-01 -0.017600 9.42e-01
MicroRNA (miRNA) biogenesis 25 8.80e-01 0.017500 9.37e-01
C-type lectin receptors (CLRs) 125 7.40e-01 -0.017200 8.51e-01
Phosphorylation of the APC/C 20 8.94e-01 -0.017200 9.42e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 9.09e-01 -0.017100 9.49e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 7.87e-01 0.017100 8.79e-01
Cyclin E associated events during G1/S transition 83 7.91e-01 -0.016900 8.80e-01
Signaling by FGFR in disease 53 8.32e-01 0.016800 9.12e-01
O-linked glycosylation of mucins 45 8.47e-01 0.016600 9.21e-01
Peroxisomal protein import 58 8.29e-01 -0.016400 9.09e-01
Metabolism of vitamins and cofactors 164 7.26e-01 -0.015900 8.42e-01
Autophagy 127 7.58e-01 -0.015800 8.63e-01
Metabolism of folate and pterines 17 9.11e-01 0.015700 9.50e-01
Nucleotide Excision Repair 110 7.78e-01 -0.015600 8.75e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 9.13e-01 -0.015400 9.51e-01
FCERI mediated NF-kB activation 81 8.12e-01 -0.015300 8.97e-01
PERK regulates gene expression 32 8.83e-01 -0.015000 9.38e-01
Macroautophagy 112 7.85e-01 -0.015000 8.79e-01
RNA Polymerase II Pre-transcription Events 78 8.29e-01 -0.014200 9.09e-01
Trafficking of GluR2-containing AMPA receptors 16 9.22e-01 0.014100 9.60e-01
mRNA Splicing - Minor Pathway 50 8.68e-01 -0.013600 9.31e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 8.98e-01 0.013500 9.42e-01
Glucagon signaling in metabolic regulation 27 9.05e-01 0.013200 9.46e-01
DNA Damage Recognition in GG-NER 38 8.89e-01 -0.013100 9.41e-01
VxPx cargo-targeting to cilium 18 9.23e-01 -0.013100 9.61e-01
SHC-mediated cascade:FGFR4 12 9.37e-01 0.013100 9.68e-01
N-Glycan antennae elongation 13 9.36e-01 -0.012900 9.68e-01
Fertilization 10 9.44e-01 -0.012900 9.70e-01
PECAM1 interactions 12 9.39e-01 0.012800 9.68e-01
Downstream TCR signaling 86 8.40e-01 0.012600 9.17e-01
RHO GTPases Activate ROCKs 19 9.24e-01 -0.012600 9.61e-01
RND3 GTPase cycle 38 8.94e-01 -0.012500 9.42e-01
Antigen processing-Cross presentation 93 8.35e-01 0.012500 9.14e-01
Mitochondrial iron-sulfur cluster biogenesis 13 9.38e-01 -0.012400 9.68e-01
Transcription of the HIV genome 67 8.61e-01 0.012400 9.28e-01
Transcriptional regulation by RUNX3 95 8.35e-01 0.012300 9.14e-01
Signaling by Hippo 20 9.25e-01 0.012100 9.61e-01
PI-3K cascade:FGFR1 13 9.40e-01 0.012100 9.69e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 8.82e-01 0.012000 9.38e-01
Adenylate cyclase inhibitory pathway 12 9.44e-01 0.011700 9.70e-01
Chaperonin-mediated protein folding 79 8.63e-01 -0.011200 9.29e-01
Signaling by ERBB4 52 8.89e-01 0.011200 9.41e-01
Aquaporin-mediated transport 38 9.06e-01 -0.011100 9.46e-01
RNA Polymerase I Promoter Clearance 63 8.80e-01 -0.011000 9.37e-01
RNA Polymerase I Transcription 63 8.80e-01 -0.011000 9.37e-01
APC/C-mediated degradation of cell cycle proteins 86 8.61e-01 0.010900 9.28e-01
Regulation of mitotic cell cycle 86 8.61e-01 0.010900 9.28e-01
Stimuli-sensing channels 77 8.69e-01 -0.010900 9.31e-01
SLC-mediated transmembrane transport 174 8.05e-01 0.010900 8.92e-01
Signaling by NTRK2 (TRKB) 23 9.28e-01 -0.010800 9.64e-01
Mitochondrial tRNA aminoacylation 21 9.33e-01 -0.010600 9.66e-01
UCH proteinases 88 8.66e-01 -0.010400 9.31e-01
Signaling by ALK fusions and activated point mutants 54 8.97e-01 0.010100 9.42e-01
Signaling by ALK in cancer 54 8.97e-01 0.010100 9.42e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.39e-01 -0.009930 9.68e-01
Synthesis of bile acids and bile salts 27 9.32e-01 -0.009480 9.66e-01
Negative epigenetic regulation of rRNA expression 62 8.98e-01 -0.009420 9.42e-01
Vesicle-mediated transport 614 7.00e-01 0.009130 8.22e-01
Protein ubiquitination 69 8.98e-01 -0.008890 9.42e-01
Sphingolipid metabolism 77 8.96e-01 -0.008580 9.42e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 9.54e-01 -0.008540 9.79e-01
Signaling by TGF-beta Receptor Complex 89 8.93e-01 -0.008280 9.42e-01
Downstream signaling of activated FGFR4 19 9.50e-01 0.008260 9.76e-01
Sphingolipid de novo biosynthesis 40 9.31e-01 0.007870 9.66e-01
Protein folding 85 9.03e-01 0.007670 9.44e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 9.03e-01 0.007590 9.44e-01
FRS-mediated FGFR4 signaling 14 9.63e-01 -0.007120 9.85e-01
Post-translational protein modification 1226 6.79e-01 0.007070 8.09e-01
SARS-CoV-2 Infection 267 8.68e-01 -0.005910 9.31e-01
SUMOylation of transcription factors 16 9.68e-01 -0.005750 9.88e-01
SARS-CoV-2-host interactions 174 8.98e-01 0.005630 9.42e-01
Metabolism of RNA 662 8.06e-01 0.005620 8.92e-01
Carboxyterminal post-translational modifications of tubulin 28 9.59e-01 0.005600 9.82e-01
Pyroptosis 25 9.62e-01 -0.005560 9.84e-01
Metabolism of carbohydrates 259 8.79e-01 -0.005520 9.37e-01
Apoptotic cleavage of cellular proteins 36 9.55e-01 -0.005400 9.79e-01
Activation of RAC1 12 9.75e-01 0.005190 9.90e-01
Processing of SMDT1 15 9.73e-01 -0.005010 9.90e-01
G alpha (12/13) signalling events 70 9.43e-01 -0.004950 9.70e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 9.79e-01 0.004810 9.90e-01
TNFs bind their physiological receptors 25 9.68e-01 0.004650 9.88e-01
Metabolism 1798 7.47e-01 0.004640 8.54e-01
Signaling by EGFR in Cancer 24 9.69e-01 -0.004600 9.88e-01
Signaling by FGFR4 33 9.64e-01 -0.004520 9.86e-01
Unfolded Protein Response (UPR) 91 9.42e-01 0.004380 9.70e-01
Transport of small molecules 569 8.73e-01 -0.003930 9.33e-01
G beta:gamma signalling through CDC42 16 9.79e-01 -0.003780 9.90e-01
Post-chaperonin tubulin folding pathway 17 9.79e-01 0.003680 9.90e-01
Degradation of beta-catenin by the destruction complex 83 9.54e-01 -0.003680 9.79e-01
Glycogen storage diseases 14 9.82e-01 0.003560 9.90e-01
COPI-independent Golgi-to-ER retrograde traffic 33 9.72e-01 0.003490 9.90e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.81e-01 0.003040 9.90e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.81e-01 0.003040 9.90e-01
ALK mutants bind TKIs 11 9.87e-01 -0.002740 9.93e-01
Acyl chain remodelling of PE 21 9.83e-01 0.002620 9.90e-01
RND1 GTPase cycle 39 9.78e-01 -0.002540 9.90e-01
Sema4D in semaphorin signaling 24 9.83e-01 -0.002500 9.90e-01
G alpha (z) signalling events 38 9.79e-01 -0.002470 9.90e-01
Formation of RNA Pol II elongation complex 57 9.77e-01 -0.002250 9.90e-01
RNA Polymerase II Transcription Elongation 57 9.77e-01 -0.002250 9.90e-01
Signaling by Insulin receptor 64 9.77e-01 -0.002060 9.90e-01
CaMK IV-mediated phosphorylation of CREB 10 9.91e-01 0.001990 9.94e-01
Membrane Trafficking 576 9.36e-01 0.001970 9.68e-01
Signaling by MET 63 9.79e-01 -0.001880 9.90e-01
Interleukin-12 signaling 44 9.87e-01 0.001390 9.93e-01
CLEC7A (Dectin-1) signaling 96 9.83e-01 0.001270 9.90e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 9.94e-01 0.001210 9.96e-01
Signaling by Receptor Tyrosine Kinases 461 9.67e-01 0.001120 9.88e-01
MTOR signalling 40 9.91e-01 0.000988 9.94e-01
Dual incision in TC-NER 65 9.89e-01 0.000973 9.94e-01
Sema4D induced cell migration and growth-cone collapse 20 9.95e-01 -0.000811 9.96e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 9.91e-01 0.000702 9.94e-01
Hyaluronan metabolism 17 9.96e-01 0.000670 9.97e-01
Defects in vitamin and cofactor metabolism 21 9.98e-01 0.000356 9.98e-01


Detailed Gene set reports



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
373
set Eukaryotic Translation Elongation
setSize 93
pANOVA 4.09e-29
s.dist 0.671
p.adjustANOVA 6.03e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
EEF1A2 9575
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
EEF1A1P5 8473
RPL13A 8446
EEF1A1 8334
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EEF1A2 9575
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
EEF1A1P5 8473
RPL13A 8446
EEF1A1 8334
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
EEF1D 7029
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
EEF1B2 6515
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
EEF1G 6452
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
RPS21 4818
RPS14 4721
RPL36A 3933
RPL38 3656
RPS2 3554
EEF2 2631
RPS16 1728
RPS4Y1 89


Peptide chain elongation

Peptide chain elongation
857
set Peptide chain elongation
setSize 88
pANOVA 3.13e-27
s.dist 0.666
p.adjustANOVA 1.74e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
EEF1A1 8334
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
EEF1A1 8334
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
RPS21 4818
RPS14 4721
RPL36A 3933
RPL38 3656
RPS2 3554
EEF2 2631
RPS16 1728
RPS4Y1 89


Viral mRNA Translation

Viral mRNA Translation
1424
set Viral mRNA Translation
setSize 88
pANOVA 3.54e-27
s.dist 0.665
p.adjustANOVA 1.74e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNAJC3 9671
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNAJC3 9671
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
RPS21 4818
RPS14 4721
RPL36A 3933
RPL38 3656
RPS2 3554
RPS16 1728
GRSF1 762
RPS4Y1 89


Selenocysteine synthesis

Selenocysteine synthesis
1146
set Selenocysteine synthesis
setSize 92
pANOVA 3.09e-25
s.dist 0.625
p.adjustANOVA 6.51e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
SEPSECS 9259
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
SEPSECS 9259
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
RPS21 4818
RPS14 4721
RPL36A 3933
SARS1 3900
RPL38 3656
RPS2 3554
RPS16 1728
RPS4Y1 89
EEFSEC -121
PSTK -991
SEPHS2 -2575
SECISBP2 -3628


Eukaryotic Translation Termination

Eukaryotic Translation Termination
375
set Eukaryotic Translation Termination
setSize 92
pANOVA 1.79e-24
s.dist 0.615
p.adjustANOVA 2.64e-22



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
RPS21 4818
RPS14 4721
RPL36A 3933
RPL38 3656
RPS2 3554
N6AMT1 2097
TRMT112 1824
RPS16 1728
ETF1 1341
GSPT2 1304
RPS4Y1 89
GSPT1 -4195
APEH -4605


Unwinding of DNA

Unwinding of DNA
1413
set Unwinding of DNA
setSize 12
pANOVA 0.000228
s.dist -0.614
p.adjustANOVA 0.00265



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM5 -7363
MCM7 -7222
MCM3 -7208
MCM4 -6917
MCM2 -6804
MCM6 -5167
MCM8 -4757
CDC45 -4240
GINS4 -3439
GINS1 -1688
GINS2 -698
GINS3 3697

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM5 -7363
MCM7 -7222
MCM3 -7208
MCM4 -6917
MCM2 -6804
MCM6 -5167
MCM8 -4757
CDC45 -4240
GINS4 -3439
GINS1 -1688
GINS2 -698
GINS3 3697


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
418
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 3.23e-26
s.dist 0.612
p.adjustANOVA 7.93e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
EIF3I 7766
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
EIF3H 6755
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
RPL36A 3933
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPL38 3656
RPS2 3554
EIF3D 2504
RPS16 1728
RPS4Y1 89
EIF3C -6235
EIF3B -6335
EIF3A -6487


Collagen biosynthesis and modifying enzymes

Collagen biosynthesis and modifying enzymes
207
set Collagen biosynthesis and modifying enzymes
setSize 62
pANOVA 1.03e-16
s.dist 0.609
p.adjustANOVA 7.2e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL9A1 9705
COL27A1 9467
COL15A1 9463
COL5A1 9456
COLGALT2 9452
COL11A2 9415
COL19A1 9410
P4HA3 9392
ADAMTS14 9353
COL6A3 9345
COL1A1 9334
PCOLCE 9331
COL9A3 9330
COL11A1 9320
P4HA2 9293
COL3A1 9256
COL22A1 9237
COL1A2 9227
COL6A2 9213
BMP1 9067

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL9A1 9705
COL27A1 9467
COL15A1 9463
COL5A1 9456
COLGALT2 9452
COL11A2 9415
COL19A1 9410
P4HA3 9392
ADAMTS14 9353
COL6A3 9345
COL1A1 9334
PCOLCE 9331
COL9A3 9330
COL11A1 9320
P4HA2 9293
COL3A1 9256
COL22A1 9237
COL1A2 9227
COL6A2 9213
BMP1 9067
COL6A1 9042
COL5A2 8936
COL10A1 8905
ADAMTS2 8870
SERPINH1 8814
P3H1 8772
PLOD2 8741
P4HA1 8614
P3H3 8421
COL16A1 8379
COL24A1 8357
PLOD1 8160
P3H2 7925
PPIB 7713
COL26A1 7625
COL4A1 7489
COL4A2 7172
COL7A1 6859
COL4A5 6803
CRTAP 6124
COL9A2 5791
TLL1 5218
PCOLCE2 5049
COL13A1 5004
COL4A3 4483
COL8A2 4213
COL2A1 4145
COL18A1 4038
ADAMTS3 3835
COL12A1 3710
PLOD3 3163
COL25A1 2070
COL14A1 2002
COL5A3 1859
COL8A1 867
COL21A1 588
COL17A1 -867
COLGALT1 -1198
COL4A4 -1289
P4HB -1608
COL28A1 -1815
COL23A1 -7126


CS/DS degradation

CS/DS degradation
142
set CS/DS degradation
setSize 11
pANOVA 0.000492
s.dist 0.607
p.adjustANOVA 0.00518



Top enriched genes

Top 20 genes
GeneID Gene Rank
HEXA 9623
BGN 9356
DCN 9167
CSPG4 8751
ARSB 8647
IDS 8350
HYAL1 8029
HEXB 6123
IDUA 3251
VCAN -719
HYAL3 -1286

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HEXA 9623
BGN 9356
DCN 9167
CSPG4 8751
ARSB 8647
IDS 8350
HYAL1 8029
HEXB 6123
IDUA 3251
VCAN -719
HYAL3 -1286


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1099
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 4.56e-10
s.dist 0.6
p.adjustANOVA 1.68e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
EEF1A1 8334
RPS26 8270
RPS27 8063
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
RPS23 6945
RPS9 6881
RPS5 6852
RPS27A 6798

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EEF1A1 8334
RPS26 8270
RPS27 8063
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
RPS23 6945
RPS9 6881
RPS5 6852
RPS27A 6798
RPS11 6786
RPS20 6550
RPS4X 6478
RPS10 6378
RPS12 6252
RPS28 6220
RPS29 5883
RPS3 5459
RPS25 5401
RPSA 4938
RPS21 4818
RPS14 4721
RPS2 3554
RPS16 1728
RPS4Y1 89
HNRNPA1 -1291


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1084
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 4.42e-25
s.dist 0.598
p.adjustANOVA 7.87e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
CEBPG 9152
RPL9 9124
DDIT3 8953
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
CEBPG 9152
RPL9 9124
DDIT3 8953
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
EIF2S2 5073
EIF2S1 4953
RPSA 4938
RPS21 4818
ATF4 4728
RPS14 4721
RPL36A 3933
RPL38 3656
CEBPB 3654
RPS2 3554
IMPACT 2854
ATF2 2606
EIF2AK4 2309
RPS16 1728
ATF3 210
ASNS 197
RPS4Y1 89
EIF2S3 -2159
GCN1 -3750
TRIB3 -5363


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
788
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 1.73e-23
s.dist 0.596
p.adjustANOVA 1.96e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
NCBP1 4894
RPS21 4818
RPS14 4721
RPL36A 3933
NCBP2 3872
RPL38 3656
RPS2 3554
RPS16 1728
ETF1 1341
GSPT2 1304
RPS4Y1 89
EIF4G1 -3271
GSPT1 -4195
UPF1 -4676
PABPC1 -4951


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1124
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 1.23e-26
s.dist 0.586
p.adjustANOVA 4.54e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
SSR2 9117
RPL26L1 8820
RPL26 8722
SRPRB 8718
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
SEC11A 7932
RPS17 7867
SRP14 7853

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
SSR2 9117
RPL26L1 8820
RPL26 8722
SRPRB 8718
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
SEC11A 7932
RPS17 7867
SRP14 7853
RPS18 7844
TRAM1 7832
RPL29 7831
SSR3 7822
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
SSR1 7020
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
SEC61B 6833
SRP72 6829
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
SRP19 5765
RPL3 5673
SEC61G 5597
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
RPSA 4938
RPN1 4905
RPS21 4818
RPS14 4721
RPL36A 3933
SRP9 3883
RPL38 3656
SPCS3 3557
RPS2 3554
SSR4 3165
SEC11C 2627
SEC61A1 2341
SRP54 1996
RPS16 1728
SPCS1 1326
RPS4Y1 89
SPCS2 -195
DDOST -274
RPN2 -594
SRPRA -3413
SEC61A2 -4486
SRP68 -6226


Interleukin-15 signaling

Interleukin-15 signaling
593
set Interleukin-15 signaling
setSize 14
pANOVA 0.000148
s.dist -0.586
p.adjustANOVA 0.00193



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT5A -7611
STAT5B -7538
GAB2 -6870
IL15RA -6618
JAK1 -6017
IL2RG -5447
GRB2 -5320
JAK3 -4424
SOS1 -4390
SOS2 -1319
STAT3 -1313
IL2RB -998
SHC1 -450
IL15 1390

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT5A -7611
STAT5B -7538
GAB2 -6870
IL15RA -6618
JAK1 -6017
IL2RG -5447
GRB2 -5320
JAK3 -4424
SOS1 -4390
SOS2 -1319
STAT3 -1313
IL2RB -998
SHC1 -450
IL15 1390


Interleukin-2 signaling

Interleukin-2 signaling
596
set Interleukin-2 signaling
setSize 11
pANOVA 0.000788
s.dist -0.584
p.adjustANOVA 0.00768



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT5A -7611
STAT5B -7538
PTK2B -7085
JAK1 -6017
IL2RG -5447
SYK -4606
JAK3 -4424
LCK -1195
IL2RB -998
SHC1 -450
IL2RA 737

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT5A -7611
STAT5B -7538
PTK2B -7085
JAK1 -6017
IL2RG -5447
SYK -4606
JAK3 -4424
LCK -1195
IL2RB -998
SHC1 -450
IL2RA 737


Keratan sulfate degradation

Keratan sulfate degradation
622
set Keratan sulfate degradation
setSize 11
pANOVA 0.000805
s.dist 0.583
p.adjustANOVA 0.00768



Top enriched genes

Top 20 genes
GeneID Gene Rank
HEXA 9623
OGN 9620
ACAN 9563
FMOD 9435
LUM 8806
PRELP 8648
OMD 7289
HEXB 6123
GNS 3012
GLB1L -1000
GLB1 -4054

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HEXA 9623
OGN 9620
ACAN 9563
FMOD 9435
LUM 8806
PRELP 8648
OMD 7289
HEXB 6123
GNS 3012
GLB1L -1000
GLB1 -4054


Assembly of collagen fibrils and other multimeric structures

Assembly of collagen fibrils and other multimeric structures
92
set Assembly of collagen fibrils and other multimeric structures
setSize 51
pANOVA 7.73e-13
s.dist 0.58
p.adjustANOVA 3.56e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL9A1 9705
LOXL4 9493
COL27A1 9467
COL15A1 9463
COL5A1 9456
COL11A2 9415
COL6A3 9345
COL1A1 9334
PCOLCE 9331
COL9A3 9330
COL11A1 9320
LOX 9264
COL3A1 9256
COL1A2 9227
COL6A2 9213
MMP13 9115
BMP1 9067
COL6A1 9042
COL5A2 8936
COL10A1 8905

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL9A1 9705
LOXL4 9493
COL27A1 9467
COL15A1 9463
COL5A1 9456
COL11A2 9415
COL6A3 9345
COL1A1 9334
PCOLCE 9331
COL9A3 9330
COL11A1 9320
LOX 9264
COL3A1 9256
COL1A2 9227
COL6A2 9213
MMP13 9115
BMP1 9067
COL6A1 9042
COL5A2 8936
COL10A1 8905
LOXL2 8533
COL24A1 8357
DST 8178
COL4A1 7489
COL4A2 7172
MMP9 6948
COL7A1 6859
COL4A5 6803
MMP3 6275
LOXL1 5932
COL9A2 5791
ITGB4 5565
TLL1 5218
PXDN 4970
COL4A3 4483
COL8A2 4213
COL2A1 4145
COL18A1 4038
CTSS 3347
LOXL3 3141
PLEC 2562
ITGA6 2157
COL5A3 1859
LAMB3 1804
CTSB 1430
COL8A1 867
LAMA3 191
CD151 -969
CTSL -1108
COL4A4 -1289
CTSV -1940


RIP-mediated NFkB activation via ZBP1

RIP-mediated NFkB activation via ZBP1
963
set RIP-mediated NFkB activation via ZBP1
setSize 17
pANOVA 4.39e-05
s.dist -0.572
p.adjustANOVA 0.000688



Top enriched genes

Top 20 genes
GeneID Gene Rank
IKBKB -6286
MYD88 -6202
NFKB1 -6141
RIPK3 -5397
NFKB2 -5158
NFKBIB -4880
IKBKG -4693
ZBP1 -4548
NFKBIA -4538
TICAM1 -4504
TLR3 -4371
RIPK1 -4322
NKIRAS2 -3779
DHX9 -2931
RELA -415
CHUK -344
NKIRAS1 1355

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IKBKB -6286
MYD88 -6202
NFKB1 -6141
RIPK3 -5397
NFKB2 -5158
NFKBIB -4880
IKBKG -4693
ZBP1 -4548
NFKBIA -4538
TICAM1 -4504
TLR3 -4371
RIPK1 -4322
NKIRAS2 -3779
DHX9 -2931
RELA -415
CHUK -344
NKIRAS1 1355


Collagen chain trimerization

Collagen chain trimerization
208
set Collagen chain trimerization
setSize 40
pANOVA 4.78e-10
s.dist 0.569
p.adjustANOVA 1.72e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL9A1 9705
COL27A1 9467
COL15A1 9463
COL5A1 9456
COL11A2 9415
COL19A1 9410
COL6A3 9345
COL1A1 9334
COL9A3 9330
COL11A1 9320
COL3A1 9256
COL22A1 9237
COL1A2 9227
COL6A2 9213
COL6A1 9042
COL5A2 8936
COL10A1 8905
COL16A1 8379
COL24A1 8357
COL26A1 7625

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL9A1 9705
COL27A1 9467
COL15A1 9463
COL5A1 9456
COL11A2 9415
COL19A1 9410
COL6A3 9345
COL1A1 9334
COL9A3 9330
COL11A1 9320
COL3A1 9256
COL22A1 9237
COL1A2 9227
COL6A2 9213
COL6A1 9042
COL5A2 8936
COL10A1 8905
COL16A1 8379
COL24A1 8357
COL26A1 7625
COL4A1 7489
COL4A2 7172
COL7A1 6859
COL4A5 6803
COL9A2 5791
COL13A1 5004
COL4A3 4483
COL8A2 4213
COL2A1 4145
COL18A1 4038
COL12A1 3710
COL25A1 2070
COL14A1 2002
COL5A3 1859
COL8A1 867
COL21A1 588
COL17A1 -867
COL4A4 -1289
COL28A1 -1815
COL23A1 -7126


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
463
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 4.81e-25
s.dist 0.567
p.adjustANOVA 7.87e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
EIF3I 7766
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
EIF4A2 6958
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
EIF3H 6755
RPLP1 6753
RPL27 6738
EIF4E 6570
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
EIF5B 5626
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
EIF2S2 5073
EIF2S1 4953
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
EIF5 4486
EIF4A1 4374
RPL36A 3933
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPL38 3656
RPS2 3554
EIF3D 2504
RPS16 1728
RPS4Y1 89
EIF4B -1877
EIF2S3 -2159
EIF4G1 -3271
EIF4H -4704
EIF3C -6235
EIF3B -6335
EIF3A -6487


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
627
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 4.75e-24
s.dist 0.558
p.adjustANOVA 5.83e-22



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
EIF3I 7766
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
EIF4A2 6958
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
EIF3H 6755
RPLP1 6753
RPL27 6738
EIF4E 6570
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
EIF2S2 5073
EIF2S1 4953
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
EIF4A1 4374
RPL36A 3933
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPL38 3656
RPS2 3554
EIF3D 2504
RPS16 1728
RPS4Y1 89
EIF4B -1877
EIF2S3 -2159
EIF4G1 -3271
EIF4H -4704
PABPC1 -4951
EIF3C -6235
EIF3B -6335
EIF3A -6487


Collagen formation

Collagen formation
210
set Collagen formation
setSize 82
pANOVA 5.42e-18
s.dist 0.552
p.adjustANOVA 4.18e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL9A1 9705
LOXL4 9493
COL27A1 9467
COL15A1 9463
COL5A1 9456
COLGALT2 9452
COL11A2 9415
COL19A1 9410
P4HA3 9392
ADAMTS14 9353
COL6A3 9345
COL1A1 9334
PCOLCE 9331
COL9A3 9330
COL11A1 9320
P4HA2 9293
LOX 9264
COL3A1 9256
COL22A1 9237
COL1A2 9227

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL9A1 9705
LOXL4 9493
COL27A1 9467
COL15A1 9463
COL5A1 9456
COLGALT2 9452
COL11A2 9415
COL19A1 9410
P4HA3 9392
ADAMTS14 9353
COL6A3 9345
COL1A1 9334
PCOLCE 9331
COL9A3 9330
COL11A1 9320
P4HA2 9293
LOX 9264
COL3A1 9256
COL22A1 9237
COL1A2 9227
COL6A2 9213
MMP13 9115
BMP1 9067
COL6A1 9042
COL5A2 8936
COL10A1 8905
ADAMTS2 8870
SERPINH1 8814
P3H1 8772
PLOD2 8741
P4HA1 8614
LOXL2 8533
P3H3 8421
COL16A1 8379
COL24A1 8357
DST 8178
PLOD1 8160
P3H2 7925
PPIB 7713
COL26A1 7625
COL4A1 7489
COL4A2 7172
MMP9 6948
COL7A1 6859
COL4A5 6803
MMP3 6275
CRTAP 6124
LOXL1 5932
COL9A2 5791
ITGB4 5565
TLL1 5218
PCOLCE2 5049
COL13A1 5004
PXDN 4970
COL4A3 4483
COL8A2 4213
COL2A1 4145
COL18A1 4038
ADAMTS3 3835
COL12A1 3710
CTSS 3347
PLOD3 3163
LOXL3 3141
PLEC 2562
ITGA6 2157
COL25A1 2070
COL14A1 2002
COL5A3 1859
LAMB3 1804
CTSB 1430
COL8A1 867
COL21A1 588
LAMA3 191
COL17A1 -867
CD151 -969
CTSL -1108
COLGALT1 -1198
COL4A4 -1289
P4HB -1608
COL28A1 -1815
CTSV -1940
COL23A1 -7126


Selenoamino acid metabolism

Selenoamino acid metabolism
1145
set Selenoamino acid metabolism
setSize 114
pANOVA 4.38e-24
s.dist 0.548
p.adjustANOVA 5.83e-22



Top enriched genes

Top 20 genes
GeneID Gene Rank
PAPSS2 9649
RPL17 9371
SEPSECS 9259
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RARS1 8705
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
EPRS1 8199
RPL35 8123
RPS27 8063
DARS1 8042
RPL10 8039
RPS24 7991
RPL41 7964

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAPSS2 9649
RPL17 9371
SEPSECS 9259
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RARS1 8705
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
EPRS1 8199
RPL35 8123
RPS27 8063
DARS1 8042
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
LARS1 7740
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
AIMP1 7094
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
IARS1 6531
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
KARS1 6095
RPL36AL 6056
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
EEF1E1 5399
RPLP2 5338
RPL28 5311
AIMP2 5130
RPSA 4938
RPS21 4818
RPS14 4721
CBS 4397
RPL36A 3933
SARS1 3900
RPL38 3656
PAPSS1 3652
RPS2 3554
SCLY 3228
NNMT 3227
RPS16 1728
QARS1 1506
RPS4Y1 89
EEFSEC -121
AHCY -617
PSTK -991
TXNRD1 -1611
SEPHS2 -2575
SECISBP2 -3628
MARS1 -3661
CTH -3849
HNMT -3887
GSR -3990
INMT -6084


Polo-like kinase mediated events

Polo-like kinase mediated events
884
set Polo-like kinase mediated events
setSize 16
pANOVA 2e-04
s.dist -0.537
p.adjustANOVA 0.00238



Top enriched genes

Top 20 genes
GeneID Gene Rank
PKMYT1 -7336
EP300 -6823
PLK1 -6751
FOXM1 -6562
MYBL2 -6511
CDC25A -6353
WEE1 -6090
RBBP4 -3695
CENPF -3058
CCNB1 -2502
LIN52 -1636
CDC25C -1565
CCNB2 -751
LIN37 -713
LIN54 -102
LIN9 2163

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PKMYT1 -7336
EP300 -6823
PLK1 -6751
FOXM1 -6562
MYBL2 -6511
CDC25A -6353
WEE1 -6090
RBBP4 -3695
CENPF -3058
CCNB1 -2502
LIN52 -1636
CDC25C -1565
CCNB2 -751
LIN37 -713
LIN54 -102
LIN9 2163


HDMs demethylate histones

HDMs demethylate histones
507
set HDMs demethylate histones
setSize 21
pANOVA 2.2e-05
s.dist -0.535
p.adjustANOVA 0.00039



Top enriched genes

Top 20 genes
GeneID Gene Rank
KDM4A -7648
KDM3B -7519
PHF8 -6801
KDM2B -6764
KDM4C -6644
KDM6B -5665
KDM2A -5102
KDM4B -4535
JMJD6 -4432
KDM5C -4394
PHF2 -3612
KDM1B -3533
KDM5B -3483
KDM3A -2558
KDM7A -1279
KDM1A -1273
KDM5A -975
KDM6A -787
ARID5B -8
KDM5D 252

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KDM4A -7648
KDM3B -7519
PHF8 -6801
KDM2B -6764
KDM4C -6644
KDM6B -5665
KDM2A -5102
KDM4B -4535
JMJD6 -4432
KDM5C -4394
PHF2 -3612
KDM1B -3533
KDM5B -3483
KDM3A -2558
KDM7A -1279
KDM1A -1273
KDM5A -975
KDM6A -787
ARID5B -8
KDM5D 252
UTY 660


FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes
396
set FOXO-mediated transcription of cell death genes
setSize 16
pANOVA 0.000267
s.dist -0.526
p.adjustANOVA 0.00301



Top enriched genes

Top 20 genes
GeneID Gene Rank
CITED2 -7382
STK11 -7133
NFYC -7040
NFYA -6836
BCL2L11 -6830
EP300 -6823
FOXO4 -6355
CREBBP -5646
BBC3 -5312
BCL6 -5253
PINK1 -4940
FOXO3 -4929
NFYB -135
FASLG 2509
FOXO1 6346
DDIT3 8953

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CITED2 -7382
STK11 -7133
NFYC -7040
NFYA -6836
BCL2L11 -6830
EP300 -6823
FOXO4 -6355
CREBBP -5646
BBC3 -5312
BCL6 -5253
PINK1 -4940
FOXO3 -4929
NFYB -135
FASLG 2509
FOXO1 6346
DDIT3 8953


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
154
set Cap-dependent Translation Initiation
setSize 118
pANOVA 9.28e-23
s.dist 0.523
p.adjustANOVA 9.11e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
EIF2B2 8943
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
EIF2B2 8943
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
EIF3I 7766
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
EIF4A2 6958
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
EIF3H 6755
RPLP1 6753
RPL27 6738
EIF4E 6570
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
EIF5B 5626
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
EIF2S2 5073
EIF2S1 4953
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
EIF5 4486
EIF4A1 4374
RPL36A 3933
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPL38 3656
RPS2 3554
EIF3D 2504
RPS16 1728
EIF4EBP1 1202
RPS4Y1 89
EIF2B3 -431
EIF4B -1877
EIF2S3 -2159
EIF2B5 -2389
EIF2B4 -2630
EIF4G1 -3271
EIF2B1 -3781
EIF4H -4704
PABPC1 -4951
EIF3C -6235
EIF3B -6335
EIF3A -6487


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
374
set Eukaryotic Translation Initiation
setSize 118
pANOVA 9.28e-23
s.dist 0.523
p.adjustANOVA 9.11e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
EIF2B2 8943
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
RPL17 9371
RPL3L 9214
EIF3G 9208
RPL9 9124
EIF2B2 8943
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
EIF3E 8036
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
EIF3I 7766
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
EIF4A2 6958
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
EIF3H 6755
RPLP1 6753
RPL27 6738
EIF4E 6570
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
RPS29 5883
RPL3 5673
EIF5B 5626
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
EIF2S2 5073
EIF2S1 4953
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
EIF5 4486
EIF4A1 4374
RPL36A 3933
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPL38 3656
RPS2 3554
EIF3D 2504
RPS16 1728
EIF4EBP1 1202
RPS4Y1 89
EIF2B3 -431
EIF4B -1877
EIF2S3 -2159
EIF2B5 -2389
EIF2B4 -2630
EIF4G1 -3271
EIF2B1 -3781
EIF4H -4704
PABPC1 -4951
EIF3C -6235
EIF3B -6335
EIF3A -6487


Diseases associated with glycosaminoglycan metabolism

Diseases associated with glycosaminoglycan metabolism
305
set Diseases associated with glycosaminoglycan metabolism
setSize 36
pANOVA 1.13e-07
s.dist 0.511
p.adjustANOVA 3.26e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHST6 9665
PAPSS2 9649
HEXA 9623
OGN 9620
ACAN 9563
FMOD 9435
BGN 9356
GPC1 9219
DCN 9167
SLC26A2 8880
SDC2 8868
LUM 8806
CSPG4 8751
PRELP 8648
CHST3 8343
GPC6 8149
EXT1 7983
HSPG2 7413
OMD 7289
B4GALT1 7016

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHST6 9665
PAPSS2 9649
HEXA 9623
OGN 9620
ACAN 9563
FMOD 9435
BGN 9356
GPC1 9219
DCN 9167
SLC26A2 8880
SDC2 8868
LUM 8806
CSPG4 8751
PRELP 8648
CHST3 8343
GPC6 8149
EXT1 7983
HSPG2 7413
OMD 7289
B4GALT1 7016
SDC4 6636
HEXB 6123
EXT2 5442
CHST14 5275
AGRN 3453
GPC4 2588
B3GALT6 2165
B3GAT3 1916
ST3GAL3 743
SDC1 143
B4GALT7 108
GPC2 -485
VCAN -719
SDC3 -3366
CHSY1 -3675
GPC3 -5277


CD22 mediated BCR regulation

CD22 mediated BCR regulation
127
set CD22 mediated BCR regulation
setSize 12
pANOVA 0.00288
s.dist -0.497
p.adjustANOVA 0.0197



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHD -7518
IGLC3 -7027
IGHM -6099
PTPN6 -6042
CD22 -4355
IGLC2 -2741
IGLC1 -2634
CD79B -2034
CD79A -1982
LYN -1151
IGKC 378
IGLC7 1653

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHD -7518
IGLC3 -7027
IGHM -6099
PTPN6 -6042
CD22 -4355
IGLC2 -2741
IGLC1 -2634
CD79B -2034
CD79A -1982
LYN -1151
IGKC 378
IGLC7 1653


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
424
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 9.87e-10
s.dist 0.495
p.adjustANOVA 3.46e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
EIF3G 9208
RPS26 8270
RPS27 8063
EIF3E 8036
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
EIF3I 7766
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
RPS23 6945

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
EIF3G 9208
RPS26 8270
RPS27 8063
EIF3E 8036
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
EIF3I 7766
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
RPS23 6945
RPS9 6881
RPS5 6852
RPS27A 6798
RPS11 6786
EIF3H 6755
RPS20 6550
RPS4X 6478
RPS10 6378
RPS12 6252
RPS28 6220
RPS29 5883
RPS3 5459
RPS25 5401
EIF2S2 5073
EIF2S1 4953
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPS2 3554
EIF3D 2504
RPS16 1728
RPS4Y1 89
EIF2S3 -2159
EIF3C -6235
EIF3B -6335
EIF3A -6487


ZBP1(DAI) mediated induction of type I IFNs

ZBP1(DAI) mediated induction of type I IFNs
1439
set ZBP1(DAI) mediated induction of type I IFNs
setSize 20
pANOVA 0.000185
s.dist -0.483
p.adjustANOVA 0.00227



Top enriched genes

Top 20 genes
GeneID Gene Rank
IKBKB -6286
MYD88 -6202
NFKB1 -6141
RIPK3 -5397
NFKB2 -5158
NFKBIB -4880
IKBKG -4693
ZBP1 -4548
NFKBIA -4538
TICAM1 -4504
TLR3 -4371
RIPK1 -4322
NKIRAS2 -3779
IRF3 -3040
DHX9 -2931
DTX4 -1169
RELA -415
CHUK -344
NKIRAS1 1355
TBK1 7933

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IKBKB -6286
MYD88 -6202
NFKB1 -6141
RIPK3 -5397
NFKB2 -5158
NFKBIB -4880
IKBKG -4693
ZBP1 -4548
NFKBIA -4538
TICAM1 -4504
TLR3 -4371
RIPK1 -4322
NKIRAS2 -3779
IRF3 -3040
DHX9 -2931
DTX4 -1169
RELA -415
CHUK -344
NKIRAS1 1355
TBK1 7933


Scavenging by Class A Receptors

Scavenging by Class A Receptors
1141
set Scavenging by Class A Receptors
setSize 16
pANOVA 0.000881
s.dist 0.48
p.adjustANOVA 0.00827



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL1A1 9334
COL3A1 9256
COL1A2 9227
SCARA5 7789
FTL 7706
MASP1 7596
COL4A1 7489
COLEC12 7254
COL4A2 7172
HSP90B1 7078
MSR1 4827
FTH1 2530
APOE 2111
MARCO 1580
CALR -731
APOB -7050

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 9334
COL3A1 9256
COL1A2 9227
SCARA5 7789
FTL 7706
MASP1 7596
COL4A1 7489
COLEC12 7254
COL4A2 7172
HSP90B1 7078
MSR1 4827
FTH1 2530
APOE 2111
MARCO 1580
CALR -731
APOB -7050


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1269
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 17
pANOVA 0.000734
s.dist -0.473
p.adjustANOVA 0.00731



Top enriched genes

Top 20 genes
GeneID Gene Rank
DPEP1 -7244
DPEP3 -6902
ALOX15 -6227
DPEP2 -5872
ALOX5 -5283
CYP4F2 -5272
LTC4S -5120
GGT1 -5109
MAPKAPK2 -4717
CYP4F3 -3362
ABCC1 -2890
ALOX5AP -2723
LTA4H -1843
PTGR1 -1170
CYP4B1 747
GGT5 3327
CYP4A22 7184

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DPEP1 -7244
DPEP3 -6902
ALOX15 -6227
DPEP2 -5872
ALOX5 -5283
CYP4F2 -5272
LTC4S -5120
GGT1 -5109
MAPKAPK2 -4717
CYP4F3 -3362
ABCC1 -2890
ALOX5AP -2723
LTA4H -1843
PTGR1 -1170
CYP4B1 747
GGT5 3327
CYP4A22 7184


STAT5 activation downstream of FLT3 ITD mutants

STAT5 activation downstream of FLT3 ITD mutants
1126
set STAT5 activation downstream of FLT3 ITD mutants
setSize 10
pANOVA 0.00965
s.dist -0.473
p.adjustANOVA 0.0506



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT5A -7611
STAT5B -7538
GAB2 -6870
PIM1 -6684
FLT3 -6174
GRB2 -5320
BCL2L1 -4560
PTPN11 1140
CDKN1A 5074
NOX4 7687

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT5A -7611
STAT5B -7538
GAB2 -6870
PIM1 -6684
FLT3 -6174
GRB2 -5320
BCL2L1 -4560
PTPN11 1140
CDKN1A 5074
NOX4 7687


SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
1105
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 1.36e-08
s.dist 0.469
p.adjustANOVA 4.35e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS26 8270
RPS27 8063
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
SNRPD2 7448
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
GEMIN2 7024
RPS23 6945
RPS9 6881
RPS5 6852

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS26 8270
RPS27 8063
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
SNRPD2 7448
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
GEMIN2 7024
RPS23 6945
RPS9 6881
RPS5 6852
RPS27A 6798
RPS11 6786
RPS20 6550
RPS4X 6478
SNRPE 6447
RPS10 6378
RPS12 6252
RPS28 6220
RPS29 5883
RPS3 5459
RPS25 5401
SNRPD1 5164
RPSA 4938
RPS21 4818
RPS14 4721
GEMIN7 4634
SNRPF 3988
GEMIN6 3959
DDX20 3698
RPS2 3554
SNRPG 3373
RPS16 1728
GEMIN5 1655
RPS4Y1 89
SNRPD3 -913
SNRPB -1272
GEMIN8 -1572
SMN1 -4283
GEMIN4 -7271


ECM proteoglycans

ECM proteoglycans
339
set ECM proteoglycans
setSize 50
pANOVA 1.04e-08
s.dist 0.468
p.adjustANOVA 3.39e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL9A1 9705
HAPLN1 9653
ACAN 9563
TGFB2 9535
FMOD 9435
BGN 9356
COL9A3 9330
SERPINE1 9233
DCN 9167
COMP 9109
SPARC 9073
MATN3 9016
IBSP 8997
TNR 8833
LUM 8806
TGFB3 8481
LAMA1 8367
TNN 8327
MATN4 8037
ASPN 8008

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL9A1 9705
HAPLN1 9653
ACAN 9563
TGFB2 9535
FMOD 9435
BGN 9356
COL9A3 9330
SERPINE1 9233
DCN 9167
COMP 9109
SPARC 9073
MATN3 9016
IBSP 8997
TNR 8833
LUM 8806
TGFB3 8481
LAMA1 8367
TNN 8327
MATN4 8037
ASPN 8008
LAMA2 7878
LRP4 7700
ITGA2 7484
HSPG2 7413
LAMB2 6970
TNXB 6938
ITGAV 6713
TNC 6615
COL9A2 5791
ITGB5 5666
LAMC1 5119
DMP1 3999
NCAM1 3907
ITGB1 3814
LAMB1 3770
AGRN 3453
LAMA5 3416
ITGA9 2420
PTPRS 2038
DAG1 1722
LAMA4 1446
LAMA3 191
TGFB1 -201
VCAN -719
ITGB3 -2549
ITGA8 -3377
MATN1 -4796
ITGA7 -4885
ITGAX -6528
ITGA2B -7291


Regulation of IFNA/IFNB signaling

Regulation of IFNA/IFNB signaling
1028
set Regulation of IFNA/IFNB signaling
setSize 12
pANOVA 0.00523
s.dist -0.466
p.adjustANOVA 0.0318



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT2 -7322
SOCS1 -7279
PTPN6 -6042
TYK2 -6037
JAK1 -6017
STAT1 -5948
PTPN1 -4530
USP18 -4507
PTPN11 1140
SOCS3 2042
IFNAR2 3498
IFNAR1 4719

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT2 -7322
SOCS1 -7279
PTPN6 -6042
TYK2 -6037
JAK1 -6017
STAT1 -5948
PTPN1 -4530
USP18 -4507
PTPN11 1140
SOCS3 2042
IFNAR2 3498
IFNAR1 4719


Growth hormone receptor signaling

Growth hormone receptor signaling
501
set Growth hormone receptor signaling
setSize 20
pANOVA 0.000348
s.dist -0.462
p.adjustANOVA 0.00371



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRS2 -7645
STAT5A -7611
STAT5B -7538
CISH -7383
SOCS1 -7279
PTPN6 -6042
MAPK1 -6023
STAT1 -5948
PTPN1 -4530
GHR -4487
SH2B1 -2752
MAPK3 -1725
STAT3 -1313
LYN -1151
PRLR -729
SOCS2 447
ADAM17 1739
SOCS3 2042
JAK2 2661
IRS1 5455

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 -7645
STAT5A -7611
STAT5B -7538
CISH -7383
SOCS1 -7279
PTPN6 -6042
MAPK1 -6023
STAT1 -5948
PTPN1 -4530
GHR -4487
SH2B1 -2752
MAPK3 -1725
STAT3 -1313
LYN -1151
PRLR -729
SOCS2 447
ADAM17 1739
SOCS3 2042
JAK2 2661
IRS1 5455


GP1b-IX-V activation signalling

GP1b-IX-V activation signalling
454
set GP1b-IX-V activation signalling
setSize 10
pANOVA 0.0118
s.dist -0.46
p.adjustANOVA 0.0584



Top enriched genes

Top 20 genes
GeneID Gene Rank
GP1BA -7591
GP5 -7542
GP1BB -7362
GP9 -5619
FLNA -4022
RAF1 -3868
VWF -938
YWHAZ 1059
PIK3R1 1073
SRC 5053

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP1BA -7591
GP5 -7542
GP1BB -7362
GP9 -5619
FLNA -4022
RAF1 -3868
VWF -938
YWHAZ 1059
PIK3R1 1073
SRC 5053


Activation of the pre-replicative complex

Activation of the pre-replicative complex
52
set Activation of the pre-replicative complex
setSize 32
pANOVA 7.42e-06
s.dist -0.458
p.adjustANOVA 0.000144



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLE -7403
MCM5 -7363
MCM7 -7222
MCM3 -7208
POLA2 -7014
MCM4 -6917
RPA1 -6816
MCM2 -6804
CDT1 -6580
CDK2 -6521
MCM10 -5637
MCM6 -5167
ORC1 -5152
CDC6 -5114
MCM8 -4757
ORC2 -4503
CDC45 -4240
RPA2 -4130
POLA1 -2942
CDC7 -2539

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLE -7403
MCM5 -7363
MCM7 -7222
MCM3 -7208
POLA2 -7014
MCM4 -6917
RPA1 -6816
MCM2 -6804
CDT1 -6580
CDK2 -6521
MCM10 -5637
MCM6 -5167
ORC1 -5152
CDC6 -5114
MCM8 -4757
ORC2 -4503
CDC45 -4240
RPA2 -4130
POLA1 -2942
CDC7 -2539
PRIM2 -599
GMNN 286
ORC3 541
POLE4 578
PRIM1 595
POLE3 845
DBF4 925
POLE2 1110
ORC4 1748
ORC6 2204
RPA3 3664
ORC5 7718


Transcription of E2F targets under negative control by DREAM complex

Transcription of E2F targets under negative control by DREAM complex
1355
set Transcription of E2F targets under negative control by DREAM complex
setSize 19
pANOVA 0.000565
s.dist -0.457
p.adjustANOVA 0.00582



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYC -7472
E2F1 -7063
E2F4 -6479
CDC25A -6353
MAX -5697
HDAC1 -5500
CDC6 -5114
TFDP2 -4410
TFDP1 -3953
RBBP4 -3695
RBL2 -3032
PCNA -2049
LIN52 -1636
RBL1 -1518
TOP2A -1442
LIN37 -713
LIN54 -102
LIN9 2163
E2F5 8085

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYC -7472
E2F1 -7063
E2F4 -6479
CDC25A -6353
MAX -5697
HDAC1 -5500
CDC6 -5114
TFDP2 -4410
TFDP1 -3953
RBBP4 -3695
RBL2 -3032
PCNA -2049
LIN52 -1636
RBL1 -1518
TOP2A -1442
LIN37 -713
LIN54 -102
LIN9 2163
E2F5 8085


Inhibition of replication initiation of damaged DNA by RB1/E2F1

Inhibition of replication initiation of damaged DNA by RB1/E2F1
566
set Inhibition of replication initiation of damaged DNA by RB1/E2F1
setSize 13
pANOVA 0.00493
s.dist -0.45
p.adjustANOVA 0.0304



Top enriched genes

Top 20 genes
GeneID Gene Rank
PPP2R1B -7531
E2F1 -7063
POLA2 -7014
PPP2R3B -6539
TFDP2 -4410
TFDP1 -3953
POLA1 -2942
RB1 -1850
PRIM2 -599
PPP2R1A -366
PRIM1 595
PPP2CA 774
PPP2CB 3312

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PPP2R1B -7531
E2F1 -7063
POLA2 -7014
PPP2R3B -6539
TFDP2 -4410
TFDP1 -3953
POLA1 -2942
RB1 -1850
PRIM2 -599
PPP2R1A -366
PRIM1 595
PPP2CA 774
PPP2CB 3312


G0 and Early G1

G0 and Early G1
441
set G0 and Early G1
setSize 27
pANOVA 5.25e-05
s.dist -0.45
p.adjustANOVA 0.000806



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYC -7472
E2F1 -7063
CDK2 -6521
MYBL2 -6511
E2F4 -6479
CDC25A -6353
MAX -5697
CCNE1 -5598
HDAC1 -5500
CDC6 -5114
TFDP2 -4410
TFDP1 -3953
DYRK1A -3907
RBBP4 -3695
RBL2 -3032
PCNA -2049
LIN52 -1636
RBL1 -1518
TOP2A -1442
CCNA2 -770

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYC -7472
E2F1 -7063
CDK2 -6521
MYBL2 -6511
E2F4 -6479
CDC25A -6353
MAX -5697
CCNE1 -5598
HDAC1 -5500
CDC6 -5114
TFDP2 -4410
TFDP1 -3953
DYRK1A -3907
RBBP4 -3695
RBL2 -3032
PCNA -2049
LIN52 -1636
RBL1 -1518
TOP2A -1442
CCNA2 -770
LIN37 -713
CCNE2 -694
LIN54 -102
CDK1 -36
LIN9 2163
CCNA1 2218
E2F5 8085


Heme biosynthesis

Heme biosynthesis
525
set Heme biosynthesis
setSize 13
pANOVA 0.00513
s.dist -0.448
p.adjustANOVA 0.0313



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALAD -7278
PPOX -6736
CPOX -5781
COX15 -5372
ALAS2 -5226
ALAS1 -5200
UROS -4641
FECH -4289
HMBS -3825
UROD -3756
ABCG2 -2426
FLVCR1 8093
COX10 9083

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALAD -7278
PPOX -6736
CPOX -5781
COX15 -5372
ALAS2 -5226
ALAS1 -5200
UROS -4641
FECH -4289
HMBS -3825
UROD -3756
ABCG2 -2426
FLVCR1 8093
COX10 9083


Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
321
set Dissolution of Fibrin Clot
setSize 12
pANOVA 0.0073
s.dist 0.447
p.adjustANOVA 0.0412



Top enriched genes

Top 20 genes
GeneID Gene Rank
SERPINE1 9233
S100A10 8802
PLG 7707
SERPINB6 6951
SERPINE2 6869
ANXA2 5638
PLAUR 5486
SERPINF2 3079
SERPINB8 3051
SERPINB2 2660
PLAU 2007
PLAT -2533

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SERPINE1 9233
S100A10 8802
PLG 7707
SERPINB6 6951
SERPINE2 6869
ANXA2 5638
PLAUR 5486
SERPINF2 3079
SERPINB8 3051
SERPINB2 2660
PLAU 2007
PLAT -2533


Interleukin-3, Interleukin-5 and GM-CSF signaling

Interleukin-3, Interleukin-5 and GM-CSF signaling
599
set Interleukin-3, Interleukin-5 and GM-CSF signaling
setSize 40
pANOVA 9.98e-07
s.dist -0.447
p.adjustANOVA 2.41e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAT5A -7611
CSF2RA -7578
STAT5B -7538
IL3RA -7230
CBL -7098
INPP5D -7048
GAB2 -6870
VAV1 -6759
BLNK -6701
CSF2RB -6229
PTPN6 -6042
JAK1 -6017
PIK3R2 -5832
IL2RG -5447
GRB2 -5320
CRKL -4687
SYK -4606
RAPGEF1 -4544
HCK -4468
JAK3 -4424

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAT5A -7611
CSF2RA -7578
STAT5B -7538
IL3RA -7230
CBL -7098
INPP5D -7048
GAB2 -6870
VAV1 -6759
BLNK -6701
CSF2RB -6229
PTPN6 -6042
JAK1 -6017
PIK3R2 -5832
IL2RG -5447
GRB2 -5320
CRKL -4687
SYK -4606
RAPGEF1 -4544
HCK -4468
JAK3 -4424
SOS1 -4390
PRKACA -4272
PIK3CB -1501
LYN -1151
IL2RB -998
TEC -884
INPPL1 -858
PIK3CD -499
SHC1 -450
FYN -103
IL2RA 737
YWHAZ 1059
PIK3R1 1073
PTPN11 1140
CRK 1826
PIK3R3 1874
IL5RA 1881
JAK2 2661
PIK3CA 3740
YES1 6944


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1092
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 4.3e-09
s.dist 0.446
p.adjustANOVA 1.44e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3J 9578
EIF3G 9208
RPS26 8270
RPS27 8063
EIF3E 8036
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
EIF3I 7766
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
EIF4A2 6958

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3J 9578
EIF3G 9208
RPS26 8270
RPS27 8063
EIF3E 8036
RPS24 7991
RPS17 7867
RPS18 7844
FAU 7793
EIF3I 7766
RPS3A 7761
RPS15A 7699
RPS13 7522
RPS8 7511
RPS27L 7374
RPS19 7317
RPS15 7272
RPS7 7252
RPS6 7118
EIF4A2 6958
RPS23 6945
RPS9 6881
RPS5 6852
RPS27A 6798
RPS11 6786
EIF3H 6755
EIF4E 6570
RPS20 6550
RPS4X 6478
RPS10 6378
RPS12 6252
RPS28 6220
RPS29 5883
RPS3 5459
RPS25 5401
EIF2S2 5073
EIF2S1 4953
RPSA 4938
EIF3M 4875
RPS21 4818
EIF3F 4775
RPS14 4721
EIF5 4486
EIF4A1 4374
EIF3K 3833
EIF1AX 3823
EIF3L 3665
RPS2 3554
EIF3D 2504
RPS16 1728
RPS4Y1 89
EIF4B -1877
EIF2S3 -2159
EIF4G1 -3271
EIF4H -4704
EIF3C -6235
EIF3B -6335
EIF3A -6487


Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation
1024
set Regulation of FOXO transcriptional activity by acetylation
setSize 10
pANOVA 0.0148
s.dist -0.445
p.adjustANOVA 0.0678



Top enriched genes

Top 20 genes
GeneID Gene Rank
EP300 -6823
FOXO4 -6355
TXNIP -6169
CREBBP -5646
FOXO3 -4929
SIRT1 -4155
SIRT3 -3775
KAT2B -3114
TXN 6153
FOXO1 6346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EP300 -6823
FOXO4 -6355
TXNIP -6169
CREBBP -5646
FOXO3 -4929
SIRT1 -4155
SIRT3 -3775
KAT2B -3114
TXN 6153
FOXO1 6346


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
787
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 2.45e-16
s.dist 0.444
p.adjustANOVA 1.57e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL17 9371
RPL3L 9214
RPL9 9124
RPL26L1 8820
RPL26 8722
RPL21 8594
RPL13A 8446
RPL18A 8274
RPS26 8270
RPL31 8265
RPL35 8123
RPS27 8063
RPL10 8039
RPS24 7991
RPL41 7964
RPS17 7867
RPS18 7844
RPL29 7831
RPL23A 7819
FAU 7793
RPS3A 7761
RPL15 7744
RPL34 7708
RPS15A 7699
RPL35A 7689
RPL36 7589
RPL24 7586
RPS13 7522
RPS8 7511
RPLP0 7432
RPS27L 7374
RPL4 7347
RPS19 7317
RPL39L 7286
RPL30 7282
RPS15 7272
RPL37 7262
RPS7 7252
RPL27A 7200
RPL32 7177
UBA52 7168
RPS6 7118
RPL7A 7009
RPL39 6999
RPL14 6971
RPS23 6945
RPL18 6891
RPS9 6881
RPS5 6852
RPL12 6820
RPL7 6800
RPS27A 6798
RPS11 6786
RPLP1 6753
RPL27 6738
RPS20 6550
RPL10A 6541
RPL19 6520
RPL13 6490
RPL22L1 6487
RPL37A 6479
RPS4X 6478
RPL23 6411
RPL5 6408
RPS10 6378
RPL11 6277
RPS12 6252
RPS28 6220
RPL6 6178
RPL36AL 6056
MAGOHB 5949
RPS29 5883
RPL3 5673
RPL22 5559
RPL8 5554
RPS3 5459
RPS25 5401
RPLP2 5338
RPL28 5311
UPF2 5024
RPSA 4938
NCBP1 4894
RPS21 4818
RPS14 4721
UPF3A 4020
RPL36A 3933
NCBP2 3872
RPL38 3656
RPS2 3554
RPS16 1728
MAGOH 1389
ETF1 1341
GSPT2 1304
UPF3B 1271
PNRC2 1087
PPP2CA 774
RPS4Y1 89
PPP2R1A -366
RBM8A -411
SMG8 -754
SMG1 -2248
PPP2R2A -2384
CASC3 -3199
EIF4G1 -3271
SMG9 -3872
SMG5 -4120
DCP1A -4132
GSPT1 -4195
UPF1 -4676
EIF4A3 -4702
PABPC1 -4951
SMG6 -5590
RNPS1 -6481
SMG7 -7360


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.1               GGally_2.1.2               
##  [3] beeswarm_0.4.0              gtools_3.9.3               
##  [5] echarts4r_0.4.4             kableExtra_1.3.4           
##  [7] topconfects_1.12.0          limma_3.52.2               
##  [9] eulerr_6.1.1                mitch_1.8.0                
## [11] MASS_7.3-58.1               fgsea_1.22.0               
## [13] gplots_3.1.3                DESeq2_1.36.0              
## [15] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [17] MatrixGenerics_1.8.1        matrixStats_0.62.0         
## [19] GenomicRanges_1.48.0        GenomeInfoDb_1.32.2        
## [21] IRanges_2.30.0              S4Vectors_0.34.0           
## [23] BiocGenerics_0.42.0         reshape2_1.4.4             
## [25] forcats_0.5.2               stringr_1.4.1              
## [27] dplyr_1.0.10                purrr_0.3.5                
## [29] readr_2.1.3                 tidyr_1.2.1                
## [31] tibble_3.1.8                ggplot2_3.3.6              
## [33] tidyverse_1.3.2             zoo_1.8-11                 
## [35] R.utils_2.12.0              R.oo_1.25.0                
## [37] R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.4.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.4      plyr_1.8.7             splines_4.2.1         
##   [7] BiocParallel_1.30.3    digest_0.6.30          htmltools_0.5.3       
##  [10] fansi_1.0.3            magrittr_2.0.3         memoise_2.0.1         
##  [13] googlesheets4_1.0.1    tzdb_0.3.0             Biostrings_2.64.0     
##  [16] annotate_1.74.0        modelr_0.1.9           svglite_2.1.0         
##  [19] colorspace_2.0-3       blob_1.2.3             rvest_1.0.3           
##  [22] haven_2.5.1            xfun_0.34              crayon_1.5.2          
##  [25] RCurl_1.98-1.9         jsonlite_1.8.3         genefilter_1.78.0     
##  [28] survival_3.4-0         glue_1.6.2             gtable_0.3.1          
##  [31] gargle_1.2.1           zlibbioc_1.42.0        XVector_0.36.0        
##  [34] webshot_0.5.4          DelayedArray_0.22.0    scales_1.2.1          
##  [37] DBI_1.1.3              Rcpp_1.0.9             viridisLite_0.4.1     
##  [40] xtable_1.8-4           bit_4.0.4              htmlwidgets_1.5.4     
##  [43] httr_1.4.4             RColorBrewer_1.1-3     ellipsis_0.3.2        
##  [46] pkgconfig_2.0.3        reshape_0.8.9          XML_3.99-0.12         
##  [49] sass_0.4.2             dbplyr_2.2.1           locfit_1.5-9.6        
##  [52] utf8_1.2.2             tidyselect_1.2.0       rlang_1.0.6           
##  [55] later_1.3.0            AnnotationDbi_1.58.0   munsell_0.5.0         
##  [58] cellranger_1.1.0       tools_4.2.1            cachem_1.0.6          
##  [61] cli_3.4.1              generics_0.1.3         RSQLite_2.2.18        
##  [64] broom_1.0.1            evaluate_0.17          fastmap_1.1.0         
##  [67] yaml_2.3.6             knitr_1.40             bit64_4.0.5           
##  [70] fs_1.5.2               caTools_1.18.2         KEGGREST_1.36.3       
##  [73] mime_0.12              xml2_1.3.3             compiler_4.2.1        
##  [76] rstudioapi_0.14        png_0.1-7              reprex_2.0.2          
##  [79] geneplotter_1.74.0     bslib_0.4.0            stringi_1.7.8         
##  [82] highr_0.9              lattice_0.20-45        Matrix_1.5-1          
##  [85] vctrs_0.5.0            pillar_1.8.1           lifecycle_1.0.3       
##  [88] jquerylib_0.1.4        data.table_1.14.4      bitops_1.0-7          
##  [91] httpuv_1.6.6           R6_2.5.1               promises_1.2.0.1      
##  [94] KernSmooth_2.23-20     gridExtra_2.3          codetools_0.2-18      
##  [97] assertthat_0.2.1       withr_2.5.0            GenomeInfoDbData_1.2.8
## [100] parallel_4.2.1         hms_1.1.2              grid_4.2.1            
## [103] rmarkdown_2.17         googledrive_2.0.0      shiny_1.7.3           
## [106] lubridate_1.8.0

END of report