date generated: 2022-05-11

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## 5_8S_rRNA -0.2991328
## 7SK        1.4891703
## A1BG       2.3425345
## A1BG-AS1   0.5536952
## A2M       -1.3733855
## A2M-AS1   -1.2521699
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 2512
num_genes_in_profile 18694
duplicated_genes_present 0
num_profile_genes_in_sets 8649
num_profile_genes_not_in_sets 10045

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
Gene sets metrics
Gene sets metrics
num_genesets 2512
num_genesets_excluded 1069
num_genesets_included 1443

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
Initial triggering of complement 49 7.28e-25 -0.849 1.05e-21
Classical antibody-mediated complement activation 38 1.22e-22 -0.917 8.78e-20
Creation of C4 and C2 activators 42 1.82e-22 -0.869 8.78e-20
Cell Cycle 611 8.73e-22 0.228 3.15e-19
Cell Cycle, Mitotic 495 7.83e-20 0.239 2.26e-17
Complement cascade 72 2.06e-19 -0.614 4.96e-17
Regulation of Complement cascade 66 4.02e-19 -0.636 8.28e-17
Scavenging of heme from plasma 39 2.70e-18 -0.807 4.86e-16
Binding and Uptake of Ligands by Scavenger Receptors 66 1.12e-17 -0.609 1.79e-15
Cell Cycle Checkpoints 252 1.40e-17 0.312 2.02e-15
FCGR activation 45 3.96e-16 -0.701 5.19e-14
M Phase 354 1.43e-14 0.238 1.72e-12
CD22 mediated BCR regulation 36 1.71e-14 -0.738 1.90e-12
Mitotic Prometaphase 184 1.24e-13 0.317 1.28e-11
Resolution of Sister Chromatid Cohesion 104 7.24e-13 0.407 6.96e-11
Role of LAT2/NTAL/LAB on calcium mobilization 42 9.97e-13 -0.636 8.99e-11
Separation of Sister Chromatids 167 1.41e-11 0.303 1.19e-09
Mitotic Spindle Checkpoint 108 1.52e-11 0.376 1.22e-09
Mitotic Anaphase 222 2.06e-11 0.261 1.54e-09
Mitotic Metaphase and Anaphase 223 2.13e-11 0.260 1.54e-09
Anti-inflammatory response favouring Leishmania parasite infection 139 5.24e-11 -0.322 3.44e-09
Leishmania parasite growth and survival 139 5.24e-11 -0.322 3.44e-09
EML4 and NUDC in mitotic spindle formation 95 6.67e-11 0.387 4.18e-09
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 9.23e-11 0.393 5.33e-09
Amplification of signal from the kinetochores 91 9.23e-11 0.393 5.33e-09
Role of phospholipids in phagocytosis 58 1.12e-10 -0.490 6.19e-09
FCGR3A-mediated IL10 synthesis 70 1.62e-10 -0.442 8.67e-09
Kinesins 37 1.07e-09 0.579 5.52e-08
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 60 1.73e-09 -0.449 8.63e-08
FCGR3A-mediated phagocytosis 92 2.18e-09 -0.361 9.83e-08
Leishmania phagocytosis 92 2.18e-09 -0.361 9.83e-08
Parasite infection 92 2.18e-09 -0.361 9.83e-08
RHO GTPases Activate Formins 118 2.74e-09 0.317 1.20e-07
rRNA processing 214 4.56e-09 -0.233 1.94e-07
Regulation of actin dynamics for phagocytic cup formation 94 4.84e-09 -0.349 2.00e-07
FCERI mediated MAPK activation 58 1.70e-08 -0.428 6.68e-07
Leishmania infection 220 1.71e-08 -0.221 6.68e-07
rRNA processing in the nucleus and cytosol 190 2.10e-08 -0.236 7.97e-07
RHO GTPase Effectors 243 3.95e-08 0.205 1.46e-06
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.03e-07 -0.230 3.73e-06
G2/M Checkpoints 133 3.97e-07 0.255 1.40e-05
Mitotic G2-G2/M phases 180 4.58e-07 0.218 1.57e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 621 6.41e-07 0.117 2.15e-05
DNA Replication 138 8.56e-07 0.243 2.81e-05
FCERI mediated Ca+2 mobilization 57 1.05e-06 -0.374 3.36e-05
G2/M Transition 178 1.15e-06 0.211 3.59e-05
Signaling by Rho GTPases 605 1.19e-06 0.116 3.65e-05
Deposition of new CENPA-containing nucleosomes at the centromere 36 1.36e-06 0.465 4.00e-05
Nucleosome assembly 36 1.36e-06 0.465 4.00e-05
Fcgamma receptor (FCGR) dependent phagocytosis 119 1.51e-06 -0.255 4.35e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Initial triggering of complement 49 7.28e-25 -8.49e-01 1.05e-21
Classical antibody-mediated complement activation 38 1.22e-22 -9.17e-01 8.78e-20
Creation of C4 and C2 activators 42 1.82e-22 -8.69e-01 8.78e-20
Cell Cycle 611 8.73e-22 2.28e-01 3.15e-19
Cell Cycle, Mitotic 495 7.83e-20 2.39e-01 2.26e-17
Complement cascade 72 2.06e-19 -6.14e-01 4.96e-17
Regulation of Complement cascade 66 4.02e-19 -6.36e-01 8.28e-17
Scavenging of heme from plasma 39 2.70e-18 -8.07e-01 4.86e-16
Binding and Uptake of Ligands by Scavenger Receptors 66 1.12e-17 -6.09e-01 1.79e-15
Cell Cycle Checkpoints 252 1.40e-17 3.12e-01 2.02e-15
FCGR activation 45 3.96e-16 -7.01e-01 5.19e-14
M Phase 354 1.43e-14 2.38e-01 1.72e-12
CD22 mediated BCR regulation 36 1.71e-14 -7.38e-01 1.90e-12
Mitotic Prometaphase 184 1.24e-13 3.17e-01 1.28e-11
Resolution of Sister Chromatid Cohesion 104 7.24e-13 4.07e-01 6.96e-11
Role of LAT2/NTAL/LAB on calcium mobilization 42 9.97e-13 -6.36e-01 8.99e-11
Separation of Sister Chromatids 167 1.41e-11 3.03e-01 1.19e-09
Mitotic Spindle Checkpoint 108 1.52e-11 3.76e-01 1.22e-09
Mitotic Anaphase 222 2.06e-11 2.61e-01 1.54e-09
Mitotic Metaphase and Anaphase 223 2.13e-11 2.60e-01 1.54e-09
Anti-inflammatory response favouring Leishmania parasite infection 139 5.24e-11 -3.22e-01 3.44e-09
Leishmania parasite growth and survival 139 5.24e-11 -3.22e-01 3.44e-09
EML4 and NUDC in mitotic spindle formation 95 6.67e-11 3.87e-01 4.18e-09
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 9.23e-11 3.93e-01 5.33e-09
Amplification of signal from the kinetochores 91 9.23e-11 3.93e-01 5.33e-09
Role of phospholipids in phagocytosis 58 1.12e-10 -4.90e-01 6.19e-09
FCGR3A-mediated IL10 synthesis 70 1.62e-10 -4.42e-01 8.67e-09
Kinesins 37 1.07e-09 5.79e-01 5.52e-08
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 60 1.73e-09 -4.49e-01 8.63e-08
FCGR3A-mediated phagocytosis 92 2.18e-09 -3.61e-01 9.83e-08
Leishmania phagocytosis 92 2.18e-09 -3.61e-01 9.83e-08
Parasite infection 92 2.18e-09 -3.61e-01 9.83e-08
RHO GTPases Activate Formins 118 2.74e-09 3.17e-01 1.20e-07
rRNA processing 214 4.56e-09 -2.33e-01 1.94e-07
Regulation of actin dynamics for phagocytic cup formation 94 4.84e-09 -3.49e-01 2.00e-07
FCERI mediated MAPK activation 58 1.70e-08 -4.28e-01 6.68e-07
Leishmania infection 220 1.71e-08 -2.21e-01 6.68e-07
rRNA processing in the nucleus and cytosol 190 2.10e-08 -2.36e-01 7.97e-07
RHO GTPase Effectors 243 3.95e-08 2.05e-01 1.46e-06
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.03e-07 -2.30e-01 3.73e-06
G2/M Checkpoints 133 3.97e-07 2.55e-01 1.40e-05
Mitotic G2-G2/M phases 180 4.58e-07 2.18e-01 1.57e-05
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 621 6.41e-07 1.17e-01 2.15e-05
DNA Replication 138 8.56e-07 2.43e-01 2.81e-05
FCERI mediated Ca+2 mobilization 57 1.05e-06 -3.74e-01 3.36e-05
G2/M Transition 178 1.15e-06 2.11e-01 3.59e-05
Signaling by Rho GTPases 605 1.19e-06 1.16e-01 3.65e-05
Deposition of new CENPA-containing nucleosomes at the centromere 36 1.36e-06 4.65e-01 4.00e-05
Nucleosome assembly 36 1.36e-06 4.65e-01 4.00e-05
Fcgamma receptor (FCGR) dependent phagocytosis 119 1.51e-06 -2.55e-01 4.35e-05
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 93 1.60e-06 -2.88e-01 4.54e-05
Eukaryotic Translation Termination 92 2.52e-06 -2.84e-01 6.99e-05
Mitotic G1 phase and G1/S transition 147 4.22e-06 2.20e-01 1.15e-04
Viral mRNA Translation 88 4.39e-06 -2.83e-01 1.16e-04
Eukaryotic Translation Elongation 93 4.42e-06 -2.75e-01 1.16e-04
Formation of a pool of free 40S subunits 100 4.80e-06 -2.65e-01 1.22e-04
Factors involved in megakaryocyte development and platelet production 110 4.80e-06 2.52e-01 1.22e-04
Peptide chain elongation 88 5.04e-06 -2.81e-01 1.25e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 5.12e-06 -2.72e-01 1.25e-04
Selenocysteine synthesis 92 7.48e-06 -2.70e-01 1.80e-04
G1/S Transition 129 9.92e-06 2.25e-01 2.35e-04
Cellular Senescence 139 1.19e-05 2.15e-01 2.76e-04
Cilium Assembly 179 1.66e-05 1.87e-01 3.80e-04
G1/S-Specific Transcription 28 1.87e-05 4.67e-01 4.21e-04
SRP-dependent cotranslational protein targeting to membrane 111 2.40e-05 -2.32e-01 5.32e-04
Transcriptional Regulation by TP53 348 3.38e-05 1.30e-01 7.39e-04
GTP hydrolysis and joining of the 60S ribosomal subunit 111 3.80e-05 -2.26e-01 8.17e-04
Neutrophil degranulation 446 3.88e-05 1.14e-01 8.24e-04
DNA Replication Pre-Initiation 96 3.94e-05 2.43e-01 8.24e-04
S Phase 159 4.14e-05 1.88e-01 8.53e-04
Assembly of the pre-replicative complex 80 4.30e-05 2.65e-01 8.74e-04
Infectious disease 752 4.43e-05 -8.77e-02 8.88e-04
G alpha (s) signalling events 86 4.61e-05 -2.54e-01 9.12e-04
Post-translational protein phosphorylation 83 5.08e-05 -2.57e-01 9.90e-04
Activation of ATR in response to replication stress 36 6.44e-05 3.85e-01 1.24e-03
Golgi-to-ER retrograde transport 109 7.34e-05 2.20e-01 1.39e-03
Influenza Viral RNA Transcription and Replication 135 7.45e-05 -1.98e-01 1.40e-03
L13a-mediated translational silencing of Ceruloplasmin expression 110 7.86e-05 -2.18e-01 1.45e-03
PRC2 methylates histones and DNA 24 1.04e-04 4.58e-01 1.90e-03
Intra-Golgi and retrograde Golgi-to-ER traffic 176 1.10e-04 1.69e-01 1.96e-03
Cyclin A/B1/B2 associated events during G2/M transition 23 1.10e-04 4.66e-01 1.96e-03
Cap-dependent Translation Initiation 118 1.19e-04 -2.05e-01 2.07e-03
Eukaryotic Translation Initiation 118 1.19e-04 -2.05e-01 2.07e-03
Surfactant metabolism 21 1.50e-04 -4.78e-01 2.57e-03
Chromosome Maintenance 99 1.54e-04 2.20e-01 2.62e-03
Phase I - Functionalization of compounds 70 1.64e-04 -2.61e-01 2.76e-03
G0 and Early G1 26 1.73e-04 4.25e-01 2.87e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.82e-04 -2.03e-01 2.96e-03
Nonsense-Mediated Decay (NMD) 114 1.82e-04 -2.03e-01 2.96e-03
Oxidative Stress Induced Senescence 74 1.89e-04 2.51e-01 3.04e-03
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 47 2.15e-04 3.12e-01 3.42e-03
Cell surface interactions at the vascular wall 141 2.26e-04 -1.80e-01 3.54e-03
Transcriptional regulation by RUNX1 176 2.51e-04 1.60e-01 3.88e-03
Homology Directed Repair 104 2.53e-04 2.08e-01 3.88e-03
COPI-dependent Golgi-to-ER retrograde traffic 76 2.57e-04 2.43e-01 3.91e-03
Plasma lipoprotein remodeling 22 3.05e-04 -4.45e-01 4.59e-03
Insulin receptor recycling 23 3.72e-04 4.29e-01 5.54e-03
Plasma lipoprotein assembly, remodeling, and clearance 56 3.94e-04 -2.74e-01 5.80e-03
APC/C-mediated degradation of cell cycle proteins 85 4.03e-04 2.22e-01 5.81e-03
Regulation of mitotic cell cycle 85 4.03e-04 2.22e-01 5.81e-03
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 98 4.12e-04 2.07e-01 5.89e-03
Condensation of Prophase Chromosomes 24 4.19e-04 4.16e-01 5.93e-03
Deubiquitination 235 4.87e-04 1.32e-01 6.82e-03
Switching of origins to a post-replicative state 88 4.97e-04 2.15e-01 6.89e-03
Meiotic recombination 32 5.16e-04 3.55e-01 7.03e-03
Influenza Infection 154 5.17e-04 -1.62e-01 7.03e-03
Meiosis 59 5.21e-04 2.61e-01 7.03e-03
Metabolism of RNA 676 5.29e-04 -7.84e-02 7.06e-03
Selenoamino acid metabolism 115 6.20e-04 -1.85e-01 8.18e-03
Defective pyroptosis 24 6.23e-04 4.03e-01 8.18e-03
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 132 6.41e-04 -1.72e-01 8.34e-03
DNA methylation 15 6.50e-04 5.08e-01 8.38e-03
Organelle biogenesis and maintenance 271 6.56e-04 1.20e-01 8.38e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 34 6.93e-04 3.36e-01 8.77e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 74 7.42e-04 2.27e-01 9.24e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 7.43e-04 -1.95e-01 9.24e-03
Amine ligand-binding receptors 15 7.69e-04 -5.02e-01 9.48e-03
Polo-like kinase mediated events 15 7.84e-04 5.01e-01 9.59e-03
G2/M DNA damage checkpoint 62 8.50e-04 2.45e-01 1.03e-02
Processing of DNA double-strand break ends 65 8.68e-04 2.39e-01 1.04e-02
Interconversion of nucleotide di- and triphosphates 29 8.70e-04 3.57e-01 1.04e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 73 8.86e-04 2.25e-01 1.05e-02
Neuronal System 274 9.09e-04 -1.17e-01 1.07e-02
Synthesis of DNA 117 1.16e-03 1.74e-01 1.34e-02
Heparan sulfate/heparin (HS-GAG) metabolism 44 1.16e-03 -2.83e-01 1.34e-02
TP53 Regulates Transcription of Cell Death Genes 42 1.28e-03 2.87e-01 1.46e-02
RNA Polymerase II Transcription 1215 1.37e-03 5.48e-02 1.56e-02
DNA Double-Strand Break Repair 132 1.42e-03 1.61e-01 1.59e-02
Assembly of the ORC complex at the origin of replication 20 1.43e-03 4.12e-01 1.59e-02
Programmed Cell Death 193 1.50e-03 1.33e-01 1.67e-02
Transferrin endocytosis and recycling 29 1.54e-03 3.40e-01 1.69e-02
ADORA2B mediated anti-inflammatory cytokines production 75 1.69e-03 -2.10e-01 1.85e-02
Regulation of APC/C activators between G1/S and early anaphase 78 1.72e-03 2.05e-01 1.86e-02
Diseases of programmed cell death 51 1.76e-03 2.53e-01 1.90e-02
Resolution of D-Loop Structures 32 1.80e-03 3.19e-01 1.93e-02
Transcriptional Regulation by E2F6 34 1.84e-03 3.09e-01 1.95e-02
Senescence-Associated Secretory Phenotype (SASP) 61 2.01e-03 2.29e-01 2.12e-02
Recruitment of NuMA to mitotic centrosomes 79 2.14e-03 2.00e-01 2.24e-02
Mitotic Prophase 93 2.18e-03 1.84e-01 2.26e-02
Translation 294 2.46e-03 -1.03e-01 2.53e-02
Generic Transcription Pathway 1097 2.49e-03 5.43e-02 2.55e-02
Gene expression (Transcription) 1348 2.55e-03 4.92e-02 2.59e-02
DNA Damage/Telomere Stress Induced Senescence 39 2.61e-03 2.79e-01 2.63e-02
NGF-stimulated transcription 35 2.62e-03 2.94e-01 2.63e-02
Apoptosis 167 2.65e-03 1.35e-01 2.64e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 71 2.72e-03 2.06e-01 2.69e-02
ROS and RNS production in phagocytes 33 2.77e-03 3.01e-01 2.72e-02
Inactivation of APC/C via direct inhibition of the APC/C complex 21 2.81e-03 3.77e-01 2.72e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 2.81e-03 3.77e-01 2.72e-02
MET activates PTK2 signaling 18 3.03e-03 -4.04e-01 2.91e-02
Chromatin modifying enzymes 210 3.16e-03 1.18e-01 3.00e-02
Chromatin organization 210 3.16e-03 1.18e-01 3.00e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 3.19e-03 2.04e-01 3.01e-02
Pre-NOTCH Transcription and Translation 44 3.26e-03 2.56e-01 3.06e-02
AURKA Activation by TPX2 71 3.37e-03 2.01e-01 3.13e-02
Anchoring of the basal body to the plasma membrane 96 3.40e-03 1.73e-01 3.13e-02
VEGFR2 mediated cell proliferation 19 3.42e-03 3.88e-01 3.13e-02
Reproduction 68 3.44e-03 2.05e-01 3.13e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 31 3.44e-03 3.04e-01 3.13e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 3.49e-03 2.81e-01 3.15e-02
Downstream signaling events of B Cell Receptor (BCR) 79 3.52e-03 1.90e-01 3.15e-02
Transcriptional regulation by RUNX2 116 3.65e-03 1.56e-01 3.24e-02
CDC6 association with the ORC:origin complex 11 3.66e-03 5.06e-01 3.24e-02
Keratinization 32 4.02e-03 -2.94e-01 3.54e-02
Collagen degradation 36 4.08e-03 2.77e-01 3.57e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 4.34e-03 3.30e-01 3.77e-02
Disease 1424 4.40e-03 -4.53e-02 3.80e-02
GPCR ligand binding 246 4.53e-03 -1.05e-01 3.89e-02
Ub-specific processing proteases 163 4.87e-03 1.28e-01 4.15e-02
Transcriptional regulation of granulopoiesis 39 4.89e-03 2.60e-01 4.15e-02
Response of EIF2AK1 (HRI) to heme deficiency 15 4.92e-03 4.19e-01 4.15e-02
Activation of the pre-replicative complex 32 5.10e-03 2.86e-01 4.22e-02
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function 23 5.18e-03 3.37e-01 4.22e-02
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function 23 5.18e-03 3.37e-01 4.22e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 23 5.18e-03 3.37e-01 4.22e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 23 5.18e-03 3.37e-01 4.22e-02
Diseases of DNA Double-Strand Break Repair 23 5.18e-03 3.37e-01 4.22e-02
Interferon gamma signaling 84 5.22e-03 -1.76e-01 4.23e-02
A tetrasaccharide linker sequence is required for GAG synthesis 23 5.26e-03 -3.36e-01 4.24e-02
FCERI mediated NF-kB activation 105 5.30e-03 -1.58e-01 4.25e-02
Immune System 1727 5.41e-03 4.06e-02 4.31e-02
CDK-mediated phosphorylation and removal of Cdc6 70 5.61e-03 1.91e-01 4.45e-02
DNA Repair 284 5.75e-03 9.53e-02 4.50e-02
Erythrocytes take up carbon dioxide and release oxygen 10 5.77e-03 5.04e-01 4.50e-02
O2/CO2 exchange in erythrocytes 10 5.77e-03 5.04e-01 4.50e-02
Signaling by Insulin receptor 63 5.95e-03 2.00e-01 4.61e-02
rRNA modification in the nucleus and cytosol 59 6.14e-03 -2.06e-01 4.72e-02
Centrosome maturation 80 6.19e-03 1.77e-01 4.72e-02
Recruitment of mitotic centrosome proteins and complexes 80 6.19e-03 1.77e-01 4.72e-02
Membrane Trafficking 572 6.35e-03 6.69e-02 4.81e-02
Signal Transduction 2098 6.37e-03 3.65e-02 4.81e-02
Nonhomologous End-Joining (NHEJ) 38 6.41e-03 2.56e-01 4.82e-02
Nuclear signaling by ERBB4 29 6.52e-03 -2.92e-01 4.87e-02
Voltage gated Potassium channels 21 6.69e-03 -3.42e-01 4.95e-02
Homologous DNA Pairing and Strand Exchange 41 6.70e-03 2.45e-01 4.95e-02
Elastic fibre formation 38 6.72e-03 -2.54e-01 4.95e-02
Diseases of DNA repair 32 6.94e-03 2.76e-01 5.08e-02
Presynaptic phase of homologous DNA pairing and strand exchange 38 7.02e-03 2.53e-01 5.12e-02
Epigenetic regulation of gene expression 98 7.07e-03 1.57e-01 5.13e-02
Regulation of PLK1 Activity at G2/M Transition 86 7.16e-03 1.68e-01 5.16e-02
Phosphorylation of the APC/C 20 7.21e-03 3.47e-01 5.18e-02
Meiotic synapsis 38 7.35e-03 2.51e-01 5.25e-02
Orc1 removal from chromatin 68 7.43e-03 1.88e-01 5.28e-02
Eicosanoid ligand-binding receptors 14 7.62e-03 -4.12e-01 5.39e-02
Antimicrobial peptides 30 7.74e-03 2.81e-01 5.45e-02
Unwinding of DNA 12 7.90e-03 4.43e-01 5.53e-02
Amino acids regulate mTORC1 51 7.99e-03 2.15e-01 5.55e-02
Diseases of mitotic cell cycle 38 8.00e-03 2.49e-01 5.55e-02
Activation of Matrix Metalloproteinases 25 8.26e-03 3.05e-01 5.70e-02
Regulation of expression of SLITs and ROBOs 164 8.35e-03 -1.19e-01 5.74e-02
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.60e-03 3.79e-01 5.88e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 8.94e-03 1.78e-01 6.08e-02
Potassium Channels 59 9.17e-03 -1.96e-01 6.21e-02
HDR through Homologous Recombination (HRR) 65 9.25e-03 1.87e-01 6.23e-02
Class A/1 (Rhodopsin-like receptors) 176 1.02e-02 -1.12e-01 6.82e-02
APC-Cdc20 mediated degradation of Nek2A 26 1.04e-02 2.90e-01 6.94e-02
Loss of Nlp from mitotic centrosomes 68 1.05e-02 1.79e-01 6.95e-02
Loss of proteins required for interphase microtubule organization from the centrosome 68 1.05e-02 1.79e-01 6.95e-02
Metabolism of nucleotides 85 1.07e-02 1.60e-01 7.03e-02
Syndecan interactions 20 1.10e-02 3.28e-01 7.20e-02
ERBB2 Activates PTK6 Signaling 11 1.10e-02 -4.43e-01 7.20e-02
Condensation of Prometaphase Chromosomes 11 1.20e-02 4.38e-01 7.78e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 76 1.24e-02 1.66e-01 8.03e-02
Cellular hexose transport 15 1.32e-02 3.70e-01 8.50e-02
Initiation of Nuclear Envelope (NE) Reformation 19 1.34e-02 3.28e-01 8.54e-02
Mitotic Telophase/Cytokinesis 13 1.34e-02 3.96e-01 8.54e-02
RA biosynthesis pathway 17 1.34e-02 -3.46e-01 8.54e-02
Nuclear Events (kinase and transcription factor activation) 57 1.37e-02 1.89e-01 8.69e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 17 1.43e-02 -3.43e-01 9.02e-02
HDMs demethylate histones 22 1.44e-02 3.01e-01 9.02e-02
Interleukin-12 signaling 41 1.46e-02 2.20e-01 9.11e-02
Protein-protein interactions at synapses 69 1.51e-02 -1.69e-01 9.37e-02
Pre-NOTCH Expression and Processing 60 1.54e-02 1.81e-01 9.57e-02
CLEC7A (Dectin-1) induces NFAT activation 11 1.61e-02 4.19e-01 9.90e-02
Class I MHC mediated antigen processing & presentation 352 1.62e-02 7.47e-02 9.92e-02
Synthesis of PIPs at the early endosome membrane 16 1.65e-02 3.46e-01 1.01e-01
CLEC7A (Dectin-1) signaling 97 1.70e-02 1.40e-01 1.03e-01
SIRT1 negatively regulates rRNA expression 19 1.72e-02 3.16e-01 1.04e-01
Antigen processing: Ubiquitination & Proteasome degradation 288 1.76e-02 8.14e-02 1.06e-01
Synthesis of PIPs at the late endosome membrane 11 1.78e-02 4.13e-01 1.07e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.80e-02 2.50e-01 1.07e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 16 1.87e-02 3.40e-01 1.11e-01
Intrinsic Pathway for Apoptosis 55 2.01e-02 1.81e-01 1.19e-01
STAT3 nuclear events downstream of ALK signaling 10 2.01e-02 4.25e-01 1.19e-01
Diseases of metabolism 207 2.05e-02 -9.35e-02 1.20e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 2.05e-02 2.73e-01 1.20e-01
Regulated Necrosis 52 2.06e-02 1.86e-01 1.20e-01
Metalloprotease DUBs 20 2.09e-02 2.98e-01 1.21e-01
cGMP effects 14 2.10e-02 -3.56e-01 1.22e-01
APC/C:Cdc20 mediated degradation of Securin 66 2.12e-02 1.64e-01 1.22e-01
Signaling by ROBO receptors 205 2.21e-02 -9.28e-02 1.27e-01
RIPK1-mediated regulated necrosis 28 2.22e-02 2.50e-01 1.27e-01
Regulation of necroptotic cell death 28 2.22e-02 2.50e-01 1.27e-01
Cyclin E associated events during G1/S transition 82 2.27e-02 1.46e-01 1.29e-01
Transcription of E2F targets under negative control by DREAM complex 19 2.28e-02 3.02e-01 1.29e-01
PI3K events in ERBB2 signaling 14 2.30e-02 -3.51e-01 1.30e-01
Cleavage of the damaged pyrimidine 24 2.36e-02 2.67e-01 1.31e-01
Depyrimidination 24 2.36e-02 2.67e-01 1.31e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 24 2.36e-02 2.67e-01 1.31e-01
Defective B4GALT7 causes EDS, progeroid type 17 2.37e-02 -3.17e-01 1.31e-01
Transcriptional regulation of white adipocyte differentiation 83 2.39e-02 -1.43e-01 1.32e-01
Neddylation 218 2.46e-02 8.84e-02 1.35e-01
Constitutive Signaling by Aberrant PI3K in Cancer 59 2.49e-02 -1.69e-01 1.37e-01
Cyclin A:Cdk2-associated events at S phase entry 84 2.52e-02 1.41e-01 1.38e-01
Neurexins and neuroligins 46 2.56e-02 -1.90e-01 1.40e-01
Establishment of Sister Chromatid Cohesion 11 2.69e-02 3.85e-01 1.46e-01
ERBB2 Regulates Cell Motility 13 2.70e-02 -3.54e-01 1.46e-01
TP53 Regulates Transcription of Cell Cycle Genes 44 2.74e-02 1.92e-01 1.47e-01
Regulation of PTEN mRNA translation 12 2.74e-02 3.68e-01 1.47e-01
Signaling by Hippo 20 2.76e-02 2.85e-01 1.47e-01
Assembly of collagen fibrils and other multimeric structures 53 2.77e-02 1.75e-01 1.47e-01
Post-translational protein modification 1224 2.78e-02 3.76e-02 1.47e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 2.81e-02 3.08e-01 1.47e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 2.81e-02 3.08e-01 1.47e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 2.81e-02 4.01e-01 1.47e-01
Interleukin-12 family signaling 49 2.86e-02 1.81e-01 1.50e-01
Ion channel transport 134 2.92e-02 1.09e-01 1.52e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 52 2.94e-02 1.75e-01 1.53e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 3.04e-02 3.61e-01 1.55e-01
MyD88-independent TLR4 cascade 97 3.04e-02 1.27e-01 1.55e-01
TRIF(TICAM1)-mediated TLR4 signaling 97 3.04e-02 1.27e-01 1.55e-01
Scavenging by Class A Receptors 17 3.05e-02 -3.03e-01 1.55e-01
Regulation of RAS by GAPs 65 3.06e-02 1.55e-01 1.55e-01
Diseases of glycosylation 129 3.07e-02 -1.10e-01 1.55e-01
Metabolism of amino acids and derivatives 327 3.07e-02 -6.96e-02 1.55e-01
Iron uptake and transport 56 3.07e-02 1.67e-01 1.55e-01
PTEN Regulation 138 3.10e-02 1.06e-01 1.56e-01
CD28 dependent Vav1 pathway 11 3.12e-02 -3.75e-01 1.57e-01
Cholesterol biosynthesis 24 3.18e-02 2.53e-01 1.59e-01
Estrogen-dependent gene expression 96 3.22e-02 1.27e-01 1.60e-01
Retrograde transport at the Trans-Golgi-Network 49 3.23e-02 1.77e-01 1.60e-01
Defective B3GAT3 causes JDSSDHD 17 3.27e-02 -2.99e-01 1.62e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.29e-02 -1.73e-01 1.62e-01
Transcriptional regulation by RUNX3 94 3.31e-02 1.27e-01 1.62e-01
Signaling by NODAL 14 3.36e-02 -3.28e-01 1.64e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 3.39e-02 2.50e-01 1.65e-01
Depolymerisation of the Nuclear Lamina 15 3.42e-02 3.16e-01 1.66e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 3.45e-02 1.60e-01 1.67e-01
Signaling by ERBB4 52 3.52e-02 -1.69e-01 1.70e-01
CDT1 association with the CDC6:ORC:origin complex 57 3.55e-02 1.61e-01 1.71e-01
Carboxyterminal post-translational modifications of tubulin 28 3.56e-02 2.29e-01 1.71e-01
Nucleotide-like (purinergic) receptors 15 3.58e-02 -3.13e-01 1.71e-01
Intraflagellar transport 39 3.66e-02 1.93e-01 1.74e-01
RUNX2 regulates osteoblast differentiation 23 3.75e-02 2.51e-01 1.78e-01
Toll Like Receptor 3 (TLR3) Cascade 93 3.79e-02 1.25e-01 1.80e-01
NOD1/2 Signaling Pathway 32 3.90e-02 2.11e-01 1.84e-01
RNA Polymerase I Promoter Opening 14 3.94e-02 3.18e-01 1.85e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.95e-02 2.66e-01 1.85e-01
Cargo trafficking to the periciliary membrane 46 4.00e-02 1.75e-01 1.87e-01
Interleukin-1 signaling 99 4.02e-02 1.19e-01 1.87e-01
MASTL Facilitates Mitotic Progression 10 4.07e-02 3.74e-01 1.88e-01
LGI-ADAM interactions 10 4.08e-02 -3.74e-01 1.88e-01
Reduction of cytosolic Ca++ levels 10 4.09e-02 3.73e-01 1.88e-01
Cyclin D associated events in G1 47 4.20e-02 1.71e-01 1.92e-01
G1 Phase 47 4.20e-02 1.71e-01 1.92e-01
Nitric oxide stimulates guanylate cyclase 18 4.30e-02 -2.76e-01 1.96e-01
Laminin interactions 23 4.35e-02 -2.43e-01 1.98e-01
E2F mediated regulation of DNA replication 22 4.45e-02 2.47e-01 2.02e-01
The role of Nef in HIV-1 replication and disease pathogenesis 27 4.48e-02 -2.23e-01 2.03e-01
CASP8 activity is inhibited 10 4.55e-02 3.65e-01 2.03e-01
Dimerization of procaspase-8 10 4.55e-02 3.65e-01 2.03e-01
Regulation by c-FLIP 10 4.55e-02 3.65e-01 2.03e-01
Ribosomal scanning and start codon recognition 58 4.55e-02 -1.52e-01 2.03e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.67e-02 -3.07e-01 2.08e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 4.68e-02 2.57e-01 2.08e-01
Telomere Maintenance 74 4.70e-02 1.34e-01 2.08e-01
Base-Excision Repair, AP Site Formation 26 4.75e-02 2.25e-01 2.10e-01
G1/S DNA Damage Checkpoints 64 4.84e-02 1.43e-01 2.12e-01
Activation of NF-kappaB in B cells 65 4.84e-02 1.42e-01 2.12e-01
Ras activation upon Ca2+ influx through NMDA receptor 16 5.10e-02 2.82e-01 2.23e-01
Formation of the beta-catenin:TCF transactivating complex 41 5.27e-02 1.75e-01 2.30e-01
RUNX2 regulates bone development 29 5.31e-02 2.08e-01 2.31e-01
HS-GAG degradation 21 5.42e-02 -2.43e-01 2.35e-01
Packaging Of Telomere Ends 16 5.44e-02 2.78e-01 2.35e-01
MET promotes cell motility 28 5.46e-02 -2.10e-01 2.35e-01
Signaling by Retinoic Acid 37 5.59e-02 -1.82e-01 2.40e-01
Regulation of TP53 Activity 153 5.61e-02 8.95e-02 2.40e-01
Formation of the cornified envelope 22 5.63e-02 -2.35e-01 2.41e-01
Synaptic adhesion-like molecules 17 5.74e-02 -2.66e-01 2.45e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 27 5.83e-02 2.11e-01 2.47e-01
Regulation of KIT signaling 16 5.83e-02 -2.73e-01 2.47e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 5.95e-02 1.36e-01 2.51e-01
Signaling by the B Cell Receptor (BCR) 138 6.02e-02 -9.27e-02 2.53e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 6.08e-02 2.55e-01 2.55e-01
Regulation of RUNX2 expression and activity 71 6.26e-02 1.28e-01 2.62e-01
Other semaphorin interactions 19 6.34e-02 2.46e-01 2.64e-01
ESR-mediated signaling 160 6.38e-02 8.50e-02 2.66e-01
TCF dependent signaling in response to WNT 165 6.42e-02 8.35e-02 2.66e-01
Nuclear Receptor transcription pathway 40 6.55e-02 -1.68e-01 2.71e-01
Toll Like Receptor 4 (TLR4) Cascade 127 6.63e-02 9.44e-02 2.73e-01
Transcriptional Regulation by MECP2 49 6.66e-02 1.51e-01 2.74e-01
tRNA processing in the mitochondrion 23 6.70e-02 -2.21e-01 2.75e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 6.73e-02 2.00e-01 2.75e-01
SCF(Skp2)-mediated degradation of p27/p21 59 6.74e-02 1.38e-01 2.75e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 6.80e-02 -2.25e-01 2.76e-01
Interleukin-10 signaling 37 6.81e-02 1.73e-01 2.76e-01
DCC mediated attractive signaling 13 6.90e-02 -2.91e-01 2.79e-01
HS-GAG biosynthesis 24 6.96e-02 -2.14e-01 2.80e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 6.98e-02 2.10e-01 2.81e-01
Protein ubiquitination 68 7.08e-02 1.27e-01 2.84e-01
Assembly of active LPL and LIPC lipase complexes 13 7.11e-02 -2.89e-01 2.84e-01
HDR through Single Strand Annealing (SSA) 36 7.14e-02 1.74e-01 2.84e-01
VLDLR internalisation and degradation 12 7.18e-02 -3.00e-01 2.85e-01
Signaling by NTRK1 (TRKA) 110 7.40e-02 9.86e-02 2.93e-01
Oncogene Induced Senescence 33 7.42e-02 1.80e-01 2.93e-01
Regulation of RUNX1 Expression and Activity 18 7.44e-02 2.43e-01 2.93e-01
Formation of tubulin folding intermediates by CCT/TriC 21 7.48e-02 2.25e-01 2.93e-01
EPH-ephrin mediated repulsion of cells 44 7.48e-02 -1.55e-01 2.93e-01
Vasopressin regulates renal water homeostasis via Aquaporins 35 7.51e-02 -1.74e-01 2.94e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 7.55e-02 2.36e-01 2.94e-01
Gene Silencing by RNA 85 7.55e-02 1.12e-01 2.94e-01
HDACs deacetylate histones 40 7.65e-02 1.62e-01 2.97e-01
Signaling by ALK fusions and activated point mutants 55 7.78e-02 1.38e-01 3.00e-01
Signaling by ALK in cancer 55 7.78e-02 1.38e-01 3.00e-01
Regulation of MECP2 expression and activity 30 7.86e-02 1.86e-01 3.03e-01
Translation initiation complex formation 58 7.92e-02 -1.33e-01 3.04e-01
NoRC negatively regulates rRNA expression 57 7.98e-02 1.34e-01 3.06e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 8.06e-02 1.36e-01 3.07e-01
Nuclear Envelope Breakdown 53 8.11e-02 1.39e-01 3.07e-01
CD28 co-stimulation 32 8.12e-02 -1.78e-01 3.07e-01
RHOBTB2 GTPase cycle 23 8.13e-02 2.10e-01 3.07e-01
Chondroitin sulfate/dermatan sulfate metabolism 46 8.14e-02 -1.49e-01 3.07e-01
O-linked glycosylation of mucins 47 8.33e-02 1.46e-01 3.14e-01
Signaling by Interleukins 391 8.45e-02 5.09e-02 3.18e-01
Cargo recognition for clathrin-mediated endocytosis 95 8.48e-02 -1.02e-01 3.18e-01
Sensory Perception 152 8.51e-02 -8.10e-02 3.18e-01
Keratan sulfate biosynthesis 28 8.56e-02 1.88e-01 3.19e-01
rRNA processing in the mitochondrion 24 8.57e-02 -2.03e-01 3.19e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 8.62e-02 -2.02e-01 3.20e-01
Regulation of PTEN stability and activity 67 8.85e-02 1.20e-01 3.27e-01
Plasma lipoprotein clearance 30 8.85e-02 -1.80e-01 3.27e-01
RAB GEFs exchange GTP for GDP on RABs 87 8.91e-02 1.05e-01 3.28e-01
Phase 4 - resting membrane potential 12 8.98e-02 -2.83e-01 3.29e-01
DNA strand elongation 32 9.00e-02 1.73e-01 3.29e-01
Interleukin-6 family signaling 22 9.01e-02 2.09e-01 3.29e-01
Apoptotic factor-mediated response 20 9.11e-02 2.18e-01 3.32e-01
ABC transporters in lipid homeostasis 13 9.36e-02 -2.69e-01 3.40e-01
TCR signaling 115 9.36e-02 9.05e-02 3.40e-01
Beta-catenin phosphorylation cascade 17 9.39e-02 2.35e-01 3.40e-01
Retrograde neurotrophin signalling 14 9.43e-02 -2.58e-01 3.40e-01
Insulin processing 23 9.48e-02 2.01e-01 3.41e-01
p53-Dependent G1 DNA Damage Response 62 9.58e-02 1.22e-01 3.43e-01
p53-Dependent G1/S DNA damage checkpoint 62 9.58e-02 1.22e-01 3.43e-01
Metabolism of polyamines 57 9.83e-02 1.27e-01 3.50e-01
COPI-independent Golgi-to-ER retrograde traffic 33 9.87e-02 1.66e-01 3.50e-01
Downstream signaling of activated FGFR3 20 9.90e-02 2.13e-01 3.50e-01
HSF1-dependent transactivation 32 9.92e-02 -1.68e-01 3.50e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 9.93e-02 2.87e-01 3.50e-01
Nuclear Envelope (NE) Reassembly 68 9.95e-02 1.16e-01 3.50e-01
Regulation of insulin secretion 62 9.95e-02 -1.21e-01 3.50e-01
C-type lectin receptors (CLRs) 124 9.99e-02 8.56e-02 3.51e-01
SHC-mediated cascade:FGFR3 13 1.00e-01 2.63e-01 3.51e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 1.02e-01 -2.73e-01 3.56e-01
Formation of apoptosome 11 1.03e-01 2.84e-01 3.58e-01
Regulation of the apoptosome activity 11 1.03e-01 2.84e-01 3.58e-01
Sensory processing of sound by inner hair cells of the cochlea 53 1.04e-01 -1.29e-01 3.62e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 1.05e-01 -1.22e-01 3.63e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 51 1.05e-01 1.31e-01 3.63e-01
Class B/2 (Secretin family receptors) 62 1.06e-01 -1.19e-01 3.63e-01
Fc epsilon receptor (FCERI) signaling 158 1.06e-01 -7.46e-02 3.63e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 1.07e-01 2.69e-01 3.66e-01
RUNX3 regulates p14-ARF 10 1.09e-01 2.92e-01 3.74e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.10e-01 1.15e-01 3.76e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.12e-01 1.18e-01 3.77e-01
Cohesin Loading onto Chromatin 10 1.12e-01 2.90e-01 3.77e-01
Signaling by FGFR3 in disease 17 1.12e-01 2.23e-01 3.77e-01
Signaling by FGFR3 point mutants in cancer 17 1.12e-01 2.23e-01 3.77e-01
Base Excision Repair 54 1.12e-01 1.25e-01 3.77e-01
Costimulation by the CD28 family 65 1.12e-01 -1.14e-01 3.77e-01
Biological oxidations 144 1.12e-01 -7.67e-02 3.77e-01
Negative epigenetic regulation of rRNA expression 60 1.13e-01 1.18e-01 3.77e-01
Signaling by FGFR3 fusions in cancer 10 1.13e-01 2.90e-01 3.77e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 1.14e-01 2.53e-01 3.79e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 86 1.14e-01 -9.86e-02 3.79e-01
Aquaporin-mediated transport 38 1.14e-01 -1.48e-01 3.79e-01
Transmission across Chemical Synapses 184 1.15e-01 -6.74e-02 3.81e-01
HDR through MMEJ (alt-NHEJ) 10 1.15e-01 2.88e-01 3.81e-01
RAF-independent MAPK1/3 activation 22 1.16e-01 1.94e-01 3.81e-01
PI3K/AKT Signaling in Cancer 86 1.16e-01 -9.81e-02 3.81e-01
Purine salvage 13 1.17e-01 2.51e-01 3.84e-01
P2Y receptors 11 1.18e-01 -2.72e-01 3.86e-01
TNFR2 non-canonical NF-kB pathway 92 1.18e-01 9.43e-02 3.86e-01
SLC-mediated transmembrane transport 168 1.19e-01 6.98e-02 3.87e-01
Integration of energy metabolism 90 1.19e-01 -9.50e-02 3.88e-01
Transcriptional Regulation by VENTX 39 1.20e-01 1.44e-01 3.89e-01
MECP2 regulates neuronal receptors and channels 14 1.20e-01 2.40e-01 3.89e-01
Adherens junctions interactions 21 1.23e-01 1.95e-01 3.96e-01
Signaling by NOTCH 183 1.25e-01 6.59e-02 4.01e-01
Regulation of TP53 Activity through Phosphorylation 88 1.25e-01 9.46e-02 4.02e-01
Molecules associated with elastic fibres 28 1.26e-01 -1.67e-01 4.03e-01
Ion homeostasis 43 1.26e-01 1.35e-01 4.03e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.27e-01 1.47e-01 4.03e-01
RHO GTPase cycle 426 1.27e-01 4.32e-02 4.03e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 20 1.29e-01 -1.96e-01 4.11e-01
Regulation of TP53 Expression and Degradation 36 1.31e-01 1.46e-01 4.14e-01
Apoptotic execution phase 45 1.33e-01 1.30e-01 4.20e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 19 1.34e-01 1.99e-01 4.21e-01
Neurodegenerative Diseases 19 1.34e-01 1.99e-01 4.21e-01
PKMTs methylate histone lysines 43 1.34e-01 1.32e-01 4.21e-01
Innate Immune System 933 1.34e-01 2.91e-02 4.21e-01
RHOBTB GTPase Cycle 35 1.35e-01 1.46e-01 4.23e-01
Developmental Biology 772 1.36e-01 -3.16e-02 4.26e-01
Metabolism 1802 1.37e-01 -2.13e-02 4.26e-01
Glycogen storage diseases 14 1.37e-01 -2.29e-01 4.26e-01
Methylation 12 1.38e-01 2.48e-01 4.27e-01
Interleukin-1 family signaling 128 1.38e-01 7.60e-02 4.27e-01
GABA synthesis, release, reuptake and degradation 12 1.38e-01 -2.47e-01 4.27e-01
Cytochrome P450 - arranged by substrate type 36 1.39e-01 -1.43e-01 4.29e-01
Pentose phosphate pathway 13 1.39e-01 2.37e-01 4.29e-01
Degradation of beta-catenin by the destruction complex 83 1.40e-01 9.38e-02 4.29e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 33 1.40e-01 -1.48e-01 4.30e-01
Aspartate and asparagine metabolism 10 1.41e-01 -2.69e-01 4.31e-01
Rab regulation of trafficking 120 1.44e-01 7.72e-02 4.39e-01
LDL clearance 19 1.44e-01 -1.93e-01 4.40e-01
Negative regulation of MAPK pathway 42 1.45e-01 1.30e-01 4.41e-01
CaMK IV-mediated phosphorylation of CREB 10 1.46e-01 2.66e-01 4.41e-01
RNA Polymerase I Promoter Escape 42 1.46e-01 1.30e-01 4.41e-01
Diseases associated with O-glycosylation of proteins 57 1.46e-01 -1.11e-01 4.41e-01
Negative regulation of the PI3K/AKT network 93 1.47e-01 -8.71e-02 4.41e-01
Lysosphingolipid and LPA receptors 10 1.47e-01 -2.65e-01 4.41e-01
Early Phase of HIV Life Cycle 14 1.48e-01 2.23e-01 4.45e-01
Protein localization 156 1.50e-01 -6.69e-02 4.48e-01
Interferon Signaling 178 1.51e-01 -6.25e-02 4.49e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 1.51e-01 2.30e-01 4.49e-01
Interleukin-4 and Interleukin-13 signaling 96 1.51e-01 8.48e-02 4.49e-01
Regulation of Apoptosis 51 1.52e-01 1.16e-01 4.50e-01
Activation of BH3-only proteins 30 1.52e-01 1.51e-01 4.50e-01
NR1H2 and NR1H3-mediated signaling 41 1.52e-01 -1.29e-01 4.50e-01
Gluconeogenesis 28 1.53e-01 -1.56e-01 4.50e-01
CD28 dependent PI3K/Akt signaling 21 1.53e-01 -1.80e-01 4.51e-01
Negative regulation of NOTCH4 signaling 54 1.55e-01 1.12e-01 4.55e-01
Glucagon signaling in metabolic regulation 28 1.57e-01 -1.54e-01 4.61e-01
Mitochondrial Fatty Acid Beta-Oxidation 35 1.58e-01 1.38e-01 4.62e-01
tRNA processing 127 1.58e-01 -7.25e-02 4.62e-01
Hedgehog ‘off’ state 96 1.60e-01 8.30e-02 4.67e-01
Attenuation phase 22 1.60e-01 -1.73e-01 4.67e-01
Plasma lipoprotein assembly 13 1.61e-01 -2.24e-01 4.68e-01
Interleukin-6 signaling 11 1.62e-01 2.44e-01 4.68e-01
Cargo concentration in the ER 31 1.62e-01 1.45e-01 4.68e-01
Olfactory Signaling Pathway 11 1.62e-01 -2.44e-01 4.68e-01
Regulation of innate immune responses to cytosolic DNA 14 1.63e-01 -2.15e-01 4.69e-01
Sensory processing of sound 58 1.64e-01 -1.06e-01 4.71e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.65e-01 -2.54e-01 4.72e-01
SUMOylation of intracellular receptors 27 1.65e-01 -1.54e-01 4.73e-01
Signaling by SCF-KIT 43 1.66e-01 -1.22e-01 4.74e-01
Downregulation of TGF-beta receptor signaling 26 1.66e-01 1.57e-01 4.74e-01
Regulation of RUNX3 expression and activity 55 1.67e-01 1.08e-01 4.74e-01
BBSome-mediated cargo-targeting to cilium 22 1.67e-01 1.70e-01 4.74e-01
Regulation of ornithine decarboxylase (ODC) 49 1.68e-01 1.14e-01 4.74e-01
FRS-mediated FGFR3 signaling 15 1.68e-01 2.05e-01 4.74e-01
Dectin-2 family 14 1.68e-01 -2.13e-01 4.74e-01
ADP signalling through P2Y purinoceptor 1 21 1.69e-01 -1.73e-01 4.74e-01
Cleavage of the damaged purine 19 1.69e-01 1.82e-01 4.74e-01
Depurination 19 1.69e-01 1.82e-01 4.74e-01
Recognition and association of DNA glycosylase with site containing an affected purine 19 1.69e-01 1.82e-01 4.74e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.70e-01 2.12e-01 4.76e-01
Downstream signaling of activated FGFR4 19 1.71e-01 1.82e-01 4.76e-01
Dectin-1 mediated noncanonical NF-kB signaling 59 1.72e-01 1.03e-01 4.78e-01
MAPK6/MAPK4 signaling 83 1.73e-01 8.65e-02 4.81e-01
G-protein activation 19 1.73e-01 -1.80e-01 4.81e-01
EGFR downregulation 29 1.74e-01 -1.46e-01 4.83e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 1.76e-01 1.08e-01 4.86e-01
UCH proteinases 86 1.77e-01 8.43e-02 4.88e-01
Downstream TCR signaling 94 1.77e-01 8.06e-02 4.88e-01
Acyl chain remodelling of PI 10 1.79e-01 -2.46e-01 4.89e-01
Transcriptional regulation by small RNAs 58 1.79e-01 1.02e-01 4.89e-01
Cytochrome c-mediated apoptotic response 13 1.79e-01 2.15e-01 4.89e-01
PKA activation in glucagon signalling 16 1.79e-01 -1.94e-01 4.89e-01
CaM pathway 33 1.80e-01 -1.35e-01 4.89e-01
Calmodulin induced events 33 1.80e-01 -1.35e-01 4.89e-01
Caspase activation via Death Receptors in the presence of ligand 15 1.80e-01 2.00e-01 4.89e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 36 1.81e-01 -1.29e-01 4.90e-01
Axon guidance 486 1.82e-01 -3.54e-02 4.92e-01
Defective Intrinsic Pathway for Apoptosis 22 1.82e-01 1.64e-01 4.92e-01
Ephrin signaling 19 1.83e-01 -1.77e-01 4.92e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 1.83e-01 -1.54e-01 4.93e-01
Signaling by GPCR 456 1.84e-01 -3.64e-02 4.93e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 28 1.84e-01 1.45e-01 4.93e-01
HSF1 activation 25 1.84e-01 -1.53e-01 4.93e-01
Regulation of TP53 Degradation 35 1.85e-01 1.30e-01 4.93e-01
Extension of Telomeres 49 1.86e-01 1.09e-01 4.94e-01
RAB geranylgeranylation 60 1.86e-01 9.88e-02 4.94e-01
GPVI-mediated activation cascade 30 1.86e-01 -1.40e-01 4.94e-01
Signal amplification 28 1.88e-01 -1.44e-01 4.99e-01
Metabolism of steroids 124 1.89e-01 6.83e-02 5.00e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.90e-01 2.19e-01 5.01e-01
alpha-linolenic acid (ALA) metabolism 12 1.90e-01 2.19e-01 5.01e-01
SUMOylation 168 1.92e-01 5.84e-02 5.05e-01
SHC-mediated cascade:FGFR4 12 1.92e-01 2.18e-01 5.05e-01
InlB-mediated entry of Listeria monocytogenes into host cell 14 1.93e-01 -2.01e-01 5.05e-01
Platelet sensitization by LDL 17 1.93e-01 1.82e-01 5.05e-01
Prostacyclin signalling through prostacyclin receptor 15 1.94e-01 -1.94e-01 5.06e-01
Ovarian tumor domain proteases 38 1.96e-01 1.21e-01 5.12e-01
Class I peroxisomal membrane protein import 19 1.97e-01 -1.71e-01 5.13e-01
Interleukin-20 family signaling 17 1.98e-01 1.80e-01 5.14e-01
Activation of HOX genes during differentiation 70 1.98e-01 8.89e-02 5.14e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 1.98e-01 8.89e-02 5.14e-01
Uptake and function of anthrax toxins 11 2.00e-01 2.23e-01 5.17e-01
Oncogenic MAPK signaling 75 2.00e-01 8.55e-02 5.17e-01
NIK–>noncanonical NF-kB signaling 57 2.00e-01 9.81e-02 5.17e-01
RNA Polymerase III Transcription Termination 23 2.02e-01 -1.54e-01 5.18e-01
Signaling by WNT 252 2.02e-01 4.68e-02 5.18e-01
TP53 Regulates Metabolic Genes 86 2.03e-01 7.95e-02 5.18e-01
Sensory processing of sound by outer hair cells of the cochlea 41 2.03e-01 -1.15e-01 5.18e-01
Vif-mediated degradation of APOBEC3G 52 2.04e-01 1.02e-01 5.18e-01
Pausing and recovery of Tat-mediated HIV elongation 30 2.04e-01 -1.34e-01 5.18e-01
Tat-mediated HIV elongation arrest and recovery 30 2.04e-01 -1.34e-01 5.18e-01
Activation of BAD and translocation to mitochondria 15 2.04e-01 1.89e-01 5.18e-01
Inhibition of DNA recombination at telomere 31 2.05e-01 1.32e-01 5.18e-01
Keratan sulfate/keratin metabolism 33 2.05e-01 1.28e-01 5.18e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 2.06e-01 1.03e-01 5.20e-01
p53-Independent DNA Damage Response 50 2.06e-01 1.03e-01 5.20e-01
p53-Independent G1/S DNA damage checkpoint 50 2.06e-01 1.03e-01 5.20e-01
EPHB-mediated forward signaling 32 2.09e-01 1.28e-01 5.23e-01
COPII-mediated vesicle transport 66 2.09e-01 8.95e-02 5.23e-01
PKA activation 17 2.10e-01 -1.76e-01 5.26e-01
RIP-mediated NFkB activation via ZBP1 17 2.11e-01 1.75e-01 5.27e-01
Phase 2 - plateau phase 10 2.13e-01 -2.28e-01 5.31e-01
GRB2 events in ERBB2 signaling 14 2.14e-01 -1.92e-01 5.33e-01
Death Receptor Signalling 136 2.14e-01 6.17e-02 5.33e-01
Acyl chain remodelling of PE 19 2.15e-01 -1.64e-01 5.33e-01
RNA Polymerase III Abortive And Retractive Initiation 41 2.16e-01 -1.12e-01 5.33e-01
RNA Polymerase III Transcription 41 2.16e-01 -1.12e-01 5.33e-01
PI-3K cascade:FGFR3 13 2.16e-01 1.98e-01 5.34e-01
HIV elongation arrest and recovery 32 2.19e-01 -1.26e-01 5.37e-01
Pausing and recovery of HIV elongation 32 2.19e-01 -1.26e-01 5.37e-01
Platelet calcium homeostasis 22 2.19e-01 1.51e-01 5.37e-01
Mitophagy 28 2.19e-01 -1.34e-01 5.37e-01
Ubiquitin-dependent degradation of Cyclin D 50 2.19e-01 1.00e-01 5.37e-01
Downstream signaling of activated FGFR2 22 2.20e-01 1.51e-01 5.39e-01
Regulation of HMOX1 expression and activity 63 2.21e-01 8.91e-02 5.40e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 2.22e-01 -2.23e-01 5.40e-01
Cellular response to hypoxia 72 2.22e-01 8.33e-02 5.40e-01
Metabolism of Angiotensinogen to Angiotensins 15 2.23e-01 -1.82e-01 5.40e-01
Inositol phosphate metabolism 45 2.23e-01 1.05e-01 5.40e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 2.24e-01 1.26e-01 5.41e-01
Platelet activation, signaling and aggregation 227 2.24e-01 -4.68e-02 5.41e-01
Negative regulation of FLT3 14 2.24e-01 -1.88e-01 5.41e-01
Regulation of FOXO transcriptional activity by acetylation 10 2.25e-01 -2.22e-01 5.41e-01
Glucagon-type ligand receptors 22 2.25e-01 -1.49e-01 5.41e-01
Regulation of FZD by ubiquitination 17 2.25e-01 -1.70e-01 5.41e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.26e-01 2.02e-01 5.42e-01
ALK mutants bind TKIs 12 2.28e-01 2.01e-01 5.45e-01
PKA-mediated phosphorylation of CREB 19 2.29e-01 -1.59e-01 5.46e-01
Cellular response to starvation 151 2.29e-01 -5.68e-02 5.46e-01
SUMO E3 ligases SUMOylate target proteins 162 2.30e-01 5.46e-02 5.48e-01
Signaling by FGFR4 in disease 10 2.31e-01 2.19e-01 5.48e-01
Myogenesis 22 2.31e-01 1.47e-01 5.48e-01
Regulation of signaling by CBL 18 2.31e-01 -1.63e-01 5.48e-01
Signaling by FGFR1 in disease 33 2.33e-01 1.20e-01 5.52e-01
RMTs methylate histone arginines 35 2.34e-01 1.16e-01 5.53e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 10 2.36e-01 2.16e-01 5.56e-01
ZBP1(DAI) mediated induction of type I IFNs 20 2.38e-01 1.52e-01 5.59e-01
Constitutive Signaling by Overexpressed ERBB2 11 2.39e-01 2.05e-01 5.59e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 2.40e-01 2.05e-01 5.59e-01
Metabolism of non-coding RNA 53 2.41e-01 -9.31e-02 5.59e-01
snRNP Assembly 53 2.41e-01 -9.31e-02 5.59e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 2.42e-01 1.75e-01 5.59e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 2.42e-01 1.75e-01 5.59e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 2.42e-01 1.75e-01 5.59e-01
Signaling by CTNNB1 phospho-site mutants 15 2.42e-01 1.75e-01 5.59e-01
Signaling by GSK3beta mutants 15 2.42e-01 1.75e-01 5.59e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 2.42e-01 1.75e-01 5.59e-01
Diseases associated with glycosaminoglycan metabolism 38 2.42e-01 -1.10e-01 5.59e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 2.42e-01 9.76e-02 5.59e-01
Ca2+ pathway 57 2.43e-01 8.94e-02 5.60e-01
N-Glycan antennae elongation 13 2.43e-01 1.87e-01 5.60e-01
Suppression of phagosomal maturation 13 2.44e-01 1.87e-01 5.60e-01
RHO GTPases activate PKNs 42 2.45e-01 1.04e-01 5.62e-01
RET signaling 37 2.45e-01 -1.10e-01 5.62e-01
Telomere Extension By Telomerase 21 2.49e-01 1.45e-01 5.67e-01
Signaling by CSF3 (G-CSF) 29 2.49e-01 1.24e-01 5.67e-01
Toll-like Receptor Cascades 148 2.49e-01 5.49e-02 5.67e-01
IKK complex recruitment mediated by RIP1 23 2.49e-01 1.39e-01 5.67e-01
RHOU GTPase cycle 40 2.51e-01 -1.05e-01 5.69e-01
FOXO-mediated transcription of cell cycle genes 16 2.51e-01 1.66e-01 5.69e-01
Receptor Mediated Mitophagy 11 2.51e-01 -2.00e-01 5.69e-01
Trafficking and processing of endosomal TLR 13 2.53e-01 -1.83e-01 5.72e-01
Diseases of carbohydrate metabolism 29 2.54e-01 -1.22e-01 5.75e-01
Adaptive Immune System 703 2.56e-01 2.52e-02 5.78e-01
mRNA Splicing 187 2.58e-01 -4.80e-02 5.81e-01
Platelet degranulation 111 2.60e-01 -6.19e-02 5.85e-01
Platelet Adhesion to exposed collagen 10 2.62e-01 2.05e-01 5.87e-01
Cellular responses to stress 667 2.64e-01 2.54e-02 5.89e-01
Constitutive Signaling by EGFRvIII 15 2.64e-01 1.67e-01 5.89e-01
Signaling by EGFRvIII in Cancer 15 2.64e-01 1.67e-01 5.89e-01
SCF-beta-TrCP mediated degradation of Emi1 53 2.65e-01 8.86e-02 5.89e-01
Signaling by ALK 27 2.65e-01 1.24e-01 5.89e-01
WNT5A-dependent internalization of FZD4 14 2.65e-01 -1.72e-01 5.89e-01
Effects of PIP2 hydrolysis 23 2.65e-01 1.34e-01 5.89e-01
Integrin cell surface interactions 58 2.66e-01 8.45e-02 5.89e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 71 2.66e-01 7.63e-02 5.89e-01
mRNA Splicing - Major Pathway 179 2.67e-01 -4.81e-02 5.89e-01
DNA Double Strand Break Response 46 2.67e-01 9.46e-02 5.89e-01
SHC-mediated cascade:FGFR2 15 2.67e-01 1.65e-01 5.89e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 2.71e-01 -1.84e-01 5.95e-01
Signalling to ERKs 33 2.71e-01 1.11e-01 5.95e-01
GLI3 is processed to GLI3R by the proteasome 57 2.71e-01 8.42e-02 5.95e-01
Vpu mediated degradation of CD4 50 2.75e-01 8.92e-02 6.03e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 15 2.76e-01 1.63e-01 6.03e-01
Degradation of DVL 55 2.82e-01 8.39e-02 6.15e-01
mRNA Capping 29 2.82e-01 1.15e-01 6.15e-01
Cytokine Signaling in Immune system 612 2.84e-01 2.54e-02 6.19e-01
Phase II - Conjugation of compounds 69 2.85e-01 7.44e-02 6.19e-01
PERK regulates gene expression 32 2.85e-01 1.09e-01 6.19e-01
Glutathione conjugation 30 2.87e-01 1.12e-01 6.19e-01
GPCR downstream signalling 409 2.87e-01 -3.07e-02 6.19e-01
Thromboxane signalling through TP receptor 20 2.88e-01 -1.37e-01 6.19e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 2.88e-01 1.18e-01 6.19e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 2.89e-01 -1.18e-01 6.19e-01
Activation of the AP-1 family of transcription factors 10 2.89e-01 1.94e-01 6.19e-01
Downregulation of ERBB2 signaling 27 2.89e-01 -1.18e-01 6.19e-01
Signaling by BRAF and RAF1 fusions 59 2.90e-01 7.97e-02 6.19e-01
Degradation of GLI2 by the proteasome 57 2.90e-01 8.11e-02 6.19e-01
TGF-beta receptor signaling activates SMADs 32 2.90e-01 1.08e-01 6.19e-01
SUMOylation of DNA damage response and repair proteins 77 2.90e-01 6.97e-02 6.19e-01
Activation of RAC1 11 2.91e-01 -1.84e-01 6.21e-01
Acetylcholine regulates insulin secretion 10 2.92e-01 -1.92e-01 6.22e-01
activated TAK1 mediates p38 MAPK activation 19 2.93e-01 1.39e-01 6.22e-01
Synthesis of very long-chain fatty acyl-CoAs 21 2.93e-01 1.32e-01 6.22e-01
FRS-mediated FGFR4 signaling 14 2.94e-01 1.62e-01 6.22e-01
TNF signaling 44 2.94e-01 9.14e-02 6.22e-01
Signaling by Activin 14 2.94e-01 -1.62e-01 6.22e-01
Acyl chain remodelling of PC 19 2.95e-01 -1.39e-01 6.22e-01
B-WICH complex positively regulates rRNA expression 42 2.96e-01 9.32e-02 6.23e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.96e-01 1.38e-01 6.23e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 2.97e-01 1.82e-01 6.23e-01
NOTCH2 intracellular domain regulates transcription 11 2.98e-01 1.81e-01 6.24e-01
Positive epigenetic regulation of rRNA expression 57 2.99e-01 7.96e-02 6.26e-01
The canonical retinoid cycle in rods (twilight vision) 13 3.02e-01 -1.65e-01 6.31e-01
Regulation of IFNA signaling 12 3.02e-01 1.72e-01 6.31e-01
ADP signalling through P2Y purinoceptor 12 17 3.04e-01 -1.44e-01 6.32e-01
RNA Polymerase I Promoter Clearance 61 3.04e-01 7.61e-02 6.32e-01
RNA Polymerase I Transcription 61 3.04e-01 7.61e-02 6.32e-01
Inwardly rectifying K+ channels 23 3.06e-01 -1.23e-01 6.33e-01
Membrane binding and targetting of GAG proteins 14 3.06e-01 -1.58e-01 6.33e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 3.06e-01 -1.58e-01 6.33e-01
Nervous system development 507 3.07e-01 -2.66e-02 6.34e-01
ER-Phagosome pathway 85 3.08e-01 6.40e-02 6.36e-01
p130Cas linkage to MAPK signaling for integrins 12 3.10e-01 -1.69e-01 6.38e-01
Degradation of GLI1 by the proteasome 57 3.10e-01 7.78e-02 6.38e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.12e-01 -1.69e-01 6.40e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 3.14e-01 -1.56e-01 6.40e-01
Defective EXT2 causes exostoses 2 14 3.14e-01 -1.56e-01 6.40e-01
Signaling by ERBB2 TMD/JMD mutants 20 3.14e-01 -1.30e-01 6.40e-01
Hyaluronan uptake and degradation 11 3.14e-01 -1.75e-01 6.40e-01
GABA receptor activation 40 3.15e-01 -9.18e-02 6.40e-01
Nucleotide salvage 22 3.15e-01 1.24e-01 6.40e-01
Adenylate cyclase activating pathway 10 3.16e-01 -1.83e-01 6.40e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 3.16e-01 -1.50e-01 6.40e-01
RAS processing 19 3.16e-01 1.33e-01 6.40e-01
Mitochondrial translation elongation 90 3.17e-01 -6.11e-02 6.40e-01
MAP kinase activation 63 3.17e-01 7.29e-02 6.40e-01
Mitochondrial iron-sulfur cluster biogenesis 13 3.18e-01 -1.60e-01 6.40e-01
Activation of GABAB receptors 32 3.18e-01 -1.02e-01 6.40e-01
GABA B receptor activation 32 3.18e-01 -1.02e-01 6.40e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 27 3.21e-01 1.10e-01 6.46e-01
Regulation of beta-cell development 21 3.23e-01 1.25e-01 6.46e-01
Listeria monocytogenes entry into host cells 18 3.23e-01 -1.35e-01 6.46e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 97 3.23e-01 5.80e-02 6.46e-01
Toll Like Receptor 2 (TLR2) Cascade 97 3.23e-01 5.80e-02 6.46e-01
Toll Like Receptor TLR1:TLR2 Cascade 97 3.23e-01 5.80e-02 6.46e-01
Toll Like Receptor TLR6:TLR2 Cascade 97 3.23e-01 5.80e-02 6.46e-01
Protein methylation 15 3.25e-01 1.47e-01 6.48e-01
p38MAPK events 13 3.26e-01 1.57e-01 6.48e-01
Basigin interactions 23 3.27e-01 1.18e-01 6.48e-01
Peroxisomal protein import 57 3.27e-01 -7.51e-02 6.48e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 37 3.27e-01 -9.31e-02 6.48e-01
p75NTR recruits signalling complexes 13 3.27e-01 1.57e-01 6.48e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 13 3.28e-01 -1.57e-01 6.48e-01
Sialic acid metabolism 28 3.29e-01 1.06e-01 6.50e-01
PD-1 signaling 23 3.30e-01 -1.17e-01 6.50e-01
Gap junction trafficking and regulation 20 3.33e-01 -1.25e-01 6.55e-01
SLBP independent Processing of Histone Pre-mRNAs 10 3.33e-01 1.77e-01 6.55e-01
RHOBTB1 GTPase cycle 23 3.34e-01 1.16e-01 6.55e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 30 3.35e-01 -1.02e-01 6.56e-01
Peroxisomal lipid metabolism 26 3.35e-01 -1.09e-01 6.56e-01
Sema3A PAK dependent Axon repulsion 16 3.35e-01 -1.39e-01 6.56e-01
Caspase activation via extrinsic apoptotic signalling pathway 23 3.36e-01 1.16e-01 6.57e-01
Signaling by TGF-beta Receptor Complex 73 3.37e-01 6.50e-02 6.57e-01
Metabolism of fat-soluble vitamins 34 3.38e-01 -9.51e-02 6.57e-01
Signaling by NTRKs 127 3.38e-01 4.92e-02 6.58e-01
Advanced glycosylation endproduct receptor signaling 13 3.39e-01 -1.53e-01 6.58e-01
Diseases associated with N-glycosylation of proteins 17 3.39e-01 -1.34e-01 6.58e-01
Gap junction trafficking 18 3.40e-01 -1.30e-01 6.58e-01
Regulated proteolysis of p75NTR 11 3.40e-01 -1.66e-01 6.58e-01
Stabilization of p53 54 3.41e-01 7.49e-02 6.59e-01
Signalling to RAS 20 3.42e-01 1.23e-01 6.59e-01
Common Pathway of Fibrin Clot Formation 13 3.42e-01 1.52e-01 6.59e-01
Degradation of the extracellular matrix 91 3.43e-01 5.75e-02 6.60e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 3.44e-01 7.82e-02 6.61e-01
Inactivation of CSF3 (G-CSF) signaling 24 3.45e-01 1.11e-01 6.62e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 45 3.45e-01 8.13e-02 6.62e-01
NCAM signaling for neurite out-growth 51 3.47e-01 -7.62e-02 6.63e-01
Carnitine metabolism 12 3.47e-01 -1.57e-01 6.63e-01
The phototransduction cascade 23 3.47e-01 1.13e-01 6.63e-01
Pyroptosis 24 3.49e-01 1.10e-01 6.66e-01
Signaling by NOTCH1 72 3.51e-01 -6.36e-02 6.67e-01
ROS sensing by NFE2L2 55 3.51e-01 7.26e-02 6.68e-01
Metabolism of porphyrins 21 3.52e-01 -1.17e-01 6.68e-01
Signaling by FGFR3 35 3.53e-01 9.08e-02 6.69e-01
p75NTR signals via NF-kB 16 3.54e-01 1.34e-01 6.70e-01
Metabolism of carbohydrates 260 3.55e-01 -3.34e-02 6.70e-01
Pyruvate metabolism 27 3.55e-01 1.03e-01 6.71e-01
Sema4D induced cell migration and growth-cone collapse 20 3.56e-01 1.19e-01 6.71e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.57e-01 -1.11e-01 6.71e-01
Signaling by FLT3 fusion proteins 19 3.57e-01 1.22e-01 6.71e-01
Degradation of AXIN 53 3.58e-01 7.30e-02 6.72e-01
Post-chaperonin tubulin folding pathway 18 3.58e-01 1.25e-01 6.72e-01
IRAK4 deficiency (TLR2/4) 15 3.58e-01 1.37e-01 6.72e-01
Dissolution of Fibrin Clot 10 3.60e-01 -1.67e-01 6.73e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 3.62e-01 1.28e-01 6.75e-01
Hedgehog ‘on’ state 82 3.62e-01 5.83e-02 6.75e-01
Synthesis of PE 12 3.62e-01 1.52e-01 6.75e-01
Folding of actin by CCT/TriC 10 3.63e-01 1.66e-01 6.75e-01
G beta:gamma signalling through PI3Kgamma 21 3.63e-01 -1.15e-01 6.75e-01
Glycosaminoglycan metabolism 110 3.64e-01 -5.02e-02 6.75e-01
Alpha-protein kinase 1 signaling pathway 11 3.64e-01 1.58e-01 6.75e-01
Nuclear Pore Complex (NPC) Disassembly 36 3.65e-01 8.73e-02 6.76e-01
Signaling by FGFR in disease 54 3.67e-01 7.10e-02 6.79e-01
Peptide hormone metabolism 61 3.68e-01 6.67e-02 6.79e-01
DAP12 interactions 38 3.68e-01 8.44e-02 6.79e-01
FRS-mediated FGFR2 signaling 17 3.69e-01 1.26e-01 6.80e-01
RNA Polymerase II Transcription Termination 65 3.70e-01 6.44e-02 6.80e-01
Ca-dependent events 35 3.70e-01 -8.75e-02 6.80e-01
Synthesis of PC 25 3.73e-01 1.03e-01 6.84e-01
Signal transduction by L1 21 3.73e-01 -1.12e-01 6.85e-01
SUMOylation of DNA replication proteins 46 3.74e-01 7.57e-02 6.85e-01
Signaling by FGFR2 in disease 35 3.76e-01 8.64e-02 6.88e-01
VxPx cargo-targeting to cilium 17 3.78e-01 1.24e-01 6.88e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.78e-01 9.80e-02 6.88e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.78e-01 9.80e-02 6.88e-01
PI-3K cascade:FGFR4 12 3.78e-01 1.47e-01 6.88e-01
MHC class II antigen presentation 100 3.82e-01 5.07e-02 6.93e-01
SUMOylation of DNA methylation proteins 16 3.82e-01 1.26e-01 6.93e-01
Visual phototransduction 65 3.83e-01 -6.26e-02 6.94e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 3.85e-01 5.92e-02 6.96e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 24 3.86e-01 1.02e-01 6.96e-01
APC truncation mutants have impaired AXIN binding 14 3.88e-01 1.33e-01 6.96e-01
AXIN missense mutants destabilize the destruction complex 14 3.88e-01 1.33e-01 6.96e-01
Signaling by AMER1 mutants 14 3.88e-01 1.33e-01 6.96e-01
Signaling by APC mutants 14 3.88e-01 1.33e-01 6.96e-01
Signaling by AXIN mutants 14 3.88e-01 1.33e-01 6.96e-01
Truncations of AMER1 destabilize the destruction complex 14 3.88e-01 1.33e-01 6.96e-01
Triglyceride catabolism 16 3.88e-01 -1.25e-01 6.96e-01
Transport of Mature Transcript to Cytoplasm 81 3.91e-01 5.52e-02 6.99e-01
Signaling by FGFR2 IIIa TM 19 3.91e-01 1.14e-01 6.99e-01
RAF activation 34 3.92e-01 8.49e-02 6.99e-01
The citric acid (TCA) cycle and respiratory electron transport 172 3.92e-01 3.78e-02 6.99e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 17 3.93e-01 -1.20e-01 6.99e-01
Signaling by NOTCH4 81 3.93e-01 5.49e-02 6.99e-01
RUNX3 regulates NOTCH signaling 14 3.94e-01 1.32e-01 7.00e-01
Phase 0 - rapid depolarisation 24 3.95e-01 -1.00e-01 7.01e-01
The NLRP3 inflammasome 16 3.96e-01 1.23e-01 7.02e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 3.96e-01 1.41e-01 7.02e-01
COPI-mediated anterograde transport 81 3.98e-01 -5.43e-02 7.04e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 3.99e-01 -8.90e-02 7.04e-01
G alpha (i) signalling events 205 3.99e-01 3.42e-02 7.04e-01
SHC1 events in ERBB2 signaling 20 4.01e-01 -1.08e-01 7.07e-01
Association of TriC/CCT with target proteins during biosynthesis 37 4.02e-01 7.97e-02 7.07e-01
Signaling by Leptin 11 4.02e-01 1.46e-01 7.07e-01
Nucleotide catabolism 25 4.03e-01 9.67e-02 7.07e-01
Regulation of PTEN gene transcription 59 4.04e-01 6.28e-02 7.07e-01
Cellular response to heat stress 96 4.05e-01 -4.93e-02 7.07e-01
Transport of small molecules 554 4.05e-01 2.08e-02 7.07e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 24 4.05e-01 9.83e-02 7.07e-01
Cellular responses to stimuli 676 4.06e-01 1.88e-02 7.08e-01
Activation of NMDA receptors and postsynaptic events 66 4.06e-01 -5.91e-02 7.08e-01
SLC transporter disorders 73 4.07e-01 -5.61e-02 7.09e-01
Diseases associated with glycosylation precursor biosynthesis 18 4.08e-01 -1.13e-01 7.09e-01
MyD88 cascade initiated on plasma membrane 83 4.12e-01 5.21e-02 7.13e-01
Toll Like Receptor 10 (TLR10) Cascade 83 4.12e-01 5.21e-02 7.13e-01
Toll Like Receptor 5 (TLR5) Cascade 83 4.12e-01 5.21e-02 7.13e-01
Extra-nuclear estrogen signaling 68 4.12e-01 5.75e-02 7.13e-01
Mitochondrial translation initiation 90 4.14e-01 -4.99e-02 7.14e-01
Insulin receptor signalling cascade 41 4.14e-01 7.38e-02 7.14e-01
Autophagy 127 4.14e-01 -4.20e-02 7.14e-01
Transport of bile salts and organic acids, metal ions and amine compounds 52 4.16e-01 6.52e-02 7.16e-01
The activation of arylsulfatases 10 4.16e-01 -1.48e-01 7.16e-01
FLT3 Signaling 37 4.17e-01 -7.72e-02 7.16e-01
Opioid Signalling 82 4.18e-01 -5.17e-02 7.17e-01
RAC1 GTPase cycle 177 4.19e-01 3.53e-02 7.17e-01
Lysosome Vesicle Biogenesis 33 4.19e-01 -8.13e-02 7.17e-01
Trafficking of GluR2-containing AMPA receptors 14 4.21e-01 -1.24e-01 7.20e-01
Assembly Of The HIV Virion 16 4.23e-01 -1.16e-01 7.22e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 4.25e-01 1.09e-01 7.24e-01
RORA activates gene expression 18 4.25e-01 -1.09e-01 7.24e-01
Dual incision in TC-NER 65 4.26e-01 -5.71e-02 7.25e-01
G beta:gamma signalling through PLC beta 16 4.27e-01 -1.15e-01 7.26e-01
Arachidonic acid metabolism 38 4.29e-01 -7.42e-02 7.27e-01
Ion transport by P-type ATPases 42 4.29e-01 7.05e-02 7.27e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 4.29e-01 -1.11e-01 7.27e-01
Adenylate cyclase inhibitory pathway 13 4.30e-01 -1.27e-01 7.27e-01
Muscle contraction 151 4.31e-01 -3.71e-02 7.28e-01
IL-6-type cytokine receptor ligand interactions 15 4.32e-01 1.17e-01 7.28e-01
Metal ion SLC transporters 20 4.32e-01 1.01e-01 7.28e-01
Cardiac conduction 93 4.33e-01 -4.71e-02 7.28e-01
Neurotransmitter receptors and postsynaptic signal transmission 133 4.33e-01 -3.94e-02 7.28e-01
Amyloid fiber formation 47 4.34e-01 6.60e-02 7.29e-01
Signal regulatory protein family interactions 11 4.37e-01 -1.35e-01 7.32e-01
MAPK family signaling cascades 283 4.37e-01 2.69e-02 7.32e-01
RHO GTPases activate KTN1 10 4.37e-01 1.42e-01 7.32e-01
Beta-catenin independent WNT signaling 137 4.41e-01 3.82e-02 7.36e-01
Diseases of signal transduction by growth factor receptors and second messengers 395 4.41e-01 2.26e-02 7.36e-01
Antigen processing-Cross presentation 100 4.42e-01 4.45e-02 7.36e-01
Signaling by PDGFR in disease 20 4.42e-01 9.94e-02 7.36e-01
Apoptotic cleavage of cellular proteins 35 4.44e-01 7.47e-02 7.39e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.45e-01 1.22e-01 7.40e-01
Disorders of transmembrane transporters 141 4.49e-01 -3.70e-02 7.45e-01
SUMOylation of immune response proteins 11 4.50e-01 1.32e-01 7.45e-01
EPHA-mediated growth cone collapse 15 4.50e-01 -1.13e-01 7.45e-01
Hh mutants are degraded by ERAD 53 4.50e-01 6.00e-02 7.45e-01
Signaling by ERBB2 KD Mutants 23 4.51e-01 -9.07e-02 7.46e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 4.53e-01 8.35e-02 7.47e-01
IRE1alpha activates chaperones 50 4.53e-01 -6.14e-02 7.47e-01
MyD88 deficiency (TLR2/4) 14 4.54e-01 1.16e-01 7.48e-01
ECM proteoglycans 50 4.56e-01 -6.10e-02 7.49e-01
Regulation of TNFR1 signaling 35 4.57e-01 7.27e-02 7.49e-01
EPH-Ephrin signaling 85 4.57e-01 -4.67e-02 7.49e-01
Fatty acyl-CoA biosynthesis 33 4.57e-01 7.49e-02 7.49e-01
Inactivation, recovery and regulation of the phototransduction cascade 22 4.58e-01 9.15e-02 7.49e-01
Mitochondrial translation termination 90 4.58e-01 -4.53e-02 7.49e-01
Retinoid metabolism and transport 31 4.59e-01 -7.69e-02 7.50e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 4.59e-01 5.99e-02 7.50e-01
RHOH GTPase cycle 33 4.63e-01 7.39e-02 7.55e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.64e-01 1.17e-01 7.56e-01
FGFR2 alternative splicing 24 4.65e-01 8.62e-02 7.56e-01
PI-3K cascade:FGFR2 15 4.65e-01 1.09e-01 7.56e-01
Processing of Capped Intron-Containing Pre-mRNA 238 4.66e-01 -2.74e-02 7.56e-01
Signaling by FGFR 72 4.67e-01 4.96e-02 7.56e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 4.68e-01 -7.09e-02 7.56e-01
HATs acetylate histones 86 4.68e-01 4.53e-02 7.56e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 4.68e-01 5.76e-02 7.56e-01
Response to elevated platelet cytosolic Ca2+ 115 4.71e-01 -3.89e-02 7.58e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 4.72e-01 -1.25e-01 7.58e-01
Rap1 signalling 14 4.72e-01 1.11e-01 7.58e-01
Signaling by EGFR in Cancer 24 4.73e-01 8.47e-02 7.58e-01
Regulation of HSF1-mediated heat shock response 78 4.73e-01 -4.70e-02 7.58e-01
Cytoprotection by HMOX1 119 4.73e-01 3.81e-02 7.58e-01
Nicotinamide salvaging 17 4.74e-01 1.00e-01 7.58e-01
G beta:gamma signalling through BTK 14 4.74e-01 -1.10e-01 7.58e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 4.75e-01 9.47e-02 7.58e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 4.75e-01 9.47e-02 7.58e-01
Interleukin-2 family signaling 36 4.76e-01 -6.87e-02 7.58e-01
Lysine catabolism 11 4.76e-01 1.24e-01 7.58e-01
Potential therapeutics for SARS 81 4.76e-01 4.58e-02 7.58e-01
Signaling by Erythropoietin 24 4.76e-01 8.40e-02 7.58e-01
Vitamin B5 (pantothenate) metabolism 17 4.77e-01 9.97e-02 7.58e-01
CTLA4 inhibitory signaling 19 4.78e-01 9.39e-02 7.59e-01
Downregulation of ERBB2:ERBB3 signaling 13 4.79e-01 -1.13e-01 7.59e-01
Budding and maturation of HIV virion 27 4.79e-01 -7.87e-02 7.59e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 30 4.81e-01 -7.44e-02 7.60e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 4.81e-01 1.05e-01 7.60e-01
Transport of vitamins, nucleosides, and related molecules 32 4.82e-01 -7.18e-02 7.61e-01
Endogenous sterols 22 4.83e-01 -8.65e-02 7.61e-01
Negative regulation of MET activity 20 4.85e-01 -9.02e-02 7.62e-01
CS/DS degradation 11 4.85e-01 -1.22e-01 7.62e-01
Processing of Intronless Pre-mRNAs 19 4.85e-01 -9.25e-02 7.62e-01
Nicotinate metabolism 28 4.85e-01 -7.63e-02 7.62e-01
Signaling by ERBB2 ECD mutants 16 4.86e-01 1.01e-01 7.62e-01
PIP3 activates AKT signaling 246 4.86e-01 2.58e-02 7.62e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 4.87e-01 1.27e-01 7.62e-01
Deadenylation of mRNA 22 4.89e-01 8.52e-02 7.64e-01
O-glycosylation of TSR domain-containing proteins 37 4.90e-01 -6.57e-02 7.64e-01
Defective B3GALTL causes PpS 36 4.90e-01 -6.65e-02 7.64e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 4.91e-01 9.64e-02 7.64e-01
XBP1(S) activates chaperone genes 48 4.91e-01 -5.74e-02 7.64e-01
NCAM1 interactions 30 4.92e-01 -7.25e-02 7.64e-01
Interleukin-7 signaling 20 4.92e-01 -8.87e-02 7.64e-01
Inflammasomes 21 4.93e-01 8.65e-02 7.64e-01
Neurotransmitter release cycle 40 4.94e-01 -6.26e-02 7.64e-01
Pexophagy 11 4.94e-01 -1.19e-01 7.64e-01
Synthesis of PIPs at the plasma membrane 51 4.94e-01 5.53e-02 7.64e-01
Synthesis, secretion, and deacylation of Ghrelin 14 4.95e-01 -1.05e-01 7.65e-01
Cross-presentation of soluble exogenous antigens (endosomes) 47 4.98e-01 5.72e-02 7.68e-01
Antiviral mechanism by IFN-stimulated genes 80 5.01e-01 4.35e-02 7.73e-01
Postmitotic nuclear pore complex (NPC) reformation 27 5.02e-01 7.46e-02 7.73e-01
Hemostasis 522 5.03e-01 -1.72e-02 7.73e-01
Cell-cell junction organization 40 5.03e-01 6.12e-02 7.73e-01
Chaperone Mediated Autophagy 19 5.04e-01 8.85e-02 7.73e-01
MicroRNA (miRNA) biogenesis 26 5.06e-01 7.54e-02 7.73e-01
GAB1 signalosome 16 5.06e-01 -9.59e-02 7.73e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 5.09e-01 -1.06e-01 7.73e-01
SHC-mediated cascade:FGFR1 14 5.09e-01 1.02e-01 7.73e-01
HIV Transcription Initiation 45 5.09e-01 5.69e-02 7.73e-01
RNA Polymerase II HIV Promoter Escape 45 5.09e-01 5.69e-02 7.73e-01
RNA Polymerase II Promoter Escape 45 5.09e-01 5.69e-02 7.73e-01
RNA Polymerase II Transcription Initiation 45 5.09e-01 5.69e-02 7.73e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 5.09e-01 5.69e-02 7.73e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 5.09e-01 5.69e-02 7.73e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 5.10e-01 -5.56e-02 7.73e-01
Assembly and cell surface presentation of NMDA receptors 22 5.12e-01 -8.07e-02 7.76e-01
Transcriptional regulation of pluripotent stem cells 16 5.12e-01 9.46e-02 7.76e-01
RAC3 GTPase cycle 88 5.13e-01 4.03e-02 7.76e-01
Metabolism of vitamins and cofactors 161 5.15e-01 -2.97e-02 7.78e-01
Translocation of ZAP-70 to Immunological synapse 19 5.15e-01 -8.62e-02 7.78e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.16e-01 9.09e-02 7.78e-01
Defective CFTR causes cystic fibrosis 58 5.19e-01 4.90e-02 7.79e-01
Resolution of Abasic Sites (AP sites) 38 5.19e-01 6.04e-02 7.79e-01
Chaperonin-mediated protein folding 80 5.20e-01 4.17e-02 7.79e-01
Selective autophagy 59 5.20e-01 -4.84e-02 7.79e-01
Activation of G protein gated Potassium channels 19 5.20e-01 -8.52e-02 7.79e-01
G protein gated Potassium channels 19 5.20e-01 -8.52e-02 7.79e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 5.20e-01 -8.52e-02 7.79e-01
Clathrin-mediated endocytosis 132 5.21e-01 -3.24e-02 7.79e-01
Glycolysis 66 5.22e-01 4.56e-02 7.79e-01
Hyaluronan metabolism 16 5.23e-01 -9.22e-02 7.80e-01
Macroautophagy 112 5.25e-01 -3.47e-02 7.83e-01
MAPK1/MAPK3 signaling 248 5.26e-01 2.34e-02 7.83e-01
Signaling by MET 64 5.27e-01 -4.57e-02 7.83e-01
Signaling by PDGFRA extracellular domain mutants 12 5.28e-01 1.05e-01 7.83e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 5.28e-01 1.05e-01 7.83e-01
RHO GTPases activate PAKs 21 5.28e-01 -7.95e-02 7.83e-01
Spry regulation of FGF signaling 16 5.31e-01 -9.04e-02 7.87e-01
Netrin-1 signaling 42 5.32e-01 -5.58e-02 7.87e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 5.35e-01 -4.07e-02 7.88e-01
Regulation of BACH1 activity 11 5.35e-01 1.08e-01 7.88e-01
RAC2 GTPase cycle 86 5.35e-01 3.87e-02 7.88e-01
SHC1 events in EGFR signaling 13 5.36e-01 9.92e-02 7.88e-01
IRAK1 recruits IKK complex 10 5.36e-01 1.13e-01 7.88e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 5.36e-01 1.13e-01 7.88e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 89 5.37e-01 3.79e-02 7.88e-01
E3 ubiquitin ligases ubiquitinate target proteins 48 5.42e-01 5.08e-02 7.95e-01
Regulation of TP53 Activity through Methylation 19 5.43e-01 -8.07e-02 7.95e-01
Phosphorylation of CD3 and TCR zeta chains 22 5.43e-01 -7.49e-02 7.95e-01
mRNA 3’-end processing 56 5.44e-01 4.69e-02 7.95e-01
Signaling by FGFR2 62 5.44e-01 4.46e-02 7.95e-01
Interleukin-2 signaling 11 5.45e-01 1.05e-01 7.95e-01
Degradation of cysteine and homocysteine 13 5.45e-01 -9.70e-02 7.95e-01
O-linked glycosylation 93 5.49e-01 3.60e-02 7.99e-01
Signaling by FLT3 ITD and TKD mutants 15 5.49e-01 8.93e-02 7.99e-01
Formation of Incision Complex in GG-NER 43 5.50e-01 5.27e-02 7.99e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 5.50e-01 -1.09e-01 7.99e-01
Signaling by NTRK3 (TRKC) 17 5.53e-01 8.32e-02 8.02e-01
Late endosomal microautophagy 30 5.55e-01 -6.23e-02 8.04e-01
Glutamate and glutamine metabolism 13 5.56e-01 9.42e-02 8.06e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 5.60e-01 7.35e-02 8.11e-01
RHO GTPases activate IQGAPs 10 5.63e-01 1.06e-01 8.14e-01
Regulation of TP53 Activity through Association with Co-factors 12 5.67e-01 -9.55e-02 8.17e-01
SUMOylation of chromatin organization proteins 57 5.67e-01 4.38e-02 8.17e-01
HCMV Early Events 68 5.67e-01 4.01e-02 8.17e-01
ABC-family proteins mediated transport 92 5.68e-01 -3.45e-02 8.17e-01
IRAK2 mediated activation of TAK1 complex 10 5.68e-01 1.04e-01 8.17e-01
RHOF GTPase cycle 40 5.70e-01 5.19e-02 8.19e-01
Signaling by WNT in cancer 28 5.70e-01 6.20e-02 8.19e-01
Platelet homeostasis 72 5.71e-01 -3.86e-02 8.19e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 5.73e-01 -8.14e-02 8.21e-01
ISG15 antiviral mechanism 72 5.74e-01 3.83e-02 8.22e-01
Signaling by ERBB2 in Cancer 24 5.74e-01 -6.62e-02 8.22e-01
CDC42 GTPase cycle 148 5.75e-01 2.67e-02 8.22e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 5.77e-01 -5.30e-02 8.23e-01
Erythropoietin activates RAS 13 5.77e-01 8.93e-02 8.23e-01
Signaling by FGFR4 33 5.79e-01 5.58e-02 8.25e-01
Telomere C-strand (Lagging Strand) Synthesis 34 5.80e-01 5.48e-02 8.26e-01
Glycogen breakdown (glycogenolysis) 15 5.81e-01 8.23e-02 8.26e-01
G-protein beta:gamma signalling 28 5.83e-01 -6.00e-02 8.27e-01
Stimuli-sensing channels 72 5.83e-01 3.74e-02 8.27e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 5.85e-01 7.88e-02 8.28e-01
TRP channels 17 5.87e-01 -7.61e-02 8.28e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 5.87e-01 3.37e-02 8.28e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 5.87e-01 -9.91e-02 8.28e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 39 5.88e-01 -5.02e-02 8.28e-01
Metabolism of cofactors 19 5.88e-01 7.19e-02 8.28e-01
G alpha (12/13) signalling events 73 5.88e-01 -3.67e-02 8.28e-01
Cell recruitment (pro-inflammatory response) 24 5.89e-01 -6.38e-02 8.28e-01
Purinergic signaling in leishmaniasis infection 24 5.89e-01 -6.38e-02 8.28e-01
Formation of Fibrin Clot (Clotting Cascade) 25 5.90e-01 -6.22e-02 8.28e-01
Activation of SMO 16 5.91e-01 -7.77e-02 8.28e-01
Interleukin-17 signaling 67 5.92e-01 3.79e-02 8.28e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 5.92e-01 7.11e-02 8.28e-01
Signaling by KIT in disease 20 5.92e-01 -6.92e-02 8.28e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 5.92e-01 -6.92e-02 8.28e-01
Non-integrin membrane-ECM interactions 41 5.93e-01 -4.83e-02 8.28e-01
Protein folding 86 5.93e-01 3.33e-02 8.28e-01
DAG and IP3 signaling 39 5.94e-01 -4.94e-02 8.28e-01
Asparagine N-linked glycosylation 272 5.94e-01 -1.88e-02 8.28e-01
Pregnenolone biosynthesis 10 5.95e-01 9.70e-02 8.29e-01
Glycosphingolipid metabolism 37 5.98e-01 -5.01e-02 8.31e-01
RND3 GTPase cycle 38 5.99e-01 4.93e-02 8.32e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 125 6.00e-01 2.72e-02 8.33e-01
Acyl chain remodelling of PS 15 6.02e-01 -7.77e-02 8.35e-01
Removal of the Flap Intermediate 14 6.03e-01 -8.04e-02 8.35e-01
RHOC GTPase cycle 71 6.05e-01 3.56e-02 8.36e-01
Recycling pathway of L1 27 6.05e-01 -5.76e-02 8.36e-01
MyD88 dependent cascade initiated on endosome 90 6.08e-01 3.13e-02 8.39e-01
Integrin signaling 24 6.08e-01 -6.04e-02 8.39e-01
Deadenylation-dependent mRNA decay 53 6.09e-01 4.06e-02 8.39e-01
FOXO-mediated transcription of cell death genes 15 6.12e-01 -7.56e-02 8.42e-01
Mitochondrial translation 96 6.12e-01 -2.99e-02 8.42e-01
MET receptor recycling 10 6.17e-01 -9.13e-02 8.48e-01
Interferon alpha/beta signaling 56 6.19e-01 -3.84e-02 8.50e-01
PECAM1 interactions 12 6.21e-01 8.25e-02 8.51e-01
Cytosolic tRNA aminoacylation 24 6.21e-01 5.82e-02 8.51e-01
G beta:gamma signalling through CDC42 16 6.23e-01 -7.09e-02 8.51e-01
Regulation of TP53 Activity through Acetylation 29 6.26e-01 5.23e-02 8.51e-01
Respiratory electron transport 103 6.26e-01 2.78e-02 8.51e-01
Serotonin Neurotransmitter Release Cycle 16 6.27e-01 -7.03e-02 8.51e-01
Calnexin/calreticulin cycle 26 6.28e-01 -5.48e-02 8.51e-01
tRNA modification in the nucleus and cytosol 43 6.30e-01 -4.25e-02 8.51e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 11 6.31e-01 -8.37e-02 8.51e-01
Diseases of hemostasis 11 6.31e-01 -8.37e-02 8.51e-01
HCMV Late Events 63 6.32e-01 -3.49e-02 8.51e-01
Free fatty acids regulate insulin secretion 10 6.32e-01 -8.74e-02 8.51e-01
CD209 (DC-SIGN) signaling 20 6.32e-01 -6.18e-02 8.51e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 6.33e-01 -6.91e-02 8.51e-01
RNA Polymerase III Transcription Initiation 36 6.33e-01 -4.60e-02 8.51e-01
Semaphorin interactions 63 6.33e-01 3.48e-02 8.51e-01
TNFR1-induced NFkappaB signaling pathway 26 6.33e-01 5.41e-02 8.51e-01
G-protein mediated events 51 6.33e-01 -3.86e-02 8.51e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 6.34e-01 7.95e-02 8.51e-01
TICAM1-dependent activation of IRF3/IRF7 12 6.34e-01 7.93e-02 8.51e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 6.34e-01 -5.29e-02 8.51e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 45 6.35e-01 4.09e-02 8.51e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 11 6.36e-01 -8.23e-02 8.51e-01
Signaling by high-kinase activity BRAF mutants 31 6.37e-01 -4.89e-02 8.51e-01
FRS-mediated FGFR1 signaling 16 6.38e-01 6.79e-02 8.51e-01
RHO GTPases Activate WASPs and WAVEs 36 6.38e-01 -4.53e-02 8.51e-01
RAF/MAP kinase cascade 242 6.39e-01 1.75e-02 8.51e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.39e-01 -3.39e-02 8.51e-01
MAP2K and MAPK activation 35 6.40e-01 -4.56e-02 8.51e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 6.40e-01 -3.58e-02 8.51e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 6.40e-01 -3.58e-02 8.51e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 6.40e-01 -3.58e-02 8.51e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 6.40e-01 -3.58e-02 8.51e-01
Signaling by NOTCH1 in Cancer 57 6.40e-01 -3.58e-02 8.51e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 15 6.41e-01 -6.96e-02 8.51e-01
Downstream signaling of activated FGFR1 23 6.44e-01 5.56e-02 8.55e-01
IGF1R signaling cascade 40 6.45e-01 4.21e-02 8.55e-01
Citric acid cycle (TCA cycle) 22 6.49e-01 5.61e-02 8.60e-01
Formation of TC-NER Pre-Incision Complex 53 6.52e-01 -3.58e-02 8.63e-01
Platelet Aggregation (Plug Formation) 31 6.53e-01 -4.67e-02 8.63e-01
Mitochondrial tRNA aminoacylation 21 6.55e-01 -5.64e-02 8.64e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 6.55e-01 -6.66e-02 8.64e-01
Interactions of Rev with host cellular proteins 37 6.55e-01 4.24e-02 8.64e-01
SHC1 events in ERBB4 signaling 12 6.56e-01 -7.43e-02 8.64e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 6.56e-01 2.81e-02 8.64e-01
Activation of AMPK downstream of NMDARs 10 6.57e-01 8.12e-02 8.64e-01
PIWI-interacting RNA (piRNA) biogenesis 22 6.58e-01 5.45e-02 8.64e-01
Chondroitin sulfate biosynthesis 16 6.58e-01 -6.39e-02 8.64e-01
Cell junction organization 65 6.59e-01 3.17e-02 8.64e-01
Extracellular matrix organization 259 6.60e-01 -1.59e-02 8.64e-01
Collagen biosynthesis and modifying enzymes 61 6.60e-01 -3.26e-02 8.64e-01
Translesion synthesis by REV1 16 6.62e-01 -6.31e-02 8.65e-01
IRS-mediated signalling 36 6.63e-01 4.20e-02 8.65e-01
Repression of WNT target genes 14 6.64e-01 -6.71e-02 8.65e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 91 6.64e-01 2.64e-02 8.65e-01
Unfolded Protein Response (UPR) 91 6.64e-01 2.63e-02 8.65e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 34 6.65e-01 -4.29e-02 8.65e-01
Beta-oxidation of very long chain fatty acids 10 6.65e-01 -7.91e-02 8.65e-01
Signaling by ERBB2 48 6.65e-01 -3.61e-02 8.65e-01
Prolactin receptor signaling 11 6.67e-01 -7.50e-02 8.66e-01
Downstream signal transduction 29 6.70e-01 -4.57e-02 8.70e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.72e-01 -4.62e-02 8.71e-01
Generation of second messenger molecules 33 6.73e-01 -4.24e-02 8.71e-01
Activation of gene expression by SREBF (SREBP) 42 6.73e-01 3.76e-02 8.71e-01
Presynaptic function of Kainate receptors 17 6.74e-01 -5.90e-02 8.71e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 6.75e-01 6.26e-02 8.71e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 6.75e-01 6.26e-02 8.71e-01
Synthesis of IP3 and IP4 in the cytosol 24 6.76e-01 4.93e-02 8.71e-01
FLT3 signaling in disease 27 6.77e-01 4.64e-02 8.72e-01
Phospholipase C-mediated cascade; FGFR2 10 6.78e-01 7.58e-02 8.73e-01
Toll Like Receptor 9 (TLR9) Cascade 94 6.80e-01 2.46e-02 8.74e-01
DARPP-32 events 23 6.80e-01 -4.96e-02 8.74e-01
Intracellular signaling by second messengers 284 6.83e-01 1.41e-02 8.77e-01
Detoxification of Reactive Oxygen Species 33 6.84e-01 -4.10e-02 8.77e-01
TNFR1-induced proapoptotic signaling 13 6.85e-01 6.51e-02 8.77e-01
RHO GTPases Activate ROCKs 19 6.86e-01 5.36e-02 8.78e-01
Miscellaneous transport and binding events 22 6.87e-01 4.97e-02 8.78e-01
Purine catabolism 13 6.89e-01 6.40e-02 8.81e-01
Lewis blood group biosynthesis 11 6.91e-01 6.91e-02 8.83e-01
Metabolism of water-soluble vitamins and cofactors 109 6.92e-01 -2.19e-02 8.83e-01
Viral Messenger RNA Synthesis 44 6.93e-01 -3.45e-02 8.83e-01
PINK1-PRKN Mediated Mitophagy 21 6.93e-01 -4.97e-02 8.83e-01
Hh mutants abrogate ligand secretion 55 6.94e-01 3.06e-02 8.84e-01
mRNA Splicing - Minor Pathway 52 6.96e-01 -3.13e-02 8.85e-01
SUMOylation of ubiquitinylation proteins 39 6.97e-01 -3.60e-02 8.86e-01
Metabolism of proteins 1687 6.98e-01 5.72e-03 8.86e-01
Diseases associated with the TLR signaling cascade 27 7.00e-01 4.29e-02 8.86e-01
Diseases of Immune System 27 7.00e-01 4.29e-02 8.86e-01
Metabolic disorders of biological oxidation enzymes 24 7.00e-01 -4.54e-02 8.86e-01
Chemokine receptors bind chemokines 40 7.01e-01 3.51e-02 8.86e-01
Intrinsic Pathway of Fibrin Clot Formation 15 7.01e-01 -5.72e-02 8.86e-01
AKT phosphorylates targets in the cytosol 14 7.02e-01 5.91e-02 8.86e-01
Killing mechanisms 10 7.04e-01 -6.94e-02 8.86e-01
WNT5:FZD7-mediated leishmania damping 10 7.04e-01 -6.94e-02 8.86e-01
mTORC1-mediated signalling 24 7.04e-01 4.48e-02 8.86e-01
Glycogen synthesis 15 7.05e-01 -5.65e-02 8.86e-01
Vpr-mediated nuclear import of PICs 34 7.05e-01 -3.75e-02 8.86e-01
Deactivation of the beta-catenin transactivating complex 39 7.08e-01 3.46e-02 8.89e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 7.10e-01 5.37e-02 8.89e-01
Recognition of DNA damage by PCNA-containing replication complex 30 7.10e-01 -3.92e-02 8.89e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 7.11e-01 5.73e-02 8.89e-01
ATF6 (ATF6-alpha) activates chaperones 12 7.11e-01 6.18e-02 8.89e-01
RHOB GTPase cycle 67 7.14e-01 2.59e-02 8.89e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 33 7.14e-01 -3.69e-02 8.89e-01
RHO GTPases activate CIT 19 7.14e-01 -4.85e-02 8.89e-01
GRB2 events in EGFR signaling 12 7.15e-01 6.09e-02 8.89e-01
Nuclear events stimulated by ALK signaling in cancer 19 7.16e-01 4.83e-02 8.89e-01
Nucleotide Excision Repair 110 7.16e-01 -2.01e-02 8.89e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 7.17e-01 3.89e-02 8.89e-01
Endosomal/Vacuolar pathway 11 7.18e-01 6.28e-02 8.89e-01
SARS-CoV-2 Infection 68 7.19e-01 -2.53e-02 8.89e-01
SUMOylation of transcription cofactors 44 7.21e-01 -3.12e-02 8.89e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 7.21e-01 -3.89e-02 8.89e-01
Removal of the Flap Intermediate from the C-strand 17 7.22e-01 -4.98e-02 8.89e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 41 7.22e-01 3.21e-02 8.89e-01
DAP12 signaling 28 7.22e-01 3.88e-02 8.89e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 7.23e-01 -3.24e-02 8.89e-01
Signaling by RAS mutants 40 7.23e-01 -3.24e-02 8.89e-01
Signaling by moderate kinase activity BRAF mutants 40 7.23e-01 -3.24e-02 8.89e-01
Signaling downstream of RAS mutants 40 7.23e-01 -3.24e-02 8.89e-01
tRNA processing in the nucleus 59 7.24e-01 -2.66e-02 8.89e-01
MAPK3 (ERK1) activation 10 7.25e-01 6.43e-02 8.89e-01
Nephrin family interactions 20 7.25e-01 -4.54e-02 8.89e-01
Metabolism of lipids 622 7.26e-01 8.27e-03 8.89e-01
NRAGE signals death through JNK 57 7.26e-01 -2.69e-02 8.89e-01
Circadian Clock 68 7.26e-01 2.46e-02 8.89e-01
RND2 GTPase cycle 39 7.26e-01 -3.24e-02 8.89e-01
Triglyceride metabolism 25 7.26e-01 -4.04e-02 8.89e-01
Incretin synthesis, secretion, and inactivation 13 7.28e-01 -5.58e-02 8.89e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 7.28e-01 -5.58e-02 8.89e-01
Defects in cobalamin (B12) metabolism 12 7.30e-01 -5.76e-02 8.90e-01
Acetylcholine Neurotransmitter Release Cycle 12 7.31e-01 5.74e-02 8.90e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 7.31e-01 -4.56e-02 8.90e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 7.31e-01 -4.23e-02 8.90e-01
Signaling by TGFB family members 97 7.32e-01 2.01e-02 8.90e-01
MET activates RAP1 and RAC1 11 7.33e-01 -5.94e-02 8.90e-01
Signaling by Non-Receptor Tyrosine Kinases 51 7.34e-01 -2.75e-02 8.90e-01
Signaling by PTK6 51 7.34e-01 -2.75e-02 8.90e-01
Smooth Muscle Contraction 33 7.34e-01 -3.42e-02 8.90e-01
PLC beta mediated events 47 7.35e-01 -2.85e-02 8.91e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 7.36e-01 -5.87e-02 8.91e-01
FGFR1 mutant receptor activation 26 7.37e-01 3.80e-02 8.91e-01
HIV Infection 224 7.38e-01 1.30e-02 8.91e-01
RHOA GTPase cycle 145 7.42e-01 1.59e-02 8.96e-01
Cellular response to chemical stress 151 7.42e-01 1.55e-02 8.96e-01
Zinc transporters 12 7.44e-01 5.45e-02 8.96e-01
Josephin domain DUBs 10 7.44e-01 -5.96e-02 8.96e-01
DNA Damage Recognition in GG-NER 38 7.45e-01 -3.05e-02 8.96e-01
Nuclear import of Rev protein 34 7.48e-01 3.18e-02 9.00e-01
CRMPs in Sema3A signaling 15 7.51e-01 -4.72e-02 9.01e-01
Signaling by VEGF 103 7.51e-01 -1.81e-02 9.01e-01
Processing and activation of SUMO 10 7.52e-01 5.77e-02 9.01e-01
Interaction between L1 and Ankyrins 24 7.52e-01 3.73e-02 9.01e-01
Transport to the Golgi and subsequent modification 158 7.53e-01 1.45e-02 9.02e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 7.54e-01 3.54e-02 9.03e-01
IRS-related events triggered by IGF1R 39 7.55e-01 2.89e-02 9.03e-01
Termination of translesion DNA synthesis 31 7.57e-01 -3.22e-02 9.04e-01
ER to Golgi Anterograde Transport 132 7.59e-01 1.55e-02 9.06e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 11 7.62e-01 -5.28e-02 9.09e-01
Mitochondrial calcium ion transport 22 7.63e-01 3.72e-02 9.09e-01
Aflatoxin activation and detoxification 12 7.63e-01 5.02e-02 9.09e-01
Infection with Mycobacterium tuberculosis 27 7.64e-01 -3.34e-02 9.09e-01
Uptake and actions of bacterial toxins 25 7.65e-01 -3.45e-02 9.09e-01
IRF3-mediated induction of type I IFN 12 7.66e-01 4.96e-02 9.09e-01
Bile acid and bile salt metabolism 31 7.66e-01 -3.08e-02 9.09e-01
SARS-CoV Infections 148 7.68e-01 1.40e-02 9.11e-01
Amino acid transport across the plasma membrane 23 7.70e-01 3.53e-02 9.11e-01
Striated Muscle Contraction 30 7.70e-01 3.08e-02 9.11e-01
Sensory perception of taste 21 7.70e-01 -3.68e-02 9.11e-01
Tie2 Signaling 16 7.71e-01 4.20e-02 9.11e-01
HIV Life Cycle 145 7.72e-01 1.40e-02 9.11e-01
FGFR2 mutant receptor activation 25 7.73e-01 3.33e-02 9.12e-01
Translation of Structural Proteins 29 7.75e-01 -3.07e-02 9.14e-01
Polymerase switching on the C-strand of the telomere 26 7.80e-01 3.16e-02 9.16e-01
RNA Polymerase I Transcription Termination 30 7.80e-01 -2.94e-02 9.16e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 7.81e-01 -3.22e-02 9.16e-01
RND1 GTPase cycle 40 7.82e-01 -2.53e-02 9.16e-01
Aggrephagy 21 7.82e-01 3.49e-02 9.16e-01
MET activates RAS signaling 11 7.82e-01 -4.82e-02 9.16e-01
RHOV GTPase cycle 35 7.82e-01 -2.70e-02 9.16e-01
ERKs are inactivated 13 7.82e-01 -4.42e-02 9.16e-01
VEGFR2 mediated vascular permeability 27 7.83e-01 -3.07e-02 9.16e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 26 7.83e-01 3.12e-02 9.16e-01
G alpha (z) signalling events 41 7.85e-01 2.46e-02 9.16e-01
MTOR signalling 41 7.85e-01 2.46e-02 9.16e-01
HCMV Infection 91 7.86e-01 -1.65e-02 9.16e-01
Synthesis of PIPs at the Golgi membrane 15 7.86e-01 4.06e-02 9.16e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 32 7.88e-01 2.75e-02 9.17e-01
RNA Polymerase I Transcription Initiation 47 7.88e-01 -2.27e-02 9.17e-01
PI-3K cascade:FGFR1 14 7.88e-01 4.15e-02 9.17e-01
Sema4D in semaphorin signaling 24 7.89e-01 3.15e-02 9.17e-01
Biotin transport and metabolism 11 7.90e-01 4.64e-02 9.17e-01
RHOG GTPase cycle 72 7.93e-01 1.79e-02 9.20e-01
Negative regulation of FGFR1 signaling 26 7.95e-01 -2.94e-02 9.21e-01
Collagen chain trimerization 39 7.95e-01 2.40e-02 9.21e-01
TBC/RABGAPs 45 7.99e-01 2.20e-02 9.24e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 23 8.00e-01 3.05e-02 9.25e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 8.00e-01 -2.26e-02 9.25e-01
Rev-mediated nuclear export of HIV RNA 35 8.01e-01 2.46e-02 9.25e-01
RNA Polymerase III Chain Elongation 18 8.02e-01 -3.42e-02 9.25e-01
Cristae formation 31 8.03e-01 2.59e-02 9.25e-01
WNT ligand biogenesis and trafficking 18 8.03e-01 -3.39e-02 9.25e-01
Pyrimidine salvage 10 8.04e-01 -4.52e-02 9.25e-01
Sulfur amino acid metabolism 25 8.05e-01 -2.86e-02 9.25e-01
Synthesis of bile acids and bile salts 27 8.09e-01 2.69e-02 9.27e-01
PI Metabolism 79 8.10e-01 1.56e-02 9.27e-01
Signaling by PDGF 50 8.11e-01 -1.96e-02 9.27e-01
Intra-Golgi traffic 42 8.11e-01 2.13e-02 9.27e-01
p75 NTR receptor-mediated signalling 93 8.12e-01 1.43e-02 9.27e-01
Cell death signalling via NRAGE, NRIF and NADE 74 8.12e-01 -1.60e-02 9.27e-01
Glycerophospholipid biosynthesis 107 8.13e-01 -1.33e-02 9.27e-01
RHOJ GTPase cycle 54 8.13e-01 1.86e-02 9.27e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 17 8.13e-01 3.31e-02 9.27e-01
Host Interactions of HIV factors 128 8.14e-01 1.20e-02 9.27e-01
Sphingolipid metabolism 75 8.15e-01 -1.56e-02 9.27e-01
Cytosolic sulfonation of small molecules 19 8.16e-01 -3.09e-02 9.27e-01
NF-kB is activated and signals survival 13 8.17e-01 3.70e-02 9.27e-01
PPARA activates gene expression 105 8.18e-01 -1.30e-02 9.27e-01
FOXO-mediated transcription 59 8.18e-01 1.74e-02 9.27e-01
Response of Mtb to phagocytosis 23 8.18e-01 -2.77e-02 9.27e-01
Regulation of lipid metabolism by PPARalpha 107 8.18e-01 -1.29e-02 9.27e-01
ABC transporter disorders 68 8.18e-01 -1.61e-02 9.27e-01
Glycogen metabolism 26 8.20e-01 -2.58e-02 9.28e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 8.20e-01 -3.64e-02 9.28e-01
Regulation of localization of FOXO transcription factors 12 8.21e-01 3.77e-02 9.28e-01
TRAF3-dependent IRF activation pathway 14 8.22e-01 -3.48e-02 9.28e-01
Glutathione synthesis and recycling 11 8.22e-01 3.93e-02 9.28e-01
Glyoxylate metabolism and glycine degradation 24 8.22e-01 2.65e-02 9.28e-01
Long-term potentiation 18 8.27e-01 -2.98e-02 9.31e-01
Interleukin-27 signaling 10 8.27e-01 -3.99e-02 9.31e-01
Synthesis of substrates in N-glycan biosythesis 58 8.27e-01 1.66e-02 9.31e-01
Signaling by NOTCH2 32 8.28e-01 2.23e-02 9.31e-01
Branched-chain amino acid catabolism 21 8.28e-01 -2.74e-02 9.31e-01
Cell-Cell communication 95 8.31e-01 -1.26e-02 9.31e-01
SARS-CoV-1 Infection 47 8.32e-01 -1.79e-02 9.31e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 8.32e-01 -1.89e-02 9.31e-01
HIV Transcription Elongation 42 8.32e-01 -1.89e-02 9.31e-01
Tat-mediated elongation of the HIV-1 transcript 42 8.32e-01 -1.89e-02 9.31e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 13 8.32e-01 -3.39e-02 9.31e-01
Keratan sulfate degradation 12 8.34e-01 3.49e-02 9.32e-01
TNFs bind their physiological receptors 23 8.35e-01 2.51e-02 9.32e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 8.35e-01 -1.81e-02 9.32e-01
Metabolism of steroid hormones 24 8.36e-01 -2.45e-02 9.32e-01
Frs2-mediated activation 12 8.37e-01 -3.43e-02 9.33e-01
SUMOylation of RNA binding proteins 47 8.39e-01 1.71e-02 9.33e-01
Elevation of cytosolic Ca2+ levels 12 8.39e-01 -3.38e-02 9.33e-01
Blood group systems biosynthesis 15 8.39e-01 3.02e-02 9.33e-01
NRIF signals cell death from the nucleus 16 8.40e-01 -2.91e-02 9.33e-01
Synthesis of pyrophosphates in the cytosol 10 8.41e-01 -3.67e-02 9.33e-01
Transcription of the HIV genome 67 8.41e-01 1.41e-02 9.33e-01
Fatty acid metabolism 146 8.43e-01 9.49e-03 9.33e-01
Collagen formation 83 8.43e-01 1.26e-02 9.33e-01
RNA Polymerase II Pre-transcription Events 78 8.43e-01 1.29e-02 9.33e-01
Biosynthesis of DHA-derived SPMs 11 8.45e-01 3.40e-02 9.35e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 8.47e-01 3.37e-02 9.35e-01
Sphingolipid de novo biosynthesis 38 8.47e-01 1.81e-02 9.35e-01
FGFR2 ligand binding and activation 11 8.48e-01 -3.35e-02 9.35e-01
Interleukin-15 signaling 14 8.48e-01 2.95e-02 9.35e-01
Maturation of nucleoprotein 11 8.49e-01 -3.32e-02 9.35e-01
AKT phosphorylates targets in the nucleus 10 8.50e-01 3.45e-02 9.36e-01
Export of Viral Ribonucleoproteins from Nucleus 33 8.52e-01 -1.88e-02 9.37e-01
Fanconi Anemia Pathway 35 8.55e-01 1.78e-02 9.40e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 8.56e-01 3.16e-02 9.40e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 8.58e-01 3.27e-02 9.41e-01
G alpha (q) signalling events 146 8.58e-01 8.59e-03 9.41e-01
SUMOylation of transcription factors 17 8.59e-01 -2.49e-02 9.41e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 8.62e-01 2.60e-02 9.44e-01
Mitochondrial biogenesis 92 8.63e-01 -1.04e-02 9.44e-01
Mucopolysaccharidoses 11 8.64e-01 -2.99e-02 9.44e-01
Post NMDA receptor activation events 55 8.65e-01 -1.32e-02 9.45e-01
Golgi Associated Vesicle Biogenesis 55 8.65e-01 -1.32e-02 9.45e-01
Negative regulation of FGFR2 signaling 26 8.67e-01 -1.89e-02 9.46e-01
Other interleukin signaling 21 8.70e-01 2.06e-02 9.47e-01
Tight junction interactions 17 8.71e-01 -2.28e-02 9.47e-01
Heme signaling 44 8.71e-01 -1.42e-02 9.47e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 8.72e-01 -1.87e-02 9.47e-01
Negative regulators of DDX58/IFIH1 signaling 35 8.72e-01 1.58e-02 9.47e-01
Vesicle-mediated transport 635 8.73e-01 -3.73e-03 9.48e-01
Negative regulation of FGFR3 signaling 24 8.73e-01 1.88e-02 9.48e-01
Norepinephrine Neurotransmitter Release Cycle 15 8.77e-01 -2.31e-02 9.51e-01
Interactions of Vpr with host cellular proteins 37 8.82e-01 -1.41e-02 9.51e-01
Signaling by NTRK2 (TRKB) 23 8.82e-01 -1.79e-02 9.51e-01
Interleukin receptor SHC signaling 22 8.82e-01 1.82e-02 9.51e-01
ERK/MAPK targets 22 8.83e-01 -1.82e-02 9.51e-01
Pre-NOTCH Processing in Golgi 18 8.83e-01 -2.00e-02 9.51e-01
eNOS activation 11 8.84e-01 -2.55e-02 9.51e-01
Disorders of Developmental Biology 13 8.84e-01 2.33e-02 9.51e-01
Disorders of Nervous System Development 13 8.84e-01 2.33e-02 9.51e-01
Loss of function of MECP2 in Rett syndrome 13 8.84e-01 2.33e-02 9.51e-01
Pervasive developmental disorders 13 8.84e-01 2.33e-02 9.51e-01
Activation of kainate receptors upon glutamate binding 24 8.85e-01 1.71e-02 9.51e-01
Acyl chain remodelling of PG 11 8.86e-01 2.49e-02 9.52e-01
Processive synthesis on the C-strand of the telomere 19 8.87e-01 1.89e-02 9.52e-01
Interleukin-35 Signalling 11 8.87e-01 -2.47e-02 9.52e-01
Regulation of IFNG signaling 13 8.88e-01 2.25e-02 9.52e-01
Metabolism of folate and pterines 17 8.89e-01 1.96e-02 9.52e-01
Glutamate Neurotransmitter Release Cycle 22 8.90e-01 1.70e-02 9.53e-01
Defects in vitamin and cofactor metabolism 20 8.91e-01 1.77e-02 9.53e-01
Tryptophan catabolism 11 8.92e-01 2.38e-02 9.53e-01
RHOQ GTPase cycle 58 8.95e-01 1.00e-02 9.54e-01
PCP/CE pathway 88 8.96e-01 -8.07e-03 9.54e-01
Negative regulation of FGFR4 signaling 23 8.96e-01 -1.57e-02 9.54e-01
Prolonged ERK activation events 14 8.96e-01 2.01e-02 9.54e-01
Processive synthesis on the lagging strand 15 8.96e-01 -1.94e-02 9.54e-01
DNA Damage Bypass 46 8.97e-01 -1.10e-02 9.54e-01
Transcriptional activation of mitochondrial biogenesis 53 8.97e-01 1.02e-02 9.54e-01
Heme biosynthesis 13 9.02e-01 1.98e-02 9.58e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 9.03e-01 -1.08e-02 9.58e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 9.04e-01 1.93e-02 9.59e-01
Synthesis of PA 31 9.05e-01 -1.24e-02 9.59e-01
NS1 Mediated Effects on Host Pathways 40 9.10e-01 1.04e-02 9.63e-01
RHO GTPases Activate NADPH Oxidases 21 9.10e-01 -1.42e-02 9.63e-01
RHOBTB3 ATPase cycle 10 9.15e-01 -1.96e-02 9.68e-01
Signaling by Hedgehog 130 9.16e-01 -5.38e-03 9.68e-01
Translesion synthesis by POLK 17 9.17e-01 -1.46e-02 9.68e-01
Formation of RNA Pol II elongation complex 57 9.18e-01 7.92e-03 9.68e-01
RNA Polymerase II Transcription Elongation 57 9.18e-01 7.92e-03 9.68e-01
Transport of the SLBP Dependant Mature mRNA 36 9.18e-01 9.88e-03 9.68e-01
Late Phase of HIV Life Cycle 132 9.19e-01 -5.11e-03 9.68e-01
Asymmetric localization of PCP proteins 62 9.20e-01 -7.33e-03 9.69e-01
Nucleotide biosynthesis 12 9.21e-01 -1.65e-02 9.69e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 9.22e-01 -1.00e-02 9.69e-01
Signaling by FGFR1 42 9.24e-01 8.56e-03 9.70e-01
Hedgehog ligand biogenesis 60 9.25e-01 -7.02e-03 9.71e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 9.27e-01 1.07e-02 9.72e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 9.29e-01 -1.34e-02 9.73e-01
Leading Strand Synthesis 14 9.31e-01 1.34e-02 9.74e-01
Polymerase switching 14 9.31e-01 1.34e-02 9.74e-01
Lagging Strand Synthesis 20 9.31e-01 1.11e-02 9.74e-01
Notch-HLH transcription pathway 28 9.34e-01 -9.09e-03 9.75e-01
Glucose metabolism 83 9.34e-01 -5.24e-03 9.75e-01
Signaling by NOTCH3 46 9.35e-01 -6.94e-03 9.75e-01
Cytosolic iron-sulfur cluster assembly 13 9.35e-01 -1.30e-02 9.75e-01
PI3K Cascade 32 9.39e-01 -7.87e-03 9.78e-01
Signaling by BMP 24 9.43e-01 -8.49e-03 9.81e-01
Cytosolic sensors of pathogen-associated DNA 63 9.44e-01 5.09e-03 9.81e-01
STING mediated induction of host immune responses 15 9.44e-01 1.04e-02 9.81e-01
Signaling by RAF1 mutants 36 9.45e-01 6.61e-03 9.81e-01
Processing of Capped Intronless Pre-mRNA 28 9.46e-01 -7.41e-03 9.81e-01
ER Quality Control Compartment (ERQC) 21 9.47e-01 -8.44e-03 9.81e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 18 9.47e-01 -9.09e-03 9.81e-01
Biosynthesis of specialized proresolving mediators (SPMs) 13 9.47e-01 -1.07e-02 9.81e-01
TRAF6 mediated NF-kB activation 25 9.48e-01 -7.48e-03 9.82e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 68 9.49e-01 4.45e-03 9.82e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 9.50e-01 -6.37e-03 9.82e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 9.50e-01 -6.37e-03 9.82e-01
Gap junction degradation 10 9.53e-01 1.08e-02 9.83e-01
Regulation of TLR by endogenous ligand 15 9.54e-01 -8.60e-03 9.84e-01
NOTCH3 Intracellular Domain Regulates Transcription 22 9.55e-01 -6.95e-03 9.84e-01
Translesion synthesis by POLI 17 9.60e-01 -7.10e-03 9.87e-01
Mitochondrial protein import 64 9.60e-01 3.64e-03 9.87e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 9.60e-01 -8.33e-03 9.87e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 9.61e-01 -5.83e-03 9.87e-01
Signaling by EGFR 48 9.61e-01 -4.08e-03 9.87e-01
Phospholipid metabolism 185 9.62e-01 -2.02e-03 9.87e-01
trans-Golgi Network Vesicle Budding 70 9.62e-01 3.26e-03 9.87e-01
Signaling by Nuclear Receptors 224 9.63e-01 1.82e-03 9.87e-01
Processing of SMDT1 15 9.64e-01 6.67e-03 9.87e-01
Translesion Synthesis by POLH 18 9.65e-01 -6.00e-03 9.87e-01
VEGFA-VEGFR2 Pathway 94 9.66e-01 2.52e-03 9.88e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 9.67e-01 5.89e-03 9.89e-01
Transport of the SLBP independent Mature mRNA 35 9.70e-01 -3.66e-03 9.90e-01
Dopamine Neurotransmitter Release Cycle 21 9.70e-01 4.70e-03 9.90e-01
Growth hormone receptor signaling 20 9.71e-01 4.63e-03 9.90e-01
L1CAM interactions 90 9.74e-01 -2.00e-03 9.90e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 9.74e-01 3.34e-03 9.90e-01
SUMOylation of SUMOylation proteins 35 9.74e-01 -3.15e-03 9.90e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 9.74e-01 2.17e-03 9.90e-01
Dual Incision in GG-NER 41 9.75e-01 2.86e-03 9.90e-01
Peptide ligand-binding receptors 102 9.75e-01 1.77e-03 9.90e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 9.76e-01 4.23e-03 9.90e-01
TRAF6 mediated IRF7 activation 16 9.76e-01 4.34e-03 9.90e-01
Interleukin-37 signaling 20 9.77e-01 -3.73e-03 9.90e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 25 9.79e-01 3.03e-03 9.91e-01
Trafficking of AMPA receptors 25 9.79e-01 3.03e-03 9.91e-01
Formation of ATP by chemiosmotic coupling 18 9.80e-01 -3.41e-03 9.91e-01
RNA polymerase II transcribes snRNA genes 71 9.83e-01 1.44e-03 9.94e-01
RHOD GTPase cycle 51 9.84e-01 -1.58e-03 9.94e-01
Activated NTRK2 signals through FRS2 and FRS3 10 9.86e-01 3.16e-03 9.94e-01
tRNA Aminoacylation 42 9.87e-01 1.48e-03 9.94e-01
Receptor-type tyrosine-protein phosphatases 14 9.87e-01 2.55e-03 9.94e-01
Cell-extracellular matrix interactions 16 9.88e-01 -2.23e-03 9.95e-01
Termination of O-glycan biosynthesis 14 9.91e-01 -1.70e-03 9.97e-01
PCNA-Dependent Long Patch Base Excision Repair 21 9.92e-01 1.24e-03 9.97e-01
Formation of the Early Elongation Complex 33 9.93e-01 -9.43e-04 9.97e-01
Formation of the HIV-1 Early Elongation Complex 33 9.93e-01 -9.43e-04 9.97e-01
Complex I biogenesis 57 9.95e-01 -5.21e-04 9.98e-01
Post-translational modification: synthesis of GPI-anchored proteins 64 9.98e-01 -2.17e-04 1.00e+00
Telomere C-strand synthesis initiation 13 9.98e-01 4.65e-04 1.00e+00
Signaling by cytosolic FGFR1 fusion mutants 18 9.99e-01 -1.96e-04 1.00e+00
Mismatch Repair 14 9.99e-01 -1.53e-04 1.00e+00
Signaling by Receptor Tyrosine Kinases 465 1.00e+00 1.36e-05 1.00e+00


Detailed Gene set reports



Initial triggering of complement

Initial triggering of complement
554
set Initial triggering of complement
setSize 49
pANOVA 7.28e-25
s.dist -0.849
p.adjustANOVA 1.05e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 -9494
CFD -9487
C1QC -9460
C1QB -9444
MASP1 -9418
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
C4A -9247
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 -9494
CFD -9487
C1QC -9460
C1QB -9444
MASP1 -9418
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
C4A -9247
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
C4B -9102
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
IGHG3 -9014
IGHG1 -8994
CFB -8939
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
C1S -8392
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
MASP2 -8175
IGKV3-15 -7850
IGLV1-44 -7694
COLEC11 -7384
IGHV3-33 -6656
C2 -6240
IGKV1-33 -2600
GZMM 3758
FCN1 9153


Classical antibody-mediated complement activation

Classical antibody-mediated complement activation
199
set Classical antibody-mediated complement activation
setSize 38
pANOVA 1.22e-22
s.dist -0.917
p.adjustANOVA 8.78e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
C1QC -9460
C1QB -9444
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C1QC -9460
C1QB -9444
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
C1S -8392
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
IGKV3-15 -7850
IGLV1-44 -7694
IGHV3-33 -6656
IGKV1-33 -2600


Creation of C4 and C2 activators

Creation of C4 and C2 activators
227
set Creation of C4 and C2 activators
setSize 42
pANOVA 1.82e-22
s.dist -0.869
p.adjustANOVA 8.78e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
C1QC -9460
C1QB -9444
MASP1 -9418
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C1QC -9460
C1QB -9444
MASP1 -9418
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
C1S -8392
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
MASP2 -8175
IGKV3-15 -7850
IGLV1-44 -7694
COLEC11 -7384
IGHV3-33 -6656
IGKV1-33 -2600
FCN1 9153


Cell Cycle

Cell Cycle
163
set Cell Cycle
setSize 611
pANOVA 8.73e-22
s.dist 0.228
p.adjustANOVA 3.15e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYBL2 9120
ZWINT 9112
CDC45 9100
PHLDA1 9055
SPDL1 9028
NDC80 8933
TK1 8930
GMNN 8906
TUBA8 8905
NUF2 8902
TUBB3 8889
SYCE1 8874
LMNB1 8850
CDKN1A 8844
RRM2 8827
KIF20A 8808
NCAPG 8796
H2AC6 8794
KIF18A 8767
BRIP1 8756

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYBL2 9120
ZWINT 9112
CDC45 9100
PHLDA1 9055
SPDL1 9028
NDC80 8933
TK1 8930
GMNN 8906
TUBA8 8905
NUF2 8902
TUBB3 8889
SYCE1 8874
LMNB1 8850
CDKN1A 8844
RRM2 8827
KIF20A 8808
NCAPG 8796
H2AC6 8794
KIF18A 8767
BRIP1 8756
BUB1B 8748
ORC6 8732
H2BC21 8730
E2F2 8720
BIRC5 8710
UBE2S 8700
PRKCB 8675
KNTC1 8660
CDC6 8647
TOP2A 8626
MCM10 8617
GTSE1 8601
TYMS 8600
CCNA2 8584
BUB1 8578
KIF23 8565
MCM8 8519
E2F5 8515
HJURP 8506
CDK2 8505
MAD2L1 8490
CEP152 8487
CDK1 8482
PKMYT1 8461
TUBB1 8440
MZT1 8424
PTTG1 8374
E2F1 8341
PIF1 8333
CENPU 8324
CENPF 8317
TEN1 8316
AURKB 8302
PPP2R1B 8292
DSCC1 8284
CCNB1 8255
ORC2 8252
CHEK1 8237
H2BC5 8216
CLSPN 8207
RAD51 8206
CCNB2 8202
CENPO 8144
RCC1 8127
SYCP2 8126
SPC24 8118
GINS2 8102
NCAPH 8091
PCNA 8082
HMMR 8073
NSD2 8036
ATR 7993
SMC4 7978
FOXM1 7954
NUP210 7953
CENPP 7938
H3-3A 7937
CDK6 7904
UBE2C 7882
CENPA 7870
MCM4 7784
NCAPG2 7780
MCM2 7760
RAD9B 7736
FBXL7 7714
TPX2 7689
NBN 7660
CDCA5 7644
CENPN 7635
LIG1 7633
CCNE2 7632
LIN9 7621
MNAT1 7615
GINS4 7604
CENPW 7594
NINL 7569
PSMC3IP 7466
NUP50 7423
TUBGCP4 7410
ZWILCH 7311
PSMA5 7283
TP53BP1 7241
CENPM 7233
RTEL1 7227
MRE11 7211
UBE2D1 7209
CDC7 7164
NUP107 7149
YWHAQ 7139
RNF168 7128
ANKLE2 7114
CENPK 7060
TUBA1A 6985
SFI1 6966
TUBGCP3 6928
NEDD1 6927
ITGB3BP 6916
CCP110 6913
TUBGCP5 6908
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
DBF4 6792
CEP70 6790
H2AZ1 6727
TERF2IP 6666
MDM2 6607
CENPI 6571
CNEP1R1 6561
HUS1 6558
MASTL 6545
NEK6 6528
ARPP19 6524
PSMD10 6444
RFC4 6443
CNTRL 6435
CC2D1B 6434
CSNK1E 6429
H2AC18 6414
CEP63 6336
CDT1 6308
KNL1 6300
ANKRD28 6297
YWHAG 6286
AKAP9 6242
LPIN2 6233
MSH5 6201
RBBP8 6197
E2F3 6127
VRK1 6125
ANAPC5 6110
NUP58 6104
CDC20 6096
BARD1 6095
E2F6 6048
HDAC1 5993
ESPL1 5967
AKT3 5964
CDKN2A 5932
PCM1 5901
PCNT 5894
CDC25A 5871
PDS5A 5785
WRN 5756
BRCA1 5710
XPO1 5625
HERC2 5616
RAB2A 5592
PSMD14 5533
H2AZ2 5520
CENPQ 5514
ANAPC10 5493
BUB3 5458
CEP250 5449
VRK2 5417
FBXW11 5410
RBL2 5386
CEP135 5383
PSMA2 5379
LEMD3 5367
PPP1CB 5311
POLR2K 5309
KPNB1 5308
GSK3B 5259
TOPBP1 5197
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
SYNE1 5138
ALMS1 5123
MAPRE1 5048
BLZF1 5034
LMNA 5022
RAD9A 4991
TERF1 4973
NDE1 4928
PSMD1 4898
OPTN 4873
UBE2N 4863
CCNE1 4861
NOP10 4819
DSN1 4816
ANAPC15 4796
PSMD12 4794
MAPK1 4733
ESCO2 4701
TFDP1 4675
NUP37 4625
PRIM2 4619
CEP41 4601
DHFR 4581
NEK7 4564
RBL1 4559
PSMC6 4558
KIF2A 4530
CEP290 4523
TAOK1 4480
PSME4 4470
SEH1L 4433
MIS18BP1 4411
PPP2R5A 4400
RAN 4331
PLK4 4324
AHCTF1 4308
STAG3 4301
CDKN2D 4290
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
CEP43 4210
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
SET 3962
PSMB4 3958
SUN1 3944
TNPO1 3915
PSMB7 3904
CENPH 3875
NME7 3870
POLE2 3809
PSMD11 3785
H2BU1 3777
SKA1 3729
PRKCA 3672
CLASP2 3637
PSME2 3582
CDK7 3563
RNF8 3536
HSPA2 3522
PPP2R5C 3488
PPP2R2A 3477
RBBP7 3467
PSMD7 3466
RAD51C 3449
BORA 3425
CKAP5 3402
SEM1 3400
RAD21 3358
UBE2V2 3351
BLM 3335
RBX1 3283
MLH3 3269
RAB1A 3247
PSMA4 3210
WAPL 3203
AURKA 3195
MCM5 3190
WEE1 3185
DNA2 3175
PLK1 3164
POLR2A 3139
PSMD9 3119
YWHAZ 3108
SGO2 3092
TUBA1C 3049
NEK2 3008
PSMA7 2958
CHMP3 2956
CCNH 2900
TUBB2A 2864
PPP2CB 2822
CLIP1 2815
POLR2G 2775
MDM4 2774
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
NUP153 2683
CEP164 2634
SPC25 2593
PPP2R5B 2592
USO1 2502
RFC2 2464
SKP1 2463
LBR 2457
LYN 2420
NUP85 2385
PSMA6 2325
HDAC8 2302
SUMO1 2289
PPP1R12A 2230
UIMC1 2202
PSMB1 2193
POLA1 2171
RB1 2164
NDEL1 2105
PDS5B 2055
POLD3 1954
ATM 1949
STAG1 1913
CENPL 1908
JAK2 1898
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
RMI1 1762
OFD1 1761
HAUS5 1667
NEK9 1631
PSMB5 1588
DYNLL1 1561
HAUS6 1519
CEP78 1504
PIAS4 1497
YWHAE 1494
MLH1 1492
ESCO1 1489
CHTF18 1481
DYRK1A 1478
NUP205 1456
FEN1 1436
LIN54 1433
POLR2D 1389
SKP2 1310
BRCC3 1272
RMI2 1266
UBB 1263
H2BC4 1261
ANAPC11 1164
CENPT 1162
BRCA2 1156
PSME3 1142
RANBP2 1105
MCM7 1095
REC8 1044
MIS12 1040
NPM1 985
CEP192 984
NIPBL 980
CDK5RAP2 958
SMC2 946
PHF8 882
B9D2 872
SMC1A 853
H2AJ 847
SHQ1 830
HSP90AA1 820
PSMB2 809
NUMA1 790
PSMB3 777
MCM3 755
TUBG2 726
POLD1 667
FBXO5 650
NUP155 640
ATRX 632
CTC1 535
MAU2 522
RAD17 494
CEP76 490
CEP57 474
PTK6 448
CDK4 424
TUBA1B 379
PSMC2 361
HSP90AB1 348
POLR2F 326
MAX 321
MCM6 313
CCND2 281
CETN2 224
DMC1 163
PPP6R3 120
SMC3 116
CKS1B 101
ORC3 83
RFC5 70
AKT1 46
RUVBL1 -35
CEP72 -71
PCBP4 -83
RBBP4 -106
FKBPL -141
KMT5A -231
LPIN1 -235
TUBB4B -239
SEC13 -240
ANAPC7 -246
GINS1 -255
EMD -259
MZT2A -357
NCAPD2 -396
EP300 -408
WRAP53 -430
PPME1 -432
AKT2 -435
FZR1 -437
PSMA3 -465
PSMD2 -498
UBC -514
CDC25B -519
CSNK2A1 -543
POT1 -557
TUBGCP6 -558
MCPH1 -575
NCAPD3 -600
PMF1 -611
LIN37 -764
CHMP2B -785
CENPJ -806
POLR2L -828
HAUS3 -853
PSMD8 -867
CDC14A -900
YWHAB -909
PSMD5 -915
NDC1 -928
SMARCA5 -977
CCND1 -983
RPA3 -1004
DYNC1H1 -1028
CDKN1B -1066
TUBGCP2 -1103
RAB8A -1131
ANAPC1 -1157
PPP2R3B -1160
GAR1 -1186
ACTR1A -1197
RSF1 -1230
ORC4 -1247
PSMD6 -1289
PRIM1 -1353
ORC1 -1359
DCTN3 -1385
MZT2B -1440
RAD1 -1451
PSMD13 -1463
PPP1CC -1467
DKC1 -1526
GOLGA2 -1531
PPP6C -1554
DYNC1I1 -1561
POLR2B -1647
ANAPC2 -1671
FBXL18 -1685
CDC27 -1716
SDCCAG8 -1729
NUP43 -1806
HAUS7 -1810
TUBA4A -1872
RFC1 -1874
CDC26 -1879
POLR2H -1884
POLE -1893
POLR2J -1920
ENSA -1924
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
TUBB -2087
SSNA1 -2131
MDC1 -2140
PPP2R2D -2205
SYCP3 -2222
POM121C -2270
NUP62 -2277
POLR2I -2338
CSNK2B -2342
LIN52 -2405
DCTN2 -2463
NUP88 -2497
CEP131 -2518
HAUS1 -2630
PSMC3 -2697
BABAM1 -2725
NUP54 -2777
NUP35 -2799
TUBB6 -2838
LCMT1 -2912
RAE1 -2951
TOP3A -3014
RFC3 -3056
HAUS2 -3059
ODF2 -3131
LEMD2 -3149
BTRC -3151
ANAPC16 -3165
HAUS4 -3269
CHMP4B -3274
PSMD4 -3294
RCC2 -3305
CHMP6 -3324
BANF1 -3381
RPS27A -3448
CHMP4A -3463
SPAST -3529
EML4 -3573
TMPO -3596
NUP93 -3615
NUP133 -3621
LPIN3 -3644
CHMP2A -3676
TPR -3680
GORASP1 -3774
PSMC4 -3885
NUP188 -3894
UBE2I -3998
INCENP -4011
OIP5 -4115
CDC23 -4123
SFN -4148
CSNK2A2 -4159
IST1 -4205
PSMB8 -4218
POLR2C -4257
CUL1 -4413
UBA52 -4448
CCND3 -4456
ORC5 -4482
PSME1 -4498
STN1 -4513
NHP2 -4544
PPP2R5D -4551
CDKN2C -4554
TUBB2B -4592
NCAPH2 -4594
RPA1 -4619
ACD -4659
AAAS -4689
YWHAH -4728
PPP1R12B -4730
PSMD3 -4749
NUP42 -4798
DIDO1 -4830
AJUBA -4881
TUBG1 -4887
CDKN2B -4930
SIRT2 -5022
MIS18A -5063
CHTF8 -5066
POLE3 -5073
RUVBL2 -5162
GORASP2 -5187
RHNO1 -5228
POM121 -5296
TINF2 -5398
RPS27 -5510
ZNF385A -5520
RANGAP1 -5521
POLE4 -5525
ABL1 -5571
HAUS8 -5594
PSMB10 -5760
NUDC -5900
POLD2 -5903
TERF2 -5951
PHF20 -6002
CHMP7 -6046
SRC -6078
DCTN1 -6110
ATRIP -6125
GINS3 -6131
SYNE2 -6199
RAB1B -6215
H2BC12 -6254
NUP98 -6316
SUN2 -6370
VPS4A -6410
TUBAL3 -6418
CSNK1D -6568
POLA2 -6749
DYNLL2 -6837
CDK11B -6884
PSMB9 -6888
MAPK3 -6930
E2F4 -6983
POLR2E -7044
RPA2 -7206
DAXX -7279
PPP2R1A -7410
RAD50 -7432
CDKN1C -7514
PSMF1 -7531
CDK11A -7537
KAT5 -7538
PRKACA -7564
SYCE2 -7724
CABLES1 -7835
POLD4 -7884
NUP214 -8027
CHEK2 -8067
TFDP2 -8168
TP53 -8197
CTDNEP1 -8251
PRKAR2B -8427
MYC -8970


Cell Cycle, Mitotic

Cell Cycle, Mitotic
165
set Cell Cycle, Mitotic
setSize 495
pANOVA 7.83e-20
s.dist 0.239
p.adjustANOVA 2.26e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYBL2 9120
ZWINT 9112
CDC45 9100
PHLDA1 9055
SPDL1 9028
NDC80 8933
TK1 8930
GMNN 8906
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
CDKN1A 8844
RRM2 8827
KIF20A 8808
NCAPG 8796
H2AC6 8794
KIF18A 8767
BUB1B 8748
ORC6 8732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYBL2 9120
ZWINT 9112
CDC45 9100
PHLDA1 9055
SPDL1 9028
NDC80 8933
TK1 8930
GMNN 8906
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
CDKN1A 8844
RRM2 8827
KIF20A 8808
NCAPG 8796
H2AC6 8794
KIF18A 8767
BUB1B 8748
ORC6 8732
H2BC21 8730
E2F2 8720
BIRC5 8710
UBE2S 8700
PRKCB 8675
KNTC1 8660
CDC6 8647
TOP2A 8626
MCM10 8617
GTSE1 8601
TYMS 8600
CCNA2 8584
BUB1 8578
KIF23 8565
MCM8 8519
E2F5 8515
CDK2 8505
MAD2L1 8490
CEP152 8487
CDK1 8482
PKMYT1 8461
TUBB1 8440
MZT1 8424
PTTG1 8374
E2F1 8341
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
ORC2 8252
H2BC5 8216
CCNB2 8202
CENPO 8144
RCC1 8127
SPC24 8118
GINS2 8102
NCAPH 8091
PCNA 8082
HMMR 8073
SMC4 7978
FOXM1 7954
NUP210 7953
CENPP 7938
H3-3A 7937
CDK6 7904
UBE2C 7882
CENPA 7870
MCM4 7784
NCAPG2 7780
MCM2 7760
FBXL7 7714
TPX2 7689
CDCA5 7644
CENPN 7635
LIG1 7633
CCNE2 7632
LIN9 7621
MNAT1 7615
GINS4 7604
NINL 7569
NUP50 7423
TUBGCP4 7410
ZWILCH 7311
PSMA5 7283
CENPM 7233
UBE2D1 7209
CDC7 7164
NUP107 7149
ANKLE2 7114
CENPK 7060
TUBA1A 6985
SFI1 6966
TUBGCP3 6928
NEDD1 6927
ITGB3BP 6916
CCP110 6913
TUBGCP5 6908
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
DBF4 6792
CEP70 6790
H2AZ1 6727
CENPI 6571
CNEP1R1 6561
MASTL 6545
NEK6 6528
ARPP19 6524
PSMD10 6444
RFC4 6443
CNTRL 6435
CC2D1B 6434
CSNK1E 6429
H2AC18 6414
CEP63 6336
CDT1 6308
KNL1 6300
YWHAG 6286
AKAP9 6242
LPIN2 6233
E2F3 6127
VRK1 6125
ANAPC5 6110
NUP58 6104
CDC20 6096
E2F6 6048
HDAC1 5993
ESPL1 5967
AKT3 5964
CDKN2A 5932
PCM1 5901
PCNT 5894
CDC25A 5871
PDS5A 5785
XPO1 5625
RAB2A 5592
PSMD14 5533
H2AZ2 5520
CENPQ 5514
ANAPC10 5493
BUB3 5458
CEP250 5449
VRK2 5417
FBXW11 5410
RBL2 5386
CEP135 5383
PSMA2 5379
LEMD3 5367
PPP1CB 5311
KPNB1 5308
GSK3B 5259
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
ALMS1 5123
MAPRE1 5048
BLZF1 5034
LMNA 5022
NDE1 4928
PSMD1 4898
OPTN 4873
CCNE1 4861
DSN1 4816
ANAPC15 4796
PSMD12 4794
MAPK1 4733
ESCO2 4701
TFDP1 4675
NUP37 4625
PRIM2 4619
CEP41 4601
DHFR 4581
NEK7 4564
RBL1 4559
PSMC6 4558
KIF2A 4530
CEP290 4523
TAOK1 4480
PSME4 4470
SEH1L 4433
PPP2R5A 4400
RAN 4331
PLK4 4324
AHCTF1 4308
CDKN2D 4290
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
CEP43 4210
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
SET 3962
PSMB4 3958
TNPO1 3915
PSMB7 3904
CENPH 3875
NME7 3870
POLE2 3809
PSMD11 3785
H2BU1 3777
SKA1 3729
PRKCA 3672
CLASP2 3637
PSME2 3582
CDK7 3563
PPP2R5C 3488
PPP2R2A 3477
PSMD7 3466
BORA 3425
CKAP5 3402
SEM1 3400
RAD21 3358
RBX1 3283
RAB1A 3247
PSMA4 3210
WAPL 3203
AURKA 3195
MCM5 3190
WEE1 3185
DNA2 3175
PLK1 3164
PSMD9 3119
SGO2 3092
TUBA1C 3049
NEK2 3008
PSMA7 2958
CHMP3 2956
CCNH 2900
TUBB2A 2864
PPP2CB 2822
CLIP1 2815
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
NUP153 2683
CEP164 2634
SPC25 2593
PPP2R5B 2592
USO1 2502
RFC2 2464
SKP1 2463
LBR 2457
LYN 2420
NUP85 2385
PSMA6 2325
HDAC8 2302
SUMO1 2289
PPP1R12A 2230
PSMB1 2193
POLA1 2171
RB1 2164
NDEL1 2105
PDS5B 2055
POLD3 1954
STAG1 1913
CENPL 1908
JAK2 1898
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
OFD1 1761
HAUS5 1667
NEK9 1631
PSMB5 1588
DYNLL1 1561
HAUS6 1519
CEP78 1504
YWHAE 1494
ESCO1 1489
DYRK1A 1478
NUP205 1456
FEN1 1436
LIN54 1433
SKP2 1310
UBB 1263
H2BC4 1261
ANAPC11 1164
CENPT 1162
PSME3 1142
RANBP2 1105
MCM7 1095
MIS12 1040
CEP192 984
NIPBL 980
CDK5RAP2 958
SMC2 946
PHF8 882
B9D2 872
SMC1A 853
H2AJ 847
HSP90AA1 820
PSMB2 809
NUMA1 790
PSMB3 777
MCM3 755
TUBG2 726
POLD1 667
FBXO5 650
NUP155 640
MAU2 522
CEP76 490
CEP57 474
PTK6 448
CDK4 424
TUBA1B 379
PSMC2 361
HSP90AB1 348
MAX 321
MCM6 313
CCND2 281
CETN2 224
SMC3 116
CKS1B 101
ORC3 83
RFC5 70
AKT1 46
CEP72 -71
RBBP4 -106
FKBPL -141
KMT5A -231
LPIN1 -235
TUBB4B -239
SEC13 -240
ANAPC7 -246
GINS1 -255
EMD -259
MZT2A -357
NCAPD2 -396
EP300 -408
PPME1 -432
AKT2 -435
FZR1 -437
PSMA3 -465
PSMD2 -498
UBC -514
CDC25B -519
CSNK2A1 -543
TUBGCP6 -558
MCPH1 -575
NCAPD3 -600
PMF1 -611
LIN37 -764
CHMP2B -785
CENPJ -806
HAUS3 -853
PSMD8 -867
CDC14A -900
PSMD5 -915
NDC1 -928
CCND1 -983
RPA3 -1004
DYNC1H1 -1028
CDKN1B -1066
TUBGCP2 -1103
RAB8A -1131
ANAPC1 -1157
PPP2R3B -1160
ACTR1A -1197
ORC4 -1247
PSMD6 -1289
PRIM1 -1353
ORC1 -1359
DCTN3 -1385
MZT2B -1440
PSMD13 -1463
PPP1CC -1467
GOLGA2 -1531
DYNC1I1 -1561
ANAPC2 -1671
FBXL18 -1685
CDC27 -1716
SDCCAG8 -1729
NUP43 -1806
HAUS7 -1810
TUBA4A -1872
RFC1 -1874
CDC26 -1879
POLE -1893
ENSA -1924
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
TUBB -2087
SSNA1 -2131
PPP2R2D -2205
POM121C -2270
NUP62 -2277
CSNK2B -2342
LIN52 -2405
DCTN2 -2463
NUP88 -2497
CEP131 -2518
HAUS1 -2630
PSMC3 -2697
NUP54 -2777
NUP35 -2799
TUBB6 -2838
LCMT1 -2912
RAE1 -2951
RFC3 -3056
HAUS2 -3059
ODF2 -3131
LEMD2 -3149
BTRC -3151
ANAPC16 -3165
HAUS4 -3269
CHMP4B -3274
PSMD4 -3294
RCC2 -3305
CHMP6 -3324
BANF1 -3381
RPS27A -3448
CHMP4A -3463
SPAST -3529
EML4 -3573
TMPO -3596
NUP93 -3615
NUP133 -3621
LPIN3 -3644
CHMP2A -3676
TPR -3680
GORASP1 -3774
PSMC4 -3885
NUP188 -3894
UBE2I -3998
INCENP -4011
CDC23 -4123
CSNK2A2 -4159
IST1 -4205
PSMB8 -4218
CUL1 -4413
UBA52 -4448
CCND3 -4456
ORC5 -4482
PSME1 -4498
PPP2R5D -4551
CDKN2C -4554
TUBB2B -4592
NCAPH2 -4594
RPA1 -4619
AAAS -4689
PPP1R12B -4730
PSMD3 -4749
NUP42 -4798
AJUBA -4881
TUBG1 -4887
CDKN2B -4930
SIRT2 -5022
POLE3 -5073
GORASP2 -5187
POM121 -5296
RPS27 -5510
RANGAP1 -5521
POLE4 -5525
ABL1 -5571
HAUS8 -5594
PSMB10 -5760
NUDC -5900
POLD2 -5903
CHMP7 -6046
SRC -6078
DCTN1 -6110
GINS3 -6131
RAB1B -6215
H2BC12 -6254
NUP98 -6316
VPS4A -6410
TUBAL3 -6418
CSNK1D -6568
POLA2 -6749
DYNLL2 -6837
CDK11B -6884
PSMB9 -6888
MAPK3 -6930
E2F4 -6983
RPA2 -7206
PPP2R1A -7410
CDKN1C -7514
PSMF1 -7531
CDK11A -7537
PRKACA -7564
CABLES1 -7835
POLD4 -7884
NUP214 -8027
TFDP2 -8168
TP53 -8197
CTDNEP1 -8251
PRKAR2B -8427
MYC -8970


Complement cascade

Complement cascade
211
set Complement cascade
setSize 72
pANOVA 2.06e-19
s.dist -0.614
p.adjustANOVA 4.96e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
C6 -9495
C3 -9494
CFD -9487
C1QC -9460
C1QB -9444
C7 -9441
MASP1 -9418
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
CR2 -9332
IGLV2-14 -9330
IGKV1-5 -9324
CFH -9298
C4A -9247
SERPING1 -9246
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C6 -9495
C3 -9494
CFD -9487
C1QC -9460
C1QB -9444
C7 -9441
MASP1 -9418
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
CR2 -9332
IGLV2-14 -9330
IGKV1-5 -9324
CFH -9298
C4A -9247
SERPING1 -9246
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
CFHR1 -9108
C4B -9102
IGLV2-11 -9099
IGHG2 -9096
C3AR1 -9074
IGKV3-20 -9063
IGLV2-8 -9051
IGHG3 -9014
IGHG1 -8994
CFB -8939
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
C1S -8392
IGLV3-1 -8321
IGHV3-13 -8306
CFI -8279
IGLC1 -8206
CD81 -8181
MASP2 -8175
IGKV3-15 -7850
IGLV1-44 -7694
PROS1 -7573
COLEC11 -7384
IGHV3-33 -6656
C2 -6240
VTN -3188
IGKV1-33 -2600
CD55 -1096
C4BPB 1511
CR1 1586
CLU 2015
GZMM 3758
CD59 5134
C5AR1 6388
CD46 7693
ELANE 7952
C5 8134
C5AR2 8295
CPN2 8635
C4BPA 9087
FCN1 9153


Regulation of Complement cascade

Regulation of Complement cascade
1003
set Regulation of Complement cascade
setSize 66
pANOVA 4.02e-19
s.dist -0.636
p.adjustANOVA 8.28e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
C6 -9495
C3 -9494
C1QC -9460
C1QB -9444
C7 -9441
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
CR2 -9332
IGLV2-14 -9330
IGKV1-5 -9324
CFH -9298
C4A -9247
SERPING1 -9246
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C6 -9495
C3 -9494
C1QC -9460
C1QB -9444
C7 -9441
IGKV3-11 -9413
IGHV1-2 -9408
C1QA -9396
IGHV3-30 -9344
CR2 -9332
IGLV2-14 -9330
IGKV1-5 -9324
CFH -9298
C4A -9247
SERPING1 -9246
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
C1R -9125
CFHR1 -9108
C4B -9102
IGLV2-11 -9099
IGHG2 -9096
C3AR1 -9074
IGKV3-20 -9063
IGLV2-8 -9051
IGHG3 -9014
IGHG1 -8994
CFB -8939
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
C1S -8392
IGLV3-1 -8321
IGHV3-13 -8306
CFI -8279
IGLC1 -8206
CD81 -8181
IGKV3-15 -7850
IGLV1-44 -7694
PROS1 -7573
IGHV3-33 -6656
C2 -6240
VTN -3188
IGKV1-33 -2600
CD55 -1096
C4BPB 1511
CR1 1586
CLU 2015
CD59 5134
C5AR1 6388
CD46 7693
ELANE 7952
C5 8134
C5AR2 8295
CPN2 8635
C4BPA 9087


Scavenging of heme from plasma

Scavenging of heme from plasma
1113
set Scavenging of heme from plasma
setSize 39
pANOVA 2.7e-18
s.dist -0.807
p.adjustANOVA 4.86e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
HP -9316
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
JCHAIN -9064
IGKV3-20 -9063
IGLV2-8 -9051
APOL1 -9007
IGHV2-5 -8925
IGLV1-51 -8906

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
HP -9316
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
JCHAIN -9064
IGKV3-20 -9063
IGLV2-8 -9051
APOL1 -9007
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
LRP1 -8365
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
CD163 -8045
IGKV3-15 -7850
IGLV1-44 -7694
IGHV3-33 -6656
HPX -6398
IGHA1 -5242
IGHA2 -4406
IGKV1-33 -2600
HBA1 4074
HBB 5452


Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors
114
set Binding and Uptake of Ligands by Scavenger Receptors
setSize 66
pANOVA 1.12e-17
s.dist -0.609
p.adjustANOVA 1.79e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
MASP1 -9418
IGKV3-11 -9413
SCARA5 -9410
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
HP -9316
IGLC2 -9238
IGLV3-25 -9227
STAB1 -9212
APOB -9192
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
JCHAIN -9064
IGKV3-20 -9063

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MASP1 -9418
IGKV3-11 -9413
SCARA5 -9410
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
HP -9316
IGLC2 -9238
IGLV3-25 -9227
STAB1 -9212
APOB -9192
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
JCHAIN -9064
IGKV3-20 -9063
IGLV2-8 -9051
APOL1 -9007
MARCO -8983
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
SCARB1 -8653
IGKV1D-39 -8562
IGHV4-59 -8467
LRP1 -8365
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
CD163 -8045
HYOU1 -7999
IGKV3-15 -7850
IGLV1-44 -7694
COLEC11 -7384
COLEC12 -7351
IGHV3-33 -6656
HPX -6398
SSC5D -6225
CD36 -5281
IGHA1 -5242
IGHA2 -4406
MSR1 -4362
APOE -2874
IGKV1-33 -2600
HSP90B1 -2549
FTL -2148
CALR -2057
SAA1 -1335
SPARC -926
COL4A2 -763
SCARF1 540
HSP90AA1 820
COL1A2 1437
COL3A1 1755
COL4A1 3883
COL1A1 3957
HSPH1 3961
HBA1 4074
FTH1 4795
HBB 5452


Cell Cycle Checkpoints

Cell Cycle Checkpoints
164
set Cell Cycle Checkpoints
setSize 252
pANOVA 1.4e-17
s.dist 0.312
p.adjustANOVA 2.02e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
CDC45 9100
SPDL1 9028
NDC80 8933
NUF2 8902
CDKN1A 8844
KIF18A 8767
BRIP1 8756
BUB1B 8748
ORC6 8732
H2BC21 8730
BIRC5 8710
UBE2S 8700
KNTC1 8660
CDC6 8647
MCM10 8617
GTSE1 8601
CCNA2 8584
BUB1 8578
MCM8 8519

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
CDC45 9100
SPDL1 9028
NDC80 8933
NUF2 8902
CDKN1A 8844
KIF18A 8767
BRIP1 8756
BUB1B 8748
ORC6 8732
H2BC21 8730
BIRC5 8710
UBE2S 8700
KNTC1 8660
CDC6 8647
MCM10 8617
GTSE1 8601
CCNA2 8584
BUB1 8578
MCM8 8519
CDK2 8505
MAD2L1 8490
CDK1 8482
PKMYT1 8461
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
ORC2 8252
CHEK1 8237
H2BC5 8216
CLSPN 8207
CCNB2 8202
CENPO 8144
SPC24 8118
NSD2 8036
ATR 7993
CENPP 7938
UBE2C 7882
CENPA 7870
MCM4 7784
MCM2 7760
RAD9B 7736
NBN 7660
CENPN 7635
CCNE2 7632
ZWILCH 7311
PSMA5 7283
TP53BP1 7241
CENPM 7233
MRE11 7211
UBE2D1 7209
CDC7 7164
NUP107 7149
YWHAQ 7139
RNF168 7128
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
DBF4 6792
MDM2 6607
CENPI 6571
HUS1 6558
PSMD10 6444
RFC4 6443
KNL1 6300
YWHAG 6286
RBBP8 6197
ANAPC5 6110
CDC20 6096
BARD1 6095
CDKN2A 5932
CDC25A 5871
WRN 5756
BRCA1 5710
XPO1 5625
HERC2 5616
PSMD14 5533
CENPQ 5514
ANAPC10 5493
BUB3 5458
PSMA2 5379
TOPBP1 5197
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
MAPRE1 5048
RAD9A 4991
NDE1 4928
PSMD1 4898
UBE2N 4863
CCNE1 4861
DSN1 4816
ANAPC15 4796
PSMD12 4794
NUP37 4625
PSMC6 4558
KIF2A 4530
TAOK1 4480
PSME4 4470
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
PSMB4 3958
PSMB7 3904
CENPH 3875
PSMD11 3785
H2BU1 3777
SKA1 3729
CLASP2 3637
PSME2 3582
RNF8 3536
PPP2R5C 3488
PSMD7 3466
CKAP5 3402
SEM1 3400
UBE2V2 3351
BLM 3335
PSMA4 3210
MCM5 3190
WEE1 3185
DNA2 3175
PLK1 3164
PSMD9 3119
YWHAZ 3108
SGO2 3092
PSMA7 2958
PPP2CB 2822
CLIP1 2815
MDM4 2774
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
RFC2 2464
NUP85 2385
PSMA6 2325
SUMO1 2289
UIMC1 2202
PSMB1 2193
NDEL1 2105
ATM 1949
CENPL 1908
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
RMI1 1762
PSMB5 1588
DYNLL1 1561
PIAS4 1497
YWHAE 1494
BRCC3 1272
RMI2 1266
UBB 1263
H2BC4 1261
ANAPC11 1164
CENPT 1162
PSME3 1142
RANBP2 1105
MCM7 1095
MIS12 1040
B9D2 872
PSMB2 809
PSMB3 777
MCM3 755
RAD17 494
PSMC2 361
MCM6 313
ORC3 83
RFC5 70
PCBP4 -83
SEC13 -240
ANAPC7 -246
PSMA3 -465
PSMD2 -498
UBC -514
PMF1 -611
PSMD8 -867
YWHAB -909
PSMD5 -915
RPA3 -1004
DYNC1H1 -1028
CDKN1B -1066
ANAPC1 -1157
ORC4 -1247
PSMD6 -1289
ORC1 -1359
RAD1 -1451
PSMD13 -1463
PPP1CC -1467
DYNC1I1 -1561
ANAPC2 -1671
CDC27 -1716
NUP43 -1806
CDC26 -1879
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
MDC1 -2140
PSMC3 -2697
BABAM1 -2725
TOP3A -3014
RFC3 -3056
ANAPC16 -3165
PSMD4 -3294
RCC2 -3305
RPS27A -3448
NUP133 -3621
PSMC4 -3885
INCENP -4011
CDC23 -4123
SFN -4148
PSMB8 -4218
UBA52 -4448
ORC5 -4482
PSME1 -4498
PPP2R5D -4551
RPA1 -4619
YWHAH -4728
PSMD3 -4749
RHNO1 -5228
RPS27 -5510
ZNF385A -5520
RANGAP1 -5521
PSMB10 -5760
NUDC -5900
PHF20 -6002
ATRIP -6125
H2BC12 -6254
NUP98 -6316
DYNLL2 -6837
PSMB9 -6888
RPA2 -7206
PPP2R1A -7410
RAD50 -7432
PSMF1 -7531
KAT5 -7538
CHEK2 -8067
TP53 -8197


FCGR activation

FCGR activation
380
set FCGR activation
setSize 45
pANOVA 3.96e-16
s.dist -0.701
p.adjustANOVA 5.19e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
IGKV3-15 -7850
IGLV1-44 -7694
SYK -7360
IGHV3-33 -6656
SRC -6078
HCK -4732
IGKV1-33 -2600
FCGR1A 592
LYN 2420
CD3G 3144
YES1 5910
FGR 7542
CD247 8946


M Phase

M Phase
633
set M Phase
setSize 354
pANOVA 1.43e-14
s.dist 0.238
p.adjustANOVA 1.72e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
KIF20A 8808
NCAPG 8796
H2AC6 8794
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
UBE2S 8700
PRKCB 8675
KNTC1 8660
BUB1 8578
KIF23 8565
MAD2L1 8490

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
KIF20A 8808
NCAPG 8796
H2AC6 8794
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
UBE2S 8700
PRKCB 8675
KNTC1 8660
BUB1 8578
KIF23 8565
MAD2L1 8490
CEP152 8487
CDK1 8482
TUBB1 8440
MZT1 8424
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
H2BC5 8216
CCNB2 8202
CENPO 8144
RCC1 8127
SPC24 8118
NCAPH 8091
SMC4 7978
NUP210 7953
CENPP 7938
H3-3A 7937
UBE2C 7882
CENPA 7870
NCAPG2 7780
CDCA5 7644
CENPN 7635
NINL 7569
NUP50 7423
TUBGCP4 7410
ZWILCH 7311
PSMA5 7283
CENPM 7233
UBE2D1 7209
NUP107 7149
ANKLE2 7114
CENPK 7060
TUBA1A 6985
SFI1 6966
TUBGCP3 6928
NEDD1 6927
ITGB3BP 6916
CCP110 6913
TUBGCP5 6908
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
CEP70 6790
H2AZ1 6727
CENPI 6571
CNEP1R1 6561
MASTL 6545
NEK6 6528
ARPP19 6524
PSMD10 6444
CNTRL 6435
CC2D1B 6434
CSNK1E 6429
H2AC18 6414
CEP63 6336
KNL1 6300
YWHAG 6286
AKAP9 6242
LPIN2 6233
VRK1 6125
ANAPC5 6110
NUP58 6104
CDC20 6096
ESPL1 5967
PCM1 5901
PCNT 5894
PDS5A 5785
XPO1 5625
RAB2A 5592
PSMD14 5533
H2AZ2 5520
CENPQ 5514
ANAPC10 5493
BUB3 5458
CEP250 5449
VRK2 5417
CEP135 5383
PSMA2 5379
LEMD3 5367
KPNB1 5308
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
ALMS1 5123
MAPRE1 5048
BLZF1 5034
LMNA 5022
NDE1 4928
PSMD1 4898
DSN1 4816
ANAPC15 4796
PSMD12 4794
MAPK1 4733
NUP37 4625
CEP41 4601
NEK7 4564
PSMC6 4558
KIF2A 4530
CEP290 4523
TAOK1 4480
PSME4 4470
SEH1L 4433
PPP2R5A 4400
RAN 4331
PLK4 4324
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
CEP43 4210
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
SET 3962
PSMB4 3958
TNPO1 3915
PSMB7 3904
CENPH 3875
NME7 3870
PSMD11 3785
H2BU1 3777
SKA1 3729
PRKCA 3672
CLASP2 3637
PSME2 3582
PPP2R5C 3488
PPP2R2A 3477
PSMD7 3466
CKAP5 3402
SEM1 3400
RAD21 3358
RAB1A 3247
PSMA4 3210
WAPL 3203
PLK1 3164
PSMD9 3119
SGO2 3092
TUBA1C 3049
NEK2 3008
PSMA7 2958
CHMP3 2956
TUBB2A 2864
PPP2CB 2822
CLIP1 2815
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
NUP153 2683
CEP164 2634
SPC25 2593
PPP2R5B 2592
USO1 2502
LBR 2457
NUP85 2385
PSMA6 2325
HDAC8 2302
SUMO1 2289
PSMB1 2193
RB1 2164
NDEL1 2105
PDS5B 2055
STAG1 1913
CENPL 1908
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
OFD1 1761
HAUS5 1667
NEK9 1631
PSMB5 1588
DYNLL1 1561
HAUS6 1519
CEP78 1504
YWHAE 1494
NUP205 1456
UBB 1263
H2BC4 1261
ANAPC11 1164
CENPT 1162
PSME3 1142
RANBP2 1105
MIS12 1040
CEP192 984
NIPBL 980
CDK5RAP2 958
SMC2 946
PHF8 882
B9D2 872
SMC1A 853
H2AJ 847
HSP90AA1 820
PSMB2 809
NUMA1 790
PSMB3 777
TUBG2 726
FBXO5 650
NUP155 640
MAU2 522
CEP76 490
CEP57 474
TUBA1B 379
PSMC2 361
CETN2 224
SMC3 116
CEP72 -71
KMT5A -231
LPIN1 -235
TUBB4B -239
SEC13 -240
ANAPC7 -246
EMD -259
MZT2A -357
NCAPD2 -396
PSMA3 -465
PSMD2 -498
UBC -514
CSNK2A1 -543
TUBGCP6 -558
MCPH1 -575
NCAPD3 -600
PMF1 -611
CHMP2B -785
CENPJ -806
HAUS3 -853
PSMD8 -867
PSMD5 -915
NDC1 -928
DYNC1H1 -1028
TUBGCP2 -1103
ANAPC1 -1157
ACTR1A -1197
PSMD6 -1289
DCTN3 -1385
MZT2B -1440
PSMD13 -1463
PPP1CC -1467
GOLGA2 -1531
DYNC1I1 -1561
ANAPC2 -1671
CDC27 -1716
SDCCAG8 -1729
NUP43 -1806
HAUS7 -1810
TUBA4A -1872
CDC26 -1879
ENSA -1924
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
TUBB -2087
SSNA1 -2131
PPP2R2D -2205
POM121C -2270
NUP62 -2277
CSNK2B -2342
DCTN2 -2463
NUP88 -2497
CEP131 -2518
HAUS1 -2630
PSMC3 -2697
NUP54 -2777
NUP35 -2799
TUBB6 -2838
RAE1 -2951
HAUS2 -3059
ODF2 -3131
LEMD2 -3149
ANAPC16 -3165
HAUS4 -3269
CHMP4B -3274
PSMD4 -3294
RCC2 -3305
CHMP6 -3324
BANF1 -3381
RPS27A -3448
CHMP4A -3463
SPAST -3529
EML4 -3573
TMPO -3596
NUP93 -3615
NUP133 -3621
LPIN3 -3644
CHMP2A -3676
TPR -3680
GORASP1 -3774
PSMC4 -3885
NUP188 -3894
UBE2I -3998
INCENP -4011
CDC23 -4123
CSNK2A2 -4159
IST1 -4205
PSMB8 -4218
UBA52 -4448
PSME1 -4498
PPP2R5D -4551
TUBB2B -4592
NCAPH2 -4594
AAAS -4689
PSMD3 -4749
NUP42 -4798
TUBG1 -4887
SIRT2 -5022
GORASP2 -5187
POM121 -5296
RPS27 -5510
RANGAP1 -5521
HAUS8 -5594
PSMB10 -5760
NUDC -5900
CHMP7 -6046
DCTN1 -6110
RAB1B -6215
H2BC12 -6254
NUP98 -6316
VPS4A -6410
TUBAL3 -6418
CSNK1D -6568
DYNLL2 -6837
PSMB9 -6888
MAPK3 -6930
PPP2R1A -7410
PSMF1 -7531
PRKACA -7564
NUP214 -8027
CTDNEP1 -8251
PRKAR2B -8427


CD22 mediated BCR regulation

CD22 mediated BCR regulation
127
set CD22 mediated BCR regulation
setSize 36
pANOVA 1.71e-14
s.dist -0.738
p.adjustANOVA 1.9e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHD -9093
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHD -9093
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
IGKV3-15 -7850
IGLV1-44 -7694
IGHM -7037
IGHV3-33 -6656
PTPN6 -2920
IGKV1-33 -2600
CD79A -871
LYN 2420
CD22 4869
CD79B 8221


Mitotic Prometaphase

Mitotic Prometaphase
702
set Mitotic Prometaphase
setSize 184
pANOVA 1.24e-13
s.dist 0.317
p.adjustANOVA 1.28e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
NCAPG 8796
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CEP152 8487
CDK1 8482
MZT1 8424
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
CCNB2 8202

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
NCAPG 8796
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CEP152 8487
CDK1 8482
MZT1 8424
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
CENPO 8144
SPC24 8118
NCAPH 8091
SMC4 7978
CENPP 7938
CENPA 7870
CDCA5 7644
CENPN 7635
NINL 7569
TUBGCP4 7410
ZWILCH 7311
CENPM 7233
NUP107 7149
CENPK 7060
TUBA1A 6985
SFI1 6966
TUBGCP3 6928
NEDD1 6927
ITGB3BP 6916
CCP110 6913
TUBGCP5 6908
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
CEP70 6790
CENPI 6571
NEK6 6528
CNTRL 6435
CSNK1E 6429
CEP63 6336
KNL1 6300
YWHAG 6286
AKAP9 6242
CDC20 6096
PCM1 5901
PCNT 5894
PDS5A 5785
XPO1 5625
CENPQ 5514
BUB3 5458
CEP250 5449
CEP135 5383
ERCC6L 5156
ALMS1 5123
MAPRE1 5048
NDE1 4928
DSN1 4816
NUP37 4625
CEP41 4601
NEK7 4564
KIF2A 4530
CEP290 4523
TAOK1 4480
SEH1L 4433
PPP2R5A 4400
PLK4 4324
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
CEP43 4210
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
NME7 3870
SKA1 3729
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
RAD21 3358
WAPL 3203
PLK1 3164
SGO2 3092
NEK2 3008
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
CEP164 2634
SPC25 2593
PPP2R5B 2592
NUP85 2385
HDAC8 2302
NDEL1 2105
PDS5B 2055
STAG1 1913
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
OFD1 1761
HAUS5 1667
NEK9 1631
DYNLL1 1561
HAUS6 1519
CEP78 1504
YWHAE 1494
CENPT 1162
RANBP2 1105
MIS12 1040
CEP192 984
CDK5RAP2 958
SMC2 946
B9D2 872
SMC1A 853
HSP90AA1 820
NUMA1 790
TUBG2 726
CEP76 490
CEP57 474
CETN2 224
SMC3 116
CEP72 -71
TUBB4B -239
SEC13 -240
MZT2A -357
NCAPD2 -396
CSNK2A1 -543
TUBGCP6 -558
PMF1 -611
CENPJ -806
HAUS3 -853
DYNC1H1 -1028
TUBGCP2 -1103
ACTR1A -1197
DCTN3 -1385
MZT2B -1440
PPP1CC -1467
DYNC1I1 -1561
SDCCAG8 -1729
NUP43 -1806
HAUS7 -1810
TUBA4A -1872
MAD1L1 -1976
PPP2R5E -2059
TUBB -2087
SSNA1 -2131
CSNK2B -2342
DCTN2 -2463
CEP131 -2518
HAUS1 -2630
HAUS2 -3059
ODF2 -3131
HAUS4 -3269
RCC2 -3305
EML4 -3573
NUP133 -3621
INCENP -4011
CSNK2A2 -4159
PPP2R5D -4551
TUBG1 -4887
RPS27 -5510
RANGAP1 -5521
HAUS8 -5594
NUDC -5900
DCTN1 -6110
NUP98 -6316
CSNK1D -6568
DYNLL2 -6837
PPP2R1A -7410
PRKACA -7564
PRKAR2B -8427


Resolution of Sister Chromatid Cohesion

Resolution of Sister Chromatid Cohesion
1059
set Resolution of Sister Chromatid Cohesion
setSize 104
pANOVA 7.24e-13
s.dist 0.407
p.adjustANOVA 6.96e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CDK1 8482
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
CENPO 8144
SPC24 8118
CENPP 7938

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CDK1 8482
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CDCA5 7644
CENPN 7635
ZWILCH 7311
CENPM 7233
NUP107 7149
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
CENPI 6571
KNL1 6300
CDC20 6096
PDS5A 5785
XPO1 5625
CENPQ 5514
BUB3 5458
ERCC6L 5156
MAPRE1 5048
NDE1 4928
DSN1 4816
NUP37 4625
KIF2A 4530
TAOK1 4480
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
SKA1 3729
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
RAD21 3358
WAPL 3203
PLK1 3164
SGO2 3092
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
HDAC8 2302
NDEL1 2105
PDS5B 2055
STAG1 1913
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
DYNLL1 1561
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
SMC1A 853
SMC3 116
SEC13 -240
PMF1 -611
DYNC1H1 -1028
PPP1CC -1467
DYNC1I1 -1561
NUP43 -1806
MAD1L1 -1976
PPP2R5E -2059
RCC2 -3305
NUP133 -3621
INCENP -4011
PPP2R5D -4551
RPS27 -5510
RANGAP1 -5521
NUDC -5900
NUP98 -6316
DYNLL2 -6837
PPP2R1A -7410


Role of LAT2/NTAL/LAB on calcium mobilization

Role of LAT2/NTAL/LAB on calcium mobilization
1071
set Role of LAT2/NTAL/LAB on calcium mobilization
setSize 42
pANOVA 9.97e-13
s.dist -0.636
p.adjustANOVA 8.99e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
IGKV3-15 -7850
IGLV1-44 -7694
SYK -7360
IGHV3-33 -6656
GAB2 -4908
GRB2 -4777
IGKV1-33 -2600
PIK3R2 -1500
SOS1 -829
LYN 2420
PDPK1 4887
SHC1 5065
LAT2 5318
PIK3CA 6452
PIK3CB 7464


Separation of Sister Chromatids

Separation of Sister Chromatids
1129
set Separation of Sister Chromatids
setSize 167
pANOVA 1.41e-11
s.dist 0.303
p.adjustANOVA 1.19e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
UBE2C 7882

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
UBE2C 7882
CENPA 7870
CDCA5 7644
CENPN 7635
ZWILCH 7311
PSMA5 7283
CENPM 7233
UBE2D1 7209
NUP107 7149
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
CENPI 6571
PSMD10 6444
KNL1 6300
ANAPC5 6110
CDC20 6096
ESPL1 5967
PDS5A 5785
XPO1 5625
PSMD14 5533
CENPQ 5514
ANAPC10 5493
BUB3 5458
PSMA2 5379
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
MAPRE1 5048
NDE1 4928
PSMD1 4898
DSN1 4816
ANAPC15 4796
PSMD12 4794
NUP37 4625
PSMC6 4558
KIF2A 4530
TAOK1 4480
PSME4 4470
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
PSMB4 3958
PSMB7 3904
CENPH 3875
PSMD11 3785
SKA1 3729
CLASP2 3637
PSME2 3582
PPP2R5C 3488
PSMD7 3466
CKAP5 3402
SEM1 3400
RAD21 3358
PSMA4 3210
WAPL 3203
PLK1 3164
PSMD9 3119
SGO2 3092
PSMA7 2958
PPP2CB 2822
CLIP1 2815
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
PSMA6 2325
HDAC8 2302
PSMB1 2193
NDEL1 2105
PDS5B 2055
STAG1 1913
CENPL 1908
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
PSMB5 1588
DYNLL1 1561
UBB 1263
ANAPC11 1164
CENPT 1162
PSME3 1142
RANBP2 1105
MIS12 1040
B9D2 872
SMC1A 853
PSMB2 809
PSMB3 777
PSMC2 361
SMC3 116
SEC13 -240
ANAPC7 -246
PSMA3 -465
PSMD2 -498
UBC -514
PMF1 -611
PSMD8 -867
PSMD5 -915
DYNC1H1 -1028
ANAPC1 -1157
PSMD6 -1289
PSMD13 -1463
PPP1CC -1467
DYNC1I1 -1561
ANAPC2 -1671
CDC27 -1716
NUP43 -1806
CDC26 -1879
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
PSMC3 -2697
ANAPC16 -3165
PSMD4 -3294
RCC2 -3305
RPS27A -3448
NUP133 -3621
PSMC4 -3885
INCENP -4011
CDC23 -4123
PSMB8 -4218
UBA52 -4448
PSME1 -4498
PPP2R5D -4551
PSMD3 -4749
RPS27 -5510
RANGAP1 -5521
PSMB10 -5760
NUDC -5900
NUP98 -6316
DYNLL2 -6837
PSMB9 -6888
PPP2R1A -7410
PSMF1 -7531


Mitotic Spindle Checkpoint

Mitotic Spindle Checkpoint
704
set Mitotic Spindle Checkpoint
setSize 108
pANOVA 1.52e-11
s.dist 0.376
p.adjustANOVA 1.22e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
UBE2C 7882
CENPA 7870

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
UBE2C 7882
CENPA 7870
CENPN 7635
ZWILCH 7311
CENPM 7233
UBE2D1 7209
NUP107 7149
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
CENPI 6571
KNL1 6300
ANAPC5 6110
CDC20 6096
XPO1 5625
CENPQ 5514
ANAPC10 5493
BUB3 5458
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
MAPRE1 5048
NDE1 4928
DSN1 4816
ANAPC15 4796
NUP37 4625
KIF2A 4530
TAOK1 4480
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
SKA1 3729
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
PLK1 3164
SGO2 3092
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
NDEL1 2105
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
DYNLL1 1561
ANAPC11 1164
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
SEC13 -240
ANAPC7 -246
PMF1 -611
DYNC1H1 -1028
ANAPC1 -1157
PPP1CC -1467
DYNC1I1 -1561
ANAPC2 -1671
CDC27 -1716
NUP43 -1806
CDC26 -1879
MAD1L1 -1976
PPP2R5E -2059
ANAPC16 -3165
RCC2 -3305
NUP133 -3621
INCENP -4011
CDC23 -4123
PPP2R5D -4551
RPS27 -5510
RANGAP1 -5521
NUDC -5900
NUP98 -6316
DYNLL2 -6837
PPP2R1A -7410


Mitotic Anaphase

Mitotic Anaphase
698
set Mitotic Anaphase
setSize 222
pANOVA 2.06e-11
s.dist 0.261
p.adjustANOVA 1.54e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
CDK1 8482
TUBB1 8440
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
CDK1 8482
TUBB1 8440
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
CENPO 8144
RCC1 8127
SPC24 8118
CENPP 7938
UBE2C 7882
CENPA 7870
CDCA5 7644
CENPN 7635
ZWILCH 7311
PSMA5 7283
CENPM 7233
UBE2D1 7209
NUP107 7149
ANKLE2 7114
CENPK 7060
TUBA1A 6985
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
CENPI 6571
PSMD10 6444
CC2D1B 6434
KNL1 6300
VRK1 6125
ANAPC5 6110
NUP58 6104
CDC20 6096
ESPL1 5967
PDS5A 5785
XPO1 5625
PSMD14 5533
CENPQ 5514
ANAPC10 5493
BUB3 5458
VRK2 5417
PSMA2 5379
LEMD3 5367
KPNB1 5308
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
MAPRE1 5048
LMNA 5022
NDE1 4928
PSMD1 4898
DSN1 4816
ANAPC15 4796
PSMD12 4794
NUP37 4625
PSMC6 4558
KIF2A 4530
TAOK1 4480
PSME4 4470
SEH1L 4433
PPP2R5A 4400
RAN 4331
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
PSMB4 3958
TNPO1 3915
PSMB7 3904
CENPH 3875
PSMD11 3785
SKA1 3729
CLASP2 3637
PSME2 3582
PPP2R5C 3488
PPP2R2A 3477
PSMD7 3466
CKAP5 3402
SEM1 3400
RAD21 3358
PSMA4 3210
WAPL 3203
PLK1 3164
PSMD9 3119
SGO2 3092
TUBA1C 3049
PSMA7 2958
CHMP3 2956
TUBB2A 2864
PPP2CB 2822
CLIP1 2815
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
LBR 2457
NUP85 2385
PSMA6 2325
HDAC8 2302
SUMO1 2289
PSMB1 2193
NDEL1 2105
PDS5B 2055
STAG1 1913
CENPL 1908
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
PSMB5 1588
DYNLL1 1561
NUP205 1456
UBB 1263
ANAPC11 1164
CENPT 1162
PSME3 1142
RANBP2 1105
MIS12 1040
B9D2 872
SMC1A 853
PSMB2 809
PSMB3 777
NUP155 640
TUBA1B 379
PSMC2 361
SMC3 116
TUBB4B -239
SEC13 -240
ANAPC7 -246
EMD -259
PSMA3 -465
PSMD2 -498
UBC -514
PMF1 -611
CHMP2B -785
PSMD8 -867
PSMD5 -915
NDC1 -928
DYNC1H1 -1028
ANAPC1 -1157
PSMD6 -1289
PSMD13 -1463
PPP1CC -1467
DYNC1I1 -1561
ANAPC2 -1671
CDC27 -1716
NUP43 -1806
TUBA4A -1872
CDC26 -1879
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
NUP62 -2277
PSMC3 -2697
NUP54 -2777
NUP35 -2799
TUBB6 -2838
LEMD2 -3149
ANAPC16 -3165
CHMP4B -3274
PSMD4 -3294
RCC2 -3305
CHMP6 -3324
BANF1 -3381
RPS27A -3448
CHMP4A -3463
SPAST -3529
TMPO -3596
NUP93 -3615
NUP133 -3621
CHMP2A -3676
PSMC4 -3885
NUP188 -3894
UBE2I -3998
INCENP -4011
CDC23 -4123
IST1 -4205
PSMB8 -4218
UBA52 -4448
PSME1 -4498
PPP2R5D -4551
TUBB2B -4592
PSMD3 -4749
SIRT2 -5022
POM121 -5296
RPS27 -5510
RANGAP1 -5521
PSMB10 -5760
NUDC -5900
CHMP7 -6046
NUP98 -6316
VPS4A -6410
TUBAL3 -6418
DYNLL2 -6837
PSMB9 -6888
PPP2R1A -7410
PSMF1 -7531


Mitotic Metaphase and Anaphase

Mitotic Metaphase and Anaphase
701
set Mitotic Metaphase and Anaphase
setSize 223
pANOVA 2.13e-11
s.dist 0.26
p.adjustANOVA 1.54e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
CDK1 8482
TUBB1 8440
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
TUBA8 8905
NUF2 8902
TUBB3 8889
LMNB1 8850
KIF18A 8767
BUB1B 8748
BIRC5 8710
UBE2S 8700
KNTC1 8660
BUB1 8578
MAD2L1 8490
CDK1 8482
TUBB1 8440
PTTG1 8374
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
CENPO 8144
RCC1 8127
SPC24 8118
CENPP 7938
UBE2C 7882
CENPA 7870
CDCA5 7644
CENPN 7635
ZWILCH 7311
PSMA5 7283
CENPM 7233
UBE2D1 7209
NUP107 7149
ANKLE2 7114
CENPK 7060
TUBA1A 6985
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
STAG2 6829
CENPI 6571
PSMD10 6444
CC2D1B 6434
KNL1 6300
VRK1 6125
ANAPC5 6110
NUP58 6104
CDC20 6096
ESPL1 5967
PDS5A 5785
XPO1 5625
PSMD14 5533
CENPQ 5514
ANAPC10 5493
BUB3 5458
VRK2 5417
PSMA2 5379
LEMD3 5367
KPNB1 5308
UBE2E1 5188
ANAPC4 5178
ERCC6L 5156
MAPRE1 5048
LMNA 5022
NDE1 4928
PSMD1 4898
DSN1 4816
ANAPC15 4796
PSMD12 4794
NUP37 4625
PSMC6 4558
KIF2A 4530
TAOK1 4480
PSME4 4470
SEH1L 4433
PPP2R5A 4400
RAN 4331
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PSMC1 4201
CDC16 4138
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
PSMB4 3958
TNPO1 3915
PSMB7 3904
CENPH 3875
PSMD11 3785
SKA1 3729
CLASP2 3637
PSME2 3582
PPP2R5C 3488
PPP2R2A 3477
PSMD7 3466
CKAP5 3402
SEM1 3400
RAD21 3358
PSMA4 3210
WAPL 3203
PLK1 3164
PSMD9 3119
SGO2 3092
TUBA1C 3049
PSMA7 2958
CHMP3 2956
TUBB2A 2864
PPP2CB 2822
CLIP1 2815
NUP160 2749
PSMB6 2743
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
LBR 2457
NUP85 2385
PSMA6 2325
HDAC8 2302
SUMO1 2289
PSMB1 2193
NDEL1 2105
PDS5B 2055
STAG1 1913
CENPL 1908
PSMA1 1881
NSL1 1865
CLASP1 1830
SKA2 1817
PSMB5 1588
DYNLL1 1561
NUP205 1456
UBB 1263
ANAPC11 1164
CENPT 1162
PSME3 1142
RANBP2 1105
MIS12 1040
B9D2 872
SMC1A 853
PSMB2 809
PSMB3 777
FBXO5 650
NUP155 640
TUBA1B 379
PSMC2 361
SMC3 116
TUBB4B -239
SEC13 -240
ANAPC7 -246
EMD -259
PSMA3 -465
PSMD2 -498
UBC -514
PMF1 -611
CHMP2B -785
PSMD8 -867
PSMD5 -915
NDC1 -928
DYNC1H1 -1028
ANAPC1 -1157
PSMD6 -1289
PSMD13 -1463
PPP1CC -1467
DYNC1I1 -1561
ANAPC2 -1671
CDC27 -1716
NUP43 -1806
TUBA4A -1872
CDC26 -1879
MAD1L1 -1976
PSMC5 -2016
PPP2R5E -2059
NUP62 -2277
PSMC3 -2697
NUP54 -2777
NUP35 -2799
TUBB6 -2838
LEMD2 -3149
ANAPC16 -3165
CHMP4B -3274
PSMD4 -3294
RCC2 -3305
CHMP6 -3324
BANF1 -3381
RPS27A -3448
CHMP4A -3463
SPAST -3529
TMPO -3596
NUP93 -3615
NUP133 -3621
CHMP2A -3676
PSMC4 -3885
NUP188 -3894
UBE2I -3998
INCENP -4011
CDC23 -4123
IST1 -4205
PSMB8 -4218
UBA52 -4448
PSME1 -4498
PPP2R5D -4551
TUBB2B -4592
PSMD3 -4749
SIRT2 -5022
POM121 -5296
RPS27 -5510
RANGAP1 -5521
PSMB10 -5760
NUDC -5900
CHMP7 -6046
NUP98 -6316
VPS4A -6410
TUBAL3 -6418
DYNLL2 -6837
PSMB9 -6888
PPP2R1A -7410
PSMF1 -7531


Anti-inflammatory response favouring Leishmania parasite infection

Anti-inflammatory response favouring Leishmania parasite infection
76
set Anti-inflammatory response favouring Leishmania parasite infection
setSize 139
pANOVA 5.24e-11
s.dist -0.322
p.adjustANOVA 3.44e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
ADCYAP1 -9411
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
RAMP1 -9283
PTGER4 -9261
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
GGT5 -9213
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
VIPR1 -9147
IGLV1-40 -9126
GPBAR1 -9104

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
ADCYAP1 -9411
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
RAMP1 -9283
PTGER4 -9261
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
GGT5 -9213
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
VIPR1 -9147
IGLV1-40 -9126
GPBAR1 -9104
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
ADRB1 -8700
IGLV2-23 -8686
IGKC -8678
ADCY3 -8575
IGKV1D-39 -8562
ADORA2B -8481
IGHV4-59 -8467
PRKAR2B -8427
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
CD163 -8045
PTGIR -8002
ADRB2 -7962
ADCY5 -7933
IGKV3-15 -7850
LHCGR -7798
RAMP2 -7773
IGLV1-44 -7694
HRH2 -7637
PTGDR -7576
PRKACA -7564
SYK -7360
P2RY11 -7301
GNGT2 -7161
PTHLH -6909
IGHV3-33 -6656
VIPR2 -6275
GNG4 -6202
SRC -6078
GNB2 -6075
PRKAR1B -5421
RAMP3 -5372
AVPR2 -5330
CYSLTR1 -5278
MYH9 -5033
HCK -4732
PLCG2 -4620
IL6 -4501
PRKX -4247
ADORA2A -4174
GNG7 -4082
GNAI2 -4056
RHBDF2 -3922
GNG5 -3662
ADM2 -3576
GNAS -3127
IGKV1-33 -2600
GPR176 -2443
TSHR -2422
GNB1 -2386
CYSLTR2 -2219
ADCY4 -2065
GNAZ -1901
ADCY6 -1414
HTR7 -1166
CRHR2 -1041
FURIN -905
GNG12 -869
POMC -737
PRKAR2A -702
MAPK14 -684
GNB3 -618
GNB5 -175
ADCY9 90
GNG2 129
ITPR3 513
FCGR1A 592
PLCG1 819
PRKACB 1399
GNG11 1523
GLP2R 1600
PTGER2 1967
PTH1R 1988
AHCYL1 2038
GNAI3 2183
LYN 2420
HTR6 2477
CALCRL 2589
GIPR 2790
VIP 3041
CD3G 3144
GNAI1 3173
PRKAR1A 3292
CREB1 3548
ADAM17 4510
MC1R 4514
ADCY7 4611
GGT1 4644
GNB4 5446
GPR150 5728
ADCY1 5774
GNG10 5843
YES1 5910
GPR27 6118
DPEP2 7008
ADCYAP1R1 7028
CALM1 7072
PLK2 7416
FGR 7542
GPR84 7889
ADCY2 7892
ITPR2 8466
ITPR1 8491
IL10 8528
CD247 8946
ADM 9134


Leishmania parasite growth and survival

Leishmania parasite growth and survival
622
set Leishmania parasite growth and survival
setSize 139
pANOVA 5.24e-11
s.dist -0.322
p.adjustANOVA 3.44e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
ADCYAP1 -9411
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
RAMP1 -9283
PTGER4 -9261
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
GGT5 -9213
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
VIPR1 -9147
IGLV1-40 -9126
GPBAR1 -9104

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
ADCYAP1 -9411
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
RAMP1 -9283
PTGER4 -9261
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
GGT5 -9213
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
VIPR1 -9147
IGLV1-40 -9126
GPBAR1 -9104
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
ADRB1 -8700
IGLV2-23 -8686
IGKC -8678
ADCY3 -8575
IGKV1D-39 -8562
ADORA2B -8481
IGHV4-59 -8467
PRKAR2B -8427
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
CD163 -8045
PTGIR -8002
ADRB2 -7962
ADCY5 -7933
IGKV3-15 -7850
LHCGR -7798
RAMP2 -7773
IGLV1-44 -7694
HRH2 -7637
PTGDR -7576
PRKACA -7564
SYK -7360
P2RY11 -7301
GNGT2 -7161
PTHLH -6909
IGHV3-33 -6656
VIPR2 -6275
GNG4 -6202
SRC -6078
GNB2 -6075
PRKAR1B -5421
RAMP3 -5372
AVPR2 -5330
CYSLTR1 -5278
MYH9 -5033
HCK -4732
PLCG2 -4620
IL6 -4501
PRKX -4247
ADORA2A -4174
GNG7 -4082
GNAI2 -4056
RHBDF2 -3922
GNG5 -3662
ADM2 -3576
GNAS -3127
IGKV1-33 -2600
GPR176 -2443
TSHR -2422
GNB1 -2386
CYSLTR2 -2219
ADCY4 -2065
GNAZ -1901
ADCY6 -1414
HTR7 -1166
CRHR2 -1041
FURIN -905
GNG12 -869
POMC -737
PRKAR2A -702
MAPK14 -684
GNB3 -618
GNB5 -175
ADCY9 90
GNG2 129
ITPR3 513
FCGR1A 592
PLCG1 819
PRKACB 1399
GNG11 1523
GLP2R 1600
PTGER2 1967
PTH1R 1988
AHCYL1 2038
GNAI3 2183
LYN 2420
HTR6 2477
CALCRL 2589
GIPR 2790
VIP 3041
CD3G 3144
GNAI1 3173
PRKAR1A 3292
CREB1 3548
ADAM17 4510
MC1R 4514
ADCY7 4611
GGT1 4644
GNB4 5446
GPR150 5728
ADCY1 5774
GNG10 5843
YES1 5910
GPR27 6118
DPEP2 7008
ADCYAP1R1 7028
CALM1 7072
PLK2 7416
FGR 7542
GPR84 7889
ADCY2 7892
ITPR2 8466
ITPR1 8491
IL10 8528
CD247 8946
ADM 9134


EML4 and NUDC in mitotic spindle formation

EML4 and NUDC in mitotic spindle formation
338
set EML4 and NUDC in mitotic spindle formation
setSize 95
pANOVA 6.67e-11
s.dist 0.387
p.adjustANOVA 4.18e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
ZWILCH 7311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
ZWILCH 7311
CENPM 7233
NUP107 7149
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
CENPI 6571
NEK6 6528
KNL1 6300
CDC20 6096
XPO1 5625
CENPQ 5514
BUB3 5458
ERCC6L 5156
MAPRE1 5048
NDE1 4928
DSN1 4816
NUP37 4625
NEK7 4564
KIF2A 4530
TAOK1 4480
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
SKA1 3729
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
PLK1 3164
SGO2 3092
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
NDEL1 2105
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
NEK9 1631
DYNLL1 1561
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
SEC13 -240
PMF1 -611
DYNC1H1 -1028
PPP1CC -1467
DYNC1I1 -1561
NUP43 -1806
MAD1L1 -1976
PPP2R5E -2059
RCC2 -3305
EML4 -3573
NUP133 -3621
INCENP -4011
PPP2R5D -4551
RPS27 -5510
RANGAP1 -5521
NUDC -5900
NUP98 -6316
DYNLL2 -6837
PPP2R1A -7410


Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
72
set Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
setSize 91
pANOVA 9.23e-11
s.dist 0.393
p.adjustANOVA 5.33e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
ZWILCH 7311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
ZWILCH 7311
CENPM 7233
NUP107 7149
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
CENPI 6571
KNL1 6300
CDC20 6096
XPO1 5625
CENPQ 5514
BUB3 5458
ERCC6L 5156
MAPRE1 5048
NDE1 4928
DSN1 4816
NUP37 4625
KIF2A 4530
TAOK1 4480
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
SKA1 3729
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
PLK1 3164
SGO2 3092
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
NDEL1 2105
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
DYNLL1 1561
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
SEC13 -240
PMF1 -611
DYNC1H1 -1028
PPP1CC -1467
DYNC1I1 -1561
NUP43 -1806
MAD1L1 -1976
PPP2R5E -2059
RCC2 -3305
NUP133 -3621
INCENP -4011
PPP2R5D -4551
RPS27 -5510
RANGAP1 -5521
NUDC -5900
NUP98 -6316
DYNLL2 -6837
PPP2R1A -7410


Amplification of signal from the kinetochores

Amplification of signal from the kinetochores
73
set Amplification of signal from the kinetochores
setSize 91
pANOVA 9.23e-11
s.dist 0.393
p.adjustANOVA 5.33e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
ZWILCH 7311

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
ZWILCH 7311
CENPM 7233
NUP107 7149
CENPK 7060
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
CENPI 6571
KNL1 6300
CDC20 6096
XPO1 5625
CENPQ 5514
BUB3 5458
ERCC6L 5156
MAPRE1 5048
NDE1 4928
DSN1 4816
NUP37 4625
KIF2A 4530
TAOK1 4480
SEH1L 4433
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
SKA1 3729
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
PLK1 3164
SGO2 3092
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
NDEL1 2105
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
DYNLL1 1561
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
SEC13 -240
PMF1 -611
DYNC1H1 -1028
PPP1CC -1467
DYNC1I1 -1561
NUP43 -1806
MAD1L1 -1976
PPP2R5E -2059
RCC2 -3305
NUP133 -3621
INCENP -4011
PPP2R5D -4551
RPS27 -5510
RANGAP1 -5521
NUDC -5900
NUP98 -6316
DYNLL2 -6837
PPP2R1A -7410


Role of phospholipids in phagocytosis

Role of phospholipids in phagocytosis
1072
set Role of phospholipids in phagocytosis
setSize 58
pANOVA 1.12e-10
s.dist -0.49
p.adjustANOVA 6.19e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
IGKV3-15 -7850
IGLV1-44 -7694
SYK -7360
IGHV3-33 -6656
PLD3 -6310
PLCG2 -4620
IGKV1-33 -2600
PRKCD -2334
PIK3R2 -1500
PLA2G6 -865
PLD2 -850
PLD4 -577
ITPR3 513
PLD1 545
FCGR1A 592
PLCG1 819
AHCYL1 2038
PRKCE 2352
CD3G 3144
PLPP5 4414
PIK3CA 6452
PIK3CB 7464
PLPP4 8345
ITPR2 8466
ITPR1 8491
CD247 8946


FCGR3A-mediated IL10 synthesis

FCGR3A-mediated IL10 synthesis
381
set FCGR3A-mediated IL10 synthesis
setSize 70
pANOVA 1.62e-10
s.dist -0.442
p.adjustANOVA 8.67e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
ADCY3 -8575
IGKV1D-39 -8562
IGHV4-59 -8467
PRKAR2B -8427
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
ADCY5 -7933
IGKV3-15 -7850
IGLV1-44 -7694
PRKACA -7564
SYK -7360
IGHV3-33 -6656
SRC -6078
PRKAR1B -5421
HCK -4732
PLCG2 -4620
PRKX -4247
IGKV1-33 -2600
ADCY4 -2065
ADCY6 -1414
PRKAR2A -702
ADCY9 90
ITPR3 513
FCGR1A 592
PLCG1 819
PRKACB 1399
AHCYL1 2038
LYN 2420
CD3G 3144
PRKAR1A 3292
CREB1 3548
ADCY7 4611
ADCY1 5774
YES1 5910
CALM1 7072
FGR 7542
ADCY2 7892
ITPR2 8466
ITPR1 8491
IL10 8528
CD247 8946


Kinesins

Kinesins
611
set Kinesins
setSize 37
pANOVA 1.07e-09
s.dist 0.579
p.adjustANOVA 5.52e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
KIF26B 9084
KIF18B 9059
KIF21B 8890
KIFC1 8828
KIF20A 8808
RACGAP1 8791
KIF18A 8767
KIF5C 8611
KIF23 8565
KIF5A 8383
KIF3C 8350
KIFAP3 8251
KIF6 8035
KIF4A 7890
KIF21A 7552
KIF11 7079
CENPE 6840
KIF15 6806
KIF5B 6745
KIF9 6069

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KIF26B 9084
KIF18B 9059
KIF21B 8890
KIFC1 8828
KIF20A 8808
RACGAP1 8791
KIF18A 8767
KIF5C 8611
KIF23 8565
KIF5A 8383
KIF3C 8350
KIFAP3 8251
KIF6 8035
KIF4A 7890
KIF21A 7552
KIF11 7079
CENPE 6840
KIF15 6806
KIF5B 6745
KIF9 6069
KIF3A 6065
KIF1B 5795
KIF2A 4530
KLC2 4497
KIF2C 4231
KIF26A 4033
KIF1C 3459
KIF20B 3333
KIF13B 2458
KIF3B 2349
KLC1 1849
KIFC2 1421
KIF16B 427
KIF22 -103
KLC4 -111
KIF27 -2187
KIF19 -9121


Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
78
set Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
setSize 60
pANOVA 1.73e-09
s.dist -0.449
p.adjustANOVA 8.63e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHD -9093
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHD -9093
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
IGKV3-15 -7850
IGLV1-44 -7694
BLNK -7515
SYK -7360
IGHM -7037
IGHV3-33 -6656
ORAI1 -5240
GRB2 -4777
PLCG2 -4620
PIK3AP1 -3646
PTPN6 -2920
IGKV1-33 -2600
NCK1 -2177
SH3KBP1 -1297
CD79A -871
SOS1 -829
STIM1 12
ITPR3 513
BTK 1744
AHCYL1 2038
LYN 2420
BLK 2935
CD22 4869
ORAI2 5201
DAPP1 5670
CALM1 7072
TRPC1 7150
CD79B 8221
PIK3CD 8347
ITPR2 8466
ITPR1 8491


FCGR3A-mediated phagocytosis

FCGR3A-mediated phagocytosis
382
set FCGR3A-mediated phagocytosis
setSize 92
pANOVA 2.18e-09
s.dist -0.361
p.adjustANOVA 9.83e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
ARPC1A -7978
IGKV3-15 -7850
IGLV1-44 -7694
WASF1 -7416
SYK -7360
WIPF3 -6964
MAPK3 -6930
IGHV3-33 -6656
WAS -6425
SRC -6078
WASF2 -6027
BAIAP2 -5727
VAV2 -5663
ABL1 -5571
RAC1 -5383
ELMO1 -5355
MYH9 -5033
WASF3 -4974
NCKAP1L -4809
GRB2 -4777
HCK -4732
PTK2 -4681
MYO1C -3516
ARPC4 -3439
ACTB -3297
IGKV1-33 -2600
WIPF2 -2197
NCKIPSD -2186
NCK1 -2177
BRK1 -1584
MYH2 -1279
CRK -1031
MYO9B -1009
ARPC1B -597
CDC42 -229
ACTG1 355
ELMO2 1306
DOCK1 1351
BTK 1744
LYN 2420
CYFIP1 2740
ARPC5 2999
CD3G 3144
WASL 3461
MYO5A 3735
ARPC3 4051
MAPK1 4733
ARPC2 5282
YES1 5910
ABI2 6106
NCKAP1 6268
CYFIP2 6304
WIPF1 6477
ACTR2 6719
VAV3 7268
ACTR3 7347
FGR 7542
ABI1 8160
MYO10 8927
CD247 8946


Leishmania phagocytosis

Leishmania phagocytosis
623
set Leishmania phagocytosis
setSize 92
pANOVA 2.18e-09
s.dist -0.361
p.adjustANOVA 9.83e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
ARPC1A -7978
IGKV3-15 -7850
IGLV1-44 -7694
WASF1 -7416
SYK -7360
WIPF3 -6964
MAPK3 -6930
IGHV3-33 -6656
WAS -6425
SRC -6078
WASF2 -6027
BAIAP2 -5727
VAV2 -5663
ABL1 -5571
RAC1 -5383
ELMO1 -5355
MYH9 -5033
WASF3 -4974
NCKAP1L -4809
GRB2 -4777
HCK -4732
PTK2 -4681
MYO1C -3516
ARPC4 -3439
ACTB -3297
IGKV1-33 -2600
WIPF2 -2197
NCKIPSD -2186
NCK1 -2177
BRK1 -1584
MYH2 -1279
CRK -1031
MYO9B -1009
ARPC1B -597
CDC42 -229
ACTG1 355
ELMO2 1306
DOCK1 1351
BTK 1744
LYN 2420
CYFIP1 2740
ARPC5 2999
CD3G 3144
WASL 3461
MYO5A 3735
ARPC3 4051
MAPK1 4733
ARPC2 5282
YES1 5910
ABI2 6106
NCKAP1 6268
CYFIP2 6304
WIPF1 6477
ACTR2 6719
VAV3 7268
ACTR3 7347
FGR 7542
ABI1 8160
MYO10 8927
CD247 8946


Parasite infection

Parasite infection
831
set Parasite infection
setSize 92
pANOVA 2.18e-09
s.dist -0.361
p.adjustANOVA 9.83e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
ARPC1A -7978
IGKV3-15 -7850
IGLV1-44 -7694
WASF1 -7416
SYK -7360
WIPF3 -6964
MAPK3 -6930
IGHV3-33 -6656
WAS -6425
SRC -6078
WASF2 -6027
BAIAP2 -5727
VAV2 -5663
ABL1 -5571
RAC1 -5383
ELMO1 -5355
MYH9 -5033
WASF3 -4974
NCKAP1L -4809
GRB2 -4777
HCK -4732
PTK2 -4681
MYO1C -3516
ARPC4 -3439
ACTB -3297
IGKV1-33 -2600
WIPF2 -2197
NCKIPSD -2186
NCK1 -2177
BRK1 -1584
MYH2 -1279
CRK -1031
MYO9B -1009
ARPC1B -597
CDC42 -229
ACTG1 355
ELMO2 1306
DOCK1 1351
BTK 1744
LYN 2420
CYFIP1 2740
ARPC5 2999
CD3G 3144
WASL 3461
MYO5A 3735
ARPC3 4051
MAPK1 4733
ARPC2 5282
YES1 5910
ABI2 6106
NCKAP1 6268
CYFIP2 6304
WIPF1 6477
ACTR2 6719
VAV3 7268
ACTR3 7347
FGR 7542
ABI1 8160
MYO10 8927
CD247 8946


RHO GTPases Activate Formins

RHO GTPases Activate Formins
918
set RHO GTPases Activate Formins
setSize 118
pANOVA 2.74e-09
s.dist 0.317
p.adjustANOVA 1.2e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
DIAPH3 8870
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
DIAPH3 8870
KIF18A 8767
BUB1B 8748
BIRC5 8710
KNTC1 8660
BUB1 8578
MAD2L1 8490
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
CENPO 8144
SPC24 8118
CENPP 7938
CENPA 7870
CENPN 7635
FMNL2 7383
ITGB1 7377
ZWILCH 7311
CENPM 7233
NUP107 7149
CENPK 7060
DAAM1 7013
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CENPE 6840
SRGAP2 6649
CENPI 6571
KNL1 6300
CDC20 6096
XPO1 5625
CENPQ 5514
BUB3 5458
ERCC6L 5156
MAPRE1 5048
FMNL3 5046
DVL3 4992
NDE1 4928
DSN1 4816
NUP37 4625
KIF2A 4530
TAOK1 4480
SEH1L 4433
PFN2 4401
PPP2R5A 4400
AHCTF1 4308
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
SKA1 3729
SRF 3647
CLASP2 3637
PPP2R5C 3488
CKAP5 3402
PLK1 3164
SGO2 3092
RHOD 2941
PPP2CB 2822
CLIP1 2815
NUP160 2749
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
NUP85 2385
NDEL1 2105
CENPL 1908
NSL1 1865
CLASP1 1830
SKA2 1817
SCAI 1620
DYNLL1 1561
DIAPH1 1251
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
ACTG1 355
PFN1 246
EVL 114
CDC42 -229
SEC13 -240
PMF1 -611
RHOC -685
DYNC1H1 -1028
PPP1CC -1467
DYNC1I1 -1561
NUP43 -1806
RHOA -1834
MAD1L1 -1976
PPP2R5E -2059
DVL1 -2189
ACTB -3297
RCC2 -3305
NUP133 -3621
INCENP -4011
DVL2 -4322
PPP2R5D -4551
RHOB -4591
RAC1 -5383
RPS27 -5510
RANGAP1 -5521
NUDC -5900
FMNL1 -6008
SRC -6078
NUP98 -6316
DYNLL2 -6837
PPP2R1A -7410
DIAPH2 -7909
MRTFA -8646


rRNA processing

rRNA processing
1434
set rRNA processing
setSize 214
pANOVA 4.56e-09
s.dist -0.233
p.adjustANOVA 1.94e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-ATP8 -9166
UTP14C -9087
NOL6 -8942
NOP2 -8813
NOL9 -8705
RPS26 -8665
EXOSC6 -8570
MRM1 -8506
TBL3 -8403
DHX37 -8228
MT-ND4L -7919
WDR46 -7843
RPS4X -7595
BYSL -7533
IMP3 -7513
PES1 -7460
RCL1 -7407
NOB1 -7220
EXOSC10 -7045
PWP2 -6950

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP8 -9166
UTP14C -9087
NOL6 -8942
NOP2 -8813
NOL9 -8705
RPS26 -8665
EXOSC6 -8570
MRM1 -8506
TBL3 -8403
DHX37 -8228
MT-ND4L -7919
WDR46 -7843
RPS4X -7595
BYSL -7533
IMP3 -7513
PES1 -7460
RCL1 -7407
NOB1 -7220
EXOSC10 -7045
PWP2 -6950
RPS14 -6788
PELP1 -6728
RPL28 -6570
CSNK1D -6568
FTSJ3 -6378
RPL13 -6363
RPL8 -6361
FBL -6190
NAT10 -6107
RPL36 -6030
UTP14A -5991
TRMT112 -5960
RPL39 -5932
RRP9 -5902
RPLP2 -5890
DDX49 -5888
RPP25 -5836
RRP36 -5731
MT-ATP6 -5677
IMP4 -5590
RPS18 -5579
EXOSC2 -5539
MT-ND2 -5530
RPL11 -5519
RPS27 -5510
MT-ND1 -5503
RPL32 -5488
RPS28 -5453
BOP1 -5425
WDR43 -5402
RPL24 -5320
MT-CO3 -5170
RPS8 -5159
TSR3 -5152
MT-ND5 -5101
RPL35 -5082
RPS23 -4831
RPL37 -4759
MRM2 -4745
RPS20 -4706
RPL18 -4688
NHP2 -4544
RPL30 -4524
HSD17B10 -4465
RPL3 -4463
UBA52 -4448
WDR3 -4396
RPL3L -4369
WDR36 -4312
RPS11 -4244
RPS15 -4222
DIMT1 -4135
MTERF4 -4109
MT-ND4 -4092
MRM3 -4089
RPL7A -4057
RPL27A -4009
WDR18 -4005
RPS21 -4002
RPL29 -3938
RPS25 -3919
MTREX -3902
RPL13A -3862
RPL35A -3799
FAU -3776
RPL38 -3763
RPL10A -3747
RPL31 -3745
RPS5 -3743
C1D -3679
RPLP1 -3664
RPL12 -3595
RPL18A -3559
RPS6 -3486
RPL5 -3471
RPS27A -3448
RPS17 -3388
RPL23 -3320
EXOSC3 -3289
UTP18 -3266
RPL15 -3201
LAS1L -2979
RPS24 -2970
RPL34 -2834
EXOSC8 -2781
RPL19 -2757
RPL7 -2750
RPL37A -2738
ISG20L2 -2719
RPS3 -2711
RPL26L1 -2708
RPL23A -2704
RPL22 -2693
RPS15A -2633
RPS29 -2569
RPL6 -2567
RPL10 -2555
NOL11 -2537
RBM28 -2502
RIOK2 -2491
MT-CYB -2407
RPL27 -2349
NCL -2347
RRP1 -2302
RPS12 -2296
RPL21 -2283
RPL4 -2274
BMS1 -2254
SENP3 -2221
EBNA1BP2 -2139
EXOSC5 -2136
UTP3 -2123
LTV1 -2108
PDCD11 -2104
NOL12 -2047
NOP56 -2046
EXOSC4 -2025
RPP38 -1963
RPS10 -1954
RPL17 -1931
RPL41 -1724
UTP11 -1630
DKC1 -1526
MT-ND3 -1497
RPS3A -1430
MT-CO1 -1345
EXOSC7 -1306
GAR1 -1186
UTP4 -1134
RPL26 -1088
RPL14 -1062
RPS19 -981
RPP40 -945
TEX10 -885
MT-CO2 -845
RPS7 -815
SNU13 -789
TRMT10C -788
WDR12 -446
RPS4Y1 -397
RPL36A -308
HEATR1 -306
THUMPD1 -225
XRN2 -191
EMG1 117
RPL39L 144
RPS16 184
NIP7 251
RRP7A 253
MPHOSPH10 364
DIS3 759
UTP20 868
NOC4L 947
RPL36AL 1042
EXOSC1 1065
RPS13 1175
RPP14 1220
UTP25 1520
NSUN4 1527
PNO1 1604
RPS9 1610
RPP30 1650
FCF1 1943
RPLP0 1980
NOP14 2357
RIOK3 2668
RPP21 2679
TSR1 2680
KRR1 2808
RPS2 2979
MPHOSPH6 2983
ELAC2 3112
NOP58 3290
RIOK1 3533
PRORP 3560
DCAF13 3797
DDX52 3821
DDX21 4061
UTP6 4265
DDX47 4724
NOP10 4819
RPL9 6398
CSNK1E 6429
ERI1 6681
RPL22L1 6714
GNL3 6734
TFB1M 7001
RPS27L 7491
EXOSC9 7805
UTP15 7916
MT-RNR1 8165
RPSA 8258
WDR75 8418
MT-RNR2 8569


Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation
1031
set Regulation of actin dynamics for phagocytic cup formation
setSize 94
pANOVA 4.84e-09
s.dist -0.349
p.adjustANOVA 2e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
ARPC1A -7978
IGKV3-15 -7850
IGLV1-44 -7694
NF2 -7562
WASF1 -7416
SYK -7360
WIPF3 -6964
MAPK3 -6930
IGHV3-33 -6656
WAS -6425
WASF2 -6027
BAIAP2 -5727
VAV2 -5663
ABL1 -5571
RAC1 -5383
ELMO1 -5355
MYH9 -5033
WASF3 -4974
NCKAP1L -4809
GRB2 -4777
PTK2 -4681
MYO1C -3516
ARPC4 -3439
ACTB -3297
IGKV1-33 -2600
WIPF2 -2197
NCKIPSD -2186
NCK1 -2177
BRK1 -1584
MYH2 -1279
CRK -1031
MYO9B -1009
ARPC1B -597
CDC42 -229
HSP90AB1 348
ACTG1 355
FCGR1A 592
HSP90AA1 820
ELMO2 1306
DOCK1 1351
BTK 1744
CFL1 2483
CYFIP1 2740
PAK1 2998
ARPC5 2999
CD3G 3144
WASL 3461
MYO5A 3735
ARPC3 4051
MAPK1 4733
ARPC2 5282
ABI2 6106
NCKAP1 6268
CYFIP2 6304
WIPF1 6477
ACTR2 6719
VAV3 7268
ACTR3 7347
LIMK1 7568
ABI1 8160
MYO10 8927
CD247 8946


FCERI mediated MAPK activation

FCERI mediated MAPK activation
378
set FCERI mediated MAPK activation
setSize 58
pANOVA 1.7e-08
s.dist -0.428
p.adjustANOVA 6.68e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
IGKV3-15 -7850
IGLV1-44 -7694
MAPK10 -7411
SYK -7360
MAP2K7 -6956
MAPK3 -6930
IGHV3-33 -6656
MAP3K1 -6600
VAV2 -5663
RAC1 -5383
GRB2 -4777
PLCG2 -4620
LCP2 -4226
IGKV1-33 -2600
SOS1 -829
PLCG1 819
GRAP2 1296
PAK2 1875
HRAS 1884
MAP2K4 2008
LYN 2420
PAK1 2998
MAPK8 4545
MAPK1 4733
SHC1 5065
MAPK9 5952
LAT 6051
KRAS 6427
VAV3 7268
JUN 7366
NRAS 8381
FOS 9012


Leishmania infection

Leishmania infection
621
set Leishmania infection
setSize 220
pANOVA 1.71e-08
s.dist -0.221
p.adjustANOVA 6.68e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
C3 -9494
IGKV3-11 -9413
ADCYAP1 -9411
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
RAMP1 -9283
PTGER4 -9261
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
GGT5 -9213
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
VIPR1 -9147
TXNIP -9143

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C3 -9494
IGKV3-11 -9413
ADCYAP1 -9411
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
RAMP1 -9283
PTGER4 -9261
IGLC2 -9238
ADCY8 -9237
IGLV3-25 -9227
GGT5 -9213
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
VIPR1 -9147
TXNIP -9143
IGLV1-40 -9126
GPBAR1 -9104
IGLV2-11 -9099
IGHG2 -9096
FZD7 -9077
C3AR1 -9074
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
ADRB1 -8700
IGLV2-23 -8686
IGKC -8678
ADCY3 -8575
IGKV1D-39 -8562
ADORA2B -8481
IGHV4-59 -8467
VAV1 -8460
PRKAR2B -8427
NOXA1 -8368
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
CD163 -8045
PTGIR -8002
ARPC1A -7978
ADRB2 -7962
ADCY5 -7933
IGKV3-15 -7850
LHCGR -7798
RAMP2 -7773
IGLV1-44 -7694
HRH2 -7637
PTGDR -7576
PRKACA -7564
P2RX4 -7557
PYCARD -7529
WASF1 -7416
SYK -7360
P2RY11 -7301
GNGT2 -7161
WIPF3 -6964
MAPK3 -6930
PTHLH -6909
IGHV3-33 -6656
WAS -6425
VIPR2 -6275
GNG4 -6202
SRC -6078
GNB2 -6075
WASF2 -6027
P2RX7 -5942
BAIAP2 -5727
VAV2 -5663
ABL1 -5571
PRKAR1B -5421
RAC1 -5383
RAMP3 -5372
ELMO1 -5355
AVPR2 -5330
CYSLTR1 -5278
CTSG -5055
MYH9 -5033
WASF3 -4974
CASP1 -4866
NCKAP1L -4809
GRB2 -4777
HCK -4732
PTK2 -4681
PLCG2 -4620
IL6 -4501
RELA -4481
DVL2 -4322
CYBA -4304
PRKX -4247
ADORA2A -4174
GNG7 -4082
GNAI2 -4056
RHBDF2 -3922
GNG5 -3662
ADM2 -3576
MYO1C -3516
ARPC4 -3439
ACTB -3297
GNAS -3127
NT5E -3023
IL18 -2914
IGKV1-33 -2600
GPR176 -2443
TSHR -2422
GNB1 -2386
CYSLTR2 -2219
WIPF2 -2197
DVL1 -2189
NCKIPSD -2186
NCK1 -2177
ADCY4 -2065
GNAZ -1901
BRK1 -1584
ADCY6 -1414
MYH2 -1279
ENTPD1 -1196
HTR7 -1166
CRHR2 -1041
CRK -1031
MYO9B -1009
FURIN -905
GNG12 -869
POMC -737
PRKAR2A -702
MAPK14 -684
GNB3 -618
ARPC1B -597
CDC42 -229
GNB5 -175
ADCY9 90
GNG2 129
GSDMD 182
HSP90AB1 348
ACTG1 355
ITPR3 513
FCGR1A 592
PLCG1 819
ELMO2 1306
DOCK1 1351
PRKACB 1399
GNG11 1523
GLP2R 1600
BTK 1744
PSTPIP1 1861
PTGER2 1967
PTH1R 1988
SUGT1 1995
AHCYL1 2038
GNAI3 2183
LYN 2420
HTR6 2477
CALCRL 2589
NFKB1 2665
CYFIP1 2740
GIPR 2790
ARPC5 2999
VIP 3041
CD3G 3144
GNAI1 3173
PRKAR1A 3292
WASL 3461
CREB1 3548
MYO5A 3735
ARPC3 4051
TXN 4421
ADAM17 4510
MC1R 4514
MAPK8 4545
ADCY7 4611
NLRP3 4618
GGT1 4644
MAPK1 4733
DVL3 4992
HMOX1 5160
ARPC2 5282
GNB4 5446
GPR150 5728
ADCY1 5774
GNG10 5843
YES1 5910
ABI2 6106
GPR27 6118
NCKAP1 6268
CYFIP2 6304
WIPF1 6477
NFKB2 6494
ACTR2 6719
ENTPD5 6749
DPEP2 7008
ADCYAP1R1 7028
CALM1 7072
VAV3 7268
ACTR3 7347
JUN 7366
PLK2 7416
FGR 7542
GPR84 7889
ADCY2 7892
ABI1 8160
ITPR2 8466
ITPR1 8491
IL10 8528
MEFV 8723
WNT5A 8754
MYO10 8927
CD247 8946
ADM 9134
IL1B 9161


rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
1436
set rRNA processing in the nucleus and cytosol
setSize 190
pANOVA 2.1e-08
s.dist -0.236
p.adjustANOVA 7.97e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
UTP14C -9087
NOL6 -8942
NOP2 -8813
NOL9 -8705
RPS26 -8665
EXOSC6 -8570
TBL3 -8403
DHX37 -8228
WDR46 -7843
RPS4X -7595
BYSL -7533
IMP3 -7513
PES1 -7460
RCL1 -7407
NOB1 -7220
EXOSC10 -7045
PWP2 -6950
RPS14 -6788
PELP1 -6728
RPL28 -6570

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UTP14C -9087
NOL6 -8942
NOP2 -8813
NOL9 -8705
RPS26 -8665
EXOSC6 -8570
TBL3 -8403
DHX37 -8228
WDR46 -7843
RPS4X -7595
BYSL -7533
IMP3 -7513
PES1 -7460
RCL1 -7407
NOB1 -7220
EXOSC10 -7045
PWP2 -6950
RPS14 -6788
PELP1 -6728
RPL28 -6570
CSNK1D -6568
FTSJ3 -6378
RPL13 -6363
RPL8 -6361
FBL -6190
NAT10 -6107
RPL36 -6030
UTP14A -5991
TRMT112 -5960
RPL39 -5932
RRP9 -5902
RPLP2 -5890
DDX49 -5888
RPP25 -5836
RRP36 -5731
IMP4 -5590
RPS18 -5579
EXOSC2 -5539
RPL11 -5519
RPS27 -5510
RPL32 -5488
RPS28 -5453
BOP1 -5425
WDR43 -5402
RPL24 -5320
RPS8 -5159
TSR3 -5152
RPL35 -5082
RPS23 -4831
RPL37 -4759
RPS20 -4706
RPL18 -4688
NHP2 -4544
RPL30 -4524
RPL3 -4463
UBA52 -4448
WDR3 -4396
RPL3L -4369
WDR36 -4312
RPS11 -4244
RPS15 -4222
DIMT1 -4135
RPL7A -4057
RPL27A -4009
WDR18 -4005
RPS21 -4002
RPL29 -3938
RPS25 -3919
MTREX -3902
RPL13A -3862
RPL35A -3799
FAU -3776
RPL38 -3763
RPL10A -3747
RPL31 -3745
RPS5 -3743
C1D -3679
RPLP1 -3664
RPL12 -3595
RPL18A -3559
RPS6 -3486
RPL5 -3471
RPS27A -3448
RPS17 -3388
RPL23 -3320
EXOSC3 -3289
UTP18 -3266
RPL15 -3201
LAS1L -2979
RPS24 -2970
RPL34 -2834
EXOSC8 -2781
RPL19 -2757
RPL7 -2750
RPL37A -2738
ISG20L2 -2719
RPS3 -2711
RPL26L1 -2708
RPL23A -2704
RPL22 -2693
RPS15A -2633
RPS29 -2569
RPL6 -2567
RPL10 -2555
NOL11 -2537
RBM28 -2502
RIOK2 -2491
RPL27 -2349
NCL -2347
RRP1 -2302
RPS12 -2296
RPL21 -2283
RPL4 -2274
BMS1 -2254
SENP3 -2221
EBNA1BP2 -2139
EXOSC5 -2136
UTP3 -2123
LTV1 -2108
PDCD11 -2104
NOL12 -2047
NOP56 -2046
EXOSC4 -2025
RPP38 -1963
RPS10 -1954
RPL17 -1931
RPL41 -1724
UTP11 -1630
DKC1 -1526
RPS3A -1430
EXOSC7 -1306
GAR1 -1186
UTP4 -1134
RPL26 -1088
RPL14 -1062
RPS19 -981
RPP40 -945
TEX10 -885
RPS7 -815
SNU13 -789
WDR12 -446
RPS4Y1 -397
RPL36A -308
HEATR1 -306
THUMPD1 -225
XRN2 -191
EMG1 117
RPL39L 144
RPS16 184
NIP7 251
RRP7A 253
MPHOSPH10 364
DIS3 759
UTP20 868
NOC4L 947
RPL36AL 1042
EXOSC1 1065
RPS13 1175
RPP14 1220
UTP25 1520
PNO1 1604
RPS9 1610
RPP30 1650
FCF1 1943
RPLP0 1980
NOP14 2357
RIOK3 2668
RPP21 2679
TSR1 2680
KRR1 2808
RPS2 2979
MPHOSPH6 2983
NOP58 3290
RIOK1 3533
DCAF13 3797
DDX52 3821
DDX21 4061
UTP6 4265
DDX47 4724
NOP10 4819
RPL9 6398
CSNK1E 6429
ERI1 6681
RPL22L1 6714
GNL3 6734
RPS27L 7491
EXOSC9 7805
UTP15 7916
RPSA 8258
WDR75 8418


RHO GTPase Effectors

RHO GTPase Effectors
916
set RHO GTPase Effectors
setSize 243
pANOVA 3.95e-08
s.dist 0.205
p.adjustANOVA 1.46e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9180
S100A8 9123
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
DIAPH3 8870
H2AC6 8794
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
PRKCB 8675
KNTC1 8660
BUB1 8578
PRC1 8571
MAD2L1 8490
IQGAP3 8486
KIF5A 8383
RAC2 8334

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9180
S100A8 9123
ZWINT 9112
SPDL1 9028
NDC80 8933
NUF2 8902
DIAPH3 8870
H2AC6 8794
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
PRKCB 8675
KNTC1 8660
BUB1 8578
PRC1 8571
MAD2L1 8490
IQGAP3 8486
KIF5A 8383
RAC2 8334
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
H2BC5 8216
ABI1 8160
CENPO 8144
SPC24 8118
LIMK2 8053
CENPP 7938
H3-3A 7937
CENPA 7870
CENPN 7635
KDM4C 7591
KIF14 7587
LIMK1 7568
FMNL2 7383
ITGB1 7377
ACTR3 7347
ZWILCH 7311
CENPM 7233
NUP107 7149
YWHAQ 7139
CALM1 7072
CENPK 7060
NCF2 7035
DAAM1 7013
ITGB3BP 6916
CENPC 6905
CDCA8 6887
CTNNB1 6885
CENPE 6840
KIF5B 6745
H2AZ1 6727
ACTR2 6719
SRGAP2 6649
CENPI 6571
WIPF1 6477
H2AC18 6414
CYFIP2 6304
KNL1 6300
YWHAG 6286
NCKAP1 6268
PKN2 6111
ABI2 6106
CDC20 6096
MYL6 5941
ROCK1 5832
CTTN 5675
XPO1 5625
H2AZ2 5520
CENPQ 5514
BUB3 5458
PPP1CB 5311
ARPC2 5282
ERCC6L 5156
MAPRE1 5048
FMNL3 5046
DVL3 4992
NDE1 4928
PDPK1 4887
DSN1 4816
MAPK1 4733
NUP37 4625
ROCK2 4560
KTN1 4536
KIF2A 4530
KLC2 4497
TAOK1 4480
SEH1L 4433
PFN2 4401
PPP2R5A 4400
AHCTF1 4308
RHOQ 4285
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
ARPC3 4051
PPP2CA 4034
ZW10 4008
DYNC1LI2 4005
CENPH 3875
NCOA2 3804
H2BU1 3777
SKA1 3729
PRKCA 3672
SRF 3647
CLASP2 3637
PPP2R5C 3488
WASL 3461
CKAP5 3402
PLK1 3164
YWHAZ 3108
SGO2 3092
PRKCZ 3055
MYL12B 3029
ARPC5 2999
PAK1 2998
RHOD 2941
PPP2CB 2822
CLIP1 2815
NUP160 2749
CYFIP1 2740
DYNC1LI1 2713
SPC25 2593
PPP2R5B 2592
IQGAP1 2530
PIN1 2523
CFL1 2483
NUP85 2385
PPP1R12A 2230
CIT 2190
NDEL1 2105
CENPL 1908
PAK2 1875
PKN3 1873
NSL1 1865
KLC1 1849
CLASP1 1830
SKA2 1817
CTNNA1 1815
BTK 1744
SCAI 1620
DYNLL1 1561
YWHAE 1494
DLG4 1474
H2BC4 1261
DIAPH1 1251
CENPT 1162
RANBP2 1105
MIS12 1040
B9D2 872
H2AJ 847
GOPC 492
ACTG1 355
FLNA 287
PFN1 246
EVL 114
KLC4 -111
TAX1BP3 -176
CDC42 -229
SEC13 -240
LIN7B -319
KDM1A -580
ARPC1B -597
PMF1 -611
MAPK14 -684
RHOC -685
PIK3C3 -793
YWHAB -909
DYNC1H1 -1028
CDKN1B -1066
RHPN2 -1104
PPP1CC -1467
DYNC1I1 -1561
BRK1 -1584
NUP43 -1806
RHOA -1834
MAD1L1 -1976
PPP2R5E -2059
NCK1 -2177
NCKIPSD -2186
DVL1 -2189
WIPF2 -2197
RTKN -2241
PRKCD -2334
MYH14 -2755
ACTB -3297
RCC2 -3305
ARPC4 -3439
NUP133 -3621
INCENP -4011
SFN -4148
MYLK -4236
CYBA -4304
DVL2 -4322
PPP2R5D -4551
RHOB -4591
PTK2 -4681
YWHAH -4728
PPP1R12B -4730
GRB2 -4777
NCKAP1L -4809
WASF3 -4974
MYH9 -5033
NCF4 -5177
RAC1 -5383
RPS27 -5510
RANGAP1 -5521
ABL1 -5571
BAIAP2 -5727
NUDC -5900
MYH10 -5926
FMNL1 -6008
WASF2 -6027
SRC -6078
PIK3R4 -6113
MAPK11 -6182
H2BC12 -6254
NUP98 -6316
WAS -6425
RHOG -6703
DYNLL2 -6837
PKN1 -6903
MAPK3 -6930
WIPF3 -6964
PPP2R1A -7410
WASF1 -7416
AR -7550
NF2 -7562
MYH11 -7731
IQGAP2 -7736
MEN1 -7898
DIAPH2 -7909
PPP1R14A -7952
CYBB -7976
ARPC1A -7978
NCF1 -8038
MYL9 -8062
NOXA1 -8368
MRTFA -8646
RHPN1 -9065
PAK3 -9092


Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
652
set Major pathway of rRNA processing in the nucleolus and cytosol
setSize 180
pANOVA 1.03e-07
s.dist -0.23
p.adjustANOVA 3.73e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
UTP14C -9087
NOL6 -8942
NOL9 -8705
RPS26 -8665
EXOSC6 -8570
TBL3 -8403
DHX37 -8228
WDR46 -7843
RPS4X -7595
BYSL -7533
IMP3 -7513
PES1 -7460
RCL1 -7407
NOB1 -7220
EXOSC10 -7045
PWP2 -6950
RPS14 -6788
PELP1 -6728
RPL28 -6570
CSNK1D -6568

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UTP14C -9087
NOL6 -8942
NOL9 -8705
RPS26 -8665
EXOSC6 -8570
TBL3 -8403
DHX37 -8228
WDR46 -7843
RPS4X -7595
BYSL -7533
IMP3 -7513
PES1 -7460
RCL1 -7407
NOB1 -7220
EXOSC10 -7045
PWP2 -6950
RPS14 -6788
PELP1 -6728
RPL28 -6570
CSNK1D -6568
FTSJ3 -6378
RPL13 -6363
RPL8 -6361
FBL -6190
RPL36 -6030
UTP14A -5991
RPL39 -5932
RRP9 -5902
RPLP2 -5890
DDX49 -5888
RPP25 -5836
RRP36 -5731
IMP4 -5590
RPS18 -5579
EXOSC2 -5539
RPL11 -5519
RPS27 -5510
RPL32 -5488
RPS28 -5453
BOP1 -5425
WDR43 -5402
RPL24 -5320
RPS8 -5159
RPL35 -5082
RPS23 -4831
RPL37 -4759
RPS20 -4706
RPL18 -4688
RPL30 -4524
RPL3 -4463
UBA52 -4448
WDR3 -4396
RPL3L -4369
WDR36 -4312
RPS11 -4244
RPS15 -4222
RPL7A -4057
RPL27A -4009
WDR18 -4005
RPS21 -4002
RPL29 -3938
RPS25 -3919
MTREX -3902
RPL13A -3862
RPL35A -3799
FAU -3776
RPL38 -3763
RPL10A -3747
RPL31 -3745
RPS5 -3743
C1D -3679
RPLP1 -3664
RPL12 -3595
RPL18A -3559
RPS6 -3486
RPL5 -3471
RPS27A -3448
RPS17 -3388
RPL23 -3320
EXOSC3 -3289
UTP18 -3266
RPL15 -3201
LAS1L -2979
RPS24 -2970
RPL34 -2834
EXOSC8 -2781
RPL19 -2757
RPL7 -2750
RPL37A -2738
ISG20L2 -2719
RPS3 -2711
RPL26L1 -2708
RPL23A -2704
RPL22 -2693
RPS15A -2633
RPS29 -2569
RPL6 -2567
RPL10 -2555
NOL11 -2537
RBM28 -2502
RIOK2 -2491
RPL27 -2349
NCL -2347
RRP1 -2302
RPS12 -2296
RPL21 -2283
RPL4 -2274
BMS1 -2254
SENP3 -2221
EBNA1BP2 -2139
EXOSC5 -2136
UTP3 -2123
LTV1 -2108
PDCD11 -2104
NOL12 -2047
NOP56 -2046
EXOSC4 -2025
RPP38 -1963
RPS10 -1954
RPL17 -1931
RPL41 -1724
UTP11 -1630
RPS3A -1430
EXOSC7 -1306
UTP4 -1134
RPL26 -1088
RPL14 -1062
RPS19 -981
RPP40 -945
TEX10 -885
RPS7 -815
SNU13 -789
WDR12 -446
RPS4Y1 -397
RPL36A -308
HEATR1 -306
XRN2 -191
EMG1 117
RPL39L 144
RPS16 184
NIP7 251
RRP7A 253
MPHOSPH10 364
DIS3 759
UTP20 868
NOC4L 947
RPL36AL 1042
EXOSC1 1065
RPS13 1175
RPP14 1220
UTP25 1520
PNO1 1604
RPS9 1610
RPP30 1650
FCF1 1943
RPLP0 1980
NOP14 2357
RIOK3 2668
RPP21 2679
TSR1 2680
KRR1 2808
RPS2 2979
MPHOSPH6 2983
NOP58 3290
RIOK1 3533
DCAF13 3797
DDX52 3821
DDX21 4061
UTP6 4265
DDX47 4724
RPL9 6398
CSNK1E 6429
ERI1 6681
RPL22L1 6714
GNL3 6734
RPS27L 7491
EXOSC9 7805
UTP15 7916
RPSA 8258
WDR75 8418


G2/M Checkpoints

G2/M Checkpoints
440
set G2/M Checkpoints
setSize 133
pANOVA 3.97e-07
s.dist 0.255
p.adjustANOVA 1.4e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC45 9100
BRIP1 8756
ORC6 8732
H2BC21 8730
CDC6 8647
MCM10 8617
GTSE1 8601
MCM8 8519
CDK2 8505
CDK1 8482
PKMYT1 8461
CCNB1 8255
ORC2 8252
CHEK1 8237
H2BC5 8216
CLSPN 8207
CCNB2 8202
NSD2 8036
ATR 7993
MCM4 7784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC45 9100
BRIP1 8756
ORC6 8732
H2BC21 8730
CDC6 8647
MCM10 8617
GTSE1 8601
MCM8 8519
CDK2 8505
CDK1 8482
PKMYT1 8461
CCNB1 8255
ORC2 8252
CHEK1 8237
H2BC5 8216
CLSPN 8207
CCNB2 8202
NSD2 8036
ATR 7993
MCM4 7784
MCM2 7760
RAD9B 7736
NBN 7660
PSMA5 7283
TP53BP1 7241
MRE11 7211
CDC7 7164
YWHAQ 7139
RNF168 7128
DBF4 6792
HUS1 6558
PSMD10 6444
RFC4 6443
YWHAG 6286
RBBP8 6197
BARD1 6095
CDC25A 5871
WRN 5756
BRCA1 5710
HERC2 5616
PSMD14 5533
PSMA2 5379
TOPBP1 5197
RAD9A 4991
PSMD1 4898
UBE2N 4863
PSMD12 4794
PSMC6 4558
PSME4 4470
PSMC1 4201
PSMB4 3958
PSMB7 3904
PSMD11 3785
H2BU1 3777
PSME2 3582
RNF8 3536
PSMD7 3466
SEM1 3400
UBE2V2 3351
BLM 3335
PSMA4 3210
MCM5 3190
WEE1 3185
DNA2 3175
PSMD9 3119
YWHAZ 3108
PSMA7 2958
PSMB6 2743
RFC2 2464
PSMA6 2325
SUMO1 2289
UIMC1 2202
PSMB1 2193
ATM 1949
PSMA1 1881
RMI1 1762
PSMB5 1588
PIAS4 1497
YWHAE 1494
BRCC3 1272
RMI2 1266
UBB 1263
H2BC4 1261
PSME3 1142
MCM7 1095
PSMB2 809
PSMB3 777
MCM3 755
RAD17 494
PSMC2 361
MCM6 313
ORC3 83
RFC5 70
PSMA3 -465
PSMD2 -498
UBC -514
PSMD8 -867
YWHAB -909
PSMD5 -915
RPA3 -1004
ORC4 -1247
PSMD6 -1289
ORC1 -1359
RAD1 -1451
PSMD13 -1463
PSMC5 -2016
MDC1 -2140
PSMC3 -2697
BABAM1 -2725
TOP3A -3014
RFC3 -3056
PSMD4 -3294
RPS27A -3448
PSMC4 -3885
SFN -4148
PSMB8 -4218
UBA52 -4448
ORC5 -4482
PSME1 -4498
RPA1 -4619
YWHAH -4728
PSMD3 -4749
RHNO1 -5228
PSMB10 -5760
ATRIP -6125
H2BC12 -6254
PSMB9 -6888
RPA2 -7206
RAD50 -7432
PSMF1 -7531
KAT5 -7538
CHEK2 -8067
TP53 -8197


Mitotic G2-G2/M phases

Mitotic G2-G2/M phases
700
set Mitotic G2-G2/M phases
setSize 180
pANOVA 4.58e-07
s.dist 0.218
p.adjustANOVA 1.57e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYBL2 9120
PHLDA1 9055
CDKN1A 8844
GTSE1 8601
CCNA2 8584
CDK2 8505
CEP152 8487
CDK1 8482
PKMYT1 8461
MZT1 8424
E2F1 8341
CENPF 8317
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
HMMR 8073
FOXM1 7954
FBXL7 7714
TPX2 7689
LIN9 7621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYBL2 9120
PHLDA1 9055
CDKN1A 8844
GTSE1 8601
CCNA2 8584
CDK2 8505
CEP152 8487
CDK1 8482
PKMYT1 8461
MZT1 8424
E2F1 8341
CENPF 8317
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
HMMR 8073
FOXM1 7954
FBXL7 7714
TPX2 7689
LIN9 7621
MNAT1 7615
NINL 7569
TUBGCP4 7410
PSMA5 7283
TUBA1A 6985
SFI1 6966
TUBGCP3 6928
NEDD1 6927
CCP110 6913
TUBGCP5 6908
CEP70 6790
PSMD10 6444
CNTRL 6435
CSNK1E 6429
CEP63 6336
YWHAG 6286
AKAP9 6242
E2F3 6127
PCM1 5901
PCNT 5894
CDC25A 5871
XPO1 5625
PSMD14 5533
CEP250 5449
FBXW11 5410
CEP135 5383
PSMA2 5379
PPP1CB 5311
ALMS1 5123
MAPRE1 5048
NDE1 4928
PSMD1 4898
OPTN 4873
PSMD12 4794
CEP41 4601
PSMC6 4558
CEP290 4523
PSME4 4470
PLK4 4324
DYNC1I2 4284
PAFAH1B1 4255
CEP43 4210
PSMC1 4201
PPP2CA 4034
PSMB4 3958
PSMB7 3904
NME7 3870
PSMD11 3785
PSME2 3582
CDK7 3563
PPP2R2A 3477
PSMD7 3466
BORA 3425
CKAP5 3402
SEM1 3400
RBX1 3283
PSMA4 3210
AURKA 3195
WEE1 3185
PLK1 3164
PSMD9 3119
NEK2 3008
PSMA7 2958
CCNH 2900
PPP2CB 2822
PSMB6 2743
CEP164 2634
SKP1 2463
PSMA6 2325
PPP1R12A 2230
PSMB1 2193
PSMA1 1881
CLASP1 1830
OFD1 1761
HAUS5 1667
PSMB5 1588
DYNLL1 1561
HAUS6 1519
CEP78 1504
YWHAE 1494
LIN54 1433
UBB 1263
PSME3 1142
CEP192 984
CDK5RAP2 958
HSP90AA1 820
PSMB2 809
PSMB3 777
TUBG2 726
CEP76 490
CEP57 474
PSMC2 361
HSP90AB1 348
CETN2 224
CEP72 -71
RBBP4 -106
FKBPL -141
TUBB4B -239
MZT2A -357
EP300 -408
PPME1 -432
PSMA3 -465
PSMD2 -498
UBC -514
CDC25B -519
TUBGCP6 -558
LIN37 -764
CENPJ -806
HAUS3 -853
PSMD8 -867
PSMD5 -915
DYNC1H1 -1028
TUBGCP2 -1103
RAB8A -1131
PPP2R3B -1160
ACTR1A -1197
PSMD6 -1289
DCTN3 -1385
MZT2B -1440
PSMD13 -1463
FBXL18 -1685
SDCCAG8 -1729
HAUS7 -1810
TUBA4A -1872
PSMC5 -2016
TUBB -2087
SSNA1 -2131
LIN52 -2405
DCTN2 -2463
CEP131 -2518
HAUS1 -2630
PSMC3 -2697
LCMT1 -2912
HAUS2 -3059
ODF2 -3131
BTRC -3151
HAUS4 -3269
PSMD4 -3294
RPS27A -3448
PSMC4 -3885
PSMB8 -4218
CUL1 -4413
UBA52 -4448
PSME1 -4498
PPP1R12B -4730
PSMD3 -4749
AJUBA -4881
TUBG1 -4887
HAUS8 -5594
PSMB10 -5760
DCTN1 -6110
CSNK1D -6568
CDK11B -6884
PSMB9 -6888
PPP2R1A -7410
PSMF1 -7531
CDK11A -7537
PRKACA -7564
TP53 -8197
PRKAR2B -8427


Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Signaling by Rho GTPases, Miro GTPases and RHOBTB3
1209
set Signaling by Rho GTPases, Miro GTPases and RHOBTB3
setSize 621
pANOVA 6.41e-07
s.dist 0.117
p.adjustANOVA 2.15e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9180
RND1 9135
S100A8 9123
ZWINT 9112
SPDL1 9028
SPATA13 8981
CKB 8953
NDC80 8933
GJA1 8907
NUF2 8902
DIAPH3 8870
LMNB1 8850
TPM4 8847
H2AC6 8794
RACGAP1 8791
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
MPP7 8704

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9180
RND1 9135
S100A8 9123
ZWINT 9112
SPDL1 9028
SPATA13 8981
CKB 8953
NDC80 8933
GJA1 8907
NUF2 8902
DIAPH3 8870
LMNB1 8850
TPM4 8847
H2AC6 8794
RACGAP1 8791
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
MPP7 8704
PCDH7 8701
RND3 8683
PRKCB 8675
KNTC1 8660
RHOBTB1 8642
ZAP70 8612
BUB1 8578
PRC1 8571
ECT2 8541
RASAL2 8514
MAD2L1 8490
IQGAP3 8486
ANLN 8400
TFRC 8396
KIF5A 8383
FGD3 8375
GNA13 8363
RAC2 8334
ARHGAP11B 8326
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
ARHGAP9 8263
H2BC5 8216
ABI1 8160
SH3PXD2A 8158
CENPO 8144
SRGAP3 8120
SPC24 8118
TAGAP 8111
LIMK2 8053
TRIO 7976
MSI2 7947
CENPP 7938
H3-3A 7937
ARHGEF16 7894
CENPA 7870
DSG2 7866
ACBD5 7859
ACTN1 7788
DOCK10 7747
ABL2 7652
CENPN 7635
MYO6 7623
MYO19 7610
WDR91 7606
KDM4C 7591
KIF14 7587
CCDC88A 7579
LIMK1 7568
PLXNB1 7487
UHRF1BP1L 7456
FMNL2 7383
ITGB1 7377
ACTR3 7347
ZWILCH 7311
VAV3 7268
WDR11 7262
DOCK7 7238
CENPM 7233
KIDINS220 7206
NUP107 7149
YWHAQ 7139
STK38 7121
ANKLE2 7114
STBD1 7106
CALM1 7072
CENPK 7060
DOCK5 7037
NCF2 7035
DAAM1 7013
ITGB3BP 6916
CCP110 6913
CENPC 6905
KCTD3 6894
CDCA8 6887
RHOBTB3 6886
CTNNB1 6885
RAP1GDS1 6858
CENPE 6840
UACA 6791
KIF5B 6745
H2AZ1 6727
ACTR2 6719
ARHGEF19 6705
SRGAP2 6649
ARHGAP11A 6615
BAIAP2L1 6580
CENPI 6571
DST 6518
ARHGAP28 6515
WIPF1 6477
PIK3CA 6452
H2AC18 6414
ARHGAP44 6354
CYFIP2 6304
KNL1 6300
YWHAG 6286
ARHGEF9 6278
NCKAP1 6268
RHOF 6259
AKAP13 6244
PICALM 6239
HSPE1 6164
ARHGEF39 6144
PKN2 6111
ABI2 6106
CDC20 6096
OCRL 5972
CAPZB 5943
MYL6 5941
WWP2 5940
SLC4A7 5922
DDX39B 5895
ROCK1 5832
MTR 5811
SHKBP1 5802
TMOD3 5780
ARMCX3 5766
ABCD3 5753
ARHGEF5 5698
DEF6 5689
CTTN 5675
TRA2B 5627
XPO1 5625
H2AZ2 5520
CENPQ 5514
TMEM87A 5497
BUB3 5458
SRGAP1 5444
VRK2 5417
FERMT2 5384
LEMD3 5367
STEAP3 5335
PPP1CB 5311
TRAK2 5307
ARPC2 5282
SCFD1 5278
DLG5 5242
BASP1 5236
SWAP70 5221
ABR 5198
CHN1 5180
ERCC6L 5156
RAB7A 5077
TIAM2 5070
MAPRE1 5048
FMNL3 5046
ACTC1 5029
KALRN 5015
DVL3 4992
CDC42BPA 4972
FAM91A1 4944
NDE1 4928
PDPK1 4887
CCNE1 4861
CEP97 4852
ARHGAP42 4849
DSN1 4816
PREX2 4805
ARHGAP25 4754
CCT2 4749
GMIP 4747
MAPK1 4733
NUP37 4625
NHS 4579
ROCK2 4560
GARRE1 4544
KTN1 4536
KIF2A 4530
TAOK3 4504
KLC2 4497
TAOK1 4480
SLK 4466
DOCK9 4437
SEH1L 4433
ARHGAP22 4427
PFN2 4401
PPP2R5A 4400
RAC3 4334
LRRC1 4327
AHCTF1 4308
RHOQ 4285
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
MOSPD2 4154
MACO1 4127
NDUFA5 4124
STAM 4117
SNAP23 4072
ARPC3 4051
GOLGA8R 4045
PPP2CA 4034
ARHGAP32 4017
ZW10 4008
DYNC1LI2 4005
DLC1 3998
CENPH 3875
RHOT1 3874
ARHGEF12 3816
NCOA2 3804
H2BU1 3777
COPS2 3744
SKA1 3729
DOCK4 3701
STK10 3680
PRKCA 3672
SRF 3647
CLASP2 3637
FNBP1L 3562
PARD6B 3509
PPP2R5C 3488
WASL 3461
CKAP5 3402
TNFAIP1 3327
SH3RF1 3263
GIT2 3219
PLK1 3164
YWHAZ 3108
SGO2 3092
MFN1 3087
PRKCZ 3055
PLEKHG2 3052
MYL12B 3029
ARPC5 2999
PAK1 2998
SOWAHC 2944
RHOD 2941
ARHGAP12 2937
SLC1A5 2918
TPM3 2840
RHOJ 2833
PPP2CB 2822
CLIP1 2815
NUP160 2749
CYFIP1 2740
CUL3 2724
DYNC1LI1 2713
FRS2 2656
SPC25 2593
PPP2R5B 2592
IQGAP1 2530
PIN1 2523
ARHGEF6 2514
TJP2 2510
RALGAPA1 2491
CFL1 2483
LBR 2457
CDC42SE2 2422
NUP85 2385
SYDE2 2355
ARFGAP3 2348
PTK2B 2242
RASGRF2 2236
PPP1R12A 2230
CIT 2190
DSP 2130
NDEL1 2105
EPSTI1 2028
VANGL1 2026
ARHGEF3 2019
TRAK1 2014
RBMX 1981
TXNL1 1953
RALBP1 1911
CENPL 1908
FARP1 1889
PAK2 1875
PKN3 1873
NSL1 1865
KLC1 1849
CLASP1 1830
MTX1 1829
PLEKHG3 1826
SKA2 1817
CTNNA1 1815
ERBIN 1809
ARHGAP29 1777
BTK 1744
GOLGA3 1701
ARAP3 1679
SCAI 1620
DYNLL1 1561
CDC42EP3 1552
ARL13B 1551
YWHAE 1494
DLG4 1474
HNRNPC 1458
RND2 1363
DOCK1 1351
ELMO2 1306
H2BC4 1261
DIAPH1 1251
PLEKHG1 1202
EMC3 1193
CENPT 1162
ARHGEF10 1150
RANBP2 1105
ALS2 1050
MIS12 1040
FAM135A 945
CCT6A 894
B9D2 872
NGEF 855
H2AJ 847
HSP90AA1 820
LETM1 805
SOS2 803
LCK 766
ANKRD26 717
CPD 682
CDC37 673
DOCK11 671
ARHGAP10 613
JAG1 584
ARHGDIB 557
PLD1 545
DDRGK1 518
VHL 516
GOPC 492
EPHA2 449
RBBP6 394
OSBPL11 393
TUBA1B 379
ACTG1 355
HSP90AB1 348
C1QBP 314
FLNA 287
PLXNA1 269
ARHGAP21 261
PFN1 246
PEAK1 214
GFOD1 203
EVL 114
ARHGAP35 94
MCF2L 92
MTMR1 43
NDUFS3 -33
KLC4 -111
AMIGO2 -122
SAMM50 -147
TAX1BP3 -176
CDC42 -229
SEC13 -240
IL32 -249
EMD -259
LIN7B -319
TWF1 -321
NISCH -338
TOR1AIP1 -370
USP9X -388
PLIN3 -401
CCT7 -407
BCAP31 -409
FAM13A -467
KDM1A -580
ARPC1B -597
PMF1 -611
RHOH -621
MAPK14 -684
RHOC -685
RAB9A -687
FGD1 -701
DOCK8 -750
FLOT1 -754
DBT -755
ARHGAP30 -783
PIK3C3 -793
SOS1 -829
PLD2 -850
WHAMM -855
ARHGEF25 -881
YWHAB -909
PREX1 -941
STAM2 -991
ARHGAP24 -997
MYO9B -1009
DYNC1H1 -1028
CDKN1B -1066
VIM -1071
RHPN2 -1104
ARHGAP15 -1119
HTR7 -1166
FAF2 -1169
BAIAP2L2 -1191
ARHGAP19 -1239
ARHGEF40 -1242
RAPGEF1 -1286
STARD13 -1365
ATP6AP1 -1376
CPNE8 -1400
YKT6 -1408
STIP1 -1459
PPP1CC -1467
LMAN1 -1480
OBSCN -1483
PIK3R2 -1500
DYNC1I1 -1561
BRK1 -1584
ARHGEF28 -1642
COPS4 -1660
VCP -1676
PKP4 -1712
NUP43 -1806
RHOA -1834
RHOT2 -1903
MAD1L1 -1976
PPP2R5E -2059
ARHGAP5 -2073
SENP1 -2093
NCK1 -2177
NCKIPSD -2186
DVL1 -2189
WIPF2 -2197
ARHGEF7 -2232
RTKN -2241
CPSF7 -2272
DOCK6 -2276
PRKCD -2334
SEMA4F -2339
ARHGEF11 -2377
ARHGEF17 -2394
NSFL1C -2441
ARHGAP31 -2460
CLTC -2520
FARP2 -2538
ARAP1 -2551
ARHGAP1 -2597
RNF20 -2714
MFN2 -2734
MYH14 -2755
NCK2 -2759
ARHGAP39 -2967
MCAM -3029
ARHGEF15 -3046
SPEN -3218
VAMP3 -3248
ACTB -3297
RCC2 -3305
HMOX2 -3338
RHOBTB2 -3365
PTPN13 -3391
WDR6 -3419
GPS1 -3434
ARPC4 -3439
HGS -3555
TMPO -3596
ITSN2 -3617
NUP133 -3621
ARHGAP33 -3773
ARHGAP26 -3827
LRRC41 -3851
ARAP2 -3874
PGRMC2 -3973
CKAP4 -3974
CAV1 -3989
FNBP1 -4010
INCENP -4011
DEPDC1B -4107
SFN -4148
MYLK -4236
CYBA -4304
CCDC115 -4313
DVL2 -4322
ADD3 -4364
ITSN1 -4390
ZNF512B -4418
HINT2 -4497
PPP2R5D -4551
ANKFY1 -4557
ARHGAP27 -4558
EFHD2 -4570
ARHGEF1 -4574
UBXN11 -4577
RHOB -4591
PTK2 -4681
AAAS -4689
JUP -4695
YWHAH -4728
PPP1R12B -4730
STOM -4738
GRB2 -4777
NCKAP1L -4809
TEX2 -4878
SHMT2 -4911
PLEKHG6 -4964
WASF3 -4974
LAMTOR1 -5031
MYH9 -5033
KCTD13 -5036
RRAS2 -5057
TMEM59 -5099
SRRM1 -5119
NCF4 -5177
VAPB -5213
CDC42BPB -5274
MYO9A -5324
RAC1 -5383
STMN2 -5392
ARHGAP8 -5404
PAK4 -5405
ARHGAP18 -5411
RPS27 -5510
RANGAP1 -5521
ABL1 -5571
PLEKHG4 -5624
VAV2 -5663
TIAM1 -5718
BAIAP2 -5727
DOCK3 -5796
STX5 -5873
CDC42EP5 -5882
NUDC -5900
MYH10 -5926
PHIP -5943
PARD6A -5985
FMNL1 -6008
WASF2 -6027
ARHGAP4 -6032
SRC -6078
PIK3R4 -6113
ESYT1 -6116
OPHN1 -6123
ARHGAP17 -6127
MAPK11 -6182
PLXND1 -6204
SPTAN1 -6243
H2BC12 -6254
WDR81 -6270
NUP98 -6316
WAS -6425
FAM13B -6477
SYDE1 -6618
VANGL2 -6640
ARHGEF2 -6645
RHOG -6703
FILIP1 -6732
SCRIB -6783
FGD5 -6826
DYNLL2 -6837
DOCK2 -6866
PKN1 -6903
MAPK3 -6930
DBN1 -6947
WIPF3 -6964
ARHGDIA -7018
FRS3 -7062
GIT1 -7068
ARFGAP2 -7079
TRIP10 -7249
ARHGEF18 -7376
PPP2R1A -7410
WASF1 -7416
PLEKHG5 -7526
AR -7550
SPTBN1 -7560
NF2 -7562
ARHGEF26 -7598
ARHGEF4 -7621
MYH11 -7731
IQGAP2 -7736
NET1 -7764
ALDH3A2 -7866
MEN1 -7898
CDC42EP1 -7907
DIAPH2 -7909
FGD4 -7930
PPP1R14A -7952
CYBB -7976
ARPC1A -7978
STARD8 -8001
PDE5A -8030
NCF1 -8038
ARHGAP23 -8056
MYL9 -8062
CDC42EP2 -8081
CSK -8169
FLOT2 -8318
ARHGAP6 -8344
NOXA1 -8368
GRB7 -8374
ARHGEF10L -8385
VAV1 -8460
SH3BP1 -8471
MAP3K11 -8512
MRTFA -8646
RAB9B -8661
PIK3R3 -8805
CDC42EP4 -8826
BCR -8902
FGD2 -8940
RHOU -8978
DNMBP -9019
CHN2 -9057
RHPN1 -9065
ARHGAP20 -9067
PAK3 -9092
AKAP12 -9144
PIK3R1 -9386


DNA Replication

DNA Replication
254
set DNA Replication
setSize 138
pANOVA 8.56e-07
s.dist 0.243
p.adjustANOVA 2.81e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDC45 9100
GMNN 8906
H2AC6 8794
ORC6 8732
H2BC21 8730
E2F2 8720
UBE2S 8700
CDC6 8647
MCM10 8617
CCNA2 8584
MCM8 8519
CDK2 8505
E2F1 8341
ORC2 8252
H2BC5 8216
GINS2 8102
PCNA 8082
H3-3A 7937
UBE2C 7882
MCM4 7784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDC45 9100
GMNN 8906
H2AC6 8794
ORC6 8732
H2BC21 8730
E2F2 8720
UBE2S 8700
CDC6 8647
MCM10 8617
CCNA2 8584
MCM8 8519
CDK2 8505
E2F1 8341
ORC2 8252
H2BC5 8216
GINS2 8102
PCNA 8082
H3-3A 7937
UBE2C 7882
MCM4 7784
MCM2 7760
LIG1 7633
CCNE2 7632
GINS4 7604
PSMA5 7283
UBE2D1 7209
CDC7 7164
DBF4 6792
H2AZ1 6727
PSMD10 6444
RFC4 6443
H2AC18 6414
CDT1 6308
E2F3 6127
ANAPC5 6110
KPNA6 6002
PSMD14 5533
H2AZ2 5520
ANAPC10 5493
PSMA2 5379
KPNB1 5308
UBE2E1 5188
ANAPC4 5178
PSMD1 4898
CCNE1 4861
ANAPC15 4796
PSMD12 4794
PRIM2 4619
PSMC6 4558
PSME4 4470
PSMC1 4201
CDC16 4138
PSMB4 3958
PSMB7 3904
POLE2 3809
PSMD11 3785
H2BU1 3777
PSME2 3582
PSMD7 3466
SEM1 3400
RBX1 3283
PSMA4 3210
MCM5 3190
DNA2 3175
PSMD9 3119
PSMA7 2958
PSMB6 2743
RFC2 2464
SKP1 2463
PSMA6 2325
PSMB1 2193
POLA1 2171
POLD3 1954
PSMA1 1881
PSMB5 1588
FEN1 1436
SKP2 1310
UBB 1263
H2BC4 1261
ANAPC11 1164
PSME3 1142
MCM7 1095
H2AJ 847
PSMB2 809
PSMB3 777
MCM3 755
POLD1 667
KPNA1 658
PSMC2 361
MCM6 313
ORC3 83
RFC5 70
ANAPC7 -246
GINS1 -255
FZR1 -437
PSMA3 -465
PSMD2 -498
UBC -514
PSMD8 -867
PSMD5 -915
RPA3 -1004
ANAPC1 -1157
ORC4 -1247
PSMD6 -1289
PRIM1 -1353
ORC1 -1359
PSMD13 -1463
ANAPC2 -1671
CDC27 -1716
RFC1 -1874
CDC26 -1879
POLE -1893
PSMC5 -2016
PSMC3 -2697
RFC3 -3056
ANAPC16 -3165
PSMD4 -3294
RPS27A -3448
PSMC4 -3885
CDC23 -4123
PSMB8 -4218
CUL1 -4413
UBA52 -4448
ORC5 -4482
PSME1 -4498
RPA1 -4619
PSMD3 -4749
POLE3 -5073
POLE4 -5525
PSMB10 -5760
POLD2 -5903
GINS3 -6131
H2BC12 -6254
POLA2 -6749
PSMB9 -6888
RPA2 -7206
PSMF1 -7531
POLD4 -7884


FCERI mediated Ca+2 mobilization

FCERI mediated Ca+2 mobilization
377
set FCERI mediated Ca+2 mobilization
setSize 57
pANOVA 1.05e-06
s.dist -0.374
p.adjustANOVA 3.36e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGKV3-20 -9063
IGLV2-8 -9051
IGHV2-5 -8925
IGLV1-51 -8906
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
IGKV3-15 -7850
IGLV1-44 -7694
SYK -7360
IGHV3-33 -6656
VAV2 -5663
GRB2 -4777
PLCG2 -4620
LCP2 -4226
IGKV1-33 -2600
SOS1 -829
PPP3CB -15
ITPR3 513
PLCG1 819
NFATC1 972
GRAP2 1296
TXK 1396
BTK 1744
AHCYL1 2038
NFATC2 2136
NFATC3 2177
LYN 2420
TEC 3799
PPP3R1 4689
PPP3CA 4885
SHC1 5065
LAT 6051
ITK 6460
CALM1 7072
VAV3 7268
ITPR2 8466
ITPR1 8491


G2/M Transition

G2/M Transition
442
set G2/M Transition
setSize 178
pANOVA 1.15e-06
s.dist 0.211
p.adjustANOVA 3.59e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYBL2 9120
PHLDA1 9055
CDKN1A 8844
GTSE1 8601
CCNA2 8584
CDK2 8505
CEP152 8487
CDK1 8482
PKMYT1 8461
MZT1 8424
CENPF 8317
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
HMMR 8073
FOXM1 7954
FBXL7 7714
TPX2 7689
LIN9 7621
MNAT1 7615

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYBL2 9120
PHLDA1 9055
CDKN1A 8844
GTSE1 8601
CCNA2 8584
CDK2 8505
CEP152 8487
CDK1 8482
PKMYT1 8461
MZT1 8424
CENPF 8317
PPP2R1B 8292
CCNB1 8255
CCNB2 8202
HMMR 8073
FOXM1 7954
FBXL7 7714
TPX2 7689
LIN9 7621
MNAT1 7615
NINL 7569
TUBGCP4 7410
PSMA5 7283
TUBA1A 6985
SFI1 6966
TUBGCP3 6928
NEDD1 6927
CCP110 6913
TUBGCP5 6908
CEP70 6790
PSMD10 6444
CNTRL 6435
CSNK1E 6429
CEP63 6336
YWHAG 6286
AKAP9 6242
PCM1 5901
PCNT 5894
CDC25A 5871
XPO1 5625
PSMD14 5533
CEP250 5449
FBXW11 5410
CEP135 5383
PSMA2 5379
PPP1CB 5311
ALMS1 5123
MAPRE1 5048
NDE1 4928
PSMD1 4898
OPTN 4873
PSMD12 4794
CEP41 4601
PSMC6 4558
CEP290 4523
PSME4 4470
PLK4 4324
DYNC1I2 4284
PAFAH1B1 4255
CEP43 4210
PSMC1 4201
PPP2CA 4034
PSMB4 3958
PSMB7 3904
NME7 3870
PSMD11 3785
PSME2 3582
CDK7 3563
PPP2R2A 3477
PSMD7 3466
BORA 3425
CKAP5 3402
SEM1 3400
RBX1 3283
PSMA4 3210
AURKA 3195
WEE1 3185
PLK1 3164
PSMD9 3119
NEK2 3008
PSMA7 2958
CCNH 2900
PPP2CB 2822
PSMB6 2743
CEP164 2634
SKP1 2463
PSMA6 2325
PPP1R12A 2230
PSMB1 2193
PSMA1 1881
CLASP1 1830
OFD1 1761
HAUS5 1667
PSMB5 1588
DYNLL1 1561
HAUS6 1519
CEP78 1504
YWHAE 1494
LIN54 1433
UBB 1263
PSME3 1142
CEP192 984
CDK5RAP2 958
HSP90AA1 820
PSMB2 809
PSMB3 777
TUBG2 726
CEP76 490
CEP57 474
PSMC2 361
HSP90AB1 348
CETN2 224
CEP72 -71
RBBP4 -106
FKBPL -141
TUBB4B -239
MZT2A -357
EP300 -408
PPME1 -432
PSMA3 -465
PSMD2 -498
UBC -514
CDC25B -519
TUBGCP6 -558
LIN37 -764
CENPJ -806
HAUS3 -853
PSMD8 -867
PSMD5 -915
DYNC1H1 -1028
TUBGCP2 -1103
RAB8A -1131
PPP2R3B -1160
ACTR1A -1197
PSMD6 -1289
DCTN3 -1385
MZT2B -1440
PSMD13 -1463
FBXL18 -1685
SDCCAG8 -1729
HAUS7 -1810
TUBA4A -1872
PSMC5 -2016
TUBB -2087
SSNA1 -2131
LIN52 -2405
DCTN2 -2463
CEP131 -2518
HAUS1 -2630
PSMC3 -2697
LCMT1 -2912
HAUS2 -3059
ODF2 -3131
BTRC -3151
HAUS4 -3269
PSMD4 -3294
RPS27A -3448
PSMC4 -3885
PSMB8 -4218
CUL1 -4413
UBA52 -4448
PSME1 -4498
PPP1R12B -4730
PSMD3 -4749
AJUBA -4881
TUBG1 -4887
HAUS8 -5594
PSMB10 -5760
DCTN1 -6110
CSNK1D -6568
CDK11B -6884
PSMB9 -6888
PPP2R1A -7410
PSMF1 -7531
CDK11A -7537
PRKACA -7564
TP53 -8197
PRKAR2B -8427


Signaling by Rho GTPases

Signaling by Rho GTPases
1208
set Signaling by Rho GTPases
setSize 605
pANOVA 1.19e-06
s.dist 0.116
p.adjustANOVA 3.65e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 9180
RND1 9135
S100A8 9123
ZWINT 9112
SPDL1 9028
SPATA13 8981
CKB 8953
NDC80 8933
GJA1 8907
NUF2 8902
DIAPH3 8870
LMNB1 8850
TPM4 8847
H2AC6 8794
RACGAP1 8791
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
MPP7 8704

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 9180
RND1 9135
S100A8 9123
ZWINT 9112
SPDL1 9028
SPATA13 8981
CKB 8953
NDC80 8933
GJA1 8907
NUF2 8902
DIAPH3 8870
LMNB1 8850
TPM4 8847
H2AC6 8794
RACGAP1 8791
KIF18A 8767
BUB1B 8748
H2BC21 8730
BIRC5 8710
MPP7 8704
PCDH7 8701
RND3 8683
PRKCB 8675
KNTC1 8660
RHOBTB1 8642
ZAP70 8612
BUB1 8578
PRC1 8571
ECT2 8541
RASAL2 8514
MAD2L1 8490
IQGAP3 8486
ANLN 8400
TFRC 8396
KIF5A 8383
FGD3 8375
GNA13 8363
RAC2 8334
ARHGAP11B 8326
CENPU 8324
CENPF 8317
AURKB 8302
PPP2R1B 8292
ARHGAP9 8263
H2BC5 8216
ABI1 8160
SH3PXD2A 8158
CENPO 8144
SRGAP3 8120
SPC24 8118
TAGAP 8111
LIMK2 8053
TRIO 7976
MSI2 7947
CENPP 7938
H3-3A 7937
ARHGEF16 7894
CENPA 7870
DSG2 7866
ACBD5 7859
ACTN1 7788
DOCK10 7747
ABL2 7652
CENPN 7635
MYO6 7623
WDR91 7606
KDM4C 7591
KIF14 7587
CCDC88A 7579
LIMK1 7568
PLXNB1 7487
UHRF1BP1L 7456
FMNL2 7383
ITGB1 7377
ACTR3 7347
ZWILCH 7311
VAV3 7268
WDR11 7262
DOCK7 7238
CENPM 7233
KIDINS220 7206
NUP107 7149
YWHAQ 7139
STK38 7121
ANKLE2 7114
STBD1 7106
CALM1 7072
CENPK 7060
DOCK5 7037
NCF2 7035
DAAM1 7013
ITGB3BP 6916
CCP110 6913
CENPC 6905
KCTD3 6894
CDCA8 6887
CTNNB1 6885
CENPE 6840
UACA 6791
KIF5B 6745
H2AZ1 6727
ACTR2 6719
ARHGEF19 6705
SRGAP2 6649
ARHGAP11A 6615
BAIAP2L1 6580
CENPI 6571
DST 6518
ARHGAP28 6515
WIPF1 6477
PIK3CA 6452
H2AC18 6414
ARHGAP44 6354
CYFIP2 6304
KNL1 6300
YWHAG 6286
ARHGEF9 6278
NCKAP1 6268
RHOF 6259
AKAP13 6244
PICALM 6239
HSPE1 6164
ARHGEF39 6144
PKN2 6111
ABI2 6106
CDC20 6096
OCRL 5972
CAPZB 5943
MYL6 5941
WWP2 5940
SLC4A7 5922
DDX39B 5895
ROCK1 5832
MTR 5811
SHKBP1 5802
TMOD3 5780
ARMCX3 5766
ABCD3 5753
ARHGEF5 5698
DEF6 5689
CTTN 5675
TRA2B 5627
XPO1 5625
H2AZ2 5520
CENPQ 5514
TMEM87A 5497
BUB3 5458
SRGAP1 5444
VRK2 5417
FERMT2 5384
LEMD3 5367
STEAP3 5335
PPP1CB 5311
ARPC2 5282
SCFD1 5278
DLG5 5242
BASP1 5236
SWAP70 5221
ABR 5198
CHN1 5180
ERCC6L 5156
RAB7A 5077
TIAM2 5070
MAPRE1 5048
FMNL3 5046
ACTC1 5029
KALRN 5015
DVL3 4992
CDC42BPA 4972
FAM91A1 4944
NDE1 4928
PDPK1 4887
CEP97 4852
ARHGAP42 4849
DSN1 4816
PREX2 4805
ARHGAP25 4754
CCT2 4749
GMIP 4747
MAPK1 4733
NUP37 4625
NHS 4579
ROCK2 4560
GARRE1 4544
KTN1 4536
KIF2A 4530
TAOK3 4504
KLC2 4497
TAOK1 4480
SLK 4466
DOCK9 4437
SEH1L 4433
ARHGAP22 4427
PFN2 4401
PPP2R5A 4400
RAC3 4334
LRRC1 4327
AHCTF1 4308
RHOQ 4285
DYNC1I2 4284
PAFAH1B1 4255
KIF2C 4231
MOSPD2 4154
MACO1 4127
NDUFA5 4124
STAM 4117
SNAP23 4072
ARPC3 4051
GOLGA8R 4045
PPP2CA 4034
ARHGAP32 4017
ZW10 4008
DYNC1LI2 4005
DLC1 3998
CENPH 3875
ARHGEF12 3816
NCOA2 3804
H2BU1 3777
COPS2 3744
SKA1 3729
DOCK4 3701
STK10 3680
PRKCA 3672
SRF 3647
CLASP2 3637
FNBP1L 3562
PARD6B 3509
PPP2R5C 3488
WASL 3461
CKAP5 3402
TNFAIP1 3327
SH3RF1 3263
GIT2 3219
PLK1 3164
YWHAZ 3108
SGO2 3092
PRKCZ 3055
PLEKHG2 3052
MYL12B 3029
ARPC5 2999
PAK1 2998
SOWAHC 2944
RHOD 2941
ARHGAP12 2937
SLC1A5 2918
TPM3 2840
RHOJ 2833
PPP2CB 2822
CLIP1 2815
NUP160 2749
CYFIP1 2740
CUL3 2724
DYNC1LI1 2713
FRS2 2656
SPC25 2593
PPP2R5B 2592
IQGAP1 2530
PIN1 2523
ARHGEF6 2514
TJP2 2510
RALGAPA1 2491
CFL1 2483
LBR 2457
CDC42SE2 2422
NUP85 2385
SYDE2 2355
ARFGAP3 2348
PTK2B 2242
RASGRF2 2236
PPP1R12A 2230
CIT 2190
DSP 2130
NDEL1 2105
EPSTI1 2028
VANGL1 2026
ARHGEF3 2019
RBMX 1981
TXNL1 1953
RALBP1 1911
CENPL 1908
FARP1 1889
PAK2 1875
PKN3 1873
NSL1 1865
KLC1 1849
CLASP1 1830
MTX1 1829
PLEKHG3 1826
SKA2 1817
CTNNA1 1815
ERBIN 1809
ARHGAP29 1777
BTK 1744
GOLGA3 1701
ARAP3 1679
SCAI 1620
DYNLL1 1561
CDC42EP3 1552
ARL13B 1551
YWHAE 1494
DLG4 1474
HNRNPC 1458
RND2 1363
DOCK1 1351
ELMO2 1306
H2BC4 1261
DIAPH1 1251
PLEKHG1 1202
EMC3 1193
CENPT 1162
ARHGEF10 1150
RANBP2 1105
ALS2 1050
MIS12 1040
FAM135A 945
CCT6A 894
B9D2 872
NGEF 855
H2AJ 847
HSP90AA1 820
LETM1 805
SOS2 803
LCK 766
ANKRD26 717
CPD 682
CDC37 673
DOCK11 671
ARHGAP10 613
JAG1 584
ARHGDIB 557
PLD1 545
DDRGK1 518
GOPC 492
EPHA2 449
RBBP6 394
OSBPL11 393
TUBA1B 379
ACTG1 355
HSP90AB1 348
C1QBP 314
FLNA 287
PLXNA1 269
ARHGAP21 261
PFN1 246
PEAK1 214
GFOD1 203
EVL 114
ARHGAP35 94
MCF2L 92
MTMR1 43
NDUFS3 -33
KLC4 -111
AMIGO2 -122
SAMM50 -147
TAX1BP3 -176
CDC42 -229
SEC13 -240
IL32 -249
EMD -259
LIN7B -319
TWF1 -321
NISCH -338
TOR1AIP1 -370
USP9X -388
CCT7 -407
BCAP31 -409
FAM13A -467
KDM1A -580
ARPC1B -597
PMF1 -611
RHOH -621
MAPK14 -684
RHOC -685
FGD1 -701
DOCK8 -750
FLOT1 -754
DBT -755
ARHGAP30 -783
PIK3C3 -793
SOS1 -829
PLD2 -850
WHAMM -855
ARHGEF25 -881
YWHAB -909
PREX1 -941
STAM2 -991
ARHGAP24 -997
MYO9B -1009
DYNC1H1 -1028
CDKN1B -1066
VIM -1071
RHPN2 -1104
ARHGAP15 -1119
FAF2 -1169
BAIAP2L2 -1191
ARHGAP19 -1239
ARHGEF40 -1242
RAPGEF1 -1286
STARD13 -1365
ATP6AP1 -1376
CPNE8 -1400
YKT6 -1408
STIP1 -1459
PPP1CC -1467
LMAN1 -1480
OBSCN -1483
PIK3R2 -1500
DYNC1I1 -1561
BRK1 -1584
ARHGEF28 -1642
COPS4 -1660
VCP -1676
PKP4 -1712
NUP43 -1806
RHOA -1834
MAD1L1 -1976
PPP2R5E -2059
ARHGAP5 -2073
SENP1 -2093
NCK1 -2177
NCKIPSD -2186
DVL1 -2189
WIPF2 -2197
ARHGEF7 -2232
RTKN -2241
CPSF7 -2272
DOCK6 -2276
PRKCD -2334
SEMA4F -2339
ARHGEF11 -2377
ARHGEF17 -2394
NSFL1C -2441
ARHGAP31 -2460
CLTC -2520
FARP2 -2538
ARAP1 -2551
ARHGAP1 -2597
RNF20 -2714
MYH14 -2755
NCK2 -2759
ARHGAP39 -2967
MCAM -3029
ARHGEF15 -3046
SPEN -3218
VAMP3 -3248
ACTB -3297
RCC2 -3305
HMOX2 -3338
RHOBTB2 -3365
PTPN13 -3391
WDR6 -3419
GPS1 -3434
ARPC4 -3439
HGS -3555
TMPO -3596
ITSN2 -3617
NUP133 -3621
ARHGAP33 -3773
ARHGAP26 -3827
ARAP2 -3874
PGRMC2 -3973
CKAP4 -3974
CAV1 -3989
FNBP1 -4010
INCENP -4011
DEPDC1B -4107
SFN -4148
MYLK -4236
CYBA -4304
CCDC115 -4313
DVL2 -4322
ADD3 -4364
ITSN1 -4390
ZNF512B -4418
HINT2 -4497
PPP2R5D -4551
ANKFY1 -4557
ARHGAP27 -4558
EFHD2 -4570
ARHGEF1 -4574
UBXN11 -4577
RHOB -4591
PTK2 -4681
AAAS -4689
JUP -4695
YWHAH -4728
PPP1R12B -4730
STOM -4738
GRB2 -4777
NCKAP1L -4809
TEX2 -4878
SHMT2 -4911
PLEKHG6 -4964
WASF3 -4974
LAMTOR1 -5031
MYH9 -5033
KCTD13 -5036
RRAS2 -5057
TMEM59 -5099
SRRM1 -5119
NCF4 -5177
VAPB -5213
CDC42BPB -5274
MYO9A -5324
RAC1 -5383
STMN2 -5392
ARHGAP8 -5404
PAK4 -5405
ARHGAP18 -5411
RPS27 -5510
RANGAP1 -5521
ABL1 -5571
PLEKHG4 -5624
VAV2 -5663
TIAM1 -5718
BAIAP2 -5727
DOCK3 -5796
STX5 -5873
CDC42EP5 -5882
NUDC -5900
MYH10 -5926
PHIP -5943
PARD6A -5985
FMNL1 -6008
WASF2 -6027
ARHGAP4 -6032
SRC -6078
PIK3R4 -6113
ESYT1 -6116
OPHN1 -6123
ARHGAP17 -6127
MAPK11 -6182
PLXND1 -6204
SPTAN1 -6243
H2BC12 -6254
WDR81 -6270
NUP98 -6316
WAS -6425
FAM13B -6477
SYDE1 -6618
VANGL2 -6640
ARHGEF2 -6645
RHOG -6703
FILIP1 -6732
SCRIB -6783
FGD5 -6826
DYNLL2 -6837
DOCK2 -6866
PKN1 -6903
MAPK3 -6930
DBN1 -6947
WIPF3 -6964
ARHGDIA -7018
FRS3 -7062
GIT1 -7068
ARFGAP2 -7079
TRIP10 -7249
ARHGEF18 -7376
PPP2R1A -7410
WASF1 -7416
PLEKHG5 -7526
AR -7550
SPTBN1 -7560
NF2 -7562
ARHGEF26 -7598
ARHGEF4 -7621
MYH11 -7731
IQGAP2 -7736
NET1 -7764
ALDH3A2 -7866
MEN1 -7898
CDC42EP1 -7907
DIAPH2 -7909
FGD4 -7930
PPP1R14A -7952
CYBB -7976
ARPC1A -7978
STARD8 -8001
PDE5A -8030
NCF1 -8038
ARHGAP23 -8056
MYL9 -8062
CDC42EP2 -8081
CSK -8169
FLOT2 -8318
ARHGAP6 -8344
NOXA1 -8368
GRB7 -8374
ARHGEF10L -8385
VAV1 -8460
SH3BP1 -8471
MAP3K11 -8512
MRTFA -8646
PIK3R3 -8805
CDC42EP4 -8826
BCR -8902
FGD2 -8940
RHOU -8978
DNMBP -9019
CHN2 -9057
RHPN1 -9065
ARHGAP20 -9067
PAK3 -9092
AKAP12 -9144
PIK3R1 -9386


Deposition of new CENPA-containing nucleosomes at the centromere

Deposition of new CENPA-containing nucleosomes at the centromere
290
set Deposition of new CENPA-containing nucleosomes at the centromere
setSize 36
pANOVA 1.36e-06
s.dist 0.465
p.adjustANOVA 4e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC6 8794
H2BC21 8730
HJURP 8506
CENPU 8324
H2BC5 8216
CENPO 8144
CENPP 7938
CENPA 7870
CENPN 7635
CENPW 7594
CENPM 7233
CENPK 7060
ITGB3BP 6916
CENPC 6905
H2AZ1 6727
CENPI 6571
H2AC18 6414
KNL1 6300
H2AZ2 5520
CENPQ 5514

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 8794
H2BC21 8730
HJURP 8506
CENPU 8324
H2BC5 8216
CENPO 8144
CENPP 7938
CENPA 7870
CENPN 7635
CENPW 7594
CENPM 7233
CENPK 7060
ITGB3BP 6916
CENPC 6905
H2AZ1 6727
CENPI 6571
H2AC18 6414
KNL1 6300
H2AZ2 5520
CENPQ 5514
MIS18BP1 4411
CENPH 3875
H2BU1 3777
RBBP7 3467
CENPL 1908
H2BC4 1261
CENPT 1162
NPM1 985
H2AJ 847
RUVBL1 -35
RBBP4 -106
SMARCA5 -977
RSF1 -1230
OIP5 -4115
MIS18A -5063
H2BC12 -6254


Nucleosome assembly

Nucleosome assembly
780
set Nucleosome assembly
setSize 36
pANOVA 1.36e-06
s.dist 0.465
p.adjustANOVA 4e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC6 8794
H2BC21 8730
HJURP 8506
CENPU 8324
H2BC5 8216
CENPO 8144
CENPP 7938
CENPA 7870
CENPN 7635
CENPW 7594
CENPM 7233
CENPK 7060
ITGB3BP 6916
CENPC 6905
H2AZ1 6727
CENPI 6571
H2AC18 6414
KNL1 6300
H2AZ2 5520
CENPQ 5514

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC6 8794
H2BC21 8730
HJURP 8506
CENPU 8324
H2BC5 8216
CENPO 8144
CENPP 7938
CENPA 7870
CENPN 7635
CENPW 7594
CENPM 7233
CENPK 7060
ITGB3BP 6916
CENPC 6905
H2AZ1 6727
CENPI 6571
H2AC18 6414
KNL1 6300
H2AZ2 5520
CENPQ 5514
MIS18BP1 4411
CENPH 3875
H2BU1 3777
RBBP7 3467
CENPL 1908
H2BC4 1261
CENPT 1162
NPM1 985
H2AJ 847
RUVBL1 -35
RBBP4 -106
SMARCA5 -977
RSF1 -1230
OIP5 -4115
MIS18A -5063
H2BC12 -6254


Fcgamma receptor (FCGR) dependent phagocytosis

Fcgamma receptor (FCGR) dependent phagocytosis
402
set Fcgamma receptor (FCGR) dependent phagocytosis
setSize 119
pANOVA 1.51e-06
s.dist -0.255
p.adjustANOVA 4.35e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9413
IGHV1-2 -9408
PIK3R1 -9386
IGHV3-30 -9344
IGLV2-14 -9330
IGKV1-5 -9324
IGLC2 -9238
IGLV3-25 -9227
IGLV3-21 -9180
IGHV3-23 -9173
FYN -9165
IGKV4-1 -9151
IGLV1-47 -9148
IGLV1-40 -9126
IGLV2-11 -9099
IGHG2 -9096
IGKV3-20 -9063
IGLV2-8 -9051
FCGR3A -9018
IGHG3 -9014
IGHG1 -8994
IGHV2-5 -8925
IGLV1-51 -8906
IGHG4 -8851
IGLC3 -8828
IGLV2-23 -8686
IGKC -8678
IGKV1D-39 -8562
IGHV4-59 -8467
VAV1 -8460
IGLV3-1 -8321
IGHV3-13 -8306
IGLC1 -8206
FCGR2A -8132
ARPC1A -7978
IGKV3-15 -7850
IGLV1-44 -7694
NF2 -7562
WASF1 -7416
SYK -7360
WIPF3 -6964
MAPK3 -6930
IGHV3-33 -6656
WAS -6425
PLD3 -6310
SRC -6078
WASF2 -6027
BAIAP2 -5727
VAV2 -5663
ABL1 -5571
RAC1 -5383
ELMO1 -5355
MYH9 -5033
WASF3 -4974
NCKAP1L -4809
GRB2 -4777
HCK -4732
PTK2 -4681
PLCG2 -4620
MYO1C -3516
ARPC4 -3439
ACTB -3297
IGKV1-33 -2600
PRKCD -2334
WIPF2 -2197
NCKIPSD -2186
NCK1 -2177
BRK1 -1584
PIK3R2 -1500
MYH2 -1279
CRK -1031
MYO9B -1009
PLA2G6 -865
PLD2 -850
ARPC1B -597
PLD4 -577
CDC42 -229
HSP90AB1 348
ACTG1 355
ITPR3 513
PLD1 545
FCGR1A 592
PLCG1 819
HSP90AA1 820
ELMO2 1306
DOCK1 1351
BTK 1744
AHCYL1 2038
PRKCE 2352
LYN 2420
CFL1 2483
CYFIP1 2740
PAK1 2998
ARPC5 2999
CD3G 3144
WASL 3461
MYO5A 3735
ARPC3 4051
PLPP5 4414
MAPK1 4733
ARPC2 5282
YES1 5910
ABI2 6106
NCKAP1 6268
CYFIP2 6304
PIK3CA 6452
WIPF1 6477
ACTR2 6719
VAV3 7268
ACTR3 7347
PIK3CB 7464
FGR 7542
LIMK1 7568
ABI1 8160
PLPP4 8345
ITPR2 8466
ITPR1 8491
MYO10 8927
CD247 8946


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] beeswarm_0.4.0              gtools_3.9.2               
##  [5] echarts4r_0.4.3             kableExtra_1.3.4           
##  [7] topconfects_1.8.0           limma_3.48.3               
##  [9] eulerr_6.1.1                mitch_1.4.1                
## [11] MASS_7.3-56                 fgsea_1.18.0               
## [13] gplots_3.1.1                DESeq2_1.32.0              
## [15] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [17] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [19] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [21] IRanges_2.26.0              S4Vectors_0.30.2           
## [23] BiocGenerics_0.38.0         reshape2_1.4.4             
## [25] forcats_0.5.1               stringr_1.4.0              
## [27] dplyr_1.0.8                 purrr_0.3.4                
## [29] readr_2.1.2                 tidyr_1.2.0                
## [31] tibble_3.1.6                ggplot2_3.3.5              
## [33] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-3       ellipsis_0.3.2         rprojroot_2.0.2       
##   [4] XVector_0.32.0         fs_1.5.2               rstudioapi_0.13       
##   [7] bit64_4.0.5            AnnotationDbi_1.54.1   fansi_1.0.2           
##  [10] lubridate_1.8.0        xml2_1.3.3             splines_4.2.0         
##  [13] cachem_1.0.6           geneplotter_1.70.0     knitr_1.37            
##  [16] jsonlite_1.8.0         broom_0.7.12           annotate_1.70.0       
##  [19] dbplyr_2.1.1           png_0.1-7              shiny_1.7.1           
##  [22] compiler_4.2.0         httr_1.4.2             backports_1.4.1       
##  [25] assertthat_0.2.1       Matrix_1.4-1           fastmap_1.1.0         
##  [28] cli_3.2.0              later_1.3.0            htmltools_0.5.2       
##  [31] tools_4.2.0            gtable_0.3.0           glue_1.6.2            
##  [34] GenomeInfoDbData_1.2.6 fastmatch_1.1-3        Rcpp_1.0.8.2          
##  [37] cellranger_1.1.0       jquerylib_0.1.4        vctrs_0.3.8           
##  [40] Biostrings_2.60.2      svglite_2.1.0          xfun_0.30             
##  [43] rvest_1.0.2            mime_0.12              lifecycle_1.0.1       
##  [46] XML_3.99-0.9           zlibbioc_1.38.0        scales_1.1.1          
##  [49] promises_1.2.0.1       hms_1.1.1              RColorBrewer_1.1-2    
##  [52] yaml_2.3.5             gridExtra_2.3          memoise_2.0.1         
##  [55] sass_0.4.0             reshape_0.8.8          stringi_1.7.6         
##  [58] RSQLite_2.2.10         highr_0.9              genefilter_1.74.1     
##  [61] desc_1.4.1             caTools_1.18.2         BiocParallel_1.26.2   
##  [64] systemfonts_1.0.4      rlang_1.0.2            pkgconfig_2.0.3       
##  [67] bitops_1.0-7           evaluate_0.15          lattice_0.20-45       
##  [70] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.1.2      
##  [73] plyr_1.8.6             magrittr_2.0.2         R6_2.5.1              
##  [76] generics_0.1.2         DelayedArray_0.18.0    DBI_1.1.2             
##  [79] pillar_1.7.0           haven_2.4.3            withr_2.5.0           
##  [82] survival_3.3-1         KEGGREST_1.32.0        RCurl_1.98-1.6        
##  [85] modelr_0.1.8           crayon_1.5.0           KernSmooth_2.23-20    
##  [88] utf8_1.2.2             tzdb_0.2.0             rmarkdown_2.13        
##  [91] locfit_1.5-9.5         grid_4.2.0             readxl_1.3.1          
##  [94] data.table_1.14.2      blob_1.2.2             webshot_0.5.2         
##  [97] reprex_2.0.1           digest_0.6.29          xtable_1.8-4          
## [100] httpuv_1.6.5           munsell_0.5.0          viridisLite_0.4.0     
## [103] bslib_0.3.1

END of report