Mitch Report

date generated: 2023-09-01

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-0.3313712
7SK	1.0562551
A1BG	1.9763385
A1BG.AS1	-0.2735674
A2M	0.6882405
A2M.AS1	0.0013723

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2612
num_genes_in_profile	18354
duplicated_genes_present	0
num_profile_genes_in_sets	8748
num_profile_genes_not_in_sets	9606

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2612
num_genesets_excluded	1116
num_genesets_included	1496

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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set	setSize	pANOVA	s.dist	p.adjustANOVA
Unwinding of DNA	12	2.76e-05	-0.699	3.27e-04
Crosslinking of collagen fibrils	17	5.81e-06	0.635	8.96e-05
Polo-like kinase mediated events	16	2.51e-05	-0.608	3.02e-04
Eukaryotic Translation Elongation	93	1.43e-23	0.600	1.07e-20
Interleukin-2 signaling	11	6.25e-04	-0.596	4.65e-03
Viral mRNA Translation	88	4.56e-22	0.595	1.05e-19
Peptide chain elongation	88	4.92e-22	0.595	1.05e-19
Synthesis of Leukotrienes (LT) and Eoxins (EX)	16	3.90e-05	-0.594	4.38e-04
RIP-mediated NFkB activation via ZBP1	17	2.49e-05	-0.590	3.02e-04
Collagen biosynthesis and modifying enzymes	63	1.02e-15	0.584	6.94e-14
MET activates PTK2 signaling	29	5.57e-08	0.583	1.39e-06
Interleukin-15 signaling	14	1.99e-04	-0.574	1.76e-03
Heme biosynthesis	13	3.40e-04	-0.574	2.72e-03
Presynaptic depolarization and calcium channel opening	10	1.78e-03	0.570	1.07e-02
Anchoring fibril formation	13	4.82e-04	0.559	3.66e-03
Eukaryotic Translation Termination	92	9.22e-20	0.548	1.06e-17
HDMs demethylate histones	21	1.45e-05	-0.546	2.00e-04
Selenocysteine synthesis	92	1.54e-19	0.545	1.64e-17
Collagen chain trimerization	40	2.69e-09	0.544	9.32e-08
Formation of a pool of free 40S subunits	100	8.41e-21	0.541	1.40e-18
SRP-dependent cotranslational protein targeting to membrane	111	1.08e-22	0.538	5.38e-20
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	3.35e-19	0.534	3.13e-17
SARS-CoV-1 modulates host translation machinery	36	3.03e-08	0.533	7.96e-07
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	1.64e-19	0.523	1.64e-17
Transcription of E2F targets under negative control by DREAM complex	19	8.05e-05	-0.522	7.93e-04
G0 and Early G1	27	2.76e-06	-0.521	4.80e-05
Collagen formation	83	5.03e-16	0.515	3.58e-14
ECM proteoglycans	66	4.70e-13	0.515	2.51e-11
Assembly of collagen fibrils and other multimeric structures	55	6.18e-11	0.510	2.64e-09
GTP hydrolysis and joining of the 60S ribosomal subunit	111	5.65e-20	0.502	7.04e-18
ZBP1(DAI) mediated induction of type I IFNs	20	1.04e-04	-0.501	9.95e-04
CS/DS degradation	11	3.99e-03	0.501	2.06e-02
CD22 mediated BCR regulation	12	2.69e-03	-0.500	1.51e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	3.80e-04	-0.498	2.98e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	3.80e-04	-0.498	2.98e-03
Regulation of FOXO transcriptional activity by acetylation	10	6.65e-03	-0.496	3.02e-02
L13a-mediated translational silencing of Ceruloplasmin expression	110	5.31e-19	0.491	4.67e-17
Interleukin receptor SHC signaling	23	4.62e-05	-0.491	4.98e-04
Growth hormone receptor signaling	20	1.59e-04	-0.488	1.45e-03
STAT5 activation downstream of FLT3 ITD mutants	10	7.62e-03	-0.487	3.35e-02
G1/S-Specific Transcription	29	6.08e-06	-0.485	9.28e-05
Metabolism of porphyrins	21	1.42e-04	-0.480	1.32e-03
FOXO-mediated transcription of cell death genes	16	9.03e-04	-0.479	6.28e-03
Activation of the pre-replicative complex	32	2.94e-06	-0.477	5.06e-05
DNA strand elongation	32	3.01e-06	-0.477	5.08e-05
Selenoamino acid metabolism	114	1.41e-18	0.477	1.17e-16
Regulation of TP53 Activity through Acetylation	29	9.28e-06	-0.476	1.35e-04
NCAM1 interactions	33	2.45e-06	0.474	4.31e-05
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	7.75e-04	-0.471	5.57e-03
Diseases associated with glycosaminoglycan metabolism	36	1.17e-06	0.468	2.30e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Unwinding of DNA	12	2.76e-05	-0.699000	3.27e-04
Crosslinking of collagen fibrils	17	5.81e-06	0.635000	8.96e-05
Polo-like kinase mediated events	16	2.51e-05	-0.608000	3.02e-04
Eukaryotic Translation Elongation	93	1.43e-23	0.600000	1.07e-20
Interleukin-2 signaling	11	6.25e-04	-0.596000	4.65e-03
Viral mRNA Translation	88	4.56e-22	0.595000	1.05e-19
Peptide chain elongation	88	4.92e-22	0.595000	1.05e-19
Synthesis of Leukotrienes (LT) and Eoxins (EX)	16	3.90e-05	-0.594000	4.38e-04
RIP-mediated NFkB activation via ZBP1	17	2.49e-05	-0.590000	3.02e-04
Collagen biosynthesis and modifying enzymes	63	1.02e-15	0.584000	6.94e-14
MET activates PTK2 signaling	29	5.57e-08	0.583000	1.39e-06
Interleukin-15 signaling	14	1.99e-04	-0.574000	1.76e-03
Heme biosynthesis	13	3.40e-04	-0.574000	2.72e-03
Presynaptic depolarization and calcium channel opening	10	1.78e-03	0.570000	1.07e-02
Anchoring fibril formation	13	4.82e-04	0.559000	3.66e-03
Eukaryotic Translation Termination	92	9.22e-20	0.548000	1.06e-17
HDMs demethylate histones	21	1.45e-05	-0.546000	2.00e-04
Selenocysteine synthesis	92	1.54e-19	0.545000	1.64e-17
Collagen chain trimerization	40	2.69e-09	0.544000	9.32e-08
Formation of a pool of free 40S subunits	100	8.41e-21	0.541000	1.40e-18
SRP-dependent cotranslational protein targeting to membrane	111	1.08e-22	0.538000	5.38e-20
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	3.35e-19	0.534000	3.13e-17
SARS-CoV-1 modulates host translation machinery	36	3.03e-08	0.533000	7.96e-07
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	1.64e-19	0.523000	1.64e-17
Transcription of E2F targets under negative control by DREAM complex	19	8.05e-05	-0.522000	7.93e-04
G0 and Early G1	27	2.76e-06	-0.521000	4.80e-05
Collagen formation	83	5.03e-16	0.515000	3.58e-14
ECM proteoglycans	66	4.70e-13	0.515000	2.51e-11
Assembly of collagen fibrils and other multimeric structures	55	6.18e-11	0.510000	2.64e-09
GTP hydrolysis and joining of the 60S ribosomal subunit	111	5.65e-20	0.502000	7.04e-18
ZBP1(DAI) mediated induction of type I IFNs	20	1.04e-04	-0.501000	9.95e-04
CS/DS degradation	11	3.99e-03	0.501000	2.06e-02
CD22 mediated BCR regulation	12	2.69e-03	-0.500000	1.51e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	3.80e-04	-0.498000	2.98e-03
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	3.80e-04	-0.498000	2.98e-03
Regulation of FOXO transcriptional activity by acetylation	10	6.65e-03	-0.496000	3.02e-02
L13a-mediated translational silencing of Ceruloplasmin expression	110	5.31e-19	0.491000	4.67e-17
Interleukin receptor SHC signaling	23	4.62e-05	-0.491000	4.98e-04
Growth hormone receptor signaling	20	1.59e-04	-0.488000	1.45e-03
STAT5 activation downstream of FLT3 ITD mutants	10	7.62e-03	-0.487000	3.35e-02
G1/S-Specific Transcription	29	6.08e-06	-0.485000	9.28e-05
Metabolism of porphyrins	21	1.42e-04	-0.480000	1.32e-03
FOXO-mediated transcription of cell death genes	16	9.03e-04	-0.479000	6.28e-03
Activation of the pre-replicative complex	32	2.94e-06	-0.477000	5.06e-05
DNA strand elongation	32	3.01e-06	-0.477000	5.08e-05
Selenoamino acid metabolism	114	1.41e-18	0.477000	1.17e-16
Regulation of TP53 Activity through Acetylation	29	9.28e-06	-0.476000	1.35e-04
NCAM1 interactions	33	2.45e-06	0.474000	4.31e-05
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	7.75e-04	-0.471000	5.57e-03
Diseases associated with glycosaminoglycan metabolism	36	1.17e-06	0.468000	2.30e-05
Signaling by Erythropoietin	24	7.30e-05	-0.468000	7.28e-04
Expression and translocation of olfactory receptors	30	9.37e-06	0.467000	1.35e-04
Transcriptional regulation of granulopoiesis	42	1.73e-07	-0.466000	3.92e-06
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	7.57e-03	-0.465000	3.35e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	8.16e-03	-0.461000	3.48e-02
Cap-dependent Translation Initiation	118	6.27e-18	0.460000	4.69e-16
Eukaryotic Translation Initiation	118	6.27e-18	0.460000	4.69e-16
Regulation of IFNA/IFNB signaling	12	5.91e-03	-0.459000	2.76e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	9.11e-03	-0.454000	3.78e-02
FGFR2 ligand binding and activation	10	1.36e-02	0.451000	5.12e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	2.02e-03	-0.446000	1.18e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	13	5.44e-03	-0.445000	2.58e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	5.50e-03	-0.445000	2.59e-02
Maturation of nucleoprotein 9683610	11	1.08e-02	-0.444000	4.25e-02
Interleukin-2 family signaling	37	3.06e-06	-0.443000	5.08e-05
Erythropoietin activates RAS	13	5.99e-03	-0.440000	2.79e-02
Scavenging by Class A Receptors	16	2.33e-03	0.440000	1.34e-02
Pyrimidine salvage	10	1.69e-02	-0.436000	6.11e-02
Condensation of Prometaphase Chromosomes	11	1.23e-02	-0.436000	4.72e-02
Formation of the ternary complex, and subsequently, the 43S complex	51	9.52e-08	0.432000	2.26e-06
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.01e-02	-0.429000	4.06e-02
alpha-linolenic acid (ALA) metabolism	12	1.01e-02	-0.429000	4.06e-02
RUNX3 regulates NOTCH signaling	14	5.69e-03	-0.427000	2.67e-02
Collagen degradation	55	4.42e-08	0.427000	1.14e-06
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	48	3.18e-07	-0.426000	6.90e-06
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	6.32e-03	-0.421000	2.93e-02
Non-integrin membrane-ECM interactions	55	9.12e-08	0.416000	2.20e-06
Interleukin-3, Interleukin-5 and GM-CSF signaling	44	1.79e-06	-0.416000	3.34e-05
Striated Muscle Contraction	32	4.70e-05	0.416000	5.02e-04
Olfactory Signaling Pathway	35	2.22e-05	0.414000	2.79e-04
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	37	1.38e-05	-0.413000	1.92e-04
Syndecan interactions	26	2.84e-04	0.411000	2.33e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.38e-02	-0.410000	5.17e-02
Interleukin-20 family signaling	14	9.23e-03	-0.402000	3.80e-02
Beta-oxidation of very long chain fatty acids	10	2.89e-02	-0.399000	9.33e-02
SARS-CoV-2 modulates host translation machinery	49	1.39e-06	0.398000	2.67e-05
Condensation of Prophase Chromosomes	25	6.12e-04	-0.396000	4.58e-03
STAT3 nuclear events downstream of ALK signaling	10	3.02e-02	-0.396000	9.69e-02
Phase 0 - rapid depolarisation	26	4.86e-04	0.395000	3.67e-03
MET promotes cell motility	39	2.25e-05	0.392000	2.81e-04
TRAF6 mediated NF-kB activation	23	1.19e-03	-0.390000	7.73e-03
Eicosanoid ligand-binding receptors	14	1.15e-02	-0.390000	4.44e-02
Interferon alpha/beta signaling	57	3.57e-07	-0.390000	7.53e-06
RORA activates gene expression	18	4.23e-03	-0.389000	2.18e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.17e-02	-0.389000	4.51e-02
RNA Polymerase I Promoter Opening	15	9.27e-03	-0.388000	3.81e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	7.22e-03	0.388000	3.22e-02
Ribosomal scanning and start codon recognition	58	3.36e-07	0.387000	7.17e-06
Phase 4 - resting membrane potential	10	3.41e-02	0.387000	1.05e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	9.73e-13	0.387000	4.85e-11
Nonsense-Mediated Decay (NMD)	114	9.73e-13	0.387000	4.85e-11
Laminin interactions	28	4.25e-04	0.385000	3.29e-03
TRAF3-dependent IRF activation pathway	13	1.65e-02	-0.384000	5.98e-02
Defective B4GALT7 causes EDS, progeroid type	16	7.94e-03	0.383000	3.45e-02
PKMTs methylate histone lysines	42	1.79e-05	-0.383000	2.39e-04
Activation of ATR in response to replication stress	37	6.33e-05	-0.380000	6.49e-04
DNA methylation	16	8.84e-03	-0.378000	3.73e-02
Mismatch Repair	15	1.14e-02	-0.378000	4.41e-02
Pentose phosphate pathway	13	1.86e-02	-0.377000	6.53e-02
Defective B3GAT3 causes JDSSDHD	16	9.03e-03	0.377000	3.75e-02
Processive synthesis on the lagging strand	15	1.15e-02	-0.377000	4.44e-02
Keratan sulfate degradation	12	2.41e-02	0.376000	8.12e-02
Zinc transporters	11	3.12e-02	0.375000	9.93e-02
Cellular response to starvation	150	2.64e-15	0.374000	1.64e-13
Interleukin-6 signaling	11	3.22e-02	-0.373000	1.01e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	2.53e-02	-0.373000	8.50e-02
Diseases of hemostasis	12	2.53e-02	-0.373000	8.50e-02
eNOS activation	11	3.23e-02	0.373000	1.01e-01
Glutathione synthesis and recycling	10	4.22e-02	-0.371000	1.24e-01
Translation initiation complex formation	58	1.22e-06	0.368000	2.36e-05
HDR through MMEJ (alt-NHEJ)	12	2.80e-02	-0.366000	9.20e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	1.76e-02	-0.366000	6.32e-02
PRC2 methylates histones and DNA	25	1.52e-03	-0.366000	9.30e-03
MAPK3 (ERK1) activation	10	4.51e-02	-0.366000	1.30e-01
RHO GTPases Activate NADPH Oxidases	21	3.74e-03	-0.365000	1.98e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	2.27e-02	0.365000	7.80e-02
Defective EXT2 causes exostoses 2	13	2.27e-02	0.365000	7.80e-02
Depolymerization of the Nuclear Lamina	15	1.45e-02	-0.365000	5.36e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.78e-06	0.360000	3.34e-05
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	28	1.01e-03	-0.359000	6.83e-03
Signaling by Leptin	11	4.01e-02	-0.357000	1.20e-01
NR1H2 and NR1H3-mediated signaling	41	7.58e-05	-0.357000	7.51e-04
Complex I biogenesis	51	1.02e-05	0.357000	1.46e-04
Diseases associated with the TLR signaling cascade	28	1.27e-03	-0.352000	8.09e-03
Diseases of Immune System	28	1.27e-03	-0.352000	8.09e-03
Dissolution of Fibrin Clot	12	3.51e-02	0.351000	1.08e-01
SUMOylation of DNA replication proteins	46	4.09e-05	-0.350000	4.53e-04
A tetrasaccharide linker sequence is required for GAG synthesis	22	4.67e-03	0.348000	2.36e-02
Elastic fibre formation	40	1.38e-04	0.348000	1.29e-03
E2F mediated regulation of DNA replication	22	4.93e-03	-0.346000	2.44e-02
Lagging Strand Synthesis	20	7.90e-03	-0.343000	3.45e-02
Regulation of expression of SLITs and ROBOs	163	4.57e-14	0.342000	2.74e-12
Defective pyroptosis	25	3.21e-03	-0.340000	1.76e-02
Interleukin-7 signaling	21	7.05e-03	-0.340000	3.16e-02
TP53 Regulates Transcription of Cell Cycle Genes	47	6.14e-05	-0.338000	6.42e-04
BBSome-mediated cargo-targeting to cilium	21	7.62e-03	0.336000	3.35e-02
Unblocking of NMDA receptors, glutamate binding and activation	21	7.69e-03	0.336000	3.37e-02
DNA Damage/Telomere Stress Induced Senescence	40	2.37e-04	-0.336000	1.98e-03
Long-term potentiation	23	5.33e-03	0.336000	2.57e-02
Processive synthesis on the C-strand of the telomere	19	1.18e-02	-0.334000	4.54e-02
Removal of the Flap Intermediate	14	3.07e-02	-0.334000	9.82e-02
Defective B3GALTL causes PpS	34	7.98e-04	0.332000	5.69e-03
Influenza Viral RNA Transcription and Replication	135	3.10e-11	0.331000	1.41e-09
Generation of second messenger molecules	24	5.16e-03	-0.330000	2.53e-02
Cyclin A/B1/B2 associated events during G2/M transition	25	4.40e-03	-0.329000	2.25e-02
Formation of ATP by chemiosmotic coupling	16	2.29e-02	0.329000	7.80e-02
O-glycosylation of TSR domain-containing proteins	35	7.98e-04	0.328000	5.69e-03
Nuclear Pore Complex (NPC) Disassembly	36	6.89e-04	-0.327000	5.03e-03
RAF-independent MAPK1/3 activation	22	8.00e-03	-0.327000	3.46e-02
Nuclear Envelope Breakdown	53	4.45e-05	-0.324000	4.86e-04
Molecules associated with elastic fibres	33	1.27e-03	0.324000	8.09e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	18	1.73e-02	-0.324000	6.23e-02
Telomere C-strand (Lagging Strand) Synthesis	34	1.12e-03	-0.323000	7.29e-03
Regulation of MECP2 expression and activity	30	2.22e-03	-0.323000	1.28e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	34	1.17e-03	-0.322000	7.63e-03
CASP8 activity is inhibited	11	6.57e-02	-0.320000	1.69e-01
Dimerization of procaspase-8	11	6.57e-02	-0.320000	1.69e-01
Regulation by c-FLIP	11	6.57e-02	-0.320000	1.69e-01
STING mediated induction of host immune responses	15	3.19e-02	-0.320000	1.01e-01
FLT3 Signaling	38	6.55e-04	-0.319000	4.83e-03
Pre-NOTCH Transcription and Translation	45	2.19e-04	-0.318000	1.90e-03
Receptor-type tyrosine-protein phosphatases	15	3.28e-02	0.318000	1.02e-01
Translation	292	1.20e-20	0.317000	1.63e-18
NOTCH2 intracellular domain regulates transcription	11	6.94e-02	-0.316000	1.75e-01
TRAF6 mediated IRF7 activation	15	3.43e-02	-0.316000	1.05e-01
Formation of WDR5-containing histone-modifying complexes	42	4.02e-04	-0.316000	3.13e-03
Metabolism of steroid hormones	22	1.05e-02	0.315000	4.15e-02
Synthesis of IP3 and IP4 in the cytosol	24	7.59e-03	-0.315000	3.35e-02
SARS-CoV-2 modulates autophagy	11	7.11e-02	-0.314000	1.79e-01
Chondroitin sulfate/dermatan sulfate metabolism	45	2.77e-04	0.313000	2.29e-03
Role of LAT2/NTAL/LAB on calcium mobilization	22	1.12e-02	-0.312000	4.38e-02
Signaling by high-kinase activity BRAF mutants	33	1.96e-03	-0.311000	1.16e-02
Transcriptional regulation of white adipocyte differentiation	84	1.03e-06	-0.308000	2.07e-05
Meiotic synapsis	38	1.00e-03	-0.308000	6.83e-03
Other interleukin signaling	22	1.23e-02	-0.308000	4.72e-02
Regulation of IFNG signaling	13	5.45e-02	-0.308000	1.49e-01
Oxidative Stress Induced Senescence	75	4.11e-06	-0.308000	6.58e-05
Interferon gamma signaling	75	4.30e-06	-0.307000	6.77e-05
Triglyceride metabolism	24	9.49e-03	-0.306000	3.88e-02
Early Phase of HIV Life Cycle	14	4.83e-02	-0.305000	1.36e-01
WNT5A-dependent internalization of FZD4	14	4.90e-02	-0.304000	1.37e-01
Signaling by cytosolic FGFR1 fusion mutants	18	2.56e-02	-0.304000	8.56e-02
ERBB2 Activates PTK6 Signaling	12	6.87e-02	0.304000	1.74e-01
Signaling by FLT3 ITD and TKD mutants	16	3.56e-02	-0.303000	1.09e-01
Phosphorylation of CD3 and TCR zeta chains	13	5.97e-02	-0.302000	1.60e-01
Initiation of Nuclear Envelope (NE) Reformation	19	2.28e-02	-0.302000	7.80e-02
Interleukin-35 Signalling	11	8.36e-02	-0.301000	2.00e-01
Paracetamol ADME	19	2.31e-02	-0.301000	7.84e-02
Acyl chain remodelling of PI	12	7.09e-02	0.301000	1.79e-01
Interleukin-27 signaling	10	1.00e-01	-0.300000	2.27e-01
Chromatin modifying enzymes	212	5.09e-14	-0.300000	2.82e-12
Chromatin organization	212	5.09e-14	-0.300000	2.82e-12
Respiratory electron transport	93	5.79e-07	0.300000	1.19e-05
Activation of gene expression by SREBF (SREBP)	42	7.75e-04	-0.300000	5.57e-03
Extension of Telomeres	50	2.54e-04	-0.299000	2.11e-03
Removal of the Flap Intermediate from the C-strand	17	3.28e-02	-0.299000	1.02e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	3.50e-03	-0.298000	1.88e-02
RUNX3 regulates p14-ARF	10	1.03e-01	-0.298000	2.31e-01
ERKs are inactivated	13	6.32e-02	-0.298000	1.66e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	4.88e-03	-0.297000	2.43e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	4.88e-03	-0.297000	2.43e-02
Resolution of D-Loop Structures	34	2.80e-03	-0.296000	1.56e-02
Chondroitin sulfate biosynthesis	16	4.03e-02	0.296000	1.20e-01
PD-1 signaling	14	5.54e-02	-0.296000	1.50e-01
Rev-mediated nuclear export of HIV RNA	35	2.48e-03	-0.296000	1.40e-02
Vpr-mediated nuclear import of PICs	34	2.92e-03	-0.295000	1.62e-02
PCNA-Dependent Long Patch Base Excision Repair	21	1.94e-02	-0.295000	6.80e-02
SUMOylation of ubiquitinylation proteins	39	1.47e-03	-0.294000	9.02e-03
WNT ligand biogenesis and trafficking	20	2.29e-02	0.294000	7.80e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	1.10e-02	-0.294000	4.33e-02
Regulation of signaling by CBL	22	1.71e-02	-0.294000	6.17e-02
Beta-catenin phosphorylation cascade	17	3.68e-02	-0.292000	1.12e-01
Signal regulatory protein family interactions	12	7.96e-02	-0.292000	1.93e-01
Oncogene Induced Senescence	33	3.82e-03	-0.291000	1.99e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	33	3.90e-03	-0.290000	2.02e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	1.03e-07	0.290000	2.41e-06
Scavenging of heme from plasma	15	5.27e-02	-0.289000	1.45e-01
Packaging Of Telomere Ends	18	3.39e-02	-0.289000	1.05e-01
Deposition of new CENPA-containing nucleosomes at the centromere	38	2.08e-03	-0.289000	1.21e-02
Nucleosome assembly	38	2.08e-03	-0.289000	1.21e-02
Disorders of Developmental Biology	13	7.20e-02	-0.288000	1.79e-01
Disorders of Nervous System Development	13	7.20e-02	-0.288000	1.79e-01
Loss of function of MECP2 in Rett syndrome	13	7.20e-02	-0.288000	1.79e-01
Pervasive developmental disorders	13	7.20e-02	-0.288000	1.79e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	1.15e-01	0.288000	2.50e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	8.44e-02	-0.288000	2.02e-01
Mitotic Telophase/Cytokinesis	13	7.34e-02	-0.287000	1.81e-01
APC truncation mutants have impaired AXIN binding	14	6.36e-02	-0.286000	1.66e-01
AXIN missense mutants destabilize the destruction complex	14	6.36e-02	-0.286000	1.66e-01
Signaling by AMER1 mutants	14	6.36e-02	-0.286000	1.66e-01
Signaling by APC mutants	14	6.36e-02	-0.286000	1.66e-01
Signaling by AXIN mutants	14	6.36e-02	-0.286000	1.66e-01
Truncations of AMER1 destabilize the destruction complex	14	6.36e-02	-0.286000	1.66e-01
Major pathway of rRNA processing in the nucleolus and cytosol	180	3.63e-11	0.286000	1.60e-09
FCERI mediated MAPK activation	38	2.35e-03	-0.285000	1.34e-02
AKT phosphorylates targets in the nucleus	10	1.19e-01	-0.285000	2.56e-01
Extracellular matrix organization	264	1.69e-15	0.285000	1.10e-13
MASTL Facilitates Mitotic Progression	10	1.20e-01	-0.284000	2.57e-01
Meiosis	59	1.62e-04	-0.284000	1.47e-03
Nitric oxide stimulates guanylate cyclase	19	3.22e-02	0.284000	1.01e-01
Cleavage of the damaged purine	22	2.14e-02	-0.283000	7.42e-02
Depurination	22	2.14e-02	-0.283000	7.42e-02
Recognition and association of DNA glycosylase with site containing an affected purine	22	2.14e-02	-0.283000	7.42e-02
Signaling by CSF1 (M-CSF) in myeloid cells	31	6.39e-03	-0.283000	2.95e-02
Biosynthesis of specialized proresolving mediators (SPMs)	17	4.34e-02	-0.283000	1.26e-01
Metal ion SLC transporters	20	2.87e-02	0.283000	9.31e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	3.39e-03	-0.282000	1.83e-02
Mitotic Prophase	94	2.31e-06	-0.282000	4.11e-05
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.42e-03	-0.281000	8.83e-03
Amino acid transport across the plasma membrane	23	1.97e-02	-0.281000	6.89e-02
Export of Viral Ribonucleoproteins from Nucleus	33	5.27e-03	-0.281000	2.57e-02
NEP/NS2 Interacts with the Cellular Export Machinery	32	6.01e-03	-0.281000	2.79e-02
NS1 Mediated Effects on Host Pathways	40	2.20e-03	-0.280000	1.28e-02
Influenza Infection	154	2.11e-09	0.280000	7.69e-08
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	8.98e-05	-0.279000	8.72e-04
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	9.57e-02	-0.278000	2.21e-01
Diseases of programmed cell death	56	3.33e-04	-0.277000	2.69e-03
Synthesis of PIPs at the Golgi membrane	15	6.39e-02	-0.276000	1.66e-01
Polymerase switching on the C-strand of the telomere	26	1.47e-02	-0.276000	5.43e-02
Inwardly rectifying K+ channels	26	1.49e-02	0.276000	5.48e-02
Meiotic recombination	34	5.40e-03	-0.276000	2.57e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes	15	6.45e-02	-0.276000	1.67e-01
Keratan sulfate biosynthesis	26	1.51e-02	0.275000	5.52e-02
Interactions of Rev with host cellular proteins	37	3.75e-03	-0.275000	1.98e-02
RMTs methylate histone arginines	35	4.89e-03	-0.275000	2.43e-02
Elevation of cytosolic Ca2+ levels	13	8.80e-02	-0.273000	2.08e-01
ABC transporters in lipid homeostasis	14	7.67e-02	-0.273000	1.88e-01
Frs2-mediated activation	12	1.02e-01	-0.273000	2.29e-01
Maturation of nucleoprotein 9694631	15	6.74e-02	-0.273000	1.73e-01
TAK1-dependent IKK and NF-kappa-B activation	43	1.98e-03	-0.273000	1.17e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	4.69e-03	-0.272000	2.36e-02
Myogenesis	23	2.40e-02	0.272000	8.12e-02
Transport of Mature mRNA Derived from an Intronless Transcript	42	2.39e-03	-0.271000	1.36e-02
Signaling by ROBO receptors	206	2.33e-11	0.270000	1.09e-09
Translocation of ZAP-70 to Immunological synapse	10	1.40e-01	-0.270000	2.82e-01
DCC mediated attractive signaling	13	9.24e-02	0.270000	2.16e-01
Platelet sensitization by LDL	17	5.47e-02	-0.269000	1.49e-01
Transcriptional Regulation by E2F6	34	6.63e-03	-0.269000	3.02e-02
Cytosolic iron-sulfur cluster assembly	13	9.30e-02	-0.269000	2.16e-01
Erythrocytes take up carbon dioxide and release oxygen	12	1.07e-01	-0.269000	2.36e-01
O2/CO2 exchange in erythrocytes	12	1.07e-01	-0.269000	2.36e-01
Processing of Intronless Pre-mRNAs	20	3.82e-02	-0.268000	1.15e-01
Transport of Mature Transcript to Cytoplasm	81	3.12e-05	-0.268000	3.54e-04
Cellular Senescence	139	5.13e-08	-0.268000	1.30e-06
rRNA processing in the nucleus and cytosol	190	2.05e-10	0.268000	8.30e-09
MAP2K and MAPK activation	37	5.26e-03	-0.265000	2.57e-02
Formation of the beta-catenin:TCF transactivating complex	42	2.96e-03	-0.265000	1.63e-02
Costimulation by the CD28 family	58	4.82e-04	-0.265000	3.66e-03
Activation of BH3-only proteins	29	1.37e-02	-0.264000	5.14e-02
SUMOylation	167	3.83e-09	-0.264000	1.27e-07
Nuclear import of Rev protein	34	7.88e-03	-0.263000	3.45e-02
SUMO E3 ligases SUMOylate target proteins	161	8.65e-09	-0.263000	2.70e-07
Diseases of mitotic cell cycle	38	5.16e-03	-0.262000	2.53e-02
RNA Polymerase I Transcription Termination	30	1.31e-02	0.262000	4.97e-02
Ion homeostasis	48	1.71e-03	0.262000	1.04e-02
Biosynthesis of DHA-derived SPMs	15	7.97e-02	-0.261000	1.93e-01
Assembly of the ORC complex at the origin of replication	21	3.85e-02	-0.261000	1.16e-01
Regulation of TP53 Activity	154	2.38e-08	-0.261000	6.60e-07
mRNA 3’-end processing	57	6.66e-04	-0.261000	4.89e-03
Mitochondrial translation initiation	88	2.51e-05	0.260000	3.02e-04
Platelet Aggregation (Plug Formation)	34	8.80e-03	-0.260000	3.72e-02
DNA Double-Strand Break Repair	138	1.42e-07	-0.260000	3.27e-06
Termination of translesion DNA synthesis	31	1.24e-02	-0.260000	4.73e-02
IRF3-mediated induction of type I IFN	12	1.20e-01	-0.259000	2.58e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.47e-04	-0.259000	1.35e-03
EML4 and NUDC in mitotic spindle formation	107	3.84e-06	-0.259000	6.24e-05
Integrin signaling	24	2.84e-02	-0.259000	9.29e-02
Neutrophil degranulation	456	3.33e-21	-0.258000	6.22e-19
GP1b-IX-V activation signalling	12	1.22e-01	-0.258000	2.60e-01
Nucleotide biosynthesis	12	1.22e-01	-0.258000	2.60e-01
Prolactin receptor signaling	11	1.38e-01	-0.258000	2.81e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	2.33e-02	-0.257000	7.91e-02
Base Excision Repair	57	8.07e-04	-0.257000	5.72e-03
Activation of the AP-1 family of transcription factors	10	1.60e-01	-0.256000	3.13e-01
Inflammasomes	21	4.20e-02	-0.256000	1.24e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	92	2.17e-05	-0.256000	2.75e-04
Amplification of signal from the kinetochores	92	2.17e-05	-0.256000	2.75e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	95	1.61e-05	0.256000	2.19e-04
CD28 dependent Vav1 pathway	11	1.42e-01	-0.256000	2.85e-01
Signaling by PDGFRA extracellular domain mutants	12	1.26e-01	-0.255000	2.64e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	1.26e-01	-0.255000	2.64e-01
Cargo concentration in the ER	31	1.40e-02	0.255000	5.19e-02
Fanconi Anemia Pathway	36	8.13e-03	-0.255000	3.48e-02
Transport of the SLBP Dependant Mature mRNA	36	8.14e-03	-0.255000	3.48e-02
SUMOylation of SUMOylation proteins	35	9.14e-03	-0.255000	3.78e-02
GPVI-mediated activation cascade	34	1.02e-02	-0.255000	4.09e-02
Signaling by RAF1 mutants	38	6.65e-03	-0.254000	3.02e-02
Prolonged ERK activation events	14	9.94e-02	-0.254000	2.26e-01
Synthesis of PE	12	1.28e-01	-0.254000	2.68e-01
Mitochondrial translation	94	2.16e-05	0.254000	2.75e-04
Interferon Signaling	167	1.69e-08	-0.253000	4.86e-07
Leading Strand Synthesis	14	1.01e-01	-0.253000	2.29e-01
Polymerase switching	14	1.01e-01	-0.253000	2.29e-01
HCMV Early Events	83	6.95e-05	-0.253000	7.02e-04
Mitochondrial translation termination	88	4.26e-05	0.252000	4.69e-04
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	7.98e-03	-0.252000	3.46e-02
Activation of G protein gated Potassium channels	21	4.59e-02	0.252000	1.31e-01
G protein gated Potassium channels	21	4.59e-02	0.252000	1.31e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	21	4.59e-02	0.252000	1.31e-01
Regulation of NF-kappa B signaling	18	6.47e-02	-0.251000	1.68e-01
Telomere Extension By Telomerase	22	4.12e-02	-0.251000	1.21e-01
Degradation of the extracellular matrix	116	3.04e-06	0.251000	5.08e-05
CD28 co-stimulation	32	1.41e-02	-0.251000	5.23e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.33e-01	-0.250000	2.73e-01
Repression of WNT target genes	14	1.05e-01	-0.250000	2.35e-01
Translation of Structural Proteins 9683701	29	2.01e-02	-0.249000	7.01e-02
HATs acetylate histones	91	4.00e-05	-0.249000	4.46e-04
Cell recruitment (pro-inflammatory response)	25	3.15e-02	-0.249000	9.97e-02
Purinergic signaling in leishmaniasis infection	25	3.15e-02	-0.249000	9.97e-02
RUNX2 regulates bone development	30	1.85e-02	0.248000	6.53e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF	42	5.37e-03	-0.248000	2.57e-02
Signaling by RAS mutants	42	5.37e-03	-0.248000	2.57e-02
Signaling by moderate kinase activity BRAF mutants	42	5.37e-03	-0.248000	2.57e-02
Signaling downstream of RAS mutants	42	5.37e-03	-0.248000	2.57e-02
HDACs deacetylate histones	44	4.39e-03	-0.248000	2.25e-02
Signaling by SCF-KIT	42	5.41e-03	-0.248000	2.57e-02
Mitochondrial translation elongation	88	6.24e-05	0.247000	6.47e-04
Post-translational protein phosphorylation	83	1.05e-04	0.246000	9.97e-04
AURKA Activation by TPX2	71	3.34e-04	-0.246000	2.69e-03
Regulation of KIT signaling	16	8.81e-02	-0.246000	2.08e-01
Regulation of TP53 Expression and Degradation	37	9.80e-03	-0.245000	3.98e-02
rRNA processing	200	2.26e-09	0.245000	8.04e-08
Mitotic Prometaphase	193	4.35e-09	-0.245000	1.42e-07
Cristae formation	29	2.24e-02	0.245000	7.73e-02
Cell Cycle, Mitotic	499	9.39e-21	-0.245000	1.40e-18
NOTCH3 Intracellular Domain Regulates Transcription	23	4.27e-02	-0.244000	1.25e-01
Nucleotide salvage	22	4.83e-02	-0.243000	1.36e-01
Negative regulation of FLT3	15	1.04e-01	-0.242000	2.33e-01
Transport of the SLBP independent Mature mRNA	35	1.33e-02	-0.242000	5.04e-02
Reproduction	78	2.25e-04	-0.242000	1.94e-03
Trafficking and processing of endosomal TLR	13	1.32e-01	-0.241000	2.73e-01
Resolution of Sister Chromatid Cohesion	116	7.17e-06	-0.241000	1.07e-04
Telomere C-strand synthesis initiation	13	1.33e-01	-0.241000	2.73e-01
Acetylcholine regulates insulin secretion	10	1.89e-01	-0.240000	3.55e-01
Mitotic G1 phase and G1/S transition	148	4.77e-07	-0.240000	9.91e-06
Homology Directed Repair	108	1.67e-05	-0.240000	2.25e-04
TBC/RABGAPs	45	5.38e-03	-0.240000	2.57e-02
Cytosolic sensors of pathogen-associated DNA	63	1.02e-03	-0.239000	6.85e-03
SUMOylation of chromatin organization proteins	57	1.78e-03	-0.239000	1.07e-02
LGI-ADAM interactions	11	1.69e-01	0.239000	3.27e-01
CD28 dependent PI3K/Akt signaling	21	5.80e-02	-0.239000	1.56e-01
Regulation of TP53 Degradation	36	1.32e-02	-0.239000	4.99e-02
SARS-CoV-1 activates/modulates innate immune responses	39	9.95e-03	-0.239000	4.04e-02
Chaperone Mediated Autophagy	20	6.49e-02	0.238000	1.68e-01
Signaling by BMP	24	4.34e-02	0.238000	1.26e-01
Regulation of PTEN gene transcription	60	1.45e-03	-0.238000	8.95e-03
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	23	4.87e-02	-0.237000	1.36e-01
Reduction of cytosolic Ca++ levels	10	1.94e-01	0.237000	3.63e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	1.12e-01	0.237000	2.46e-01
Diseases associated with O-glycosylation of proteins	55	2.44e-03	0.236000	1.38e-02
HCMV Infection	107	2.57e-05	-0.236000	3.07e-04
Surfactant metabolism	17	9.30e-02	-0.235000	2.16e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	8.46e-02	-0.235000	2.02e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	11	1.78e-01	0.235000	3.39e-01
FOXO-mediated transcription	58	2.02e-03	-0.234000	1.18e-02
Resolution of Abasic Sites (AP sites)	38	1.25e-02	-0.234000	4.75e-02
Notch-HLH transcription pathway	28	3.21e-02	-0.234000	1.01e-01
RHOU GTPase cycle	40	1.05e-02	-0.234000	4.15e-02
Chromosome Maintenance	101	4.96e-05	-0.234000	5.26e-04
Ovarian tumor domain proteases	35	1.69e-02	-0.233000	6.11e-02
RNA Polymerase II Transcription Termination	66	1.05e-03	-0.233000	6.98e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	3.11e-05	-0.232000	3.54e-04
Toll Like Receptor 2 (TLR2) Cascade	108	3.11e-05	-0.232000	3.54e-04
Toll Like Receptor TLR1:TLR2 Cascade	108	3.11e-05	-0.232000	3.54e-04
Toll Like Receptor TLR6:TLR2 Cascade	108	3.11e-05	-0.232000	3.54e-04
HCMV Late Events	68	9.39e-04	-0.232000	6.51e-03
MyD88 deficiency (TLR2/4)	14	1.34e-01	-0.231000	2.75e-01
Aflatoxin activation and detoxification	14	1.34e-01	-0.231000	2.75e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	101	6.27e-05	-0.231000	6.47e-04
Synthesis of pyrophosphates in the cytosol	10	2.07e-01	-0.230000	3.76e-01
Diseases of glycosylation	125	8.97e-06	0.230000	1.32e-04
Loss of Nlp from mitotic centrosomes	68	1.04e-03	-0.230000	6.91e-03
Loss of proteins required for interphase microtubule organization from the centrosome	68	1.04e-03	-0.230000	6.91e-03
DNA Damage Bypass	46	6.97e-03	-0.230000	3.13e-02
Centrosome maturation	80	3.78e-04	-0.230000	2.98e-03
Recruitment of mitotic centrosome proteins and complexes	80	3.78e-04	-0.230000	2.98e-03
PINK1-PRKN Mediated Mitophagy	21	6.84e-02	0.230000	1.74e-01
Cell Cycle	614	3.22e-22	-0.229000	1.05e-19
Biotin transport and metabolism	11	1.88e-01	-0.229000	3.55e-01
The role of Nef in HIV-1 replication and disease pathogenesis	26	4.31e-02	-0.229000	1.26e-01
Antiviral mechanism by IFN-stimulated genes	79	4.44e-04	-0.229000	3.42e-03
SUMOylation of immune response proteins	11	1.90e-01	-0.228000	3.58e-01
FGFR2 mutant receptor activation	24	5.31e-02	0.228000	1.45e-01
Toll Like Receptor 4 (TLR4) Cascade	137	4.41e-06	-0.227000	6.88e-05
Activation of Matrix Metalloproteinases	26	4.51e-02	0.227000	1.30e-01
Aspartate and asparagine metabolism	10	2.14e-01	0.227000	3.85e-01
Regulation of PTEN mRNA translation	12	1.74e-01	-0.226000	3.35e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	102	8.18e-05	-0.226000	8.00e-04
Translesion Synthesis by POLH	18	9.78e-02	-0.225000	2.24e-01
TNFR1-induced NF-kappa-B signaling pathway	33	2.54e-02	-0.225000	8.52e-02
MyD88 dependent cascade initiated on endosome	101	9.72e-05	-0.224000	9.38e-04
CTNNB1 S33 mutants aren’t phosphorylated	15	1.33e-01	-0.224000	2.73e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	1.33e-01	-0.224000	2.73e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	1.33e-01	-0.224000	2.73e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	1.33e-01	-0.224000	2.73e-01
Signaling by CTNNB1 phospho-site mutants	15	1.33e-01	-0.224000	2.73e-01
Signaling by GSK3beta mutants	15	1.33e-01	-0.224000	2.73e-01
RUNX2 regulates osteoblast differentiation	23	6.31e-02	0.224000	1.66e-01
NCAM signaling for neurite out-growth	54	4.47e-03	0.224000	2.27e-02
Cardiac conduction	99	1.26e-04	0.223000	1.19e-03
Signaling by PDGFR in disease	20	8.48e-02	-0.223000	2.02e-01
Signaling by CSF3 (G-CSF)	29	3.80e-02	-0.223000	1.15e-01
Telomere Maintenance	76	8.99e-04	-0.220000	6.28e-03
Cyclin D associated events in G1	47	9.02e-03	-0.220000	3.75e-02
G1 Phase	47	9.02e-03	-0.220000	3.75e-02
Mitotic Spindle Checkpoint	109	7.27e-05	-0.220000	7.28e-04
Negative regulators of DDX58/IFIH1 signaling	34	2.65e-02	-0.220000	8.79e-02
Negative regulation of NMDA receptor-mediated neuronal transmission	20	8.89e-02	0.220000	2.10e-01
SIRT1 negatively regulates rRNA expression	20	8.98e-02	-0.219000	2.11e-01
Toll-like Receptor Cascades	159	1.93e-06	-0.219000	3.56e-05
Transport of vitamins, nucleosides, and related molecules	32	3.22e-02	0.219000	1.01e-01
Transcriptional regulation by small RNAs	59	3.68e-03	-0.219000	1.95e-02
Killing mechanisms	10	2.32e-01	-0.218000	4.08e-01
WNT5:FZD7-mediated leishmania damping	10	2.32e-01	-0.218000	4.08e-01
MyD88 cascade initiated on plasma membrane	95	2.36e-04	-0.218000	1.98e-03
Toll Like Receptor 10 (TLR10) Cascade	95	2.36e-04	-0.218000	1.98e-03
Toll Like Receptor 5 (TLR5) Cascade	95	2.36e-04	-0.218000	1.98e-03
SUMOylation of RNA binding proteins	47	9.77e-03	-0.218000	3.98e-02
RHOH GTPase cycle	34	2.80e-02	-0.218000	9.20e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	1.72e-04	-0.217000	1.55e-03
RHO GTPases Activate Formins	130	1.88e-05	-0.217000	2.44e-04
Estrogen-dependent gene expression	99	1.88e-04	-0.217000	1.67e-03
activated TAK1 mediates p38 MAPK activation	23	7.17e-02	-0.217000	1.79e-01
Glucose metabolism	83	6.42e-04	-0.217000	4.76e-03
Recruitment of NuMA to mitotic centrosomes	87	4.79e-04	-0.217000	3.66e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	25	6.24e-02	-0.215000	1.65e-01
Regulation of innate immune responses to cytosolic DNA	14	1.64e-01	-0.215000	3.18e-01
Peroxisomal lipid metabolism	27	5.31e-02	-0.215000	1.45e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	102	1.78e-04	-0.215000	1.59e-03
Pre-NOTCH Expression and Processing	61	3.76e-03	-0.215000	1.98e-02
Negative regulation of MET activity	20	9.69e-02	-0.214000	2.23e-01
Signal transduction by L1	21	8.90e-02	-0.214000	2.10e-01
Toll Like Receptor 9 (TLR9) Cascade	105	1.55e-04	-0.214000	1.42e-03
Potential therapeutics for SARS	101	2.11e-04	-0.213000	1.84e-03
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	29	4.67e-02	-0.213000	1.33e-01
ISG15 antiviral mechanism	71	1.94e-03	-0.213000	1.16e-02
Germ layer formation at gastrulation	11	2.22e-01	0.213000	3.95e-01
Triglyceride catabolism	16	1.42e-01	-0.212000	2.85e-01
Signaling by WNT in cancer	30	4.46e-02	-0.212000	1.29e-01
mRNA Capping	29	4.85e-02	0.212000	1.36e-01
DAP12 interactions	35	3.02e-02	-0.212000	9.69e-02
G1/S Transition	130	3.10e-05	-0.212000	3.54e-04
SUMOylation of DNA methylation proteins	16	1.43e-01	-0.211000	2.87e-01
Interactions of Vpr with host cellular proteins	37	2.65e-02	-0.211000	8.79e-02
Caspase activation via Death Receptors in the presence of ligand	16	1.45e-01	-0.210000	2.89e-01
Epigenetic regulation of gene expression	139	1.86e-05	-0.210000	2.44e-04
Nuclear Envelope (NE) Reassembly	68	2.75e-03	-0.210000	1.54e-02
HDR through Homologous Recombination (HRR)	67	2.95e-03	-0.210000	1.63e-02
Muscle contraction	163	3.77e-06	0.210000	6.21e-05
Toll Like Receptor 3 (TLR3) Cascade	103	2.34e-04	-0.210000	1.98e-03
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	3.26e-02	-0.209000	1.01e-01
Cleavage of the damaged pyrimidine	27	6.05e-02	-0.209000	1.61e-01
Depyrimidination	27	6.05e-02	-0.209000	1.61e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	27	6.05e-02	-0.209000	1.61e-01
Folding of actin by CCT/TriC	10	2.58e-01	0.207000	4.41e-01
Signaling by NODAL	13	1.97e-01	-0.207000	3.64e-01
Pregnenolone biosynthesis	11	2.36e-01	0.206000	4.15e-01
Glycolysis	66	4.02e-03	-0.205000	2.07e-02
Degradation of cysteine and homocysteine	13	2.02e-01	-0.205000	3.70e-01
Factors involved in megakaryocyte development and platelet production	127	6.92e-05	-0.205000	7.02e-04
GABA receptor activation	41	2.35e-02	0.205000	7.95e-02
Regulation of beta-cell development	22	9.70e-02	-0.204000	2.23e-01
SUMOylation of DNA damage response and repair proteins	77	1.93e-03	-0.204000	1.16e-02
Initial triggering of complement	25	7.72e-02	-0.204000	1.88e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	8.90e-03	-0.204000	3.74e-02
Keratan sulfate/keratin metabolism	32	4.61e-02	0.204000	1.31e-01
Processing of Capped Intronless Pre-mRNA	29	5.87e-02	-0.203000	1.57e-01
SUMOylation of intracellular receptors	27	6.83e-02	-0.203000	1.74e-01
Inactivation of CSF3 (G-CSF) signaling	24	8.59e-02	-0.203000	2.04e-01
DNA Repair	292	2.74e-09	-0.202000	9.32e-08
CRMPs in Sema3A signaling	15	1.75e-01	0.202000	3.35e-01
Signaling by PDGF	55	9.45e-03	0.202000	3.87e-02
Regulation of TP53 Activity through Phosphorylation	89	9.78e-04	-0.202000	6.71e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	6.92e-02	-0.202000	1.75e-01
RHO GTPases activate PKNs	44	2.08e-02	-0.201000	7.25e-02
M Phase	356	7.44e-11	-0.201000	3.09e-09
RHO GTPase Effectors	259	3.03e-08	-0.200000	7.96e-07
Acyl chain remodelling of PG	13	2.12e-01	0.200000	3.83e-01
Carnitine metabolism	14	1.96e-01	-0.200000	3.63e-01
Processing of Capped Intron-Containing Pre-mRNA	279	1.06e-08	-0.199000	3.25e-07
Metalloprotease DUBs	21	1.14e-01	-0.199000	2.50e-01
Processing of DNA double-strand break ends	68	4.54e-03	-0.199000	2.30e-02
Postmitotic nuclear pore complex (NPC) reformation	27	7.41e-02	-0.199000	1.82e-01
Infection with Mycobacterium tuberculosis	27	7.46e-02	-0.198000	1.83e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	1.01e-01	0.198000	2.28e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	112	3.09e-04	-0.197000	2.52e-03
Diseases of DNA repair	51	1.50e-02	-0.197000	5.51e-02
ER Quality Control Compartment (ERQC)	21	1.19e-01	-0.197000	2.56e-01
Retrograde neurotrophin signalling	14	2.03e-01	-0.197000	3.71e-01
Signaling by BRAF and RAF1 fusions	60	8.75e-03	-0.196000	3.71e-02
Negative regulation of MAPK pathway	42	2.82e-02	-0.196000	9.26e-02
IRAK4 deficiency (TLR2/4)	15	1.90e-01	-0.196000	3.57e-01
RND2 GTPase cycle	38	3.69e-02	-0.196000	1.12e-01
Regulation of RUNX1 Expression and Activity	18	1.51e-01	-0.195000	2.96e-01
Downregulation of ERBB2 signaling	28	7.38e-02	0.195000	1.82e-01
TICAM1-dependent activation of IRF3/IRF7	12	2.43e-01	-0.195000	4.24e-01
Regulation of lipid metabolism by PPARalpha	106	5.46e-04	-0.194000	4.11e-03
The citric acid (TCA) cycle and respiratory electron transport	160	2.36e-05	0.194000	2.92e-04
Regulation of NPAS4 gene expression	12	2.45e-01	-0.194000	4.27e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	8.21e-02	0.193000	1.97e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	8.21e-02	0.193000	1.97e-01
AKT phosphorylates targets in the cytosol	14	2.11e-01	-0.193000	3.82e-01
Regulation of TP53 Activity through Methylation	19	1.46e-01	-0.193000	2.90e-01
Impaired BRCA2 binding to PALB2	24	1.02e-01	-0.193000	2.29e-01
RHO GTPases activate IQGAPs	24	1.04e-01	-0.192000	2.32e-01
Signaling by FGFR2 IIIa TM	19	1.48e-01	0.192000	2.93e-01
Phospholipid metabolism	185	6.95e-06	-0.192000	1.05e-04
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	2.00e-01	0.191000	3.68e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	2.00e-01	0.191000	3.68e-01
Endogenous sterols	19	1.50e-01	0.191000	2.95e-01
InlB-mediated entry of Listeria monocytogenes into host cell	14	2.17e-01	-0.191000	3.87e-01
PI Metabolism	78	3.64e-03	-0.190000	1.94e-02
Regulation of PLK1 Activity at G2/M Transition	86	2.32e-03	-0.190000	1.33e-02
Transcriptional regulation by RUNX1	180	1.10e-05	-0.190000	1.56e-04
Synthesis of PC	25	1.01e-01	-0.190000	2.29e-01
Cell Cycle Checkpoints	256	1.86e-07	-0.189000	4.15e-06
Rap1 signalling	15	2.04e-01	-0.189000	3.73e-01
Ras activation upon Ca2+ influx through NMDA receptor	20	1.43e-01	0.189000	2.87e-01
Innate Immune System	921	3.49e-22	-0.189000	1.05e-19
Inositol phosphate metabolism	45	2.85e-02	-0.189000	9.31e-02
CD209 (DC-SIGN) signaling	20	1.45e-01	-0.188000	2.90e-01
DNA Double Strand Break Response	49	2.28e-02	-0.188000	7.80e-02
Arachidonic acid metabolism	44	3.11e-02	-0.188000	9.92e-02
RHOF GTPase cycle	40	3.99e-02	-0.188000	1.19e-01
Establishment of Sister Chromatid Cohesion	11	2.81e-01	-0.188000	4.69e-01
mRNA Splicing - Major Pathway	203	4.14e-06	-0.188000	6.58e-05
Interleukin-10 signaling	36	5.18e-02	-0.187000	1.42e-01
Deadenylation of mRNA	22	1.29e-01	-0.187000	2.69e-01
Base-Excision Repair, AP Site Formation	29	8.15e-02	-0.187000	1.96e-01
Senescence-Associated Secretory Phenotype (SASP)	63	1.04e-02	-0.187000	4.13e-02
EPHA-mediated growth cone collapse	25	1.06e-01	0.187000	2.36e-01
Intrinsic Pathway for Apoptosis	54	1.77e-02	-0.187000	6.33e-02
Acyl chain remodelling of PS	17	1.84e-01	0.186000	3.49e-01
MyD88-independent TLR4 cascade	107	8.99e-04	-0.186000	6.28e-03
TRIF(TICAM1)-mediated TLR4 signaling	107	8.99e-04	-0.186000	6.28e-03
Signaling by KIT in disease	20	1.50e-01	-0.186000	2.95e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	1.50e-01	-0.186000	2.95e-01
PPARA activates gene expression	104	1.07e-03	-0.186000	7.05e-03
Calnexin/calreticulin cycle	26	1.02e-01	-0.185000	2.30e-01
Signaling by ALK	25	1.10e-01	-0.185000	2.42e-01
Recycling pathway of L1	40	4.33e-02	-0.185000	1.26e-01
Bacterial Infection Pathways	67	9.01e-03	-0.185000	3.75e-02
CLEC7A (Dectin-1) induces NFAT activation	11	2.89e-01	0.185000	4.78e-01
Metabolism of amino acids and derivatives	320	1.55e-08	0.184000	4.53e-07
DNA Replication	137	2.01e-04	-0.184000	1.77e-03
Homologous DNA Pairing and Strand Exchange	43	3.71e-02	-0.184000	1.12e-01
G2/M DNA damage checkpoint	64	1.11e-02	-0.184000	4.34e-02
Signaling by FLT3 fusion proteins	19	1.66e-01	-0.183000	3.21e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	19	1.66e-01	-0.183000	3.21e-01
Glycerophospholipid biosynthesis	108	1.04e-03	-0.183000	6.91e-03
Impaired BRCA2 binding to RAD51	35	6.26e-02	-0.182000	1.66e-01
Response of Mtb to phagocytosis	23	1.32e-01	-0.182000	2.73e-01
Transcriptional Regulation by TP53	347	6.74e-09	-0.181000	2.15e-07
Sealing of the nuclear envelope (NE) by ESCRT-III	24	1.24e-01	-0.181000	2.62e-01
Glycosaminoglycan metabolism	109	1.09e-03	0.181000	7.18e-03
Interleukin-17 signaling	67	1.07e-02	-0.180000	4.21e-02
Activation of BAD and translocation to mitochondria	14	2.43e-01	-0.180000	4.24e-01
Creation of C4 and C2 activators	17	1.99e-01	-0.180000	3.67e-01
Nuclear Receptor transcription pathway	40	4.89e-02	-0.180000	1.37e-01
Nicotinate metabolism	27	1.06e-01	-0.180000	2.35e-01
Cell-extracellular matrix interactions	18	1.87e-01	-0.180000	3.54e-01
FLT3 signaling in disease	28	1.01e-01	-0.179000	2.29e-01
Activation of SMO	17	2.02e-01	0.179000	3.71e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	48	3.22e-02	-0.179000	1.01e-01
Deubiquitination	237	2.22e-06	-0.179000	4.00e-05
mRNA Splicing	211	7.99e-06	-0.178000	1.18e-04
rRNA processing in the mitochondrion	10	3.29e-01	-0.178000	5.15e-01
Translesion synthesis by POLI	17	2.03e-01	-0.178000	3.72e-01
MAP kinase activation	63	1.45e-02	-0.178000	5.36e-02
Integrin cell surface interactions	77	6.94e-03	0.178000	3.13e-02
The NLRP3 inflammasome	16	2.20e-01	-0.177000	3.92e-01
Nonhomologous End-Joining (NHEJ)	39	5.58e-02	-0.177000	1.51e-01
Physiological factors	10	3.33e-01	-0.177000	5.20e-01
Cytosolic tRNA aminoacylation	24	1.35e-01	0.176000	2.76e-01
Immune System	1742	1.08e-33	-0.176000	1.62e-30
Presynaptic phase of homologous DNA pairing and strand exchange	40	5.50e-02	-0.175000	1.49e-01
S Phase	161	1.31e-04	-0.175000	1.24e-03
Effects of PIP2 hydrolysis	24	1.39e-01	-0.175000	2.81e-01
SLC transporter disorders	71	1.11e-02	-0.174000	4.33e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	28	1.10e-01	-0.174000	2.43e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	3.18e-01	-0.174000	5.05e-01
Defects in cobalamin (B12) metabolism	13	2.81e-01	0.173000	4.69e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	3.44e-01	-0.173000	5.26e-01
Advanced glycosylation endproduct receptor signaling	12	3.00e-01	-0.173000	4.87e-01
Processing and activation of SUMO	10	3.45e-01	-0.173000	5.26e-01
G-protein beta:gamma signalling	28	1.15e-01	-0.172000	2.50e-01
Lewis blood group biosynthesis	12	3.02e-01	0.172000	4.87e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	3.46e-01	-0.172000	5.26e-01
Gene Silencing by RNA	84	6.44e-03	-0.172000	2.97e-02
Class B/2 (Secretin family receptors)	66	1.60e-02	0.171000	5.85e-02
Cargo recognition for clathrin-mediated endocytosis	97	3.54e-03	-0.171000	1.90e-02
Cargo trafficking to the periciliary membrane	46	4.50e-02	0.171000	1.30e-01
Viral Messenger RNA Synthesis	44	5.07e-02	-0.170000	1.40e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	3.29e-01	-0.170000	5.15e-01
cGMP effects	15	2.57e-01	0.169000	4.41e-01
NGF-stimulated transcription	34	9.03e-02	-0.168000	2.12e-01
Synthesis of PIPs at the plasma membrane	50	4.02e-02	-0.168000	1.20e-01
Tie2 Signaling	16	2.48e-01	-0.167000	4.30e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	1.51e-01	-0.166000	2.95e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	1.51e-01	-0.166000	2.95e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	1.51e-01	-0.166000	2.95e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	1.51e-01	-0.166000	2.95e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	3.21e-02	-0.166000	1.01e-01
Intraflagellar transport	49	4.49e-02	0.166000	1.30e-01
Aspirin ADME	15	2.67e-01	-0.165000	4.51e-01
Recognition of DNA damage by PCNA-containing replication complex	30	1.17e-01	-0.165000	2.53e-01
Hyaluronan uptake and degradation	12	3.24e-01	-0.165000	5.09e-01
G2/M Checkpoints	135	9.66e-04	-0.165000	6.66e-03
IGF1R signaling cascade	41	6.83e-02	-0.165000	1.74e-01
Classical antibody-mediated complement activation	14	2.87e-01	-0.165000	4.75e-01
Regulated proteolysis of p75NTR	11	3.45e-01	-0.164000	5.26e-01
IRS-related events triggered by IGF1R	40	7.20e-02	-0.164000	1.79e-01
Nuclear Events (kinase and transcription factor activation)	56	3.36e-02	-0.164000	1.04e-01
Defective Intrinsic Pathway for Apoptosis	24	1.64e-01	-0.164000	3.19e-01
MET receptor recycling	10	3.70e-01	-0.164000	5.49e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	21	1.95e-01	-0.164000	3.63e-01
Neurodegenerative Diseases	21	1.95e-01	-0.164000	3.63e-01
FGFR1 mutant receptor activation	25	1.58e-01	-0.163000	3.09e-01
Incretin synthesis, secretion, and inactivation	14	2.91e-01	0.163000	4.78e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	14	2.91e-01	0.163000	4.78e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	2.07e-01	-0.163000	3.77e-01
Cytokine Signaling in Immune system	620	6.48e-12	-0.162000	3.13e-10
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	41	7.30e-02	-0.162000	1.81e-01
Diseases of DNA Double-Strand Break Repair	41	7.30e-02	-0.162000	1.81e-01
SUMOylation of transcription cofactors	44	6.35e-02	-0.162000	1.66e-01
DNA Replication Pre-Initiation	111	3.27e-03	-0.162000	1.79e-02
TNFR1-induced proapoptotic signaling	25	1.62e-01	-0.161000	3.17e-01
The activation of arylsulfatases	10	3.77e-01	0.161000	5.56e-01
PI-3K cascade:FGFR2	14	2.96e-01	0.161000	4.84e-01
HDR through Single Strand Annealing (SSA)	37	9.04e-02	-0.161000	2.12e-01
Uptake and function of anthrax toxins	11	3.56e-01	-0.161000	5.36e-01
Nervous system development	525	3.33e-10	0.161000	1.31e-08
Amyloid fiber formation	47	5.78e-02	-0.160000	1.56e-01
Metabolism of cofactors	19	2.28e-01	0.160000	4.04e-01
Axon guidance	505	9.46e-10	0.159000	3.54e-08
Mitochondrial protein import	63	2.88e-02	0.159000	9.32e-02
ERBB2 Regulates Cell Motility	14	3.02e-01	0.159000	4.88e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	3.21e-01	-0.159000	5.08e-01
RHOA GTPase cycle	144	1.01e-03	-0.159000	6.83e-03
Activation of GABAB receptors	33	1.15e-01	0.159000	2.50e-01
GABA B receptor activation	33	1.15e-01	0.159000	2.50e-01
Mitotic Metaphase and Anaphase	224	4.51e-05	-0.158000	4.89e-04
KSRP (KHSRP) binds and destabilizes mRNA	17	2.60e-01	-0.158000	4.42e-01
Tight junction interactions	17	2.60e-01	0.158000	4.43e-01
Chemokine receptors bind chemokines	38	9.27e-02	-0.158000	2.16e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	1.74e-01	-0.157000	3.35e-01
Mitotic Anaphase	223	5.51e-05	-0.157000	5.80e-04
Insulin receptor signalling cascade	42	7.97e-02	-0.156000	1.93e-01
RHOD GTPase cycle	52	5.14e-02	-0.156000	1.42e-01
PI-3K cascade:FGFR3	12	3.49e-01	0.156000	5.29e-01
LDL clearance	18	2.52e-01	-0.156000	4.33e-01
Role of phospholipids in phagocytosis	34	1.16e-01	-0.156000	2.50e-01
HS-GAG biosynthesis	23	1.95e-01	0.156000	3.63e-01
ERK/MAPK targets	22	2.06e-01	-0.156000	3.75e-01
Synthesis of DNA	119	3.40e-03	-0.156000	1.83e-02
PI3K Cascade	33	1.23e-01	-0.155000	2.61e-01
HIV elongation arrest and recovery	32	1.29e-01	-0.155000	2.69e-01
Pausing and recovery of HIV elongation	32	1.29e-01	-0.155000	2.69e-01
KEAP1-NFE2L2 pathway	102	6.97e-03	-0.155000	3.13e-02
Drug ADME	61	3.71e-02	-0.154000	1.12e-01
Branched-chain amino acid catabolism	21	2.22e-01	-0.154000	3.95e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	2.48e-01	-0.153000	4.30e-01
Antimicrobial peptides	31	1.42e-01	-0.153000	2.85e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	2.91e-01	-0.152000	4.78e-01
Membrane binding and targetting of GAG proteins	14	3.25e-01	-0.152000	5.10e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	3.25e-01	-0.152000	5.10e-01
DAP12 signaling	27	1.72e-01	-0.152000	3.31e-01
Mitotic G2-G2/M phases	190	3.26e-04	-0.151000	2.65e-03
GAB1 signalosome	16	2.97e-01	-0.151000	4.85e-01
Fatty acyl-CoA biosynthesis	34	1.29e-01	-0.150000	2.69e-01
Heme signaling	45	8.14e-02	-0.150000	1.96e-01
MET activates RAS signaling	11	3.89e-01	-0.150000	5.64e-01
Nicotinamide salvaging	16	3.00e-01	-0.150000	4.87e-01
Translesion synthesis by REV1	16	3.00e-01	-0.150000	4.87e-01
Lysine catabolism	11	3.90e-01	-0.150000	5.64e-01
Signaling by Interleukins	404	2.68e-07	-0.149000	5.90e-06
RHO GTPases Activate WASPs and WAVEs	36	1.24e-01	-0.148000	2.62e-01
Uptake and actions of bacterial toxins	26	1.91e-01	-0.148000	3.58e-01
Signaling by FGFR1 in disease	32	1.47e-01	-0.148000	2.92e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	2.64e-01	-0.148000	4.47e-01
TP53 Regulates Transcription of Cell Death Genes	42	9.78e-02	-0.148000	2.24e-01
RAS processing	23	2.21e-01	0.148000	3.93e-01
Listeria monocytogenes entry into host cells	19	2.66e-01	-0.147000	4.50e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.02e-01	-0.147000	3.71e-01
IRS-mediated signalling	37	1.22e-01	-0.147000	2.60e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	14	3.42e-01	0.147000	5.26e-01
Heparan sulfate/heparin (HS-GAG) metabolism	43	9.61e-02	0.147000	2.22e-01
O-linked glycosylation	90	1.63e-02	0.147000	5.94e-02
RAC2 GTPase cycle	87	1.83e-02	-0.146000	6.47e-02
FCERI mediated Ca+2 mobilization	37	1.23e-01	-0.146000	2.61e-01
Clathrin-mediated endocytosis	137	3.16e-03	-0.146000	1.74e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	3.28e-01	-0.146000	5.14e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	2.59e-01	-0.146000	4.42e-01
RHO GTPases activate CIT	19	2.72e-01	-0.146000	4.58e-01
Attenuation phase	22	2.39e-01	0.145000	4.18e-01
RAC3 GTPase cycle	89	1.82e-02	-0.145000	6.46e-02
Metabolism of non-coding RNA	53	6.87e-02	-0.145000	1.74e-01
snRNP Assembly	53	6.87e-02	-0.145000	1.74e-01
Nuclear events stimulated by ALK signaling in cancer	18	2.89e-01	-0.144000	4.78e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	42	1.06e-01	-0.144000	2.36e-01
PI3K events in ERBB2 signaling	15	3.35e-01	0.144000	5.20e-01
Glycogen breakdown (glycogenolysis)	14	3.53e-01	-0.143000	5.33e-01
G2/M Transition	188	7.22e-04	-0.143000	5.24e-03
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	3.08e-01	-0.143000	4.93e-01
Signaling by NTRK1 (TRKA)	109	1.01e-02	-0.143000	4.06e-02
Plasma lipoprotein remodeling	21	2.60e-01	-0.142000	4.42e-01
Sensory Perception	169	1.50e-03	0.142000	9.19e-03
Pausing and recovery of Tat-mediated HIV elongation	30	1.80e-01	-0.141000	3.43e-01
Tat-mediated HIV elongation arrest and recovery	30	1.80e-01	-0.141000	3.43e-01
FOXO-mediated transcription of cell cycle genes	15	3.44e-01	-0.141000	5.26e-01
RHOJ GTPase cycle	54	7.38e-02	-0.141000	1.82e-01
Activation of HOX genes during differentiation	71	4.10e-02	-0.140000	1.21e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	71	4.10e-02	-0.140000	1.21e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	1.77e-01	-0.140000	3.39e-01
RAC1 GTPase cycle	178	1.30e-03	-0.140000	8.17e-03
Cohesin Loading onto Chromatin	10	4.45e-01	-0.139000	6.08e-01
Adaptive Immune System	696	4.64e-10	-0.139000	1.78e-08
Transcriptional regulation by RUNX2	116	9.99e-03	0.139000	4.04e-02
Separation of Sister Chromatids	179	1.41e-03	-0.138000	8.76e-03
Rab regulation of trafficking	121	8.56e-03	-0.138000	3.64e-02
VLDLR internalisation and degradation	16	3.39e-01	-0.138000	5.22e-01
FCGR3A-mediated phagocytosis	68	4.94e-02	-0.138000	1.37e-01
Leishmania phagocytosis	68	4.94e-02	-0.138000	1.37e-01
Parasite infection	68	4.94e-02	-0.138000	1.37e-01
Lysosphingolipid and LPA receptors	12	4.09e-01	0.138000	5.78e-01
Signaling by ERBB2 TMD/JMD mutants	21	2.76e-01	0.137000	4.64e-01
GABA synthesis, release, reuptake and degradation	13	3.93e-01	-0.137000	5.66e-01
Transcriptional Regulation by VENTX	39	1.41e-01	-0.136000	2.83e-01
Protein-protein interactions at synapses	73	4.61e-02	0.135000	1.31e-01
Regulation of localization of FOXO transcription factors	11	4.40e-01	-0.134000	6.05e-01
TNF signaling	57	7.97e-02	-0.134000	1.93e-01
TP53 Regulates Transcription of DNA Repair Genes	61	7.05e-02	-0.134000	1.78e-01
Signaling by ERBB2 in Cancer	25	2.49e-01	0.133000	4.31e-01
RHOB GTPase cycle	66	6.37e-02	-0.132000	1.66e-01
Fatty acid metabolism	154	4.73e-03	-0.132000	2.38e-02
Oncogenic MAPK signaling	76	4.72e-02	-0.132000	1.34e-01
SHC-mediated cascade:FGFR2	14	3.94e-01	0.131000	5.68e-01
Regulation of TNFR1 signaling	48	1.15e-01	-0.131000	2.50e-01
Netrin-1 signaling	43	1.36e-01	0.131000	2.78e-01
Free fatty acids regulate insulin secretion	10	4.73e-01	-0.131000	6.33e-01
Ub-specific processing proteases	166	3.60e-03	-0.131000	1.92e-02
Gastrin-CREB signalling pathway via PKC and MAPK	16	3.65e-01	-0.131000	5.45e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	2.91e-01	-0.130000	4.78e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	635	2.54e-08	-0.130000	6.91e-07
Fcgamma receptor (FCGR) dependent phagocytosis	95	2.97e-02	-0.129000	9.57e-02
HIV Life Cycle	146	7.16e-03	-0.129000	3.20e-02
Positive epigenetic regulation of rRNA expression	58	8.99e-02	-0.129000	2.11e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	3.58e-01	-0.129000	5.38e-01
Death Receptor Signaling	150	6.53e-03	-0.129000	3.00e-02
Potassium Channels	59	8.79e-02	0.128000	2.08e-01
Signaling by FGFR2 in disease	34	1.96e-01	0.128000	3.63e-01
Platelet Adhesion to exposed collagen	15	3.90e-01	-0.128000	5.64e-01
Regulation of CDH11 function	11	4.65e-01	0.127000	6.27e-01
Methylation	13	4.28e-01	0.127000	5.93e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	50	1.22e-01	-0.126000	2.60e-01
Signaling by Rho GTPases	620	8.84e-08	-0.126000	2.17e-06
ESR-mediated signaling	163	5.51e-03	-0.126000	2.59e-02
Cell surface interactions at the vascular wall	129	1.35e-02	-0.126000	5.10e-02
Inactivation, recovery and regulation of the phototransduction cascade	21	3.19e-01	0.126000	5.05e-01
RHO GTPases activate KTN1	11	4.71e-01	-0.126000	6.31e-01
Basigin interactions	23	2.99e-01	-0.125000	4.86e-01
RET signaling	34	2.08e-01	-0.125000	3.77e-01
RAF activation	34	2.08e-01	-0.125000	3.77e-01
FRS-mediated FGFR2 signaling	16	3.88e-01	0.125000	5.64e-01
Kinesins	51	1.24e-01	-0.124000	2.62e-01
Transcriptional Regulation by MECP2	55	1.11e-01	-0.124000	2.43e-01
Regulation of TLR by endogenous ligand	15	4.04e-01	-0.124000	5.77e-01
Glutamate and glutamine metabolism	11	4.76e-01	0.124000	6.35e-01
Norepinephrine Neurotransmitter Release Cycle	15	4.05e-01	-0.124000	5.77e-01
SHC1 events in EGFR signaling	13	4.42e-01	-0.123000	6.05e-01
Signaling by Nuclear Receptors	228	1.40e-03	-0.123000	8.74e-03
COPII-mediated vesicle transport	66	8.49e-02	0.123000	2.02e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	33	2.24e-01	0.122000	3.97e-01
Class I peroxisomal membrane protein import	20	3.44e-01	-0.122000	5.26e-01
Deactivation of the beta-catenin transactivating complex	39	1.88e-01	-0.122000	3.55e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	5.06e-01	-0.122000	6.59e-01
Attachment and Entry 9694614	15	4.15e-01	0.122000	5.81e-01
Synthesis of very long-chain fatty acyl-CoAs	21	3.35e-01	-0.122000	5.20e-01
SHC-mediated cascade:FGFR3	12	4.67e-01	0.121000	6.28e-01
Assembly of active LPL and LIPC lipase complexes	13	4.49e-01	-0.121000	6.10e-01
Apoptotic execution phase	44	1.64e-01	-0.121000	3.19e-01
FCGR activation	21	3.37e-01	-0.121000	5.22e-01
Leishmania infection	161	8.14e-03	-0.121000	3.48e-02
Parasitic Infection Pathways	161	8.14e-03	-0.121000	3.48e-02
tRNA processing in the nucleus	59	1.08e-01	-0.121000	2.39e-01
RHOC GTPase cycle	71	7.87e-02	-0.121000	1.92e-01
N-Glycan antennae elongation	13	4.54e-01	-0.120000	6.14e-01
Transcriptional activation of mitochondrial biogenesis	51	1.40e-01	-0.120000	2.82e-01
Assembly Of The HIV Virion	16	4.08e-01	-0.119000	5.78e-01
GRB2 events in EGFR signaling	12	4.74e-01	-0.119000	6.34e-01
Pexophagy	11	4.93e-01	-0.119000	6.50e-01
Hedgehog ‘on’ state	83	6.07e-02	0.119000	1.61e-01
Fertilization	10	5.16e-01	-0.119000	6.67e-01
Signaling by the B Cell Receptor (BCR)	115	2.87e-02	-0.118000	9.31e-02
Fc epsilon receptor (FCERI) signaling	135	1.81e-02	-0.118000	6.43e-02
Assembly of the pre-replicative complex	95	4.82e-02	-0.117000	1.36e-01
Signaling by NTRK3 (TRKC)	16	4.17e-01	0.117000	5.82e-01
Synthesis of PIPs at the early endosome membrane	16	4.17e-01	-0.117000	5.82e-01
Nucleotide catabolism	26	3.01e-01	-0.117000	4.87e-01
p75 NTR receptor-mediated signalling	93	5.15e-02	-0.117000	1.42e-01
CTLA4 inhibitory signaling	20	3.66e-01	-0.117000	5.46e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	3.13e-01	-0.117000	4.98e-01
CDC42 GTPase cycle	150	1.39e-02	-0.116000	5.18e-02
Cell-cell junction organization	67	9.94e-02	0.116000	2.26e-01
Hyaluronan metabolism	17	4.06e-01	-0.116000	5.77e-01
Signaling by MET	75	8.16e-02	0.116000	1.96e-01
Glutamate Neurotransmitter Release Cycle	22	3.45e-01	0.116000	5.26e-01
ADP signalling through P2Y purinoceptor 12	17	4.07e-01	0.116000	5.78e-01
Cellular response to chemical stress	184	6.78e-03	-0.116000	3.07e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	5.29e-01	0.115000	6.75e-01
PIP3 activates AKT signaling	252	1.69e-03	-0.115000	1.03e-02
FRS-mediated FGFR3 signaling	14	4.57e-01	0.115000	6.18e-01
RA biosynthesis pathway	19	3.87e-01	0.115000	5.63e-01
RNA Polymerase I Promoter Escape	43	1.94e-01	0.115000	3.63e-01
Regulation of actin dynamics for phagocytic cup formation	70	9.83e-02	-0.114000	2.24e-01
Interleukin-1 signaling	110	3.90e-02	-0.114000	1.17e-01
Metabolism of lipids	629	1.16e-06	-0.114000	2.30e-05
Phosphorylation of the APC/C	20	3.79e-01	-0.114000	5.57e-01
Synaptic adhesion-like molecules	20	3.80e-01	0.113000	5.57e-01
RHO GTPases activate PAKs	21	3.68e-01	-0.113000	5.48e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	4.79e-01	-0.113000	6.38e-01
TCR signaling	107	4.30e-02	-0.113000	1.26e-01
NOD1/2 Signaling Pathway	36	2.41e-01	-0.113000	4.21e-01
Translesion synthesis by POLK	17	4.20e-01	-0.113000	5.85e-01
Phase I - Functionalization of compounds	72	9.76e-02	-0.113000	2.24e-01
EPH-ephrin mediated repulsion of cells	47	1.81e-01	0.113000	3.45e-01
ATF6 (ATF6-alpha) activates chaperones	12	4.99e-01	0.113000	6.55e-01
Negative regulation of the PI3K/AKT network	97	5.57e-02	-0.112000	1.51e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	3.40e-01	0.112000	5.24e-01
RHOQ GTPase cycle	58	1.39e-01	-0.112000	2.82e-01
DARPP-32 events	23	3.53e-01	-0.112000	5.33e-01
Activation of kainate receptors upon glutamate binding	25	3.33e-01	0.112000	5.20e-01
Anchoring of the basal body to the plasma membrane	96	5.87e-02	-0.112000	1.57e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	1.23e-01	0.112000	2.61e-01
Signaling by FGFR4 in disease	10	5.42e-01	-0.111000	6.84e-01
Signaling by ERBB2 KD Mutants	24	3.46e-01	0.111000	5.26e-01
Regulation of Expression and Function of Type II Classical Cadherins	28	3.10e-01	-0.111000	4.96e-01
Regulation of Homotypic Cell-Cell Adhesion	28	3.10e-01	-0.111000	4.96e-01
SLBP independent Processing of Histone Pre-mRNAs	10	5.44e-01	0.111000	6.84e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	5.45e-01	-0.111000	6.84e-01
Intracellular signaling by second messengers	289	1.28e-03	-0.110000	8.09e-03
Downstream signal transduction	28	3.13e-01	-0.110000	4.98e-01
Insulin receptor recycling	26	3.33e-01	0.110000	5.19e-01
Formation of apoptosome	11	5.29e-01	-0.110000	6.75e-01
Regulation of the apoptosome activity	11	5.29e-01	-0.110000	6.75e-01
IL-6-type cytokine receptor ligand interactions	15	4.62e-01	0.110000	6.24e-01
Glucagon-type ligand receptors	21	3.86e-01	0.109000	5.63e-01
NF-kB is activated and signals survival	13	4.96e-01	-0.109000	6.52e-01
Interleukin-1 family signaling	139	2.67e-02	-0.109000	8.84e-02
Intrinsic Pathway of Fibrin Clot Formation	15	4.66e-01	-0.109000	6.27e-01
Regulation of TP53 Activity through Association with Co-factors	12	5.14e-01	-0.109000	6.65e-01
Dectin-2 family	16	4.52e-01	-0.108000	6.13e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	5.53e-01	0.108000	6.90e-01
NOTCH1 Intracellular Domain Regulates Transcription	47	2.00e-01	-0.108000	3.68e-01
Diseases associated with N-glycosylation of proteins	20	4.03e-01	-0.108000	5.76e-01
Purine salvage	13	5.02e-01	-0.108000	6.57e-01
Metabolism of Angiotensinogen to Angiotensins	15	4.72e-01	0.107000	6.33e-01
Glyoxylate metabolism and glycine degradation	24	3.66e-01	0.107000	5.45e-01
HSF1-dependent transactivation	32	2.98e-01	0.106000	4.86e-01
Deadenylation-dependent mRNA decay	50	1.95e-01	-0.106000	3.63e-01
Signaling by NTRKs	126	4.06e-02	-0.106000	1.21e-01
MET activates RAP1 and RAC1	11	5.44e-01	-0.106000	6.84e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	3.62e-01	0.105000	5.42e-01
SHC1 events in ERBB2 signaling	21	4.04e-01	0.105000	5.77e-01
TCF dependent signaling in response to WNT	172	1.77e-02	-0.105000	6.33e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	4.17e-01	-0.105000	5.82e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	2.77e-01	-0.105000	4.64e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	5.30e-01	-0.105000	6.76e-01
Inhibition of DNA recombination at telomere	32	3.06e-01	-0.105000	4.93e-01
CaM pathway	32	3.07e-01	-0.104000	4.93e-01
Calmodulin induced events	32	3.07e-01	-0.104000	4.93e-01
MHC class II antigen presentation	100	7.21e-02	-0.104000	1.79e-01
PKA activation in glucagon signalling	15	4.85e-01	-0.104000	6.45e-01
PTEN Regulation	139	3.44e-02	-0.104000	1.05e-01
Late Phase of HIV Life Cycle	133	3.87e-02	-0.104000	1.16e-01
Diseases of carbohydrate metabolism	29	3.34e-01	-0.104000	5.20e-01
Diseases of metabolism	206	1.05e-02	0.104000	4.15e-02
Regulation of RUNX2 expression and activity	70	1.38e-01	0.103000	2.80e-01
Apoptotic cleavage of cellular proteins	36	2.87e-01	-0.103000	4.76e-01
EGFR downregulation	29	3.40e-01	-0.102000	5.23e-01
IRAK1 recruits IKK complex	14	5.07e-01	-0.102000	6.59e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	5.07e-01	-0.102000	6.59e-01
RHO GTPases Activate ROCKs	19	4.40e-01	-0.102000	6.05e-01
Signaling by FGFR3 in disease	16	4.79e-01	0.102000	6.38e-01
Downregulation of ERBB2:ERBB3 signaling	13	5.24e-01	0.102000	6.72e-01
Nuclear signaling by ERBB4	30	3.34e-01	-0.102000	5.20e-01
Signaling by NOTCH1	72	1.35e-01	-0.102000	2.76e-01
Plasma lipoprotein clearance	34	3.08e-01	-0.101000	4.93e-01
G beta:gamma signalling through BTK	14	5.13e-01	0.101000	6.64e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	3.59e-01	0.100000	5.39e-01
RHOG GTPase cycle	72	1.42e-01	-0.100000	2.85e-01
Purine catabolism	13	5.33e-01	0.099900	6.77e-01
Synthesis of PA	33	3.22e-01	-0.099700	5.08e-01
Constitutive Signaling by EGFRvIII	15	5.05e-01	-0.099500	6.59e-01
Signaling by EGFRvIII in Cancer	15	5.05e-01	-0.099500	6.59e-01
Dual Incision in GG-NER	41	2.73e-01	-0.099000	4.59e-01
Complement cascade	46	2.46e-01	-0.098900	4.28e-01
Lysosome Vesicle Biogenesis	32	3.34e-01	-0.098700	5.20e-01
G-protein mediated events	50	2.28e-01	-0.098600	4.03e-01
Retrograde transport at the Trans-Golgi-Network	49	2.33e-01	-0.098500	4.10e-01
PLC beta mediated events	46	2.48e-01	-0.098400	4.30e-01
Downregulation of TGF-beta receptor signaling	26	3.87e-01	0.098100	5.63e-01
COPI-mediated anterograde transport	92	1.04e-01	0.098100	2.33e-01
Ca-dependent events	34	3.23e-01	-0.098000	5.08e-01
Neurexins and neuroligins	48	2.40e-01	0.098000	4.20e-01
Mitophagy	28	3.70e-01	0.097900	5.49e-01
Serotonin Neurotransmitter Release Cycle	16	4.98e-01	-0.097800	6.55e-01
Interleukin-4 and Interleukin-13 signaling	97	9.71e-02	-0.097500	2.23e-01
NRAGE signals death through JNK	56	2.07e-01	-0.097500	3.76e-01
RAB GEFs exchange GTP for GDP on RABs	88	1.15e-01	-0.097200	2.50e-01
Formation of Fibrin Clot (Clotting Cascade)	26	3.92e-01	-0.097000	5.65e-01
Metabolism of nucleotides	85	1.24e-01	-0.096600	2.62e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	17	4.91e-01	0.096600	6.49e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	5.63e-01	-0.096500	6.99e-01
Transferrin endocytosis and recycling	28	3.77e-01	0.096500	5.56e-01
ER to Golgi Anterograde Transport	143	4.76e-02	0.096000	1.35e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	90	1.16e-01	-0.096000	2.50e-01
Signaling by ERBB2	48	2.50e-01	0.095900	4.32e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	4.47e-01	-0.095900	6.08e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	4.47e-01	-0.095900	6.08e-01
SARS-CoV Infections	385	1.28e-03	-0.095800	8.09e-03
The phototransduction cascade	22	4.38e-01	0.095500	6.04e-01
Interleukin-12 family signaling	49	2.50e-01	-0.095100	4.31e-01
PI3K/AKT Signaling in Cancer	90	1.20e-01	-0.094900	2.57e-01
Acetylcholine Neurotransmitter Release Cycle	13	5.54e-01	-0.094700	6.90e-01
Hemostasis	530	2.19e-04	-0.094000	1.90e-03
Switching of origins to a post-replicative state	90	1.27e-01	-0.093200	2.65e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	16	5.21e-01	-0.092700	6.70e-01
G beta:gamma signalling through PLC beta	16	5.22e-01	0.092500	6.70e-01
Binding and Uptake of Ligands by Scavenger Receptors	41	3.06e-01	0.092400	4.92e-01
HS-GAG degradation	20	4.75e-01	0.092300	6.34e-01
Induction of Cell-Cell Fusion	10	6.14e-01	-0.092200	7.39e-01
RIPK1-mediated regulated necrosis	31	3.76e-01	-0.091800	5.56e-01
Regulation of necroptotic cell death	31	3.76e-01	-0.091800	5.56e-01
IRAK2 mediated activation of TAK1 complex	10	6.16e-01	-0.091700	7.40e-01
Activated NTRK2 signals through FRS2 and FRS3	10	6.16e-01	-0.091500	7.41e-01
Programmed Cell Death	196	2.79e-02	-0.091200	9.20e-02
Gene expression (Transcription)	1395	1.43e-08	-0.091100	4.27e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	2.15e-01	-0.091100	3.86e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	4.93e-01	-0.090900	6.50e-01
Signaling by EGFR	48	2.78e-01	-0.090500	4.66e-01
RHOV GTPase cycle	36	3.49e-01	-0.090200	5.29e-01
Regulation of CDH11 Expression and Function	26	4.27e-01	-0.090000	5.93e-01
Nuclear events mediated by NFE2L2	77	1.73e-01	-0.089900	3.33e-01
Protein methylation	15	5.47e-01	0.089900	6.86e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	4.88e-01	-0.089700	6.47e-01
Formation of the Early Elongation Complex	33	3.76e-01	0.089000	5.56e-01
Formation of the HIV-1 Early Elongation Complex	33	3.76e-01	0.089000	5.56e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	2.20e-01	-0.088700	3.92e-01
Metabolism of water-soluble vitamins and cofactors	113	1.04e-01	-0.088500	2.33e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	4.45e-01	0.088200	6.08e-01
Spry regulation of FGF signaling	16	5.43e-01	-0.087800	6.84e-01
Late SARS-CoV-2 Infection Events	67	2.17e-01	-0.087300	3.87e-01
Disorders of transmembrane transporters	142	7.30e-02	-0.087200	1.81e-01
Apoptosis	167	5.32e-02	-0.086800	1.45e-01
Host Interactions of HIV factors	127	9.26e-02	-0.086500	2.16e-01
Translation of Structural Proteins 9694635	57	2.59e-01	-0.086400	4.42e-01
HIV Infection	224	2.61e-02	-0.086400	8.69e-02
Ubiquitin-dependent degradation of Cyclin D	50	2.91e-01	0.086300	4.78e-01
Downstream signaling of activated FGFR2	21	4.95e-01	0.085900	6.52e-01
Cell death signalling via NRAGE, NRIF and NADE	73	2.04e-01	-0.085900	3.73e-01
Plasma lipoprotein assembly, remodeling, and clearance	59	2.57e-01	-0.085400	4.41e-01
Regulation of RAS by GAPs	66	2.31e-01	0.085200	4.08e-01
VEGFR2 mediated cell proliferation	19	5.21e-01	0.085100	6.70e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	27	4.46e-01	0.084700	6.08e-01
Nephrin family interactions	20	5.13e-01	0.084400	6.64e-01
Vif-mediated degradation of APOBEC3G	52	2.92e-01	0.084400	4.79e-01
Phase 2 - plateau phase	10	6.44e-01	0.084300	7.61e-01
Presynaptic function of Kainate receptors	17	5.48e-01	0.084200	6.86e-01
Cyclin A:Cdk2-associated events at S phase entry	85	1.80e-01	-0.084200	3.43e-01
PI-3K cascade:FGFR1	13	6.00e-01	0.084100	7.28e-01
Golgi Associated Vesicle Biogenesis	55	2.82e-01	-0.083900	4.69e-01
IRE1alpha activates chaperones	50	3.06e-01	-0.083700	4.92e-01
Signalling to ERKs	33	4.05e-01	-0.083700	5.77e-01
G beta:gamma signalling through PI3Kgamma	21	5.07e-01	-0.083700	6.59e-01
Orc1 removal from chromatin	69	2.30e-01	-0.083500	4.07e-01
Signaling by NOTCH	185	5.07e-02	-0.083400	1.40e-01
Transcriptional Regulation by NPAS4	31	4.23e-01	-0.083100	5.88e-01
RHO GTPase cycle	426	3.33e-03	-0.083100	1.81e-02
Glutathione conjugation	29	4.40e-01	-0.082900	6.05e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	28	4.50e-01	0.082500	6.11e-01
Trafficking of AMPA receptors	28	4.50e-01	0.082500	6.11e-01
Blood group systems biosynthesis	16	5.68e-01	-0.082400	7.04e-01
Adherens junctions interactions	48	3.25e-01	0.082200	5.10e-01
GRB2 events in ERBB2 signaling	15	5.83e-01	0.081900	7.15e-01
RNA Polymerase III Transcription Initiation	36	3.96e-01	0.081800	5.68e-01
Plasma lipoprotein assembly	11	6.41e-01	0.081200	7.59e-01
COPI-independent Golgi-to-ER retrograde traffic	44	3.54e-01	-0.080700	5.34e-01
RNA Polymerase II Transcription	1236	2.22e-06	-0.080500	4.00e-05
Regulation of Apoptosis	51	3.21e-01	0.080300	5.08e-01
Cytoprotection by HMOX1	58	2.90e-01	-0.080300	4.78e-01
Transport of bile salts and organic acids, metal ions and amine compounds	49	3.32e-01	0.080100	5.19e-01
Signaling by NOTCH3	47	3.42e-01	-0.080000	5.26e-01
Negative epigenetic regulation of rRNA expression	61	2.83e-01	-0.079400	4.72e-01
Hedgehog ligand biogenesis	61	2.86e-01	0.079000	4.75e-01
RNA Polymerase III Abortive And Retractive Initiation	41	3.82e-01	0.078900	5.58e-01
RNA Polymerase III Transcription	41	3.82e-01	0.078900	5.58e-01
Peroxisomal protein import	58	3.00e-01	-0.078700	4.87e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	3.22e-01	0.078600	5.08e-01
XBP1(S) activates chaperone genes	48	3.47e-01	-0.078500	5.26e-01
Association of TriC/CCT with target proteins during biosynthesis	35	4.23e-01	-0.078300	5.88e-01
Voltage gated Potassium channels	20	5.46e-01	-0.077900	6.86e-01
ABC-family proteins mediated transport	94	1.93e-01	-0.077700	3.62e-01
Circadian Clock	67	2.73e-01	-0.077500	4.59e-01
Prostacyclin signalling through prostacyclin receptor	15	6.05e-01	0.077200	7.33e-01
Cytochrome c-mediated apoptotic response	13	6.30e-01	-0.077100	7.51e-01
VEGFR2 mediated vascular permeability	27	4.88e-01	-0.077000	6.47e-01
UCH proteinases	87	2.15e-01	-0.077000	3.86e-01
TNFs bind their physiological receptors	25	5.05e-01	0.076900	6.59e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	3.39e-01	0.076700	5.22e-01
CaMK IV-mediated phosphorylation of CREB	10	6.75e-01	-0.076500	7.82e-01
Generic Transcription Pathway	1118	1.81e-05	-0.076400	2.39e-04
p75NTR signals via NF-kB	16	5.97e-01	-0.076400	7.25e-01
Sulfur amino acid metabolism	24	5.19e-01	-0.076000	6.70e-01
Signaling by Activin	14	6.26e-01	-0.075300	7.46e-01
trans-Golgi Network Vesicle Budding	69	2.82e-01	-0.075000	4.69e-01
Citric acid cycle (TCA cycle)	22	5.44e-01	-0.074800	6.84e-01
Downstream signaling of activated FGFR3	19	5.73e-01	0.074800	7.07e-01
Signal Transduction	2147	2.34e-08	-0.074000	6.60e-07
Platelet degranulation	113	1.75e-01	0.074000	3.35e-01
Biological oxidations	146	1.23e-01	-0.073900	2.61e-01
Assembly and cell surface presentation of NMDA receptors	36	4.44e-01	0.073700	6.07e-01
Amino acids regulate mTORC1	50	3.68e-01	0.073600	5.48e-01
Azathioprine ADME	19	5.79e-01	-0.073500	7.13e-01
Regulation of Complement cascade	41	4.16e-01	-0.073500	5.82e-01
Interleukin-12 signaling	42	4.11e-01	-0.073400	5.78e-01
Bile acid and bile salt metabolism	30	4.89e-01	-0.073100	6.47e-01
Anti-inflammatory response favouring Leishmania parasite infection	79	2.63e-01	-0.072900	4.45e-01
Leishmania parasite growth and survival	79	2.63e-01	-0.072900	4.45e-01
ADP signalling through P2Y purinoceptor 1	21	5.65e-01	0.072500	7.01e-01
DNA Damage Recognition in GG-NER	38	4.41e-01	-0.072300	6.05e-01
APC/C-mediated degradation of cell cycle proteins	86	2.48e-01	-0.072200	4.30e-01
Regulation of mitotic cell cycle	86	2.48e-01	-0.072200	4.30e-01
Cross-presentation of soluble exogenous antigens (endosomes)	46	3.98e-01	0.072000	5.71e-01
G-protein activation	19	5.89e-01	0.071600	7.19e-01
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	12	6.69e-01	0.071400	7.77e-01
Degradation of GLI2 by the proteasome	57	3.52e-01	0.071300	5.32e-01
Cyclin E associated events during G1/S transition	83	2.62e-01	-0.071300	4.45e-01
HIV Transcription Initiation	45	4.12e-01	0.070800	5.78e-01
RNA Polymerase II HIV Promoter Escape	45	4.12e-01	0.070800	5.78e-01
RNA Polymerase II Promoter Escape	45	4.12e-01	0.070800	5.78e-01
RNA Polymerase II Transcription Initiation	45	4.12e-01	0.070800	5.78e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	4.12e-01	0.070800	5.78e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	4.12e-01	0.070800	5.78e-01
TGF-beta receptor signaling activates SMADs	45	4.12e-01	0.070700	5.78e-01
Hh mutants abrogate ligand secretion	56	3.62e-01	0.070500	5.41e-01
Autodegradation of the E3 ubiquitin ligase COP1	49	3.95e-01	0.070300	5.68e-01
Ca2+ pathway	57	3.60e-01	0.070200	5.39e-01
Negative regulation of FGFR2 signaling	25	5.44e-01	0.070100	6.84e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	5.22e-01	0.069900	6.70e-01
rRNA modification in the nucleus and cytosol	59	3.54e-01	0.069800	5.34e-01
GLI3 is processed to GLI3R by the proteasome	57	3.63e-01	0.069600	5.43e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	6.90e-01	0.069400	7.89e-01
RNA Polymerase III Chain Elongation	18	6.12e-01	0.069000	7.39e-01
Diseases of signal transduction by growth factor receptors and second messengers	402	1.79e-02	-0.069000	6.36e-02
Sensory perception of taste	18	6.13e-01	0.068900	7.39e-01
Neuronal System	290	4.39e-02	0.068900	1.27e-01
Peptide ligand-binding receptors	91	2.57e-01	-0.068700	4.41e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	79	2.92e-01	-0.068700	4.78e-01
Pyruvate metabolism	27	5.37e-01	0.068600	6.80e-01
SHC1 events in ERBB4 signaling	13	6.69e-01	0.068600	7.77e-01
Nucleotide Excision Repair	110	2.17e-01	-0.068200	3.87e-01
p130Cas linkage to MAPK signaling for integrins	12	6.83e-01	-0.068200	7.87e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	77	3.01e-01	-0.068100	4.87e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	28	5.33e-01	0.068000	6.77e-01
Gap junction degradation	12	6.84e-01	0.067900	7.87e-01
Retinoid metabolism and transport	30	5.20e-01	0.067800	6.70e-01
Interconversion of nucleotide di- and triphosphates	28	5.35e-01	0.067800	6.79e-01
Synthesis of IP2, IP, and Ins in the cytosol	12	6.85e-01	-0.067600	7.88e-01
Cellular response to hypoxia	72	3.22e-01	0.067500	5.08e-01
FCGR3A-mediated IL10 synthesis	45	4.34e-01	-0.067400	6.00e-01
Disease	1524	1.32e-05	-0.067300	1.85e-04
Class I MHC mediated antigen processing & presentation	354	3.00e-02	-0.067200	9.65e-02
Ephrin signaling	19	6.12e-01	0.067200	7.39e-01
Iron uptake and transport	55	3.89e-01	0.067200	5.64e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	3.81e-01	-0.067100	5.57e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	3.81e-01	-0.067100	5.57e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	3.81e-01	-0.067100	5.57e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	3.81e-01	-0.067100	5.57e-01
Signaling by NOTCH1 in Cancer	57	3.81e-01	-0.067100	5.57e-01
SARS-CoV-1-host interactions	94	2.61e-01	0.067100	4.44e-01
Cell junction organization	91	2.70e-01	0.066900	4.55e-01
Interaction between L1 and Ankyrins	27	5.48e-01	0.066900	6.86e-01
Sensory processing of sound by inner hair cells of the cochlea	55	3.92e-01	0.066800	5.65e-01
The canonical retinoid cycle in rods (twilight vision)	12	6.89e-01	0.066700	7.89e-01
RNA Polymerase III Transcription Termination	23	5.80e-01	0.066700	7.14e-01
Response to elevated platelet cytosolic Ca2+	117	2.14e-01	0.066600	3.85e-01
DAG and IP3 signaling	38	4.79e-01	-0.066400	6.38e-01
Developmental Biology	826	1.25e-03	0.066300	8.06e-03
Signaling by TGF-beta Receptor Complex	90	2.78e-01	-0.066100	4.66e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	5.31e-01	-0.066000	6.77e-01
mRNA Splicing - Minor Pathway	50	4.20e-01	-0.065900	5.85e-01
Somitogenesis	50	4.22e-01	0.065600	5.87e-01
Signaling by WNT	260	6.90e-02	-0.065600	1.75e-01
ATF4 activates genes in response to endoplasmic reticulum stress	27	5.59e-01	-0.064900	6.95e-01
Autophagy	139	1.87e-01	-0.064800	3.55e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	6.76e-01	0.064500	7.82e-01
Macroautophagy	124	2.15e-01	-0.064500	3.86e-01
RHOBTB2 GTPase cycle	23	5.93e-01	0.064400	7.22e-01
G alpha (i) signalling events	201	1.17e-01	-0.064200	2.52e-01
Glycogen synthesis	13	6.88e-01	0.064200	7.89e-01
Degradation of beta-catenin by the destruction complex	83	3.13e-01	-0.064100	4.98e-01
FCERI mediated NF-kB activation	85	3.08e-01	-0.064000	4.93e-01
Regulated Necrosis	56	4.08e-01	-0.063900	5.78e-01
GPCR downstream signalling	402	2.86e-02	-0.063700	9.31e-02
Mitochondrial tRNA aminoacylation	21	6.14e-01	-0.063700	7.39e-01
RNA Polymerase I Promoter Clearance	62	3.87e-01	-0.063500	5.63e-01
RNA Polymerase I Transcription	62	3.87e-01	-0.063500	5.63e-01
G alpha (s) signalling events	95	2.85e-01	-0.063500	4.74e-01
VxPx cargo-targeting to cilium	18	6.41e-01	-0.063400	7.59e-01
Interleukin-6 family signaling	22	6.07e-01	-0.063400	7.34e-01
Transport to the Golgi and subsequent modification	168	1.57e-01	0.063300	3.07e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	4.50e-01	0.063000	6.11e-01
PIWI-interacting RNA (piRNA) biogenesis	21	6.19e-01	0.062700	7.41e-01
Vpu mediated degradation of CD4	50	4.44e-01	0.062600	6.07e-01
MTOR signalling	40	4.94e-01	-0.062500	6.50e-01
Signaling by NOTCH2	32	5.41e-01	-0.062500	6.84e-01
Pre-NOTCH Processing in Golgi	18	6.46e-01	0.062500	7.62e-01
Visual phototransduction	62	3.95e-01	0.062400	5.68e-01
Vitamin D (calciferol) metabolism	10	7.33e-01	-0.062400	8.23e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	6.86e-01	-0.062400	7.88e-01
Maturation of spike protein 9694548	37	5.12e-01	-0.062300	6.64e-01
APC-Cdc20 mediated degradation of Nek2A	26	5.84e-01	-0.062000	7.15e-01
PKA activation	16	6.68e-01	-0.061900	7.77e-01
Degradation of AXIN	53	4.38e-01	0.061700	6.04e-01
Signaling by Hedgehog	140	2.08e-01	0.061600	3.77e-01
Protein ubiquitination	68	3.81e-01	-0.061500	5.57e-01
Cholesterol biosynthesis	26	5.89e-01	0.061200	7.19e-01
Cytosolic sulfonation of small molecules	19	6.45e-01	0.061100	7.61e-01
Neurotransmitter receptors and postsynaptic signal transmission	152	1.96e-01	0.060800	3.63e-01
Processing of SMDT1	15	6.84e-01	-0.060600	7.87e-01
Common Pathway of Fibrin Clot Formation	13	7.08e-01	0.060000	8.07e-01
Transmission across Chemical Synapses	201	1.46e-01	0.059500	2.90e-01
Negative regulation of FGFR3 signaling	23	6.21e-01	0.059500	7.42e-01
Antigen processing: Ubiquitination & Proteasome degradation	292	8.08e-02	-0.059500	1.95e-01
Hedgehog ‘off’ state	105	2.95e-01	0.059100	4.83e-01
C-type lectin receptors (CLRs)	125	2.54e-01	-0.059100	4.37e-01
Formation of Incision Complex in GG-NER	43	5.05e-01	0.058800	6.59e-01
Platelet activation, signaling and aggregation	234	1.22e-01	-0.058700	2.60e-01
Infectious disease	857	3.82e-03	-0.058400	1.99e-02
COPI-dependent Golgi-to-ER retrograde traffic	90	3.46e-01	0.057500	5.26e-01
RHOBTB1 GTPase cycle	23	6.34e-01	0.057400	7.54e-01
Metabolism of polyamines	56	4.58e-01	0.057400	6.19e-01
Signaling by Retinoic Acid	38	5.41e-01	0.057300	6.84e-01
Integration of energy metabolism	94	3.38e-01	-0.057200	5.22e-01
Smooth Muscle Contraction	37	5.54e-01	0.056300	6.90e-01
Synthesis, secretion, and deacylation of Ghrelin	13	7.27e-01	-0.056000	8.20e-01
VEGFA-VEGFR2 Pathway	96	3.43e-01	-0.056000	5.26e-01
Degradation of GLI1 by the proteasome	57	4.67e-01	0.055700	6.28e-01
Regulation of PTEN stability and activity	67	4.32e-01	0.055600	5.97e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	6.53e-01	0.055300	7.68e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	33	5.83e-01	0.055200	7.15e-01
FRS-mediated FGFR1 signaling	15	7.11e-01	0.055200	8.08e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	7.22e-01	0.055000	8.16e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	6.45e-01	-0.054400	7.61e-01
Diseases associated with glycosylation precursor biosynthesis	15	7.16e-01	0.054200	8.12e-01
Signaling by FGFR1	41	5.52e-01	0.053700	6.90e-01
Formation of TC-NER Pre-Incision Complex	53	5.00e-01	0.053600	6.55e-01
G alpha (z) signalling events	38	5.67e-01	-0.053600	7.03e-01
Signaling by VEGF	104	3.46e-01	-0.053600	5.26e-01
Josephin domain DUBs	10	7.70e-01	-0.053300	8.49e-01
Metabolic disorders of biological oxidation enzymes	23	6.59e-01	-0.053200	7.72e-01
Class A/1 (Rhodopsin-like receptors)	166	2.37e-01	-0.053200	4.16e-01
MAPK1/MAPK3 signaling	255	1.45e-01	-0.053100	2.89e-01
Activation of RAC1	12	7.51e-01	-0.052900	8.33e-01
RHOBTB GTPase Cycle	35	5.91e-01	0.052500	7.21e-01
Gastrulation	87	3.99e-01	0.052400	5.71e-01
Signaling by EGFR in Cancer	24	6.58e-01	-0.052200	7.72e-01
Cardiogenesis	20	6.87e-01	0.052000	7.88e-01
SHC-mediated cascade:FGFR1	13	7.45e-01	0.052000	8.31e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	7.46e-01	-0.051800	8.31e-01
EPH-Ephrin signaling	88	4.03e-01	0.051600	5.76e-01
Platelet calcium homeostasis	23	6.70e-01	-0.051400	7.78e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	5.19e-01	0.051300	6.69e-01
Downstream signaling of activated FGFR1	22	6.78e-01	0.051100	7.84e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	4.39e-01	-0.050700	6.05e-01
GPER1 signaling	38	5.89e-01	0.050600	7.19e-01
MAPK family signaling cascades	291	1.38e-01	-0.050600	2.80e-01
Post-translational modification: synthesis of GPI-anchored proteins	63	4.87e-01	0.050600	6.47e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	7.35e-01	-0.050500	8.24e-01
Antigen processing-Cross presentation	93	4.03e-01	-0.050200	5.76e-01
RND3 GTPase cycle	38	5.94e-01	-0.049900	7.23e-01
Hh mutants are degraded by ERAD	53	5.32e-01	0.049700	6.77e-01
Cellular hexose transport	16	7.32e-01	-0.049500	8.23e-01
Nucleotide-like (purinergic) receptors	15	7.40e-01	0.049400	8.27e-01
Dual incision in TC-NER	65	4.93e-01	-0.049200	6.50e-01
Cellular response to heat stress	96	4.06e-01	-0.049100	5.77e-01
Gluconeogenesis	28	6.54e-01	-0.048900	7.69e-01
CLEC7A (Dectin-1) signaling	96	4.08e-01	-0.048800	5.78e-01
Signaling by Insulin receptor	67	4.91e-01	-0.048600	6.49e-01
Sensory processing of sound	58	5.22e-01	0.048600	6.70e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	7.39e-01	-0.048200	8.26e-01
Metabolism of folate and pterines	17	7.32e-01	-0.048000	8.23e-01
Regulation of HSF1-mediated heat shock response	78	4.66e-01	-0.047800	6.27e-01
NoRC negatively regulates rRNA expression	58	5.29e-01	-0.047800	6.75e-01
Early SARS-CoV-2 Infection Events	33	6.35e-01	0.047800	7.55e-01
RAF/MAP kinase cascade	249	1.98e-01	-0.047400	3.67e-01
Signaling by FGFR2	61	5.23e-01	0.047300	6.70e-01
Negative regulation of NOTCH4 signaling	54	5.48e-01	0.047200	6.86e-01
Metabolism of fat-soluble vitamins	33	6.40e-01	0.047100	7.58e-01
Signalling to RAS	20	7.17e-01	0.046800	8.12e-01
Cytochrome P450 - arranged by substrate type	38	6.19e-01	0.046600	7.41e-01
Signaling by GPCR	452	9.14e-02	-0.046400	2.14e-01
Negative regulation of FGFR1 signaling	25	6.90e-01	0.046100	7.89e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	6.79e-01	0.046100	7.84e-01
Post-chaperonin tubulin folding pathway	17	7.43e-01	-0.046000	8.29e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	8.01e-01	0.045900	8.72e-01
TRP channels	20	7.22e-01	-0.045900	8.16e-01
Alpha-protein kinase 1 signaling pathway	11	7.93e-01	-0.045700	8.65e-01
HSF1 activation	25	6.96e-01	0.045100	7.95e-01
Acyl chain remodelling of PC	21	7.21e-01	-0.045000	8.16e-01
Signaling by FGFR	72	5.10e-01	0.045000	6.61e-01
Opioid Signalling	81	4.90e-01	-0.044400	6.48e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	32	6.64e-01	0.044400	7.76e-01
Regulation of RUNX3 expression and activity	55	5.69e-01	0.044400	7.04e-01
Synthesis of substrates in N-glycan biosythesis	59	5.56e-01	0.044400	6.92e-01
SARS-CoV-2 Infection	265	2.22e-01	-0.043600	3.95e-01
p38MAPK events	13	7.88e-01	0.043000	8.64e-01
tRNA processing	109	4.42e-01	-0.042700	6.05e-01
Degradation of DVL	55	5.85e-01	0.042600	7.15e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	7.85e-01	0.042200	8.61e-01
Sema3A PAK dependent Axon repulsion	16	7.70e-01	0.042200	8.49e-01
Downstream TCR signaling	86	5.00e-01	-0.042100	6.55e-01
tRNA Aminoacylation	42	6.39e-01	0.041900	7.58e-01
Regulation of ornithine decarboxylase (ODC)	48	6.19e-01	0.041500	7.41e-01
Metabolism of proteins	1677	5.11e-03	0.041400	2.52e-02
Cell-Cell communication	122	4.30e-01	0.041400	5.96e-01
Autodegradation of Cdh1 by Cdh1:APC/C	64	5.70e-01	0.041100	7.05e-01
Stabilization of p53	54	6.02e-01	0.041000	7.31e-01
Ion transport by P-type ATPases	46	6.31e-01	0.040900	7.52e-01
Signal amplification	28	7.09e-01	0.040700	8.07e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	6.19e-01	0.040600	7.41e-01
p53-Independent DNA Damage Response	50	6.19e-01	0.040600	7.41e-01
p53-Independent G1/S DNA damage checkpoint	50	6.19e-01	0.040600	7.41e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	30	7.01e-01	-0.040600	7.99e-01
Detoxification of Reactive Oxygen Species	33	6.88e-01	-0.040400	7.88e-01
Membrane Trafficking	588	9.52e-02	-0.040400	2.20e-01
SARS-CoV-2-host interactions	175	3.58e-01	-0.040300	5.38e-01
EPHB-mediated forward signaling	42	6.52e-01	0.040200	7.68e-01
Viral Infection Pathways	676	7.69e-02	-0.040000	1.88e-01
PI-3K cascade:FGFR4	12	8.12e-01	0.039600	8.79e-01
Activation of NMDA receptors and postsynaptic events	82	5.35e-01	0.039600	6.79e-01
Sema4D induced cell migration and growth-cone collapse	20	7.61e-01	-0.039300	8.41e-01
Ion channel transport	146	4.15e-01	0.039100	5.81e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	5.37e-01	-0.039000	6.80e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	5.32e-01	-0.038800	6.77e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	8.09e-01	-0.038800	8.77e-01
Post NMDA receptor activation events	70	5.76e-01	0.038700	7.10e-01
tRNA modification in the nucleus and cytosol	43	6.64e-01	0.038200	7.77e-01
P2Y receptors	11	8.28e-01	0.037800	8.93e-01
Thrombin signalling through proteinase activated receptors (PARs)	26	7.39e-01	-0.037800	8.26e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	74	5.79e-01	0.037300	7.13e-01
Formation of tubulin folding intermediates by CCT/TriC	20	7.74e-01	0.037200	8.52e-01
Regulation of insulin secretion	65	6.06e-01	0.037000	7.34e-01
Thromboxane signalling through TP receptor	20	7.75e-01	0.036900	8.54e-01
Mitochondrial biogenesis	87	5.53e-01	0.036800	6.90e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	17	7.93e-01	-0.036700	8.65e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	7.31e-01	-0.036200	8.23e-01
Metabolism of carbohydrates	260	3.16e-01	-0.036100	5.03e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	15	8.09e-01	-0.036100	8.77e-01
RNA Polymerase II Pre-transcription Events	77	5.84e-01	-0.036100	7.15e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	8.29e-01	0.036000	8.93e-01
Regulation of APC/C activators between G1/S and early anaphase	79	5.81e-01	-0.035900	7.14e-01
Beta-catenin independent WNT signaling	138	4.69e-01	0.035800	6.29e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	8.38e-01	0.035700	8.98e-01
Metabolism of vitamins and cofactors	163	4.34e-01	-0.035500	6.00e-01
Activation of AMPK downstream of NMDARs	20	7.84e-01	-0.035400	8.61e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	7.91e-01	-0.035200	8.65e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	7.91e-01	-0.035200	8.65e-01
Dectin-1 mediated noncanonical NF-kB signaling	58	6.44e-01	0.035100	7.61e-01
Apoptotic factor-mediated response	20	7.86e-01	-0.035000	8.62e-01
RAB geranylgeranylation	61	6.39e-01	0.034800	7.58e-01
Gap junction trafficking and regulation	32	7.37e-01	0.034300	8.25e-01
Neurotransmitter release cycle	38	7.16e-01	0.034100	8.12e-01
Signaling by ALK fusions and activated point mutants	54	6.66e-01	-0.033900	7.77e-01
Signaling by ALK in cancer	54	6.66e-01	-0.033900	7.77e-01
Unfolded Protein Response (UPR)	92	5.79e-01	-0.033500	7.13e-01
Energy dependent regulation of mTOR by LKB1-AMPK	28	7.60e-01	-0.033300	8.41e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	8.23e-01	-0.033300	8.89e-01
Asparagine N-linked glycosylation	283	3.38e-01	0.033200	5.22e-01
Sema4D in semaphorin signaling	24	7.79e-01	-0.033100	8.56e-01
NIK–>noncanonical NF-kB signaling	57	6.66e-01	0.033100	7.77e-01
Peptide hormone metabolism	59	6.62e-01	0.032900	7.75e-01
Selective autophagy	70	6.35e-01	0.032800	7.55e-01
Termination of O-glycan biosynthesis	14	8.33e-01	-0.032600	8.96e-01
ADORA2B mediated anti-inflammatory cytokines production	36	7.36e-01	0.032500	8.25e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	8.52e-01	0.032500	9.09e-01
SLC-mediated transmembrane transport	173	4.70e-01	0.031900	6.30e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	35	7.48e-01	-0.031400	8.31e-01
Vesicle-mediated transport	626	1.82e-01	-0.031300	3.46e-01
APC/C:Cdc20 mediated degradation of Securin	66	6.62e-01	0.031100	7.75e-01
Organelle biogenesis and maintenance	274	3.77e-01	0.031100	5.56e-01
Aquaporin-mediated transport	37	7.44e-01	-0.031000	8.30e-01
Asymmetric localization of PCP proteins	62	6.77e-01	0.030600	7.82e-01
Glycosphingolipid metabolism	36	7.51e-01	-0.030600	8.33e-01
Golgi-to-ER retrograde transport	123	5.61e-01	0.030300	6.97e-01
Carboxyterminal post-translational modifications of tubulin	30	7.76e-01	-0.030000	8.54e-01
Transport of connexons to the plasma membrane	13	8.52e-01	-0.030000	9.09e-01
Pyroptosis	25	8.02e-01	-0.029000	8.72e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	8.14e-01	0.029000	8.80e-01
SCF-beta-TrCP mediated degradation of Emi1	53	7.16e-01	0.028900	8.12e-01
Ribavirin ADME	10	8.77e-01	0.028300	9.28e-01
Cilium Assembly	187	5.08e-01	0.028100	6.60e-01
L1CAM interactions	104	6.24e-01	-0.027800	7.45e-01
SCF(Skp2)-mediated degradation of p27/p21	60	7.10e-01	0.027800	8.07e-01
Signaling by ERBB4	52	7.29e-01	0.027800	8.21e-01
Metabolism of steroids	123	5.96e-01	-0.027700	7.25e-01
Chaperonin-mediated protein folding	77	6.75e-01	-0.027600	7.82e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	51	7.34e-01	-0.027600	8.23e-01
Glycogen storage diseases	14	8.59e-01	-0.027500	9.12e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	6.87e-01	-0.027500	7.88e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	31	7.93e-01	-0.027200	8.65e-01
MAPK6/MAPK4 signaling	84	6.67e-01	0.027100	7.77e-01
Transcriptional regulation by RUNX3	95	6.48e-01	-0.027100	7.64e-01
Interleukin-37 signaling	20	8.36e-01	-0.026800	8.98e-01
MECP2 regulates neuronal receptors and channels	17	8.48e-01	0.026800	9.07e-01
PERK regulates gene expression	32	7.95e-01	-0.026500	8.66e-01
TNFR2 non-canonical NF-kB pathway	95	6.55e-01	0.026500	7.69e-01
B-WICH complex positively regulates rRNA expression	43	7.64e-01	-0.026500	8.44e-01
mTORC1-mediated signalling	24	8.23e-01	-0.026300	8.89e-01
Constitutive Signaling by Aberrant PI3K in Cancer	63	7.28e-01	-0.025400	8.20e-01
PECAM1 interactions	12	8.83e-01	-0.024600	9.29e-01
Downstream signaling events of B Cell Receptor (BCR)	79	7.06e-01	0.024500	8.05e-01
Post-translational protein modification	1229	1.64e-01	-0.023700	3.19e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	8.45e-01	-0.023600	9.04e-01
Semaphorin interactions	63	7.47e-01	0.023600	8.31e-01
Metabolism of RNA	698	2.94e-01	-0.023400	4.81e-01
Protein localization	157	6.15e-01	0.023300	7.40e-01
Glucagon signaling in metabolic regulation	26	8.38e-01	-0.023200	8.98e-01
TP53 Regulates Metabolic Genes	80	7.23e-01	0.022900	8.16e-01
Dopamine Neurotransmitter Release Cycle	21	8.59e-01	-0.022500	9.12e-01
Sialic acid metabolism	29	8.37e-01	0.022100	8.98e-01
Transcription of the HIV genome	67	7.56e-01	-0.022000	8.37e-01
G alpha (12/13) signalling events	70	7.52e-01	-0.021900	8.33e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	14	8.87e-01	0.021900	9.31e-01
Signaling by FGFR4	33	8.33e-01	-0.021200	8.96e-01
Gap junction assembly	19	8.73e-01	0.021200	9.26e-01
Signaling by ERBB2 ECD mutants	16	8.84e-01	-0.021100	9.29e-01
ER-Phagosome pathway	79	7.48e-01	-0.020900	8.31e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	7.60e-01	-0.020400	8.41e-01
Formation of the cornified envelope	27	8.55e-01	-0.020300	9.10e-01
Keratinization	27	8.55e-01	-0.020300	9.10e-01
Vitamin B5 (pantothenate) metabolism	16	8.88e-01	-0.020300	9.31e-01
SARS-CoV-1 Infection	137	6.82e-01	-0.020300	7.87e-01
Platelet homeostasis	74	7.67e-01	0.020000	8.47e-01
Metabolism	1792	1.65e-01	-0.019900	3.19e-01
Signaling by TGFB family members	114	7.16e-01	-0.019700	8.12e-01
Receptor Mediated Mitophagy	11	9.10e-01	-0.019700	9.49e-01
Sensory processing of sound by outer hair cells of the cochlea	41	8.33e-01	0.019000	8.96e-01
Formation of RNA Pol II elongation complex	56	8.08e-01	-0.018800	8.77e-01
RNA Polymerase II Transcription Elongation	56	8.08e-01	-0.018800	8.77e-01
Phase II - Conjugation of compounds	69	7.93e-01	0.018300	8.65e-01
Defective CFTR causes cystic fibrosis	58	8.10e-01	0.018300	8.77e-01
FGFR2 alternative splicing	24	8.81e-01	0.017600	9.28e-01
MicroRNA (miRNA) biogenesis	25	8.80e-01	-0.017400	9.28e-01
G beta:gamma signalling through CDC42	16	9.05e-01	0.017300	9.46e-01
Signaling by FGFR3	34	8.64e-01	0.016900	9.18e-01
Neddylation	231	6.70e-01	0.016300	7.78e-01
Trafficking of GluR2-containing AMPA receptors	16	9.11e-01	-0.016100	9.49e-01
G1/S DNA Damage Checkpoints	65	8.26e-01	-0.015800	8.92e-01
O-linked glycosylation of mucins	45	8.55e-01	0.015700	9.10e-01
Miscellaneous transport and binding events	22	9.03e-01	-0.015100	9.44e-01
FRS-mediated FGFR4 signaling	14	9.22e-01	0.015100	9.59e-01
Mitochondrial Fatty Acid Beta-Oxidation	35	8.78e-01	0.014900	9.28e-01
Aggrephagy	33	8.85e-01	-0.014600	9.29e-01
Extra-nuclear estrogen signaling	68	8.46e-01	0.013600	9.05e-01
Tryptophan catabolism	11	9.38e-01	0.013500	9.71e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	8.44e-01	0.013500	9.04e-01
RNA Polymerase I Transcription Initiation	47	8.76e-01	0.013200	9.28e-01
NPAS4 regulates expression of target genes	19	9.21e-01	-0.013200	9.58e-01
p75NTR recruits signalling complexes	13	9.35e-01	0.013000	9.69e-01
G alpha (q) signalling events	139	7.93e-01	0.012900	8.65e-01
Regulation of gene expression by Hypoxia-inducible Factor	10	9.44e-01	0.012800	9.74e-01
PCP/CE pathway	89	8.36e-01	0.012700	8.98e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	8.84e-01	-0.012700	9.29e-01
Transport of small molecules	572	6.06e-01	-0.012700	7.34e-01
Signaling by Non-Receptor Tyrosine Kinases	52	8.76e-01	0.012500	9.28e-01
Signaling by PTK6	52	8.76e-01	0.012500	9.28e-01
Cellular responses to stress	703	5.81e-01	-0.012200	7.14e-01
Gap junction trafficking	30	9.08e-01	0.012200	9.48e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	13	9.40e-01	-0.012000	9.72e-01
Defects in vitamin and cofactor metabolism	21	9.25e-01	-0.011900	9.60e-01
Stimuli-sensing channels	81	8.55e-01	-0.011800	9.10e-01
Activation of NF-kappaB in B cells	65	8.81e-01	-0.010700	9.28e-01
Mucopolysaccharidoses	11	9.52e-01	0.010400	9.78e-01
Amine ligand-binding receptors	11	9.53e-01	-0.010200	9.78e-01
Sphingolipid metabolism	76	8.81e-01	-0.009950	9.28e-01
Other semaphorin interactions	19	9.41e-01	0.009760	9.72e-01
Protein folding	83	8.80e-01	-0.009620	9.28e-01
GPCR ligand binding	240	7.98e-01	0.009610	8.69e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	9.51e-01	0.009490	9.77e-01
Cellular responses to stimuli	712	6.72e-01	-0.009340	7.80e-01
Regulation of FZD by ubiquitination	18	9.47e-01	-0.009130	9.75e-01
RNA polymerase II transcribes snRNA genes	71	8.94e-01	0.009120	9.37e-01
Formation of definitive endoderm	11	9.60e-01	0.008750	9.82e-01
Mitochondrial iron-sulfur cluster biogenesis	13	9.57e-01	-0.008720	9.80e-01
Sphingolipid de novo biosynthesis	40	9.24e-01	0.008690	9.60e-01
CDK-mediated phosphorylation and removal of Cdc6	71	9.00e-01	-0.008610	9.42e-01
NRIF signals cell death from the nucleus	16	9.53e-01	0.008510	9.78e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	74	9.09e-01	-0.007680	9.48e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	9.27e-01	-0.007620	9.62e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	9.13e-01	0.007420	9.51e-01
Signaling by NOTCH4	81	9.08e-01	-0.007410	9.48e-01
Constitutive Signaling by Overexpressed ERBB2	11	9.69e-01	0.006670	9.84e-01
ALK mutants bind TKIs	11	9.70e-01	-0.006590	9.84e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	9.48e-01	0.006430	9.75e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	189	8.81e-01	0.006350	9.28e-01
RND1 GTPase cycle	39	9.46e-01	-0.006280	9.75e-01
Formation of annular gap junctions	11	9.72e-01	-0.006210	9.85e-01
Acyl chain remodelling of PE	21	9.61e-01	0.006140	9.83e-01
Synthesis of PIPs at the late endosome membrane	11	9.73e-01	0.005920	9.85e-01
IKK complex recruitment mediated by RIP1	23	9.63e-01	-0.005560	9.84e-01
ROS and RNS production in phagocytes	33	9.57e-01	-0.005380	9.80e-01
p53-Dependent G1 DNA Damage Response	63	9.42e-01	0.005320	9.72e-01
p53-Dependent G1/S DNA damage checkpoint	63	9.42e-01	0.005320	9.72e-01
Signaling by FGFR in disease	53	9.49e-01	-0.005120	9.75e-01
Budding and maturation of HIV virion	28	9.64e-01	-0.004980	9.84e-01
Signaling by NTRK2 (TRKB)	23	9.67e-01	-0.004950	9.84e-01
SHC-mediated cascade:FGFR4	12	9.76e-01	0.004920	9.88e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	9.67e-01	0.004910	9.84e-01
Formation of paraxial mesoderm	62	9.48e-01	0.004770	9.75e-01
Transcriptional regulation of pluripotent stem cells	20	9.73e-01	0.004400	9.85e-01
Adenylate cyclase inhibitory pathway	12	9.80e-01	-0.004100	9.90e-01
Signaling by Hippo	20	9.75e-01	-0.004100	9.87e-01
Intra-Golgi traffic	41	9.65e-01	0.003920	9.84e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	9.67e-01	0.003710	9.84e-01
HIV Transcription Elongation	42	9.67e-01	0.003710	9.84e-01
Tat-mediated elongation of the HIV-1 transcript	42	9.67e-01	0.003710	9.84e-01
Glycogen metabolism	24	9.80e-01	-0.003000	9.90e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	9.85e-01	0.002760	9.93e-01
Late endosomal microautophagy	32	9.79e-01	-0.002730	9.89e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	69	9.69e-01	-0.002670	9.84e-01
Signaling by Receptor Tyrosine Kinases	477	9.28e-01	0.002410	9.62e-01
Mitochondrial calcium ion transport	22	9.86e-01	-0.002220	9.93e-01
E3 ubiquitin ligases ubiquitinate target proteins	48	9.85e-01	-0.001600	9.93e-01
PKA-mediated phosphorylation of CREB	18	9.91e-01	0.001550	9.96e-01
SUMOylation of transcription factors	16	9.92e-01	-0.001510	9.96e-01
Regulation of BACH1 activity	11	9.93e-01	-0.001430	9.97e-01
Negative regulation of FGFR4 signaling	23	9.91e-01	-0.001310	9.96e-01
Xenobiotics	11	9.94e-01	0.001260	9.97e-01
Downstream signaling of activated FGFR4	19	9.93e-01	0.001180	9.97e-01
ABC transporter disorders	71	9.92e-01	0.000710	9.96e-01
Suppression of phagosomal maturation	13	9.96e-01	-0.000709	9.98e-01
Insulin processing	22	9.96e-01	-0.000565	9.98e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	17	9.97e-01	0.000439	9.98e-01
Synthesis of bile acids and bile salts	27	9.98e-01	-0.000317	9.98e-01

---

Detailed Gene set reports

Unwinding of DNA

Unwinding of DNA

	1435
set	Unwinding of DNA
setSize	12
pANOVA	2.76e-05
s.dist	-0.699
p.adjustANOVA	0.000327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM5	-8013
MCM7	-7956
MCM3	-7921
MCM2	-7691
MCM4	-7656
MCM6	-6149
CDC45	-6143
GINS4	-5110
MCM8	-4864
GINS1	-3852
GINS2	-2291
GINS3	2220

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM5	-8013
MCM7	-7956
MCM3	-7921
MCM2	-7691
MCM4	-7656
MCM6	-6149
CDC45	-6143
GINS4	-5110
MCM8	-4864
GINS1	-3852
GINS2	-2291
GINS3	2220

---

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

	236
set	Crosslinking of collagen fibrils
setSize	17
pANOVA	5.81e-06
s.dist	0.635
p.adjustANOVA	8.96e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LOXL4	9998
COL1A1	9761
COL1A2	9718
LOX	9654
BMP1	9420
PCOLCE	9210
LOXL2	8341
TLL2	8197
COL4A5	7782
COL4A1	7641
COL4A2	7098
TLL1	6185
COL4A3	5078
PXDN	4995
LOXL1	1691
LOXL3	1118
COL4A4	-646

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LOXL4	9998
COL1A1	9761
COL1A2	9718
LOX	9654
BMP1	9420
PCOLCE	9210
LOXL2	8341
TLL2	8197
COL4A5	7782
COL4A1	7641
COL4A2	7098
TLL1	6185
COL4A3	5078
PXDN	4995
LOXL1	1691
LOXL3	1118
COL4A4	-646

---

Polo-like kinase mediated events

Polo-like kinase mediated events

	897
set	Polo-like kinase mediated events
setSize	16
pANOVA	2.51e-05
s.dist	-0.608
p.adjustANOVA	0.000302

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PKMYT1	-8147
PLK1	-7811
MYBL2	-7729
EP300	-7576
CDC25A	-7375
FOXM1	-6904
WEE1	-6855
CENPF	-4807
CCNB1	-4474
RBBP4	-3614
CCNB2	-2814
CDC25C	-2510
LIN52	-2243
LIN54	-903
LIN37	-595
LIN9	418

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PKMYT1	-8147
PLK1	-7811
MYBL2	-7729
EP300	-7576
CDC25A	-7375
FOXM1	-6904
WEE1	-6855
CENPF	-4807
CCNB1	-4474
RBBP4	-3614
CCNB2	-2814
CDC25C	-2510
LIN52	-2243
LIN54	-903
LIN37	-595
LIN9	418

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	378
set	Eukaryotic Translation Elongation
setSize	93
pANOVA	1.43e-23
s.dist	0.6
p.adjustANOVA	1.07e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
EEF1A2	9743
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
EEF1A1	8370
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
EEF1A1P5	7871
RPS24	7806
RPS27	7791
RPL41	7774

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
EEF1A2	9743
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
EEF1A1	8370
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
EEF1A1P5	7871
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
EEF1D	6412
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
EEF1B2	6215
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
EEF1G	5974
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
RPL38	2486
EEF2	2334
RPS2	2045
RPS16	389
RPS4Y1	0

---

Interleukin-2 signaling

Interleukin-2 signaling

	606
set	Interleukin-2 signaling
setSize	11
pANOVA	0.000625
s.dist	-0.596
p.adjustANOVA	0.00465

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT5A	-8204
STAT5B	-8185
PTK2B	-7776
IL2RG	-6181
JAK1	-6046
SYK	-5746
JAK3	-4502
LCK	-1659
IL2RB	-1439
SHC1	-602
IL2RA	791

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT5A	-8204
STAT5B	-8185
PTK2B	-7776
IL2RG	-6181
JAK1	-6046
SYK	-5746
JAK3	-4502
LCK	-1659
IL2RB	-1439
SHC1	-602
IL2RA	791

---

Viral mRNA Translation

Viral mRNA Translation

	1447
set	Viral mRNA Translation
setSize	88
pANOVA	4.56e-22
s.dist	0.595
p.adjustANOVA	1.05e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
DNAJC3	9433
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
DNAJC3	9433
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
RPL38	2486
RPS2	2045
GRSF1	1652
RPS16	389
RPS4Y1	0

---

Peptide chain elongation

Peptide chain elongation

	870
set	Peptide chain elongation
setSize	88
pANOVA	4.92e-22
s.dist	0.595
p.adjustANOVA	1.05e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
EEF1A1	8370
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
EEF1A1	8370
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
RPL38	2486
EEF2	2334
RPS2	2045
RPS16	389
RPS4Y1	0

---

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)

	1289
set	Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize	16
pANOVA	3.9e-05
s.dist	-0.594
p.adjustANOVA	0.000438

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DPEP3	-7742
DPEP1	-7172
ALOX15	-6914
DPEP2	-6844
ALOX5	-6838
LTC4S	-5697
MAPKAPK2	-5623
CYP4F3	-5399
ALOX5AP	-4944
CYP4F2	-4881
GGT1	-4851
ABCC1	-3877
LTA4H	-3703
PTGR1	-1308
CYP4B1	514
GGT5	3471

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DPEP3	-7742
DPEP1	-7172
ALOX15	-6914
DPEP2	-6844
ALOX5	-6838
LTC4S	-5697
MAPKAPK2	-5623
CYP4F3	-5399
ALOX5AP	-4944
CYP4F2	-4881
GGT1	-4851
ABCC1	-3877
LTA4H	-3703
PTGR1	-1308
CYP4B1	514
GGT5	3471

---

RIP-mediated NFkB activation via ZBP1

RIP-mediated NFkB activation via ZBP1

	977
set	RIP-mediated NFkB activation via ZBP1
setSize	17
pANOVA	2.49e-05
s.dist	-0.59
p.adjustANOVA	0.000302

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYD88	-7427
NFKB1	-6938
IKBKB	-6522
TICAM1	-6365
RIPK3	-6148
NFKB2	-5928
ZBP1	-5706
IKBKG	-5599
NFKBIB	-5580
NFKBIA	-5293
TLR3	-5038
RIPK1	-4637
NKIRAS2	-4392
DHX9	-3785
CHUK	-323
NKIRAS1	1585
RELA	2346

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYD88	-7427
NFKB1	-6938
IKBKB	-6522
TICAM1	-6365
RIPK3	-6148
NFKB2	-5928
ZBP1	-5706
IKBKG	-5599
NFKBIB	-5580
NFKBIA	-5293
TLR3	-5038
RIPK1	-4637
NKIRAS2	-4392
DHX9	-3785
CHUK	-323
NKIRAS1	1585
RELA	2346

---

Collagen biosynthesis and modifying enzymes

Collagen biosynthesis and modifying enzymes

	211
set	Collagen biosynthesis and modifying enzymes
setSize	63
pANOVA	1.02e-15
s.dist	0.584
p.adjustANOVA	6.94e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL9A1	10116
COL5A1	9892
COL19A1	9860
COL15A1	9858
ADAMTS14	9822
COL27A1	9805
COL1A1	9761
COL22A1	9728
P4HA2	9723
COL1A2	9718
COL6A3	9665
COL3A1	9620
BMP1	9420
COL11A1	9387
COL5A2	9363
P4HA3	9332
SERPINH1	9323
COLGALT2	9322
COL6A2	9292
ADAMTS2	9229

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL9A1	10116
COL5A1	9892
COL19A1	9860
COL15A1	9858
ADAMTS14	9822
COL27A1	9805
COL1A1	9761
COL22A1	9728
P4HA2	9723
COL1A2	9718
COL6A3	9665
COL3A1	9620
BMP1	9420
COL11A1	9387
COL5A2	9363
P4HA3	9332
SERPINH1	9323
COLGALT2	9322
COL6A2	9292
ADAMTS2	9229
PLOD2	9213
PCOLCE	9210
P3H1	9165
COL11A2	9137
COL6A1	9063
P4HA1	9016
COL24A1	8730
COL16A1	8564
COL10A1	8329
PPIB	8226
P3H3	8208
TLL2	8197
PLOD1	8152
COL9A3	7943
COL4A5	7782
COL4A1	7641
P3H2	7515
COL4A2	7098
COL7A1	6775
CRTAP	6386
TLL1	6185
COL4A3	5078
COL13A1	4869
PCOLCE2	4430
COL26A1	4381
COL18A1	4223
COL2A1	3985
COL12A1	3194
COL9A2	2532
COL8A2	2405
PLOD3	2333
COL28A1	2122
ADAMTS3	2028
COL8A1	1977
COL14A1	1974
COL5A3	1620
COL21A1	1435
COL25A1	46
COL4A4	-646
COL17A1	-2066
COLGALT1	-2239
P4HB	-2641
COL23A1	-6881

---

MET activates PTK2 signaling

MET activates PTK2 signaling

	670
set	MET activates PTK2 signaling
setSize	29
pANOVA	5.57e-08
s.dist	0.583
p.adjustANOVA	1.39e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL5A1	9892
COL27A1	9805
COL1A1	9761
COL1A2	9718
COL3A1	9620
COL11A1	9387
COL5A2	9363
FN1	9194
COL11A2	9137
COL24A1	8730
LAMA1	8697
MET	8014
LAMA2	7690
ITGA2	7318
LAMB2	6992
ITGA3	6494
LAMC3	5882
SRC	5632
LAMC1	5322
LAMB1	4376

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL5A1	9892
COL27A1	9805
COL1A1	9761
COL1A2	9718
COL3A1	9620
COL11A1	9387
COL5A2	9363
FN1	9194
COL11A2	9137
COL24A1	8730
LAMA1	8697
MET	8014
LAMA2	7690
ITGA2	7318
LAMB2	6992
ITGA3	6494
LAMC3	5882
SRC	5632
LAMC1	5322
LAMB1	4376
ITGB1	4369
COL2A1	3985
LAMA5	3542
PTK2	2636
LAMA4	2000
COL5A3	1620
LAMB3	1515
HGF	1315
LAMA3	574

---

Interleukin-15 signaling

Interleukin-15 signaling

	603
set	Interleukin-15 signaling
setSize	14
pANOVA	0.000199
s.dist	-0.574
p.adjustANOVA	0.00176

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT5A	-8204
STAT5B	-8185
IL15RA	-7561
GAB2	-7133
GRB2	-6337
IL2RG	-6181
JAK1	-6046
JAK3	-4502
SOS1	-3779
SOS2	-2367
STAT3	-1760
IL2RB	-1439
SHC1	-602
IL15	3793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT5A	-8204
STAT5B	-8185
IL15RA	-7561
GAB2	-7133
GRB2	-6337
IL2RG	-6181
JAK1	-6046
JAK3	-4502
SOS1	-3779
SOS2	-2367
STAT3	-1760
IL2RB	-1439
SHC1	-602
IL15	3793

---

Heme biosynthesis

Heme biosynthesis

	535
set	Heme biosynthesis
setSize	13
pANOVA	0.00034
s.dist	-0.574
p.adjustANOVA	0.00272

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ALAD	-8018
PPOX	-7636
CPOX	-6829
ALAS2	-6737
ALAS1	-6477
FECH	-5846
HMBS	-5648
UROS	-5582
UROD	-5202
COX15	-4730
ABCG2	-2119
FLVCR1	88
COX10	8771

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ALAD	-8018
PPOX	-7636
CPOX	-6829
ALAS2	-6737
ALAS1	-6477
FECH	-5846
HMBS	-5648
UROS	-5582
UROD	-5202
COX15	-4730
ABCG2	-2119
FLVCR1	88
COX10	8771

---

Presynaptic depolarization and calcium channel opening

Presynaptic depolarization and calcium channel opening

	914
set	Presynaptic depolarization and calcium channel opening
setSize	10
pANOVA	0.00178
s.dist	0.57
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CACNA1A	9645
CACNA1E	9547
CACNB1	9339
CACNB4	8941
CACNB2	6648
CACNB3	6357
CACNG2	4152
CACNA2D3	3782
CACNA2D2	2618
CACNA2D1	871

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CACNA1A	9645
CACNA1E	9547
CACNB1	9339
CACNB4	8941
CACNB2	6648
CACNB3	6357
CACNG2	4152
CACNA2D3	3782
CACNA2D2	2618
CACNA2D1	871

---

Anchoring fibril formation

Anchoring fibril formation

	73
set	Anchoring fibril formation
setSize	13
pANOVA	0.000482
s.dist	0.559
p.adjustANOVA	0.00366

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL1A1	9761
COL1A2	9718
BMP1	9420
TLL2	8197
COL4A5	7782
COL4A1	7641
COL4A2	7098
COL7A1	6775
TLL1	6185
COL4A3	5078
LAMB3	1515
LAMA3	574
COL4A4	-646

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL1A1	9761
COL1A2	9718
BMP1	9420
TLL2	8197
COL4A5	7782
COL4A1	7641
COL4A2	7098
COL7A1	6775
TLL1	6185
COL4A3	5078
LAMB3	1515
LAMA3	574
COL4A4	-646

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	380
set	Eukaryotic Translation Termination
setSize	92
pANOVA	9.22e-20
s.dist	0.548
p.adjustANOVA	1.06e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
GSPT2	4458
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
RPL38	2486
ETF1	2191
RPS2	2045
N6AMT1	1204
RPS16	389
TRMT112	340
RPS4Y1	0
GSPT1	-4699
APEH	-6163

---

HDMs demethylate histones

HDMs demethylate histones

	517
set	HDMs demethylate histones
setSize	21
pANOVA	1.45e-05
s.dist	-0.546
p.adjustANOVA	2e-04

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KDM3B	-8140
KDM2B	-7543
PHF8	-7438
KDM4A	-7349
KDM4C	-7265
KDM6B	-6529
JMJD6	-6173
KDM2A	-5465
KDM4B	-5200
PHF2	-5134
KDM1B	-4982
KDM5C	-4830
KDM3A	-3046
KDM7A	-1994
KDM5A	-1805
KDM1A	-1504
KDM5B	-1443
KDM6A	-1231
KDM5D	52
UTY	447

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KDM3B	-8140
KDM2B	-7543
PHF8	-7438
KDM4A	-7349
KDM4C	-7265
KDM6B	-6529
JMJD6	-6173
KDM2A	-5465
KDM4B	-5200
PHF2	-5134
KDM1B	-4982
KDM5C	-4830
KDM3A	-3046
KDM7A	-1994
KDM5A	-1805
KDM1A	-1504
KDM5B	-1443
KDM6A	-1231
KDM5D	52
UTY	447
ARID5B	1495

---

Selenocysteine synthesis

Selenocysteine synthesis

	1164
set	Selenocysteine synthesis
setSize	92
pANOVA	1.54e-19
s.dist	0.545
p.adjustANOVA	1.64e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
RPLP2	4306
RPL8	4187
RPS14	4031
SARS1	3600
RPS21	3511
RPL39L	3183
RPL38	2486
RPS2	2045
SEPSECS	1081
RPS16	389
RPS4Y1	0
PSTK	-981
EEFSEC	-2028
SEPHS2	-2727
SECISBP2	-4428

---

Collagen chain trimerization

Collagen chain trimerization

	212
set	Collagen chain trimerization
setSize	40
pANOVA	2.69e-09
s.dist	0.544
p.adjustANOVA	9.32e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL9A1	10116
COL5A1	9892
COL19A1	9860
COL15A1	9858
COL27A1	9805
COL1A1	9761
COL22A1	9728
COL1A2	9718
COL6A3	9665
COL3A1	9620
COL11A1	9387
COL5A2	9363
COL6A2	9292
COL11A2	9137
COL6A1	9063
COL24A1	8730
COL16A1	8564
COL10A1	8329
COL9A3	7943
COL4A5	7782

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL9A1	10116
COL5A1	9892
COL19A1	9860
COL15A1	9858
COL27A1	9805
COL1A1	9761
COL22A1	9728
COL1A2	9718
COL6A3	9665
COL3A1	9620
COL11A1	9387
COL5A2	9363
COL6A2	9292
COL11A2	9137
COL6A1	9063
COL24A1	8730
COL16A1	8564
COL10A1	8329
COL9A3	7943
COL4A5	7782
COL4A1	7641
COL4A2	7098
COL7A1	6775
COL4A3	5078
COL13A1	4869
COL26A1	4381
COL18A1	4223
COL2A1	3985
COL12A1	3194
COL9A2	2532
COL8A2	2405
COL28A1	2122
COL8A1	1977
COL14A1	1974
COL5A3	1620
COL21A1	1435
COL25A1	46
COL4A4	-646
COL17A1	-2066
COL23A1	-6881

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	424
set	Formation of a pool of free 40S subunits
setSize	100
pANOVA	8.41e-21
s.dist	0.541
p.adjustANOVA	1.4e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
EIF3G	8624
RPL3L	8587
RPL21	8519
EIF3I	8419
RPS27L	8381
RPS10	8342
EIF3E	8311
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
EIF3G	8624
RPL3L	8587
RPL21	8519
EIF3I	8419
RPS27L	8381
RPS10	8342
EIF3E	8311
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
EIF3J	7034
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
EIF3H	6479
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
EIF3M	4553
RPLP2	4306
RPL8	4187
EIF3F	4118
RPS14	4031
EIF3K	3657
EIF1AX	3625
RPS21	3511
EIF3L	3454
RPL39L	3183
RPL38	2486
RPS2	2045
EIF3D	1031
RPS16	389
RPS4Y1	0
EIF3C	-7070
EIF3A	-7086
EIF3B	-7137

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1142
set	SRP-dependent cotranslational protein targeting to membrane
setSize	111
pANOVA	1.08e-22
s.dist	0.538
p.adjustANOVA	5.38e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
SRPRB	9579
SSR2	9318
RPL26L1	9307
SSR3	8797
RPS26	8723
RPL26	8693
RPL3L	8587
TRAM1	8565
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
SRP14	7846
RPS24	7806

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
SRPRB	9579
SSR2	9318
RPL26L1	9307
SSR3	8797
RPS26	8723
RPL26	8693
RPL3L	8587
TRAM1	8565
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
SRP14	7846
RPS24	7806
SEC11A	7795
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
SRP72	7401
RPS17	7351
SSR1	7283
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
SEC61G	6752
RPL30	6732
RPS27A	6559
RPS15	6456
SEC61B	6442
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
SRP19	6122
RPL5	5985
RPN1	5972
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
SRP9	4799
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
SPCS3	4319
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
SSR4	2902
SEC11C	2715
SRP54	2711
RPL38	2486
SEC61A1	2341
RPS2	2045
SPCS2	1336
SPCS1	1300
RPS16	389
RPS4Y1	0
RPN2	-546
DDOST	-952
SRP68	-3515
SRPRA	-4667
SEC61A2	-4831

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	800
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	94
pANOVA	3.35e-19
s.dist	0.534
p.adjustANOVA	3.13e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
NCBP2	5557
RPS29	5226
RPL3	4944
RPSA	4786
NCBP1	4783
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
GSPT2	4458
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
RPL38	2486
ETF1	2191
RPS2	2045
RPS16	389
RPS4Y1	0
EIF4G1	-4149
GSPT1	-4699
PABPC1	-5574
UPF1	-5575

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

	1117
set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	3.03e-08
s.dist	0.533
p.adjustANOVA	7.96e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS26	8723
RPS27L	8381
EEF1A1	8370
RPS10	8342
RPS24	7806
RPS27	7791
RPS3A	7758
RPS18	7754
RPS13	7495
RPS17	7351
RPS8	7213
RPS19	7096
RPS15A	7044
RPS7	6934
FAU	6868
RPS6	6766
RPS27A	6559
RPS15	6456
RPS11	6341
RPS23	6208

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS26	8723
RPS27L	8381
EEF1A1	8370
RPS10	8342
RPS24	7806
RPS27	7791
RPS3A	7758
RPS18	7754
RPS13	7495
RPS17	7351
RPS8	7213
RPS19	7096
RPS15A	7044
RPS7	6934
FAU	6868
RPS6	6766
RPS27A	6559
RPS15	6456
RPS11	6341
RPS23	6208
RPS5	6192
RPS9	6123
RPS4X	5953
RPS20	5909
RPS12	5905
RPS28	5871
RPS29	5226
RPSA	4786
RPS25	4719
RPS3	4690
RPS14	4031
RPS21	3511
RPS2	2045
RPS16	389
RPS4Y1	0
HNRNPA1	-2260

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1102
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	100
pANOVA	1.64e-19
s.dist	0.523
p.adjustANOVA	1.64e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
CEBPG	8985
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
DDIT3	8048
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
CEBPG	8985
RPS26	8723
RPL26	8693
RPL3L	8587
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
DDIT3	8048
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
EIF2S1	5261
RPS29	5226
ATF4	4959
RPL3	4944
EIF2S2	4811
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
RPLP2	4306
RPL8	4187
RPS14	4031
RPS21	3511
RPL39L	3183
EIF2AK4	2669
RPL38	2486
ATF2	2077
RPS2	2045
IMPACT	1986
RPS16	389
ATF3	125
RPS4Y1	0
ASNS	-85
EIF2S3	-1947
GCN1	-4395
CEBPB	-4660
TRIB3	-6640

---

Transcription of E2F targets under negative control by DREAM complex

Transcription of E2F targets under negative control by DREAM complex

	1376
set	Transcription of E2F targets under negative control by DREAM complex
setSize	19
pANOVA	8.05e-05
s.dist	-0.522
p.adjustANOVA	0.000793

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYC	-8093
E2F1	-7970
CDC25A	-7375
E2F4	-7235
HDAC1	-6902
MAX	-6533
CDC6	-6254
TFDP2	-5482
TFDP1	-5272
PCNA	-3923
RBL2	-3872
RBBP4	-3614
TOP2A	-3235
LIN52	-2243
RBL1	-2207
LIN54	-903
LIN37	-595
LIN9	418
E2F5	8483

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYC	-8093
E2F1	-7970
CDC25A	-7375
E2F4	-7235
HDAC1	-6902
MAX	-6533
CDC6	-6254
TFDP2	-5482
TFDP1	-5272
PCNA	-3923
RBL2	-3872
RBBP4	-3614
TOP2A	-3235
LIN52	-2243
RBL1	-2207
LIN54	-903
LIN37	-595
LIN9	418
E2F5	8483

---

G0 and Early G1

G0 and Early G1

	450
set	G0 and Early G1
setSize	27
pANOVA	2.76e-06
s.dist	-0.521
p.adjustANOVA	4.8e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYC	-8093
E2F1	-7970
MYBL2	-7729
CDC25A	-7375
E2F4	-7235
HDAC1	-6902
CDK2	-6584
MAX	-6533
CCNE1	-6350
CDC6	-6254
TFDP2	-5482
TFDP1	-5272
PCNA	-3923
RBL2	-3872
RBBP4	-3614
TOP2A	-3235
DYRK1A	-2995
CCNA2	-2857
CCNE2	-2269
LIN52	-2243

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYC	-8093
E2F1	-7970
MYBL2	-7729
CDC25A	-7375
E2F4	-7235
HDAC1	-6902
CDK2	-6584
MAX	-6533
CCNE1	-6350
CDC6	-6254
TFDP2	-5482
TFDP1	-5272
PCNA	-3923
RBL2	-3872
RBBP4	-3614
TOP2A	-3235
DYRK1A	-2995
CCNA2	-2857
CCNE2	-2269
LIN52	-2243
RBL1	-2207
CDK1	-2110
LIN54	-903
LIN37	-595
LIN9	418
CCNA1	617
E2F5	8483

---

Collagen formation

Collagen formation

	214
set	Collagen formation
setSize	83
pANOVA	5.03e-16
s.dist	0.515
p.adjustANOVA	3.58e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL9A1	10116
LOXL4	9998
COL5A1	9892
COL19A1	9860
COL15A1	9858
ADAMTS14	9822
COL27A1	9805
COL1A1	9761
COL22A1	9728
P4HA2	9723
COL1A2	9718
COL6A3	9665
LOX	9654
COL3A1	9620
MMP13	9525
BMP1	9420
COL11A1	9387
COL5A2	9363
P4HA3	9332
SERPINH1	9323

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL9A1	10116
LOXL4	9998
COL5A1	9892
COL19A1	9860
COL15A1	9858
ADAMTS14	9822
COL27A1	9805
COL1A1	9761
COL22A1	9728
P4HA2	9723
COL1A2	9718
COL6A3	9665
LOX	9654
COL3A1	9620
MMP13	9525
BMP1	9420
COL11A1	9387
COL5A2	9363
P4HA3	9332
SERPINH1	9323
COLGALT2	9322
COL6A2	9292
ADAMTS2	9229
PLOD2	9213
PCOLCE	9210
P3H1	9165
COL11A2	9137
COL6A1	9063
P4HA1	9016
COL24A1	8730
COL16A1	8564
LOXL2	8341
COL10A1	8329
PPIB	8226
P3H3	8208
TLL2	8197
PLOD1	8152
DST	8150
COL9A3	7943
COL4A5	7782
COL4A1	7641
P3H2	7515
COL4A2	7098
COL7A1	6775
MMP3	6741
MMP9	6641
CRTAP	6386
TLL1	6185
ITGB4	5254
COL4A3	5078
PXDN	4995
COL13A1	4869
PCOLCE2	4430
COL26A1	4381
COL18A1	4223
COL2A1	3985
COL12A1	3194
COL9A2	2532
COL8A2	2405
PLOD3	2333
COL28A1	2122
ADAMTS3	2028
COL8A1	1977
COL14A1	1974
LOXL1	1691
ITGA6	1633
COL5A3	1620
LAMB3	1515
PLEC	1478
COL21A1	1435
CTSS	1338
LOXL3	1118
LAMA3	574
COL25A1	46
CTSB	-633
COL4A4	-646
CTSL	-1207
CD151	-1804
COL17A1	-2066
CTSV	-2163
COLGALT1	-2239
P4HB	-2641
COL23A1	-6881

---

ECM proteoglycans

ECM proteoglycans

	344
set	ECM proteoglycans
setSize	66
pANOVA	4.7e-13
s.dist	0.515
p.adjustANOVA	2.51e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL9A1	10116
HAPLN1	10055
COL5A1	9892
COL1A1	9761
COL1A2	9718
TNR	9692
COL6A3	9665
BGN	9635
COL3A1	9620
FMOD	9505
SPARC	9498
ACAN	9402
COL5A2	9363
IBSP	9301
COL6A2	9292
FN1	9194
DCN	9138
TNN	9123
COL6A1	9063
LUM	8828

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL9A1	10116
HAPLN1	10055
COL5A1	9892
COL1A1	9761
COL1A2	9718
TNR	9692
COL6A3	9665
BGN	9635
COL3A1	9620
FMOD	9505
SPARC	9498
ACAN	9402
COL5A2	9363
IBSP	9301
COL6A2	9292
FN1	9194
DCN	9138
TNN	9123
COL6A1	9063
LUM	8828
SERPINE1	8782
MATN4	8725
LAMA1	8697
TGFB3	8581
LRP4	8297
COMP	8230
ASPN	8111
COL9A3	7943
MATN3	7868
COL4A5	7782
LAMA2	7690
COL4A1	7641
HSPG2	7412
ITGA2	7318
COL4A2	7098
LAMB2	6992
ITGAV	6923
TGFB2	6837
TNC	6675
TNXB	6286
APP	5695
LAMC1	5322
ITGB5	5095
COL4A3	5078
DMP1	4962
LAMB1	4376
ITGB1	4369
COL2A1	3985
AGRN	3555
LAMA5	3542
COL9A2	2532
PTPRS	2450
LAMA4	2000
NCAM1	1655
COL5A3	1620
DAG1	1565
VCAN	952
LAMA3	574
COL4A4	-646
TGFB1	-991
ITGA8	-1576
ITGA9	-2761
ITGB3	-2968
ITGA7	-5093
ITGAX	-7127
ITGA2B	-8114

---

Assembly of collagen fibrils and other multimeric structures

Assembly of collagen fibrils and other multimeric structures

	94
set	Assembly of collagen fibrils and other multimeric structures
setSize	55
pANOVA	6.18e-11
s.dist	0.51
p.adjustANOVA	2.64e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL9A1	10116
LOXL4	9998
COL5A1	9892
COL15A1	9858
COL27A1	9805
COL1A1	9761
COL1A2	9718
COL6A3	9665
LOX	9654
COL3A1	9620
MMP13	9525
BMP1	9420
COL11A1	9387
COL5A2	9363
COL6A2	9292
PCOLCE	9210
COL11A2	9137
COL6A1	9063
COL24A1	8730
LOXL2	8341

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL9A1	10116
LOXL4	9998
COL5A1	9892
COL15A1	9858
COL27A1	9805
COL1A1	9761
COL1A2	9718
COL6A3	9665
LOX	9654
COL3A1	9620
MMP13	9525
BMP1	9420
COL11A1	9387
COL5A2	9363
COL6A2	9292
PCOLCE	9210
COL11A2	9137
COL6A1	9063
COL24A1	8730
LOXL2	8341
COL10A1	8329
TLL2	8197
DST	8150
COL9A3	7943
COL4A5	7782
COL4A1	7641
COL4A2	7098
COL7A1	6775
MMP3	6741
MMP9	6641
TLL1	6185
ITGB4	5254
COL4A3	5078
PXDN	4995
COL18A1	4223
COL2A1	3985
COL12A1	3194
COL9A2	2532
COL8A2	2405
COL8A1	1977
COL14A1	1974
LOXL1	1691
ITGA6	1633
COL5A3	1620
LAMB3	1515
PLEC	1478
CTSS	1338
LOXL3	1118
LAMA3	574
CTSB	-633
COL4A4	-646
CTSL	-1207
CD151	-1804
COL17A1	-2066
CTSV	-2163

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	472
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	111
pANOVA	5.65e-20
s.dist	0.502
p.adjustANOVA	7.04e-18

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
EIF3G	8624
RPL3L	8587
RPL21	8519
EIF3I	8419
RPS27L	8381
RPS10	8342
EIF3E	8311
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
EIF3G	8624
RPL3L	8587
RPL21	8519
EIF3I	8419
RPS27L	8381
RPS10	8342
EIF3E	8311
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
EIF3J	7034
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
EIF5B	6749
RPL30	6732
RPS27A	6559
EIF3H	6479
RPS15	6456
UBA52	6399
EIF4A2	6398
EIF4E	6391
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
EIF2S1	5261
RPS29	5226
RPL3	4944
EIF2S2	4811
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
EIF4A1	4595
EIF3M	4553
EIF5	4454
RPLP2	4306
RPL8	4187
EIF3F	4118
RPS14	4031
EIF3K	3657
EIF1AX	3625
RPS21	3511
EIF3L	3454
RPL39L	3183
RPL38	2486
RPS2	2045
EIF3D	1031
RPS16	389
RPS4Y1	0
EIF2S3	-1947
EIF4B	-2021
EIF4G1	-4149
EIF4H	-5010
EIF3C	-7070
EIF3A	-7086
EIF3B	-7137

---

ZBP1(DAI) mediated induction of type I IFNs

ZBP1(DAI) mediated induction of type I IFNs

	1462
set	ZBP1(DAI) mediated induction of type I IFNs
setSize	20
pANOVA	0.000104
s.dist	-0.501
p.adjustANOVA	0.000995

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYD88	-7427
NFKB1	-6938
IKBKB	-6522
TICAM1	-6365
RIPK3	-6148
NFKB2	-5928
ZBP1	-5706
IKBKG	-5599
NFKBIB	-5580
NFKBIA	-5293
TLR3	-5038
RIPK1	-4637
NKIRAS2	-4392
DHX9	-3785
IRF3	-3679
DTX4	-1807
CHUK	-323
NKIRAS1	1585
RELA	2346
TBK1	8471

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYD88	-7427
NFKB1	-6938
IKBKB	-6522
TICAM1	-6365
RIPK3	-6148
NFKB2	-5928
ZBP1	-5706
IKBKG	-5599
NFKBIB	-5580
NFKBIA	-5293
TLR3	-5038
RIPK1	-4637
NKIRAS2	-4392
DHX9	-3785
IRF3	-3679
DTX4	-1807
CHUK	-323
NKIRAS1	1585
RELA	2346
TBK1	8471

---

CS/DS degradation

CS/DS degradation

	145
set	CS/DS degradation
setSize	11
pANOVA	0.00399
s.dist	0.501
p.adjustANOVA	0.0206

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BGN	9635
DCN	9138
CSPG4	8606
ARSB	8045
IDS	7895
HYAL1	7642
HEXB	5916
HEXA	2769
IDUA	1673
VCAN	952
HYAL3	-1162

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BGN	9635
DCN	9138
CSPG4	8606
ARSB	8045
IDS	7895
HYAL1	7642
HEXB	5916
HEXA	2769
IDUA	1673
VCAN	952
HYAL3	-1162

---

CD22 mediated BCR regulation

CD22 mediated BCR regulation

	130
set	CD22 mediated BCR regulation
setSize	12
pANOVA	0.00269
s.dist	-0.5
p.adjustANOVA	0.0151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGHD	-8074
IGLC3	-7821
PTPN6	-6982
IGHM	-6030
CD22	-4521
CD79B	-4164
LYN	-2400
IGLC1	-2396
IGLC2	-2287
CD79A	-1648
IGKC	718
IGLC7	2041

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGHD	-8074
IGLC3	-7821
PTPN6	-6982
IGHM	-6030
CD22	-4521
CD79B	-4164
LYN	-2400
IGLC1	-2396
IGLC2	-2287
CD79A	-1648
IGKC	718
IGLC7	2041

---

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects

	25
set	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
setSize	17
pANOVA	0.00038
s.dist	-0.498
p.adjustANOVA	0.00298

Top enriched genes

Top 20 genes

GeneID	Gene Rank
E2F2	-8116
E2F1	-7970
CCND3	-7562
E2F3	-6828
CDK2	-6584
CCNE1	-6350
TFDP2	-5482
TFDP1	-5272
CDKN1B	-4772
CCND2	-4689
CDKN1C	-4494
CCNE2	-2269
CDK6	-2151
RB1	-25
CCND1	1617
CDK4	4272
CDKN1A	5371

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
E2F2	-8116
E2F1	-7970
CCND3	-7562
E2F3	-6828
CDK2	-6584
CCNE1	-6350
TFDP2	-5482
TFDP1	-5272
CDKN1B	-4772
CCND2	-4689
CDKN1C	-4494
CCNE2	-2269
CDK6	-2151
RB1	-25
CCND1	1617
CDK4	4272
CDKN1A	5371

---

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)

	282
set	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
setSize	17
pANOVA	0.00038
s.dist	-0.498
p.adjustANOVA	0.00298

Top enriched genes

Top 20 genes

GeneID	Gene Rank
E2F2	-8116
E2F1	-7970
CCND3	-7562
E2F3	-6828
CDK2	-6584
CCNE1	-6350
TFDP2	-5482
TFDP1	-5272
CDKN1B	-4772
CCND2	-4689
CDKN1C	-4494
CCNE2	-2269
CDK6	-2151
RB1	-25
CCND1	1617
CDK4	4272
CDKN1A	5371

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
E2F2	-8116
E2F1	-7970
CCND3	-7562
E2F3	-6828
CDK2	-6584
CCNE1	-6350
TFDP2	-5482
TFDP1	-5272
CDKN1B	-4772
CCND2	-4689
CDKN1C	-4494
CCNE2	-2269
CDK6	-2151
RB1	-25
CCND1	1617
CDK4	4272
CDKN1A	5371

---

Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation

	1041
set	Regulation of FOXO transcriptional activity by acetylation
setSize	10
pANOVA	0.00665
s.dist	-0.496
p.adjustANOVA	0.0302

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EP300	-7576
FOXO4	-7359
TXNIP	-6618
FOXO3	-6492
CREBBP	-6222
KAT2B	-4824
SIRT3	-4576
SIRT1	-4264
TXN	5939
FOXO1	6108

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EP300	-7576
FOXO4	-7359
TXNIP	-6618
FOXO3	-6492
CREBBP	-6222
KAT2B	-4824
SIRT3	-4576
SIRT1	-4264
TXN	5939
FOXO1	6108

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	637
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	110
pANOVA	5.31e-19
s.dist	0.491
p.adjustANOVA	4.67e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
EIF3G	8624
RPL3L	8587
RPL21	8519
EIF3I	8419
RPS27L	8381
RPS10	8342
EIF3E	8311
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	9826
RPL26L1	9307
RPS26	8723
RPL26	8693
EIF3G	8624
RPL3L	8587
RPL21	8519
EIF3I	8419
RPS27L	8381
RPS10	8342
EIF3E	8311
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
RPS17	7351
RPL29	7279
RPS8	7213
RPS19	7096
RPS15A	7044
EIF3J	7034
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
RPL30	6732
RPS27A	6559
EIF3H	6479
RPS15	6456
UBA52	6399
EIF4A2	6398
EIF4E	6391
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
EIF2S1	5261
RPS29	5226
RPL3	4944
EIF2S2	4811
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
EIF4A1	4595
EIF3M	4553
RPLP2	4306
RPL8	4187
EIF3F	4118
RPS14	4031
EIF3K	3657
EIF1AX	3625
RPS21	3511
EIF3L	3454
RPL39L	3183
RPL38	2486
RPS2	2045
EIF3D	1031
RPS16	389
RPS4Y1	0
EIF2S3	-1947
EIF4B	-2021
EIF4G1	-4149
EIF4H	-5010
PABPC1	-5574
EIF3C	-7070
EIF3A	-7086
EIF3B	-7137

---

Interleukin receptor SHC signaling

Interleukin receptor SHC signaling

	597
set	Interleukin receptor SHC signaling
setSize	23
pANOVA	4.62e-05
s.dist	-0.491
p.adjustANOVA	0.000498

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CSF2RA	-8118
IL3RA	-7851
INPP5D	-7719
PIK3CD	-7473
GAB2	-7133
CSF2RB	-6994
PTPN6	-6982
PIK3R2	-6500
GRB2	-6337
IL2RG	-6181
JAK1	-6046
JAK3	-4502
SOS1	-3779
PIK3CB	-3204
INPPL1	-2043
IL2RB	-1439
SHC1	-602
PIK3R1	-172
IL5RA	285
IL2RA	791

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CSF2RA	-8118
IL3RA	-7851
INPP5D	-7719
PIK3CD	-7473
GAB2	-7133
CSF2RB	-6994
PTPN6	-6982
PIK3R2	-6500
GRB2	-6337
IL2RG	-6181
JAK1	-6046
JAK3	-4502
SOS1	-3779
PIK3CB	-3204
INPPL1	-2043
IL2RB	-1439
SHC1	-602
PIK3R1	-172
IL5RA	285
IL2RA	791
JAK2	2478
PIK3R3	2872
PIK3CA	5237

---

Growth hormone receptor signaling

Growth hormone receptor signaling

	511
set	Growth hormone receptor signaling
setSize	20
pANOVA	0.000159
s.dist	-0.488
p.adjustANOVA	0.00145

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IRS2	-8212
STAT5A	-8204
STAT5B	-8185
CISH	-7900
SOCS1	-7875
PTPN6	-6982
STAT1	-6929
MAPK1	-6528
PTPN1	-5566
GHR	-4888
SOCS2	-3683
SH2B1	-3303
MAPK3	-2796
LYN	-2400
STAT3	-1760
SOCS3	809
PRLR	1032
JAK2	2478
ADAM17	3606
IRS1	6996

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IRS2	-8212
STAT5A	-8204
STAT5B	-8185
CISH	-7900
SOCS1	-7875
PTPN6	-6982
STAT1	-6929
MAPK1	-6528
PTPN1	-5566
GHR	-4888
SOCS2	-3683
SH2B1	-3303
MAPK3	-2796
LYN	-2400
STAT3	-1760
SOCS3	809
PRLR	1032
JAK2	2478
ADAM17	3606
IRS1	6996

---

STAT5 activation downstream of FLT3 ITD mutants

STAT5 activation downstream of FLT3 ITD mutants

	1144
set	STAT5 activation downstream of FLT3 ITD mutants
setSize	10
pANOVA	0.00762
s.dist	-0.487
p.adjustANOVA	0.0335

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAT5A	-8204
STAT5B	-8185
PIM1	-7646
GAB2	-7133
FLT3	-6953
GRB2	-6337
BCL2L1	-6051
PTPN11	2003
CDKN1A	5371
NOX4	8011

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAT5A	-8204
STAT5B	-8185
PIM1	-7646
GAB2	-7133
FLT3	-6953
GRB2	-6337
BCL2L1	-6051
PTPN11	2003
CDKN1A	5371
NOX4	8011

---

G1/S-Specific Transcription

G1/S-Specific Transcription

	454
set	G1/S-Specific Transcription
setSize	29
pANOVA	6.08e-06
s.dist	-0.485
p.adjustANOVA	9.28e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
E2F1	-7970
CDT1	-7655
CDC25A	-7375
E2F4	-7235
HDAC1	-6902
CCNE1	-6350
CDC6	-6254
CDC45	-6143
TK1	-6104
ORC1	-6057
TFDP2	-5482
TFDP1	-5272
RRM2	-5194
TYMS	-4721
PCNA	-3923
RBL2	-3872
RBBP4	-3614
FBXO5	-3407
POLA1	-2341
DHFR	-2332

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
E2F1	-7970
CDT1	-7655
CDC25A	-7375
E2F4	-7235
HDAC1	-6902
CCNE1	-6350
CDC6	-6254
CDC45	-6143
TK1	-6104
ORC1	-6057
TFDP2	-5482
TFDP1	-5272
RRM2	-5194
TYMS	-4721
PCNA	-3923
RBL2	-3872
RBBP4	-3614
FBXO5	-3407
POLA1	-2341
DHFR	-2332
LIN52	-2243
RBL1	-2207
CDK1	-2110
LIN54	-903
LIN37	-595
LIN9	418
CCNA1	617
E2F6	5567
E2F5	8483

---

Metabolism of porphyrins

Metabolism of porphyrins

	701
set	Metabolism of porphyrins
setSize	21
pANOVA	0.000142
s.dist	-0.48
p.adjustANOVA	0.00132

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ALAD	-8018
PPOX	-7636
CPOX	-6829
ALAS2	-6737
ALAS1	-6477
FECH	-5846
GUSB	-5740
HMBS	-5648
UROS	-5582
UROD	-5202
COX15	-4730
BLVRB	-4369
BLVRA	-4188
ABCC1	-3877
ABCG2	-2119
ABCC2	-1896
SLCO2B1	-1138
HMOX1	-422
FLVCR1	88
HMOX2	5397

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ALAD	-8018
PPOX	-7636
CPOX	-6829
ALAS2	-6737
ALAS1	-6477
FECH	-5846
GUSB	-5740
HMBS	-5648
UROS	-5582
UROD	-5202
COX15	-4730
BLVRB	-4369
BLVRA	-4188
ABCC1	-3877
ABCG2	-2119
ABCC2	-1896
SLCO2B1	-1138
HMOX1	-422
FLVCR1	88
HMOX2	5397
COX10	8771

---

FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes

	401
set	FOXO-mediated transcription of cell death genes
setSize	16
pANOVA	0.000903
s.dist	-0.479
p.adjustANOVA	0.00628

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CITED2	-8113
STK11	-7774
EP300	-7576
FOXO4	-7359
BCL2L11	-7220
FOXO3	-6492
CREBBP	-6222
NFYC	-6019
BCL6	-5813
NFYA	-5571
BBC3	-3040
FASLG	192
NFYB	438
PINK1	1424
FOXO1	6108
DDIT3	8048

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CITED2	-8113
STK11	-7774
EP300	-7576
FOXO4	-7359
BCL2L11	-7220
FOXO3	-6492
CREBBP	-6222
NFYC	-6019
BCL6	-5813
NFYA	-5571
BBC3	-3040
FASLG	192
NFYB	438
PINK1	1424
FOXO1	6108
DDIT3	8048

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

	53
set	Activation of the pre-replicative complex
setSize	32
pANOVA	2.94e-06
s.dist	-0.477
p.adjustANOVA	5.06e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM5	-8013
POLE	-7958
MCM7	-7956
MCM3	-7921
POLA2	-7880
MCM2	-7691
MCM4	-7656
CDT1	-7655
RPA1	-7556
MCM10	-6987
CDK2	-6584
CDC6	-6254
ORC2	-6244
MCM6	-6149
CDC45	-6143
ORC1	-6057
MCM8	-4864
RPA2	-3955
CDC7	-3047
POLA1	-2341

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM5	-8013
POLE	-7958
MCM7	-7956
MCM3	-7921
POLA2	-7880
MCM2	-7691
MCM4	-7656
CDT1	-7655
RPA1	-7556
MCM10	-6987
CDK2	-6584
CDC6	-6254
ORC2	-6244
MCM6	-6149
CDC45	-6143
ORC1	-6057
MCM8	-4864
RPA2	-3955
CDC7	-3047
POLA1	-2341
GMNN	-1833
ORC3	-1095
POLE3	-652
DBF4	-241
PRIM1	-82
POLE4	659
PRIM2	1636
RPA3	2073
POLE2	2479
ORC4	3573
ORC6	4341
ORC5	8733

---

DNA strand elongation

DNA strand elongation

	264
set	DNA strand elongation
setSize	32
pANOVA	3.01e-06
s.dist	-0.477
p.adjustANOVA	5.08e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LIG1	-8070
MCM5	-8013
MCM7	-7956
MCM3	-7921
POLA2	-7880
MCM2	-7691
MCM4	-7656
RPA1	-7556
POLD1	-7447
FEN1	-6786
MCM6	-6149
CDC45	-6143
GINS4	-5110
MCM8	-4864
RPA2	-3955
PCNA	-3923
GINS1	-3852
RFC3	-3506
RFC5	-3133
RFC4	-2420

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LIG1	-8070
MCM5	-8013
MCM7	-7956
MCM3	-7921
POLA2	-7880
MCM2	-7691
MCM4	-7656
RPA1	-7556
POLD1	-7447
FEN1	-6786
MCM6	-6149
CDC45	-6143
GINS4	-5110
MCM8	-4864
RPA2	-3955
PCNA	-3923
GINS1	-3852
RFC3	-3506
RFC5	-3133
RFC4	-2420
POLA1	-2341
GINS2	-2291
RFC2	-1123
DNA2	-410
PRIM1	-82
POLD3	410
PRIM2	1636
RPA3	2073
GINS3	2220
POLD4	2963
POLD2	3884
RFC1	3910

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1163
set	Selenoamino acid metabolism
setSize	114
pANOVA	1.41e-18
s.dist	0.477
p.adjustANOVA	1.17e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PAPSS2	10045
RPL9	9826
RARS1	9464
RPL26L1	9307
EPRS1	8981
RPS26	8723
RPL26	8693
RPL3L	8587
LARS1	8561
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PAPSS2	10045
RPL9	9826
RARS1	9464
RPL26L1	9307
EPRS1	8981
RPS26	8723
RPL26	8693
RPL3L	8587
LARS1	8561
RPL21	8519
RPS27L	8381
RPS10	8342
RPL13A	8258
RPL35	8127
RPL18A	8091
RPL31	8080
RPL23A	8039
RPL17	8019
RPS24	7806
RPS27	7791
RPL41	7774
RPS3A	7758
RPS18	7754
RPL24	7613
RPL10	7526
RPL34	7508
RPS13	7495
RPL35A	7446
RPL15	7433
IARS1	7373
RPS17	7351
RPL29	7279
RPS8	7213
AIMP1	7111
RPS19	7096
RPS15A	7044
RPL4	6976
RPS7	6934
RPL7	6914
RPL32	6902
RPL7A	6894
FAU	6868
RPL36	6858
RPLP0	6853
RPL27A	6832
RPS6	6766
RPL39	6761
RPL37	6754
EEF1E1	6751
RPL30	6732
RPS27A	6559
RPS15	6456
UBA52	6399
RPL12	6382
RPL10A	6364
RPL36AL	6362
RPS11	6341
RPL18	6326
RPL13	6313
RPL23	6273
RPL27	6245
RPL14	6218
RPS23	6208
RPS5	6192
RPL11	6138
RPL22L1	6129
RPS9	6123
RPL5	5985
RPS4X	5953
RPL37A	5927
RPS20	5909
RPS12	5905
RPLP1	5894
RPS28	5871
RPL19	5824
RPL6	5800
RPL22	5577
RPS29	5226
RPL3	4944
RPSA	4786
RPS25	4719
RPL28	4699
RPS3	4690
RPL36A	4660
SCLY	4419
PAPSS1	4388
RPLP2	4306
AIMP2	4265
RPL8	4187
RPS14	4031
CBS	3668
SARS1	3600
KARS1	3590
RPS21	3511
NNMT	3459
RPL39L	3183
RPL38	2486
DARS1	2058
RPS2	2045
SEPSECS	1081
QARS1	910
RPS16	389
RPS4Y1	0
PSTK	-981
EEFSEC	-2028
SEPHS2	-2727
TXNRD1	-2936
CTH	-3175
HNMT	-3330
AHCY	-3383
INMT	-4211
SECISBP2	-4428
MARS1	-4536
GSR	-4707

---

Regulation of TP53 Activity through Acetylation

Regulation of TP53 Activity through Acetylation

	1064
set	Regulation of TP53 Activity through Acetylation
setSize	29
pANOVA	9.28e-06
s.dist	-0.476
p.adjustANOVA	0.000135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BRD1	-7767
EP300	-7576
MTA2	-7502
ING5	-7428
AKT2	-7321
HDAC1	-6902
BRPF1	-6490
PIP4K2A	-6208
BRPF3	-6032
RBBP7	-5568
PML	-5369
GATAD2B	-5169
KAT6A	-4999
GATAD2A	-4988
CHD3	-4546
BRD7	-4416
TP53	-4019
CHD4	-3662
RBBP4	-3614
AKT1	-3159

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BRD1	-7767
EP300	-7576
MTA2	-7502
ING5	-7428
AKT2	-7321
HDAC1	-6902
BRPF1	-6490
PIP4K2A	-6208
BRPF3	-6032
RBBP7	-5568
PML	-5369
GATAD2B	-5169
KAT6A	-4999
GATAD2A	-4988
CHD3	-4546
BRD7	-4416
TP53	-4019
CHD4	-3662
RBBP4	-3614
AKT1	-3159
PIN1	-2714
PIP4K2B	-2581
MBD3	-1796
PIP4K2C	-1647
HDAC2	1522
ING2	4038
MAP2K6	4121
MEAF6	5588
AKT3	7601

---

NCAM1 interactions

NCAM1 interactions

	748
set	NCAM1 interactions
setSize	33
pANOVA	2.45e-06
s.dist	0.474
p.adjustANOVA	4.31e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COL9A1	10116
COL5A1	9892
COL6A3	9665
COL3A1	9620
CACNA1D	9440
COL5A2	9363
CACNB1	9339
COL6A2	9292
COL6A1	9063
CACNB4	8941
ST8SIA4	8027
COL9A3	7943
COL4A5	7782
COL4A1	7641
COL4A2	7098
CACNB2	6648
CACNB3	6357
PRNP	5919
CACNA1C	5798
COL4A3	5078

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COL9A1	10116
COL5A1	9892
COL6A3	9665
COL3A1	9620
CACNA1D	9440
COL5A2	9363
CACNB1	9339
COL6A2	9292
COL6A1	9063
CACNB4	8941
ST8SIA4	8027
COL9A3	7943
COL4A5	7782
COL4A1	7641
COL4A2	7098
CACNB2	6648
CACNB3	6357
PRNP	5919
CACNA1C	5798
COL4A3	5078
CACNA1H	5021
CACNA1S	4650
COL2A1	3985
AGRN	3555
COL9A2	2532
NCAM1	1655
COL5A3	1620
PSPN	1413
CACNA1G	-42
COL4A4	-646
GFRA2	-3158
GFRA1	-3766
CACNA1I	-4973

---

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

	1332
set	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
setSize	17
pANOVA	0.000775
s.dist	-0.471
p.adjustANOVA	0.00557

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EP300	-7576
E2F4	-7235
GADD45A	-7024
CARM1	-6369
AURKA	-5913
TFDP2	-5482
TFDP1	-5272
CCNB1	-4474
TP53	-4019
PCNA	-3923
RBL2	-3872
CDC25C	-2510
RBL1	-2207
CDK1	-2110
ZNF385A	2376
BAX	2744
PRMT1	5748

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EP300	-7576
E2F4	-7235
GADD45A	-7024
CARM1	-6369
AURKA	-5913
TFDP2	-5482
TFDP1	-5272
CCNB1	-4474
TP53	-4019
PCNA	-3923
RBL2	-3872
CDC25C	-2510
RBL1	-2207
CDK1	-2110
ZNF385A	2376
BAX	2744
PRMT1	5748

---

Diseases associated with glycosaminoglycan metabolism

Diseases associated with glycosaminoglycan metabolism

	310
set	Diseases associated with glycosaminoglycan metabolism
setSize	36
pANOVA	1.17e-06
s.dist	0.468
p.adjustANOVA	2.3e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CHST6	10097
PAPSS2	10045
OGN	10020
BGN	9635
GPC1	9526
FMOD	9505
ACAN	9402
SLC26A2	9355
SDC2	9299
DCN	9138
LUM	8828
CSPG4	8606
EXT1	8362
CHST3	8189
OMD	8092
SDC4	7956
GPC6	7737
HSPG2	7412
PRELP	7176
HEXB	5916

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CHST6	10097
PAPSS2	10045
OGN	10020
BGN	9635
GPC1	9526
FMOD	9505
ACAN	9402
SLC26A2	9355
SDC2	9299
DCN	9138
LUM	8828
CSPG4	8606
EXT1	8362
CHST3	8189
OMD	8092
SDC4	7956
GPC6	7737
HSPG2	7412
PRELP	7176
HEXB	5916
EXT2	5907
AGRN	3555
CHST14	3267
GPC4	2800
HEXA	2769
B3GALT6	2206
B4GALT7	1533
VCAN	952
SDC1	757
B3GAT3	605
ST3GAL3	563
GPC2	108
B4GALT1	-261
SDC3	-1859
CHSY1	-2775
GPC3	-5602

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.2.1             GGally_2.1.2               
##  [3] beeswarm_0.4.0              gtools_3.9.4               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.16.0          limma_3.56.2               
##  [9] eulerr_7.0.0                mitch_1.12.0               
## [11] MASS_7.3-60                 fgsea_1.26.0               
## [13] gplots_3.1.3                DESeq2_1.40.2              
## [15] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [17] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [19] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [21] IRanges_2.34.1              S4Vectors_0.38.1           
## [23] BiocGenerics_0.46.0         reshape2_1.4.4             
## [25] lubridate_1.9.2             forcats_1.0.0              
## [27] stringr_1.5.0               dplyr_1.1.2                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.3               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.2             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          systemfonts_1.0.4      
##  [7] vctrs_0.6.3             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.40.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.3             
## [16] promises_1.2.1          rmarkdown_2.24          tzdb_0.4.0             
## [19] xfun_0.40               zlibbioc_1.46.0         cachem_1.0.8           
## [22] jsonlite_1.8.7          highr_0.10              later_1.3.1            
## [25] DelayedArray_0.26.7     reshape_0.8.9           BiocParallel_1.34.2    
## [28] parallel_4.3.1          R6_2.5.1                bslib_0.5.1            
## [31] stringi_1.7.12          RColorBrewer_1.1-3      jquerylib_0.1.4        
## [34] assertthat_0.2.1        Rcpp_1.0.11             knitr_1.43             
## [37] httpuv_1.6.11           Matrix_1.6-1            timechange_0.2.0       
## [40] tidyselect_1.2.0        rstudioapi_0.15.0       abind_1.4-5            
## [43] yaml_2.3.7              codetools_0.2-19        lattice_0.21-8         
## [46] plyr_1.8.8              shiny_1.7.5             withr_2.5.0            
## [49] evaluate_0.21           xml2_1.3.5              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [61] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [70] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [73] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [76] digest_0.6.33           htmlwidgets_1.6.2       htmltools_0.5.6        
## [79] lifecycle_1.0.3         httr_1.4.7              mime_0.12

END of report