date generated: 2024-11-08

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.5190657
7SK 1.0663083
A1BG 2.2404179
A1BG.AS1 0.3021971
A2M 1.4327286
A2M.AS1 0.6108288

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 18383
duplicated_genes_present 0
num_profile_genes_in_sets 8752
num_profile_genes_not_in_sets 9631

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1116
num_genesets_included 1496

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Unwinding of DNA 12 1.11e-05 -0.732 8.19e-05
Heme biosynthesis 13 5.94e-06 -0.725 4.80e-05
Polo-like kinase mediated events 16 6.09e-07 -0.720 6.65e-06
Activation of the pre-replicative complex 32 2.20e-12 -0.717 6.08e-11
Establishment of Sister Chromatid Cohesion 11 4.12e-05 -0.714 2.62e-04
G0 and Early G1 27 3.16e-10 -0.699 6.23e-09
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.71e-05 -0.694 4.08e-04
Crosslinking of collagen fibrils 17 9.90e-07 0.685 1.00e-05
Transcription of E2F targets under negative control by DREAM complex 19 2.60e-07 -0.682 3.19e-06
Collagen biosynthesis and modifying enzymes 63 7.96e-21 0.681 7.44e-19
Mitotic Telophase/Cytokinesis 13 2.30e-05 -0.678 1.53e-04
Diseases associated with glycosaminoglycan metabolism 36 4.15e-12 0.667 1.09e-10
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 4.51e-06 -0.662 3.72e-05
G1/S-Specific Transcription 29 1.05e-09 -0.654 1.88e-08
Condensation of Prometaphase Chromosomes 11 1.72e-04 -0.654 9.48e-04
DNA strand elongation 32 2.12e-10 -0.649 4.49e-09
MET activates PTK2 signaling 29 1.71e-09 0.646 2.90e-08
Condensation of Prophase Chromosomes 24 5.34e-08 -0.641 7.38e-07
Activation of ATR in response to replication stress 37 1.87e-11 -0.638 4.50e-10
CS/DS degradation 11 2.56e-04 0.637 1.35e-03
Collagen formation 83 1.31e-23 0.635 2.17e-21
Scavenging by Class A Receptors 16 1.25e-05 0.631 9.01e-05
Collagen chain trimerization 40 6.42e-12 0.627 1.66e-10
Assembly of collagen fibrils and other multimeric structures 55 8.20e-16 0.627 3.83e-14
Deposition of new CENPA-containing nucleosomes at the centromere 37 4.83e-11 -0.624 1.09e-09
Nucleosome assembly 37 4.83e-11 -0.624 1.09e-09
Cohesin Loading onto Chromatin 10 6.42e-04 -0.623 3.03e-03
Elastic fibre formation 40 1.37e-11 0.618 3.41e-10
A tetrasaccharide linker sequence is required for GAG synthesis 22 6.72e-07 0.612 7.12e-06
Defective B4GALT7 causes EDS, progeroid type 16 2.35e-05 0.611 1.55e-04
ECM proteoglycans 66 9.28e-18 0.610 5.79e-16
Impaired BRCA2 binding to PALB2 24 2.62e-07 -0.607 3.19e-06
Molecules associated with elastic fibres 33 2.02e-09 0.603 3.29e-08
Defective B3GALT6 causes EDSP2 and SEMDJL1 16 3.48e-05 0.598 2.25e-04
HDR through MMEJ (alt-NHEJ) 12 3.39e-04 -0.597 1.72e-03
Lagging Strand Synthesis 20 3.73e-06 -0.597 3.19e-05
Defective B3GAT3 causes JDSSDHD 16 3.81e-05 0.595 2.44e-04
Anchoring fibril formation 13 2.27e-04 0.590 1.22e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.35e-04 -0.589 7.70e-04
FGFR2 ligand binding and activation 10 1.43e-03 0.582 6.05e-03
Processive synthesis on the lagging strand 15 9.61e-05 -0.582 5.59e-04
Meiotic recombination 33 7.37e-09 -0.581 1.12e-07
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 3.35e-04 0.575 1.70e-03
Defective EXT2 causes exostoses 2 13 3.35e-04 0.575 1.70e-03
Signaling by Erythropoietin 24 1.49e-06 -0.567 1.41e-05
Mismatch Repair 15 1.53e-04 -0.565 8.56e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.30e-06 -0.559 1.26e-05
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.30e-06 -0.559 1.26e-05
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.30e-06 -0.559 1.26e-05
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.30e-06 -0.559 1.26e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Unwinding of DNA 12 1.11e-05 -7.32e-01 8.19e-05
Heme biosynthesis 13 5.94e-06 -7.25e-01 4.80e-05
Polo-like kinase mediated events 16 6.09e-07 -7.20e-01 6.65e-06
Activation of the pre-replicative complex 32 2.20e-12 -7.17e-01 6.08e-11
Establishment of Sister Chromatid Cohesion 11 4.12e-05 -7.14e-01 2.62e-04
G0 and Early G1 27 3.16e-10 -6.99e-01 6.23e-09
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.71e-05 -6.94e-01 4.08e-04
Crosslinking of collagen fibrils 17 9.90e-07 6.85e-01 1.00e-05
Transcription of E2F targets under negative control by DREAM complex 19 2.60e-07 -6.82e-01 3.19e-06
Collagen biosynthesis and modifying enzymes 63 7.96e-21 6.81e-01 7.44e-19
Mitotic Telophase/Cytokinesis 13 2.30e-05 -6.78e-01 1.53e-04
Diseases associated with glycosaminoglycan metabolism 36 4.15e-12 6.67e-01 1.09e-10
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 4.51e-06 -6.62e-01 3.72e-05
G1/S-Specific Transcription 29 1.05e-09 -6.54e-01 1.88e-08
Condensation of Prometaphase Chromosomes 11 1.72e-04 -6.54e-01 9.48e-04
DNA strand elongation 32 2.12e-10 -6.49e-01 4.49e-09
MET activates PTK2 signaling 29 1.71e-09 6.46e-01 2.90e-08
Condensation of Prophase Chromosomes 24 5.34e-08 -6.41e-01 7.38e-07
Activation of ATR in response to replication stress 37 1.87e-11 -6.38e-01 4.50e-10
CS/DS degradation 11 2.56e-04 6.37e-01 1.35e-03
Collagen formation 83 1.31e-23 6.35e-01 2.17e-21
Scavenging by Class A Receptors 16 1.25e-05 6.31e-01 9.01e-05
Collagen chain trimerization 40 6.42e-12 6.27e-01 1.66e-10
Assembly of collagen fibrils and other multimeric structures 55 8.20e-16 6.27e-01 3.83e-14
Deposition of new CENPA-containing nucleosomes at the centromere 37 4.83e-11 -6.24e-01 1.09e-09
Nucleosome assembly 37 4.83e-11 -6.24e-01 1.09e-09
Cohesin Loading onto Chromatin 10 6.42e-04 -6.23e-01 3.03e-03
Elastic fibre formation 40 1.37e-11 6.18e-01 3.41e-10
A tetrasaccharide linker sequence is required for GAG synthesis 22 6.72e-07 6.12e-01 7.12e-06
Defective B4GALT7 causes EDS, progeroid type 16 2.35e-05 6.11e-01 1.55e-04
ECM proteoglycans 66 9.28e-18 6.10e-01 5.79e-16
Impaired BRCA2 binding to PALB2 24 2.62e-07 -6.07e-01 3.19e-06
Molecules associated with elastic fibres 33 2.02e-09 6.03e-01 3.29e-08
Defective B3GALT6 causes EDSP2 and SEMDJL1 16 3.48e-05 5.98e-01 2.25e-04
HDR through MMEJ (alt-NHEJ) 12 3.39e-04 -5.97e-01 1.72e-03
Lagging Strand Synthesis 20 3.73e-06 -5.97e-01 3.19e-05
Defective B3GAT3 causes JDSSDHD 16 3.81e-05 5.95e-01 2.44e-04
Anchoring fibril formation 13 2.27e-04 5.90e-01 1.22e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.35e-04 -5.89e-01 7.70e-04
FGFR2 ligand binding and activation 10 1.43e-03 5.82e-01 6.05e-03
Processive synthesis on the lagging strand 15 9.61e-05 -5.82e-01 5.59e-04
Meiotic recombination 33 7.37e-09 -5.81e-01 1.12e-07
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 3.35e-04 5.75e-01 1.70e-03
Defective EXT2 causes exostoses 2 13 3.35e-04 5.75e-01 1.70e-03
Signaling by Erythropoietin 24 1.49e-06 -5.67e-01 1.41e-05
Mismatch Repair 15 1.53e-04 -5.65e-01 8.56e-04
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 25 1.30e-06 -5.59e-01 1.26e-05
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 25 1.30e-06 -5.59e-01 1.26e-05
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 25 1.30e-06 -5.59e-01 1.26e-05
Defective homologous recombination repair (HRR) due to PALB2 loss of function 25 1.30e-06 -5.59e-01 1.26e-05
E2F mediated regulation of DNA replication 22 6.09e-06 -5.57e-01 4.90e-05
Removal of the Flap Intermediate 14 3.12e-04 -5.56e-01 1.62e-03
Non-integrin membrane-ECM interactions 55 1.04e-12 5.55e-01 2.94e-11
Resolution of D-loop Structures through Holliday Junction Intermediates 33 3.38e-08 -5.55e-01 4.82e-07
Presynaptic phase of homologous DNA pairing and strand exchange 40 1.89e-09 -5.49e-01 3.10e-08
Impaired BRCA2 binding to RAD51 35 1.98e-08 -5.48e-01 2.88e-07
Homologous DNA Pairing and Strand Exchange 43 5.29e-10 -5.47e-01 1.01e-08
PCNA-Dependent Long Patch Base Excision Repair 21 1.46e-05 -5.46e-01 1.04e-04
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 4.27e-04 -5.44e-01 2.11e-03
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 41 1.82e-09 -5.43e-01 3.02e-08
Diseases of DNA Double-Strand Break Repair 41 1.82e-09 -5.43e-01 3.02e-08
NCAM1 interactions 33 7.05e-08 5.42e-01 9.58e-07
Resolution of D-Loop Structures 34 5.38e-08 -5.39e-01 7.38e-07
Erythropoietin activates RAS 13 8.14e-04 -5.36e-01 3.69e-03
Phase 4 - resting membrane potential 10 3.39e-03 5.35e-01 1.26e-02
Presynaptic depolarization and calcium channel opening 10 3.45e-03 5.34e-01 1.27e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 27 1.56e-06 -5.34e-01 1.45e-05
Pentose phosphate pathway 13 8.81e-04 -5.33e-01 3.95e-03
Keratan sulfate degradation 12 1.56e-03 5.27e-01 6.53e-03
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 1.56e-03 -5.27e-01 6.54e-03
Syndecan interactions 26 3.26e-06 5.27e-01 2.82e-05
Assembly of the ORC complex at the origin of replication 20 4.66e-05 -5.26e-01 2.94e-04
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.74e-04 -5.26e-01 9.56e-04
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.74e-04 -5.26e-01 9.56e-04
Collagen degradation 55 1.54e-11 5.26e-01 3.78e-10
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 92 4.20e-18 -5.23e-01 2.99e-16
Amplification of signal from the kinetochores 92 4.20e-18 -5.23e-01 2.99e-16
Chondroitin sulfate/dermatan sulfate metabolism 45 1.48e-09 5.21e-01 2.57e-08
Defective pyroptosis 24 1.00e-05 -5.21e-01 7.44e-05
RNA Polymerase I Promoter Opening 14 7.66e-04 -5.19e-01 3.54e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 2.41e-04 -5.14e-01 1.29e-03
PRC2 methylates histones and DNA 24 1.42e-05 -5.12e-01 1.02e-04
SUMOylation of DNA replication proteins 46 2.61e-09 -5.07e-01 4.21e-08
Telomere C-strand (Lagging Strand) Synthesis 34 3.15e-07 -5.07e-01 3.75e-06
Nuclear Pore Complex (NPC) Disassembly 36 1.50e-07 -5.06e-01 1.91e-06
Metabolism of porphyrins 21 6.16e-05 -5.05e-01 3.78e-04
Processive synthesis on the C-strand of the telomere 19 1.39e-04 -5.05e-01 7.84e-04
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 1.63e-03 -5.05e-01 6.77e-03
Diseases of DNA repair 51 7.26e-10 -4.99e-01 1.36e-08
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.62e-05 -4.98e-01 1.13e-04
DNA Damage/Telomere Stress Induced Senescence 39 7.85e-08 -4.97e-01 1.04e-06
Leading Strand Synthesis 14 1.29e-03 -4.97e-01 5.60e-03
Polymerase switching 14 1.29e-03 -4.97e-01 5.60e-03
Early Phase of HIV Life Cycle 14 1.31e-03 -4.96e-01 5.64e-03
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.46e-06 -4.92e-01 1.39e-05
Transcriptional Regulation by E2F6 34 8.03e-07 -4.89e-01 8.22e-06
Resolution of Sister Chromatid Cohesion 116 1.38e-19 -4.86e-01 1.15e-17
Rev-mediated nuclear export of HIV RNA 35 6.60e-07 -4.86e-01 7.05e-06
Mitotic Spindle Checkpoint 109 1.93e-18 -4.85e-01 1.52e-16
CD22 mediated BCR regulation 12 3.67e-03 -4.84e-01 1.33e-02
Striated Muscle Contraction 33 1.54e-06 4.83e-01 1.44e-05
DNA methylation 15 1.20e-03 -4.83e-01 5.23e-03
Laminin interactions 28 1.00e-05 4.82e-01 7.44e-05
HDR through Single Strand Annealing (SSA) 37 4.65e-07 -4.79e-01 5.31e-06
Meiosis 59 2.13e-10 -4.78e-01 4.49e-09
Transcriptional regulation of granulopoiesis 41 1.30e-07 -4.76e-01 1.69e-06
STAT5 activation downstream of FLT3 ITD mutants 10 9.30e-03 -4.75e-01 2.96e-02
Removal of the Flap Intermediate from the C-strand 17 6.98e-04 -4.75e-01 3.24e-03
IRAK4 deficiency (TLR2/4) 15 1.46e-03 -4.75e-01 6.15e-03
EML4 and NUDC in mitotic spindle formation 107 2.15e-17 -4.75e-01 1.24e-15
Termination of translesion DNA synthesis 31 5.37e-06 -4.72e-01 4.37e-05
Interactions of Rev with host cellular proteins 37 6.85e-07 -4.72e-01 7.17e-06
Transport of Ribonucleoproteins into the Host Nucleus 32 4.07e-06 -4.71e-01 3.40e-05
Vpr-mediated nuclear import of PICs 34 2.05e-06 -4.71e-01 1.80e-05
HDR through Homologous Recombination (HRR) 67 2.88e-11 -4.70e-01 6.84e-10
MyD88 deficiency (TLR2/4) 14 2.43e-03 -4.68e-01 9.51e-03
HDMs demethylate histones 21 2.13e-04 -4.67e-01 1.16e-03
Regulation of FOXO transcriptional activity by acetylation 10 1.07e-02 -4.66e-01 3.31e-02
Export of Viral Ribonucleoproteins from Nucleus 33 3.56e-06 -4.66e-01 3.06e-05
Processing of Intronless Pre-mRNAs 20 3.56e-04 -4.61e-01 1.79e-03
Regulation of IFNG signaling 13 4.17e-03 -4.59e-01 1.49e-02
O-glycosylation of TSR domain-containing proteins 36 1.95e-06 4.58e-01 1.73e-05
Nuclear import of Rev protein 34 3.82e-06 -4.58e-01 3.23e-05
NS1 Mediated Effects on Host Pathways 40 5.69e-07 -4.57e-01 6.26e-06
Post-translational protein phosphorylation 83 7.01e-13 4.56e-01 2.06e-11
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 95 1.79e-14 4.55e-01 7.03e-13
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 1.21e-05 -4.54e-01 8.80e-05
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 1.21e-05 -4.54e-01 8.80e-05
Packaging Of Telomere Ends 17 1.20e-03 -4.54e-01 5.23e-03
G2/M DNA damage checkpoint 63 5.90e-10 -4.51e-01 1.12e-08
Postmitotic nuclear pore complex (NPC) reformation 27 5.37e-05 -4.49e-01 3.33e-04
Defective B3GALTL causes PpS 35 4.45e-06 4.48e-01 3.70e-05
TP53 Regulates Transcription of Caspase Activators and Caspases 12 7.42e-03 -4.46e-01 2.48e-02
Recognition of DNA damage by PCNA-containing replication complex 30 2.51e-05 -4.44e-01 1.65e-04
Interleukin-15 signaling 14 4.06e-03 -4.43e-01 1.45e-02
SUMOylation of ubiquitinylation proteins 39 1.71e-06 -4.43e-01 1.52e-05
DNA Damage Bypass 46 2.60e-07 -4.39e-01 3.19e-06
SIRT1 negatively regulates rRNA expression 19 9.36e-04 -4.38e-01 4.16e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 17 1.83e-03 -4.37e-01 7.51e-03
Translesion synthesis by POLI 17 1.85e-03 -4.36e-01 7.59e-03
Processing and activation of SUMO 10 1.73e-02 -4.35e-01 4.88e-02
SUMOylation of SUMOylation proteins 35 8.64e-06 -4.34e-01 6.63e-05
Extension of Telomeres 50 1.31e-07 -4.31e-01 1.69e-06
Processing of DNA double-strand break ends 67 1.04e-09 -4.31e-01 1.87e-08
Chromosome Maintenance 100 9.80e-14 -4.31e-01 3.49e-12
Translesion Synthesis by POLH 18 1.59e-03 -4.30e-01 6.61e-03
Signaling by FLT3 ITD and TKD mutants 16 2.93e-03 -4.30e-01 1.11e-02
Transport of the SLBP Dependant Mature mRNA 36 8.34e-06 -4.29e-01 6.47e-05
Mitotic Prometaphase 193 8.93e-25 -4.29e-01 1.67e-22
Extracellular matrix organization 264 4.51e-33 4.28e-01 1.69e-30
Cell Cycle Checkpoints 255 5.22e-32 -4.28e-01 1.56e-29
Nuclear Envelope Breakdown 53 7.46e-08 -4.27e-01 9.96e-07
TP53 Regulates Transcription of Cell Cycle Genes 47 4.10e-07 -4.27e-01 4.72e-06
Metalloprotease DUBs 21 7.31e-04 -4.26e-01 3.39e-03
mRNA 3’-end processing 57 3.30e-08 -4.23e-01 4.75e-07
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.60e-06 -4.23e-01 1.46e-05
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.52e-04 -4.23e-01 1.34e-03
LGI-ADAM interactions 11 1.53e-02 4.22e-01 4.52e-02
Aspartate and asparagine metabolism 10 2.08e-02 4.22e-01 5.70e-02
Interleukin receptor SHC signaling 23 4.69e-04 -4.21e-01 2.29e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 9.27e-06 -4.21e-01 7.08e-05
Processing of Capped Intronless Pre-mRNA 29 8.97e-05 -4.20e-01 5.24e-04
Role of LAT2/NTAL/LAB on calcium mobilization 22 6.57e-04 -4.20e-01 3.09e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.35e-05 -4.19e-01 9.68e-05
MASTL Facilitates Mitotic Progression 10 2.23e-02 -4.17e-01 5.98e-02
Transport of the SLBP independent Mature mRNA 35 2.01e-05 -4.16e-01 1.35e-04
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 1.70e-02 -4.16e-01 4.81e-02
Meiotic synapsis 38 9.50e-06 -4.15e-01 7.21e-05
Homology Directed Repair 107 1.22e-13 -4.15e-01 4.13e-12
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 27 1.92e-04 -4.15e-01 1.05e-03
Polymerase switching on the C-strand of the telomere 26 2.55e-04 -4.14e-01 1.35e-03
Transport of Mature mRNA Derived from an Intronless Transcript 42 3.81e-06 -4.12e-01 3.23e-05
Translesion synthesis by POLK 17 3.31e-03 -4.12e-01 1.24e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.62e-09 -4.11e-01 2.78e-08
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 37 1.52e-05 -4.11e-01 1.07e-04
Phosphorylation of CD3 and TCR zeta chains 13 1.03e-02 -4.11e-01 3.23e-02
Diseases associated with the TLR signaling cascade 28 1.70e-04 -4.11e-01 9.41e-04
Diseases of Immune System 28 1.70e-04 -4.11e-01 9.41e-04
RNA Polymerase II Transcription Termination 66 8.09e-09 -4.10e-01 1.21e-07
Translesion synthesis by REV1 16 4.51e-03 -4.10e-01 1.59e-02
Transport of Mature Transcript to Cytoplasm 81 1.86e-10 -4.10e-01 4.03e-09
Chondroitin sulfate biosynthesis 16 4.59e-03 4.09e-01 1.62e-02
MET promotes cell motility 39 1.00e-05 4.09e-01 7.44e-05
DNA Replication 136 2.21e-16 -4.08e-01 1.10e-14
DNA Double-Strand Break Repair 137 1.82e-16 -4.07e-01 9.41e-15
Mitotic G1 phase and G1/S transition 148 1.27e-17 -4.07e-01 7.59e-16
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 5.06e-03 -4.05e-01 1.76e-02
Nonhomologous End-Joining (NHEJ) 38 1.62e-05 -4.04e-01 1.13e-04
G1/S Transition 130 1.88e-15 -4.04e-01 8.29e-14
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 101 2.50e-12 -4.03e-01 6.81e-11
Nucleotide biosynthesis 12 1.60e-02 -4.02e-01 4.61e-02
Maturation of nucleoprotein 9683610 11 2.15e-02 -4.00e-01 5.80e-02
Cyclin A/B1/B2 associated events during G2/M transition 25 5.36e-04 -4.00e-01 2.56e-03
CRMPs in Sema3A signaling 15 7.35e-03 4.00e-01 2.47e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 47 2.15e-06 -4.00e-01 1.88e-05
Phase 0 - rapid depolarisation 26 4.23e-04 3.99e-01 2.09e-03
Erythrocytes take up carbon dioxide and release oxygen 12 1.66e-02 -3.99e-01 4.72e-02
O2/CO2 exchange in erythrocytes 12 1.66e-02 -3.99e-01 4.72e-02
Interactions of Vpr with host cellular proteins 37 2.63e-05 -3.99e-01 1.72e-04
G2/M Checkpoints 134 1.80e-15 -3.98e-01 8.16e-14
Regulation of TP53 Activity through Phosphorylation 89 1.03e-10 -3.96e-01 2.28e-09
ERBB2 Activates PTK6 Signaling 12 1.75e-02 3.96e-01 4.90e-02
Long-term potentiation 23 1.03e-03 3.95e-01 4.54e-03
Diseases of mitotic cell cycle 38 2.59e-05 -3.94e-01 1.70e-04
HS-GAG degradation 20 2.27e-03 3.94e-01 9.04e-03
PKMTs methylate histone lysines 42 1.00e-05 -3.94e-01 7.44e-05
S Phase 161 6.55e-18 -3.94e-01 4.26e-16
Cell Cycle, Mitotic 498 4.85e-51 -3.93e-01 3.63e-48
Interferon alpha/beta signaling 57 2.93e-07 -3.93e-01 3.54e-06
Interleukin-3, Interleukin-5 and GM-CSF signaling 44 6.73e-06 -3.92e-01 5.33e-05
MAPK3 (ERK1) activation 10 3.19e-02 -3.92e-01 7.87e-02
Signaling by cytosolic FGFR1 fusion mutants 18 4.03e-03 -3.91e-01 1.45e-02
Growth hormone receptor signaling 20 2.51e-03 -3.90e-01 9.71e-03
Unblocking of NMDA receptors, glutamate binding and activation 21 1.98e-03 3.90e-01 8.07e-03
SUMOylation of DNA damage response and repair proteins 77 3.43e-09 -3.89e-01 5.35e-08
Cleavage of the damaged purine 21 2.08e-03 -3.88e-01 8.34e-03
Depurination 21 2.08e-03 -3.88e-01 8.34e-03
Recognition and association of DNA glycosylase with site containing an affected purine 21 2.08e-03 -3.88e-01 8.34e-03
Initiation of Nuclear Envelope (NE) Reformation 19 3.45e-03 -3.88e-01 1.27e-02
Regulation of IFNA/IFNB signaling 12 2.02e-02 -3.87e-01 5.53e-02
Diseases of glycosylation 126 6.94e-14 3.86e-01 2.53e-12
DNA Replication Pre-Initiation 110 3.80e-12 -3.83e-01 1.01e-10
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.30e-02 -3.83e-01 3.98e-02
Heparan sulfate/heparin (HS-GAG) metabolism 43 1.44e-05 3.82e-01 1.03e-04
Interleukin-2 family signaling 37 5.80e-05 -3.82e-01 3.57e-04
The activation of arylsulfatases 10 3.67e-02 3.82e-01 8.78e-02
Base Excision Repair 56 7.98e-07 -3.81e-01 8.22e-06
Prolactin receptor signaling 11 2.87e-02 -3.81e-01 7.15e-02
Cell Cycle 614 2.02e-58 -3.81e-01 3.03e-55
Synthesis of DNA 119 8.99e-13 -3.79e-01 2.59e-11
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.67e-03 -3.79e-01 1.02e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.67e-03 -3.79e-01 1.02e-02
SUMOylation of RNA binding proteins 47 7.63e-06 -3.77e-01 5.94e-05
RIP-mediated NFkB activation via ZBP1 17 7.17e-03 -3.77e-01 2.41e-02
Mitotic Prophase 93 3.62e-10 -3.76e-01 7.02e-09
Keratan sulfate biosynthesis 26 9.04e-04 3.76e-01 4.03e-03
Separation of Sister Chromatids 179 4.50e-18 -3.75e-01 3.06e-16
Diseases associated with O-glycosylation of proteins 56 1.19e-06 3.75e-01 1.19e-05
Dissolution of Fibrin Clot 12 2.46e-02 3.75e-01 6.37e-02
Attachment and Entry 9694614 15 1.22e-02 3.74e-01 3.75e-02
Synthesis of PIPs at the late endosome membrane 11 3.25e-02 -3.72e-01 8.00e-02
APC truncation mutants have impaired AXIN binding 14 1.59e-02 -3.72e-01 4.59e-02
AXIN missense mutants destabilize the destruction complex 14 1.59e-02 -3.72e-01 4.59e-02
Signaling by AMER1 mutants 14 1.59e-02 -3.72e-01 4.59e-02
Signaling by APC mutants 14 1.59e-02 -3.72e-01 4.59e-02
Signaling by AXIN mutants 14 1.59e-02 -3.72e-01 4.59e-02
Truncations of AMER1 destabilize the destruction complex 14 1.59e-02 -3.72e-01 4.59e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.57e-02 -3.72e-01 6.60e-02
Mitotic Metaphase and Anaphase 224 1.34e-21 -3.70e-01 1.54e-19
eNOS activation 11 3.36e-02 3.70e-01 8.16e-02
Reproduction 78 1.77e-08 -3.69e-01 2.60e-07
RUNX2 regulates bone development 30 4.72e-04 3.69e-01 2.29e-03
Phosphorylation of the APC/C 20 4.30e-03 -3.69e-01 1.53e-02
Mitotic Anaphase 223 3.10e-21 -3.68e-01 3.27e-19
Interleukin-7 signaling 21 3.56e-03 -3.67e-01 1.30e-02
Fanconi Anemia Pathway 36 1.37e-04 -3.67e-01 7.78e-04
SUMOylation of chromatin organization proteins 57 1.67e-06 -3.67e-01 1.49e-05
Degradation of the extracellular matrix 116 9.13e-12 3.67e-01 2.32e-10
Transcriptional regulation by small RNAs 58 1.43e-06 -3.66e-01 1.37e-05
RHO GTPases Activate Formins 130 5.88e-13 -3.66e-01 1.76e-11
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 9.08e-03 -3.66e-01 2.91e-02
Mucopolysaccharidoses 11 3.61e-02 3.65e-01 8.67e-02
Signaling by PDGFR in disease 20 4.76e-03 -3.65e-01 1.67e-02
M Phase 355 1.65e-31 -3.61e-01 4.12e-29
Synthesis of glycosylphosphatidylinositol (GPI) 18 8.32e-03 -3.59e-01 2.73e-02
Receptor-type tyrosine-protein phosphatases 15 1.61e-02 3.59e-01 4.62e-02
ALK mutants bind TKIs 11 3.93e-02 -3.59e-01 9.28e-02
Metabolism of non-coding RNA 53 6.59e-06 -3.58e-01 5.24e-05
snRNP Assembly 53 6.59e-06 -3.58e-01 5.24e-05
RUNX2 regulates osteoblast differentiation 23 3.07e-03 3.57e-01 1.16e-02
Interleukin-2 signaling 11 4.08e-02 -3.56e-01 9.62e-02
Signaling by PDGFRA extracellular domain mutants 12 3.34e-02 -3.55e-01 8.14e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.34e-02 -3.55e-01 8.14e-02
Glycosaminoglycan metabolism 109 2.55e-10 3.51e-01 5.22e-09
Antiviral mechanism by IFN-stimulated genes 79 7.43e-08 -3.50e-01 9.96e-07
Telomere Maintenance 75 1.75e-07 -3.49e-01 2.21e-06
AURKA Activation by TPX2 71 4.96e-07 -3.45e-01 5.62e-06
Processing of Capped Intron-Containing Pre-mRNA 279 4.09e-23 -3.44e-01 5.10e-21
Beta-catenin phosphorylation cascade 17 1.41e-02 -3.44e-01 4.24e-02
Ion homeostasis 48 3.85e-05 3.43e-01 2.46e-04
Cleavage of the damaged pyrimidine 26 2.45e-03 -3.43e-01 9.51e-03
Depyrimidination 26 2.45e-03 -3.43e-01 9.51e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 26 2.45e-03 -3.43e-01 9.51e-03
Regulation of TP53 Activity 154 2.06e-13 -3.43e-01 6.42e-12
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 7.95e-03 -3.43e-01 2.62e-02
SUMOylation 167 2.39e-14 -3.42e-01 9.18e-13
Oxidative Stress Induced Senescence 74 3.65e-07 -3.42e-01 4.26e-06
Transport of vitamins, nucleosides, and related molecules 32 8.99e-04 3.39e-01 4.01e-03
Rap1 signalling 15 2.32e-02 -3.39e-01 6.16e-02
RORA activates gene expression 18 1.32e-02 -3.38e-01 3.99e-02
Lysosphingolipid and LPA receptors 12 4.29e-02 3.38e-01 1.00e-01
SUMO E3 ligases SUMOylate target proteins 161 1.69e-13 -3.37e-01 5.63e-12
Signaling by FGFR4 in disease 10 6.57e-02 -3.36e-01 1.40e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 4.43e-02 -3.35e-01 1.02e-01
alpha-linolenic acid (ALA) metabolism 12 4.43e-02 -3.35e-01 1.02e-01
Resolution of Abasic Sites (AP sites) 38 3.49e-04 -3.35e-01 1.77e-03
Deadenylation of mRNA 22 6.74e-03 -3.34e-01 2.29e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.84e-03 -3.33e-01 3.10e-02
Regulation of signaling by CBL 22 6.92e-03 -3.33e-01 2.34e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 8.05e-09 -3.32e-01 1.21e-07
ISG15 antiviral mechanism 71 1.37e-06 -3.31e-01 1.32e-05
FOXO-mediated transcription of cell death genes 16 2.17e-02 -3.31e-01 5.85e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 11 5.71e-02 3.31e-01 1.26e-01
FLT3 Signaling 38 4.13e-04 -3.31e-01 2.06e-03
Activation of Matrix Metalloproteinases 26 3.48e-03 3.31e-01 1.28e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 3.26e-02 3.30e-01 8.00e-02
FCERI mediated MAPK activation 38 4.46e-04 -3.29e-01 2.20e-03
Acyl chain remodelling of PI 12 4.85e-02 3.29e-01 1.09e-01
MET activates RAP1 and RAC1 11 5.89e-02 -3.29e-01 1.29e-01
Regulation of CDH11 function 10 7.19e-02 3.29e-01 1.50e-01
Regulation of TP53 Activity through Acetylation 29 2.21e-03 -3.28e-01 8.83e-03
mRNA decay by 5’ to 3’ exoribonuclease 15 2.77e-02 -3.28e-01 6.97e-02
Assembly of the pre-replicative complex 94 3.82e-08 -3.28e-01 5.40e-07
Telomere C-strand synthesis initiation 13 4.10e-02 -3.27e-01 9.66e-02
STAT3 nuclear events downstream of ALK signaling 10 7.37e-02 -3.27e-01 1.53e-01
Keratan sulfate/keratin metabolism 32 1.40e-03 3.26e-01 5.95e-03
Signaling by CSF3 (G-CSF) 29 2.43e-03 -3.25e-01 9.51e-03
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 12 5.11e-02 3.25e-01 1.14e-01
DCC mediated attractive signaling 13 4.33e-02 3.24e-01 1.01e-01
Formation of WDR5-containing histone-modifying complexes 42 2.91e-04 -3.23e-01 1.52e-03
mRNA Splicing - Major Pathway 203 3.63e-15 -3.20e-01 1.55e-13
Loss of Nlp from mitotic centrosomes 68 5.00e-06 -3.20e-01 4.08e-05
Loss of proteins required for interphase microtubule organization from the centrosome 68 5.00e-06 -3.20e-01 4.08e-05
APC-Cdc20 mediated degradation of Nek2A 26 4.85e-03 -3.19e-01 1.70e-02
Synthesis of PIPs at the early endosome membrane 16 2.72e-02 -3.19e-01 6.88e-02
Zinc transporters 11 6.71e-02 3.19e-01 1.42e-01
Interleukin-20 family signaling 14 3.92e-02 -3.18e-01 9.28e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.65e-02 -3.18e-01 1.25e-01
Translocation of ZAP-70 to Immunological synapse 10 8.19e-02 -3.18e-01 1.65e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 13 4.74e-02 -3.18e-01 1.07e-01
Platelet sensitization by LDL 17 2.38e-02 -3.17e-01 6.24e-02
Switching of origins to a post-replicative state 90 2.27e-07 -3.16e-01 2.83e-06
HCMV Early Events 82 9.24e-07 -3.13e-01 9.40e-06
Cellular Senescence 138 2.66e-10 -3.12e-01 5.37e-09
Interleukin-6 signaling 11 7.39e-02 -3.11e-01 1.53e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 7.39e-02 -3.11e-01 1.53e-01
mRNA Splicing 211 7.40e-15 -3.11e-01 3.08e-13
APC/C-mediated degradation of cell cycle proteins 86 6.48e-07 -3.10e-01 6.97e-06
Regulation of mitotic cell cycle 86 6.48e-07 -3.10e-01 6.97e-06
CASP8 activity is inhibited 11 7.49e-02 -3.10e-01 1.54e-01
Dimerization of procaspase-8 11 7.49e-02 -3.10e-01 1.54e-01
Regulation by c-FLIP 11 7.49e-02 -3.10e-01 1.54e-01
DNA Repair 291 1.08e-19 -3.09e-01 9.53e-18
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.76e-02 -3.09e-01 6.96e-02
Regulation of TP53 Expression and Degradation 37 1.20e-03 -3.08e-01 5.24e-03
Viral Messenger RNA Synthesis 44 4.17e-04 -3.07e-01 2.08e-03
Inactivation of CSF3 (G-CSF) signaling 24 9.27e-03 -3.07e-01 2.96e-02
Activation of SMO 17 2.85e-02 3.07e-01 7.12e-02
HATs acetylate histones 90 5.08e-07 -3.06e-01 5.71e-06
Myogenesis 24 9.52e-03 3.06e-01 3.02e-02
HS-GAG biosynthesis 23 1.11e-02 3.06e-01 3.44e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.83e-02 -3.05e-01 5.10e-02
Gene Silencing by RNA 83 1.61e-06 -3.05e-01 1.46e-05
Regulation of TP53 Degradation 36 1.65e-03 -3.03e-01 6.82e-03
CD28 dependent Vav1 pathway 11 8.21e-02 -3.03e-01 1.65e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.91e-02 -3.03e-01 5.29e-02
RHO GTPases Activate NADPH Oxidases 21 1.66e-02 -3.02e-01 4.72e-02
TRAF6 mediated IRF7 activation 15 4.33e-02 -3.01e-01 1.01e-01
Nitric oxide stimulates guanylate cyclase 19 2.31e-02 3.01e-01 6.14e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 20 2.01e-02 3.00e-01 5.53e-02
Regulation of PLK1 Activity at G2/M Transition 86 1.57e-06 -3.00e-01 1.45e-05
tRNA processing in the nucleus 59 7.08e-05 -2.99e-01 4.25e-04
CTNNB1 S33 mutants aren’t phosphorylated 15 4.53e-02 -2.99e-01 1.03e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 4.53e-02 -2.99e-01 1.03e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 4.53e-02 -2.99e-01 1.03e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 4.53e-02 -2.99e-01 1.03e-01
Signaling by CTNNB1 phospho-site mutants 15 4.53e-02 -2.99e-01 1.03e-01
Signaling by GSK3beta mutants 15 4.53e-02 -2.99e-01 1.03e-01
Diseases of programmed cell death 55 1.30e-04 -2.98e-01 7.44e-04
Muscle contraction 165 3.83e-11 2.98e-01 8.96e-10
Orc1 removal from chromatin 69 1.90e-05 -2.98e-01 1.29e-04
Olfactory Signaling Pathway 35 2.44e-03 2.96e-01 9.51e-03
Signaling by CSF1 (M-CSF) in myeloid cells 31 4.35e-03 -2.96e-01 1.54e-02
Synthesis of PIPs at the Golgi membrane 15 4.73e-02 -2.96e-01 1.07e-01
Interferon Signaling 167 4.87e-11 -2.95e-01 1.09e-09
Chromatin modifying enzymes 211 1.98e-13 -2.94e-01 6.32e-12
Chromatin organization 211 1.98e-13 -2.94e-01 6.32e-12
Deadenylation-dependent mRNA decay 50 3.31e-04 -2.93e-01 1.70e-03
Cardiac conduction 100 4.08e-07 2.93e-01 4.72e-06
Signaling by KIT in disease 20 2.33e-02 -2.93e-01 6.16e-02
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.33e-02 -2.93e-01 6.16e-02
Generation of second messenger molecules 24 1.31e-02 -2.93e-01 3.98e-02
Regulation of TP53 Activity through Methylation 19 2.78e-02 -2.92e-01 6.98e-02
NCAM signaling for neurite out-growth 54 2.23e-04 2.90e-01 1.20e-03
Centrosome maturation 80 7.38e-06 -2.90e-01 5.78e-05
Recruitment of mitotic centrosome proteins and complexes 80 7.38e-06 -2.90e-01 5.78e-05
Nuclear Envelope (NE) Reassembly 68 3.65e-05 -2.90e-01 2.35e-04
Base-Excision Repair, AP Site Formation 28 8.07e-03 -2.89e-01 2.66e-02
Cyclin D associated events in G1 47 6.02e-04 -2.89e-01 2.85e-03
G1 Phase 47 6.02e-04 -2.89e-01 2.85e-03
Antimicrobial peptides 31 5.36e-03 -2.89e-01 1.85e-02
Processing of SMDT1 15 5.30e-02 -2.89e-01 1.18e-01
Activation of BAD and translocation to mitochondria 14 6.21e-02 -2.88e-01 1.34e-01
Synaptic adhesion-like molecules 20 2.62e-02 2.87e-01 6.68e-02
GPVI-mediated activation cascade 34 3.77e-03 -2.87e-01 1.36e-02
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.49e-02 -2.87e-01 4.44e-02
Negative regulation of MET activity 20 2.65e-02 -2.87e-01 6.76e-02
PD-1 signaling 14 6.38e-02 -2.86e-01 1.37e-01
RHOH GTPase cycle 34 3.90e-03 -2.86e-01 1.41e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 8.78e-02 -2.85e-01 1.73e-01
Diseases of hemostasis 12 8.78e-02 -2.85e-01 1.73e-01
HSF1-dependent transactivation 32 5.49e-03 2.84e-01 1.89e-02
TRAF3-dependent IRF activation pathway 13 7.72e-02 -2.83e-01 1.58e-01
Regulation of PTEN mRNA translation 12 9.10e-02 -2.82e-01 1.78e-01
HCMV Late Events 67 6.94e-05 -2.81e-01 4.18e-04
Protein-protein interactions at synapses 73 3.31e-05 2.81e-01 2.15e-04
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 7.96e-05 -2.81e-01 4.73e-04
STING mediated induction of host immune responses 15 5.99e-02 -2.81e-01 1.31e-01
Deubiquitination 236 1.21e-13 -2.80e-01 4.13e-12
Pre-NOTCH Transcription and Translation 44 1.30e-03 -2.80e-01 5.60e-03
Neurexins and neuroligins 48 8.09e-04 2.79e-01 3.68e-03
Telomere Extension By Telomerase 22 2.38e-02 -2.78e-01 6.24e-02
Depolymerization of the Nuclear Lamina 15 6.23e-02 -2.78e-01 1.34e-01
Metabolism of steroid hormones 22 2.42e-02 2.78e-01 6.32e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 2.12e-02 2.77e-01 5.76e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes 15 6.33e-02 -2.77e-01 1.36e-01
Ub-specific processing proteases 165 8.45e-10 -2.77e-01 1.54e-08
Signal regulatory protein family interactions 12 9.68e-02 -2.77e-01 1.86e-01
MET activates RAS signaling 11 1.12e-01 -2.77e-01 2.10e-01
Retinoid metabolism and transport 30 9.07e-03 2.75e-01 2.91e-02
Expression and translocation of olfactory receptors 30 9.18e-03 2.75e-01 2.94e-02
Regulation of NF-kappa B signaling 18 4.36e-02 -2.75e-01 1.01e-01
Metabolism of Angiotensinogen to Angiotensins 15 6.58e-02 2.74e-01 1.40e-01
Costimulation by the CD28 family 58 3.02e-04 -2.74e-01 1.57e-03
Maturation of nucleoprotein 9694631 15 6.64e-02 -2.74e-01 1.42e-01
Signaling by FLT3 fusion proteins 19 3.91e-02 -2.73e-01 9.27e-02
RHO GTPase Effectors 258 4.22e-14 -2.73e-01 1.58e-12
Neutrophil degranulation 456 1.94e-23 -2.73e-01 2.90e-21
Scavenging of heme from plasma 15 6.84e-02 -2.72e-01 1.44e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 5.28e-02 -2.71e-01 1.17e-01
Prolonged ERK activation events 14 8.08e-02 -2.69e-01 1.63e-01
Endogenous sterols 20 3.74e-02 2.69e-01 8.91e-02
Integrin cell surface interactions 77 4.63e-05 2.69e-01 2.93e-04
TCR signaling 107 1.62e-06 -2.68e-01 1.46e-05
Interleukin-35 Signalling 11 1.25e-01 -2.67e-01 2.28e-01
Dual Incision in GG-NER 41 3.11e-03 -2.67e-01 1.17e-02
Metabolism of nitric oxide: NOS3 activation and regulation 15 7.40e-02 2.66e-01 1.53e-01
Frs2-mediated activation 12 1.11e-01 -2.66e-01 2.08e-01
RHO GTPases activate PKNs 43 2.58e-03 -2.66e-01 9.91e-03
Interferon gamma signaling 75 7.60e-05 -2.64e-01 4.55e-04
RUNX3 regulates NOTCH signaling 14 8.73e-02 -2.64e-01 1.73e-01
Regulation of APC/C activators between G1/S and early anaphase 79 5.07e-05 -2.64e-01 3.16e-04
Regulation of MECP2 expression and activity 30 1.26e-02 -2.63e-01 3.85e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.31e-01 -2.63e-01 2.36e-01
DAP12 interactions 35 7.07e-03 -2.63e-01 2.38e-02
Class B/2 (Secretin family receptors) 66 2.19e-04 2.63e-01 1.19e-03
Signaling by high-kinase activity BRAF mutants 33 8.96e-03 -2.63e-01 2.90e-02
Recruitment of NuMA to mitotic centrosomes 87 2.30e-05 -2.63e-01 1.53e-04
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 8.80e-05 -2.62e-01 5.16e-04
CD28 co-stimulation 32 1.06e-02 -2.61e-01 3.31e-02
Attenuation phase 22 3.42e-02 2.61e-01 8.27e-02
GABA receptor activation 39 4.84e-03 2.61e-01 1.70e-02
Negative regulators of DDX58/IFIH1 signaling 34 9.03e-03 -2.59e-01 2.91e-02
Estrogen-dependent gene expression 98 9.67e-06 -2.59e-01 7.30e-05
Transcriptional Regulation by TP53 347 1.31e-16 -2.59e-01 7.02e-15
Alpha-protein kinase 1 signaling pathway 11 1.38e-01 -2.58e-01 2.47e-01
Activation of BH3-only proteins 29 1.63e-02 -2.58e-01 4.69e-02
RA biosynthesis pathway 19 5.21e-02 2.57e-01 1.16e-01
Regulation of TLR by endogenous ligand 15 8.50e-02 -2.57e-01 1.69e-01
Complex I biogenesis 51 1.52e-03 2.57e-01 6.41e-03
Synthesis of very long-chain fatty acyl-CoAs 21 4.18e-02 -2.57e-01 9.83e-02
Cyclin E associated events during G1/S transition 83 5.38e-05 -2.56e-01 3.33e-04
Oncogene Induced Senescence 33 1.08e-02 -2.56e-01 3.35e-02
Metabolism of fat-soluble vitamins 33 1.10e-02 2.56e-01 3.40e-02
Signaling by Leptin 11 1.43e-01 -2.55e-01 2.55e-01
Cargo concentration in the ER 31 1.41e-02 2.55e-01 4.24e-02
Cyclin A:Cdk2-associated events at S phase entry 85 5.05e-05 -2.54e-01 3.16e-04
Adenylate cyclase inhibitory pathway 12 1.27e-01 2.54e-01 2.31e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 8.88e-02 -2.54e-01 1.75e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 1.67e-04 -2.53e-01 9.30e-04
RMTs methylate histone arginines 35 9.58e-03 -2.53e-01 3.03e-02
Inwardly rectifying K+ channels 25 2.89e-02 2.52e-01 7.19e-02
Epigenetic regulation of gene expression 138 3.15e-07 -2.52e-01 3.75e-06
DAP12 signaling 27 2.37e-02 -2.52e-01 6.24e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 1.70e-01 2.51e-01 2.92e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 2.57e-04 -2.49e-01 1.35e-03
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 1.74e-01 2.48e-01 2.97e-01
Diseases of metabolism 207 7.48e-10 2.48e-01 1.38e-08
Mitotic G2-G2/M phases 190 3.87e-09 -2.48e-01 5.97e-08
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.03e-02 -2.47e-01 3.21e-02
Glutamate Neurotransmitter Release Cycle 22 4.53e-02 2.47e-01 1.03e-01
SARS-CoV-1 activates/modulates innate immune responses 39 7.79e-03 -2.46e-01 2.58e-02
HCMV Infection 106 1.21e-05 -2.46e-01 8.80e-05
Gluconeogenesis 28 2.43e-02 2.46e-01 6.33e-02
FLT3 signaling in disease 28 2.43e-02 -2.46e-01 6.33e-02
Toll Like Receptor 4 (TLR4) Cascade 137 6.91e-07 -2.46e-01 7.17e-06
Signaling by PDGF 55 1.67e-03 2.45e-01 6.89e-03
Eicosanoid ligand-binding receptors 14 1.13e-01 -2.45e-01 2.10e-01
HIV Life Cycle 146 3.28e-07 -2.45e-01 3.87e-06
Fc epsilon receptor (FCERI) signaling 135 1.15e-06 -2.43e-01 1.15e-05
Tie2 Signaling 17 8.35e-02 -2.43e-01 1.66e-01
TAK1-dependent IKK and NF-kappa-B activation 43 6.09e-03 -2.42e-01 2.09e-02
Interleukin-12 signaling 42 6.91e-03 -2.41e-01 2.34e-02
G2/M Transition 188 1.27e-08 -2.41e-01 1.88e-07
Acyl chain remodelling of PG 13 1.33e-01 2.40e-01 2.40e-01
Signaling by the B Cell Receptor (BCR) 115 8.56e-06 -2.40e-01 6.60e-05
FCERI mediated NF-kB activation 85 1.29e-04 -2.40e-01 7.41e-04
Lewis blood group biosynthesis 12 1.50e-01 2.40e-01 2.64e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.65e-05 -2.40e-01 1.13e-04
Toll Like Receptor 2 (TLR2) Cascade 108 1.65e-05 -2.40e-01 1.13e-04
Toll Like Receptor TLR1:TLR2 Cascade 108 1.65e-05 -2.40e-01 1.13e-04
Toll Like Receptor TLR6:TLR2 Cascade 108 1.65e-05 -2.40e-01 1.13e-04
Ras activation upon Ca2+ influx through NMDA receptor 19 7.06e-02 2.40e-01 1.48e-01
HDACs deacetylate histones 43 6.62e-03 -2.39e-01 2.25e-02
O-linked glycosylation 91 7.96e-05 2.39e-01 4.73e-04
TICAM1,TRAF6-dependent induction of TAK1 complex 11 1.70e-01 -2.39e-01 2.92e-01
Signaling by SCF-KIT 42 7.45e-03 -2.39e-01 2.48e-02
Activation of the AP-1 family of transcription factors 10 1.92e-01 -2.38e-01 3.20e-01
Interleukin-27 signaling 10 1.92e-01 -2.38e-01 3.20e-01
Host Interactions of HIV factors 127 3.96e-06 -2.37e-01 3.33e-05
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 5.21e-04 -2.37e-01 2.51e-03
Sensory perception of sweet, bitter, and umami (glutamate) taste 14 1.26e-01 2.36e-01 2.30e-01
G-protein beta:gamma signalling 28 3.09e-02 -2.36e-01 7.67e-02
Activation of GABAB receptors 32 2.11e-02 2.36e-01 5.74e-02
GABA B receptor activation 32 2.11e-02 2.36e-01 5.74e-02
Signaling by RAF1 mutants 38 1.22e-02 -2.35e-01 3.75e-02
DNA Double Strand Break Response 48 4.96e-03 -2.34e-01 1.73e-02
Beta-oxidation of very long chain fatty acids 10 2.00e-01 -2.34e-01 3.28e-01
Folding of actin by CCT/TriC 10 2.01e-01 -2.33e-01 3.29e-01
Netrin-1 signaling 44 7.43e-03 2.33e-01 2.48e-02
GP1b-IX-V activation signalling 12 1.62e-01 -2.33e-01 2.80e-01
Triglyceride metabolism 24 4.90e-02 -2.32e-01 1.10e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 8.02e-02 -2.32e-01 1.62e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.34e-03 -2.32e-01 5.73e-03
SUMOylation of transcription cofactors 44 7.81e-03 -2.32e-01 2.58e-02
Activation of gene expression by SREBF (SREBP) 42 9.43e-03 -2.32e-01 3.00e-02
MAP2K and MAPK activation 37 1.50e-02 -2.31e-01 4.47e-02
Cytochrome c-mediated apoptotic response 13 1.50e-01 -2.31e-01 2.64e-01
Downstream TCR signaling 86 2.21e-04 -2.30e-01 1.19e-03
Toll-like Receptor Cascades 159 5.39e-07 -2.30e-01 6.02e-06
Signaling by FGFR1 in disease 32 2.46e-02 -2.30e-01 6.37e-02
IL-6-type cytokine receptor ligand interactions 15 1.24e-01 2.29e-01 2.27e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 8.52e-04 -2.29e-01 3.83e-03
Signaling by BMP 24 5.29e-02 2.28e-01 1.17e-01
TRAF6 mediated NF-kB activation 23 5.81e-02 -2.28e-01 1.28e-01
PI Metabolism 78 5.36e-04 -2.27e-01 2.56e-03
Metal ion SLC transporters 19 8.80e-02 2.26e-01 1.73e-01
IRF3-mediated induction of type I IFN 12 1.75e-01 -2.26e-01 2.99e-01
CDK-mediated phosphorylation and removal of Cdc6 71 1.00e-03 -2.26e-01 4.44e-03
Transcriptional regulation by RUNX1 179 2.03e-07 -2.25e-01 2.55e-06
RUNX1 regulates transcription of genes involved in differentiation of HSCs 78 5.85e-04 -2.25e-01 2.79e-03
Pre-NOTCH Processing in Golgi 18 9.96e-02 2.24e-01 1.91e-01
Activation of G protein gated Potassium channels 20 8.28e-02 2.24e-01 1.65e-01
G protein gated Potassium channels 20 8.28e-02 2.24e-01 1.65e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 8.28e-02 2.24e-01 1.65e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 35 2.21e-02 -2.23e-01 5.95e-02
Acyl chain remodelling of PS 17 1.11e-01 2.23e-01 2.09e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 47 8.20e-03 -2.23e-01 2.69e-02
Sema3A PAK dependent Axon repulsion 16 1.23e-01 2.22e-01 2.27e-01
Nuclear events stimulated by ALK signaling in cancer 18 1.04e-01 -2.22e-01 1.97e-01
Binding and Uptake of Ligands by Scavenger Receptors 41 1.42e-02 2.21e-01 4.24e-02
EPH-ephrin mediated repulsion of cells 46 9.88e-03 2.20e-01 3.11e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.28e-01 -2.20e-01 2.33e-01
SARS-CoV-2-host interactions 175 5.64e-07 -2.19e-01 6.24e-06
Inflammasomes 21 8.24e-02 -2.19e-01 1.65e-01
NOTCH2 intracellular domain regulates transcription 11 2.09e-01 -2.19e-01 3.39e-01
Senescence-Associated Secretory Phenotype (SASP) 62 2.93e-03 -2.19e-01 1.11e-02
Triglyceride catabolism 16 1.30e-01 -2.18e-01 2.35e-01
KEAP1-NFE2L2 pathway 102 1.39e-04 -2.18e-01 7.84e-04
Cell-cell junction organization 66 2.18e-03 2.18e-01 8.71e-03
Interleukin-12 family signaling 49 8.33e-03 -2.18e-01 2.73e-02
Interaction between L1 and Ankyrins 27 5.05e-02 2.17e-01 1.13e-01
RHOU GTPase cycle 40 1.77e-02 -2.17e-01 4.95e-02
Interleukin-1 signaling 110 8.67e-05 -2.17e-01 5.12e-04
Sensory processing of sound by outer hair cells of the cochlea 42 1.53e-02 2.16e-01 4.52e-02
ER Quality Control Compartment (ERQC) 21 8.66e-02 -2.16e-01 1.72e-01
Purine salvage 13 1.79e-01 -2.15e-01 3.03e-01
Late Phase of HIV Life Cycle 133 1.82e-05 -2.15e-01 1.24e-04
Paradoxical activation of RAF signaling by kinase inactive BRAF 42 1.58e-02 -2.15e-01 4.59e-02
Signaling by RAS mutants 42 1.58e-02 -2.15e-01 4.59e-02
Signaling by moderate kinase activity BRAF mutants 42 1.58e-02 -2.15e-01 4.59e-02
Signaling downstream of RAS mutants 42 1.58e-02 -2.15e-01 4.59e-02
Pregnenolone biosynthesis 11 2.17e-01 2.15e-01 3.49e-01
Transcriptional regulation of white adipocyte differentiation 84 6.86e-04 -2.14e-01 3.20e-03
activated TAK1 mediates p38 MAPK activation 23 7.63e-02 -2.14e-01 1.56e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 7.64e-02 -2.13e-01 1.56e-01
MET receptor recycling 10 2.42e-01 -2.13e-01 3.78e-01
Downregulation of ERBB2 signaling 28 5.07e-02 2.13e-01 1.13e-01
CD28 dependent PI3K/Akt signaling 21 9.12e-02 -2.13e-01 1.78e-01
FGFR2 mutant receptor activation 24 7.12e-02 2.13e-01 1.49e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 3.52e-02 2.12e-01 8.48e-02
SARS-CoV-2 modulates autophagy 11 2.24e-01 -2.12e-01 3.57e-01
Gap junction degradation 12 2.05e-01 2.11e-01 3.33e-01
rRNA processing in the mitochondrion 10 2.50e-01 -2.10e-01 3.85e-01
Sensory perception of taste 18 1.23e-01 2.10e-01 2.26e-01
FCERI mediated Ca+2 mobilization 37 2.72e-02 -2.10e-01 6.88e-02
Dual incision in TC-NER 65 3.49e-03 -2.10e-01 1.28e-02
mRNA Splicing - Minor Pathway 50 1.04e-02 -2.09e-01 3.25e-02
Sensory Perception 169 2.86e-06 2.09e-01 2.48e-05
N-glycan antennae elongation in the medial/trans-Golgi 20 1.06e-01 -2.09e-01 2.01e-01
Adherens junctions interactions 47 1.35e-02 2.08e-01 4.07e-02
InlB-mediated entry of Listeria monocytogenes into host cell 14 1.77e-01 -2.08e-01 3.01e-01
HIV Infection 224 8.76e-08 -2.08e-01 1.15e-06
Integrin signaling 24 7.84e-02 -2.08e-01 1.60e-01
MyD88 cascade initiated on plasma membrane 95 4.74e-04 -2.08e-01 2.29e-03
Toll Like Receptor 10 (TLR10) Cascade 95 4.74e-04 -2.08e-01 2.29e-03
Toll Like Receptor 5 (TLR5) Cascade 95 4.74e-04 -2.08e-01 2.29e-03
Acetylcholine Neurotransmitter Release Cycle 13 1.96e-01 2.07e-01 3.24e-01
NOD1/2 Signaling Pathway 36 3.17e-02 -2.07e-01 7.85e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 3.17e-04 -2.06e-01 1.64e-03
FGFR1 mutant receptor activation 25 7.44e-02 -2.06e-01 1.54e-01
Toll Like Receptor 9 (TLR9) Cascade 105 2.67e-04 -2.06e-01 1.39e-03
Potassium Channels 60 5.84e-03 2.06e-01 2.01e-02
Synthesis of PE 12 2.18e-01 -2.05e-01 3.51e-01
SLC transporter disorders 72 2.58e-03 -2.05e-01 9.91e-03
Inhibition of DNA recombination at telomere 31 4.80e-02 -2.05e-01 1.08e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 28 6.02e-02 2.05e-01 1.31e-01
Trafficking of AMPA receptors 28 6.02e-02 2.05e-01 1.31e-01
Sensory processing of sound by inner hair cells of the cochlea 55 8.53e-03 2.05e-01 2.78e-02
Toll Like Receptor 3 (TLR3) Cascade 103 3.33e-04 -2.05e-01 1.70e-03
Nuclear events mediated by NFE2L2 77 1.94e-03 -2.04e-01 7.92e-03
Amine ligand-binding receptors 11 2.43e-01 2.03e-01 3.78e-01
IRAK2 mediated activation of TAK1 complex 10 2.65e-01 -2.03e-01 4.04e-01
Ovarian tumor domain proteases 35 3.73e-02 -2.03e-01 8.91e-02
WNT ligand biogenesis and trafficking 20 1.16e-01 2.03e-01 2.15e-01
Chaperone Mediated Autophagy 20 1.16e-01 2.03e-01 2.15e-01
Ephrin signaling 19 1.27e-01 2.02e-01 2.30e-01
SLBP independent Processing of Histone Pre-mRNAs 10 2.68e-01 -2.02e-01 4.06e-01
Cell recruitment (pro-inflammatory response) 25 8.03e-02 -2.02e-01 1.62e-01
Purinergic signaling in leishmaniasis infection 25 8.03e-02 -2.02e-01 1.62e-01
MyD88 dependent cascade initiated on endosome 101 4.57e-04 -2.02e-01 2.24e-03
Synthesis of pyrophosphates in the cytosol 10 2.70e-01 -2.01e-01 4.09e-01
Antigen processing-Cross presentation 93 7.97e-04 -2.01e-01 3.66e-03
Formation of apoptosome 11 2.48e-01 -2.01e-01 3.84e-01
Regulation of the apoptosome activity 11 2.48e-01 -2.01e-01 3.84e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 9.67e-03 -2.00e-01 3.05e-02
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 2.52e-01 -1.99e-01 3.87e-01
Sensory processing of sound 58 8.82e-03 1.99e-01 2.86e-02
TICAM1-dependent activation of IRF3/IRF7 12 2.34e-01 -1.98e-01 3.70e-01
ER-Phagosome pathway 79 2.34e-03 -1.98e-01 9.25e-03
APC/C:Cdc20 mediated degradation of Securin 66 5.49e-03 -1.98e-01 1.89e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 29 6.70e-02 -1.97e-01 1.42e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 6.87e-04 -1.97e-01 3.20e-03
Regulation of KIT signaling 16 1.74e-01 -1.96e-01 2.97e-01
RAF activation 34 4.80e-02 -1.96e-01 1.08e-01
G1/S DNA Damage Checkpoints 65 6.40e-03 -1.96e-01 2.19e-02
Pyrimidine salvage 10 2.85e-01 -1.95e-01 4.24e-01
RIPK1-mediated regulated necrosis 31 6.08e-02 -1.95e-01 1.32e-01
Regulation of necroptotic cell death 31 6.08e-02 -1.95e-01 1.32e-01
Synthesis of PIPs at the plasma membrane 50 1.75e-02 -1.94e-01 4.90e-02
Innate Immune System 920 2.46e-23 -1.94e-01 3.34e-21
COPI-mediated anterograde transport 92 1.33e-03 1.94e-01 5.71e-03
Adrenaline,noradrenaline inhibits insulin secretion 24 1.01e-01 1.94e-01 1.93e-01
cGMP effects 15 1.97e-01 1.92e-01 3.25e-01
Glycolysis 67 6.52e-03 -1.92e-01 2.23e-02
Fatty acyl-CoA biosynthesis 34 5.35e-02 -1.91e-01 1.18e-01
Diseases associated with glycosylation precursor biosynthesis 15 2.01e-01 1.91e-01 3.29e-01
Caspase activation via Death Receptors in the presence of ligand 16 1.88e-01 -1.90e-01 3.17e-01
Association of TriC/CCT with target proteins during biosynthesis 35 5.23e-02 -1.90e-01 1.16e-01
Cell junction organization 90 1.91e-03 1.89e-01 7.80e-03
Interleukin-1 family signaling 139 1.18e-04 -1.89e-01 6.79e-04
RAF-independent MAPK1/3 activation 22 1.26e-01 -1.89e-01 2.29e-01
MyD88-independent TLR4 cascade 107 8.03e-04 -1.88e-01 3.66e-03
TRIF(TICAM1)-mediated TLR4 signaling 107 8.03e-04 -1.88e-01 3.66e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.28e-01 -1.88e-01 2.32e-01
UCH proteinases 87 2.53e-03 -1.87e-01 9.74e-03
Metabolism of RNA 699 3.83e-17 -1.87e-01 2.12e-15
Activation of NF-kappaB in B cells 65 9.20e-03 -1.87e-01 2.94e-02
Gap junction trafficking and regulation 32 6.75e-02 1.87e-01 1.43e-01
Defects in cobalamin (B12) metabolism 13 2.44e-01 1.87e-01 3.80e-01
Tight junction interactions 17 1.84e-01 1.86e-01 3.12e-01
Intrinsic Pathway for Apoptosis 54 1.84e-02 -1.86e-01 5.11e-02
Positive epigenetic regulation of rRNA expression 57 1.57e-02 -1.85e-01 4.59e-02
FOXO-mediated transcription 59 1.41e-02 -1.85e-01 4.24e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 2.49e-01 -1.85e-01 3.84e-01
Nucleotide Excision Repair 110 8.26e-04 -1.85e-01 3.73e-03
Metabolism of nucleotides 85 3.31e-03 -1.84e-01 1.24e-02
Activated NTRK2 signals through FRS2 and FRS3 10 3.13e-01 -1.84e-01 4.52e-01
IRAK1 recruits IKK complex 14 2.34e-01 -1.84e-01 3.70e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 2.34e-01 -1.84e-01 3.70e-01
Factors involved in megakaryocyte development and platelet production 126 3.75e-04 -1.84e-01 1.88e-03
Signaling by BRAF and RAF1 fusions 60 1.40e-02 -1.83e-01 4.23e-02
mRNA decay by 3’ to 5’ exoribonuclease 13 2.53e-01 -1.83e-01 3.87e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.93e-01 1.83e-01 4.30e-01
RAB GEFs exchange GTP for GDP on RABs 88 3.00e-03 -1.83e-01 1.13e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 2.52e-02 -1.83e-01 6.49e-02
p53-Independent DNA Damage Response 50 2.52e-02 -1.83e-01 6.49e-02
p53-Independent G1/S DNA damage checkpoint 50 2.52e-02 -1.83e-01 6.49e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 5.26e-03 -1.83e-01 1.83e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 2.20e-01 1.83e-01 3.53e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 2.20e-01 1.83e-01 3.53e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 3.17e-01 -1.83e-01 4.56e-01
Anchoring of the basal body to the plasma membrane 96 2.06e-03 -1.82e-01 8.32e-03
Regulation of BACH1 activity 11 2.97e-01 -1.82e-01 4.34e-01
CTLA4 inhibitory signaling 20 1.60e-01 -1.82e-01 2.77e-01
Formation of the beta-catenin:TCF transactivating complex 41 4.47e-02 -1.81e-01 1.03e-01
Smooth Muscle Contraction 37 5.68e-02 1.81e-01 1.25e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 2.69e-02 -1.81e-01 6.84e-02
Cytosolic sensors of pathogen-associated DNA 63 1.32e-02 -1.81e-01 4.00e-02
Platelet Aggregation (Plug Formation) 34 6.86e-02 -1.80e-01 1.45e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 1.26e-02 -1.80e-01 3.84e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 3.01e-01 1.80e-01 4.39e-01
RNA Polymerase I Transcription Termination 30 8.78e-02 1.80e-01 1.73e-01
Golgi Associated Vesicle Biogenesis 55 2.10e-02 -1.80e-01 5.74e-02
CLEC7A (Dectin-1) signaling 96 2.45e-03 -1.79e-01 9.51e-03
Regulation of mRNA stability by proteins that bind AU-rich elements 87 3.95e-03 -1.79e-01 1.42e-02
SCF-beta-TrCP mediated degradation of Emi1 53 2.44e-02 -1.79e-01 6.34e-02
ERBB2 Regulates Cell Motility 14 2.48e-01 1.78e-01 3.84e-01
MAP kinase activation 63 1.44e-02 -1.78e-01 4.30e-02
Biosynthesis of specialized proresolving mediators (SPMs) 17 2.04e-01 -1.78e-01 3.32e-01
Immune System 1741 1.50e-34 -1.78e-01 7.48e-32
TP53 Regulates Transcription of DNA Repair Genes 61 1.64e-02 -1.78e-01 4.70e-02
Synthesis of IP3 and IP4 in the cytosol 24 1.32e-01 -1.77e-01 2.38e-01
Apoptotic execution phase 44 4.21e-02 -1.77e-01 9.83e-02
tRNA processing 109 1.41e-03 -1.77e-01 6.00e-03
SCF(Skp2)-mediated degradation of p27/p21 60 1.79e-02 -1.77e-01 4.99e-02
Regulation of ornithine decarboxylase (ODC) 48 3.53e-02 -1.76e-01 8.51e-02
Advanced glycosylation endproduct receptor signaling 12 2.92e-01 -1.76e-01 4.30e-01
Potential therapeutics for SARS 101 2.32e-03 -1.75e-01 9.19e-03
Heme signaling 45 4.21e-02 -1.75e-01 9.83e-02
RHOBTB1 GTPase cycle 23 1.46e-01 -1.75e-01 2.59e-01
Assembly and cell surface presentation of NMDA receptors 36 6.95e-02 1.75e-01 1.46e-01
p53-Dependent G1 DNA Damage Response 63 1.65e-02 -1.75e-01 4.70e-02
p53-Dependent G1/S DNA damage checkpoint 63 1.65e-02 -1.75e-01 4.70e-02
C-type lectin receptors (CLRs) 125 7.96e-04 -1.74e-01 3.66e-03
Disorders of Developmental Biology 13 2.80e-01 -1.73e-01 4.17e-01
Disorders of Nervous System Development 13 2.80e-01 -1.73e-01 4.17e-01
Loss of function of MECP2 in Rett syndrome 13 2.80e-01 -1.73e-01 4.17e-01
Pervasive developmental disorders 13 2.80e-01 -1.73e-01 4.17e-01
Adaptive Immune System 696 8.46e-15 -1.73e-01 3.42e-13
Gene expression (Transcription) 1395 4.77e-27 -1.73e-01 1.02e-24
Uptake and function of anthrax toxins 11 3.24e-01 -1.72e-01 4.63e-01
Nucleotide salvage 22 1.64e-01 -1.71e-01 2.83e-01
Respiratory electron transport 93 4.30e-03 1.71e-01 1.53e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.80e-02 -1.71e-01 7.01e-02
Cytokine Signaling in Immune system 620 3.70e-13 -1.71e-01 1.13e-11
Global Genome Nucleotide Excision Repair (GG-NER) 84 6.84e-03 -1.71e-01 2.32e-02
Neuronal System 287 6.76e-07 1.71e-01 7.12e-06
Regulation of PTEN gene transcription 60 2.24e-02 -1.70e-01 6.00e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 113 1.80e-03 -1.70e-01 7.40e-03
Gap junction assembly 19 2.00e-01 1.70e-01 3.28e-01
Signaling by Retinoic Acid 38 6.98e-02 1.70e-01 1.46e-01
FOXO-mediated transcription of cell cycle genes 15 2.56e-01 -1.69e-01 3.91e-01
PPARA activates gene expression 105 2.74e-03 -1.69e-01 1.04e-02
Regulation of lipid metabolism by PPARalpha 107 2.50e-03 -1.69e-01 9.69e-03
Cardiogenesis 20 1.91e-01 1.69e-01 3.20e-01
CD209 (DC-SIGN) signaling 20 1.91e-01 -1.69e-01 3.20e-01
Stabilization of p53 54 3.19e-02 -1.69e-01 7.87e-02
Infection with Mycobacterium tuberculosis 27 1.29e-01 -1.69e-01 2.34e-01
EPHA-mediated growth cone collapse 24 1.54e-01 1.68e-01 2.70e-01
HIV elongation arrest and recovery 32 1.01e-01 -1.67e-01 1.94e-01
Pausing and recovery of HIV elongation 32 1.01e-01 -1.67e-01 1.94e-01
Trafficking of GluR2-containing AMPA receptors 16 2.47e-01 1.67e-01 3.84e-01
Phospholipid metabolism 186 8.69e-05 -1.67e-01 5.12e-04
Degradation of beta-catenin by the destruction complex 83 8.61e-03 -1.67e-01 2.80e-02
Rab regulation of trafficking 121 1.54e-03 -1.67e-01 6.45e-03
Constitutive Signaling by AKT1 E17K in Cancer 26 1.43e-01 -1.66e-01 2.55e-01
Plasma lipoprotein assembly 11 3.41e-01 1.66e-01 4.80e-01
Gap junction trafficking 30 1.18e-01 1.65e-01 2.18e-01
NR1H2 and NR1H3-mediated signaling 41 6.79e-02 -1.65e-01 1.44e-01
TNFR1-induced NF-kappa-B signaling pathway 33 1.04e-01 -1.64e-01 1.97e-01
Interleukin-17 signaling 67 2.11e-02 -1.63e-01 5.74e-02
Negative regulation of NOTCH4 signaling 54 3.84e-02 -1.63e-01 9.12e-02
Defective CFTR causes cystic fibrosis 58 3.26e-02 -1.62e-01 8.00e-02
IRS-mediated signalling 37 8.77e-02 -1.62e-01 1.73e-01
SARS-CoV Infections 385 4.95e-08 -1.62e-01 6.92e-07
Signaling by FGFR2 IIIa TM 19 2.21e-01 1.62e-01 3.54e-01
Disorders of transmembrane transporters 143 8.32e-04 -1.62e-01 3.75e-03
ESR-mediated signaling 162 3.79e-04 -1.62e-01 1.90e-03
Regulated Necrosis 56 3.62e-02 -1.62e-01 8.67e-02
Intraflagellar transport 49 5.00e-02 1.62e-01 1.12e-01
Glycosphingolipid metabolism 36 9.30e-02 1.62e-01 1.80e-01
Negative regulation of FLT3 15 2.78e-01 -1.62e-01 4.17e-01
Synthesis, secretion, and deacylation of Ghrelin 13 3.13e-01 -1.61e-01 4.52e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 1.39e-01 -1.61e-01 2.49e-01
Protein ubiquitination 67 2.27e-02 -1.61e-01 6.07e-02
RNA Polymerase II Transcription 1236 3.28e-21 -1.61e-01 3.27e-19
Amyloid fiber formation 46 5.98e-02 -1.60e-01 1.31e-01
Nicotinate metabolism 27 1.49e-01 -1.60e-01 2.64e-01
Formation of annular gap junctions 11 3.58e-01 1.60e-01 4.98e-01
RNA polymerase II transcribes snRNA genes 71 1.97e-02 -1.60e-01 5.45e-02
Norepinephrine Neurotransmitter Release Cycle 15 2.83e-01 1.60e-01 4.22e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 3.37e-01 -1.60e-01 4.77e-01
PERK regulates gene expression 32 1.17e-01 -1.60e-01 2.18e-01
RHOD GTPase cycle 52 4.63e-02 -1.60e-01 1.05e-01
Inositol phosphate metabolism 45 6.38e-02 -1.60e-01 1.37e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 3.45e-03 1.59e-01 1.27e-02
Vif-mediated degradation of APOBEC3G 52 4.71e-02 -1.59e-01 1.07e-01
Pre-NOTCH Expression and Processing 60 3.30e-02 -1.59e-01 8.07e-02
Biosynthesis of DHA-derived SPMs 15 2.87e-01 -1.59e-01 4.26e-01
Serotonin Neurotransmitter Release Cycle 16 2.72e-01 1.59e-01 4.10e-01
Programmed Cell Death 196 1.30e-04 -1.59e-01 7.44e-04
Phase 2 - plateau phase 10 3.88e-01 1.58e-01 5.28e-01
SHC-mediated cascade:FGFR2 14 3.07e-01 1.58e-01 4.45e-01
Downstream signaling events of B Cell Receptor (BCR) 79 1.54e-02 -1.58e-01 4.56e-02
Transcription of the HIV genome 67 2.61e-02 -1.57e-01 6.68e-02
Germ layer formation at gastrulation 11 3.67e-01 1.57e-01 5.07e-01
Cellular response to chemical stress 184 2.44e-04 -1.57e-01 1.30e-03
Negative epigenetic regulation of rRNA expression 60 3.57e-02 -1.57e-01 8.58e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 6.03e-02 -1.57e-01 1.31e-01
ABC-family proteins mediated transport 94 8.65e-03 -1.57e-01 2.81e-02
Cytochrome P450 - arranged by substrate type 39 9.25e-02 1.56e-01 1.79e-01
NIK–>noncanonical NF-kB signaling 57 4.21e-02 -1.56e-01 9.83e-02
GRB2 events in EGFR signaling 12 3.51e-01 -1.56e-01 4.91e-01
Retrograde transport at the Trans-Golgi-Network 49 5.99e-02 -1.55e-01 1.31e-01
TBC/RABGAPs 45 7.15e-02 -1.55e-01 1.49e-01
VxPx cargo-targeting to cilium 18 2.54e-01 -1.55e-01 3.89e-01
Calnexin/calreticulin cycle 26 1.71e-01 -1.55e-01 2.93e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 1.64e-01 -1.55e-01 2.84e-01
Signaling by WNT in cancer 30 1.43e-01 -1.55e-01 2.55e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 3.98e-01 -1.54e-01 5.38e-01
Signaling by ERBB2 TMD/JMD mutants 21 2.22e-01 1.54e-01 3.54e-01
Glucagon-type ligand receptors 21 2.22e-01 1.54e-01 3.54e-01
MTOR signalling 40 9.24e-02 -1.54e-01 1.79e-01
RNA Polymerase II Pre-transcription Events 77 2.01e-02 -1.53e-01 5.53e-02
Glycogen synthesis 13 3.39e-01 1.53e-01 4.78e-01
SARS-CoV-1 Infection 137 2.00e-03 -1.53e-01 8.10e-03
Peroxisomal lipid metabolism 27 1.70e-01 -1.53e-01 2.92e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.48e-01 -1.52e-01 2.62e-01
IRS-related events triggered by IGF1R 40 9.53e-02 -1.52e-01 1.84e-01
Listeria monocytogenes entry into host cells 19 2.55e-01 -1.51e-01 3.89e-01
Regulation of Apoptosis 51 6.24e-02 -1.51e-01 1.34e-01
NOTCH3 Intracellular Domain Regulates Transcription 23 2.13e-01 -1.50e-01 3.44e-01
Signaling by NODAL 13 3.49e-01 -1.50e-01 4.89e-01
SHC-mediated cascade:FGFR3 12 3.69e-01 1.50e-01 5.09e-01
SARS-CoV-1-host interactions 94 1.22e-02 -1.50e-01 3.75e-02
AKT phosphorylates targets in the nucleus 10 4.13e-01 -1.50e-01 5.52e-01
Class I MHC mediated antigen processing & presentation 353 1.50e-06 -1.49e-01 1.41e-05
Downregulation of ERBB2:ERBB3 signaling 13 3.53e-01 1.49e-01 4.93e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 7.22e-02 -1.48e-01 1.50e-01
Semaphorin interactions 63 4.20e-02 1.48e-01 9.83e-02
Nucleotide catabolism 26 1.91e-01 -1.48e-01 3.20e-01
Negative regulation of FGFR2 signaling 25 2.00e-01 1.48e-01 3.28e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 635 2.53e-10 -1.47e-01 5.22e-09
Visual phototransduction 62 4.49e-02 1.47e-01 1.03e-01
Dopamine Neurotransmitter Release Cycle 21 2.44e-01 1.47e-01 3.80e-01
Cristae formation 29 1.71e-01 1.47e-01 2.93e-01
Apoptosis 167 1.08e-03 -1.47e-01 4.75e-03
Dectin-2 family 16 3.10e-01 -1.47e-01 4.49e-01
Transcriptional activation of mitochondrial biogenesis 51 7.03e-02 -1.47e-01 1.47e-01
SUMOylation of DNA methylation proteins 16 3.13e-01 -1.46e-01 4.52e-01
Regulation of NPAS4 gene expression 12 3.82e-01 -1.46e-01 5.24e-01
Signaling by NTRK3 (TRKC) 16 3.14e-01 1.45e-01 4.52e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.37e-01 -1.45e-01 2.46e-01
Mitochondrial calcium ion transport 22 2.39e-01 -1.45e-01 3.74e-01
PKA activation in glucagon signalling 15 3.31e-01 1.45e-01 4.69e-01
Peptide chain elongation 88 1.89e-02 1.45e-01 5.25e-02
GPER1 signaling 38 1.23e-01 1.45e-01 2.26e-01
Signaling by Rho GTPases 620 1.08e-09 -1.44e-01 1.91e-08
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 7.35e-02 -1.44e-01 1.53e-01
Generic Transcription Pathway 1118 7.79e-16 -1.43e-01 3.76e-14
Negative regulation of FGFR3 signaling 23 2.35e-01 1.43e-01 3.70e-01
Regulation of HSF1-mediated heat shock response 78 2.90e-02 -1.43e-01 7.20e-02
Viral Infection Pathways 675 2.72e-10 -1.43e-01 5.42e-09
mTORC1-mediated signalling 24 2.26e-01 -1.43e-01 3.60e-01
Eukaryotic Translation Elongation 93 1.75e-02 1.43e-01 4.90e-02
IGF1R signaling cascade 41 1.14e-01 -1.43e-01 2.13e-01
Degradation of GLI1 by the proteasome 57 6.31e-02 -1.42e-01 1.36e-01
Amino acid transport across the plasma membrane 23 2.38e-01 -1.42e-01 3.73e-01
Insulin receptor signalling cascade 42 1.12e-01 -1.42e-01 2.09e-01
PTEN Regulation 139 3.93e-03 -1.42e-01 1.42e-02
Insulin receptor recycling 26 2.11e-01 1.42e-01 3.43e-01
Viral mRNA Translation 88 2.18e-02 1.41e-01 5.88e-02
ER to Golgi Anterograde Transport 143 3.57e-03 1.41e-01 1.30e-02
GAB1 signalosome 16 3.28e-01 -1.41e-01 4.67e-01
Transferrin endocytosis and recycling 28 1.97e-01 1.41e-01 3.26e-01
Glucose metabolism 84 2.61e-02 -1.41e-01 6.67e-02
Translation of Structural Proteins 9683701 29 1.92e-01 -1.40e-01 3.20e-01
Hh mutants are degraded by ERAD 53 7.92e-02 -1.39e-01 1.61e-01
Glutathione synthesis and recycling 11 4.24e-01 -1.39e-01 5.60e-01
Signaling by Interleukins 404 1.62e-06 -1.39e-01 1.46e-05
SARS-CoV-2 Infection 265 9.98e-05 -1.39e-01 5.78e-04
Degradation of AXIN 53 8.04e-02 -1.39e-01 1.62e-01
RHOF GTPase cycle 40 1.29e-01 -1.39e-01 2.33e-01
Constitutive Signaling by EGFRvIII 15 3.52e-01 -1.39e-01 4.93e-01
Signaling by EGFRvIII in Cancer 15 3.52e-01 -1.39e-01 4.93e-01
Paracetamol ADME 19 2.95e-01 -1.39e-01 4.33e-01
Assembly of active LPL and LIPC lipase complexes 13 3.87e-01 1.39e-01 5.28e-01
Antigen processing: Ubiquitination & Proteasome degradation 291 5.00e-05 -1.38e-01 3.14e-04
Dectin-1 mediated noncanonical NF-kB signaling 58 6.85e-02 -1.38e-01 1.45e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 69 4.76e-02 -1.38e-01 1.08e-01
RHO GTPases Activate WASPs and WAVEs 36 1.53e-01 -1.38e-01 2.68e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 6.09e-02 -1.38e-01 1.32e-01
Common Pathway of Fibrin Clot Formation 12 4.10e-01 1.37e-01 5.49e-01
RAC2 GTPase cycle 87 2.70e-02 -1.37e-01 6.84e-02
Regulation of TP53 Activity through Association with Co-factors 12 4.11e-01 1.37e-01 5.49e-01
Regulation of FZD by ubiquitination 18 3.15e-01 1.37e-01 4.53e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 2.37e-01 1.37e-01 3.73e-01
B-WICH complex positively regulates rRNA expression 42 1.26e-01 -1.36e-01 2.30e-01
XBP1(S) activates chaperone genes 48 1.02e-01 1.36e-01 1.95e-01
RHO GTPases activate CIT 19 3.04e-01 -1.36e-01 4.41e-01
Glycogen storage diseases 14 3.79e-01 1.36e-01 5.21e-01
Transmission across Chemical Synapses 196 1.14e-03 1.35e-01 4.99e-03
G beta:gamma signalling through PI3Kgamma 21 2.85e-01 -1.35e-01 4.24e-01
Cell-Cell communication 121 1.06e-02 1.35e-01 3.31e-02
Chemokine receptors bind chemokines 38 1.52e-01 -1.34e-01 2.68e-01
Negative regulation of MAPK pathway 42 1.33e-01 -1.34e-01 2.38e-01
SUMOylation of intracellular receptors 27 2.28e-01 -1.34e-01 3.62e-01
Termination of O-glycan biosynthesis 14 3.85e-01 1.34e-01 5.27e-01
Interconversion of nucleotide di- and triphosphates 28 2.20e-01 -1.34e-01 3.53e-01
Pausing and recovery of Tat-mediated HIV elongation 30 2.05e-01 -1.34e-01 3.33e-01
Tat-mediated HIV elongation arrest and recovery 30 2.05e-01 -1.34e-01 3.33e-01
Negative regulation of FGFR1 signaling 25 2.48e-01 1.33e-01 3.84e-01
Vpu mediated degradation of CD4 50 1.03e-01 -1.33e-01 1.96e-01
IRE1alpha activates chaperones 50 1.03e-01 1.33e-01 1.96e-01
E3 ubiquitin ligases ubiquitinate target proteins 47 1.15e-01 -1.33e-01 2.14e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.19e-01 -1.33e-01 2.20e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 1.68e-01 -1.33e-01 2.90e-01
Free fatty acids regulate insulin secretion 10 4.68e-01 -1.33e-01 6.02e-01
PI3K Cascade 33 1.88e-01 -1.32e-01 3.17e-01
IKK complex recruitment mediated by RIP1 23 2.74e-01 -1.32e-01 4.12e-01
TP53 Regulates Transcription of Cell Death Genes 42 1.41e-01 -1.31e-01 2.52e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 34 1.86e-01 -1.31e-01 3.13e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 3.96e-01 1.31e-01 5.36e-01
PI3K events in ERBB2 signaling 15 3.81e-01 1.31e-01 5.23e-01
NoRC negatively regulates rRNA expression 57 9.01e-02 -1.30e-01 1.76e-01
GLI3 is processed to GLI3R by the proteasome 57 9.16e-02 -1.29e-01 1.78e-01
Degradation of GLI2 by the proteasome 57 9.21e-02 -1.29e-01 1.79e-01
Sema4D in semaphorin signaling 24 2.74e-01 1.29e-01 4.13e-01
N-Glycan antennae elongation 13 4.22e-01 -1.29e-01 5.60e-01
Activation of HOX genes during differentiation 71 6.19e-02 -1.28e-01 1.34e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 71 6.19e-02 -1.28e-01 1.34e-01
Neurotransmitter receptors and postsynaptic signal transmission 147 7.38e-03 1.28e-01 2.47e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.09e-01 -1.27e-01 2.05e-01
Reduction of cytosolic Ca++ levels 10 4.86e-01 1.27e-01 6.17e-01
Aflatoxin activation and detoxification 14 4.11e-01 -1.27e-01 5.49e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 1.10e-01 -1.27e-01 2.07e-01
TNF signaling 57 9.87e-02 -1.26e-01 1.89e-01
PI-3K cascade:FGFR2 14 4.14e-01 1.26e-01 5.52e-01
Cytosolic iron-sulfur cluster assembly 13 4.34e-01 -1.25e-01 5.69e-01
ATF6 (ATF6-alpha) activates chaperones 12 4.53e-01 1.25e-01 5.89e-01
Synthesis of substrates in N-glycan biosythesis 59 9.67e-02 1.25e-01 1.86e-01
Cargo recognition for clathrin-mediated endocytosis 97 3.38e-02 -1.25e-01 8.19e-02
PIP3 activates AKT signaling 252 6.58e-04 -1.25e-01 3.09e-03
SHC1 events in EGFR signaling 13 4.38e-01 -1.24e-01 5.73e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 4.56e-01 1.24e-01 5.92e-01
CaMK IV-mediated phosphorylation of CREB 10 4.97e-01 -1.24e-01 6.26e-01
Trafficking and processing of endosomal TLR 13 4.39e-01 -1.24e-01 5.75e-01
Platelet Adhesion to exposed collagen 15 4.06e-01 -1.24e-01 5.47e-01
Platelet degranulation 113 2.37e-02 1.23e-01 6.24e-02
Metabolism of polyamines 56 1.11e-01 -1.23e-01 2.09e-01
Regulation of RUNX3 expression and activity 55 1.15e-01 -1.23e-01 2.14e-01
FRS-mediated FGFR2 signaling 16 3.95e-01 1.23e-01 5.36e-01
RAC3 GTPase cycle 89 4.59e-02 -1.22e-01 1.04e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 3.21e-01 1.22e-01 4.59e-01
Class I peroxisomal membrane protein import 20 3.49e-01 -1.21e-01 4.89e-01
Pyroptosis 25 2.96e-01 -1.21e-01 4.33e-01
COPII-mediated vesicle transport 66 8.98e-02 1.21e-01 1.76e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 3.39e-01 1.21e-01 4.78e-01
VEGFR2 mediated cell proliferation 19 3.63e-01 1.20e-01 5.04e-01
Infectious disease 856 3.06e-09 -1.20e-01 4.82e-08
Apoptotic cleavage of cellular proteins 36 2.14e-01 -1.20e-01 3.46e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.02e-01 -1.19e-01 4.40e-01
Transport of connexons to the plasma membrane 13 4.60e-01 1.18e-01 5.94e-01
SRP-dependent cotranslational protein targeting to membrane 111 3.12e-02 1.18e-01 7.72e-02
Glycerophospholipid biosynthesis 109 3.28e-02 -1.18e-01 8.04e-02
RUNX3 regulates p14-ARF 10 5.18e-01 -1.18e-01 6.42e-01
Response to elevated platelet cytosolic Ca2+ 117 2.74e-02 1.18e-01 6.90e-02
COPI-independent Golgi-to-ER retrograde traffic 44 1.76e-01 -1.18e-01 2.99e-01
Signaling by MET 75 7.81e-02 1.18e-01 1.59e-01
Formation of ATP by chemiosmotic coupling 16 4.17e-01 1.17e-01 5.55e-01
ABC transporter disorders 71 8.94e-02 -1.17e-01 1.75e-01
Azathioprine ADME 19 3.79e-01 -1.17e-01 5.21e-01
Oncogenic MAPK signaling 76 7.94e-02 -1.16e-01 1.61e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 2.34e-01 1.16e-01 3.70e-01
FGFR2 alternative splicing 24 3.25e-01 -1.16e-01 4.64e-01
Killing mechanisms 10 5.26e-01 1.16e-01 6.47e-01
WNT5:FZD7-mediated leishmania damping 10 5.26e-01 1.16e-01 6.47e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 42 1.94e-01 -1.16e-01 3.23e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.17e-01 -1.16e-01 4.56e-01
Ubiquitin-dependent degradation of Cyclin D 50 1.59e-01 -1.15e-01 2.77e-01
Formation of Incision Complex in GG-NER 43 1.92e-01 -1.15e-01 3.20e-01
Cytosolic sulfonation of small molecules 19 3.88e-01 1.14e-01 5.29e-01
Purine catabolism 13 4.76e-01 1.14e-01 6.10e-01
Bacterial Infection Pathways 67 1.06e-01 -1.14e-01 2.01e-01
Plasma lipoprotein remodeling 21 3.69e-01 1.13e-01 5.09e-01
PI-3K cascade:FGFR3 12 4.97e-01 1.13e-01 6.27e-01
SHC1 events in ERBB2 signaling 21 3.70e-01 1.13e-01 5.09e-01
Signaling by ALK 26 3.21e-01 -1.12e-01 4.59e-01
GABA synthesis, release, reuptake and degradation 13 4.83e-01 1.12e-01 6.15e-01
RHOBTB GTPase Cycle 35 2.52e-01 -1.12e-01 3.86e-01
Clathrin-mediated endocytosis 137 2.39e-02 -1.12e-01 6.26e-02
Formation of tubulin folding intermediates by CCT/TriC 20 3.89e-01 -1.11e-01 5.29e-01
FRS-mediated FGFR3 signaling 14 4.71e-01 1.11e-01 6.05e-01
The canonical retinoid cycle in rods (twilight vision) 12 5.06e-01 1.11e-01 6.32e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 4.57e-01 -1.11e-01 5.92e-01
RHOBTB2 GTPase cycle 23 3.59e-01 -1.11e-01 4.99e-01
Diseases of carbohydrate metabolism 29 3.03e-01 1.11e-01 4.40e-01
Surfactant metabolism 17 4.30e-01 -1.11e-01 5.66e-01
Regulation of insulin secretion 66 1.21e-01 1.10e-01 2.24e-01
Selenocysteine synthesis 92 6.78e-02 1.10e-01 1.44e-01
RHOJ GTPase cycle 54 1.61e-01 -1.10e-01 2.80e-01
Selenoamino acid metabolism 115 4.18e-02 1.10e-01 9.83e-02
Degradation of DVL 55 1.59e-01 -1.10e-01 2.77e-01
Metabolism of cofactors 19 4.08e-01 1.10e-01 5.49e-01
Incretin synthesis, secretion, and inactivation 14 4.78e-01 1.10e-01 6.12e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 14 4.78e-01 1.10e-01 6.12e-01
HSF1 activation 25 3.44e-01 1.09e-01 4.83e-01
Early SARS-CoV-2 Infection Events 33 2.77e-01 1.09e-01 4.16e-01
Nervous system development 526 1.94e-05 1.09e-01 1.31e-04
PKA activation 16 4.51e-01 1.09e-01 5.87e-01
Nephrin family interactions 20 4.00e-01 1.09e-01 5.40e-01
RHOA GTPase cycle 145 2.52e-02 -1.08e-01 6.49e-02
Regulation of Complement cascade 41 2.34e-01 1.07e-01 3.70e-01
G beta:gamma signalling through CDC42 16 4.57e-01 -1.07e-01 5.92e-01
Signaling by NOTCH4 81 9.54e-02 -1.07e-01 1.84e-01
Somitogenesis 50 1.91e-01 -1.07e-01 3.20e-01
Glutamate and glutamine metabolism 11 5.40e-01 1.07e-01 6.59e-01
RHO GTPases Activate ROCKs 19 4.23e-01 -1.06e-01 5.60e-01
The citric acid (TCA) cycle and respiratory electron transport 160 2.13e-02 1.06e-01 5.76e-02
Neurotransmitter release cycle 38 2.63e-01 1.05e-01 4.01e-01
SLC-mediated transmembrane transport 172 1.79e-02 1.05e-01 4.99e-02
RNA Polymerase I Promoter Clearance 61 1.58e-01 -1.05e-01 2.75e-01
RNA Polymerase I Transcription 61 1.58e-01 -1.05e-01 2.75e-01
Formation of paraxial mesoderm 62 1.55e-01 -1.04e-01 2.71e-01
ABC transporters in lipid homeostasis 14 5.00e-01 -1.04e-01 6.28e-01
Eukaryotic Translation Termination 92 8.53e-02 1.04e-01 1.69e-01
Axon guidance 506 6.76e-05 1.04e-01 4.10e-04
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 4.61e-01 1.03e-01 5.94e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.21e-01 -1.03e-01 4.59e-01
Activation of kainate receptors upon glutamate binding 24 3.83e-01 1.03e-01 5.24e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.54e-01 1.03e-01 4.94e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.54e-01 1.03e-01 4.94e-01
SHC-mediated cascade:FGFR1 13 5.21e-01 1.03e-01 6.44e-01
MAPK6/MAPK4 signaling 85 1.02e-01 -1.03e-01 1.95e-01
The role of Nef in HIV-1 replication and disease pathogenesis 26 3.67e-01 -1.02e-01 5.07e-01
Signalling to ERKs 33 3.11e-01 -1.02e-01 4.51e-01
Ion channel transport 147 3.34e-02 1.02e-01 8.14e-02
p75NTR recruits signalling complexes 13 5.26e-01 1.02e-01 6.47e-01
Signaling by Nuclear Receptors 227 8.43e-03 -1.02e-01 2.75e-02
PKA-mediated phosphorylation of CREB 18 4.57e-01 1.01e-01 5.92e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 27 3.62e-01 1.01e-01 5.03e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 9.09e-02 1.01e-01 1.78e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 8.15e-02 1.01e-01 1.64e-01
Interleukin-10 signaling 36 2.96e-01 -1.01e-01 4.33e-01
Intracellular signaling by second messengers 289 3.34e-03 -1.00e-01 1.24e-02
RHOC GTPase cycle 71 1.44e-01 -1.00e-01 2.55e-01
Kinesins 50 2.20e-01 -1.00e-01 3.53e-01
p130Cas linkage to MAPK signaling for integrins 12 5.48e-01 -1.00e-01 6.65e-01
Signaling by Non-Receptor Tyrosine Kinases 52 2.12e-01 1.00e-01 3.43e-01
Signaling by PTK6 52 2.12e-01 1.00e-01 3.43e-01
NF-kB is activated and signals survival 13 5.33e-01 9.99e-02 6.53e-01
trans-Golgi Network Vesicle Budding 70 1.49e-01 -9.98e-02 2.63e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 5.20e-01 9.94e-02 6.44e-01
Signaling by FGFR1 41 2.71e-01 9.93e-02 4.10e-01
Hh mutants abrogate ligand secretion 56 2.00e-01 -9.91e-02 3.28e-01
Citric acid cycle (TCA cycle) 22 4.23e-01 -9.88e-02 5.60e-01
Regulation of PTEN stability and activity 67 1.63e-01 -9.86e-02 2.82e-01
mRNA Capping 29 3.61e-01 9.80e-02 5.02e-01
BBSome-mediated cargo-targeting to cilium 21 4.37e-01 9.79e-02 5.73e-01
Mitochondrial protein import 63 1.81e-01 9.75e-02 3.06e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 74 1.48e-01 9.73e-02 2.62e-01
Transcriptional regulation of pluripotent stem cells 20 4.53e-01 9.69e-02 5.89e-01
Response of Mtb to phagocytosis 23 4.24e-01 -9.64e-02 5.60e-01
Regulation of RUNX1 Expression and Activity 18 4.79e-01 -9.64e-02 6.12e-01
Cellular hexose transport 16 5.05e-01 9.63e-02 6.32e-01
TNFs bind their physiological receptors 25 4.04e-01 9.63e-02 5.45e-01
Mitochondrial translation initiation 88 1.19e-01 9.61e-02 2.20e-01
RNA Polymerase III Transcription Termination 23 4.27e-01 9.57e-02 5.63e-01
Synthesis of PC 25 4.09e-01 -9.55e-02 5.49e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 5.52e-01 9.52e-02 6.69e-01
Cellular responses to stress 703 1.84e-05 -9.51e-02 1.25e-04
Intrinsic Pathway of Fibrin Clot Formation 15 5.25e-01 -9.47e-02 6.47e-01
Glucagon signaling in metabolic regulation 26 4.04e-01 9.46e-02 5.44e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 3.95e-01 -9.46e-02 5.36e-01
Transcriptional regulation by RUNX2 116 7.92e-02 9.44e-02 1.61e-01
Formation of a pool of free 40S subunits 100 1.04e-01 9.41e-02 1.97e-01
TCF dependent signaling in response to WNT 171 3.43e-02 -9.39e-02 8.29e-02
Regulation of innate immune responses to cytosolic DNA 14 5.43e-01 -9.39e-02 6.62e-01
Signaling by NOTCH 184 2.83e-02 -9.38e-02 7.08e-02
The NLRP3 inflammasome 16 5.18e-01 -9.34e-02 6.42e-01
Transport to the Golgi and subsequent modification 168 3.70e-02 9.33e-02 8.84e-02
RHOV GTPase cycle 36 3.33e-01 -9.33e-02 4.71e-01
COPI-dependent Golgi-to-ER retrograde traffic 89 1.29e-01 9.30e-02 2.34e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 13 5.62e-01 -9.28e-02 6.80e-01
Glycogen metabolism 24 4.32e-01 9.27e-02 5.68e-01
Downstream signal transduction 28 3.99e-01 -9.21e-02 5.39e-01
Signalling to RAS 20 4.76e-01 9.20e-02 6.11e-01
Glyoxylate metabolism and glycine degradation 25 4.26e-01 9.20e-02 5.62e-01
TGF-beta receptor signaling activates SMADs 45 2.86e-01 9.20e-02 4.24e-01
Negative regulation of the PI3K/AKT network 97 1.19e-01 -9.17e-02 2.20e-01
Disease 1525 3.04e-09 -9.15e-02 4.82e-08
Prefoldin mediated transfer of substrate to CCT/TriC 25 4.29e-01 -9.15e-02 5.65e-01
Prostacyclin signalling through prostacyclin receptor 15 5.40e-01 9.13e-02 6.59e-01
Post NMDA receptor activation events 69 1.91e-01 9.11e-02 3.20e-01
Pexophagy 11 6.01e-01 -9.11e-02 7.14e-01
Other interleukin signaling 22 4.60e-01 -9.10e-02 5.94e-01
FCGR3A-mediated phagocytosis 68 1.96e-01 -9.08e-02 3.24e-01
Leishmania phagocytosis 68 1.96e-01 -9.08e-02 3.24e-01
Parasite infection 68 1.96e-01 -9.08e-02 3.24e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 4.94e-01 -9.07e-02 6.24e-01
HIV Transcription Initiation 45 2.93e-01 -9.06e-02 4.30e-01
RNA Polymerase II HIV Promoter Escape 45 2.93e-01 -9.06e-02 4.30e-01
RNA Polymerase II Promoter Escape 45 2.93e-01 -9.06e-02 4.30e-01
RNA Polymerase II Transcription Initiation 45 2.93e-01 -9.06e-02 4.30e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 2.93e-01 -9.06e-02 4.30e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 2.93e-01 -9.06e-02 4.30e-01
Transcriptional Regulation by VENTX 39 3.30e-01 -9.02e-02 4.68e-01
Complement cascade 46 2.91e-01 9.01e-02 4.30e-01
Cytoprotection by HMOX1 58 2.36e-01 -9.00e-02 3.71e-01
RAC1 GTPase cycle 178 3.87e-02 -8.99e-02 9.19e-02
GPCR ligand binding 238 1.74e-02 8.96e-02 4.90e-02
DNA Damage Recognition in GG-NER 38 3.41e-01 -8.92e-02 4.80e-01
Xenobiotics 12 5.93e-01 8.90e-02 7.10e-01
RHO GTPases activate IQGAPs 24 4.53e-01 -8.85e-02 5.89e-01
Cell surface interactions at the vascular wall 129 8.32e-02 -8.84e-02 1.66e-01
Cellular response to heat stress 96 1.35e-01 -8.84e-02 2.42e-01
Other semaphorin interactions 19 5.05e-01 8.83e-02 6.32e-01
PINK1-PRKN Mediated Mitophagy 21 4.84e-01 8.82e-02 6.16e-01
Cellular responses to stimuli 711 6.57e-05 -8.81e-02 4.01e-04
RND2 GTPase cycle 38 3.48e-01 -8.79e-02 4.89e-01
Mitochondrial translation elongation 88 1.56e-01 8.76e-02 2.72e-01
Plasma lipoprotein assembly, remodeling, and clearance 59 2.46e-01 8.74e-02 3.82e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 5.11e-01 -8.71e-02 6.36e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 5.11e-01 -8.71e-02 6.36e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 5.47e-01 -8.70e-02 6.65e-01
Regulation of localization of FOXO transcription factors 11 6.18e-01 -8.69e-02 7.28e-01
Insulin processing 22 4.81e-01 -8.68e-02 6.13e-01
Cellular response to hypoxia 72 2.03e-01 -8.68e-02 3.32e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 4.11e-01 -8.67e-02 5.49e-01
RAB geranylgeranylation 61 2.43e-01 -8.65e-02 3.79e-01
Signaling by EGFR 48 3.01e-01 -8.63e-02 4.39e-01
FCGR activation 21 4.94e-01 -8.62e-02 6.24e-01
Late endosomal microautophagy 32 4.01e-01 8.57e-02 5.41e-01
Nicotinamide salvaging 16 5.53e-01 -8.56e-02 6.70e-01
Activation of NMDA receptors and postsynaptic events 81 1.85e-01 8.52e-02 3.12e-01
Diseases of signal transduction by growth factor receptors and second messengers 402 3.42e-03 -8.52e-02 1.27e-02
Mitochondrial iron-sulfur cluster biogenesis 13 5.96e-01 -8.48e-02 7.11e-01
Ion transport by P-type ATPases 46 3.20e-01 8.47e-02 4.59e-01
Hyaluronan metabolism 17 5.46e-01 8.46e-02 6.64e-01
Transcriptional Regulation by MECP2 55 2.79e-01 -8.45e-02 4.17e-01
Ribavirin ADME 10 6.45e-01 8.41e-02 7.50e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 6.47e-01 8.35e-02 7.52e-01
Regulation of TNFR1 signaling 48 3.18e-01 -8.34e-02 4.56e-01
Mitochondrial tRNA aminoacylation 21 5.09e-01 -8.33e-02 6.35e-01
Transcriptional Regulation by NPAS4 31 4.22e-01 -8.33e-02 5.60e-01
Formation of RNA Pol II elongation complex 56 2.85e-01 -8.26e-02 4.24e-01
RNA Polymerase II Transcription Elongation 56 2.85e-01 -8.26e-02 4.24e-01
RAS processing 23 4.93e-01 8.26e-02 6.24e-01
Interleukin-6 family signaling 22 5.03e-01 8.26e-02 6.30e-01
AKT phosphorylates targets in the cytosol 14 5.93e-01 -8.26e-02 7.09e-01
Regulation of RAS by GAPs 66 2.49e-01 -8.21e-02 3.84e-01
TP53 Regulates Metabolic Genes 80 2.06e-01 -8.19e-02 3.34e-01
Mitochondrial translation 94 1.70e-01 8.19e-02 2.92e-01
Mitochondrial translation termination 88 1.85e-01 8.18e-02 3.12e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 4.98e-01 -8.16e-02 6.27e-01
Metabolism of carbohydrates 261 2.34e-02 8.16e-02 6.19e-02
Regulation of beta-cell development 23 4.99e-01 -8.14e-02 6.27e-01
Asymmetric localization of PCP proteins 62 2.68e-01 -8.14e-02 4.06e-01
Hedgehog ligand biogenesis 61 2.73e-01 -8.12e-02 4.11e-01
Signaling by ERBB2 in Cancer 25 4.85e-01 8.08e-02 6.16e-01
EPH-Ephrin signaling 87 1.94e-01 8.06e-02 3.22e-01
RHOG GTPase cycle 72 2.38e-01 -8.05e-02 3.73e-01
Elevation of cytosolic Ca2+ levels 13 6.17e-01 -8.02e-02 7.28e-01
Cholesterol biosynthesis 26 4.81e-01 7.99e-02 6.13e-01
Cellular response to starvation 150 9.25e-02 7.96e-02 1.79e-01
Role of phospholipids in phagocytosis 33 4.29e-01 -7.95e-02 5.66e-01
rRNA modification in the nucleus and cytosol 59 2.93e-01 -7.92e-02 4.30e-01
Chaperonin-mediated protein folding 77 2.32e-01 -7.88e-02 3.68e-01
Sphingolipid metabolism 76 2.35e-01 7.88e-02 3.70e-01
DARPP-32 events 23 5.13e-01 -7.87e-02 6.38e-01
Asparagine N-linked glycosylation 283 2.30e-02 7.86e-02 6.14e-02
Negative regulation of FGFR4 signaling 23 5.17e-01 7.81e-02 6.42e-01
Sema4D induced cell migration and growth-cone collapse 20 5.48e-01 7.77e-02 6.65e-01
L1CAM interactions 104 1.79e-01 7.63e-02 3.03e-01
Transcriptional regulation by RUNX3 95 1.99e-01 -7.63e-02 3.27e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 6.78e-01 7.59e-02 7.71e-01
Signaling by ERBB2 ECD mutants 16 6.00e-01 -7.57e-02 7.14e-01
Ca2+ pathway 57 3.23e-01 7.56e-02 4.62e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 6.38e-01 7.53e-02 7.47e-01
Phase I - Functionalization of compounds 73 2.67e-01 7.52e-02 4.05e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.72e-01 7.50e-02 2.95e-01
Lysosome Vesicle Biogenesis 33 4.57e-01 -7.48e-02 5.92e-01
Macroautophagy 124 1.53e-01 -7.44e-02 2.68e-01
Post-chaperonin tubulin folding pathway 17 5.96e-01 7.44e-02 7.11e-01
Signaling by TGF-beta Receptor Complex 90 2.23e-01 -7.43e-02 3.56e-01
ADORA2B mediated anti-inflammatory cytokines production 36 4.42e-01 7.40e-02 5.78e-01
Signaling by ERBB2 KD Mutants 24 5.33e-01 7.35e-02 6.53e-01
Drug ADME 61 3.24e-01 -7.31e-02 4.62e-01
FRS-mediated FGFR1 signaling 15 6.25e-01 7.29e-02 7.36e-01
Formation of the Early Elongation Complex 33 4.69e-01 7.29e-02 6.02e-01
Formation of the HIV-1 Early Elongation Complex 33 4.69e-01 7.29e-02 6.02e-01
GRB2 events in ERBB2 signaling 15 6.25e-01 7.28e-02 7.36e-01
Signaling by ERBB2 48 3.83e-01 7.28e-02 5.24e-01
Formation of Fibrin Clot (Clotting Cascade) 25 5.29e-01 -7.28e-02 6.50e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 6.16e-01 -7.24e-02 7.28e-01
Vitamin B5 (pantothenate) metabolism 16 6.18e-01 -7.20e-02 7.28e-01
Cytosolic tRNA aminoacylation 24 5.44e-01 7.15e-02 6.63e-01
Apoptotic factor-mediated response 20 5.81e-01 -7.13e-02 7.00e-01
Signaling by EGFR in Cancer 24 5.48e-01 -7.08e-02 6.65e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 3.29e-01 -7.05e-02 4.68e-01
Detoxification of Reactive Oxygen Species 33 4.83e-01 -7.05e-02 6.15e-01
G-protein activation 19 5.96e-01 7.03e-02 7.11e-01
Stimuli-sensing channels 82 2.73e-01 7.01e-02 4.11e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 90 2.51e-01 -7.00e-02 3.86e-01
Arachidonic acid metabolism 44 4.23e-01 -6.98e-02 5.60e-01
Neddylation 231 6.90e-02 -6.95e-02 1.45e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 5.27e-01 -6.90e-02 6.48e-01
PI-3K cascade:FGFR1 13 6.67e-01 6.89e-02 7.63e-01
Metabolism of lipids 631 3.33e-03 -6.86e-02 1.24e-02
Signaling by FGFR in disease 53 3.88e-01 -6.86e-02 5.29e-01
Thromboxane signalling through TP receptor 20 5.97e-01 6.84e-02 7.11e-01
TNFR2 non-canonical NF-kB pathway 95 2.51e-01 -6.82e-02 3.86e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 4.35e-01 -6.80e-02 5.71e-01
Downstream signaling of activated FGFR2 21 5.90e-01 6.79e-02 7.07e-01
Death Receptor Signaling 150 1.54e-01 -6.75e-02 2.70e-01
Notch-HLH transcription pathway 28 5.40e-01 -6.69e-02 6.59e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 6.17e-01 -6.63e-02 7.28e-01
RNA Polymerase III Chain Elongation 18 6.28e-01 6.60e-02 7.38e-01
Lysine catabolism 11 7.07e-01 -6.54e-02 7.93e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 6.43e-01 -6.50e-02 7.48e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 2.40e-01 6.49e-02 3.75e-01
p75NTR signals via NF-kB 16 6.54e-01 6.48e-02 7.55e-01
Signaling by WNT 259 7.60e-02 -6.41e-02 1.56e-01
Cap-dependent Translation Initiation 118 2.30e-01 6.40e-02 3.66e-01
Eukaryotic Translation Initiation 118 2.30e-01 6.40e-02 3.66e-01
Signaling by Receptor Tyrosine Kinases 479 1.68e-02 6.39e-02 4.77e-02
Acyl chain remodelling of PE 21 6.13e-01 6.37e-02 7.26e-01
Presynaptic function of Kainate receptors 17 6.50e-01 6.36e-02 7.54e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 5.21e-01 6.36e-02 6.44e-01
MicroRNA (miRNA) biogenesis 25 5.84e-01 -6.32e-02 7.02e-01
Initial triggering of complement 25 5.85e-01 6.32e-02 7.02e-01
Autophagy 139 1.99e-01 -6.31e-02 3.27e-01
PI3K/AKT Signaling in Cancer 90 3.01e-01 -6.31e-02 4.39e-01
RHO GTPase cycle 427 2.70e-02 -6.25e-02 6.84e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 7.33e-01 -6.23e-02 8.14e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.92e-01 6.20e-02 6.23e-01
RNA Polymerase III Transcription 41 4.92e-01 6.20e-02 6.23e-01
Signaling by Hippo 20 6.36e-01 -6.12e-02 7.44e-01
Classical antibody-mediated complement activation 14 6.92e-01 6.11e-02 7.83e-01
Constitutive Signaling by Overexpressed ERBB2 11 7.29e-01 -6.02e-02 8.11e-01
Signaling by ALK fusions and activated point mutants 54 4.44e-01 -6.02e-02 5.79e-01
Signaling by ALK in cancer 54 4.44e-01 -6.02e-02 5.79e-01
G alpha (z) signalling events 38 5.21e-01 6.01e-02 6.44e-01
SUMOylation of immune response proteins 11 7.30e-01 -6.01e-02 8.11e-01
Translation of Structural Proteins 9694635 57 4.33e-01 -6.01e-02 5.68e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 7.44e-01 5.96e-02 8.23e-01
Physiological factors 10 7.45e-01 -5.94e-02 8.23e-01
Defective Intrinsic Pathway for Apoptosis 24 6.16e-01 -5.91e-02 7.28e-01
SUMOylation of transcription factors 16 6.83e-01 -5.90e-02 7.75e-01
Hemostasis 529 2.12e-02 -5.87e-02 5.76e-02
Formation of definitive endoderm 11 7.36e-01 5.87e-02 8.16e-01
Branched-chain amino acid catabolism 21 6.42e-01 -5.86e-02 7.48e-01
Developmental Biology 828 4.46e-03 5.84e-02 1.58e-02
RHOB GTPase cycle 67 4.10e-01 -5.82e-02 5.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 14 7.07e-01 -5.80e-02 7.93e-01
Fcgamma receptor (FCGR) dependent phagocytosis 94 3.31e-01 -5.80e-02 4.69e-01
Signaling by NTRK1 (TRKA) 110 2.96e-01 -5.77e-02 4.33e-01
Circadian Clock 67 4.18e-01 -5.73e-02 5.56e-01
MHC class II antigen presentation 100 3.28e-01 -5.66e-02 4.67e-01
Effects of PIP2 hydrolysis 24 6.33e-01 -5.64e-02 7.41e-01
Peroxisomal protein import 58 4.66e-01 -5.53e-02 6.01e-01
Defects in vitamin and cofactor metabolism 21 6.61e-01 5.52e-02 7.57e-01
Translation 292 1.07e-01 5.49e-02 2.02e-01
Protein folding 83 3.90e-01 -5.46e-02 5.30e-01
Josephin domain DUBs 10 7.66e-01 -5.44e-02 8.40e-01
Signaling by Activin 14 7.25e-01 5.44e-02 8.07e-01
G alpha (s) signalling events 95 3.61e-01 5.43e-02 5.02e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 7.67e-01 5.41e-02 8.40e-01
Nucleotide-like (purinergic) receptors 15 7.19e-01 5.37e-02 8.03e-01
Downstream signaling of activated FGFR3 19 6.86e-01 5.36e-02 7.77e-01
Fatty acid metabolism 154 2.55e-01 -5.32e-02 3.89e-01
Recycling pathway of L1 40 5.65e-01 -5.25e-02 6.83e-01
Regulation of CDH11 Expression and Function 25 6.51e-01 5.22e-02 7.54e-01
Diseases associated with N-glycosylation of proteins 20 6.87e-01 5.20e-02 7.78e-01
DAG and IP3 signaling 38 5.80e-01 5.18e-02 6.99e-01
RHO GTPases activate PAKs 21 6.83e-01 -5.15e-02 7.75e-01
Signaling by FGFR2 in disease 34 6.05e-01 5.12e-02 7.18e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 7.15e-01 5.11e-02 8.00e-01
P2Y receptors 11 7.69e-01 -5.10e-02 8.41e-01
Integration of energy metabolism 95 3.91e-01 5.10e-02 5.31e-01
Leishmania infection 161 2.67e-01 -5.07e-02 4.05e-01
Parasitic Infection Pathways 161 2.67e-01 -5.07e-02 4.05e-01
Translation initiation complex formation 58 5.04e-01 -5.07e-02 6.32e-01
Metabolism of vitamins and cofactors 163 2.66e-01 5.05e-02 4.05e-01
Regulation of actin dynamics for phagocytic cup formation 70 4.69e-01 -5.01e-02 6.02e-01
Metabolism of amino acids and derivatives 321 1.25e-01 4.99e-02 2.29e-01
Formation of the cornified envelope 27 6.58e-01 4.92e-02 7.57e-01
Keratinization 27 6.58e-01 4.92e-02 7.57e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 5.14e-01 -4.91e-02 6.39e-01
Formation of TC-NER Pre-Incision Complex 53 5.41e-01 -4.86e-02 6.59e-01
Downstream signaling of activated FGFR1 22 6.95e-01 4.84e-02 7.84e-01
EGFR downregulation 29 6.58e-01 -4.76e-02 7.57e-01
Synthesis of bile acids and bile salts 27 6.70e-01 4.73e-02 7.65e-01
RND3 GTPase cycle 38 6.16e-01 -4.71e-02 7.28e-01
Synthesis of PA 33 6.40e-01 -4.71e-02 7.47e-01
Peptide hormone metabolism 59 5.33e-01 4.70e-02 6.53e-01
Late SARS-CoV-2 Infection Events 67 5.09e-01 -4.67e-02 6.35e-01
RHOQ GTPase cycle 58 5.40e-01 -4.65e-02 6.59e-01
Regulation of RUNX2 expression and activity 70 5.02e-01 -4.64e-02 6.30e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 7.82e-01 4.62e-02 8.53e-01
Acetylcholine regulates insulin secretion 10 8.02e-01 -4.58e-02 8.66e-01
G alpha (12/13) signalling events 70 5.09e-01 4.57e-02 6.35e-01
G beta:gamma signalling through PLC beta 16 7.52e-01 4.57e-02 8.28e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 77 4.91e-01 4.54e-02 6.23e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 6.52e-01 4.54e-02 7.54e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 7.19e-01 -4.53e-02 8.03e-01
Neurodegenerative Diseases 21 7.19e-01 -4.53e-02 8.03e-01
Aggrephagy 33 6.53e-01 4.52e-02 7.55e-01
Aquaporin-mediated transport 36 6.39e-01 4.52e-02 7.47e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 5.94e-01 -4.49e-02 7.10e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 26 6.93e-01 -4.47e-02 7.83e-01
SARS-CoV-2 modulates host translation machinery 49 5.91e-01 -4.44e-02 7.08e-01
NPAS4 regulates expression of target genes 19 7.41e-01 -4.37e-02 8.20e-01
G alpha (q) signalling events 138 3.85e-01 4.28e-02 5.27e-01
RNA Polymerase III Transcription Initiation 36 6.59e-01 4.25e-02 7.57e-01
Plasma lipoprotein clearance 34 6.70e-01 4.23e-02 7.65e-01
Influenza Infection 154 3.68e-01 -4.21e-02 5.08e-01
RET signaling 34 6.73e-01 -4.18e-02 7.67e-01
Ribosomal scanning and start codon recognition 58 5.82e-01 -4.17e-02 7.00e-01
Post-translational protein modification 1229 1.49e-02 -4.15e-02 4.44e-02
ERKs are inactivated 13 7.96e-01 -4.15e-02 8.64e-01
CDC42 GTPase cycle 150 3.81e-01 -4.15e-02 5.23e-01
WNT5A-dependent internalization of FZD4 14 7.91e-01 -4.09e-02 8.60e-01
RND1 GTPase cycle 39 6.58e-01 -4.09e-02 7.57e-01
NGF-stimulated transcription 35 6.76e-01 -4.08e-02 7.69e-01
Membrane Trafficking 588 9.49e-02 -4.04e-02 1.83e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 7.13e-01 4.01e-02 7.99e-01
tRNA modification in the nucleus and cytosol 43 6.51e-01 -3.99e-02 7.54e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 7.90e-01 -3.96e-02 8.60e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 6.60e-01 -3.92e-02 7.57e-01
HIV Transcription Elongation 42 6.60e-01 -3.92e-02 7.57e-01
Tat-mediated elongation of the HIV-1 transcript 42 6.60e-01 -3.92e-02 7.57e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 7.23e-01 3.87e-02 8.07e-01
Unfolded Protein Response (UPR) 92 5.23e-01 3.86e-02 6.45e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 6.39e-01 -3.79e-02 7.47e-01
Iron uptake and transport 55 6.29e-01 3.76e-02 7.39e-01
Platelet homeostasis 74 5.78e-01 3.74e-02 6.97e-01
Carboxyterminal post-translational modifications of tubulin 30 7.25e-01 3.71e-02 8.07e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 16 7.98e-01 -3.70e-02 8.65e-01
Signaling by NOTCH1 72 5.88e-01 -3.69e-02 7.06e-01
Repression of WNT target genes 14 8.11e-01 3.68e-02 8.75e-01
Signaling by GPCR 450 1.83e-01 3.67e-02 3.09e-01
Methylation 13 8.20e-01 -3.65e-02 8.80e-01
Amino acids regulate mTORC1 50 6.56e-01 3.65e-02 7.57e-01
TNFR1-induced proapoptotic signaling 25 7.53e-01 -3.64e-02 8.29e-01
Selective autophagy 70 6.05e-01 3.58e-02 7.18e-01
Regulated proteolysis of p75NTR 11 8.38e-01 -3.57e-02 8.92e-01
Regulation of Expression and Function of Type II Classical Cadherins 27 7.50e-01 3.55e-02 8.26e-01
Regulation of Homotypic Cell-Cell Adhesion 27 7.50e-01 3.55e-02 8.26e-01
Signaling by NTRK2 (TRKB) 23 7.69e-01 -3.54e-02 8.41e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 6.62e-01 -3.54e-02 7.58e-01
NRAGE signals death through JNK 56 6.48e-01 3.53e-02 7.52e-01
p38MAPK events 13 8.27e-01 3.50e-02 8.84e-01
Miscellaneous transport and binding events 22 7.78e-01 -3.48e-02 8.50e-01
Cilium Assembly 187 4.16e-01 -3.45e-02 5.54e-01
Biological oxidations 148 4.81e-01 3.36e-02 6.13e-01
MAPK family signaling cascades 291 3.30e-01 -3.32e-02 4.69e-01
MAPK1/MAPK3 signaling 254 3.65e-01 -3.30e-02 5.06e-01
Transport of bile salts and organic acids, metal ions and amine compounds 48 6.93e-01 3.30e-02 7.83e-01
Signaling by FGFR 72 6.30e-01 3.29e-02 7.39e-01
Metabolic disorders of biological oxidation enzymes 23 7.85e-01 3.28e-02 8.56e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 8.48e-01 -3.20e-02 9.01e-01
Signaling by FGFR3 in disease 16 8.27e-01 3.16e-02 8.84e-01
Glutathione conjugation 30 7.66e-01 3.13e-02 8.40e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 7.10e-01 3.11e-02 7.95e-01
Nuclear Events (kinase and transcription factor activation) 57 6.85e-01 -3.11e-02 7.77e-01
Mitophagy 28 7.83e-01 3.01e-02 8.53e-01
VLDLR internalisation and degradation 16 8.35e-01 3.01e-02 8.90e-01
Signaling by Hedgehog 140 5.40e-01 3.00e-02 6.59e-01
Induction of Cell-Cell Fusion 10 8.70e-01 3.00e-02 9.17e-01
Signal Transduction 2147 2.38e-02 -3.00e-02 6.24e-02
SARS-CoV-1 modulates host translation machinery 36 7.56e-01 2.99e-02 8.32e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 8.01e-01 -2.97e-02 8.66e-01
ADP signalling through P2Y purinoceptor 1 21 8.15e-01 2.96e-02 8.77e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 8.25e-01 2.94e-02 8.84e-01
Downregulation of TGF-beta receptor signaling 26 7.97e-01 2.91e-02 8.65e-01
Transport of small molecules 571 2.36e-01 2.91e-02 3.71e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 7.06e-01 -2.89e-02 7.93e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 7.06e-01 -2.89e-02 7.93e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 7.06e-01 -2.89e-02 7.93e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 7.06e-01 -2.89e-02 7.93e-01
Signaling by NOTCH1 in Cancer 57 7.06e-01 -2.89e-02 7.93e-01
Signal transduction by L1 21 8.20e-01 -2.87e-02 8.80e-01
Organelle biogenesis and maintenance 274 4.14e-01 -2.87e-02 5.52e-01
Opioid Signalling 81 6.57e-01 2.86e-02 7.57e-01
Fertilization 10 8.79e-01 -2.78e-02 9.25e-01
Cargo trafficking to the periciliary membrane 46 7.45e-01 2.77e-02 8.23e-01
Voltage gated Potassium channels 22 8.23e-01 2.76e-02 8.82e-01
Interleukin-37 signaling 20 8.31e-01 2.75e-02 8.86e-01
Signaling by ROBO receptors 207 4.95e-01 2.75e-02 6.26e-01
Golgi-to-ER retrograde transport 122 6.00e-01 2.75e-02 7.14e-01
Signaling by Insulin receptor 67 7.02e-01 -2.70e-02 7.92e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 8.13e-01 2.63e-02 8.76e-01
Metabolism of water-soluble vitamins and cofactors 113 6.30e-01 -2.62e-02 7.39e-01
O-linked glycosylation of mucins 45 7.61e-01 2.62e-02 8.36e-01
Protein methylation 15 8.63e-01 -2.58e-02 9.13e-01
SHC-mediated cascade:FGFR4 12 8.79e-01 2.55e-02 9.25e-01
Post-translational modification: synthesis of GPI-anchored proteins 63 7.27e-01 2.54e-02 8.10e-01
Regulation of expression of SLITs and ROBOs 164 5.76e-01 2.53e-02 6.95e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 6.41e-01 2.53e-02 7.47e-01
Nonsense-Mediated Decay (NMD) 114 6.41e-01 2.53e-02 7.47e-01
Downstream signaling of activated FGFR4 19 8.50e-01 -2.50e-02 9.03e-01
RAF/MAP kinase cascade 248 4.98e-01 -2.50e-02 6.27e-01
TRP channels 21 8.44e-01 2.48e-02 8.98e-01
Thrombin signalling through proteinase activated receptors (PARs) 26 8.30e-01 -2.43e-02 8.86e-01
Signaling by VEGF 104 6.69e-01 2.43e-02 7.64e-01
Vesicle-mediated transport 626 3.02e-01 -2.42e-02 4.40e-01
Signaling by ERBB4 52 7.64e-01 2.41e-02 8.38e-01
Response of EIF2AK1 (HRI) to heme deficiency 15 8.72e-01 2.40e-02 9.19e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 33 8.13e-01 -2.38e-02 8.76e-01
Acyl chain remodelling of PC 21 8.51e-01 -2.37e-02 9.03e-01
Phase II - Conjugation of compounds 70 7.35e-01 2.34e-02 8.15e-01
p75 NTR receptor-mediated signalling 93 7.05e-01 -2.27e-02 7.93e-01
tRNA Aminoacylation 42 7.99e-01 -2.27e-02 8.65e-01
G-protein mediated events 50 7.81e-01 2.27e-02 8.53e-01
Carnitine metabolism 14 8.84e-01 -2.25e-02 9.29e-01
PLC beta mediated events 46 7.92e-01 2.25e-02 8.61e-01
Signaling by FGFR3 34 8.27e-01 2.17e-02 8.84e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.01e-01 2.17e-02 9.41e-01
Metabolism of proteins 1677 1.47e-01 -2.14e-02 2.61e-01
Platelet activation, signaling and aggregation 234 5.73e-01 -2.14e-02 6.92e-01
Peptide ligand-binding receptors 90 7.28e-01 -2.12e-02 8.10e-01
Signaling by NTRKs 127 6.83e-01 -2.10e-02 7.75e-01
Creation of C4 and C2 activators 17 8.82e-01 2.08e-02 9.27e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 8.44e-01 -2.04e-02 8.98e-01
Spry regulation of FGF signaling 16 8.88e-01 -2.04e-02 9.31e-01
FCGR3A-mediated IL10 synthesis 45 8.15e-01 2.02e-02 8.77e-01
Pyruvate metabolism 27 8.61e-01 1.95e-02 9.12e-01
Suppression of phagosomal maturation 13 9.03e-01 1.94e-02 9.43e-01
Degradation of cysteine and homocysteine 13 9.06e-01 1.90e-02 9.44e-01
VEGFR2 mediated vascular permeability 27 8.65e-01 -1.90e-02 9.13e-01
Class A/1 (Rhodopsin-like receptors) 165 6.75e-01 1.90e-02 7.69e-01
Glycogen breakdown (glycogenolysis) 14 9.06e-01 1.82e-02 9.44e-01
Biotin transport and metabolism 11 9.18e-01 -1.79e-02 9.53e-01
PCP/CE pathway 89 7.96e-01 -1.59e-02 8.64e-01
ERK/MAPK targets 22 8.99e-01 -1.57e-02 9.39e-01
Mitochondrial biogenesis 87 8.01e-01 -1.57e-02 8.66e-01
SHC1 events in ERBB4 signaling 13 9.23e-01 1.54e-02 9.57e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 9.18e-01 1.54e-02 9.53e-01
Influenza Viral RNA Transcription and Replication 135 7.59e-01 -1.53e-02 8.34e-01
Signaling by NOTCH3 47 8.59e-01 -1.50e-02 9.11e-01
LDL clearance 18 9.13e-01 -1.49e-02 9.50e-01
PECAM1 interactions 12 9.31e-01 -1.45e-02 9.60e-01
Receptor Mediated Mitophagy 11 9.35e-01 -1.42e-02 9.62e-01
Budding and maturation of HIV virion 28 8.98e-01 -1.40e-02 9.39e-01
RNA Polymerase I Transcription Initiation 47 8.68e-01 1.40e-02 9.16e-01
Blood group systems biosynthesis 16 9.28e-01 -1.30e-02 9.59e-01
Sialic acid metabolism 29 9.05e-01 1.28e-02 9.44e-01
Sulfur amino acid metabolism 24 9.15e-01 -1.26e-02 9.51e-01
Uptake and actions of bacterial toxins 26 9.14e-01 1.23e-02 9.50e-01
Protein localization 156 7.99e-01 1.18e-02 8.65e-01
RNA Polymerase I Promoter Escape 42 8.96e-01 -1.17e-02 9.38e-01
Metabolism of steroids 123 8.27e-01 -1.14e-02 8.84e-01
PI-3K cascade:FGFR4 12 9.46e-01 -1.13e-02 9.71e-01
Membrane binding and targetting of GAG proteins 14 9.42e-01 -1.13e-02 9.68e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 9.42e-01 -1.13e-02 9.68e-01
Anti-inflammatory response favouring Leishmania parasite infection 79 8.63e-01 -1.12e-02 9.13e-01
Leishmania parasite growth and survival 79 8.63e-01 -1.12e-02 9.13e-01
Signaling by FGFR2 61 8.85e-01 1.07e-02 9.29e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 8.05e-01 1.07e-02 8.68e-01
Beta-catenin independent WNT signaling 138 8.29e-01 1.06e-02 8.86e-01
Inactivation, recovery and regulation of the phototransduction cascade 21 9.33e-01 1.06e-02 9.62e-01
PIWI-interacting RNA (piRNA) biogenesis 21 9.35e-01 -1.03e-02 9.62e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 9.24e-01 -1.01e-02 9.57e-01
Platelet calcium homeostasis 23 9.34e-01 1.00e-02 9.62e-01
GPCR downstream signalling 400 7.39e-01 9.73e-03 8.18e-01
NRIF signals cell death from the nucleus 16 9.47e-01 9.67e-03 9.71e-01
G alpha (i) signalling events 199 8.18e-01 9.45e-03 8.80e-01
Hedgehog ‘on’ state 83 8.95e-01 8.37e-03 9.38e-01
Interleukin-4 and Interleukin-13 signaling 97 8.87e-01 8.36e-03 9.30e-01
Deactivation of the beta-catenin transactivating complex 39 9.28e-01 -8.31e-03 9.59e-01
Retrograde neurotrophin signalling 14 9.58e-01 -8.09e-03 9.80e-01
ADP signalling through P2Y purinoceptor 12 17 9.54e-01 -8.08e-03 9.78e-01
RHO GTPases activate KTN1 11 9.65e-01 7.64e-03 9.84e-01
Metabolism 1798 6.13e-01 -7.25e-03 7.26e-01
rRNA processing in the nucleus and cytosol 190 8.64e-01 7.19e-03 9.13e-01
Constitutive Signaling by Aberrant PI3K in Cancer 63 9.25e-01 -6.88e-03 9.57e-01
Extra-nuclear estrogen signaling 68 9.23e-01 -6.78e-03 9.57e-01
The phototransduction cascade 22 9.56e-01 6.72e-03 9.79e-01
Nuclear signaling by ERBB4 30 9.50e-01 -6.67e-03 9.74e-01
Assembly Of The HIV Virion 16 9.65e-01 -6.33e-03 9.84e-01
Bile acid and bile salt metabolism 30 9.56e-01 -5.88e-03 9.78e-01
Basigin interactions 23 9.64e-01 5.38e-03 9.84e-01
Cell-extracellular matrix interactions 18 9.71e-01 4.89e-03 9.87e-01
FRS-mediated FGFR4 signaling 14 9.77e-01 4.48e-03 9.90e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 9.71e-01 4.40e-03 9.87e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 188 9.18e-01 -4.38e-03 9.53e-01
ROS and RNS production in phagocytes 33 9.67e-01 -4.22e-03 9.85e-01
rRNA processing 200 9.27e-01 -3.79e-03 9.58e-01
Sphingolipid de novo biosynthesis 40 9.67e-01 3.75e-03 9.85e-01
Cell death signalling via NRAGE, NRIF and NADE 73 9.60e-01 3.41e-03 9.81e-01
Nuclear Receptor transcription pathway 40 9.73e-01 3.09e-03 9.88e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 9.84e-01 3.00e-03 9.95e-01
Intra-Golgi traffic 41 9.74e-01 -2.98e-03 9.88e-01
Signal amplification 28 9.80e-01 2.81e-03 9.91e-01
Ca-dependent events 34 9.78e-01 -2.68e-03 9.91e-01
MECP2 regulates neuronal receptors and channels 17 9.86e-01 -2.49e-03 9.95e-01
Signaling by NOTCH2 32 9.81e-01 2.48e-03 9.92e-01
Vitamin D (calciferol) metabolism 10 9.89e-01 -2.46e-03 9.95e-01
Activation of RAC1 12 9.89e-01 2.37e-03 9.95e-01
Metabolism of folate and pterines 17 9.87e-01 -2.29e-03 9.95e-01
Hedgehog ‘off’ state 105 9.69e-01 2.22e-03 9.86e-01
Signaling by TGFB family members 114 9.69e-01 -2.10e-03 9.86e-01
Tryptophan catabolism 11 9.91e-01 -2.05e-03 9.95e-01
Hyaluronan uptake and degradation 12 9.92e-01 1.76e-03 9.95e-01
CaM pathway 32 9.88e-01 1.58e-03 9.95e-01
Calmodulin induced events 32 9.88e-01 1.58e-03 9.95e-01
Activation of AMPK downstream of NMDARs 20 9.91e-01 -1.41e-03 9.95e-01
Aspirin ADME 15 9.93e-01 -1.31e-03 9.96e-01
EPHB-mediated forward signaling 42 9.90e-01 -1.17e-03 9.95e-01
VEGFA-VEGFR2 Pathway 96 9.92e-01 -6.27e-04 9.95e-01
Signaling by FGFR4 33 9.96e-01 -5.32e-04 9.97e-01
Maturation of spike protein 9694548 37 9.96e-01 -5.01e-04 9.97e-01
G beta:gamma signalling through BTK 14 9.98e-01 -3.89e-04 9.99e-01
Gastrulation 87 1.00e+00 7.54e-06 1.00e+00


Detailed Gene set reports



Unwinding of DNA
set Unwinding of DNA
setSize 12
pANOVA 1.11e-05
s.dist -0.732
p.adjustANOVA 8.19e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCM8 -8818
MCM4 -8591
MCM7 -8302
MCM3 -8265
MCM5 -8036
MCM6 -7734
MCM2 -7451
CDC45 -7020
GINS1 -6334
GINS2 -5750
GINS4 -5419
GINS3 -456

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM8 -8818
MCM4 -8591
MCM7 -8302
MCM3 -8265
MCM5 -8036
MCM6 -7734
MCM2 -7451
CDC45 -7020
GINS1 -6334
GINS2 -5750
GINS4 -5419
GINS3 -456


Heme biosynthesis
set Heme biosynthesis
setSize 13
pANOVA 5.94e-06
s.dist -0.725
p.adjustANOVA 4.8e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
ABCG2 -9085
ALAD -9028
CPOX -8985
PPOX -8500
COX15 -8243
FECH -8227
UROD -8096
HMBS -7862
ALAS2 -7585
UROS -7444
ALAS1 -6293
FLVCR1 -6035
COX10 7222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCG2 -9085
ALAD -9028
CPOX -8985
PPOX -8500
COX15 -8243
FECH -8227
UROD -8096
HMBS -7862
ALAS2 -7585
UROS -7444
ALAS1 -6293
FLVCR1 -6035
COX10 7222


Polo-like kinase mediated events
set Polo-like kinase mediated events
setSize 16
pANOVA 6.09e-07
s.dist -0.72
p.adjustANOVA 6.65e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
PLK1 -8449
CENPF -8334
PKMYT1 -8319
WEE1 -8303
MYBL2 -8182
CDC25A -8033
CCNB1 -7895
EP300 -7800
LIN54 -7664
RBBP4 -7274
CCNB2 -7039
LIN52 -6595
FOXM1 -5822
CDC25C -5701
LIN9 -4737
LIN37 2416

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PLK1 -8449
CENPF -8334
PKMYT1 -8319
WEE1 -8303
MYBL2 -8182
CDC25A -8033
CCNB1 -7895
EP300 -7800
LIN54 -7664
RBBP4 -7274
CCNB2 -7039
LIN52 -6595
FOXM1 -5822
CDC25C -5701
LIN9 -4737
LIN37 2416


Activation of the pre-replicative complex
set Activation of the pre-replicative complex
setSize 32
pANOVA 2.2e-12
s.dist -0.717
p.adjustANOVA 6.08e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
ORC2 -9261
MCM10 -9073
MCM8 -8818
ORC3 -8758
MCM4 -8591
POLA2 -8530
RPA1 -8521
CDC6 -8471
RPA2 -8467
DBF4 -8304
MCM7 -8302
GMNN -8278
MCM3 -8265
MCM5 -8036
POLE -7874
CDC7 -7865
ORC1 -7783
MCM6 -7734
RPA3 -7490
MCM2 -7451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC2 -9261
MCM10 -9073
MCM8 -8818
ORC3 -8758
MCM4 -8591
POLA2 -8530
RPA1 -8521
CDC6 -8471
RPA2 -8467
DBF4 -8304
MCM7 -8302
GMNN -8278
MCM3 -8265
MCM5 -8036
POLE -7874
CDC7 -7865
ORC1 -7783
MCM6 -7734
RPA3 -7490
MCM2 -7451
CDK2 -7191
CDC45 -7020
CDT1 -6990
ORC4 -6114
PRIM1 -5482
POLA1 -5380
POLE3 -5229
POLE2 -4213
PRIM2 -3040
POLE4 -1273
ORC6 -866
ORC5 4360


Establishment of Sister Chromatid Cohesion
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 4.12e-05
s.dist -0.714
p.adjustANOVA 0.000262


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD21 -8927
CDCA5 -8894
ESCO2 -8729
ESCO1 -8416
PDS5A -8281
SMC1A -7766
SMC3 -7624
STAG2 -7516
WAPL -6327
STAG1 -3320
PDS5B 2342

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All member genes
GeneID Gene Rank
RAD21 -8927
CDCA5 -8894
ESCO2 -8729
ESCO1 -8416
PDS5A -8281
SMC1A -7766
SMC3 -7624
STAG2 -7516
WAPL -6327
STAG1 -3320
PDS5B 2342


G0 and Early G1
set G0 and Early G1
setSize 27
pANOVA 3.16e-10
s.dist -0.699
p.adjustANOVA 6.23e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBL2 -9235
CCNE1 -8588
CCNA2 -8517
CDC6 -8471
MYC -8408
TFDP2 -8294
CDK1 -8183
MYBL2 -8182
TFDP1 -8167
E2F1 -8108
PCNA -8082
CDC25A -8033
CCNE2 -7844
TOP2A -7760
LIN54 -7664
DYRK1A -7529
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274

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All member genes
GeneID Gene Rank
RBL2 -9235
CCNE1 -8588
CCNA2 -8517
CDC6 -8471
MYC -8408
TFDP2 -8294
CDK1 -8183
MYBL2 -8182
TFDP1 -8167
E2F1 -8108
PCNA -8082
CDC25A -8033
CCNE2 -7844
TOP2A -7760
LIN54 -7664
DYRK1A -7529
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
CDK2 -7191
LIN52 -6595
MAX -6237
LIN9 -4737
CCNA1 867
LIN37 2416
E2F5 5456


Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
set Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize 11
pANOVA 6.71e-05
s.dist -0.694
p.adjustANOVA 0.000408


Top enriched genes
Top 20 genes
GeneID Gene Rank
IRS2 -9266
GAB1 -9164
PIK3CB -8626
EPOR -7869
PIK3CG -7602
PIK3CD -6596
LYN -5977
PIK3R5 -5821
JAK2 -5808
PIK3R1 -4850
PIK3CA 130

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All member genes
GeneID Gene Rank
IRS2 -9266
GAB1 -9164
PIK3CB -8626
EPOR -7869
PIK3CG -7602
PIK3CD -6596
LYN -5977
PIK3R5 -5821
JAK2 -5808
PIK3R1 -4850
PIK3CA 130


Crosslinking of collagen fibrils
set Crosslinking of collagen fibrils
setSize 17
pANOVA 9.9e-07
s.dist 0.685
p.adjustANOVA 1e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
PCOLCE 8828
BMP1 8818
LOXL4 8716
COL1A1 8703
COL1A2 8508
LOXL2 8007
LOX 7873
COL4A2 7372
PXDN 6273
TLL1 6220
LOXL1 6194
COL4A1 6157
TLL2 5849
LOXL3 4226
COL4A5 3044
COL4A3 1693
COL4A4 -1524

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All member genes
GeneID Gene Rank
PCOLCE 8828
BMP1 8818
LOXL4 8716
COL1A1 8703
COL1A2 8508
LOXL2 8007
LOX 7873
COL4A2 7372
PXDN 6273
TLL1 6220
LOXL1 6194
COL4A1 6157
TLL2 5849
LOXL3 4226
COL4A5 3044
COL4A3 1693
COL4A4 -1524


Transcription of E2F targets under negative control by DREAM complex
set Transcription of E2F targets under negative control by DREAM complex
setSize 19
pANOVA 2.6e-07
s.dist -0.682
p.adjustANOVA 3.19e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBL2 -9235
CDC6 -8471
MYC -8408
TFDP2 -8294
TFDP1 -8167
E2F1 -8108
PCNA -8082
CDC25A -8033
TOP2A -7760
LIN54 -7664
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
LIN52 -6595
MAX -6237
LIN9 -4737
LIN37 2416
E2F5 5456

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBL2 -9235
CDC6 -8471
MYC -8408
TFDP2 -8294
TFDP1 -8167
E2F1 -8108
PCNA -8082
CDC25A -8033
TOP2A -7760
LIN54 -7664
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
LIN52 -6595
MAX -6237
LIN9 -4737
LIN37 2416
E2F5 5456


Collagen biosynthesis and modifying enzymes
set Collagen biosynthesis and modifying enzymes
setSize 63
pANOVA 7.96e-21
s.dist 0.681
p.adjustANOVA 7.44e-19


Top enriched genes
Top 20 genes
GeneID Gene Rank
P3H3 9026
COL11A2 9020
COL9A1 8997
PLOD1 8954
P4HA2 8939
COL5A1 8929
ADAMTS14 8920
COLGALT2 8901
PCOLCE 8828
BMP1 8818
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
COL1A1 8703
P3H1 8675
COL22A1 8670
COL9A3 8641
SERPINH1 8596
COL6A1 8514

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
P3H3 9026
COL11A2 9020
COL9A1 8997
PLOD1 8954
P4HA2 8939
COL5A1 8929
ADAMTS14 8920
COLGALT2 8901
PCOLCE 8828
BMP1 8818
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
COL1A1 8703
P3H1 8675
COL22A1 8670
COL9A3 8641
SERPINH1 8596
COL6A1 8514
COL1A2 8508
P4HA3 8493
ADAMTS2 8464
COL16A1 8389
COL3A1 8385
COL6A3 8285
COL10A1 8275
COL5A2 8240
P4HA1 8054
PCOLCE2 8030
COL19A1 7967
PLOD2 7849
COL7A1 7758
PPIB 7670
CRTAP 7624
COL4A2 7372
P3H2 7314
PLOD3 6730
COL18A1 6368
TLL1 6220
COL4A1 6157
COL13A1 5975
COL24A1 5879
TLL2 5849
COL8A2 4861
COL9A2 4828
COL2A1 4682
COL5A3 4383
COL12A1 4333
COL14A1 4177
COL26A1 4030
COL8A1 3274
COL4A5 3044
COL28A1 2533
COL21A1 2237
COLGALT1 1922
COL4A3 1693
P4HB 500
COL25A1 -432
COL4A4 -1524
COL17A1 -3867
ADAMTS3 -4189
COL23A1 -6846


Mitotic Telophase/Cytokinesis
set Mitotic Telophase/Cytokinesis
setSize 13
pANOVA 2.3e-05
s.dist -0.678
p.adjustANOVA 0.000153


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD21 -8927
PLK1 -8449
PDS5A -8281
KIF20A -7870
SMC1A -7766
KIF23 -7751
SMC3 -7624
STAG2 -7516
NIPBL -7235
WAPL -6327
MAU2 -3806
STAG1 -3320
PDS5B 2342

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All member genes
GeneID Gene Rank
RAD21 -8927
PLK1 -8449
PDS5A -8281
KIF20A -7870
SMC1A -7766
KIF23 -7751
SMC3 -7624
STAG2 -7516
NIPBL -7235
WAPL -6327
MAU2 -3806
STAG1 -3320
PDS5B 2342


Diseases associated with glycosaminoglycan metabolism
set Diseases associated with glycosaminoglycan metabolism
setSize 36
pANOVA 4.15e-12
s.dist 0.667
p.adjustANOVA 1.09e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACAN 9066
CHST6 9036
PRELP 9017
BGN 9016
FMOD 9007
PAPSS2 8952
OGN 8810
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
LUM 8170
GPC6 8104
HSPG2 8060
SDC4 8020
CHST3 8012
B4GALT7 7492
OMD 7237
EXT1 7099
CHST14 6519

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All member genes
GeneID Gene Rank
ACAN 9066
CHST6 9036
PRELP 9017
BGN 9016
FMOD 9007
PAPSS2 8952
OGN 8810
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
LUM 8170
GPC6 8104
HSPG2 8060
SDC4 8020
CHST3 8012
B4GALT7 7492
OMD 7237
EXT1 7099
CHST14 6519
EXT2 6355
HEXB 6349
SLC26A2 5760
B3GALT6 5595
AGRN 5283
B3GAT3 5155
B4GALT1 4369
HEXA 3215
GPC4 3129
ST3GAL3 3076
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985
CHSY1 -2550


Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
set Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
setSize 16
pANOVA 4.51e-06
s.dist -0.662
p.adjustANOVA 3.72e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBL2 -9235
CCNA2 -8517
TFDP2 -8294
CDK1 -8183
MYBL2 -8182
TFDP1 -8167
E2F1 -8108
LIN54 -7664
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
LIN52 -6595
LIN9 -4737
LIN37 2416
E2F5 5456

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBL2 -9235
CCNA2 -8517
TFDP2 -8294
CDK1 -8183
MYBL2 -8182
TFDP1 -8167
E2F1 -8108
LIN54 -7664
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
LIN52 -6595
LIN9 -4737
LIN37 2416
E2F5 5456


G1/S-Specific Transcription
set G1/S-Specific Transcription
setSize 29
pANOVA 1.05e-09
s.dist -0.654
p.adjustANOVA 1.88e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
RBL2 -9235
FBXO5 -8650
CCNE1 -8588
CDC6 -8471
TFDP2 -8294
CDK1 -8183
TFDP1 -8167
E2F1 -8108
PCNA -8082
CDC25A -8033
DHFR -8017
RRM2 -7815
ORC1 -7783
LIN54 -7664
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
TYMS -7141
CDC45 -7020

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBL2 -9235
FBXO5 -8650
CCNE1 -8588
CDC6 -8471
TFDP2 -8294
CDK1 -8183
TFDP1 -8167
E2F1 -8108
PCNA -8082
CDC25A -8033
DHFR -8017
RRM2 -7815
ORC1 -7783
LIN54 -7664
RBL1 -7400
E2F4 -7385
HDAC1 -7346
RBBP4 -7274
TYMS -7141
CDC45 -7020
CDT1 -6990
LIN52 -6595
TK1 -6148
POLA1 -5380
LIN9 -4737
CCNA1 867
E2F6 2150
LIN37 2416
E2F5 5456


Condensation of Prometaphase Chromosomes
set Condensation of Prometaphase Chromosomes
setSize 11
pANOVA 0.000172
s.dist -0.654
p.adjustANOVA 0.000948


Top enriched genes
Top 20 genes
GeneID Gene Rank
NCAPG -8280
SMC2 -8246
CDK1 -8183
NCAPD2 -8097
CCNB1 -7895
SMC4 -7842
CCNB2 -7039
NCAPH -6888
CSNK2A1 -4442
CSNK2A2 -2360
CSNK2B 1849

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All member genes
GeneID Gene Rank
NCAPG -8280
SMC2 -8246
CDK1 -8183
NCAPD2 -8097
CCNB1 -7895
SMC4 -7842
CCNB2 -7039
NCAPH -6888
CSNK2A1 -4442
CSNK2A2 -2360
CSNK2B 1849


DNA strand elongation
set DNA strand elongation
setSize 32
pANOVA 2.12e-10
s.dist -0.649
p.adjustANOVA 4.49e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
MCM8 -8818
LIG1 -8692
RFC3 -8636
MCM4 -8591
POLA2 -8530
RPA1 -8521
RPA2 -8467
MCM7 -8302
MCM3 -8265
FEN1 -8162
PCNA -8082
MCM5 -8036
RFC4 -8034
MCM6 -7734
RPA3 -7490
MCM2 -7451
RFC5 -7167
CDC45 -7020
GINS1 -6334
POLD3 -6279

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All member genes
GeneID Gene Rank
MCM8 -8818
LIG1 -8692
RFC3 -8636
MCM4 -8591
POLA2 -8530
RPA1 -8521
RPA2 -8467
MCM7 -8302
MCM3 -8265
FEN1 -8162
PCNA -8082
MCM5 -8036
RFC4 -8034
MCM6 -7734
RPA3 -7490
MCM2 -7451
RFC5 -7167
CDC45 -7020
GINS1 -6334
POLD3 -6279
POLD1 -6088
GINS2 -5750
PRIM1 -5482
GINS4 -5419
POLA1 -5380
DNA2 -5230
RFC2 -3507
PRIM2 -3040
RFC1 -2833
GINS3 -456
POLD4 2484
POLD2 5042


MET activates PTK2 signaling
set MET activates PTK2 signaling
setSize 29
pANOVA 1.71e-09
s.dist 0.646
p.adjustANOVA 2.9e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL11A2 9020
COL5A1 8929
FN1 8917
COL27A1 8756
COL11A1 8736
COL1A1 8703
COL1A2 8508
LAMC3 8406
COL3A1 8385
LAMB2 8272
COL5A2 8240
LAMA2 8071
MET 7389
ITGA3 6856
SRC 6430
LAMA5 5988
COL24A1 5879
LAMA1 5343
LAMC1 5108
COL2A1 4682

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All member genes
GeneID Gene Rank
COL11A2 9020
COL5A1 8929
FN1 8917
COL27A1 8756
COL11A1 8736
COL1A1 8703
COL1A2 8508
LAMC3 8406
COL3A1 8385
LAMB2 8272
COL5A2 8240
LAMA2 8071
MET 7389
ITGA3 6856
SRC 6430
LAMA5 5988
COL24A1 5879
LAMA1 5343
LAMC1 5108
COL2A1 4682
LAMB3 4577
COL5A3 4383
PTK2 3714
LAMB1 3496
ITGA2 3347
ITGB1 2392
LAMA4 2104
LAMA3 1768
HGF -7956


Condensation of Prophase Chromosomes
set Condensation of Prophase Chromosomes
setSize 24
pANOVA 5.34e-08
s.dist -0.641
p.adjustANOVA 7.38e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
H2AC20 -9074
NCAPG2 -8731
H2BC15 -8478
PLK1 -8449
KMT5A -8447
SMC2 -8246
NCAPD3 -8228
CDK1 -8183
CCNB1 -7895
SMC4 -7842
H2BC4 -7685
H2AZ2 -7314
PHF8 -6740
RB1 -6729
H2AJ -6155
H2BC11 -5985
H2AC18 -5975
NCAPH2 -5537
SET -4073
H2AC6 -3326

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All member genes
GeneID Gene Rank
H2AC20 -9074
NCAPG2 -8731
H2BC15 -8478
PLK1 -8449
KMT5A -8447
SMC2 -8246
NCAPD3 -8228
CDK1 -8183
CCNB1 -7895
SMC4 -7842
H2BC4 -7685
H2AZ2 -7314
PHF8 -6740
RB1 -6729
H2AJ -6155
H2BC11 -5985
H2AC18 -5975
NCAPH2 -5537
SET -4073
H2AC6 -3326
H2BC5 -1176
H2BC12 -500
H2BC21 61
MCPH1 547


Activation of ATR in response to replication stress
set Activation of ATR in response to replication stress
setSize 37
pANOVA 1.87e-11
s.dist -0.638
p.adjustANOVA 4.5e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
ORC2 -9261
MCM10 -9073
MCM8 -8818
ORC3 -8758
RFC3 -8636
MCM4 -8591
RPA1 -8521
CDC6 -8471
RPA2 -8467
DBF4 -8304
MCM7 -8302
MCM3 -8265
MCM5 -8036
RFC4 -8034
CDC25A -8033
CDC7 -7865
CHEK1 -7802
ORC1 -7783
MCM6 -7734
RAD17 -7632

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC2 -9261
MCM10 -9073
MCM8 -8818
ORC3 -8758
RFC3 -8636
MCM4 -8591
RPA1 -8521
CDC6 -8471
RPA2 -8467
DBF4 -8304
MCM7 -8302
MCM3 -8265
MCM5 -8036
RFC4 -8034
CDC25A -8033
CDC7 -7865
CHEK1 -7802
ORC1 -7783
MCM6 -7734
RAD17 -7632
RPA3 -7490
MCM2 -7451
CDK2 -7191
RFC5 -7167
CDC45 -7020
ORC4 -6114
CDC25C -5701
CLSPN -4782
RFC2 -3507
HUS1 -2318
RAD9A -1788
ATRIP -1005
ORC6 -866
ATR -463
RAD1 -130
RAD9B 4122
ORC5 4360


CS/DS degradation
set CS/DS degradation
setSize 11
pANOVA 0.000256
s.dist 0.637
p.adjustANOVA 0.00135


Top enriched genes
Top 20 genes
GeneID Gene Rank
BGN 9016
DCN 8666
CSPG4 8390
HYAL1 8189
IDS 6645
IDUA 6626
ARSB 6581
HEXB 6349
HEXA 3215
VCAN 649
HYAL3 -1317

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 9016
DCN 8666
CSPG4 8390
HYAL1 8189
IDS 6645
IDUA 6626
ARSB 6581
HEXB 6349
HEXA 3215
VCAN 649
HYAL3 -1317


Collagen formation
set Collagen formation
setSize 83
pANOVA 1.31e-23
s.dist 0.635
p.adjustANOVA 2.17e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
P3H3 9026
COL11A2 9020
COL9A1 8997
PLOD1 8954
P4HA2 8939
COL5A1 8929
ADAMTS14 8920
COLGALT2 8901
PCOLCE 8828
BMP1 8818
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
LOXL4 8716
COL1A1 8703
P3H1 8675
COL22A1 8670
COL9A3 8641
SERPINH1 8596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
P3H3 9026
COL11A2 9020
COL9A1 8997
PLOD1 8954
P4HA2 8939
COL5A1 8929
ADAMTS14 8920
COLGALT2 8901
PCOLCE 8828
BMP1 8818
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
LOXL4 8716
COL1A1 8703
P3H1 8675
COL22A1 8670
COL9A3 8641
SERPINH1 8596
COL6A1 8514
COL1A2 8508
P4HA3 8493
ADAMTS2 8464
MMP3 8436
COL16A1 8389
COL3A1 8385
COL6A3 8285
COL10A1 8275
COL5A2 8240
P4HA1 8054
PCOLCE2 8030
LOXL2 8007
COL19A1 7967
MMP13 7897
LOX 7873
PLOD2 7849
COL7A1 7758
PPIB 7670
CRTAP 7624
COL4A2 7372
P3H2 7314
DST 7277
ITGB4 7200
PLOD3 6730
COL18A1 6368
MMP9 6312
PXDN 6273
TLL1 6220
LOXL1 6194
COL4A1 6157
COL13A1 5975
CTSB 5947
COL24A1 5879
TLL2 5849
PLEC 5004
COL8A2 4861
COL9A2 4828
COL2A1 4682
LAMB3 4577
COL5A3 4383
COL12A1 4333
LOXL3 4226
COL14A1 4177
COL26A1 4030
CD151 3966
COL8A1 3274
COL4A5 3044
COL28A1 2533
COL21A1 2237
COLGALT1 1922
LAMA3 1768
COL4A3 1693
P4HB 500
CTSL -335
COL25A1 -432
COL4A4 -1524
CTSV -1578
COL17A1 -3867
ITGA6 -3926
ADAMTS3 -4189
COL23A1 -6846
CTSS -6892


Scavenging by Class A Receptors
set Scavenging by Class A Receptors
setSize 16
pANOVA 1.25e-05
s.dist 0.631
p.adjustANOVA 9.01e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL1A1 8703
COL1A2 8508
MASP1 8412
COL3A1 8385
COLEC12 7721
FTL 7381
COL4A2 7372
SCARA5 7336
COL4A1 6157
APOE 6061
FTH1 5335
HSP90B1 5304
MARCO 5285
MSR1 3995
CALR 1497
APOB -6686

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 8703
COL1A2 8508
MASP1 8412
COL3A1 8385
COLEC12 7721
FTL 7381
COL4A2 7372
SCARA5 7336
COL4A1 6157
APOE 6061
FTH1 5335
HSP90B1 5304
MARCO 5285
MSR1 3995
CALR 1497
APOB -6686


Collagen chain trimerization
set Collagen chain trimerization
setSize 40
pANOVA 6.42e-12
s.dist 0.627
p.adjustANOVA 1.66e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL11A2 9020
COL9A1 8997
COL5A1 8929
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
COL1A1 8703
COL22A1 8670
COL9A3 8641
COL6A1 8514
COL1A2 8508
COL16A1 8389
COL3A1 8385
COL6A3 8285
COL10A1 8275
COL5A2 8240
COL19A1 7967
COL7A1 7758
COL4A2 7372

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL11A2 9020
COL9A1 8997
COL5A1 8929
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
COL1A1 8703
COL22A1 8670
COL9A3 8641
COL6A1 8514
COL1A2 8508
COL16A1 8389
COL3A1 8385
COL6A3 8285
COL10A1 8275
COL5A2 8240
COL19A1 7967
COL7A1 7758
COL4A2 7372
COL18A1 6368
COL4A1 6157
COL13A1 5975
COL24A1 5879
COL8A2 4861
COL9A2 4828
COL2A1 4682
COL5A3 4383
COL12A1 4333
COL14A1 4177
COL26A1 4030
COL8A1 3274
COL4A5 3044
COL28A1 2533
COL21A1 2237
COL4A3 1693
COL25A1 -432
COL4A4 -1524
COL17A1 -3867
COL23A1 -6846


Assembly of collagen fibrils and other multimeric structures
set Assembly of collagen fibrils and other multimeric structures
setSize 55
pANOVA 8.2e-16
s.dist 0.627
p.adjustANOVA 3.83e-14


Top enriched genes
Top 20 genes
GeneID Gene Rank
COL11A2 9020
COL9A1 8997
COL5A1 8929
PCOLCE 8828
BMP1 8818
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
LOXL4 8716
COL1A1 8703
COL9A3 8641
COL6A1 8514
COL1A2 8508
MMP3 8436
COL3A1 8385
COL6A3 8285
COL10A1 8275
COL5A2 8240
LOXL2 8007

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL11A2 9020
COL9A1 8997
COL5A1 8929
PCOLCE 8828
BMP1 8818
COL27A1 8756
COL6A2 8745
COL11A1 8736
COL15A1 8719
LOXL4 8716
COL1A1 8703
COL9A3 8641
COL6A1 8514
COL1A2 8508
MMP3 8436
COL3A1 8385
COL6A3 8285
COL10A1 8275
COL5A2 8240
LOXL2 8007
MMP13 7897
LOX 7873
COL7A1 7758
COL4A2 7372
DST 7277
ITGB4 7200
COL18A1 6368
MMP9 6312
PXDN 6273
TLL1 6220
LOXL1 6194
COL4A1 6157
CTSB 5947
COL24A1 5879
TLL2 5849
PLEC 5004
COL8A2 4861
COL9A2 4828
COL2A1 4682
LAMB3 4577
COL5A3 4383
COL12A1 4333
LOXL3 4226
COL14A1 4177
CD151 3966
COL8A1 3274
COL4A5 3044
LAMA3 1768
COL4A3 1693
CTSL -335
COL4A4 -1524
CTSV -1578
COL17A1 -3867
ITGA6 -3926
CTSS -6892


Deposition of new CENPA-containing nucleosomes at the centromere
set Deposition of new CENPA-containing nucleosomes at the centromere
setSize 37
pANOVA 4.83e-11
s.dist -0.624
p.adjustANOVA 1.09e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
CENPH -9153
RBBP7 -9119
H2AC20 -9074
CENPQ -8680
CENPC -8633
CENPI -8574
H2BC15 -8478
CENPK -8437
MIS18A -7881
HJURP -7765
KNL1 -7756
H2BC4 -7685
CENPU -7534
SMARCA5 -7469
H2AZ2 -7314
RBBP4 -7274
MIS18BP1 -7221
CENPA -6936
CENPW -6660
CENPO -6578

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CENPH -9153
RBBP7 -9119
H2AC20 -9074
CENPQ -8680
CENPC -8633
CENPI -8574
H2BC15 -8478
CENPK -8437
MIS18A -7881
HJURP -7765
KNL1 -7756
H2BC4 -7685
CENPU -7534
SMARCA5 -7469
H2AZ2 -7314
RBBP4 -7274
MIS18BP1 -7221
CENPA -6936
CENPW -6660
CENPO -6578
H2AJ -6155
CENPL -5997
H2BC11 -5985
H2AC18 -5975
ITGB3BP -5851
CENPP -5386
CENPN -4658
OIP5 -4400
RUVBL1 -3654
H2AC6 -3326
CENPM -2520
CENPT -1620
H2BC5 -1176
RSF1 -1109
H2BC12 -500
H2BC21 61
NPM1 87


Nucleosome assembly
set Nucleosome assembly
setSize 37
pANOVA 4.83e-11
s.dist -0.624
p.adjustANOVA 1.09e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
CENPH -9153
RBBP7 -9119
H2AC20 -9074
CENPQ -8680
CENPC -8633
CENPI -8574
H2BC15 -8478
CENPK -8437
MIS18A -7881
HJURP -7765
KNL1 -7756
H2BC4 -7685
CENPU -7534
SMARCA5 -7469
H2AZ2 -7314
RBBP4 -7274
MIS18BP1 -7221
CENPA -6936
CENPW -6660
CENPO -6578

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CENPH -9153
RBBP7 -9119
H2AC20 -9074
CENPQ -8680
CENPC -8633
CENPI -8574
H2BC15 -8478
CENPK -8437
MIS18A -7881
HJURP -7765
KNL1 -7756
H2BC4 -7685
CENPU -7534
SMARCA5 -7469
H2AZ2 -7314
RBBP4 -7274
MIS18BP1 -7221
CENPA -6936
CENPW -6660
CENPO -6578
H2AJ -6155
CENPL -5997
H2BC11 -5985
H2AC18 -5975
ITGB3BP -5851
CENPP -5386
CENPN -4658
OIP5 -4400
RUVBL1 -3654
H2AC6 -3326
CENPM -2520
CENPT -1620
H2BC5 -1176
RSF1 -1109
H2BC12 -500
H2BC21 61
NPM1 87


Cohesin Loading onto Chromatin
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 0.000642
s.dist -0.623
p.adjustANOVA 0.00303


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD21 -8927
PDS5A -8281
SMC1A -7766
SMC3 -7624
STAG2 -7516
NIPBL -7235
WAPL -6327
MAU2 -3806
STAG1 -3320
PDS5B 2342

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD21 -8927
PDS5A -8281
SMC1A -7766
SMC3 -7624
STAG2 -7516
NIPBL -7235
WAPL -6327
MAU2 -3806
STAG1 -3320
PDS5B 2342


Elastic fibre formation
set Elastic fibre formation
setSize 40
pANOVA 1.37e-11
s.dist 0.618
p.adjustANOVA 3.41e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
LTBP3 8928
FN1 8917
ITGA5 8738
LOXL4 8716
BMP4 8404
ITGB8 8368
MFAP2 8349
EMILIN1 8103
BMP7 8088
LOXL2 8007
BMP2 7940
LOX 7873
GDF5 7855
EFEMP2 7837
ITGB5 7736
TGFB3 7710
FBLN2 7652
LTBP4 7648
FBLN5 7645
MFAP4 7152

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LTBP3 8928
FN1 8917
ITGA5 8738
LOXL4 8716
BMP4 8404
ITGB8 8368
MFAP2 8349
EMILIN1 8103
BMP7 8088
LOXL2 8007
BMP2 7940
LOX 7873
GDF5 7855
EFEMP2 7837
ITGB5 7736
TGFB3 7710
FBLN2 7652
LTBP4 7648
FBLN5 7645
MFAP4 7152
ELN 6961
FBLN1 6639
EFEMP1 6424
LOXL1 6194
EMILIN2 6067
EMILIN3 5887
TGFB2 5832
MFAP3 5782
TGFB1 4849
LTBP2 4676
LOXL3 4226
LTBP1 4121
ITGAV 3268
MFAP5 2885
ITGB1 2392
FBN1 216
FURIN -586
ITGB3 -3878
ITGA8 -5741
FBN2 -6123


A tetrasaccharide linker sequence is required for GAG synthesis
set A tetrasaccharide linker sequence is required for GAG synthesis
setSize 22
pANOVA 6.72e-07
s.dist 0.612
p.adjustANOVA 7.12e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
XYLT2 7663
B4GALT7 7492
B3GAT1 6955
XYLT1 6365
B3GALT6 5595
AGRN 5283
B3GAT3 5155
GPC4 3129
GPC2 2497
SDC1 2273
B3GAT2 1409
VCAN 649

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
XYLT2 7663
B4GALT7 7492
B3GAT1 6955
XYLT1 6365
B3GALT6 5595
AGRN 5283
B3GAT3 5155
GPC4 3129
GPC2 2497
SDC1 2273
B3GAT2 1409
VCAN 649
SDC3 194
GPC3 -985


Defective B4GALT7 causes EDS, progeroid type
set Defective B4GALT7 causes EDS, progeroid type
setSize 16
pANOVA 2.35e-05
s.dist 0.611
p.adjustANOVA 0.000155


Top enriched genes
Top 20 genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
B4GALT7 7492
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
B4GALT7 7492
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985


ECM proteoglycans
set ECM proteoglycans
setSize 66
pANOVA 9.28e-18
s.dist 0.61
p.adjustANOVA 5.79e-16


Top enriched genes
Top 20 genes
GeneID Gene Rank
ACAN 9066
HAPLN1 9034
BGN 9016
FMOD 9007
COL9A1 8997
COMP 8975
COL5A1 8929
FN1 8917
MATN4 8839
COL6A2 8745
COL1A1 8703
DCN 8666
COL9A3 8641
COL6A1 8514
COL1A2 8508
COL3A1 8385
COL6A3 8285
LAMB2 8272
SPARC 8252
COL5A2 8240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN 9066
HAPLN1 9034
BGN 9016
FMOD 9007
COL9A1 8997
COMP 8975
COL5A1 8929
FN1 8917
MATN4 8839
COL6A2 8745
COL1A1 8703
DCN 8666
COL9A3 8641
COL6A1 8514
COL1A2 8508
COL3A1 8385
COL6A3 8285
LAMB2 8272
SPARC 8252
COL5A2 8240
LUM 8170
LAMA2 8071
HSPG2 8060
TNC 8052
IBSP 7845
LRP4 7839
TNN 7781
MATN3 7754
ITGB5 7736
TGFB3 7710
TNXB 7595
TNR 7528
COL4A2 7372
SERPINE1 6921
APP 6891
ASPN 6641
DAG1 6286
PTPRS 6221
COL4A1 6157
LAMA5 5988
TGFB2 5832
LAMA1 5343
AGRN 5283
LAMC1 5108
TGFB1 4849
COL9A2 4828
COL2A1 4682
DMP1 4643
COL5A3 4383
LAMB1 3496
ITGA2 3347
ITGAV 3268
COL4A5 3044
ITGB1 2392
LAMA4 2104
NCAM1 1876
LAMA3 1768
COL4A3 1693
VCAN 649
ITGA7 9
COL4A4 -1524
ITGA9 -2331
ITGB3 -3878
ITGAX -5680
ITGA8 -5741
ITGA2B -8973


Impaired BRCA2 binding to PALB2
set Impaired BRCA2 binding to PALB2
setSize 24
pANOVA 2.62e-07
s.dist -0.607
p.adjustANOVA 3.19e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357
RAD51D -2643
TOP3A -944
RAD50 -567
RAD51B 178


Molecules associated with elastic fibres
set Molecules associated with elastic fibres
setSize 33
pANOVA 2.02e-09
s.dist 0.603
p.adjustANOVA 3.29e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
LTBP3 8928
FN1 8917
BMP4 8404
ITGB8 8368
MFAP2 8349
EMILIN1 8103
BMP7 8088
BMP2 7940
GDF5 7855
EFEMP2 7837
ITGB5 7736
TGFB3 7710
FBLN2 7652
LTBP4 7648
FBLN5 7645
MFAP4 7152
ELN 6961
FBLN1 6639
EFEMP1 6424
EMILIN2 6067

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LTBP3 8928
FN1 8917
BMP4 8404
ITGB8 8368
MFAP2 8349
EMILIN1 8103
BMP7 8088
BMP2 7940
GDF5 7855
EFEMP2 7837
ITGB5 7736
TGFB3 7710
FBLN2 7652
LTBP4 7648
FBLN5 7645
MFAP4 7152
ELN 6961
FBLN1 6639
EFEMP1 6424
EMILIN2 6067
EMILIN3 5887
TGFB2 5832
MFAP3 5782
TGFB1 4849
LTBP2 4676
LTBP1 4121
ITGAV 3268
MFAP5 2885
ITGB1 2392
FBN1 216
ITGB3 -3878
ITGA8 -5741
FBN2 -6123


Defective B3GALT6 causes EDSP2 and SEMDJL1
set Defective B3GALT6 causes EDSP2 and SEMDJL1
setSize 16
pANOVA 3.48e-05
s.dist 0.598
p.adjustANOVA 0.000225


Top enriched genes
Top 20 genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
B3GALT6 5595
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
B3GALT6 5595
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985


HDR through MMEJ (alt-NHEJ)
set HDR through MMEJ (alt-NHEJ)
setSize 12
pANOVA 0.000339
s.dist -0.597
p.adjustANOVA 0.00172


Top enriched genes
Top 20 genes
GeneID Gene Rank
MRE11 -9086
PARP1 -8969
FEN1 -8162
BRCA2 -7996
NBN -7728
POLQ -7343
PARP2 -5082
RBBP8 -4705
LIG3 -4419
RAD52 -3148
RAD50 -567
XRCC1 -85

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRE11 -9086
PARP1 -8969
FEN1 -8162
BRCA2 -7996
NBN -7728
POLQ -7343
PARP2 -5082
RBBP8 -4705
LIG3 -4419
RAD52 -3148
RAD50 -567
XRCC1 -85


Lagging Strand Synthesis
set Lagging Strand Synthesis
setSize 20
pANOVA 3.73e-06
s.dist -0.597
p.adjustANOVA 3.19e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
LIG1 -8692
RFC3 -8636
POLA2 -8530
RPA1 -8521
RPA2 -8467
FEN1 -8162
PCNA -8082
RFC4 -8034
RPA3 -7490
RFC5 -7167
POLD3 -6279
POLD1 -6088
PRIM1 -5482
POLA1 -5380
DNA2 -5230
RFC2 -3507
PRIM2 -3040
RFC1 -2833
POLD4 2484
POLD2 5042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LIG1 -8692
RFC3 -8636
POLA2 -8530
RPA1 -8521
RPA2 -8467
FEN1 -8162
PCNA -8082
RFC4 -8034
RPA3 -7490
RFC5 -7167
POLD3 -6279
POLD1 -6088
PRIM1 -5482
POLA1 -5380
DNA2 -5230
RFC2 -3507
PRIM2 -3040
RFC1 -2833
POLD4 2484
POLD2 5042


Defective B3GAT3 causes JDSSDHD
set Defective B3GAT3 causes JDSSDHD
setSize 16
pANOVA 3.81e-05
s.dist 0.595
p.adjustANOVA 0.000244


Top enriched genes
Top 20 genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
AGRN 5283
B3GAT3 5155
GPC4 3129
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 9016
GPC1 8715
DCN 8666
CSPG4 8390
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
AGRN 5283
B3GAT3 5155
GPC4 3129
GPC2 2497
SDC1 2273
VCAN 649
SDC3 194
GPC3 -985


Anchoring fibril formation
set Anchoring fibril formation
setSize 13
pANOVA 0.000227
s.dist 0.59
p.adjustANOVA 0.00122


Top enriched genes
Top 20 genes
GeneID Gene Rank
BMP1 8818
COL1A1 8703
COL1A2 8508
COL7A1 7758
COL4A2 7372
TLL1 6220
COL4A1 6157
TLL2 5849
LAMB3 4577
COL4A5 3044
LAMA3 1768
COL4A3 1693
COL4A4 -1524

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BMP1 8818
COL1A1 8703
COL1A2 8508
COL7A1 7758
COL4A2 7372
TLL1 6220
COL4A1 6157
TLL2 5849
LAMB3 4577
COL4A5 3044
LAMA3 1768
COL4A3 1693
COL4A4 -1524


Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
set Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
setSize 14
pANOVA 0.000135
s.dist -0.589
p.adjustANOVA 0.00077


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH2 -8831
LIG1 -8692
RPA1 -8521
RPA2 -8467
EXO1 -8404
PCNA -8082
MSH6 -7992
RPA3 -7490
MLH1 -6348
POLD3 -6279
POLD1 -6088
PMS2 246
POLD4 2484
POLD2 5042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH2 -8831
LIG1 -8692
RPA1 -8521
RPA2 -8467
EXO1 -8404
PCNA -8082
MSH6 -7992
RPA3 -7490
MLH1 -6348
POLD3 -6279
POLD1 -6088
PMS2 246
POLD4 2484
POLD2 5042


FGFR2 ligand binding and activation
set FGFR2 ligand binding and activation
setSize 10
pANOVA 0.00143
s.dist 0.582
p.adjustANOVA 0.00605


Top enriched genes
Top 20 genes
GeneID Gene Rank
FGFBP2 9061
FGF10 8611
FGF18 8530
FGF2 7257
FGFR2 6765
FGF1 6288
FGFBP3 4927
FGF9 3380
FGF23 2412
FGF7 -4936

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGFBP2 9061
FGF10 8611
FGF18 8530
FGF2 7257
FGFR2 6765
FGF1 6288
FGFBP3 4927
FGF9 3380
FGF23 2412
FGF7 -4936


Processive synthesis on the lagging strand
set Processive synthesis on the lagging strand
setSize 15
pANOVA 9.61e-05
s.dist -0.582
p.adjustANOVA 0.000559


Top enriched genes
Top 20 genes
GeneID Gene Rank
LIG1 -8692
POLA2 -8530
RPA1 -8521
RPA2 -8467
FEN1 -8162
PCNA -8082
RPA3 -7490
POLD3 -6279
POLD1 -6088
PRIM1 -5482
POLA1 -5380
DNA2 -5230
PRIM2 -3040
POLD4 2484
POLD2 5042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LIG1 -8692
POLA2 -8530
RPA1 -8521
RPA2 -8467
FEN1 -8162
PCNA -8082
RPA3 -7490
POLD3 -6279
POLD1 -6088
PRIM1 -5482
POLA1 -5380
DNA2 -5230
PRIM2 -3040
POLD4 2484
POLD2 5042


Meiotic recombination
set Meiotic recombination
setSize 33
pANOVA 7.37e-09
s.dist -0.581
p.adjustANOVA 1.12e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH5 -9158
RAD51C -9102
MRE11 -9086
H2AC20 -9074
PSMC3IP -8632
RPA1 -8521
H2BC15 -8478
RPA2 -8467
BRCA1 -8196
BRCA2 -7996
RAD51 -7965
NBN -7728
H2BC4 -7685
RPA3 -7490
H2AZ2 -7314
CDK2 -7191
MLH1 -6348
H2AJ -6155
H2BC11 -5985
H2AC18 -5975

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH5 -9158
RAD51C -9102
MRE11 -9086
H2AC20 -9074
PSMC3IP -8632
RPA1 -8521
H2BC15 -8478
RPA2 -8467
BRCA1 -8196
BRCA2 -7996
RAD51 -7965
NBN -7728
H2BC4 -7685
RPA3 -7490
H2AZ2 -7314
CDK2 -7191
MLH1 -6348
H2AJ -6155
H2BC11 -5985
H2AC18 -5975
BLM -5460
MND1 -4771
RBBP8 -4705
ATM -4642
DMC1 -3530
H2AC6 -3326
H2BC5 -1176
TOP3A -944
RAD50 -567
H2BC12 -500
H2BC21 61
MLH3 2529
CDK4 3572


Defective EXT1 causes exostoses 1, TRPS2 and CHDS
set Defective EXT1 causes exostoses 1, TRPS2 and CHDS
setSize 13
pANOVA 0.000335
s.dist 0.575
p.adjustANOVA 0.0017


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPC1 8715
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
EXT1 7099
EXT2 6355
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
SDC3 194
GPC3 -985

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPC1 8715
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
EXT1 7099
EXT2 6355
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
SDC3 194
GPC3 -985


Defective EXT2 causes exostoses 2
set Defective EXT2 causes exostoses 2
setSize 13
pANOVA 0.000335
s.dist 0.575
p.adjustANOVA 0.0017


Top enriched genes
Top 20 genes
GeneID Gene Rank
GPC1 8715
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
EXT1 7099
EXT2 6355
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
SDC3 194
GPC3 -985

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GPC1 8715
SDC2 8295
GPC6 8104
HSPG2 8060
SDC4 8020
EXT1 7099
EXT2 6355
AGRN 5283
GPC4 3129
GPC2 2497
SDC1 2273
SDC3 194
GPC3 -985


Signaling by Erythropoietin
set Signaling by Erythropoietin
setSize 24
pANOVA 1.49e-06
s.dist -0.567
p.adjustANOVA 1.41e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
IRS2 -9266
STAT5A -9210
GAB1 -9164
STAT5B -9139
NRAS -8739
PIK3CB -8626
SOS1 -7948
EPOR -7869
PIK3CG -7602
PLCG2 -7553
PIK3CD -6596
VAV1 -6457
GRB2 -6418
KRAS -6227
LYN -5977
CRKL -5903
PIK3R5 -5821
JAK2 -5808
PIK3R1 -4850
RAPGEF1 -4596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 -9266
STAT5A -9210
GAB1 -9164
STAT5B -9139
NRAS -8739
PIK3CB -8626
SOS1 -7948
EPOR -7869
PIK3CG -7602
PLCG2 -7553
PIK3CD -6596
VAV1 -6457
GRB2 -6418
KRAS -6227
LYN -5977
CRKL -5903
PIK3R5 -5821
JAK2 -5808
PIK3R1 -4850
RAPGEF1 -4596
PIK3CA 130
SHC1 2191
PLCG1 6148
HRAS 7427


Mismatch Repair
set Mismatch Repair
setSize 15
pANOVA 0.000153
s.dist -0.565
p.adjustANOVA 0.000856


Top enriched genes
Top 20 genes
GeneID Gene Rank
MSH2 -8831
LIG1 -8692
RPA1 -8521
RPA2 -8467
EXO1 -8404
PCNA -8082
MSH6 -7992
RPA3 -7490
MLH1 -6348
POLD3 -6279
POLD1 -6088
MSH3 -2161
PMS2 246
POLD4 2484
POLD2 5042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MSH2 -8831
LIG1 -8692
RPA1 -8521
RPA2 -8467
EXO1 -8404
PCNA -8082
MSH6 -7992
RPA3 -7490
MLH1 -6348
POLD3 -6279
POLD1 -6088
MSH3 -2161
PMS2 246
POLD4 2484
POLD2 5042


Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
set Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
setSize 25
pANOVA 1.3e-06
s.dist -0.559
p.adjustANOVA 1.26e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357
RAD51D -2643
TOP3A -944
RAD50 -567
RAD51B 178
SEM1 5317


Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
set Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
setSize 25
pANOVA 1.3e-06
s.dist -0.559
p.adjustANOVA 1.26e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357
RAD51D -2643
TOP3A -944
RAD50 -567
RAD51B 178
SEM1 5317


Defective homologous recombination repair (HRR) due to BRCA1 loss of function
set Defective homologous recombination repair (HRR) due to BRCA1 loss of function
setSize 25
pANOVA 1.3e-06
s.dist -0.559
p.adjustANOVA 1.26e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357
RAD51D -2643
TOP3A -944
RAD50 -567
RAD51B 178
SEM1 5317


Defective homologous recombination repair (HRR) due to PALB2 loss of function
set Defective homologous recombination repair (HRR) due to PALB2 loss of function
setSize 25
pANOVA 1.3e-06
s.dist -0.559
p.adjustANOVA 1.26e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51C -9102
MRE11 -9086
EXO1 -8404
BRCA1 -8196
WRN -8105
RMI1 -8062
BRCA2 -7996
RAD51 -7965
NBN -7728
RAD51AP1 -7269
BRIP1 -6978
XRCC2 -6542
BLM -5460
DNA2 -5230
BARD1 -5207
RMI2 -4726
RBBP8 -4705
ATM -4642
KAT5 -3871
PALB2 -3357
RAD51D -2643
TOP3A -944
RAD50 -567
RAD51B 178
SEM1 5317


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.1 (2024-06-14)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.12.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.4.0               GGally_2.2.1               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.4.0           
##  [7] topconfects_1.20.0          limma_3.60.4               
##  [9] eulerr_7.0.2                mitch_1.16.0               
## [11] MASS_7.3-61                 fgsea_1.30.0               
## [13] gplots_3.1.3.1              DESeq2_1.44.0              
## [15] SummarizedExperiment_1.34.0 Biobase_2.64.0             
## [17] MatrixGenerics_1.16.0       matrixStats_1.4.1          
## [19] GenomicRanges_1.56.1        GenomeInfoDb_1.40.1        
## [21] IRanges_2.38.1              S4Vectors_0.42.1           
## [23] BiocGenerics_0.50.0         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.5                
## [31] tidyr_1.3.1                 tibble_3.2.1               
## [33] ggplot2_3.5.1               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.26.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-8            gridExtra_2.3           rlang_1.1.4            
##  [4] magrittr_2.0.3          compiler_4.4.1          systemfonts_1.1.0      
##  [7] vctrs_0.6.5             pkgconfig_2.0.3         crayon_1.5.3           
## [10] fastmap_1.2.0           XVector_0.44.0          caTools_1.18.3         
## [13] utf8_1.2.4              promises_1.3.0          rmarkdown_2.28         
## [16] tzdb_0.4.0              UCSC.utils_1.0.0        xfun_0.47              
## [19] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [22] highr_0.11              later_1.3.2             DelayedArray_0.30.1    
## [25] BiocParallel_1.38.0     parallel_4.4.1          R6_2.5.1               
## [28] bslib_0.8.0             stringi_1.8.4           RColorBrewer_1.1-3     
## [31] jquerylib_0.1.4         assertthat_0.2.1        Rcpp_1.0.13            
## [34] knitr_1.48              httpuv_1.6.15           Matrix_1.7-0           
## [37] timechange_0.3.0        tidyselect_1.2.1        rstudioapi_0.16.0      
## [40] abind_1.4-5             yaml_2.3.10             codetools_0.2-20       
## [43] lattice_0.22-6          plyr_1.8.9              shiny_1.9.1            
## [46] withr_3.0.1             evaluate_0.24.0         ggstats_0.6.0          
## [49] xml2_1.3.6              pillar_1.9.0            KernSmooth_2.23-24     
## [52] generics_0.1.3          hms_1.1.3               munsell_0.5.1          
## [55] scales_1.3.0            xtable_1.8-4            glue_1.7.0             
## [58] tools_4.4.1             data.table_1.16.0       locfit_1.5-9.10        
## [61] fastmatch_1.1-4         cowplot_1.1.3           grid_4.4.1             
## [64] colorspace_2.1-1        GenomeInfoDbData_1.2.12 cli_3.6.3              
## [67] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.4.1         
## [70] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [73] digest_0.6.37           SparseArray_1.4.8       htmlwidgets_1.6.4      
## [76] htmltools_0.5.8.1       lifecycle_1.0.4         httr_1.4.7             
## [79] statmod_1.5.0           mime_0.12

END of report