date generated: 2024-02-26

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -1.1769575
7SK 0.3057012
A1BG -0.3509761
A1BG.AS1 -1.0241247
A2M 0.9618886
A2M.AS1 2.2323813

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 17294
duplicated_genes_present 0
num_profile_genes_in_sets 8504
num_profile_genes_not_in_sets 8790

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1129
num_genesets_included 1483

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
SARS-CoV-1 modulates host translation machinery 36 5.31e-15 0.753 2.92e-13
Peptide chain elongation 87 3.14e-32 0.732 1.16e-29
Eukaryotic Translation Elongation 92 3.56e-33 0.723 2.70e-30
Classical antibody-mediated complement activation 13 7.28e-06 -0.718 2.08e-04
Viral mRNA Translation 87 5.89e-31 0.717 1.46e-28
Selenocysteine synthesis 91 1.02e-30 0.698 2.15e-28
Formation of a pool of free 40S subunits 99 3.64e-33 0.697 2.70e-30
Eukaryotic Translation Termination 91 1.00e-28 0.674 1.48e-26
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.44e-28 0.664 1.94e-26
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.87e-32 0.655 1.16e-29
Formation of the ternary complex, and subsequently, the 43S complex 51 1.17e-15 0.648 6.66e-14
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.61e-28 0.644 1.99e-26
GTP hydrolysis and joining of the 60S ribosomal subunit 110 2.01e-31 0.643 5.95e-29
FCGR activation 20 7.34e-07 -0.639 2.59e-05
Creation of C4 and C2 activators 16 1.28e-05 -0.630 3.29e-04
Cap-dependent Translation Initiation 117 1.78e-29 0.603 2.93e-27
Eukaryotic Translation Initiation 117 1.78e-29 0.603 2.93e-27
SARS-CoV-2 modulates host translation machinery 49 3.70e-13 0.600 1.66e-11
Expression and translocation of olfactory receptors 22 1.34e-06 0.595 4.52e-05
Translation initiation complex formation 58 7.83e-15 0.590 4.15e-13
Mucopolysaccharidoses 11 8.14e-04 -0.583 1.37e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.49e-14 0.573 1.27e-12
Ribosomal scanning and start codon recognition 58 4.77e-14 0.572 2.36e-12
Selenoamino acid metabolism 113 1.10e-25 0.570 1.25e-23
Initial triggering of complement 24 1.44e-06 -0.568 4.73e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 3.45e-24 0.552 3.19e-22
Nonsense-Mediated Decay (NMD) 113 3.45e-24 0.552 3.19e-22
SRP-dependent cotranslational protein targeting to membrane 110 5.44e-23 0.545 4.74e-21
Scavenging of heme from plasma 14 6.59e-04 -0.526 1.14e-02
Gluconeogenesis 28 1.69e-06 -0.523 5.33e-05
Olfactory Signaling Pathway 26 5.38e-06 0.515 1.57e-04
Trafficking and processing of endosomal TLR 12 2.05e-03 -0.514 2.44e-02
Role of LAT2/NTAL/LAB on calcium mobilization 20 9.59e-05 -0.504 2.09e-03
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 1.60e-04 -0.500 3.21e-03
SARS-CoV-2 modulates autophagy 11 5.40e-03 -0.484 5.48e-02
Transcriptional regulation of pluripotent stem cells 16 8.97e-04 0.480 1.43e-02
Scavenging by Class A Receptors 16 9.54e-04 -0.477 1.49e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 3.45e-03 -0.468 3.94e-02
ABC transporters in lipid homeostasis 12 5.06e-03 -0.467 5.29e-02
Interleukin-2 signaling 11 8.73e-03 -0.457 7.99e-02
The role of Nef in HIV-1 replication and disease pathogenesis 26 6.19e-05 -0.454 1.43e-03
Influenza Viral RNA Transcription and Replication 134 1.51e-19 0.452 1.12e-17
TRAF3-dependent IRF activation pathway 13 5.40e-03 -0.446 5.48e-02
Packaging Of Telomere Ends 13 6.56e-03 0.435 6.40e-02
Retrograde neurotrophin signalling 14 5.61e-03 -0.427 5.63e-02
Binding and Uptake of Ligands by Scavenger Receptors 39 4.39e-06 -0.425 1.30e-04
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 12 1.09e-02 0.425 9.17e-02
Synthesis of PIPs at the Golgi membrane 15 5.48e-03 -0.414 5.52e-02
Other semaphorin interactions 19 1.87e-03 -0.412 2.29e-02
Role of phospholipids in phagocytosis 32 6.82e-05 -0.407 1.53e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
SARS-CoV-1 modulates host translation machinery 36 5.31e-15 0.753000 2.92e-13
Peptide chain elongation 87 3.14e-32 0.732000 1.16e-29
Eukaryotic Translation Elongation 92 3.56e-33 0.723000 2.70e-30
Classical antibody-mediated complement activation 13 7.28e-06 -0.718000 2.08e-04
Viral mRNA Translation 87 5.89e-31 0.717000 1.46e-28
Selenocysteine synthesis 91 1.02e-30 0.698000 2.15e-28
Formation of a pool of free 40S subunits 99 3.64e-33 0.697000 2.70e-30
Eukaryotic Translation Termination 91 1.00e-28 0.674000 1.48e-26
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.44e-28 0.664000 1.94e-26
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.87e-32 0.655000 1.16e-29
Formation of the ternary complex, and subsequently, the 43S complex 51 1.17e-15 0.648000 6.66e-14
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.61e-28 0.644000 1.99e-26
GTP hydrolysis and joining of the 60S ribosomal subunit 110 2.01e-31 0.643000 5.95e-29
FCGR activation 20 7.34e-07 -0.639000 2.59e-05
Creation of C4 and C2 activators 16 1.28e-05 -0.630000 3.29e-04
Cap-dependent Translation Initiation 117 1.78e-29 0.603000 2.93e-27
Eukaryotic Translation Initiation 117 1.78e-29 0.603000 2.93e-27
SARS-CoV-2 modulates host translation machinery 49 3.70e-13 0.600000 1.66e-11
Expression and translocation of olfactory receptors 22 1.34e-06 0.595000 4.52e-05
Translation initiation complex formation 58 7.83e-15 0.590000 4.15e-13
Mucopolysaccharidoses 11 8.14e-04 -0.583000 1.37e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.49e-14 0.573000 1.27e-12
Ribosomal scanning and start codon recognition 58 4.77e-14 0.572000 2.36e-12
Selenoamino acid metabolism 113 1.10e-25 0.570000 1.25e-23
Initial triggering of complement 24 1.44e-06 -0.568000 4.73e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 3.45e-24 0.552000 3.19e-22
Nonsense-Mediated Decay (NMD) 113 3.45e-24 0.552000 3.19e-22
SRP-dependent cotranslational protein targeting to membrane 110 5.44e-23 0.545000 4.74e-21
Scavenging of heme from plasma 14 6.59e-04 -0.526000 1.14e-02
Gluconeogenesis 28 1.69e-06 -0.523000 5.33e-05
Olfactory Signaling Pathway 26 5.38e-06 0.515000 1.57e-04
Trafficking and processing of endosomal TLR 12 2.05e-03 -0.514000 2.44e-02
Role of LAT2/NTAL/LAB on calcium mobilization 20 9.59e-05 -0.504000 2.09e-03
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 1.60e-04 -0.500000 3.21e-03
SARS-CoV-2 modulates autophagy 11 5.40e-03 -0.484000 5.48e-02
Transcriptional regulation of pluripotent stem cells 16 8.97e-04 0.480000 1.43e-02
Scavenging by Class A Receptors 16 9.54e-04 -0.477000 1.49e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 3.45e-03 -0.468000 3.94e-02
ABC transporters in lipid homeostasis 12 5.06e-03 -0.467000 5.29e-02
Interleukin-2 signaling 11 8.73e-03 -0.457000 7.99e-02
The role of Nef in HIV-1 replication and disease pathogenesis 26 6.19e-05 -0.454000 1.43e-03
Influenza Viral RNA Transcription and Replication 134 1.51e-19 0.452000 1.12e-17
TRAF3-dependent IRF activation pathway 13 5.40e-03 -0.446000 5.48e-02
Packaging Of Telomere Ends 13 6.56e-03 0.435000 6.40e-02
Retrograde neurotrophin signalling 14 5.61e-03 -0.427000 5.63e-02
Binding and Uptake of Ligands by Scavenger Receptors 39 4.39e-06 -0.425000 1.30e-04
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 12 1.09e-02 0.425000 9.17e-02
Synthesis of PIPs at the Golgi membrane 15 5.48e-03 -0.414000 5.52e-02
Other semaphorin interactions 19 1.87e-03 -0.412000 2.29e-02
Role of phospholipids in phagocytosis 32 6.82e-05 -0.407000 1.53e-03
TNFs bind their physiological receptors 21 1.37e-03 -0.404000 1.87e-02
XBP1(S) activates chaperone genes 47 1.82e-06 -0.402000 5.61e-05
Diseases associated with N-glycosylation of proteins 20 1.88e-03 -0.401000 2.29e-02
Regulation of expression of SLITs and ROBOs 162 2.08e-18 0.398000 1.40e-16
Regulation of KIT signaling 16 5.82e-03 -0.398000 5.80e-02
Influenza Infection 153 2.32e-17 0.397000 1.50e-15
IRE1alpha activates chaperones 49 1.54e-06 -0.397000 4.97e-05
Major pathway of rRNA processing in the nucleolus and cytosol 179 8.19e-20 0.395000 6.40e-18
Free fatty acids regulate insulin secretion 10 3.09e-02 -0.394000 2.00e-01
rRNA processing in the nucleus and cytosol 189 4.34e-20 0.387000 3.58e-18
Transferrin endocytosis and recycling 28 4.33e-04 -0.384000 7.92e-03
FOXO-mediated transcription of cell cycle genes 15 1.01e-02 0.384000 8.75e-02
Maturation of nucleoprotein 9683610 11 2.76e-02 -0.384000 1.89e-01
Insulin receptor recycling 26 8.00e-04 -0.380000 1.36e-02
Interleukin receptor SHC signaling 22 2.06e-03 -0.380000 2.44e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 5.30e-03 -0.380000 5.46e-02
Downregulation of ERBB2:ERBB3 signaling 13 1.80e-02 0.379000 1.41e-01
Assembly of the ORC complex at the origin of replication 16 9.10e-03 0.377000 8.13e-02
Plasma lipoprotein assembly 11 3.06e-02 -0.377000 2.00e-01
RHO GTPases activate PKNs 38 6.37e-05 0.375000 1.45e-03
Hyaluronan metabolism 16 9.68e-03 -0.374000 8.45e-02
TRAF6 mediated IRF7 activation 15 1.23e-02 -0.373000 9.99e-02
RNA Polymerase I Promoter Opening 10 4.18e-02 0.372000 2.40e-01
Phosphorylation of CD3 and TCR zeta chains 13 2.10e-02 -0.370000 1.53e-01
Interleukin-2 family signaling 36 1.27e-04 -0.369000 2.61e-03
rRNA processing 199 2.81e-19 0.369000 1.99e-17
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 4.42e-02 -0.368000 2.51e-01
Erythrocytes take up carbon dioxide and release oxygen 10 4.54e-02 0.365000 2.54e-01
O2/CO2 exchange in erythrocytes 10 4.54e-02 0.365000 2.54e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 1.57e-03 0.365000 2.01e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 49 1.00e-05 0.365000 2.75e-04
Formation of annular gap junctions 11 3.78e-02 -0.362000 2.25e-01
Synthesis of PE 12 3.08e-02 -0.360000 2.00e-01
PD-1 signaling 14 1.98e-02 -0.360000 1.49e-01
Lysosome Vesicle Biogenesis 33 3.52e-04 -0.359000 6.60e-03
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 4.97e-02 0.358000 2.62e-01
Regulation of Complement cascade 38 1.73e-04 -0.352000 3.42e-03
Cellular response to starvation 149 1.63e-13 0.350000 7.79e-12
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 4.46e-02 -0.350000 2.51e-01
alpha-linolenic acid (ALA) metabolism 11 4.46e-02 -0.350000 2.51e-01
Glucose metabolism 83 4.33e-08 -0.348000 1.69e-06
CD28 dependent Vav1 pathway 11 4.63e-02 -0.347000 2.57e-01
FGFR2 ligand binding and activation 10 5.82e-02 0.346000 2.92e-01
PI-3K cascade:FGFR4 11 4.71e-02 0.346000 2.57e-01
Formation of tubulin folding intermediates by CCT/TriC 21 6.10e-03 0.346000 6.03e-02
Plasma lipoprotein remodeling 19 9.11e-03 -0.346000 8.13e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 1.58e-03 0.345000 2.01e-02
Complement cascade 43 1.02e-04 -0.342000 2.13e-03
FCGR3A-mediated IL10 synthesis 44 8.51e-05 -0.342000 1.88e-03
Protein methylation 15 2.21e-02 0.341000 1.59e-01
ROS and RNS production in phagocytes 31 1.03e-03 -0.341000 1.55e-02
Striated Muscle Contraction 32 8.88e-04 -0.340000 1.43e-02
cGMP effects 13 3.48e-02 0.338000 2.14e-01
Cellular hexose transport 14 2.87e-02 -0.338000 1.92e-01
WNT5A-dependent internalization of FZD4 14 3.07e-02 -0.334000 2.00e-01
SHC1 events in EGFR signaling 13 3.77e-02 -0.333000 2.25e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 102 6.82e-09 -0.332000 2.81e-07
LDL clearance 17 1.90e-02 -0.329000 1.44e-01
Translocation of ZAP-70 to Immunological synapse 10 7.24e-02 -0.328000 3.35e-01
Defects in cobalamin (B12) metabolism 12 4.92e-02 0.328000 2.61e-01
Cholesterol biosynthesis 26 4.29e-03 0.324000 4.64e-02
Regulation of IFNA/IFNB signaling 12 5.28e-02 -0.323000 2.72e-01
GPVI-mediated activation cascade 32 1.59e-03 -0.323000 2.01e-02
Interleukin-15 signaling 14 3.71e-02 -0.322000 2.25e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 8.19e-03 -0.319000 7.64e-02
Maturation of nucleoprotein 9694631 15 3.32e-02 -0.318000 2.08e-01
Glycosphingolipid metabolism 36 9.88e-04 -0.317000 1.53e-02
Gap junction degradation 12 5.73e-02 -0.317000 2.88e-01
Aggrephagy 34 1.40e-03 0.317000 1.87e-02
Pexophagy 11 7.01e-02 0.315000 3.33e-01
RHO GTPases activate CIT 19 1.89e-02 0.311000 1.44e-01
Other interleukin signaling 21 1.37e-02 -0.311000 1.11e-01
TNFR1-induced proapoptotic signaling 25 7.38e-03 -0.310000 7.10e-02
Cleavage of the damaged purine 16 3.24e-02 0.309000 2.04e-01
Depurination 16 3.24e-02 0.309000 2.04e-01
Recognition and association of DNA glycosylase with site containing an affected purine 16 3.24e-02 0.309000 2.04e-01
Glycolysis 66 1.45e-05 -0.309000 3.63e-04
Maturation of spike protein 9694548 37 1.21e-03 -0.307000 1.75e-02
GAB1 signalosome 16 3.41e-02 -0.306000 2.13e-01
DNA methylation 11 8.03e-02 0.305000 3.54e-01
Caspase activation via extrinsic apoptotic signalling pathway 23 1.22e-02 -0.302000 9.99e-02
Signaling by ROBO receptors 203 1.80e-13 0.300000 8.34e-12
NR1H2 and NR1H3-mediated signaling 39 1.22e-03 -0.299000 1.75e-02
RHO GTPases Activate ROCKs 19 2.41e-02 0.299000 1.71e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 8.76e-02 -0.297000 3.76e-01
LGI-ADAM interactions 10 1.04e-01 -0.297000 4.08e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 3.45e-02 -0.296000 2.14e-01
HSF1 activation 25 1.10e-02 0.294000 9.19e-02
Interleukin-10 signaling 36 2.32e-03 -0.293000 2.73e-02
Folding of actin by CCT/TriC 10 1.10e-01 0.292000 4.22e-01
Assembly of active LPL and LIPC lipase complexes 12 8.18e-02 -0.290000 3.60e-01
E3 ubiquitin ligases ubiquitinate target proteins 44 1.02e-03 0.286000 1.55e-02
DAP12 interactions 35 3.40e-03 -0.286000 3.90e-02
Translation 291 5.21e-17 0.286000 3.09e-15
CD22 mediated BCR regulation 11 1.01e-01 -0.286000 4.04e-01
Attenuation phase 22 2.03e-02 0.286000 1.50e-01
Interferon gamma signaling 74 2.17e-05 -0.286000 5.26e-04
Diseases associated with the TLR signaling cascade 27 1.03e-02 -0.285000 8.83e-02
Diseases of Immune System 27 1.03e-02 -0.285000 8.83e-02
Keratan sulfate degradation 13 7.80e-02 -0.282000 3.49e-01
Aspirin ADME 14 6.76e-02 -0.282000 3.27e-01
Trafficking of GluR2-containing AMPA receptors 15 5.91e-02 -0.282000 2.95e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 5.15e-02 -0.281000 2.68e-01
GRB2 events in EGFR signaling 12 9.25e-02 -0.281000 3.91e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 7.24e-02 -0.277000 3.35e-01
Sema4D induced cell migration and growth-cone collapse 20 3.19e-02 0.277000 2.04e-01
Hyaluronan uptake and degradation 11 1.14e-01 -0.275000 4.30e-01
Collagen degradation 56 3.80e-04 -0.275000 7.04e-03
Signaling by BMP 24 2.10e-02 0.272000 1.53e-01
Late SARS-CoV-2 Infection Events 66 1.55e-04 -0.269000 3.15e-03
Activation of the AP-1 family of transcription factors 10 1.41e-01 0.269000 4.82e-01
Disorders of Developmental Biology 12 1.09e-01 -0.267000 4.19e-01
Disorders of Nervous System Development 12 1.09e-01 -0.267000 4.19e-01
Loss of function of MECP2 in Rett syndrome 12 1.09e-01 -0.267000 4.19e-01
Pervasive developmental disorders 12 1.09e-01 -0.267000 4.19e-01
Costimulation by the CD28 family 56 5.49e-04 -0.267000 9.92e-03
Activation of AMPK downstream of NMDARs 21 3.44e-02 0.267000 2.14e-01
Cytosolic iron-sulfur cluster assembly 13 9.71e-02 -0.266000 4.03e-01
Insulin processing 21 3.63e-02 -0.264000 2.22e-01
PI-3K cascade:FGFR3 12 1.14e-01 0.263000 4.30e-01
Biosynthesis of specialized proresolving mediators (SPMs) 13 1.01e-01 -0.263000 4.04e-01
Inhibition of DNA recombination at telomere 27 1.83e-02 0.262000 1.42e-01
Inflammasomes 21 3.74e-02 -0.262000 2.25e-01
Interferon alpha/beta signaling 57 6.49e-04 -0.261000 1.13e-02
CD28 dependent PI3K/Akt signaling 21 3.94e-02 -0.260000 2.33e-01
Intra-Golgi traffic 41 4.23e-03 -0.258000 4.62e-02
Germ layer formation at gastrulation 10 1.58e-01 0.258000 5.10e-01
Dectin-2 family 14 9.48e-02 -0.258000 3.98e-01
Sema4D in semaphorin signaling 24 2.89e-02 0.258000 1.93e-01
CD28 co-stimulation 32 1.17e-02 -0.257000 9.65e-02
SARS-CoV-1-host interactions 95 1.48e-05 0.257000 3.65e-04
Pregnenolone biosynthesis 10 1.59e-01 -0.257000 5.10e-01
Translation of Structural Proteins 9694635 57 8.48e-04 -0.256000 1.41e-02
RUNX3 regulates p14-ARF 10 1.64e-01 -0.254000 5.18e-01
Cardiogenesis 19 5.58e-02 0.254000 2.81e-01
Cleavage of the damaged pyrimidine 21 4.71e-02 0.250000 2.57e-01
Depyrimidination 21 4.71e-02 0.250000 2.57e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 21 4.71e-02 0.250000 2.57e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 1.44e-03 -0.248000 1.91e-02
HS-GAG degradation 22 4.39e-02 -0.248000 2.51e-01
Glycogen synthesis 13 1.22e-01 0.247000 4.49e-01
Signaling by CSF1 (M-CSF) in myeloid cells 31 1.76e-02 -0.246000 1.38e-01
Processing and activation of SUMO 10 1.78e-01 0.246000 5.39e-01
SUMOylation of immune response proteins 11 1.60e-01 -0.245000 5.10e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 1.29e-01 0.243000 4.59e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 1.06e-01 0.241000 4.14e-01
PI-3K cascade:FGFR2 14 1.19e-01 0.241000 4.41e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 1.86e-02 -0.240000 1.43e-01
Cohesin Loading onto Chromatin 10 1.88e-01 0.240000 5.41e-01
Paracetamol ADME 19 6.98e-02 -0.240000 3.33e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 1.09e-01 0.239000 4.19e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 1.09e-01 0.239000 4.19e-01
RHOBTB1 GTPase cycle 23 4.74e-02 0.239000 2.58e-01
Early Phase of HIV Life Cycle 14 1.25e-01 -0.237000 4.50e-01
Blood group systems biosynthesis 14 1.25e-01 0.237000 4.50e-01
FCERI mediated Ca+2 mobilization 35 1.55e-02 -0.236000 1.24e-01
DCC mediated attractive signaling 13 1.41e-01 0.236000 4.82e-01
Fcgamma receptor (FCGR) dependent phagocytosis 92 9.99e-05 -0.235000 2.13e-03
Signalling to RAS 20 7.05e-02 -0.234000 3.33e-01
VLDLR internalisation and degradation 15 1.18e-01 -0.233000 4.41e-01
Amino acids regulate mTORC1 50 4.35e-03 -0.233000 4.67e-02
EPHA-mediated growth cone collapse 24 4.87e-02 0.232000 2.61e-01
Integrin signaling 24 4.88e-02 -0.232000 2.61e-01
Interleukin-35 Signalling 10 2.06e-01 -0.231000 5.67e-01
DAP12 signaling 27 3.82e-02 -0.230000 2.27e-01
Azathioprine ADME 19 8.25e-02 -0.230000 3.62e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 43 9.21e-03 -0.230000 8.13e-02
PECAM1 interactions 12 1.69e-01 -0.229000 5.24e-01
Nitric oxide stimulates guanylate cyclase 17 1.02e-01 0.229000 4.04e-01
Regulation of actin dynamics for phagocytic cup formation 68 1.12e-03 -0.229000 1.64e-02
Regulation of FZD by ubiquitination 16 1.14e-01 0.228000 4.30e-01
Chaperone Mediated Autophagy 20 7.81e-02 0.228000 3.49e-01
FCGR3A-mediated phagocytosis 66 1.40e-03 -0.227000 1.87e-02
Leishmania phagocytosis 66 1.40e-03 -0.227000 1.87e-02
Parasite infection 66 1.40e-03 -0.227000 1.87e-02
Crosslinking of collagen fibrils 15 1.28e-01 -0.227000 4.55e-01
Signaling by Activin 13 1.58e-01 0.226000 5.10e-01
PI-3K cascade:FGFR1 13 1.59e-01 0.226000 5.10e-01
EPH-ephrin mediated repulsion of cells 46 8.19e-03 -0.225000 7.64e-02
Apoptotic cleavage of cellular proteins 35 2.18e-02 0.224000 1.58e-01
Citric acid cycle (TCA cycle) 22 6.95e-02 -0.224000 3.32e-01
MyD88 deficiency (TLR2/4) 14 1.48e-01 -0.223000 4.90e-01
G-protein beta:gamma signalling 28 4.14e-02 -0.223000 2.39e-01
trans-Golgi Network Vesicle Budding 70 1.30e-03 -0.222000 1.85e-02
Erythropoietin activates RAS 13 1.66e-01 -0.222000 5.19e-01
Generation of second messenger molecules 24 6.00e-02 -0.222000 2.98e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 35 2.32e-02 -0.222000 1.66e-01
Condensation of Prometaphase Chromosomes 11 2.03e-01 -0.222000 5.62e-01
FRS-mediated FGFR4 signaling 13 1.67e-01 0.221000 5.20e-01
Repression of WNT target genes 14 1.52e-01 0.221000 4.96e-01
Polo-like kinase mediated events 14 1.52e-01 -0.221000 4.96e-01
Amino acid transport across the plasma membrane 21 8.01e-02 -0.221000 3.54e-01
Base-Excision Repair, AP Site Formation 23 6.72e-02 0.220000 3.26e-01
Intraflagellar transport 49 8.06e-03 0.219000 7.61e-02
RAS processing 22 7.58e-02 0.219000 3.44e-01
NGF-stimulated transcription 35 2.53e-02 0.218000 1.78e-01
Downregulation of TGF-beta receptor signaling 26 5.46e-02 0.218000 2.78e-01
TRP channels 20 9.29e-02 -0.217000 3.91e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 15 1.46e-01 -0.217000 4.88e-01
Regulation of CDH11 gene transcription 10 2.38e-01 -0.215000 6.05e-01
NOTCH2 intracellular domain regulates transcription 11 2.17e-01 -0.215000 5.81e-01
Translesion Synthesis by POLH 18 1.16e-01 0.214000 4.34e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 2.41e-01 0.214000 6.08e-01
Biosynthesis of DHA-derived SPMs 11 2.19e-01 -0.214000 5.85e-01
RHOBTB2 GTPase cycle 23 7.61e-02 0.214000 3.44e-01
Zinc transporters 10 2.42e-01 -0.213000 6.09e-01
Processing of Intronless Pre-mRNAs 20 9.90e-02 -0.213000 4.04e-01
FCERI mediated MAPK activation 36 2.72e-02 -0.213000 1.88e-01
Collagen biosynthesis and modifying enzymes 61 4.23e-03 -0.212000 4.62e-02
Cell surface interactions at the vascular wall 114 1.02e-04 -0.211000 2.13e-03
Pre-NOTCH Processing in Golgi 18 1.23e-01 -0.210000 4.49e-01
Interaction between L1 and Ankyrins 26 6.44e-02 0.210000 3.14e-01
Anti-inflammatory response favouring Leishmania parasite infection 76 1.60e-03 -0.209000 2.01e-02
Leishmania parasite growth and survival 76 1.60e-03 -0.209000 2.01e-02
Translation of Structural Proteins 9683701 29 5.10e-02 -0.209000 2.67e-01
Apoptotic execution phase 43 1.76e-02 0.209000 1.38e-01
PINK1-PRKN Mediated Mitophagy 21 9.83e-02 0.208000 4.04e-01
SLBP independent Processing of Histone Pre-mRNAs 10 2.54e-01 0.208000 6.19e-01
IRAK1 recruits IKK complex 14 1.77e-01 0.208000 5.39e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 1.77e-01 0.208000 5.39e-01
Regulation of TP53 Activity through Association with Co-factors 11 2.34e-01 -0.207000 6.03e-01
Signaling by FGFR3 in disease 16 1.52e-01 0.207000 4.96e-01
Apoptotic factor-mediated response 20 1.11e-01 -0.206000 4.22e-01
Establishment of Sister Chromatid Cohesion 11 2.38e-01 0.205000 6.05e-01
Mitochondrial translation termination 88 8.97e-04 0.205000 1.43e-02
IRAK4 deficiency (TLR2/4) 15 1.70e-01 -0.205000 5.26e-01
SUMOylation of DNA replication proteins 46 1.69e-02 -0.204000 1.34e-01
Mitochondrial translation initiation 88 1.06e-03 0.202000 1.59e-02
Mitochondrial translation elongation 88 1.09e-03 0.202000 1.61e-02
PLC beta mediated events 45 1.97e-02 -0.201000 1.49e-01
HSF1-dependent transactivation 32 4.93e-02 0.201000 2.61e-01
Interferon Signaling 166 8.45e-06 -0.200000 2.36e-04
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.80e-01 -0.200000 5.41e-01
RHOBTB GTPase Cycle 35 4.11e-02 0.199000 2.38e-01
Assembly of collagen fibrils and other multimeric structures 55 1.05e-02 -0.199000 8.99e-02
Regulation of NPAS4 gene expression 12 2.32e-01 0.199000 6.00e-01
Signaling by Hippo 20 1.24e-01 0.199000 4.49e-01
TNFR1-induced NF-kappa-B signaling pathway 33 4.84e-02 -0.199000 2.61e-01
rRNA modification in the nucleus and cytosol 59 8.50e-03 0.198000 7.83e-02
Inactivation, recovery and regulation of the phototransduction cascade 20 1.26e-01 0.198000 4.50e-01
Nuclear Pore Complex (NPC) Disassembly 36 4.02e-02 -0.198000 2.35e-01
Post-chaperonin tubulin folding pathway 18 1.47e-01 0.197000 4.90e-01
Degradation of cysteine and homocysteine 12 2.36e-01 -0.197000 6.03e-01
P2Y receptors 11 2.57e-01 0.197000 6.22e-01
Ca-dependent events 33 5.03e-02 -0.197000 2.64e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 102 6.04e-04 -0.197000 1.07e-02
The phototransduction cascade 21 1.19e-01 0.196000 4.41e-01
Metabolism of carbohydrates 259 5.77e-08 -0.196000 2.19e-06
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 1.16e-02 -0.195000 9.62e-02
Unfolded Protein Response (UPR) 91 1.36e-03 -0.194000 1.87e-02
Vitamin D (calciferol) metabolism 10 2.87e-01 -0.194000 6.47e-01
Activation of Matrix Metalloproteinases 24 1.01e-01 -0.193000 4.04e-01
Collagen formation 82 2.52e-03 -0.193000 2.94e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 2.92e-01 0.193000 6.49e-01
Regulation of TLR by endogenous ligand 16 1.83e-01 -0.192000 5.41e-01
Heparan sulfate/heparin (HS-GAG) metabolism 45 2.61e-02 -0.192000 1.83e-01
Mitochondrial translation 94 1.33e-03 0.192000 1.87e-02
Selective autophagy 71 5.27e-03 0.192000 5.46e-02
Cell recruitment (pro-inflammatory response) 25 1.02e-01 -0.189000 4.04e-01
Purinergic signaling in leishmaniasis infection 25 1.02e-01 -0.189000 4.04e-01
Regulation of PTEN mRNA translation 11 2.78e-01 0.189000 6.43e-01
COPII-mediated vesicle transport 65 8.42e-03 -0.189000 7.80e-02
Elevation of cytosolic Ca2+ levels 13 2.41e-01 -0.188000 6.08e-01
Biotin transport and metabolism 11 2.81e-01 -0.188000 6.44e-01
Formation of the beta-catenin:TCF transactivating complex 37 4.93e-02 0.187000 2.61e-01
Deposition of new CENPA-containing nucleosomes at the centromere 31 7.26e-02 0.186000 3.35e-01
Nucleosome assembly 31 7.26e-02 0.186000 3.35e-01
Membrane binding and targetting of GAG proteins 14 2.29e-01 0.186000 5.97e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 2.29e-01 0.186000 5.97e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 2.87e-01 -0.185000 6.47e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.88e-01 -0.185000 6.47e-01
Post-translational protein phosphorylation 79 4.50e-03 -0.185000 4.76e-02
Sensory perception of taste 16 2.00e-01 -0.185000 5.59e-01
Telomere C-strand synthesis initiation 13 2.52e-01 0.184000 6.19e-01
Caspase activation via Death Receptors in the presence of ligand 15 2.19e-01 -0.183000 5.85e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 2.93e-01 0.183000 6.49e-01
Translesion synthesis by POLI 17 1.93e-01 0.182000 5.44e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 24 1.22e-01 0.182000 4.49e-01
SUMOylation of ubiquitinylation proteins 39 4.95e-02 -0.182000 2.61e-01
Plasma lipoprotein clearance 32 7.60e-02 -0.181000 3.44e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 2.59e-01 0.181000 6.24e-01
Metal ion SLC transporters 18 1.85e-01 -0.181000 5.41e-01
p38MAPK events 13 2.60e-01 -0.181000 6.24e-01
Degradation of the extracellular matrix 114 8.87e-04 -0.180000 1.43e-02
G1/S-Specific Transcription 27 1.06e-01 -0.180000 4.12e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.81e-01 -0.180000 6.44e-01
PRC2 methylates histones and DNA 20 1.64e-01 0.180000 5.18e-01
MECP2 regulates neuronal receptors and channels 16 2.14e-01 0.179000 5.76e-01
Carboxyterminal post-translational modifications of tubulin 31 8.43e-02 0.179000 3.67e-01
Antigen processing-Cross presentation 92 3.01e-03 -0.179000 3.49e-02
Diseases of carbohydrate metabolism 29 9.70e-02 -0.178000 4.03e-01
Metabolism of steroid hormones 21 1.59e-01 -0.177000 5.10e-01
Smooth Muscle Contraction 38 5.93e-02 0.177000 2.95e-01
SIRT1 negatively regulates rRNA expression 15 2.37e-01 0.176000 6.05e-01
RHO GTPases Activate NADPH Oxidases 21 1.65e-01 -0.175000 5.19e-01
RNA Polymerase I Promoter Escape 38 6.25e-02 0.175000 3.06e-01
Ephrin signaling 19 1.88e-01 -0.175000 5.41e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.77e-01 -0.175000 5.39e-01
Signaling by PDGFRA extracellular domain mutants 12 2.95e-01 -0.175000 6.49e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.95e-01 -0.175000 6.49e-01
MET activates RAS signaling 11 3.17e-01 -0.174000 6.73e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 1.89e-01 0.174000 5.41e-01
Downstream signaling of activated FGFR4 18 2.03e-01 0.173000 5.62e-01
Glycosaminoglycan metabolism 110 1.69e-03 -0.173000 2.09e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 2.62e-01 -0.173000 6.26e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 2.31e-01 -0.173000 5.99e-01
Metalloprotease DUBs 19 1.94e-01 0.172000 5.44e-01
TNF signaling 57 2.47e-02 -0.172000 1.75e-01
Sema3A PAK dependent Axon repulsion 16 2.34e-01 -0.172000 6.03e-01
SHC1 events in ERBB4 signaling 12 3.04e-01 -0.171000 6.59e-01
RNA Polymerase III Transcription Termination 23 1.59e-01 0.170000 5.10e-01
Retrograde transport at the Trans-Golgi-Network 49 4.03e-02 -0.169000 2.35e-01
Response of EIF2AK1 (HRI) to heme deficiency 15 2.56e-01 0.169000 6.22e-01
RHO GTPases activate PAKs 21 1.80e-01 0.169000 5.41e-01
Leishmania infection 157 2.65e-04 -0.169000 5.11e-03
Parasitic Infection Pathways 157 2.65e-04 -0.169000 5.11e-03
Mitochondrial Fatty Acid Beta-Oxidation 34 8.87e-02 0.169000 3.78e-01
CaM pathway 31 1.04e-01 -0.169000 4.08e-01
Calmodulin induced events 31 1.04e-01 -0.169000 4.08e-01
RIP-mediated NFkB activation via ZBP1 17 2.30e-01 -0.168000 5.97e-01
Laminin interactions 28 1.24e-01 0.168000 4.49e-01
Signaling by NTRK3 (TRKC) 17 2.30e-01 -0.168000 5.97e-01
Receptor Mediated Mitophagy 11 3.36e-01 -0.168000 6.87e-01
Advanced glycosylation endproduct receptor signaling 12 3.15e-01 -0.168000 6.68e-01
Signaling by SCF-KIT 42 6.15e-02 -0.167000 3.03e-01
Meiotic synapsis 33 9.74e-02 0.167000 4.03e-01
Josephin domain DUBs 10 3.61e-01 0.167000 7.00e-01
Innate Immune System 899 3.95e-17 -0.166000 2.44e-15
Transport of Ribonucleoproteins into the Host Nucleus 32 1.04e-01 -0.166000 4.08e-01
Attachment and Entry 9694614 16 2.51e-01 -0.166000 6.19e-01
Mitochondrial iron-sulfur cluster biogenesis 13 3.02e-01 0.166000 6.55e-01
BBSome-mediated cargo-targeting to cilium 21 1.90e-01 0.165000 5.41e-01
Regulation of TNFR1 signaling 48 4.78e-02 -0.165000 2.59e-01
Translesion synthesis by REV1 16 2.54e-01 0.165000 6.19e-01
Budding and maturation of HIV virion 27 1.38e-01 0.165000 4.78e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 26 1.46e-01 -0.165000 4.88e-01
Trafficking of AMPA receptors 26 1.46e-01 -0.165000 4.88e-01
Golgi Associated Vesicle Biogenesis 55 3.48e-02 -0.165000 2.14e-01
Assembly and cell surface presentation of NMDA receptors 36 8.90e-02 0.164000 3.78e-01
GRB2 events in ERBB2 signaling 14 2.89e-01 -0.164000 6.47e-01
Negative regulators of DDX58/IFIH1 signaling 34 9.89e-02 -0.164000 4.04e-01
FGFR2 mutant receptor activation 24 1.66e-01 0.163000 5.19e-01
Cargo recognition for clathrin-mediated endocytosis 94 6.34e-03 -0.163000 6.23e-02
Signaling by KIT in disease 20 2.08e-01 -0.163000 5.68e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.08e-01 -0.163000 5.68e-01
Transport of bile salts and organic acids, metal ions and amine compounds 47 5.41e-02 -0.162000 2.76e-01
The NLRP3 inflammasome 16 2.61e-01 -0.162000 6.26e-01
Cargo concentration in the ER 30 1.24e-01 -0.162000 4.49e-01
Triglyceride metabolism 25 1.62e-01 -0.161000 5.14e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 23 1.80e-01 0.161000 5.41e-01
CLEC7A (Dectin-1) induces NFAT activation 11 3.56e-01 0.161000 6.95e-01
Collagen chain trimerization 39 8.31e-02 -0.160000 3.62e-01
NOD1/2 Signaling Pathway 36 9.63e-02 -0.160000 4.02e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 2.53e-01 -0.160000 6.19e-01
FRS-mediated FGFR3 signaling 14 3.01e-01 0.160000 6.55e-01
Synthesis of PIPs at the early endosome membrane 16 2.70e-01 -0.159000 6.38e-01
Transport of connexons to the plasma membrane 14 3.02e-01 0.159000 6.55e-01
Metabolism of amino acids and derivatives 320 1.04e-06 0.159000 3.57e-05
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 1.77e-01 0.159000 5.39e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 1.77e-01 0.159000 5.39e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 24 1.77e-01 0.159000 5.39e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 24 1.77e-01 0.159000 5.39e-01
Mitochondrial tRNA aminoacylation 21 2.07e-01 -0.159000 5.68e-01
NRAGE signals death through JNK 56 3.97e-02 -0.159000 2.33e-01
Tryptophan catabolism 12 3.41e-01 -0.159000 6.87e-01
TP53 Regulates Transcription of Cell Death Genes 41 7.91e-02 -0.159000 3.52e-01
Translesion synthesis by POLK 17 2.58e-01 0.158000 6.24e-01
The activation of arylsulfatases 10 3.86e-01 -0.158000 7.14e-01
Metabolism of Angiotensinogen to Angiotensins 15 2.89e-01 -0.158000 6.47e-01
Sulfur amino acid metabolism 23 1.89e-01 -0.158000 5.41e-01
G-protein mediated events 49 5.58e-02 -0.158000 2.81e-01
Antimicrobial peptides 30 1.35e-01 0.158000 4.69e-01
Neutrophil degranulation 444 1.38e-08 -0.157000 5.53e-07
Estrogen-dependent gene expression 93 8.79e-03 0.157000 7.99e-02
RNA Polymerase III Chain Elongation 18 2.48e-01 0.157000 6.15e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 5.24e-02 -0.157000 2.72e-01
Complex I biogenesis 51 5.28e-02 0.157000 2.72e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 2.26e-01 -0.157000 5.96e-01
Protein ubiquitination 64 3.07e-02 0.156000 2.00e-01
Beta-oxidation of very long chain fatty acids 10 3.93e-01 -0.156000 7.20e-01
Glutathione synthesis and recycling 11 3.72e-01 -0.156000 7.02e-01
Metabolism of folate and pterines 17 2.69e-01 -0.155000 6.38e-01
Immune System 1683 1.33e-25 -0.155000 1.41e-23
Transport of Mature mRNA Derived from an Intronless Transcript 42 8.49e-02 -0.154000 3.67e-01
Purine catabolism 13 3.38e-01 0.154000 6.87e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 13 3.39e-01 -0.153000 6.87e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 3.39e-01 -0.153000 6.87e-01
FRS-mediated FGFR2 signaling 16 2.91e-01 0.153000 6.47e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 1.63e-01 0.152000 5.14e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 71 2.67e-02 -0.152000 1.85e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 8.52e-02 -0.152000 3.67e-01
Signal regulatory protein family interactions 12 3.63e-01 -0.152000 7.00e-01
Nucleotide biosynthesis 12 3.63e-01 -0.152000 7.00e-01
RUNX2 regulates osteoblast differentiation 23 2.09e-01 -0.151000 5.69e-01
DAG and IP3 signaling 37 1.11e-01 -0.151000 4.22e-01
Formation of the cornified envelope 30 1.52e-01 -0.151000 4.96e-01
Keratinization 30 1.52e-01 -0.151000 4.96e-01
Signaling by FGFR2 in disease 34 1.27e-01 0.151000 4.54e-01
Acyl chain remodelling of PG 12 3.68e-01 -0.150000 7.00e-01
tRNA Aminoacylation 42 9.22e-02 -0.150000 3.91e-01
Glycerophospholipid biosynthesis 105 7.89e-03 -0.150000 7.51e-02
G0 and Early G1 25 1.94e-01 -0.150000 5.44e-01
Pyroptosis 23 2.14e-01 -0.150000 5.76e-01
Transcriptional Regulation by NPAS4 31 1.50e-01 0.150000 4.93e-01
TICAM1-dependent activation of IRF3/IRF7 12 3.70e-01 -0.149000 7.00e-01
Signaling by Insulin receptor 65 3.74e-02 -0.149000 2.25e-01
Regulation of NF-kappa B signaling 18 2.74e-01 -0.149000 6.40e-01
MHC class II antigen presentation 98 1.09e-02 -0.149000 9.17e-02
Drug ADME 60 4.64e-02 -0.149000 2.57e-01
HDMs demethylate histones 21 2.39e-01 -0.149000 6.05e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 33 1.40e-01 0.149000 4.80e-01
Pyruvate metabolism 27 1.82e-01 -0.148000 5.41e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 8.52e-02 -0.148000 3.67e-01
Vitamin B5 (pantothenate) metabolism 17 2.90e-01 -0.148000 6.47e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 1.62e-01 0.148000 5.14e-01
Rev-mediated nuclear export of HIV RNA 35 1.31e-01 -0.147000 4.64e-01
STAT3 nuclear events downstream of ALK signaling 10 4.21e-01 -0.147000 7.34e-01
Synthesis of pyrophosphates in the cytosol 10 4.21e-01 -0.147000 7.34e-01
Meiotic recombination 27 1.87e-01 0.147000 5.41e-01
Transport of the SLBP independent Mature mRNA 35 1.34e-01 -0.147000 4.68e-01
Adaptive Immune System 672 1.25e-10 -0.146000 5.44e-09
RORA activates gene expression 18 2.87e-01 -0.145000 6.47e-01
SLC-mediated transmembrane transport 161 1.52e-03 -0.145000 2.00e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 4.29e-01 -0.145000 7.35e-01
Transport of the SLBP Dependant Mature mRNA 36 1.34e-01 -0.144000 4.68e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.88e-01 -0.144000 7.16e-01
RAF-independent MAPK1/3 activation 22 2.43e-01 0.144000 6.09e-01
Regulation of IFNG signaling 13 3.69e-01 -0.144000 7.00e-01
Depolymerization of the Nuclear Lamina 15 3.37e-01 -0.143000 6.87e-01
Platelet degranulation 111 9.20e-03 -0.143000 8.13e-02
Negative regulation of FGFR4 signaling 22 2.45e-01 0.143000 6.12e-01
SHC-mediated cascade:FGFR4 11 4.11e-01 0.143000 7.33e-01
Nuclear signaling by ERBB4 29 1.83e-01 -0.143000 5.41e-01
RND1 GTPase cycle 38 1.27e-01 0.143000 4.54e-01
Synthesis of PC 24 2.28e-01 -0.142000 5.97e-01
Synthesis of bile acids and bile salts 26 2.09e-01 0.142000 5.69e-01
Defective pyroptosis 20 2.71e-01 0.142000 6.38e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 2.30e-01 0.142000 5.97e-01
Peroxisomal lipid metabolism 26 2.13e-01 -0.141000 5.75e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 3.14e-01 -0.141000 6.68e-01
Impaired BRCA2 binding to PALB2 23 2.41e-01 0.141000 6.08e-01
Regulation of localization of FOXO transcription factors 12 3.98e-01 0.141000 7.24e-01
HIV Transcription Initiation 45 1.02e-01 0.141000 4.04e-01
RNA Polymerase II HIV Promoter Escape 45 1.02e-01 0.141000 4.04e-01
RNA Polymerase II Promoter Escape 45 1.02e-01 0.141000 4.04e-01
RNA Polymerase II Transcription Initiation 45 1.02e-01 0.141000 4.04e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.02e-01 0.141000 4.04e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.02e-01 0.141000 4.04e-01
RET signaling 32 1.69e-01 -0.141000 5.24e-01
NoRC negatively regulates rRNA expression 53 7.73e-02 0.140000 3.47e-01
Iron uptake and transport 55 7.22e-02 -0.140000 3.35e-01
Signaling by Erythropoietin 24 2.36e-01 -0.140000 6.03e-01
Chemokine receptors bind chemokines 37 1.42e-01 -0.140000 4.82e-01
Signaling by FGFR2 IIIa TM 19 2.92e-01 0.140000 6.49e-01
Nuclear Events (kinase and transcription factor activation) 57 6.94e-02 0.139000 3.32e-01
Mismatch Repair 14 3.68e-01 0.139000 7.00e-01
Miscellaneous transport and binding events 21 2.70e-01 -0.139000 6.38e-01
Calnexin/calreticulin cycle 26 2.24e-01 -0.138000 5.92e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 4.09e-01 -0.138000 7.33e-01
Response to elevated platelet cytosolic Ca2+ 115 1.09e-02 -0.138000 9.17e-02
Diseases associated with O-glycosylation of proteins 56 7.54e-02 -0.137000 3.44e-01
RHOU GTPase cycle 39 1.39e-01 -0.137000 4.78e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.80e-01 -0.137000 5.41e-01
Stimuli-sensing channels 75 4.06e-02 -0.137000 2.36e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 3.94e-01 0.137000 7.20e-01
Eicosanoid ligand-binding receptors 14 3.76e-01 -0.137000 7.05e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 3.78e-01 -0.136000 7.06e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 72 4.61e-02 -0.136000 2.57e-01
G beta:gamma signalling through PI3Kgamma 21 2.81e-01 -0.136000 6.44e-01
Unblocking of NMDA receptors, glutamate binding and activation 20 2.94e-01 0.136000 6.49e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.66e-01 -0.135000 5.19e-01
Phospholipid metabolism 183 1.62e-03 -0.135000 2.02e-02
CTLA4 inhibitory signaling 19 3.08e-01 -0.135000 6.63e-01
Processing of SMDT1 15 3.65e-01 0.135000 7.00e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.87e-01 -0.135000 5.41e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.87e-01 -0.135000 5.41e-01
Phase 0 - rapid depolarisation 24 2.54e-01 0.135000 6.19e-01
Elastic fibre formation 40 1.42e-01 -0.134000 4.82e-01
The canonical retinoid cycle in rods (twilight vision) 12 4.21e-01 -0.134000 7.34e-01
FRS-mediated FGFR1 signaling 15 3.69e-01 0.134000 7.00e-01
Signaling by FLT3 ITD and TKD mutants 15 3.70e-01 0.134000 7.00e-01
Diseases of glycosylation 128 9.29e-03 -0.133000 8.15e-02
Ras activation upon Ca2+ influx through NMDA receptor 18 3.28e-01 0.133000 6.83e-01
NS1 Mediated Effects on Host Pathways 40 1.46e-01 -0.133000 4.88e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 89 3.04e-02 -0.133000 2.00e-01
Recognition of DNA damage by PCNA-containing replication complex 30 2.08e-01 0.133000 5.68e-01
Metabolism of RNA 694 2.98e-09 0.133000 1.26e-07
Vpr-mediated nuclear import of PICs 34 1.81e-01 -0.133000 5.41e-01
Platelet activation, signaling and aggregation 229 5.63e-04 -0.132000 1.01e-02
SHC1 events in ERBB2 signaling 20 3.06e-01 -0.132000 6.61e-01
CRMPs in Sema3A signaling 15 3.76e-01 -0.132000 7.05e-01
Cytosolic sulfonation of small molecules 18 3.33e-01 -0.132000 6.87e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 4.50e-01 0.132000 7.53e-01
WNT ligand biogenesis and trafficking 17 3.48e-01 0.132000 6.91e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 30 2.13e-01 0.132000 5.75e-01
Effects of PIP2 hydrolysis 24 2.67e-01 -0.131000 6.35e-01
Signaling by PDGF 54 9.63e-02 -0.131000 4.02e-01
TNFR2 non-canonical NF-kB pathway 90 3.22e-02 -0.131000 2.04e-01
Pyrimidine salvage 10 4.75e-01 -0.131000 7.71e-01
Signaling by NTRK2 (TRKB) 23 2.79e-01 -0.131000 6.43e-01
Downstream signaling of activated FGFR3 19 3.25e-01 0.130000 6.80e-01
Metabolic disorders of biological oxidation enzymes 24 2.70e-01 -0.130000 6.38e-01
TRAF6 mediated NF-kB activation 23 2.81e-01 -0.130000 6.44e-01
Bacterial Infection Pathways 65 7.04e-02 -0.130000 3.33e-01
RNA Polymerase I Transcription Termination 30 2.19e-01 0.130000 5.85e-01
Killing mechanisms 10 4.79e-01 -0.129000 7.71e-01
WNT5:FZD7-mediated leishmania damping 10 4.79e-01 -0.129000 7.71e-01
ERBB2 Activates PTK6 Signaling 11 4.59e-01 -0.129000 7.59e-01
ADP signalling through P2Y purinoceptor 1 21 3.08e-01 -0.129000 6.63e-01
Cytochrome c-mediated apoptotic response 13 4.22e-01 -0.129000 7.34e-01
Downstream signaling of activated FGFR2 21 3.10e-01 0.128000 6.65e-01
Transcription of E2F targets under negative control by DREAM complex 18 3.48e-01 -0.128000 6.91e-01
Physiological factors 10 4.86e-01 0.127000 7.75e-01
Signaling by Leptin 11 4.66e-01 0.127000 7.65e-01
Regulation of TP53 Activity through Methylation 19 3.41e-01 -0.126000 6.87e-01
Death Receptor Signaling 149 7.87e-03 -0.126000 7.51e-02
EGFR downregulation 29 2.40e-01 -0.126000 6.06e-01
Signaling by VEGF 105 2.63e-02 -0.126000 1.83e-01
IRF3-mediated induction of type I IFN 12 4.52e-01 -0.125000 7.53e-01
ER-Phagosome pathway 79 5.50e-02 -0.125000 2.79e-01
Asparagine N-linked glycosylation 281 3.25e-04 -0.125000 6.18e-03
Interactions of Rev with host cellular proteins 37 1.90e-01 -0.124000 5.41e-01
Cell death signalling via NRAGE, NRIF and NADE 73 6.64e-02 -0.124000 3.23e-01
Signaling by ALK 26 2.74e-01 -0.124000 6.40e-01
Diseases of metabolism 210 2.00e-03 -0.124000 2.41e-02
Synthesis of PIPs at the late endosome membrane 11 4.77e-01 -0.124000 7.71e-01
Interleukin-6 family signaling 22 3.15e-01 0.124000 6.68e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 15 4.07e-01 0.124000 7.33e-01
Negative regulation of MET activity 20 3.41e-01 -0.123000 6.87e-01
G alpha (12/13) signalling events 71 7.35e-02 -0.123000 3.38e-01
Activation of G protein gated Potassium channels 21 3.30e-01 0.123000 6.83e-01
G protein gated Potassium channels 21 3.30e-01 0.123000 6.83e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 21 3.30e-01 0.123000 6.83e-01
Clathrin-mediated endocytosis 133 1.47e-02 -0.123000 1.18e-01
IL-6-type cytokine receptor ligand interactions 15 4.11e-01 0.123000 7.33e-01
B-WICH complex positively regulates rRNA expression 38 1.92e-01 0.122000 5.42e-01
Nuclear Envelope Breakdown 53 1.25e-01 -0.122000 4.50e-01
Downstream signaling of activated FGFR1 21 3.35e-01 0.122000 6.87e-01
Interactions of Vpr with host cellular proteins 37 2.01e-01 -0.121000 5.59e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 4.16e-01 -0.121000 7.34e-01
Basigin interactions 22 3.25e-01 -0.121000 6.80e-01
Signaling by FGFR4 in disease 10 5.07e-01 0.121000 7.89e-01
Cytokine Signaling in Immune system 603 4.10e-07 -0.121000 1.52e-05
COPI-independent Golgi-to-ER retrograde traffic 45 1.60e-01 0.121000 5.11e-01
Signaling by EGFR 48 1.47e-01 -0.121000 4.90e-01
Interleukin-20 family signaling 14 4.35e-01 -0.121000 7.39e-01
Negative epigenetic regulation of rRNA expression 56 1.19e-01 0.120000 4.41e-01
Receptor-type tyrosine-protein phosphatases 13 4.53e-01 0.120000 7.53e-01
RUNX2 regulates bone development 29 2.63e-01 -0.120000 6.29e-01
SARS-CoV-1 activates/modulates innate immune responses 40 1.89e-01 -0.120000 5.41e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.48e-01 0.120000 6.15e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 5.12e-01 0.120000 7.92e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.15e-01 0.119000 7.94e-01
Synthesis of substrates in N-glycan biosythesis 57 1.21e-01 -0.119000 4.47e-01
VxPx cargo-targeting to cilium 17 3.99e-01 -0.118000 7.25e-01
Chaperonin-mediated protein folding 78 7.14e-02 0.118000 3.35e-01
Vesicle-mediated transport 617 5.96e-07 -0.118000 2.15e-05
NPAS4 regulates expression of target genes 19 3.74e-01 0.118000 7.03e-01
CD209 (DC-SIGN) signaling 20 3.62e-01 -0.118000 7.00e-01
Intrinsic Pathway for Apoptosis 54 1.35e-01 -0.118000 4.69e-01
PKA activation in glucagon signalling 15 4.31e-01 -0.117000 7.36e-01
Regulation of MECP2 expression and activity 29 2.74e-01 -0.117000 6.40e-01
Listeria monocytogenes entry into host cells 18 3.89e-01 -0.117000 7.16e-01
TBC/RABGAPs 44 1.79e-01 -0.117000 5.39e-01
Ion transport by P-type ATPases 43 1.86e-01 0.117000 5.41e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 1.02e-01 -0.117000 4.04e-01
Transport of small molecules 540 4.06e-06 -0.116000 1.23e-04
Activation of BAD and translocation to mitochondria 15 4.36e-01 0.116000 7.41e-01
SARS-CoV-1 Infection 137 2.01e-02 0.115000 1.50e-01
Inwardly rectifying K+ channels 24 3.30e-01 0.115000 6.83e-01
Defective Intrinsic Pathway for Apoptosis 21 3.63e-01 -0.115000 7.00e-01
Regulation of signaling by CBL 22 3.52e-01 -0.115000 6.94e-01
DNA Damage/Telomere Stress Induced Senescence 34 2.47e-01 0.115000 6.15e-01
Assembly Of The HIV Virion 16 4.27e-01 0.115000 7.35e-01
Molecules associated with elastic fibres 33 2.55e-01 -0.114000 6.21e-01
Hemostasis 504 1.15e-05 -0.114000 3.05e-04
Autophagy 139 2.02e-02 0.114000 1.50e-01
Ion channel transport 137 2.13e-02 -0.114000 1.55e-01
SUMOylation of SUMOylation proteins 35 2.44e-01 -0.114000 6.10e-01
Nuclear import of Rev protein 34 2.53e-01 -0.113000 6.19e-01
Nervous system development 517 1.14e-05 0.113000 3.05e-04
PI Metabolism 79 8.30e-02 -0.113000 3.62e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 4.21e-01 -0.113000 7.34e-01
Sphingolipid de novo biosynthesis 36 2.43e-01 0.112000 6.10e-01
Macroautophagy 124 3.10e-02 0.112000 2.00e-01
Signaling by FGFR4 32 2.72e-01 0.112000 6.39e-01
Glycogen metabolism 24 3.42e-01 0.112000 6.87e-01
Platelet sensitization by LDL 17 4.24e-01 -0.112000 7.34e-01
Initiation of Nuclear Envelope (NE) Reformation 19 4.02e-01 0.111000 7.29e-01
FLT3 signaling in disease 27 3.18e-01 0.111000 6.73e-01
Toll-like Receptor Cascades 158 1.63e-02 -0.111000 1.30e-01
Anchoring fibril formation 12 5.08e-01 -0.110000 7.89e-01
ABC-family proteins mediated transport 90 7.12e-02 -0.110000 3.35e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 41 2.23e-01 0.110000 5.92e-01
Synthesis of PA 32 2.82e-01 -0.110000 6.44e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 4.47e-01 -0.110000 7.53e-01
Uptake and actions of bacterial toxins 25 3.42e-01 -0.110000 6.87e-01
Transcriptional activation of mitochondrial biogenesis 49 1.84e-01 -0.110000 5.41e-01
RNA Polymerase I Promoter Clearance 57 1.53e-01 0.109000 4.96e-01
RNA Polymerase I Transcription 57 1.53e-01 0.109000 4.96e-01
Cytosolic tRNA aminoacylation 24 3.55e-01 -0.109000 6.95e-01
Negative regulation of FGFR3 signaling 23 3.66e-01 0.109000 7.00e-01
Activation of GABAB receptors 33 2.79e-01 0.109000 6.43e-01
GABA B receptor activation 33 2.79e-01 0.109000 6.43e-01
Neurexins and neuroligins 46 2.01e-01 -0.109000 5.60e-01
Branched-chain amino acid catabolism 21 3.89e-01 -0.109000 7.16e-01
Axon guidance 496 3.64e-05 0.109000 8.70e-04
Negative regulation of FGFR2 signaling 25 3.48e-01 0.108000 6.91e-01
Sensory Perception 159 1.85e-02 0.108000 1.43e-01
Regulated proteolysis of p75NTR 11 5.34e-01 -0.108000 8.04e-01
Signalling to ERKs 33 2.82e-01 -0.108000 6.44e-01
Potential therapeutics for SARS 100 6.24e-02 -0.108000 3.06e-01
Meiosis 52 1.78e-01 0.108000 5.39e-01
VEGFA-VEGFR2 Pathway 96 6.87e-02 -0.108000 3.31e-01
Protein folding 84 8.88e-02 0.107000 3.78e-01
Host Interactions of HIV factors 127 3.67e-02 -0.107000 2.24e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 4.18e-01 0.107000 7.34e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 4.19e-01 0.107000 7.34e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 4.73e-01 0.107000 7.71e-01
p75 NTR receptor-mediated signalling 93 7.51e-02 -0.107000 3.44e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 5.40e-01 0.107000 8.09e-01
Ca2+ pathway 55 1.72e-01 0.106000 5.32e-01
Respiratory electron transport 93 7.64e-02 0.106000 3.44e-01
Amine ligand-binding receptors 11 5.43e-01 0.106000 8.12e-01
Keratan sulfate/keratin metabolism 32 3.00e-01 -0.106000 6.55e-01
Heme biosynthesis 13 5.10e-01 0.106000 7.90e-01
CDC42 GTPase cycle 146 2.82e-02 -0.105000 1.90e-01
Chromosome Maintenance 93 7.95e-02 0.105000 3.53e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 5.28e-01 0.105000 8.01e-01
Interleukin-12 family signaling 47 2.14e-01 -0.105000 5.76e-01
APC-Cdc20 mediated degradation of Nek2A 26 3.56e-01 0.105000 6.95e-01
CS/DS degradation 11 5.49e-01 -0.104000 8.17e-01
Rap1 signalling 14 5.00e-01 -0.104000 7.89e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 5.18e-01 0.104000 7.96e-01
Formation of ATP by chemiosmotic coupling 16 4.74e-01 0.103000 7.71e-01
Telomere Maintenance 70 1.36e-01 0.103000 4.70e-01
Export of Viral Ribonucleoproteins from Nucleus 33 3.06e-01 -0.103000 6.61e-01
Processive synthesis on the C-strand of the telomere 19 4.37e-01 0.103000 7.41e-01
RNA Polymerase II Pre-transcription Events 77 1.19e-01 0.103000 4.41e-01
Signaling by high-kinase activity BRAF mutants 32 3.14e-01 -0.103000 6.68e-01
Mitophagy 28 3.47e-01 0.103000 6.91e-01
Sphingolipid metabolism 72 1.32e-01 -0.103000 4.65e-01
Acyl chain remodelling of PE 20 4.27e-01 -0.103000 7.35e-01
Late endosomal microautophagy 31 3.24e-01 0.102000 6.80e-01
O-glycosylation of TSR domain-containing proteins 36 2.90e-01 -0.102000 6.47e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 3.88e-01 0.102000 7.16e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 4.83e-01 0.101000 7.72e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 3.71e-01 0.101000 7.01e-01
Removal of the Flap Intermediate from the C-strand 17 4.70e-01 0.101000 7.70e-01
Intrinsic Pathway of Fibrin Clot Formation 12 5.44e-01 0.101000 8.12e-01
Amyloid fiber formation 43 2.52e-01 -0.101000 6.19e-01
Pentose phosphate pathway 13 5.29e-01 -0.101000 8.01e-01
Signaling by RAF1 mutants 37 2.90e-01 -0.101000 6.47e-01
ESR-mediated signaling 158 2.99e-02 0.100000 1.99e-01
Assembly of the pre-replicative complex 90 1.01e-01 0.100000 4.04e-01
Notch-HLH transcription pathway 28 3.60e-01 -0.099900 7.00e-01
Arachidonic acid metabolism 37 2.95e-01 -0.099600 6.49e-01
TAK1-dependent IKK and NF-kappa-B activation 43 2.62e-01 -0.098900 6.26e-01
G alpha (i) signalling events 187 2.00e-02 -0.098800 1.49e-01
EPHB-mediated forward signaling 41 2.74e-01 -0.098800 6.40e-01
Transcriptional Regulation by E2F6 34 3.20e-01 0.098700 6.74e-01
A tetrasaccharide linker sequence is required for GAG synthesis 22 4.23e-01 -0.098600 7.34e-01
ADP signalling through P2Y purinoceptor 12 17 4.82e-01 0.098500 7.72e-01
COPI-dependent Golgi-to-ER retrograde traffic 88 1.11e-01 -0.098300 4.22e-01
Membrane Trafficking 581 5.53e-05 -0.098200 1.30e-03
Interconversion of nucleotide di- and triphosphates 27 3.79e-01 0.097900 7.06e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 7.36e-02 0.097500 3.38e-01
Defects in vitamin and cofactor metabolism 20 4.53e-01 0.097000 7.53e-01
Transport of Mature Transcript to Cytoplasm 81 1.31e-01 -0.097000 4.64e-01
RHO GTPases activate KTN1 10 5.96e-01 -0.096800 8.50e-01
Senescence-Associated Secretory Phenotype (SASP) 57 2.07e-01 0.096700 5.68e-01
mRNA Capping 29 3.69e-01 0.096300 7.00e-01
Cilium Assembly 187 2.34e-02 0.096300 1.67e-01
O-linked glycosylation 89 1.17e-01 -0.096200 4.39e-01
Infection with Mycobacterium tuberculosis 27 3.89e-01 -0.095800 7.16e-01
Platelet Aggregation (Plug Formation) 32 3.50e-01 -0.095600 6.91e-01
PKA-mediated phosphorylation of CREB 18 4.84e-01 -0.095400 7.72e-01
Extracellular matrix organization 258 9.19e-03 -0.094300 8.13e-02
Activation of NMDA receptors and postsynaptic events 80 1.45e-01 0.094300 4.88e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.98e-01 0.094100 7.24e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.98e-01 0.094100 7.24e-01
MASTL Facilitates Mitotic Progression 10 6.08e-01 0.093700 8.54e-01
STING mediated induction of host immune responses 15 5.30e-01 -0.093700 8.01e-01
NRIF signals cell death from the nucleus 16 5.18e-01 0.093300 7.96e-01
SUMOylation of transcription factors 17 5.06e-01 -0.093300 7.89e-01
Transcription of the HIV genome 67 1.87e-01 0.093200 5.41e-01
Transport to the Golgi and subsequent modification 168 3.73e-02 -0.093200 2.25e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 187 2.83e-02 -0.093100 1.90e-01
Peptide hormone metabolism 56 2.30e-01 -0.092800 5.97e-01
Prolactin receptor signaling 11 5.98e-01 -0.091900 8.50e-01
Signaling by BRAF and RAF1 fusions 59 2.25e-01 -0.091300 5.95e-01
Signaling by PDGFR in disease 20 4.80e-01 -0.091300 7.71e-01
Platelet calcium homeostasis 23 4.49e-01 -0.091300 7.53e-01
Long-term potentiation 22 4.59e-01 0.091100 7.59e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 5.70e-01 -0.091100 8.33e-01
mRNA 3’-end processing 57 2.35e-01 -0.091000 6.03e-01
Developmental Biology 803 1.29e-05 0.091000 3.29e-04
Interleukin-12 signaling 41 3.15e-01 -0.090700 6.68e-01
Class I MHC mediated antigen processing & presentation 346 4.20e-03 -0.089800 4.62e-02
Lewis blood group biosynthesis 10 6.23e-01 0.089700 8.60e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.88e-01 -0.089700 5.41e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 6.08e-01 -0.089300 8.54e-01
Signaling by FGFR2 61 2.29e-01 0.089200 5.97e-01
Signaling by FGFR3 34 3.69e-01 0.089000 7.00e-01
Signaling by Receptor Tyrosine Kinases 476 9.14e-04 -0.089000 1.44e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 3.78e-01 -0.088800 7.06e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.43e-01 0.088700 7.48e-01
Thromboxane signalling through TP receptor 20 4.92e-01 -0.088700 7.80e-01
Synthesis, secretion, and deacylation of Ghrelin 12 5.96e-01 0.088500 8.50e-01
SUMOylation of chromatin organization proteins 57 2.49e-01 -0.088300 6.16e-01
SLC transporter disorders 71 1.99e-01 -0.088300 5.55e-01
mRNA Splicing 210 2.79e-02 0.088100 1.90e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 3.49e-01 0.087800 6.91e-01
RND3 GTPase cycle 37 3.56e-01 0.087700 6.95e-01
Growth hormone receptor signaling 20 4.98e-01 -0.087600 7.87e-01
FOXO-mediated transcription 57 2.53e-01 0.087500 6.19e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 5.22e-01 -0.087200 7.98e-01
Neurodegenerative Diseases 18 5.22e-01 -0.087200 7.98e-01
Oncogenic MAPK signaling 75 1.93e-01 -0.087000 5.43e-01
MET activates RAP1 and RAC1 11 6.18e-01 0.086900 8.60e-01
Formation of Incision Complex in GG-NER 43 3.25e-01 0.086800 6.80e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 72 2.04e-01 0.086600 5.62e-01
Processing of Capped Intronless Pre-mRNA 29 4.21e-01 -0.086300 7.34e-01
Downstream signal transduction 28 4.30e-01 -0.086100 7.36e-01
Signal amplification 28 4.31e-01 -0.086100 7.36e-01
Frs2-mediated activation 12 6.08e-01 -0.085500 8.54e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.38e-01 0.085400 6.87e-01
HIV Transcription Elongation 42 3.38e-01 0.085400 6.87e-01
Tat-mediated elongation of the HIV-1 transcript 42 3.38e-01 0.085400 6.87e-01
GPCR downstream signalling 384 4.24e-03 -0.085200 4.62e-02
Nucleotide catabolism 24 4.72e-01 -0.084800 7.71e-01
NCAM1 interactions 32 4.07e-01 -0.084600 7.33e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 5.97e-01 0.084600 8.50e-01
Adenylate cyclase inhibitory pathway 12 6.12e-01 0.084600 8.59e-01
G alpha (z) signalling events 39 3.65e-01 0.083800 7.00e-01
Signaling by Interleukins 394 4.43e-03 -0.083700 4.73e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 84 1.87e-01 -0.083400 5.41e-01
RHO GTPases activate IQGAPs 24 4.80e-01 0.083400 7.71e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 70 2.29e-01 0.083200 5.97e-01
Viral Messenger RNA Synthesis 44 3.41e-01 -0.083100 6.87e-01
ERBB2 Regulates Cell Motility 13 6.06e-01 -0.082700 8.54e-01
Regulation of TP53 Activity through Acetylation 29 4.41e-01 -0.082600 7.47e-01
mRNA Splicing - Minor Pathway 50 3.13e-01 0.082600 6.68e-01
Anchoring of the basal body to the plasma membrane 96 1.62e-01 0.082600 5.14e-01
Diseases of DNA repair 48 3.24e-01 0.082300 6.80e-01
MAPK6/MAPK4 signaling 83 1.96e-01 0.082200 5.47e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 5.07e-01 -0.081700 7.89e-01
Formation of the Early Elongation Complex 33 4.17e-01 0.081600 7.34e-01
Formation of the HIV-1 Early Elongation Complex 33 4.17e-01 0.081600 7.34e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 4.12e-01 0.081300 7.34e-01
Positive epigenetic regulation of rRNA expression 53 3.06e-01 0.081300 6.61e-01
SHC-mediated cascade:FGFR2 14 5.99e-01 0.081200 8.51e-01
Cytoprotection by HMOX1 58 2.85e-01 -0.081100 6.47e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 4.92e-01 0.081100 7.80e-01
Defective B3GALTL causes PpS 35 4.07e-01 -0.081000 7.33e-01
Fanconi Anemia Pathway 35 4.08e-01 -0.080800 7.33e-01
Formation of RNA Pol II elongation complex 56 2.97e-01 0.080600 6.50e-01
RNA Polymerase II Transcription Elongation 56 2.97e-01 0.080600 6.50e-01
Deactivation of the beta-catenin transactivating complex 39 3.85e-01 0.080500 7.13e-01
tRNA modification in the nucleus and cytosol 43 3.62e-01 0.080300 7.00e-01
C-type lectin receptors (CLRs) 123 1.24e-01 -0.080300 4.50e-01
Signaling by cytosolic FGFR1 fusion mutants 18 5.56e-01 -0.080300 8.20e-01
Polymerase switching on the C-strand of the telomere 26 4.81e-01 0.079900 7.71e-01
Opioid Signalling 79 2.20e-01 -0.079900 5.85e-01
GABA receptor activation 41 3.76e-01 0.079900 7.05e-01
Integrin cell surface interactions 74 2.36e-01 -0.079800 6.03e-01
Signaling by FLT3 fusion proteins 19 5.48e-01 0.079600 8.16e-01
Bile acid and bile salt metabolism 30 4.52e-01 0.079300 7.53e-01
O-linked glycosylation of mucins 44 3.63e-01 -0.079300 7.00e-01
Rab regulation of trafficking 119 1.36e-01 -0.079300 4.70e-01
VEGFR2 mediated cell proliferation 19 5.50e-01 -0.079200 8.17e-01
mRNA Splicing - Major Pathway 202 5.35e-02 0.078900 2.75e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 64 2.75e-01 0.078900 6.40e-01
Reproduction 70 2.59e-01 0.078000 6.24e-01
Post-translational modification: synthesis of GPI-anchored proteins 63 2.84e-01 -0.078000 6.47e-01
GPER1 signaling 38 4.06e-01 -0.077900 7.33e-01
SHC-mediated cascade:FGFR3 12 6.41e-01 0.077600 8.70e-01
Sensory processing of sound by outer hair cells of the cochlea 41 3.90e-01 0.077600 7.16e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.73e-01 0.077600 7.03e-01
Detoxification of Reactive Oxygen Species 33 4.43e-01 -0.077200 7.48e-01
Phase 4 - resting membrane potential 11 6.58e-01 0.077100 8.80e-01
Regulation of BACH1 activity 11 6.59e-01 0.076800 8.81e-01
Factors involved in megakaryocyte development and platelet production 123 1.42e-01 -0.076700 4.82e-01
Telomere C-strand (Lagging Strand) Synthesis 34 4.41e-01 0.076400 7.47e-01
Retinoid metabolism and transport 30 4.70e-01 0.076200 7.70e-01
EPH-Ephrin signaling 86 2.23e-01 -0.076100 5.92e-01
Signaling by NODAL 13 6.37e-01 0.075500 8.70e-01
Diseases associated with glycosylation precursor biosynthesis 15 6.13e-01 -0.075400 8.59e-01
Pre-NOTCH Transcription and Translation 40 4.10e-01 0.075300 7.33e-01
DNA Replication Pre-Initiation 105 1.83e-01 0.075200 5.41e-01
Formation of TC-NER Pre-Incision Complex 53 3.45e-01 0.075000 6.89e-01
Regulation of RUNX1 Expression and Activity 18 5.84e-01 -0.074600 8.41e-01
Recruitment of NuMA to mitotic centrosomes 88 2.27e-01 0.074600 5.97e-01
Response of Mtb to phagocytosis 23 5.37e-01 -0.074400 8.07e-01
Post NMDA receptor activation events 68 2.89e-01 0.074400 6.47e-01
Response to metal ions 10 6.88e-01 -0.073400 8.88e-01
Recycling pathway of L1 41 4.18e-01 -0.073100 7.34e-01
ER to Golgi Anterograde Transport 143 1.32e-01 -0.073000 4.65e-01
Fc epsilon receptor (FCERI) signaling 133 1.48e-01 -0.072800 4.90e-01
Disorders of transmembrane transporters 139 1.39e-01 -0.072800 4.78e-01
Antiviral mechanism by IFN-stimulated genes 79 2.64e-01 -0.072800 6.29e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 4.20e-01 -0.072800 7.34e-01
Signaling by RAS mutants 41 4.20e-01 -0.072800 7.34e-01
Signaling by moderate kinase activity BRAF mutants 41 4.20e-01 -0.072800 7.34e-01
Signaling downstream of RAS mutants 41 4.20e-01 -0.072800 7.34e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 5.14e-01 -0.072600 7.93e-01
Regulation of PLK1 Activity at G2/M Transition 86 2.45e-01 0.072500 6.12e-01
Activation of HOX genes during differentiation 66 3.11e-01 0.072200 6.65e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 66 3.11e-01 0.072200 6.65e-01
Aquaporin-mediated transport 36 4.55e-01 0.072000 7.54e-01
IRAK2 mediated activation of TAK1 complex 10 6.95e-01 0.071600 8.94e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 6.44e-01 -0.071400 8.71e-01
Defective EXT2 causes exostoses 2 14 6.44e-01 -0.071400 8.71e-01
Cargo trafficking to the periciliary membrane 45 4.08e-01 0.071300 7.33e-01
Signaling by Retinoic Acid 35 4.66e-01 -0.071200 7.65e-01
RHOD GTPase cycle 50 3.85e-01 0.071100 7.13e-01
Gap junction assembly 21 5.74e-01 0.070800 8.37e-01
RMTs methylate histone arginines 33 4.83e-01 -0.070600 7.72e-01
Dual incision in TC-NER 65 3.29e-01 0.070100 6.83e-01
RHO GTPases Activate WASPs and WAVEs 35 4.77e-01 -0.069500 7.71e-01
mTORC1-mediated signalling 24 5.56e-01 0.069500 8.20e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 12 6.77e-01 0.069500 8.87e-01
Visual phototransduction 61 3.52e-01 0.068900 6.94e-01
Constitutive Signaling by Aberrant PI3K in Cancer 58 3.64e-01 -0.068900 7.00e-01
PI3K events in ERBB2 signaling 14 6.56e-01 -0.068800 8.80e-01
DNA Damage Bypass 46 4.21e-01 0.068600 7.34e-01
ISG15 antiviral mechanism 71 3.18e-01 -0.068600 6.73e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 3.43e-01 0.068500 6.87e-01
Metabolism of lipids 610 4.02e-03 -0.068500 4.55e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 18 6.15e-01 0.068400 8.59e-01
HATs acetylate histones 83 2.83e-01 0.068300 6.45e-01
PIWI-interacting RNA (piRNA) biogenesis 22 5.82e-01 0.067800 8.40e-01
Methylation 12 6.84e-01 0.067800 8.88e-01
RNA polymerase II transcribes snRNA genes 71 3.24e-01 0.067700 6.80e-01
IRS-related events triggered by IGF1R 38 4.71e-01 0.067600 7.70e-01
Carnitine metabolism 13 6.73e-01 0.067600 8.87e-01
FCERI mediated NF-kB activation 83 2.88e-01 -0.067500 6.47e-01
Acyl chain remodelling of PC 20 6.02e-01 -0.067400 8.52e-01
TCF dependent signaling in response to WNT 161 1.42e-01 0.067100 4.82e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 6.87e-01 -0.067100 8.88e-01
Synaptic adhesion-like molecules 19 6.14e-01 0.066900 8.59e-01
VEGFR2 mediated vascular permeability 27 5.48e-01 -0.066900 8.16e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 4.01e-01 0.066700 7.28e-01
Constitutive Signaling by EGFRvIII 15 6.55e-01 -0.066700 8.80e-01
Signaling by EGFRvIII in Cancer 15 6.55e-01 -0.066700 8.80e-01
Downregulation of ERBB2 signaling 27 5.50e-01 0.066400 8.17e-01
Formation of WDR5-containing histone-modifying complexes 42 4.57e-01 -0.066400 7.57e-01
Activation of the pre-replicative complex 31 5.23e-01 0.066300 7.98e-01
TP53 Regulates Transcription of DNA Repair Genes 61 3.74e-01 0.065800 7.03e-01
RHOA GTPase cycle 143 1.75e-01 -0.065700 5.39e-01
G alpha (q) signalling events 137 1.85e-01 -0.065700 5.41e-01
Nuclear Envelope (NE) Reassembly 68 3.49e-01 0.065600 6.91e-01
Surfactant metabolism 20 6.13e-01 0.065400 8.59e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 6.83e-01 -0.065300 8.88e-01
Negative regulation of the PI3K/AKT network 91 2.83e-01 -0.065200 6.45e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 2.56e-01 -0.065100 6.22e-01
Ovarian tumor domain proteases 36 5.00e-01 -0.065000 7.89e-01
Signaling by TGFB family members 113 2.33e-01 0.065000 6.00e-01
Chondroitin sulfate biosynthesis 16 6.53e-01 -0.064900 8.80e-01
Base Excision Repair 51 4.24e-01 0.064800 7.34e-01
Dopamine Neurotransmitter Release Cycle 22 5.99e-01 0.064800 8.51e-01
Toll Like Receptor 4 (TLR4) Cascade 138 1.90e-01 -0.064700 5.41e-01
Negative regulation of FGFR1 signaling 25 5.76e-01 0.064500 8.37e-01
Sialic acid metabolism 27 5.63e-01 -0.064300 8.26e-01
Cellular responses to stress 696 4.05e-03 0.064200 4.55e-02
G beta:gamma signalling through PLC beta 16 6.57e-01 -0.064200 8.80e-01
Non-integrin membrane-ECM interactions 55 4.11e-01 0.064100 7.33e-01
Nephrin family interactions 20 6.20e-01 0.064100 8.60e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 4.48e-01 0.064100 7.53e-01
Signaling by ERBB2 TMD/JMD mutants 20 6.21e-01 -0.063900 8.60e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 5.08e-01 0.063800 7.89e-01
Metabolism of fat-soluble vitamins 33 5.26e-01 0.063800 8.01e-01
Alpha-protein kinase 1 signaling pathway 11 7.16e-01 0.063400 9.08e-01
Early SARS-CoV-2 Infection Events 33 5.30e-01 -0.063200 8.01e-01
ATF6 (ATF6-alpha) activates chaperones 12 7.05e-01 -0.063200 9.02e-01
Resolution of D-Loop Structures 33 5.33e-01 -0.062700 8.04e-01
Resolution of Abasic Sites (AP sites) 38 5.07e-01 -0.062300 7.89e-01
Cellular responses to stimuli 706 5.02e-03 0.062300 5.28e-02
Signaling by GPCR 429 2.75e-02 -0.062200 1.89e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 6.15e-01 0.062000 8.59e-01
G-protein activation 19 6.40e-01 -0.061900 8.70e-01
CTNNB1 S33 mutants aren’t phosphorylated 15 6.79e-01 0.061700 8.87e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 6.79e-01 0.061700 8.87e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 6.79e-01 0.061700 8.87e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 6.79e-01 0.061700 8.87e-01
Signaling by CTNNB1 phospho-site mutants 15 6.79e-01 0.061700 8.87e-01
Signaling by GSK3beta mutants 15 6.79e-01 0.061700 8.87e-01
MyD88-independent TLR4 cascade 107 2.71e-01 -0.061600 6.38e-01
TRIF(TICAM1)-mediated TLR4 signaling 107 2.71e-01 -0.061600 6.38e-01
N-Glycan antennae elongation 13 7.01e-01 0.061500 9.00e-01
RHOQ GTPase cycle 57 4.24e-01 -0.061200 7.34e-01
Triglyceride catabolism 16 6.73e-01 -0.060900 8.87e-01
SARS-CoV-2 Infection 266 8.81e-02 -0.060900 3.77e-01
TGF-beta receptor signaling activates SMADs 45 4.80e-01 0.060800 7.71e-01
SUMOylation of RNA binding proteins 47 4.73e-01 -0.060600 7.71e-01
SARS-CoV Infections 384 4.26e-02 -0.060400 2.44e-01
Class B/2 (Secretin family receptors) 59 4.28e-01 0.059700 7.35e-01
Signaling by FGFR1 in disease 32 5.60e-01 0.059600 8.23e-01
Toll Like Receptor 9 (TLR9) Cascade 105 2.93e-01 -0.059400 6.49e-01
Signal transduction by L1 21 6.38e-01 -0.059400 8.70e-01
Signaling by CSF3 (G-CSF) 29 5.81e-01 -0.059200 8.40e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 5.23e-01 0.059100 7.98e-01
Diseases of DNA Double-Strand Break Repair 39 5.23e-01 0.059100 7.98e-01
Glutathione conjugation 30 5.76e-01 0.059100 8.37e-01
TCR signaling 106 2.94e-01 -0.059000 6.49e-01
Transcriptional regulation by RUNX1 169 1.86e-01 0.059000 5.41e-01
Pausing and recovery of Tat-mediated HIV elongation 30 5.78e-01 0.058800 8.37e-01
Tat-mediated HIV elongation arrest and recovery 30 5.78e-01 0.058800 8.37e-01
Signaling by ERBB4 52 4.64e-01 -0.058700 7.65e-01
Lysine catabolism 11 7.38e-01 -0.058400 9.14e-01
Separation of Sister Chromatids 176 1.85e-01 0.058000 5.41e-01
Mitotic Prophase 89 3.45e-01 -0.058000 6.89e-01
Activation of kainate receptors upon glutamate binding 24 6.23e-01 0.058000 8.60e-01
Cell-extracellular matrix interactions 18 6.71e-01 -0.057800 8.87e-01
G alpha (s) signalling events 91 3.41e-01 -0.057800 6.87e-01
RAC1 GTPase cycle 173 1.91e-01 -0.057700 5.41e-01
Resolution of Sister Chromatid Cohesion 113 2.91e-01 0.057600 6.47e-01
Mitotic Telophase/Cytokinesis 13 7.20e-01 0.057500 9.08e-01
Golgi-to-ER retrograde transport 121 2.75e-01 -0.057500 6.40e-01
PCP/CE pathway 88 3.53e-01 -0.057300 6.95e-01
Mitotic Metaphase and Anaphase 220 1.45e-01 0.057100 4.88e-01
TP53 Regulates Transcription of Cell Cycle Genes 44 5.12e-01 -0.057100 7.92e-01
Signaling by FGFR 70 4.10e-01 0.057000 7.33e-01
Glucagon signaling in metabolic regulation 26 6.16e-01 -0.056900 8.59e-01
Regulation of PTEN gene transcription 59 4.51e-01 0.056700 7.53e-01
Mitotic Anaphase 219 1.49e-01 0.056700 4.91e-01
RNA Polymerase I Transcription Initiation 47 5.03e-01 0.056500 7.89e-01
PERK regulates gene expression 32 5.80e-01 0.056500 8.40e-01
MyD88 dependent cascade initiated on endosome 101 3.27e-01 -0.056500 6.82e-01
Loss of Nlp from mitotic centrosomes 68 4.22e-01 0.056300 7.34e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 4.22e-01 0.056300 7.34e-01
Activation of RAC1 11 7.46e-01 -0.056300 9.17e-01
TP53 Regulates Metabolic Genes 80 3.85e-01 0.056200 7.13e-01
RNA Polymerase III Abortive And Retractive Initiation 41 5.35e-01 0.056100 8.04e-01
RNA Polymerase III Transcription 41 5.35e-01 0.056100 8.04e-01
ABC transporter disorders 68 4.25e-01 -0.056000 7.35e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 6.36e-01 0.055800 8.70e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 5.14e-01 -0.055700 7.93e-01
Hedgehog ‘off’ state 105 3.26e-01 0.055500 6.82e-01
HS-GAG biosynthesis 25 6.33e-01 -0.055200 8.67e-01
Interleukin-6 signaling 11 7.52e-01 0.055100 9.19e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 7.41e-01 0.055100 9.16e-01
Dissolution of Fibrin Clot 10 7.63e-01 -0.055000 9.24e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 30 6.03e-01 0.054800 8.53e-01
Formation of Fibrin Clot (Clotting Cascade) 21 6.64e-01 0.054800 8.83e-01
CLEC7A (Dectin-1) signaling 96 3.54e-01 -0.054700 6.95e-01
Organelle biogenesis and maintenance 272 1.21e-01 0.054700 4.47e-01
RAC2 GTPase cycle 85 3.85e-01 -0.054600 7.13e-01
Negative regulation of MAPK pathway 42 5.41e-01 0.054500 8.11e-01
Cellular response to chemical stress 184 2.03e-01 -0.054400 5.62e-01
Toll Like Receptor 3 (TLR3) Cascade 103 3.41e-01 -0.054300 6.87e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 4.53e-01 0.054200 7.53e-01
SHC-mediated cascade:FGFR1 13 7.35e-01 0.054100 9.14e-01
Gap junction trafficking 32 5.96e-01 -0.054100 8.50e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 7.57e-01 0.054000 9.19e-01
Incretin synthesis, secretion, and inactivation 13 7.38e-01 0.053700 9.14e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 7.38e-01 0.053700 9.14e-01
Regulation of lipid metabolism by PPARalpha 107 3.43e-01 -0.053100 6.87e-01
Inositol phosphate metabolism 45 5.38e-01 -0.053100 8.08e-01
Interleukin-37 signaling 20 6.81e-01 -0.053000 8.88e-01
PKA activation 16 7.14e-01 -0.052800 9.08e-01
RA biosynthesis pathway 15 7.23e-01 0.052800 9.08e-01
Peroxisomal protein import 57 4.93e-01 -0.052500 7.80e-01
Cellular response to heat stress 96 3.79e-01 0.052000 7.06e-01
RNA Polymerase II Transcription Termination 66 4.66e-01 -0.051900 7.65e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 6.24e-01 0.051700 8.60e-01
Gastrulation 85 4.14e-01 0.051300 7.34e-01
Centrosome maturation 80 4.28e-01 0.051200 7.35e-01
Recruitment of mitotic centrosome proteins and complexes 80 4.28e-01 0.051200 7.35e-01
Mitochondrial calcium ion transport 22 6.80e-01 0.050900 8.87e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 5.08e-01 0.050700 7.89e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 5.08e-01 0.050700 7.89e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 5.08e-01 0.050700 7.89e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 5.08e-01 0.050700 7.89e-01
Signaling by NOTCH1 in Cancer 57 5.08e-01 0.050700 7.89e-01
Semaphorin interactions 63 4.87e-01 -0.050700 7.75e-01
SUMO E3 ligases SUMOylate target proteins 162 2.69e-01 -0.050400 6.38e-01
Homologous DNA Pairing and Strand Exchange 41 5.77e-01 0.050400 8.37e-01
Signaling by FGFR in disease 53 5.26e-01 0.050300 8.01e-01
Signaling by NTRKs 127 3.32e-01 -0.049900 6.85e-01
Nuclear events stimulated by ALK signaling in cancer 18 7.15e-01 -0.049800 9.08e-01
HIV elongation arrest and recovery 32 6.27e-01 0.049600 8.62e-01
Pausing and recovery of HIV elongation 32 6.27e-01 0.049600 8.62e-01
MicroRNA (miRNA) biogenesis 24 6.74e-01 0.049600 8.87e-01
RHO GTPases Activate Formins 127 3.35e-01 0.049500 6.87e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 3.94e-01 -0.049400 7.20e-01
Regulation of TP53 Activity 150 2.98e-01 -0.049300 6.51e-01
PI3K/AKT Signaling in Cancer 85 4.33e-01 -0.049200 7.39e-01
Signaling by MET 75 4.62e-01 -0.049200 7.62e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.85e-01 0.048800 8.88e-01
Switching of origins to a post-replicative state 89 4.29e-01 0.048600 7.35e-01
HIV Infection 223 2.13e-01 -0.048500 5.75e-01
Potassium Channels 57 5.27e-01 0.048400 8.01e-01
HCMV Infection 100 4.03e-01 0.048400 7.30e-01
Nucleotide salvage 21 7.01e-01 -0.048400 9.00e-01
Neurotransmitter release cycle 41 5.92e-01 0.048300 8.50e-01
G beta:gamma signalling through CDC42 16 7.38e-01 -0.048300 9.14e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 6.18e-01 -0.048100 8.60e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 7.73e-01 0.048000 9.29e-01
Degradation of beta-catenin by the destruction complex 83 4.50e-01 0.047900 7.53e-01
Cytochrome P450 - arranged by substrate type 34 6.30e-01 -0.047700 8.65e-01
Downstream signaling events of B Cell Receptor (BCR) 79 4.65e-01 0.047600 7.65e-01
Vif-mediated degradation of APOBEC3G 52 5.53e-01 0.047500 8.19e-01
Association of TriC/CCT with target proteins during biosynthesis 35 6.27e-01 0.047400 8.62e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 6.19e-01 0.047300 8.60e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 7.77e-01 -0.047100 9.30e-01
ALK mutants bind TKIs 11 7.88e-01 0.046900 9.32e-01
Signaling by EGFR in Cancer 24 6.91e-01 -0.046900 8.91e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 5.67e-01 0.046800 8.30e-01
Diseases of programmed cell death 48 5.75e-01 -0.046800 8.37e-01
RAB GEFs exchange GTP for GDP on RABs 87 4.53e-01 -0.046500 7.53e-01
FGFR2 alternative splicing 24 6.93e-01 0.046500 8.93e-01
Post-translational protein modification 1207 7.03e-03 -0.046400 6.82e-02
PPARA activates gene expression 105 4.11e-01 -0.046400 7.33e-01
Heme signaling 44 5.95e-01 -0.046400 8.50e-01
Gap junction trafficking and regulation 34 6.40e-01 -0.046300 8.70e-01
Signaling by WNT in cancer 28 6.72e-01 0.046200 8.87e-01
GABA synthesis, release, reuptake and degradation 15 7.57e-01 -0.046200 9.19e-01
MET activates PTK2 signaling 30 6.62e-01 -0.046200 8.82e-01
DNA Replication 130 3.64e-01 0.046100 7.00e-01
Uptake and function of anthrax toxins 11 7.91e-01 -0.046100 9.32e-01
tRNA processing in the nucleus 59 5.42e-01 -0.045900 8.11e-01
Ribavirin ADME 10 8.02e-01 -0.045900 9.36e-01
Regulation of RUNX3 expression and activity 55 5.57e-01 -0.045800 8.21e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 40 6.22e-01 0.045000 8.60e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 7.35e-01 0.044900 9.14e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 7.35e-01 0.044900 9.14e-01
Transmission across Chemical Synapses 198 2.77e-01 0.044900 6.42e-01
Regulation of CDH11 Expression and Function 27 6.88e-01 -0.044700 8.88e-01
NCAM signaling for neurite out-growth 53 5.75e-01 -0.044600 8.37e-01
Adherens junctions interactions 45 6.06e-01 0.044500 8.54e-01
ER Quality Control Compartment (ERQC) 21 7.26e-01 -0.044300 9.08e-01
Phase II - Conjugation of compounds 69 5.28e-01 0.044000 8.01e-01
Tie2 Signaling 15 7.68e-01 -0.043900 9.25e-01
HCMV Early Events 77 5.06e-01 0.043900 7.89e-01
Neurotransmitter receptors and postsynaptic signal transmission 147 3.60e-01 0.043700 7.00e-01
Regulated Necrosis 53 5.82e-01 -0.043700 8.40e-01
DNA Damage Recognition in GG-NER 38 6.41e-01 0.043700 8.70e-01
Signaling by FGFR1 40 6.34e-01 0.043600 8.68e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 7.19e-01 -0.043400 9.08e-01
RHOF GTPase cycle 39 6.40e-01 -0.043400 8.70e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 5.08e-01 0.043300 7.89e-01
Gene Silencing by RNA 79 5.08e-01 0.043100 7.89e-01
Nuclear Receptor transcription pathway 39 6.42e-01 0.043000 8.70e-01
Signaling by ALK fusions and activated point mutants 54 5.84e-01 -0.043000 8.41e-01
Signaling by ALK in cancer 54 5.84e-01 -0.043000 8.41e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 7.28e-01 -0.042800 9.11e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 6.77e-01 0.042500 8.87e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 7.76e-01 -0.042400 9.30e-01
Mitochondrial protein import 63 5.61e-01 0.042300 8.24e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 5.03e-01 0.042300 7.89e-01
Signaling by WNT 245 2.57e-01 0.042100 6.22e-01
FLT3 Signaling 37 6.58e-01 -0.042000 8.80e-01
Activation of BH3-only proteins 29 6.96e-01 -0.041900 8.95e-01
Transport of vitamins, nucleosides, and related molecules 31 6.87e-01 -0.041800 8.88e-01
Signaling by the B Cell Receptor (BCR) 113 4.47e-01 -0.041400 7.53e-01
Postmitotic nuclear pore complex (NPC) reformation 27 7.10e-01 -0.041300 9.07e-01
IGF1R signaling cascade 39 6.56e-01 0.041200 8.80e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 7.18e-01 -0.040900 9.08e-01
Formation of apoptosome 11 8.16e-01 -0.040600 9.45e-01
Glutamate and glutamine metabolism 11 8.16e-01 -0.040600 9.45e-01
Regulation of the apoptosome activity 11 8.16e-01 -0.040600 9.45e-01
Orc1 removal from chromatin 68 5.65e-01 0.040300 8.29e-01
G2/M Transition 186 3.54e-01 0.039500 6.95e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 4.79e-01 -0.039500 7.71e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 4.79e-01 -0.039500 7.71e-01
Acyl chain remodelling of PI 11 8.21e-01 0.039400 9.45e-01
RAB geranylgeranylation 57 6.08e-01 0.039300 8.54e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 7.92e-01 0.039300 9.32e-01
Interleukin-1 signaling 110 4.78e-01 -0.039200 7.71e-01
MAP2K and MAPK activation 36 6.85e-01 -0.039100 8.88e-01
ERKs are inactivated 13 8.08e-01 -0.038900 9.42e-01
Cristae formation 29 7.17e-01 0.038900 9.08e-01
Processing of DNA double-strand break ends 61 6.01e-01 0.038800 8.51e-01
PTEN Regulation 137 4.34e-01 0.038700 7.39e-01
Myogenesis 22 7.54e-01 0.038600 9.19e-01
Interleukin-1 family signaling 138 4.35e-01 -0.038600 7.39e-01
SUMOylation 168 3.90e-01 -0.038500 7.16e-01
Netrin-1 signaling 42 6.67e-01 0.038400 8.85e-01
Regulation of HSF1-mediated heat shock response 78 5.58e-01 0.038400 8.21e-01
Synthesis of very long-chain fatty acyl-CoAs 19 7.73e-01 0.038200 9.29e-01
Transcriptional regulation by RUNX2 115 4.81e-01 -0.038100 7.71e-01
Toll Like Receptor 2 (TLR2) Cascade 109 4.92e-01 -0.038100 7.80e-01
Toll Like Receptor TLR1:TLR2 Cascade 109 4.92e-01 -0.038100 7.80e-01
APC/C:Cdc20 mediated degradation of Securin 66 5.94e-01 0.038000 8.50e-01
Nucleotide Excision Repair 110 4.93e-01 0.037900 7.80e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 6.01e-01 0.037800 8.51e-01
Mitotic Prometaphase 190 3.69e-01 0.037800 7.00e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 8.07e-01 0.037800 9.41e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 7.12e-01 -0.037800 9.07e-01
RIPK1-mediated regulated necrosis 30 7.22e-01 0.037600 9.08e-01
Regulation of necroptotic cell death 30 7.22e-01 0.037600 9.08e-01
Mitochondrial biogenesis 85 5.52e-01 -0.037400 8.18e-01
Presynaptic function of Kainate receptors 17 7.91e-01 -0.037200 9.32e-01
Ubiquitin-dependent degradation of Cyclin D 50 6.51e-01 0.037000 8.77e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 7.86e-01 -0.036900 9.32e-01
Activation of gene expression by SREBF (SREBP) 42 6.80e-01 0.036800 8.87e-01
SUMOylation of intracellular receptors 27 7.43e-01 0.036500 9.17e-01
Acetylcholine Neurotransmitter Release Cycle 13 8.22e-01 -0.036100 9.45e-01
Telomere Extension By Telomerase 21 7.77e-01 0.035700 9.30e-01
Keratan sulfate biosynthesis 26 7.53e-01 0.035700 9.19e-01
Transcriptional regulation of white adipocyte differentiation 82 5.78e-01 -0.035600 8.37e-01
Glycogen breakdown (glycogenolysis) 14 8.18e-01 -0.035500 9.45e-01
COPI-mediated anterograde transport 92 5.56e-01 -0.035500 8.20e-01
Extension of Telomeres 49 6.68e-01 0.035400 8.85e-01
Processing of Capped Intron-Containing Pre-mRNA 278 3.11e-01 0.035400 6.65e-01
ADORA2B mediated anti-inflammatory cytokines production 36 7.16e-01 -0.035100 9.08e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 8.48e-01 0.035100 9.64e-01
RHOB GTPase cycle 66 6.23e-01 0.035100 8.60e-01
Circadian Clock 66 6.24e-01 0.034900 8.60e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 8.10e-01 -0.034700 9.43e-01
Ub-specific processing proteases 157 4.54e-01 0.034700 7.53e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 7.65e-01 -0.034600 9.25e-01
Reduction of cytosolic Ca++ levels 10 8.50e-01 0.034600 9.65e-01
S Phase 159 4.52e-01 0.034600 7.53e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 7.80e-01 -0.034400 9.32e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 8.51e-01 -0.034400 9.65e-01
HDR through Single Strand Annealing (SSA) 35 7.25e-01 -0.034300 9.08e-01
Glucagon-type ligand receptors 20 7.90e-01 0.034300 9.32e-01
Endogenous sterols 21 7.86e-01 -0.034200 9.32e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 6.84e-01 0.034000 8.88e-01
RNA Polymerase III Transcription Initiation 36 7.24e-01 0.034000 9.08e-01
Metabolism of water-soluble vitamins and cofactors 110 5.48e-01 -0.033200 8.16e-01
DNA Double-Strand Break Repair 130 5.16e-01 -0.033000 7.94e-01
Degradation of DVL 55 6.74e-01 0.032800 8.87e-01
Class A/1 (Rhodopsin-like receptors) 156 4.80e-01 -0.032800 7.71e-01
Regulation of PTEN stability and activity 67 6.45e-01 0.032600 8.71e-01
Transcriptional regulation by RUNX3 94 5.87e-01 0.032500 8.43e-01
Negative regulation of FLT3 14 8.34e-01 -0.032400 9.55e-01
Late Phase of HIV Life Cycle 132 5.20e-01 0.032400 7.98e-01
Termination of translesion DNA synthesis 31 7.55e-01 0.032400 9.19e-01
Impaired BRCA2 binding to RAD51 33 7.48e-01 0.032300 9.17e-01
G2/M DNA damage checkpoint 58 6.71e-01 0.032300 8.87e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 7.68e-01 0.032200 9.25e-01
RAF activation 34 7.45e-01 -0.032200 9.17e-01
Interleukin-4 and Interleukin-13 signaling 93 5.93e-01 -0.032100 8.50e-01
Tight junction interactions 17 8.19e-01 0.032000 9.45e-01
RAC3 GTPase cycle 87 6.08e-01 -0.031800 8.54e-01
Synthesis of DNA 118 5.52e-01 0.031800 8.18e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 7.49e-01 -0.031800 9.17e-01
AURKA Activation by TPX2 71 6.45e-01 0.031600 8.71e-01
Antigen processing: Ubiquitination & Proteasome degradation 285 3.59e-01 -0.031600 7.00e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 7.85e-01 0.031500 9.32e-01
Mitotic G2-G2/M phases 188 4.59e-01 0.031400 7.59e-01
Norepinephrine Neurotransmitter Release Cycle 15 8.35e-01 -0.031100 9.55e-01
Regulation of CDH11 function 10 8.65e-01 0.030900 9.70e-01
EML4 and NUDC in mitotic spindle formation 104 5.87e-01 0.030900 8.43e-01
Transcriptional regulation of granulopoiesis 35 7.52e-01 0.030800 9.19e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 7.86e-01 0.030700 9.32e-01
Cellular response to hypoxia 72 6.57e-01 0.030300 8.80e-01
KEAP1-NFE2L2 pathway 102 6.00e-01 -0.030000 8.51e-01
Oxidative Stress Induced Senescence 70 6.65e-01 0.029900 8.85e-01
Viral Infection Pathways 668 1.92e-01 0.029700 5.42e-01
Cell-cell junction organization 64 6.82e-01 0.029600 8.88e-01
Processive synthesis on the lagging strand 15 8.44e-01 -0.029400 9.61e-01
Suppression of phagosomal maturation 13 8.54e-01 0.029400 9.66e-01
Disease 1490 6.05e-02 -0.029400 2.99e-01
Syndecan interactions 26 7.96e-01 -0.029300 9.33e-01
Nicotinate metabolism 27 7.96e-01 -0.028800 9.33e-01
Regulation of APC/C activators between G1/S and early anaphase 78 6.66e-01 -0.028300 8.85e-01
Sensory processing of sound 59 7.07e-01 0.028300 9.05e-01
SARS-CoV-2-host interactions 177 5.18e-01 0.028200 7.96e-01
DNA Double Strand Break Response 44 7.47e-01 0.028100 9.17e-01
Cell junction organization 89 6.49e-01 0.027900 8.76e-01
Transcriptional regulation by small RNAs 54 7.26e-01 0.027600 9.08e-01
GLI3 is processed to GLI3R by the proteasome 57 7.19e-01 -0.027600 9.08e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.27e-01 -0.027500 9.50e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 7.30e-01 0.027400 9.12e-01
SCF(Skp2)-mediated degradation of p27/p21 59 7.18e-01 0.027200 9.08e-01
APC/C-mediated degradation of cell cycle proteins 85 6.68e-01 -0.027000 8.85e-01
Regulation of mitotic cell cycle 85 6.68e-01 -0.027000 8.85e-01
Diseases of mitotic cell cycle 38 7.76e-01 0.026700 9.30e-01
M Phase 347 3.94e-01 0.026700 7.20e-01
L1CAM interactions 104 6.41e-01 0.026500 8.70e-01
RHO GTPase cycle 420 3.54e-01 -0.026400 6.95e-01
AKT phosphorylates targets in the cytosol 14 8.66e-01 -0.026100 9.70e-01
Cyclin D associated events in G1 47 7.57e-01 -0.026100 9.19e-01
G1 Phase 47 7.57e-01 -0.026100 9.19e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 71 7.09e-01 0.025600 9.06e-01
Signaling by NOTCH4 81 6.93e-01 0.025300 8.93e-01
Ion homeostasis 46 7.66e-01 -0.025300 9.25e-01
RHOV GTPase cycle 34 7.99e-01 0.025200 9.35e-01
HDR through MMEJ (alt-NHEJ) 12 8.80e-01 -0.025100 9.76e-01
G2/M Checkpoints 127 6.25e-01 0.025100 8.61e-01
Sensory processing of sound by inner hair cells of the cochlea 55 7.47e-01 0.025100 9.17e-01
Platelet Adhesion to exposed collagen 11 8.86e-01 0.024900 9.77e-01
CDK-mediated phosphorylation and removal of Cdc6 70 7.19e-01 0.024900 9.08e-01
Unwinding of DNA 12 8.82e-01 -0.024800 9.76e-01
Defective B3GAT3 causes JDSSDHD 17 8.60e-01 0.024800 9.67e-01
Mitotic Spindle Checkpoint 105 6.63e-01 0.024600 8.83e-01
Regulation of Apoptosis 51 7.65e-01 0.024200 9.25e-01
Diseases associated with glycosaminoglycan metabolism 38 7.98e-01 -0.024000 9.35e-01
eNOS activation 11 8.91e-01 0.023800 9.78e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 43 7.89e-01 0.023600 9.32e-01
RHOJ GTPase cycle 53 7.68e-01 -0.023400 9.25e-01
Pre-NOTCH Expression and Processing 56 7.62e-01 -0.023400 9.24e-01
Cell Cycle Checkpoints 243 5.32e-01 0.023300 8.03e-01
Oncogene Induced Senescence 33 8.17e-01 -0.023200 9.45e-01
Regulation of RAS by GAPs 65 7.46e-01 0.023200 9.17e-01
Negative regulation of NOTCH4 signaling 54 7.69e-01 0.023100 9.25e-01
Insulin receptor signalling cascade 40 8.01e-01 0.023000 9.36e-01
Leading Strand Synthesis 14 8.82e-01 0.023000 9.76e-01
Polymerase switching 14 8.82e-01 0.023000 9.76e-01
rRNA processing in the mitochondrion 10 9.01e-01 0.022700 9.78e-01
Hedgehog ‘on’ state 82 7.23e-01 -0.022700 9.08e-01
Mitotic G1 phase and G1/S transition 145 6.41e-01 -0.022400 8.70e-01
Muscle contraction 161 6.24e-01 -0.022400 8.60e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 73 7.41e-01 0.022400 9.16e-01
Somitogenesis 50 7.85e-01 -0.022300 9.32e-01
IRS-mediated signalling 35 8.20e-01 0.022200 9.45e-01
Asymmetric localization of PCP proteins 62 7.64e-01 -0.022100 9.24e-01
Regulation of TP53 Degradation 35 8.21e-01 -0.022100 9.45e-01
MAPK family signaling cascades 281 5.26e-01 0.022000 8.01e-01
ERK/MAPK targets 22 8.59e-01 0.021900 9.67e-01
SUMOylation of DNA damage response and repair proteins 77 7.41e-01 0.021800 9.16e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 7.92e-01 0.021800 9.32e-01
RHO GTPase Effectors 247 5.58e-01 0.021700 8.21e-01
p75NTR recruits signalling complexes 13 8.93e-01 0.021600 9.78e-01
Aflatoxin activation and detoxification 12 8.99e-01 0.021300 9.78e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 8.83e-01 -0.021200 9.76e-01
Phosphorylation of the APC/C 20 8.70e-01 -0.021200 9.72e-01
Nucleotide-like (purinergic) receptors 15 8.87e-01 0.021200 9.77e-01
CASP8 activity is inhibited 10 9.08e-01 -0.021200 9.78e-01
Dimerization of procaspase-8 10 9.08e-01 -0.021200 9.78e-01
Regulation by c-FLIP 10 9.08e-01 -0.021200 9.78e-01
Degradation of GLI1 by the proteasome 57 7.83e-01 -0.021100 9.32e-01
MyD88 cascade initiated on plasma membrane 94 7.26e-01 -0.021000 9.08e-01
Toll Like Receptor 10 (TLR10) Cascade 94 7.26e-01 -0.021000 9.08e-01
Toll Like Receptor 5 (TLR5) Cascade 94 7.26e-01 -0.021000 9.08e-01
IKK complex recruitment mediated by RIP1 23 8.62e-01 0.020900 9.69e-01
NIK–>noncanonical NF-kB signaling 57 7.86e-01 -0.020800 9.32e-01
Integration of energy metabolism 88 7.36e-01 -0.020800 9.14e-01
Activation of SMO 16 8.86e-01 0.020800 9.77e-01
Formation of paraxial mesoderm 62 7.77e-01 -0.020800 9.30e-01
Protein-protein interactions at synapses 69 7.66e-01 -0.020700 9.25e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 8.53e-01 0.020600 9.66e-01
Dectin-1 mediated noncanonical NF-kB signaling 58 7.88e-01 -0.020500 9.32e-01
The citric acid (TCA) cycle and respiratory electron transport 160 6.60e-01 0.020200 8.81e-01
Glyoxylate metabolism and glycine degradation 23 8.68e-01 0.020000 9.71e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 7.49e-01 0.019900 9.17e-01
p130Cas linkage to MAPK signaling for integrins 12 9.05e-01 -0.019800 9.78e-01
Regulation of insulin secretion 61 7.90e-01 -0.019700 9.32e-01
Metabolism of proteins 1653 1.89e-01 0.019600 5.41e-01
Regulation of beta-cell development 20 8.80e-01 -0.019600 9.76e-01
Homology Directed Repair 101 7.35e-01 -0.019500 9.14e-01
Signaling by Non-Receptor Tyrosine Kinases 51 8.12e-01 0.019300 9.43e-01
Signaling by PTK6 51 8.12e-01 0.019300 9.43e-01
Cardiac conduction 96 7.45e-01 0.019300 9.17e-01
Metabolism 1756 1.85e-01 -0.019200 5.41e-01
Hh mutants are degraded by ERAD 53 8.09e-01 -0.019200 9.42e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 9.01e-01 -0.019100 9.78e-01
Platelet homeostasis 72 7.81e-01 -0.019000 9.32e-01
Condensation of Prophase Chromosomes 20 8.84e-01 -0.018900 9.76e-01
G beta:gamma signalling through BTK 14 9.04e-01 -0.018700 9.78e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 9.15e-01 -0.018700 9.82e-01
Deadenylation of mRNA 22 8.80e-01 -0.018600 9.76e-01
MTOR signalling 40 8.44e-01 -0.018000 9.61e-01
Regulation of TP53 Expression and Degradation 36 8.52e-01 -0.018000 9.65e-01
Protein localization 155 7.03e-01 -0.017800 9.01e-01
Intracellular signaling by second messengers 280 6.20e-01 -0.017300 8.60e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 9.02e-01 -0.017200 9.78e-01
Metabolism of porphyrins 21 8.91e-01 0.017200 9.78e-01
Generic Transcription Pathway 1092 3.42e-01 0.017200 6.87e-01
Signaling by NOTCH1 72 8.02e-01 0.017100 9.36e-01
Metabolism of nucleotides 81 7.94e-01 -0.016800 9.33e-01
Cell-Cell communication 120 7.54e-01 0.016500 9.19e-01
RNA Polymerase II Transcription 1210 3.37e-01 0.016500 6.87e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 9.07e-01 0.016300 9.78e-01
Defective CFTR causes cystic fibrosis 58 8.32e-01 -0.016100 9.53e-01
Interleukin-7 signaling 19 9.04e-01 0.016100 9.78e-01
DNA strand elongation 32 8.79e-01 -0.015500 9.76e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.29e-01 0.015500 9.83e-01
Dual Incision in GG-NER 41 8.65e-01 0.015300 9.70e-01
MET receptor recycling 10 9.33e-01 0.015300 9.83e-01
RHOG GTPase cycle 71 8.25e-01 0.015200 9.48e-01
RHOH GTPase cycle 33 8.82e-01 0.014900 9.76e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 8.60e-01 0.014600 9.67e-01
p53-Independent DNA Damage Response 49 8.60e-01 0.014600 9.67e-01
p53-Independent G1/S DNA damage checkpoint 49 8.60e-01 0.014600 9.67e-01
Signaling by NOTCH 179 7.37e-01 -0.014600 9.14e-01
Degradation of GLI2 by the proteasome 57 8.51e-01 -0.014400 9.65e-01
FGFR1 mutant receptor activation 25 9.01e-01 0.014300 9.78e-01
Neuronal System 282 6.83e-01 0.014100 8.88e-01
Signal Transduction 2081 3.01e-01 -0.014000 6.55e-01
Fatty acyl-CoA biosynthesis 31 8.94e-01 -0.013900 9.78e-01
APC truncation mutants have impaired AXIN binding 14 9.30e-01 0.013600 9.83e-01
AXIN missense mutants destabilize the destruction complex 14 9.30e-01 0.013600 9.83e-01
Signaling by AMER1 mutants 14 9.30e-01 0.013600 9.83e-01
Signaling by APC mutants 14 9.30e-01 0.013600 9.83e-01
Signaling by AXIN mutants 14 9.30e-01 0.013600 9.83e-01
Truncations of AMER1 destabilize the destruction complex 14 9.30e-01 0.013600 9.83e-01
Biological oxidations 141 7.83e-01 0.013500 9.32e-01
Fatty acid metabolism 142 7.88e-01 -0.013100 9.32e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 8.50e-01 0.013100 9.65e-01
Cellular Senescence 133 7.95e-01 0.013100 9.33e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 8.92e-01 0.013100 9.78e-01
Interleukin-17 signaling 67 8.54e-01 -0.013000 9.66e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 9.10e-01 0.013000 9.80e-01
Phase I - Functionalization of compounds 67 8.56e-01 0.012900 9.66e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 9.06e-01 -0.012800 9.78e-01
HDACs deacetylate histones 37 8.93e-01 0.012800 9.78e-01
tRNA processing 109 8.18e-01 0.012800 9.45e-01
Signaling by Nuclear Receptors 218 7.46e-01 0.012800 9.17e-01
Defective B4GALT7 causes EDS, progeroid type 17 9.28e-01 0.012600 9.83e-01
SCF-beta-TrCP mediated degradation of Emi1 53 8.74e-01 -0.012600 9.75e-01
Spry regulation of FGF signaling 16 9.32e-01 0.012400 9.83e-01
Regulation of ornithine decarboxylase (ODC) 49 8.82e-01 0.012200 9.76e-01
Signaling by NOTCH2 32 9.05e-01 -0.012200 9.78e-01
Signaling by TGF-beta Receptor Complex 90 8.42e-01 0.012200 9.61e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 88 8.44e-01 0.012100 9.61e-01
Amplification of signal from the kinetochores 88 8.44e-01 0.012100 9.61e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 9.48e-01 0.012000 9.90e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 95 8.40e-01 -0.012000 9.60e-01
HDR through Homologous Recombination (HRR) 65 8.71e-01 -0.011700 9.72e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 9.34e-01 -0.011700 9.83e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 9.34e-01 -0.011700 9.83e-01
Hedgehog ligand biogenesis 60 8.76e-01 -0.011600 9.76e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 74 8.65e-01 0.011500 9.70e-01
activated TAK1 mediates p38 MAPK activation 23 9.25e-01 -0.011300 9.83e-01
Beta-catenin phosphorylation cascade 17 9.36e-01 0.011200 9.84e-01
Transcriptional Regulation by VENTX 39 9.04e-01 -0.011100 9.78e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 8.91e-01 0.011000 9.78e-01
Cyclin A:Cdk2-associated events at S phase entry 83 8.66e-01 -0.010700 9.70e-01
UCH proteinases 85 8.68e-01 -0.010400 9.71e-01
Acyl chain remodelling of PS 15 9.45e-01 0.010400 9.89e-01
HCMV Late Events 60 8.92e-01 -0.010100 9.78e-01
Cytosolic sensors of pathogen-associated DNA 63 8.90e-01 -0.010100 9.78e-01
DARPP-32 events 22 9.35e-01 0.010000 9.84e-01
Synthesis of PIPs at the plasma membrane 51 9.01e-01 -0.010000 9.78e-01
Vpu mediated degradation of CD4 50 9.02e-01 0.010000 9.78e-01
Metabolism of vitamins and cofactors 159 8.29e-01 -0.009940 9.51e-01
SUMOylation of transcription cofactors 44 9.09e-01 -0.009940 9.79e-01
Lagging Strand Synthesis 20 9.39e-01 -0.009910 9.85e-01
Signaling by ERBB2 ECD mutants 16 9.46e-01 -0.009820 9.89e-01
Voltage gated Potassium channels 20 9.41e-01 0.009630 9.85e-01
MAP kinase activation 63 8.95e-01 0.009600 9.78e-01
MET promotes cell motility 40 9.20e-01 -0.009220 9.83e-01
Chromatin modifying enzymes 204 8.22e-01 -0.009160 9.45e-01
Chromatin organization 204 8.22e-01 -0.009160 9.45e-01
PKMTs methylate histone lysines 42 9.18e-01 0.009140 9.83e-01
Signaling by NOTCH3 46 9.15e-01 0.009110 9.82e-01
Gene expression (Transcription) 1369 5.84e-01 0.008900 8.41e-01
Prolonged ERK activation events 14 9.55e-01 -0.008740 9.93e-01
Signaling by ERBB2 47 9.18e-01 0.008660 9.83e-01
Neddylation 227 8.35e-01 0.008060 9.55e-01
RND2 GTPase cycle 37 9.33e-01 0.007990 9.83e-01
Signaling by ERBB2 in Cancer 24 9.47e-01 0.007870 9.90e-01
G1/S Transition 127 8.78e-01 -0.007870 9.76e-01
Diseases of signal transduction by growth factor receptors and second messengers 393 7.91e-01 -0.007810 9.32e-01
Cell Cycle 597 7.48e-01 0.007730 9.17e-01
Regulation of TP53 Activity through Phosphorylation 86 9.02e-01 -0.007660 9.78e-01
NF-kB is activated and signals survival 13 9.62e-01 0.007660 9.98e-01
Infectious disease 844 7.09e-01 -0.007600 9.06e-01
Stabilization of p53 54 9.25e-01 0.007440 9.83e-01
p53-Dependent G1 DNA Damage Response 62 9.21e-01 -0.007320 9.83e-01
p53-Dependent G1/S DNA damage checkpoint 62 9.21e-01 -0.007320 9.83e-01
Termination of O-glycan biosynthesis 14 9.62e-01 -0.007270 9.98e-01
Transcriptional Regulation by MECP2 52 9.30e-01 -0.007020 9.83e-01
p75NTR signals via NF-kB 16 9.62e-01 0.006870 9.98e-01
Signaling by NTRK1 (TRKA) 110 9.02e-01 -0.006800 9.78e-01
Signaling by ERBB2 KD Mutants 23 9.55e-01 -0.006780 9.93e-01
Beta-catenin independent WNT signaling 135 8.94e-01 0.006630 9.78e-01
AKT phosphorylates targets in the nucleus 10 9.71e-01 0.006560 9.99e-01
Prostacyclin signalling through prostacyclin receptor 15 9.66e-01 -0.006420 9.99e-01
FOXO-mediated transcription of cell death genes 15 9.67e-01 -0.006120 9.99e-01
Regulation of Expression and Function of Type II Classical Cadherins 29 9.55e-01 0.006110 9.93e-01
Regulation of Homotypic Cell-Cell Adhesion 29 9.55e-01 0.006110 9.93e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.62e-01 0.006110 9.98e-01
Serotonin Neurotransmitter Release Cycle 17 9.65e-01 0.006100 9.99e-01
Extra-nuclear estrogen signaling 69 9.32e-01 0.005950 9.83e-01
G1/S DNA Damage Checkpoints 63 9.36e-01 -0.005860 9.84e-01
Glycogen storage diseases 14 9.70e-01 -0.005710 9.99e-01
SUMOylation of DNA methylation proteins 16 9.70e-01 0.005450 9.99e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 618 8.21e-01 -0.005340 9.45e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 9.77e-01 -0.005200 9.99e-01
HIV Life Cycle 145 9.14e-01 0.005170 9.82e-01
Downstream TCR signaling 85 9.36e-01 -0.005010 9.84e-01
Epigenetic regulation of gene expression 134 9.23e-01 0.004840 9.83e-01
Transcriptional Regulation by TP53 341 8.79e-01 -0.004800 9.76e-01
Signaling by Hedgehog 139 9.24e-01 0.004700 9.83e-01
Inactivation of CSF3 (G-CSF) signaling 24 9.69e-01 -0.004620 9.99e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 9.49e-01 -0.004370 9.90e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 9.72e-01 0.004340 9.99e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.73e-01 0.004320 9.99e-01
Degradation of AXIN 53 9.64e-01 0.003620 9.99e-01
RAF/MAP kinase cascade 240 9.24e-01 -0.003580 9.83e-01
Removal of the Flap Intermediate 14 9.82e-01 -0.003540 9.99e-01
Common Pathway of Fibrin Clot Formation 11 9.84e-01 0.003460 9.99e-01
Nicotinamide salvaging 16 9.81e-01 -0.003440 9.99e-01
MAPK3 (ERK1) activation 10 9.86e-01 -0.003310 9.99e-01
GPCR ligand binding 221 9.37e-01 -0.003070 9.84e-01
Metabolism of polyamines 57 9.69e-01 0.002970 9.99e-01
Activation of NF-kappaB in B cells 65 9.67e-01 -0.002950 9.99e-01
Cell Cycle, Mitotic 486 9.14e-01 0.002870 9.82e-01
PIP3 activates AKT signaling 244 9.40e-01 0.002820 9.85e-01
Glutamate Neurotransmitter Release Cycle 22 9.82e-01 0.002790 9.99e-01
PI3K Cascade 31 9.79e-01 0.002790 9.99e-01
Activated NTRK2 signals through FRS2 and FRS3 10 9.88e-01 0.002780 9.99e-01
RUNX3 regulates NOTCH signaling 14 9.86e-01 0.002740 9.99e-01
Nonhomologous End-Joining (NHEJ) 35 9.80e-01 0.002490 9.99e-01
Signaling by Rho GTPases 603 9.18e-01 -0.002470 9.83e-01
Metabolism of steroids 122 9.66e-01 0.002230 9.99e-01
DNA Repair 281 9.49e-01 -0.002210 9.90e-01
Metabolism of non-coding RNA 53 9.79e-01 0.002090 9.99e-01
snRNP Assembly 53 9.79e-01 0.002090 9.99e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 9.85e-01 -0.002020 9.99e-01
Metabolism of cofactors 18 9.89e-01 0.001790 9.99e-01
Class I peroxisomal membrane protein import 19 9.90e-01 0.001720 9.99e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 9.89e-01 -0.001680 9.99e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 9.89e-01 -0.001680 9.99e-01
Nuclear events mediated by NFE2L2 77 9.80e-01 0.001660 9.99e-01
Activation of ATR in response to replication stress 33 9.87e-01 -0.001640 9.99e-01
Apoptosis 164 9.73e-01 0.001540 9.99e-01
Lysosphingolipid and LPA receptors 10 9.93e-01 -0.001500 9.99e-01
E2F mediated regulation of DNA replication 22 9.91e-01 -0.001410 9.99e-01
Phase 2 - plateau phase 10 9.94e-01 -0.001400 9.99e-01
Deubiquitination 229 9.71e-01 0.001400 9.99e-01
Hh mutants abrogate ligand secretion 55 9.87e-01 -0.001290 9.99e-01
Cyclin E associated events during G1/S transition 81 9.86e-01 0.001110 9.99e-01
Deadenylation-dependent mRNA decay 50 9.89e-01 0.001110 9.99e-01
MAPK1/MAPK3 signaling 246 9.82e-01 0.000826 9.99e-01
Regulation of RUNX2 expression and activity 70 9.91e-01 -0.000791 9.99e-01
ECM proteoglycans 65 9.92e-01 0.000724 9.99e-01
Synthesis of IP3 and IP4 in the cytosol 24 9.96e-01 -0.000622 9.99e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 9.96e-01 0.000586 9.99e-01
Purine salvage 12 9.97e-01 0.000530 9.99e-01
Regulation of innate immune responses to cytosolic DNA 14 9.98e-01 -0.000422 9.99e-01
RHOC GTPase cycle 70 9.95e-01 -0.000393 9.99e-01
Peptide ligand-binding receptors 89 9.95e-01 0.000387 9.99e-01
Kinesins 49 9.98e-01 0.000214 9.99e-01
Programmed Cell Death 192 9.96e-01 -0.000212 9.99e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 9.99e-01 -0.000174 9.99e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 9.99e-01 0.000121 9.99e-01


Detailed Gene set reports



SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1107
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 5.31e-15
s.dist 0.753
p.adjustANOVA 2.92e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
EEF1A1 7895
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
HNRNPA1 6806

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
EEF1A1 7895
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
HNRNPA1 6806
RPS24 6802
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPS29 6283
RPS28 6238
RPS16 6124
RPS12 6075
RPS9 5735
RPS21 5653
RPS18 5530
RPS4X 5267
RPS2 4768
RPS4Y1 1782
RPS26 -1698


Peptide chain elongation

Peptide chain elongation
859
set Peptide chain elongation
setSize 87
pANOVA 3.14e-32
s.dist 0.732
p.adjustANOVA 1.16e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
EEF1A1 7895
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
EEF1A1 7895
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
RPS2 4768
RPLP0 4642
RPL39L 3498
RPL26L1 3493
RPL28 2504
EEF2 2348
RPL9 2110
RPS4Y1 1782
RPS26 -1698
RPL22L1 -2079


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
373
set Eukaryotic Translation Elongation
setSize 92
pANOVA 3.56e-33
s.dist 0.723
p.adjustANOVA 2.7e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
EEF1B2 8168
RPS14 8115
RPL18A 7960
RPL34 7903
EEF1A1 7895
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
EEF1D 7618
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EEF1B2 8168
RPS14 8115
RPL18A 7960
RPL34 7903
EEF1A1 7895
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
EEF1D 7618
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
EEF1A1P5 6945
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
EEF1G 6286
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
RPS2 4768
RPLP0 4642
RPL39L 3498
RPL26L1 3493
RPL28 2504
EEF2 2348
RPL9 2110
RPS4Y1 1782
RPS26 -1698
RPL22L1 -2079
EEF1A2 -4965


Classical antibody-mediated complement activation

Classical antibody-mediated complement activation
202
set Classical antibody-mediated complement activation
setSize 13
pANOVA 7.28e-06
s.dist -0.718
p.adjustANOVA 0.000208



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
IGHG2 -6973
IGHG1 -6890
C1QC -6479
C1R -5803
C1QA -5746
C1QB -5638
IGHG3 -4982
C1S -3589
IGKC -1151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
IGHG2 -6973
IGHG1 -6890
C1QC -6479
C1R -5803
C1QA -5746
C1QB -5638
IGHG3 -4982
C1S -3589
IGKC -1151


Viral mRNA Translation

Viral mRNA Translation
1435
set Viral mRNA Translation
setSize 87
pANOVA 5.89e-31
s.dist 0.717
p.adjustANOVA 1.46e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
RPS2 4768
RPLP0 4642
RPL39L 3498
RPL26L1 3493
GRSF1 3175
RPL28 2504
RPL9 2110
RPS4Y1 1782
RPS26 -1698
RPL22L1 -2079
DNAJC3 -4428


Selenocysteine synthesis

Selenocysteine synthesis
1153
set Selenocysteine synthesis
setSize 91
pANOVA 1.02e-30
s.dist 0.698
p.adjustANOVA 2.15e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
RPS2 4768
RPLP0 4642
EEFSEC 4290
SARS1 3834
RPL39L 3498
RPL26L1 3493
PSTK 2532
RPL28 2504
RPL9 2110
RPS4Y1 1782
SEPSECS 923
SECISBP2 -758
RPS26 -1698
RPL22L1 -2079
SEPHS2 -2160


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
418
set Formation of a pool of free 40S subunits
setSize 99
pANOVA 3.64e-33
s.dist 0.697
p.adjustANOVA 2.7e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
EIF3H 7291
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
EIF3L 6741
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
EIF3I 6339
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
EIF3G 5826
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
EIF3M 5460
RPL36AL 5427
RPL36A 5413
RPS4X 5267
EIF1AX 5062
RPS2 4768
RPLP0 4642
EIF3D 4594
EIF3C 4357
EIF3A 3808
RPL39L 3498
RPL26L1 3493
RPL28 2504
RPL9 2110
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF3K -171
RPS26 -1698
RPL22L1 -2079
EIF3B -4075


Eukaryotic Translation Termination

Eukaryotic Translation Termination
375
set Eukaryotic Translation Termination
setSize 91
pANOVA 1e-28
s.dist 0.674
p.adjustANOVA 1.48e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
TRMT112 4781
RPS2 4768
RPLP0 4642
RPL39L 3498
RPL26L1 3493
RPL28 2504
RPL9 2110
RPS4Y1 1782
ETF1 1473
RPS26 -1698
GSPT2 -1934
RPL22L1 -2079
GSPT1 -3107
APEH -3547
N6AMT1 -8009


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
789
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 93
pANOVA 1.44e-28
s.dist 0.664
p.adjustANOVA 1.94e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
RPS2 4768
RPLP0 4642
PABPC1 3810
RPL39L 3498
RPL26L1 3493
RPL28 2504
RPL9 2110
NCBP2 1938
RPS4Y1 1782
ETF1 1473
NCBP1 254
RPS26 -1698
GSPT2 -1934
RPL22L1 -2079
GSPT1 -3107
UPF1 -3377
EIF4G1 -5229


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
627
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 109
pANOVA 2.87e-32
s.dist 0.655
p.adjustANOVA 1.16e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
EIF3H 7291
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
EIF3L 6741
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
EIF3I 6339
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
EIF2S2 6188
RPL3 6179
RPLP1 6158
EIF4B 6154
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
EIF3G 5826
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
EIF3M 5460
RPL36AL 5427
RPL36A 5413
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
RPS2 4768
RPLP0 4642
EIF3D 4594
EIF3C 4357
PABPC1 3810
EIF3A 3808
RPL39L 3498
RPL26L1 3493
RPL28 2504
RPL9 2110
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
RPL22L1 -2079
EIF3B -4075
EIF4G1 -5229


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
426
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 1.17e-15
s.dist 0.648
p.adjustANOVA 6.66e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
RPS24 6802
EIF3L 6741
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
EIF3I 6339
RPS29 6283
RPS28 6238
EIF2S2 6188
RPS16 6124
RPS12 6075
EIF3G 5826
RPS9 5735
RPS21 5653
RPS18 5530
EIF3M 5460
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
RPS2 4768
EIF3D 4594
EIF3C 4357
EIF3A 3808
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF3K -171
EIF2S3 -1224
RPS26 -1698
EIF3B -4075


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1091
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 99
pANOVA 1.61e-28
s.dist 0.644
p.adjustANOVA 1.99e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATF3 8618
CEBPG 8422
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF3 8618
CEBPG 8422
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
EIF2S2 6188
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
EIF2S1 5338
RPS4X 5267
RPS2 4768
RPLP0 4642
RPL39L 3498
RPL26L1 3493
ATF4 3224
RPL28 2504
RPL9 2110
RPS4Y1 1782
EIF2AK4 1141
IMPACT -699
ATF2 -1057
CEBPB -1165
EIF2S3 -1224
RPS26 -1698
RPL22L1 -2079
ASNS -2422
DDIT3 -2701
TRIB3 -6269
GCN1 -7265


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
464
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 110
pANOVA 2.01e-31
s.dist 0.643
p.adjustANOVA 5.95e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
EIF3H 7291
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
EIF3L 6741
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
EIF3I 6339
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
EIF2S2 6188
RPL3 6179
RPLP1 6158
EIF4B 6154
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
EIF3G 5826
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
EIF3M 5460
RPL36AL 5427
RPL36A 5413
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
RPS2 4768
RPLP0 4642
EIF3D 4594
EIF3C 4357
EIF3A 3808
RPL39L 3498
RPL26L1 3493
EIF5B 3048
RPL28 2504
RPL9 2110
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
RPL22L1 -2079
EIF3B -4075
EIF5 -4979
EIF4G1 -5229


FCGR activation

FCGR activation
385
set FCGR activation
setSize 20
pANOVA 7.34e-07
s.dist -0.639
p.adjustANOVA 2.59e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
FCGR2A -8279
FCGR1A -8113
FCGR3A -7985
IGLC2 -7870
HCK -7733
SYK -7142
IGHG2 -6973
FGR -6972
IGHG1 -6890
CD247 -6839
SRC -5305
IGHG3 -4982
LYN -4370
FYN -1654
IGKC -1151
YES1 1029
CD3G 6329

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
FCGR2A -8279
FCGR1A -8113
FCGR3A -7985
IGLC2 -7870
HCK -7733
SYK -7142
IGHG2 -6973
FGR -6972
IGHG1 -6890
CD247 -6839
SRC -5305
IGHG3 -4982
LYN -4370
FYN -1654
IGKC -1151
YES1 1029
CD3G 6329


Creation of C4 and C2 activators

Creation of C4 and C2 activators
230
set Creation of C4 and C2 activators
setSize 16
pANOVA 1.28e-05
s.dist -0.63
p.adjustANOVA 0.000329



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
IGHG2 -6973
IGHG1 -6890
C1QC -6479
MASP2 -5886
C1R -5803
C1QA -5746
C1QB -5638
IGHG3 -4982
C1S -3589
MASP1 -2834
IGKC -1151
FCN1 2327

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
IGHG2 -6973
IGHG1 -6890
C1QC -6479
MASP2 -5886
C1R -5803
C1QA -5746
C1QB -5638
IGHG3 -4982
C1S -3589
MASP1 -2834
IGKC -1151
FCN1 2327


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
154
set Cap-dependent Translation Initiation
setSize 117
pANOVA 1.78e-29
s.dist 0.603
p.adjustANOVA 2.93e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
EIF3H 7291
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
EIF3L 6741
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
EIF3I 6339
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
EIF2S2 6188
RPL3 6179
RPLP1 6158
EIF4B 6154
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
EIF3G 5826
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
EIF3M 5460
RPL36AL 5427
RPL36A 5413
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
EIF2B3 4853
RPS2 4768
RPLP0 4642
EIF3D 4594
EIF3C 4357
PABPC1 3810
EIF3A 3808
EIF2B2 3550
RPL39L 3498
RPL26L1 3493
EIF5B 3048
RPL28 2504
RPL9 2110
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF2B4 -88
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
RPL22L1 -2079
EIF4EBP1 -3119
EIF3B -4075
EIF2B5 -4355
EIF5 -4979
EIF4G1 -5229
EIF2B1 -6523


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
374
set Eukaryotic Translation Initiation
setSize 117
pANOVA 1.78e-29
s.dist 0.603
p.adjustANOVA 2.93e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
EIF4A2 7536
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
EIF3H 7291
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
EIF3L 6741
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
EIF3I 6339
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
EIF2S2 6188
RPL3 6179
RPLP1 6158
EIF4B 6154
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
EIF3G 5826
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
EIF3M 5460
RPL36AL 5427
RPL36A 5413
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
EIF2B3 4853
RPS2 4768
RPLP0 4642
EIF3D 4594
EIF3C 4357
PABPC1 3810
EIF3A 3808
EIF2B2 3550
RPL39L 3498
RPL26L1 3493
EIF5B 3048
RPL28 2504
RPL9 2110
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF2B4 -88
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
RPL22L1 -2079
EIF4EBP1 -3119
EIF3B -4075
EIF2B5 -4355
EIF5 -4979
EIF4G1 -5229
EIF2B1 -6523


SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
1113
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 3.7e-13
s.dist 0.6
p.adjustANOVA 1.66e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
SMN1 7896
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
GEMIN5 7767
RPS15A 7639
RPS27A 7636
RPS5 7614
RPS6 7516
RPS10 7438
RPS13 7341
SNRPD1 7338
RPSA 7336
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
SMN1 7896
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
GEMIN5 7767
RPS15A 7639
RPS27A 7636
RPS5 7614
RPS6 7516
RPS10 7438
RPS13 7341
SNRPD1 7338
RPSA 7336
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
RPS24 6802
SNRPD2 6702
RPS19 6640
GEMIN8 6580
RPS27L 6553
RPS27 6484
RPS25 6393
RPS29 6283
RPS28 6238
RPS16 6124
RPS12 6075
RPS9 5735
RPS21 5653
SNRPE 5596
RPS18 5530
RPS4X 5267
RPS2 4768
SNRPB 4182
GEMIN6 1974
RPS4Y1 1782
SNRPG 38
GEMIN2 -209
SNRPD3 -534
DDX20 -1460
RPS26 -1698
SNRPF -2122
GEMIN4 -3980
GEMIN7 -5468


Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
377
set Expression and translocation of olfactory receptors
setSize 22
pANOVA 1.34e-06
s.dist 0.595
p.adjustANOVA 4.52e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR6C75 8539
OR10H5 8370
OR6Y1 8313
OR2M3 8269
OR5A1 8245
OR2AT4 8150
OR7C1 8112
OR1D2 7908
OR5AN1 7649
OR14J1 7590
OR1I1 7498
OR5AS1 7423
OR4D9 7071
OR10G3 5658
OR52K1 4897
REEP1 4884
OR5A2 3846
OR8A1 2888
OR2A7 -138
EBF1 -1250

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR6C75 8539
OR10H5 8370
OR6Y1 8313
OR2M3 8269
OR5A1 8245
OR2AT4 8150
OR7C1 8112
OR1D2 7908
OR5AN1 7649
OR14J1 7590
OR1I1 7498
OR5AS1 7423
OR4D9 7071
OR10G3 5658
OR52K1 4897
REEP1 4884
OR5A2 3846
OR8A1 2888
OR2A7 -138
EBF1 -1250
LDB1 -2420
OR2I1P -8427


Translation initiation complex formation

Translation initiation complex formation
1385
set Translation initiation complex formation
setSize 58
pANOVA 7.83e-15
s.dist 0.59
p.adjustANOVA 4.15e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
EIF4A2 7536
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
EIF4A2 7536
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
RPS24 6802
EIF3L 6741
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
EIF3I 6339
RPS29 6283
RPS28 6238
EIF2S2 6188
EIF4B 6154
RPS16 6124
RPS12 6075
EIF3G 5826
RPS9 5735
RPS21 5653
RPS18 5530
EIF3M 5460
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
RPS2 4768
EIF3D 4594
EIF3C 4357
PABPC1 3810
EIF3A 3808
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
EIF3B -4075
EIF4G1 -5229


Mucopolysaccharidoses

Mucopolysaccharidoses
726
set Mucopolysaccharidoses
setSize 11
pANOVA 0.000814
s.dist -0.583
p.adjustANOVA 0.0137



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDUA -8562
SGSH -8225
GALNS -8154
NAGLU -7986
GNS -7644
GLB1 -7405
GUSB -4019
HGSNAT -3571
ARSB -2772
IDS 1201
HYAL1 1718

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDUA -8562
SGSH -8225
GALNS -8154
NAGLU -7986
GNS -7644
GLB1 -7405
GUSB -4019
HGSNAT -3571
ARSB -2772
IDS 1201
HYAL1 1718


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
51
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 2.49e-14
s.dist 0.573
p.adjustANOVA 1.27e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
EIF4A2 7536
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
EIF4A2 7536
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
RPS24 6802
EIF3L 6741
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
EIF3I 6339
RPS29 6283
RPS28 6238
EIF2S2 6188
EIF4B 6154
RPS16 6124
RPS12 6075
EIF3G 5826
RPS9 5735
RPS21 5653
RPS18 5530
EIF3M 5460
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
RPS2 4768
EIF3D 4594
EIF3C 4357
PABPC1 3810
EIF3A 3808
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
EIF4EBP1 -3119
EIF3B -4075
EIF4G1 -5229


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1100
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 4.77e-14
s.dist 0.572
p.adjustANOVA 2.36e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
EIF4A2 7536
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3E 8452
RPS14 8115
FAU 7867
RPS7 7855
RPS11 7841
RPS3A 7827
RPS15A 7639
RPS27A 7636
RPS5 7614
EIF4A2 7536
RPS6 7516
RPS10 7438
RPS13 7341
RPSA 7336
EIF3H 7291
RPS23 7279
RPS20 7274
RPS8 7231
RPS17 6977
RPS3 6842
RPS15 6811
RPS24 6802
EIF3L 6741
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
EIF3I 6339
RPS29 6283
RPS28 6238
EIF2S2 6188
EIF4B 6154
RPS16 6124
RPS12 6075
EIF3G 5826
RPS9 5735
RPS21 5653
RPS18 5530
EIF3M 5460
EIF2S1 5338
RPS4X 5267
EIF1AX 5062
RPS2 4768
EIF3D 4594
EIF3C 4357
EIF3A 3808
RPS4Y1 1782
EIF3F 1625
EIF3J 131
EIF4E -1
EIF3K -171
EIF4H -348
EIF2S3 -1224
RPS26 -1698
EIF4A1 -2064
EIF3B -4075
EIF5 -4979
EIF4G1 -5229


Selenoamino acid metabolism

Selenoamino acid metabolism
1152
set Selenoamino acid metabolism
setSize 113
pANOVA 1.1e-25
s.dist 0.57
p.adjustANOVA 1.25e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
NNMT 7703
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
NNMT 7703
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
INMT 7044
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
AHCY 5975
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
KARS1 5213
RPS2 4768
RPLP0 4642
EEFSEC 4290
SARS1 3834
PAPSS2 3667
AIMP2 3610
RPL39L 3498
RPL26L1 3493
PSTK 2532
RPL28 2504
AIMP1 2206
RPL9 2110
TXNRD1 2041
RPS4Y1 1782
DARS1 1745
EEF1E1 1291
EPRS1 1223
CTH 950
SEPSECS 923
GSR 845
SECISBP2 -758
RARS1 -1084
RPS26 -1698
QARS1 -2009
RPL22L1 -2079
SEPHS2 -2160
CBS -3375
PAPSS1 -3844
LARS1 -4554
HNMT -4623
SCLY -5320
IARS1 -5557
MARS1 -6086


Initial triggering of complement

Initial triggering of complement
569
set Initial triggering of complement
setSize 24
pANOVA 1.44e-06
s.dist -0.568
p.adjustANOVA 4.73e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
C4B -7038
IGHG2 -6973
IGHG1 -6890
C1QC -6479
MASP2 -5886
C1R -5803
C1QA -5746
CFB -5644
C1QB -5638
C2 -5388
IGHG3 -4982
CFD -4354
C1S -3589
CFP -2891
MASP1 -2834
C4A -2719

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
C4B -7038
IGHG2 -6973
IGHG1 -6890
C1QC -6479
MASP2 -5886
C1R -5803
C1QA -5746
CFB -5644
C1QB -5638
C2 -5388
IGHG3 -4982
CFD -4354
C1S -3589
CFP -2891
MASP1 -2834
C4A -2719
C3 -1816
IGKC -1151
GZMM -841
FCN1 2327


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
788
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 113
pANOVA 3.45e-24
s.dist 0.552
p.adjustANOVA 3.19e-22



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
PNRC2 6612
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
PPP2R2A 5965
RPL35 5831
RBM8A 5803
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
MAGOH 5248
RPS2 4768
RPLP0 4642
CASC3 4384
UPF2 4344
SMG8 3941
PABPC1 3810
RPL39L 3498
RPL26L1 3493
DCP1A 3001
MAGOHB 2536
RPL28 2504
RPL9 2110
NCBP2 1938
RPS4Y1 1782
ETF1 1473
EIF4A3 376
NCBP1 254
PPP2CA -267
SMG1 -1662
RPS26 -1698
GSPT2 -1934
RPL22L1 -2079
UPF3A -2419
RNPS1 -2524
UPF3B -2837
GSPT1 -3107
UPF1 -3377
PPP2R1A -3397
SMG7 -3892
EIF4G1 -5229
SMG6 -5241
SMG5 -7494
SMG9 -8018


Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
790
set Nonsense-Mediated Decay (NMD)
setSize 113
pANOVA 3.45e-24
s.dist 0.552
p.adjustANOVA 3.19e-22



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
PNRC2 6612
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
PPP2R2A 5965
RPL35 5831
RBM8A 5803
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
MAGOH 5248
RPS2 4768
RPLP0 4642
CASC3 4384
UPF2 4344
SMG8 3941
PABPC1 3810
RPL39L 3498
RPL26L1 3493
DCP1A 3001
MAGOHB 2536
RPL28 2504
RPL9 2110
NCBP2 1938
RPS4Y1 1782
ETF1 1473
EIF4A3 376
NCBP1 254
PPP2CA -267
SMG1 -1662
RPS26 -1698
GSPT2 -1934
RPL22L1 -2079
UPF3A -2419
RNPS1 -2524
UPF3B -2837
GSPT1 -3107
UPF1 -3377
PPP2R1A -3397
SMG7 -3892
EIF4G1 -5229
SMG6 -5241
SMG5 -7494
SMG9 -8018


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1132
set SRP-dependent cotranslational protein targeting to membrane
setSize 110
pANOVA 5.44e-23
s.dist 0.545
p.adjustANOVA 4.74e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
SEC11A 6709
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
RPS2 4768
RPLP0 4642
SRP19 3842
RPL39L 3498
RPL26L1 3493
SEC11C 2984
SSR2 2622
RPL28 2504
SEC61B 2191
RPL9 2110
SRP54 2044
SPCS1 1948
RPS4Y1 1782
SRP14 1769
SRP9 1663
SRP68 1521
SPCS2 521
SEC61G 90
SRP72 66
TRAM1 -381
SSR3 -1124
RPS26 -1698
RPL22L1 -2079
RPN1 -2618
SPCS3 -3327
SRPRB -3381
SSR4 -4034
SSR1 -4223
SRPRA -4424
DDOST -5218
SEC61A2 -7053
RPN2 -7222
SEC61A1 -7977


Scavenging of heme from plasma

Scavenging of heme from plasma
1149
set Scavenging of heme from plasma
setSize 14
pANOVA 0.000659
s.dist -0.526
p.adjustANOVA 0.0114



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
APOL1 -7818
JCHAIN -7064
HP -6427
LRP1 -5611
CD163 -5242
IGHA2 -4762
HPX -1382
IGHA1 -1345
IGKC -1151
HBB 39
HBA1 1971

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
APOL1 -7818
JCHAIN -7064
HP -6427
LRP1 -5611
CD163 -5242
IGHA2 -4762
HPX -1382
IGHA1 -1345
IGKC -1151
HBB 39
HBA1 1971


Gluconeogenesis

Gluconeogenesis
484
set Gluconeogenesis
setSize 28
pANOVA 1.69e-06
s.dist -0.523
p.adjustANOVA 5.33e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC37A2 -8277
SLC37A4 -8156
ENO3 -7774
PCK1 -7638
GPI -7561
FBP1 -7401
ALDOA -6977
PCK2 -6824
PGAM2 -6437
GOT2 -5869
SLC25A12 -5730
PGK1 -5692
SLC25A11 -5563
G6PC3 -5010
PC -4958
ENO1 -4444
SLC25A13 -4301
TPI1 -4271
MDH1 -4174
ENO2 -3984

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC37A2 -8277
SLC37A4 -8156
ENO3 -7774
PCK1 -7638
GPI -7561
FBP1 -7401
ALDOA -6977
PCK2 -6824
PGAM2 -6437
GOT2 -5869
SLC25A12 -5730
PGK1 -5692
SLC25A11 -5563
G6PC3 -5010
PC -4958
ENO1 -4444
SLC25A13 -4301
TPI1 -4271
MDH1 -4174
ENO2 -3984
MDH2 -3577
GAPDH -2810
ALDOC -1910
SLC25A10 -1729
PGAM1 -1600
GOT1 -621
SLC25A1 2621
SLC37A1 4314


Olfactory Signaling Pathway

Olfactory Signaling Pathway
813
set Olfactory Signaling Pathway
setSize 26
pANOVA 5.38e-06
s.dist 0.515
p.adjustANOVA 0.000157



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR6C75 8539
OR10H5 8370
OR6Y1 8313
OR2M3 8269
OR5A1 8245
OR2AT4 8150
OR7C1 8112
OR1D2 7908
OR5AN1 7649
OR14J1 7590
OR1I1 7498
OR5AS1 7423
OR4D9 7071
ANO2 6956
OR10G3 5658
GNAL 5098
OR52K1 4897
REEP1 4884
OR5A2 3846
OR8A1 2888

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR6C75 8539
OR10H5 8370
OR6Y1 8313
OR2M3 8269
OR5A1 8245
OR2AT4 8150
OR7C1 8112
OR1D2 7908
OR5AN1 7649
OR14J1 7590
OR1I1 7498
OR5AS1 7423
OR4D9 7071
ANO2 6956
OR10G3 5658
GNAL 5098
OR52K1 4897
REEP1 4884
OR5A2 3846
OR8A1 2888
OR2A7 -138
EBF1 -1250
LDB1 -2420
GNB1 -2867
ADCY3 -6582
OR2I1P -8427


Trafficking and processing of endosomal TLR

Trafficking and processing of endosomal TLR
1361
set Trafficking and processing of endosomal TLR
setSize 12
pANOVA 0.00205
s.dist -0.514
p.adjustANOVA 0.0244



Top enriched genes

Top 20 genes
GeneID Gene Rank
LGMN -8357
UNC93B1 -8153
TLR8 -8094
CTSB -7112
CTSL -7056
TLR7 -4543
HSP90B1 -3626
TLR9 -3348
TLR3 -2517
CTSS -2175
CTSK 766
CNPY3 917

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LGMN -8357
UNC93B1 -8153
TLR8 -8094
CTSB -7112
CTSL -7056
TLR7 -4543
HSP90B1 -3626
TLR9 -3348
TLR3 -2517
CTSS -2175
CTSK 766
CNPY3 917


Role of LAT2/NTAL/LAB on calcium mobilization

Role of LAT2/NTAL/LAB on calcium mobilization
1101
set Role of LAT2/NTAL/LAB on calcium mobilization
setSize 20
pANOVA 9.59e-05
s.dist -0.504
p.adjustANOVA 0.00209



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGLC1 -8528
IGLC3 -8412
SHC1 -8297
LAT2 -7999
IGLC2 -7870
GRB2 -7705
FCER1G -7448
PIK3R2 -7148
SYK -7142
PDPK1 -6798
GAB2 -5858
LYN -4370
MS4A2 -2608
FYN -1654
PIK3CB -1354
IGKC -1151
SOS1 -828
PIK3CA 1041
FCER1A 3313
PIK3R1 3780

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGLC1 -8528
IGLC3 -8412
SHC1 -8297
LAT2 -7999
IGLC2 -7870
GRB2 -7705
FCER1G -7448
PIK3R2 -7148
SYK -7142
PDPK1 -6798
GAB2 -5858
LYN -4370
MS4A2 -2608
FYN -1654
PIK3CB -1354
IGKC -1151
SOS1 -828
PIK3CA 1041
FCER1A 3313
PIK3R1 3780


Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
760
set Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
setSize 19
pANOVA 0.00016
s.dist -0.5
p.adjustANOVA 0.00321



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2M1 -8265
AP2A1 -7882
AP1S1 -7103
AP2A2 -6946
AP1B1 -6862
PACS1 -6774
CD4 -6660
AP2S1 -6520
CD28 -6042
AP1G1 -5699
B2M -5258
AP2B1 -4237
ATP6V1H -4078
AP1S2 -3988
LCK -2271
ARF1 -1242
CD8B -304
AP1M1 -53
AP1S3 8087

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2M1 -8265
AP2A1 -7882
AP1S1 -7103
AP2A2 -6946
AP1B1 -6862
PACS1 -6774
CD4 -6660
AP2S1 -6520
CD28 -6042
AP1G1 -5699
B2M -5258
AP2B1 -4237
ATP6V1H -4078
AP1S2 -3988
LCK -2271
ARF1 -1242
CD8B -304
AP1M1 -53
AP1S3 8087


SARS-CoV-2 modulates autophagy

SARS-CoV-2 modulates autophagy
1112
set SARS-CoV-2 modulates autophagy
setSize 11
pANOVA 0.0054
s.dist -0.484
p.adjustANOVA 0.0548



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS39 -8536
VPS16 -8258
VPS18 -7229
VPS41 -6291
VPS33B -5050
VPS45 -4909
VPS11 -4569
TUFM -3581
VPS33A -1716
MAP1LC3B 1018
UVRAG 3061

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS39 -8536
VPS16 -8258
VPS18 -7229
VPS41 -6291
VPS33B -5050
VPS45 -4909
VPS11 -4569
TUFM -3581
VPS33A -1716
MAP1LC3B 1018
UVRAG 3061


Transcriptional regulation of pluripotent stem cells

Transcriptional regulation of pluripotent stem cells
1381
set Transcriptional regulation of pluripotent stem cells
setSize 16
pANOVA 0.000897
s.dist 0.48
p.adjustANOVA 0.0143



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF2 8518
SMAD2 7881
KLF4 7853
HIF3A 7663
TSC22D1 7459
SMAD4 6719
EPHA1 6477
EPAS1 5688
GATA6 4628
FOXP1 3990
PBX1 3799
GSC 3721
HHEX 1691
STAT3 -2894
NR6A1 -3412
POU5F1 -3506

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF2 8518
SMAD2 7881
KLF4 7853
HIF3A 7663
TSC22D1 7459
SMAD4 6719
EPHA1 6477
EPAS1 5688
GATA6 4628
FOXP1 3990
PBX1 3799
GSC 3721
HHEX 1691
STAT3 -2894
NR6A1 -3412
POU5F1 -3506


Scavenging by Class A Receptors

Scavenging by Class A Receptors
1148
set Scavenging by Class A Receptors
setSize 16
pANOVA 0.000954
s.dist -0.477
p.adjustANOVA 0.0149



Top enriched genes

Top 20 genes
GeneID Gene Rank
SCARA5 -7167
MARCO -6924
FTL -6137
COL1A1 -5999
MSR1 -5706
APOE -5210
COL1A2 -4914
COLEC12 -4864
HSP90B1 -3626
APOB -3167
MASP1 -2834
FTH1 -2755
COL4A2 -2649
CALR -2533
COL3A1 -1131
COL4A1 -331

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SCARA5 -7167
MARCO -6924
FTL -6137
COL1A1 -5999
MSR1 -5706
APOE -5210
COL1A2 -4914
COLEC12 -4864
HSP90B1 -3626
APOB -3167
MASP1 -2834
FTH1 -2755
COL4A2 -2649
CALR -2533
COL3A1 -1131
COL4A1 -331


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
1445
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 13
pANOVA 0.00345
s.dist -0.468
p.adjustANOVA 0.0394



Top enriched genes

Top 20 genes
GeneID Gene Rank
FZD2 -8502
AP2M1 -8265
AP2A1 -7882
WNT5A -7808
AP2A2 -6946
AP2S1 -6520
CLTC -4933
ROR2 -4830
AP2B1 -4237
FZD5 -2287
ROR1 666
CLTA 1755
CLTB 7171

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FZD2 -8502
AP2M1 -8265
AP2A1 -7882
WNT5A -7808
AP2A2 -6946
AP2S1 -6520
CLTC -4933
ROR2 -4830
AP2B1 -4237
FZD5 -2287
ROR1 666
CLTA 1755
CLTB 7171


ABC transporters in lipid homeostasis

ABC transporters in lipid homeostasis
3
set ABC transporters in lipid homeostasis
setSize 12
pANOVA 0.00506
s.dist -0.467
p.adjustANOVA 0.0529



Top enriched genes

Top 20 genes
GeneID Gene Rank
ABCA7 -8406
ABCD1 -8151
ABCA2 -7643
PEX19 -7563
ABCG1 -6156
ABCA3 -5921
ABCD3 -5860
ABCA5 -4265
ABCA9 -956
PEX3 1515
ABCA6 2000
ABCA10 2944

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCA7 -8406
ABCD1 -8151
ABCA2 -7643
PEX19 -7563
ABCG1 -6156
ABCA3 -5921
ABCD3 -5860
ABCA5 -4265
ABCA9 -956
PEX3 1515
ABCA6 2000
ABCA10 2944


Interleukin-2 signaling

Interleukin-2 signaling
597
set Interleukin-2 signaling
setSize 11
pANOVA 0.00873
s.dist -0.457
p.adjustANOVA 0.0799



Top enriched genes

Top 20 genes
GeneID Gene Rank
JAK3 -8638
SHC1 -8297
PTK2B -7580
SYK -7142
IL2RB -6099
STAT5A -5072
IL2RA -4778
LCK -2271
IL2RG 792
JAK1 937
STAT5B 4737

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JAK3 -8638
SHC1 -8297
PTK2B -7580
SYK -7142
IL2RB -6099
STAT5A -5072
IL2RA -4778
LCK -2271
IL2RG 792
JAK1 937
STAT5B 4737


The role of Nef in HIV-1 replication and disease pathogenesis

The role of Nef in HIV-1 replication and disease pathogenesis
1346
set The role of Nef in HIV-1 replication and disease pathogenesis
setSize 26
pANOVA 6.19e-05
s.dist -0.454
p.adjustANOVA 0.00143



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2M1 -8265
DOCK2 -7984
AP2A1 -7882
HCK -7733
AP1S1 -7103
AP2A2 -6946
AP1B1 -6862
CD247 -6839
PACS1 -6774
CD4 -6660
AP2S1 -6520
CD28 -6042
AP1G1 -5699
B2M -5258
AP2B1 -4237
ATP6V1H -4078
AP1S2 -3988
LCK -2271
FYN -1654
ARF1 -1242

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2M1 -8265
DOCK2 -7984
AP2A1 -7882
HCK -7733
AP1S1 -7103
AP2A2 -6946
AP1B1 -6862
CD247 -6839
PACS1 -6774
CD4 -6660
AP2S1 -6520
CD28 -6042
AP1G1 -5699
B2M -5258
AP2B1 -4237
ATP6V1H -4078
AP1S2 -3988
LCK -2271
FYN -1654
ARF1 -1242
CD8B -304
AP1M1 -53
PAK2 1068
RAC1 1112
ELMO1 2246
AP1S3 8087


Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
564
set Influenza Viral RNA Transcription and Replication
setSize 134
pANOVA 1.51e-19
s.dist 0.452
p.adjustANOVA 1.12e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
IPO5 8428
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
POLR2F 7572
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IPO5 8428
RPS14 8115
RPL18A 7960
RPL34 7903
FAU 7867
RPS7 7855
RPL15 7851
RPS11 7841
RPS3A 7827
RPL5 7702
RPL4 7696
RPS15A 7639
RPS27A 7636
RPL7 7623
RPS5 7614
POLR2F 7572
RPL39 7526
RPL17 7520
RPS6 7516
RPL30 7495
RPS10 7438
RPL29 7371
RPS13 7341
RPSA 7336
RPL31 7281
RPL35A 7280
RPS23 7279
RPS20 7274
RPL22 7262
RPL26 7242
RPS8 7231
RPL7A 7219
RPL41 7187
RPL32 7125
RPL21 7065
RPL6 7045
RPL14 7019
RPL10 7017
RPS17 6977
RPL8 6975
RPL19 6903
RPL37 6857
RPS3 6842
RPL23 6817
RPS15 6811
RPS24 6802
RPL18 6774
RPL13A 6760
RPL37A 6664
RPS19 6640
RPS27L 6553
RPS27 6484
RPS25 6393
RPL36 6383
RPL11 6366
RPL23A 6332
RPLP2 6284
RPS29 6283
RPS28 6238
RPL24 6202
HSP90AA1 6198
RPL3 6179
RPLP1 6158
RPL27 6127
RPS16 6124
RPS12 6075
RPL12 6004
RPL13 5974
RAE1 5844
RPL35 5831
RPS9 5735
RPL10A 5726
UBA52 5692
RPS21 5653
RPL38 5646
POLR2D 5643
POLR2K 5572
RPS18 5530
RPL27A 5467
RPL36AL 5427
RPL36A 5413
RPS4X 5267
POLR2I 5188
RPS2 4768
NUP37 4757
RPLP0 4642
NUP107 4605
NUP155 4538
GTF2F1 4380
POLR2C 3913
NUP54 3884
NUP205 3742
NUP160 3727
RPL39L 3498
RPL26L1 3493
NUP58 3403
NDC1 3347
RANBP2 3263
NUP35 3222
GRSF1 3175
RPL28 2504
RPL9 2110
RPS4Y1 1782
NUP153 939
PARP1 567
POLR2L 466
NUP42 -101
GTF2F2 -112
SEH1L -465
POLR2J -1158
POLR2E -1583
RPS26 -1698
RPL22L1 -2079
POLR2G -2169
NUP214 -2301
NUP133 -2747
POLR2B -3059
NUP85 -3196
NUP50 -3212
NUP98 -3712
NUP88 -3834
DNAJC3 -4428
SEC13 -4999
NUP210 -5318
POLR2H -5669
NUP188 -5957
NUP93 -6292
NUP43 -6920
POLR2A -7176
TPR -7346
NUP62 -7910
AAAS -7942
POM121 -8149
POM121C -8222


TRAF3-dependent IRF activation pathway

TRAF3-dependent IRF activation pathway
1324
set TRAF3-dependent IRF activation pathway
setSize 13
pANOVA 0.0054
s.dist -0.446
p.adjustANOVA 0.0548



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAVS -8022
IRF3 -7699
IKBKE -7453
IRF7 -6569
TRAF3 -6357
EP300 -5086
SIKE1 -4505
RNF135 -4377
TRIM25 -3269
IFIH1 -3003
CREBBP -213
TBK1 2936
TRIM4 3552

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAVS -8022
IRF3 -7699
IKBKE -7453
IRF7 -6569
TRAF3 -6357
EP300 -5086
SIKE1 -4505
RNF135 -4377
TRIM25 -3269
IFIH1 -3003
CREBBP -213
TBK1 2936
TRIM4 3552


Packaging Of Telomere Ends

Packaging Of Telomere Ends
851
set Packaging Of Telomere Ends
setSize 13
pANOVA 0.00656
s.dist 0.435
p.adjustANOVA 0.064



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AJ 6939
H2BC12 6804
H2BC21 6751
TERF2IP 5689
H2BC5 5011
TERF1 4676
H2AZ2 3625
H2AC18 3523
POT1 2505
H2AC6 2326
ACD 695
TERF2 691
TINF2 -334

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AJ 6939
H2BC12 6804
H2BC21 6751
TERF2IP 5689
H2BC5 5011
TERF1 4676
H2AZ2 3625
H2AC18 3523
POT1 2505
H2AC6 2326
ACD 695
TERF2 691
TINF2 -334


Retrograde neurotrophin signalling

Retrograde neurotrophin signalling
1096
set Retrograde neurotrophin signalling
setSize 14
pANOVA 0.00561
s.dist -0.427
p.adjustANOVA 0.0563



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2M1 -8265
AP2A1 -7882
DNM2 -7713
AP2A2 -6946
DNM1 -6559
AP2S1 -6520
SH3GL2 -5051
CLTC -4933
AP2B1 -4237
NGF -1880
NTRK1 -1821
DNAL4 393
CLTA 1755
DNM3 7942

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2M1 -8265
AP2A1 -7882
DNM2 -7713
AP2A2 -6946
DNM1 -6559
AP2S1 -6520
SH3GL2 -5051
CLTC -4933
AP2B1 -4237
NGF -1880
NTRK1 -1821
DNAL4 393
CLTA 1755
DNM3 7942


Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors
115
set Binding and Uptake of Ligands by Scavenger Receptors
setSize 39
pANOVA 4.39e-06
s.dist -0.425
p.adjustANOVA 0.00013



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
APOL1 -7818
SCARA5 -7167
JCHAIN -7064
MARCO -6924
HP -6427
STAB1 -6285
FTL -6137
SSC5D -6127
COL1A1 -5999
MSR1 -5706
LRP1 -5611
HYOU1 -5569
CD163 -5242
APOE -5210
COL1A2 -4914
COLEC12 -4864
IGHA2 -4762

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGLC1 -8528
IGLC3 -8412
IGLC2 -7870
APOL1 -7818
SCARA5 -7167
JCHAIN -7064
MARCO -6924
HP -6427
STAB1 -6285
FTL -6137
SSC5D -6127
COL1A1 -5999
MSR1 -5706
LRP1 -5611
HYOU1 -5569
CD163 -5242
APOE -5210
COL1A2 -4914
COLEC12 -4864
IGHA2 -4762
HSP90B1 -3626
SCARF1 -3471
APOB -3167
SCARB1 -3087
MASP1 -2834
FTH1 -2755
COL4A2 -2649
CALR -2533
SPARC -2263
HPX -1382
IGHA1 -1345
IGKC -1151
COL3A1 -1131
CD36 -683
COL4A1 -331
HBB 39
HBA1 1971
HSP90AA1 6198
HSPH1 7843


Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
32
set Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
setSize 12
pANOVA 0.0109
s.dist 0.425
p.adjustANOVA 0.0917



Top enriched genes

Top 20 genes
GeneID Gene Rank
AR 7372
H2AJ 6939
H2BC12 6804
H2BC21 6751
H2BC5 5011
H2AZ2 3625
H2AC18 3523
H2AC6 2326
KDM1A 1611
KDM4C 1516
PKN1 -145
NCOA2 -1311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AR 7372
H2AJ 6939
H2BC12 6804
H2BC21 6751
H2BC5 5011
H2AZ2 3625
H2AC18 3523
H2AC6 2326
KDM1A 1611
KDM4C 1516
PKN1 -145
NCOA2 -1311


Synthesis of PIPs at the Golgi membrane

Synthesis of PIPs at the Golgi membrane
1282
set Synthesis of PIPs at the Golgi membrane
setSize 15
pANOVA 0.00548
s.dist -0.414
p.adjustANOVA 0.0552



Top enriched genes

Top 20 genes
GeneID Gene Rank
VAC14 -7867
PI4K2A -7813
ARF3 -6721
PI4KA -6679
PI4KB -6426
OCRL -4561
FIG4 -4515
PI4K2B -4209
INPP5E -4082
PIK3R4 -3943
PIKFYVE -3536
SACM1L -2456
ARF1 -1242
PIK3C2A 4227
PIK3C3 6135

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VAC14 -7867
PI4K2A -7813
ARF3 -6721
PI4KA -6679
PI4KB -6426
OCRL -4561
FIG4 -4515
PI4K2B -4209
INPP5E -4082
PIK3R4 -3943
PIKFYVE -3536
SACM1L -2456
ARF1 -1242
PIK3C2A 4227
PIK3C3 6135


Other semaphorin interactions

Other semaphorin interactions
820
set Other semaphorin interactions
setSize 19
pANOVA 0.00187
s.dist -0.412
p.adjustANOVA 0.0229



Top enriched genes

Top 20 genes
GeneID Gene Rank
SEMA5A -8623
CD72 -8617
SEMA6D -8294
PLXNA1 -8165
SEMA4D -7686
PLXNC1 -7303
PTPRC -7022
SEMA7A -6174
SEMA4A -5766
TYROBP -5596
PLXND1 -4500
PLXNB3 -4411
TREM2 -2912
ITGB1 -705
PLXNA4 656
SEMA3E 1388
PLXNA2 1738
SEMA6A 6191
ITGA1 8158

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SEMA5A -8623
CD72 -8617
SEMA6D -8294
PLXNA1 -8165
SEMA4D -7686
PLXNC1 -7303
PTPRC -7022
SEMA7A -6174
SEMA4A -5766
TYROBP -5596
PLXND1 -4500
PLXNB3 -4411
TREM2 -2912
ITGB1 -705
PLXNA4 656
SEMA3E 1388
PLXNA2 1738
SEMA6A 6191
ITGA1 8158


Role of phospholipids in phagocytosis

Role of phospholipids in phagocytosis
1102
set Role of phospholipids in phagocytosis
setSize 32
pANOVA 6.82e-05
s.dist -0.407
p.adjustANOVA 0.00153



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
FCGR2A -8279
FCGR1A -8113
FCGR3A -7985
IGLC2 -7870
PLPP5 -7209
PRKCD -7187
PIK3R2 -7148
SYK -7142
IGHG2 -6973
IGHG1 -6890
CD247 -6839
AHCYL1 -5817
PLD3 -5155
IGHG3 -4982
PLD1 -3828
PLD2 -2904
ITPR3 -2786

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGHG4 -8636
IGLC1 -8528
IGLC3 -8412
FCGR2A -8279
FCGR1A -8113
FCGR3A -7985
IGLC2 -7870
PLPP5 -7209
PRKCD -7187
PIK3R2 -7148
SYK -7142
IGHG2 -6973
IGHG1 -6890
CD247 -6839
AHCYL1 -5817
PLD3 -5155
IGHG3 -4982
PLD1 -3828
PLD2 -2904
ITPR3 -2786
ITPR2 -1777
PIK3CB -1354
IGKC -1151
PLD4 -321
PLA2G6 572
PLCG1 702
PIK3CA 1041
PRKCE 2755
ITPR1 3726
PIK3R1 3780
PLCG2 6019
CD3G 6329


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               zlibbioc_1.48.0         cachem_1.0.8           
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.8             
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report