date generated: 2024-02-26

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -6.143587
7SK -1.282326
A1BG -4.436253
A1BG.AS1 -1.588745
A2M 2.397394
A2M.AS1 2.213143

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 16680
duplicated_genes_present 0
num_profile_genes_in_sets 8318
num_profile_genes_not_in_sets 8362

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1141
num_genesets_included 1471

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 1.56e-05 -0.692 1.10e-04
Formation of tubulin folding intermediates by CCT/TriC 21 1.95e-07 -0.656 2.09e-06
Transport of connexons to the plasma membrane 14 4.42e-05 -0.630 2.94e-04
Folding of actin by CCT/TriC 10 8.71e-04 -0.608 4.37e-03
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.32e-07 -0.597 2.40e-06
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 7.05e-08 -0.588 8.37e-07
Eukaryotic Translation Elongation 92 6.24e-22 -0.580 1.15e-19
Josephin domain DUBs 10 1.69e-03 -0.573 7.89e-03
Peptide chain elongation 87 2.25e-20 -0.573 1.84e-18
TP53 Regulates Transcription of Death Receptors and Ligands 10 1.84e-03 -0.569 8.53e-03
Gluconeogenesis 27 3.56e-07 -0.566 3.44e-06
Viral mRNA Translation 87 7.33e-20 -0.565 5.00e-18
Erythrocytes take up carbon dioxide and release oxygen 10 2.01e-03 -0.564 9.13e-03
O2/CO2 exchange in erythrocytes 10 2.01e-03 -0.564 9.13e-03
Keratan sulfate biosynthesis 26 6.42e-07 -0.564 6.02e-06
Eukaryotic Translation Termination 91 7.47e-20 -0.553 5.00e-18
STAT3 nuclear events downstream of ALK signaling 10 2.81e-03 -0.546 1.22e-02
SARS-CoV-1 modulates host translation machinery 36 1.45e-08 -0.546 2.00e-07
Formation of a pool of free 40S subunits 99 1.09e-20 -0.542 1.12e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 2.33e-19 -0.539 1.49e-17
Syndecan interactions 26 2.00e-06 -0.539 1.61e-05
SRP-dependent cotranslational protein targeting to membrane 110 4.00e-22 -0.533 8.41e-20
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.47e-03 0.530 6.91e-03
Selenocysteine synthesis 91 2.70e-18 -0.529 1.47e-16
Suppression of phagosomal maturation 13 9.79e-04 -0.528 4.87e-03
L13a-mediated translational silencing of Ceruloplasmin expression 109 1.67e-21 -0.528 2.05e-19
Chondroitin sulfate biosynthesis 16 2.93e-04 -0.523 1.64e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 110 4.06e-21 -0.520 4.60e-19
Activation of Matrix Metalloproteinases 23 1.61e-05 -0.520 1.13e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 6.14e-19 -0.517 3.48e-17
Keratan sulfate degradation 13 1.31e-03 -0.515 6.34e-03
Crosslinking of collagen fibrils 14 9.02e-04 -0.512 4.50e-03
Cap-dependent Translation Initiation 117 1.19e-21 -0.511 1.59e-19
Eukaryotic Translation Initiation 117 1.19e-21 -0.511 1.59e-19
ATF6 (ATF6-alpha) activates chaperones 12 2.23e-03 -0.510 1.00e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 70 1.95e-13 -0.508 6.66e-12
Formation of ATP by chemiosmotic coupling 16 5.09e-04 -0.502 2.69e-03
Ubiquitin-dependent degradation of Cyclin D 50 1.02e-09 -0.499 2.06e-08
Formation of the ternary complex, and subsequently, the 43S complex 51 7.02e-10 -0.499 1.50e-08
Selenoamino acid metabolism 113 6.11e-20 -0.498 4.49e-18
Diseases associated with glycosaminoglycan metabolism 38 1.11e-07 -0.497 1.26e-06
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 6.60e-03 -0.496 2.55e-02
FGFR2 ligand binding and activation 10 6.97e-03 -0.493 2.67e-02
Downregulation of ERBB2:ERBB3 signaling 13 2.11e-03 -0.492 9.55e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 1.44e-03 -0.492 6.87e-03
Membrane binding and targetting of GAG proteins 14 1.45e-03 -0.491 6.87e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.45e-03 -0.491 6.87e-03
Keratan sulfate/keratin metabolism 32 1.58e-06 -0.490 1.30e-05
Diseases associated with glycosylation precursor biosynthesis 15 1.02e-03 -0.490 5.03e-03
Regulation of RUNX3 expression and activity 55 4.18e-10 -0.487 9.45e-09


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 1.56e-05 -0.692000 1.10e-04
Formation of tubulin folding intermediates by CCT/TriC 21 1.95e-07 -0.656000 2.09e-06
Transport of connexons to the plasma membrane 14 4.42e-05 -0.630000 2.94e-04
Folding of actin by CCT/TriC 10 8.71e-04 -0.608000 4.37e-03
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.32e-07 -0.597000 2.40e-06
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 7.05e-08 -0.588000 8.37e-07
Eukaryotic Translation Elongation 92 6.24e-22 -0.580000 1.15e-19
Josephin domain DUBs 10 1.69e-03 -0.573000 7.89e-03
Peptide chain elongation 87 2.25e-20 -0.573000 1.84e-18
TP53 Regulates Transcription of Death Receptors and Ligands 10 1.84e-03 -0.569000 8.53e-03
Gluconeogenesis 27 3.56e-07 -0.566000 3.44e-06
Viral mRNA Translation 87 7.33e-20 -0.565000 5.00e-18
Erythrocytes take up carbon dioxide and release oxygen 10 2.01e-03 -0.564000 9.13e-03
O2/CO2 exchange in erythrocytes 10 2.01e-03 -0.564000 9.13e-03
Keratan sulfate biosynthesis 26 6.42e-07 -0.564000 6.02e-06
Eukaryotic Translation Termination 91 7.47e-20 -0.553000 5.00e-18
STAT3 nuclear events downstream of ALK signaling 10 2.81e-03 -0.546000 1.22e-02
SARS-CoV-1 modulates host translation machinery 36 1.45e-08 -0.546000 2.00e-07
Formation of a pool of free 40S subunits 99 1.09e-20 -0.542000 1.12e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 2.33e-19 -0.539000 1.49e-17
Syndecan interactions 26 2.00e-06 -0.539000 1.61e-05
SRP-dependent cotranslational protein targeting to membrane 110 4.00e-22 -0.533000 8.41e-20
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.47e-03 0.530000 6.91e-03
Selenocysteine synthesis 91 2.70e-18 -0.529000 1.47e-16
Suppression of phagosomal maturation 13 9.79e-04 -0.528000 4.87e-03
L13a-mediated translational silencing of Ceruloplasmin expression 109 1.67e-21 -0.528000 2.05e-19
Chondroitin sulfate biosynthesis 16 2.93e-04 -0.523000 1.64e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 110 4.06e-21 -0.520000 4.60e-19
Activation of Matrix Metalloproteinases 23 1.61e-05 -0.520000 1.13e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 6.14e-19 -0.517000 3.48e-17
Keratan sulfate degradation 13 1.31e-03 -0.515000 6.34e-03
Crosslinking of collagen fibrils 14 9.02e-04 -0.512000 4.50e-03
Cap-dependent Translation Initiation 117 1.19e-21 -0.511000 1.59e-19
Eukaryotic Translation Initiation 117 1.19e-21 -0.511000 1.59e-19
ATF6 (ATF6-alpha) activates chaperones 12 2.23e-03 -0.510000 1.00e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 70 1.95e-13 -0.508000 6.66e-12
Formation of ATP by chemiosmotic coupling 16 5.09e-04 -0.502000 2.69e-03
Ubiquitin-dependent degradation of Cyclin D 50 1.02e-09 -0.499000 2.06e-08
Formation of the ternary complex, and subsequently, the 43S complex 51 7.02e-10 -0.499000 1.50e-08
Selenoamino acid metabolism 113 6.11e-20 -0.498000 4.49e-18
Diseases associated with glycosaminoglycan metabolism 38 1.11e-07 -0.497000 1.26e-06
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 6.60e-03 -0.496000 2.55e-02
FGFR2 ligand binding and activation 10 6.97e-03 -0.493000 2.67e-02
Downregulation of ERBB2:ERBB3 signaling 13 2.11e-03 -0.492000 9.55e-03
Response of EIF2AK1 (HRI) to heme deficiency 14 1.44e-03 -0.492000 6.87e-03
Membrane binding and targetting of GAG proteins 14 1.45e-03 -0.491000 6.87e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.45e-03 -0.491000 6.87e-03
Keratan sulfate/keratin metabolism 32 1.58e-06 -0.490000 1.30e-05
Diseases associated with glycosylation precursor biosynthesis 15 1.02e-03 -0.490000 5.03e-03
Regulation of RUNX3 expression and activity 55 4.18e-10 -0.487000 9.45e-09
IRE1alpha activates chaperones 49 4.10e-09 -0.485000 7.05e-08
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 1.30e-10 -0.484000 3.35e-09
Regulation of ornithine decarboxylase (ODC) 48 8.75e-09 -0.480000 1.29e-07
Ribosomal scanning and start codon recognition 58 2.71e-10 -0.479000 6.54e-09
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 6.74e-09 -0.479000 1.05e-07
p53-Independent DNA Damage Response 49 6.74e-09 -0.479000 1.05e-07
p53-Independent G1/S DNA damage checkpoint 49 6.74e-09 -0.479000 1.05e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.08e-08 -0.477000 1.57e-07
Translation initiation complex formation 58 3.39e-10 -0.477000 8.04e-09
XBP1(S) activates chaperone genes 47 1.64e-08 -0.476000 2.19e-07
ATF6 (ATF6-alpha) activates chaperone genes 10 9.22e-03 -0.476000 3.42e-02
Hh mutants are degraded by ERAD 53 2.16e-09 -0.475000 3.93e-08
Autodegradation of the E3 ubiquitin ligase COP1 49 1.14e-08 -0.471000 1.64e-07
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 3.30e-09 -0.470000 5.84e-08
Transferrin endocytosis and recycling 28 1.78e-05 -0.469000 1.23e-04
Insulin receptor recycling 26 3.85e-05 -0.466000 2.59e-04
Degradation of DVL 55 2.22e-09 -0.466000 3.98e-08
Glycogen synthesis 12 5.28e-03 -0.465000 2.08e-02
Assembly Of The HIV Virion 16 1.32e-03 -0.464000 6.39e-03
Vif-mediated degradation of APOBEC3G 52 7.69e-09 -0.463000 1.17e-07
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 2.19e-17 -0.462000 1.07e-15
Nonsense-Mediated Decay (NMD) 113 2.19e-17 -0.462000 1.07e-15
Negative regulation of NOTCH4 signaling 54 5.18e-09 -0.459000 8.65e-08
Defective CFTR causes cystic fibrosis 59 1.09e-09 -0.459000 2.12e-08
Collagen biosynthesis and modifying enzymes 60 8.18e-10 -0.458000 1.69e-08
Hh mutants abrogate ligand secretion 55 4.17e-09 -0.458000 7.05e-08
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 8.32e-09 -0.457000 1.24e-07
Vpu mediated degradation of CD4 50 2.57e-08 -0.455000 3.32e-07
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 1.41e-08 -0.455000 1.96e-07
Metabolism of polyamines 56 4.17e-09 -0.454000 7.05e-08
Scavenging of heme from plasma 13 4.79e-03 -0.452000 1.91e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 4.10e-10 -0.452000 9.45e-09
Antimicrobial peptides 26 6.78e-05 -0.451000 4.41e-04
SHC-mediated cascade:FGFR3 12 6.83e-03 -0.451000 2.63e-02
SCF-beta-TrCP mediated degradation of Emi1 53 1.38e-08 -0.451000 1.93e-07
Dectin-1 mediated noncanonical NF-kB signaling 58 3.36e-09 -0.449000 5.88e-08
Defective Intrinsic Pathway for Apoptosis 21 3.75e-04 -0.448000 2.03e-03
Chemokine receptors bind chemokines 36 3.28e-06 -0.448000 2.57e-05
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.55e-07 -0.447000 1.69e-06
The canonical retinoid cycle in rods (twilight vision) 11 1.05e-02 0.445000 3.83e-02
Post-chaperonin tubulin folding pathway 18 1.10e-03 -0.444000 5.44e-03
Collagen degradation 54 1.66e-08 -0.444000 2.20e-07
Zinc transporters 10 1.51e-02 -0.444000 5.22e-02
NIK–>noncanonical NF-kB signaling 57 7.47e-09 -0.443000 1.14e-07
Cristae formation 29 3.94e-05 -0.441000 2.64e-04
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.47e-04 -0.441000 1.91e-03
Stabilization of p53 54 2.48e-08 -0.439000 3.23e-07
Regulation of expression of SLITs and ROBOs 162 9.58e-22 -0.436000 1.57e-19
GLI3 is processed to GLI3R by the proteasome 57 1.38e-08 -0.435000 1.93e-07
Regulation of Apoptosis 51 8.75e-08 -0.433000 1.01e-06
DARPP-32 events 22 4.62e-04 -0.431000 2.45e-03
FGFR2 mutant receptor activation 24 2.89e-04 -0.428000 1.62e-03
Regulation of BACH1 activity 11 1.42e-02 -0.427000 4.98e-02
SCF(Skp2)-mediated degradation of p27/p21 59 1.50e-08 -0.426000 2.04e-07
NF-kB is activated and signals survival 13 7.81e-03 -0.426000 2.95e-02
Degradation of GLI2 by the proteasome 57 2.69e-08 -0.426000 3.44e-07
Cytosolic tRNA aminoacylation 24 3.15e-04 -0.425000 1.75e-03
Cellular response to starvation 149 4.98e-19 -0.423000 2.93e-17
Regulation of RUNX2 expression and activity 70 9.61e-10 -0.423000 1.96e-08
Metabolism of Angiotensinogen to Angiotensins 13 8.34e-03 -0.423000 3.13e-02
Hedgehog ligand biogenesis 60 1.56e-08 -0.422000 2.10e-07
Collagen chain trimerization 38 7.11e-06 -0.421000 5.28e-05
Gap junction assembly 21 8.74e-04 -0.420000 4.37e-03
Activation of NF-kappaB in B cells 65 5.77e-09 -0.418000 9.54e-08
Beta-catenin phosphorylation cascade 17 2.97e-03 -0.416000 1.29e-02
SHC-mediated cascade:FGFR4 11 1.69e-02 -0.416000 5.74e-02
Downstream TCR signaling 82 8.24e-11 -0.415000 2.20e-09
Nuclear events mediated by NFE2L2 76 4.13e-10 -0.415000 9.45e-09
Degradation of GLI1 by the proteasome 57 6.85e-08 -0.413000 8.32e-07
Cellular response to hypoxia 72 1.43e-09 -0.413000 2.69e-08
Interleukin-10 signaling 35 2.41e-05 -0.412000 1.65e-04
Pentose phosphate pathway 13 1.00e-02 -0.412000 3.69e-02
Signaling by FGFR2 IIIa TM 19 1.93e-03 -0.411000 8.89e-03
PD-1 signaling 11 1.85e-02 -0.410000 6.19e-02
SUMOylation of immune response proteins 11 1.86e-02 -0.410000 6.22e-02
Assembly of collagen fibrils and other multimeric structures 54 2.06e-07 -0.409000 2.17e-06
Degradation of beta-catenin by the destruction complex 83 1.26e-10 -0.408000 3.32e-09
Asymmetric localization of PCP proteins 61 3.65e-08 -0.408000 4.59e-07
Collagen formation 81 2.31e-10 -0.407000 5.68e-09
Striated Muscle Contraction 30 1.14e-04 -0.407000 7.04e-04
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.94e-02 -0.407000 6.46e-02
TICAM1-dependent activation of IRF3/IRF7 12 1.48e-02 -0.406000 5.13e-02
Degradation of AXIN 53 3.16e-07 -0.406000 3.10e-06
Translation 291 1.19e-32 -0.405000 4.39e-30
COPI-mediated anterograde transport 92 1.85e-11 -0.405000 5.22e-10
SARS-CoV-2 modulates host translation machinery 49 1.12e-06 -0.402000 9.49e-06
SHC-mediated cascade:FGFR2 14 9.41e-03 -0.401000 3.49e-02
RUNX3 regulates p14-ARF 10 2.92e-02 -0.398000 9.01e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 3.47e-03 -0.398000 1.45e-02
Neurodegenerative Diseases 18 3.47e-03 -0.398000 1.45e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 24 7.43e-04 -0.398000 3.82e-03
Pausing and recovery of Tat-mediated HIV elongation 30 1.67e-04 -0.397000 9.89e-04
Tat-mediated HIV elongation arrest and recovery 30 1.67e-04 -0.397000 9.89e-04
Interconversion of nucleotide di- and triphosphates 27 3.57e-04 -0.397000 1.94e-03
p53-Dependent G1 DNA Damage Response 62 7.04e-08 -0.396000 8.37e-07
p53-Dependent G1/S DNA damage checkpoint 62 7.04e-08 -0.396000 8.37e-07
Cargo concentration in the ER 28 3.13e-04 -0.394000 1.75e-03
SLBP independent Processing of Histone Pre-mRNAs 10 3.14e-02 -0.393000 9.53e-02
Unwinding of DNA 11 2.47e-02 -0.391000 7.79e-02
Orc1 removal from chromatin 67 3.58e-08 -0.389000 4.54e-07
KEAP1-NFE2L2 pathway 101 1.48e-11 -0.389000 4.27e-10
Assembly of active LPL and LIPC lipase complexes 12 1.98e-02 -0.389000 6.50e-02
Regulation of NPAS4 gene expression 12 2.01e-02 0.388000 6.56e-02
G1/S DNA Damage Checkpoints 63 1.06e-07 -0.387000 1.21e-06
Unfolded Protein Response (UPR) 91 2.15e-10 -0.385000 5.37e-09
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 3.85e-08 -0.383000 4.79e-07
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 2.86e-02 -0.381000 8.87e-02
Anchoring fibril formation 11 2.88e-02 -0.381000 8.92e-02
Mitochondrial protein import 63 2.00e-07 -0.379000 2.12e-06
N-Glycan antennae elongation 13 1.85e-02 -0.377000 6.19e-02
Somitogenesis 50 4.38e-06 -0.375000 3.34e-05
Assembly and cell surface presentation of NMDA receptors 34 1.54e-04 -0.375000 9.32e-04
Phosphorylation of CD3 and TCR zeta chains 11 3.13e-02 -0.375000 9.53e-02
TNFR2 non-canonical NF-kB pathway 87 1.57e-09 -0.374000 2.92e-08
Regulation of PTEN stability and activity 67 1.17e-07 -0.374000 1.31e-06
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 87 1.63e-09 -0.374000 3.00e-08
The activation of arylsulfatases 10 4.05e-02 -0.374000 1.15e-01
Interleukin-4 and Interleukin-13 signaling 90 1.04e-09 -0.372000 2.07e-08
FCERI mediated NF-kB activation 81 7.10e-09 -0.372000 1.10e-07
Influenza Viral RNA Transcription and Replication 134 1.05e-13 -0.372000 3.78e-12
APC/C:Cdc20 mediated degradation of Securin 66 1.75e-07 -0.372000 1.89e-06
Post-translational protein phosphorylation 78 1.37e-08 -0.372000 1.93e-07
Autodegradation of Cdh1 by Cdh1:APC/C 64 3.15e-07 -0.370000 3.10e-06
Transcriptional regulation by RUNX3 94 6.11e-10 -0.369000 1.32e-08
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.27e-03 -0.368000 1.02e-02
Signaling by ROBO receptors 201 2.82e-19 -0.367000 1.73e-17
Regulation of TP53 Activity through Association with Co-factors 10 4.46e-02 -0.367000 1.21e-01
Degradation of cysteine and homocysteine 12 2.78e-02 -0.367000 8.66e-02
Aggrephagy 35 1.91e-04 -0.364000 1.12e-03
MASTL Facilitates Mitotic Progression 10 4.61e-02 -0.364000 1.24e-01
Iron uptake and transport 55 3.32e-06 -0.363000 2.58e-05
COPI-dependent Golgi-to-ER retrograde traffic 86 6.50e-09 -0.362000 1.05e-07
ER to Golgi Anterograde Transport 141 1.26e-13 -0.362000 4.42e-12
Transcriptional regulation by RUNX2 114 2.65e-11 -0.361000 7.23e-10
PINK1-PRKN Mediated Mitophagy 21 4.19e-03 -0.361000 1.71e-02
HSF1 activation 25 1.80e-03 -0.361000 8.37e-03
Common Pathway of Fibrin Clot Formation 10 4.91e-02 -0.359000 1.31e-01
Chondroitin sulfate/dermatan sulfate metabolism 45 3.09e-05 -0.359000 2.09e-04
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 3.93e-02 -0.359000 1.12e-01
ABC transporter disorders 69 2.75e-07 -0.358000 2.75e-06
p75NTR signals via NF-kB 16 1.33e-02 -0.358000 4.72e-02
RHO GTPases activate IQGAPs 24 2.47e-03 -0.357000 1.09e-02
Complex I biogenesis 51 1.09e-05 -0.356000 7.84e-05
Response of Mtb to phagocytosis 23 3.22e-03 -0.355000 1.36e-02
Interleukin-2 signaling 11 4.16e-02 -0.355000 1.17e-01
Negative regulation of FGFR3 signaling 23 3.27e-03 -0.354000 1.37e-02
Integrin cell surface interactions 73 1.99e-07 -0.352000 2.12e-06
Packaging Of Telomere Ends 12 3.59e-02 -0.350000 1.06e-01
Respiratory electron transport 93 5.96e-09 -0.349000 9.75e-08
TCR signaling 102 1.22e-09 -0.348000 2.33e-08
Dectin-2 family 14 2.44e-02 0.347000 7.71e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 3.46e-07 -0.347000 3.37e-06
Mitochondrial iron-sulfur cluster biogenesis 13 3.06e-02 -0.346000 9.34e-02
CTNNB1 S33 mutants aren’t phosphorylated 15 2.05e-02 -0.346000 6.60e-02
CTNNB1 S37 mutants aren’t phosphorylated 15 2.05e-02 -0.346000 6.60e-02
CTNNB1 S45 mutants aren’t phosphorylated 15 2.05e-02 -0.346000 6.60e-02
CTNNB1 T41 mutants aren’t phosphorylated 15 2.05e-02 -0.346000 6.60e-02
Signaling by CTNNB1 phospho-site mutants 15 2.05e-02 -0.346000 6.60e-02
Signaling by GSK3beta mutants 15 2.05e-02 -0.346000 6.60e-02
Cohesin Loading onto Chromatin 10 5.84e-02 0.346000 1.47e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 1.37e-02 -0.345000 4.84e-02
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 1.37e-02 -0.345000 4.84e-02
Downstream signaling events of B Cell Receptor (BCR) 78 1.34e-07 -0.345000 1.50e-06
Major pathway of rRNA processing in the nucleolus and cytosol 179 1.65e-15 -0.345000 6.57e-14
Maturation of spike protein 9694548 37 2.84e-04 -0.345000 1.60e-03
IL-6-type cytokine receptor ligand interactions 13 3.14e-02 -0.345000 9.54e-02
Free fatty acids regulate insulin secretion 10 5.95e-02 0.344000 1.48e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 3.90e-02 0.344000 1.11e-01
Metal ion SLC transporters 18 1.19e-02 -0.342000 4.29e-02
HIV elongation arrest and recovery 32 8.14e-04 -0.342000 4.11e-03
Pausing and recovery of HIV elongation 32 8.14e-04 -0.342000 4.11e-03
Signaling by ALK 27 2.12e-03 -0.342000 9.55e-03
CS/DS degradation 11 4.97e-02 -0.342000 1.31e-01
Interleukin-1 signaling 109 7.85e-10 -0.341000 1.65e-08
Attenuation phase 22 5.75e-03 -0.340000 2.24e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 4.44e-10 -0.340000 9.89e-09
rRNA processing in the nucleus and cytosol 189 8.24e-16 -0.340000 3.37e-14
E3 ubiquitin ligases ubiquitinate target proteins 43 1.18e-04 -0.339000 7.23e-04
APC/C:Cdc20 mediated degradation of mitotic proteins 72 6.67e-07 -0.339000 6.12e-06
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 5.70e-07 -0.339000 5.37e-06
Mitophagy 28 1.94e-03 -0.338000 8.90e-03
CDK-mediated phosphorylation and removal of Cdc6 70 1.00e-06 -0.338000 8.55e-06
Mitochondrial translation elongation 88 4.24e-08 -0.338000 5.24e-07
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 2.47e-03 -0.337000 1.09e-02
Acetylcholine Neurotransmitter Release Cycle 13 3.57e-02 -0.336000 1.05e-01
Serotonin Neurotransmitter Release Cycle 15 2.41e-02 -0.336000 7.65e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 49 4.73e-05 -0.336000 3.13e-04
Influenza Infection 153 8.23e-13 -0.335000 2.58e-11
Interleukin-6 family signaling 20 9.54e-03 -0.335000 3.52e-02
P2Y receptors 11 5.45e-02 0.335000 1.40e-01
Inactivation of CSF3 (G-CSF) signaling 24 4.54e-03 -0.335000 1.83e-02
Negative regulation of FGFR2 signaling 25 3.85e-03 -0.334000 1.58e-02
Glycogen storage diseases 13 3.72e-02 -0.334000 1.07e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 1.40e-06 -0.334000 1.17e-05
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 1.40e-06 -0.334000 1.17e-05
Regulation of RAS by GAPs 65 3.58e-06 -0.332000 2.75e-05
Negative regulation of FGFR4 signaling 22 6.97e-03 -0.332000 2.67e-02
Cyclin E associated events during G1/S transition 81 2.58e-07 -0.331000 2.60e-06
Dopamine Neurotransmitter Release Cycle 20 1.04e-02 -0.331000 3.80e-02
Assembly of the pre-replicative complex 88 8.14e-08 -0.331000 9.50e-07
Budding and maturation of HIV virion 27 3.08e-03 -0.329000 1.32e-02
Inhibition of DNA recombination at telomere 26 3.71e-03 -0.329000 1.54e-02
Transport to the Golgi and subsequent modification 166 2.82e-13 -0.329000 9.43e-12
NGF-stimulated transcription 35 8.10e-04 -0.327000 4.11e-03
rRNA processing 199 2.31e-15 -0.326000 8.93e-14
Lewis blood group biosynthesis 10 7.53e-02 -0.325000 1.78e-01
Long-term potentiation 19 1.45e-02 -0.324000 5.03e-02
Mitochondrial translation termination 88 1.51e-07 -0.324000 1.66e-06
COPII-mediated vesicle transport 63 9.06e-06 -0.323000 6.57e-05
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 1.35e-03 -0.322000 6.49e-03
Cyclin A:Cdk2-associated events at S phase entry 83 3.90e-07 -0.322000 3.75e-06
AKT phosphorylates targets in the cytosol 14 3.70e-02 -0.322000 1.07e-01
Regulation of APC/C activators between G1/S and early anaphase 78 9.68e-07 -0.321000 8.33e-06
PCP/CE pathway 87 2.44e-07 -0.320000 2.51e-06
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 4.60e-02 -0.320000 1.24e-01
Elastic fibre formation 40 4.93e-04 -0.318000 2.61e-03
Mitochondrial translation initiation 88 2.53e-07 -0.318000 2.57e-06
Translation of Structural Proteins 9683701 29 3.09e-03 -0.318000 1.32e-02
Pyrimidine salvage 10 8.32e-02 -0.316000 1.92e-01
ROS and RNS production in phagocytes 31 2.33e-03 -0.316000 1.04e-02
N-glycan antennae elongation in the medial/trans-Golgi 20 1.45e-02 -0.316000 5.05e-02
Hedgehog ‘on’ state 82 8.60e-07 -0.314000 7.57e-06
Processing and activation of SUMO 10 8.58e-02 -0.314000 1.97e-01
Infection with Mycobacterium tuberculosis 27 5.02e-03 -0.312000 1.98e-02
TCF dependent signaling in response to WNT 160 1.00e-11 -0.312000 2.95e-10
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.13e-03 -0.312000 1.33e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 30 3.18e-03 -0.311000 1.34e-02
Protein ubiquitination 63 2.01e-05 -0.311000 1.38e-04
Lysine catabolism 11 7.51e-02 0.310000 1.78e-01
Norepinephrine Neurotransmitter Release Cycle 15 3.79e-02 -0.310000 1.09e-01
CTLA4 inhibitory signaling 19 1.96e-02 -0.309000 6.47e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 3.90e-02 -0.308000 1.11e-01
A tetrasaccharide linker sequence is required for GAG synthesis 22 1.24e-02 -0.308000 4.44e-02
Phase 4 - resting membrane potential 12 6.52e-02 -0.307000 1.59e-01
CLEC7A (Dectin-1) signaling 95 2.26e-07 -0.307000 2.36e-06
Golgi-to-ER retrograde transport 119 7.81e-09 -0.306000 1.17e-07
Switching of origins to a post-replicative state 88 6.81e-07 -0.306000 6.18e-06
ABC transporters in lipid homeostasis 12 6.71e-02 0.305000 1.63e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 10 9.63e-02 0.304000 2.15e-01
Calnexin/calreticulin cycle 26 7.47e-03 -0.303000 2.84e-02
APC truncation mutants have impaired AXIN binding 14 4.97e-02 -0.303000 1.31e-01
AXIN missense mutants destabilize the destruction complex 14 4.97e-02 -0.303000 1.31e-01
Signaling by AMER1 mutants 14 4.97e-02 -0.303000 1.31e-01
Signaling by APC mutants 14 4.97e-02 -0.303000 1.31e-01
Signaling by AXIN mutants 14 4.97e-02 -0.303000 1.31e-01
Truncations of AMER1 destabilize the destruction complex 14 4.97e-02 -0.303000 1.31e-01
Interleukin-7 signaling 19 2.22e-02 -0.303000 7.10e-02
Activation of AMPK downstream of NMDARs 21 1.64e-02 -0.303000 5.63e-02
HSF1-dependent transactivation 32 3.07e-03 -0.302000 1.32e-02
Asparagine N-linked glycosylation 279 4.11e-18 -0.302000 2.16e-16
Defective B4GALT7 causes EDS, progeroid type 17 3.12e-02 -0.302000 9.53e-02
Mitochondrial translation 94 4.30e-07 -0.302000 4.08e-06
Negative regulation of MAPK pathway 42 7.23e-04 -0.302000 3.74e-03
ECM proteoglycans 61 4.77e-05 -0.301000 3.14e-04
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 3.71e-02 -0.301000 1.07e-01
Nucleotide salvage 21 1.74e-02 -0.300000 5.88e-02
Senescence-Associated Secretory Phenotype (SASP) 56 1.24e-04 -0.297000 7.57e-04
COPI-independent Golgi-to-ER retrograde traffic 45 5.90e-04 -0.296000 3.09e-03
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.47e-03 -0.296000 1.09e-02
FCGR activation 19 2.58e-02 -0.295000 8.10e-02
Generation of second messenger molecules 21 1.96e-02 -0.294000 6.47e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 3.59e-02 -0.294000 1.06e-01
Acyl chain remodelling of PC 17 3.65e-02 0.293000 1.07e-01
Defective B3GAT3 causes JDSSDHD 17 3.66e-02 -0.293000 1.07e-01
Pexophagy 11 9.28e-02 -0.293000 2.09e-01
Unblocking of NMDA receptors, glutamate binding and activation 17 3.67e-02 -0.293000 1.07e-01
UCH proteinases 85 3.13e-06 -0.293000 2.46e-05
APC/C-mediated degradation of cell cycle proteins 84 3.59e-06 -0.293000 2.75e-05
Regulation of mitotic cell cycle 84 3.59e-06 -0.293000 2.75e-05
Late endosomal microautophagy 32 4.20e-03 -0.292000 1.71e-02
ER-Phagosome pathway 79 7.48e-06 -0.292000 5.50e-05
Negative regulation of NMDA receptor-mediated neuronal transmission 16 4.39e-02 -0.291000 1.20e-01
Cleavage of the damaged purine 15 5.32e-02 -0.288000 1.38e-01
Depurination 15 5.32e-02 -0.288000 1.38e-01
Recognition and association of DNA glycosylase with site containing an affected purine 15 5.32e-02 -0.288000 1.38e-01
Cellular response to chemical stress 183 2.08e-11 -0.287000 5.79e-10
Extracellular matrix organization 250 5.80e-15 -0.287000 2.13e-13
RAS processing 21 2.34e-02 -0.286000 7.44e-02
The citric acid (TCA) cycle and respiratory electron transport 160 4.92e-10 -0.285000 1.08e-08
MET activates RAP1 and RAC1 11 1.02e-01 0.285000 2.24e-01
Glycosaminoglycan metabolism 110 2.48e-07 -0.285000 2.53e-06
NFE2L2 regulating anti-oxidant/detoxification enzymes 14 6.50e-02 -0.285000 1.59e-01
MAPK6/MAPK4 signaling 83 8.08e-06 -0.283000 5.92e-05
Regulation of mRNA stability by proteins that bind AU-rich elements 87 5.09e-06 -0.283000 3.86e-05
tRNA Aminoacylation 42 1.54e-03 -0.283000 7.22e-03
VLDLR internalisation and degradation 15 5.82e-02 -0.283000 1.47e-01
Translation of Structural Proteins 9694635 57 2.58e-04 -0.280000 1.47e-03
Regulation of TP53 Expression and Degradation 36 3.68e-03 -0.280000 1.53e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 8.20e-02 -0.279000 1.90e-01
Hedgehog ‘off’ state 106 7.96e-07 -0.278000 7.15e-06
Non-integrin membrane-ECM interactions 54 4.28e-04 -0.277000 2.30e-03
Synthesis of PIPs at the early endosome membrane 16 5.51e-02 0.277000 1.41e-01
Metabolism of amino acids and derivatives 316 2.94e-17 -0.277000 1.40e-15
ERKs are inactivated 13 8.41e-02 -0.277000 1.94e-01
DNA Replication Pre-Initiation 102 1.42e-06 -0.276000 1.18e-05
Ras activation upon Ca2+ influx through NMDA receptor 16 5.68e-02 -0.275000 1.44e-01
Cyclin D associated events in G1 47 1.14e-03 -0.274000 5.57e-03
G1 Phase 47 1.14e-03 -0.274000 5.57e-03
Spry regulation of FGF signaling 16 5.75e-02 -0.274000 1.45e-01
Uptake and actions of bacterial toxins 25 1.77e-02 -0.274000 5.99e-02
Cellular responses to stimuli 702 6.05e-35 -0.274000 4.45e-32
Telomere Extension By Telomerase 21 3.03e-02 -0.273000 9.30e-02
Translesion Synthesis by POLH 18 4.53e-02 -0.273000 1.22e-01
Platelet Adhesion to exposed collagen 11 1.18e-01 -0.272000 2.48e-01
Gap junction trafficking 32 7.77e-03 -0.272000 2.95e-02
Mitotic G1 phase and G1/S transition 143 2.05e-08 -0.272000 2.69e-07
Polo-like kinase mediated events 14 7.83e-02 -0.272000 1.83e-01
IRAK2 mediated activation of TAK1 complex 10 1.37e-01 -0.272000 2.78e-01
Diseases associated with N-glycosylation of proteins 20 3.54e-02 -0.272000 1.05e-01
Selective autophagy 72 6.81e-05 -0.272000 4.41e-04
Transport of bile salts and organic acids, metal ions and amine compounds 46 1.44e-03 -0.272000 6.87e-03
Formation of paraxial mesoderm 63 1.98e-04 -0.271000 1.15e-03
Late SARS-CoV-2 Infection Events 66 1.44e-04 -0.271000 8.77e-04
AKT phosphorylates targets in the nucleus 10 1.39e-01 -0.270000 2.80e-01
Signaling by CSF3 (G-CSF) 29 1.18e-02 -0.270000 4.25e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 8.05e-02 -0.270000 1.87e-01
Establishment of Sister Chromatid Cohesion 11 1.22e-01 0.270000 2.52e-01
rRNA modification in the nucleus and cytosol 59 3.57e-04 -0.269000 1.94e-03
Cellular responses to stress 693 4.77e-33 -0.268000 2.34e-30
cGMP effects 13 9.54e-02 0.267000 2.14e-01
DCC mediated attractive signaling 13 9.58e-02 0.267000 2.14e-01
Peroxisomal lipid metabolism 26 1.88e-02 0.266000 6.26e-02
Signalling to RAS 20 4.05e-02 -0.265000 1.15e-01
Interleukin-1 family signaling 137 1.00e-07 -0.264000 1.15e-06
Processing of Intronless Pre-mRNAs 20 4.14e-02 0.263000 1.17e-01
Signaling by Insulin receptor 65 2.56e-04 -0.262000 1.46e-03
Signaling by the B Cell Receptor (BCR) 109 2.28e-06 -0.262000 1.81e-05
Formation of the beta-catenin:TCF transactivating complex 36 6.58e-03 -0.262000 2.55e-02
Interleukin-15 signaling 14 9.00e-02 -0.262000 2.05e-01
Regulation of TP53 Degradation 35 7.40e-03 -0.262000 2.82e-02
Alpha-protein kinase 1 signaling pathway 11 1.33e-01 -0.261000 2.73e-01
MECP2 regulates neuronal receptors and channels 15 7.98e-02 -0.261000 1.86e-01
Elevation of cytosolic Ca2+ levels 13 1.03e-01 -0.261000 2.27e-01
Peptide ligand-binding receptors 81 5.18e-05 -0.260000 3.40e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 1.55e-01 0.260000 3.05e-01
Regulation of IFNA/IFNB signaling 12 1.20e-01 -0.260000 2.49e-01
Gap junction trafficking and regulation 34 9.12e-03 -0.258000 3.40e-02
G1/S Transition 125 8.21e-07 -0.255000 7.32e-06
Initiation of Nuclear Envelope (NE) Reformation 19 5.40e-02 -0.255000 1.39e-01
Metabolism of carbohydrates 256 2.17e-12 -0.255000 6.50e-11
Nucleotide-like (purinergic) receptors 15 8.76e-02 0.255000 2.00e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 5.52e-02 0.254000 1.41e-01
CASP8 activity is inhibited 10 1.66e-01 -0.253000 3.17e-01
Dimerization of procaspase-8 10 1.66e-01 -0.253000 3.17e-01
Regulation by c-FLIP 10 1.66e-01 -0.253000 3.17e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 1.29e-01 0.253000 2.64e-01
GABA synthesis, release, reuptake and degradation 13 1.15e-01 -0.253000 2.43e-01
WNT5A-dependent internalization of FZD4 14 1.02e-01 -0.252000 2.26e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 4.73e-03 -0.252000 1.89e-02
HIV Transcription Elongation 42 4.73e-03 -0.252000 1.89e-02
Tat-mediated elongation of the HIV-1 transcript 42 4.73e-03 -0.252000 1.89e-02
NPAS4 regulates expression of target genes 18 6.55e-02 -0.251000 1.59e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 5.96e-02 -0.250000 1.48e-01
Interleukin-35 Signalling 10 1.72e-01 -0.250000 3.25e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 1.18e-02 -0.250000 4.25e-02
Degradation of the extracellular matrix 110 7.28e-06 -0.248000 5.38e-05
FRS-mediated FGFR3 signaling 14 1.10e-01 -0.247000 2.37e-01
Signaling by Interleukins 388 9.99e-17 -0.246000 4.46e-15
Carboxyterminal post-translational modifications of tubulin 30 1.97e-02 -0.246000 6.50e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 1.12e-01 0.246000 2.38e-01
p75NTR recruits signalling complexes 13 1.27e-01 -0.244000 2.62e-01
Peptide hormone metabolism 51 2.57e-03 -0.244000 1.12e-02
Cytochrome c-mediated apoptotic response 13 1.28e-01 0.244000 2.63e-01
Surfactant metabolism 19 6.69e-02 0.243000 1.62e-01
Signaling by NOTCH4 81 1.60e-04 -0.243000 9.61e-04
Interleukin-12 family signaling 47 4.12e-03 -0.242000 1.69e-02
Glucose metabolism 82 1.55e-04 -0.242000 9.32e-04
Chaperonin-mediated protein folding 77 2.48e-04 -0.242000 1.43e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 1.18e-01 -0.241000 2.48e-01
Defective EXT2 causes exostoses 2 14 1.18e-01 -0.241000 2.48e-01
Mismatch Repair 14 1.18e-01 -0.241000 2.48e-01
Purine catabolism 13 1.32e-01 -0.241000 2.71e-01
Base-Excision Repair, AP Site Formation 22 5.07e-02 -0.241000 1.34e-01
Fc epsilon receptor (FCERI) signaling 131 2.04e-06 -0.240000 1.64e-05
Formation of RNA Pol II elongation complex 56 1.92e-03 -0.240000 8.85e-03
RNA Polymerase II Transcription Elongation 56 1.92e-03 -0.240000 8.85e-03
Transcriptional regulation by RUNX1 164 1.41e-07 -0.238000 1.56e-06
Metalloprotease DUBs 19 7.20e-02 -0.238000 1.73e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 4.81e-02 -0.238000 1.29e-01
Metabolism of nucleotides 82 1.97e-04 -0.238000 1.15e-03
Nitric oxide stimulates guanylate cyclase 16 1.00e-01 0.237000 2.22e-01
Classical antibody-mediated complement activation 13 1.40e-01 -0.237000 2.81e-01
Molecules associated with elastic fibres 33 1.91e-02 -0.236000 6.35e-02
Receptor Mediated Mitophagy 11 1.77e-01 -0.235000 3.30e-01
Role of phospholipids in phagocytosis 30 2.59e-02 -0.235000 8.11e-02
Platelet sensitization by LDL 17 9.39e-02 -0.235000 2.11e-01
CLEC7A (Dectin-1) induces NFAT activation 11 1.78e-01 -0.234000 3.31e-01
Platelet calcium homeostasis 22 5.78e-02 -0.234000 1.46e-01
Signaling by FGFR2 in disease 34 1.84e-02 -0.234000 6.19e-02
ABC-family proteins mediated transport 92 1.14e-04 -0.233000 7.04e-04
Amino acids regulate mTORC1 50 4.42e-03 -0.233000 1.79e-02
Signaling by Hedgehog 140 2.10e-06 -0.232000 1.68e-05
Detoxification of Reactive Oxygen Species 33 2.10e-02 -0.232000 6.77e-02
Signaling by FGFR4 in disease 10 2.04e-01 0.232000 3.65e-01
Formation of the Early Elongation Complex 33 2.12e-02 -0.232000 6.80e-02
Formation of the HIV-1 Early Elongation Complex 33 2.12e-02 -0.232000 6.80e-02
Synthesis of DNA 116 1.64e-05 -0.232000 1.14e-04
Uptake and function of anthrax toxins 11 1.84e-01 -0.231000 3.38e-01
DNA Replication 127 6.80e-06 -0.231000 5.08e-05
SHC-mediated cascade:FGFR1 13 1.49e-01 -0.231000 2.96e-01
MET activates PTK2 signaling 30 2.96e-02 -0.230000 9.11e-02
RORA activates gene expression 18 9.23e-02 0.229000 2.09e-01
Gastrulation 86 2.44e-04 -0.229000 1.41e-03
FRS-mediated FGFR2 signaling 16 1.14e-01 -0.228000 2.42e-01
Cell surface interactions at the vascular wall 111 3.32e-05 -0.228000 2.24e-04
Synthesis of PIPs at the Golgi membrane 15 1.27e-01 0.228000 2.62e-01
Antigen processing-Cross presentation 92 1.64e-04 -0.227000 9.79e-04
Cholesterol biosynthesis 26 4.47e-02 -0.227000 1.22e-01
Regulation of TP53 Activity through Acetylation 29 3.41e-02 -0.227000 1.02e-01
PI-3K cascade:FGFR3 12 1.73e-01 -0.227000 3.26e-01
Association of TriC/CCT with target proteins during biosynthesis 35 2.01e-02 -0.227000 6.56e-02
PIWI-interacting RNA (piRNA) biogenesis 22 6.52e-02 -0.227000 1.59e-01
G2/M Checkpoints 124 1.30e-05 -0.227000 9.27e-05
Attachment and Entry 9694614 16 1.17e-01 -0.227000 2.46e-01
TAK1-dependent IKK and NF-kappa-B activation 43 1.02e-02 -0.226000 3.73e-02
Pyruvate metabolism 27 4.26e-02 -0.226000 1.18e-01
Nucleotide biosynthesis 12 1.76e-01 -0.225000 3.30e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 4.26e-02 -0.225000 1.18e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.26e-02 -0.225000 1.18e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 42 1.16e-02 -0.225000 4.20e-02
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 1.20e-01 0.225000 2.49e-01
Incretin synthesis, secretion, and inactivation 12 1.78e-01 -0.225000 3.31e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 12 1.78e-01 -0.225000 3.31e-01
Signaling by FGFR3 34 2.34e-02 -0.225000 7.44e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 1.61e-01 -0.225000 3.11e-01
DNA Double Strand Break Response 43 1.09e-02 -0.224000 3.97e-02
Regulation of CDH11 gene transcription 10 2.20e-01 -0.224000 3.83e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 1.10e-01 -0.224000 2.37e-01
Leading Strand Synthesis 14 1.47e-01 0.224000 2.92e-01
Polymerase switching 14 1.47e-01 0.224000 2.92e-01
Expression and translocation of olfactory receptors 21 7.57e-02 0.224000 1.79e-01
PTEN Regulation 137 6.38e-06 -0.224000 4.78e-05
Protein folding 83 4.37e-04 -0.223000 2.34e-03
VEGFR2 mediated cell proliferation 19 9.36e-02 -0.222000 2.11e-01
Nuclear Events (kinase and transcription factor activation) 57 3.80e-03 -0.222000 1.57e-02
RIP-mediated NFkB activation via ZBP1 17 1.14e-01 -0.221000 2.42e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 5.11e-02 -0.221000 1.35e-01
Kinesins 47 9.04e-03 -0.220000 3.38e-02
Platelet degranulation 110 6.96e-05 -0.220000 4.45e-04
FGFR2 alternative splicing 24 6.28e-02 -0.219000 1.55e-01
Axon guidance 487 1.38e-16 -0.219000 5.96e-15
Nervous system development 507 3.46e-17 -0.219000 1.59e-15
Downregulation of TGF-beta receptor signaling 26 5.37e-02 -0.219000 1.39e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 1.22e-02 -0.219000 4.36e-02
Cleavage of the damaged pyrimidine 20 9.09e-02 -0.218000 2.06e-01
Depyrimidination 20 9.09e-02 -0.218000 2.06e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 20 9.09e-02 -0.218000 2.06e-01
RNA Polymerase III Chain Elongation 18 1.10e-01 -0.218000 2.37e-01
Formation of the cornified envelope 23 7.07e-02 -0.218000 1.70e-01
Keratinization 23 7.07e-02 -0.218000 1.70e-01
Signaling by PDGFRA extracellular domain mutants 12 1.92e-01 -0.218000 3.49e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.92e-01 -0.218000 3.49e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 2.34e-01 -0.217000 4.02e-01
Nuclear Envelope (NE) Reassembly 68 1.96e-03 -0.217000 8.96e-03
Glycogen metabolism 23 7.35e-02 -0.216000 1.75e-01
Translesion synthesis by REV1 16 1.36e-01 -0.215000 2.78e-01
RA biosynthesis pathway 16 1.37e-01 0.215000 2.78e-01
Nuclear events stimulated by ALK signaling in cancer 19 1.05e-01 -0.215000 2.30e-01
Activation of BAD and translocation to mitochondria 15 1.50e-01 -0.215000 2.97e-01
SARS-CoV-1-host interactions 94 3.28e-04 -0.214000 1.82e-03
Viral Infection Pathways 662 1.14e-20 -0.213000 1.12e-18
Bacterial Infection Pathways 65 3.00e-03 -0.213000 1.30e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 3.47e-02 0.212000 1.03e-01
TRP channels 20 1.00e-01 0.212000 2.22e-01
Signaling by FGFR2 61 4.18e-03 -0.212000 1.71e-02
Response to elevated platelet cytosolic Ca2+ 114 9.32e-05 -0.212000 5.86e-04
RNA Polymerase II Pre-transcription Events 77 1.35e-03 -0.211000 6.49e-03
Mitotic G2-G2/M phases 187 6.56e-07 -0.211000 6.10e-06
C-type lectin receptors (CLRs) 122 5.76e-05 -0.211000 3.77e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 2.26e-01 -0.211000 3.92e-01
G-protein beta:gamma signalling 27 5.87e-02 0.210000 1.47e-01
MHC class II antigen presentation 97 3.53e-04 -0.210000 1.94e-03
G2/M Transition 185 9.19e-07 -0.209000 7.95e-06
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 1.91e-01 -0.209000 3.49e-01
PI-3K cascade:FGFR2 14 1.76e-01 -0.209000 3.29e-01
HIV Infection 223 8.01e-08 -0.209000 9.43e-07
TGF-beta receptor signaling activates SMADs 45 1.58e-02 -0.208000 5.43e-02
activated TAK1 mediates p38 MAPK activation 23 8.44e-02 -0.208000 1.94e-01
Separation of Sister Chromatids 175 2.24e-06 -0.208000 1.78e-05
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 1.96e-01 -0.207000 3.53e-01
Regulation of TNFR1 signaling 48 1.32e-02 -0.207000 4.70e-02
Metabolism of proteins 1630 3.72e-43 -0.207000 5.48e-40
PERK regulates gene expression 32 4.36e-02 -0.206000 1.20e-01
Signaling by FGFR4 32 4.36e-02 -0.206000 1.20e-01
Acyl chain remodelling of PE 17 1.42e-01 0.206000 2.85e-01
Metabolism of fat-soluble vitamins 32 4.43e-02 -0.205000 1.21e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 2.39e-01 -0.205000 4.08e-01
NRIF signals cell death from the nucleus 16 1.57e-01 -0.205000 3.07e-01
Neutrophil degranulation 423 6.57e-13 -0.204000 2.10e-11
Glycolysis 65 4.46e-03 -0.204000 1.80e-02
Negative regulation of FGFR1 signaling 25 7.79e-02 -0.204000 1.83e-01
RAF-independent MAPK1/3 activation 22 9.82e-02 -0.204000 2.18e-01
Processive synthesis on the C-strand of the telomere 19 1.24e-01 -0.204000 2.57e-01
TNFR1-induced NF-kappa-B signaling pathway 33 4.40e-02 -0.203000 1.20e-01
Host Interactions of HIV factors 127 8.21e-05 -0.202000 5.23e-04
TRAF3-dependent IRF activation pathway 13 2.07e-01 0.202000 3.67e-01
Activation of BH3-only proteins 28 6.45e-02 -0.202000 1.58e-01
Synthesis of PIPs at the late endosome membrane 11 2.46e-01 0.202000 4.20e-01
TNFR1-induced proapoptotic signaling 25 8.09e-02 -0.202000 1.88e-01
Regulation of Complement cascade 37 3.38e-02 -0.202000 1.01e-01
Protein localization 155 1.51e-05 -0.202000 1.07e-04
Recycling pathway of L1 41 2.57e-02 -0.201000 8.08e-02
Creation of C4 and C2 activators 16 1.64e-01 -0.201000 3.15e-01
FRS-mediated FGFR4 signaling 13 2.09e-01 -0.201000 3.70e-01
DNA Damage Recognition in GG-NER 38 3.20e-02 -0.201000 9.68e-02
Purine salvage 12 2.28e-01 -0.201000 3.93e-01
ER Quality Control Compartment (ERQC) 21 1.11e-01 -0.201000 2.38e-01
Regulation of CDH11 function 10 2.71e-01 -0.201000 4.52e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 1.78e-01 -0.201000 3.31e-01
Signaling by FGFR 70 3.72e-03 -0.201000 1.54e-02
Synthesis of substrates in N-glycan biosythesis 58 8.30e-03 -0.200000 3.12e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 1.68e-01 0.199000 3.20e-01
Plasma lipoprotein assembly 11 2.52e-01 0.199000 4.28e-01
Citric acid cycle (TCA cycle) 22 1.08e-01 -0.198000 2.33e-01
Diseases of glycosylation 127 1.16e-04 -0.198000 7.17e-04
Metabolic disorders of biological oxidation enzymes 23 1.01e-01 -0.198000 2.23e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 3.58e-03 -0.197000 1.49e-02
TNFs bind their physiological receptors 19 1.37e-01 -0.197000 2.79e-01
mRNA Splicing - Minor Pathway 50 1.64e-02 -0.196000 5.63e-02
Mitotic Anaphase 218 6.60e-07 -0.196000 6.10e-06
Oxidative Stress Induced Senescence 69 4.96e-03 -0.196000 1.97e-02
Autophagy 139 6.95e-05 -0.196000 4.45e-04
Transcription of the HIV genome 67 5.69e-03 -0.195000 2.23e-02
SARS-CoV-1 Infection 136 8.59e-05 -0.195000 5.44e-04
RHOBTB1 GTPase cycle 23 1.06e-01 0.195000 2.30e-01
RMTs methylate histone arginines 33 5.26e-02 -0.195000 1.38e-01
RAF/MAP kinase cascade 234 3.07e-07 -0.195000 3.05e-06
TP53 Regulates Transcription of DNA Repair Genes 61 8.65e-03 -0.194000 3.24e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 29 7.08e-02 -0.194000 1.70e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 1.67e-01 -0.194000 3.19e-01
MET receptor recycling 10 2.89e-01 0.194000 4.71e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 186 5.60e-06 -0.193000 4.22e-05
Diseases of carbohydrate metabolism 28 7.69e-02 -0.193000 1.81e-01
Receptor-type tyrosine-protein phosphatases 12 2.48e-01 -0.193000 4.22e-01
Mitotic Metaphase and Anaphase 219 9.14e-07 -0.193000 7.95e-06
Pre-NOTCH Processing in Golgi 18 1.57e-01 -0.192000 3.08e-01
Toll Like Receptor 3 (TLR3) Cascade 103 7.54e-04 -0.192000 3.87e-03
mRNA Capping 29 7.37e-02 -0.192000 1.75e-01
Adenylate cyclase activating pathway 10 2.94e-01 0.192000 4.76e-01
Interleukin-12 signaling 41 3.38e-02 -0.192000 1.01e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 1.85e-01 0.192000 3.38e-01
NS1 Mediated Effects on Host Pathways 40 3.69e-02 0.191000 1.07e-01
MAPK1/MAPK3 signaling 240 3.97e-07 -0.190000 3.79e-06
Regulation of IFNG signaling 13 2.36e-01 -0.190000 4.06e-01
Regulation of PTEN mRNA translation 11 2.76e-01 0.190000 4.57e-01
Formation of WDR5-containing histone-modifying complexes 42 3.34e-02 0.190000 1.01e-01
Infectious disease 836 1.88e-20 -0.190000 1.63e-18
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 95 1.42e-03 -0.189000 6.81e-03
O-linked glycosylation of mucins 42 3.37e-02 -0.189000 1.01e-01
Transcriptional regulation of granulopoiesis 33 6.00e-02 -0.189000 1.49e-01
Beta-catenin independent WNT signaling 133 1.86e-04 -0.188000 1.10e-03
Chaperone Mediated Autophagy 20 1.47e-01 -0.188000 2.92e-01
Retrograde neurotrophin signalling 14 2.27e-01 -0.187000 3.93e-01
Amyloid fiber formation 41 3.90e-02 -0.186000 1.11e-01
Amino acid transport across the plasma membrane 20 1.50e-01 -0.186000 2.97e-01
PIP3 activates AKT signaling 242 6.70e-07 -0.186000 6.12e-06
Ion homeostasis 43 3.52e-02 -0.186000 1.04e-01
Glycosphingolipid metabolism 36 5.50e-02 -0.185000 1.41e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 2.90e-01 -0.184000 4.72e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 40 4.41e-02 -0.184000 1.21e-01
Apoptotic cleavage of cellular proteins 34 6.35e-02 0.184000 1.56e-01
Signaling by WNT 242 9.14e-07 -0.183000 7.95e-06
DNA methylation 10 3.19e-01 -0.182000 5.04e-01
Metabolism of cofactors 18 1.82e-01 -0.182000 3.37e-01
Signaling by PDGF 53 2.22e-02 -0.182000 7.10e-02
Azathioprine ADME 18 1.83e-01 -0.181000 3.37e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 22 1.41e-01 -0.181000 2.83e-01
Signaling by NTRK1 (TRKA) 108 1.19e-03 -0.181000 5.80e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 2.27e-01 0.180000 3.93e-01
Pregnenolone biosynthesis 10 3.25e-01 -0.180000 5.09e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 1.38e-01 -0.179000 2.80e-01
Binding and Uptake of Ligands by Scavenger Receptors 38 5.75e-02 -0.178000 1.45e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 11 3.07e-01 -0.178000 4.91e-01
DNA Damage/Telomere Stress Induced Senescence 33 7.76e-02 -0.178000 1.82e-01
Mitotic Telophase/Cytokinesis 13 2.71e-01 0.176000 4.52e-01
Post-translational modification: synthesis of GPI-anchored proteins 62 1.65e-02 -0.176000 5.63e-02
NR1H2 and NR1H3-mediated signaling 40 5.48e-02 0.176000 1.41e-01
Regulation of RUNX1 Expression and Activity 18 1.98e-01 -0.175000 3.55e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 1.55e-01 -0.175000 3.05e-01
HIV Transcription Initiation 45 4.21e-02 -0.175000 1.17e-01
RNA Polymerase II HIV Promoter Escape 45 4.21e-02 -0.175000 1.17e-01
RNA Polymerase II Promoter Escape 45 4.21e-02 -0.175000 1.17e-01
RNA Polymerase II Transcription Initiation 45 4.21e-02 -0.175000 1.17e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 4.21e-02 -0.175000 1.17e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 4.21e-02 -0.175000 1.17e-01
Metabolism of folate and pterines 16 2.25e-01 -0.175000 3.92e-01
Macroautophagy 125 7.32e-04 -0.175000 3.78e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 1.56e-01 -0.175000 3.06e-01
Deactivation of the beta-catenin transactivating complex 39 5.88e-02 -0.175000 1.47e-01
Regulation of FZD by ubiquitination 16 2.26e-01 -0.175000 3.92e-01
RUNX2 regulates osteoblast differentiation 22 1.56e-01 -0.175000 3.06e-01
Repression of WNT target genes 14 2.58e-01 -0.175000 4.35e-01
Costimulation by the CD28 family 53 2.81e-02 -0.174000 8.75e-02
S Phase 157 1.66e-04 -0.174000 9.89e-04
Cytokine Signaling in Immune system 593 5.64e-13 -0.174000 1.85e-11
PI Metabolism 78 8.00e-03 0.174000 3.02e-02
Oncogene Induced Senescence 33 8.44e-02 -0.174000 1.94e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 8.96e-02 -0.173000 2.04e-01
Neddylation 223 8.36e-06 -0.173000 6.09e-05
Glutamate Neurotransmitter Release Cycle 22 1.61e-01 -0.173000 3.11e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 7.33e-02 -0.173000 1.75e-01
Paracetamol ADME 19 1.93e-01 0.172000 3.50e-01
RUNX3 regulates NOTCH signaling 14 2.64e-01 0.172000 4.44e-01
Transcription of E2F targets under negative control by DREAM complex 18 2.06e-01 -0.172000 3.65e-01
Translesion synthesis by POLK 17 2.19e-01 -0.172000 3.82e-01
Inflammasomes 21 1.72e-01 -0.172000 3.25e-01
PI-3K cascade:FGFR4 11 3.24e-01 -0.172000 5.09e-01
TRAF6 mediated IRF7 activation 15 2.51e-01 0.171000 4.26e-01
Telomere Maintenance 69 1.40e-02 -0.171000 4.94e-02
Muscle contraction 154 2.54e-04 -0.171000 1.45e-03
MyD88-independent TLR4 cascade 107 2.31e-03 -0.171000 1.03e-02
TRIF(TICAM1)-mediated TLR4 signaling 107 2.31e-03 -0.171000 1.03e-02
Retinoid metabolism and transport 29 1.12e-01 -0.171000 2.39e-01
Removal of the Flap Intermediate from the C-strand 17 2.24e-01 -0.170000 3.90e-01
The NLRP3 inflammasome 16 2.38e-01 -0.170000 4.08e-01
Diseases of metabolism 206 2.99e-05 -0.169000 2.04e-04
Blood group systems biosynthesis 13 2.92e-01 -0.169000 4.75e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.03e-01 -0.169000 3.64e-01
Cellular Senescence 132 8.43e-04 -0.168000 4.25e-03
MAPK family signaling cascades 275 1.61e-06 -0.168000 1.31e-05
Defects in cobalamin (B12) metabolism 12 3.13e-01 0.168000 4.96e-01
RAB geranylgeranylation 56 2.96e-02 -0.168000 9.11e-02
Formation of Fibrin Clot (Clotting Cascade) 20 1.93e-01 -0.168000 3.50e-01
Disorders of Developmental Biology 11 3.35e-01 -0.168000 5.18e-01
Disorders of Nervous System Development 11 3.35e-01 -0.168000 5.18e-01
Loss of function of MECP2 in Rett syndrome 11 3.35e-01 -0.168000 5.18e-01
Pervasive developmental disorders 11 3.35e-01 -0.168000 5.18e-01
Apoptosis 161 2.39e-04 -0.168000 1.38e-03
ZBP1(DAI) mediated induction of type I IFNs 20 1.94e-01 -0.168000 3.50e-01
Meiotic recombination 26 1.39e-01 -0.168000 2.80e-01
G alpha (i) signalling events 181 1.04e-04 -0.167000 6.53e-04
Intracellular signaling by second messengers 279 1.58e-06 -0.167000 1.30e-05
Complement cascade 41 6.39e-02 -0.167000 1.57e-01
Downstream signaling of activated FGFR3 19 2.08e-01 -0.167000 3.67e-01
Transport of the SLBP independent Mature mRNA 35 8.74e-02 0.167000 2.00e-01
Developmental Biology 780 3.08e-15 -0.167000 1.16e-13
Factors involved in megakaryocyte development and platelet production 120 1.62e-03 -0.167000 7.57e-03
RAF activation 34 9.26e-02 -0.167000 2.09e-01
Integration of energy metabolism 87 7.29e-03 -0.167000 2.79e-02
Apoptotic execution phase 42 6.24e-02 0.166000 1.54e-01
G beta:gamma signalling through PLC beta 15 2.66e-01 0.166000 4.46e-01
Fatty acyl-CoA biosynthesis 30 1.16e-01 -0.166000 2.44e-01
Potential therapeutics for SARS 96 4.98e-03 -0.166000 1.97e-02
IGF1R signaling cascade 39 7.42e-02 -0.165000 1.76e-01
Disorders of transmembrane transporters 139 7.82e-04 -0.165000 3.99e-03
Innate Immune System 870 3.20e-16 -0.164000 1.34e-14
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 8.93e-02 -0.164000 2.04e-01
HCMV Infection 99 4.92e-03 -0.164000 1.96e-02
GPER1 signaling 38 8.17e-02 -0.163000 1.89e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 1.11e-01 0.163000 2.38e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.11e-01 0.163000 2.38e-01
RUNX2 regulates bone development 28 1.37e-01 -0.163000 2.78e-01
Hemostasis 488 1.10e-09 -0.162000 2.12e-08
PI3K Cascade 31 1.21e-01 -0.161000 2.52e-01
Downstream signaling of activated FGFR2 21 2.03e-01 -0.161000 3.63e-01
Other interleukin signaling 20 2.14e-01 -0.161000 3.76e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 7.26e-02 0.160000 1.74e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 4.82e-02 -0.160000 1.29e-01
Post-translational protein modification 1192 2.93e-20 -0.160000 2.27e-18
L1CAM interactions 102 5.35e-03 -0.160000 2.10e-02
Diseases of programmed cell death 47 5.94e-02 -0.159000 1.48e-01
Signaling by NOTCH 176 2.84e-04 -0.159000 1.60e-03
Signaling by ALK fusions and activated point mutants 55 4.19e-02 -0.159000 1.17e-01
Signaling by ALK in cancer 55 4.19e-02 -0.159000 1.17e-01
GAB1 signalosome 14 3.05e-01 0.158000 4.88e-01
Ub-specific processing proteases 156 6.51e-04 -0.158000 3.39e-03
PKMTs methylate histone lysines 42 7.62e-02 0.158000 1.79e-01
Mitochondrial tRNA aminoacylation 21 2.10e-01 -0.158000 3.70e-01
Protein methylation 15 2.90e-01 -0.158000 4.72e-01
RHOV GTPase cycle 34 1.13e-01 0.157000 2.40e-01
Olfactory Signaling Pathway 25 1.74e-01 0.157000 3.28e-01
Synaptic adhesion-like molecules 18 2.49e-01 -0.157000 4.23e-01
APC-Cdc20 mediated degradation of Nek2A 25 1.75e-01 -0.157000 3.28e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 24 1.85e-01 -0.156000 3.38e-01
Trafficking of AMPA receptors 24 1.85e-01 -0.156000 3.38e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.08e-01 -0.155000 2.33e-01
STING mediated induction of host immune responses 15 3.01e-01 0.154000 4.84e-01
p38MAPK events 13 3.37e-01 -0.154000 5.19e-01
Base Excision Repair 50 5.99e-02 -0.154000 1.49e-01
Signaling by WNT in cancer 28 1.59e-01 -0.154000 3.09e-01
RIPK1-mediated regulated necrosis 30 1.45e-01 -0.154000 2.91e-01
Regulation of necroptotic cell death 30 1.45e-01 -0.154000 2.91e-01
HS-GAG biosynthesis 25 1.84e-01 -0.153000 3.38e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 3.04e-01 -0.153000 4.86e-01
Formation of apoptosome 11 3.79e-01 0.153000 5.71e-01
Regulation of the apoptosome activity 11 3.79e-01 0.153000 5.71e-01
Trafficking of GluR2-containing AMPA receptors 14 3.22e-01 -0.153000 5.06e-01
Sema4D induced cell migration and growth-cone collapse 19 2.53e-01 -0.152000 4.28e-01
Neurexins and neuroligins 41 9.32e-02 -0.152000 2.10e-01
Signaling by FGFR1 40 9.75e-02 -0.151000 2.17e-01
Platelet Aggregation (Plug Formation) 30 1.51e-01 -0.151000 2.99e-01
Programmed Cell Death 188 3.54e-04 -0.151000 1.94e-03
Protein-protein interactions at synapses 63 3.86e-02 -0.151000 1.11e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.92e-01 -0.151000 3.49e-01
Diseases of mitotic cell cycle 38 1.08e-01 -0.151000 2.34e-01
Interleukin-20 family signaling 14 3.30e-01 -0.151000 5.14e-01
Notch-HLH transcription pathway 28 1.68e-01 0.150000 3.20e-01
Metabolism 1733 8.66e-25 -0.150000 2.55e-22
Signaling by FGFR3 in disease 16 3.00e-01 -0.150000 4.82e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 2.05e-01 -0.149000 3.65e-01
Immune System 1632 2.65e-23 -0.149000 6.49e-21
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 3.91e-01 0.149000 5.83e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 5.56e-02 -0.149000 1.42e-01
Initial triggering of complement 23 2.16e-01 -0.149000 3.78e-01
Late Phase of HIV Life Cycle 132 3.16e-03 -0.149000 1.34e-02
Growth hormone receptor signaling 20 2.50e-01 -0.148000 4.25e-01
Transport of the SLBP Dependant Mature mRNA 36 1.27e-01 0.147000 2.61e-01
MET promotes cell motility 40 1.09e-01 -0.146000 2.36e-01
IRS-related events triggered by IGF1R 38 1.19e-01 -0.146000 2.49e-01
Disease 1475 1.73e-20 -0.146000 1.59e-18
Cell Cycle Checkpoints 239 1.07e-04 -0.146000 6.67e-04
Condensation of Prometaphase Chromosomes 11 4.05e-01 -0.145000 5.97e-01
Translesion synthesis by POLI 17 3.02e-01 -0.145000 4.84e-01
Vpr-mediated nuclear import of PICs 34 1.46e-01 0.144000 2.91e-01
HIV Life Cycle 145 2.74e-03 -0.144000 1.19e-02
Acyl chain remodelling of PS 12 3.87e-01 0.144000 5.80e-01
Signaling by FGFR in disease 53 7.01e-02 -0.144000 1.69e-01
Metabolism of RNA 693 1.35e-10 -0.144000 3.42e-09
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.03e-01 0.144000 2.27e-01
The phototransduction cascade 19 2.79e-01 -0.144000 4.60e-01
TNF signaling 57 6.10e-02 -0.143000 1.51e-01
MyD88 cascade initiated on plasma membrane 94 1.66e-02 -0.143000 5.65e-02
Toll Like Receptor 10 (TLR10) Cascade 94 1.66e-02 -0.143000 5.65e-02
Toll Like Receptor 5 (TLR5) Cascade 94 1.66e-02 -0.143000 5.65e-02
ATF4 activates genes in response to endoplasmic reticulum stress 27 2.01e-01 -0.142000 3.59e-01
Formation of annular gap junctions 11 4.14e-01 -0.142000 6.06e-01
Cytoprotection by HMOX1 58 6.20e-02 -0.142000 1.53e-01
Regulation of TP53 Activity through Methylation 19 2.86e-01 -0.141000 4.69e-01
Beta-oxidation of very long chain fatty acids 10 4.40e-01 0.141000 6.32e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.96e-01 -0.141000 3.53e-01
Signaling by NTRKs 124 6.75e-03 -0.141000 2.61e-02
Dissolution of Fibrin Clot 10 4.40e-01 -0.141000 6.32e-01
Regulation of TP53 Activity 149 3.09e-03 -0.141000 1.32e-02
Cytosolic sensors of pathogen-associated DNA 63 5.41e-02 -0.140000 1.39e-01
Negative regulation of FLT3 13 3.83e-01 -0.140000 5.75e-01
SLC-mediated transmembrane transport 152 3.04e-03 -0.139000 1.31e-02
GRB2 events in EGFR signaling 10 4.46e-01 0.139000 6.39e-01
Bile acid and bile salt metabolism 29 1.95e-01 0.139000 3.52e-01
NCAM1 interactions 32 1.74e-01 -0.139000 3.28e-01
PI3K/AKT Signaling in Cancer 83 2.90e-02 -0.139000 8.97e-02
Signaling by NTRK3 (TRKC) 17 3.23e-01 -0.139000 5.07e-01
Rap1 signalling 13 3.88e-01 0.138000 5.80e-01
Platelet activation, signaling and aggregation 222 4.03e-04 -0.138000 2.17e-03
Regulation of NF-kappa B signaling 18 3.12e-01 -0.138000 4.96e-01
Signaling by KIT in disease 20 2.89e-01 -0.137000 4.71e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 2.89e-01 -0.137000 4.71e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.33e-01 0.137000 6.25e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.44e-02 -0.136000 5.03e-02
Toll Like Receptor 2 (TLR2) Cascade 108 1.44e-02 -0.136000 5.03e-02
Toll Like Receptor TLR1:TLR2 Cascade 108 1.44e-02 -0.136000 5.03e-02
Toll Like Receptor TLR6:TLR2 Cascade 108 1.44e-02 -0.136000 5.03e-02
Sialic acid metabolism 28 2.12e-01 -0.136000 3.74e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.59e-01 0.136000 3.09e-01
Transcriptional Regulation by TP53 340 1.78e-05 -0.136000 1.23e-04
Inactivation, recovery and regulation of the phototransduction cascade 18 3.20e-01 -0.135000 5.04e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.78e-01 0.135000 3.31e-01
Regulation of actin dynamics for phagocytic cup formation 67 5.57e-02 -0.135000 1.42e-01
Signaling by NODAL 13 4.00e-01 0.135000 5.93e-01
FOXO-mediated transcription of cell death genes 15 3.67e-01 -0.135000 5.58e-01
Defective pyroptosis 19 3.10e-01 0.135000 4.94e-01
Basigin interactions 21 2.88e-01 -0.134000 4.71e-01
MAP kinase activation 63 6.76e-02 -0.133000 1.63e-01
Signaling by Receptor Tyrosine Kinases 469 8.53e-07 -0.133000 7.56e-06
Inwardly rectifying K+ channels 22 2.81e-01 -0.133000 4.64e-01
Regulation of PTEN gene transcription 59 7.81e-02 -0.133000 1.83e-01
Class A/1 (Rhodopsin-like receptors) 146 5.73e-03 -0.133000 2.23e-02
Methylation 12 4.27e-01 -0.132000 6.19e-01
SARS-CoV Infections 379 1.04e-05 -0.132000 7.49e-05
Trafficking and processing of endosomal TLR 12 4.30e-01 0.132000 6.21e-01
Negative regulators of DDX58/IFIH1 signaling 34 1.85e-01 -0.132000 3.38e-01
Mitochondrial biogenesis 85 3.63e-02 -0.131000 1.06e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 82 4.04e-02 -0.131000 1.15e-01
Biosynthesis of DHA-derived SPMs 11 4.53e-01 0.131000 6.45e-01
IRS-mediated signalling 35 1.82e-01 -0.130000 3.37e-01
RHO GTPases Activate Formins 126 1.18e-02 -0.130000 4.25e-02
Heme biosynthesis 13 4.17e-01 -0.130000 6.09e-01
Role of LAT2/NTAL/LAB on calcium mobilization 20 3.14e-01 -0.130000 4.98e-01
Downstream signaling of activated FGFR4 18 3.41e-01 -0.130000 5.24e-01
Cell Cycle, Mitotic 481 1.24e-06 -0.129000 1.05e-05
Signaling by TGF-beta Receptor Complex 90 3.41e-02 -0.129000 1.02e-01
Transport of vitamins, nucleosides, and related molecules 29 2.29e-01 -0.129000 3.95e-01
Interleukin-6 signaling 11 4.59e-01 -0.129000 6.50e-01
Synthesis of PC 23 2.85e-01 -0.129000 4.68e-01
Formation of TC-NER Pre-Incision Complex 53 1.05e-01 -0.129000 2.30e-01
Interleukin-17 signaling 67 6.88e-02 -0.129000 1.66e-01
Toll Like Receptor 4 (TLR4) Cascade 137 9.56e-03 -0.128000 3.52e-02
Fcgamma receptor (FCGR) dependent phagocytosis 90 3.54e-02 -0.128000 1.05e-01
mRNA 3’-end processing 57 9.41e-02 0.128000 2.11e-01
Downstream signal transduction 28 2.41e-01 -0.128000 4.11e-01
EML4 and NUDC in mitotic spindle formation 103 2.56e-02 -0.127000 8.07e-02
Downregulation of ERBB2 signaling 27 2.54e-01 -0.127000 4.30e-01
Adaptive Immune System 654 4.49e-08 -0.126000 5.50e-07
Transport of small molecules 530 7.97e-07 -0.126000 7.15e-06
Heparan sulfate/heparin (HS-GAG) metabolism 45 1.46e-01 -0.125000 2.91e-01
M Phase 344 6.83e-05 -0.125000 4.41e-04
Regulated Necrosis 51 1.23e-01 -0.125000 2.55e-01
Synthesis of bile acids and bile salts 26 2.72e-01 0.124000 4.52e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 4.56e-01 0.124000 6.47e-01
Constitutive Signaling by EGFRvIII 15 4.04e-01 0.124000 5.97e-01
Signaling by EGFRvIII in Cancer 15 4.04e-01 0.124000 5.97e-01
Signaling by cytosolic FGFR1 fusion mutants 18 3.62e-01 0.124000 5.52e-01
Neurotransmitter release cycle 37 1.94e-01 -0.123000 3.50e-01
G beta:gamma signalling through CDC42 15 4.09e-01 0.123000 6.01e-01
MyD88 dependent cascade initiated on endosome 101 3.30e-02 -0.123000 9.95e-02
Miscellaneous transport and binding events 21 3.30e-01 -0.123000 5.14e-01
SARS-CoV-2 Infection 265 6.24e-04 -0.122000 3.25e-03
Glutamate and glutamine metabolism 11 4.83e-01 -0.122000 6.74e-01
Smooth Muscle Contraction 37 1.99e-01 -0.122000 3.58e-01
Insulin receptor signalling cascade 40 1.84e-01 -0.121000 3.38e-01
Cardiac conduction 92 4.52e-02 -0.121000 1.22e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 3.71e-02 -0.121000 1.07e-01
Antigen processing: Ubiquitination & Proteasome degradation 282 5.13e-04 -0.120000 2.69e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 2.39e-01 0.120000 4.08e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 2.39e-01 0.120000 4.08e-01
EGFR downregulation 27 2.80e-01 -0.120000 4.62e-01
Adherens junctions interactions 44 1.68e-01 -0.120000 3.20e-01
MET activates RAS signaling 11 4.90e-01 0.120000 6.80e-01
FCGR3A-mediated IL10 synthesis 44 1.68e-01 -0.120000 3.20e-01
Signaling by MET 75 7.27e-02 -0.120000 1.74e-01
HCMV Late Events 59 1.16e-01 -0.118000 2.45e-01
Hyaluronan uptake and degradation 11 4.97e-01 -0.118000 6.84e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.88e-01 -0.118000 4.71e-01
Interferon alpha/beta signaling 57 1.24e-01 -0.118000 2.57e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 4.06e-02 -0.117000 1.15e-01
Sulfur amino acid metabolism 23 3.30e-01 -0.117000 5.14e-01
Regulation of localization of FOXO transcription factors 12 4.82e-01 -0.117000 6.72e-01
Advanced glycosylation endproduct receptor signaling 12 4.82e-01 -0.117000 6.72e-01
MicroRNA (miRNA) biogenesis 24 3.20e-01 -0.117000 5.05e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 4.04e-01 -0.117000 5.97e-01
Plasma lipoprotein remodeling 20 3.66e-01 -0.117000 5.58e-01
Deubiquitination 227 2.50e-03 -0.117000 1.10e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 3.44e-01 -0.117000 5.29e-01
Chromosome Maintenance 92 5.41e-02 -0.116000 1.39e-01
Post NMDA receptor activation events 66 1.03e-01 -0.116000 2.27e-01
Cell Cycle 591 1.85e-06 -0.115000 1.51e-05
Heme signaling 44 1.88e-01 0.115000 3.43e-01
Negative regulation of the PI3K/AKT network 89 6.17e-02 -0.115000 1.52e-01
Circadian Clock 66 1.08e-01 -0.115000 2.33e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 13 4.75e-01 0.115000 6.66e-01
SUMOylation of DNA methylation proteins 16 4.30e-01 -0.114000 6.21e-01
Insulin processing 21 3.67e-01 -0.114000 5.58e-01
Eicosanoid ligand-binding receptors 14 4.64e-01 -0.113000 6.54e-01
Intrinsic Pathway for Apoptosis 52 1.59e-01 -0.113000 3.09e-01
The role of Nef in HIV-1 replication and disease pathogenesis 26 3.20e-01 -0.113000 5.04e-01
Prolactin receptor signaling 11 5.19e-01 0.112000 7.03e-01
Transcriptional regulation of pluripotent stem cells 16 4.38e-01 -0.112000 6.31e-01
Condensation of Prophase Chromosomes 19 4.03e-01 -0.111000 5.96e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.05e-01 0.111000 2.29e-01
IRAK1 recruits IKK complex 14 4.75e-01 -0.110000 6.66e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 4.75e-01 -0.110000 6.66e-01
Signaling by TGFB family members 112 4.52e-02 -0.110000 1.22e-01
Activation of the AP-1 family of transcription factors 10 5.48e-01 -0.110000 7.25e-01
Voltage gated Potassium channels 16 4.48e-01 0.110000 6.41e-01
Signaling by Leptin 10 5.51e-01 -0.109000 7.27e-01
Ovarian tumor domain proteases 35 2.66e-01 -0.109000 4.46e-01
mTORC1-mediated signalling 24 3.59e-01 -0.108000 5.48e-01
Signalling to ERKs 33 2.82e-01 -0.108000 4.65e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 1.62e-01 -0.108000 3.13e-01
ERBB2 Regulates Cell Motility 13 5.02e-01 0.108000 6.89e-01
Killing mechanisms 10 5.56e-01 -0.107000 7.29e-01
WNT5:FZD7-mediated leishmania damping 10 5.56e-01 -0.107000 7.29e-01
FCERI mediated Ca+2 mobilization 35 2.72e-01 -0.107000 4.52e-01
Nucleotide Excision Repair 110 5.25e-02 -0.107000 1.38e-01
Carnitine metabolism 13 5.06e-01 0.107000 6.92e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 3.57e-01 -0.107000 5.45e-01
Resolution of Sister Chromatid Cohesion 112 5.28e-02 -0.106000 1.38e-01
Diseases associated with O-glycosylation of proteins 55 1.74e-01 0.106000 3.28e-01
NOTCH2 intracellular domain regulates transcription 10 5.62e-01 0.106000 7.31e-01
Regulation of insulin secretion 60 1.57e-01 -0.106000 3.07e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 3.70e-01 -0.106000 5.63e-01
Activation of NMDA receptors and postsynaptic events 78 1.07e-01 -0.106000 2.33e-01
Synthesis of very long-chain fatty acyl-CoAs 18 4.41e-01 -0.105000 6.32e-01
Lysosome Vesicle Biogenesis 33 2.97e-01 -0.105000 4.80e-01
RNA Polymerase III Transcription Termination 23 3.84e-01 -0.105000 5.77e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 1.42e-01 -0.105000 2.85e-01
Signal transduction by L1 21 4.09e-01 -0.104000 6.00e-01
TP53 Regulates Transcription of Cell Death Genes 40 2.56e-01 -0.104000 4.33e-01
Diseases of signal transduction by growth factor receptors and second messengers 391 4.60e-04 -0.103000 2.45e-03
Metabolism of vitamins and cofactors 156 2.65e-02 -0.103000 8.27e-02
Vesicle-mediated transport 610 1.51e-05 -0.103000 1.07e-04
Class I MHC mediated antigen processing & presentation 343 1.15e-03 -0.102000 5.62e-03
RHOBTB GTPase Cycle 35 2.95e-01 0.102000 4.77e-01
Extension of Telomeres 49 2.17e-01 -0.102000 3.78e-01
Assembly of the ORC complex at the origin of replication 14 5.09e-01 -0.102000 6.94e-01
Transport of Mature Transcript to Cytoplasm 81 1.13e-01 0.102000 2.41e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 3.36e-01 -0.102000 5.19e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.62e-01 -0.101000 3.13e-01
SUMOylation of SUMOylation proteins 35 3.09e-01 0.099300 4.94e-01
SUMOylation of ubiquitinylation proteins 39 2.84e-01 0.099200 4.66e-01
Regulation of TP53 Activity through Phosphorylation 86 1.12e-01 -0.099200 2.39e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 5.53e-01 -0.099000 7.29e-01
SUMOylation of intracellular receptors 27 3.75e-01 0.098700 5.67e-01
Toll Like Receptor 9 (TLR9) Cascade 105 8.14e-02 -0.098500 1.89e-01
Intrinsic Pathway of Fibrin Clot Formation 12 5.55e-01 -0.098500 7.29e-01
Presynaptic function of Kainate receptors 16 4.96e-01 0.098400 6.84e-01
Termination of O-glycan biosynthesis 14 5.25e-01 -0.098200 7.05e-01
Resolution of D-Loop Structures 33 3.30e-01 0.098000 5.14e-01
Aflatoxin activation and detoxification 11 5.74e-01 -0.097900 7.43e-01
Signal Transduction 2041 1.09e-12 -0.097000 3.33e-11
TP53 Regulates Metabolic Genes 80 1.34e-01 -0.096800 2.75e-01
Transcriptional Regulation by VENTX 39 2.97e-01 -0.096500 4.80e-01
Regulation of innate immune responses to cytosolic DNA 14 5.32e-01 -0.096400 7.12e-01
RHOU GTPase cycle 39 2.99e-01 0.096100 4.82e-01
Depolymerization of the Nuclear Lamina 15 5.20e-01 -0.096000 7.03e-01
CD209 (DC-SIGN) signaling 20 4.58e-01 -0.096000 6.49e-01
Membrane Trafficking 575 9.15e-05 -0.095800 5.78e-04
RHOQ GTPase cycle 58 2.07e-01 0.095800 3.67e-01
Formation of Incision Complex in GG-NER 43 2.79e-01 -0.095500 4.60e-01
RHO GTPase Effectors 245 1.01e-02 -0.095500 3.72e-02
GPCR ligand binding 201 1.99e-02 -0.095400 6.52e-02
Early SARS-CoV-2 Infection Events 33 3.49e-01 -0.094100 5.36e-01
MAPK3 (ERK1) activation 10 6.07e-01 0.094000 7.64e-01
G0 and Early G1 25 4.16e-01 -0.094000 6.08e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 4.90e-01 0.094000 6.80e-01
Biosynthesis of specialized proresolving mediators (SPMs) 13 5.58e-01 0.093800 7.29e-01
Glutathione conjugation 29 3.82e-01 -0.093800 5.75e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 1.53e-01 -0.093500 3.03e-01
Signaling by ERBB2 ECD mutants 16 5.18e-01 0.093500 7.03e-01
HCMV Early Events 76 1.59e-01 -0.093400 3.09e-01
Constitutive Signaling by Aberrant PI3K in Cancer 56 2.27e-01 -0.093300 3.93e-01
Sensory perception of taste 16 5.19e-01 0.093200 7.03e-01
Synthesis of PIPs at the plasma membrane 50 2.59e-01 0.092300 4.36e-01
Listeria monocytogenes entry into host cells 18 4.99e-01 -0.092000 6.86e-01
Physiological factors 10 6.15e-01 -0.092000 7.70e-01
Resolution of Abasic Sites (AP sites) 38 3.28e-01 -0.091700 5.13e-01
Anti-inflammatory response favouring Leishmania parasite infection 75 1.72e-01 -0.091300 3.25e-01
Leishmania parasite growth and survival 75 1.72e-01 -0.091300 3.25e-01
Activation of gene expression by SREBF (SREBP) 42 3.11e-01 -0.090300 4.96e-01
G alpha (z) signalling events 38 3.38e-01 -0.089800 5.21e-01
Processing of DNA double-strand break ends 60 2.30e-01 -0.089600 3.96e-01
TP53 Regulates Transcription of Cell Cycle Genes 44 3.05e-01 -0.089400 4.88e-01
Signaling by FLT3 ITD and TKD mutants 15 5.50e-01 -0.089200 7.27e-01
HDACs deacetylate histones 36 3.55e-01 -0.089100 5.44e-01
SUMOylation of DNA damage response and repair proteins 77 1.77e-01 0.089000 3.30e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 6.10e-01 -0.088900 7.66e-01
alpha-linolenic acid (ALA) metabolism 11 6.10e-01 -0.088900 7.66e-01
FCGR3A-mediated phagocytosis 65 2.16e-01 -0.088800 3.78e-01
Leishmania phagocytosis 65 2.16e-01 -0.088800 3.78e-01
Parasite infection 65 2.16e-01 -0.088800 3.78e-01
Activation of G protein gated Potassium channels 19 5.04e-01 -0.088500 6.90e-01
G protein gated Potassium channels 19 5.04e-01 -0.088500 6.90e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 5.04e-01 -0.088500 6.90e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.28e-01 0.088400 7.75e-01
O-linked glycosylation 86 1.58e-01 -0.088100 3.09e-01
G beta:gamma signalling through PI3Kgamma 20 4.96e-01 0.088000 6.84e-01
SHC1 events in ERBB4 signaling 12 5.98e-01 -0.088000 7.62e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 4.38e-01 0.087900 6.31e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 5.59e-01 0.087100 7.29e-01
DNA strand elongation 31 4.02e-01 -0.087000 5.96e-01
Signaling by Erythropoietin 24 4.61e-01 0.087000 6.51e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 4.53e-01 -0.086800 6.45e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 3.98e-01 0.086300 5.92e-01
Rev-mediated nuclear export of HIV RNA 35 3.78e-01 0.086200 5.71e-01
RNA Polymerase III Transcription Initiation 36 3.72e-01 -0.085900 5.65e-01
Sema4D in semaphorin signaling 23 4.76e-01 -0.085900 6.66e-01
RHOG GTPase cycle 71 2.12e-01 -0.085800 3.73e-01
Cellular hexose transport 13 5.92e-01 -0.085800 7.60e-01
G beta:gamma signalling through BTK 13 5.93e-01 0.085700 7.60e-01
eNOS activation 11 6.24e-01 0.085400 7.75e-01
ERBB2 Activates PTK6 Signaling 11 6.24e-01 0.085200 7.75e-01
Death Receptor Signaling 147 7.60e-02 -0.084900 1.79e-01
Activation of SMO 16 5.58e-01 -0.084700 7.29e-01
Cytosolic sulfonation of small molecules 19 5.26e-01 -0.084100 7.06e-01
RHO GTPases activate PAKs 20 5.17e-01 -0.083800 7.03e-01
PKA activation in glucagon signalling 16 5.62e-01 -0.083800 7.31e-01
Interactions of Vpr with host cellular proteins 37 3.78e-01 0.083800 5.71e-01
SARS-CoV-2-host interactions 176 5.58e-02 -0.083700 1.42e-01
CRMPs in Sema3A signaling 15 5.76e-01 -0.083500 7.45e-01
Pyroptosis 21 5.08e-01 -0.083400 6.94e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.88e-01 -0.083200 3.43e-01
RND2 GTPase cycle 36 3.89e-01 0.082900 5.82e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 5.78e-01 -0.082900 7.46e-01
RND3 GTPase cycle 36 3.91e-01 0.082600 5.83e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 4.29e-01 -0.082100 6.21e-01
Impaired BRCA2 binding to PALB2 23 4.96e-01 0.082100 6.84e-01
Signaling by FLT3 fusion proteins 19 5.36e-01 0.082000 7.14e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 5.97e-01 -0.081600 7.62e-01
Sensory processing of sound by outer hair cells of the cochlea 35 4.06e-01 0.081200 5.98e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 6.00e-01 0.080900 7.64e-01
Neurotransmitter receptors and postsynaptic signal transmission 142 9.72e-02 -0.080700 2.17e-01
Cell-cell junction organization 63 2.68e-01 -0.080700 4.49e-01
Meiosis 50 3.25e-01 -0.080500 5.09e-01
Lagging Strand Synthesis 20 5.33e-01 0.080500 7.13e-01
CD28 dependent PI3K/Akt signaling 21 5.23e-01 -0.080500 7.05e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 6.30e-01 0.080300 7.75e-01
Branched-chain amino acid catabolism 21 5.24e-01 0.080300 7.05e-01
Signaling by CSF1 (M-CSF) in myeloid cells 31 4.39e-01 -0.080300 6.32e-01
Transmission across Chemical Synapses 188 5.85e-02 -0.080100 1.47e-01
EPHB-mediated forward signaling 39 3.87e-01 0.080100 5.80e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 6.46e-01 0.079900 7.84e-01
Synthesis of PE 12 6.33e-01 0.079700 7.75e-01
Nucleotide catabolism 25 4.92e-01 -0.079400 6.82e-01
Signal amplification 27 4.76e-01 -0.079200 6.66e-01
Recruitment of NuMA to mitotic centrosomes 87 2.05e-01 -0.078700 3.65e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 6.25e-01 -0.078400 7.75e-01
Caspase activation via extrinsic apoptotic signalling pathway 23 5.16e-01 -0.078300 7.02e-01
Estrogen-dependent gene expression 89 2.05e-01 -0.077700 3.65e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 6.71e-01 0.077700 7.99e-01
IRAK4 deficiency (TLR2/4) 15 6.03e-01 0.077500 7.64e-01
SARS-CoV-1 activates/modulates innate immune responses 39 4.04e-01 -0.077200 5.97e-01
Glutathione synthesis and recycling 10 6.73e-01 -0.077000 7.99e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 3.47e-01 -0.077000 5.32e-01
Cellular response to heat stress 96 1.93e-01 -0.076900 3.50e-01
CD28 co-stimulation 32 4.53e-01 -0.076700 6.45e-01
Platelet homeostasis 69 2.73e-01 -0.076400 4.53e-01
Pre-NOTCH Expression and Processing 54 3.37e-01 -0.075600 5.19e-01
Deposition of new CENPA-containing nucleosomes at the centromere 30 4.74e-01 -0.075500 6.66e-01
Nucleosome assembly 30 4.74e-01 -0.075500 6.66e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 6.03e-01 -0.075100 7.64e-01
IKK complex recruitment mediated by RIP1 23 5.35e-01 -0.074800 7.14e-01
Sphingolipid metabolism 73 2.71e-01 -0.074500 4.52e-01
VxPx cargo-targeting to cilium 17 5.97e-01 0.074100 7.62e-01
Opioid Signalling 79 2.59e-01 -0.073600 4.36e-01
Toll-like Receptor Cascades 157 1.13e-01 -0.073400 2.40e-01
PRC2 methylates histones and DNA 19 5.84e-01 -0.072600 7.52e-01
G alpha (12/13) signalling events 70 2.94e-01 0.072500 4.77e-01
Processing of SMDT1 15 6.27e-01 -0.072400 7.75e-01
Interleukin-2 family signaling 36 4.52e-01 -0.072400 6.45e-01
Phase II - Conjugation of compounds 69 3.00e-01 -0.072200 4.83e-01
Signaling by ERBB2 in Cancer 24 5.41e-01 0.072100 7.18e-01
Mucopolysaccharidoses 11 6.79e-01 0.072100 8.02e-01
Signaling by Non-Receptor Tyrosine Kinases 51 3.74e-01 -0.072000 5.66e-01
Signaling by PTK6 51 3.74e-01 -0.072000 5.66e-01
Nuclear import of Rev protein 34 4.70e-01 0.071600 6.62e-01
LDL clearance 17 6.12e-01 0.071000 7.68e-01
Meiotic synapsis 31 4.94e-01 -0.071000 6.84e-01
Integrin signaling 23 5.56e-01 -0.070900 7.29e-01
Peroxisomal protein import 57 3.56e-01 0.070700 5.45e-01
Caspase activation via Death Receptors in the presence of ligand 15 6.36e-01 -0.070600 7.77e-01
RND1 GTPase cycle 37 4.59e-01 0.070300 6.50e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 5.21e-01 0.070100 7.04e-01
Epigenetic regulation of gene expression 133 1.64e-01 0.070000 3.15e-01
RHOC GTPase cycle 70 3.12e-01 0.069900 4.96e-01
FRS-mediated FGFR1 signaling 15 6.41e-01 -0.069600 7.81e-01
SUMOylation of transcription cofactors 44 4.25e-01 -0.069500 6.18e-01
FGFR1 mutant receptor activation 25 5.48e-01 -0.069500 7.25e-01
Phospholipid metabolism 177 1.11e-01 0.069500 2.38e-01
Neuronal System 263 5.30e-02 -0.069400 1.38e-01
Ion channel transport 133 1.69e-01 -0.069100 3.22e-01
DNA Repair 280 4.73e-02 -0.069000 1.27e-01
Prostacyclin signalling through prostacyclin receptor 14 6.55e-01 -0.069000 7.90e-01
FOXO-mediated transcription of cell cycle genes 15 6.45e-01 -0.068700 7.84e-01
Deadenylation of mRNA 22 5.77e-01 0.068700 7.46e-01
RAC1 GTPase cycle 173 1.20e-01 0.068500 2.51e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 87 2.72e-01 -0.068200 4.52e-01
Amplification of signal from the kinetochores 87 2.72e-01 -0.068200 4.52e-01
Gap junction degradation 12 6.83e-01 -0.068200 8.03e-01
BBSome-mediated cargo-targeting to cilium 21 5.89e-01 -0.068100 7.57e-01
PCNA-Dependent Long Patch Base Excision Repair 21 5.92e-01 -0.067500 7.60e-01
Activation of RAC1 11 6.99e-01 0.067400 8.16e-01
Adenylate cyclase inhibitory pathway 13 6.77e-01 0.066800 8.01e-01
PI3K events in ERBB2 signaling 14 6.66e-01 0.066700 7.98e-01
Homologous DNA Pairing and Strand Exchange 41 4.63e-01 0.066200 6.54e-01
Nonhomologous End-Joining (NHEJ) 34 5.05e-01 0.066100 6.90e-01
Removal of the Flap Intermediate 14 6.70e-01 0.065800 7.99e-01
HDMs demethylate histones 21 6.03e-01 -0.065600 7.64e-01
FLT3 Signaling 36 4.97e-01 -0.065400 6.84e-01
Cell-extracellular matrix interactions 18 6.36e-01 -0.064500 7.77e-01
Signal regulatory protein family interactions 11 7.12e-01 0.064400 8.26e-01
Regulation of KIT signaling 16 6.57e-01 -0.064100 7.92e-01
Metabolism of non-coding RNA 53 4.20e-01 0.064000 6.12e-01
snRNP Assembly 53 4.20e-01 0.064000 6.12e-01
Signaling by EGFR 46 4.55e-01 -0.063700 6.47e-01
FCERI mediated MAPK activation 36 5.08e-01 -0.063700 6.94e-01
Biotin transport and metabolism 11 7.15e-01 -0.063600 8.28e-01
Other semaphorin interactions 19 6.33e-01 -0.063300 7.75e-01
Leishmania infection 155 1.75e-01 -0.063200 3.28e-01
Parasitic Infection Pathways 155 1.75e-01 -0.063200 3.28e-01
RET signaling 33 5.33e-01 -0.062700 7.13e-01
EPHA-mediated growth cone collapse 22 6.11e-01 -0.062600 7.68e-01
Antiviral mechanism by IFN-stimulated genes 79 3.37e-01 0.062600 5.19e-01
Regulation of FOXO transcriptional activity by acetylation 10 7.33e-01 0.062400 8.41e-01
E2F mediated regulation of DNA replication 21 6.21e-01 0.062400 7.75e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 32 5.43e-01 -0.062100 7.20e-01
Mitotic Prophase 88 3.14e-01 -0.062100 4.98e-01
Golgi Associated Vesicle Biogenesis 55 4.26e-01 -0.062000 6.19e-01
Signaling by GPCR 406 3.33e-02 -0.061700 1.00e-01
Mitochondrial Fatty Acid Beta-Oxidation 34 5.35e-01 -0.061400 7.14e-01
Cell junction organization 88 3.20e-01 -0.061400 5.04e-01
rRNA processing in the mitochondrion 10 7.37e-01 -0.061300 8.44e-01
Apoptotic factor-mediated response 20 6.38e-01 0.060800 7.78e-01
Activation of HOX genes during differentiation 65 3.98e-01 -0.060700 5.91e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 65 3.98e-01 -0.060700 5.91e-01
Activation of the pre-replicative complex 29 5.72e-01 -0.060600 7.42e-01
CDC42 GTPase cycle 146 2.08e-01 0.060400 3.68e-01
NCAM signaling for neurite out-growth 53 4.51e-01 -0.059900 6.45e-01
GPCR downstream signalling 365 5.15e-02 -0.059500 1.35e-01
Interleukin receptor SHC signaling 22 6.30e-01 -0.059400 7.75e-01
Semaphorin interactions 62 4.21e-01 -0.059200 6.12e-01
Mitotic Spindle Checkpoint 104 2.98e-01 -0.059100 4.80e-01
Glucagon signaling in metabolic regulation 26 6.04e-01 -0.058700 7.64e-01
Metabolism of water-soluble vitamins and cofactors 108 2.93e-01 -0.058600 4.76e-01
Interleukin-37 signaling 20 6.50e-01 0.058600 7.87e-01
RHO GTPases Activate ROCKs 18 6.68e-01 -0.058500 7.99e-01
Extra-nuclear estrogen signaling 66 4.13e-01 -0.058300 6.05e-01
Tryptophan catabolism 10 7.50e-01 0.058300 8.52e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 6.29e-01 -0.058100 7.75e-01
Intra-Golgi traffic 42 5.18e-01 -0.057700 7.03e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 6.19e-01 -0.057400 7.74e-01
RHO GTPases activate KTN1 10 7.54e-01 0.057100 8.55e-01
Regulation of Expression and Function of Type II Classical Cadherins 29 5.95e-01 -0.057000 7.60e-01
Regulation of Homotypic Cell-Cell Adhesion 29 5.95e-01 -0.057000 7.60e-01
SHC1 events in ERBB2 signaling 20 6.60e-01 -0.056900 7.93e-01
Metabolism of steroids 120 2.84e-01 -0.056700 4.66e-01
Aspirin ADME 14 7.14e-01 -0.056600 8.27e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 6.31e-01 0.056600 7.75e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 6.31e-01 0.056600 7.75e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 24 6.31e-01 0.056600 7.75e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 24 6.31e-01 0.056600 7.75e-01
mRNA Splicing - Major Pathway 202 1.67e-01 -0.056400 3.20e-01
Effects of PIP2 hydrolysis 22 6.47e-01 -0.056400 7.84e-01
Scavenging by Class A Receptors 16 6.97e-01 -0.056200 8.16e-01
CD28 dependent Vav1 pathway 11 7.47e-01 0.056100 8.50e-01
Early Phase of HIV Life Cycle 14 7.18e-01 -0.055700 8.30e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 4.71e-01 -0.055700 6.63e-01
EPH-ephrin mediated repulsion of cells 44 5.23e-01 -0.055700 7.05e-01
Myogenesis 21 6.59e-01 -0.055600 7.93e-01
RHOB GTPase cycle 66 4.40e-01 0.055000 6.32e-01
Formation of definitive endoderm 10 7.65e-01 0.054700 8.63e-01
ESR-mediated signaling 152 2.46e-01 -0.054600 4.19e-01
Maturation of nucleoprotein 9683610 11 7.54e-01 0.054600 8.55e-01
Defects in vitamin and cofactor metabolism 20 6.74e-01 0.054400 7.99e-01
Stimuli-sensing channels 72 4.26e-01 0.054300 6.18e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 5.58e-01 0.054300 7.29e-01
Diseases of DNA Double-Strand Break Repair 39 5.58e-01 0.054300 7.29e-01
SIRT1 negatively regulates rRNA expression 14 7.25e-01 0.054300 8.36e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 6.83e-01 -0.054200 8.03e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 6.83e-01 -0.054200 8.03e-01
Regulation of HSF1-mediated heat shock response 78 4.11e-01 -0.053900 6.03e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 5.73e-01 -0.053600 7.42e-01
NOD1/2 Signaling Pathway 36 5.80e-01 -0.053300 7.48e-01
G1/S-Specific Transcription 25 6.45e-01 -0.053300 7.84e-01
ERK/MAPK targets 22 6.66e-01 -0.053100 7.98e-01
Downstream signaling of activated FGFR1 21 6.74e-01 -0.053000 7.99e-01
Metabolism of porphyrins 21 6.74e-01 -0.053000 7.99e-01
Sensory processing of sound by inner hair cells of the cochlea 49 5.22e-01 -0.052900 7.04e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 66 4.57e-01 -0.052900 6.49e-01
Ion transport by P-type ATPases 42 5.53e-01 -0.052900 7.29e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 39 5.69e-01 -0.052700 7.39e-01
Activation of kainate receptors upon glutamate binding 23 6.63e-01 -0.052500 7.96e-01
Regulation of MECP2 expression and activity 29 6.32e-01 0.051400 7.75e-01
PKA-mediated phosphorylation of CREB 19 6.99e-01 0.051300 8.16e-01
DAP12 signaling 27 6.48e-01 0.050800 7.84e-01
Interactions of Rev with host cellular proteins 37 5.95e-01 0.050500 7.60e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 7.43e-01 -0.050500 8.49e-01
Activation of ATR in response to replication stress 31 6.27e-01 -0.050400 7.75e-01
Ephrin signaling 18 7.12e-01 0.050300 8.26e-01
Triglyceride catabolism 16 7.33e-01 -0.049200 8.41e-01
Signaling by ERBB2 47 5.60e-01 -0.049100 7.30e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 7.00e-01 -0.048600 8.16e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 7.00e-01 -0.048600 8.16e-01
Metabolism of steroid hormones 21 7.02e-01 -0.048200 8.18e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.31e-01 0.048200 8.40e-01
RHOD GTPase cycle 50 5.58e-01 0.047900 7.29e-01
HDR through Single Strand Annealing (SSA) 35 6.25e-01 0.047700 7.75e-01
CaM pathway 32 6.42e-01 0.047500 7.81e-01
Calmodulin induced events 32 6.42e-01 0.047500 7.81e-01
Signaling by BMP 23 6.95e-01 0.047200 8.16e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 4.13e-01 0.047200 6.05e-01
Synthesis of PA 29 6.61e-01 0.047000 7.95e-01
RNA polymerase II transcribes snRNA genes 71 4.94e-01 -0.046900 6.84e-01
DAP12 interactions 35 6.34e-01 -0.046500 7.76e-01
Dual incision in TC-NER 65 5.18e-01 -0.046400 7.03e-01
RHOBTB2 GTPase cycle 23 7.01e-01 -0.046200 8.17e-01
Signaling by NTRK2 (TRKB) 22 7.08e-01 0.046100 8.23e-01
Glycogen breakdown (glycogenolysis) 13 7.75e-01 -0.045700 8.70e-01
RNA Polymerase I Promoter Escape 37 6.30e-01 -0.045700 7.75e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.75e-01 -0.045700 8.00e-01
SHC1 events in EGFR signaling 11 7.93e-01 0.045600 8.80e-01
Regulated proteolysis of p75NTR 11 7.94e-01 -0.045500 8.80e-01
Vitamin B5 (pantothenate) metabolism 16 7.53e-01 -0.045500 8.54e-01
HDR through Homologous Recombination (HRR) 65 5.28e-01 0.045300 7.08e-01
p75 NTR receptor-mediated signalling 91 4.60e-01 -0.044800 6.51e-01
mRNA Splicing 210 2.67e-01 -0.044500 4.48e-01
DNA Double-Strand Break Repair 129 3.86e-01 -0.044300 5.79e-01
trans-Golgi Network Vesicle Budding 70 5.24e-01 -0.044000 7.05e-01
Transcriptional regulation of white adipocyte differentiation 81 4.96e-01 -0.043700 6.84e-01
NRAGE signals death through JNK 56 5.72e-01 0.043700 7.42e-01
ISG15 antiviral mechanism 71 5.26e-01 0.043500 7.06e-01
ALK mutants bind TKIs 12 7.95e-01 -0.043300 8.81e-01
Erythropoietin activates RAS 13 7.88e-01 -0.043200 8.78e-01
Ca2+ pathway 54 5.85e-01 0.042900 7.53e-01
Intraflagellar transport 49 6.04e-01 -0.042900 7.64e-01
Impaired BRCA2 binding to RAD51 33 6.71e-01 0.042700 7.99e-01
Signaling by NOTCH2 31 6.82e-01 -0.042600 8.03e-01
Reproduction 67 5.48e-01 -0.042500 7.25e-01
Signaling by ERBB2 KD Mutants 23 7.25e-01 0.042400 8.36e-01
Nuclear Envelope Breakdown 53 5.98e-01 0.041900 7.62e-01
Transcriptional Regulation by MECP2 48 6.18e-01 -0.041600 7.74e-01
Mitotic Prometaphase 188 3.28e-01 -0.041400 5.13e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 8.04e-01 0.041300 8.86e-01
Processive synthesis on the lagging strand 15 7.83e-01 0.041100 8.74e-01
PLC beta mediated events 46 6.30e-01 0.041100 7.75e-01
tRNA processing in the nucleus 59 5.91e-01 0.040500 7.59e-01
Homology Directed Repair 100 4.85e-01 -0.040500 6.75e-01
Netrin-1 signaling 41 6.55e-01 0.040300 7.90e-01
Triglyceride metabolism 24 7.34e-01 -0.040100 8.41e-01
Tie2 Signaling 15 7.90e-01 -0.039700 8.80e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 6.06e-01 0.039500 7.64e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 6.06e-01 0.039500 7.64e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 6.06e-01 0.039500 7.64e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 6.06e-01 0.039500 7.64e-01
Signaling by NOTCH1 in Cancer 57 6.06e-01 0.039500 7.64e-01
HDR through MMEJ (alt-NHEJ) 12 8.13e-01 0.039400 8.90e-01
Polymerase switching on the C-strand of the telomere 26 7.28e-01 0.039400 8.38e-01
Transcriptional Regulation by E2F6 34 6.91e-01 0.039400 8.12e-01
LGI-ADAM interactions 10 8.30e-01 0.039300 8.97e-01
Deadenylation-dependent mRNA decay 50 6.32e-01 -0.039200 7.75e-01
Regulation of lipid metabolism by PPARalpha 106 4.89e-01 0.038900 6.80e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 6.78e-01 0.038900 8.02e-01
Class B/2 (Secretin family receptors) 51 6.33e-01 -0.038700 7.75e-01
RNA Polymerase III Abortive And Retractive Initiation 41 6.69e-01 -0.038600 7.99e-01
RNA Polymerase III Transcription 41 6.69e-01 -0.038600 7.99e-01
Regulation of beta-cell development 19 7.73e-01 0.038200 8.70e-01
Mitochondrial calcium ion transport 21 7.62e-01 -0.038200 8.61e-01
Cargo recognition for clathrin-mediated endocytosis 91 5.40e-01 -0.037200 7.18e-01
Hyaluronan metabolism 16 8.00e-01 -0.036500 8.84e-01
Potassium Channels 52 6.51e-01 -0.036300 7.87e-01
FOXO-mediated transcription 57 6.37e-01 -0.036100 7.78e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 31 7.28e-01 -0.036100 8.38e-01
Phase 0 - rapid depolarisation 23 7.65e-01 -0.036000 8.63e-01
Signaling by Rho GTPases 599 1.38e-01 -0.035600 2.80e-01
Fanconi Anemia Pathway 35 7.16e-01 0.035600 8.28e-01
Clathrin-mediated endocytosis 130 4.84e-01 -0.035600 6.74e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 8.33e-01 -0.035300 8.99e-01
PPARA activates gene expression 104 5.36e-01 0.035100 7.14e-01
Regulation of PLK1 Activity at G2/M Transition 85 5.77e-01 -0.035000 7.46e-01
RNA Polymerase II Transcription Termination 66 6.25e-01 0.034800 7.75e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 8.28e-01 -0.034700 8.96e-01
Negative regulation of MET activity 20 7.88e-01 -0.034700 8.78e-01
Cell-Cell communication 116 5.20e-01 -0.034600 7.03e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 614 1.46e-01 -0.034500 2.91e-01
RHOJ GTPase cycle 53 6.67e-01 0.034200 7.98e-01
Prolonged ERK activation events 14 8.26e-01 0.034000 8.95e-01
Retrograde transport at the Trans-Golgi-Network 49 6.82e-01 -0.033900 8.03e-01
PECAM1 interactions 12 8.40e-01 -0.033700 9.03e-01
Frs2-mediated activation 12 8.40e-01 0.033600 9.03e-01
GPVI-mediated activation cascade 32 7.43e-01 -0.033400 8.49e-01
Signaling by EGFR in Cancer 22 7.87e-01 -0.033300 8.78e-01
Gene Silencing by RNA 78 6.12e-01 0.033200 7.68e-01
Sphingolipid de novo biosynthesis 37 7.27e-01 0.033100 8.38e-01
Signaling by NOTCH3 46 6.98e-01 -0.033100 8.16e-01
Cell recruitment (pro-inflammatory response) 24 7.80e-01 -0.032900 8.73e-01
Purinergic signaling in leishmaniasis infection 24 7.80e-01 -0.032900 8.73e-01
Cytochrome P450 - arranged by substrate type 32 7.48e-01 0.032900 8.50e-01
RHO GTPases Activate WASPs and WAVEs 35 7.39e-01 -0.032600 8.46e-01
FLT3 signaling in disease 27 7.72e-01 -0.032200 8.70e-01
RHO GTPases activate CIT 18 8.15e-01 -0.031900 8.90e-01
Postmitotic nuclear pore complex (NPC) reformation 27 7.75e-01 -0.031700 8.70e-01
Endogenous sterols 20 8.08e-01 -0.031500 8.87e-01
Phase I - Functionalization of compounds 65 6.63e-01 0.031200 7.96e-01
ADORA2B mediated anti-inflammatory cytokines production 36 7.47e-01 -0.031100 8.50e-01
TBC/RABGAPs 44 7.22e-01 -0.031000 8.34e-01
Ca-dependent events 34 7.56e-01 0.030900 8.55e-01
Nuclear signaling by ERBB4 28 7.78e-01 0.030800 8.72e-01
TRAF6 mediated NF-kB activation 23 7.98e-01 0.030800 8.83e-01
IRF3-mediated induction of type I IFN 12 8.54e-01 0.030700 9.10e-01
Phosphorylation of the APC/C 20 8.14e-01 -0.030400 8.90e-01
Thromboxane signalling through TP receptor 19 8.19e-01 -0.030300 8.92e-01
Telomere C-strand (Lagging Strand) Synthesis 34 7.60e-01 -0.030200 8.60e-01
G-protein activation 18 8.26e-01 0.029900 8.95e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 8.22e-01 0.029700 8.93e-01
Organelle biogenesis and maintenance 271 4.07e-01 -0.029300 5.99e-01
PKA activation 17 8.35e-01 -0.029100 9.01e-01
Biological oxidations 138 5.57e-01 -0.029000 7.29e-01
G alpha (s) signalling events 85 6.47e-01 -0.028700 7.84e-01
Glyoxylate metabolism and glycine degradation 23 8.12e-01 -0.028700 8.90e-01
Regulation of TLR by endogenous ligand 15 8.48e-01 0.028500 9.07e-01
Visual phototransduction 58 7.13e-01 -0.027900 8.27e-01
Class I peroxisomal membrane protein import 19 8.34e-01 -0.027800 9.00e-01
EPH-Ephrin signaling 82 6.73e-01 -0.026900 7.99e-01
Anchoring of the basal body to the plasma membrane 95 6.59e-01 0.026200 7.93e-01
SLC transporter disorders 70 7.05e-01 0.026100 8.21e-01
Transcriptional regulation by small RNAs 53 7.45e-01 -0.025900 8.49e-01
RAC2 GTPase cycle 85 6.83e-01 0.025600 8.04e-01
GRB2 events in ERBB2 signaling 14 8.68e-01 0.025600 9.24e-01
Interaction between L1 and Ankyrins 25 8.25e-01 -0.025500 8.95e-01
Laminin interactions 27 8.19e-01 -0.025500 8.92e-01
Activation of GABAB receptors 32 8.03e-01 -0.025400 8.86e-01
GABA B receptor activation 32 8.03e-01 -0.025400 8.86e-01
RHO GTPases activate PKNs 36 7.93e-01 -0.025300 8.80e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 8.41e-01 -0.025300 9.03e-01
PI-3K cascade:FGFR1 13 8.78e-01 -0.024500 9.28e-01
RHO GTPase cycle 419 3.91e-01 0.024500 5.83e-01
Signaling by Nuclear Receptors 214 5.41e-01 -0.024300 7.18e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 7.74e-01 -0.024200 8.70e-01
Diseases of DNA repair 48 7.72e-01 0.024200 8.70e-01
MyD88 deficiency (TLR2/4) 14 8.76e-01 0.024100 9.27e-01
Pre-NOTCH Transcription and Translation 38 7.99e-01 0.023900 8.83e-01
G-protein mediated events 50 7.73e-01 0.023600 8.70e-01
SUMO E3 ligases SUMOylate target proteins 162 6.04e-01 0.023600 7.64e-01
ADP signalling through P2Y purinoceptor 12 16 8.70e-01 0.023600 9.25e-01
Signaling by high-kinase activity BRAF mutants 31 8.21e-01 0.023500 8.93e-01
Maturation of nucleoprotein 9694631 15 8.75e-01 -0.023500 9.26e-01
B-WICH complex positively regulates rRNA expression 37 8.06e-01 0.023300 8.87e-01
MAP2K and MAPK activation 35 8.11e-01 0.023300 8.90e-01
Sensory Perception 148 6.28e-01 0.023100 7.75e-01
ADP signalling through P2Y purinoceptor 1 20 8.58e-01 -0.023100 9.14e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 8.18e-01 0.022800 8.92e-01
Positive epigenetic regulation of rRNA expression 52 7.76e-01 -0.022800 8.70e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 8.54e-01 0.022700 9.10e-01
Signaling by NOTCH1 72 7.42e-01 0.022500 8.49e-01
Sensory processing of sound 52 7.82e-01 -0.022200 8.74e-01
Inositol phosphate metabolism 42 8.05e-01 -0.022100 8.86e-01
VEGFR2 mediated vascular permeability 27 8.45e-01 0.021700 9.06e-01
DNA Damage Bypass 46 8.02e-01 0.021400 8.85e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 8.99e-01 0.021200 9.46e-01
Arachidonic acid metabolism 36 8.25e-01 0.021200 8.95e-01
Cargo trafficking to the periciliary membrane 45 8.07e-01 0.021000 8.87e-01
Defective B3GALTL causes PpS 34 8.38e-01 0.020300 9.02e-01
G2/M DNA damage checkpoint 57 7.93e-01 -0.020100 8.80e-01
p130Cas linkage to MAPK signaling for integrins 12 9.05e-01 -0.019900 9.49e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 94 7.44e-01 -0.019500 8.49e-01
Transcriptional activation of mitochondrial biogenesis 49 8.17e-01 -0.019100 8.92e-01
SUMOylation of chromatin organization proteins 57 8.09e-01 0.018600 8.88e-01
Germ layer formation at gastrulation 11 9.17e-01 0.018200 9.54e-01
Signaling by PDGFR in disease 20 8.88e-01 -0.018200 9.35e-01
Glycerophospholipid biosynthesis 100 7.55e-01 -0.018000 8.55e-01
Cilium Assembly 186 6.74e-01 0.017900 7.99e-01
Oncogenic MAPK signaling 74 7.92e-01 0.017700 8.80e-01
Viral Messenger RNA Synthesis 44 8.39e-01 -0.017700 9.03e-01
Drug ADME 58 8.18e-01 -0.017500 8.92e-01
DAG and IP3 signaling 38 8.53e-01 -0.017300 9.10e-01
SUMOylation of transcription factors 17 9.02e-01 0.017200 9.48e-01
Nephrin family interactions 18 8.99e-01 -0.017200 9.46e-01
Interferon Signaling 166 7.07e-01 -0.016900 8.22e-01
Sema3A PAK dependent Axon repulsion 16 9.07e-01 -0.016900 9.49e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.25e-01 0.016300 9.59e-01
Diseases associated with the TLR signaling cascade 27 8.85e-01 0.016100 9.33e-01
Diseases of Immune System 27 8.85e-01 0.016100 9.33e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 9.21e-01 0.015900 9.56e-01
Chromatin modifying enzymes 203 6.97e-01 -0.015900 8.16e-01
Chromatin organization 203 6.97e-01 -0.015900 8.16e-01
RHOH GTPase cycle 32 8.77e-01 0.015800 9.27e-01
Gene expression (Transcription) 1357 3.34e-01 0.015800 5.18e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 9.34e-01 0.015200 9.64e-01
Tight junction interactions 17 9.14e-01 0.015200 9.53e-01
Nuclear Receptor transcription pathway 40 8.71e-01 -0.014800 9.25e-01
RNA Polymerase I Promoter Clearance 56 8.49e-01 -0.014700 9.07e-01
RNA Polymerase I Transcription 56 8.49e-01 -0.014700 9.07e-01
Synthesis of IP3 and IP4 in the cytosol 22 9.06e-01 0.014600 9.49e-01
RHO GTPases Activate NADPH Oxidases 21 9.08e-01 -0.014500 9.49e-01
tRNA processing 109 7.93e-01 0.014500 8.80e-01
MTOR signalling 40 8.75e-01 -0.014400 9.26e-01
SUMOylation 168 7.50e-01 0.014300 8.52e-01
tRNA modification in the nucleus and cytosol 43 8.72e-01 -0.014200 9.25e-01
Cytosolic iron-sulfur cluster assembly 13 9.30e-01 -0.014100 9.63e-01
RHOF GTPase cycle 39 8.83e-01 0.013700 9.32e-01
RAB GEFs exchange GTP for GDP on RABs 87 8.27e-01 -0.013600 8.95e-01
Signaling by VEGF 105 8.14e-01 -0.013300 8.90e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.20e-01 0.013000 9.56e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 9.15e-01 -0.012600 9.54e-01
Signaling by BRAF and RAF1 fusions 58 8.72e-01 0.012200 9.25e-01
Signaling by FGFR1 in disease 32 9.06e-01 0.012100 9.49e-01
RAC3 GTPase cycle 87 8.48e-01 -0.011900 9.07e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 9.34e-01 0.011600 9.64e-01
G alpha (q) signalling events 130 8.22e-01 0.011500 8.93e-01
VEGFA-VEGFR2 Pathway 96 8.52e-01 -0.011100 9.10e-01
Rab regulation of trafficking 119 8.38e-01 -0.010900 9.02e-01
Generic Transcription Pathway 1080 5.54e-01 0.010800 7.29e-01
Signaling by Activin 13 9.52e-01 -0.009610 9.71e-01
Signaling by ERBB2 TMD/JMD mutants 20 9.42e-01 -0.009460 9.68e-01
HS-GAG degradation 22 9.39e-01 0.009440 9.68e-01
SUMOylation of RNA binding proteins 47 9.11e-01 0.009430 9.51e-01
Regulation of CDH11 Expression and Function 27 9.33e-01 -0.009380 9.64e-01
Processing of Capped Intronless Pre-mRNA 29 9.31e-01 0.009260 9.64e-01
Signaling by ERBB4 51 9.10e-01 -0.009120 9.51e-01
Regulation of signaling by CBL 22 9.42e-01 -0.008940 9.68e-01
Recognition of DNA damage by PCNA-containing replication complex 30 9.34e-01 0.008700 9.64e-01
RNA Polymerase II Transcription 1198 6.20e-01 0.008590 7.74e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.47e-01 -0.008590 9.70e-01
RNA Polymerase I Transcription Initiation 47 9.20e-01 -0.008510 9.56e-01
Fatty acid metabolism 140 8.63e-01 0.008430 9.19e-01
Plasma lipoprotein clearance 32 9.37e-01 -0.008090 9.66e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 9.65e-01 0.007920 9.78e-01
SARS-CoV-2 modulates autophagy 11 9.64e-01 0.007840 9.78e-01
Centrosome maturation 79 9.06e-01 -0.007660 9.49e-01
Recruitment of mitotic centrosome proteins and complexes 79 9.06e-01 -0.007660 9.49e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 63 9.17e-01 -0.007640 9.54e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 9.43e-01 0.007520 9.68e-01
RNA Polymerase I Transcription Termination 30 9.44e-01 0.007400 9.68e-01
Signaling by Retinoic Acid 36 9.39e-01 0.007340 9.68e-01
Amine ligand-binding receptors 11 9.67e-01 -0.007170 9.78e-01
Processing of Capped Intron-Containing Pre-mRNA 278 8.45e-01 0.006850 9.06e-01
RHOA GTPase cycle 143 8.88e-01 0.006820 9.35e-01
Loss of Nlp from mitotic centrosomes 67 9.24e-01 0.006720 9.59e-01
Loss of proteins required for interphase microtubule organization from the centrosome 67 9.24e-01 0.006720 9.59e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 9.65e-01 -0.006520 9.78e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 9.65e-01 -0.006520 9.78e-01
WNT ligand biogenesis and trafficking 17 9.64e-01 0.006390 9.78e-01
Signaling by RAF1 mutants 36 9.49e-01 -0.006110 9.71e-01
O-glycosylation of TSR domain-containing proteins 35 9.52e-01 0.005840 9.71e-01
Dual Incision in GG-NER 41 9.50e-01 0.005710 9.71e-01
Signaling by SCF-KIT 41 9.51e-01 0.005600 9.71e-01
Signaling by Hippo 20 9.66e-01 -0.005580 9.78e-01
Telomere C-strand synthesis initiation 13 9.73e-01 -0.005510 9.81e-01
GABA receptor activation 40 9.54e-01 0.005310 9.71e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 43 9.54e-01 -0.005060 9.71e-01
NoRC negatively regulates rRNA expression 52 9.50e-01 -0.005020 9.71e-01
Cell death signalling via NRAGE, NRIF and NADE 73 9.41e-01 -0.004990 9.68e-01
Negative epigenetic regulation of rRNA expression 55 9.52e-01 0.004670 9.71e-01
Transcriptional Regulation by NPAS4 30 9.65e-01 0.004660 9.78e-01
HATs acetylate histones 82 9.43e-01 -0.004550 9.68e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.76e-01 -0.004390 9.82e-01
SUMOylation of DNA replication proteins 46 9.60e-01 -0.004300 9.76e-01
Nicotinate metabolism 27 9.75e-01 -0.003510 9.82e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 9.72e-01 0.003260 9.80e-01
Signaling by RAS mutants 40 9.72e-01 0.003260 9.80e-01
Signaling by moderate kinase activity BRAF mutants 40 9.72e-01 0.003260 9.80e-01
Signaling downstream of RAS mutants 40 9.72e-01 0.003260 9.80e-01
Cardiogenesis 19 9.81e-01 0.003090 9.87e-01
Nicotinamide salvaging 16 9.83e-01 0.003000 9.88e-01
Phase 2 - plateau phase 10 9.90e-01 -0.002240 9.93e-01
Metabolism of lipids 599 9.42e-01 0.001760 9.68e-01
Interferon gamma signaling 74 9.80e-01 0.001700 9.86e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 9.91e-01 0.001610 9.93e-01
Termination of translesion DNA synthesis 31 9.90e-01 0.001260 9.93e-01
Aquaporin-mediated transport 36 9.90e-01 -0.001220 9.93e-01
Glucagon-type ligand receptors 17 9.94e-01 -0.001030 9.95e-01
Thrombin signalling through proteinase activated receptors (PARs) 24 9.94e-01 0.000941 9.95e-01
AURKA Activation by TPX2 70 9.96e-01 0.000335 9.96e-01


Detailed Gene set reports



Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
698
set Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
setSize 13
pANOVA 1.56e-05
s.dist -0.692
p.adjustANOVA 0.00011



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
GJA1 -7862
TUBA8 -7620
TUBB2A -7115
TUBB2B -6815
TUBB3 -6598
TUBB4B -5898
TUBA1C -5471
TUBB6 -4118
TUBA1B -3972
TUBA1A -2543
TUBAL3 -1466

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
GJA1 -7862
TUBA8 -7620
TUBB2A -7115
TUBB2B -6815
TUBB3 -6598
TUBB4B -5898
TUBA1C -5471
TUBB6 -4118
TUBA1B -3972
TUBA1A -2543
TUBAL3 -1466


Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
425
set Formation of tubulin folding intermediates by CCT/TriC
setSize 21
pANOVA 1.95e-07
s.dist -0.656
p.adjustANOVA 2.09e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
CCT3 -7729
TUBA8 -7620
TUBB2A -7115
CCT7 -7087
TUBB2B -6815
CCT4 -6628
TUBB3 -6598
TCP1 -6549
TUBB4B -5898
CCT2 -5655
TUBA1C -5471
CCT8 -4656
TUBB6 -4118
CCT6A -4055
TUBA1B -3972
CCT5 -3161
CCT6B -2853
TUBA1A -2543

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
CCT3 -7729
TUBA8 -7620
TUBB2A -7115
CCT7 -7087
TUBB2B -6815
CCT4 -6628
TUBB3 -6598
TCP1 -6549
TUBB4B -5898
CCT2 -5655
TUBA1C -5471
CCT8 -4656
TUBB6 -4118
CCT6A -4055
TUBA1B -3972
CCT5 -3161
CCT6B -2853
TUBA1A -2543
TUBAL3 -1466


Transport of connexons to the plasma membrane

Transport of connexons to the plasma membrane
1394
set Transport of connexons to the plasma membrane
setSize 14
pANOVA 4.42e-05
s.dist -0.63
p.adjustANOVA 0.000294



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
GJA1 -7862
TUBA8 -7620
TUBB2A -7115
TUBB2B -6815
TUBB3 -6598
TUBB4B -5898
TUBA1C -5471
TUBB6 -4118
TUBA1B -3972
TUBA1A -2543
TUBAL3 -1466
GJB2 1325

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
GJA1 -7862
TUBA8 -7620
TUBB2A -7115
TUBB2B -6815
TUBB3 -6598
TUBB4B -5898
TUBA1C -5471
TUBB6 -4118
TUBA1B -3972
TUBA1A -2543
TUBAL3 -1466
GJB2 1325


Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
405
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.000871
s.dist -0.608
p.adjustANOVA 0.00437



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCT3 -7729
CCT7 -7087
CCT4 -6628
TCP1 -6549
CCT2 -5655
CCT8 -4656
CCT6A -4055
ACTB -3223
CCT5 -3161
CCT6B -2853

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT3 -7729
CCT7 -7087
CCT4 -6628
TCP1 -6549
CCT2 -5655
CCT8 -4656
CCT6A -4055
ACTB -3223
CCT5 -3161
CCT6B -2853


Prefoldin mediated transfer of substrate to CCT/TriC

Prefoldin mediated transfer of substrate to CCT/TriC
898
set Prefoldin mediated transfer of substrate to CCT/TriC
setSize 25
pANOVA 2.32e-07
s.dist -0.597
p.adjustANOVA 2.4e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
PFDN2 -8138
CCT3 -7729
TUBB2A -7115
CCT7 -7087
TUBB2B -6815
CCT4 -6628
TUBB3 -6598
TCP1 -6549
PFDN1 -6477
TUBB4B -5898
CCT2 -5655
TUBA1C -5471
CCT8 -4656
PFDN5 -4632
TUBB6 -4118
CCT6A -4055
PFDN6 -4013
ACTB -3223

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
PFDN2 -8138
CCT3 -7729
TUBB2A -7115
CCT7 -7087
TUBB2B -6815
CCT4 -6628
TUBB3 -6598
TCP1 -6549
PFDN1 -6477
TUBB4B -5898
CCT2 -5655
TUBA1C -5471
CCT8 -4656
PFDN5 -4632
TUBB6 -4118
CCT6A -4055
PFDN6 -4013
ACTB -3223
CCT5 -3161
CCT6B -2853
TUBA1A -2543
VBP1 75
PFDN4 3324


Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
225
set Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
setSize 28
pANOVA 7.05e-08
s.dist -0.588
p.adjustANOVA 8.37e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
PFDN2 -8138
CCT3 -7729
TUBA8 -7620
TUBB2A -7115
CCT7 -7087
TUBB2B -6815
CCT4 -6628
TUBB3 -6598
TCP1 -6549
PFDN1 -6477
TUBB4B -5898
CCT2 -5655
TUBA1C -5471
CCT8 -4656
PFDN5 -4632
TUBB6 -4118
CCT6A -4055
PFDN6 -4013

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB1 -8378
TUBA4A -8303
PFDN2 -8138
CCT3 -7729
TUBA8 -7620
TUBB2A -7115
CCT7 -7087
TUBB2B -6815
CCT4 -6628
TUBB3 -6598
TCP1 -6549
PFDN1 -6477
TUBB4B -5898
CCT2 -5655
TUBA1C -5471
CCT8 -4656
PFDN5 -4632
TUBB6 -4118
CCT6A -4055
PFDN6 -4013
TUBA1B -3972
ACTB -3223
CCT5 -3161
CCT6B -2853
TUBA1A -2543
TUBAL3 -1466
VBP1 75
PFDN4 3324


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
370
set Eukaryotic Translation Elongation
setSize 92
pANOVA 6.24e-22
s.dist -0.58
p.adjustANOVA 1.15e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
EEF1A2 -8395
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EEF2 -7489
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
EEF1G -6441
RPL37 -6352
RPL8 -6270

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EEF1A2 -8395
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EEF2 -7489
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
EEF1G -6441
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
EEF1B2 -5421
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
EEF1D -4712
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
EEF1A1P5 -4398
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
EEF1A1 -3602
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPL36A -1431
RPS4Y1 -434
RPS26 851


Josephin domain DUBs

Josephin domain DUBs
616
set Josephin domain DUBs
setSize 10
pANOVA 0.00169
s.dist -0.573
p.adjustANOVA 0.00789



Top enriched genes

Top 20 genes
GeneID Gene Rank
VCP -7846
UBB -7624
UBC -7582
JOSD1 -6977
RAD23A -6962
UBA52 -6597
RAD23B -5777
JOSD2 -4891
RPS27A -2686
ATXN3 8226

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VCP -7846
UBB -7624
UBC -7582
JOSD1 -6977
RAD23A -6962
UBA52 -6597
RAD23B -5777
JOSD2 -4891
RPS27A -2686
ATXN3 8226


Peptide chain elongation

Peptide chain elongation
856
set Peptide chain elongation
setSize 87
pANOVA 2.25e-20
s.dist -0.573
p.adjustANOVA 1.84e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EEF2 -7489
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EEF2 -7489
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
EEF1A1 -3602
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPL36A -1431
RPS4Y1 -434
RPS26 851


TP53 Regulates Transcription of Death Receptors and Ligands

TP53 Regulates Transcription of Death Receptors and Ligands
1309
set TP53 Regulates Transcription of Death Receptors and Ligands
setSize 10
pANOVA 0.00184
s.dist -0.569
p.adjustANOVA 0.00853



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFRSF10C -8405
TNFRSF10D -8116
TP53BP2 -6984
IGFBP3 -6885
TNFRSF10B -6801
TP53 -6483
FAS -3540
TNFRSF10A -2175
TMEM219 -1235
PPP1R13B 2282

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFRSF10C -8405
TNFRSF10D -8116
TP53BP2 -6984
IGFBP3 -6885
TNFRSF10B -6801
TP53 -6483
FAS -3540
TNFRSF10A -2175
TMEM219 -1235
PPP1R13B 2282


Gluconeogenesis

Gluconeogenesis
482
set Gluconeogenesis
setSize 27
pANOVA 3.56e-07
s.dist -0.566
p.adjustANOVA 3.44e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALDOC -8213
PGAM1 -8175
TPI1 -8029
GPI -7983
ALDOA -7961
PGK1 -7888
PCK1 -7730
ENO1 -7573
SLC25A11 -7530
PC -7155
MDH2 -7105
SLC25A1 -7036
GAPDH -6785
SLC25A10 -6556
GOT1 -6546
ENO2 -6414
GOT2 -5883
MDH1 -5842
ENO3 -4756
G6PC3 -3488

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALDOC -8213
PGAM1 -8175
TPI1 -8029
GPI -7983
ALDOA -7961
PGK1 -7888
PCK1 -7730
ENO1 -7573
SLC25A11 -7530
PC -7155
MDH2 -7105
SLC25A1 -7036
GAPDH -6785
SLC25A10 -6556
GOT1 -6546
ENO2 -6414
GOT2 -5883
MDH1 -5842
ENO3 -4756
G6PC3 -3488
SLC25A12 -2159
FBP1 155
SLC25A13 954
SLC37A2 1836
PCK2 1967
SLC37A1 3055
SLC37A4 3101


Viral mRNA Translation

Viral mRNA Translation
1424
set Viral mRNA Translation
setSize 87
pANOVA 7.33e-20
s.dist -0.565
p.adjustANOVA 5e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
DNAJC3 -3136
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
GRSF1 -2289
RPL9 -2284
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPL36A -1431
RPS4Y1 -434
RPS26 851


Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen
364
set Erythrocytes take up carbon dioxide and release oxygen
setSize 10
pANOVA 0.00201
s.dist -0.564
p.adjustANOVA 0.00913



Top enriched genes

Top 20 genes
GeneID Gene Rank
HBB -8432
HBA1 -8431
SLC4A1 -8426
CA1 -8338
CA2 -8322
CYB5R1 -7941
CYB5R2 -6458
AQP1 -2308
CYB5R4 5115
CYB5RL 5605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HBB -8432
HBA1 -8431
SLC4A1 -8426
CA1 -8338
CA2 -8322
CYB5R1 -7941
CYB5R2 -6458
AQP1 -2308
CYB5R4 5115
CYB5RL 5605


O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes
809
set O2/CO2 exchange in erythrocytes
setSize 10
pANOVA 0.00201
s.dist -0.564
p.adjustANOVA 0.00913



Top enriched genes

Top 20 genes
GeneID Gene Rank
HBB -8432
HBA1 -8431
SLC4A1 -8426
CA1 -8338
CA2 -8322
CYB5R1 -7941
CYB5R2 -6458
AQP1 -2308
CYB5R4 5115
CYB5RL 5605

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HBB -8432
HBA1 -8431
SLC4A1 -8426
CA1 -8338
CA2 -8322
CYB5R1 -7941
CYB5R2 -6458
AQP1 -2308
CYB5R4 5115
CYB5RL 5605


Keratan sulfate biosynthesis

Keratan sulfate biosynthesis
619
set Keratan sulfate biosynthesis
setSize 26
pANOVA 6.42e-07
s.dist -0.564
p.adjustANOVA 6.02e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAN -8364
ST3GAL2 -7975
CHST6 -7948
OMD -7768
B4GALT3 -7638
OGN -7543
B4GALT5 -7319
ST3GAL3 -7316
CHST1 -7309
LUM -7308
ST3GAL1 -7307
FMOD -7200
B4GALT1 -7195
B4GALT2 -6989
PRELP -6737
B4GALT4 -6720
ST3GAL4 -6387
B4GALT6 -5564
CHST5 -4724
B3GNT7 -3337

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN -8364
ST3GAL2 -7975
CHST6 -7948
OMD -7768
B4GALT3 -7638
OGN -7543
B4GALT5 -7319
ST3GAL3 -7316
CHST1 -7309
LUM -7308
ST3GAL1 -7307
FMOD -7200
B4GALT1 -7195
B4GALT2 -6989
PRELP -6737
B4GALT4 -6720
ST3GAL4 -6387
B4GALT6 -5564
CHST5 -4724
B3GNT7 -3337
KERA -2985
B4GAT1 -1389
SLC35D2 1766
CHST2 3767
ST3GAL6 6384
B3GNT2 6610


Eukaryotic Translation Termination

Eukaryotic Translation Termination
372
set Eukaryotic Translation Termination
setSize 91
pANOVA 7.47e-20
s.dist -0.553
p.adjustANOVA 5e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
GSPT1 -7498
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
GSPT1 -7498
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
APEH -4731
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
TRMT112 -3997
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
ETF1 -2714
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPL36A -1431
RPS4Y1 -434
GSPT2 -212
RPS26 851
N6AMT1 4223


STAT3 nuclear events downstream of ALK signaling

STAT3 nuclear events downstream of ALK signaling
1126
set STAT3 nuclear events downstream of ALK signaling
setSize 10
pANOVA 0.00281
s.dist -0.546
p.adjustANOVA 0.0122



Top enriched genes

Top 20 genes
GeneID Gene Rank
HIF1A -8219
IL2RG -8157
STAT3 -7798
PRDM1 -7683
HDAC1 -5692
CD274 -4927
SIN3A -3893
HDAC3 -2263
HDAC2 -600
EP300 2823

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HIF1A -8219
IL2RG -8157
STAT3 -7798
PRDM1 -7683
HDAC1 -5692
CD274 -4927
SIN3A -3893
HDAC3 -2263
HDAC2 -600
EP300 2823


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1100
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 1.45e-08
s.dist -0.546
p.adjustANOVA 2e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS19 -7713
RPS2 -7641
RPS29 -7209
RPS3 -6819
RPS18 -6137
RPS27 -6115
RPSA -6061
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPS15 -5859
RPS12 -5766
RPS21 -5750
RPS16 -5397
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPS6 -5018
RPS17 -4895

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS19 -7713
RPS2 -7641
RPS29 -7209
RPS3 -6819
RPS18 -6137
RPS27 -6115
RPSA -6061
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPS15 -5859
RPS12 -5766
RPS21 -5750
RPS16 -5397
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPS6 -5018
RPS17 -4895
RPS25 -4561
RPS15A -4397
RPS10 -4241
RPS13 -4077
HNRNPA1 -3944
RPS27L -3846
EEF1A1 -3602
RPS23 -3513
RPS24 -3505
RPS7 -3126
RPS27A -2686
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPS4Y1 -434
RPS26 851


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
415
set Formation of a pool of free 40S subunits
setSize 99
pANOVA 1.09e-20
s.dist -0.542
p.adjustANOVA 1.12e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF3I -7463
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
EIF3B -6355
RPL37 -6352
RPL8 -6270
RPS18 -6137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF3I -7463
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
EIF3B -6355
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
EIF3G -5696
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
EIF3H -4971
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
EIF3A -4296
RPS10 -4241
RPL6 -4135
EIF3F -4130
EIF3K -4108
RPL15 -4083
RPS13 -4077
RPL36AL -3945
EIF3L -3920
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
EIF3D -1816
RPS14 -1548
EIF3J -1514
RPL36A -1431
EIF3E -1084
RPS4Y1 -434
RPS26 851
EIF3M 1103
EIF1AX 6869


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
786
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 93
pANOVA 2.33e-19
s.dist -0.539
p.adjustANOVA 1.49e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
GSPT1 -7498
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
GSPT1 -7498
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
UPF1 -3732
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
ETF1 -2714
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPL36A -1431
RPS4Y1 -434
GSPT2 -212
RPS26 851
NCBP1 1670
NCBP2 2498
PABPC1 2772


Syndecan interactions

Syndecan interactions
1266
set Syndecan interactions
setSize 26
pANOVA 2e-06
s.dist -0.539
p.adjustANOVA 1.61e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACTN1 -8301
SDC4 -8048
TNC -7796
ITGB5 -7775
TGFB1 -7715
COL1A1 -7605
PRKCA -7526
COL5A2 -7285
COL1A2 -7023
COL3A1 -6980
SDC1 -6611
CASK -6607
COL5A1 -6582
THBS1 -6203
ITGB1 -5796
TRAPPC4 -5672
FGF2 -4492
FN1 -3998
ITGA2 -3587
ITGB3 -2858

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACTN1 -8301
SDC4 -8048
TNC -7796
ITGB5 -7775
TGFB1 -7715
COL1A1 -7605
PRKCA -7526
COL5A2 -7285
COL1A2 -7023
COL3A1 -6980
SDC1 -6611
CASK -6607
COL5A1 -6582
THBS1 -6203
ITGB1 -5796
TRAPPC4 -5672
FGF2 -4492
FN1 -3998
ITGA2 -3587
ITGB3 -2858
ITGAV -2688
COL5A3 -2134
SDC3 35
ITGB4 2824
SDC2 4937
ITGA6 6483


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1125
set SRP-dependent cotranslational protein targeting to membrane
setSize 110
pANOVA 4e-22
s.dist -0.533
p.adjustANOVA 8.41e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
SSR4 -8245
SSR2 -7984
RPLP0 -7891
SRPRA -7742
RPS19 -7713
RPL3 -7686
RPS2 -7641
DDOST -7516
RPL28 -7343
RPN1 -7287
RPS29 -7209
SEC61A1 -7144
SRPRB -7038
SEC61B -6986
RPL36 -6927
SRP68 -6916
SRP54 -6895
RPS3 -6819
RPL18 -6766
RPL39 -6686

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SSR4 -8245
SSR2 -7984
RPLP0 -7891
SRPRA -7742
RPS19 -7713
RPL3 -7686
RPS2 -7641
DDOST -7516
RPL28 -7343
RPN1 -7287
RPS29 -7209
SEC61A1 -7144
SRPRB -7038
SEC61B -6986
RPL36 -6927
SRP68 -6916
SRP54 -6895
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
SSR1 -6102
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPN2 -5569
RPL38 -5491
RPS16 -5397
SSR3 -5324
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
SEC11A -2831
SEC61G -2799
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
SPCS3 -1847
RPS14 -1548
RPL36A -1431
SRP72 -905
SRP14 -847
SPCS2 -789
RPS4Y1 -434
SEC11C -280
SRP19 755
RPS26 851
TRAM1 852
SPCS1 3076
SEC61A2 5235
SRP9 5603


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
737
set NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize 12
pANOVA 0.00147
s.dist 0.53
p.adjustANOVA 0.00691



Top enriched genes

Top 20 genes
GeneID Gene Rank
IKBKB 8151
TRIM25 8017
CASP10 7076
RNF135 7019
IFIH1 6763
CASP8 5048
MAVS 4991
IKBKG 3657
CHUK 3447
TRIM4 2902
RIPK1 766
FADD -5903

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IKBKB 8151
TRIM25 8017
CASP10 7076
RNF135 7019
IFIH1 6763
CASP8 5048
MAVS 4991
IKBKG 3657
CHUK 3447
TRIM4 2902
RIPK1 766
FADD -5903


Selenocysteine synthesis

Selenocysteine synthesis
1146
set Selenocysteine synthesis
setSize 91
pANOVA 2.7e-18
s.dist -0.529
p.adjustANOVA 1.47e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
SARS1 -6439
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
SARS1 -6439
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
SEPHS2 -2669
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
PSTK -1922
RPS14 -1548
RPL36A -1431
EEFSEC -583
RPS4Y1 -434
RPS26 851
SECISBP2 7132
SEPSECS 7682


Suppression of phagosomal maturation

Suppression of phagosomal maturation
1262
set Suppression of phagosomal maturation
setSize 13
pANOVA 0.000979
s.dist -0.528
p.adjustANOVA 0.00487



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOS2 -7912
UBB -7624
UBC -7582
ATP6V1H -7501
UBA52 -6597
RAB5A -5527
KPNB1 -5490
CORO1A -5479
VPS33B -4696
RPS27A -2686
HGS -1983
RAB7A -1650
KPNA1 6323

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOS2 -7912
UBB -7624
UBC -7582
ATP6V1H -7501
UBA52 -6597
RAB5A -5527
KPNB1 -5490
CORO1A -5479
VPS33B -4696
RPS27A -2686
HGS -1983
RAB7A -1650
KPNA1 6323


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
625
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 109
pANOVA 1.67e-21
s.dist -0.528
p.adjustANOVA 2.05e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496
RPL19 -6464

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496
RPL19 -6464
EIF3B -6355
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
EIF3G -5696
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
EIF2S1 -5255
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
EIF3H -4971
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
EIF3A -4296
RPS10 -4241
RPL6 -4135
EIF3F -4130
EIF3K -4108
RPL15 -4083
RPS13 -4077
RPL36AL -3945
EIF3L -3920
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
EIF4B -2967
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
EIF3D -1816
RPS14 -1548
EIF3J -1514
RPL36A -1431
EIF2S3 -1428
EIF3E -1084
EIF4E -626
RPS4Y1 -434
RPS26 851
EIF3M 1103
EIF4A2 1907
PABPC1 2772
EIF1AX 6869


Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis
187
set Chondroitin sulfate biosynthesis
setSize 16
pANOVA 0.000293
s.dist -0.523
p.adjustANOVA 0.00164



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHSY1 -8321
BGN -8013
CHPF -7970
CHSY3 -7843
CHPF2 -7355
CHST3 -6839
CSGALNACT2 -6646
CSPG4 -6110
CHST11 -6072
CSGALNACT1 -3878
DCN -2719
CHST15 -1427
VCAN -370
CHST7 552
CHST12 732
CHST13 1089

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHSY1 -8321
BGN -8013
CHPF -7970
CHSY3 -7843
CHPF2 -7355
CHST3 -6839
CSGALNACT2 -6646
CSPG4 -6110
CHST11 -6072
CSGALNACT1 -3878
DCN -2719
CHST15 -1427
VCAN -370
CHST7 552
CHST12 732
CHST13 1089


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
462
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 110
pANOVA 4.06e-21
s.dist -0.52
p.adjustANOVA 4.6e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496
RPL19 -6464

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496
RPL19 -6464
EIF3B -6355
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
EIF3G -5696
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
EIF2S1 -5255
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
EIF3H -4971
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
EIF3A -4296
RPS10 -4241
RPL6 -4135
EIF3F -4130
EIF3K -4108
RPL15 -4083
RPS13 -4077
RPL36AL -3945
EIF3L -3920
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
EIF4B -2967
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
EIF3D -1816
RPS14 -1548
EIF3J -1514
RPL36A -1431
EIF2S3 -1428
EIF3E -1084
EIF4E -626
RPS4Y1 -434
RPS26 851
EIF3M 1103
EIF5 1512
EIF4A2 1907
EIF5B 3636
EIF1AX 6869


Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases
41
set Activation of Matrix Metalloproteinases
setSize 23
pANOVA 1.61e-05
s.dist -0.52
p.adjustANOVA 0.000113



Top enriched genes

Top 20 genes
GeneID Gene Rank
MMP25 -8415
FURIN -8373
MMP13 -8337
MMP8 -8334
CTSK -8215
MMP11 -8077
MMP7 -8023
MMP14 -7663
ELANE -7565
TIMP1 -7481
MMP2 -7197
CTSG -6676
TPSAB1 -5743
MMP17 -3627
MMP9 -3492
TIMP2 -2923
COL18A1 -2477
MMP24 -1649
MMP16 -138
MMP3 140

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMP25 -8415
FURIN -8373
MMP13 -8337
MMP8 -8334
CTSK -8215
MMP11 -8077
MMP7 -8023
MMP14 -7663
ELANE -7565
TIMP1 -7481
MMP2 -7197
CTSG -6676
TPSAB1 -5743
MMP17 -3627
MMP9 -3492
TIMP2 -2923
COL18A1 -2477
MMP24 -1649
MMP16 -138
MMP3 140
MMP1 248
MMP15 4756
KLKB1 7615


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1086
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 99
pANOVA 6.14e-19
s.dist -0.517
p.adjustANOVA 3.48e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATF3 -8371
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
ATF4 -7427
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF3 -8371
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
ATF4 -7427
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
RPL27A -6629
UBA52 -6597
RPL10 -6551
RPL41 -6496
RPL19 -6464
RPL37 -6352
RPL8 -6270
CEBPB -6235
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
TRIB3 -5395
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
EIF2S1 -5255
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
RPL6 -4135
RPL15 -4083
RPS13 -4077
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
DDIT3 -2931
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
RPS14 -1548
RPL36A -1431
EIF2S3 -1428
RPS4Y1 -434
RPS26 851
GCN1 902
IMPACT 2361
CEBPG 3606
ATF2 4104
ASNS 4575
EIF2AK4 5976


Keratan sulfate degradation

Keratan sulfate degradation
620
set Keratan sulfate degradation
setSize 13
pANOVA 0.00131
s.dist -0.515
p.adjustANOVA 0.00634



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAN -8364
OMD -7768
OGN -7543
LUM -7308
FMOD -7200
PRELP -6737
GNS -3293
KERA -2985
GLB1L -2966
HEXB -2239
GALNS -1076
HEXA 215
GLB1 274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN -8364
OMD -7768
OGN -7543
LUM -7308
FMOD -7200
PRELP -6737
GNS -3293
KERA -2985
GLB1L -2966
HEXB -2239
GALNS -1076
HEXA 215
GLB1 274


Crosslinking of collagen fibrils

Crosslinking of collagen fibrils
230
set Crosslinking of collagen fibrils
setSize 14
pANOVA 0.000902
s.dist -0.512
p.adjustANOVA 0.0045



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL1A1 -7605
LOXL2 -7226
COL1A2 -7023
PXDN -6680
LOX -6328
PCOLCE -5694
LOXL4 -5562
LOXL3 -4802
TLL1 -4604
COL4A2 -4395
COL4A1 -2499
LOXL1 -2004
BMP1 -1477
COL4A5 4829

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL1A1 -7605
LOXL2 -7226
COL1A2 -7023
PXDN -6680
LOX -6328
PCOLCE -5694
LOXL4 -5562
LOXL3 -4802
TLL1 -4604
COL4A2 -4395
COL4A1 -2499
LOXL1 -2004
BMP1 -1477
COL4A5 4829


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
151
set Cap-dependent Translation Initiation
setSize 117
pANOVA 1.19e-21
s.dist -0.511
p.adjustANOVA 1.59e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF4EBP1 -7488
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF4EBP1 -7488
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496
RPL19 -6464
EIF3B -6355
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
EIF2B2 -5837
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
EIF3G -5696
RPL23 -5667
EIF2B3 -5631
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
EIF2S1 -5255
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
EIF2B4 -5119
RPL39L -5101
RPS6 -5018
RPL5 -5006
EIF3H -4971
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
EIF3A -4296
RPS10 -4241
RPL6 -4135
EIF3F -4130
EIF3K -4108
RPL15 -4083
RPS13 -4077
RPL36AL -3945
EIF3L -3920
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
EIF4B -2967
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
EIF3D -1816
EIF2B1 -1712
RPS14 -1548
EIF3J -1514
RPL36A -1431
EIF2S3 -1428
EIF3E -1084
EIF4E -626
RPS4Y1 -434
RPS26 851
EIF2B5 992
EIF3M 1103
EIF5 1512
EIF4A2 1907
PABPC1 2772
EIF5B 3636
EIF1AX 6869


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
371
set Eukaryotic Translation Initiation
setSize 117
pANOVA 1.19e-21
s.dist -0.511
p.adjustANOVA 1.59e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF4EBP1 -7488
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
EIF4EBP1 -7488
EIF3I -7463
RPL28 -7343
RPS29 -7209
EIF2S2 -6998
RPL36 -6927
RPS3 -6819
RPL18 -6766
EIF4G1 -6700
RPL39 -6686
EIF4A1 -6650
RPL27A -6629
UBA52 -6597
EIF4H -6563
RPL10 -6551
RPL41 -6496
RPL19 -6464
EIF3B -6355
RPL37 -6352
RPL8 -6270
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
EIF2B2 -5837
RPL18A -5814
RPL17 -5781
RPS12 -5766
RPS21 -5750
RPL13 -5738
EIF3G -5696
RPL23 -5667
EIF2B3 -5631
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
RPL4 -5262
EIF2S1 -5255
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
EIF2B4 -5119
RPL39L -5101
RPS6 -5018
RPL5 -5006
EIF3H -4971
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
EIF3A -4296
RPS10 -4241
RPL6 -4135
EIF3F -4130
EIF3K -4108
RPL15 -4083
RPS13 -4077
RPL36AL -3945
EIF3L -3920
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
EIF4B -2967
RPL22 -2914
RPL14 -2783
RPL24 -2780
RPS27A -2686
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
EIF3D -1816
EIF2B1 -1712
RPS14 -1548
EIF3J -1514
RPL36A -1431
EIF2S3 -1428
EIF3E -1084
EIF4E -626
RPS4Y1 -434
RPS26 851
EIF2B5 992
EIF3M 1103
EIF5 1512
EIF4A2 1907
PABPC1 2772
EIF5B 3636
EIF1AX 6869


ATF6 (ATF6-alpha) activates chaperones

ATF6 (ATF6-alpha) activates chaperones
21
set ATF6 (ATF6-alpha) activates chaperones
setSize 12
pANOVA 0.00223
s.dist -0.51
p.adjustANOVA 0.01



Top enriched genes

Top 20 genes
GeneID Gene Rank
CALR -7915
XBP1 -7678
ATF4 -7427
HSP90B1 -6390
MBTPS2 -6278
HSPA5 -5540
MBTPS1 -5260
NFYC -3992
ATF6 -3883
DDIT3 -2931
NFYA 7
NFYB 5189

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CALR -7915
XBP1 -7678
ATF4 -7427
HSP90B1 -6390
MBTPS2 -6278
HSPA5 -5540
MBTPS1 -5260
NFYC -3992
ATF6 -3883
DDIT3 -2931
NFYA 7
NFYB 5189


The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint
1336
set The role of GTSE1 in G2/M progression after G2 checkpoint
setSize 70
pANOVA 1.95e-13
s.dist -0.508
p.adjustANOVA 6.66e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB1 -8378
CDKN1A -8342
TUBA4A -8303
PSMB5 -7965
PSMD8 -7921
UBB -7624
TUBA8 -7620
UBC -7582
PSMD3 -7480
PSMD9 -7386
PSMB7 -7117
TUBB2A -7115
PSMB4 -7037
PSMB6 -6917
PSMA5 -6910
PSMD13 -6893
TUBB2B -6815
TUBB3 -6598
UBA52 -6597
TP53 -6483

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB1 -8378
CDKN1A -8342
TUBA4A -8303
PSMB5 -7965
PSMD8 -7921
UBB -7624
TUBA8 -7620
UBC -7582
PSMD3 -7480
PSMD9 -7386
PSMB7 -7117
TUBB2A -7115
PSMB4 -7037
PSMB6 -6917
PSMA5 -6910
PSMD13 -6893
TUBB2B -6815
TUBB3 -6598
UBA52 -6597
TP53 -6483
PSMD4 -6422
PSMC4 -6358
PSMD14 -6161
TUBB4B -5898
PSMB3 -5834
PSMD2 -5813
PSME3 -5779
PSMC3 -5689
PSMF1 -5641
PSMD1 -5563
TUBA1C -5471
PSMA7 -5396
PSMD11 -5049
CCNB2 -4988
SEM1 -4495
PSMC5 -4340
HSP90AB1 -4263
PSME2 -4227
PSME1 -4207
TUBB6 -4118
PSMB9 -4098
TUBA1B -3972
PSMD7 -3784
PSMB2 -3625
PSMA4 -3491
PSMC1 -3408
MAPRE1 -3322
PSMA2 -2957
CCNB1 -2814
PLK1 -2735
RPS27A -2686
PSMA1 -2611
PSMD5 -2546
TUBA1A -2543
PSMD10 -2427
FKBPL -2080
PSME4 -1789
GTSE1 -1661
PSMD12 -1659
HSP90AA1 -1568
PSMB8 -1549
PSMB10 -1521
TUBAL3 -1466
PSMB1 -1193
PSMC2 264
PSMA6 597
PSMD6 664
CDK1 1928
PSMA3 2875
PSMC6 6135


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
406
set Formation of ATP by chemiosmotic coupling
setSize 16
pANOVA 0.000509
s.dist -0.502
p.adjustANOVA 0.00269



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5F1B -7774
ATP5ME -7752
ATP5F1A -6886
ATP5MC3 -6852
ATP5F1E -6399
ATP5MC1 -5875
ATP5MC2 -5470
ATP5MG -5171
ATP5PF -5034
ATP5MF -4836
ATP5F1D -4608
ATP5PD -2297
ATP5PB -1529
ATP5F1C -1025
ATP5PO -562
DMAC2L 3684

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5F1B -7774
ATP5ME -7752
ATP5F1A -6886
ATP5MC3 -6852
ATP5F1E -6399
ATP5MC1 -5875
ATP5MC2 -5470
ATP5MG -5171
ATP5PF -5034
ATP5MF -4836
ATP5F1D -4608
ATP5PD -2297
ATP5PB -1529
ATP5F1C -1025
ATP5PO -562
DMAC2L 3684


Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D
1409
set Ubiquitin-dependent degradation of Cyclin D
setSize 50
pANOVA 1.02e-09
s.dist -0.499
p.adjustANOVA 2.06e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB5 -7965
PSMD8 -7921
UBB -7624
UBC -7582
PSMD3 -7480
PSMD9 -7386
PSMB7 -7117
PSMB4 -7037
CDK4 -7026
PSMB6 -6917
PSMA5 -6910
PSMD13 -6893
UBA52 -6597
CCND1 -6574
PSMD4 -6422
PSMC4 -6358
PSMD14 -6161
PSMB3 -5834
PSMD2 -5813
PSME3 -5779

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB5 -7965
PSMD8 -7921
UBB -7624
UBC -7582
PSMD3 -7480
PSMD9 -7386
PSMB7 -7117
PSMB4 -7037
CDK4 -7026
PSMB6 -6917
PSMA5 -6910
PSMD13 -6893
UBA52 -6597
CCND1 -6574
PSMD4 -6422
PSMC4 -6358
PSMD14 -6161
PSMB3 -5834
PSMD2 -5813
PSME3 -5779
PSMC3 -5689
PSMF1 -5641
PSMD1 -5563
PSMA7 -5396
PSMD11 -5049
SEM1 -4495
PSMC5 -4340
PSME2 -4227
PSME1 -4207
PSMB9 -4098
PSMD7 -3784
PSMB2 -3625
PSMA4 -3491
PSMC1 -3408
PSMA2 -2957
RPS27A -2686
PSMA1 -2611
PSMD5 -2546
PSMD10 -2427
PSME4 -1789
PSMD12 -1659
PSMB8 -1549
PSMB10 -1521
GSK3B -1282
PSMB1 -1193
PSMC2 264
PSMA6 597
PSMD6 664
PSMA3 2875
PSMC6 6135


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
424
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 7.02e-10
s.dist -0.499
p.adjustANOVA 1.5e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS19 -7713
RPS2 -7641
EIF3I -7463
RPS29 -7209
EIF2S2 -6998
RPS3 -6819
EIF3B -6355
RPS18 -6137
RPS27 -6115
RPSA -6061
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPS15 -5859
RPS12 -5766
RPS21 -5750
EIF3G -5696
RPS16 -5397

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS19 -7713
RPS2 -7641
EIF3I -7463
RPS29 -7209
EIF2S2 -6998
RPS3 -6819
EIF3B -6355
RPS18 -6137
RPS27 -6115
RPSA -6061
RPS28 -6047
EIF3C -5977
FAU -5935
RPS8 -5932
RPS5 -5915
RPS15 -5859
RPS12 -5766
RPS21 -5750
EIF3G -5696
RPS16 -5397
EIF2S1 -5255
RPS4X -5190
RPS11 -5164
RPS9 -5156
RPS6 -5018
EIF3H -4971
RPS17 -4895
RPS25 -4561
RPS15A -4397
EIF3A -4296
RPS10 -4241
EIF3F -4130
EIF3K -4108
RPS13 -4077
EIF3L -3920
RPS27L -3846
RPS23 -3513
RPS24 -3505
RPS7 -3126
RPS27A -2686
RPS3A -2257
RPS20 -2207
EIF3D -1816
RPS14 -1548
EIF3J -1514
EIF2S3 -1428
EIF3E -1084
RPS4Y1 -434
RPS26 851
EIF3M 1103
EIF1AX 6869


Selenoamino acid metabolism

Selenoamino acid metabolism
1145
set Selenoamino acid metabolism
setSize 113
pANOVA 6.11e-20
s.dist -0.498
p.adjustANOVA 4.49e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
NNMT -8359
IARS1 -8069
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
PAPSS1 -6632
RPL27A -6629
UBA52 -6597
RPL10 -6551
GSR -6531
PAPSS2 -6522
RPL41 -6496
RPL19 -6464

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NNMT -8359
IARS1 -8069
RPLP0 -7891
RPS19 -7713
RPL3 -7686
RPS2 -7641
RPL28 -7343
RPS29 -7209
RPL36 -6927
RPS3 -6819
RPL18 -6766
RPL39 -6686
PAPSS1 -6632
RPL27A -6629
UBA52 -6597
RPL10 -6551
GSR -6531
PAPSS2 -6522
RPL41 -6496
RPL19 -6464
SARS1 -6439
RPL37 -6352
RPL8 -6270
AHCY -6266
EPRS1 -6259
RPS18 -6137
RPS27 -6115
RPL10A -6065
RPSA -6061
RPL37A -6055
RPS28 -6047
FAU -5935
RPS8 -5932
RPS5 -5915
RPLP1 -5910
RPS15 -5859
RPL18A -5814
RPL17 -5781
RPS12 -5766
KARS1 -5754
RPS21 -5750
RPL13 -5738
RPL23 -5667
RPL12 -5612
RPL38 -5491
RPS16 -5397
RPL29 -5304
RPL26L1 -5277
MARS1 -5275
RPL4 -5262
RPL11 -5228
RPS4X -5190
RPS11 -5164
RPS9 -5156
CBS -5110
RPL39L -5101
RPS6 -5018
RPL5 -5006
RPS17 -4895
RPL13A -4781
RPLP2 -4734
RPL7A -4579
RPS25 -4561
RPL32 -4542
RPL35 -4472
RPS15A -4397
RPL27 -4324
RPS10 -4241
CTH -4216
RPL6 -4135
RPL15 -4083
RPS13 -4077
DARS1 -4015
RPL36AL -3945
RPS27L -3846
RPL34 -3631
RPL31 -3604
RPS23 -3513
RPS24 -3505
RPL30 -3369
RPL26 -3362
RPL35A -3274
RPL22L1 -3218
RPS7 -3126
TXNRD1 -3009
RPL22 -2914
RARS1 -2859
SCLY -2832
RPL14 -2783
RPL24 -2780
RPS27A -2686
SEPHS2 -2669
EEF1E1 -2643
RPL21 -2556
RPL23A -2408
RPL7 -2349
RPL9 -2284
RPS3A -2257
RPS20 -2207
PSTK -1922
RPS14 -1548
RPL36A -1431
AIMP2 -1306
QARS1 -959
EEFSEC -583
RPS4Y1 -434
RPS26 851
INMT 1205
LARS1 4115
AIMP1 4650
SECISBP2 7132
SEPSECS 7682
HNMT 7964


Diseases associated with glycosaminoglycan metabolism

Diseases associated with glycosaminoglycan metabolism
303
set Diseases associated with glycosaminoglycan metabolism
setSize 38
pANOVA 1.11e-07
s.dist -0.497
p.adjustANOVA 1.26e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAN -8364
CHSY1 -8321
SDC4 -8048
BGN -8013
CHST6 -7948
OMD -7768
OGN -7543
ST3GAL3 -7316
LUM -7308
FMOD -7200
B4GALT1 -7195
CHST3 -6839
PRELP -6737
SDC1 -6611
PAPSS2 -6522
GPC1 -6200
B4GALT7 -6121
CSPG4 -6110
CHST14 -6039
GPC4 -5879

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN -8364
CHSY1 -8321
SDC4 -8048
BGN -8013
CHST6 -7948
OMD -7768
OGN -7543
ST3GAL3 -7316
LUM -7308
FMOD -7200
B4GALT1 -7195
CHST3 -6839
PRELP -6737
SDC1 -6611
PAPSS2 -6522
GPC1 -6200
B4GALT7 -6121
CSPG4 -6110
CHST14 -6039
GPC4 -5879
EXT2 -5388
B3GALT6 -4999
B3GAT3 -4856
GPC2 -4119
EXT1 -3061
KERA -2985
GPC3 -2869
DCN -2719
HEXB -2239
GPC6 -2035
VCAN -370
SDC3 35
HEXA 215
SLC26A2 1922
HSPG2 2113
AGRN 2896
GPC5 4797
SDC2 4937


Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
1061
set Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
setSize 10
pANOVA 0.0066
s.dist -0.496
p.adjustANOVA 0.0255



Top enriched genes

Top 20 genes
GeneID Gene Rank
PFKFB3 -7602
PFKFB4 -7348
PRKACA -6997
PPP2CA -6608
PPP2R1A -6444
PPP2R1B -5899
PPP2CB -3850
PPP2R5D -3521
PFKFB2 1523
PRKACB 4470

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PFKFB3 -7602
PFKFB4 -7348
PRKACA -6997
PPP2CA -6608
PPP2R1A -6444
PPP2R1B -5899
PPP2CB -3850
PPP2R5D -3521
PFKFB2 1523
PRKACB 4470


FGFR2 ligand binding and activation

FGFR2 ligand binding and activation
387
set FGFR2 ligand binding and activation
setSize 10
pANOVA 0.00697
s.dist -0.493
p.adjustANOVA 0.0267



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF1 -8390
FGFR2 -7930
FGF9 -7159
FGF18 -6599
FGF23 -6140
FGF7 -5852
FGF2 -4492
FGFBP2 -1081
FGFBP3 782
FGF10 4867

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF1 -8390
FGFR2 -7930
FGF9 -7159
FGF18 -6599
FGF23 -6140
FGF7 -5852
FGF2 -4492
FGFBP2 -1081
FGFBP3 782
FGF10 4867


Downregulation of ERBB2:ERBB3 signaling

Downregulation of ERBB2:ERBB3 signaling
321
set Downregulation of ERBB2:ERBB3 signaling
setSize 13
pANOVA 0.00211
s.dist -0.492
p.adjustANOVA 0.00955



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKT1 -7935
RNF41 -7916
UBB -7624
UBC -7582
NRG2 -7177
UBA52 -6597
ERBB2 -3246
RPS27A -2686
NRG1 -2384
AKT2 -2374
AKT3 -2058
ERBB3 -1444
USP8 4473

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKT1 -7935
RNF41 -7916
UBB -7624
UBC -7582
NRG2 -7177
UBA52 -6597
ERBB2 -3246
RPS27A -2686
NRG1 -2384
AKT2 -2374
AKT3 -2058
ERBB3 -1444
USP8 4473


Response of EIF2AK1 (HRI) to heme deficiency

Response of EIF2AK1 (HRI) to heme deficiency
1085
set Response of EIF2AK1 (HRI) to heme deficiency
setSize 14
pANOVA 0.00144
s.dist -0.492
p.adjustANOVA 0.00687



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATF3 -8371
PPP1R15A -8302
EIF2AK1 -7490
ATF4 -7427
EIF2S2 -6998
ATF5 -6882
CEBPB -6235
TRIB3 -5395
EIF2S1 -5255
DDIT3 -2931
EIF2S3 -1428
GRB10 -145
CEBPG 3606
ASNS 4575

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF3 -8371
PPP1R15A -8302
EIF2AK1 -7490
ATF4 -7427
EIF2S2 -6998
ATF5 -6882
CEBPB -6235
TRIB3 -5395
EIF2S1 -5255
DDIT3 -2931
EIF2S3 -1428
GRB10 -145
CEBPG 3606
ASNS 4575


Membrane binding and targetting of GAG proteins

Membrane binding and targetting of GAG proteins
673
set Membrane binding and targetting of GAG proteins
setSize 14
pANOVA 0.00145
s.dist -0.491
p.adjustANOVA 0.00687



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS37B -7749
UBB -7624
UBC -7582
UBA52 -6597
VPS37A -6504
VPS37D -5978
UBAP1 -5775
VPS37C -4775
TSG101 -3035
RPS27A -2686
MVB12A -2524
VPS28 -1060
MVB12B -1050
NMT2 4311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS37B -7749
UBB -7624
UBC -7582
UBA52 -6597
VPS37A -6504
VPS37D -5978
UBAP1 -5775
VPS37C -4775
TSG101 -3035
RPS27A -2686
MVB12A -2524
VPS28 -1060
MVB12B -1050
NMT2 4311


Synthesis And Processing Of GAG, GAGPOL Polyproteins

Synthesis And Processing Of GAG, GAGPOL Polyproteins
1267
set Synthesis And Processing Of GAG, GAGPOL Polyproteins
setSize 14
pANOVA 0.00145
s.dist -0.491
p.adjustANOVA 0.00687



Top enriched genes

Top 20 genes
GeneID Gene Rank
VPS37B -7749
UBB -7624
UBC -7582
UBA52 -6597
VPS37A -6504
VPS37D -5978
UBAP1 -5775
VPS37C -4775
TSG101 -3035
RPS27A -2686
MVB12A -2524
VPS28 -1060
MVB12B -1050
NMT2 4311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VPS37B -7749
UBB -7624
UBC -7582
UBA52 -6597
VPS37A -6504
VPS37D -5978
UBAP1 -5775
VPS37C -4775
TSG101 -3035
RPS27A -2686
MVB12A -2524
VPS28 -1060
MVB12B -1050
NMT2 4311


Keratan sulfate/keratin metabolism

Keratan sulfate/keratin metabolism
621
set Keratan sulfate/keratin metabolism
setSize 32
pANOVA 1.58e-06
s.dist -0.49
p.adjustANOVA 1.3e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAN -8364
ST3GAL2 -7975
CHST6 -7948
OMD -7768
B4GALT3 -7638
OGN -7543
B4GALT5 -7319
ST3GAL3 -7316
CHST1 -7309
LUM -7308
ST3GAL1 -7307
FMOD -7200
B4GALT1 -7195
B4GALT2 -6989
PRELP -6737
B4GALT4 -6720
ST3GAL4 -6387
B4GALT6 -5564
CHST5 -4724
B3GNT7 -3337

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN -8364
ST3GAL2 -7975
CHST6 -7948
OMD -7768
B4GALT3 -7638
OGN -7543
B4GALT5 -7319
ST3GAL3 -7316
CHST1 -7309
LUM -7308
ST3GAL1 -7307
FMOD -7200
B4GALT1 -7195
B4GALT2 -6989
PRELP -6737
B4GALT4 -6720
ST3GAL4 -6387
B4GALT6 -5564
CHST5 -4724
B3GNT7 -3337
GNS -3293
KERA -2985
GLB1L -2966
HEXB -2239
B4GAT1 -1389
GALNS -1076
HEXA 215
GLB1 274
SLC35D2 1766
CHST2 3767
ST3GAL6 6384
B3GNT2 6610


Diseases associated with glycosylation precursor biosynthesis

Diseases associated with glycosylation precursor biosynthesis
304
set Diseases associated with glycosylation precursor biosynthesis
setSize 15
pANOVA 0.00102
s.dist -0.49
p.adjustANOVA 0.00503



Top enriched genes

Top 20 genes
GeneID Gene Rank
PGM1 -8126
GALE -7608
GFPT1 -7478
DPM2 -7132
GALK1 -6827
DHDDS -6743
PMM2 -6182
GNE -5686
DPM3 -4884
DOLK -4512
MPI -3156
NUS1 -3073
SRD5A3 1170
DPM1 3703
GALT 3901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PGM1 -8126
GALE -7608
GFPT1 -7478
DPM2 -7132
GALK1 -6827
DHDDS -6743
PMM2 -6182
GNE -5686
DPM3 -4884
DOLK -4512
MPI -3156
NUS1 -3073
SRD5A3 1170
DPM1 3703
GALT 3901


Regulation of RUNX3 expression and activity

Regulation of RUNX3 expression and activity
1044
set Regulation of RUNX3 expression and activity
setSize 55
pANOVA 4.18e-10
s.dist -0.487
p.adjustANOVA 9.45e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSMB5 -7965
PSMD8 -7921
TGFB1 -7715
UBB -7624
UBC -7582
PSMD3 -7480
SMURF1 -7435
SRC -7389
PSMD9 -7386
RUNX3 -7378
PSMB7 -7117
PSMB4 -7037
PSMB6 -6917
PSMA5 -6910
PSMD13 -6893
UBA52 -6597
PSMD4 -6422
PSMC4 -6358
PSMD14 -6161
PSMB3 -5834

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSMB5 -7965
PSMD8 -7921
TGFB1 -7715
UBB -7624
UBC -7582
PSMD3 -7480
SMURF1 -7435
SRC -7389
PSMD9 -7386
RUNX3 -7378
PSMB7 -7117
PSMB4 -7037
PSMB6 -6917
PSMA5 -6910
PSMD13 -6893
UBA52 -6597
PSMD4 -6422
PSMC4 -6358
PSMD14 -6161
PSMB3 -5834
PSMD2 -5813
PSME3 -5779
PSMC3 -5689
PSMF1 -5641
PSMD1 -5563
PSMA7 -5396
PSMD11 -5049
CDKN2A -4644
SEM1 -4495
MDM2 -4394
PSMC5 -4340
PSME2 -4227
PSME1 -4207
PSMB9 -4098
PSMD7 -3784
PSMB2 -3625
PSMA4 -3491
PSMC1 -3408
PSMA2 -2957
RPS27A -2686
PSMA1 -2611
PSMD5 -2546
PSMD10 -2427
CBFB -1713
PSMD12 -1659
PSMB8 -1549
PSMB10 -1521
PSMB1 -1193
PSMC2 264
PSMA6 597
PSMD6 664
EP300 2823
PSMA3 2875
SMURF2 5575
PSMC6 6135


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               zlibbioc_1.48.0         cachem_1.0.8           
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.8             
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report