date generated: 2024-02-26

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
OAvRCA OAvRCR
5_8S_rRNA -1.1769575 -6.143587
7SK 0.3057012 -1.282326
A1BG -0.3509761 -4.436253
A1BG.AS1 -1.0241247 -1.588745
A2M 0.9618886 2.397394
A2M.AS1 2.2323813 2.213143

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 16539
duplicated_genes_present 0
num_profile_genes_in_sets 8293
num_profile_genes_not_in_sets 8246
profile_pearson_correl -0.00871
profile_spearman_correl -0.00901

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1143
num_genesets_included 1469

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 451

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pMANOVA p.adjustMANOVA s.dist s.OAvRCA s.OAvRCR p.OAvRCA p.OAvRCR
Peptide chain elongation 87 7.78e-50 2.35e-47 0.934 0.740 -0.570 6.05e-33 3.91e-20
SARS-CoV-1 modulates host translation machinery 36 5.10e-21 1.97e-19 0.934 0.761 -0.542 2.71e-15 1.83e-08
Eukaryotic Translation Elongation 92 2.53e-52 3.71e-49 0.931 0.731 -0.577 6.43e-34 1.11e-21
Viral mRNA Translation 87 4.69e-48 8.61e-46 0.917 0.725 -0.562 1.17e-31 1.27e-19
Formation of a pool of free 40S subunits 99 4.01e-51 2.33e-48 0.887 0.705 -0.538 5.90e-34 2.01e-20
Selenocysteine synthesis 91 2.61e-46 3.49e-44 0.880 0.707 -0.525 1.90e-31 4.65e-18
Eukaryotic Translation Termination 91 8.08e-46 9.89e-44 0.876 0.682 -0.549 2.03e-29 1.33e-19
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 3.46e-45 3.91e-43 0.860 0.673 -0.536 2.81e-29 4.21e-19
L13a-mediated translational silencing of Ceruloplasmin expression 109 4.75e-51 2.33e-48 0.845 0.664 -0.524 4.22e-33 3.29e-21
GTP hydrolysis and joining of the 60S ribosomal subunit 110 7.99e-50 2.35e-47 0.831 0.652 -0.516 3.00e-32 8.03e-21
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 9.95e-45 1.04e-42 0.830 0.652 -0.513 3.07e-29 1.12e-18
Formation of the ternary complex, and subsequently, the 43S complex 51 5.47e-23 2.51e-21 0.822 0.656 -0.495 4.84e-16 9.59e-10
Cap-dependent Translation Initiation 117 2.09e-48 4.38e-46 0.795 0.612 -0.507 2.63e-30 2.45e-21
Eukaryotic Translation Initiation 117 2.09e-48 4.38e-46 0.795 0.612 -0.507 2.63e-30 2.45e-21
SRP-dependent cotranslational protein targeting to membrane 110 2.40e-42 2.21e-40 0.766 0.553 -0.530 1.09e-23 7.90e-22
FCGR activation 19 5.24e-08 6.75e-07 0.765 -0.707 -0.290 9.31e-08 2.85e-02
Translation initiation complex formation 58 1.73e-22 7.71e-21 0.762 0.598 -0.472 3.09e-15 4.82e-10
Selenoamino acid metabolism 113 6.20e-43 6.07e-41 0.761 0.579 -0.494 1.90e-26 1.17e-19
Gluconeogenesis 27 6.66e-11 1.53e-09 0.757 -0.507 -0.563 5.09e-06 4.18e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.15e-22 9.27e-21 0.754 0.582 -0.480 9.88e-15 1.86e-10
Ribosomal scanning and start codon recognition 58 8.44e-22 3.54e-20 0.750 0.581 -0.475 1.94e-14 3.87e-10
Classical antibody-mediated complement activation 13 1.63e-05 1.09e-04 0.750 -0.713 -0.232 8.45e-06 1.48e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.16e-08 4.38e-07 0.743 0.355 -0.653 4.82e-03 2.21e-07
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 2.92e-05 1.86e-04 0.734 0.252 -0.689 1.15e-01 1.68e-05
SARS-CoV-2 modulates host translation machinery 49 1.95e-17 5.85e-16 0.727 0.608 -0.398 1.70e-13 1.47e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.45e-39 4.99e-37 0.724 0.561 -0.458 6.39e-25 4.17e-17
Nonsense-Mediated Decay (NMD) 113 6.45e-39 4.99e-37 0.724 0.561 -0.458 6.39e-25 4.17e-17
Expression and translocation of olfactory receptors 21 9.15e-08 1.08e-06 0.715 0.677 0.231 7.80e-08 6.63e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 1.07e-08 1.63e-07 0.703 0.375 -0.594 1.17e-03 2.70e-07
Scavenging of heme from plasma 13 1.00e-04 5.79e-04 0.684 -0.517 -0.448 1.24e-03 5.20e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.46e-09 6.12e-08 0.684 0.355 -0.585 1.16e-03 8.39e-08
Folding of actin by CCT/TriC 10 1.12e-03 5.34e-03 0.676 0.301 -0.605 9.88e-02 9.30e-04
Erythrocytes take up carbon dioxide and release oxygen 10 1.14e-03 5.42e-03 0.675 0.374 -0.562 4.04e-02 2.10e-03
O2/CO2 exchange in erythrocytes 10 1.14e-03 5.42e-03 0.675 0.374 -0.562 4.04e-02 2.10e-03
Creation of C4 and C2 activators 16 3.29e-05 2.05e-04 0.654 -0.624 -0.197 1.54e-05 1.73e-01
Transport of connexons to the plasma membrane 14 1.49e-04 8.38e-04 0.649 0.168 -0.627 2.76e-01 4.82e-05
Phosphorylation of CD3 and TCR zeta chains 11 1.18e-03 5.57e-03 0.637 -0.518 -0.370 2.92e-03 3.36e-02
Downregulation of ERBB2:ERBB3 signaling 13 5.59e-04 2.85e-03 0.623 0.386 -0.488 1.59e-02 2.29e-03
IRE1alpha activates chaperones 49 4.70e-13 1.28e-11 0.619 -0.389 -0.482 2.51e-06 5.31e-09
PD-1 signaling 11 1.77e-03 7.86e-03 0.617 -0.465 -0.406 7.56e-03 1.98e-02
XBP1(S) activates chaperone genes 47 2.08e-12 5.17e-11 0.615 -0.394 -0.472 2.90e-06 2.10e-08
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 3.63e-03 1.46e-02 0.610 -0.359 -0.492 4.91e-02 7.02e-03
Olfactory Signaling Pathway 25 1.04e-06 9.52e-06 0.605 0.582 0.164 4.65e-07 1.55e-01
FGFR2 ligand binding and activation 10 4.42e-03 1.73e-02 0.604 0.354 -0.489 5.24e-02 7.41e-03
Initial triggering of complement 23 3.97e-06 3.19e-05 0.599 -0.582 -0.144 1.36e-06 2.32e-01
Transferrin endocytosis and recycling 28 2.54e-07 2.69e-06 0.599 -0.377 -0.465 5.47e-04 2.05e-05
Josephin domain DUBs 10 4.81e-03 1.86e-02 0.598 0.177 -0.571 3.34e-01 1.75e-03
TP53 Regulates Transcription of Death Receptors and Ligands 10 4.88e-03 1.87e-02 0.597 0.193 -0.565 2.91e-01 1.96e-03
Regulation of expression of SLITs and ROBOs 162 1.79e-37 1.31e-35 0.594 0.408 -0.432 3.26e-19 2.32e-21
Insulin receptor recycling 26 9.61e-07 9.01e-06 0.594 -0.373 -0.462 1.01e-03 4.51e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.OAvRCA s.OAvRCR p.OAvRCA p.OAvRCR
Peptide chain elongation 87 7.78e-50 2.35e-47 0.93400 0.740000 -5.70e-01 6.05e-33 3.91e-20
SARS-CoV-1 modulates host translation machinery 36 5.10e-21 1.97e-19 0.93400 0.761000 -5.42e-01 2.71e-15 1.83e-08
Eukaryotic Translation Elongation 92 2.53e-52 3.71e-49 0.93100 0.731000 -5.77e-01 6.43e-34 1.11e-21
Viral mRNA Translation 87 4.69e-48 8.61e-46 0.91700 0.725000 -5.62e-01 1.17e-31 1.27e-19
Formation of a pool of free 40S subunits 99 4.01e-51 2.33e-48 0.88700 0.705000 -5.38e-01 5.90e-34 2.01e-20
Selenocysteine synthesis 91 2.61e-46 3.49e-44 0.88000 0.707000 -5.25e-01 1.90e-31 4.65e-18
Eukaryotic Translation Termination 91 8.08e-46 9.89e-44 0.87600 0.682000 -5.49e-01 2.03e-29 1.33e-19
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 3.46e-45 3.91e-43 0.86000 0.673000 -5.36e-01 2.81e-29 4.21e-19
L13a-mediated translational silencing of Ceruloplasmin expression 109 4.75e-51 2.33e-48 0.84500 0.664000 -5.24e-01 4.22e-33 3.29e-21
GTP hydrolysis and joining of the 60S ribosomal subunit 110 7.99e-50 2.35e-47 0.83100 0.652000 -5.16e-01 3.00e-32 8.03e-21
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 9.95e-45 1.04e-42 0.83000 0.652000 -5.13e-01 3.07e-29 1.12e-18
Formation of the ternary complex, and subsequently, the 43S complex 51 5.47e-23 2.51e-21 0.82200 0.656000 -4.95e-01 4.84e-16 9.59e-10
Cap-dependent Translation Initiation 117 2.09e-48 4.38e-46 0.79500 0.612000 -5.07e-01 2.63e-30 2.45e-21
Eukaryotic Translation Initiation 117 2.09e-48 4.38e-46 0.79500 0.612000 -5.07e-01 2.63e-30 2.45e-21
SRP-dependent cotranslational protein targeting to membrane 110 2.40e-42 2.21e-40 0.76600 0.553000 -5.30e-01 1.09e-23 7.90e-22
FCGR activation 19 5.24e-08 6.75e-07 0.76500 -0.707000 -2.90e-01 9.31e-08 2.85e-02
Translation initiation complex formation 58 1.73e-22 7.71e-21 0.76200 0.598000 -4.72e-01 3.09e-15 4.82e-10
Selenoamino acid metabolism 113 6.20e-43 6.07e-41 0.76100 0.579000 -4.94e-01 1.90e-26 1.17e-19
Gluconeogenesis 27 6.66e-11 1.53e-09 0.75700 -0.507000 -5.63e-01 5.09e-06 4.18e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.15e-22 9.27e-21 0.75400 0.582000 -4.80e-01 9.88e-15 1.86e-10
Ribosomal scanning and start codon recognition 58 8.44e-22 3.54e-20 0.75000 0.581000 -4.75e-01 1.94e-14 3.87e-10
Classical antibody-mediated complement activation 13 1.63e-05 1.09e-04 0.75000 -0.713000 -2.32e-01 8.45e-06 1.48e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.16e-08 4.38e-07 0.74300 0.355000 -6.53e-01 4.82e-03 2.21e-07
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 2.92e-05 1.86e-04 0.73400 0.252000 -6.89e-01 1.15e-01 1.68e-05
SARS-CoV-2 modulates host translation machinery 49 1.95e-17 5.85e-16 0.72700 0.608000 -3.98e-01 1.70e-13 1.47e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.45e-39 4.99e-37 0.72400 0.561000 -4.58e-01 6.39e-25 4.17e-17
Nonsense-Mediated Decay (NMD) 113 6.45e-39 4.99e-37 0.72400 0.561000 -4.58e-01 6.39e-25 4.17e-17
Expression and translocation of olfactory receptors 21 9.15e-08 1.08e-06 0.71500 0.677000 2.31e-01 7.80e-08 6.63e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 1.07e-08 1.63e-07 0.70300 0.375000 -5.94e-01 1.17e-03 2.70e-07
Scavenging of heme from plasma 13 1.00e-04 5.79e-04 0.68400 -0.517000 -4.48e-01 1.24e-03 5.20e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.46e-09 6.12e-08 0.68400 0.355000 -5.85e-01 1.16e-03 8.39e-08
Folding of actin by CCT/TriC 10 1.12e-03 5.34e-03 0.67600 0.301000 -6.05e-01 9.88e-02 9.30e-04
Erythrocytes take up carbon dioxide and release oxygen 10 1.14e-03 5.42e-03 0.67500 0.374000 -5.62e-01 4.04e-02 2.10e-03
O2/CO2 exchange in erythrocytes 10 1.14e-03 5.42e-03 0.67500 0.374000 -5.62e-01 4.04e-02 2.10e-03
Creation of C4 and C2 activators 16 3.29e-05 2.05e-04 0.65400 -0.624000 -1.97e-01 1.54e-05 1.73e-01
Transport of connexons to the plasma membrane 14 1.49e-04 8.38e-04 0.64900 0.168000 -6.27e-01 2.76e-01 4.82e-05
Phosphorylation of CD3 and TCR zeta chains 11 1.18e-03 5.57e-03 0.63700 -0.518000 -3.70e-01 2.92e-03 3.36e-02
Downregulation of ERBB2:ERBB3 signaling 13 5.59e-04 2.85e-03 0.62300 0.386000 -4.88e-01 1.59e-02 2.29e-03
IRE1alpha activates chaperones 49 4.70e-13 1.28e-11 0.61900 -0.389000 -4.82e-01 2.51e-06 5.31e-09
PD-1 signaling 11 1.77e-03 7.86e-03 0.61700 -0.465000 -4.06e-01 7.56e-03 1.98e-02
XBP1(S) activates chaperone genes 47 2.08e-12 5.17e-11 0.61500 -0.394000 -4.72e-01 2.90e-06 2.10e-08
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 3.63e-03 1.46e-02 0.61000 -0.359000 -4.92e-01 4.91e-02 7.02e-03
Olfactory Signaling Pathway 25 1.04e-06 9.52e-06 0.60500 0.582000 1.64e-01 4.65e-07 1.55e-01
FGFR2 ligand binding and activation 10 4.42e-03 1.73e-02 0.60400 0.354000 -4.89e-01 5.24e-02 7.41e-03
Initial triggering of complement 23 3.97e-06 3.19e-05 0.59900 -0.582000 -1.44e-01 1.36e-06 2.32e-01
Transferrin endocytosis and recycling 28 2.54e-07 2.69e-06 0.59900 -0.377000 -4.65e-01 5.47e-04 2.05e-05
Josephin domain DUBs 10 4.81e-03 1.86e-02 0.59800 0.177000 -5.71e-01 3.34e-01 1.75e-03
TP53 Regulates Transcription of Death Receptors and Ligands 10 4.88e-03 1.87e-02 0.59700 0.193000 -5.65e-01 2.91e-01 1.96e-03
Regulation of expression of SLITs and ROBOs 162 1.79e-37 1.31e-35 0.59400 0.408000 -4.32e-01 3.26e-19 2.32e-21
Insulin receptor recycling 26 9.61e-07 9.01e-06 0.59400 -0.373000 -4.62e-01 1.01e-03 4.51e-05
Influenza Viral RNA Transcription and Replication 134 1.13e-30 6.14e-29 0.59000 0.461000 -3.67e-01 3.06e-20 2.11e-13
Crosslinking of collagen fibrils 14 7.07e-04 3.55e-03 0.58600 -0.290000 -5.09e-01 6.01e-02 9.84e-04
Mucopolysaccharidoses 11 3.73e-03 1.48e-02 0.58300 -0.578000 7.90e-02 9.08e-04 6.50e-01
Keratan sulfate degradation 13 1.35e-03 6.23e-03 0.58000 -0.275000 -5.11e-01 8.65e-02 1.43e-03
Interleukin-2 signaling 11 4.46e-03 1.73e-02 0.57000 -0.450000 -3.51e-01 9.78e-03 4.40e-02
Keratan sulfate biosynthesis 26 4.42e-06 3.47e-05 0.56300 0.044300 -5.61e-01 6.96e-01 7.28e-07
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 3.49e-03 1.41e-02 0.56200 -0.170000 5.36e-01 3.08e-01 1.30e-03
Glycogen synthesis 12 3.58e-03 1.44e-02 0.56200 0.321000 -4.61e-01 5.42e-02 5.67e-03
STAT3 nuclear events downstream of ALK signaling 10 9.06e-03 3.18e-02 0.55900 -0.136000 -5.42e-01 4.56e-01 2.99e-03
ABC transporters in lipid homeostasis 12 4.06e-03 1.61e-02 0.55600 -0.461000 3.10e-01 5.70e-03 6.28e-02
Packaging Of Telomere Ends 12 4.21e-03 1.66e-02 0.55400 0.434000 -3.45e-01 9.31e-03 3.87e-02
Cellular response to starvation 149 7.89e-30 3.99e-28 0.55100 0.359000 -4.19e-01 4.08e-14 1.12e-18
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 1.64e-04 9.21e-04 0.55100 -0.493000 -2.46e-01 1.97e-04 6.37e-02
Activation of Matrix Metalloproteinases 23 3.64e-05 2.24e-04 0.54300 -0.169000 -5.16e-01 1.62e-01 1.81e-05
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 3.46e-03 1.40e-02 0.53700 -0.462000 -2.74e-01 3.92e-03 8.74e-02
Syndecan interactions 26 1.38e-05 9.31e-05 0.53600 -0.020100 -5.35e-01 8.59e-01 2.29e-06
Major pathway of rRNA processing in the nucleolus and cytosol 179 8.49e-33 5.20e-31 0.52900 0.404000 -3.40e-01 1.08e-20 4.03e-15
Suppression of phagosomal maturation 13 4.56e-03 1.77e-02 0.52600 0.038800 -5.25e-01 8.08e-01 1.05e-03
Trafficking and processing of endosomal TLR 12 7.14e-03 2.60e-02 0.52500 -0.507000 1.37e-01 2.35e-03 4.11e-01
Membrane binding and targetting of GAG proteins 14 3.17e-03 1.30e-02 0.52500 0.196000 -4.87e-01 2.05e-01 1.59e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 3.17e-03 1.30e-02 0.52500 0.196000 -4.87e-01 2.05e-01 1.59e-03
Influenza Infection 153 1.18e-27 5.80e-26 0.52400 0.406000 -3.31e-01 4.57e-18 1.69e-12
Response of EIF2AK1 (HRI) to heme deficiency 14 3.34e-03 1.36e-02 0.52300 0.187000 -4.88e-01 2.25e-01 1.57e-03
Free fatty acids regulate insulin secretion 10 1.73e-02 5.56e-02 0.52200 -0.387000 3.50e-01 3.39e-02 5.50e-02
Chondroitin sulfate biosynthesis 16 1.43e-03 6.50e-03 0.52200 -0.057300 -5.19e-01 6.92e-01 3.25e-04
Collagen degradation 54 2.71e-10 5.61e-09 0.52000 -0.277000 -4.40e-01 4.41e-04 2.18e-08
rRNA processing in the nucleus and cytosol 189 2.19e-33 1.46e-31 0.51900 0.397000 -3.35e-01 5.24e-21 2.09e-15
Role of LAT2/NTAL/LAB on calcium mobilization 20 3.63e-04 1.92e-03 0.51300 -0.498000 -1.24e-01 1.16e-04 3.38e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 70 1.23e-12 3.11e-11 0.51300 0.093000 -5.04e-01 1.79e-01 3.00e-13
Striated Muscle Contraction 30 7.21e-06 5.37e-05 0.51100 -0.314000 -4.03e-01 2.92e-03 1.32e-04
Formation of ATP by chemiosmotic coupling 16 1.97e-03 8.63e-03 0.51100 0.114000 -4.98e-01 4.30e-01 5.65e-04
ATF6 (ATF6-alpha) activates chaperones 12 9.39e-03 3.28e-02 0.50900 -0.052400 -5.06e-01 7.53e-01 2.39e-03
Role of phospholipids in phagocytosis 30 9.25e-06 6.53e-05 0.50600 -0.451000 -2.30e-01 1.93e-05 2.92e-02
Aggrephagy 34 2.50e-06 2.13e-05 0.50500 0.326000 -3.86e-01 1.00e-03 9.70e-05
Collagen biosynthesis and modifying enzymes 60 9.42e-11 2.10e-09 0.50500 -0.220000 -4.55e-01 3.26e-03 1.08e-09
Interleukin-10 signaling 35 1.80e-06 1.58e-05 0.50000 -0.288000 -4.09e-01 3.14e-03 2.87e-05
Transcriptional regulation of pluripotent stem cells 16 2.57e-03 1.08e-02 0.50000 0.488000 -1.07e-01 7.24e-04 4.60e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 49 1.35e-08 1.98e-07 0.49900 0.373000 -3.32e-01 6.23e-06 5.90e-05
Translation 291 8.07e-47 1.32e-44 0.49800 0.295000 -4.01e-01 4.61e-18 5.85e-32
Ubiquitin-dependent degradation of Cyclin D 50 9.45e-09 1.46e-07 0.49700 0.047300 -4.95e-01 5.63e-01 1.39e-09
Keratan sulfate/keratin metabolism 32 7.04e-06 5.28e-05 0.49700 -0.098000 -4.87e-01 3.38e-01 1.87e-06
rRNA processing 199 3.82e-32 2.25e-30 0.49600 0.379000 -3.21e-01 3.34e-20 6.04e-15
Diseases associated with glycosaminoglycan metabolism 38 9.32e-07 8.93e-06 0.49400 -0.014800 -4.94e-01 8.74e-01 1.39e-07
Diseases associated with glycosylation precursor biosynthesis 15 4.42e-03 1.73e-02 0.49000 -0.064900 -4.86e-01 6.63e-01 1.11e-03
Post-chaperonin tubulin folding pathway 18 1.77e-03 7.86e-03 0.48600 0.207000 -4.40e-01 1.28e-01 1.23e-03
Zinc transporters 10 2.83e-02 8.24e-02 0.48600 -0.205000 -4.41e-01 2.62e-01 1.58e-02
TRAF3-dependent IRF activation pathway 13 1.05e-02 3.58e-02 0.48500 -0.438000 2.08e-01 6.21e-03 1.93e-01
Regulation of RUNX3 expression and activity 55 4.03e-09 7.05e-08 0.48400 -0.035800 -4.83e-01 6.46e-01 5.78e-10
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 1.03e-02 3.53e-02 0.48200 -0.365000 -3.16e-01 2.28e-02 4.89e-02
Signaling by ROBO receptors 201 2.55e-30 1.34e-28 0.48000 0.313000 -3.63e-01 1.95e-14 7.41e-19
The canonical retinoid cycle in rods (twilight vision) 11 2.37e-02 7.13e-02 0.47800 -0.157000 4.51e-01 3.68e-01 9.57e-03
SARS-CoV-2 modulates autophagy 11 2.34e-02 7.09e-02 0.47700 -0.477000 1.46e-02 6.14e-03 9.33e-01
Assembly of active LPL and LIPC lipase complexes 12 1.61e-02 5.19e-02 0.47700 -0.282000 -3.85e-01 9.08e-02 2.10e-02
Diseases associated with N-glycosylation of proteins 20 1.04e-03 5.03e-03 0.47700 -0.395000 -2.67e-01 2.21e-03 3.90e-02
Regulation of ornithine decarboxylase (ODC) 48 8.51e-08 1.02e-06 0.47600 0.019200 -4.76e-01 8.19e-01 1.17e-08
Assembly Of The HIV Virion 16 4.46e-03 1.73e-02 0.47600 0.124000 -4.60e-01 3.89e-01 1.46e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 6.54e-08 8.01e-07 0.47500 0.024600 -4.74e-01 7.66e-01 9.10e-09
p53-Independent DNA Damage Response 49 6.54e-08 8.01e-07 0.47500 0.024600 -4.74e-01 7.66e-01 9.10e-09
p53-Independent G1/S DNA damage checkpoint 49 6.54e-08 8.01e-07 0.47500 0.024600 -4.74e-01 7.66e-01 9.10e-09
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 9.44e-08 1.11e-06 0.47500 0.044200 -4.73e-01 5.96e-01 1.45e-08
ATF6 (ATF6-alpha) activates chaperone genes 10 3.56e-02 9.82e-02 0.47200 0.005660 -4.72e-01 9.75e-01 9.79e-03
TNFs bind their physiological receptors 19 1.70e-03 7.60e-03 0.47200 -0.431000 -1.92e-01 1.15e-03 1.47e-01
Defective CFTR causes cystic fibrosis 58 4.19e-09 7.16e-08 0.47100 -0.006000 -4.71e-01 9.37e-01 5.30e-10
Hh mutants are degraded by ERAD 53 2.25e-08 3.17e-07 0.47100 -0.009150 -4.71e-01 9.08e-01 2.98e-09
Scavenging by Class A Receptors 16 4.84e-03 1.86e-02 0.47100 -0.468000 -5.23e-02 1.19e-03 7.17e-01
SUMOylation of immune response proteins 11 2.58e-02 7.64e-02 0.46900 -0.236000 -4.05e-01 1.74e-01 2.00e-02
Synthesis of PIPs at the Golgi membrane 15 7.40e-03 2.67e-02 0.46900 -0.406000 2.34e-01 6.42e-03 1.17e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 1.04e-07 1.20e-06 0.46800 0.032000 -4.67e-01 6.99e-01 1.51e-08
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 3.15e-08 4.38e-07 0.46700 0.037700 -4.65e-01 6.35e-01 4.56e-09
HSF1 activation 25 3.07e-04 1.65e-03 0.46700 0.302000 -3.56e-01 8.99e-03 2.06e-03
RUNX3 regulates p14-ARF 10 3.84e-02 1.04e-01 0.46400 -0.245000 -3.95e-01 1.80e-01 3.07e-02
Degradation of DVL 55 2.08e-08 2.97e-07 0.46400 0.043000 -4.62e-01 5.82e-01 3.09e-09
Chemokine receptors bind chemokines 36 8.90e-06 6.32e-05 0.46300 -0.131000 -4.44e-01 1.73e-01 3.96e-06
Vif-mediated degradation of APOBEC3G 52 6.16e-08 7.74e-07 0.46200 0.057700 -4.59e-01 4.72e-01 1.04e-08
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 5.51e-08 7.04e-07 0.46000 0.076700 -4.53e-01 3.34e-01 1.14e-08
The role of Nef in HIV-1 replication and disease pathogenesis 26 2.57e-04 1.40e-03 0.46000 -0.447000 -1.08e-01 8.01e-05 3.41e-01
Retrograde neurotrophin signalling 14 1.18e-02 3.99e-02 0.45800 -0.421000 -1.82e-01 6.43e-03 2.38e-01
FGFR2 mutant receptor activation 24 5.75e-04 2.92e-03 0.45700 0.173000 -4.23e-01 1.43e-01 3.34e-04
Defective Intrinsic Pathway for Apoptosis 21 1.37e-03 6.31e-03 0.45700 -0.105000 -4.44e-01 4.04e-01 4.23e-04
ROS and RNS production in phagocytes 31 5.76e-05 3.42e-04 0.45600 -0.333000 -3.12e-01 1.31e-03 2.67e-03
Negative regulation of NOTCH4 signaling 54 5.00e-08 6.50e-07 0.45600 0.032900 -4.55e-01 6.76e-01 7.16e-09
SHC-mediated cascade:FGFR3 12 2.42e-02 7.22e-02 0.45600 0.085500 -4.48e-01 6.08e-01 7.27e-03
Assembly of collagen fibrils and other multimeric structures 54 4.76e-08 6.24e-07 0.45500 -0.209000 -4.04e-01 8.01e-03 2.73e-07
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 11 3.37e-02 9.37e-02 0.45500 0.421000 -1.73e-01 1.57e-02 3.20e-01
Hh mutants abrogate ligand secretion 55 4.31e-08 5.80e-07 0.45400 0.008800 -4.54e-01 9.10e-01 5.75e-09
Maturation of spike protein 9694548 37 1.02e-05 7.08e-05 0.45300 -0.300000 -3.40e-01 1.61e-03 3.41e-04
Collagen chain trimerization 38 8.01e-06 5.84e-05 0.45300 -0.175000 -4.17e-01 6.13e-02 8.53e-06
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 3.33e-09 5.96e-08 0.45200 0.064300 -4.48e-01 3.74e-01 5.92e-10
Antimicrobial peptides 26 3.63e-04 1.92e-03 0.45100 0.058700 -4.48e-01 6.05e-01 7.78e-05
Vpu mediated degradation of CD4 50 2.43e-07 2.61e-06 0.45100 0.020000 -4.51e-01 8.07e-01 3.48e-08
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 1.37e-07 1.52e-06 0.45100 0.021100 -4.50e-01 7.92e-01 1.93e-08
Metabolism of polyamines 56 4.40e-08 5.87e-07 0.45000 0.010000 -4.50e-01 8.97e-01 5.88e-09
Collagen formation 81 2.12e-11 5.04e-10 0.44900 -0.197000 -4.04e-01 2.24e-03 3.39e-10
Binding and Uptake of Ligands by Scavenger Receptors 38 9.86e-06 6.93e-05 0.44900 -0.414000 -1.74e-01 1.03e-05 6.36e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 3.82e-02 1.03e-01 0.44600 0.194000 -4.02e-01 2.65e-01 2.09e-02
SCF-beta-TrCP mediated degradation of Emi1 53 1.37e-07 1.52e-06 0.44600 -0.002710 -4.46e-01 9.73e-01 1.89e-08
Attenuation phase 22 1.51e-03 6.82e-03 0.44600 0.294000 -3.35e-01 1.71e-02 6.46e-03
SLBP independent Processing of Histone Pre-mRNAs 10 5.20e-02 1.30e-01 0.44600 0.219000 -3.88e-01 2.30e-01 3.35e-02
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.14e-06 1.04e-05 0.44500 -0.045800 -4.43e-01 5.91e-01 2.01e-07
Regulation of NPAS4 gene expression 12 2.76e-02 8.12e-02 0.44500 0.208000 3.93e-01 2.12e-01 1.83e-02
Dectin-1 mediated noncanonical NF-kB signaling 58 3.45e-08 4.73e-07 0.44500 -0.010600 -4.45e-01 8.89e-01 4.65e-09
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 1.55e-03 6.97e-03 0.44200 -0.072900 -4.36e-01 5.54e-01 3.97e-04
E3 ubiquitin ligases ubiquitinate target proteins 43 3.82e-06 3.11e-05 0.44200 0.289000 -3.35e-01 1.04e-03 1.47e-04
cGMP effects 13 2.15e-02 6.66e-02 0.44200 0.347000 2.74e-01 3.03e-02 8.76e-02
Cristae formation 29 2.30e-04 1.25e-03 0.44000 0.049000 -4.37e-01 6.48e-01 4.66e-05
Metabolism of Angiotensinogen to Angiotensins 13 2.28e-02 6.94e-02 0.43900 -0.135000 -4.18e-01 3.99e-01 9.05e-03
SHC-mediated cascade:FGFR4 11 4.24e-02 1.12e-01 0.43900 0.151000 -4.12e-01 3.86e-01 1.79e-02
NIK–>noncanonical NF-kB signaling 57 7.45e-08 9.04e-07 0.43900 -0.011000 -4.38e-01 8.86e-01 1.03e-08
Pexophagy 11 4.53e-02 1.17e-01 0.43500 0.326000 -2.88e-01 6.13e-02 9.77e-02
Stabilization of p53 54 2.35e-07 2.55e-06 0.43500 0.017600 -4.34e-01 8.23e-01 3.34e-08
Cohesin Loading onto Chromatin 10 5.85e-02 1.42e-01 0.43300 0.250000 3.54e-01 1.70e-01 5.28e-02
Dectin-2 family 14 2.02e-02 6.29e-02 0.43300 -0.251000 3.53e-01 1.05e-01 2.21e-02
Signaling by FGFR2 IIIa TM 19 5.01e-03 1.91e-02 0.43300 0.149000 -4.06e-01 2.61e-01 2.18e-03
Generation of second messenger molecules 21 2.64e-03 1.10e-02 0.43200 -0.321000 -2.90e-01 1.09e-02 2.16e-02
Cytosolic tRNA aminoacylation 24 1.18e-03 5.57e-03 0.43200 -0.099700 -4.20e-01 3.98e-01 3.64e-04
Regulation of BACH1 activity 11 4.70e-02 1.20e-01 0.43100 0.087000 -4.23e-01 6.17e-01 1.52e-02
GLI3 is processed to GLI3R by the proteasome 57 1.34e-07 1.52e-06 0.43100 -0.017800 -4.30e-01 8.17e-01 1.93e-08
Regulation of Apoptosis 51 7.46e-07 7.36e-06 0.43000 0.034400 -4.29e-01 6.71e-01 1.17e-07
DARPP-32 events 22 2.42e-03 1.03e-02 0.42800 0.019100 -4.27e-01 8.77e-01 5.23e-04
Cargo concentration in the ER 28 4.45e-04 2.30e-03 0.42700 -0.178000 -3.89e-01 1.03e-01 3.72e-04
TICAM1-dependent activation of IRF3/IRF7 12 3.74e-02 1.01e-01 0.42600 -0.142000 -4.02e-01 3.95e-01 1.59e-02
Unfolded Protein Response (UPR) 91 2.13e-11 5.04e-10 0.42400 -0.185000 -3.81e-01 2.27e-03 3.36e-10
SCF(Skp2)-mediated degradation of p27/p21 59 1.36e-07 1.52e-06 0.42400 0.037400 -4.22e-01 6.19e-01 2.07e-08
NF-kB is activated and signals survival 13 3.06e-02 8.77e-02 0.42300 0.017400 -4.23e-01 9.14e-01 8.31e-03
Gap junction assembly 21 3.65e-03 1.46e-02 0.42300 0.079700 -4.15e-01 5.27e-01 9.82e-04
Plasma lipoprotein assembly 11 5.39e-02 1.33e-01 0.42200 -0.370000 2.05e-01 3.38e-02 2.40e-01
SHC1 events in EGFR signaling 11 5.38e-02 1.33e-01 0.42100 -0.418000 5.14e-02 1.63e-02 7.68e-01
Degradation of GLI2 by the proteasome 57 2.66e-07 2.79e-06 0.42100 -0.004520 -4.21e-01 9.53e-01 3.76e-08
Phase 4 - resting membrane potential 11 5.51e-02 1.34e-01 0.42000 0.085200 -4.11e-01 6.25e-01 1.82e-02
Regulation of RUNX2 expression and activity 70 1.10e-08 1.66e-07 0.41900 0.008860 -4.18e-01 8.98e-01 1.41e-09
PINK1-PRKN Mediated Mitophagy 21 4.26e-03 1.67e-02 0.41800 0.219000 -3.56e-01 8.28e-02 4.69e-03
Anchoring fibril formation 11 5.48e-02 1.34e-01 0.41800 -0.183000 -3.76e-01 2.95e-01 3.07e-02
Pentose phosphate pathway 13 3.28e-02 9.18e-02 0.41800 -0.090900 -4.08e-01 5.71e-01 1.09e-02
Hedgehog ligand biogenesis 60 1.57e-07 1.73e-06 0.41800 -0.001760 -4.18e-01 9.81e-01 2.17e-08
Inhibition of DNA recombination at telomere 26 1.28e-03 5.94e-03 0.41500 0.260000 -3.24e-01 2.17e-02 4.26e-03
Regulation of Complement cascade 37 7.03e-05 4.14e-04 0.41400 -0.364000 -1.96e-01 1.26e-04 3.87e-02
Cleavage of the damaged purine 15 2.22e-02 6.79e-02 0.41400 0.301000 -2.83e-01 4.34e-02 5.75e-02
Depurination 15 2.22e-02 6.79e-02 0.41400 0.301000 -2.83e-01 4.34e-02 5.75e-02
Recognition and association of DNA glycosylase with site containing an affected purine 15 2.22e-02 6.79e-02 0.41400 0.301000 -2.83e-01 4.34e-02 5.75e-02
Activation of NF-kappaB in B cells 65 6.13e-08 7.74e-07 0.41300 0.007050 -4.13e-01 9.22e-01 8.26e-09
Beta-catenin phosphorylation cascade 17 1.33e-02 4.36e-02 0.41200 0.020700 -4.11e-01 8.83e-01 3.31e-03
Downstream TCR signaling 82 1.02e-09 2.00e-08 0.41100 -0.013600 -4.11e-01 8.31e-01 1.29e-10
Glucose metabolism 82 8.95e-10 1.80e-08 0.41100 -0.335000 -2.37e-01 1.53e-07 2.09e-04
Cellular response to hypoxia 72 1.41e-08 2.05e-07 0.41000 0.040300 -4.08e-01 5.54e-01 2.11e-09
Nuclear events mediated by NFE2L2 76 5.02e-09 8.48e-08 0.41000 0.000878 -4.10e-01 9.89e-01 6.33e-10
Other semaphorin interactions 19 8.22e-03 2.92e-02 0.41000 -0.406000 -5.86e-02 2.19e-03 6.58e-01
WNT5A-dependent internalization of FZD4 14 2.85e-02 8.26e-02 0.41000 -0.327000 -2.48e-01 3.43e-02 1.09e-01
Post-translational protein phosphorylation 78 2.89e-09 5.24e-08 0.40900 -0.180000 -3.68e-01 6.06e-03 2.00e-08
Sealing of the nuclear envelope (NE) by ESCRT-III 24 2.51e-03 1.06e-02 0.40900 0.111000 -3.94e-01 3.47e-01 8.44e-04
Degradation of GLI1 by the proteasome 57 6.47e-07 6.51e-06 0.40900 -0.011200 -4.09e-01 8.84e-01 9.53e-08
Degradation of cysteine and homocysteine 12 4.90e-02 1.25e-01 0.40800 -0.188000 -3.62e-01 2.59e-01 3.00e-02
Degradation of beta-catenin by the destruction complex 83 1.15e-09 2.23e-08 0.40800 0.057800 -4.04e-01 3.63e-01 2.03e-10
Interconversion of nucleotide di- and triphosphates 27 1.26e-03 5.89e-03 0.40700 0.107000 -3.93e-01 3.36e-01 4.09e-04
Assembly and cell surface presentation of NMDA receptors 34 2.29e-04 1.25e-03 0.40700 0.168000 -3.71e-01 8.94e-02 1.84e-04
SHC-mediated cascade:FGFR2 14 3.13e-02 8.90e-02 0.40700 0.089000 -3.97e-01 5.64e-01 1.01e-02
Activation of AMPK downstream of NMDARs 21 5.71e-03 2.14e-02 0.40700 0.277000 -2.98e-01 2.82e-02 1.79e-02
TRAF6 mediated IRF7 activation 15 2.51e-02 7.46e-02 0.40600 -0.366000 1.77e-01 1.42e-02 2.34e-01
Interleukin-15 signaling 14 3.08e-02 8.81e-02 0.40500 -0.314000 -2.57e-01 4.21e-02 9.64e-02
Regulation of IFNA/IFNB signaling 12 5.09e-02 1.28e-01 0.40500 -0.316000 -2.54e-01 5.82e-02 1.28e-01
Asymmetric localization of PCP proteins 61 3.45e-07 3.57e-06 0.40400 -0.017600 -4.03e-01 8.12e-01 5.10e-08
GAB1 signalosome 14 3.38e-02 9.38e-02 0.40300 -0.368000 1.65e-01 1.72e-02 2.84e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 6.99e-02 1.63e-01 0.40300 0.141000 -3.77e-01 4.18e-01 3.02e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 95 8.75e-11 1.98e-09 0.40300 -0.358000 -1.85e-01 1.73e-09 1.84e-03
Degradation of AXIN 53 2.75e-06 2.32e-05 0.40200 0.013500 -4.02e-01 8.65e-01 4.22e-07
COPI-mediated anterograde transport 92 2.26e-10 4.74e-09 0.40200 -0.026700 -4.01e-01 6.58e-01 3.01e-11
Processing and activation of SUMO 10 9.13e-02 1.99e-01 0.40100 0.256000 -3.10e-01 1.62e-01 9.01e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 1.28e-02 4.22e-02 0.40100 -0.078000 -3.94e-01 5.67e-01 3.84e-03
Neurodegenerative Diseases 18 1.28e-02 4.22e-02 0.40100 -0.078000 -3.94e-01 5.67e-01 3.84e-03
Cholesterol biosynthesis 26 2.03e-03 8.87e-03 0.40100 0.333000 -2.23e-01 3.30e-03 4.94e-02
Other interleukin signaling 20 7.99e-03 2.85e-02 0.40000 -0.369000 -1.55e-01 4.30e-03 2.30e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 10 9.28e-02 2.01e-01 0.40000 -0.253000 3.10e-01 1.66e-01 8.99e-02
The activation of arylsulfatases 10 9.08e-02 1.99e-01 0.39900 -0.149000 -3.70e-01 4.14e-01 4.29e-02
P2Y receptors 11 7.14e-02 1.65e-01 0.39800 0.207000 3.41e-01 2.35e-01 5.04e-02
FOXO-mediated transcription of cell cycle genes 15 2.85e-02 8.26e-02 0.39800 0.393000 -6.46e-02 8.38e-03 6.65e-01
Pausing and recovery of Tat-mediated HIV elongation 30 8.17e-04 4.04e-03 0.39800 0.068500 -3.92e-01 5.16e-01 1.99e-04
Tat-mediated HIV elongation arrest and recovery 30 8.17e-04 4.04e-03 0.39800 0.068500 -3.92e-01 5.16e-01 1.99e-04
Nitric oxide stimulates guanylate cyclase 16 2.20e-02 6.78e-02 0.39700 0.314000 2.44e-01 2.97e-02 9.17e-02
Signaling by ALK 26 2.18e-03 9.46e-03 0.39600 -0.115000 -3.79e-01 3.12e-01 8.29e-04
NGF-stimulated transcription 35 2.94e-04 1.59e-03 0.39600 0.227000 -3.24e-01 2.00e-02 9.15e-04
Mitochondrial translation elongation 88 1.46e-09 2.79e-08 0.39500 0.212000 -3.33e-01 5.98e-04 6.48e-08
Regulation of KIT signaling 16 2.40e-02 7.19e-02 0.39400 -0.389000 -5.89e-02 7.01e-03 6.84e-01
Regulation of TP53 Activity through Association with Co-factors 10 9.65e-02 2.07e-01 0.39400 -0.155000 -3.62e-01 3.95e-01 4.77e-02
TNFR2 non-canonical NF-kB pathway 87 1.62e-09 3.06e-08 0.39300 -0.134000 -3.70e-01 3.13e-02 2.43e-09
Complement cascade 41 7.05e-05 4.14e-04 0.39300 -0.358000 -1.62e-01 7.20e-05 7.23e-02
GRB2 events in EGFR signaling 10 1.01e-01 2.15e-01 0.39200 -0.364000 1.45e-01 4.62e-02 4.26e-01
PI-3K cascade:FGFR4 11 8.07e-02 1.82e-01 0.39200 0.355000 -1.67e-01 4.17e-02 3.37e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 87 1.92e-09 3.58e-08 0.39200 -0.129000 -3.70e-01 3.70e-02 2.49e-09
p53-Dependent G1 DNA Damage Response 62 6.75e-07 6.70e-06 0.39100 0.002630 -3.91e-01 9.71e-01 9.78e-08
p53-Dependent G1/S DNA damage checkpoint 62 6.75e-07 6.70e-06 0.39100 0.002630 -3.91e-01 9.71e-01 9.78e-08
Complex I biogenesis 51 1.05e-05 7.26e-05 0.38900 0.167000 -3.51e-01 3.91e-02 1.43e-05
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 1.89e-07 2.07e-06 0.38800 0.087700 -3.78e-01 2.08e-01 5.59e-08
Orc1 removal from chromatin 67 3.05e-07 3.18e-06 0.38700 0.045900 -3.85e-01 5.16e-01 5.19e-08
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 5.46e-03 2.06e-02 0.38700 -0.309000 -2.33e-01 1.03e-02 5.31e-02
FCGR3A-mediated IL10 synthesis 43 6.20e-05 3.67e-04 0.38700 -0.361000 -1.39e-01 4.18e-05 1.16e-01
Unwinding of DNA 11 8.52e-02 1.90e-01 0.38700 0.015100 -3.86e-01 9.31e-01 2.65e-02
Assembly of the ORC complex at the origin of replication 14 4.43e-02 1.16e-01 0.38600 0.374000 -9.61e-02 1.54e-02 5.34e-01
Cellular hexose transport 13 5.47e-02 1.34e-01 0.38500 -0.377000 -8.16e-02 1.87e-02 6.10e-01
KEAP1-NFE2L2 pathway 101 1.87e-10 3.98e-09 0.38500 -0.028800 -3.84e-01 6.17e-01 2.56e-11
Mitochondrial translation termination 88 4.11e-09 7.10e-08 0.38500 0.215000 -3.19e-01 4.89e-04 2.29e-07
Mitochondrial iron-sulfur cluster biogenesis 13 5.80e-02 1.41e-01 0.38400 0.176000 -3.41e-01 2.73e-01 3.32e-02
Protein methylation 15 3.75e-02 1.02e-01 0.38300 0.351000 -1.53e-01 1.84e-02 3.04e-01
G1/S DNA Damage Checkpoints 63 1.01e-06 9.29e-06 0.38300 0.004120 -3.83e-01 9.55e-01 1.48e-07
Iron uptake and transport 55 5.66e-06 4.35e-05 0.38200 -0.133000 -3.58e-01 8.90e-02 4.31e-06
Maturation of nucleoprotein 9683610 11 9.13e-02 1.99e-01 0.38200 -0.377000 6.03e-02 3.05e-02 7.29e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 5.38e-05 3.22e-04 0.38100 -0.140000 -3.54e-01 1.05e-01 3.92e-05
Formation of annular gap junctions 11 9.09e-02 1.99e-01 0.38000 -0.354000 -1.38e-01 4.19e-02 4.28e-01
Defects in cobalamin (B12) metabolism 12 7.32e-02 1.68e-01 0.38000 0.337000 1.76e-01 4.33e-02 2.93e-01
Metal ion SLC transporters 18 1.98e-02 6.24e-02 0.38000 -0.173000 -3.38e-01 2.05e-01 1.29e-02
N-Glycan antennae elongation 13 6.14e-02 1.48e-01 0.37900 0.069500 -3.73e-01 6.65e-01 2.00e-02
Mitochondrial translation initiation 88 7.74e-09 1.24e-07 0.37900 0.212000 -3.13e-01 5.81e-04 3.76e-07
Mitochondrial protein import 63 1.49e-06 1.34e-05 0.37800 0.052600 -3.74e-01 4.70e-01 2.81e-07
COPI-dependent Golgi-to-ER retrograde traffic 85 1.26e-08 1.88e-07 0.37800 -0.083000 -3.68e-01 1.86e-01 4.31e-09
Interleukin receptor SHC signaling 22 9.10e-03 3.19e-02 0.37700 -0.373000 -5.38e-02 2.44e-03 6.62e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 1.18e-01 2.40e-01 0.37700 0.367000 8.46e-02 4.45e-02 6.43e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 5.02e-02 1.27e-01 0.37600 -0.267000 -2.64e-01 8.32e-02 8.71e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 2.80e-02 8.18e-02 0.37400 -0.356000 -1.12e-01 1.10e-02 4.23e-01
MASTL Facilitates Mitotic Progression 10 1.25e-01 2.47e-01 0.37400 0.103000 -3.59e-01 5.71e-01 4.94e-02
FCERI mediated NF-kB activation 81 4.49e-08 5.94e-07 0.37300 -0.065600 -3.68e-01 3.07e-01 1.08e-08
Late SARS-CoV-2 Infection Events 66 9.57e-07 9.01e-06 0.37300 -0.262000 -2.66e-01 2.37e-04 1.88e-04
Translation of Structural Proteins 9683701 29 2.29e-03 9.91e-03 0.37300 -0.202000 -3.13e-01 5.98e-02 3.53e-03
Plasma lipoprotein remodeling 19 1.88e-02 6.00e-02 0.37200 -0.338000 -1.56e-01 1.07e-02 2.41e-01
Regulation of PTEN stability and activity 67 9.78e-07 9.09e-06 0.37200 0.042300 -3.70e-01 5.50e-01 1.68e-07
COPII-mediated vesicle transport 63 2.02e-06 1.76e-05 0.37200 -0.192000 -3.18e-01 8.49e-03 1.25e-05
Somitogenesis 50 3.31e-05 2.06e-04 0.37100 -0.012500 -3.71e-01 8.78e-01 5.68e-06
Interleukin-4 and Interleukin-13 signaling 90 9.36e-09 1.46e-07 0.37000 -0.042400 -3.68e-01 4.87e-01 1.60e-09
Translation of Structural Proteins 9694635 57 7.52e-06 5.58e-05 0.37000 -0.248000 -2.75e-01 1.22e-03 3.25e-04
APC/C:Cdc20 mediated degradation of Securin 66 1.37e-06 1.24e-05 0.37000 0.047600 -3.67e-01 5.04e-01 2.48e-07
Negative regulation of FGFR3 signaling 23 9.13e-03 3.19e-02 0.37000 0.118000 -3.51e-01 3.27e-01 3.58e-03
ABC transporter disorders 68 9.36e-07 8.93e-06 0.36900 -0.046200 -3.66e-01 5.11e-01 1.77e-07
Budding and maturation of HIV virion 27 4.25e-03 1.67e-02 0.36900 0.175000 -3.25e-01 1.16e-01 3.48e-03
Interleukin-2 family signaling 36 6.52e-04 3.30e-03 0.36800 -0.362000 -6.70e-02 1.70e-04 4.87e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 2.40e-06 2.07e-05 0.36800 0.047500 -3.65e-01 5.11e-01 4.41e-07
Transcriptional regulation by RUNX3 94 5.89e-09 9.81e-08 0.36800 0.042400 -3.65e-01 4.78e-01 9.28e-10
Abortive elongation of HIV-1 transcript in the absence of Tat 23 9.72e-03 3.37e-02 0.36700 0.058500 -3.63e-01 6.27e-01 2.62e-03
DCC mediated attractive signaling 13 7.07e-02 1.64e-01 0.36700 0.246000 2.73e-01 1.25e-01 8.87e-02
Hyaluronan metabolism 16 3.97e-02 1.06e-01 0.36700 -0.365000 -3.10e-02 1.14e-02 8.30e-01
RHO GTPases activate PKNs 36 7.25e-04 3.62e-03 0.36600 0.366000 -1.99e-02 1.46e-04 8.37e-01
Lysosome Vesicle Biogenesis 33 1.29e-03 5.99e-03 0.36600 -0.352000 -9.94e-02 4.63e-04 3.23e-01
Common Pathway of Fibrin Clot Formation 10 1.35e-01 2.60e-01 0.36500 -0.086200 -3.55e-01 6.37e-01 5.21e-02
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 1.11e-01 2.29e-01 0.36500 -0.081300 -3.56e-01 6.41e-01 4.12e-02
RHO GTPases activate IQGAPs 24 8.57e-03 3.03e-02 0.36500 0.092500 -3.53e-01 4.33e-01 2.78e-03
HSF1-dependent transactivation 32 1.86e-03 8.20e-03 0.36400 0.209000 -2.98e-01 4.05e-02 3.59e-03
Respiratory electron transport 93 1.17e-08 1.75e-07 0.36400 0.117000 -3.44e-01 5.20e-02 9.46e-09
Synthesis of PE 12 9.39e-02 2.03e-01 0.36300 -0.353000 8.45e-02 3.40e-02 6.12e-01
ER to Golgi Anterograde Transport 141 8.50e-13 2.19e-11 0.36300 -0.067700 -3.57e-01 1.66e-01 2.62e-13
Negative regulation of FGFR4 signaling 22 1.36e-02 4.45e-02 0.36200 0.152000 -3.29e-01 2.17e-01 7.60e-03
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 3.48e-02 9.63e-02 0.36200 -0.288000 -2.19e-01 4.00e-02 1.18e-01
TNFR1-induced proapoptotic signaling 25 7.66e-03 2.76e-02 0.35900 -0.301000 -1.96e-01 9.20e-03 8.99e-02
Mitochondrial translation 94 1.60e-08 2.31e-07 0.35900 0.202000 -2.97e-01 7.22e-04 6.53e-07
VLDLR internalisation and degradation 15 5.41e-02 1.33e-01 0.35900 -0.226000 -2.79e-01 1.31e-01 6.16e-02
Glycosphingolipid metabolism 36 9.55e-04 4.68e-03 0.35800 -0.310000 -1.79e-01 1.31e-03 6.25e-02
Transcriptional regulation by RUNX2 114 3.52e-10 7.19e-09 0.35800 -0.021000 -3.57e-01 6.99e-01 4.62e-11
Integrin cell surface interactions 73 8.34e-07 8.11e-06 0.35700 -0.082700 -3.48e-01 2.22e-01 2.79e-07
Response of Mtb to phagocytosis 23 1.22e-02 4.10e-02 0.35700 -0.065100 -3.51e-01 5.89e-01 3.56e-03
Glycolysis 65 4.23e-06 3.36e-05 0.35500 -0.294000 -1.99e-01 4.09e-05 5.51e-03
p75NTR signals via NF-kB 16 4.93e-02 1.25e-01 0.35400 0.016200 -3.54e-01 9.11e-01 1.42e-02
RAS processing 21 2.00e-02 6.26e-02 0.35400 0.215000 -2.81e-01 8.79e-02 2.57e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 1.07e-01 2.24e-01 0.35300 -0.038200 3.51e-01 8.19e-01 3.54e-02
Mitophagy 28 5.66e-03 2.13e-02 0.35200 0.113000 -3.34e-01 3.02e-01 2.24e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 9.48e-10 1.88e-08 0.35200 0.108000 -3.35e-01 4.80e-02 7.63e-10
PI-3K cascade:FGFR3 12 1.10e-01 2.29e-01 0.35200 0.272000 -2.23e-01 1.03e-01 1.81e-01
TCR signaling 102 6.54e-09 1.06e-07 0.35100 -0.072500 -3.44e-01 2.06e-01 2.02e-09
Establishment of Sister Chromatid Cohesion 11 1.29e-01 2.53e-01 0.35100 0.215000 2.77e-01 2.17e-01 1.11e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 1.30e-01 2.54e-01 0.35100 -0.341000 -8.33e-02 5.04e-02 6.32e-01
alpha-linolenic acid (ALA) metabolism 11 1.30e-01 2.54e-01 0.35100 -0.341000 -8.33e-02 5.04e-02 6.32e-01
Negative regulation of FGFR2 signaling 25 1.03e-02 3.53e-02 0.35100 0.117000 -3.30e-01 3.10e-01 4.24e-03
CS/DS degradation 11 1.32e-01 2.56e-01 0.35000 -0.096500 -3.36e-01 5.80e-01 5.35e-02
Translesion Synthesis by POLH 18 3.85e-02 1.04e-01 0.34900 0.224000 -2.68e-01 9.98e-02 4.94e-02
IL-6-type cytokine receptor ligand interactions 13 9.48e-02 2.04e-01 0.34800 0.077500 -3.40e-01 6.29e-01 3.40e-02
CTNNB1 S33 mutants aren’t phosphorylated 15 6.65e-02 1.57e-01 0.34800 0.071200 -3.40e-01 6.33e-01 2.24e-02
CTNNB1 S37 mutants aren’t phosphorylated 15 6.65e-02 1.57e-01 0.34800 0.071200 -3.40e-01 6.33e-01 2.24e-02
CTNNB1 S45 mutants aren’t phosphorylated 15 6.65e-02 1.57e-01 0.34800 0.071200 -3.40e-01 6.33e-01 2.24e-02
CTNNB1 T41 mutants aren’t phosphorylated 15 6.65e-02 1.57e-01 0.34800 0.071200 -3.40e-01 6.33e-01 2.24e-02
Signaling by CTNNB1 phospho-site mutants 15 6.65e-02 1.57e-01 0.34800 0.071200 -3.40e-01 6.33e-01 2.24e-02
Signaling by GSK3beta mutants 15 6.65e-02 1.57e-01 0.34800 0.071200 -3.40e-01 6.33e-01 2.24e-02
Downstream signaling events of B Cell Receptor (BCR) 78 9.26e-07 8.93e-06 0.34600 0.058500 -3.41e-01 3.72e-01 1.96e-07
CD28 dependent Vav1 pathway 11 1.41e-01 2.70e-01 0.34500 -0.339000 6.32e-02 5.14e-02 7.17e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 2.77e-02 8.12e-02 0.34500 -0.149000 -3.11e-01 2.49e-01 1.61e-02
Protein ubiquitination 63 1.50e-05 1.01e-04 0.34500 0.159000 -3.06e-01 2.92e-02 2.70e-05
Interleukin-6 family signaling 20 2.92e-02 8.42e-02 0.34400 0.097100 -3.30e-01 4.52e-01 1.06e-02
Signalling to RAS 20 2.80e-02 8.18e-02 0.34400 -0.225000 -2.60e-01 8.10e-02 4.44e-02
Selective autophagy 71 4.11e-06 3.28e-05 0.34300 0.201000 -2.78e-01 3.34e-03 5.14e-05
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 3.26e-06 2.72e-05 0.34300 0.005210 -3.43e-01 9.39e-01 5.00e-07
HIV elongation arrest and recovery 32 3.68e-03 1.46e-02 0.34300 0.059500 -3.37e-01 5.61e-01 9.58e-04
Pausing and recovery of HIV elongation 32 3.68e-03 1.46e-02 0.34300 0.059500 -3.37e-01 5.61e-01 9.58e-04
Glycosaminoglycan metabolism 108 5.95e-09 9.81e-08 0.34200 -0.162000 -3.01e-01 3.71e-03 6.66e-08
Assembly of the pre-replicative complex 88 2.40e-07 2.59e-06 0.34100 0.101000 -3.26e-01 1.00e-01 1.26e-07
Polo-like kinase mediated events 14 8.50e-02 1.90e-01 0.34100 -0.214000 -2.66e-01 1.67e-01 8.46e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.18e-02 1.30e-01 0.34100 -0.002040 -3.41e-01 9.88e-01 1.50e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.18e-02 1.30e-01 0.34100 -0.002040 -3.41e-01 9.88e-01 1.50e-02
SARS-CoV-1-host interactions 94 1.02e-07 1.19e-06 0.34000 0.268000 -2.10e-01 7.25e-06 4.43e-04
Processing of Intronless Pre-mRNAs 20 3.30e-02 9.23e-02 0.33900 -0.204000 2.70e-01 1.13e-01 3.65e-02
Elastic fibre formation 40 1.02e-03 4.97e-03 0.33800 -0.125000 -3.14e-01 1.70e-01 5.91e-04
Endosomal Sorting Complex Required For Transport (ESCRT) 30 6.14e-03 2.26e-02 0.33800 0.141000 -3.07e-01 1.81e-01 3.62e-03
Interleukin-1 signaling 109 8.80e-09 1.39e-07 0.33800 -0.028000 -3.36e-01 6.13e-01 1.32e-09
MECP2 regulates neuronal receptors and channels 15 7.90e-02 1.79e-01 0.33800 0.219000 -2.57e-01 1.42e-01 8.52e-02
Gastrin-CREB signalling pathway via PKC and MAPK 16 6.74e-02 1.58e-01 0.33700 -0.273000 1.98e-01 5.89e-02 1.71e-01
DNA methylation 10 1.85e-01 3.29e-01 0.33700 0.287000 -1.76e-01 1.16e-01 3.34e-01
Signaling by BMP 23 1.99e-02 6.25e-02 0.33700 0.332000 5.27e-02 5.78e-03 6.62e-01
NR1H2 and NR1H3-mediated signaling 39 1.42e-03 6.48e-03 0.33700 -0.292000 1.68e-01 1.63e-03 6.96e-02
rRNA modification in the nucleus and cytosol 59 5.20e-05 3.13e-04 0.33600 0.208000 -2.64e-01 5.73e-03 4.62e-04
Lewis blood group biosynthesis 10 1.86e-01 3.30e-01 0.33600 0.100000 -3.20e-01 5.83e-01 7.95e-02
Transport to the Golgi and subsequent modification 166 7.41e-13 1.98e-11 0.33600 -0.087800 -3.24e-01 5.13e-02 6.17e-13
Long-term potentiation 19 4.14e-02 1.10e-01 0.33500 0.103000 -3.19e-01 4.39e-01 1.60e-02
CDK-mediated phosphorylation and removal of Cdc6 70 8.03e-06 5.84e-05 0.33500 0.034700 -3.33e-01 6.16e-01 1.42e-06
Pyrimidine salvage 10 1.84e-01 3.27e-01 0.33500 -0.123000 -3.12e-01 4.99e-01 8.79e-02
Serotonin Neurotransmitter Release Cycle 15 8.00e-02 1.80e-01 0.33500 -0.040400 -3.32e-01 7.86e-01 2.58e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 72 5.94e-06 4.50e-05 0.33500 0.019600 -3.34e-01 7.74e-01 9.59e-07
Acetylcholine Neurotransmitter Release Cycle 13 1.14e-01 2.35e-01 0.33400 -0.026600 -3.33e-01 8.68e-01 3.77e-02
Late endosomal microautophagy 31 5.83e-03 2.17e-02 0.33400 0.113000 -3.14e-01 2.78e-01 2.46e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 5.27e-06 4.10e-05 0.33400 0.008640 -3.34e-01 8.99e-01 8.24e-07
Acyl chain remodelling of PC 17 6.10e-02 1.48e-01 0.33300 -0.145000 2.99e-01 3.00e-01 3.28e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 1.16e-02 3.95e-02 0.33200 0.009420 -3.32e-01 9.32e-01 2.84e-03
Glycogen storage diseases 13 1.18e-01 2.40e-01 0.33200 0.042000 -3.29e-01 7.93e-01 3.99e-02
G-protein beta:gamma signalling 27 1.26e-02 4.20e-02 0.33000 -0.249000 2.17e-01 2.51e-02 5.08e-02
Interleukin-35 Signalling 10 1.92e-01 3.38e-01 0.33000 -0.223000 -2.44e-01 2.22e-01 1.82e-01
Inactivation of CSF3 (G-CSF) signaling 24 1.98e-02 6.24e-02 0.33000 0.003240 -3.30e-01 9.78e-01 5.11e-03
LDL clearance 17 6.31e-02 1.52e-01 0.33000 -0.321000 7.62e-02 2.19e-02 5.87e-01
Regulation of RAS by GAPs 65 2.62e-05 1.71e-04 0.33000 0.033400 -3.28e-01 6.41e-01 4.80e-06
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 1.19e-05 8.04e-05 0.32900 0.022600 -3.29e-01 7.44e-01 1.99e-06
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 1.19e-05 8.04e-05 0.32900 0.022600 -3.29e-01 7.44e-01 1.99e-06
CTLA4 inhibitory signaling 19 4.48e-02 1.16e-01 0.32900 -0.126000 -3.04e-01 3.40e-01 2.18e-02
Dopamine Neurotransmitter Release Cycle 20 3.93e-02 1.06e-01 0.32900 0.038100 -3.27e-01 7.68e-01 1.14e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 4.94e-03 1.89e-02 0.32700 -0.079800 -3.17e-01 4.28e-01 1.61e-03
Unblocking of NMDA receptors, glutamate binding and activation 17 6.71e-02 1.58e-01 0.32700 0.156000 -2.88e-01 2.67e-01 4.01e-02
Cyclin E associated events during G1/S transition 81 2.45e-06 2.11e-05 0.32700 0.010700 -3.27e-01 8.68e-01 3.74e-07
Calnexin/calreticulin cycle 26 1.59e-02 5.14e-02 0.32500 -0.129000 -2.98e-01 2.53e-01 8.50e-03
Costimulation by the CD28 family 53 2.20e-04 1.21e-03 0.32500 -0.277000 -1.69e-01 4.78e-04 3.38e-02
Metabolism of amino acids and derivatives 315 1.01e-21 4.13e-20 0.32400 0.170000 -2.76e-01 2.28e-07 4.43e-17
Cleavage of the damaged pyrimidine 20 4.46e-02 1.16e-01 0.32400 0.244000 -2.13e-01 5.91e-02 9.94e-02
Depyrimidination 20 4.46e-02 1.16e-01 0.32400 0.244000 -2.13e-01 5.91e-02 9.94e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 20 4.46e-02 1.16e-01 0.32400 0.244000 -2.13e-01 5.91e-02 9.94e-02
PI-3K cascade:FGFR2 14 1.15e-01 2.38e-01 0.32200 0.249000 -2.05e-01 1.07e-01 1.85e-01
Asparagine N-linked glycosylation 278 2.60e-19 9.31e-18 0.32200 -0.118000 -2.99e-01 7.42e-04 9.43e-18
Amino acid transport across the plasma membrane 20 4.45e-02 1.16e-01 0.32100 -0.265000 -1.81e-01 4.02e-02 1.61e-01
Synthesis of PIPs at the early endosome membrane 16 8.62e-02 1.91e-01 0.32100 -0.151000 2.83e-01 2.94e-01 5.01e-02
Infection with Mycobacterium tuberculosis 27 1.55e-02 5.03e-02 0.32000 -0.087000 -3.08e-01 4.34e-01 5.57e-03
PCP/CE pathway 87 1.61e-06 1.44e-05 0.32000 -0.052200 -3.16e-01 4.01e-01 3.60e-07
Lysine catabolism 11 1.86e-01 3.30e-01 0.32000 -0.049300 3.16e-01 7.77e-01 6.96e-02
Amino acids regulate mTORC1 50 4.45e-04 2.30e-03 0.32000 -0.224000 -2.28e-01 6.06e-03 5.35e-03
RHOBTB1 GTPase cycle 23 2.87e-02 8.30e-02 0.32000 0.249000 2.00e-01 3.88e-02 9.61e-02
Metabolism of carbohydrates 254 1.68e-17 5.14e-16 0.31900 -0.187000 -2.59e-01 3.18e-07 1.27e-12
COPI-independent Golgi-to-ER retrograde traffic 45 1.11e-03 5.33e-03 0.31900 0.130000 -2.91e-01 1.31e-01 7.33e-04
Base-Excision Repair, AP Site Formation 22 3.66e-02 1.00e-01 0.31800 0.214000 -2.35e-01 8.20e-02 5.62e-02
Cyclin A:Cdk2-associated events at S phase entry 83 3.69e-06 3.03e-05 0.31800 -0.001100 -3.18e-01 9.86e-01 5.69e-07
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 4.94e-03 1.89e-02 0.31700 -0.127000 -2.91e-01 1.95e-01 2.90e-03
AKT phosphorylates targets in the cytosol 14 1.21e-01 2.42e-01 0.31700 -0.018000 -3.17e-01 9.07e-01 4.02e-02
Regulation of APC/C activators between G1/S and early anaphase 78 8.46e-06 6.06e-05 0.31600 -0.018900 -3.16e-01 7.73e-01 1.42e-06
GPVI-mediated activation cascade 32 8.22e-03 2.92e-02 0.31600 -0.315000 -2.75e-02 2.04e-03 7.88e-01
A tetrasaccharide linker sequence is required for GAG synthesis 22 3.64e-02 9.98e-02 0.31600 -0.089900 -3.03e-01 4.66e-01 1.38e-02
Formation of the beta-catenin:TCF transactivating complex 36 4.80e-03 1.86e-02 0.31600 0.185000 -2.56e-01 5.47e-02 7.80e-03
Gap junction degradation 12 1.65e-01 3.06e-01 0.31600 -0.309000 -6.39e-02 6.37e-02 7.01e-01
TCF dependent signaling in response to WNT 160 5.56e-11 1.30e-09 0.31600 0.073200 -3.07e-01 1.11e-01 2.11e-11
Trafficking of GluR2-containing AMPA receptors 14 1.25e-01 2.47e-01 0.31400 -0.277000 -1.48e-01 7.30e-02 3.37e-01
Elevation of cytosolic Ca2+ levels 13 1.46e-01 2.77e-01 0.31300 -0.180000 -2.56e-01 2.60e-01 1.10e-01
Cell surface interactions at the vascular wall 111 7.74e-08 9.32e-07 0.31300 -0.219000 -2.23e-01 6.53e-05 4.87e-05
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.25e-02 4.20e-02 0.31300 0.060700 -3.07e-01 5.65e-01 3.63e-03
Downregulation of TGF-beta receptor signaling 26 2.33e-02 7.08e-02 0.31200 0.227000 -2.14e-01 4.54e-02 5.84e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 1.10e-01 2.29e-01 0.31200 0.250000 1.87e-01 9.41e-02 2.09e-01
Golgi-to-ER retrograde transport 118 3.54e-08 4.81e-07 0.31200 -0.042900 -3.09e-01 4.21e-01 6.84e-09
tRNA Aminoacylation 42 2.19e-03 9.48e-03 0.31100 -0.141000 -2.77e-01 1.14e-01 1.89e-03
Maturation of nucleoprotein 9694631 15 1.14e-01 2.35e-01 0.31100 -0.310000 -1.85e-02 3.76e-02 9.01e-01
NPAS4 regulates expression of target genes 18 7.57e-02 1.73e-01 0.31100 0.189000 -2.47e-01 1.65e-01 7.01e-02
Hedgehog ‘on’ state 82 7.65e-06 5.64e-05 0.31000 -0.013000 -3.10e-01 8.39e-01 1.25e-06
ER-Phagosome pathway 79 1.16e-05 7.96e-05 0.30900 -0.116000 -2.87e-01 7.55e-02 1.05e-05
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 1.08e-02 3.67e-02 0.30900 -0.232000 2.04e-01 2.30e-02 4.63e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 1.20e-01 2.41e-01 0.30800 0.048900 -3.04e-01 7.43e-01 4.17e-02
Senescence-Associated Secretory Phenotype (SASP) 56 3.79e-04 2.00e-03 0.30800 0.097000 -2.92e-01 2.09e-01 1.59e-04
Chaperone Mediated Autophagy 19 6.97e-02 1.62e-01 0.30700 0.214000 -2.20e-01 1.06e-01 9.66e-02
Transport of bile salts and organic acids, metal ions and amine compounds 46 1.43e-03 6.51e-03 0.30700 -0.152000 -2.67e-01 7.51e-02 1.72e-03
MET activates RAP1 and RAC1 11 2.10e-01 3.61e-01 0.30700 0.097000 2.91e-01 5.77e-01 9.46e-02
Norepinephrine Neurotransmitter Release Cycle 15 1.21e-01 2.42e-01 0.30600 -0.021700 -3.06e-01 8.84e-01 4.05e-02
Switching of origins to a post-replicative state 88 4.60e-06 3.60e-05 0.30600 0.054900 -3.01e-01 3.74e-01 1.03e-06
CLEC7A (Dectin-1) signaling 95 1.67e-06 1.49e-05 0.30600 -0.043700 -3.03e-01 4.62e-01 3.42e-07
Inflammasomes 21 5.21e-02 1.30e-01 0.30500 -0.255000 -1.68e-01 4.32e-02 1.83e-01
Peroxisomal lipid metabolism 26 2.83e-02 8.24e-02 0.30400 -0.132000 2.73e-01 2.43e-01 1.59e-02
TRP channels 20 6.48e-02 1.55e-01 0.30400 -0.210000 2.19e-01 1.04e-01 8.99e-02
Negative regulation of MAPK pathway 42 3.12e-03 1.29e-02 0.30400 0.064200 -2.97e-01 4.71e-01 8.81e-04
Caspase activation via extrinsic apoptotic signalling pathway 23 4.13e-02 1.10e-01 0.30400 -0.295000 -7.33e-02 1.45e-02 5.43e-01
Pregnenolone biosynthesis 10 2.50e-01 4.10e-01 0.30300 -0.248000 -1.74e-01 1.74e-01 3.41e-01
FRS-mediated FGFR4 signaling 13 1.70e-01 3.11e-01 0.30300 0.230000 -1.97e-01 1.50e-01 2.20e-01
Regulation of CDH11 gene transcription 10 2.51e-01 4.11e-01 0.30200 -0.208000 -2.19e-01 2.55e-01 2.30e-01
Degradation of the extracellular matrix 110 3.56e-07 3.65e-06 0.30000 -0.175000 -2.43e-01 1.54e-03 1.06e-05
Interleukin-7 signaling 19 7.81e-02 1.77e-01 0.30000 0.025100 -2.98e-01 8.50e-01 2.43e-02
Ras activation upon Ca2+ influx through NMDA receptor 16 1.18e-01 2.40e-01 0.29900 0.128000 -2.70e-01 3.75e-01 6.11e-02
APC truncation mutants have impaired AXIN binding 14 1.55e-01 2.90e-01 0.29800 0.023200 -2.97e-01 8.81e-01 5.40e-02
AXIN missense mutants destabilize the destruction complex 14 1.55e-01 2.90e-01 0.29800 0.023200 -2.97e-01 8.81e-01 5.40e-02
Signaling by AMER1 mutants 14 1.55e-01 2.90e-01 0.29800 0.023200 -2.97e-01 8.81e-01 5.40e-02
Signaling by APC mutants 14 1.55e-01 2.90e-01 0.29800 0.023200 -2.97e-01 8.81e-01 5.40e-02
Signaling by AXIN mutants 14 1.55e-01 2.90e-01 0.29800 0.023200 -2.97e-01 8.81e-01 5.40e-02
Truncations of AMER1 destabilize the destruction complex 14 1.55e-01 2.90e-01 0.29800 0.023200 -2.97e-01 8.81e-01 5.40e-02
Nucleotide salvage 21 6.07e-02 1.47e-01 0.29800 -0.040500 -2.95e-01 7.48e-01 1.92e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.19e-01 2.40e-01 0.29800 -0.025200 -2.97e-01 8.61e-01 3.99e-02
Defective B4GALT7 causes EDS, progeroid type 17 1.05e-01 2.21e-01 0.29800 0.021700 -2.97e-01 8.77e-01 3.42e-02
ECM proteoglycans 61 3.22e-04 1.72e-03 0.29700 0.004080 -2.97e-01 9.56e-01 6.07e-05
Extracellular matrix organization 250 6.33e-15 1.75e-13 0.29600 -0.089400 -2.83e-01 1.51e-02 1.48e-14
Activation of the AP-1 family of transcription factors 10 2.70e-01 4.31e-01 0.29600 0.278000 -1.04e-01 1.28e-01 5.71e-01
Metalloprotease DUBs 19 8.39e-02 1.88e-01 0.29600 0.182000 -2.34e-01 1.70e-01 7.77e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.67e-01 4.28e-01 0.29600 0.129000 2.66e-01 4.80e-01 1.45e-01
Sema4D induced cell migration and growth-cone collapse 19 8.52e-02 1.90e-01 0.29500 0.256000 -1.47e-01 5.35e-02 2.66e-01
FRS-mediated FGFR3 signaling 14 1.63e-01 3.04e-01 0.29500 0.169000 -2.42e-01 2.75e-01 1.17e-01
LGI-ADAM interactions 10 2.74e-01 4.35e-01 0.29400 -0.291000 4.49e-02 1.11e-01 8.06e-01
Apoptotic cleavage of cellular proteins 34 1.18e-02 3.98e-02 0.29400 0.225000 1.90e-01 2.35e-02 5.52e-02
Signaling by Insulin receptor 65 2.15e-04 1.19e-03 0.29400 -0.141000 -2.57e-01 4.88e-02 3.33e-04
MAPK6/MAPK4 signaling 83 2.42e-05 1.58e-04 0.29400 0.092000 -2.79e-01 1.48e-01 1.13e-05
Azathioprine ADME 18 9.58e-02 2.06e-01 0.29400 -0.235000 -1.76e-01 8.45e-02 1.96e-01
Paracetamol ADME 19 8.89e-02 1.95e-01 0.29300 -0.233000 1.78e-01 7.91e-02 1.80e-01
RHO GTPases activate CIT 18 9.98e-02 2.12e-01 0.29300 0.291000 -2.67e-02 3.24e-02 8.45e-01
Carboxyterminal post-translational modifications of tubulin 30 2.26e-02 6.92e-02 0.29200 0.163000 -2.42e-01 1.23e-01 2.19e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes 14 1.69e-01 3.11e-01 0.29200 0.083800 -2.79e-01 5.87e-01 7.04e-02
Hedgehog ‘off’ state 105 1.74e-06 1.54e-05 0.29200 0.065000 -2.84e-01 2.50e-01 4.91e-07
Negative regulation of NMDA receptor-mediated neuronal transmission 16 1.31e-01 2.56e-01 0.29100 0.056000 -2.86e-01 6.98e-01 4.77e-02
Regulation of FZD by ubiquitination 16 1.33e-01 2.58e-01 0.29100 0.237000 -1.70e-01 1.01e-01 2.40e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 1.18e-01 2.40e-01 0.29000 0.025500 -2.89e-01 8.56e-01 3.93e-02
Defective B3GAT3 causes JDSSDHD 17 1.18e-01 2.40e-01 0.29000 0.034200 -2.88e-01 8.07e-01 4.00e-02
Hyaluronan uptake and degradation 11 2.50e-01 4.10e-01 0.28900 -0.266000 -1.12e-01 1.26e-01 5.19e-01
APC/C-mediated degradation of cell cycle proteins 84 2.78e-05 1.78e-04 0.28900 -0.028600 -2.88e-01 6.51e-01 5.26e-06
Regulation of mitotic cell cycle 84 2.78e-05 1.78e-04 0.28900 -0.028600 -2.88e-01 6.51e-01 5.26e-06
Citric acid cycle (TCA cycle) 22 6.34e-02 1.52e-01 0.28800 -0.214000 -1.93e-01 8.29e-02 1.17e-01
Uptake and actions of bacterial toxins 25 4.40e-02 1.16e-01 0.28800 -0.102000 -2.69e-01 3.76e-01 1.98e-02
UCH proteinases 85 2.71e-05 1.75e-04 0.28800 -0.000648 -2.88e-01 9.92e-01 4.51e-06
Formation of paraxial mesoderm 62 4.73e-04 2.42e-03 0.28700 -0.011000 -2.87e-01 8.81e-01 9.27e-05
Cellular response to chemical stress 183 1.79e-10 3.87e-09 0.28700 -0.049600 -2.83e-01 2.48e-01 4.45e-11
Purine catabolism 13 2.05e-01 3.54e-01 0.28600 0.164000 -2.35e-01 3.07e-01 1.42e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 9.67e-02 2.07e-01 0.28500 0.117000 2.61e-01 3.79e-01 4.93e-02
Repression of WNT target genes 14 1.84e-01 3.27e-01 0.28500 0.230000 -1.69e-01 1.36e-01 2.75e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.65e-01 4.26e-01 0.28500 0.170000 -2.29e-01 3.30e-01 1.88e-01
RHO GTPases Activate ROCKs 18 1.15e-01 2.38e-01 0.28300 0.278000 -5.41e-02 4.10e-02 6.91e-01
DNA Replication Pre-Initiation 102 5.30e-06 4.10e-05 0.28300 0.081400 -2.71e-01 1.56e-01 2.22e-06
The citric acid (TCA) cycle and respiratory electron transport 160 6.24e-09 1.02e-07 0.28200 0.030200 -2.80e-01 5.11e-01 9.52e-10
Acyl chain remodelling of PE 17 1.35e-01 2.60e-01 0.28200 -0.187000 2.11e-01 1.83e-01 1.32e-01
DAP12 interactions 35 1.57e-02 5.08e-02 0.28100 -0.278000 -4.09e-02 4.39e-03 6.75e-01
Antigen processing-Cross presentation 92 1.90e-05 1.26e-04 0.28000 -0.170000 -2.23e-01 4.83e-03 2.25e-04
Regulation of mRNA stability by proteins that bind AU-rich elements 87 3.90e-05 2.38e-04 0.28000 0.029800 -2.78e-01 6.31e-01 7.30e-06
Signaling by FGFR2 in disease 34 1.94e-02 6.17e-02 0.27900 0.161000 -2.29e-01 1.05e-01 2.11e-02
IRAK2 mediated activation of TAK1 complex 10 3.12e-01 4.70e-01 0.27900 0.080900 -2.67e-01 6.58e-01 1.43e-01
Non-integrin membrane-ECM interactions 54 1.90e-03 8.36e-03 0.27900 0.060300 -2.72e-01 4.43e-01 5.35e-04
Aspirin ADME 14 1.94e-01 3.41e-01 0.27900 -0.274000 -5.10e-02 7.56e-02 7.41e-01
Receptor Mediated Mitophagy 11 2.75e-01 4.35e-01 0.27900 -0.158000 -2.30e-01 3.65e-01 1.87e-01
Regulation of PTEN mRNA translation 11 2.75e-01 4.35e-01 0.27900 0.198000 1.96e-01 2.56e-01 2.60e-01
Germ layer formation at gastrulation 10 3.14e-01 4.71e-01 0.27900 0.268000 -7.56e-02 1.42e-01 6.79e-01
Mismatch Repair 14 1.99e-01 3.46e-01 0.27900 0.149000 -2.35e-01 3.35e-01 1.27e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 7.08e-02 1.64e-01 0.27800 0.218000 -1.73e-01 7.05e-02 1.50e-01
Formation of the cornified envelope 23 6.77e-02 1.58e-01 0.27800 -0.180000 -2.12e-01 1.35e-01 7.83e-02
Keratinization 23 6.77e-02 1.58e-01 0.27800 -0.180000 -2.12e-01 1.35e-01 7.83e-02
Insulin processing 21 8.62e-02 1.91e-01 0.27800 -0.256000 -1.09e-01 4.24e-02 3.86e-01
Cellular responses to stimuli 702 1.37e-34 9.61e-33 0.27800 0.069900 -2.69e-01 1.71e-03 9.16e-34
Interferon gamma signaling 74 1.95e-04 1.09e-03 0.27800 -0.278000 7.48e-03 3.59e-05 9.11e-01
Diseases associated with the TLR signaling cascade 27 4.43e-02 1.16e-01 0.27800 -0.277000 2.12e-02 1.27e-02 8.49e-01
Diseases of Immune System 27 4.43e-02 1.16e-01 0.27800 -0.277000 2.12e-02 1.27e-02 8.49e-01
Initiation of Nuclear Envelope (NE) Reformation 19 1.13e-01 2.34e-01 0.27800 0.121000 -2.50e-01 3.61e-01 5.92e-02
Cytochrome c-mediated apoptotic response 13 2.25e-01 3.81e-01 0.27700 -0.120000 2.50e-01 4.53e-01 1.18e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 2.27e-01 3.83e-01 0.27700 0.191000 -2.01e-01 2.34e-01 2.09e-01
Peptide ligand-binding receptors 79 1.17e-04 6.62e-04 0.27700 -0.053900 -2.71e-01 4.08e-01 3.09e-05
Interferon alpha/beta signaling 57 1.42e-03 6.48e-03 0.27600 -0.253000 -1.12e-01 9.74e-04 1.43e-01
FRS-mediated FGFR2 signaling 16 1.64e-01 3.04e-01 0.27600 0.161000 -2.24e-01 2.64e-01 1.21e-01
Pre-NOTCH Processing in Golgi 18 1.26e-01 2.50e-01 0.27600 -0.202000 -1.88e-01 1.39e-01 1.67e-01
Regulation of TP53 Expression and Degradation 36 1.69e-02 5.42e-02 0.27500 -0.008350 -2.75e-01 9.31e-01 4.30e-03
Translesion synthesis by REV1 16 1.68e-01 3.09e-01 0.27400 0.175000 -2.11e-01 2.25e-01 1.44e-01
TNFR1-induced NF-kappa-B signaling pathway 33 2.37e-02 7.13e-02 0.27400 -0.190000 -1.98e-01 5.92e-02 4.96e-02
Neutrophil degranulation 423 4.48e-21 1.78e-19 0.27400 -0.188000 -1.99e-01 3.84e-11 2.51e-12
Biosynthesis of specialized proresolving mediators (SPMs) 13 2.35e-01 3.93e-01 0.27400 -0.255000 9.97e-02 1.12e-01 5.34e-01
ERKs are inactivated 13 2.34e-01 3.92e-01 0.27300 -0.029300 -2.71e-01 8.55e-01 9.04e-02
RORA activates gene expression 18 1.37e-01 2.63e-01 0.27300 -0.137000 2.36e-01 3.15e-01 8.31e-02
Apoptotic execution phase 42 8.96e-03 3.16e-02 0.27300 0.211000 1.72e-01 1.79e-02 5.33e-02
Cellular responses to stress 693 7.77e-33 4.96e-31 0.27200 0.071800 -2.63e-01 1.34e-03 6.67e-32
Signaling by FGFR4 in disease 10 3.27e-01 4.82e-01 0.27200 0.131000 2.38e-01 4.73e-01 1.92e-01
Attachment and Entry 9694614 16 1.68e-01 3.09e-01 0.27200 -0.157000 -2.22e-01 2.78e-01 1.24e-01
Gap junction trafficking 32 2.89e-02 8.35e-02 0.27200 -0.045600 -2.68e-01 6.55e-01 8.79e-03
Telomere Extension By Telomerase 21 9.91e-02 2.11e-01 0.27100 0.044900 -2.68e-01 7.22e-01 3.37e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 2.95e-01 4.57e-01 0.27100 -0.177000 -2.05e-01 3.10e-01 2.38e-01
Cardiogenesis 18 1.39e-01 2.67e-01 0.27100 0.267000 -4.67e-02 4.99e-02 7.32e-01
Spry regulation of FGF signaling 16 1.73e-01 3.13e-01 0.27100 0.021500 -2.70e-01 8.82e-01 6.15e-02
Signaling by CSF3 (G-CSF) 29 4.12e-02 1.10e-01 0.27100 -0.051700 -2.66e-01 6.30e-01 1.33e-02
Cyclin D associated events in G1 47 5.85e-03 2.17e-02 0.27000 -0.016400 -2.70e-01 8.46e-01 1.38e-03
G1 Phase 47 5.85e-03 2.17e-02 0.27000 -0.016400 -2.70e-01 8.46e-01 1.38e-03
RNA Polymerase III Chain Elongation 18 1.43e-01 2.72e-01 0.27000 0.167000 -2.12e-01 2.20e-01 1.19e-01
Fcgamma receptor (FCGR) dependent phagocytosis 90 5.43e-05 3.24e-04 0.26900 -0.240000 -1.23e-01 8.41e-05 4.46e-02
Signaling by PDGFRA extracellular domain mutants 12 2.68e-01 4.29e-01 0.26900 -0.166000 -2.12e-01 3.20e-01 2.03e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.68e-01 4.29e-01 0.26900 -0.166000 -2.12e-01 3.20e-01 2.03e-01
Platelet Adhesion to exposed collagen 11 3.05e-01 4.66e-01 0.26900 0.033500 -2.67e-01 8.47e-01 1.26e-01
Metabolism of folate and pterines 16 1.74e-01 3.16e-01 0.26900 -0.207000 -1.71e-01 1.52e-01 2.35e-01
Regulation of actin dynamics for phagocytic cup formation 67 6.86e-04 3.45e-03 0.26900 -0.236000 -1.29e-01 8.61e-04 6.71e-02
RIP-mediated NFkB activation via ZBP1 17 1.58e-01 2.94e-01 0.26800 -0.158000 -2.17e-01 2.59e-01 1.22e-01
Mitotic G1 phase and G1/S transition 143 2.49e-07 2.65e-06 0.26700 -0.013100 -2.67e-01 7.86e-01 3.68e-08
AKT phosphorylates targets in the nucleus 10 3.44e-01 4.99e-01 0.26700 0.013300 -2.67e-01 9.42e-01 1.44e-01
Alpha-protein kinase 1 signaling pathway 11 3.11e-01 4.70e-01 0.26700 0.072500 -2.57e-01 6.77e-01 1.40e-01
Blood group systems biosynthesis 13 2.55e-01 4.15e-01 0.26600 0.210000 -1.63e-01 1.90e-01 3.08e-01
EPH-ephrin mediated repulsion of cells 44 9.52e-03 3.31e-02 0.26500 -0.261000 -4.97e-02 2.77e-03 5.68e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 2.83e-01 4.46e-01 0.26500 -0.057400 2.59e-01 7.31e-01 1.20e-01
Chaperonin-mediated protein folding 77 3.29e-04 1.75e-03 0.26500 0.120000 -2.36e-01 6.90e-02 3.38e-04
Nuclear events stimulated by ALK signaling in cancer 18 1.50e-01 2.83e-01 0.26500 -0.040400 -2.62e-01 7.67e-01 5.45e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 1.28e-02 4.22e-02 0.26400 0.095200 -2.46e-01 2.86e-01 5.75e-03
HIV Transcription Elongation 42 1.28e-02 4.22e-02 0.26400 0.095200 -2.46e-01 2.86e-01 5.75e-03
Tat-mediated elongation of the HIV-1 transcript 42 1.28e-02 4.22e-02 0.26400 0.095200 -2.46e-01 2.86e-01 5.75e-03
Nuclear Events (kinase and transcription factor activation) 57 2.84e-03 1.18e-02 0.26300 0.148000 -2.18e-01 5.30e-02 4.48e-03
ABC-family proteins mediated transport 90 8.69e-05 5.06e-04 0.26300 -0.101000 -2.43e-01 9.89e-02 6.83e-05
Nucleotide biosynthesis 12 2.85e-01 4.49e-01 0.26300 -0.144000 -2.20e-01 3.89e-01 1.86e-01
CD28 dependent PI3K/Akt signaling 21 1.13e-01 2.33e-01 0.26300 -0.252000 -7.44e-02 4.55e-02 5.55e-01
Nucleotide-like (purinergic) receptors 15 2.13e-01 3.65e-01 0.26200 0.030600 2.60e-01 8.37e-01 8.10e-02
Pyruvate metabolism 27 6.23e-02 1.50e-01 0.26100 -0.139000 -2.21e-01 2.11e-01 4.72e-02
Intra-Golgi traffic 41 1.50e-02 4.89e-02 0.26100 -0.250000 -7.40e-02 5.57e-03 4.13e-01
Interleukin-1 family signaling 137 9.63e-07 9.01e-06 0.26000 -0.028000 -2.59e-01 5.72e-01 1.71e-07
Signaling by FGFR3 in disease 16 2.00e-01 3.47e-01 0.26000 0.216000 -1.45e-01 1.35e-01 3.15e-01
Signaling by the B Cell Receptor (BCR) 109 1.61e-05 1.08e-04 0.26000 -0.038700 -2.57e-01 4.86e-01 3.49e-06
CD28 co-stimulation 32 3.92e-02 1.05e-01 0.25900 -0.250000 -7.05e-02 1.45e-02 4.90e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 32 3.96e-02 1.06e-01 0.25900 -0.253000 -5.68e-02 1.34e-02 5.78e-01
Glycogen metabolism 23 1.04e-01 2.19e-01 0.25800 0.148000 -2.11e-01 2.19e-01 8.03e-02
Cytosolic iron-sulfur cluster assembly 13 2.75e-01 4.35e-01 0.25700 -0.257000 -6.93e-03 1.08e-01 9.66e-01
Regulation of TP53 Degradation 35 3.12e-02 8.89e-02 0.25700 -0.012500 -2.57e-01 8.99e-01 8.56e-03
Gap junction trafficking and regulation 34 3.43e-02 9.51e-02 0.25700 -0.037800 -2.54e-01 7.03e-01 1.03e-02
Peptide hormone metabolism 51 6.37e-03 2.34e-02 0.25700 -0.092600 -2.39e-01 2.53e-01 3.11e-03
Signaling by Interleukins 388 5.09e-17 1.46e-15 0.25600 -0.085600 -2.41e-01 3.92e-03 3.97e-16
Interleukin-12 family signaling 47 9.79e-03 3.38e-02 0.25600 -0.095800 -2.37e-01 2.56e-01 4.93e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 2.53e-01 4.12e-01 0.25600 0.048200 2.51e-01 7.55e-01 1.04e-01
Regulation of TNFR1 signaling 48 8.94e-03 3.16e-02 0.25500 -0.156000 -2.02e-01 6.08e-02 1.57e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 2.08e-01 3.58e-01 0.25500 0.110000 2.30e-01 4.44e-01 1.11e-01
Sema4D in semaphorin signaling 23 1.09e-01 2.27e-01 0.25400 0.241000 -8.13e-02 4.54e-02 5.00e-01
Condensation of Prometaphase Chromosomes 11 3.42e-01 4.98e-01 0.25400 -0.213000 -1.39e-01 2.22e-01 4.24e-01
Molecules associated with elastic fibres 33 4.05e-02 1.08e-01 0.25400 -0.106000 -2.31e-01 2.94e-01 2.17e-02
Disorders of Developmental Biology 11 3.49e-01 5.04e-01 0.25200 -0.192000 -1.63e-01 2.70e-01 3.50e-01
Disorders of Nervous System Development 11 3.49e-01 5.04e-01 0.25200 -0.192000 -1.63e-01 2.70e-01 3.50e-01
Loss of function of MECP2 in Rett syndrome 11 3.49e-01 5.04e-01 0.25200 -0.192000 -1.63e-01 2.70e-01 3.50e-01
Pervasive developmental disorders 11 3.49e-01 5.04e-01 0.25200 -0.192000 -1.63e-01 2.70e-01 3.50e-01
Platelet sensitization by LDL 17 1.98e-01 3.45e-01 0.25100 -0.103000 -2.29e-01 4.63e-01 1.01e-01
Formation of RNA Pol II elongation complex 56 5.24e-03 1.98e-02 0.25100 0.090500 -2.34e-01 2.42e-01 2.43e-03
RNA Polymerase II Transcription Elongation 56 5.24e-03 1.98e-02 0.25100 0.090500 -2.34e-01 2.42e-01 2.43e-03
MHC class II antigen presentation 97 1.02e-04 5.85e-04 0.25100 -0.145000 -2.05e-01 1.39e-02 4.86e-04
FCERI mediated Ca+2 mobilization 35 3.62e-02 9.94e-02 0.25100 -0.229000 -1.01e-01 1.89e-02 2.99e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 2.98e-01 4.60e-01 0.25100 0.146000 -2.03e-01 3.61e-01 2.04e-01
Platelet degranulation 110 3.13e-05 1.97e-04 0.25100 -0.129000 -2.15e-01 1.93e-02 1.02e-04
G1/S Transition 125 8.50e-06 6.06e-05 0.25000 0.001500 -2.50e-01 9.77e-01 1.35e-06
Signaling by CSF1 (M-CSF) in myeloid cells 31 5.41e-02 1.33e-01 0.25000 -0.239000 -7.48e-02 2.15e-02 4.71e-01
RAF-independent MAPK1/3 activation 22 1.30e-01 2.54e-01 0.25000 0.153000 -1.98e-01 2.15e-01 1.08e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 5.86e-03 2.17e-02 0.24900 -0.241000 -6.49e-02 2.01e-03 4.05e-01
CASP8 activity is inhibited 10 3.95e-01 5.51e-01 0.24900 -0.012200 -2.48e-01 9.47e-01 1.74e-01
Dimerization of procaspase-8 10 3.95e-01 5.51e-01 0.24900 -0.012200 -2.48e-01 9.47e-01 1.74e-01
Regulation by c-FLIP 10 3.95e-01 5.51e-01 0.24900 -0.012200 -2.48e-01 9.47e-01 1.74e-01
FCGR3A-mediated phagocytosis 65 2.40e-03 1.02e-02 0.24900 -0.234000 -8.27e-02 1.09e-03 2.49e-01
Leishmania phagocytosis 65 2.40e-03 1.02e-02 0.24900 -0.234000 -8.27e-02 1.09e-03 2.49e-01
Parasite infection 65 2.40e-03 1.02e-02 0.24900 -0.234000 -8.27e-02 1.09e-03 2.49e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 2.50e-01 4.10e-01 0.24800 0.248000 -1.69e-04 9.60e-02 9.99e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 2.50e-01 4.10e-01 0.24800 0.248000 -1.69e-04 9.60e-02 9.99e-01
GABA synthesis, release, reuptake and degradation 13 3.02e-01 4.64e-01 0.24800 -0.007960 -2.48e-01 9.60e-01 1.22e-01
Anti-inflammatory response favouring Leishmania parasite infection 74 1.07e-03 5.16e-03 0.24800 -0.227000 -9.92e-02 7.32e-04 1.40e-01
Leishmania parasite growth and survival 74 1.07e-03 5.16e-03 0.24800 -0.227000 -9.92e-02 7.32e-04 1.40e-01
Biosynthesis of DHA-derived SPMs 11 3.68e-01 5.22e-01 0.24700 -0.206000 1.37e-01 2.37e-01 4.32e-01
Gastrulation 85 4.64e-04 2.39e-03 0.24600 0.060800 -2.39e-01 3.33e-01 1.42e-04
Platelet calcium homeostasis 22 1.34e-01 2.59e-01 0.24600 -0.091800 -2.28e-01 4.56e-01 6.37e-02
Smooth Muscle Contraction 37 3.58e-02 9.85e-02 0.24600 0.217000 -1.16e-01 2.23e-02 2.23e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 4.58e-02 1.18e-01 0.24600 -0.022000 -2.45e-01 8.24e-01 1.35e-02
Nervous system development 506 6.26e-20 2.36e-18 0.24600 0.117000 -2.16e-01 7.16e-06 1.05e-16
Diseases of carbohydrate metabolism 28 7.79e-02 1.77e-01 0.24600 -0.158000 -1.88e-01 1.47e-01 8.56e-02
NOTCH2 intracellular domain regulates transcription 10 4.08e-01 5.62e-01 0.24600 -0.219000 1.12e-01 2.31e-01 5.41e-01
Fc epsilon receptor (FCERI) signaling 131 7.68e-06 5.64e-05 0.24500 -0.068600 -2.35e-01 1.76e-01 3.35e-06
Protein folding 83 6.57e-04 3.32e-03 0.24400 0.110000 -2.18e-01 8.42e-02 6.00e-04
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 2.86e-01 4.49e-01 0.24400 -0.061400 -2.36e-01 6.91e-01 1.27e-01
Defective EXT2 causes exostoses 2 14 2.86e-01 4.49e-01 0.24400 -0.061400 -2.36e-01 6.91e-01 1.27e-01
Formation of the Early Elongation Complex 33 5.44e-02 1.33e-01 0.24400 0.091300 -2.26e-01 3.64e-01 2.48e-02
Formation of the HIV-1 Early Elongation Complex 33 5.44e-02 1.33e-01 0.24400 0.091300 -2.26e-01 3.64e-01 2.48e-02
Activation of BAD and translocation to mitochondria 15 2.67e-01 4.28e-01 0.24300 0.124000 -2.09e-01 4.05e-01 1.61e-01
Axon guidance 486 8.66e-19 2.89e-17 0.24300 0.111000 -2.16e-01 2.95e-05 3.92e-16
Integrin signaling 23 1.30e-01 2.54e-01 0.24300 -0.234000 -6.56e-02 5.21e-02 5.86e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 9.42e-02 2.03e-01 0.24300 0.104000 -2.19e-01 3.52e-01 4.85e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 9.42e-02 2.03e-01 0.24300 0.104000 -2.19e-01 3.52e-01 4.85e-02
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 2.21e-01 3.75e-01 0.24200 -0.152000 -1.88e-01 2.77e-01 1.79e-01
p75NTR recruits signalling complexes 13 3.20e-01 4.74e-01 0.24200 0.030500 -2.40e-01 8.49e-01 1.34e-01
Bacterial Infection Pathways 65 3.33e-03 1.36e-02 0.24100 -0.122000 -2.09e-01 9.03e-02 3.65e-03
IRAK1 recruits IKK complex 14 2.98e-01 4.60e-01 0.24100 0.217000 -1.05e-01 1.59e-01 4.97e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 2.98e-01 4.60e-01 0.24100 0.217000 -1.05e-01 1.59e-01 4.97e-01
Response to elevated platelet cytosolic Ca2+ 114 4.75e-05 2.88e-04 0.24100 -0.124000 -2.07e-01 2.27e-02 1.36e-04
Signaling by FGFR3 34 5.29e-02 1.32e-01 0.24100 0.098300 -2.20e-01 3.22e-01 2.63e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 2.68e-01 4.29e-01 0.24100 -0.190000 -1.47e-01 2.02e-01 3.23e-01
Transcriptional regulation by RUNX1 164 7.71e-07 7.55e-06 0.24100 0.059000 -2.33e-01 1.93e-01 2.54e-07
Heparan sulfate/heparin (HS-GAG) metabolism 43 2.34e-02 7.09e-02 0.24000 -0.176000 -1.64e-01 4.60e-02 6.30e-02
The phototransduction cascade 19 1.96e-01 3.43e-01 0.24000 0.197000 -1.37e-01 1.37e-01 3.00e-01
HS-GAG degradation 22 1.50e-01 2.83e-01 0.24000 -0.240000 1.60e-02 5.17e-02 8.97e-01
Signaling by NOTCH4 81 9.55e-04 4.68e-03 0.24000 0.034800 -2.38e-01 5.88e-01 2.20e-04
Innate Immune System 870 4.42e-32 2.50e-30 0.24000 -0.180000 -1.59e-01 2.94e-19 2.92e-15
TAK1-dependent IKK and NF-kappa-B activation 43 2.45e-02 7.30e-02 0.23900 -0.090200 -2.22e-01 3.06e-01 1.19e-02
Metabolism of nucleotides 81 9.83e-04 4.80e-03 0.23900 -0.008120 -2.39e-01 9.00e-01 2.01e-04
Synthesis of PIPs at the late endosome membrane 11 3.94e-01 5.51e-01 0.23800 -0.115000 2.09e-01 5.09e-01 2.30e-01
Translesion synthesis by POLI 17 2.38e-01 3.95e-01 0.23800 0.193000 -1.40e-01 1.69e-01 3.16e-01
Translesion synthesis by POLK 17 2.39e-01 3.96e-01 0.23800 0.169000 -1.68e-01 2.28e-01 2.31e-01
Detoxification of Reactive Oxygen Species 33 6.12e-02 1.48e-01 0.23700 -0.068000 -2.27e-01 4.99e-01 2.39e-02
Nuclear Pore Complex (NPC) Disassembly 36 4.99e-02 1.27e-01 0.23700 -0.189000 1.43e-01 4.95e-02 1.39e-01
Inactivation, recovery and regulation of the phototransduction cascade 18 2.24e-01 3.79e-01 0.23600 0.198000 -1.29e-01 1.46e-01 3.42e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 72 2.36e-03 1.01e-02 0.23600 -0.128000 -1.99e-01 6.11e-02 3.57e-03
Signaling by Hedgehog 139 9.90e-06 6.93e-05 0.23600 0.014000 -2.36e-01 7.76e-01 1.63e-06
Glutamate binding, activation of AMPA receptors and synaptic plasticity 24 1.32e-01 2.57e-01 0.23600 -0.181000 -1.52e-01 1.26e-01 1.97e-01
Trafficking of AMPA receptors 24 1.32e-01 2.57e-01 0.23600 -0.181000 -1.52e-01 1.26e-01 1.97e-01
RHOBTB GTPase Cycle 35 5.35e-02 1.32e-01 0.23600 0.210000 1.08e-01 3.20e-02 2.71e-01
Signaling by FGFR4 32 7.18e-02 1.65e-01 0.23500 0.121000 -2.02e-01 2.35e-01 4.84e-02
SHC-mediated cascade:FGFR1 13 3.42e-01 4.98e-01 0.23500 0.061000 -2.27e-01 7.03e-01 1.56e-01
Signaling by Activin 13 3.41e-01 4.97e-01 0.23500 0.235000 -4.59e-03 1.42e-01 9.77e-01
Early Phase of HIV Life Cycle 14 3.12e-01 4.70e-01 0.23500 -0.229000 -5.12e-02 1.37e-01 7.40e-01
RNA Polymerase II Pre-transcription Events 77 1.84e-03 8.12e-03 0.23500 0.113000 -2.06e-01 8.71e-02 1.78e-03
PIWI-interacting RNA (piRNA) biogenesis 22 1.64e-01 3.04e-01 0.23500 0.077800 -2.22e-01 5.28e-01 7.20e-02
Regulation of TP53 Activity through Acetylation 29 9.12e-02 1.99e-01 0.23400 -0.074200 -2.22e-01 4.89e-01 3.84e-02
PI-3K cascade:FGFR1 13 3.44e-01 5.00e-01 0.23400 0.233000 -1.98e-02 1.45e-01 9.02e-01
HS-GAG biosynthesis 23 1.52e-01 2.86e-01 0.23400 -0.019700 -2.33e-01 8.70e-01 5.31e-02
Kinesins 46 2.35e-02 7.09e-02 0.23400 0.026900 -2.32e-01 7.53e-01 6.46e-03
NS1 Mediated Effects on Host Pathways 40 3.97e-02 1.06e-01 0.23300 -0.124000 1.97e-01 1.74e-01 3.09e-02
Leading Strand Synthesis 14 3.19e-01 4.74e-01 0.23300 0.032200 2.31e-01 8.35e-01 1.35e-01
Polymerase switching 14 3.19e-01 4.74e-01 0.23300 0.032200 2.31e-01 8.35e-01 1.35e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 22 1.72e-01 3.13e-01 0.23200 0.152000 -1.76e-01 2.17e-01 1.54e-01
DNA Replication 127 3.95e-05 2.41e-04 0.23200 0.052300 -2.26e-01 3.09e-01 1.10e-05
Diseases of glycosylation 127 3.58e-05 2.22e-04 0.23200 -0.128000 -1.93e-01 1.29e-02 1.71e-04
ZBP1(DAI) mediated induction of type I IFNs 20 1.98e-01 3.45e-01 0.23200 -0.165000 -1.63e-01 2.02e-01 2.08e-01
Synthesis of substrates in N-glycan biosythesis 57 1.01e-02 3.46e-02 0.23100 -0.110000 -2.04e-01 1.50e-01 7.88e-03
Intraflagellar transport 49 2.00e-02 6.25e-02 0.23100 0.228000 -3.73e-02 5.69e-03 6.51e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 7.87e-02 1.78e-01 0.23100 -0.158000 1.69e-01 1.23e-01 9.72e-02
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 4.19e-01 5.72e-01 0.23100 0.145000 -1.80e-01 4.06e-01 3.02e-01
Synthesis of DNA 116 1.08e-04 6.13e-04 0.23000 0.042000 -2.26e-01 4.35e-01 2.56e-05
Formation of HIV elongation complex in the absence of HIV Tat 44 3.13e-02 8.90e-02 0.23000 0.087500 -2.13e-01 3.16e-01 1.46e-02
Uptake and function of anthrax toxins 11 4.17e-01 5.70e-01 0.23000 -0.037100 -2.27e-01 8.31e-01 1.92e-01
Autophagy 138 2.12e-05 1.40e-04 0.23000 0.120000 -1.96e-01 1.48e-02 7.21e-05
Signaling by FGFR2 61 8.45e-03 3.00e-02 0.23000 0.098500 -2.07e-01 1.83e-01 5.10e-03
DAP12 signaling 27 1.20e-01 2.41e-01 0.22900 -0.222000 5.70e-02 4.58e-02 6.08e-01
Regulation of IFNG signaling 13 3.56e-01 5.11e-01 0.22900 -0.136000 -1.84e-01 3.96e-01 2.50e-01
Association of TriC/CCT with target proteins during biosynthesis 35 6.46e-02 1.54e-01 0.22900 0.056800 -2.22e-01 5.61e-01 2.31e-02
Surfactant metabolism 18 2.41e-01 3.98e-01 0.22900 0.071300 2.18e-01 6.00e-01 1.10e-01
VEGFR2 mediated cell proliferation 19 2.25e-01 3.80e-01 0.22800 -0.069900 -2.17e-01 5.98e-01 1.01e-01
MET activates PTK2 signaling 30 9.60e-02 2.06e-01 0.22800 -0.036200 -2.25e-01 7.31e-01 3.28e-02
Metabolic disorders of biological oxidation enzymes 23 1.64e-01 3.04e-01 0.22800 -0.122000 -1.93e-01 3.12e-01 1.10e-01
Processive synthesis on the C-strand of the telomere 19 2.31e-01 3.89e-01 0.22800 0.113000 -1.98e-01 3.94e-01 1.36e-01
RA biosynthesis pathway 15 3.10e-01 4.70e-01 0.22800 0.062600 2.19e-01 6.74e-01 1.42e-01
RHOBTB2 GTPase cycle 23 1.69e-01 3.10e-01 0.22800 0.224000 -4.14e-02 6.32e-02 7.31e-01
p38MAPK events 13 3.61e-01 5.16e-01 0.22800 -0.172000 -1.49e-01 2.82e-01 3.53e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 3.64e-01 5.17e-01 0.22700 -0.057200 -2.20e-01 7.21e-01 1.70e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.30e-01 5.84e-01 0.22700 -0.176000 1.44e-01 3.12e-01 4.10e-01
SARS-CoV-1 Infection 136 3.21e-05 2.01e-04 0.22700 0.124000 -1.90e-01 1.27e-02 1.30e-04
HIV Transcription Initiation 45 3.22e-02 9.06e-02 0.22700 0.151000 -1.70e-01 8.04e-02 4.90e-02
RNA Polymerase II HIV Promoter Escape 45 3.22e-02 9.06e-02 0.22700 0.151000 -1.70e-01 8.04e-02 4.90e-02
RNA Polymerase II Promoter Escape 45 3.22e-02 9.06e-02 0.22700 0.151000 -1.70e-01 8.04e-02 4.90e-02
RNA Polymerase II Transcription Initiation 45 3.22e-02 9.06e-02 0.22700 0.151000 -1.70e-01 8.04e-02 4.90e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 3.22e-02 9.06e-02 0.22700 0.151000 -1.70e-01 8.04e-02 4.90e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 3.22e-02 9.06e-02 0.22700 0.151000 -1.70e-01 8.04e-02 4.90e-02
The NLRP3 inflammasome 16 2.90e-01 4.53e-01 0.22600 -0.154000 -1.66e-01 2.86e-01 2.52e-01
Signaling by PDGF 53 1.75e-02 5.60e-02 0.22500 -0.139000 -1.77e-01 8.03e-02 2.59e-02
Nuclear Envelope (NE) Reassembly 68 6.03e-03 2.23e-02 0.22500 0.074900 -2.12e-01 2.86e-01 2.50e-03
Incretin synthesis, secretion, and inactivation 12 4.04e-01 5.58e-01 0.22500 0.049200 -2.19e-01 7.68e-01 1.88e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 12 4.04e-01 5.58e-01 0.22500 0.049200 -2.19e-01 7.68e-01 1.88e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 4.71e-01 6.20e-01 0.22400 0.224000 1.40e-02 2.21e-01 9.39e-01
PTEN Regulation 137 3.82e-05 2.35e-04 0.22400 0.048400 -2.18e-01 3.28e-01 1.02e-05
NRIF signals cell death from the nucleus 16 3.04e-01 4.65e-01 0.22400 0.103000 -1.99e-01 4.77e-01 1.69e-01
G2/M Checkpoints 124 1.00e-04 5.79e-04 0.22400 0.030900 -2.21e-01 5.53e-01 2.08e-05
Interleukin-3, Interleukin-5 and GM-CSF signaling 43 4.19e-02 1.11e-01 0.22200 -0.222000 7.98e-04 1.18e-02 9.93e-01
PECAM1 interactions 12 4.12e-01 5.66e-01 0.22200 -0.220000 -2.69e-02 1.87e-01 8.72e-01
FGFR2 alternative splicing 24 1.72e-01 3.13e-01 0.22200 0.056100 -2.15e-01 6.34e-01 6.88e-02
Transport of the SLBP independent Mature mRNA 35 7.79e-02 1.77e-01 0.22200 -0.138000 1.74e-01 1.58e-01 7.55e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 4.74e-02 1.21e-01 0.22100 -0.145000 1.67e-01 1.04e-01 6.12e-02
Downstream signaling of activated FGFR4 18 2.71e-01 4.31e-01 0.22100 0.182000 -1.25e-01 1.80e-01 3.60e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 42 4.68e-02 1.20e-01 0.22100 0.019800 -2.20e-01 8.25e-01 1.36e-02
Host Interactions of HIV factors 127 9.27e-05 5.38e-04 0.22100 -0.098400 -1.98e-01 5.56e-02 1.21e-04
DNA Double Strand Break Response 43 4.40e-02 1.16e-01 0.22100 0.024700 -2.19e-01 7.80e-01 1.29e-02
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 1.03e-01 2.18e-01 0.21900 0.141000 -1.68e-01 1.68e-01 1.01e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.55e-01 2.90e-01 0.21800 -0.032600 -2.16e-01 7.73e-01 5.67e-02
MyD88 deficiency (TLR2/4) 14 3.70e-01 5.24e-01 0.21800 -0.216000 3.04e-02 1.62e-01 8.44e-01
C-type lectin receptors (CLRs) 122 1.74e-04 9.74e-04 0.21800 -0.070000 -2.06e-01 1.82e-01 8.56e-05
trans-Golgi Network Vesicle Budding 70 7.00e-03 2.55e-02 0.21700 -0.214000 -3.80e-02 1.96e-03 5.83e-01
Immune System 1632 1.35e-46 1.99e-44 0.21700 -0.163000 -1.44e-01 2.58e-27 1.13e-21
Regulation of gene expression by Hypoxia-inducible Factor 10 4.95e-01 6.41e-01 0.21700 0.045000 -2.12e-01 8.05e-01 2.45e-01
Receptor-type tyrosine-protein phosphatases 12 4.32e-01 5.85e-01 0.21700 0.108000 -1.88e-01 5.17e-01 2.60e-01
Erythropoietin activates RAS 13 3.99e-01 5.54e-01 0.21700 -0.214000 -3.66e-02 1.82e-01 8.19e-01
Transcription of the HIV genome 67 9.63e-03 3.34e-02 0.21600 0.103000 -1.90e-01 1.45e-01 7.17e-03
TGF-beta receptor signaling activates SMADs 45 4.50e-02 1.16e-01 0.21500 0.069600 -2.04e-01 4.19e-01 1.81e-02
Meiotic recombination 26 1.70e-01 3.11e-01 0.21400 0.140000 -1.63e-01 2.17e-01 1.51e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 2.94e-02 8.44e-02 0.21400 -0.148000 -1.55e-01 6.82e-02 5.55e-02
Macroautophagy 124 2.28e-04 1.25e-03 0.21400 0.122000 -1.76e-01 1.89e-02 7.34e-04
Intra-Golgi and retrograde Golgi-to-ER traffic 184 3.46e-06 2.85e-05 0.21400 -0.081300 -1.98e-01 5.75e-02 3.77e-06
TNF signaling 57 1.96e-02 6.18e-02 0.21400 -0.163000 -1.38e-01 3.31e-02 7.12e-02
IRAK4 deficiency (TLR2/4) 15 3.60e-01 5.15e-01 0.21400 -0.197000 8.36e-02 1.87e-01 5.75e-01
Downstream signaling of activated FGFR3 19 2.75e-01 4.35e-01 0.21400 0.139000 -1.62e-01 2.93e-01 2.21e-01
mRNA Capping 29 1.40e-01 2.68e-01 0.21400 0.106000 -1.86e-01 3.24e-01 8.37e-02
Mitochondrial tRNA aminoacylation 21 2.35e-01 3.93e-01 0.21400 -0.150000 -1.52e-01 2.34e-01 2.29e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 2.15e-02 6.66e-02 0.21300 -0.187000 -1.03e-01 1.56e-02 1.83e-01
FCERI mediated MAPK activation 36 8.50e-02 1.90e-01 0.21300 -0.205000 -5.78e-02 3.30e-02 5.49e-01
Separation of Sister Chromatids 175 8.30e-06 5.97e-05 0.21300 0.066300 -2.02e-01 1.31e-01 4.05e-06
G alpha (i) signalling events 178 5.80e-06 4.42e-05 0.21300 -0.122000 -1.74e-01 5.18e-03 6.04e-05
Negative regulation of FGFR1 signaling 25 1.86e-01 3.29e-01 0.21300 0.072900 -2.00e-01 5.28e-01 8.38e-02
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.17e-01 2.40e-01 0.21200 -0.128000 1.69e-01 2.09e-01 9.76e-02
Metabolism of fat-soluble vitamins 32 1.18e-01 2.40e-01 0.21200 0.068900 -2.00e-01 5.00e-01 4.98e-02
mRNA Splicing - Minor Pathway 50 3.57e-02 9.83e-02 0.21200 0.091900 -1.91e-01 2.61e-01 1.95e-02
Viral Infection Pathways 662 2.76e-19 9.66e-18 0.21200 0.039200 -2.08e-01 8.72e-02 9.07e-20
PERK regulates gene expression 32 1.18e-01 2.40e-01 0.21200 0.066600 -2.01e-01 5.15e-01 4.92e-02
Beta-oxidation of very long chain fatty acids 10 5.22e-01 6.64e-01 0.20900 -0.148000 1.48e-01 4.18e-01 4.17e-01
Mitotic G2-G2/M phases 187 5.69e-06 4.35e-05 0.20900 0.036100 -2.06e-01 3.95e-01 1.25e-06
G2/M Transition 185 6.57e-06 4.95e-05 0.20900 0.044300 -2.04e-01 3.00e-01 1.73e-06
SLC-mediated transmembrane transport 152 4.84e-05 2.93e-04 0.20900 -0.160000 -1.34e-01 6.86e-04 4.28e-03
Apoptotic factor-mediated response 20 2.73e-01 4.34e-01 0.20900 -0.198000 6.67e-02 1.26e-01 6.06e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 29 1.53e-01 2.89e-01 0.20800 0.088100 -1.89e-01 4.12e-01 7.82e-02
Cytokine Signaling in Immune system 593 4.40e-17 1.29e-15 0.20800 -0.122000 -1.69e-01 3.96e-07 2.71e-12
Signaling by NTRK3 (TRKC) 17 3.28e-01 4.83e-01 0.20800 -0.160000 -1.34e-01 2.54e-01 3.40e-01
Ephrin signaling 18 3.13e-01 4.70e-01 0.20800 -0.200000 5.64e-02 1.41e-01 6.79e-01
MET activates RAS signaling 11 4.93e-01 6.40e-01 0.20800 -0.166000 1.25e-01 3.41e-01 4.71e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 6.39e-02 1.53e-01 0.20800 -0.143000 1.51e-01 1.05e-01 8.77e-02
HIV Infection 223 6.34e-07 6.42e-06 0.20800 -0.039200 -2.04e-01 3.13e-01 1.63e-07
Regulation of TLR by endogenous ligand 15 3.81e-01 5.35e-01 0.20800 -0.205000 3.43e-02 1.70e-01 8.18e-01
GPER1 signaling 37 9.06e-02 1.99e-01 0.20700 -0.090500 -1.87e-01 3.41e-01 4.94e-02
Downstream signaling of activated FGFR2 21 2.62e-01 4.24e-01 0.20700 0.137000 -1.56e-01 2.79e-01 2.17e-01
Signaling by Hippo 20 2.77e-01 4.37e-01 0.20700 0.207000 1.33e-04 1.09e-01 9.99e-01
Recycling pathway of L1 41 7.13e-02 1.65e-01 0.20700 -0.065100 -1.96e-01 4.71e-01 2.96e-02
Signaling by FGFR 70 1.17e-02 3.98e-02 0.20700 0.066300 -1.96e-01 3.38e-01 4.63e-03
PI Metabolism 78 7.39e-03 2.67e-02 0.20600 -0.100000 1.80e-01 1.26e-01 6.02e-03
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 3.62e-01 5.16e-01 0.20600 -0.011900 2.06e-01 9.34e-01 1.54e-01
Metabolism of proteins 1626 3.90e-41 3.37e-39 0.20500 0.029000 -2.03e-01 5.43e-02 1.18e-41
RNA Polymerase III Transcription Termination 23 2.37e-01 3.95e-01 0.20500 0.180000 -9.89e-02 1.36e-01 4.12e-01
Transport of the SLBP Dependant Mature mRNA 36 1.06e-01 2.22e-01 0.20500 -0.136000 1.54e-01 1.59e-01 1.10e-01
DNA Damage/Telomere Stress Induced Senescence 33 1.28e-01 2.52e-01 0.20500 0.110000 -1.73e-01 2.74e-01 8.61e-02
Basigin interactions 21 2.64e-01 4.26e-01 0.20500 -0.159000 -1.29e-01 2.07e-01 3.06e-01
O-linked glycosylation of mucins 42 7.06e-02 1.64e-01 0.20500 -0.088300 -1.85e-01 3.22e-01 3.84e-02
Transcription of E2F targets under negative control by DREAM complex 18 3.20e-01 4.75e-01 0.20500 -0.118000 -1.67e-01 3.85e-01 2.20e-01
Formation of WDR5-containing histone-modifying complexes 42 7.32e-02 1.68e-01 0.20400 -0.057200 1.96e-01 5.21e-01 2.78e-02
Meiotic synapsis 31 1.45e-01 2.77e-01 0.20400 0.194000 -6.58e-02 6.22e-02 5.26e-01
G beta:gamma signalling through PLC beta 15 3.97e-01 5.52e-01 0.20400 -0.107000 1.73e-01 4.74e-01 2.45e-01
Interleukin-12 signaling 41 7.74e-02 1.77e-01 0.20400 -0.081400 -1.87e-01 3.67e-01 3.88e-02
DNA Damage Recognition in GG-NER 38 9.67e-02 2.07e-01 0.20300 0.052800 -1.96e-01 5.73e-01 3.65e-02
TP53 Regulates Transcription of DNA Repair Genes 61 2.38e-02 7.13e-02 0.20300 0.075200 -1.89e-01 3.10e-01 1.08e-02
activated TAK1 mediates p38 MAPK activation 23 2.41e-01 3.98e-01 0.20300 -0.002680 -2.03e-01 9.82e-01 9.19e-02
Amyloid fiber formation 41 7.82e-02 1.77e-01 0.20300 -0.091800 -1.81e-01 3.09e-01 4.48e-02
SUMOylation of ubiquitinylation proteins 39 9.20e-02 2.00e-01 0.20300 -0.173000 1.06e-01 6.11e-02 2.54e-01
Sensory perception of taste 16 3.77e-01 5.30e-01 0.20300 -0.177000 9.90e-02 2.21e-01 4.93e-01
Signaling by KIT in disease 20 2.91e-01 4.53e-01 0.20200 -0.154000 -1.31e-01 2.34e-01 3.10e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.91e-01 4.53e-01 0.20200 -0.154000 -1.31e-01 2.34e-01 3.10e-01
MET receptor recycling 10 5.43e-01 6.82e-01 0.20200 0.023900 2.00e-01 8.96e-01 2.73e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 5.43e-01 6.82e-01 0.20200 0.200000 2.11e-02 2.73e-01 9.08e-01
Mitotic Anaphase 218 2.29e-06 1.99e-05 0.20100 0.065200 -1.90e-01 9.77e-02 1.34e-06
TICAM1, RIP1-mediated IKK complex recruitment 19 3.19e-01 4.74e-01 0.20100 0.117000 -1.64e-01 3.77e-01 2.17e-01
Diseases of metabolism 206 3.97e-06 3.19e-05 0.20100 -0.117000 -1.64e-01 3.98e-03 5.24e-05
TICAM1,TRAF6-dependent induction of TAK1 complex 11 5.14e-01 6.56e-01 0.20100 -0.009490 -2.01e-01 9.57e-01 2.49e-01
Regulation of CDH11 function 10 5.48e-01 6.86e-01 0.20100 0.041500 -1.96e-01 8.20e-01 2.83e-01
RUNX2 regulates osteoblast differentiation 22 2.63e-01 4.25e-01 0.20100 -0.107000 -1.70e-01 3.86e-01 1.68e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.27e-01 2.50e-01 0.20000 -0.156000 -1.27e-01 1.17e-01 2.02e-01
Metabolism of RNA 693 7.30e-18 2.28e-16 0.20000 0.144000 -1.38e-01 1.23e-10 6.66e-10
Synthesis of bile acids and bile salts 26 2.09e-01 3.59e-01 0.20000 0.151000 1.30e-01 1.82e-01 2.50e-01
RMTs methylate histone arginines 33 1.39e-01 2.67e-01 0.19900 -0.060900 -1.90e-01 5.45e-01 5.95e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 2.70e-03 1.13e-02 0.19900 -0.191000 5.33e-02 9.00e-04 3.55e-01
ER Quality Control Compartment (ERQC) 21 2.88e-01 4.52e-01 0.19900 -0.035700 -1.95e-01 7.77e-01 1.21e-01
Removal of the Flap Intermediate from the C-strand 17 3.70e-01 5.24e-01 0.19800 0.111000 -1.64e-01 4.27e-01 2.41e-01
Mitotic Metaphase and Anaphase 219 3.05e-06 2.56e-05 0.19800 0.065600 -1.87e-01 9.47e-02 1.85e-06
Interaction between L1 and Ankyrins 25 2.30e-01 3.88e-01 0.19800 0.197000 -1.99e-02 8.80e-02 8.63e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 4.13e-01 5.67e-01 0.19800 -0.035200 -1.95e-01 8.14e-01 1.91e-01
Neurexins and neuroligins 41 8.87e-02 1.95e-01 0.19800 -0.133000 -1.47e-01 1.41e-01 1.05e-01
Hemostasis 487 7.53e-13 1.98e-11 0.19700 -0.118000 -1.58e-01 8.09e-06 2.70e-09
Transcriptional Regulation by NPAS4 30 1.75e-01 3.16e-01 0.19700 0.197000 9.44e-03 6.21e-02 9.29e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 66 2.14e-02 6.66e-02 0.19700 -0.191000 -4.75e-02 7.25e-03 5.05e-01
Activation of BH3-only proteins 28 1.96e-01 3.43e-01 0.19700 -0.012200 -1.97e-01 9.11e-01 7.18e-02
Purine salvage 12 4.98e-01 6.43e-01 0.19700 0.009310 -1.97e-01 9.55e-01 2.38e-01
Protein localization 155 1.36e-04 7.68e-04 0.19600 -0.008260 -1.96e-01 8.59e-01 2.51e-05
Telomere Maintenance 69 1.93e-02 6.14e-02 0.19600 0.106000 -1.66e-01 1.29e-01 1.74e-02
Mitotic Telophase/Cytokinesis 13 4.73e-01 6.20e-01 0.19600 0.066700 1.84e-01 6.77e-01 2.51e-01
PLC beta mediated events 45 7.68e-02 1.75e-01 0.19600 -0.194000 2.75e-02 2.47e-02 7.50e-01
Deposition of new CENPA-containing nucleosomes at the centromere 30 1.83e-01 3.27e-01 0.19500 0.182000 -6.94e-02 8.40e-02 5.11e-01
Nucleosome assembly 30 1.83e-01 3.27e-01 0.19500 0.182000 -6.94e-02 8.40e-02 5.11e-01
Vpr-mediated nuclear import of PICs 34 1.47e-01 2.79e-01 0.19500 -0.124000 1.50e-01 2.11e-01 1.29e-01
SUMOylation of DNA replication proteins 46 7.34e-02 1.68e-01 0.19500 -0.195000 1.99e-03 2.23e-02 9.81e-01
Advanced glycosylation endproduct receptor signaling 12 5.03e-01 6.48e-01 0.19500 -0.159000 -1.12e-01 3.40e-01 5.02e-01
G beta:gamma signalling through PI3Kgamma 20 3.26e-01 4.81e-01 0.19400 -0.169000 9.49e-02 1.90e-01 4.63e-01
RAF/MAP kinase cascade 233 2.48e-06 2.12e-05 0.19300 -0.003190 -1.93e-01 9.33e-01 3.79e-07
Telomere C-strand synthesis initiation 13 4.83e-01 6.29e-01 0.19300 0.193000 2.61e-04 2.27e-01 9.99e-01
Oxidative Stress Induced Senescence 69 2.15e-02 6.66e-02 0.19300 0.031400 -1.91e-01 6.52e-01 6.18e-03
Platelet activation, signaling and aggregation 222 4.39e-06 3.47e-05 0.19300 -0.140000 -1.33e-01 3.29e-04 6.79e-04
Regulation of NF-kappa B signaling 18 3.64e-01 5.17e-01 0.19300 -0.140000 -1.32e-01 3.04e-01 3.31e-01
Toll Like Receptor 3 (TLR3) Cascade 103 3.28e-03 1.34e-02 0.19300 -0.045200 -1.87e-01 4.28e-01 1.04e-03
Interferon Signaling 166 1.06e-04 6.05e-04 0.19300 -0.192000 -1.10e-02 1.96e-05 8.07e-01
RAB geranylgeranylation 55 4.85e-02 1.24e-01 0.19200 0.065800 -1.81e-01 3.99e-01 2.04e-02
Developmental Biology 777 2.08e-18 6.64e-17 0.19200 0.097000 -1.66e-01 4.80e-06 5.49e-15
Platelet Aggregation (Plug Formation) 30 1.91e-01 3.36e-01 0.19100 -0.123000 -1.46e-01 2.43e-01 1.66e-01
Deactivation of the beta-catenin transactivating complex 39 1.20e-01 2.41e-01 0.19100 0.088900 -1.69e-01 3.37e-01 6.75e-02
Defective pyroptosis 19 3.51e-01 5.06e-01 0.19100 0.128000 1.42e-01 3.34e-01 2.85e-01
NCAM1 interactions 31 1.82e-01 3.26e-01 0.19100 -0.103000 -1.60e-01 3.20e-01 1.22e-01
G1/S-Specific Transcription 25 2.56e-01 4.15e-01 0.19000 -0.185000 -4.70e-02 1.10e-01 6.84e-01
Ca-dependent events 33 1.70e-01 3.11e-01 0.18900 -0.189000 9.83e-03 6.00e-02 9.22e-01
MAPK1/MAPK3 signaling 239 3.28e-06 2.72e-05 0.18900 0.001520 -1.89e-01 9.68e-01 5.02e-07
EPHA-mediated growth cone collapse 22 3.12e-01 4.70e-01 0.18900 0.180000 -5.71e-02 1.45e-01 6.43e-01
Biotin transport and metabolism 11 5.55e-01 6.90e-01 0.18800 -0.180000 -5.71e-02 3.03e-01 7.43e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 13 5.04e-01 6.48e-01 0.18800 -0.145000 1.20e-01 3.66e-01 4.53e-01
Potential therapeutics for SARS 96 6.05e-03 2.23e-02 0.18800 -0.096800 -1.61e-01 1.01e-01 6.34e-03
Adaptive Immune System 654 2.76e-15 7.81e-14 0.18800 -0.144000 -1.20e-01 4.17e-10 1.69e-07
Signaling by WNT 241 3.88e-06 3.15e-05 0.18700 0.041200 -1.83e-01 2.72e-01 1.06e-06
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.83e-01 6.29e-01 0.18700 -0.166000 8.64e-02 2.82e-01 5.76e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 40 1.25e-01 2.48e-01 0.18700 0.053500 -1.79e-01 5.58e-01 5.03e-02
Caspase activation via Death Receptors in the presence of ligand 15 4.55e-01 6.04e-01 0.18700 -0.175000 -6.51e-02 2.41e-01 6.63e-01
Mitochondrial Fatty Acid Beta-Oxidation 34 1.72e-01 3.13e-01 0.18600 0.178000 -5.52e-02 7.26e-02 5.78e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 3.71e-01 5.25e-01 0.18600 0.183000 3.63e-02 1.68e-01 7.84e-01
Sulfur amino acid metabolism 23 2.99e-01 4.61e-01 0.18600 -0.149000 -1.12e-01 2.17e-01 3.52e-01
Infectious disease 835 1.34e-18 4.37e-17 0.18600 -0.000133 -1.86e-01 9.95e-01 1.17e-19
Regulation of localization of FOXO transcription factors 12 5.40e-01 6.81e-01 0.18600 0.149000 -1.12e-01 3.73e-01 5.03e-01
BBSome-mediated cargo-targeting to cilium 21 3.40e-01 4.97e-01 0.18600 0.175000 -6.29e-02 1.66e-01 6.18e-01
Sensory processing of sound by outer hair cells of the cochlea 35 1.64e-01 3.04e-01 0.18500 0.163000 8.75e-02 9.50e-02 3.71e-01
Transcriptional regulation of granulopoiesis 33 1.86e-01 3.30e-01 0.18400 0.002750 -1.84e-01 9.78e-01 6.67e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 2.20e-01 3.73e-01 0.18400 0.157000 -9.69e-02 1.37e-01 3.59e-01
Retinoid metabolism and transport 29 2.31e-01 3.89e-01 0.18400 0.081300 -1.65e-01 4.49e-01 1.23e-01
SHC1 events in ERBB4 signaling 12 5.41e-01 6.81e-01 0.18400 -0.165000 -8.20e-02 3.23e-01 6.23e-01
Interleukin-20 family signaling 14 4.88e-01 6.35e-01 0.18400 -0.114000 -1.45e-01 4.61e-01 3.48e-01
Leishmania infection 154 4.29e-04 2.24e-03 0.18300 -0.172000 -6.38e-02 2.32e-04 1.72e-01
Parasitic Infection Pathways 154 4.29e-04 2.24e-03 0.18300 -0.172000 -6.38e-02 2.32e-04 1.72e-01
Beta-catenin independent WNT signaling 133 1.33e-03 6.16e-03 0.18300 0.008470 -1.83e-01 8.66e-01 2.77e-04
Regulation of RUNX1 Expression and Activity 18 4.04e-01 5.58e-01 0.18300 -0.065600 -1.71e-01 6.30e-01 2.10e-01
Factors involved in megakaryocyte development and platelet production 119 2.58e-03 1.08e-02 0.18300 -0.071600 -1.68e-01 1.77e-01 1.55e-03
Signal regulatory protein family interactions 11 5.79e-01 7.08e-01 0.18300 -0.168000 7.15e-02 3.35e-01 6.81e-01
Post-translational modification: synthesis of GPI-anchored proteins 62 4.48e-02 1.16e-01 0.18300 -0.064700 -1.71e-01 3.78e-01 2.02e-02
PKA activation in glucagon signalling 15 4.70e-01 6.20e-01 0.18200 -0.111000 -1.45e-01 4.58e-01 3.31e-01
Cell recruitment (pro-inflammatory response) 24 3.02e-01 4.64e-01 0.18200 -0.180000 -2.78e-02 1.27e-01 8.14e-01
Purinergic signaling in leishmaniasis infection 24 3.02e-01 4.64e-01 0.18200 -0.180000 -2.78e-02 1.27e-01 8.14e-01
EGFR downregulation 27 2.61e-01 4.22e-01 0.18200 -0.140000 -1.15e-01 2.08e-01 2.99e-01
STING mediated induction of host immune responses 15 4.80e-01 6.28e-01 0.18100 -0.084100 1.61e-01 5.73e-01 2.81e-01
PIP3 activates AKT signaling 242 8.22e-06 5.95e-05 0.18100 0.010600 -1.81e-01 7.76e-01 1.34e-06
PRC2 methylates histones and DNA 19 3.96e-01 5.52e-01 0.18100 0.168000 -6.69e-02 2.05e-01 6.14e-01
Cargo recognition for clathrin-mediated endocytosis 90 1.22e-02 4.10e-02 0.18100 -0.177000 -3.79e-02 3.76e-03 5.35e-01
Notch-HLH transcription pathway 28 2.57e-01 4.17e-01 0.18100 -0.090900 1.56e-01 4.05e-01 1.53e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 3.07e-01 4.68e-01 0.18100 0.169000 6.34e-02 1.51e-01 5.91e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 3.07e-01 4.68e-01 0.18100 0.169000 6.34e-02 1.51e-01 5.91e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 24 3.07e-01 4.68e-01 0.18100 0.169000 6.34e-02 1.51e-01 5.91e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 24 3.07e-01 4.68e-01 0.18100 0.169000 6.34e-02 1.51e-01 5.91e-01
Ion homeostasis 43 1.23e-01 2.45e-01 0.18100 0.001550 -1.81e-01 9.86e-01 4.05e-02
Glutathione synthesis and recycling 10 6.13e-01 7.33e-01 0.18000 -0.166000 -7.04e-02 3.64e-01 7.00e-01
Disorders of transmembrane transporters 138 1.25e-03 5.88e-03 0.18000 -0.071100 -1.65e-01 1.50e-01 8.19e-04
Regulation of TP53 Activity through Methylation 19 3.96e-01 5.51e-01 0.18000 -0.117000 -1.36e-01 3.78e-01 3.03e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 2.19e-01 3.72e-01 0.17900 -0.126000 1.27e-01 2.17e-01 2.14e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 2.19e-01 3.72e-01 0.17900 -0.126000 1.27e-01 2.17e-01 2.14e-01
RUNX3 regulates NOTCH signaling 14 5.12e-01 6.55e-01 0.17800 0.012600 1.78e-01 9.35e-01 2.49e-01
Triglyceride metabolism 24 3.19e-01 4.74e-01 0.17800 -0.175000 -3.52e-02 1.39e-01 7.65e-01
RNA Polymerase I Promoter Escape 37 1.76e-01 3.18e-01 0.17800 0.173000 -3.92e-02 6.85e-02 6.80e-01
RUNX2 regulates bone development 28 2.64e-01 4.26e-01 0.17700 -0.082000 -1.57e-01 4.53e-01 1.50e-01
Bile acid and bile salt metabolism 29 2.52e-01 4.12e-01 0.17700 0.102000 1.45e-01 3.41e-01 1.77e-01
Signaling by NTRK1 (TRKA) 108 6.73e-03 2.46e-02 0.17600 0.009730 -1.76e-01 8.61e-01 1.58e-03
Diseases associated with O-glycosylation of proteins 55 7.94e-02 1.79e-01 0.17600 -0.136000 1.12e-01 8.02e-02 1.52e-01
Metabolism of cofactors 18 4.34e-01 5.86e-01 0.17600 0.011000 -1.76e-01 9.35e-01 1.97e-01
Miscellaneous transport and binding events 21 3.74e-01 5.28e-01 0.17600 -0.131000 -1.17e-01 2.98e-01 3.53e-01
Integration of energy metabolism 86 1.87e-02 5.96e-02 0.17600 -0.026500 -1.74e-01 6.71e-01 5.34e-03
Gap-filling DNA repair synthesis and ligation in GG-NER 25 3.18e-01 4.74e-01 0.17600 0.098500 -1.45e-01 3.94e-01 2.09e-01
Impaired BRCA2 binding to PALB2 23 3.44e-01 4.99e-01 0.17500 0.151000 8.89e-02 2.09e-01 4.60e-01
Rap1 signalling 13 5.52e-01 6.89e-01 0.17500 -0.100000 1.44e-01 5.30e-01 3.70e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 1.94e-01 3.40e-01 0.17500 0.072900 -1.59e-01 4.49e-01 9.84e-02
S Phase 157 8.39e-04 4.14e-03 0.17500 0.044600 -1.69e-01 3.36e-01 2.65e-04
Metabolism of steroid hormones 21 3.85e-01 5.41e-01 0.17400 -0.169000 -4.17e-02 1.81e-01 7.41e-01
MyD88-independent TLR4 cascade 107 7.96e-03 2.85e-02 0.17400 -0.052600 -1.65e-01 3.47e-01 3.12e-03
TRIF(TICAM1)-mediated TLR4 signaling 107 7.96e-03 2.85e-02 0.17400 -0.052600 -1.65e-01 3.47e-01 3.12e-03
Cyclin A/B1/B2 associated events during G2/M transition 22 3.70e-01 5.24e-01 0.17300 -0.034000 -1.70e-01 7.83e-01 1.67e-01
Plasma lipoprotein clearance 32 2.38e-01 3.95e-01 0.17300 -0.173000 -3.46e-03 9.02e-02 9.73e-01
Signaling by ALK fusions and activated point mutants 54 8.87e-02 1.95e-01 0.17300 -0.033800 -1.70e-01 6.68e-01 3.12e-02
Signaling by ALK in cancer 54 8.87e-02 1.95e-01 0.17300 -0.033800 -1.70e-01 6.68e-01 3.12e-02
Muscle contraction 153 1.11e-03 5.33e-03 0.17300 -0.003770 -1.73e-01 9.36e-01 2.27e-04
Estrogen-dependent gene expression 89 1.95e-02 6.18e-02 0.17300 0.157000 -7.23e-02 1.06e-02 2.39e-01
Acyl chain remodelling of PS 12 5.91e-01 7.16e-01 0.17200 -0.084600 1.49e-01 6.12e-01 3.70e-01
APC-Cdc20 mediated degradation of Nek2A 25 3.36e-01 4.94e-01 0.17100 0.080800 -1.51e-01 4.85e-01 1.91e-01
Transport of small molecules 526 1.59e-10 3.49e-09 0.17100 -0.115000 -1.26e-01 6.63e-06 7.86e-07
Synthesis of PC 23 3.63e-01 5.17e-01 0.17100 -0.117000 -1.24e-01 3.31e-01 3.03e-01
Export of Viral Ribonucleoproteins from Nucleus 33 2.41e-01 3.98e-01 0.17000 -0.094700 1.42e-01 3.46e-01 1.59e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 3.85e-01 5.41e-01 0.17000 0.013300 -1.70e-01 9.14e-01 1.68e-01
Heme biosynthesis 13 5.73e-01 7.04e-01 0.17000 0.115000 -1.25e-01 4.75e-01 4.34e-01
TP53 Regulates Transcription of Cell Death Genes 40 1.76e-01 3.18e-01 0.17000 -0.138000 -9.89e-02 1.32e-01 2.79e-01
Oncogene Induced Senescence 33 2.41e-01 3.98e-01 0.17000 -0.013700 -1.69e-01 8.92e-01 9.30e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 6.21e-01 7.38e-01 0.17000 0.062200 1.58e-01 7.21e-01 3.65e-01
Neddylation 223 8.05e-05 4.71e-04 0.16900 0.020900 -1.68e-01 5.90e-01 1.61e-05
Glutamate Neurotransmitter Release Cycle 22 3.91e-01 5.48e-01 0.16900 0.012300 -1.68e-01 9.21e-01 1.72e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 2.17e-01 3.71e-01 0.16800 0.022100 -1.67e-01 8.18e-01 8.30e-02
MAPK family signaling cascades 274 1.10e-05 7.55e-05 0.16800 0.024400 -1.66e-01 4.88e-01 2.19e-06
Eicosanoid ligand-binding receptors 14 5.51e-01 6.88e-01 0.16800 -0.129000 -1.07e-01 4.04e-01 4.86e-01
RHOV GTPase cycle 34 2.38e-01 3.95e-01 0.16800 0.034300 1.64e-01 7.29e-01 9.79e-02
IGF1R signaling cascade 39 1.96e-01 3.43e-01 0.16800 0.049600 -1.60e-01 5.92e-01 8.38e-02
SIRT1 negatively regulates rRNA expression 14 5.53e-01 6.89e-01 0.16700 0.156000 5.96e-02 3.11e-01 7.00e-01
Nuclear signaling by ERBB4 28 3.11e-01 4.70e-01 0.16700 -0.163000 3.77e-02 1.36e-01 7.30e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 3.11e-01 4.70e-01 0.16700 0.162000 -4.02e-02 1.37e-01 7.13e-01
HCMV Infection 99 1.67e-02 5.37e-02 0.16700 0.052400 -1.59e-01 3.68e-01 6.44e-03
Rev-mediated nuclear export of HIV RNA 35 2.36e-01 3.93e-01 0.16700 -0.139000 9.23e-02 1.55e-01 3.45e-01
Synthesis of PA 29 3.02e-01 4.64e-01 0.16600 -0.158000 5.29e-02 1.41e-01 6.22e-01
Synaptic adhesion-like molecules 18 4.76e-01 6.25e-01 0.16600 0.069400 -1.51e-01 6.10e-01 2.67e-01
Intracellular signaling by second messengers 278 1.17e-05 7.96e-05 0.16600 -0.009550 -1.66e-01 7.84e-01 1.97e-06
G0 and Early G1 25 3.54e-01 5.09e-01 0.16600 -0.140000 -8.84e-02 2.24e-01 4.44e-01
PKMTs methylate histone lysines 42 1.77e-01 3.19e-01 0.16600 0.018100 1.65e-01 8.39e-01 6.45e-02
RND1 GTPase cycle 37 2.16e-01 3.68e-01 0.16600 0.147000 7.60e-02 1.21e-01 4.24e-01
RHO GTPases Activate NADPH Oxidases 21 4.21e-01 5.73e-01 0.16600 -0.165000 -9.54e-03 1.89e-01 9.40e-01
Golgi Associated Vesicle Biogenesis 55 1.03e-01 2.19e-01 0.16600 -0.156000 -5.62e-02 4.57e-02 4.71e-01
Signaling by FLT3 ITD and TKD mutants 15 5.44e-01 6.82e-01 0.16500 0.143000 -8.31e-02 3.38e-01 5.77e-01
Fatty acyl-CoA biosynthesis 30 2.94e-01 4.57e-01 0.16500 -0.036400 -1.61e-01 7.30e-01 1.28e-01
Formation of Fibrin Clot (Clotting Cascade) 20 4.45e-01 5.94e-01 0.16400 0.017300 -1.64e-01 8.94e-01 2.06e-01
Effects of PIP2 hydrolysis 22 4.09e-01 5.62e-01 0.16400 -0.156000 -5.07e-02 2.04e-01 6.80e-01
Cellular Senescence 132 5.03e-03 1.91e-02 0.16400 0.018000 -1.63e-01 7.21e-01 1.21e-03
Vitamin B5 (pantothenate) metabolism 16 5.22e-01 6.64e-01 0.16400 -0.159000 -3.95e-02 2.69e-01 7.85e-01
RHO GTPases activate PAKs 20 4.49e-01 5.97e-01 0.16400 0.145000 -7.78e-02 2.63e-01 5.47e-01
Sema3A PAK dependent Axon repulsion 16 5.24e-01 6.66e-01 0.16400 -0.164000 -1.17e-02 2.57e-01 9.36e-01
RHOU GTPase cycle 39 2.11e-01 3.62e-01 0.16400 -0.128000 1.02e-01 1.66e-01 2.69e-01
Growth hormone receptor signaling 20 4.45e-01 5.94e-01 0.16400 -0.079500 -1.43e-01 5.38e-01 2.68e-01
Signaling by Leptin 10 6.72e-01 7.76e-01 0.16400 0.126000 -1.04e-01 4.89e-01 5.69e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 5.27e-01 6.67e-01 0.16400 -0.164000 1.70e-03 2.57e-01 9.91e-01
Retrograde transport at the Trans-Golgi-Network 49 1.40e-01 2.68e-01 0.16400 -0.161000 -2.80e-02 5.11e-02 7.34e-01
Apoptosis 161 1.72e-03 7.67e-03 0.16300 0.012000 -1.63e-01 7.93e-01 3.69e-04
Signaling by NODAL 13 5.93e-01 7.16e-01 0.16300 0.083400 1.40e-01 6.03e-01 3.81e-01
RAF activation 34 2.58e-01 4.18e-01 0.16300 -0.022100 -1.62e-01 8.24e-01 1.03e-01
CaM pathway 31 2.93e-01 4.56e-01 0.16300 -0.161000 2.53e-02 1.21e-01 8.08e-01
Calmodulin induced events 31 2.93e-01 4.56e-01 0.16300 -0.161000 2.53e-02 1.21e-01 8.08e-01
Formation of apoptosome 11 6.48e-01 7.60e-01 0.16300 -0.032000 1.59e-01 8.54e-01 3.60e-01
Regulation of the apoptosome activity 11 6.48e-01 7.60e-01 0.16300 -0.032000 1.59e-01 8.54e-01 3.60e-01
ADP signalling through P2Y purinoceptor 1 20 4.55e-01 6.04e-01 0.16200 -0.161000 -1.65e-02 2.13e-01 8.99e-01
Physiological factors 10 6.78e-01 7.79e-01 0.16200 0.136000 -8.69e-02 4.55e-01 6.34e-01
Diseases of programmed cell death 47 1.58e-01 2.94e-01 0.16200 -0.051000 -1.53e-01 5.45e-01 6.89e-02
Depolymerization of the Nuclear Lamina 15 5.54e-01 6.89e-01 0.16100 -0.134000 -9.03e-02 3.69e-01 5.45e-01
Base Excision Repair 50 1.44e-01 2.75e-01 0.16100 0.064100 -1.48e-01 4.33e-01 7.00e-02
Signaling by Erythropoietin 24 3.95e-01 5.51e-01 0.16100 -0.131000 9.39e-02 2.66e-01 4.26e-01
Ub-specific processing proteases 155 2.57e-03 1.08e-02 0.16100 0.035000 -1.57e-01 4.52e-01 7.32e-04
Pyroptosis 21 4.40e-01 5.91e-01 0.16100 -0.141000 -7.81e-02 2.64e-01 5.36e-01
Post-translational protein modification 1189 1.89e-19 6.95e-18 0.16100 -0.038800 -1.56e-01 2.54e-02 2.46e-19
IRS-related events triggered by IGF1R 38 2.35e-01 3.93e-01 0.16000 0.076200 -1.41e-01 4.16e-01 1.33e-01
Cytosolic sulfonation of small molecules 18 4.98e-01 6.43e-01 0.16000 -0.123000 -1.02e-01 3.65e-01 4.54e-01
Tryptophan catabolism 10 6.84e-01 7.81e-01 0.16000 -0.146000 6.59e-02 4.25e-01 7.18e-01
GRB2 events in ERBB2 signaling 14 5.87e-01 7.13e-01 0.16000 -0.156000 3.16e-02 3.11e-01 8.38e-01
Processing of SMDT1 15 5.68e-01 7.00e-01 0.15900 0.145000 -6.64e-02 3.32e-01 6.56e-01
NOD1/2 Signaling Pathway 36 2.54e-01 4.14e-01 0.15900 -0.152000 -4.76e-02 1.15e-01 6.21e-01
Killing mechanisms 10 6.82e-01 7.81e-01 0.15900 -0.122000 -1.02e-01 5.05e-01 5.75e-01
WNT5:FZD7-mediated leishmania damping 10 6.82e-01 7.81e-01 0.15900 -0.122000 -1.02e-01 5.05e-01 5.75e-01
NRAGE signals death through JNK 56 1.24e-01 2.46e-01 0.15800 -0.150000 4.94e-02 5.15e-02 5.23e-01
G beta:gamma signalling through CDC42 15 5.74e-01 7.04e-01 0.15800 -0.088700 1.30e-01 5.52e-01 3.82e-01
Signaling by WNT in cancer 28 3.55e-01 5.09e-01 0.15800 0.055000 -1.48e-01 6.15e-01 1.76e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.13e-01 5.67e-01 0.15700 0.064100 -1.44e-01 5.87e-01 2.23e-01
L1CAM interactions 102 2.35e-02 7.09e-02 0.15700 0.029100 -1.55e-01 6.12e-01 7.02e-03
mRNA 3’-end processing 57 1.25e-01 2.47e-01 0.15700 -0.081900 1.34e-01 2.85e-01 8.06e-02
Glycerophospholipid biosynthesis 100 2.56e-02 7.57e-02 0.15700 -0.156000 -1.29e-02 7.01e-03 8.24e-01
PI3K Cascade 31 3.23e-01 4.78e-01 0.15600 0.011000 -1.56e-01 9.16e-01 1.34e-01
Laminin interactions 27 3.74e-01 5.28e-01 0.15600 0.155000 -1.93e-02 1.64e-01 8.62e-01
FRS-mediated FGFR1 signaling 15 5.81e-01 7.08e-01 0.15600 0.142000 -6.49e-02 3.42e-01 6.63e-01
Signaling by FGFR1 40 2.36e-01 3.93e-01 0.15600 0.052600 -1.47e-01 5.65e-01 1.08e-01
RIPK1-mediated regulated necrosis 30 3.38e-01 4.95e-01 0.15600 0.046900 -1.48e-01 6.56e-01 1.59e-01
Regulation of necroptotic cell death 30 3.38e-01 4.95e-01 0.15600 0.046900 -1.48e-01 6.56e-01 1.59e-01
Sialic acid metabolism 27 3.73e-01 5.27e-01 0.15600 -0.056400 -1.45e-01 6.12e-01 1.92e-01
Thrombin signalling through proteinase activated receptors (PARs) 24 4.19e-01 5.72e-01 0.15600 -0.155000 7.67e-03 1.88e-01 9.48e-01
Chromosome Maintenance 92 3.73e-02 1.01e-01 0.15500 0.109000 -1.10e-01 6.97e-02 6.74e-02
RET signaling 32 3.12e-01 4.70e-01 0.15500 -0.133000 -8.09e-02 1.94e-01 4.28e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.75e-01 4.35e-01 0.15400 -0.039100 -1.49e-01 6.85e-01 1.21e-01
Signaling by NOTCH 176 1.98e-03 8.66e-03 0.15400 -0.014100 -1.54e-01 7.47e-01 4.47e-04
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 6.54e-01 7.65e-01 0.15400 -0.129000 8.50e-02 4.40e-01 6.10e-01
Activation of NMDA receptors and postsynaptic events 77 6.68e-02 1.58e-01 0.15400 0.104000 -1.13e-01 1.13e-01 8.59e-02
Cytoprotection by HMOX1 58 1.26e-01 2.49e-01 0.15400 -0.071300 -1.37e-01 3.48e-01 7.20e-02
Phospholipid metabolism 177 2.30e-03 9.92e-03 0.15300 -0.133000 7.51e-02 2.32e-03 8.51e-02
Signaling by Receptor Tyrosine Kinases 468 1.11e-07 1.27e-06 0.15300 -0.080100 -1.30e-01 3.08e-03 1.62e-06
HDMs demethylate histones 21 4.79e-01 6.28e-01 0.15200 -0.140000 -6.02e-02 2.67e-01 6.33e-01
ERBB2 Activates PTK6 Signaling 11 6.84e-01 7.81e-01 0.15200 -0.122000 9.10e-02 4.83e-01 6.01e-01
Post NMDA receptor activation events 65 1.09e-01 2.27e-01 0.15200 0.083800 -1.26e-01 2.43e-01 7.80e-02
Signaling by FGFR in disease 53 1.66e-01 3.06e-01 0.15100 0.059900 -1.39e-01 4.51e-01 8.08e-02
Class A/1 (Rhodopsin-like receptors) 144 7.36e-03 2.67e-02 0.15100 -0.069000 -1.34e-01 1.53e-01 5.48e-03
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.51e-01 5.06e-01 0.15100 0.130000 -7.72e-02 2.12e-01 4.57e-01
G-protein mediated events 49 1.90e-01 3.34e-01 0.15100 -0.150000 1.13e-02 6.88e-02 8.91e-01
Death Receptor Signaling 147 6.90e-03 2.52e-02 0.15000 -0.128000 -7.95e-02 7.68e-03 9.64e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 82 6.28e-02 1.51e-01 0.15000 -0.081400 -1.26e-01 2.03e-01 4.92e-02
Vesicle-mediated transport 607 2.34e-09 4.30e-08 0.15000 -0.110000 -1.01e-01 3.78e-06 2.22e-05
Diseases of mitotic cell cycle 38 2.82e-01 4.44e-01 0.15000 0.035900 -1.45e-01 7.02e-01 1.21e-01
Late Phase of HIV Life Cycle 132 1.26e-02 4.22e-02 0.15000 0.041900 -1.44e-01 4.06e-01 4.44e-03
SUMOylation of SUMOylation proteins 35 3.14e-01 4.71e-01 0.14900 -0.105000 1.06e-01 2.80e-01 2.79e-01
Formation of TC-NER Pre-Incision Complex 53 1.74e-01 3.16e-01 0.14900 0.084600 -1.23e-01 2.87e-01 1.22e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 6.25e-01 7.41e-01 0.14900 -0.128000 -7.70e-02 4.08e-01 6.18e-01
Protein-protein interactions at synapses 63 1.23e-01 2.45e-01 0.14900 -0.032300 -1.45e-01 6.57e-01 4.60e-02
Metabolism 1726 5.00e-23 2.37e-21 0.14800 -0.011100 -1.48e-01 4.50e-01 5.60e-24
G alpha (12/13) signalling events 70 1.02e-01 2.15e-01 0.14800 -0.126000 7.83e-02 6.81e-02 2.58e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 6.75e-01 7.77e-01 0.14800 0.116000 -9.30e-02 4.88e-01 5.77e-01
Signaling by cytosolic FGFR1 fusion mutants 18 5.55e-01 6.90e-01 0.14800 -0.071100 1.30e-01 6.02e-01 3.39e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 6.08e-01 7.29e-01 0.14800 0.115000 9.31e-02 4.40e-01 5.33e-01
DAG and IP3 signaling 37 2.97e-01 4.60e-01 0.14800 -0.143000 -3.69e-02 1.32e-01 6.98e-01
Signaling by SCF-KIT 41 2.63e-01 4.25e-01 0.14800 -0.147000 1.14e-02 1.03e-01 9.00e-01
Methylation 12 6.79e-01 7.80e-01 0.14700 0.076800 -1.26e-01 6.45e-01 4.51e-01
Intrinsic Pathway for Apoptosis 52 1.84e-01 3.28e-01 0.14700 -0.100000 -1.08e-01 2.12e-01 1.80e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 1.17e-01 2.40e-01 0.14700 -0.108000 -9.96e-02 1.30e-01 1.62e-01
Meiosis 50 2.03e-01 3.51e-01 0.14700 0.126000 -7.53e-02 1.24e-01 3.57e-01
Programmed Cell Death 188 2.53e-03 1.07e-02 0.14700 0.011400 -1.46e-01 7.89e-01 5.61e-04
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 6.59e-01 7.69e-01 0.14600 -0.145000 2.16e-02 3.66e-01 8.93e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 4.32e-01 5.85e-01 0.14600 0.111000 9.49e-02 3.27e-01 4.03e-01
Prolactin receptor signaling 11 7.07e-01 7.98e-01 0.14600 -0.083900 1.19e-01 6.30e-01 4.94e-01
Regulation of FOXO transcriptional activity by acetylation 10 7.26e-01 8.16e-01 0.14600 0.129000 6.81e-02 4.81e-01 7.09e-01
CRMPs in Sema3A signaling 15 6.19e-01 7.36e-01 0.14600 -0.122000 -7.86e-02 4.12e-01 5.98e-01
Intrinsic Pathway of Fibrin Clot Formation 12 6.86e-01 7.81e-01 0.14500 0.111000 -9.39e-02 5.06e-01 5.73e-01
Negative regulation of FLT3 13 6.62e-01 7.71e-01 0.14500 -0.053200 -1.35e-01 7.40e-01 3.99e-01
Downstream signal transduction 28 4.13e-01 5.67e-01 0.14500 -0.076300 -1.23e-01 4.85e-01 2.61e-01
Sensory Perception 148 1.00e-02 3.46e-02 0.14400 0.141000 2.92e-02 3.02e-03 5.40e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.81e-01 3.24e-01 0.14400 0.009120 -1.44e-01 9.07e-01 6.47e-02
Interactions of Vpr with host cellular proteins 37 3.19e-01 4.74e-01 0.14400 -0.113000 8.97e-02 2.35e-01 3.45e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 6.91e-01 7.85e-01 0.14400 -0.136000 4.70e-02 4.15e-01 7.78e-01
Disease 1472 6.97e-19 2.38e-17 0.14400 -0.021800 -1.42e-01 1.67e-01 1.78e-19
Regulation of PTEN gene transcription 59 1.64e-01 3.04e-01 0.14400 0.066300 -1.28e-01 3.78e-01 9.03e-02
Inwardly rectifying K+ channels 22 5.12e-01 6.55e-01 0.14300 0.065900 -1.27e-01 5.92e-01 3.02e-01
Recognition of DNA damage by PCNA-containing replication complex 30 3.98e-01 5.53e-01 0.14300 0.142000 1.40e-02 1.77e-01 8.94e-01
Cell Cycle Checkpoints 239 7.43e-04 3.70e-03 0.14300 0.029700 -1.40e-01 4.30e-01 1.99e-04
Signalling to ERKs 33 3.62e-01 5.16e-01 0.14300 -0.099200 -1.03e-01 3.24e-01 3.07e-01
Dissolution of Fibrin Clot 10 7.35e-01 8.20e-01 0.14300 -0.046000 -1.35e-01 8.01e-01 4.59e-01
Constitutive Signaling by EGFRvIII 15 6.34e-01 7.50e-01 0.14300 -0.058000 1.30e-01 6.98e-01 3.82e-01
Signaling by EGFRvIII in Cancer 15 6.34e-01 7.50e-01 0.14300 -0.058000 1.30e-01 6.98e-01 3.82e-01
Downregulation of ERBB2 signaling 27 4.42e-01 5.93e-01 0.14300 0.074200 -1.22e-01 5.04e-01 2.73e-01
Drug ADME 58 1.72e-01 3.13e-01 0.14200 -0.142000 -1.18e-02 6.17e-02 8.76e-01
MET promotes cell motility 40 3.01e-01 4.63e-01 0.14200 0.000739 -1.42e-01 9.94e-01 1.21e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.18e-01 2.40e-01 0.14200 -0.080700 1.16e-01 2.37e-01 8.76e-02
PI3K/AKT Signaling in Cancer 83 8.27e-02 1.86e-01 0.14100 -0.046500 -1.34e-01 4.64e-01 3.55e-02
NoRC negatively regulates rRNA expression 52 2.12e-01 3.63e-01 0.14100 0.141000 1.09e-03 7.80e-02 9.89e-01
CD209 (DC-SIGN) signaling 20 5.48e-01 6.86e-01 0.14100 -0.109000 -9.02e-02 4.01e-01 4.85e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 7.02e-01 7.93e-01 0.14100 -0.051200 1.31e-01 7.59e-01 4.32e-01
EPHB-mediated forward signaling 39 3.19e-01 4.74e-01 0.14100 -0.112000 8.55e-02 2.28e-01 3.56e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 4.53e-01 6.02e-01 0.14000 0.030500 -1.37e-01 7.84e-01 2.19e-01
RNA Polymerase I Transcription Termination 30 4.15e-01 5.68e-01 0.14000 0.139000 1.42e-02 1.88e-01 8.93e-01
Listeria monocytogenes entry into host cells 18 5.88e-01 7.13e-01 0.14000 -0.109000 -8.78e-02 4.24e-01 5.19e-01
HIV Life Cycle 145 1.50e-02 4.88e-02 0.14000 0.014400 -1.39e-01 7.65e-01 3.90e-03
Regulation of TP53 Activity 149 1.30e-02 4.28e-02 0.14000 -0.035600 -1.35e-01 4.54e-01 4.47e-03
Signaling by NTRKs 124 2.76e-02 8.12e-02 0.13900 -0.027700 -1.36e-01 5.95e-01 8.77e-03
Transport of Mature Transcript to Cytoplasm 81 9.82e-02 2.09e-01 0.13900 -0.088000 1.08e-01 1.71e-01 9.38e-02
Stimuli-sensing channels 72 1.29e-01 2.53e-01 0.13900 -0.125000 6.02e-02 6.71e-02 3.77e-01
MyD88 cascade initiated on plasma membrane 94 6.76e-02 1.58e-01 0.13900 -0.011900 -1.38e-01 8.42e-01 2.08e-02
Toll Like Receptor 10 (TLR10) Cascade 94 6.76e-02 1.58e-01 0.13900 -0.011900 -1.38e-01 8.42e-01 2.08e-02
Toll Like Receptor 5 (TLR5) Cascade 94 6.76e-02 1.58e-01 0.13900 -0.011900 -1.38e-01 8.42e-01 2.08e-02
Downstream signaling of activated FGFR1 21 5.49e-01 6.86e-01 0.13800 0.130000 -4.79e-02 3.03e-01 7.04e-01
Signaling by EGFR 46 2.67e-01 4.28e-01 0.13800 -0.125000 -5.83e-02 1.42e-01 4.94e-01
Interleukin-6 signaling 11 7.32e-01 8.18e-01 0.13800 0.062400 -1.23e-01 7.20e-01 4.80e-01
Adherens junctions interactions 44 2.89e-01 4.53e-01 0.13800 0.075700 -1.15e-01 3.85e-01 1.86e-01
RHO GTPases Activate Formins 126 3.03e-02 8.69e-02 0.13700 0.057000 -1.25e-01 2.70e-01 1.58e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.54e-01 7.65e-01 0.13700 -0.113000 -7.77e-02 4.49e-01 6.02e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 5.27e-01 6.67e-01 0.13700 0.127000 -5.15e-02 2.93e-01 6.69e-01
SARS-CoV-1 activates/modulates innate immune responses 39 3.32e-01 4.88e-01 0.13700 -0.116000 -7.20e-02 2.09e-01 4.37e-01
SARS-CoV Infections 379 2.82e-05 1.80e-04 0.13700 -0.051100 -1.27e-01 8.87e-02 2.31e-05
Carnitine metabolism 13 6.93e-01 7.86e-01 0.13700 0.077400 1.13e-01 6.29e-01 4.82e-01
ERBB2 Regulates Cell Motility 13 6.98e-01 7.90e-01 0.13600 -0.075300 1.14e-01 6.38e-01 4.77e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 7.57e-01 8.35e-01 0.13600 -0.136000 3.65e-03 4.56e-01 9.84e-01
Ion transport by P-type ATPases 42 3.14e-01 4.71e-01 0.13600 0.128000 -4.75e-02 1.53e-01 5.94e-01
Toll Like Receptor 4 (TLR4) Cascade 137 2.27e-02 6.93e-02 0.13600 -0.057300 -1.23e-01 2.47e-01 1.29e-02
VxPx cargo-targeting to cilium 17 6.29e-01 7.46e-01 0.13600 -0.109000 8.08e-02 4.38e-01 5.64e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 4.63e-01 6.13e-01 0.13500 -0.003120 -1.35e-01 9.77e-01 2.15e-01
SHC1 events in ERBB2 signaling 20 5.76e-01 7.05e-01 0.13500 -0.125000 -5.14e-02 3.33e-01 6.90e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 7.03e-01 7.94e-01 0.13500 0.114000 -7.21e-02 4.76e-01 6.52e-01
Cytosolic sensors of pathogen-associated DNA 63 1.81e-01 3.24e-01 0.13500 -0.000401 -1.35e-01 9.96e-01 6.44e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 5.34e-02 1.32e-01 0.13500 -0.030500 -1.31e-01 5.85e-01 1.86e-02
Toll Like Receptor 2 (TLR2) Cascade 108 5.34e-02 1.32e-01 0.13500 -0.030500 -1.31e-01 5.85e-01 1.86e-02
Toll Like Receptor TLR1:TLR2 Cascade 108 5.34e-02 1.32e-01 0.13500 -0.030500 -1.31e-01 5.85e-01 1.86e-02
Toll Like Receptor TLR6:TLR2 Cascade 108 5.34e-02 1.32e-01 0.13500 -0.030500 -1.31e-01 5.85e-01 1.86e-02
Signaling by TGFB family members 112 5.25e-02 1.31e-01 0.13300 0.082800 -1.05e-01 1.30e-01 5.58e-02
Clathrin-mediated endocytosis 129 3.29e-02 9.21e-02 0.13300 -0.129000 -3.43e-02 1.18e-02 5.01e-01
Branched-chain amino acid catabolism 21 5.79e-01 7.08e-01 0.13200 -0.099700 8.72e-02 4.29e-01 4.89e-01
Formation of Incision Complex in GG-NER 43 3.29e-01 4.85e-01 0.13200 0.096400 -9.01e-02 2.74e-01 3.07e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 6.43e-01 7.58e-01 0.13200 -0.131000 7.68e-03 3.48e-01 9.56e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 5.71e-01 7.02e-01 0.13100 0.070700 -1.10e-01 5.66e-01 3.71e-01
Membrane Trafficking 572 5.94e-07 6.06e-06 0.13100 -0.090900 -9.42e-02 2.14e-04 1.26e-04
O-linked glycosylation 86 1.10e-01 2.29e-01 0.13100 -0.101000 -8.29e-02 1.06e-01 1.84e-01
Nuclear import of Rev protein 34 4.23e-01 5.75e-01 0.13100 -0.105000 7.78e-02 2.91e-01 4.32e-01
mTORC1-mediated signalling 24 5.45e-01 6.83e-01 0.13000 0.079900 -1.03e-01 4.98e-01 3.82e-01
Transcriptional Regulation by TP53 340 2.06e-04 1.14e-03 0.13000 0.006690 -1.30e-01 8.33e-01 3.85e-05
MAP kinase activation 63 2.06e-01 3.56e-01 0.13000 0.018800 -1.28e-01 7.96e-01 7.85e-02
Neurotransmitter release cycle 37 3.98e-01 5.53e-01 0.12900 0.052800 -1.18e-01 5.79e-01 2.14e-01
Presynaptic function of Kainate receptors 16 6.72e-01 7.76e-01 0.12900 -0.074700 1.05e-01 6.05e-01 4.65e-01
Cardiac conduction 91 1.05e-01 2.21e-01 0.12900 0.023700 -1.27e-01 6.96e-01 3.65e-02
Mitochondrial biogenesis 85 1.20e-01 2.41e-01 0.12900 -0.027600 -1.26e-01 6.61e-01 4.45e-02
Interactions of Rev with host cellular proteins 37 4.01e-01 5.55e-01 0.12900 -0.116000 5.65e-02 2.22e-01 5.52e-01
IRS-mediated signalling 35 4.21e-01 5.73e-01 0.12900 0.030700 -1.25e-01 7.53e-01 2.00e-01
Signal amplification 27 5.09e-01 6.53e-01 0.12900 -0.106000 -7.31e-02 3.41e-01 5.11e-01
SARS-CoV-2 Infection 265 1.53e-03 6.89e-03 0.12800 -0.053100 -1.17e-01 1.37e-01 1.09e-03
G alpha (z) signalling events 37 4.06e-01 5.59e-01 0.12800 0.064100 -1.11e-01 5.00e-01 2.43e-01
FOXO-mediated transcription of cell death genes 15 6.92e-01 7.86e-01 0.12800 0.002820 -1.28e-01 9.85e-01 3.90e-01
Transport of vitamins, nucleosides, and related molecules 29 4.92e-01 6.39e-01 0.12800 -0.030900 -1.24e-01 7.73e-01 2.49e-01
EML4 and NUDC in mitotic spindle formation 103 8.38e-02 1.88e-01 0.12700 0.037700 -1.22e-01 5.09e-01 3.30e-02
MyD88 dependent cascade initiated on endosome 101 8.69e-02 1.92e-01 0.12700 -0.047500 -1.18e-01 4.10e-01 4.10e-02
MicroRNA (miRNA) biogenesis 24 5.65e-01 6.97e-01 0.12700 0.059200 -1.12e-01 6.16e-01 3.43e-01
Signaling by TGF-beta Receptor Complex 90 1.18e-01 2.40e-01 0.12600 0.021300 -1.25e-01 7.27e-01 4.13e-02
Class I MHC mediated antigen processing & presentation 343 3.13e-04 1.68e-03 0.12600 -0.080600 -9.68e-02 1.05e-02 2.12e-03
Negative regulation of the PI3K/AKT network 89 1.20e-01 2.41e-01 0.12600 -0.062300 -1.09e-01 3.10e-01 7.45e-02
Heme signaling 44 3.54e-01 5.09e-01 0.12600 -0.036900 1.20e-01 6.72e-01 1.67e-01
RND3 GTPase cycle 36 4.24e-01 5.75e-01 0.12600 0.089900 8.79e-02 3.51e-01 3.62e-01
TRAF6 mediated NF-kB activation 23 5.82e-01 7.09e-01 0.12600 -0.121000 3.52e-02 3.17e-01 7.70e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 8.94e-02 1.96e-01 0.12600 -0.056300 -1.12e-01 3.26e-01 5.03e-02
Signaling by FLT3 fusion proteins 19 6.37e-01 7.53e-01 0.12500 0.088600 8.85e-02 5.04e-01 5.04e-01
Toll-like Receptor Cascades 157 2.67e-02 7.88e-02 0.12400 -0.104000 -6.81e-02 2.50e-02 1.41e-01
Sphingolipid de novo biosynthesis 36 4.35e-01 5.87e-01 0.12400 0.121000 2.75e-02 2.09e-01 7.75e-01
Cell Cycle, Mitotic 481 2.13e-05 1.40e-04 0.12400 0.008670 -1.24e-01 7.46e-01 3.66e-06
Interleukin-17 signaling 67 2.17e-01 3.70e-01 0.12400 -0.003830 -1.24e-01 9.57e-01 8.06e-02
Regulated Necrosis 51 3.11e-01 4.70e-01 0.12300 -0.030400 -1.20e-01 7.07e-01 1.39e-01
M Phase 344 4.72e-04 2.42e-03 0.12300 0.031200 -1.19e-01 3.22e-01 1.48e-04
Gap-filling DNA repair synthesis and ligation in TC-NER 64 2.38e-01 3.95e-01 0.12300 0.078300 -9.51e-02 2.79e-01 1.89e-01
Thromboxane signalling through TP receptor 19 6.48e-01 7.60e-01 0.12300 -0.121000 -2.36e-02 3.62e-01 8.59e-01
Nuclear Envelope Breakdown 53 3.03e-01 4.65e-01 0.12300 -0.113000 4.82e-02 1.54e-01 5.44e-01
Signaling by high-kinase activity BRAF mutants 31 4.97e-01 6.42e-01 0.12300 -0.119000 2.99e-02 2.50e-01 7.73e-01
FLT3 signaling in disease 27 5.44e-01 6.82e-01 0.12300 0.120000 -2.65e-02 2.80e-01 8.12e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 6.95e-01 7.88e-01 0.12300 -0.101000 -6.97e-02 4.84e-01 6.29e-01
B-WICH complex positively regulates rRNA expression 37 4.34e-01 5.86e-01 0.12300 0.119000 2.93e-02 2.10e-01 7.58e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 1.06e-01 2.22e-01 0.12200 -0.040400 -1.16e-01 4.86e-01 4.59e-02
Ion channel transport 133 5.08e-02 1.28e-01 0.12200 -0.104000 -6.37e-02 3.79e-02 2.05e-01
Defects in vitamin and cofactor metabolism 20 6.37e-01 7.53e-01 0.12200 0.106000 6.14e-02 4.13e-01 6.35e-01
Regulation of MECP2 expression and activity 29 5.26e-01 6.67e-01 0.12200 -0.108000 5.69e-02 3.14e-01 5.96e-01
Phase 0 - rapid depolarisation 23 6.00e-01 7.22e-01 0.12200 0.118000 -3.08e-02 3.27e-01 7.98e-01
IRF3-mediated induction of type I IFN 12 7.66e-01 8.41e-01 0.12200 -0.116000 3.71e-02 4.86e-01 8.24e-01
Negative epigenetic regulation of rRNA expression 55 2.94e-01 4.57e-01 0.12200 0.121000 1.07e-02 1.20e-01 8.91e-01
Signaling by MET 75 1.90e-01 3.34e-01 0.12200 -0.039800 -1.15e-01 5.52e-01 8.57e-02
Regulation of insulin secretion 59 2.71e-01 4.31e-01 0.12100 -0.032200 -1.17e-01 6.69e-01 1.20e-01
Glutamate and glutamine metabolism 11 7.83e-01 8.55e-01 0.12100 -0.031200 -1.17e-01 8.58e-01 5.01e-01
Sphingolipid metabolism 72 2.02e-01 3.50e-01 0.12100 -0.094500 -7.61e-02 1.66e-01 2.64e-01
GPCR downstream signalling 361 3.95e-04 2.07e-03 0.12100 -0.104000 -6.19e-02 7.02e-04 4.38e-02
Glucagon signaling in metabolic regulation 25 5.77e-01 7.06e-01 0.12100 -0.078700 -9.15e-02 4.96e-01 4.28e-01
p75 NTR receptor-mediated signalling 91 1.38e-01 2.65e-01 0.12100 -0.114000 -3.95e-02 6.06e-02 5.15e-01
ALK mutants bind TKIs 11 7.89e-01 8.60e-01 0.12000 0.055100 -1.07e-01 7.52e-01 5.39e-01
Insulin receptor signalling cascade 40 4.24e-01 5.75e-01 0.12000 0.031400 -1.16e-01 7.31e-01 2.05e-01
Resolution of Sister Chromatid Cohesion 112 9.42e-02 2.03e-01 0.11900 0.065000 -1.00e-01 2.35e-01 6.71e-02
Circadian Clock 66 2.53e-01 4.13e-01 0.11800 0.044200 -1.10e-01 5.35e-01 1.23e-01
Negative regulation of MET activity 20 6.57e-01 7.67e-01 0.11800 -0.114000 -2.97e-02 3.76e-01 8.18e-01
Resolution of D-Loop Structures 33 5.05e-01 6.48e-01 0.11800 -0.053800 1.05e-01 5.93e-01 2.96e-01
Transcriptional Regulation by E2F6 34 4.91e-01 6.39e-01 0.11800 0.108000 4.62e-02 2.74e-01 6.41e-01
CDC42 GTPase cycle 146 5.11e-02 1.29e-01 0.11800 -0.097000 6.64e-02 4.32e-02 1.67e-01
Signaling by VEGF 105 1.17e-01 2.40e-01 0.11700 -0.117000 -7.53e-03 3.87e-02 8.94e-01
Ovarian tumor domain proteases 35 4.86e-01 6.33e-01 0.11700 -0.053500 -1.04e-01 5.84e-01 2.87e-01
Antigen processing: Ubiquitination & Proteasome degradation 282 3.34e-03 1.36e-02 0.11700 -0.021700 -1.15e-01 5.32e-01 9.23e-04
Nucleotide catabolism 24 6.15e-01 7.33e-01 0.11600 -0.075900 -8.75e-02 5.20e-01 4.58e-01
Cell death signalling via NRAGE, NRIF and NADE 73 2.32e-01 3.89e-01 0.11600 -0.116000 6.16e-04 8.73e-02 9.93e-01
Ca2+ pathway 54 3.38e-01 4.95e-01 0.11500 0.105000 4.89e-02 1.84e-01 5.34e-01
Opioid Signalling 78 2.13e-01 3.65e-01 0.11500 -0.081600 -8.05e-02 2.13e-01 2.19e-01
Deubiquitination 226 1.28e-02 4.22e-02 0.11400 0.004910 -1.14e-01 8.99e-01 3.16e-03
Amine ligand-binding receptors 11 8.08e-01 8.74e-01 0.11400 0.114000 -1.43e-04 5.13e-01 9.99e-01
SUMOylation of intracellular receptors 27 5.91e-01 7.16e-01 0.11400 0.044800 1.04e-01 6.87e-01 3.48e-01
G beta:gamma signalling through BTK 13 7.80e-01 8.53e-01 0.11300 -0.064600 9.33e-02 6.87e-01 5.60e-01
HCMV Late Events 59 3.21e-01 4.75e-01 0.11300 -0.010800 -1.13e-01 8.86e-01 1.34e-01
Signaling by RAF1 mutants 36 5.01e-01 6.46e-01 0.11300 -0.113000 4.71e-05 2.40e-01 1.00e+00
TP53 Regulates Metabolic Genes 80 2.20e-01 3.74e-01 0.11300 0.066000 -9.17e-02 3.07e-01 1.56e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 5.99e-01 7.22e-01 0.11300 0.009510 -1.12e-01 9.32e-01 3.13e-01
Condensation of Prophase Chromosomes 19 6.96e-01 7.89e-01 0.11200 -0.041100 -1.05e-01 7.56e-01 4.30e-01
Constitutive Signaling by Aberrant PI3K in Cancer 56 3.45e-01 5.00e-01 0.11200 -0.069500 -8.82e-02 3.68e-01 2.54e-01
Nucleotide Excision Repair 110 1.30e-01 2.54e-01 0.11200 0.047400 -1.01e-01 3.91e-01 6.64e-02
GPCR ligand binding 197 2.54e-02 7.54e-02 0.11200 -0.038600 -1.05e-01 3.51e-01 1.12e-02
Glutathione conjugation 29 5.84e-01 7.11e-01 0.11200 0.068800 -8.81e-02 5.22e-01 4.12e-01
TBC/RABGAPs 44 4.39e-01 5.91e-01 0.11200 -0.109000 -2.49e-02 2.12e-01 7.75e-01
Signal transduction by L1 21 6.75e-01 7.77e-01 0.11100 -0.050400 -9.93e-02 6.89e-01 4.31e-01
RNA Polymerase I Promoter Clearance 56 3.58e-01 5.12e-01 0.11100 0.111000 -8.44e-03 1.53e-01 9.13e-01
RNA Polymerase I Transcription 56 3.58e-01 5.12e-01 0.11100 0.111000 -8.44e-03 1.53e-01 9.13e-01
Cell Cycle 591 2.99e-05 1.89e-04 0.11100 0.015700 -1.09e-01 5.17e-01 6.06e-06
SUMOylation of DNA methylation proteins 16 7.47e-01 8.27e-01 0.11000 0.015300 -1.09e-01 9.15e-01 4.49e-01
Reproduction 67 3.09e-01 4.70e-01 0.10900 0.102000 -3.72e-02 1.49e-01 5.99e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 5.11e-01 6.55e-01 0.10800 0.098100 4.57e-02 2.95e-01 6.26e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 6.47e-01 7.60e-01 0.10800 0.039700 -1.01e-01 7.31e-01 3.84e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 39 5.08e-01 6.51e-01 0.10800 0.097000 -4.79e-02 2.95e-01 6.05e-01
RHO GTPases activate KTN1 10 8.42e-01 8.94e-01 0.10800 -0.087300 6.29e-02 6.33e-01 7.30e-01
RHOQ GTPase cycle 57 3.77e-01 5.31e-01 0.10700 -0.051900 9.40e-02 4.98e-01 2.20e-01
Myogenesis 21 6.99e-01 7.91e-01 0.10700 0.094200 -5.09e-02 4.55e-01 6.86e-01
Regulation of signaling by CBL 22 6.86e-01 7.81e-01 0.10700 -0.107000 -2.81e-03 3.85e-01 9.82e-01
Extension of Telomeres 49 4.40e-01 5.92e-01 0.10600 0.044700 -9.63e-02 5.88e-01 2.44e-01
Signaling by GPCR 401 1.27e-03 5.91e-03 0.10600 -0.083300 -6.58e-02 4.33e-03 2.42e-02
Regulated proteolysis of p75NTR 11 8.30e-01 8.89e-01 0.10600 -0.098700 -3.89e-02 5.71e-01 8.23e-01
Toll Like Receptor 9 (TLR9) Cascade 105 1.70e-01 3.11e-01 0.10600 -0.050400 -9.33e-02 3.73e-01 9.88e-02
Activation of G protein gated Potassium channels 19 7.31e-01 8.17e-01 0.10500 0.065400 -8.28e-02 6.22e-01 5.32e-01
G protein gated Potassium channels 19 7.31e-01 8.17e-01 0.10500 0.065400 -8.28e-02 6.22e-01 5.32e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 7.31e-01 8.17e-01 0.10500 0.065400 -8.28e-02 6.22e-01 5.32e-01
mRNA Splicing 210 3.32e-02 9.25e-02 0.10500 0.097400 -3.91e-02 1.51e-02 3.29e-01
O-glycosylation of TSR domain-containing proteins 35 5.63e-01 6.96e-01 0.10500 -0.104000 1.11e-02 2.86e-01 9.09e-01
ESR-mediated signaling 152 8.61e-02 1.91e-01 0.10500 0.092300 -4.91e-02 4.97e-02 2.97e-01
Cilium Assembly 186 4.90e-02 1.25e-01 0.10400 0.102000 2.41e-02 1.71e-02 5.72e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 7.47e-01 8.27e-01 0.10400 -0.028100 1.00e-01 8.37e-01 4.61e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 7.60e-01 8.37e-01 0.10400 -0.103000 1.75e-02 4.64e-01 9.01e-01
Recruitment of NuMA to mitotic centrosomes 87 2.49e-01 4.10e-01 0.10400 0.074200 -7.28e-02 2.32e-01 2.41e-01
EPH-Ephrin signaling 82 2.67e-01 4.29e-01 0.10400 -0.101000 -2.12e-02 1.13e-01 7.40e-01
Early SARS-CoV-2 Infection Events 33 5.87e-01 7.13e-01 0.10300 -0.053600 -8.84e-02 5.94e-01 3.80e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 6.84e-01 7.81e-01 0.10300 0.022100 -1.01e-01 8.51e-01 3.94e-01
G-protein activation 18 7.55e-01 8.33e-01 0.10300 -0.095600 3.70e-02 4.83e-01 7.86e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 2.98e-01 4.60e-01 0.10200 0.052900 -8.76e-02 4.19e-01 1.81e-01
MAPK3 (ERK1) activation 10 8.55e-01 9.02e-01 0.10200 0.004770 1.02e-01 9.79e-01 5.77e-01
mRNA Splicing - Major Pathway 202 4.57e-02 1.18e-01 0.10200 0.088200 -5.11e-02 3.10e-02 2.11e-01
FOXO-mediated transcription 57 4.19e-01 5.72e-01 0.10100 0.096300 -3.12e-02 2.09e-01 6.84e-01
Transcriptional activation of mitochondrial biogenesis 49 4.71e-01 6.20e-01 0.10100 -0.100000 -1.35e-02 2.25e-01 8.70e-01
Resolution of Abasic Sites (AP sites) 38 5.59e-01 6.93e-01 0.10100 -0.052800 -8.58e-02 5.73e-01 3.60e-01
Polymerase switching on the C-strand of the telomere 26 6.73e-01 7.76e-01 0.10000 0.089500 4.56e-02 4.30e-01 6.88e-01
Diseases of signal transduction by growth factor receptors and second messengers 390 3.27e-03 1.34e-02 0.10000 -0.001300 -1.00e-01 9.65e-01 7.18e-04
SLC transporter disorders 70 3.54e-01 5.09e-01 0.09990 -0.094800 3.16e-02 1.70e-01 6.48e-01
SUMOylation of DNA damage response and repair proteins 77 3.16e-01 4.73e-01 0.09990 0.031000 9.50e-02 6.39e-01 1.50e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 8.24e-01 8.86e-01 0.09980 0.095600 -2.87e-02 5.51e-01 8.58e-01
Signaling by ERBB2 ECD mutants 16 7.89e-01 8.60e-01 0.09950 -0.000825 9.95e-02 9.95e-01 4.91e-01
Synthesis of very long-chain fatty acyl-CoAs 18 7.66e-01 8.41e-01 0.09950 -0.002640 -9.94e-02 9.85e-01 4.65e-01
HCMV Early Events 76 3.30e-01 4.85e-01 0.09920 0.045800 -8.80e-02 4.90e-01 1.85e-01
VEGFA-VEGFR2 Pathway 96 2.47e-01 4.07e-01 0.09880 -0.098700 -5.30e-03 9.51e-02 9.29e-01
Synthesis of PIPs at the plasma membrane 50 4.83e-01 6.29e-01 0.09870 0.007030 9.84e-02 9.31e-01 2.29e-01
Signaling by NTRK2 (TRKB) 22 7.31e-01 8.17e-01 0.09800 -0.083300 5.16e-02 4.99e-01 6.75e-01
Metabolism of vitamins and cofactors 156 1.08e-01 2.26e-01 0.09790 -0.009410 -9.75e-02 8.39e-01 3.58e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 32 6.34e-01 7.50e-01 0.09770 -0.028700 9.34e-02 7.79e-01 3.61e-01
Diseases of DNA repair 48 5.04e-01 6.48e-01 0.09740 0.092400 3.09e-02 2.68e-01 7.11e-01
Signaling by BRAF and RAF1 fusions 58 4.41e-01 5.93e-01 0.09730 -0.095600 1.81e-02 2.08e-01 8.12e-01
eNOS activation 11 8.55e-01 9.02e-01 0.09700 0.032900 9.13e-02 8.50e-01 6.00e-01
Activation of the pre-replicative complex 29 6.67e-01 7.73e-01 0.09700 0.080400 -5.43e-02 4.54e-01 6.13e-01
RHOD GTPase cycle 50 4.95e-01 6.41e-01 0.09660 0.080500 5.33e-02 3.25e-01 5.14e-01
Activation of gene expression by SREBF (SREBP) 42 5.59e-01 6.93e-01 0.09650 0.045500 -8.51e-02 6.10e-01 3.40e-01
TP53 Regulates Transcription of Cell Cycle Genes 44 5.39e-01 6.81e-01 0.09650 -0.048400 -8.34e-02 5.78e-01 3.38e-01
Signal Transduction 2031 1.74e-11 4.26e-10 0.09610 -0.013800 -9.51e-02 3.14e-01 3.47e-12
WNT ligand biogenesis and trafficking 16 8.03e-01 8.72e-01 0.09610 0.085400 -4.39e-02 5.54e-01 7.61e-01
PI3K events in ERBB2 signaling 14 8.26e-01 8.87e-01 0.09600 -0.061900 7.33e-02 6.88e-01 6.35e-01
RHO GTPase Effectors 244 3.73e-02 1.01e-01 0.09570 0.024200 -9.26e-02 5.16e-01 1.29e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 8.71e-01 9.11e-01 0.09560 0.021000 9.33e-02 9.08e-01 6.10e-01
Homologous DNA Pairing and Strand Exchange 41 5.71e-01 7.02e-01 0.09510 0.060700 7.32e-02 5.02e-01 4.17e-01
PKA activation 16 8.07e-01 8.74e-01 0.09410 -0.046000 -8.22e-02 7.50e-01 5.69e-01
Antiviral mechanism by IFN-stimulated genes 79 3.57e-01 5.11e-01 0.09390 -0.063900 6.88e-02 3.26e-01 2.91e-01
Voltage gated Potassium channels 15 8.21e-01 8.85e-01 0.09390 -0.037400 8.61e-02 8.02e-01 5.64e-01
G alpha (q) signalling events 129 1.85e-01 3.29e-01 0.09390 -0.092600 1.54e-02 6.96e-02 7.62e-01
Regulation of TP53 Activity through Phosphorylation 86 3.23e-01 4.78e-01 0.09390 0.002290 -9.38e-02 9.71e-01 1.33e-01
Termination of O-glycan biosynthesis 14 8.32e-01 8.90e-01 0.09360 0.000839 -9.36e-02 9.96e-01 5.44e-01
Cellular response to heat stress 96 2.89e-01 4.52e-01 0.09360 0.060800 -7.11e-02 3.04e-01 2.29e-01
Class B/2 (Secretin family receptors) 49 5.31e-01 6.72e-01 0.09330 0.059600 -7.18e-02 4.70e-01 3.85e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 3.40e-01 4.97e-01 0.09320 0.051700 -7.75e-02 4.13e-01 2.20e-01
Aflatoxin activation and detoxification 11 8.68e-01 9.08e-01 0.09280 0.012200 -9.20e-02 9.44e-01 5.97e-01
Cell-cell junction organization 63 4.49e-01 5.97e-01 0.09270 0.053700 -7.55e-02 4.61e-01 3.00e-01
Processing of DNA double-strand break ends 60 4.67e-01 6.16e-01 0.09250 0.039400 -8.37e-02 5.97e-01 2.63e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 6.04e-01 7.26e-01 0.09250 0.069300 6.12e-02 4.54e-01 5.09e-01
Diseases of DNA Double-Strand Break Repair 39 6.04e-01 7.26e-01 0.09250 0.069300 6.12e-02 4.54e-01 5.09e-01
Transmission across Chemical Synapses 187 9.82e-02 2.09e-01 0.09180 0.045300 -7.99e-02 2.86e-01 5.99e-02
Adenylate cyclase inhibitory pathway 12 8.59e-01 9.04e-01 0.09180 0.091700 2.47e-03 5.82e-01 9.88e-01
Activation of HOX genes during differentiation 65 4.45e-01 5.94e-01 0.09170 0.073800 -5.45e-02 3.04e-01 4.48e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 65 4.45e-01 5.94e-01 0.09170 0.073800 -5.45e-02 3.04e-01 4.48e-01
RNA Polymerase III Transcription Initiation 36 6.40e-01 7.54e-01 0.09140 0.043700 -8.03e-02 6.50e-01 4.05e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 5.39e-01 6.81e-01 0.09130 0.055900 -7.21e-02 4.94e-01 3.78e-01
Oncogenic MAPK signaling 74 4.00e-01 5.55e-01 0.09120 -0.088100 2.37e-02 1.90e-01 7.25e-01
Regulation of innate immune responses to cytosolic DNA 14 8.40e-01 8.94e-01 0.09120 0.008950 -9.08e-02 9.54e-01 5.56e-01
Transcriptional Regulation by VENTX 39 6.16e-01 7.34e-01 0.09110 -0.002450 -9.10e-02 9.79e-01 3.25e-01
Neurotransmitter receptors and postsynaptic signal transmission 141 1.80e-01 3.24e-01 0.09080 0.038400 -8.23e-02 4.32e-01 9.21e-02
Activation of GABAB receptors 31 6.85e-01 7.81e-01 0.09060 0.075700 -4.98e-02 4.66e-01 6.31e-01
GABA B receptor activation 31 6.85e-01 7.81e-01 0.09060 0.075700 -4.98e-02 4.66e-01 6.31e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 7.47e-01 8.27e-01 0.09020 0.089800 -8.33e-03 4.46e-01 9.44e-01
tRNA modification in the nucleus and cytosol 43 5.95e-01 7.18e-01 0.08990 0.089500 -8.17e-03 3.10e-01 9.26e-01
Anchoring of the basal body to the plasma membrane 95 3.18e-01 4.74e-01 0.08970 0.083600 3.26e-02 1.59e-01 5.83e-01
Phase II - Conjugation of compounds 68 4.45e-01 5.94e-01 0.08970 0.053200 -7.22e-02 4.48e-01 3.04e-01
RAC1 GTPase cycle 173 1.30e-01 2.54e-01 0.08950 -0.049300 7.46e-02 2.64e-01 9.07e-02
Dual incision in TC-NER 65 4.62e-01 6.13e-01 0.08940 0.079800 -4.04e-02 2.66e-01 5.73e-01
Telomere C-strand (Lagging Strand) Synthesis 34 6.67e-01 7.73e-01 0.08930 0.086000 -2.42e-02 3.86e-01 8.07e-01
RND2 GTPase cycle 36 6.53e-01 7.65e-01 0.08890 0.007730 8.85e-02 9.36e-01 3.58e-01
PKA-mediated phosphorylation of CREB 18 8.09e-01 8.74e-01 0.08880 -0.088300 9.19e-03 5.17e-01 9.46e-01
Peroxisomal protein import 57 5.18e-01 6.61e-01 0.08820 -0.043500 7.67e-02 5.70e-01 3.17e-01
RNA polymerase II transcribes snRNA genes 71 4.43e-01 5.94e-01 0.08800 0.077600 -4.15e-02 2.59e-01 5.46e-01
Lagging Strand Synthesis 20 7.97e-01 8.67e-01 0.08700 -0.000587 8.70e-02 9.96e-01 5.01e-01
Defective B3GALTL causes PpS 34 6.83e-01 7.81e-01 0.08670 -0.082900 2.56e-02 4.03e-01 7.96e-01
Activation of RAC1 11 8.84e-01 9.19e-01 0.08670 -0.046300 7.33e-02 7.90e-01 6.74e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 7.28e-01 8.17e-01 0.08670 0.042100 7.57e-02 7.00e-01 4.88e-01
SUMOylation of transcription factors 17 8.27e-01 8.87e-01 0.08660 -0.083500 2.31e-02 5.51e-01 8.69e-01
NCAM signaling for neurite out-growth 52 5.58e-01 6.93e-01 0.08620 -0.051400 -6.92e-02 5.22e-01 3.88e-01
SARS-CoV-2-host interactions 176 1.48e-01 2.80e-01 0.08590 0.036100 -7.79e-02 4.09e-01 7.49e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 63 5.00e-01 6.45e-01 0.08580 0.085800 -2.33e-03 2.39e-01 9.74e-01
Cargo trafficking to the periciliary membrane 45 6.12e-01 7.33e-01 0.08520 0.080800 2.69e-02 3.49e-01 7.55e-01
Sensory processing of sound by inner hair cells of the cochlea 49 5.92e-01 7.16e-01 0.08500 0.070500 -4.74e-02 3.93e-01 5.66e-01
Activation of SMO 16 8.43e-01 8.94e-01 0.08470 0.029300 -7.95e-02 8.39e-01 5.82e-01
Sensory processing of sound 52 5.74e-01 7.04e-01 0.08460 0.083000 -1.65e-02 3.01e-01 8.37e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 7.67e-01 8.41e-01 0.08440 0.022000 -8.14e-02 8.49e-01 4.81e-01
Frs2-mediated activation 12 8.81e-01 9.18e-01 0.08430 -0.074900 3.87e-02 6.53e-01 8.17e-01
RHOG GTPase cycle 71 4.73e-01 6.20e-01 0.08430 0.024600 -8.06e-02 7.20e-01 2.40e-01
HDACs deacetylate histones 36 6.83e-01 7.81e-01 0.08420 0.006180 -8.40e-02 9.49e-01 3.83e-01
Pre-NOTCH Expression and Processing 54 5.66e-01 6.98e-01 0.08360 -0.044600 -7.07e-02 5.71e-01 3.69e-01
Signaling by PDGFR in disease 20 8.11e-01 8.76e-01 0.08350 -0.082500 -1.28e-02 5.23e-01 9.21e-01
Fanconi Anemia Pathway 35 6.97e-01 7.90e-01 0.08330 -0.072200 4.15e-02 4.60e-01 6.71e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 6.63e-01 7.71e-01 0.08290 -0.082400 9.44e-03 3.68e-01 9.18e-01
Signaling by RAS mutants 40 6.63e-01 7.71e-01 0.08290 -0.082400 9.44e-03 3.68e-01 9.18e-01
Signaling by moderate kinase activity BRAF mutants 40 6.63e-01 7.71e-01 0.08290 -0.082400 9.44e-03 3.68e-01 9.18e-01
Signaling downstream of RAS mutants 40 6.63e-01 7.71e-01 0.08290 -0.082400 9.44e-03 3.68e-01 9.18e-01
SUMOylation of chromatin organization proteins 57 5.60e-01 6.93e-01 0.08280 -0.079100 2.44e-02 3.02e-01 7.50e-01
Positive epigenetic regulation of rRNA expression 52 5.90e-01 7.16e-01 0.08250 0.080800 -1.68e-02 3.14e-01 8.34e-01
DNA Damage Bypass 46 6.25e-01 7.41e-01 0.08250 0.078100 2.66e-02 3.60e-01 7.55e-01
DNA strand elongation 31 7.36e-01 8.21e-01 0.08120 0.005000 -8.11e-02 9.62e-01 4.35e-01
Nephrin family interactions 18 8.41e-01 8.94e-01 0.08030 0.079500 -1.15e-02 5.59e-01 9.33e-01
Signaling by ERBB2 in Cancer 24 7.94e-01 8.65e-01 0.08000 0.016000 7.84e-02 8.92e-01 5.06e-01
Mitotic Prophase 88 4.34e-01 5.86e-01 0.07930 -0.056200 -5.60e-02 3.63e-01 3.64e-01
Semaphorin interactions 62 5.62e-01 6.95e-01 0.07850 -0.056900 -5.42e-02 4.39e-01 4.61e-01
Interleukin-37 signaling 20 8.33e-01 8.90e-01 0.07850 -0.044500 6.47e-02 7.31e-01 6.16e-01
Processing of Capped Intronless Pre-mRNA 29 7.66e-01 8.41e-01 0.07850 -0.077000 1.50e-02 4.73e-01 8.88e-01
Prostacyclin signalling through prostacyclin receptor 14 8.78e-01 9.16e-01 0.07830 -0.047600 -6.22e-02 7.58e-01 6.87e-01
Regulation of PLK1 Activity at G2/M Transition 85 4.65e-01 6.15e-01 0.07790 0.072300 -2.89e-02 2.49e-01 6.45e-01
ISG15 antiviral mechanism 71 5.30e-01 6.71e-01 0.07780 -0.059900 4.96e-02 3.83e-01 4.70e-01
ADP signalling through P2Y purinoceptor 12 16 8.66e-01 9.08e-01 0.07710 0.070800 3.05e-02 6.24e-01 8.33e-01
G alpha (s) signalling events 83 4.77e-01 6.25e-01 0.07700 -0.061800 -4.60e-02 3.31e-01 4.70e-01
Epigenetic regulation of gene expression 133 3.09e-01 4.70e-01 0.07690 0.009900 7.63e-02 8.44e-01 1.29e-01
Regulation of beta-cell development 19 8.48e-01 8.97e-01 0.07630 -0.062600 4.36e-02 6.37e-01 7.42e-01
RHOC GTPase cycle 70 5.44e-01 6.82e-01 0.07620 0.008740 7.57e-02 8.99e-01 2.74e-01
Deadenylation of mRNA 22 8.27e-01 8.87e-01 0.07610 -0.009570 7.55e-02 9.38e-01 5.40e-01
Cell-extracellular matrix interactions 18 8.55e-01 9.02e-01 0.07590 -0.048100 -5.86e-02 7.24e-01 6.67e-01
IKK complex recruitment mediated by RIP1 23 8.22e-01 8.85e-01 0.07560 0.030400 -6.93e-02 8.01e-01 5.65e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 6.70e-01 7.75e-01 0.07560 0.073300 -1.85e-02 3.85e-01 8.26e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 6.15e-01 7.33e-01 0.07520 0.059700 4.57e-02 4.35e-01 5.51e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 6.15e-01 7.33e-01 0.07520 0.059700 4.57e-02 4.35e-01 5.51e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 6.15e-01 7.33e-01 0.07520 0.059700 4.57e-02 4.35e-01 5.51e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 6.15e-01 7.33e-01 0.07520 0.059700 4.57e-02 4.35e-01 5.51e-01
Signaling by NOTCH1 in Cancer 57 6.15e-01 7.33e-01 0.07520 0.059700 4.57e-02 4.35e-01 5.51e-01
Viral Messenger RNA Synthesis 44 6.89e-01 7.84e-01 0.07520 -0.074300 -1.15e-02 3.94e-01 8.95e-01
RHOB GTPase cycle 66 5.71e-01 7.02e-01 0.07510 0.043900 6.09e-02 5.37e-01 3.92e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 7.37e-01 8.21e-01 0.07460 0.056800 -4.84e-02 5.50e-01 6.10e-01
Neuronal System 260 1.20e-01 2.41e-01 0.07440 0.010200 -7.37e-02 7.77e-01 4.10e-02
FLT3 Signaling 36 7.40e-01 8.22e-01 0.07440 -0.044600 -5.95e-02 6.43e-01 5.37e-01
RNA Polymerase III Abortive And Retractive Initiation 41 7.19e-01 8.09e-01 0.07360 0.065900 -3.28e-02 4.65e-01 7.16e-01
RNA Polymerase III Transcription 41 7.19e-01 8.09e-01 0.07360 0.065900 -3.28e-02 4.65e-01 7.16e-01
Cell junction organization 88 4.94e-01 6.41e-01 0.07360 0.047800 -5.59e-02 4.38e-01 3.65e-01
Signaling by Non-Receptor Tyrosine Kinases 51 6.69e-01 7.74e-01 0.07280 0.028000 -6.72e-02 7.29e-01 4.06e-01
Signaling by PTK6 51 6.69e-01 7.74e-01 0.07280 0.028000 -6.72e-02 7.29e-01 4.06e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 8.62e-01 9.04e-01 0.07260 0.053800 -4.89e-02 6.85e-01 7.12e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 8.62e-01 9.04e-01 0.07260 0.053800 -4.89e-02 6.85e-01 7.12e-01
Removal of the Flap Intermediate 14 8.95e-01 9.28e-01 0.07260 0.005520 7.24e-02 9.72e-01 6.39e-01
Arachidonic acid metabolism 36 7.56e-01 8.34e-01 0.07230 -0.067200 2.65e-02 4.85e-01 7.83e-01
Visual phototransduction 58 6.39e-01 7.53e-01 0.07210 0.068600 -2.23e-02 3.66e-01 7.70e-01
Nonhomologous End-Joining (NHEJ) 34 7.68e-01 8.41e-01 0.07210 -0.005130 7.19e-02 9.59e-01 4.68e-01
Metabolism of non-coding RNA 53 6.67e-01 7.73e-01 0.07140 0.011000 7.05e-02 8.90e-01 3.75e-01
snRNP Assembly 53 6.67e-01 7.73e-01 0.07140 0.011000 7.05e-02 8.90e-01 3.75e-01
HATs acetylate histones 82 5.37e-01 6.78e-01 0.07130 0.071300 1.31e-03 2.65e-01 9.84e-01
Signaling by FGFR1 in disease 32 7.83e-01 8.55e-01 0.07130 0.069100 1.75e-02 4.99e-01 8.64e-01
Platelet homeostasis 69 5.95e-01 7.18e-01 0.07090 -0.008410 -7.04e-02 9.04e-01 3.12e-01
ADORA2B mediated anti-inflammatory cytokines production 35 7.68e-01 8.41e-01 0.07070 -0.047700 -5.22e-02 6.26e-01 5.93e-01
Vasopressin regulates renal water homeostasis via Aquaporins 33 7.81e-01 8.54e-01 0.07070 0.070600 2.06e-03 4.83e-01 9.84e-01
E2F mediated regulation of DNA replication 21 8.59e-01 9.04e-01 0.06960 -0.009280 6.89e-02 9.41e-01 5.85e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 9.18e-01 9.45e-01 0.06930 0.063200 -2.86e-02 7.05e-01 8.64e-01
Triglyceride catabolism 16 8.93e-01 9.26e-01 0.06840 -0.051700 -4.47e-02 7.20e-01 7.57e-01
FGFR1 mutant receptor activation 25 8.41e-01 8.94e-01 0.06830 0.023500 -6.41e-02 8.39e-01 5.79e-01
Mitochondrial calcium ion transport 21 8.68e-01 9.08e-01 0.06740 0.059000 -3.26e-02 6.40e-01 7.96e-01
Regulation of HSF1-mediated heat shock response 78 5.92e-01 7.16e-01 0.06740 0.047100 -4.82e-02 4.73e-01 4.62e-01
Rab regulation of trafficking 118 4.64e-01 6.13e-01 0.06600 -0.064900 -1.21e-02 2.24e-01 8.21e-01
RHO GTPases Activate WASPs and WAVEs 35 7.95e-01 8.65e-01 0.06600 -0.060500 -2.64e-02 5.36e-01 7.87e-01
RNA Polymerase I Transcription Initiation 47 7.38e-01 8.21e-01 0.06580 0.065800 -2.07e-03 4.35e-01 9.80e-01
Aquaporin-mediated transport 35 7.99e-01 8.68e-01 0.06570 0.062200 -2.12e-02 5.24e-01 8.28e-01
Organelle biogenesis and maintenance 271 1.81e-01 3.24e-01 0.06560 0.061300 -2.34e-02 8.30e-02 5.08e-01
Impaired BRCA2 binding to RAD51 33 8.09e-01 8.74e-01 0.06530 0.042700 4.94e-02 6.71e-01 6.24e-01
Regulation of lipid metabolism by PPARalpha 106 5.16e-01 6.59e-01 0.06500 -0.047000 4.49e-02 4.03e-01 4.25e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 87 5.80e-01 7.08e-01 0.06490 0.018400 -6.23e-02 7.67e-01 3.16e-01
Amplification of signal from the kinetochores 87 5.80e-01 7.08e-01 0.06490 0.018400 -6.23e-02 7.67e-01 3.16e-01
Signaling by EGFR in Cancer 22 8.70e-01 9.09e-01 0.06480 -0.058700 -2.76e-02 6.34e-01 8.23e-01
VEGFR2 mediated vascular permeability 27 8.45e-01 8.96e-01 0.06470 -0.058300 2.80e-02 6.00e-01 8.01e-01
Signaling by ERBB4 51 7.28e-01 8.17e-01 0.06450 -0.064400 -2.80e-03 4.26e-01 9.72e-01
SUMOylation of transcription cofactors 44 7.62e-01 8.39e-01 0.06420 -0.000832 -6.42e-02 9.92e-01 4.61e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.78e-01 9.16e-01 0.06420 -0.018100 -6.16e-02 8.86e-01 6.25e-01
Metabolism of water-soluble vitamins and cofactors 108 5.20e-01 6.62e-01 0.06350 -0.035100 -5.29e-02 5.29e-01 3.42e-01
rRNA processing in the mitochondrion 10 9.42e-01 9.61e-01 0.06340 0.032600 -5.44e-02 8.59e-01 7.66e-01
DNA Repair 280 1.91e-01 3.37e-01 0.06330 0.005060 -6.31e-02 8.84e-01 6.97e-02
Potassium Channels 50 7.46e-01 8.27e-01 0.06280 0.015900 -6.07e-02 8.46e-01 4.58e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 30 8.39e-01 8.94e-01 0.06260 0.014500 -6.10e-02 8.91e-01 5.63e-01
Metabolism of lipids 598 3.66e-02 1.00e-01 0.06190 -0.061500 6.87e-03 1.05e-02 7.75e-01
Signaling by Retinoic Acid 35 8.19e-01 8.83e-01 0.06170 -0.061300 6.67e-03 5.30e-01 9.46e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 9.33e-01 9.55e-01 0.06170 0.055400 2.71e-02 7.40e-01 8.71e-01
Mitotic Spindle Checkpoint 104 5.57e-01 6.92e-01 0.06170 0.031400 -5.31e-02 5.81e-01 3.50e-01
Gene Silencing by RNA 78 6.54e-01 7.65e-01 0.06010 0.045500 3.93e-02 4.88e-01 5.49e-01
Transcriptional regulation of white adipocyte differentiation 80 6.48e-01 7.60e-01 0.06000 -0.033400 -4.99e-02 6.05e-01 4.41e-01
Activation of kainate receptors upon glutamate binding 23 8.84e-01 9.19e-01 0.06000 0.038400 -4.62e-02 7.50e-01 7.02e-01
tRNA processing in the nucleus 59 7.30e-01 8.17e-01 0.06000 -0.037300 4.70e-02 6.21e-01 5.32e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 8.93e-01 9.26e-01 0.05990 -0.056200 -2.06e-02 6.56e-01 8.70e-01
HDR through Single Strand Annealing (SSA) 35 8.32e-01 8.90e-01 0.05940 -0.024200 5.42e-02 8.04e-01 5.79e-01
Cytochrome P450 - arranged by substrate type 32 8.48e-01 8.97e-01 0.05890 -0.045000 3.80e-02 6.59e-01 7.10e-01
MAP2K and MAPK activation 35 8.36e-01 8.93e-01 0.05870 -0.050700 2.97e-02 6.04e-01 7.61e-01
Netrin-1 signaling 41 8.08e-01 8.74e-01 0.05870 0.036100 4.63e-02 6.89e-01 6.08e-01
RHOA GTPase cycle 143 4.82e-01 6.29e-01 0.05870 -0.057300 1.28e-02 2.37e-01 7.92e-01
RNA Polymerase II Transcription Termination 66 7.16e-01 8.07e-01 0.05850 -0.042500 4.02e-02 5.50e-01 5.72e-01
PPARA activates gene expression 104 6.00e-01 7.22e-01 0.05760 -0.040400 4.11e-02 4.77e-01 4.69e-01
ERK/MAPK targets 22 8.97e-01 9.30e-01 0.05760 0.031700 -4.81e-02 7.97e-01 6.96e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.84e-01 9.19e-01 0.05720 -0.025100 -5.14e-02 8.28e-01 6.56e-01
Signaling by ERBB2 TMD/JMD mutants 20 9.09e-01 9.40e-01 0.05650 -0.056400 -3.43e-03 6.63e-01 9.79e-01
RAC2 GTPase cycle 85 6.75e-01 7.77e-01 0.05590 -0.045800 3.19e-02 4.65e-01 6.11e-01
Glucagon-type ligand receptors 16 9.28e-01 9.52e-01 0.05580 0.015900 -5.35e-02 9.12e-01 7.11e-01
Pre-NOTCH Transcription and Translation 38 8.39e-01 8.94e-01 0.05540 0.046900 2.94e-02 6.17e-01 7.54e-01
Loss of Nlp from mitotic centrosomes 67 7.40e-01 8.22e-01 0.05480 0.053200 1.30e-02 4.52e-01 8.54e-01
Loss of proteins required for interphase microtubule organization from the centrosome 67 7.40e-01 8.22e-01 0.05480 0.053200 1.30e-02 4.52e-01 8.54e-01
GABA receptor activation 39 8.40e-01 8.94e-01 0.05470 0.053500 -1.17e-02 5.63e-01 9.00e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 9.27e-01 9.51e-01 0.05470 -0.006710 5.42e-02 9.62e-01 6.99e-01
Metabolism of porphyrins 21 9.11e-01 9.42e-01 0.05460 0.026600 -4.77e-02 8.33e-01 7.05e-01
Mitotic Prometaphase 188 4.44e-01 5.94e-01 0.05420 0.041100 -3.53e-02 3.32e-01 4.05e-01
Nuclear Receptor transcription pathway 39 8.44e-01 8.96e-01 0.05400 0.051200 -1.71e-02 5.80e-01 8.53e-01
Regulation of Expression and Function of Type II Classical Cadherins 29 8.82e-01 9.18e-01 0.05400 0.015100 -5.18e-02 8.88e-01 6.29e-01
Regulation of Homotypic Cell-Cell Adhesion 29 8.82e-01 9.18e-01 0.05400 0.015100 -5.18e-02 8.88e-01 6.29e-01
SUMOylation of RNA binding proteins 47 8.17e-01 8.81e-01 0.05380 -0.051500 1.53e-02 5.41e-01 8.56e-01
Metabolism of steroids 120 6.06e-01 7.27e-01 0.05310 0.014800 -5.10e-02 7.79e-01 3.35e-01
Extra-nuclear estrogen signaling 66 7.59e-01 8.36e-01 0.05290 -0.001050 -5.29e-02 9.88e-01 4.58e-01
HDR through Homologous Recombination (HRR) 65 7.68e-01 8.41e-01 0.05210 -0.002280 5.21e-02 9.75e-01 4.68e-01
Processive synthesis on the lagging strand 15 9.42e-01 9.61e-01 0.05180 -0.020300 4.77e-02 8.92e-01 7.49e-01
SUMO E3 ligases SUMOylate target proteins 162 5.41e-01 6.81e-01 0.05070 -0.041300 2.95e-02 3.65e-01 5.17e-01
Centrosome maturation 79 7.49e-01 8.28e-01 0.04960 0.049500 -1.35e-03 4.47e-01 9.83e-01
Recruitment of mitotic centrosome proteins and complexes 79 7.49e-01 8.28e-01 0.04960 0.049500 -1.35e-03 4.47e-01 9.83e-01
Tie2 Signaling 15 9.47e-01 9.64e-01 0.04890 -0.035500 -3.36e-02 8.12e-01 8.22e-01
Signaling by ERBB2 KD Mutants 23 9.22e-01 9.47e-01 0.04870 0.001180 4.87e-02 9.92e-01 6.86e-01
HDR through MMEJ (alt-NHEJ) 12 9.60e-01 9.71e-01 0.04790 -0.016300 4.50e-02 9.22e-01 7.87e-01
DNA Double-Strand Break Repair 129 6.44e-01 7.58e-01 0.04770 -0.028600 -3.81e-02 5.75e-01 4.55e-01
Signaling by ERBB2 47 8.56e-01 9.02e-01 0.04720 0.017200 -4.39e-02 8.39e-01 6.03e-01
Transcriptional Regulation by MECP2 48 8.55e-01 9.02e-01 0.04690 0.029400 -3.65e-02 7.24e-01 6.62e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 9.56e-01 9.68e-01 0.04630 -0.011400 -4.49e-02 9.41e-01 7.71e-01
Processing of Capped Intron-Containing Pre-mRNA 278 4.14e-01 5.67e-01 0.04630 0.044600 1.24e-02 2.02e-01 7.23e-01
Endogenous sterols 20 9.37e-01 9.58e-01 0.04630 -0.038000 -2.64e-02 7.69e-01 8.38e-01
Tight junction interactions 17 9.48e-01 9.65e-01 0.04550 0.040300 2.11e-02 7.74e-01 8.80e-01
Activation of ATR in response to replication stress 31 9.12e-01 9.42e-01 0.04460 0.008570 -4.37e-02 9.34e-01 6.73e-01
Cell-Cell communication 116 7.20e-01 8.10e-01 0.04380 0.033000 -2.89e-02 5.40e-01 5.91e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.44e-01 9.62e-01 0.04270 0.006070 -4.23e-02 9.62e-01 7.37e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.44e-01 9.62e-01 0.04270 0.006070 -4.23e-02 9.62e-01 7.37e-01
RHOJ GTPase cycle 53 8.67e-01 9.08e-01 0.04260 -0.014400 4.01e-02 8.56e-01 6.14e-01
Termination of translesion DNA synthesis 31 9.20e-01 9.46e-01 0.04230 0.041900 6.41e-03 6.87e-01 9.51e-01
Phase I - Functionalization of compounds 65 8.42e-01 8.94e-01 0.04200 0.020400 3.67e-02 7.76e-01 6.09e-01
Postmitotic nuclear pore complex (NPC) reformation 27 9.31e-01 9.53e-01 0.04180 -0.032700 -2.60e-02 7.69e-01 8.15e-01
Glycogen breakdown (glycogenolysis) 13 9.67e-01 9.76e-01 0.04130 0.009750 -4.01e-02 9.51e-01 8.02e-01
Prolonged ERK activation events 14 9.68e-01 9.76e-01 0.03950 0.001880 3.95e-02 9.90e-01 7.98e-01
RHOF GTPase cycle 39 9.16e-01 9.44e-01 0.03900 -0.034200 1.89e-02 7.12e-01 8.38e-01
Signaling by NOTCH1 72 8.48e-01 8.97e-01 0.03900 0.026300 2.88e-02 7.00e-01 6.73e-01
Homology Directed Repair 100 8.06e-01 8.74e-01 0.03790 -0.016400 -3.42e-02 7.77e-01 5.55e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 9.54e-01 9.68e-01 0.03780 -0.025200 2.82e-02 8.38e-01 8.19e-01
Glyoxylate metabolism and glycine degradation 23 9.54e-01 9.68e-01 0.03730 0.030200 -2.18e-02 8.02e-01 8.56e-01
Inositol phosphate metabolism 42 9.18e-01 9.45e-01 0.03670 -0.033000 -1.61e-02 7.12e-01 8.57e-01
Signaling by NOTCH2 31 9.40e-01 9.60e-01 0.03650 -0.000942 -3.65e-02 9.93e-01 7.25e-01
Regulation of CDH11 Expression and Function 27 9.49e-01 9.65e-01 0.03600 -0.035800 -3.97e-03 7.48e-01 9.72e-01
Synthesis of IP3 and IP4 in the cytosol 22 9.58e-01 9.70e-01 0.03590 0.029200 2.09e-02 8.13e-01 8.66e-01
SUMOylation 168 7.31e-01 8.17e-01 0.03560 -0.029400 2.01e-02 5.12e-01 6.54e-01
RHO GTPase cycle 418 4.73e-01 6.20e-01 0.03520 -0.019900 2.90e-02 4.87e-01 3.11e-01
G2/M DNA damage checkpoint 57 9.02e-01 9.34e-01 0.03490 0.032100 -1.37e-02 6.75e-01 8.58e-01
Deadenylation-dependent mRNA decay 50 9.16e-01 9.44e-01 0.03430 0.010100 -3.28e-02 9.01e-01 6.88e-01
RAB GEFs exchange GTP for GDP on RABs 86 8.59e-01 9.04e-01 0.03430 -0.029400 -1.75e-02 6.37e-01 7.79e-01
Transcriptional regulation by small RNAs 53 9.18e-01 9.45e-01 0.03290 0.026200 -2.00e-02 7.42e-01 8.01e-01
Biological oxidations 137 8.04e-01 8.73e-01 0.03280 0.020100 -2.60e-02 6.85e-01 6.00e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.82e-01 9.87e-01 0.03280 0.024400 2.19e-02 8.88e-01 9.00e-01
Signaling by NOTCH3 46 9.30e-01 9.53e-01 0.03260 0.017700 -2.74e-02 8.35e-01 7.48e-01
Generic Transcription Pathway 1079 2.01e-01 3.49e-01 0.03240 0.028000 1.64e-02 1.24e-01 3.67e-01
Signaling by Rho GTPases 598 4.37e-01 5.89e-01 0.03090 0.002170 -3.09e-02 9.28e-01 1.99e-01
RNA Polymerase II Transcription 1197 2.02e-01 3.50e-01 0.03090 0.027400 1.43e-02 1.14e-01 4.10e-01
tRNA processing 109 8.62e-01 9.04e-01 0.03020 0.021700 2.09e-02 6.96e-01 7.06e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 613 4.57e-01 6.06e-01 0.02970 -0.000624 -2.97e-02 9.79e-01 2.11e-01
AURKA Activation by TPX2 70 9.13e-01 9.43e-01 0.02940 0.028600 6.70e-03 6.79e-01 9.23e-01
Gene expression (Transcription) 1356 1.99e-01 3.46e-01 0.02930 0.019700 2.17e-02 2.29e-01 1.85e-01
Dual Incision in GG-NER 41 9.55e-01 9.68e-01 0.02740 0.024800 1.16e-02 7.83e-01 8.98e-01
Phosphorylation of the APC/C 20 9.78e-01 9.85e-01 0.02720 -0.013000 -2.40e-02 9.20e-01 8.53e-01
Signaling by Nuclear Receptors 212 8.30e-01 8.89e-01 0.02450 0.007070 -2.34e-02 8.59e-01 5.57e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.82e-01 9.87e-01 0.02440 0.014700 1.95e-02 9.09e-01 8.80e-01
Class I peroxisomal membrane protein import 19 9.84e-01 9.88e-01 0.02400 0.011200 -2.12e-02 9.33e-01 8.73e-01
RAC3 GTPase cycle 87 9.31e-01 9.53e-01 0.02350 -0.022700 -5.79e-03 7.14e-01 9.26e-01
Nicotinate metabolism 27 9.80e-01 9.86e-01 0.02240 -0.022300 1.87e-03 8.41e-01 9.87e-01
RHOH GTPase cycle 32 9.77e-01 9.85e-01 0.02180 0.006750 2.07e-02 9.47e-01 8.39e-01
p130Cas linkage to MAPK signaling for integrins 12 9.94e-01 9.96e-01 0.01830 -0.011100 -1.46e-02 9.47e-01 9.30e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 9.88e-01 9.92e-01 0.01600 0.007110 1.44e-02 9.46e-01 8.92e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 94 9.65e-01 9.75e-01 0.01600 -0.009090 -1.31e-02 8.79e-01 8.26e-01
Fatty acid metabolism 140 9.55e-01 9.68e-01 0.01490 -0.004020 1.44e-02 9.35e-01 7.69e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.95e-01 9.97e-01 0.01280 0.012500 -2.57e-03 9.23e-01 9.84e-01
MTOR signalling 40 9.91e-01 9.94e-01 0.01230 -0.008440 -8.99e-03 9.26e-01 9.22e-01
Chromatin modifying enzymes 203 9.67e-01 9.76e-01 0.01050 -0.002860 -1.01e-02 9.44e-01 8.04e-01
Chromatin organization 203 9.67e-01 9.76e-01 0.01050 -0.002860 -1.01e-02 9.44e-01 8.04e-01
Nicotinamide salvaging 16 9.99e-01 9.99e-01 0.00777 0.001940 7.52e-03 9.89e-01 9.58e-01
Phase 2 - plateau phase 10 9.99e-01 9.99e-01 0.00740 0.007160 1.86e-03 9.69e-01 9.92e-01


Detailed Gene set reports


Peptide chain elongation

Peptide chain elongation
metric value
setSize 87
pMANOVA 7.78e-50
p.adjustMANOVA 2.35e-47
s.dist 0.934
s.OAvRCA 0.74
s.OAvRCR -0.57
p.OAvRCA 6.05e-33
p.OAvRCR 3.91e-20




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260
RPS11 7451 -5162

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EEF1A1 7502 -3600
EEF2 2239 -7487
FAU 7475 -5933
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
metric value
setSize 36
pMANOVA 5.1e-21
p.adjustMANOVA 1.97e-19
s.dist 0.934
s.OAvRCA 0.761
s.OAvRCR -0.542
p.OAvRCA 2.71e-15
p.OAvRCR 1.83e-08




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPS3 6521 -6817
FAU 7475 -5933
RPS29 5992 -7207
RPS5 7237 -5913
RPSA 6976 -6059
RPS8 6878 -5930
RPS11 7451 -5162
RPS15 6491 -5857
RPS27 6180 -6113
RPS28 5949 -6045
RPS6 7144 -5016
RPS2 4552 -7639
RPS12 5792 -5764
RPS17 6645 -4893
RPS18 5272 -6135
RPS15A 7262 -4395
RPS16 5840 -5395
RPS21 5390 -5748
RPS10 7071 -4239

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EEF1A1 7502 -3600
FAU 7475 -5933
HNRNPA1 6486 -3942
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
metric value
setSize 92
pMANOVA 2.53e-52
p.adjustMANOVA 3.71e-49
s.dist 0.931
s.OAvRCA 0.731
s.OAvRCR -0.577
p.OAvRCA 6.43e-34
p.OAvRCR 1.11e-21




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
EEF1B2 7747 -5419
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
EEF1G 5995 -6439

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EEF1A1 7502 -3600
EEF1A1P5 6616 -4396
EEF1A2 -4765 -8393
EEF1B2 7747 -5419
EEF1D 7241 -4710
EEF1G 5995 -6439
EEF2 2239 -7487
FAU 7475 -5933
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



Viral mRNA Translation

Viral mRNA Translation
metric value
setSize 87
pMANOVA 4.69e-48
p.adjustMANOVA 8.61e-46
s.dist 0.917
s.OAvRCA 0.725
s.OAvRCR -0.562
p.OAvRCA 1.17e-31
p.OAvRCR 1.27e-19




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260
RPS11 7451 -5162

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
DNAJC3 -4255 -3134
FAU 7475 -5933
GRSF1 3027 -2287
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
metric value
setSize 99
pMANOVA 4.01e-51
p.adjustMANOVA 2.33e-48
s.dist 0.887
s.OAvRCA 0.705
s.OAvRCR -0.538
p.OAvRCA 5.9e-34
p.OAvRCR 2.01e-20




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
EIF3I 6042 -7461
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
FAU 7475 -5933
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



Selenocysteine synthesis

Selenocysteine synthesis
metric value
setSize 91
pMANOVA 2.61e-46
p.adjustMANOVA 3.49e-44
s.dist 0.88
s.OAvRCA 0.707
s.OAvRCR -0.525
p.OAvRCA 1.9e-31
p.OAvRCR 4.65e-18




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260
RPS11 7451 -5162

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EEFSEC 4093 -583
FAU 7475 -5933
PSTK 2417 -1921
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SARS1 3658 -6437
SECISBP2 -726 7030
SEPHS2 -2066 -2667
SEPSECS 882 7566
UBA52 5424 -6595



Eukaryotic Translation Termination

Eukaryotic Translation Termination
metric value
setSize 91
pMANOVA 8.08e-46
p.adjustMANOVA 9.89e-44
s.dist 0.876
s.OAvRCA 0.682
s.OAvRCR -0.549
p.OAvRCA 2.03e-29
p.OAvRCR 1.33e-19




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260
RPS11 7451 -5162

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
APEH -3403 -4729
ETF1 1413 -2712
FAU 7475 -5933
GSPT1 -2979 -7496
GSPT2 -1852 -212
N6AMT1 -7752 4191
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
TRMT112 4563 -3995
UBA52 5424 -6595



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 93
pMANOVA 3.46e-45
p.adjustMANOVA 3.91e-43
s.dist 0.86
s.OAvRCA 0.673
s.OAvRCR -0.536
p.OAvRCA 2.81e-29
p.OAvRCR 4.21e-19




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260
RPS11 7451 -5162

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF4G1 -5022 -6698
ETF1 1413 -2712
FAU 7475 -5933
GSPT1 -2979 -7496
GSPT2 -1852 -212
NCBP1 243 1664
NCBP2 1850 2484
PABPC1 3634 2755
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595
UPF1 -3243 -3730



L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 109
pMANOVA 4.75e-51
p.adjustMANOVA 2.33e-48
s.dist 0.845
s.OAvRCA 0.664
s.OAvRCR -0.524
p.OAvRCA 4.22e-33
p.OAvRCR 3.29e-21




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
EIF3I 6042 -7461
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
EIF2S2 5902 -6996
RPS8 6878 -5930

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4G1 -5022 -6698
EIF4H -336 -6561
FAU 7475 -5933
PABPC1 3634 2755
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 110
pMANOVA 7.99e-50
p.adjustMANOVA 2.35e-47
s.dist 0.831
s.OAvRCA 0.652
s.OAvRCR -0.516
p.OAvRCA 3e-32
p.OAvRCR 8.03e-21




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
EIF3I 6042 -7461
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
EIF2S2 5902 -6996
RPS8 6878 -5930

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4G1 -5022 -6698
EIF4H -336 -6561
EIF5 -4777 1508
EIF5B 2908 3613
FAU 7475 -5933
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
metric value
setSize 99
pMANOVA 9.95e-45
p.adjustMANOVA 1.04e-42
s.dist 0.83
s.OAvRCA 0.652
s.OAvRCR -0.513
p.OAvRCA 3.07e-29
p.OAvRCR 1.12e-18




Top 20 genes
Gene OAvRCA OAvRCR
ATF3 8149 -8369
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
EIF2S2 5902 -6996
RPS8 6878 -5930

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ASNS -2317 4541
ATF2 -1013 4075
ATF3 8149 -8369
ATF4 3076 -7425
CEBPB -1115 -6233
CEBPG 7976 3583
DDIT3 -2585 -2929
EIF2AK4 1091 5900
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
FAU 7475 -5933
GCN1 -7022 899
IMPACT -670 2348
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
TRIB3 -6043 -5393
UBA52 5424 -6595



Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 51
pMANOVA 5.47e-23
p.adjustMANOVA 2.51e-21
s.dist 0.822
s.OAvRCA 0.656
s.OAvRCR -0.495
p.OAvRCA 4.84e-16
p.OAvRCR 9.59e-10




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
EIF3I 6042 -7461
RPS3 6521 -6817
FAU 7475 -5933
RPS29 5992 -7207
RPS5 7237 -5913
RPSA 6976 -6059
EIF2S2 5902 -6996
RPS8 6878 -5930
RPS11 7451 -5162
RPS15 6491 -5857
RPS27 6180 -6113
RPS28 5949 -6045
RPS6 7144 -5016
RPS2 4552 -7639
EIF3H 6933 -4969
RPS12 5792 -5764
RPS17 6645 -4893
RPS18 5272 -6135
RPS15A 7262 -4395

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
FAU 7475 -5933
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059



Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
metric value
setSize 117
pMANOVA 2.09e-48
p.adjustMANOVA 4.38e-46
s.dist 0.795
s.OAvRCA 0.612
s.OAvRCR -0.507
p.OAvRCA 2.63e-30
p.OAvRCR 2.45e-21




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
EIF3I 6042 -7461
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
EIF2S2 5902 -6996
RPS8 6878 -5930

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2B1 -6291 -1711
EIF2B2 3390 -5835
EIF2B3 4632 -5629
EIF2B4 -85 -5117
EIF2B5 -4184 989
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4EBP1 -2988 -7486
EIF4G1 -5022 -6698
EIF4H -336 -6561
EIF5 -4777 1508
EIF5B 2908 3613
FAU 7475 -5933
PABPC1 3634 2755
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
metric value
setSize 117
pMANOVA 2.09e-48
p.adjustMANOVA 4.38e-46
s.dist 0.795
s.OAvRCA 0.612
s.OAvRCR -0.507
p.OAvRCA 2.63e-30
p.OAvRCR 2.45e-21




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
EIF3I 6042 -7461
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
EIF2S2 5902 -6996
RPS8 6878 -5930

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2B1 -6291 -1711
EIF2B2 3390 -5835
EIF2B3 4632 -5629
EIF2B4 -85 -5117
EIF2B5 -4184 989
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4EBP1 -2988 -7486
EIF4G1 -5022 -6698
EIF4H -336 -6561
EIF5 -4777 1508
EIF5B 2908 3613
FAU 7475 -5933
PABPC1 3634 2755
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
UBA52 5424 -6595



SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
metric value
setSize 110
pMANOVA 2.4e-42
p.adjustMANOVA 2.21e-40
s.dist 0.766
s.OAvRCA 0.553
s.OAvRCR -0.53
p.OAvRCA 1.09e-23
p.OAvRCR 7.9e-22




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260
RPS11 7451 -5162

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
DDOST -5013 -7514
FAU 7475 -5933
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPN1 -2506 -7285
RPN2 -6980 -5567
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SEC11A 6397 -2829
SEC11C 2846 -280
SEC61A1 -7720 -7142
SEC61A2 -6813 5183
SEC61B 2089 -6984
SEC61G 83 -2797
SPCS1 1859 3058
SPCS2 497 -788
SPCS3 -3195 -1846
SRP14 1696 -846
SRP19 3665 753
SRP54 1950 -6893
SRP68 1459 -6914
SRP72 59 -904
SRP9 1595 5546
SRPRA -4251 -7740
SRPRB -3247 -7036
SSR1 -4054 -6100
SSR2 2503 -7982
SSR3 -1077 -5322
SSR4 -3872 -8243
TRAM1 -369 850
UBA52 5424 -6595



FCGR activation

FCGR activation
metric value
setSize 19
pMANOVA 5.24e-08
p.adjustMANOVA 6.75e-07
s.dist 0.765
s.OAvRCA -0.707
s.OAvRCR -0.29
p.OAvRCA 9.31e-08
p.OAvRCR 0.0285




Top 20 genes
Gene OAvRCA OAvRCR
IGLC1 -8252 -7392
CD247 -6601 -7827
FCGR1A -7854 -6096
SRC -5097 -7387
IGLC3 -8143 -4362
IGLC2 -7616 -4026
IGHG2 -6735 -4489
IGHG4 -8356 -3505
FGR -6734 -4034
IGHG3 -4780 -4954
IGHG1 -6652 -3227
FCGR2A -8013 -1057
IGKC -1103 -3954

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CD247 -6601 -7827
FCGR1A -7854 -6096
FCGR2A -8013 -1057
FCGR3A -7728 911
FGR -6734 -4034
FYN -1579 4417
HCK -7485 2260
IGHG1 -6652 -3227
IGHG2 -6735 -4489
IGHG3 -4780 -4954
IGHG4 -8356 -3505
IGKC -1103 -3954
IGLC1 -8252 -7392
IGLC2 -7616 -4026
IGLC3 -8143 -4362
LYN -4199 1229
SRC -5097 -7387
SYK -6900 6271
YES1 983 -1394



Translation initiation complex formation

Translation initiation complex formation
metric value
setSize 58
pMANOVA 1.73e-22
p.adjustMANOVA 7.71e-21
s.dist 0.762
s.OAvRCA 0.598
s.OAvRCR -0.472
p.OAvRCA 3.09e-15
p.OAvRCR 4.82e-10




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
EIF3I 6042 -7461
RPS3 6521 -6817
FAU 7475 -5933
RPS29 5992 -7207
RPS5 7237 -5913
RPSA 6976 -6059
EIF2S2 5902 -6996
RPS8 6878 -5930
RPS11 7451 -5162
RPS15 6491 -5857
RPS27 6180 -6113
RPS28 5949 -6045
RPS6 7144 -5016
RPS2 4552 -7639
EIF3H 6933 -4969
RPS12 5792 -5764
RPS17 6645 -4893
RPS18 5272 -6135
RPS15A 7262 -4395

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4G1 -5022 -6698
EIF4H -336 -6561
FAU 7475 -5933
PABPC1 3634 2755
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059



Selenoamino acid metabolism

Selenoamino acid metabolism
metric value
setSize 113
pMANOVA 6.2e-43
p.adjustMANOVA 6.07e-41
s.dist 0.761
s.OAvRCA 0.579
s.OAvRCR -0.494
p.OAvRCA 1.9e-26
p.OAvRCR 1.17e-19




Top 20 genes
Gene OAvRCA OAvRCR
NNMT 7322 -8357
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RPL4 7315 -5260

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
AHCY 5698 -6264
AIMP1 2103 4613
AIMP2 3443 -1305
CBS -3241 -5108
CTH 908 -4214
DARS1 1673 -4013
EEF1E1 1239 -2641
EEFSEC 4093 -583
EPRS1 1171 -6257
FAU 7475 -5933
GSR 807 -6529
HNMT -4441 7838
IARS1 -5346 -8067
INMT 6710 1202
KARS1 4970 -5752
LARS1 -4375 4086
MARS1 -5864 -5273
NNMT 7322 -8357
PAPSS1 -3687 -6630
PAPSS2 3495 -6520
PSTK 2417 -1921
QARS1 -1922 -958
RARS1 -1040 -2857
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SARS1 3658 -6437
SCLY -5111 -2830
SECISBP2 -726 7030
SEPHS2 -2066 -2667
SEPSECS 882 7566
TXNRD1 1948 -3007
UBA52 5424 -6595



Gluconeogenesis

Gluconeogenesis
metric value
setSize 27
pMANOVA 6.66e-11
p.adjustMANOVA 1.53e-09
s.dist 0.757
s.OAvRCA -0.507
s.OAvRCR -0.563
p.OAvRCA 5.09e-06
p.OAvRCR 4.18e-07




Top 20 genes
Gene OAvRCA OAvRCR
GPI -7315 -7981
PCK1 -7390 -7728
ALDOA -6739 -7959
PGK1 -5474 -7886
SLC25A11 -5352 -7528
ENO3 -7525 -4754
PC -4758 -7153
GOT2 -5650 -5881
TPI1 -4102 -8027
ENO1 -4270 -7571
ENO2 -3824 -6412
MDH2 -3433 -7103
MDH1 -4007 -5840
GAPDH -2692 -6783
G6PC3 -4808 -3486
ALDOC -1828 -8211
PGAM1 -1530 -8173
SLC25A12 -5512 -2157
SLC25A10 -1653 -6554
GOT1 -603 -6544

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ALDOA -6739 -7959
ALDOC -1828 -8211
ENO1 -4270 -7571
ENO2 -3824 -6412
ENO3 -7525 -4754
FBP1 -7157 155
G6PC3 -4808 -3486
GAPDH -2692 -6783
GOT1 -603 -6544
GOT2 -5650 -5881
GPI -7315 -7981
MDH1 -4007 -5840
MDH2 -3433 -7103
PC -4758 -7153
PCK1 -7390 -7728
PCK2 -6586 1960
PGAM1 -1530 -8173
PGK1 -5474 -7886
SLC25A1 2502 -7034
SLC25A10 -1653 -6554
SLC25A11 -5352 -7528
SLC25A12 -5512 -2157
SLC25A13 -4132 951
SLC37A1 4117 3037
SLC37A2 -8011 1830
SLC37A4 -7894 3083
TPI1 -4102 -8027



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
metric value
setSize 59
pMANOVA 2.15e-22
p.adjustMANOVA 9.27e-21
s.dist 0.754
s.OAvRCA 0.582
s.OAvRCR -0.48
p.OAvRCA 9.88e-15
p.OAvRCR 1.86e-10




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
EIF3I 6042 -7461
RPS3 6521 -6817
FAU 7475 -5933
RPS29 5992 -7207
RPS5 7237 -5913
RPSA 6976 -6059
EIF2S2 5902 -6996
RPS8 6878 -5930
RPS11 7451 -5162
RPS15 6491 -5857
RPS27 6180 -6113
RPS28 5949 -6045
RPS6 7144 -5016
RPS2 4552 -7639
EIF3H 6933 -4969
RPS12 5792 -5764
RPS17 6645 -4893
RPS18 5272 -6135
RPS15A 7262 -4395

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4EBP1 -2988 -7486
EIF4G1 -5022 -6698
EIF4H -336 -6561
FAU 7475 -5933
PABPC1 3634 2755
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059



Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
metric value
setSize 58
pMANOVA 8.44e-22
p.adjustMANOVA 3.54e-20
s.dist 0.75
s.OAvRCA 0.581
s.OAvRCR -0.475
p.OAvRCA 1.94e-14
p.OAvRCR 3.87e-10




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
EIF3I 6042 -7461
RPS3 6521 -6817
FAU 7475 -5933
RPS29 5992 -7207
RPS5 7237 -5913
RPSA 6976 -6059
EIF2S2 5902 -6996
RPS8 6878 -5930
RPS11 7451 -5162
RPS15 6491 -5857
RPS27 6180 -6113
RPS28 5949 -6045
RPS6 7144 -5016
RPS2 4552 -7639
EIF3H 6933 -4969
RPS12 5792 -5764
RPS17 6645 -4893
RPS18 5272 -6135
RPS15A 7262 -4395

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EIF1AX 4829 6771
EIF2S1 5088 -5253
EIF2S2 5902 -6996
EIF2S3 -1170 -1427
EIF3A 3632 -4294
EIF3B -3911 -6353
EIF3C 4158 -5975
EIF3D 4386 -1815
EIF3E 8004 -1083
EIF3F 1557 -4128
EIF3G 5554 -5694
EIF3H 6933 -4969
EIF3I 6042 -7461
EIF3J 124 -1513
EIF3K -162 -4106
EIF3L 6426 -3918
EIF3M 5205 1100
EIF4A1 -1973 -6648
EIF4A2 7164 1900
EIF4B 5869 -2965
EIF4E -1 -626
EIF4G1 -5022 -6698
EIF4H -336 -6561
EIF5 -4777 1508
FAU 7475 -5933
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059



Classical antibody-mediated complement activation

Classical antibody-mediated complement activation
metric value
setSize 13
pMANOVA 1.63e-05
p.adjustMANOVA 0.000109
s.dist 0.75
s.OAvRCA -0.713
s.OAvRCR -0.232
p.OAvRCA 8.45e-06
p.OAvRCR 0.148




Top 20 genes
Gene OAvRCA OAvRCR
IGLC1 -8252 -7392
IGLC3 -8143 -4362
IGLC2 -7616 -4026
IGHG2 -6735 -4489
IGHG4 -8356 -3505
IGHG3 -4780 -4954
IGHG1 -6652 -3227
C1S -3445 -4145
C1R -5584 -2104
IGKC -1103 -3954

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
C1QA -5527 5448
C1QB -5423 3690
C1QC -6248 6047
C1R -5584 -2104
C1S -3445 -4145
IGHG1 -6652 -3227
IGHG2 -6735 -4489
IGHG3 -4780 -4954
IGHG4 -8356 -3505
IGKC -1103 -3954
IGLC1 -8252 -7392
IGLC2 -7616 -4026
IGLC3 -8143 -4362



Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
metric value
setSize 21
pMANOVA 3.16e-08
p.adjustMANOVA 4.38e-07
s.dist 0.743
s.OAvRCA 0.355
s.OAvRCR -0.653
p.OAvRCA 0.00482
p.OAvRCR 2.21e-07




Top 20 genes
Gene OAvRCA OAvRCR
TUBB2A 7605 -7113
TCP1 6857 -6547
CCT4 6458 -6626
CCT7 4805 -7085
TUBB1 4041 -8376
TUBB2B 4387 -6813
CCT6A 7166 -4053
TUBB4B 4250 -5896
TUBA4A 2658 -8301
CCT6B 4659 -2851
TUBA1A 5134 -2541
TUBAL3 7849 -1465
CCT2 1628 -5653
TUBB6 2084 -4116
TUBA1B 1452 -3970
TUBA1C 752 -5469

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CCT2 1628 -5653
CCT3 -142 -7727
CCT4 6458 -6626
CCT5 -917 -3159
CCT6A 7166 -4053
CCT6B 4659 -2851
CCT7 4805 -7085
CCT8 -1621 -4654
TCP1 6857 -6547
TUBA1A 5134 -2541
TUBA1B 1452 -3970
TUBA1C 752 -5469
TUBA4A 2658 -8301
TUBA8 -5069 -7618
TUBAL3 7849 -1465
TUBB1 4041 -8376
TUBB2A 7605 -7113
TUBB2B 4387 -6813
TUBB3 -4423 -6596
TUBB4B 4250 -5896
TUBB6 2084 -4116



Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
metric value
setSize 13
pMANOVA 2.92e-05
p.adjustMANOVA 0.000186
s.dist 0.734
s.OAvRCA 0.252
s.OAvRCR -0.689
p.OAvRCA 0.115
p.OAvRCR 1.68e-05




Top 20 genes
Gene OAvRCA OAvRCR
TUBB2A 7605 -7113
TUBB1 4041 -8376
TUBB2B 4387 -6813
TUBB4B 4250 -5896
TUBA4A 2658 -8301
TUBA1A 5134 -2541
TUBAL3 7849 -1465
TUBB6 2084 -4116
TUBA1B 1452 -3970
TUBA1C 752 -5469

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
GJA1 -4867 -7860
TUBA1A 5134 -2541
TUBA1B 1452 -3970
TUBA1C 752 -5469
TUBA4A 2658 -8301
TUBA8 -5069 -7618
TUBAL3 7849 -1465
TUBB1 4041 -8376
TUBB2A 7605 -7113
TUBB2B 4387 -6813
TUBB3 -4423 -6596
TUBB4B 4250 -5896
TUBB6 2084 -4116



SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
metric value
setSize 49
pMANOVA 1.95e-17
p.adjustMANOVA 5.85e-16
s.dist 0.727
s.OAvRCA 0.608
s.OAvRCR -0.398
p.OAvRCA 1.7e-13
p.OAvRCR 1.47e-06




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPS3 6521 -6817
FAU 7475 -5933
RPS29 5992 -7207
RPS5 7237 -5913
RPSA 6976 -6059
SNRPD2 6390 -6452
RPS8 6878 -5930
RPS11 7451 -5162
RPS15 6491 -5857
RPS27 6180 -6113
RPS28 5949 -6045
RPS6 7144 -5016
RPS2 4552 -7639
RPS12 5792 -5764
RPS17 6645 -4893
RPS18 5272 -6135
RPS15A 7262 -4395
RPS16 5840 -5395
RPS21 5390 -5748

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
DDX20 -1394 5767
FAU 7475 -5933
GEMIN2 -200 -229
GEMIN4 -3820 4428
GEMIN5 7383 -2016
GEMIN6 1885 3439
GEMIN7 -5257 4894
GEMIN8 6272 3285
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SMN1 7503 4945
SNRPB 3985 -7247
SNRPD1 6978 -3338
SNRPD2 6390 -6452
SNRPD3 -518 -2788
SNRPE 5336 -2629
SNRPF -2029 -6244
SNRPG 33 -5153



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
metric value
setSize 113
pMANOVA 6.45e-39
p.adjustMANOVA 4.99e-37
s.dist 0.724
s.OAvRCA 0.561
s.OAvRCR -0.458
p.OAvRCA 6.39e-25
p.OAvRCR 4.17e-17




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RBM8A 5531 -7145
RPL4 7315 -5260

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CASC3 4184 -1259
DCP1A 2863 -1944
EIF4A3 360 -7269
EIF4G1 -5022 -6698
ETF1 1413 -2712
FAU 7475 -5933
GSPT1 -2979 -7496
GSPT2 -1852 -212
MAGOH 5002 -607
MAGOHB 2421 -4104
NCBP1 243 1664
NCBP2 1850 2484
PABPC1 3634 2755
PNRC2 6304 539
PPP2CA -257 -6606
PPP2R1A -3263 -6442
PPP2R2A 5688 4891
RBM8A 5531 -7145
RNPS1 -2412 -7853
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SMG1 -1587 6695
SMG5 -7249 -2986
SMG6 -5033 -1147
SMG7 -3734 5142
SMG8 3756 -3331
SMG9 -7761 -3627
UBA52 5424 -6595
UPF1 -3243 -3730
UPF2 4145 4765
UPF3A -2314 7568
UPF3B -2719 6252



Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
metric value
setSize 113
pMANOVA 6.45e-39
p.adjustMANOVA 4.99e-37
s.dist 0.724
s.OAvRCA 0.561
s.OAvRCR -0.458
p.OAvRCA 6.39e-25
p.OAvRCR 4.17e-17




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RBM8A 5531 -7145
RPL4 7315 -5260

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CASC3 4184 -1259
DCP1A 2863 -1944
EIF4A3 360 -7269
EIF4G1 -5022 -6698
ETF1 1413 -2712
FAU 7475 -5933
GSPT1 -2979 -7496
GSPT2 -1852 -212
MAGOH 5002 -607
MAGOHB 2421 -4104
NCBP1 243 1664
NCBP2 1850 2484
PABPC1 3634 2755
PNRC2 6304 539
PPP2CA -257 -6606
PPP2R1A -3263 -6442
PPP2R2A 5688 4891
RBM8A 5531 -7145
RNPS1 -2412 -7853
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SMG1 -1587 6695
SMG5 -7249 -2986
SMG6 -5033 -1147
SMG7 -3734 5142
SMG8 3756 -3331
SMG9 -7761 -3627
UBA52 5424 -6595
UPF1 -3243 -3730
UPF2 4145 4765
UPF3A -2314 7568
UPF3B -2719 6252



Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
metric value
setSize 21
pMANOVA 9.15e-08
p.adjustMANOVA 1.08e-06
s.dist 0.715
s.OAvRCA 0.677
s.OAvRCR 0.231
p.OAvRCA 7.8e-08
p.OAvRCR 0.0663




Top 20 genes
Gene OAvRCA OAvRCR
OR14J1 7215 5810
OR2M3 7835 5100
OR5AS1 7056 4993
OR10H5 7926 4088
OR6C75 8077 3089
REEP1 4661 4653
OR5A1 7814 2146
OR8A1 2756 4798
OR6Y1 7878 1410
OR1D2 7515 711
OR5AN1 7271 699
OR4D9 6734 537
OR2AT4 7732 287

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
EBF1 -1194 7546
LDB1 -2315 -6967
OR10G3 5395 -888
OR10H5 7926 4088
OR14J1 7215 5810
OR1D2 7515 711
OR1I1 7127 -1220
OR2A7 -131 4297
OR2AT4 7732 287
OR2M3 7835 5100
OR4D9 6734 537
OR52K1 4674 -1871
OR5A1 7814 2146
OR5A2 3668 -2375
OR5AN1 7271 699
OR5AS1 7056 4993
OR6C75 8077 3089
OR6Y1 7878 1410
OR7C1 7703 -73
OR8A1 2756 4798
REEP1 4661 4653



Prefoldin mediated transfer of substrate to CCT/TriC

Prefoldin mediated transfer of substrate to CCT/TriC
metric value
setSize 25
pMANOVA 1.07e-08
p.adjustMANOVA 1.63e-07
s.dist 0.703
s.OAvRCA 0.375
s.OAvRCR -0.594
p.OAvRCA 0.00117
p.OAvRCR 2.7e-07




Top 20 genes
Gene OAvRCA OAvRCR
TUBB2A 7605 -7113
TCP1 6857 -6547
CCT4 6458 -6626
PFDN5 7504 -4630
CCT7 4805 -7085
TUBB1 4041 -8376
TUBB2B 4387 -6813
CCT6A 7166 -4053
TUBB4B 4250 -5896
TUBA4A 2658 -8301
PFDN6 5396 -4011
CCT6B 4659 -2851
TUBA1A 5134 -2541
PFDN2 1483 -8136
CCT2 1628 -5653
TUBB6 2084 -4116
TUBA1C 752 -5469

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ACTB -4936 -3221
CCT2 1628 -5653
CCT3 -142 -7727
CCT4 6458 -6626
CCT5 -917 -3159
CCT6A 7166 -4053
CCT6B 4659 -2851
CCT7 4805 -7085
CCT8 -1621 -4654
PFDN1 -695 -6475
PFDN2 1483 -8136
PFDN4 6190 3305
PFDN5 7504 -4630
PFDN6 5396 -4011
TCP1 6857 -6547
TUBA1A 5134 -2541
TUBA1C 752 -5469
TUBA4A 2658 -8301
TUBB1 4041 -8376
TUBB2A 7605 -7113
TUBB2B 4387 -6813
TUBB3 -4423 -6596
TUBB4B 4250 -5896
TUBB6 2084 -4116
VBP1 4725 75



Scavenging of heme from plasma

Scavenging of heme from plasma
metric value
setSize 13
pMANOVA 1e-04
p.adjustMANOVA 0.000579
s.dist 0.684
s.OAvRCA -0.517
s.OAvRCR -0.448
p.OAvRCA 0.00124
p.OAvRCR 0.0052




Top 20 genes
Gene OAvRCA OAvRCR
IGLC1 -8252 -7392
HP -6199 -8348
JCHAIN -6823 -6372
IGLC3 -8143 -4362
IGLC2 -7616 -4026
APOL1 -7567 -2958
IGHA1 -1286 -3497
IGKC -1103 -3954

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
APOL1 -7567 -2958
CD163 -5034 2451
HBA1 1882 -8429
HBB 34 -8430
HP -6199 -8348
HPX -1323 2756
IGHA1 -1286 -3497
IGKC -1103 -3954
IGLC1 -8252 -7392
IGLC2 -7616 -4026
IGLC3 -8143 -4362
JCHAIN -6823 -6372
LRP1 -5397 2385



Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
metric value
setSize 28
pMANOVA 3.46e-09
p.adjustMANOVA 6.12e-08
s.dist 0.684
s.OAvRCA 0.355
s.OAvRCR -0.585
p.OAvRCA 0.00116
p.OAvRCR 8.39e-08




Top 20 genes
Gene OAvRCA OAvRCR
TUBB2A 7605 -7113
TCP1 6857 -6547
CCT4 6458 -6626
PFDN5 7504 -4630
CCT7 4805 -7085
TUBB1 4041 -8376
TUBB2B 4387 -6813
CCT6A 7166 -4053
TUBB4B 4250 -5896
TUBA4A 2658 -8301
PFDN6 5396 -4011
CCT6B 4659 -2851
TUBA1A 5134 -2541
PFDN2 1483 -8136
TUBAL3 7849 -1465
CCT2 1628 -5653
TUBB6 2084 -4116
TUBA1B 1452 -3970
TUBA1C 752 -5469

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ACTB -4936 -3221
CCT2 1628 -5653
CCT3 -142 -7727
CCT4 6458 -6626
CCT5 -917 -3159
CCT6A 7166 -4053
CCT6B 4659 -2851
CCT7 4805 -7085
CCT8 -1621 -4654
PFDN1 -695 -6475
PFDN2 1483 -8136
PFDN4 6190 3305
PFDN5 7504 -4630
PFDN6 5396 -4011
TCP1 6857 -6547
TUBA1A 5134 -2541
TUBA1B 1452 -3970
TUBA1C 752 -5469
TUBA4A 2658 -8301
TUBA8 -5069 -7618
TUBAL3 7849 -1465
TUBB1 4041 -8376
TUBB2A 7605 -7113
TUBB2B 4387 -6813
TUBB3 -4423 -6596
TUBB4B 4250 -5896
TUBB6 2084 -4116
VBP1 4725 75



Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
metric value
setSize 10
pMANOVA 0.00112
p.adjustMANOVA 0.00534
s.dist 0.676
s.OAvRCA 0.301
s.OAvRCR -0.605
p.OAvRCA 0.0988
p.OAvRCR 0.00093




Top 20 genes
Gene OAvRCA OAvRCR
TCP1 6857 -6547
CCT4 6458 -6626
CCT7 4805 -7085
CCT6A 7166 -4053
CCT6B 4659 -2851
CCT2 1628 -5653

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ACTB -4936 -3221
CCT2 1628 -5653
CCT3 -142 -7727
CCT4 6458 -6626
CCT5 -917 -3159
CCT6A 7166 -4053
CCT6B 4659 -2851
CCT7 4805 -7085
CCT8 -1621 -4654
TCP1 6857 -6547



Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen
metric value
setSize 10
pMANOVA 0.00114
p.adjustMANOVA 0.00542
s.dist 0.675
s.OAvRCA 0.374
s.OAvRCR -0.562
p.OAvRCA 0.0404
p.OAvRCR 0.0021




Top 20 genes
Gene OAvRCA OAvRCR
CA1 8125 -8336
SLC4A1 7150 -8424
CA2 6393 -8320
CYB5R2 6581 -6456
HBA1 1882 -8429
AQP1 5605 -2306
HBB 34 -8430

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
AQP1 5605 -2306
CA1 8125 -8336
CA2 6393 -8320
CYB5R1 -5052 -7939
CYB5R2 6581 -6456
CYB5R4 2008 5066
CYB5RL -2756 5548
HBA1 1882 -8429
HBB 34 -8430
SLC4A1 7150 -8424



O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes
metric value
setSize 10
pMANOVA 0.00114
p.adjustMANOVA 0.00542
s.dist 0.675
s.OAvRCA 0.374
s.OAvRCR -0.562
p.OAvRCA 0.0404
p.OAvRCR 0.0021




Top 20 genes
Gene OAvRCA OAvRCR
CA1 8125 -8336
SLC4A1 7150 -8424
CA2 6393 -8320
CYB5R2 6581 -6456
HBA1 1882 -8429
AQP1 5605 -2306
HBB 34 -8430

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
AQP1 5605 -2306
CA1 8125 -8336
CA2 6393 -8320
CYB5R1 -5052 -7939
CYB5R2 6581 -6456
CYB5R4 2008 5066
CYB5RL -2756 5548
HBA1 1882 -8429
HBB 34 -8430
SLC4A1 7150 -8424



Creation of C4 and C2 activators

Creation of C4 and C2 activators
metric value
setSize 16
pMANOVA 3.29e-05
p.adjustMANOVA 0.000205
s.dist 0.654
s.OAvRCA -0.624
s.OAvRCR -0.197
p.OAvRCA 1.54e-05
p.OAvRCR 0.173




Top 20 genes
Gene OAvRCA OAvRCR
IGLC1 -8252 -7392
IGLC3 -8143 -4362
IGLC2 -7616 -4026
IGHG2 -6735 -4489
IGHG4 -8356 -3505
IGHG3 -4780 -4954
IGHG1 -6652 -3227
C1S -3445 -4145
C1R -5584 -2104
IGKC -1103 -3954
MASP1 -2716 -1601

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
C1QA -5527 5448
C1QB -5423 3690
C1QC -6248 6047
C1R -5584 -2104
C1S -3445 -4145
FCN1 2219 -8094
IGHG1 -6652 -3227
IGHG2 -6735 -4489
IGHG3 -4780 -4954
IGHG4 -8356 -3505
IGKC -1103 -3954
IGLC1 -8252 -7392
IGLC2 -7616 -4026
IGLC3 -8143 -4362
MASP1 -2716 -1601
MASP2 -5667 8107



Transport of connexons to the plasma membrane

Transport of connexons to the plasma membrane
metric value
setSize 14
pMANOVA 0.000149
p.adjustMANOVA 0.000838
s.dist 0.649
s.OAvRCA 0.168
s.OAvRCR -0.627
p.OAvRCA 0.276
p.OAvRCR 4.82e-05




Top 20 genes
Gene OAvRCA OAvRCR
TUBB2A 7605 -7113
TUBB1 4041 -8376
TUBB2B 4387 -6813
TUBB4B 4250 -5896
TUBA4A 2658 -8301
TUBA1A 5134 -2541
TUBAL3 7849 -1465
TUBB6 2084 -4116
TUBA1B 1452 -3970
TUBA1C 752 -5469

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
GJA1 -4867 -7860
GJB2 -7749 1322
TUBA1A 5134 -2541
TUBA1B 1452 -3970
TUBA1C 752 -5469
TUBA4A 2658 -8301
TUBA8 -5069 -7618
TUBAL3 7849 -1465
TUBB1 4041 -8376
TUBB2A 7605 -7113
TUBB2B 4387 -6813
TUBB3 -4423 -6596
TUBB4B 4250 -5896
TUBB6 2084 -4116



Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
metric value
setSize 11
pMANOVA 0.00118
p.adjustMANOVA 0.00557
s.dist 0.637
s.OAvRCA -0.518
s.OAvRCR -0.37
p.OAvRCA 0.00292
p.OAvRCR 0.0336




Top 20 genes
Gene OAvRCA OAvRCR
CD247 -6601 -7827
TRAC -6094 -7020
CD3E -3530 -7836
PTPRC -6782 -2643
LCK -2172 -8152
TRBC1 -1356 -7257
PTPRJ -3736 -173

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CD247 -6601 -7827
CD3E -3530 -7836
CD4 -6427 682
CSK -6605 1173
LCK -2172 -8152
PAG1 -3075 500
PTPN22 -1781 3150
PTPRC -6782 -2643
PTPRJ -3736 -173
TRAC -6094 -7020
TRBC1 -1356 -7257



Downregulation of ERBB2:ERBB3 signaling

Downregulation of ERBB2:ERBB3 signaling
metric value
setSize 13
pMANOVA 0.000559
p.adjustMANOVA 0.00285
s.dist 0.623
s.OAvRCA 0.386
s.OAvRCR -0.488
p.OAvRCA 0.0159
p.OAvRCR 0.00229




Top 20 genes
Gene OAvRCA OAvRCR
NRG2 6205 -7175
UBA52 5424 -6595
RNF41 3823 -7914
UBC 2821 -7580
RPS27A 7259 -2684
NRG1 8151 -2382
AKT3 7685 -2057
ERBB3 7348 -1443

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
AKT1 -7830 -7933
AKT2 -6329 -2372
AKT3 7685 -2057
ERBB2 -74 -3244
ERBB3 7348 -1443
NRG1 8151 -2382
NRG2 6205 -7175
RNF41 3823 -7914
RPS27A 7259 -2684
UBA52 5424 -6595
UBB -266 -7622
UBC 2821 -7580
USP8 6010 4440



IRE1alpha activates chaperones

IRE1alpha activates chaperones
metric value
setSize 49
pMANOVA 4.7e-13
p.adjustMANOVA 1.28e-11
s.dist 0.619
s.OAvRCA -0.389
s.OAvRCR -0.482
p.OAvRCA 2.51e-06
p.OAvRCR 5.31e-09




Top 20 genes
Gene OAvRCA OAvRCR
SHC1 -8031 -7507
ATP6V0D1 -7979 -5948
ZBTB17 -5483 -7439
PREB -7973 -4755
SRPRA -4251 -7740
CUL7 -7169 -4527
MYDGF -3681 -8385
PDIA6 -5368 -5586
EDEM1 -5700 -5205
DNAJB11 -4555 -6336
WIPI1 -3425 -8058
HYOU1 -5358 -4985
KDELR3 -3400 -7715
SSR1 -4054 -6100
SRPRB -3247 -7036
PPP2R5B -7219 -3073
YIF1A -2728 -7617
ERN1 -3235 -6396
SERP1 -3042 -6753
EXTL2 -4484 -3987

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ACADVL -7763 2760
ADD1 4014 1892
ARFGAP1 -8117 -1929
ATP6V0D1 -7979 -5948
CTDSP2 -2375 -1804
CUL7 -7169 -4527
CXXC1 -2863 2687
DCTN1 2749 -1659
DDX11 -6185 -142
DNAJB11 -4555 -6336
DNAJB9 -1896 -6161
DNAJC3 -4255 -3134
EDEM1 -5700 -5205
ERN1 -3235 -6396
EXTL2 -4484 -3987
EXTL3 -56 -7557
FKBP14 -2011 -5822
GFPT1 2960 -7476
GOSR2 2711 -3085
GSK3A -1508 -7398
HDGF -2293 -7722
HSPA5 -1150 -5538
HYOU1 -5358 -4985
KDELR3 -3400 -7715
KLHDC3 -2928 -844
LMNA 318 -6545
MYDGF -3681 -8385
PDIA5 -2332 -6593
PDIA6 -5368 -5586
PLA2G4B -8196 6950
PPP2R5B -7219 -3073
PREB -7973 -4755
SEC31A -1221 -5031
SERP1 -3042 -6753
SHC1 -8031 -7507
SRPRA -4251 -7740
SRPRB -3247 -7036
SSR1 -4054 -6100
SULT1A3 -6020 7152
SYVN1 -6027 58
TATDN2 5125 -7879
TLN1 -5701 -1577
TPP1 -8082 6323
TSPYL2 -1915 -5484
WFS1 1444 -4210
WIPI1 -3425 -8058
XBP1 2212 -7676
YIF1A -2728 -7617
ZBTB17 -5483 -7439



PD-1 signaling

PD-1 signaling
metric value
setSize 11
pMANOVA 0.00177
p.adjustMANOVA 0.00786
s.dist 0.617
s.OAvRCA -0.465
s.OAvRCR -0.406
p.OAvRCA 0.00756
p.OAvRCR 0.0198




Top 20 genes
Gene OAvRCA OAvRCR
CD247 -6601 -7827
TRAC -6094 -7020
CD3E -3530 -7836
CD274 -3684 -4925
LCK -2172 -8152
TRBC1 -1356 -7257
PDCD1LG2 -7350 -1082

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CD247 -6601 -7827
CD274 -3684 -4925
CD3E -3530 -7836
CD4 -6427 682
CSK -6605 1173
LCK -2172 -8152
PDCD1LG2 -7350 -1082
PTPN11 5145 734
PTPN6 -4662 2865
TRAC -6094 -7020
TRBC1 -1356 -7257



XBP1(S) activates chaperone genes

XBP1(S) activates chaperone genes
metric value
setSize 47
pMANOVA 2.08e-12
p.adjustMANOVA 5.17e-11
s.dist 0.615
s.OAvRCA -0.394
s.OAvRCR -0.472
p.OAvRCA 2.9e-06
p.OAvRCR 2.1e-08




Top 20 genes
Gene OAvRCA OAvRCR
SHC1 -8031 -7507
ATP6V0D1 -7979 -5948
ZBTB17 -5483 -7439
PREB -7973 -4755
SRPRA -4251 -7740
CUL7 -7169 -4527
MYDGF -3681 -8385
PDIA6 -5368 -5586
EDEM1 -5700 -5205
DNAJB11 -4555 -6336
WIPI1 -3425 -8058
HYOU1 -5358 -4985
KDELR3 -3400 -7715
SSR1 -4054 -6100
SRPRB -3247 -7036
PPP2R5B -7219 -3073
YIF1A -2728 -7617
SERP1 -3042 -6753
EXTL2 -4484 -3987
HDGF -2293 -7722

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ACADVL -7763 2760
ADD1 4014 1892
ARFGAP1 -8117 -1929
ATP6V0D1 -7979 -5948
CTDSP2 -2375 -1804
CUL7 -7169 -4527
CXXC1 -2863 2687
DCTN1 2749 -1659
DDX11 -6185 -142
DNAJB11 -4555 -6336
DNAJB9 -1896 -6161
DNAJC3 -4255 -3134
EDEM1 -5700 -5205
EXTL2 -4484 -3987
EXTL3 -56 -7557
FKBP14 -2011 -5822
GFPT1 2960 -7476
GOSR2 2711 -3085
GSK3A -1508 -7398
HDGF -2293 -7722
HYOU1 -5358 -4985
KDELR3 -3400 -7715
KLHDC3 -2928 -844
LMNA 318 -6545
MYDGF -3681 -8385
PDIA5 -2332 -6593
PDIA6 -5368 -5586
PLA2G4B -8196 6950
PPP2R5B -7219 -3073
PREB -7973 -4755
SEC31A -1221 -5031
SERP1 -3042 -6753
SHC1 -8031 -7507
SRPRA -4251 -7740
SRPRB -3247 -7036
SSR1 -4054 -6100
SULT1A3 -6020 7152
SYVN1 -6027 58
TATDN2 5125 -7879
TLN1 -5701 -1577
TPP1 -8082 6323
TSPYL2 -1915 -5484
WFS1 1444 -4210
WIPI1 -3425 -8058
XBP1 2212 -7676
YIF1A -2728 -7617
ZBTB17 -5483 -7439



Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
metric value
setSize 10
pMANOVA 0.00363
p.adjustMANOVA 0.0146
s.dist 0.61
s.OAvRCA -0.359
s.OAvRCR -0.492
p.OAvRCA 0.0491
p.OAvRCR 0.00702




Top 20 genes
Gene OAvRCA OAvRCR
PFKFB4 -7838 -7346
PRKACA -6269 -6995
PFKFB3 -5054 -7600
PPP2R1A -3263 -6442
PPP2R5D -2980 -3519
PPP2R1B -767 -5897
PPP2CA -257 -6606

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
PFKFB2 -5962 1519
PFKFB3 -5054 -7600
PFKFB4 -7838 -7346
PPP2CA -257 -6606
PPP2CB 6547 -3848
PPP2R1A -3263 -6442
PPP2R1B -767 -5897
PPP2R5D -2980 -3519
PRKACA -6269 -6995
PRKACB -4819 4437



Olfactory Signaling Pathway

Olfactory Signaling Pathway
metric value
setSize 25
pMANOVA 1.04e-06
p.adjustMANOVA 9.52e-06
s.dist 0.605
s.OAvRCA 0.582
s.OAvRCR 0.164
p.OAvRCA 4.65e-07
p.OAvRCR 0.155




Top 20 genes
Gene OAvRCA OAvRCR
OR14J1 7215 5810
OR2M3 7835 5100
OR5AS1 7056 4993
OR10H5 7926 4088
ANO2 6626 4247
OR6C75 8077 3089
REEP1 4661 4653
OR5A1 7814 2146
GNAL 4865 2747
OR8A1 2756 4798
OR6Y1 7878 1410
OR1D2 7515 711
OR5AN1 7271 699
OR4D9 6734 537
OR2AT4 7732 287

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ADCY3 -6350 -6619
ANO2 6626 4247
EBF1 -1194 7546
GNAL 4865 2747
GNB1 -2746 -7249
LDB1 -2315 -6967
OR10G3 5395 -888
OR10H5 7926 4088
OR14J1 7215 5810
OR1D2 7515 711
OR1I1 7127 -1220
OR2A7 -131 4297
OR2AT4 7732 287
OR2M3 7835 5100
OR4D9 6734 537
OR52K1 4674 -1871
OR5A1 7814 2146
OR5A2 3668 -2375
OR5AN1 7271 699
OR5AS1 7056 4993
OR6C75 8077 3089
OR6Y1 7878 1410
OR7C1 7703 -73
OR8A1 2756 4798
REEP1 4661 4653



FGFR2 ligand binding and activation

FGFR2 ligand binding and activation
metric value
setSize 10
pMANOVA 0.00442
p.adjustMANOVA 0.0173
s.dist 0.604
s.OAvRCA 0.354
s.OAvRCR -0.489
p.OAvRCA 0.0524
p.OAvRCR 0.00741




Top 20 genes
Gene OAvRCA OAvRCR
FGF9 5791 -7157
FGF23 6584 -6138
FGF2 8060 -4490
FGF7 4241 -5850
FGF18 1784 -6597
FGFBP2 5795 -1080
FGF1 270 -8388
FGFR2 79 -7928

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
FGF1 270 -8388
FGF10 -8039 4823
FGF18 1784 -6597
FGF2 8060 -4490
FGF23 6584 -6138
FGF7 4241 -5850
FGF9 5791 -7157
FGFBP2 5795 -1080
FGFBP3 3758 780
FGFR2 79 -7928



Initial triggering of complement

Initial triggering of complement
metric value
setSize 23
pMANOVA 3.97e-06
p.adjustMANOVA 3.19e-05
s.dist 0.599
s.OAvRCA -0.582
s.OAvRCR -0.144
p.OAvRCA 1.36e-06
p.OAvRCR 0.232




Top 20 genes
Gene OAvRCA OAvRCR
IGLC1 -8252 -7392
IGLC3 -8143 -4362
IGLC2 -7616 -4026
IGHG2 -6735 -4489
IGHG4 -8356 -3505
IGHG3 -4780 -4954
IGHG1 -6652 -3227
CFB -5429 -3374
C1S -3445 -4145
C1R -5584 -2104
C4B -6798 -1612
C3 -1738 -5572
C4A -2603 -2271
IGKC -1103 -3954
MASP1 -2716 -1601

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
C1QA -5527 5448
C1QB -5423 3690
C1QC -6248 6047
C1R -5584 -2104
C1S -3445 -4145
C2 -5177 2139
C3 -1738 -5572
C4A -2603 -2271
C4B -6798 -1612
CFB -5429 -3374
CFD -4183 6034
CFP -2769 2183
FCN1 2219 -8094
IGHG1 -6652 -3227
IGHG2 -6735 -4489
IGHG3 -4780 -4954
IGHG4 -8356 -3505
IGKC -1103 -3954
IGLC1 -8252 -7392
IGLC2 -7616 -4026
IGLC3 -8143 -4362
MASP1 -2716 -1601
MASP2 -5667 8107



Transferrin endocytosis and recycling

Transferrin endocytosis and recycling
metric value
setSize 28
pMANOVA 2.54e-07
p.adjustMANOVA 2.69e-06
s.dist 0.599
s.OAvRCA -0.377
s.OAvRCR -0.465
p.OAvRCA 0.000547
p.OAvRCR 2.05e-05




Top 20 genes
Gene OAvRCA OAvRCR
STEAP3 -8265 -6573
ATP6V1B2 -7143 -7032
ATP6V0D1 -7979 -5948
ATP6V0B -7434 -6280
ATP6V0E1 -6302 -7004
ATP6AP1 -7188 -5378
ATP6V1A -6378 -5955
TCIRG1 -8209 -4597
ATP6V1H -3914 -7499
ATP6V1G1 -3913 -7123
ATP6V1F -3823 -5889
ATP6V0C -3083 -6964
ATP6V1E1 -2782 -6760
ATP6V1C1 -3973 -4185
ATP6V1D -1510 -6635
ATP6V1B1 -2428 -1675
TFR2 -465 -7716
STEAP2 -958 -3580

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ATP6AP1 -7188 -5378
ATP6V0A1 -8105 5361
ATP6V0A2 2885 -1667
ATP6V0B -7434 -6280
ATP6V0C -3083 -6964
ATP6V0D1 -7979 -5948
ATP6V0D2 6522 -7867
ATP6V0E1 -6302 -7004
ATP6V0E2 -7048 541
ATP6V1A -6378 -5955
ATP6V1B1 -2428 -1675
ATP6V1B2 -7143 -7032
ATP6V1C1 -3973 -4185
ATP6V1C2 1877 -919
ATP6V1D -1510 -6635
ATP6V1E1 -2782 -6760
ATP6V1E2 2479 -2458
ATP6V1F -3823 -5889
ATP6V1G1 -3913 -7123
ATP6V1H -3914 -7499
HFE -4055 5402
MCOLN1 -7783 7790
STEAP2 -958 -3580
STEAP3 -8265 -6573
TCIRG1 -8209 -4597
TF 7313 -3031
TFR2 -465 -7716
TFRC 1733 -8366



Josephin domain DUBs

Josephin domain DUBs
metric value
setSize 10
pMANOVA 0.00481
p.adjustMANOVA 0.0186
s.dist 0.598
s.OAvRCA 0.177
s.OAvRCR -0.571
p.OAvRCA 0.334
p.OAvRCR 0.00175




Top 20 genes
Gene OAvRCA OAvRCR
UBA52 5424 -6595
JOSD1 4977 -6975
UBC 2821 -7580
RPS27A 7259 -2684
RAD23B 2274 -5775
RAD23A 1181 -6960

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ATXN3 -404 8088
JOSD1 4977 -6975
JOSD2 -4998 -4889
RAD23A 1181 -6960
RAD23B 2274 -5775
RPS27A 7259 -2684
UBA52 5424 -6595
UBB -266 -7622
UBC 2821 -7580
VCP -4633 -7844



TP53 Regulates Transcription of Death Receptors and Ligands

TP53 Regulates Transcription of Death Receptors and Ligands
metric value
setSize 10
pMANOVA 0.00488
p.adjustMANOVA 0.0187
s.dist 0.597
s.OAvRCA 0.193
s.OAvRCR -0.565
p.OAvRCA 0.291
p.OAvRCR 0.00196




Top 20 genes
Gene OAvRCA OAvRCR
FAS 6757 -3538
TNFRSF10D 2528 -8114
TNFRSF10C 1905 -8403
TNFRSF10A 6566 -2173
TMEM219 1654 -1234

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
FAS 6757 -3538
IGFBP3 -2869 -6883
PPP1R13B 5933 2270
TMEM219 1654 -1234
TNFRSF10A 6566 -2173
TNFRSF10B -4786 -6799
TNFRSF10C 1905 -8403
TNFRSF10D 2528 -8114
TP53 -1366 -6481
TP53BP2 -1331 -6982



Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
metric value
setSize 162
pMANOVA 1.79e-37
p.adjustMANOVA 1.31e-35
s.dist 0.594
s.OAvRCA 0.408
s.OAvRCR -0.432
p.OAvRCA 3.26e-19
p.OAvRCR 2.32e-21




Top 20 genes
Gene OAvRCA OAvRCR
RPS19 6330 -7711
RPL39 7154 -6684
RPL3 5894 -7684
ELOC 7186 -6234
RPS3 6521 -6817
RPL41 6840 -6494
FAU 7475 -5933
RPL18A 7558 -5812
RPL10 6684 -6549
RPL18 6456 -6764
RPS29 5992 -7207
RPS5 7237 -5913
RPL19 6578 -6462
RPSA 6976 -6059
RPL36 6083 -6925
RPL8 6643 -6268
RPL37 6536 -6350
RPL17 7148 -5779
RPS8 6878 -5930
RBM8A 5531 -7145

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
CASC3 4184 -1259
COL4A5 5022 4786
CUL2 -289 4154
DAG1 -361 -555
EIF4A3 360 -7269
EIF4G1 -5022 -6698
ELOB 3884 -6616
ELOC 7186 -6234
ETF1 1413 -2712
FAU 7475 -5933
GSPT1 -2979 -7496
GSPT2 -1852 -212
HOXA2 875 6764
LDB1 -2315 -6967
LHX4 6008 7696
MAGOH 5002 -607
MAGOHB 2421 -4104
NCBP1 243 1664
NCBP2 1850 2484
PABPC1 3634 2755
PSMA1 -841 -2609
PSMA2 4128 -2955
PSMA3 -3633 2857
PSMA4 -1999 -3489
PSMA5 -888 -6908
PSMA6 -3807 595
PSMA7 3380 -5394
PSMB1 4446 -1192
PSMB10 -5831 -1520
PSMB2 -1600 -3623
PSMB3 -609 -5832
PSMB4 5006 -7035
PSMB5 2709 -7963
PSMB6 635 -6915
PSMB7 4939 -7115
PSMB8 -984 -1548
PSMB9 -5227 -4096
PSMC1 4231 -3406
PSMC2 -2697 263
PSMC3 5899 -5687
PSMC4 -1712 -6356
PSMC5 3663 -4338
PSMC6 3961 6058
PSMD1 -2837 -5561
PSMD10 4393 -2425
PSMD11 -6170 -5047
PSMD12 3783 -1658
PSMD13 -878 -6891
PSMD14 -460 -6159
PSMD2 -4293 -5811
PSMD3 -5603 -7478
PSMD4 775 -6420
PSMD5 2158 -2544
PSMD6 -2360 662
PSMD7 2055 -3782
PSMD8 -314 -7919
PSMD9 271 -7384
PSME1 -1850 -4205
PSME2 -7014 -4225
PSME3 -4443 -5777
PSME4 -154 -1788
PSMF1 1692 -5639
RBM8A 5531 -7145
RBX1 -2426 -2907
RNPS1 -2412 -7853
ROBO1 -1966 -2959
ROBO2 5647 5506
ROBO3 -2770 4393
RPL10 6684 -6549
RPL10A 5458 -6063
RPL11 6066 -5226
RPL12 5724 -5610
RPL13 5697 -5736
RPL13A 6443 -4779
RPL14 6686 -2781
RPL15 7461 -4081
RPL17 7148 -5779
RPL18 6456 -6764
RPL18A 7558 -5812
RPL19 6578 -6462
RPL21 6729 -2554
RPL22 6905 -2912
RPL22L1 -1986 -3216
RPL23 6497 -5665
RPL23A 6035 -2406
RPL24 5915 -2778
RPL26 6888 -3360
RPL26L1 3335 -5275
RPL27 5843 -4322
RPL27A 5212 -6627
RPL28 2389 -7341
RPL29 7006 -5302
RPL3 5894 -7684
RPL30 7124 -3367
RPL31 6923 -3602
RPL32 6783 -4540
RPL34 7510 -3629
RPL35 5558 -4470
RPL35A 6922 -3272
RPL36 6083 -6925
RPL36A 5159 -1430
RPL36AL 5173 -3943
RPL37 6536 -6350
RPL37A 6353 -6053
RPL38 5383 -5489
RPL39 7154 -6684
RPL39L 3340 -5099
RPL4 7315 -5260
RPL41 6840 -6494
RPL5 7321 -5004
RPL6 6711 -4133
RPL7 7246 -2347
RPL7A 6869 -4577
RPL8 6643 -6268
RPL9 2013 -2282
RPLP0 4430 -7889
RPLP1 5873 -5908
RPLP2 5993 -4732
RPS10 7071 -4239
RPS11 7451 -5162
RPS12 5792 -5764
RPS13 6981 -4075
RPS14 7706 -1547
RPS15 6491 -5857
RPS15A 7262 -4395
RPS16 5840 -5395
RPS17 6645 -4893
RPS18 5272 -6135
RPS19 6330 -7711
RPS2 4552 -7639
RPS20 6916 -2205
RPS21 5390 -5748
RPS23 6921 -3511
RPS24 6482 -3503
RPS25 6093 -4559
RPS26 -1623 849
RPS27 6180 -6113
RPS27A 7259 -2684
RPS27L 6246 -3844
RPS28 5949 -6045
RPS29 5992 -7207
RPS3 6521 -6817
RPS3A 7437 -2255
RPS4X 5021 -5188
RPS4Y1 1708 -434
RPS5 7237 -5913
RPS6 7144 -5016
RPS7 7465 -3124
RPS8 6878 -5930
RPS9 5467 -5154
RPSA 6976 -6059
SEM1 4712 -4493
SLIT1 3134 5616
SLIT2 -5534 -852
UBA52 5424 -6595
UBB -266 -7622
UBC 2821 -7580
UPF2 4145 4765
UPF3A -2314 7568
UPF3B -2719 6252
USP33 -5213 4220
ZSWIM8 -7760 3229



Insulin receptor recycling

Insulin receptor recycling
metric value
setSize 26
pMANOVA 9.61e-07
p.adjustMANOVA 9.01e-06
s.dist 0.594
s.OAvRCA -0.373
s.OAvRCR -0.462
p.OAvRCA 0.00101
p.OAvRCR 4.51e-05




Top 20 genes
Gene OAvRCA OAvRCR
ATP6V1B2 -7143 -7032
ATP6V0D1 -7979 -5948
ATP6V0B -7434 -6280
ATP6V0E1 -6302 -7004
ATP6AP1 -7188 -5378
ATP6V1A -6378 -5955
TCIRG1 -8209 -4597
PTPN1 -3917 -7516
ATP6V1H -3914 -7499
ATP6V1G1 -3913 -7123
ATP6V1F -3823 -5889
ATP6V0C -3083 -6964
ATP6V1E1 -2782 -6760
CTSD -6483 -2606
ATP6V1C1 -3973 -4185
ATP6V1D -1510 -6635
ATP6V1B1 -2428 -1675

Click HERE to show all gene set members

All member genes
OAvRCA OAvRCR
ATP6AP1 -7188 -5378
ATP6V0A1 -8105 5361
ATP6V0A2 2885 -1667
ATP6V0B -7434 -6280
ATP6V0C -3083 -6964
ATP6V0D1 -7979 -5948
ATP6V0D2 6522 -7867
ATP6V0E1 -6302 -7004
ATP6V0E2 -7048 541
ATP6V1A -6378 -5955
ATP6V1B1 -2428 -1675
ATP6V1B2 -7143 -7032
ATP6V1C1 -3973 -4185
ATP6V1C2 1877 -919
ATP6V1D -1510 -6635
ATP6V1E1 -2782 -6760
ATP6V1E2 2479 -2458
ATP6V1F -3823 -5889
ATP6V1G1 -3913 -7123
ATP6V1H -3914 -7499
CTSD -6483 -2606
IDE -2342 3923
INSR 5975 219
PTPN1 -3917 -7516
PTPRF 1740 -1499
TCIRG1 -8209 -4597



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.2.1          rmarkdown_2.25         
## [19] tzdb_0.4.0              xfun_0.41               zlibbioc_1.48.0        
## [22] cachem_1.0.8            jsonlite_1.8.8          highr_0.10             
## [25] later_1.3.2             DelayedArray_0.28.0     BiocParallel_1.36.0    
## [28] parallel_4.3.2          R6_2.5.1                bslib_0.6.1            
## [31] stringi_1.8.3           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [34] assertthat_0.2.1        Rcpp_1.0.11             knitr_1.45             
## [37] httpuv_1.6.13           Matrix_1.6-4            timechange_0.2.0       
## [40] tidyselect_1.2.0        rstudioapi_0.15.0       abind_1.4-5            
## [43] yaml_2.3.8              codetools_0.2-19        lattice_0.22-5         
## [46] plyr_1.8.9              shiny_1.8.0             withr_2.5.2            
## [49] evaluate_0.23           ggstats_0.5.1           xml2_1.3.6             
## [52] pillar_1.9.0            KernSmooth_2.23-22      generics_0.1.3         
## [55] RCurl_1.98-1.13         hms_1.1.3               munsell_0.5.0          
## [58] scales_1.3.0            xtable_1.8-4            glue_1.6.2             
## [61] tools_4.3.2             data.table_1.14.10      webshot_0.5.5          
## [64] locfit_1.5-9.8          fastmatch_1.1-4         cowplot_1.1.2          
## [67] grid_4.3.2              colorspace_2.1-0        GenomeInfoDbData_1.2.11
## [70] cli_3.6.2               fansi_1.0.6             viridisLite_0.4.2      
## [73] S4Arrays_1.2.0          svglite_2.1.3           gtable_0.3.4           
## [76] sass_0.4.8              digest_0.6.33           SparseArray_1.2.3      
## [79] farver_2.1.1            htmlwidgets_1.6.4       htmltools_0.5.7        
## [82] lifecycle_1.0.4         httr_1.4.7              statmod_1.5.0          
## [85] mime_0.12

END of report