date generated: 2024-02-26

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 3.8928494
7SK 0.4717721
A1BG 1.6651353
A1BG.AS1 0.1794742
A2M 0.7123567
A2M.AS1 1.0831002

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 16432
duplicated_genes_present 0
num_profile_genes_in_sets 8188
num_profile_genes_not_in_sets 8244

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1148
num_genesets_included 1464

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Eukaryotic Translation Elongation 91 1.75e-32 0.719 5.13e-30
Peptide chain elongation 87 1.19e-30 0.713 1.75e-28
Viral mRNA Translation 87 4.76e-30 0.705 6.34e-28
Formation of a pool of free 40S subunits 99 4.49e-32 0.685 8.21e-30
SARS-CoV-1 modulates host translation machinery 36 1.35e-12 0.682 4.60e-11
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.43e-29 0.677 1.74e-27
Eukaryotic Translation Termination 91 1.13e-28 0.673 1.18e-26
Formation of tubulin folding intermediates by CCT/TriC 20 2.11e-07 0.670 3.40e-06
Selenocysteine synthesis 91 3.37e-28 0.667 2.90e-26
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.15e-33 0.667 1.05e-30
GTP hydrolysis and joining of the 60S ribosomal subunit 110 7.05e-33 0.658 2.58e-30
Folding of actin by CCT/TriC 10 3.84e-04 0.648 2.67e-03
SRP-dependent cotranslational protein targeting to membrane 110 1.21e-31 0.645 1.96e-29
Prefoldin mediated transfer of substrate to CCT/TriC 24 6.78e-08 0.636 1.38e-06
Formation of the ternary complex, and subsequently, the 43S complex 51 4.10e-15 0.635 1.54e-13
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.17e-27 0.633 9.49e-26
Cap-dependent Translation Initiation 117 3.73e-32 0.631 7.80e-30
Eukaryotic Translation Initiation 117 3.73e-32 0.631 7.80e-30
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.57e-04 0.630 1.21e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 1.56e-08 0.629 3.81e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.82e-16 0.615 1.18e-14
Translation initiation complex formation 58 8.92e-16 0.610 3.53e-14
Ribosomal scanning and start codon recognition 58 1.34e-15 0.606 5.17e-14
Josephin domain DUBs 10 9.34e-04 0.604 5.88e-03
Selenoamino acid metabolism 113 1.56e-28 0.603 1.52e-26
Glycogen synthesis 12 4.83e-04 0.582 3.27e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 4.79e-25 0.562 3.19e-23
Nonsense-Mediated Decay (NMD) 113 4.79e-25 0.562 3.19e-23
TP53 Regulates Transcription of Death Receptors and Ligands 10 2.52e-03 0.552 1.40e-02
Transport of connexons to the plasma membrane 13 6.92e-04 0.543 4.52e-03
SARS-CoV-2 modulates host translation machinery 49 1.07e-10 0.533 3.48e-09
Regulation of expression of SLITs and ROBOs 162 4.60e-29 0.509 5.19e-27
Downregulation of ERBB2:ERBB3 signaling 13 1.50e-03 0.508 8.73e-03
Keratan sulfate biosynthesis 26 9.09e-06 0.503 9.17e-05
Membrane binding and targetting of GAG proteins 14 1.25e-03 0.498 7.47e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.25e-03 0.498 7.47e-03
E3 ubiquitin ligases ubiquitinate target proteins 43 1.68e-08 0.497 4.03e-07
Diseases associated with glycosaminoglycan metabolism 38 3.78e-07 0.476 5.33e-06
Chondroitin sulfate biosynthesis 16 1.04e-03 0.474 6.37e-03
Ubiquitin-dependent degradation of Cyclin D 50 1.11e-08 0.467 2.86e-07
Pexophagy 11 7.34e-03 0.467 3.61e-02
ABC transporters in lipid homeostasis 12 5.18e-03 -0.466 2.72e-02
Assembly Of The HIV Virion 16 1.28e-03 0.465 7.62e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 7.88e-03 0.463 3.82e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 6.33e-03 -0.455 3.15e-02
Cellular response to starvation 148 2.05e-21 0.452 1.11e-19
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 5.92e-08 0.452 1.22e-06
The role of GTSE1 in G2/M progression after G2 checkpoint 69 8.45e-11 0.452 2.81e-09
HSF1 activation 25 1.04e-04 0.449 8.19e-04
Translation 290 2.82e-39 0.447 4.13e-36


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Eukaryotic Translation Elongation 91 1.75e-32 0.719000 5.13e-30
Peptide chain elongation 87 1.19e-30 0.713000 1.75e-28
Viral mRNA Translation 87 4.76e-30 0.705000 6.34e-28
Formation of a pool of free 40S subunits 99 4.49e-32 0.685000 8.21e-30
SARS-CoV-1 modulates host translation machinery 36 1.35e-12 0.682000 4.60e-11
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.43e-29 0.677000 1.74e-27
Eukaryotic Translation Termination 91 1.13e-28 0.673000 1.18e-26
Formation of tubulin folding intermediates by CCT/TriC 20 2.11e-07 0.670000 3.40e-06
Selenocysteine synthesis 91 3.37e-28 0.667000 2.90e-26
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.15e-33 0.667000 1.05e-30
GTP hydrolysis and joining of the 60S ribosomal subunit 110 7.05e-33 0.658000 2.58e-30
Folding of actin by CCT/TriC 10 3.84e-04 0.648000 2.67e-03
SRP-dependent cotranslational protein targeting to membrane 110 1.21e-31 0.645000 1.96e-29
Prefoldin mediated transfer of substrate to CCT/TriC 24 6.78e-08 0.636000 1.38e-06
Formation of the ternary complex, and subsequently, the 43S complex 51 4.10e-15 0.635000 1.54e-13
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.17e-27 0.633000 9.49e-26
Cap-dependent Translation Initiation 117 3.73e-32 0.631000 7.80e-30
Eukaryotic Translation Initiation 117 3.73e-32 0.631000 7.80e-30
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.57e-04 0.630000 1.21e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 1.56e-08 0.629000 3.81e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.82e-16 0.615000 1.18e-14
Translation initiation complex formation 58 8.92e-16 0.610000 3.53e-14
Ribosomal scanning and start codon recognition 58 1.34e-15 0.606000 5.17e-14
Josephin domain DUBs 10 9.34e-04 0.604000 5.88e-03
Selenoamino acid metabolism 113 1.56e-28 0.603000 1.52e-26
Glycogen synthesis 12 4.83e-04 0.582000 3.27e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 4.79e-25 0.562000 3.19e-23
Nonsense-Mediated Decay (NMD) 113 4.79e-25 0.562000 3.19e-23
TP53 Regulates Transcription of Death Receptors and Ligands 10 2.52e-03 0.552000 1.40e-02
Transport of connexons to the plasma membrane 13 6.92e-04 0.543000 4.52e-03
SARS-CoV-2 modulates host translation machinery 49 1.07e-10 0.533000 3.48e-09
Regulation of expression of SLITs and ROBOs 162 4.60e-29 0.509000 5.19e-27
Downregulation of ERBB2:ERBB3 signaling 13 1.50e-03 0.508000 8.73e-03
Keratan sulfate biosynthesis 26 9.09e-06 0.503000 9.17e-05
Membrane binding and targetting of GAG proteins 14 1.25e-03 0.498000 7.47e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.25e-03 0.498000 7.47e-03
E3 ubiquitin ligases ubiquitinate target proteins 43 1.68e-08 0.497000 4.03e-07
Diseases associated with glycosaminoglycan metabolism 38 3.78e-07 0.476000 5.33e-06
Chondroitin sulfate biosynthesis 16 1.04e-03 0.474000 6.37e-03
Ubiquitin-dependent degradation of Cyclin D 50 1.11e-08 0.467000 2.86e-07
Pexophagy 11 7.34e-03 0.467000 3.61e-02
ABC transporters in lipid homeostasis 12 5.18e-03 -0.466000 2.72e-02
Assembly Of The HIV Virion 16 1.28e-03 0.465000 7.62e-03
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 7.88e-03 0.463000 3.82e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 6.33e-03 -0.455000 3.15e-02
Cellular response to starvation 148 2.05e-21 0.452000 1.11e-19
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 5.92e-08 0.452000 1.22e-06
The role of GTSE1 in G2/M progression after G2 checkpoint 69 8.45e-11 0.452000 2.81e-09
HSF1 activation 25 1.04e-04 0.449000 8.19e-04
Translation 290 2.82e-39 0.447000 4.13e-36
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 9.13e-08 0.446000 1.76e-06
Influenza Viral RNA Transcription and Replication 134 5.14e-19 0.446000 2.69e-17
Response of EIF2AK1 (HRI) to heme deficiency 14 3.98e-03 0.444000 2.11e-02
PINK1-PRKN Mediated Mitophagy 21 4.50e-04 0.442000 3.09e-03
Aggrephagy 34 8.21e-06 0.442000 8.46e-05
Syndecan interactions 26 9.74e-05 0.442000 7.79e-04
Autodegradation of the E3 ubiquitin ligase COP1 49 9.26e-08 0.441000 1.76e-06
ATF6 (ATF6-alpha) activates chaperones 12 8.25e-03 0.440000 3.92e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 3.31e-08 0.439000 7.57e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.88e-09 0.434000 5.38e-08
Defective CFTR causes cystic fibrosis 58 1.08e-08 0.434000 2.81e-07
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 4.64e-08 0.434000 1.03e-06
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 1.51e-07 0.434000 2.57e-06
p53-Independent DNA Damage Response 49 1.51e-07 0.434000 2.57e-06
p53-Independent G1/S DNA damage checkpoint 49 1.51e-07 0.434000 2.57e-06
Gap junction assembly 20 8.04e-04 0.433000 5.14e-03
Vif-mediated degradation of APOBEC3G 52 7.05e-08 0.432000 1.41e-06
Regulation of ornithine decarboxylase (ODC) 48 2.40e-07 0.431000 3.75e-06
Signaling by ROBO receptors 201 7.20e-26 0.430000 5.27e-24
Major pathway of rRNA processing in the nucleolus and cytosol 179 3.36e-23 0.430000 1.97e-21
ATF6 (ATF6-alpha) activates chaperone genes 10 1.93e-02 0.427000 7.79e-02
Hh mutants are degraded by ERAD 53 7.35e-08 0.427000 1.45e-06
DARPP-32 events 21 7.00e-04 0.427000 4.55e-03
Hh mutants abrogate ligand secretion 55 4.58e-08 0.426000 1.03e-06
Attenuation phase 22 5.54e-04 0.425000 3.72e-03
rRNA processing in the nucleus and cytosol 189 6.77e-24 0.425000 4.31e-22
Negative regulation of NOTCH4 signaling 54 8.44e-08 0.421000 1.65e-06
Vpu mediated degradation of CD4 50 3.42e-07 0.417000 5.06e-06
Assembly and cell surface presentation of NMDA receptors 30 8.12e-05 0.416000 6.57e-04
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 2.18e-07 0.416000 3.47e-06
Free fatty acids regulate insulin secretion 10 2.32e-02 -0.415000 8.89e-02
Regulation of RUNX3 expression and activity 55 1.11e-07 0.414000 2.06e-06
Degradation of DVL 54 1.57e-07 0.413000 2.64e-06
rRNA processing 199 1.33e-23 0.412000 8.14e-22
Suppression of phagosomal maturation 13 1.02e-02 0.411000 4.65e-02
Metabolism of polyamines 56 1.18e-07 0.409000 2.14e-06
Packaging Of Telomere Ends 12 1.41e-02 0.409000 6.10e-02
Synthesis, secretion, and deacylation of Ghrelin 10 2.52e-02 0.409000 9.31e-02
Hedgehog ligand biogenesis 60 4.85e-08 0.407000 1.06e-06
Influenza Infection 153 3.82e-18 0.407000 1.86e-16
PI-3K cascade:FGFR3 12 1.55e-02 0.403000 6.57e-02
Stabilization of p53 54 2.95e-07 0.403000 4.50e-06
Dectin-1 mediated noncanonical NF-kB signaling 58 1.13e-07 0.403000 2.07e-06
Formation of ATP by chemiosmotic coupling 16 5.58e-03 0.400000 2.91e-02
Translesion Synthesis by POLH 18 3.29e-03 0.400000 1.76e-02
Regulation of Apoptosis 51 7.78e-07 0.400000 1.01e-05
Diseases associated with glycosylation precursor biosynthesis 15 7.39e-03 0.400000 3.62e-02
Mucopolysaccharidoses 11 2.21e-02 -0.399000 8.59e-02
PI-3K cascade:FGFR4 11 2.26e-02 0.397000 8.74e-02
Protein ubiquitination 63 5.14e-08 0.397000 1.09e-06
NIK–>noncanonical NF-kB signaling 57 2.41e-07 0.396000 3.75e-06
STAT3 nuclear events downstream of ALK signaling 10 3.09e-02 0.394000 1.09e-01
Cholesterol biosynthesis 26 5.64e-04 0.391000 3.77e-03
Degradation of GLI2 by the proteasome 57 3.51e-07 0.390000 5.08e-06
GLI3 is processed to GLI3R by the proteasome 57 3.78e-07 0.389000 5.33e-06
Cellular response to hypoxia 71 1.97e-08 0.385000 4.65e-07
SHC-mediated cascade:FGFR3 12 2.09e-02 0.385000 8.29e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 69 3.27e-08 0.385000 7.57e-07
SCF-beta-TrCP mediated degradation of Emi1 53 1.48e-06 0.382000 1.80e-05
Budding and maturation of HIV virion 27 5.91e-04 0.382000 3.93e-03
TP53 Regulates Transcription of Caspase Activators and Caspases 10 3.73e-02 -0.380000 1.25e-01
Mitochondrial translation elongation 88 7.03e-10 0.380000 2.10e-08
Negative regulation of FGFR3 signaling 23 1.62e-03 0.380000 9.34e-03
Keratan sulfate/keratin metabolism 32 2.03e-04 0.380000 1.52e-03
Cross-presentation of soluble exogenous antigens (endosomes) 46 8.93e-06 0.379000 9.13e-05
Regulation of BACH1 activity 11 2.98e-02 0.378000 1.07e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 1.13e-02 0.378000 5.04e-02
SHC-mediated cascade:FGFR4 11 3.04e-02 0.377000 1.08e-01
GRB2 events in EGFR signaling 10 3.90e-02 -0.377000 1.29e-01
SCF(Skp2)-mediated degradation of p27/p21 59 5.63e-07 0.377000 7.57e-06
Interleukin-7 signaling 19 4.56e-03 0.376000 2.40e-02
Negative regulation of FGFR4 signaling 22 2.30e-03 0.375000 1.30e-02
N-Glycan antennae elongation 13 1.94e-02 0.375000 7.80e-02
Zinc transporters 10 4.06e-02 0.374000 1.32e-01
Synthesis of PIPs at the Golgi membrane 15 1.25e-02 -0.372000 5.47e-02
TRAF3-dependent IRF activation pathway 13 2.07e-02 -0.371000 8.22e-02
TRAF6 mediated IRF7 activation 15 1.30e-02 -0.370000 5.65e-02
Mitophagy 28 7.24e-04 0.369000 4.69e-03
Degradation of GLI1 by the proteasome 57 1.57e-06 0.368000 1.88e-05
Mitochondrial translation termination 88 2.49e-09 0.368000 7.00e-08
Degradation of AXIN 53 3.67e-06 0.368000 4.07e-05
Interconversion of nucleotide di- and triphosphates 27 1.01e-03 0.366000 6.25e-03
Activation of NF-kappaB in B cells 65 3.55e-07 0.365000 5.09e-06
Degradation of beta-catenin by the destruction complex 82 1.18e-08 0.364000 2.98e-07
NF-kB is activated and signals survival 13 2.30e-02 0.364000 8.85e-02
Platelet Adhesion to exposed collagen 11 3.81e-02 0.361000 1.27e-01
Keratan sulfate degradation 13 2.42e-02 0.361000 9.07e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 30 6.26e-04 0.361000 4.13e-03
Orc1 removal from chromatin 67 3.48e-07 0.360000 5.08e-06
FGFR2 mutant receptor activation 23 2.82e-03 0.360000 1.55e-02
Sealing of the nuclear envelope (NE) by ESCRT-III 23 2.91e-03 0.359000 1.58e-02
Purine catabolism 13 2.54e-02 0.358000 9.34e-02
Mitochondrial translation initiation 88 6.66e-09 0.358000 1.77e-07
Regulation of RUNX2 expression and activity 69 2.91e-07 0.357000 4.48e-06
Downstream TCR signaling 78 5.16e-08 0.357000 1.09e-06
Transcriptional regulation by RUNX3 93 2.90e-09 0.356000 8.01e-08
Asymmetric localization of PCP proteins 61 1.50e-06 0.356000 1.82e-05
Intrinsic Pathway of Fibrin Clot Formation 12 3.27e-02 0.356000 1.13e-01
SLBP independent Processing of Histone Pre-mRNAs 10 5.25e-02 0.354000 1.58e-01
Regulation of PTEN stability and activity 67 5.59e-07 0.354000 7.57e-06
Crosslinking of collagen fibrils 14 2.20e-02 0.354000 8.58e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 4.24e-02 0.353000 1.37e-01
Collagen chain trimerization 36 2.70e-04 0.351000 1.97e-03
Selective autophagy 71 3.23e-07 0.351000 4.83e-06
HSF1-dependent transactivation 31 7.60e-04 0.349000 4.90e-03
Processing and activation of SUMO 10 5.58e-02 0.349000 1.63e-01
Nuclear events mediated by NFE2L2 76 1.42e-07 0.349000 2.51e-06
Mitochondrial translation 94 5.83e-09 0.348000 1.58e-07
Glycogen storage diseases 13 3.08e-02 0.346000 1.09e-01
Collagen biosynthesis and modifying enzymes 58 6.22e-06 0.343000 6.70e-05
Negative regulation of FGFR2 signaling 24 3.77e-03 0.342000 2.01e-02
Smooth Muscle Contraction 35 4.79e-04 0.341000 3.26e-03
Autodegradation of Cdh1 by Cdh1:APC/C 64 2.40e-06 0.341000 2.75e-05
APC/C:Cdc20 mediated degradation of Securin 66 1.71e-06 0.341000 1.98e-05
Integrin cell surface interactions 70 8.73e-07 0.340000 1.12e-05
p53-Dependent G1 DNA Damage Response 62 3.67e-06 0.340000 4.07e-05
p53-Dependent G1/S DNA damage checkpoint 62 3.67e-06 0.340000 4.07e-05
Late endosomal microautophagy 32 9.35e-04 0.338000 5.88e-03
Activation of AMPK downstream of NMDARs 20 9.00e-03 0.337000 4.21e-02
ABC transporter disorders 68 1.64e-06 0.336000 1.92e-05
Regulation of FZD by ubiquitination 15 2.48e-02 0.335000 9.22e-02
TRP channels 20 9.76e-03 -0.334000 4.47e-02
Glycogen metabolism 23 5.72e-03 0.333000 2.94e-02
SHC1 events in EGFR signaling 11 5.61e-02 -0.333000 1.64e-01
PI-3K cascade:FGFR2 13 3.87e-02 0.331000 1.28e-01
MASTL Facilitates Mitotic Progression 10 6.97e-02 0.331000 1.95e-01
Signaling by FGFR2 IIIa TM 18 1.50e-02 0.331000 6.42e-02
G1/S DNA Damage Checkpoints 63 5.50e-06 0.331000 5.96e-05
RAS processing 21 8.74e-03 0.331000 4.10e-02
Post-chaperonin tubulin folding pathway 17 1.86e-02 0.330000 7.60e-02
Dectin-2 family 14 3.30e-02 -0.329000 1.13e-01
Metalloprotease DUBs 19 1.30e-02 0.329000 5.65e-02
Lysine catabolism 11 5.89e-02 -0.329000 1.70e-01
Somitogenesis 50 5.83e-05 0.329000 4.93e-04
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 1.91e-02 0.328000 7.73e-02
Downstream signaling events of B Cell Receptor (BCR) 78 6.26e-07 0.326000 8.33e-06
Transcriptional regulation of pluripotent stem cells 16 2.40e-02 0.326000 9.06e-02
rRNA modification in the nucleus and cytosol 59 1.57e-05 0.325000 1.49e-04
COPI-mediated anterograde transport 89 1.26e-07 0.324000 2.25e-06
Chaperone Mediated Autophagy 20 1.24e-02 0.323000 5.44e-02
Activation of Matrix Metalloproteinases 21 1.04e-02 0.323000 4.72e-02
Cristae formation 29 2.67e-03 0.322000 1.48e-02
Defective Intrinsic Pathway for Apoptosis 21 1.07e-02 0.322000 4.81e-02
Anchoring fibril formation 11 6.56e-02 0.321000 1.86e-01
MAPK6/MAPK4 signaling 83 5.02e-07 0.319000 6.87e-06
The canonical retinoid cycle in rods (twilight vision) 10 8.08e-02 -0.319000 2.14e-01
Non-integrin membrane-ECM interactions 53 6.00e-05 0.319000 5.04e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 82 6.69e-07 0.318000 8.82e-06
Collagen degradation 50 1.03e-04 0.317000 8.19e-04
Defective B4GALT7 causes EDS, progeroid type 17 2.36e-02 0.317000 8.99e-02
CS/DS degradation 11 6.90e-02 0.317000 1.93e-01
Beta-catenin phosphorylation cascade 17 2.40e-02 0.316000 9.06e-02
SHC-mediated cascade:FGFR2 13 4.98e-02 0.314000 1.54e-01
Complex I biogenesis 51 1.05e-04 0.314000 8.26e-04
Translesion synthesis by REV1 16 2.98e-02 0.314000 1.07e-01
Defective B3GAT3 causes JDSSDHD 17 2.53e-02 0.313000 9.31e-02
The phototransduction cascade 18 2.15e-02 0.313000 8.40e-02
NGF-stimulated transcription 35 1.36e-03 0.313000 7.99e-03
Assembly of the pre-replicative complex 88 4.32e-07 0.312000 5.97e-06
Cleavage of the damaged purine 15 3.66e-02 0.312000 1.23e-01
Depurination 15 3.66e-02 0.312000 1.23e-01
Recognition and association of DNA glycosylase with site containing an affected purine 15 3.66e-02 0.312000 1.23e-01
Gluconeogenesis 27 5.24e-03 0.310000 2.74e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.28e-03 0.310000 1.76e-02
CDK-mediated phosphorylation and removal of Cdc6 70 7.30e-06 0.310000 7.74e-05
Collagen formation 78 2.50e-06 0.308000 2.83e-05
Cytochrome c-mediated apoptotic response 13 5.45e-02 -0.308000 1.62e-01
ERBB2 Activates PTK6 Signaling 11 7.74e-02 -0.307000 2.10e-01
RHO GTPases activate IQGAPs 23 1.07e-02 0.307000 4.81e-02
Synthesis of PE 12 6.62e-02 -0.306000 1.87e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 3.48e-02 0.305000 1.18e-01
COPI-independent Golgi-to-ER retrograde traffic 44 4.79e-04 0.304000 3.26e-03
Phase 4 - resting membrane potential 11 8.17e-02 0.303000 2.16e-01
FRS-mediated FGFR3 signaling 14 4.97e-02 0.303000 1.54e-01
Mitochondrial iron-sulfur cluster biogenesis 13 5.88e-02 0.303000 1.70e-01
Regulation of RAS by GAPs 65 2.50e-05 0.302000 2.28e-04
Formation of Fibrin Clot (Clotting Cascade) 19 2.27e-02 0.302000 8.77e-02
Interleukin-4 and Interleukin-13 signaling 86 1.31e-06 0.302000 1.63e-05
GAB1 signalosome 14 5.07e-02 -0.302000 1.54e-01
Inhibition of DNA recombination at telomere 26 8.03e-03 0.300000 3.85e-02
Downregulation of TGF-beta receptor signaling 26 8.20e-03 0.300000 3.92e-02
Assembly of collagen fibrils and other multimeric structures 52 2.00e-04 0.298000 1.50e-03
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 7.50e-02 0.297000 2.04e-01
MECP2 regulates neuronal receptors and channels 14 5.48e-02 0.297000 1.62e-01
Cargo concentration in the ER 28 6.77e-03 0.296000 3.35e-02
Post-translational protein phosphorylation 74 1.11e-05 0.296000 1.10e-04
Cytosolic tRNA aminoacylation 24 1.23e-02 0.295000 5.39e-02
KEAP1-NFE2L2 pathway 101 2.99e-07 0.295000 4.51e-06
Incretin synthesis, secretion, and inactivation 12 7.83e-02 0.294000 2.11e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 12 7.83e-02 0.294000 2.11e-01
Inactivation, recovery and regulation of the phototransduction cascade 17 3.71e-02 0.292000 1.25e-01
Protein methylation 15 5.03e-02 0.292000 1.54e-01
FCERI mediated NF-kB activation 79 7.51e-06 0.292000 7.86e-05
Pausing and recovery of Tat-mediated HIV elongation 30 5.72e-03 0.292000 2.94e-02
Tat-mediated HIV elongation arrest and recovery 30 5.72e-03 0.292000 2.94e-02
Respiratory electron transport 93 1.31e-06 0.290000 1.63e-05
LGI-ADAM interactions 10 1.12e-01 -0.290000 2.61e-01
FRS-mediated FGFR4 signaling 13 7.03e-02 0.290000 1.96e-01
Antimicrobial peptides 23 1.65e-02 0.289000 6.83e-02
Metabolism of amino acids and derivatives 311 2.42e-18 0.288000 1.22e-16
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 4.00e-02 0.288000 1.31e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 4.00e-02 0.288000 1.31e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 3.60e-05 0.286000 3.14e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 3.60e-05 0.286000 3.14e-04
Synthesis of PIPs at the early endosome membrane 16 4.81e-02 -0.285000 1.51e-01
Transcriptional regulation by RUNX2 112 1.85e-07 0.285000 3.04e-06
Pentose phosphate pathway 13 7.50e-02 0.285000 2.04e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 71 3.28e-05 0.285000 2.89e-04
Switching of origins to a post-replicative state 88 3.84e-06 0.285000 4.23e-05
ECM proteoglycans 58 1.85e-04 0.284000 1.40e-03
TCF dependent signaling in response to WNT 155 1.20e-09 0.283000 3.50e-08
Chaperonin-mediated protein folding 76 2.02e-05 0.283000 1.86e-04
Spry regulation of FGF signaling 16 5.01e-02 0.283000 1.54e-01
Initiation of Nuclear Envelope (NE) Reformation 19 3.32e-02 0.282000 1.14e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 72 3.68e-05 0.281000 3.18e-04
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 2.57e-02 0.281000 9.44e-02
Metal ion SLC transporters 18 3.97e-02 0.280000 1.31e-01
p75NTR signals via NF-kB 16 5.28e-02 0.280000 1.59e-01
ER to Golgi Anterograde Transport 138 1.48e-08 0.279000 3.68e-07
Gastrin-CREB signalling pathway via PKC and MAPK 16 5.35e-02 -0.279000 1.60e-01
Assembly of active LPL and LIPC lipase complexes 11 1.10e-01 0.278000 2.59e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 32 6.51e-03 0.278000 3.23e-02
Signaling by NOTCH4 81 1.57e-05 0.278000 1.49e-04
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 1.29e-01 0.277000 2.94e-01
Translesion synthesis by POLK 17 4.84e-02 0.277000 1.51e-01
Cyclin E associated events during G1/S transition 81 1.72e-05 0.276000 1.61e-04
PCP/CE pathway 86 9.69e-06 0.276000 9.72e-05
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 1.13e-01 0.276000 2.63e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 4.16e-07 0.276000 5.81e-06
Mitochondrial protein import 63 1.55e-04 0.276000 1.20e-03
Metabolism of fat-soluble vitamins 32 7.13e-03 0.275000 3.51e-02
UCH proteinases 85 1.22e-05 0.275000 1.19e-04
Biosynthesis of DHA-derived SPMs 12 1.01e-01 -0.274000 2.45e-01
Hedgehog ‘on’ state 82 1.93e-05 0.273000 1.80e-04
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 11 1.18e-01 0.273000 2.71e-01
TICAM1-dependent activation of IRF3/IRF7 12 1.03e-01 0.272000 2.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 9.22e-02 0.270000 2.32e-01
Metabolism of Angiotensinogen to Angiotensins 13 9.27e-02 0.269000 2.32e-01
ERBB2 Regulates Cell Motility 13 9.33e-02 -0.269000 2.33e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 7.35e-05 0.268000 6.12e-04
Interleukin-1 signaling 107 1.64e-06 0.268000 1.92e-05
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 4.90e-02 0.268000 1.52e-01
Neurodegenerative Diseases 18 4.90e-02 0.268000 1.52e-01
SARS-CoV-1-host interactions 94 7.24e-06 0.268000 7.74e-05
Formation of the beta-catenin:TCF transactivating complex 35 6.16e-03 0.268000 3.10e-02
Inwardly rectifying K+ channels 22 2.99e-02 0.267000 1.07e-01
Mismatch Repair 14 8.38e-02 0.267000 2.19e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 1.10e-01 -0.267000 2.58e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 9.23e-03 0.266000 4.29e-02
Iron uptake and transport 53 8.80e-04 0.264000 5.60e-03
SARS-CoV-2 modulates autophagy 11 1.31e-01 -0.263000 2.97e-01
Inactivation of CSF3 (G-CSF) signaling 24 2.65e-02 0.262000 9.68e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 87 2.59e-05 0.261000 2.34e-04
NPAS4 regulates expression of target genes 18 5.58e-02 0.260000 1.63e-01
Association of TriC/CCT with target proteins during biosynthesis 35 7.75e-03 0.260000 3.77e-02
Response of Mtb to phagocytosis 23 3.09e-02 0.260000 1.09e-01
Elastic fibre formation 40 4.45e-03 0.260000 2.35e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.10e-02 0.260000 1.09e-01
The activation of arylsulfatases 10 1.57e-01 0.258000 3.37e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 2.06e-02 0.257000 8.21e-02
Cyclin A:Cdk2-associated events at S phase entry 83 5.11e-05 0.257000 4.38e-04
HIV elongation arrest and recovery 32 1.18e-02 0.257000 5.22e-02
Pausing and recovery of HIV elongation 32 1.18e-02 0.257000 5.22e-02
Senescence-Associated Secretory Phenotype (SASP) 55 9.77e-04 0.257000 6.09e-03
Autophagy 138 1.91e-07 0.257000 3.10e-06
DNA Replication Pre-Initiation 102 7.52e-06 0.257000 7.86e-05
Chondroitin sulfate/dermatan sulfate metabolism 44 3.22e-03 0.257000 1.73e-02
Lewis blood group biosynthesis 10 1.60e-01 0.257000 3.42e-01
CLEC7A (Dectin-1) signaling 95 1.62e-05 0.256000 1.53e-04
Unwinding of DNA 11 1.42e-01 0.256000 3.15e-01
TNFR2 non-canonical NF-kB pathway 85 5.69e-05 0.253000 4.84e-04
Activation of BAD and translocation to mitochondria 15 9.16e-02 0.252000 2.32e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 14 1.03e-01 0.252000 2.49e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 1.17e-01 0.251000 2.70e-01
TCR signaling 97 2.00e-05 0.251000 1.85e-04
Metabolism of cofactors 18 6.60e-02 0.250000 1.87e-01
Signaling by FGFR4 32 1.51e-02 0.248000 6.44e-02
CLEC7A (Dectin-1) induces NFAT activation 11 1.55e-01 0.248000 3.33e-01
Protein folding 82 1.09e-04 0.247000 8.55e-04
COPI-dependent Golgi-to-ER retrograde traffic 85 8.19e-05 0.247000 6.59e-04
FRS-mediated FGFR2 signaling 15 9.76e-02 0.247000 2.41e-01
Cellular responses to stimuli 696 2.20e-28 0.247000 2.01e-26
CTNNB1 S33 mutants aren’t phosphorylated 15 9.85e-02 0.246000 2.41e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 9.85e-02 0.246000 2.41e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 9.85e-02 0.246000 2.41e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 9.85e-02 0.246000 2.41e-01
Signaling by CTNNB1 phospho-site mutants 15 9.85e-02 0.246000 2.41e-01
Signaling by GSK3beta mutants 15 9.85e-02 0.246000 2.41e-01
Pyrimidine salvage 10 1.77e-01 0.246000 3.70e-01
Hedgehog ‘off’ state 105 1.39e-05 0.246000 1.33e-04
Dopamine Neurotransmitter Release Cycle 19 6.43e-02 0.245000 1.83e-01
Signaling by ALK 27 2.76e-02 0.245000 1.00e-01
Signaling by FGFR3 in disease 16 9.04e-02 0.245000 2.29e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 1.60e-02 -0.242000 6.70e-02
Calnexin/calreticulin cycle 26 3.26e-02 0.242000 1.13e-01
Peroxisomal lipid metabolism 26 3.27e-02 -0.242000 1.13e-01
Translesion synthesis by POLI 17 8.42e-02 0.242000 2.19e-01
Transport to the Golgi and subsequent modification 163 1.07e-07 0.241000 2.00e-06
Cellular responses to stress 687 7.54e-27 0.241000 5.81e-25
Extracellular matrix organization 242 1.26e-10 0.240000 3.91e-09
Signaling by FGFR3 34 1.55e-02 0.240000 6.57e-02
RNA Polymerase III Chain Elongation 18 7.91e-02 0.239000 2.13e-01
Processing of Intronless Pre-mRNAs 20 6.47e-02 -0.239000 1.84e-01
Macroautophagy 124 4.80e-06 0.238000 5.25e-05
Regulation of APC/C activators between G1/S and early anaphase 78 2.88e-04 0.238000 2.08e-03
PTEN Regulation 137 1.62e-06 0.238000 1.92e-05
Biosynthesis of specialized proresolving mediators (SPMs) 14 1.25e-01 -0.237000 2.86e-01
Retinoid metabolism and transport 29 2.76e-02 0.236000 1.00e-01
Formation of paraxial mesoderm 63 1.18e-03 0.236000 7.16e-03
NR1H2 and NR1H3-mediated signaling 40 9.73e-03 -0.236000 4.47e-02
Ras activation upon Ca2+ influx through NMDA receptor 14 1.26e-01 0.236000 2.89e-01
Negative regulation of FGFR1 signaling 25 4.16e-02 0.235000 1.35e-01
Alpha-protein kinase 1 signaling pathway 11 1.77e-01 0.235000 3.70e-01
Scavenging of heme from plasma 10 2.00e-01 0.234000 4.01e-01
Golgi-to-ER retrograde transport 118 1.12e-05 0.234000 1.11e-04
A tetrasaccharide linker sequence is required for GAG synthesis 21 6.36e-02 0.234000 1.81e-01
mTORC1-mediated signalling 24 4.79e-02 0.233000 1.50e-01
Signaling by the B Cell Receptor (BCR) 107 3.14e-05 0.233000 2.79e-04
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 1.46e-01 0.233000 3.21e-01
ER-Phagosome pathway 79 3.53e-04 0.233000 2.48e-03
Gastrulation 85 2.17e-04 0.232000 1.60e-03
Cyclin D associated events in G1 47 6.13e-03 0.231000 3.10e-02
G1 Phase 47 6.13e-03 0.231000 3.10e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.81e-02 0.231000 7.43e-02
NRIF signals cell death from the nucleus 16 1.10e-01 0.231000 2.59e-01
TGF-beta receptor signaling activates SMADs 45 7.43e-03 0.231000 3.62e-02
Infection with Mycobacterium tuberculosis 27 3.86e-02 0.230000 1.28e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 8.33e-02 0.230000 2.18e-01
Dissolution of Fibrin Clot 10 2.09e-01 0.229000 4.11e-01
Paracetamol ADME 19 8.41e-02 -0.229000 2.19e-01
Receptor-type tyrosine-protein phosphatases 12 1.71e-01 0.228000 3.59e-01
Gap junction trafficking 31 2.81e-02 0.228000 1.01e-01
Transcriptional regulation by RUNX1 159 7.21e-07 0.228000 9.42e-06
AKT phosphorylates targets in the nucleus 10 2.14e-01 0.227000 4.14e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 6.02e-02 0.226000 1.73e-01
Signaling by FGFR2 in disease 33 2.47e-02 0.226000 9.22e-02
Downstream signaling of activated FGFR3 19 8.84e-02 0.226000 2.26e-01
Nervous system development 499 7.33e-18 0.226000 3.46e-16
Asparagine N-linked glycosylation 276 1.19e-10 0.226000 3.78e-09
Long-term potentiation 17 1.08e-01 0.225000 2.54e-01
Sema4D induced cell migration and growth-cone collapse 19 8.89e-02 0.225000 2.26e-01
Regulation of localization of FOXO transcription factors 12 1.77e-01 0.225000 3.70e-01
Unfolded Protein Response (UPR) 90 2.28e-04 0.225000 1.67e-03
Uptake and function of anthrax toxins 11 1.97e-01 0.225000 3.96e-01
Regulation of TP53 Expression and Degradation 36 1.97e-02 0.225000 7.92e-02
Cellular response to chemical stress 183 1.71e-07 0.224000 2.84e-06
Axon guidance 479 5.69e-17 0.224000 2.45e-15
FOXO-mediated transcription of cell cycle genes 15 1.34e-01 0.224000 3.01e-01
The citric acid (TCA) cycle and respiratory electron transport 160 1.14e-06 0.223000 1.44e-05
IRAK2 mediated activation of TAK1 complex 10 2.24e-01 0.222000 4.29e-01
RHO GTPases activate PKNs 36 2.14e-02 0.222000 8.40e-02
Apoptotic factor-mediated response 20 8.80e-02 -0.220000 2.26e-01
Formation of WDR5-containing histone-modifying complexes 42 1.39e-02 -0.219000 6.01e-02
Nucleotide salvage 21 8.26e-02 0.219000 2.17e-01
Formation of apoptosome 11 2.10e-01 -0.218000 4.11e-01
Regulation of the apoptosome activity 11 2.10e-01 -0.218000 4.11e-01
MET activates PTK2 signaling 30 3.87e-02 0.218000 1.28e-01
IRE1alpha activates chaperones 49 8.31e-03 0.218000 3.94e-02
Beta-oxidation of very long chain fatty acids 10 2.34e-01 -0.218000 4.39e-01
SARS-CoV-1 Infection 136 1.29e-05 0.217000 1.26e-04
Signaling by FLT3 ITD and TKD mutants 15 1.47e-01 0.216000 3.21e-01
Laminin interactions 27 5.19e-02 0.216000 1.57e-01
Gap junction trafficking and regulation 33 3.20e-02 0.216000 1.11e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 3.48e-02 -0.216000 1.18e-01
COPII-mediated vesicle transport 63 3.11e-03 0.215000 1.68e-02
Mitotic G1 phase and G1/S transition 143 8.98e-06 0.215000 9.13e-05
Regulation of TP53 Degradation 35 2.77e-02 0.215000 1.00e-01
Metabolism of nucleotides 80 9.01e-04 0.215000 5.71e-03
Detoxification of Reactive Oxygen Species 33 3.30e-02 0.215000 1.13e-01
Synthesis of DNA 116 6.73e-05 0.214000 5.63e-04
Transferrin endocytosis and recycling 27 5.45e-02 0.214000 1.62e-01
Base-Excision Repair, AP Site Formation 22 8.26e-02 0.214000 2.17e-01
Acyl chain remodelling of PI 10 2.42e-01 0.214000 4.47e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.70e-02 -0.213000 9.83e-02
NS1 Mediated Effects on Host Pathways 40 1.99e-02 -0.213000 7.98e-02
GRB2 events in ERBB2 signaling 14 1.69e-01 -0.212000 3.56e-01
Downstream signaling of activated FGFR4 18 1.19e-01 0.212000 2.74e-01
IL-6-type cytokine receptor ligand interactions 12 2.03e-01 0.212000 4.06e-01
Cellular hexose transport 13 1.86e-01 -0.212000 3.83e-01
Formation of RNA Pol II elongation complex 56 6.18e-03 0.212000 3.10e-02
RNA Polymerase II Transcription Elongation 56 6.18e-03 0.212000 3.10e-02
RHO GTPases activate PAKs 20 1.02e-01 0.211000 2.46e-01
Trafficking and processing of endosomal TLR 12 2.07e-01 -0.210000 4.11e-01
Cleavage of the damaged pyrimidine 20 1.05e-01 0.209000 2.51e-01
Depyrimidination 20 1.05e-01 0.209000 2.51e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 20 1.05e-01 0.209000 2.51e-01
Nuclear Envelope (NE) Reassembly 67 3.08e-03 0.209000 1.67e-02
Negative regulation of MAPK pathway 41 2.13e-02 0.208000 8.39e-02
Transport of bile salts and organic acids, metal ions and amine compounds 45 1.59e-02 0.208000 6.69e-02
Heme biosynthesis 13 1.95e-01 0.207000 3.95e-01
Signaling by Hedgehog 139 2.51e-05 0.207000 2.28e-04
Interleukin-6 family signaling 18 1.29e-01 0.207000 2.94e-01
XBP1(S) activates chaperone genes 47 1.42e-02 0.207000 6.13e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 4.70e-02 -0.206000 1.48e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 4.70e-02 -0.206000 1.48e-01
RNA Polymerase II Pre-transcription Events 77 1.83e-03 0.206000 1.04e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 11 2.39e-01 0.205000 4.43e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.48e-02 -0.205000 1.43e-01
Peptide hormone metabolism 52 1.06e-02 0.205000 4.78e-02
Repression of WNT target genes 13 2.01e-01 0.205000 4.03e-01
Maturation of spike protein 9694548 37 3.12e-02 0.205000 1.09e-01
APC/C-mediated degradation of cell cycle proteins 83 1.30e-03 0.204000 7.67e-03
Regulation of mitotic cell cycle 83 1.30e-03 0.204000 7.67e-03
Signaling by FGFR2 60 6.28e-03 0.204000 3.14e-02
Insulin receptor recycling 25 7.82e-02 0.204000 2.11e-01
DNA Replication 127 7.57e-05 0.204000 6.19e-04
N-glycan antennae elongation in the medial/trans-Golgi 20 1.16e-01 0.203000 2.68e-01
Nuclear Events (kinase and transcription factor activation) 57 7.99e-03 0.203000 3.85e-02
PI-3K cascade:FGFR1 13 2.05e-01 0.203000 4.08e-01
Regulation of CDH11 function 10 2.68e-01 0.202000 4.73e-01
IRAK1 recruits IKK complex 14 1.92e-01 0.201000 3.91e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 1.92e-01 0.201000 3.91e-01
Sema4D in semaphorin signaling 23 9.47e-02 0.201000 2.36e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.41e-02 0.201000 9.06e-02
HIV Transcription Elongation 42 2.41e-02 0.201000 9.06e-02
Tat-mediated elongation of the HIV-1 transcript 42 2.41e-02 0.201000 9.06e-02
Interleukin-12 family signaling 46 1.87e-02 0.200000 7.62e-02
RUNX3 regulates p14-ARF 10 2.73e-01 0.200000 4.78e-01
Beta-catenin independent WNT signaling 131 8.11e-05 0.200000 6.57e-04
Transport of the SLBP independent Mature mRNA 35 4.13e-02 -0.199000 1.34e-01
G1/S Transition 125 1.26e-04 0.199000 9.79e-04
Signaling by BMP 23 9.95e-02 0.198000 2.42e-01
Sialic acid metabolism 28 7.10e-02 0.197000 1.97e-01
Separation of Sister Chromatids 173 7.93e-06 0.197000 8.23e-05
Translation of Structural Proteins 9683701 29 6.66e-02 0.197000 1.88e-01
Unblocking of NMDA receptors, glutamate binding and activation 15 1.88e-01 0.197000 3.85e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 1.11e-01 0.196000 2.60e-01
Regulation of RUNX1 Expression and Activity 18 1.49e-01 0.196000 3.24e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 2.60e-01 0.196000 4.68e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 33 5.12e-02 0.196000 1.55e-01
FLT3 signaling in disease 27 7.98e-02 0.195000 2.14e-01
Oncogene Induced Senescence 33 5.31e-02 0.195000 1.59e-01
Telomere Extension By Telomerase 21 1.23e-01 0.194000 2.82e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 1.08e-01 0.194000 2.54e-01
Signaling by CSF3 (G-CSF) 29 7.08e-02 0.194000 1.97e-01
Viral Infection Pathways 655 3.61e-17 0.194000 1.60e-15
Metabolism of proteins 1614 1.35e-37 0.193000 9.89e-35
APC truncation mutants have impaired AXIN binding 14 2.10e-01 0.193000 4.11e-01
AXIN missense mutants destabilize the destruction complex 14 2.10e-01 0.193000 4.11e-01
Signaling by AMER1 mutants 14 2.10e-01 0.193000 4.11e-01
Signaling by APC mutants 14 2.10e-01 0.193000 4.11e-01
Signaling by AXIN mutants 14 2.10e-01 0.193000 4.11e-01
Truncations of AMER1 destabilize the destruction complex 14 2.10e-01 0.193000 4.11e-01
Signaling by Leptin 10 2.91e-01 0.193000 4.98e-01
G2/M Checkpoints 124 2.10e-04 0.193000 1.56e-03
Interleukin-1 family signaling 134 1.20e-04 0.193000 9.32e-04
Synthesis of PIPs at the late endosome membrane 11 2.69e-01 -0.192000 4.74e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 9.68e-02 0.192000 2.40e-01
RHOBTB2 GTPase cycle 23 1.12e-01 0.192000 2.61e-01
Mitotic Anaphase 216 1.35e-06 0.191000 1.66e-05
Glycosaminoglycan metabolism 108 6.16e-04 0.191000 4.08e-03
BBSome-mediated cargo-targeting to cilium 21 1.31e-01 0.190000 2.97e-01
DNA methylation 10 2.98e-01 0.190000 5.04e-01
Activation of BH3-only proteins 28 8.41e-02 0.189000 2.19e-01
Assembly of the ORC complex at the origin of replication 14 2.22e-01 0.189000 4.25e-01
Uptake and actions of bacterial toxins 25 1.03e-01 0.188000 2.49e-01
Mitotic Metaphase and Anaphase 217 1.88e-06 0.188000 2.16e-05
Diseases associated with O-glycosylation of proteins 55 1.60e-02 -0.188000 6.69e-02
Downstream signaling of activated FGFR2 20 1.46e-01 0.188000 3.21e-01
Vpr-mediated nuclear import of PICs 34 5.89e-02 -0.187000 1.70e-01
MET promotes cell motility 40 4.05e-02 0.187000 1.32e-01
GABA synthesis, release, reuptake and degradation 12 2.62e-01 0.187000 4.71e-01
ERKs are inactivated 13 2.44e-01 0.187000 4.50e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 2.13e-01 0.186000 4.13e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 2.13e-01 0.186000 4.13e-01
SHC-mediated cascade:FGFR1 13 2.46e-01 0.186000 4.51e-01
Regulation of TP53 Activity through Association with Co-factors 10 3.09e-01 0.186000 5.17e-01
Activation of G protein gated Potassium channels 19 1.62e-01 0.185000 3.43e-01
G protein gated Potassium channels 19 1.62e-01 0.185000 3.43e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 1.62e-01 0.185000 3.43e-01
Transport of the SLBP Dependant Mature mRNA 36 5.58e-02 -0.184000 1.63e-01
ABC-family proteins mediated transport 91 2.41e-03 0.184000 1.34e-02
Signaling by WNT 236 1.14e-06 0.184000 1.44e-05
MET activates RAS signaling 11 2.90e-01 -0.184000 4.98e-01
mRNA 3’-end processing 57 1.65e-02 -0.184000 6.83e-02
ER Quality Control Compartment (ERQC) 21 1.45e-01 0.184000 3.21e-01
Removal of the Flap Intermediate from the C-strand 17 1.90e-01 0.183000 3.89e-01
Fc epsilon receptor (FCERI) signaling 128 3.47e-04 0.183000 2.45e-03
Pyruvate metabolism 27 1.00e-01 0.183000 2.44e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 22 1.39e-01 0.182000 3.11e-01
PERK regulates gene expression 32 7.48e-02 0.182000 2.04e-01
Synthesis of substrates in N-glycan biosythesis 58 1.66e-02 0.182000 6.83e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 42 4.17e-02 0.182000 1.35e-01
Deactivation of the beta-catenin transactivating complex 38 5.32e-02 0.181000 1.59e-01
Developmental Biology 769 1.91e-17 0.181000 8.73e-16
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 6.09e-02 0.181000 1.75e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 3.86e-02 0.180000 1.28e-01
G-protein beta:gamma signalling 27 1.06e-01 -0.180000 2.51e-01
Signaling by PDGFRA extracellular domain mutants 12 2.82e-01 0.179000 4.88e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.82e-01 0.179000 4.88e-01
RORA activates gene expression 18 1.88e-01 -0.179000 3.85e-01
Degradation of the extracellular matrix 105 1.52e-03 0.179000 8.81e-03
Nuclear events stimulated by ALK signaling in cancer 19 1.76e-01 0.179000 3.70e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 2.46e-01 0.179000 4.51e-01
Transcription of the HIV genome 67 1.14e-02 0.179000 5.08e-02
Methylation 12 2.85e-01 0.178000 4.92e-01
Processive synthesis on the C-strand of the telomere 19 1.79e-01 0.178000 3.72e-01
Signaling by FGFR 69 1.06e-02 0.178000 4.78e-02
Norepinephrine Neurotransmitter Release Cycle 14 2.51e-01 0.177000 4.58e-01
Carboxyterminal post-translational modifications of tubulin 30 9.40e-02 0.177000 2.34e-01
Amyloid fiber formation 41 5.07e-02 0.176000 1.54e-01
DNA Double Strand Break Response 43 4.56e-02 0.176000 1.45e-01
Nephrin family interactions 17 2.09e-01 0.176000 4.11e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 9.93e-03 -0.176000 4.53e-02
Caspase activation via Death Receptors in the presence of ligand 15 2.40e-01 -0.175000 4.43e-01
DNA Damage/Telomere Stress Induced Senescence 33 8.27e-02 0.175000 2.17e-01
Formation of the cornified envelope 23 1.48e-01 0.174000 3.21e-01
Keratinization 23 1.48e-01 0.174000 3.21e-01
Receptor Mediated Mitophagy 11 3.17e-01 0.174000 5.26e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 2.60e-01 -0.174000 4.68e-01
Formation of definitive endoderm 10 3.44e-01 0.173000 5.52e-01
SUMOylation of ubiquitinylation proteins 39 6.21e-02 -0.173000 1.78e-01
AKT phosphorylates targets in the cytosol 14 2.63e-01 0.173000 4.71e-01
ADP signalling through P2Y purinoceptor 12 16 2.33e-01 0.172000 4.39e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 5.40e-02 -0.172000 1.61e-01
Translation of Structural Proteins 9694635 57 2.51e-02 0.172000 9.31e-02
PIWI-interacting RNA (piRNA) biogenesis 22 1.64e-01 0.171000 3.47e-01
PI3K events in ERBB2 signaling 14 2.67e-01 -0.171000 4.73e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 3.26e-01 -0.171000 5.36e-01
Signaling by FGFR1 40 6.15e-02 0.171000 1.76e-01
Plasma lipoprotein assembly 11 3.27e-01 -0.171000 5.36e-01
Peptide ligand-binding receptors 77 9.70e-03 0.171000 4.46e-02
Attachment and Entry 9694614 16 2.39e-01 0.170000 4.43e-01
C-type lectin receptors (CLRs) 122 1.19e-03 0.170000 7.17e-03
SUMOylation of immune response proteins 11 3.29e-01 0.170000 5.36e-01
Export of Viral Ribonucleoproteins from Nucleus 33 9.25e-02 -0.169000 2.32e-01
Molecules associated with elastic fibres 33 9.27e-02 0.169000 2.32e-01
Blood group systems biosynthesis 13 2.93e-01 0.168000 5.00e-01
RNA Polymerase III Transcription Termination 23 1.65e-01 0.167000 3.49e-01
Generation of second messenger molecules 16 2.48e-01 -0.167000 4.54e-01
Maturation of nucleoprotein 9683610 11 3.39e-01 -0.166000 5.47e-01
Signaling by TGFB family members 112 2.38e-03 0.166000 1.34e-02
Negative regulation of FLT3 13 3.00e-01 0.166000 5.07e-01
PIP3 activates AKT signaling 240 1.01e-05 0.166000 1.00e-04
Metabolism of RNA 692 1.41e-13 0.166000 5.05e-12
Regulation of PTEN gene transcription 59 2.81e-02 0.165000 1.01e-01
STING mediated induction of host immune responses 15 2.68e-01 -0.165000 4.73e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 30 1.19e-01 0.165000 2.73e-01
S Phase 157 3.91e-04 0.164000 2.71e-03
VLDLR internalisation and degradation 15 2.72e-01 0.164000 4.78e-01
Defects in cobalamin (B12) metabolism 12 3.26e-01 0.164000 5.36e-01
Signaling by Interleukins 376 5.38e-08 0.164000 1.12e-06
DNA Damage Recognition in GG-NER 38 8.11e-02 0.164000 2.14e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 1.58e-02 0.163000 6.67e-02
Integration of energy metabolism 87 8.72e-03 0.163000 4.10e-02
HIV Infection 221 3.14e-05 0.163000 2.79e-04
Transcriptional regulation of granulopoiesis 33 1.06e-01 0.163000 2.51e-01
Hyaluronan metabolism 16 2.60e-01 -0.163000 4.68e-01
RHO GTPases Activate ROCKs 18 2.33e-01 0.162000 4.39e-01
Interleukin-35 Signalling 10 3.75e-01 0.162000 5.79e-01
Meiotic recombination 26 1.54e-01 0.162000 3.31e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 39 8.12e-02 0.161000 2.14e-01
Infectious disease 826 4.60e-15 0.161000 1.68e-13
Initial triggering of complement 20 2.12e-01 -0.161000 4.12e-01
Tie2 Signaling 15 2.80e-01 0.161000 4.88e-01
Chemokine receptors bind chemokines 32 1.15e-01 0.161000 2.68e-01
Formation of the Early Elongation Complex 33 1.12e-01 0.160000 2.61e-01
Formation of the HIV-1 Early Elongation Complex 33 1.12e-01 0.160000 2.61e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 6.98e-02 -0.160000 1.95e-01
EPHA-mediated growth cone collapse 23 1.85e-01 0.160000 3.82e-01
Antigen processing-Cross presentation 92 8.21e-03 0.160000 3.92e-02
Regulation of IFNG signaling 13 3.19e-01 0.160000 5.29e-01
Apoptosis 161 5.02e-04 0.159000 3.39e-03
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 29 1.39e-01 0.159000 3.10e-01
Oxidative Stress Induced Senescence 69 2.28e-02 0.159000 8.78e-02
Rev-mediated nuclear export of HIV RNA 35 1.05e-01 -0.158000 2.51e-01
RAB geranylgeranylation 55 4.25e-02 0.158000 1.37e-01
Signaling by PDGF 53 4.67e-02 0.158000 1.48e-01
Caspase activation via extrinsic apoptotic signalling pathway 23 1.92e-01 -0.157000 3.91e-01
Signaling by NOTCH 173 3.99e-04 0.156000 2.75e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 1.95e-01 0.156000 3.95e-01
Class I peroxisomal membrane protein import 19 2.39e-01 0.156000 4.43e-01
TNFs bind their physiological receptors 17 2.66e-01 -0.156000 4.72e-01
GPER1 signaling 38 9.64e-02 0.156000 2.39e-01
Mitochondrial Fatty Acid Beta-Oxidation 34 1.16e-01 0.156000 2.68e-01
Regulation of TP53 Activity through Acetylation 29 1.47e-01 0.156000 3.21e-01
G2/M Transition 184 2.86e-04 0.155000 2.07e-03
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 3.15e-01 0.155000 5.24e-01
Defective EXT2 causes exostoses 2 14 3.15e-01 0.155000 5.24e-01
SUMOylation of DNA methylation proteins 16 2.83e-01 0.155000 4.89e-01
SUMOylation of SUMOylation proteins 35 1.14e-01 -0.155000 2.64e-01
Transport of Mature Transcript to Cytoplasm 81 1.63e-02 -0.154000 6.78e-02
Muscle contraction 138 1.78e-03 0.154000 1.02e-02
Interleukin-12 signaling 40 9.18e-02 0.154000 2.32e-01
HIV Transcription Initiation 45 7.40e-02 0.154000 2.03e-01
RNA Polymerase II HIV Promoter Escape 45 7.40e-02 0.154000 2.03e-01
RNA Polymerase II Promoter Escape 45 7.40e-02 0.154000 2.03e-01
RNA Polymerase II Transcription Initiation 45 7.40e-02 0.154000 2.03e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 7.40e-02 0.154000 2.03e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 7.40e-02 0.154000 2.03e-01
Late SARS-CoV-2 Infection Events 66 3.07e-02 0.154000 1.09e-01
Amine ligand-binding receptors 10 4.00e-01 0.154000 6.01e-01
CTLA4 inhibitory signaling 18 2.60e-01 0.153000 4.68e-01
Protein localization 154 1.05e-03 0.153000 6.41e-03
Metabolism of carbohydrates 253 3.05e-05 0.153000 2.74e-04
Signaling by ALK fusions and activated point mutants 55 5.07e-02 0.152000 1.54e-01
Signaling by ALK in cancer 55 5.07e-02 0.152000 1.54e-01
Acyl chain remodelling of PE 18 2.63e-01 -0.152000 4.71e-01
Ion homeostasis 40 9.56e-02 0.152000 2.38e-01
Mitotic G2-G2/M phases 186 3.49e-04 0.152000 2.46e-03
Programmed Cell Death 188 3.25e-04 0.152000 2.31e-03
Other interleukin signaling 20 2.39e-01 -0.152000 4.43e-01
Processing of SMDT1 15 3.09e-01 0.152000 5.17e-01
RHO GTPases activate CIT 18 2.65e-01 0.152000 4.71e-01
Ub-specific processing proteases 156 1.09e-03 0.152000 6.63e-03
Disorders of transmembrane transporters 137 2.24e-03 0.151000 1.27e-02
rRNA processing in the mitochondrion 10 4.08e-01 0.151000 6.09e-01
Physiological factors 10 4.09e-01 0.151000 6.10e-01
Visual phototransduction 56 5.13e-02 0.151000 1.55e-01
RHOG GTPase cycle 70 3.08e-02 0.149000 1.09e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 3.71e-01 -0.149000 5.78e-01
Prostacyclin signalling through prostacyclin receptor 14 3.35e-01 0.149000 5.42e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 4.15e-01 0.149000 6.17e-01
Cardiogenesis 19 2.63e-01 0.148000 4.71e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 31 1.53e-01 0.148000 3.30e-01
Platelet degranulation 105 9.14e-03 0.147000 4.26e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 5.88e-02 0.147000 1.70e-01
mRNA Splicing - Minor Pathway 50 7.16e-02 0.147000 1.98e-01
Branched-chain amino acid catabolism 21 2.46e-01 -0.146000 4.51e-01
Activation of the AP-1 family of transcription factors 10 4.24e-01 0.146000 6.23e-01
Neddylation 223 1.76e-04 0.146000 1.35e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 2.36e-01 0.146000 4.42e-01
p75NTR recruits signalling complexes 13 3.63e-01 0.146000 5.72e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.32e-01 0.145000 2.97e-01
Classical antibody-mediated complement activation 10 4.27e-01 -0.145000 6.26e-01
Metabolism of folate and pterines 16 3.15e-01 0.145000 5.24e-01
VEGFR2 mediated cell proliferation 19 2.75e-01 0.145000 4.80e-01
Resolution of D-Loop Structures 33 1.50e-01 -0.145000 3.25e-01
IRS-related events triggered by IGF1R 37 1.30e-01 0.144000 2.95e-01
Acetylcholine Neurotransmitter Release Cycle 12 3.88e-01 0.144000 5.90e-01
Serotonin Neurotransmitter Release Cycle 14 3.53e-01 0.143000 5.62e-01
Bacterial Infection Pathways 65 4.59e-02 0.143000 1.45e-01
IGF1R signaling cascade 38 1.27e-01 0.143000 2.90e-01
Host Interactions of HIV factors 125 5.97e-03 0.143000 3.06e-02
Metabolism of porphyrins 21 2.58e-01 0.142000 4.67e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 2.19e-01 0.142000 4.22e-01
Glycogen breakdown (glycogenolysis) 13 3.75e-01 0.142000 5.79e-01
Fatty acyl-CoA biosynthesis 29 1.86e-01 0.142000 3.83e-01
Signaling by TGF-beta Receptor Complex 90 2.04e-02 0.142000 8.13e-02
Purine salvage 12 3.96e-01 0.141000 5.98e-01
Early SARS-CoV-2 Infection Events 33 1.62e-01 0.141000 3.43e-01
Signaling by WNT in cancer 28 1.99e-01 0.140000 3.99e-01
LDL clearance 18 3.04e-01 -0.140000 5.11e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.46e-01 0.140000 3.21e-01
Metabolism 1716 1.93e-21 0.140000 1.09e-19
Interactions of Vpr with host cellular proteins 37 1.41e-01 -0.140000 3.14e-01
Response to elevated platelet cytosolic Ca2+ 109 1.18e-02 0.140000 5.22e-02
Metabolism of steroid hormones 20 2.81e-01 -0.139000 4.88e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 4.03e-01 -0.139000 6.04e-01
Growth hormone receptor signaling 20 2.81e-01 0.139000 4.88e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 3.85e-01 0.139000 5.86e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 2.20e-01 0.139000 4.22e-01
CD28 dependent Vav1 pathway 10 4.46e-01 -0.139000 6.45e-01
Leading Strand Synthesis 14 3.68e-01 -0.139000 5.77e-01
Polymerase switching 14 3.68e-01 -0.139000 5.77e-01
Intracellular signaling by second messengers 276 7.46e-05 0.139000 6.17e-04
Cellular Senescence 131 6.15e-03 0.139000 3.10e-02
Signaling by MET 75 3.82e-02 0.138000 1.27e-01
Metabolic disorders of biological oxidation enzymes 23 2.53e-01 0.138000 4.60e-01
Nucleotide catabolism 23 2.53e-01 0.138000 4.60e-01
G alpha (z) signalling events 38 1.43e-01 0.137000 3.17e-01
DAP12 signaling 25 2.35e-01 -0.137000 4.41e-01
Estrogen-dependent gene expression 90 2.48e-02 0.137000 9.22e-02
Signaling by ERBB2 TMD/JMD mutants 20 2.93e-01 -0.136000 4.99e-01
FRS-mediated FGFR1 signaling 15 3.62e-01 0.136000 5.72e-01
Intraflagellar transport 48 1.04e-01 0.136000 2.49e-01
Sphingolipid de novo biosynthesis 37 1.53e-01 0.136000 3.31e-01
FGFR2 alternative splicing 24 2.50e-01 0.136000 4.57e-01
mRNA Capping 29 2.06e-01 0.136000 4.10e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 2.15e-01 0.136000 4.16e-01
Acyl chain remodelling of PC 19 3.09e-01 -0.135000 5.17e-01
Cytosolic iron-sulfur cluster assembly 13 4.00e-01 -0.135000 6.01e-01
Pre-NOTCH Processing in Golgi 18 3.23e-01 0.134000 5.34e-01
Class B/2 (Secretin family receptors) 49 1.04e-01 0.134000 2.49e-01
Regulation of NPAS4 gene expression 12 4.21e-01 -0.134000 6.21e-01
Signaling by NTRK1 (TRKA) 108 1.62e-02 0.134000 6.76e-02
Miscellaneous transport and binding events 21 2.88e-01 0.134000 4.96e-01
Deposition of new CENPA-containing nucleosomes at the centromere 30 2.05e-01 0.134000 4.08e-01
Nucleosome assembly 30 2.05e-01 0.134000 4.08e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 3.54e-01 -0.134000 5.63e-01
Interleukin-15 signaling 13 4.04e-01 0.134000 6.04e-01
HCMV Infection 98 2.25e-02 0.133000 8.74e-02
Constitutive Signaling by EGFRvIII 15 3.71e-01 -0.133000 5.78e-01
Signaling by EGFRvIII in Cancer 15 3.71e-01 -0.133000 5.78e-01
Termination of O-glycan biosynthesis 14 3.88e-01 0.133000 5.90e-01
activated TAK1 mediates p38 MAPK activation 23 2.71e-01 0.133000 4.77e-01
Signaling by FGFR in disease 52 9.85e-02 0.132000 2.41e-01
FCGR activation 15 3.75e-01 -0.132000 5.79e-01
MAPK family signaling cascades 265 2.12e-04 0.132000 1.57e-03
PI Metabolism 78 4.36e-02 -0.132000 1.40e-01
TP53 Regulates Metabolic Genes 80 4.15e-02 0.132000 1.35e-01
RAF/MAP kinase cascade 225 6.65e-04 0.132000 4.37e-03
Signaling by Insulin receptor 63 7.13e-02 0.131000 1.98e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 2.39e-01 0.131000 4.43e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 2.39e-01 0.131000 4.43e-01
HS-GAG biosynthesis 24 2.67e-01 0.131000 4.73e-01
Late Phase of HIV Life Cycle 132 9.68e-03 0.131000 4.46e-02
tRNA Aminoacylation 42 1.44e-01 0.130000 3.19e-01
Glutamate and glutamine metabolism 11 4.55e-01 0.130000 6.52e-01
Glutathione synthesis and recycling 10 4.76e-01 -0.130000 6.70e-01
Potential therapeutics for SARS 92 3.11e-02 0.130000 1.09e-01
Regulation of IFNA/IFNB signaling 12 4.35e-01 0.130000 6.33e-01
Creation of C4 and C2 activators 13 4.17e-01 -0.130000 6.18e-01
Glucagon-type ligand receptors 17 3.55e-01 0.130000 5.63e-01
Cell surface interactions at the vascular wall 106 2.13e-02 0.130000 8.39e-02
Adenylate cyclase activating pathway 10 4.79e-01 -0.129000 6.72e-01
PKMTs methylate histone lysines 42 1.47e-01 -0.129000 3.21e-01
Regulation of insulin secretion 60 8.36e-02 0.129000 2.18e-01
SUMOylation of DNA replication proteins 45 1.34e-01 -0.129000 3.02e-01
PLC beta mediated events 45 1.34e-01 -0.129000 3.02e-01
Diseases of mitotic cell cycle 38 1.69e-01 0.129000 3.56e-01
MAPK1/MAPK3 signaling 230 7.93e-04 0.129000 5.09e-03
Metabolism of vitamins and cofactors 156 5.66e-03 0.129000 2.94e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 185 2.66e-03 0.128000 1.48e-02
Nuclear import of Rev protein 34 1.96e-01 -0.128000 3.96e-01
Signaling by Erythropoietin 24 2.78e-01 -0.128000 4.85e-01
O-linked glycosylation of mucins 41 1.56e-01 0.128000 3.35e-01
Disease 1460 7.99e-16 0.127000 3.25e-14
Mitotic Telophase/Cytokinesis 13 4.27e-01 -0.127000 6.26e-01
Toll Like Receptor 3 (TLR3) Cascade 102 2.64e-02 0.127000 9.68e-02
Transport of vitamins, nucleosides, and related molecules 29 2.36e-01 0.127000 4.41e-01
Adherens junctions interactions 43 1.50e-01 0.127000 3.24e-01
Aquaporin-mediated transport 36 1.88e-01 0.127000 3.85e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 4.87e-01 0.127000 6.79e-01
Ovarian tumor domain proteases 35 1.95e-01 0.127000 3.95e-01
Deubiquitination 227 1.03e-03 0.127000 6.36e-03
Activation of gene expression by SREBF (SREBP) 42 1.60e-01 0.125000 3.42e-01
Post-translational protein modification 1177 8.07e-13 0.125000 2.81e-11
Platelet sensitization by LDL 17 3.74e-01 0.125000 5.79e-01
FGFR1 mutant receptor activation 25 2.82e-01 0.124000 4.88e-01
Phase 2 - plateau phase 10 4.96e-01 0.124000 6.88e-01
The NLRP3 inflammasome 16 3.90e-01 0.124000 5.92e-01
Cardiac conduction 88 4.48e-02 0.124000 1.43e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 2.27e-01 -0.123000 4.31e-01
P2Y receptors 11 4.80e-01 -0.123000 6.73e-01
Activation of GABAB receptors 32 2.28e-01 0.123000 4.33e-01
GABA B receptor activation 32 2.28e-01 0.123000 4.33e-01
Interleukin-10 signaling 31 2.37e-01 0.123000 4.43e-01
Telomere Maintenance 69 7.93e-02 0.122000 2.13e-01
Ca-dependent events 33 2.25e-01 -0.122000 4.30e-01
Phase I - Functionalization of compounds 66 8.76e-02 0.122000 2.26e-01
Azathioprine ADME 18 3.72e-01 0.122000 5.78e-01
Signaling by ERBB2 in Cancer 24 3.03e-01 -0.121000 5.11e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 5.06e-01 0.121000 6.95e-01
TRAF6 mediated NF-kB activation 22 3.26e-01 -0.121000 5.36e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 4.33e-01 -0.121000 6.30e-01
Downstream signaling of activated FGFR1 21 3.38e-01 0.121000 5.45e-01
MAP kinase activation 63 9.93e-02 0.120000 2.42e-01
Olfactory Signaling Pathway 27 2.81e-01 0.120000 4.88e-01
Signaling by KIT in disease 19 3.66e-01 0.120000 5.76e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 3.66e-01 0.120000 5.76e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 3.93e-01 0.120000 5.95e-01
DAP12 interactions 33 2.35e-01 -0.119000 4.41e-01
Fanconi Anemia Pathway 35 2.22e-01 -0.119000 4.25e-01
Activation of NMDA receptors and postsynaptic events 74 7.66e-02 0.119000 2.08e-01
MHC class II antigen presentation 96 4.48e-02 0.119000 1.43e-01
Cytosolic sulfonation of small molecules 19 3.71e-01 0.119000 5.78e-01
Cell Cycle Checkpoints 238 1.69e-03 0.118000 9.70e-03
Synthesis of glycosylphosphatidylinositol (GPI) 18 3.85e-01 -0.118000 5.86e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 4.61e-01 0.118000 6.60e-01
ROS and RNS production in phagocytes 30 2.64e-01 0.118000 4.71e-01
PI3K Cascade 30 2.64e-01 0.118000 4.71e-01
ALK mutants bind TKIs 12 4.80e-01 0.118000 6.73e-01
Diseases of signal transduction by growth factor receptors and second messengers 387 7.52e-05 0.118000 6.18e-04
Triglyceride catabolism 16 4.16e-01 0.117000 6.17e-01
Activation of kainate receptors upon glutamate binding 23 3.30e-01 0.117000 5.36e-01
Erythropoietin activates RAS 13 4.64e-01 -0.117000 6.61e-01
TAK1-dependent IKK and NF-kappa-B activation 42 1.90e-01 0.117000 3.89e-01
O-glycosylation of TSR domain-containing proteins 35 2.32e-01 -0.117000 4.39e-01
Interactions of Rev with host cellular proteins 37 2.20e-01 -0.117000 4.22e-01
Meiotic synapsis 31 2.62e-01 0.116000 4.71e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.66e-01 0.115000 4.73e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.29e-01 0.115000 5.36e-01
IKK complex recruitment mediated by RIP1 23 3.41e-01 0.115000 5.49e-01
Vitamin B5 (pantothenate) metabolism 16 4.28e-01 -0.114000 6.27e-01
IRF3-mediated induction of type I IFN 12 4.93e-01 -0.114000 6.85e-01
HIV Life Cycle 145 1.78e-02 0.114000 7.31e-02
RAF activation 33 2.57e-01 0.114000 4.66e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 1.78e-01 0.114000 3.70e-01
CD209 (DC-SIGN) signaling 20 3.79e-01 0.114000 5.81e-01
APC-Cdc20 mediated degradation of Nek2A 25 3.27e-01 0.113000 5.36e-01
Synaptic adhesion-like molecules 18 4.07e-01 0.113000 6.08e-01
Tryptophan catabolism 10 5.39e-01 -0.112000 7.24e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.31e-01 0.112000 2.97e-01
ESR-mediated signaling 152 1.88e-02 0.110000 7.67e-02
Signaling by NOTCH2 30 2.96e-01 0.110000 5.01e-01
MyD88-independent TLR4 cascade 106 5.01e-02 0.110000 1.54e-01
TRIF(TICAM1)-mediated TLR4 signaling 106 5.01e-02 0.110000 1.54e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 50 1.78e-01 0.110000 3.71e-01
Diseases of glycosylation 127 3.24e-02 0.110000 1.13e-01
CaM pathway 31 2.89e-01 -0.110000 4.96e-01
Calmodulin induced events 31 2.89e-01 -0.110000 4.96e-01
Interferon gamma signaling 73 1.04e-01 -0.110000 2.50e-01
Hemostasis 475 4.75e-05 0.109000 4.09e-04
ATF4 activates genes in response to endoplasmic reticulum stress 27 3.26e-01 0.109000 5.36e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.45e-01 0.109000 5.52e-01
Cytosolic sensors of pathogen-associated DNA 61 1.41e-01 0.109000 3.14e-01
RAF-independent MAPK1/3 activation 20 3.99e-01 0.109000 6.01e-01
SHC1 events in ERBB2 signaling 20 4.00e-01 -0.109000 6.01e-01
Base Excision Repair 50 1.84e-01 0.109000 3.82e-01
Platelet calcium homeostasis 21 3.90e-01 0.108000 5.92e-01
Signaling by ERBB2 KD Mutants 23 3.70e-01 -0.108000 5.78e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 6.14e-02 -0.108000 1.76e-01
L1CAM interactions 97 6.73e-02 0.108000 1.89e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 2.58e-01 0.107000 4.67e-01
Synthesis of very long-chain fatty acyl-CoAs 17 4.46e-01 0.107000 6.45e-01
Interleukin receptor SHC signaling 20 4.09e-01 -0.107000 6.10e-01
Signaling by Activin 13 5.06e-01 0.106000 6.95e-01
Elevation of cytosolic Ca2+ levels 12 5.24e-01 0.106000 7.09e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 5.42e-01 -0.106000 7.26e-01
Cytoprotection by HMOX1 58 1.62e-01 0.106000 3.43e-01
Defective pyroptosis 19 4.23e-01 -0.106000 6.22e-01
Regulation of MECP2 expression and activity 27 3.41e-01 -0.106000 5.49e-01
Neurotransmitter release cycle 36 2.72e-01 0.106000 4.78e-01
RNA Polymerase II Transcription Termination 66 1.38e-01 -0.106000 3.09e-01
Potassium Channels 52 1.90e-01 0.105000 3.89e-01
Nuclear signaling by ERBB4 27 3.45e-01 -0.105000 5.52e-01
Activation of SMO 16 4.67e-01 0.105000 6.62e-01
Cohesin Loading onto Chromatin 10 5.66e-01 -0.105000 7.43e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 4.68e-01 -0.105000 6.62e-01
Recycling pathway of L1 40 2.53e-01 0.105000 4.60e-01
Degradation of cysteine and homocysteine 12 5.31e-01 0.104000 7.16e-01
Nucleotide biosynthesis 12 5.31e-01 0.104000 7.16e-01
Chromosome Maintenance 92 8.51e-02 0.104000 2.20e-01
Signaling by FLT3 fusion proteins 19 4.33e-01 0.104000 6.30e-01
RIPK1-mediated regulated necrosis 30 3.26e-01 0.104000 5.36e-01
Regulation of necroptotic cell death 30 3.26e-01 0.104000 5.36e-01
Biological oxidations 138 3.59e-02 0.104000 1.22e-01
Defective B3GALTL causes PpS 34 2.99e-01 -0.103000 5.06e-01
Recognition of DNA damage by PCNA-containing replication complex 29 3.38e-01 0.103000 5.45e-01
Transcriptional Regulation by NPAS4 30 3.30e-01 0.103000 5.36e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 1.81e-01 0.103000 3.75e-01
Platelet activation, signaling and aggregation 217 9.44e-03 0.102000 4.37e-02
Notch-HLH transcription pathway 28 3.49e-01 -0.102000 5.56e-01
Phase II - Conjugation of compounds 68 1.45e-01 0.102000 3.21e-01
MyD88 cascade initiated on plasma membrane 93 8.89e-02 0.102000 2.26e-01
Toll Like Receptor 10 (TLR10) Cascade 93 8.89e-02 0.102000 2.26e-01
Toll Like Receptor 5 (TLR5) Cascade 93 8.89e-02 0.102000 2.26e-01
TNFR1-induced proapoptotic signaling 25 3.77e-01 -0.102000 5.80e-01
RMTs methylate histone arginines 33 3.10e-01 0.102000 5.19e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 5.60e-01 0.102000 7.42e-01
Ephrin signaling 17 4.69e-01 -0.101000 6.62e-01
Signaling by ERBB2 ECD mutants 16 4.83e-01 -0.101000 6.76e-01
Interleukin-17 signaling 67 1.53e-01 0.101000 3.30e-01
Nuclear Envelope Breakdown 53 2.03e-01 -0.101000 4.06e-01
Meiosis 50 2.17e-01 0.101000 4.18e-01
Signaling by NTRKs 123 5.55e-02 0.100000 1.63e-01
RUNX2 regulates bone development 27 3.69e-01 0.099900 5.78e-01
IRS-mediated signalling 34 3.14e-01 0.099800 5.23e-01
RND1 GTPase cycle 37 2.94e-01 0.099800 5.00e-01
Epigenetic regulation of gene expression 132 4.84e-02 -0.099600 1.51e-01
Signaling by high-kinase activity BRAF mutants 30 3.46e-01 -0.099400 5.53e-01
SARS-CoV Infections 375 1.03e-03 0.099000 6.36e-03
RUNX2 regulates osteoblast differentiation 21 4.33e-01 0.098900 6.30e-01
Diseases of metabolism 206 1.48e-02 0.098700 6.35e-02
SHC1 events in ERBB4 signaling 12 5.55e-01 -0.098500 7.38e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 3.21e-01 0.098400 5.31e-01
Lysosome Vesicle Biogenesis 33 3.28e-01 -0.098400 5.36e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 2.25e-01 0.098200 4.30e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 5.74e-01 -0.098000 7.46e-01
alpha-linolenic acid (ALA) metabolism 11 5.74e-01 -0.098000 7.46e-01
M Phase 342 1.89e-03 0.098000 1.07e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 107 8.03e-02 0.097900 2.14e-01
Toll Like Receptor 2 (TLR2) Cascade 107 8.03e-02 0.097900 2.14e-01
Toll Like Receptor TLR1:TLR2 Cascade 107 8.03e-02 0.097900 2.14e-01
Toll Like Receptor TLR6:TLR2 Cascade 107 8.03e-02 0.097900 2.14e-01
Signaling by Non-Receptor Tyrosine Kinases 51 2.27e-01 0.097900 4.31e-01
Signaling by PTK6 51 2.27e-01 0.097900 4.31e-01
Nucleotide-like (purinergic) receptors 15 5.12e-01 -0.097900 7.00e-01
Formation of TC-NER Pre-Incision Complex 53 2.18e-01 0.097800 4.21e-01
EML4 and NUDC in mitotic spindle formation 101 9.13e-02 0.097300 2.31e-01
PECAM1 interactions 11 5.78e-01 -0.097000 7.47e-01
Downstream signal transduction 28 3.80e-01 0.095800 5.81e-01
RHO GTPases Activate Formins 123 6.82e-02 0.095300 1.92e-01
RA biosynthesis pathway 16 5.09e-01 -0.095300 6.98e-01
Defects in vitamin and cofactor metabolism 20 4.62e-01 0.095100 6.60e-01
Insulin receptor signalling cascade 39 3.04e-01 0.095100 5.11e-01
Signaling by PDGFR in disease 20 4.62e-01 0.095100 6.60e-01
Kinesins 46 2.65e-01 0.095100 4.71e-01
Neurotransmitter receptors and postsynaptic signal transmission 138 5.44e-02 0.095000 1.62e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 4.74e-01 0.094900 6.68e-01
Resolution of Sister Chromatid Cohesion 110 8.77e-02 0.094300 2.26e-01
cGMP effects 13 5.58e-01 0.093900 7.40e-01
Signaling by RAF1 mutants 34 3.45e-01 -0.093600 5.52e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.96e-01 0.093500 3.96e-01
Transmission across Chemical Synapses 182 3.01e-02 0.093300 1.07e-01
DCC mediated attractive signaling 13 5.62e-01 0.093000 7.42e-01
Stimuli-sensing channels 71 1.77e-01 -0.092800 3.70e-01
G alpha (12/13) signalling events 70 1.82e-01 -0.092200 3.78e-01
Platelet Aggregation (Plug Formation) 29 3.91e-01 0.092100 5.92e-01
RHOH GTPase cycle 31 3.75e-01 0.092000 5.79e-01
Neutrophil degranulation 408 1.48e-03 0.092000 8.63e-03
Antigen processing: Ubiquitination & Proteasome degradation 283 7.91e-03 0.091900 3.82e-02
Rap1 signalling 13 5.66e-01 -0.091800 7.43e-01
Circadian Clock 66 1.98e-01 0.091700 3.98e-01
Myogenesis 20 4.78e-01 0.091600 6.72e-01
Cytokine Signaling in Immune system 577 1.90e-04 0.091300 1.43e-03
WNT5A-dependent internalization of FZD4 14 5.57e-01 0.090600 7.40e-01
Cell-extracellular matrix interactions 18 5.07e-01 0.090400 6.95e-01
Basigin interactions 21 4.75e-01 0.090100 6.69e-01
Extra-nuclear estrogen signaling 65 2.09e-01 0.090100 4.11e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 5.21e-01 -0.090000 7.09e-01
p38MAPK events 13 5.75e-01 -0.089800 7.47e-01
Ion transport by P-type ATPases 40 3.28e-01 0.089300 5.36e-01
Phase 0 - rapid depolarisation 22 4.69e-01 0.089300 6.62e-01
Platelet homeostasis 68 2.03e-01 0.089300 4.06e-01
RIP-mediated NFkB activation via ZBP1 16 5.38e-01 0.089000 7.23e-01
GPCR ligand binding 194 3.35e-02 0.088700 1.14e-01
Cellular response to heat stress 95 1.36e-01 0.088600 3.05e-01
CASP8 activity is inhibited 10 6.28e-01 -0.088600 7.89e-01
Dimerization of procaspase-8 10 6.28e-01 -0.088600 7.89e-01
Regulation by c-FLIP 10 6.28e-01 -0.088600 7.89e-01
NRAGE signals death through JNK 56 2.52e-01 -0.088500 4.59e-01
Cell Cycle, Mitotic 479 9.50e-04 0.088500 5.95e-03
Nucleotide Excision Repair 110 1.09e-01 0.088400 2.58e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 5.28e-01 -0.088300 7.14e-01
NCAM1 interactions 30 4.04e-01 0.088100 6.04e-01
Diseases of carbohydrate metabolism 28 4.23e-01 0.087500 6.22e-01
IRAK4 deficiency (TLR2/4) 15 5.60e-01 -0.086900 7.42e-01
G1/S-Specific Transcription 25 4.53e-01 -0.086700 6.52e-01
Regulation of TLR by endogenous ligand 15 5.61e-01 -0.086700 7.42e-01
SARS-CoV-2 Infection 265 1.54e-02 0.086600 6.56e-02
Telomere C-strand synthesis initiation 13 5.91e-01 0.086200 7.55e-01
Formation of Incision Complex in GG-NER 43 3.30e-01 0.085900 5.36e-01
Post NMDA receptor activation events 63 2.39e-01 0.085800 4.43e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 5.79e-01 0.085700 7.48e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 5.93e-01 0.085500 7.57e-01
Downregulation of ERBB2 signaling 27 4.42e-01 0.085500 6.42e-01
PI3K/AKT Signaling in Cancer 81 1.85e-01 0.085200 3.83e-01
Signal amplification 27 4.45e-01 0.085000 6.44e-01
Signal Transduction 2005 6.41e-10 0.085000 1.96e-08
Regulated proteolysis of p75NTR 11 6.26e-01 0.085000 7.89e-01
RHO GTPase Effectors 242 2.36e-02 0.084700 8.99e-02
RNA Polymerase III Transcription Initiation 36 3.80e-01 0.084600 5.81e-01
Class A/1 (Rhodopsin-like receptors) 141 8.50e-02 0.084100 2.20e-01
MET activates RAP1 and RAC1 11 6.29e-01 -0.084000 7.90e-01
Sensory perception of taste 16 5.62e-01 -0.083900 7.42e-01
RHO GTPases Activate WASPs and WAVEs 35 3.91e-01 0.083800 5.92e-01
Sensory Perception 146 8.10e-02 0.083700 2.14e-01
Toll Like Receptor 4 (TLR4) Cascade 135 9.34e-02 0.083700 2.33e-01
SIRT1 negatively regulates rRNA expression 14 5.89e-01 -0.083500 7.54e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.00e-01 0.083400 6.01e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 5.77e-01 0.083300 7.47e-01
Transcriptional Regulation by TP53 339 8.59e-03 0.083300 4.06e-02
Inflammasomes 20 5.21e-01 0.082900 7.09e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 5.66e-01 -0.082900 7.43e-01
Amino acids regulate mTORC1 49 3.16e-01 0.082800 5.25e-01
Tight junction interactions 16 5.67e-01 -0.082700 7.43e-01
Signaling by FGFR4 in disease 10 6.52e-01 -0.082400 8.05e-01
Early Phase of HIV Life Cycle 14 5.97e-01 -0.081700 7.60e-01
Pre-NOTCH Expression and Processing 55 2.95e-01 0.081600 5.01e-01
Signaling by Receptor Tyrosine Kinases 462 2.79e-03 0.081500 1.53e-02
Regulation of TP53 Activity 148 8.93e-02 0.081000 2.27e-01
Interleukin-2 family signaling 33 4.21e-01 -0.080900 6.21e-01
Signaling by Hippo 19 5.42e-01 0.080900 7.26e-01
Transcriptional regulation of white adipocyte differentiation 81 2.09e-01 0.080800 4.11e-01
Processive synthesis on the lagging strand 15 5.88e-01 -0.080700 7.54e-01
GABA receptor activation 40 3.77e-01 0.080700 5.80e-01
Insulin processing 21 5.24e-01 0.080400 7.09e-01
MTOR signalling 40 3.80e-01 0.080200 5.81e-01
Regulation of Complement cascade 34 4.21e-01 0.079800 6.21e-01
FCGR3A-mediated IL10 synthesis 40 3.84e-01 -0.079500 5.86e-01
TBC/RABGAPs 44 3.63e-01 -0.079300 5.72e-01
Cell-Cell communication 113 1.47e-01 0.079000 3.21e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.73e-01 -0.078900 7.46e-01
Lagging Strand Synthesis 20 5.42e-01 -0.078900 7.26e-01
Amino acid transport across the plasma membrane 20 5.43e-01 0.078600 7.26e-01
Signaling by NOTCH3 45 3.62e-01 0.078600 5.72e-01
Factors involved in megakaryocyte development and platelet production 116 1.45e-01 0.078500 3.20e-01
Protein-protein interactions at synapses 62 2.87e-01 0.078200 4.96e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.16e-01 0.078100 4.18e-01
Cell junction organization 86 2.13e-01 0.077700 4.14e-01
Glucagon signaling in metabolic regulation 26 4.94e-01 0.077500 6.86e-01
Maturation of nucleoprotein 9694631 15 6.03e-01 -0.077500 7.66e-01
Cell Cycle 589 1.38e-03 0.077500 8.11e-03
Transport of small molecules 521 2.88e-03 0.076600 1.57e-02
Polo-like kinase mediated events 14 6.21e-01 -0.076400 7.85e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 2.45e-01 0.076200 4.51e-01
Condensation of Prometaphase Chromosomes 11 6.64e-01 -0.075600 8.16e-01
Ca2+ pathway 53 3.45e-01 0.075000 5.52e-01
SARS-CoV-2-host interactions 176 8.78e-02 0.074700 2.26e-01
VxPx cargo-targeting to cilium 17 5.94e-01 -0.074700 7.58e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 6.55e-01 0.074500 8.07e-01
Activation of RAC1 11 6.70e-01 0.074200 8.16e-01
Bile acid and bile salt metabolism 28 4.98e-01 -0.074100 6.89e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 5.00e-01 0.073700 6.90e-01
Activation of the pre-replicative complex 29 4.93e-01 0.073600 6.85e-01
Innate Immune System 844 3.23e-04 0.073400 2.31e-03
G-protein mediated events 49 3.77e-01 -0.072900 5.80e-01
Role of LAT2/NTAL/LAB on calcium mobilization 18 5.92e-01 -0.072900 7.57e-01
Sphingolipid metabolism 73 2.82e-01 0.072900 4.88e-01
Interleukin-37 signaling 20 5.73e-01 -0.072800 7.46e-01
HS-GAG degradation 22 5.55e-01 -0.072800 7.38e-01
Mitochondrial calcium ion transport 21 5.65e-01 0.072600 7.43e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 5.84e-01 0.072500 7.51e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 5.84e-01 0.072500 7.51e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 99 2.16e-01 0.072000 4.18e-01
Sensory processing of sound by inner hair cells of the cochlea 47 3.94e-01 0.071900 5.95e-01
Gap junction degradation 12 6.66e-01 -0.071900 8.16e-01
EPHB-mediated forward signaling 38 4.47e-01 -0.071400 6.45e-01
Phospholipid metabolism 177 1.04e-01 -0.071000 2.49e-01
Trafficking of GluR2-containing AMPA receptors 14 6.48e-01 -0.070400 8.02e-01
Viral Messenger RNA Synthesis 44 4.20e-01 -0.070300 6.21e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 6.16e-01 -0.070200 7.81e-01
Regulation of actin dynamics for phagocytic cup formation 62 3.40e-01 0.070000 5.48e-01
Neuronal System 256 5.49e-02 0.069800 1.62e-01
MyD88 dependent cascade initiated on endosome 100 2.29e-01 0.069600 4.34e-01
Regulation of signaling by CBL 22 5.72e-01 0.069600 7.46e-01
RHOU GTPase cycle 39 4.54e-01 -0.069200 6.52e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 5.75e-01 0.069000 7.47e-01
Mitochondrial biogenesis 85 2.74e-01 0.068700 4.79e-01
Cell-cell junction organization 61 3.58e-01 0.068000 5.67e-01
HCMV Late Events 59 3.68e-01 0.067700 5.77e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 62 3.57e-01 0.067600 5.66e-01
CDC42 GTPase cycle 145 1.61e-01 -0.067400 3.43e-01
Antiviral mechanism by IFN-stimulated genes 79 3.01e-01 -0.067300 5.08e-01
Nonhomologous End-Joining (NHEJ) 34 5.00e-01 -0.066900 6.90e-01
Nitric oxide stimulates guanylate cyclase 16 6.44e-01 0.066700 8.00e-01
Sensory processing of sound by outer hair cells of the cochlea 35 4.96e-01 0.066600 6.88e-01
DAG and IP3 signaling 37 4.87e-01 -0.066100 6.79e-01
Regulation of NF-kappa B signaling 18 6.28e-01 0.066000 7.89e-01
FCERI mediated MAPK activation 33 5.12e-01 -0.066000 7.00e-01
Removal of the Flap Intermediate 14 6.75e-01 -0.064700 8.20e-01
Golgi Associated Vesicle Biogenesis 55 4.10e-01 0.064200 6.10e-01
Metabolism of water-soluble vitamins and cofactors 108 2.50e-01 0.064200 4.56e-01
Eicosanoid ligand-binding receptors 13 6.93e-01 -0.063300 8.31e-01
Other semaphorin interactions 19 6.33e-01 -0.063300 7.93e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.85e-01 0.063100 6.77e-01
RNA Polymerase III Transcription 41 4.85e-01 0.063100 6.77e-01
Class I MHC mediated antigen processing & presentation 344 4.56e-02 0.062900 1.45e-01
Transcriptional Regulation by VENTX 38 5.04e-01 0.062600 6.94e-01
Sema3A PAK dependent Axon repulsion 16 6.67e-01 -0.062200 8.16e-01
Regulation of CDH11 gene transcription 10 7.34e-01 0.062100 8.55e-01
Biotin transport and metabolism 11 7.23e-01 -0.061700 8.54e-01
MAP2K and MAPK activation 34 5.34e-01 -0.061600 7.19e-01
RAC3 GTPase cycle 85 3.28e-01 0.061400 5.36e-01
MyD88 deficiency (TLR2/4) 14 6.92e-01 -0.061200 8.31e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 7.37e-01 -0.061200 8.57e-01
Regulation of TP53 Activity through Phosphorylation 85 3.35e-01 0.060500 5.42e-01
Extension of Telomeres 49 4.64e-01 0.060500 6.61e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 5.86e-01 0.060500 7.53e-01
Glucose metabolism 81 3.47e-01 0.060500 5.53e-01
Condensation of Prophase Chromosomes 19 6.48e-01 -0.060500 8.02e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 101 2.96e-01 0.060200 5.01e-01
G beta:gamma signalling through PI3Kgamma 20 6.43e-01 -0.059800 8.00e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 5.24e-01 -0.059800 7.09e-01
Signaling by RAS mutants 38 5.24e-01 -0.059800 7.09e-01
Signaling by moderate kinase activity BRAF mutants 38 5.24e-01 -0.059800 7.09e-01
Signaling downstream of RAS mutants 38 5.24e-01 -0.059800 7.09e-01
Regulation of KIT signaling 15 6.90e-01 -0.059500 8.29e-01
E2F mediated regulation of DNA replication 21 6.39e-01 -0.059200 7.96e-01
Hyaluronan uptake and degradation 11 7.35e-01 -0.059000 8.55e-01
PRC2 methylates histones and DNA 19 6.57e-01 0.058900 8.08e-01
Regulation of TP53 Activity through Methylation 19 6.58e-01 0.058700 8.09e-01
G alpha (s) signalling events 84 3.55e-01 0.058500 5.63e-01
NOD1/2 Signaling Pathway 36 5.44e-01 -0.058500 7.27e-01
SUMOylation of DNA damage response and repair proteins 77 3.78e-01 -0.058200 5.80e-01
Regulation of HSF1-mediated heat shock response 78 3.75e-01 0.058100 5.79e-01
DNA Damage Bypass 45 5.03e-01 0.057700 6.93e-01
Sensory processing of sound 50 4.84e-01 0.057300 6.76e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 11 7.42e-01 -0.057300 8.61e-01
FLT3 Signaling 34 5.64e-01 0.057100 7.43e-01
Dual incision in TC-NER 65 4.28e-01 0.056900 6.27e-01
RHOQ GTPase cycle 57 4.58e-01 -0.056800 6.57e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 18 6.77e-01 0.056700 8.20e-01
Interleukin-6 signaling 10 7.57e-01 0.056400 8.70e-01
RUNX3 regulates NOTCH signaling 14 7.15e-01 -0.056400 8.49e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 13 7.26e-01 -0.056200 8.55e-01
Cargo trafficking to the periciliary membrane 45 5.15e-01 0.056100 7.03e-01
Heparan sulfate/heparin (HS-GAG) metabolism 43 5.25e-01 0.056100 7.10e-01
Vesicle-mediated transport 603 1.94e-02 0.056000 7.80e-02
Regulation of Expression and Function of Type II Classical Cadherins 29 6.03e-01 0.055800 7.66e-01
Regulation of Homotypic Cell-Cell Adhesion 29 6.03e-01 0.055800 7.66e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 4.67e-01 0.055800 6.61e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 4.67e-01 0.055800 6.61e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 4.67e-01 0.055800 6.61e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 4.67e-01 0.055800 6.61e-01
Signaling by NOTCH1 in Cancer 57 4.67e-01 0.055800 6.61e-01
Membrane Trafficking 571 2.40e-02 0.055500 9.06e-02
Retrograde transport at the Trans-Golgi-Network 49 5.03e-01 -0.055300 6.93e-01
Transcription of E2F targets under negative control by DREAM complex 18 6.85e-01 0.055300 8.25e-01
Synthesis of PC 23 6.48e-01 0.055100 8.02e-01
Immune System 1588 3.13e-04 0.054900 2.24e-03
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 7.13e-01 0.054800 8.48e-01
Toll Like Receptor 9 (TLR9) Cascade 104 3.36e-01 0.054700 5.43e-01
ADORA2B mediated anti-inflammatory cytokines production 35 5.76e-01 0.054600 7.47e-01
ISG15 antiviral mechanism 71 4.30e-01 -0.054200 6.28e-01
Reproduction 67 4.43e-01 0.054200 6.42e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 66 4.48e-01 -0.054100 6.46e-01
Interferon Signaling 165 2.34e-01 -0.053800 4.39e-01
Regulated Necrosis 51 5.07e-01 0.053800 6.95e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 7.21e-01 0.053200 8.54e-01
HDR through Single Strand Annealing (SSA) 35 5.89e-01 -0.052800 7.54e-01
Apoptotic execution phase 42 5.54e-01 0.052700 7.38e-01
HCMV Early Events 75 4.31e-01 0.052600 6.30e-01
MicroRNA (miRNA) biogenesis 24 6.57e-01 0.052400 8.08e-01
MET receptor recycling 10 7.74e-01 -0.052400 8.74e-01
Diseases associated with the TLR signaling cascade 27 6.39e-01 -0.052200 7.96e-01
Diseases of Immune System 27 6.39e-01 -0.052200 7.96e-01
G alpha (i) signalling events 171 2.43e-01 0.051800 4.49e-01
Opioid Signalling 77 4.33e-01 0.051800 6.30e-01
Heme signaling 44 5.53e-01 -0.051700 7.38e-01
PKA-mediated phosphorylation of CREB 19 6.97e-01 -0.051500 8.34e-01
Complement cascade 38 5.83e-01 0.051500 7.51e-01
RHOBTB GTPase Cycle 35 6.03e-01 0.050800 7.66e-01
Fcgamma receptor (FCGR) dependent phagocytosis 85 4.21e-01 0.050600 6.21e-01
PKA activation in glucagon signalling 16 7.26e-01 0.050500 8.55e-01
G beta:gamma signalling through PLC beta 15 7.35e-01 -0.050500 8.55e-01
Glyoxylate metabolism and glycine degradation 22 6.82e-01 0.050500 8.24e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 4.36e-01 0.050400 6.33e-01
Signaling by NOTCH1 70 4.66e-01 0.050400 6.61e-01
RNA polymerase II transcribes snRNA genes 71 4.64e-01 0.050300 6.61e-01
Transcriptional Regulation by MECP2 45 5.63e-01 0.049900 7.42e-01
PKA activation 17 7.23e-01 0.049700 8.54e-01
SLC-mediated transmembrane transport 151 2.92e-01 0.049700 4.99e-01
Synthesis of bile acids and bile salts 25 6.67e-01 -0.049700 8.16e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 6.76e-01 0.049300 8.20e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 6.76e-01 0.049300 8.20e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 24 6.76e-01 0.049300 8.20e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 24 6.76e-01 0.049300 8.20e-01
Signaling by FGFR1 in disease 32 6.30e-01 0.049200 7.90e-01
Diseases of programmed cell death 47 5.61e-01 0.049000 7.42e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 23 6.84e-01 -0.049000 8.24e-01
Trafficking of AMPA receptors 23 6.84e-01 -0.049000 8.24e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 6.98e-01 -0.049000 8.34e-01
RHOV GTPase cycle 34 6.22e-01 -0.048900 7.85e-01
Voltage gated Potassium channels 17 7.28e-01 -0.048800 8.55e-01
HDR through Homologous Recombination (HRR) 65 4.98e-01 -0.048600 6.89e-01
Effects of PIP2 hydrolysis 22 6.94e-01 -0.048400 8.32e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 7.64e-01 0.048200 8.70e-01
Metabolism of steroids 118 3.73e-01 0.047600 5.78e-01
SUMOylation of chromatin organization proteins 57 5.37e-01 -0.047300 7.23e-01
CRMPs in Sema3A signaling 14 7.60e-01 -0.047100 8.70e-01
G beta:gamma signalling through BTK 13 7.69e-01 0.047000 8.72e-01
Activated NOTCH1 Transmits Signal to the Nucleus 28 6.67e-01 0.047000 8.16e-01
Mitotic Spindle Checkpoint 103 4.11e-01 0.047000 6.10e-01
Transcriptional Regulation by E2F6 34 6.36e-01 0.046800 7.96e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 7.70e-01 -0.046800 8.73e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 86 4.54e-01 0.046800 6.52e-01
Amplification of signal from the kinetochores 86 4.54e-01 0.046800 6.52e-01
Interleukin-20 family signaling 14 7.62e-01 0.046700 8.70e-01
Listeria monocytogenes entry into host cells 18 7.32e-01 0.046600 8.55e-01
Glutathione conjugation 28 6.70e-01 0.046500 8.16e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 7.20e-01 -0.046300 8.54e-01
Adaptive Immune System 642 5.03e-02 0.045500 1.54e-01
Signaling by Rho GTPases 593 6.02e-02 0.045400 1.73e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 608 5.82e-02 0.045200 1.70e-01
RND3 GTPase cycle 36 6.40e-01 0.045000 7.98e-01
Pre-NOTCH Transcription and Translation 39 6.28e-01 0.044800 7.89e-01
Signaling by Retinoic Acid 36 6.44e-01 -0.044500 8.00e-01
SUMOylation of transcription cofactors 44 6.10e-01 0.044400 7.74e-01
RAC2 GTPase cycle 84 4.83e-01 0.044300 6.76e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 7.91e-01 -0.044200 8.85e-01
WNT ligand biogenesis and trafficking 16 7.59e-01 0.044200 8.70e-01
Processing of Capped Intronless Pre-mRNA 29 6.80e-01 -0.044200 8.23e-01
HDACs deacetylate histones 36 6.49e-01 0.043900 8.02e-01
Signaling by NTRK3 (TRKC) 16 7.61e-01 0.043900 8.70e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 5.78e-01 0.043800 7.47e-01
Killing mechanisms 10 8.11e-01 0.043700 8.98e-01
WNT5:FZD7-mediated leishmania damping 10 8.11e-01 0.043700 8.98e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.11e-01 0.043600 8.98e-01
HDMs demethylate histones 21 7.30e-01 -0.043400 8.55e-01
Pregnenolone biosynthesis 10 8.13e-01 -0.043300 8.98e-01
Acyl chain remodelling of PG 11 8.05e-01 -0.043100 8.96e-01
FOXO-mediated transcription of cell death genes 15 7.73e-01 0.043000 8.74e-01
Formation of annular gap junctions 11 8.06e-01 -0.042800 8.96e-01
mRNA Splicing 210 2.89e-01 0.042500 4.96e-01
Semaphorin interactions 61 5.68e-01 0.042300 7.43e-01
Signaling by Nuclear Receptors 214 2.91e-01 0.041900 4.98e-01
Processing of DNA double-strand break ends 60 5.77e-01 0.041600 7.47e-01
mRNA Splicing - Major Pathway 202 3.11e-01 0.041400 5.19e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 7.81e-01 0.041400 8.78e-01
RNA Polymerase I Promoter Escape 37 6.66e-01 0.041100 8.16e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 65 5.67e-01 0.041000 7.43e-01
Thrombin signalling through proteinase activated receptors (PARs) 25 7.23e-01 0.040900 8.54e-01
SUMO E3 ligases SUMOylate target proteins 161 3.72e-01 -0.040900 5.78e-01
Endogenous sterols 20 7.56e-01 0.040100 8.70e-01
DNA strand elongation 31 7.00e-01 0.040000 8.35e-01
RHOJ GTPase cycle 52 6.19e-01 0.039800 7.84e-01
Recruitment of NuMA to mitotic centrosomes 86 5.24e-01 0.039800 7.09e-01
Regulation of beta-cell development 18 7.73e-01 -0.039300 8.74e-01
Organelle biogenesis and maintenance 270 2.68e-01 0.039300 4.73e-01
Positive epigenetic regulation of rRNA expression 52 6.26e-01 0.039100 7.89e-01
Glycolysis 64 5.89e-01 0.039100 7.54e-01
Transcriptional activation of mitochondrial biogenesis 49 6.37e-01 -0.039000 7.96e-01
Signal transduction by L1 20 7.63e-01 0.038900 8.70e-01
RET signaling 33 6.99e-01 0.038800 8.35e-01
Scavenging by Class A Receptors 16 7.90e-01 -0.038500 8.85e-01
Thromboxane signalling through TP receptor 19 7.73e-01 0.038200 8.74e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23 7.55e-01 0.037600 8.70e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 85 5.54e-01 -0.037200 7.38e-01
DNA Repair 279 2.94e-01 0.036600 5.00e-01
Phosphorylation of the APC/C 20 7.77e-01 -0.036500 8.76e-01
Intra-Golgi traffic 42 6.83e-01 -0.036500 8.24e-01
Telomere C-strand (Lagging Strand) Synthesis 34 7.13e-01 0.036400 8.48e-01
PCNA-Dependent Long Patch Base Excision Repair 21 7.73e-01 0.036300 8.74e-01
Integrin signaling 22 7.69e-01 -0.036100 8.72e-01
Aflatoxin activation and detoxification 11 8.38e-01 0.035700 9.09e-01
Negative regulation of the PI3K/AKT network 87 5.66e-01 0.035600 7.43e-01
RHOD GTPase cycle 49 6.68e-01 0.035500 8.16e-01
EPH-Ephrin signaling 82 5.84e-01 0.035000 7.51e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 22 7.77e-01 0.034900 8.76e-01
SUMOylation of RNA binding proteins 47 6.82e-01 -0.034600 8.24e-01
RAB GEFs exchange GTP for GDP on RABs 86 5.84e-01 0.034200 7.51e-01
Constitutive Signaling by Overexpressed ERBB2 11 8.44e-01 -0.034200 9.13e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 7.48e-01 -0.033900 8.63e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 8.47e-01 -0.033600 9.13e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 8.16e-01 0.033600 8.99e-01
Striated Muscle Contraction 20 7.97e-01 0.033200 8.89e-01
Signaling by BRAF and RAF1 fusions 56 6.70e-01 -0.033000 8.16e-01
Signaling by EGFR 46 6.99e-01 -0.033000 8.35e-01
Diseases associated with N-glycosylation of proteins 20 7.99e-01 0.032900 8.91e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 36 7.33e-01 -0.032900 8.55e-01
Citric acid cycle (TCA cycle) 22 7.90e-01 0.032700 8.85e-01
Signaling by ERBB2 47 7.01e-01 0.032400 8.36e-01
Cytochrome P450 - arranged by substrate type 33 7.48e-01 0.032300 8.63e-01
Deadenylation-dependent mRNA decay 50 6.94e-01 0.032200 8.32e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 7.21e-01 -0.032200 8.54e-01
SLC transporter disorders 69 6.46e-01 -0.032000 8.02e-01
Fatty acid metabolism 140 5.16e-01 0.031800 7.04e-01
Binding and Uptake of Ligands by Scavenger Receptors 35 7.45e-01 0.031800 8.62e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 8.31e-01 0.031800 9.09e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.16e-01 -0.031700 8.99e-01
Nicotinate metabolism 27 7.76e-01 0.031700 8.75e-01
Adenylate cyclase inhibitory pathway 13 8.43e-01 0.031700 9.13e-01
Frs2-mediated activation 12 8.50e-01 -0.031500 9.14e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.09e-01 -0.031300 8.98e-01
Cell death signalling via NRAGE, NRIF and NADE 73 6.46e-01 -0.031100 8.02e-01
Aspirin ADME 15 8.35e-01 -0.031100 9.09e-01
Synthesis of PA 31 7.65e-01 -0.031000 8.71e-01
Apoptotic cleavage of cellular proteins 34 7.56e-01 0.030800 8.70e-01
The role of Nef in HIV-1 replication and disease pathogenesis 24 7.95e-01 -0.030600 8.88e-01
SARS-CoV-1 activates/modulates innate immune responses 39 7.42e-01 0.030400 8.61e-01
Germ layer formation at gastrulation 10 8.68e-01 -0.030300 9.20e-01
Signaling by GPCR 396 3.04e-01 0.030200 5.11e-01
SUMOylation 167 5.01e-01 -0.030200 6.92e-01
NoRC negatively regulates rRNA expression 52 7.14e-01 0.029400 8.48e-01
Oncogenic MAPK signaling 72 6.70e-01 -0.029000 8.16e-01
Signalling to RAS 20 8.23e-01 0.028900 9.05e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 8.52e-01 0.028800 9.15e-01
ERK/MAPK targets 22 8.16e-01 0.028700 8.99e-01
Intrinsic Pathway for Apoptosis 52 7.21e-01 0.028700 8.54e-01
Role of phospholipids in phagocytosis 26 8.01e-01 -0.028600 8.92e-01
SUMOylation of transcription factors 17 8.42e-01 -0.027900 9.12e-01
Retrograde neurotrophin signalling 14 8.60e-01 0.027300 9.17e-01
Acyl chain remodelling of PS 14 8.60e-01 -0.027200 9.17e-01
NOTCH3 Intracellular Domain Regulates Transcription 21 8.30e-01 0.027100 9.09e-01
p75 NTR receptor-mediated signalling 92 6.53e-01 0.027100 8.06e-01
TP53 Regulates Transcription of Cell Death Genes 40 7.68e-01 -0.027000 8.72e-01
Mitochondrial tRNA aminoacylation 21 8.31e-01 -0.026900 9.09e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 94 6.52e-01 -0.026900 8.05e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 8.73e-01 0.026800 9.22e-01
Regulation of PLK1 Activity at G2/M Transition 85 6.71e-01 0.026700 8.16e-01
Toll-like Receptor Cascades 155 5.69e-01 0.026500 7.44e-01
Diseases of DNA repair 48 7.51e-01 0.026400 8.66e-01
FOXO-mediated transcription 56 7.34e-01 0.026200 8.55e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 8.35e-01 -0.026200 9.09e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 8.35e-01 -0.026200 9.09e-01
RNA Polymerase I Promoter Clearance 56 7.36e-01 0.026100 8.55e-01
RNA Polymerase I Transcription 56 7.36e-01 0.026100 8.55e-01
Regulation of PTEN mRNA translation 11 8.81e-01 0.026000 9.29e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 8.44e-01 -0.026000 9.13e-01
Metabolism of non-coding RNA 53 7.46e-01 -0.025800 8.62e-01
snRNP Assembly 53 7.46e-01 -0.025800 8.62e-01
EPH-ephrin mediated repulsion of cells 44 7.68e-01 -0.025700 8.72e-01
Peroxisomal protein import 57 7.38e-01 -0.025600 8.57e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 8.68e-01 0.025600 9.20e-01
Signaling by EGFR in Cancer 22 8.37e-01 -0.025400 9.09e-01
FCGR3A-mediated phagocytosis 60 7.35e-01 0.025300 8.55e-01
Leishmania phagocytosis 60 7.35e-01 0.025300 8.55e-01
Parasite infection 60 7.35e-01 0.025300 8.55e-01
Cilium Assembly 185 5.55e-01 0.025200 7.38e-01
Establishment of Sister Chromatid Cohesion 11 8.85e-01 -0.025100 9.33e-01
RND2 GTPase cycle 36 7.95e-01 -0.025000 8.88e-01
Impaired BRCA2 binding to PALB2 23 8.36e-01 0.025000 9.09e-01
Signaling by ERBB4 50 7.62e-01 -0.024700 8.70e-01
Gene expression (Transcription) 1343 1.33e-01 -0.024700 3.01e-01
Sulfur amino acid metabolism 23 8.38e-01 0.024700 9.09e-01
Cargo recognition for clathrin-mediated endocytosis 91 6.86e-01 -0.024600 8.25e-01
RHO GTPases Activate NADPH Oxidases 21 8.47e-01 0.024300 9.13e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 8.95e-01 0.024100 9.38e-01
SUMOylation of intracellular receptors 27 8.29e-01 -0.024000 9.09e-01
Signaling by NTRK2 (TRKB) 21 8.50e-01 -0.023900 9.14e-01
Mitotic Prometaphase 186 5.82e-01 0.023400 7.51e-01
AURKA Activation by TPX2 70 7.36e-01 -0.023400 8.55e-01
Expression and translocation of olfactory receptors 23 8.48e-01 0.023000 9.13e-01
FCERI mediated Ca+2 mobilization 32 8.22e-01 -0.022900 9.05e-01
Gene Silencing by RNA 78 7.33e-01 -0.022300 8.55e-01
ADP signalling through P2Y purinoceptor 1 20 8.63e-01 0.022300 9.17e-01
Inositol phosphate metabolism 41 8.14e-01 -0.021300 8.99e-01
Netrin-1 signaling 41 8.16e-01 0.021000 8.99e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 8.48e-01 0.020900 9.13e-01
Drug ADME 59 7.87e-01 0.020300 8.84e-01
Signaling by NODAL 13 9.00e-01 0.020200 9.40e-01
Termination of translesion DNA synthesis 31 8.46e-01 0.020100 9.13e-01
Signal regulatory protein family interactions 11 9.09e-01 0.019900 9.45e-01
Costimulation by the CD28 family 48 8.12e-01 0.019800 8.98e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.64e-01 0.019800 9.17e-01
VEGFR2 mediated vascular permeability 27 8.60e-01 0.019700 9.17e-01
Dual Incision in GG-NER 41 8.28e-01 -0.019600 9.09e-01
Centrosome maturation 79 7.64e-01 -0.019600 8.70e-01
Recruitment of mitotic centrosome proteins and complexes 79 7.64e-01 -0.019600 8.70e-01
tRNA processing in the nucleus 59 7.95e-01 -0.019600 8.88e-01
TP53 Regulates Transcription of Cell Cycle Genes 44 8.24e-01 0.019400 9.06e-01
Clathrin-mediated endocytosis 130 7.11e-01 -0.018800 8.47e-01
G0 and Early G1 25 8.72e-01 -0.018700 9.22e-01
Prolactin receptor signaling 11 9.15e-01 -0.018500 9.50e-01
TNF signaling 57 8.10e-01 -0.018400 8.98e-01
Arachidonic acid metabolism 37 8.48e-01 0.018200 9.13e-01
Glutamate Neurotransmitter Release Cycle 21 8.86e-01 0.018100 9.33e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 8.98e-01 0.017900 9.40e-01
G alpha (q) signalling events 128 7.27e-01 -0.017900 8.55e-01
Regulation of TNFR1 signaling 48 8.32e-01 0.017700 9.09e-01
Pyroptosis 21 8.89e-01 -0.017500 9.35e-01
CD28 dependent PI3K/Akt signaling 20 8.93e-01 0.017400 9.37e-01
Processing of Capped Intron-Containing Pre-mRNA 278 6.20e-01 -0.017300 7.85e-01
Glycerophospholipid biosynthesis 100 7.65e-01 -0.017300 8.71e-01
RHOB GTPase cycle 64 8.11e-01 -0.017300 8.98e-01
RNA Polymerase I Transcription Termination 30 8.72e-01 0.017000 9.22e-01
p130Cas linkage to MAPK signaling for integrins 11 9.23e-01 0.016900 9.56e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 8.59e-01 0.016700 9.17e-01
Homology Directed Repair 100 7.78e-01 -0.016300 8.76e-01
ZBP1(DAI) mediated induction of type I IFNs 19 9.03e-01 0.016200 9.42e-01
Homologous DNA Pairing and Strand Exchange 41 8.60e-01 -0.015900 9.17e-01
CD28 co-stimulation 30 8.82e-01 0.015700 9.29e-01
RNA Polymerase II Transcription 1185 3.72e-01 -0.015500 5.78e-01
Generic Transcription Pathway 1067 3.97e-01 -0.015500 5.98e-01
TNFR1-induced NF-kappa-B signaling pathway 33 8.78e-01 -0.015400 9.27e-01
Plasma lipoprotein remodeling 19 9.08e-01 -0.015400 9.45e-01
Anti-inflammatory response favouring Leishmania parasite infection 70 8.34e-01 -0.014500 9.09e-01
Leishmania parasite growth and survival 70 8.34e-01 -0.014500 9.09e-01
NCAM signaling for neurite out-growth 49 8.61e-01 -0.014400 9.17e-01
RAC1 GTPase cycle 172 7.45e-01 -0.014400 8.62e-01
tRNA modification in the nucleus and cytosol 43 8.70e-01 0.014400 9.21e-01
Leishmania infection 149 7.63e-01 0.014300 8.70e-01
Parasitic Infection Pathways 149 7.63e-01 0.014300 8.70e-01
trans-Golgi Network Vesicle Budding 70 8.38e-01 -0.014200 9.09e-01
Regulation of CDH11 Expression and Function 27 9.01e-01 0.013800 9.41e-01
G2/M DNA damage checkpoint 57 8.58e-01 0.013700 9.17e-01
Depolymerization of the Nuclear Lamina 15 9.28e-01 -0.013500 9.59e-01
Resolution of Abasic Sites (AP sites) 38 8.87e-01 0.013400 9.33e-01
RHO GTPases activate KTN1 10 9.42e-01 -0.013200 9.66e-01
Transcriptional regulation by small RNAs 53 8.69e-01 -0.013100 9.20e-01
RHOBTB1 GTPase cycle 23 9.14e-01 -0.013000 9.49e-01
Activation of HOX genes during differentiation 65 8.56e-01 0.013000 9.17e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 65 8.56e-01 0.013000 9.17e-01
G beta:gamma signalling through CDC42 15 9.31e-01 0.012900 9.61e-01
Postmitotic nuclear pore complex (NPC) reformation 27 9.08e-01 0.012800 9.45e-01
Advanced glycosylation endproduct receptor signaling 11 9.42e-01 -0.012700 9.66e-01
Impaired BRCA2 binding to RAD51 33 9.00e-01 -0.012700 9.40e-01
Loss of Nlp from mitotic centrosomes 67 8.64e-01 -0.012100 9.17e-01
Loss of proteins required for interphase microtubule organization from the centrosome 67 8.64e-01 -0.012100 9.17e-01
Nuclear Receptor transcription pathway 40 8.95e-01 0.012100 9.38e-01
Neurexins and neuroligins 40 8.95e-01 0.012000 9.38e-01
Negative regulation of MET activity 20 9.27e-01 -0.011800 9.59e-01
Carnitine metabolism 13 9.42e-01 0.011700 9.66e-01
HATs acetylate histones 82 8.57e-01 0.011500 9.17e-01
Chromatin modifying enzymes 202 7.88e-01 -0.011000 8.84e-01
Chromatin organization 202 7.88e-01 -0.011000 8.84e-01
Polymerase switching on the C-strand of the telomere 26 9.23e-01 0.010900 9.56e-01
GPCR downstream signalling 356 7.29e-01 0.010700 8.55e-01
Regulation of lipid metabolism by PPARalpha 106 8.55e-01 -0.010300 9.17e-01
RHOA GTPase cycle 141 8.36e-01 -0.010100 9.09e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 9.29e-01 -0.010100 9.59e-01
Synthesis of IP3 and IP4 in the cytosol 22 9.36e-01 0.009930 9.63e-01
Rab regulation of trafficking 118 8.52e-01 -0.009920 9.15e-01
Surfactant metabolism 19 9.47e-01 0.008800 9.70e-01
Activation of ATR in response to replication stress 31 9.33e-01 0.008690 9.62e-01
GPVI-mediated activation cascade 31 9.38e-01 0.008100 9.63e-01
Glycosphingolipid metabolism 36 9.34e-01 0.007970 9.62e-01
RNA Polymerase I Transcription Initiation 47 9.27e-01 0.007710 9.59e-01
Disorders of Developmental Biology 11 9.65e-01 0.007680 9.80e-01
Disorders of Nervous System Development 11 9.65e-01 0.007680 9.80e-01
Loss of function of MECP2 in Rett syndrome 11 9.65e-01 0.007680 9.80e-01
Pervasive developmental disorders 11 9.65e-01 0.007680 9.80e-01
Signaling by VEGF 104 8.94e-01 -0.007570 9.38e-01
Triglyceride metabolism 24 9.49e-01 0.007490 9.72e-01
Anchoring of the basal body to the plasma membrane 95 9.05e-01 -0.007080 9.44e-01
O-linked glycosylation 85 9.12e-01 -0.006950 9.47e-01
HDR through MMEJ (alt-NHEJ) 12 9.67e-01 0.006930 9.80e-01
Synthesis of PIPs at the plasma membrane 50 9.37e-01 0.006500 9.63e-01
Interaction between L1 and Ankyrins 22 9.58e-01 -0.006470 9.79e-01
Nicotinamide salvaging 16 9.65e-01 -0.006370 9.80e-01
Deadenylation of mRNA 22 9.63e-01 -0.005760 9.80e-01
Death Receptor Signaling 148 9.06e-01 0.005650 9.44e-01
Metabolism of lipids 596 8.33e-01 0.005090 9.09e-01
Cell recruitment (pro-inflammatory response) 24 9.66e-01 0.004970 9.80e-01
Purinergic signaling in leishmaniasis infection 24 9.66e-01 0.004970 9.80e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 9.59e-01 0.004750 9.79e-01
Diseases of DNA Double-Strand Break Repair 39 9.59e-01 0.004750 9.79e-01
Presynaptic function of Kainate receptors 16 9.75e-01 0.004450 9.86e-01
EGFR downregulation 27 9.68e-01 -0.004430 9.80e-01
Signaling by SCF-KIT 39 9.64e-01 0.004220 9.80e-01
DNA Double-Strand Break Repair 129 9.36e-01 -0.004080 9.63e-01
eNOS activation 11 9.83e-01 0.003660 9.93e-01
VEGFA-VEGFR2 Pathway 95 9.60e-01 -0.003010 9.79e-01
RHO GTPase cycle 415 9.23e-01 0.002790 9.56e-01
Ion channel transport 129 9.57e-01 0.002720 9.79e-01
G-protein activation 18 9.88e-01 0.002110 9.93e-01
Prolonged ERK activation events 14 9.90e-01 0.002010 9.93e-01
tRNA processing 109 9.74e-01 -0.001830 9.85e-01
Plasma lipoprotein clearance 33 9.86e-01 -0.001750 9.93e-01
Negative epigenetic regulation of rRNA expression 55 9.84e-01 -0.001610 9.93e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 30 9.88e-01 0.001540 9.93e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 55 9.84e-01 0.001520 9.93e-01
Interferon alpha/beta signaling 57 9.84e-01 0.001500 9.93e-01
RHOF GTPase cycle 38 9.89e-01 -0.001280 9.93e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 9.88e-01 0.001130 9.93e-01
B-WICH complex positively regulates rRNA expression 37 9.91e-01 -0.001090 9.94e-01
RHOC GTPase cycle 69 9.89e-01 -0.000924 9.93e-01
Regulation of innate immune responses to cytosolic DNA 13 9.96e-01 0.000773 9.96e-01
Mitotic Prophase 88 9.92e-01 -0.000602 9.94e-01
PPARA activates gene expression 104 9.93e-01 0.000499 9.94e-01
Signalling to ERKs 33 9.96e-01 -0.000456 9.96e-01


Detailed Gene set reports



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
370
set Eukaryotic Translation Elongation
setSize 91
pANOVA 1.75e-32
s.dist 0.719
p.adjustANOVA 5.13e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
EEF1B2 7515
RPL36 7508
RPL5 7478
EEF2 7470
RPS5 7459
RPS6 7412
RPS8 7411

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
EEF1B2 7515
RPL36 7508
RPL5 7478
EEF2 7470
RPS5 7459
RPS6 7412
RPS8 7411
EEF1G 7385
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
EEF1D 6985
RPL15 6959
EEF1A1P5 6931
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
EEF1A1 6422
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
RPL36A 3707
RPS27L 3593
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
RPS26 -3603


Peptide chain elongation

Peptide chain elongation
850
set Peptide chain elongation
setSize 87
pANOVA 1.19e-30
s.dist 0.713
p.adjustANOVA 1.75e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
EEF2 7470
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
EEF2 7470
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
EEF1A1 6422
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
RPL36A 3707
RPS27L 3593
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
RPS26 -3603


Viral mRNA Translation

Viral mRNA Translation
1417
set Viral mRNA Translation
setSize 87
pANOVA 4.76e-30
s.dist 0.705
p.adjustANOVA 6.34e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
RPL14 5533
GRSF1 5531
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
RPL36A 3707
RPS27L 3593
DNAJC3 3095
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
RPS26 -3603


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
414
set Formation of a pool of free 40S subunits
setSize 99
pANOVA 4.49e-32
s.dist 0.685
p.adjustANOVA 8.21e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
EIF3I 7883
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
EIF3I 7883
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF3A 7011
RPL13 7009
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
EIF3C 6567
RPS29 6566
RPL32 6545
EIF3L 6537
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
EIF3F 5549
RPL14 5533
EIF3E 5427
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
EIF3D 4876
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
RPL36A 3707
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF3K 2031
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
EIF3B 1081
EIF1AX -2134
RPS26 -3603


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1092
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 1.35e-12
s.dist 0.682
p.adjustANOVA 4.6e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS19 7955
RPS3 7856
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
RPS11 7228
RPS2 7195
FAU 7160
RPS15 7091
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739
RPS29 6566
EEF1A1 6422
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS19 7955
RPS3 7856
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
RPS11 7228
RPS2 7195
FAU 7160
RPS15 7091
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739
RPS29 6566
EEF1A1 6422
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
HNRNPA1 5390
RPS21 5369
RPS16 5037
RPS20 4668
RPS14 4569
RPS27L 3593
RPS4Y1 1834
RPS26 -3603


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
782
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 93
pANOVA 1.43e-29
s.dist 0.677
p.adjustANOVA 1.74e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
GSPT1 5769
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ETF1 5555
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
NCBP2 4271
RPL36A 3707
RPS27L 3593
PABPC1 2170
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
UPF1 792
GSPT2 170
NCBP1 -364
RPS26 -3603


Eukaryotic Translation Termination

Eukaryotic Translation Termination
372
set Eukaryotic Translation Termination
setSize 91
pANOVA 1.13e-28
s.dist 0.673
p.adjustANOVA 1.18e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
GSPT1 5769
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ETF1 5555
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
TRMT112 4285
RPL36A 3707
RPS27L 3593
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
APEH 278
GSPT2 170
RPS26 -3603
N6AMT1 -7350


Formation of tubulin folding intermediates by CCT/TriC

Formation of tubulin folding intermediates by CCT/TriC
424
set Formation of tubulin folding intermediates by CCT/TriC
setSize 20
pANOVA 2.11e-07
s.dist 0.67
p.adjustANOVA 3.4e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TCP1 8092
CCT6A 7866
CCT7 7846
CCT4 7711
TUBA1C 7408
CCT6B 6803
CCT3 6460
CCT2 6386
TUBA1B 6282
TUBB4B 5985
TUBAL3 5741
TUBB2B 4999
TUBA1A 3673
TUBB6 3486
CCT8 3425
TUBA8 2868
TUBB3 2464
CCT5 2207

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TCP1 8092
CCT6A 7866
CCT7 7846
CCT4 7711
TUBA1C 7408
CCT6B 6803
CCT3 6460
CCT2 6386
TUBA1B 6282
TUBB4B 5985
TUBAL3 5741
TUBB2B 4999
TUBA1A 3673
TUBB6 3486
CCT8 3425
TUBA8 2868
TUBB3 2464
CCT5 2207


Selenocysteine synthesis

Selenocysteine synthesis
1138
set Selenocysteine synthesis
setSize 91
pANOVA 3.37e-28
s.dist 0.667
p.adjustANOVA 2.9e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
SARS1 6962
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
PSTK 4376
RPL36A 3707
RPS27L 3593
EEFSEC 2815
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
SEPHS2 1467
RPS26 -3603
SEPSECS -5068
SECISBP2 -6240


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
623
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 109
pANOVA 2.15e-33
s.dist 0.667
p.adjustANOVA 1.05e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF3A 7011
RPL13 7009
RPL15 6959
EIF4H 6951
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
EIF3C 6567
RPS29 6566
RPL32 6545
EIF3L 6537
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
EIF3F 5549
RPL14 5533
EIF3E 5427
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
EIF3D 4876
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
EIF4A1 4003
RPL36A 3707
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
PABPC1 2170
EIF3K 2031
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
EIF3B 1081
EIF4E 687
EIF2S3 281
EIF1AX -2134
RPS26 -3603


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
461
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 110
pANOVA 7.05e-33
s.dist 0.658
p.adjustANOVA 2.58e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF3A 7011
RPL13 7009
RPL15 6959
EIF4H 6951
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
EIF3C 6567
RPS29 6566
RPL32 6545
EIF3L 6537
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
EIF3F 5549
RPL14 5533
EIF3E 5427
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
EIF3D 4876
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
EIF4A1 4003
RPL36A 3707
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
EIF3K 2031
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
EIF3B 1081
EIF4E 687
EIF5 366
EIF2S3 281
EIF5B -22
EIF1AX -2134
RPS26 -3603


Folding of actin by CCT/TriC

Folding of actin by CCT/TriC
404
set Folding of actin by CCT/TriC
setSize 10
pANOVA 0.000384
s.dist 0.648
p.adjustANOVA 0.00267



Top enriched genes

Top 20 genes
GeneID Gene Rank
TCP1 8092
CCT6A 7866
CCT7 7846
CCT4 7711
CCT6B 6803
CCT3 6460
CCT2 6386
CCT8 3425
CCT5 2207
ACTB -345

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCP1 8092
CCT6A 7866
CCT7 7846
CCT4 7711
CCT6B 6803
CCT3 6460
CCT2 6386
CCT8 3425
CCT5 2207
ACTB -345


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1117
set SRP-dependent cotranslational protein targeting to membrane
setSize 110
pANOVA 1.21e-31
s.dist 0.645
p.adjustANOVA 1.96e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
SSR4 8445
RPL3 8213
RPLP0 8195
SSR2 8090
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
SRP68 7501
RPL5 7478
SRPRA 7477
RPS5 7459

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SSR4 8445
RPL3 8213
RPLP0 8195
SSR2 8090
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
SRP68 7501
RPL5 7478
SRPRA 7477
RPS5 7459
RPS6 7412
RPS8 7411
SRP54 7238
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
RPN1 6897
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
SSR3 6579
RPS29 6566
RPL32 6545
DDOST 6522
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
SEC11C 6265
RPL34 6202
RPS10 6082
SEC61B 6081
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
SSR1 5894
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
SEC11A 4959
RPL21 4774
RPL38 4758
RPL35 4688
SRPRB 4673
RPS20 4668
RPS14 4569
RPL24 4535
RPL36A 3707
RPS27L 3593
SPCS2 3211
RPN2 3032
TRAM1 2399
SRP72 2191
RPL22L1 2027
RPS4Y1 1834
SPCS3 1674
RPL9 1672
SRP14 1061
SEC61A1 892
SEC61G 572
SPCS1 -729
SRP19 -842
SRP9 -1159
RPS26 -3603
SEC61A2 -5327


Prefoldin mediated transfer of substrate to CCT/TriC

Prefoldin mediated transfer of substrate to CCT/TriC
891
set Prefoldin mediated transfer of substrate to CCT/TriC
setSize 24
pANOVA 6.78e-08
s.dist 0.636
p.adjustANOVA 1.38e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TCP1 8092
CCT6A 7866
CCT7 7846
PFDN2 7815
CCT4 7711
TUBA1C 7408
PFDN5 7033
CCT6B 6803
CCT3 6460
CCT2 6386
TUBB4B 5985
PFDN1 5844
VBP1 5257
TUBB2B 4999
PFDN6 4015
TUBA1A 3673
TUBB6 3486
CCT8 3425

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TCP1 8092
CCT6A 7866
CCT7 7846
PFDN2 7815
CCT4 7711
TUBA1C 7408
PFDN5 7033
CCT6B 6803
CCT3 6460
CCT2 6386
TUBB4B 5985
PFDN1 5844
VBP1 5257
TUBB2B 4999
PFDN6 4015
TUBA1A 3673
TUBB6 3486
CCT8 3425
TUBB3 2464
CCT5 2207
PFDN4 1856
ACTB -345


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
423
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 4.1e-15
s.dist 0.635
p.adjustANOVA 1.54e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739
EIF3C 6567
RPS29 6566
EIF3L 6537
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
EIF3F 5549
EIF3E 5427
RPS21 5369
RPS16 5037
EIF3D 4876
RPS20 4668
RPS14 4569
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF3K 2031
RPS4Y1 1834
EIF3B 1081
EIF2S3 281
EIF1AX -2134
RPS26 -3603


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1078
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 99
pANOVA 1.17e-27
s.dist 0.633
p.adjustANOVA 9.49e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATF3 8509
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
ATF4 7924
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF3 8509
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
ATF4 7924
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
CEBPB 6582
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
RPL36A 3707
RPS27L 3593
CEBPG 2356
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
IMPACT 597
EIF2S3 281
TRIB3 -1153
EIF2AK4 -1649
ATF2 -2809
ASNS -2937
RPS26 -3603
DDIT3 -5113
GCN1 -5596


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
153
set Cap-dependent Translation Initiation
setSize 117
pANOVA 3.73e-32
s.dist 0.631
p.adjustANOVA 7.8e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
EIF2B2 7334
EIF3H 7284
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF3A 7011
RPL13 7009
RPL15 6959
EIF4H 6951
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
EIF3C 6567
RPS29 6566
RPL32 6545
EIF3L 6537
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
EIF3F 5549
RPL14 5533
EIF3E 5427
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
EIF3D 4876
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
EIF2B3 4528
EIF4A1 4003
RPL36A 3707
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
PABPC1 2170
EIF3K 2031
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
EIF3B 1081
EIF4E 687
EIF5 366
EIF2S3 281
EIF5B -22
EIF2B4 -157
EIF1AX -2134
RPS26 -3603
EIF2B5 -3891
EIF2B1 -4304


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
371
set Eukaryotic Translation Initiation
setSize 117
pANOVA 3.73e-32
s.dist 0.631
p.adjustANOVA 7.8e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
EIF2S2 8075
RPS19 7955
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
EIF2B2 7334
EIF3H 7284
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF3A 7011
RPL13 7009
RPL15 6959
EIF4H 6951
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
EIF3C 6567
RPS29 6566
RPL32 6545
EIF3L 6537
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
EIF3F 5549
RPL14 5533
EIF3E 5427
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
EIF3D 4876
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
EIF2B3 4528
EIF4A1 4003
RPL36A 3707
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
PABPC1 2170
EIF3K 2031
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
EIF3B 1081
EIF4E 687
EIF5 366
EIF2S3 281
EIF5B -22
EIF2B4 -157
EIF1AX -2134
RPS26 -3603
EIF2B5 -3891
EIF2B1 -4304


Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
695
set Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
setSize 12
pANOVA 0.000157
s.dist 0.63
p.adjustANOVA 0.00121



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TUBA1C 7408
GJA1 6327
TUBA1B 6282
TUBB4B 5985
TUBAL3 5741
TUBB2B 4999
TUBA1A 3673
TUBB6 3486
TUBA8 2868
TUBB3 2464

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TUBA1C 7408
GJA1 6327
TUBA1B 6282
TUBB4B 5985
TUBAL3 5741
TUBB2B 4999
TUBA1A 3673
TUBB6 3486
TUBA8 2868
TUBB3 2464


Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
226
set Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
setSize 27
pANOVA 1.56e-08
s.dist 0.629
p.adjustANOVA 3.81e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TCP1 8092
CCT6A 7866
CCT7 7846
PFDN2 7815
CCT4 7711
TUBA1C 7408
PFDN5 7033
CCT6B 6803
CCT3 6460
CCT2 6386
TUBA1B 6282
TUBB4B 5985
PFDN1 5844
TUBAL3 5741
VBP1 5257
TUBB2B 4999
PFDN6 4015
TUBA1A 3673

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TCP1 8092
CCT6A 7866
CCT7 7846
PFDN2 7815
CCT4 7711
TUBA1C 7408
PFDN5 7033
CCT6B 6803
CCT3 6460
CCT2 6386
TUBA1B 6282
TUBB4B 5985
PFDN1 5844
TUBAL3 5741
VBP1 5257
TUBB2B 4999
PFDN6 4015
TUBA1A 3673
TUBB6 3486
CCT8 3425
TUBA8 2868
TUBB3 2464
CCT5 2207
PFDN4 1856
ACTB -345


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
50
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 2.82e-16
s.dist 0.615
p.adjustANOVA 1.18e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
EIF4H 6951
RPS18 6831
RPS28 6826

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
EIF4H 6951
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739
EIF3C 6567
RPS29 6566
EIF3L 6537
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
EIF3F 5549
EIF3E 5427
RPS21 5369
RPS16 5037
EIF3D 4876
EIF4G1 4736
RPS20 4668
RPS14 4569
EIF4A1 4003
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
PABPC1 2170
EIF3K 2031
RPS4Y1 1834
EIF3B 1081
EIF4E 687
EIF2S3 281
EIF1AX -2134
RPS26 -3603


Translation initiation complex formation

Translation initiation complex formation
1369
set Translation initiation complex formation
setSize 58
pANOVA 8.92e-16
s.dist 0.61
p.adjustANOVA 3.53e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
EIF4H 6951
RPS18 6831
RPS28 6826
RPS13 6748

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
EIF4H 6951
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739
EIF3C 6567
RPS29 6566
EIF3L 6537
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
EIF3F 5549
EIF3E 5427
RPS21 5369
RPS16 5037
EIF3D 4876
EIF4G1 4736
RPS20 4668
RPS14 4569
EIF4A1 4003
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
PABPC1 2170
EIF3K 2031
RPS4Y1 1834
EIF3B 1081
EIF4E 687
EIF2S3 281
EIF1AX -2134
RPS26 -3603


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1085
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 1.34e-15
s.dist 0.606
p.adjustANOVA 5.17e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
EIF4H 6951
RPS18 6831
RPS28 6826
RPS13 6748

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S2 8075
RPS19 7955
EIF3I 7883
RPS3 7856
EIF2S1 7768
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
EIF3H 7284
RPS11 7228
RPS2 7195
FAU 7160
EIF3G 7137
RPS15 7091
EIF3A 7011
EIF4H 6951
RPS18 6831
RPS28 6826
RPS13 6748
RPS12 6739
EIF3C 6567
RPS29 6566
EIF3L 6537
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
EIF4B 5889
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
EIF3F 5549
EIF3E 5427
RPS21 5369
RPS16 5037
EIF3D 4876
EIF4G1 4736
RPS20 4668
RPS14 4569
EIF4A1 4003
RPS27L 3593
EIF3M 2905
EIF3J 2286
EIF4A2 2172
EIF3K 2031
RPS4Y1 1834
EIF3B 1081
EIF4E 687
EIF5 366
EIF2S3 281
EIF1AX -2134
RPS26 -3603


Josephin domain DUBs

Josephin domain DUBs
614
set Josephin domain DUBs
setSize 10
pANOVA 0.000934
s.dist 0.604
p.adjustANOVA 0.00588



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD23A 8155
UBB 8115
JOSD1 7717
UBA52 7629
UBC 7555
VCP 6975
RAD23B 6333
RPS27A 5715
JOSD2 2327
ATXN3 -7688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD23A 8155
UBB 8115
JOSD1 7717
UBA52 7629
UBC 7555
VCP 6975
RAD23B 6333
RPS27A 5715
JOSD2 2327
ATXN3 -7688


Selenoamino acid metabolism

Selenoamino acid metabolism
1137
set Selenoamino acid metabolism
setSize 113
pANOVA 1.56e-28
s.dist 0.603
p.adjustANOVA 1.52e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
NNMT 8444
EPRS1 8330
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
PAPSS2 7698
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NNMT 8444
EPRS1 8330
RPL3 8213
RPLP0 8195
RPS19 7955
RPS3 7856
RPL18 7818
RPL39 7733
PAPSS2 7698
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
KARS1 7371
AHCY 7259
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
SARS1 6962
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
IARS1 6655
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RPS10 6082
INMT 6074
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
DARS1 5879
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
PAPSS1 5559
RPL14 5533
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
TXNRD1 5014
RPL21 4774
RPL38 4758
CBS 4715
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
PSTK 4376
AIMP2 3773
RPL36A 3707
RPS27L 3593
CTH 2947
EEFSEC 2815
EEF1E1 2660
RARS1 2511
GSR 2189
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
SEPHS2 1467
AIMP1 -1096
MARS1 -2232
SCLY -2874
QARS1 -3397
RPS26 -3603
LARS1 -4201
SEPSECS -5068
SECISBP2 -6240
HNMT -6411


Glycogen synthesis

Glycogen synthesis
492
set Glycogen synthesis
setSize 12
pANOVA 0.000483
s.dist 0.582
p.adjustANOVA 0.00327



Top enriched genes

Top 20 genes
GeneID Gene Rank
PGM1 8325
UBB 8115
PPP1R3C 7781
UBA52 7629
UBC 7555
GBE1 7104
RPS27A 5715
UGP2 4965
NHLRC1 3783
GYG1 1970
GYS1 -65
EPM2A -1707

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PGM1 8325
UBB 8115
PPP1R3C 7781
UBA52 7629
UBC 7555
GBE1 7104
RPS27A 5715
UGP2 4965
NHLRC1 3783
GYG1 1970
GYS1 -65
EPM2A -1707


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
781
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 113
pANOVA 4.79e-25
s.dist 0.562
p.adjustANOVA 3.19e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RBM8A 7891
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RBM8A 7891
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF4A3 7020
RPL13 7009
RNPS1 6994
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
PPP2CA 6300
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
GSPT1 5769
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ETF1 5555
RPL14 5533
RPS21 5369
PPP2R1A 5252
RPLP2 5242
RPL26 5239
SMG8 5235
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
NCBP2 4271
RPL36A 3707
RPS27L 3593
CASC3 2433
PABPC1 2170
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
MAGOH 1007
UPF1 792
PNRC2 710
PPP2R2A 606
GSPT2 170
DCP1A 82
MAGOHB -83
SMG6 -255
UPF2 -283
NCBP1 -364
SMG5 -3275
RPS26 -3603
SMG9 -4480
SMG7 -5415
UPF3B -5740
SMG1 -6130
UPF3A -6972


Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
783
set Nonsense-Mediated Decay (NMD)
setSize 113
pANOVA 4.79e-25
s.dist 0.562
p.adjustANOVA 3.19e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RBM8A 7891
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
RPS19 7955
RBM8A 7891
RPS3 7856
RPL18 7818
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF4A3 7020
RPL13 7009
RNPS1 6994
RPL15 6959
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
PPP2CA 6300
RPL34 6202
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
GSPT1 5769
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ETF1 5555
RPL14 5533
RPS21 5369
PPP2R1A 5252
RPLP2 5242
RPL26 5239
SMG8 5235
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
EIF4G1 4736
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
NCBP2 4271
RPL36A 3707
RPS27L 3593
CASC3 2433
PABPC1 2170
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
MAGOH 1007
UPF1 792
PNRC2 710
PPP2R2A 606
GSPT2 170
DCP1A 82
MAGOHB -83
SMG6 -255
UPF2 -283
NCBP1 -364
SMG5 -3275
RPS26 -3603
SMG9 -4480
SMG7 -5415
UPF3B -5740
SMG1 -6130
UPF3A -6972


TP53 Regulates Transcription of Death Receptors and Ligands

TP53 Regulates Transcription of Death Receptors and Ligands
1302
set TP53 Regulates Transcription of Death Receptors and Ligands
setSize 10
pANOVA 0.00252
s.dist 0.552
p.adjustANOVA 0.014



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFRSF10D 8519
TNFRSF10C 8404
IGFBP3 7172
TP53 6280
TP53BP2 5673
PPP1R13B 4190
FAS 3337
TMEM219 2644
TNFRSF10B 1340
TNFRSF10A 950

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFRSF10D 8519
TNFRSF10C 8404
IGFBP3 7172
TP53 6280
TP53BP2 5673
PPP1R13B 4190
FAS 3337
TMEM219 2644
TNFRSF10B 1340
TNFRSF10A 950


Transport of connexons to the plasma membrane

Transport of connexons to the plasma membrane
1387
set Transport of connexons to the plasma membrane
setSize 13
pANOVA 0.000692
s.dist 0.543
p.adjustANOVA 0.00452



Top enriched genes

Top 20 genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TUBA1C 7408
GJA1 6327
TUBA1B 6282
TUBB4B 5985
TUBAL3 5741
TUBB2B 4999
TUBA1A 3673
TUBB6 3486
TUBA8 2868
TUBB3 2464
GJB2 -3751

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TUBB2A 8415
TUBA4A 8266
TUBA1C 7408
GJA1 6327
TUBA1B 6282
TUBB4B 5985
TUBAL3 5741
TUBB2B 4999
TUBA1A 3673
TUBB6 3486
TUBA8 2868
TUBB3 2464
GJB2 -3751


SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
1098
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 1.07e-10
s.dist 0.533
p.adjustANOVA 3.48e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS19 7955
RPS3 7856
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
RPS11 7228
RPS2 7195
FAU 7160
RPS15 7091
GEMIN5 7041
SNRPD2 6849
RPS18 6831
RPS28 6826
SNRPB 6796
RPS13 6748
RPS12 6739
RPS29 6566
RPS17 6407
RPS10 6082

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS19 7955
RPS3 7856
RPSA 7653
RPS5 7459
RPS6 7412
RPS8 7411
RPS11 7228
RPS2 7195
FAU 7160
RPS15 7091
GEMIN5 7041
SNRPD2 6849
RPS18 6831
RPS28 6826
SNRPB 6796
RPS13 6748
RPS12 6739
RPS29 6566
RPS17 6407
RPS10 6082
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPS27 5857
RPS24 5845
RPS4X 5817
RPS27A 5715
RPS21 5369
SNRPD1 5090
RPS16 5037
RPS20 4668
RPS14 4569
SMN1 4232
RPS27L 3593
GEMIN8 3305
SNRPE 3280
SNRPD3 2994
SNRPG 2011
RPS4Y1 1834
SNRPF 1507
GEMIN6 164
GEMIN2 -945
DDX20 -3434
RPS26 -3603
GEMIN4 -3870
GEMIN7 -6480


Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
1051
set Regulation of expression of SLITs and ROBOs
setSize 162
pANOVA 4.6e-29
s.dist 0.509
p.adjustANOVA 5.19e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
UBB 8115
PSMB5 8014
PSMD8 7975
RPS19 7955
RBM8A 7891
ELOC 7884
RPS3 7856
RPL18 7818
RPL39 7733
PSMC3 7701
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
PSMF1 7577
UBC 7555

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 8213
RPLP0 8195
UBB 8115
PSMB5 8014
PSMD8 7975
RPS19 7955
RBM8A 7891
ELOC 7884
RPS3 7856
RPL18 7818
RPL39 7733
PSMC3 7701
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
PSMF1 7577
UBC 7555
RPL8 7546
PSMB4 7524
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
PSMB7 7370
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
EIF4A3 7020
RPL13 7009
RNPS1 6994
RPL15 6959
PSMD10 6932
RPL27A 6925
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
PSMB6 6641
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
PSMD14 6413
RPS17 6407
PSMD9 6357
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
PSMD1 6241
ELOB 6230
RPL34 6202
RPS10 6082
PSMA5 6069
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
GSPT1 5769
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ETF1 5555
RPL14 5533
PSMC4 5408
PSMA7 5388
PSMD4 5382
RPS21 5369
SEM1 5303
PSMD5 5248
RPLP2 5242
RPL26 5239
PSMD13 5202
RPL35A 5123
RPL27 5077
RPS16 5037
PSMA2 4818
PSMC1 4813
RPL21 4774
RPL38 4758
EIF4G1 4736
PSMD3 4701
RPL35 4688
RPS20 4668
RPS14 4569
RPL24 4535
PSMD2 4456
PSMC5 4430
NCBP2 4271
PSMB8 4048
PSMB1 3958
COL4A5 3951
PSMA1 3947
LDB1 3883
PSMD12 3831
RPL36A 3707
PSMA4 3686
RPS27L 3593
PSMB3 3372
PSMB9 3286
PSME3 2733
PSME4 2643
PSME1 2547
PSMD7 2501
CASC3 2433
PABPC1 2170
RPL22L1 2027
RPS4Y1 1834
RPL9 1672
DAG1 1124
MAGOH 1007
PSMB2 382
GSPT2 170
MAGOHB -83
RBX1 -91
PSMD11 -161
ROBO1 -234
UPF2 -283
NCBP1 -364
PSMC2 -702
PSMC6 -1232
CUL2 -1666
PSMD6 -1811
SLIT1 -1896
SLIT2 -2091
PSMA3 -2099
PSMA6 -2513
ROBO2 -2627
PSMB10 -2727
LHX4 -2970
PSME2 -3086
HOXA2 -3107
RPS26 -3603
UPF3B -5740
ROBO3 -5748
USP33 -5940
UPF3A -6972
ZSWIM8 -7463


Downregulation of ERBB2:ERBB3 signaling

Downregulation of ERBB2:ERBB3 signaling
322
set Downregulation of ERBB2:ERBB3 signaling
setSize 13
pANOVA 0.0015
s.dist 0.508
p.adjustANOVA 0.00873



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
NRG2 8057
UBA52 7629
RNF41 7557
UBC 7555
AKT3 6434
NRG1 6015
RPS27A 5715
AKT1 4206
ERBB3 1958
USP8 558
ERBB2 -270
AKT2 -5098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
NRG2 8057
UBA52 7629
RNF41 7557
UBC 7555
AKT3 6434
NRG1 6015
RPS27A 5715
AKT1 4206
ERBB3 1958
USP8 558
ERBB2 -270
AKT2 -5098


Keratan sulfate biosynthesis

Keratan sulfate biosynthesis
617
set Keratan sulfate biosynthesis
setSize 26
pANOVA 9.09e-06
s.dist 0.503
p.adjustANOVA 9.17e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAN 8463
CHST1 8110
CHST6 7899
OMD 7855
LUM 7763
FMOD 7680
ST3GAL2 7591
ST3GAL3 7565
B4GALT5 7203
PRELP 6934
B4GALT4 6913
OGN 6830
B4GALT6 6664
B4GALT2 6330
CHST5 5779
B4GALT1 4710
ST3GAL1 4654
B4GALT3 3792
ST3GAL4 3706
KERA 2893

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN 8463
CHST1 8110
CHST6 7899
OMD 7855
LUM 7763
FMOD 7680
ST3GAL2 7591
ST3GAL3 7565
B4GALT5 7203
PRELP 6934
B4GALT4 6913
OGN 6830
B4GALT6 6664
B4GALT2 6330
CHST5 5779
B4GALT1 4710
ST3GAL1 4654
B4GALT3 3792
ST3GAL4 3706
KERA 2893
SLC35D2 1950
B3GNT2 -1337
B3GNT7 -1967
B4GAT1 -2345
ST3GAL6 -4160
CHST2 -5911


Membrane binding and targetting of GAG proteins

Membrane binding and targetting of GAG proteins
670
set Membrane binding and targetting of GAG proteins
setSize 14
pANOVA 0.00125
s.dist 0.498
p.adjustANOVA 0.00747



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
VPS37B 7734
UBA52 7629
VPS37A 7599
UBC 7555
RPS27A 5715
UBAP1 4820
VPS37D 4542
MVB12A 4044
TSG101 2732
VPS37C 2725
VPS28 61
NMT2 -759
MVB12B -776

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
VPS37B 7734
UBA52 7629
VPS37A 7599
UBC 7555
RPS27A 5715
UBAP1 4820
VPS37D 4542
MVB12A 4044
TSG101 2732
VPS37C 2725
VPS28 61
NMT2 -759
MVB12B -776


Synthesis And Processing Of GAG, GAGPOL Polyproteins

Synthesis And Processing Of GAG, GAGPOL Polyproteins
1259
set Synthesis And Processing Of GAG, GAGPOL Polyproteins
setSize 14
pANOVA 0.00125
s.dist 0.498
p.adjustANOVA 0.00747



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
VPS37B 7734
UBA52 7629
VPS37A 7599
UBC 7555
RPS27A 5715
UBAP1 4820
VPS37D 4542
MVB12A 4044
TSG101 2732
VPS37C 2725
VPS28 61
NMT2 -759
MVB12B -776

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
VPS37B 7734
UBA52 7629
VPS37A 7599
UBC 7555
RPS27A 5715
UBAP1 4820
VPS37D 4542
MVB12A 4044
TSG101 2732
VPS37C 2725
VPS28 61
NMT2 -759
MVB12B -776


E3 ubiquitin ligases ubiquitinate target proteins

E3 ubiquitin ligases ubiquitinate target proteins
336
set E3 ubiquitin ligases ubiquitinate target proteins
setSize 43
pANOVA 1.68e-08
s.dist 0.497
p.adjustANOVA 4.03e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
UBE2D2 8017
UBA52 7629
UBC 7555
LEO1 7512
SELENOS 7504
RNF152 7303
UBE2N 7174
PEX5 7026
DERL1 7024
RNF144A 7012
VCP 6975
BCL10 6778
RAD18 6448
RRAGA 6122
PCNA 5826
RPS27A 5715
UBE2L3 5619
UBE2J2 5443
RNF181 5236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
UBE2D2 8017
UBA52 7629
UBC 7555
LEO1 7512
SELENOS 7504
RNF152 7303
UBE2N 7174
PEX5 7026
DERL1 7024
RNF144A 7012
VCP 6975
BCL10 6778
RAD18 6448
RRAGA 6122
PCNA 5826
RPS27A 5715
UBE2L3 5619
UBE2J2 5443
RNF181 5236
UBE2D3 5172
CDC73 5087
PEX13 4970
UBE2V2 4587
WAC 4567
H2BC12 4348
RNF20 4107
UBE2E1 4101
PAF1 4093
PEX2 3907
PEX14 3616
UBE2A 1908
PRKDC 1492
UBE2B 1348
PEX12 1230
RNF40 1214
RTF1 796
HLTF 628
PEX10 386
UBE2D1 128
SHPRH -681
TMEM129 -1898
CTR9 -2159


Diseases associated with glycosaminoglycan metabolism

Diseases associated with glycosaminoglycan metabolism
304
set Diseases associated with glycosaminoglycan metabolism
setSize 38
pANOVA 3.78e-07
s.dist 0.476
p.adjustANOVA 5.33e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAN 8463
CHSY1 8258
CHST6 7899
BGN 7889
OMD 7855
LUM 7763
PAPSS2 7698
FMOD 7680
GPC3 7664
SDC4 7646
ST3GAL3 7565
CHST3 7378
PRELP 6934
OGN 6830
VCAN 6743
DCN 6593
CSPG4 6533
SLC26A2 6018
EXT2 5603
CHST14 5060

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAN 8463
CHSY1 8258
CHST6 7899
BGN 7889
OMD 7855
LUM 7763
PAPSS2 7698
FMOD 7680
GPC3 7664
SDC4 7646
ST3GAL3 7565
CHST3 7378
PRELP 6934
OGN 6830
VCAN 6743
DCN 6593
CSPG4 6533
SLC26A2 6018
EXT2 5603
CHST14 5060
SDC1 4879
GPC4 4716
B4GALT1 4710
HEXB 4427
GPC1 3402
B3GALT6 3089
KERA 2893
HSPG2 1665
B4GALT7 1515
GPC2 1096
B3GAT3 998
GPC6 889
AGRN 119
SDC3 -509
HEXA -2615
EXT1 -3708
SDC2 -5470
GPC5 -5667


Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis
189
set Chondroitin sulfate biosynthesis
setSize 16
pANOVA 0.00104
s.dist 0.474
p.adjustANOVA 0.00637



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHSY3 8402
CHSY1 8258
BGN 7889
CHST3 7378
CHPF 6806
VCAN 6743
DCN 6593
CSPG4 6533
CSGALNACT2 6404
CSGALNACT1 5386
CHST11 4243
CHST7 2503
CHPF2 116
CHST15 -2561
CHST12 -2644
CHST13 -4730

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHSY3 8402
CHSY1 8258
BGN 7889
CHST3 7378
CHPF 6806
VCAN 6743
DCN 6593
CSPG4 6533
CSGALNACT2 6404
CSGALNACT1 5386
CHST11 4243
CHST7 2503
CHPF2 116
CHST15 -2561
CHST12 -2644
CHST13 -4730


Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D
1402
set Ubiquitin-dependent degradation of Cyclin D
setSize 50
pANOVA 1.11e-08
s.dist 0.467
p.adjustANOVA 2.86e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
PSMB5 8014
CCND1 7976
PSMD8 7975
PSMC3 7701
UBA52 7629
PSMF1 7577
UBC 7555
PSMB4 7524
PSMB7 7370
PSMD10 6932
PSMB6 6641
PSMD14 6413
PSMD9 6357
PSMD1 6241
PSMA5 6069
RPS27A 5715
PSMC4 5408
PSMA7 5388
PSMD4 5382

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
PSMB5 8014
CCND1 7976
PSMD8 7975
PSMC3 7701
UBA52 7629
PSMF1 7577
UBC 7555
PSMB4 7524
PSMB7 7370
PSMD10 6932
PSMB6 6641
PSMD14 6413
PSMD9 6357
PSMD1 6241
PSMA5 6069
RPS27A 5715
PSMC4 5408
PSMA7 5388
PSMD4 5382
SEM1 5303
PSMD5 5248
PSMD13 5202
PSMA2 4818
PSMC1 4813
PSMD3 4701
PSMD2 4456
PSMC5 4430
CDK4 4259
PSMB8 4048
PSMB1 3958
PSMA1 3947
PSMD12 3831
PSMA4 3686
GSK3B 3440
PSMB3 3372
PSMB9 3286
PSME3 2733
PSME4 2643
PSME1 2547
PSMD7 2501
PSMB2 382
PSMD11 -161
PSMC2 -702
PSMC6 -1232
PSMD6 -1811
PSMA3 -2099
PSMA6 -2513
PSMB10 -2727
PSME2 -3086


Pexophagy

Pexophagy
856
set Pexophagy
setSize 11
pANOVA 0.00734
s.dist 0.467
p.adjustANOVA 0.0361



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
UBA52 7629
UBC 7555
PEX5 7026
EPAS1 6770
RPS27A 5715
NBR1 5401
MAP1LC3B 2819
USP30 240
SQSTM1 -432
ATM -5149

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
UBA52 7629
UBC 7555
PEX5 7026
EPAS1 6770
RPS27A 5715
NBR1 5401
MAP1LC3B 2819
USP30 240
SQSTM1 -432
ATM -5149


ABC transporters in lipid homeostasis

ABC transporters in lipid homeostasis
3
set ABC transporters in lipid homeostasis
setSize 12
pANOVA 0.00518
s.dist -0.466
p.adjustANOVA 0.0272



Top enriched genes

Top 20 genes
GeneID Gene Rank
ABCA5 -7727
ABCA7 -7587
ABCA9 -6982
ABCG1 -6971
ABCD1 -5219
ABCA10 -5205
ABCA3 -3280
ABCA6 -2941
ABCA2 -2022
ABCD3 -1505
PEX19 2002
PEX3 5359

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ABCA5 -7727
ABCA7 -7587
ABCA9 -6982
ABCG1 -6971
ABCD1 -5219
ABCA10 -5205
ABCA3 -3280
ABCA6 -2941
ABCA2 -2022
ABCD3 -1505
PEX19 2002
PEX3 5359


Assembly Of The HIV Virion

Assembly Of The HIV Virion
89
set Assembly Of The HIV Virion
setSize 16
pANOVA 0.00128
s.dist 0.465
p.adjustANOVA 0.00762



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
FURIN 7913
VPS37B 7734
UBA52 7629
VPS37A 7599
UBC 7555
RPS27A 5715
UBAP1 4820
VPS37D 4542
MVB12A 4044
TSG101 2732
VPS37C 2725
VPS28 61
NMT2 -759
MVB12B -776
PPIA -3451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
FURIN 7913
VPS37B 7734
UBA52 7629
VPS37A 7599
UBC 7555
RPS27A 5715
UBAP1 4820
VPS37D 4542
MVB12A 4044
TSG101 2732
VPS37C 2725
VPS28 61
NMT2 -759
MVB12B -776
PPIA -3451


YAP1- and WWTR1 (TAZ)-stimulated gene expression

YAP1- and WWTR1 (TAZ)-stimulated gene expression
1429
set YAP1- and WWTR1 (TAZ)-stimulated gene expression
setSize 11
pANOVA 0.00788
s.dist 0.463
p.adjustANOVA 0.0382



Top enriched genes

Top 20 genes
GeneID Gene Rank
WWTR1 8377
TEAD4 7887
TEAD3 7805
TEAD2 6435
YAP1 5253
RUNX2 3669
HIPK1 3433
TBX5 2969
TEAD1 1254
HIPK2 1055
KAT2B -2826

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WWTR1 8377
TEAD4 7887
TEAD3 7805
TEAD2 6435
YAP1 5253
RUNX2 3669
HIPK1 3433
TBX5 2969
TEAD1 1254
HIPK2 1055
KAT2B -2826


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
734
set NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
setSize 12
pANOVA 0.00633
s.dist -0.455
p.adjustANOVA 0.0315



Top enriched genes

Top 20 genes
GeneID Gene Rank
IKBKB -7336
MAVS -6622
TRIM25 -6584
CASP8 -6383
CASP10 -4604
IKBKG -4559
RNF135 -4329
IFIH1 -3538
RIPK1 -1585
TRIM4 -988
CHUK -574
FADD 6108

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IKBKB -7336
MAVS -6622
TRIM25 -6584
CASP8 -6383
CASP10 -4604
IKBKG -4559
RNF135 -4329
IFIH1 -3538
RIPK1 -1585
TRIM4 -988
CHUK -574
FADD 6108


Cellular response to starvation

Cellular response to starvation
180
set Cellular response to starvation
setSize 148
pANOVA 2.05e-21
s.dist 0.452
p.adjustANOVA 1.11e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATF3 8509
RPL3 8213
RPLP0 8195
ATP6V0D2 8190
EIF2S2 8075
RPS19 7955
ATF4 7924
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATF3 8509
RPL3 8213
RPLP0 8195
ATP6V0D2 8190
EIF2S2 8075
RPS19 7955
ATF4 7924
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
RPL36 7508
RPL5 7478
RPS5 7459
RPS6 7412
RPS8 7411
LAMTOR5 7398
LAMTOR1 7315
ATP6V1H 7289
RPL10A 7231
RPS11 7228
SEC13 7222
RPS2 7195
FAU 7160
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
RPL29 7044
RPL13 7009
RPL15 6959
RPL27A 6925
ATP6V0C 6914
RPL6 6845
RPS18 6831
RPS28 6826
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
RPL28 6643
CEBPB 6582
RPS29 6566
RPL32 6545
RPL11 6445
RPL12 6436
RPS17 6407
ATP6V1D 6384
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
RPL34 6202
RRAGA 6122
RPS10 6082
FNIP2 6067
RPS15A 6064
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
RPL7 5858
RPS27 5857
RPS24 5845
SH3BP4 5819
RPS4X 5817
RPS27A 5715
RPL30 5661
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ATP6V1E1 5545
RPL14 5533
ATP6V1G1 5476
LAMTOR2 5422
RPS21 5369
RPLP2 5242
RPL26 5239
RPL35A 5123
RPL27 5077
RPS16 5037
RPL21 4774
RPL38 4758
BMT2 4729
RPL35 4688
RHEB 4686
RPS20 4668
RPS14 4569
RPL24 4535
ATP6V1F 4187
RPL36A 3707
RPS27L 3593
LAMTOR4 3299
ATP6V1E2 3296
LAMTOR3 3243
ATP6V0E1 2895
CEBPG 2356
ATP6V1B2 2323
ATP6V1C2 2253
RPL22L1 2027
RPS4Y1 1834
MIOS 1789
RPTOR 1676
RPL9 1672
ATP6V1A 1157
RRAGB 1040
ATP6V1C1 997
IMPACT 597
MLST8 414
SESN1 332
EIF2S3 281
RRAGD -11
SEH1L -225
ATP6V0B -278
DEPDC5 -349
TRIB3 -1153
ATP6V0D1 -1220
EIF2AK4 -1649
NPRL3 -2199
ATF2 -2809
ASNS -2937
SESN2 -3406
ATP6V0E2 -3595
RPS26 -3603
MTOR -3642
RRAGC -3773
FNIP1 -3789
ITFG2 -4266
DDIT3 -5113
SZT2 -5363
TCIRG1 -5371
WDR24 -5420
GCN1 -5596
SLC38A9 -5791
WDR59 -6064
NPRL2 -6403
FLCN -6490
KPTN -6890


Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation
1048
set Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize 48
pANOVA 5.92e-08
s.dist 0.452
p.adjustANOVA 1.22e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
UBB 8115
PSMB5 8014
PSMD8 7975
PSMC3 7701
UBA52 7629
PSMF1 7577
UBC 7555
PSMB4 7524
PSMB7 7370
PSMD10 6932
PSMB6 6641
PSMD14 6413
PSMD9 6357
PSMD1 6241
PSMA5 6069
RPS27A 5715
PSMC4 5408
PSMA7 5388
PSMD4 5382
SEM1 5303

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UBB 8115
PSMB5 8014
PSMD8 7975
PSMC3 7701
UBA52 7629
PSMF1 7577
UBC 7555
PSMB4 7524
PSMB7 7370
PSMD10 6932
PSMB6 6641
PSMD14 6413
PSMD9 6357
PSMD1 6241
PSMA5 6069
RPS27A 5715
PSMC4 5408
PSMA7 5388
PSMD4 5382
SEM1 5303
PSMD5 5248
PSMD13 5202
PSMA2 4818
PSMC1 4813
PSMD3 4701
PSMD2 4456
PSMC5 4430
PSMB8 4048
PSMB1 3958
PSMA1 3947
PSMD12 3831
PSMA4 3686
PSMB3 3372
PSMB9 3286
PSME3 2733
PSME4 2643
PSME1 2547
PSMD7 2501
PAK2 1643
PSMB2 382
PSMD11 -161
PSMC2 -702
PSMC6 -1232
PSMD6 -1811
PSMA3 -2099
PSMA6 -2513
PSMB10 -2727
PSME2 -3086


The role of GTSE1 in G2/M progression after G2 checkpoint

The role of GTSE1 in G2/M progression after G2 checkpoint
1329
set The role of GTSE1 in G2/M progression after G2 checkpoint
setSize 69
pANOVA 8.45e-11
s.dist 0.452
p.adjustANOVA 2.81e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDKN1A 8465
TUBB2A 8415
TUBA4A 8266
UBB 8115
PSMB5 8014
PSMD8 7975
PSMC3 7701
UBA52 7629
PSMF1 7577
UBC 7555
PSMB4 7524
TUBA1C 7408
PSMB7 7370
MAPRE1 7099
HSP90AB1 7067
PSMD10 6932
PSMB6 6641
PSMD14 6413
PSMD9 6357
TUBA1B 6282

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDKN1A 8465
TUBB2A 8415
TUBA4A 8266
UBB 8115
PSMB5 8014
PSMD8 7975
PSMC3 7701
UBA52 7629
PSMF1 7577
UBC 7555
PSMB4 7524
TUBA1C 7408
PSMB7 7370
MAPRE1 7099
HSP90AB1 7067
PSMD10 6932
PSMB6 6641
PSMD14 6413
PSMD9 6357
TUBA1B 6282
TP53 6280
HSP90AA1 6254
PSMD1 6241
PSMA5 6069
TUBB4B 5985
TUBAL3 5741
RPS27A 5715
PSMC4 5408
PSMA7 5388
PSMD4 5382
SEM1 5303
PSMD5 5248
PSMD13 5202
TUBB2B 4999
PSMA2 4818
PSMC1 4813
PSMD3 4701
PSMD2 4456
PSMC5 4430
PSMB8 4048
PSMB1 3958
PSMA1 3947
CCNB2 3944
PSMD12 3831
PSMA4 3686
TUBA1A 3673
TUBB6 3486
PSMB3 3372
PSMB9 3286
TUBA8 2868
PSME3 2733
PSME4 2643
PSME1 2547
PSMD7 2501
TUBB3 2464
FKBPL 1536
PSMB2 382
PSMD11 -161
PSMC2 -702
PSMC6 -1232
PSMD6 -1811
PSMA3 -2099
PSMA6 -2513
PSMB10 -2727
CCNB1 -2910
GTSE1 -2915
PSME2 -3086
CDK1 -3637
PLK1 -5099


HSF1 activation

HSF1 activation
518
set HSF1 activation
setSize 25
pANOVA 0.000104
s.dist 0.449
p.adjustANOVA 0.000819



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSPA1B 8461
DNAJB1 8376
HSPA1A 8314
UBB 8115
HSP90AB1 7067
VCP 6975
HSPH1 6800
YWHAE 6747
PTGES3 6500
EEF1A1 6422
RPA1 6273
HSP90AA1 6254
HSF1 6136
FKBP4 6094
RPA3 5671
HSPA1L 5508
SERPINH1 3620
MRPL18 2706
DNAJB6 751
RPA2 -5

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSPA1B 8461
DNAJB1 8376
HSPA1A 8314
UBB 8115
HSP90AB1 7067
VCP 6975
HSPH1 6800
YWHAE 6747
PTGES3 6500
EEF1A1 6422
RPA1 6273
HSP90AA1 6254
HSF1 6136
FKBP4 6094
RPA3 5671
HSPA1L 5508
SERPINH1 3620
MRPL18 2706
DNAJB6 751
RPA2 -5
HSBP1 -656
DEDD2 -864
HSPA6 -2762
TNFRSF21 -5590
HDAC6 -6909


Translation

Translation
1368
set Translation
setSize 290
pANOVA 2.82e-39
s.dist 0.447
p.adjustANOVA 4.13e-36



Top enriched genes

Top 20 genes
GeneID Gene Rank
SSR4 8445
EPRS1 8330
RPL3 8213
RPLP0 8195
MRPL4 8139
SSR2 8090
EIF2S2 8075
RPS19 7955
MRPL17 7917
MRPL42 7902
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
MRPL12 7727
RPSA 7653
UBA52 7629
RPL4 7626

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SSR4 8445
EPRS1 8330
RPL3 8213
RPLP0 8195
MRPL4 8139
SSR2 8090
EIF2S2 8075
RPS19 7955
MRPL17 7917
MRPL42 7902
EIF3I 7883
EIF4EBP1 7864
RPS3 7856
RPL18 7818
EIF2S1 7768
RPL39 7733
MRPL12 7727
RPSA 7653
UBA52 7629
RPL4 7626
RPL19 7605
RPL10 7586
RPL18A 7585
RPL8 7546
EEF1B2 7515
RPL36 7508
SRP68 7501
RPL5 7478
SRPRA 7477
EEF2 7470
RPS5 7459
MRPS24 7419
RPS6 7412
RPS8 7411
EEF1G 7385
MRPL47 7372
KARS1 7371
EIF2B2 7334
EIF3H 7284
MRPL24 7262
SRP54 7238
RPL10A 7231
RPS11 7228
RPS2 7195
FAU 7160
TARS1 7150
EIF3G 7137
RPL41 7136
RPL17 7127
RPS15 7091
RPL37 7088
MRPL11 7085
RPL29 7044
MRPS33 7016
EIF3A 7011
RPL13 7009
EEF1D 6985
YARS1 6970
SARS1 6962
RPL15 6959
EIF4H 6951
EEF1A1P5 6931
RPL27A 6925
AURKAIP1 6902
RPN1 6897
NARS2 6866
RPL6 6845
RPS18 6831
RPS28 6826
MRPL51 6816
CHCHD1 6771
RPL37A 6758
RPL7A 6750
RPS13 6748
RPS12 6739
MRPL2 6712
MRPS15 6674
MRPL40 6663
IARS1 6655
RPL28 6643
SSR3 6579
EIF3C 6567
RPS29 6566
RPL32 6545
EIF3L 6537
MRPS22 6535
DDOST 6522
RPL11 6445
RPL12 6436
EEF1A1 6422
RPS17 6407
RPL22 6352
RPL13A 6349
RPL39L 6344
RPL23 6332
RPLP1 6331
GADD45GIP1 6309
SEC11C 6265
RPL34 6202
RPS10 6082
SEC61B 6081
RPS15A 6064
MRPL16 6029
RPS25 6009
RPS9 5958
RPS3A 5952
RPS7 5915
RPS23 5904
SSR1 5894
EIF4B 5889
DARS1 5879
RPL7 5858
RPS27 5857
RPS24 5845
RPS4X 5817
MRPL50 5789
GSPT1 5769
MRPL49 5719
RPS27A 5715
AARS1 5686
RPL30 5661
GARS1 5647
RPL31 5636
RPL36AL 5631
RPL26L1 5604
RPL23A 5596
ETF1 5555
MRPL14 5551
TUFM 5550
EIF3F 5549
RPL14 5533
MRPL28 5516
MRPL53 5474
MRPL55 5444
EIF3E 5427
MRPS23 5397
RPS21 5369
RPLP2 5242
RPL26 5239
MRPL52 5237
MRPL54 5191
MRPS16 5150
RPL35A 5123
MRPS17 5092
RPL27 5077
RPS16 5037
MRPL46 4997
SEC11A 4959
EIF3D 4876
MRPS12 4822
RPL21 4774
RPL38 4758
EIF4G1 4736
MRPS7 4720
RPL35 4688
SRPRB 4673
RPS20 4668
MRPL41 4605
RPS14 4569
RPL24 4535
EIF2B3 4528
MRPL13 4512
PPA1 4507
MRPS30 4484
MRPL34 4466
MRPS18C 4431
MRPS21 4309
MRPL37 4291
TRMT112 4285
MRPL36 4258
MRPS2 4253
MRPS10 4250
MRPL22 4224
MTRF1L 4168
CARS1 4126
MRPL38 4116
TSFM 4108
MRPL44 4075
RARS2 4036
EIF4A1 4003
MRPL58 3959
MRPS34 3901
MRPS6 3834
AIMP2 3773
RPL36A 3707
MRPL21 3688
MRPS11 3624
RPS27L 3593
LARS2 3566
MRPS27 3541
FARS2 3536
YARS2 3527
MRPL57 3395
MRPL15 3316
MRPS18A 3295
DAP3 3291
SPCS2 3211
MRPL23 3204
MARS2 3059
RPN2 3032
MRPS26 2957
EIF3M 2905
MRPL18 2706
PPA2 2698
EEF1E1 2660
MRPL48 2629
RARS1 2511
MRPL9 2476
FARSB 2403
TRAM1 2399
HARS1 2371
MRPL39 2351
MRPL20 2305
EIF3J 2286
MRPL33 2281
SRP72 2191
EIF4A2 2172
PABPC1 2170
EIF3K 2031
RPL22L1 2027
MTFMT 1943
RPS4Y1 1834
MRPS31 1698
SPCS3 1674
RPL9 1672
MRPL32 1606
MRPL3 1553
MRPS28 1513
MRPL30 1371
WARS1 1273
MRPS36 1094
EIF3B 1081
SRP14 1061
MRPS14 973
MRPS18B 912
SEC61A1 892
MRPL19 890
EIF4E 687
MRPL45 609
CARS2 603
GFM1 602
SEC61G 572
MRPS9 451
EIF5 366
EIF2S3 281
APEH 278
GSPT2 170
IARS2 51
MRPL43 3
EIF5B -22
MRPL27 -117
EIF2B4 -157
MRPL10 -218
GFM2 -260
SPCS1 -729
SRP19 -842
EARS2 -878
AIMP1 -1096
SRP9 -1159
FARSA -1210
TARS2 -1902
NARS1 -1909
WARS2 -2079
MRPL1 -2088
EIF1AX -2134
MARS1 -2232
MTIF3 -2371
MRPS35 -2621
MRRF -2642
SARS2 -3353
QARS1 -3397
MRPL35 -3433
RPS26 -3603
PARS2 -3634
ERAL1 -3685
EIF2B5 -3891
DARS2 -3956
LARS1 -4201
EIF2B1 -4304
VARS1 -4381
SEC61A2 -5327
MRPS25 -5408
MTIF2 -5535
AARS2 -5611
PTCD3 -5666
OXA1L -6182
MRPS5 -6216
VARS2 -6872
HARS2 -7188
N6AMT1 -7350


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               zlibbioc_1.48.0         cachem_1.0.8           
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.8             
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report