Mitch Report

date generated: 2022-05-11

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     x
## 5_8S_rRNA  0.17560000
## A1BG       0.62426514
## A2M        1.00371658
## A2M-AS1    0.55048686
## A4GALT     0.01402314
## AAAS      -0.11217837

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2512
num_genes_in_profile	15898
duplicated_genes_present	0
num_profile_genes_in_sets	8067
num_profile_genes_not_in_sets	7831

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2512
num_genesets_excluded	1101
num_genesets_included	1411

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
Classical antibody-mediated complement activation	49	7.86e-23	-0.811	1.11e-19
Creation of C4 and C2 activators	53	3.63e-22	-0.768	2.35e-19
Scavenging of heme from plasma	49	4.99e-22	-0.796	2.35e-19
FCGR activation	54	9.72e-22	-0.753	3.43e-19
CD22 mediated BCR regulation	46	8.68e-20	-0.775	2.45e-17
Initial triggering of complement	59	3.65e-18	-0.654	8.58e-16
Regulation of Complement cascade	72	6.86e-18	-0.587	1.38e-15
Role of LAT2/NTAL/LAB on calcium mobilization	53	1.63e-17	-0.676	2.87e-15
Complement cascade	77	3.33e-17	-0.556	5.23e-15
Binding and Uptake of Ligands by Scavenger Receptors	75	7.75e-17	-0.556	1.09e-14
Role of phospholipids in phagocytosis	65	8.01e-16	-0.577	1.03e-13
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	69	1.45e-15	-0.555	1.71e-13
Metabolism of RNA	676	2.55e-14	0.173	2.77e-12
FCERI mediated Ca+2 mobilization	67	4.38e-14	-0.533	4.41e-12
FCGR3A-mediated IL10 synthesis	77	1.45e-13	-0.487	1.36e-11
FCGR3A-mediated phagocytosis	102	3.13e-12	-0.400	2.46e-10
Leishmania phagocytosis	102	3.13e-12	-0.400	2.46e-10
Parasite infection	102	3.13e-12	-0.400	2.46e-10
FCERI mediated MAPK activation	69	3.98e-12	-0.483	2.95e-10
Cell surface interactions at the vascular wall	146	7.01e-11	-0.313	4.94e-09
Regulation of actin dynamics for phagocytic cup formation	103	1.60e-10	-0.365	1.07e-08
Translation	293	5.85e-10	0.211	3.75e-08
rRNA processing	213	1.30e-09	0.242	7.95e-08
Developmental Biology	726	1.72e-09	0.132	1.01e-07
Regulation of expression of SLITs and ROBOs	160	2.48e-09	0.273	1.40e-07
Fcgamma receptor (FCGR) dependent phagocytosis	126	8.84e-09	-0.297	4.80e-07
Nervous system development	479	1.27e-08	0.152	6.65e-07
Cellular responses to stimuli	663	2.43e-08	0.128	1.23e-06
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	111	3.05e-08	-0.304	1.48e-06
Cellular responses to stress	657	3.47e-08	0.127	1.63e-06
Axon guidance	456	3.62e-08	0.151	1.65e-06
Anti-inflammatory response favouring Leishmania parasite infection	132	4.08e-08	-0.277	1.74e-06
Leishmania parasite growth and survival	132	4.08e-08	-0.277	1.74e-06
Cap-dependent Translation Initiation	117	6.37e-08	0.290	2.57e-06
Eukaryotic Translation Initiation	117	6.37e-08	0.290	2.57e-06
Formation of a pool of free 40S subunits	99	8.95e-08	0.311	3.51e-06
Eukaryotic Translation Elongation	92	9.78e-08	0.322	3.73e-06
Hemostasis	501	1.13e-07	-0.139	4.18e-06
L13a-mediated translational silencing of Ceruloplasmin expression	109	1.54e-07	0.291	5.57e-06
GTP hydrolysis and joining of the 60S ribosomal subunit	110	1.76e-07	0.288	6.21e-06
Influenza Viral RNA Transcription and Replication	134	4.69e-07	0.252	1.61e-05
Interferon alpha/beta signaling	56	7.18e-07	0.383	2.41e-05
Peptide chain elongation	87	7.84e-07	0.306	2.57e-05
Signaling by ROBO receptors	202	9.88e-07	0.200	3.17e-05
rRNA processing in the nucleus and cytosol	189	1.24e-06	0.205	3.87e-05
Eukaryotic Translation Termination	91	1.52e-06	0.292	4.67e-05
Influenza Infection	153	1.63e-06	0.225	4.89e-05
Interferon Signaling	173	1.73e-06	0.211	5.08e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	1.77e-06	0.287	5.09e-05
Viral mRNA Translation	87	1.83e-06	0.296	5.17e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Classical antibody-mediated complement activation	49	7.86e-23	-8.11e-01	1.11e-19
Creation of C4 and C2 activators	53	3.63e-22	-7.68e-01	2.35e-19
Scavenging of heme from plasma	49	4.99e-22	-7.96e-01	2.35e-19
FCGR activation	54	9.72e-22	-7.53e-01	3.43e-19
CD22 mediated BCR regulation	46	8.68e-20	-7.75e-01	2.45e-17
Initial triggering of complement	59	3.65e-18	-6.54e-01	8.58e-16
Regulation of Complement cascade	72	6.86e-18	-5.87e-01	1.38e-15
Role of LAT2/NTAL/LAB on calcium mobilization	53	1.63e-17	-6.76e-01	2.87e-15
Complement cascade	77	3.33e-17	-5.56e-01	5.23e-15
Binding and Uptake of Ligands by Scavenger Receptors	75	7.75e-17	-5.56e-01	1.09e-14
Role of phospholipids in phagocytosis	65	8.01e-16	-5.77e-01	1.03e-13
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	69	1.45e-15	-5.55e-01	1.71e-13
Metabolism of RNA	676	2.55e-14	1.73e-01	2.77e-12
FCERI mediated Ca+2 mobilization	67	4.38e-14	-5.33e-01	4.41e-12
FCGR3A-mediated IL10 synthesis	77	1.45e-13	-4.87e-01	1.36e-11
FCGR3A-mediated phagocytosis	102	3.13e-12	-4.00e-01	2.46e-10
Leishmania phagocytosis	102	3.13e-12	-4.00e-01	2.46e-10
Parasite infection	102	3.13e-12	-4.00e-01	2.46e-10
FCERI mediated MAPK activation	69	3.98e-12	-4.83e-01	2.95e-10
Cell surface interactions at the vascular wall	146	7.01e-11	-3.13e-01	4.94e-09
Regulation of actin dynamics for phagocytic cup formation	103	1.60e-10	-3.65e-01	1.07e-08
Translation	293	5.85e-10	2.11e-01	3.75e-08
rRNA processing	213	1.30e-09	2.42e-01	7.95e-08
Developmental Biology	726	1.72e-09	1.32e-01	1.01e-07
Regulation of expression of SLITs and ROBOs	160	2.48e-09	2.73e-01	1.40e-07
Fcgamma receptor (FCGR) dependent phagocytosis	126	8.84e-09	-2.97e-01	4.80e-07
Nervous system development	479	1.27e-08	1.52e-01	6.65e-07
Cellular responses to stimuli	663	2.43e-08	1.28e-01	1.23e-06
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	111	3.05e-08	-3.04e-01	1.48e-06
Cellular responses to stress	657	3.47e-08	1.27e-01	1.63e-06
Axon guidance	456	3.62e-08	1.51e-01	1.65e-06
Anti-inflammatory response favouring Leishmania parasite infection	132	4.08e-08	-2.77e-01	1.74e-06
Leishmania parasite growth and survival	132	4.08e-08	-2.77e-01	1.74e-06
Cap-dependent Translation Initiation	117	6.37e-08	2.90e-01	2.57e-06
Eukaryotic Translation Initiation	117	6.37e-08	2.90e-01	2.57e-06
Formation of a pool of free 40S subunits	99	8.95e-08	3.11e-01	3.51e-06
Eukaryotic Translation Elongation	92	9.78e-08	3.22e-01	3.73e-06
Hemostasis	501	1.13e-07	-1.39e-01	4.18e-06
L13a-mediated translational silencing of Ceruloplasmin expression	109	1.54e-07	2.91e-01	5.57e-06
GTP hydrolysis and joining of the 60S ribosomal subunit	110	1.76e-07	2.88e-01	6.21e-06
Influenza Viral RNA Transcription and Replication	134	4.69e-07	2.52e-01	1.61e-05
Interferon alpha/beta signaling	56	7.18e-07	3.83e-01	2.41e-05
Peptide chain elongation	87	7.84e-07	3.06e-01	2.57e-05
Signaling by ROBO receptors	202	9.88e-07	2.00e-01	3.17e-05
rRNA processing in the nucleus and cytosol	189	1.24e-06	2.05e-01	3.87e-05
Eukaryotic Translation Termination	91	1.52e-06	2.92e-01	4.67e-05
Influenza Infection	153	1.63e-06	2.25e-01	4.89e-05
Interferon Signaling	173	1.73e-06	2.11e-01	5.08e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	1.77e-06	2.87e-01	5.09e-05
Viral mRNA Translation	87	1.83e-06	2.96e-01	5.17e-05
Selenocysteine synthesis	91	2.81e-06	2.84e-01	7.77e-05
Major pathway of rRNA processing in the nucleolus and cytosol	179	3.23e-06	2.02e-01	8.76e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	3.75e-06	2.52e-01	9.81e-05
Nonsense-Mediated Decay (NMD)	113	3.75e-06	2.52e-01	9.81e-05
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	4.08e-06	2.68e-01	1.03e-04
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	4.08e-06	3.66e-01	1.03e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	4.39e-06	3.65e-01	1.09e-04
rRNA processing in the mitochondrion	24	9.58e-06	5.22e-01	2.30e-04
Autodegradation of Cdh1 by Cdh1:APC/C	64	9.61e-06	3.20e-01	2.30e-04
Degradation of DVL	55	1.14e-05	3.42e-01	2.67e-04
Leishmania infection	211	1.17e-05	-1.75e-01	2.71e-04
Dectin-1 mediated noncanonical NF-kB signaling	58	1.38e-05	3.30e-01	3.14e-04
ROS sensing by NFE2L2	55	1.45e-05	3.38e-01	3.25e-04
Selenoamino acid metabolism	113	1.48e-05	2.36e-01	3.26e-04
Chromatin modifying enzymes	211	1.62e-05	1.73e-01	3.45e-04
Chromatin organization	211	1.62e-05	1.73e-01	3.45e-04
Regulation of HMOX1 expression and activity	63	1.72e-05	3.13e-01	3.63e-04
NIK–>noncanonical NF-kB signaling	57	1.95e-05	3.27e-01	4.06e-04
Synthesis of DNA	110	2.05e-05	2.35e-01	4.19e-04
Cellular response to starvation	148	2.35e-05	2.02e-01	4.73e-04
Asymmetric localization of PCP proteins	62	2.55e-05	3.09e-01	5.07e-04
Cytosolic sensors of pathogen-associated DNA	61	2.60e-05	3.11e-01	5.10e-04
Processing of Capped Intron-Containing Pre-mRNA	238	2.95e-05	1.57e-01	5.63e-04
Metabolism of polyamines	56	2.95e-05	3.23e-01	5.63e-04
Autodegradation of the E3 ubiquitin ligase COP1	49	3.97e-05	3.39e-01	7.46e-04
Vif-mediated degradation of APOBEC3G	52	4.31e-05	3.28e-01	8.01e-04
SCF(Skp2)-mediated degradation of p27/p21	57	5.21e-05	3.10e-01	9.55e-04
Hedgehog ligand biogenesis	58	5.33e-05	3.07e-01	9.64e-04
Negative regulation of NOTCH4 signaling	54	5.48e-05	3.17e-01	9.78e-04
Switching of origins to a post-replicative state	85	5.78e-05	2.52e-01	1.01e-03
DNA Replication	130	5.82e-05	2.04e-01	1.01e-03
Interleukin-1 signaling	96	5.87e-05	2.37e-01	1.01e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	6.22e-05	3.34e-01	1.05e-03
Degradation of GLI1 by the proteasome	57	6.23e-05	3.07e-01	1.05e-03
Orc1 removal from chromatin	66	7.19e-05	2.83e-01	1.19e-03
Hh mutants abrogate ligand secretion	54	7.82e-05	3.11e-01	1.28e-03
mRNA Splicing	187	8.14e-05	1.67e-01	1.32e-03
CDK-mediated phosphorylation and removal of Cdc6	68	8.42e-05	2.76e-01	1.35e-03
The role of GTSE1 in G2/M progression after G2 checkpoint	56	9.04e-05	3.03e-01	1.43e-03
Hh mutants are degraded by ERAD	53	9.13e-05	3.11e-01	1.43e-03
SRP-dependent cotranslational protein targeting to membrane	110	9.30e-05	2.16e-01	1.44e-03
Regulation of ornithine decarboxylase (ODC)	48	9.69e-05	3.25e-01	1.49e-03
Transcriptional regulation by RUNX3	93	1.18e-04	2.31e-01	1.78e-03
DNA Replication Pre-Initiation	91	1.35e-04	2.32e-01	2.01e-03
PTEN Regulation	136	1.35e-04	1.90e-01	2.01e-03
Ubiquitin-dependent degradation of Cyclin D	50	1.37e-04	3.12e-01	2.01e-03
Vpu mediated degradation of CD4	50	1.46e-04	3.11e-01	2.09e-03
Cytoprotection by HMOX1	117	1.46e-04	2.03e-01	2.09e-03
Assembly of the pre-replicative complex	79	1.46e-04	2.47e-01	2.09e-03
PCP/CE pathway	86	1.56e-04	2.36e-01	2.20e-03
APC/C:Cdc20 mediated degradation of Securin	66	1.62e-04	2.69e-01	2.24e-03
mRNA Splicing - Major Pathway	179	1.63e-04	1.64e-01	2.24e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	68	1.65e-04	2.64e-01	2.24e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	68	1.65e-04	2.64e-01	2.24e-03
Signaling by NOTCH4	81	2.03e-04	2.39e-01	2.70e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	2.07e-04	3.06e-01	2.70e-03
p53-Independent DNA Damage Response	49	2.07e-04	3.06e-01	2.70e-03
p53-Independent G1/S DNA damage checkpoint	49	2.07e-04	3.06e-01	2.70e-03
Regulation of Apoptosis	51	2.24e-04	2.99e-01	2.90e-03
SCF-beta-TrCP mediated degradation of Emi1	53	2.27e-04	2.93e-01	2.92e-03
Degradation of GLI2 by the proteasome	57	2.35e-04	2.82e-01	2.98e-03
Regulation of RUNX3 expression and activity	54	2.36e-04	2.89e-01	2.98e-03
ABC transporter disorders	70	2.91e-04	2.51e-01	3.63e-03
TNFR2 non-canonical NF-kB pathway	81	2.97e-04	2.33e-01	3.68e-03
p53-Dependent G1 DNA Damage Response	60	3.14e-04	2.69e-01	3.82e-03
p53-Dependent G1/S DNA damage checkpoint	60	3.14e-04	2.69e-01	3.82e-03
Host Interactions of HIV factors	125	3.30e-04	1.86e-01	3.98e-03
HIV Infection	220	3.43e-04	1.40e-01	4.10e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	70	3.55e-04	2.47e-01	4.21e-03
Stabilization of p53	53	3.63e-04	2.83e-01	4.27e-03
HATs acetylate histones	88	3.94e-04	2.19e-01	4.60e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	71	4.06e-04	2.43e-01	4.67e-03
Transcriptional regulation by RUNX1	174	4.07e-04	1.56e-01	4.67e-03
Degradation of AXIN	53	4.18e-04	2.80e-01	4.76e-03
MAPK6/MAPK4 signaling	83	4.49e-04	2.23e-01	5.07e-03
Striated Muscle Contraction	33	4.62e-04	3.52e-01	5.17e-03
Ribosomal scanning and start codon recognition	58	4.74e-04	2.65e-01	5.25e-03
Cross-presentation of soluble exogenous antigens (endosomes)	45	4.77e-04	3.01e-01	5.25e-03
UCH proteinases	86	5.23e-04	2.17e-01	5.72e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs	78	5.97e-04	2.25e-01	6.48e-03
G1/S DNA Damage Checkpoints	61	6.03e-04	2.54e-01	6.48e-03
ER-Phagosome pathway	85	6.06e-04	2.15e-01	6.48e-03
Translation initiation complex formation	58	6.34e-04	2.59e-01	6.71e-03
Signaling by NOTCH	180	6.37e-04	1.48e-01	6.71e-03
Defective CFTR causes cystic fibrosis	58	6.61e-04	2.59e-01	6.91e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	71	7.11e-04	2.32e-01	7.38e-03
ABC-family proteins mediated transport	91	7.32e-04	2.05e-01	7.54e-03
GLI3 is processed to GLI3R by the proteasome	57	7.98e-04	2.57e-01	8.16e-03
HCMV Infection	92	8.63e-04	2.01e-01	8.76e-03
NGF-stimulated transcription	33	8.69e-04	3.35e-01	8.76e-03
Cellular response to chemical stress	149	8.91e-04	1.58e-01	8.92e-03
CDT1 association with the CDC6:ORC:origin complex	55	9.09e-04	2.59e-01	9.03e-03
Signaling by the B Cell Receptor (BCR)	146	9.57e-04	-1.59e-01	9.44e-03
FCERI mediated NF-kB activation	115	9.85e-04	-1.78e-01	9.66e-03
Activation of NF-kappaB in B cells	65	1.02e-03	2.36e-01	9.96e-03
HSF1-dependent transactivation	33	1.04e-03	3.30e-01	1.00e-02
Metabolism of amino acids and derivatives	314	1.15e-03	1.07e-01	1.11e-02
Downstream TCR signaling	92	1.17e-03	1.96e-01	1.12e-02
TCF dependent signaling in response to WNT	162	1.19e-03	1.48e-01	1.13e-02
Regulation of innate immune responses to cytosolic DNA	14	1.20e-03	5.00e-01	1.13e-02
Smooth Muscle Contraction	34	1.22e-03	3.20e-01	1.13e-02
Regulation of APC/C activators between G1/S and early anaphase	76	1.22e-03	2.15e-01	1.13e-02
Formation of the ternary complex, and subsequently, the 43S complex	51	1.23e-03	2.62e-01	1.13e-02
Antiviral mechanism by IFN-stimulated genes	80	1.27e-03	2.08e-01	1.17e-02
Antimicrobial peptides	30	1.32e-03	-3.39e-01	1.20e-02
Innate Immune System	902	1.38e-03	-6.33e-02	1.25e-02
Cellular response to hypoxia	71	1.44e-03	2.19e-01	1.29e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.46e-03	2.40e-01	1.30e-02
Downstream signaling events of B Cell Receptor (BCR)	78	1.46e-03	2.09e-01	1.30e-02
DNA Damage Recognition in GG-NER	38	1.58e-03	2.96e-01	1.39e-02
APC/C-mediated degradation of cell cycle proteins	81	1.61e-03	2.03e-01	1.40e-02
Regulation of mitotic cell cycle	81	1.61e-03	2.03e-01	1.40e-02
Hedgehog ‘off’ state	95	1.70e-03	1.86e-01	1.47e-02
Interleukin-1 family signaling	122	1.74e-03	1.64e-01	1.50e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	1.78e-03	3.61e-01	1.53e-02
Nucleotide Excision Repair	109	1.89e-03	1.72e-01	1.60e-02
Pausing and recovery of Tat-mediated HIV elongation	30	1.91e-03	3.28e-01	1.60e-02
Tat-mediated HIV elongation arrest and recovery	30	1.91e-03	3.28e-01	1.60e-02
Apoptosis	160	2.09e-03	1.41e-01	1.74e-02
tRNA processing	129	2.27e-03	1.56e-01	1.89e-02
HSF1 activation	26	2.33e-03	3.45e-01	1.92e-02
Attenuation phase	23	2.38e-03	3.66e-01	1.95e-02
HCMV Late Events	64	2.41e-03	2.19e-01	1.96e-02
NF-kB is activated and signals survival	12	2.45e-03	5.05e-01	1.98e-02
mRNA Splicing - Minor Pathway	52	2.50e-03	2.42e-01	2.01e-02
Base Excision Repair	54	2.51e-03	2.38e-01	2.01e-02
Senescence-Associated Secretory Phenotype (SASP)	60	2.63e-03	2.25e-01	2.10e-02
Hedgehog ‘on’ state	82	2.70e-03	1.92e-01	2.14e-02
RAF-independent MAPK1/3 activation	21	2.73e-03	3.78e-01	2.15e-02
Metabolism of proteins	1608	2.86e-03	4.53e-02	2.24e-02
Regulation of PTEN gene transcription	58	2.91e-03	2.26e-01	2.27e-02
Signal Transduction	1911	3.01e-03	4.18e-02	2.33e-02
Complex I biogenesis	57	3.18e-03	2.26e-01	2.45e-02
Transport of bile salts and organic acids, metal ions and amine compounds	48	3.22e-03	-2.46e-01	2.46e-02
Regulation of RAS by GAPs	64	3.23e-03	2.13e-01	2.46e-02
tRNA Aminoacylation	42	3.36e-03	2.62e-01	2.55e-02
CLEC7A (Dectin-1) signaling	95	3.53e-03	1.73e-01	2.66e-02
Muscle contraction	150	3.61e-03	1.38e-01	2.71e-02
Post-translational modification: synthesis of GPI-anchored proteins	52	3.65e-03	-2.33e-01	2.73e-02
Activation of HOX genes during differentiation	67	3.76e-03	2.05e-01	2.78e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	67	3.76e-03	2.05e-01	2.78e-02
Regulation of PTEN stability and activity	67	3.83e-03	2.04e-01	2.82e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	4.10e-03	2.08e-01	2.99e-02
Programmed Cell Death	185	4.11e-03	1.23e-01	2.99e-02
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	77	4.23e-03	1.89e-01	3.06e-02
Gene expression (Transcription)	1304	4.49e-03	4.74e-02	3.22e-02
tRNA processing in the mitochondrion	26	4.50e-03	3.22e-01	3.22e-02
Regulation of RUNX2 expression and activity	67	4.86e-03	1.99e-01	3.46e-02
Antigen processing: Ubiquitination & Proteasome degradation	293	4.90e-03	9.58e-02	3.47e-02
FRS-mediated FGFR3 signaling	13	5.38e-03	-4.46e-01	3.79e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	87	5.46e-03	1.72e-01	3.83e-02
Nuclear Events (kinase and transcription factor activation)	55	5.72e-03	2.16e-01	3.99e-02
The citric acid (TCA) cycle and respiratory electron transport	172	5.83e-03	1.22e-01	4.04e-02
p75NTR signals via NF-kB	15	5.84e-03	4.11e-01	4.04e-02
TP53 Regulates Transcription of Death Receptors and Ligands	11	6.25e-03	4.76e-01	4.29e-02
O-linked glycosylation of mucins	36	6.26e-03	-2.63e-01	4.29e-02
Vesicle-mediated transport	613	6.31e-03	-6.50e-02	4.30e-02
Cyclin A/B1/B2 associated events during G2/M transition	21	6.84e-03	-3.41e-01	4.64e-02
Signaling by NOTCH3	45	6.91e-03	2.33e-01	4.67e-02
ISG15 antiviral mechanism	72	7.13e-03	1.83e-01	4.77e-02
Interferon gamma signaling	79	7.14e-03	1.75e-01	4.77e-02
Protein localization	154	7.49e-03	1.25e-01	4.96e-02
Fc epsilon receptor (FCERI) signaling	167	7.50e-03	-1.20e-01	4.96e-02
Synthesis of PE	13	7.53e-03	-4.28e-01	4.96e-02
Cytokine Signaling in Immune system	562	7.64e-03	6.61e-02	5.01e-02
HIV elongation arrest and recovery	32	7.70e-03	2.72e-01	5.01e-02
Pausing and recovery of HIV elongation	32	7.70e-03	2.72e-01	5.01e-02
Cellular response to heat stress	97	7.90e-03	1.56e-01	5.11e-02
Assembly Of The HIV Virion	16	8.21e-03	3.82e-01	5.29e-02
Voltage gated Potassium channels	14	8.30e-03	-4.07e-01	5.32e-02
DNA Repair	275	8.47e-03	9.25e-02	5.40e-02
Regulation of KIT signaling	16	8.49e-03	-3.80e-01	5.40e-02
Resolution of Abasic Sites (AP sites)	37	8.55e-03	2.50e-01	5.40e-02
Gap-filling DNA repair synthesis and ligation in TC-NER	63	8.57e-03	1.92e-01	5.40e-02
Neutrophil degranulation	434	8.79e-03	-7.36e-02	5.49e-02
Glycogen storage diseases	14	8.81e-03	4.04e-01	5.49e-02
Respiratory electron transport	103	8.83e-03	1.49e-01	5.49e-02
Peptide hormone metabolism	55	8.99e-03	-2.04e-01	5.57e-02
MAPK family signaling cascades	269	9.06e-03	9.27e-02	5.58e-02
MAPK1/MAPK3 signaling	233	9.49e-03	9.88e-02	5.82e-02
Membrane binding and targetting of GAG proteins	14	1.04e-02	3.95e-01	6.35e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.04e-02	3.95e-01	6.35e-02
G-protein activation	15	1.05e-02	-3.82e-01	6.36e-02
Synthesis of PA	29	1.05e-02	-2.74e-01	6.36e-02
Mitochondrial translation termination	90	1.06e-02	1.56e-01	6.36e-02
Mitochondrial translation	96	1.08e-02	1.51e-01	6.44e-02
SUMOylation of chromatin organization proteins	57	1.10e-02	1.95e-01	6.55e-02
Activated NTRK2 signals through FRS2 and FRS3	11	1.11e-02	-4.42e-01	6.60e-02
RAF/MAP kinase cascade	228	1.19e-02	9.69e-02	7.03e-02
NR1H2 and NR1H3-mediated signaling	38	1.22e-02	2.35e-01	7.17e-02
Collagen chain trimerization	38	1.23e-02	2.35e-01	7.17e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	125	1.23e-02	1.30e-01	7.17e-02
HCMV Early Events	69	1.24e-02	1.74e-01	7.17e-02
Suppression of phagosomal maturation	13	1.25e-02	4.00e-01	7.21e-02
Signaling by ALK	25	1.26e-02	2.88e-01	7.28e-02
Trafficking and processing of endosomal TLR	10	1.29e-02	-4.54e-01	7.40e-02
Signaling by Hedgehog	127	1.31e-02	1.28e-01	7.51e-02
Mitochondrial translation elongation	90	1.35e-02	1.51e-01	7.67e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus	22	1.36e-02	3.04e-01	7.70e-02
Telomere Maintenance	74	1.38e-02	1.66e-01	7.76e-02
Late endosomal microautophagy	30	1.38e-02	2.60e-01	7.76e-02
Disorders of transmembrane transporters	140	1.42e-02	1.20e-01	7.93e-02
Class I MHC mediated antigen processing & presentation	354	1.42e-02	7.61e-02	7.93e-02
Signaling by SCF-KIT	41	1.43e-02	-2.21e-01	7.93e-02
RNA Polymerase II Transcription	1176	1.47e-02	4.27e-02	8.15e-02
p75NTR recruits signalling complexes	12	1.48e-02	4.06e-01	8.17e-02
Response of Mtb to phagocytosis	23	1.49e-02	2.93e-01	8.17e-02
Signaling by BMP	25	1.56e-02	-2.80e-01	8.52e-02
MET activates PTK2 signaling	16	1.61e-02	3.48e-01	8.75e-02
Phospholipid metabolism	181	1.61e-02	-1.04e-01	8.75e-02
The NLRP3 inflammasome	15	1.63e-02	3.58e-01	8.79e-02
Cyclin E associated events during G1/S transition	79	1.63e-02	1.56e-01	8.79e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	1.70e-02	2.44e-01	9.10e-02
S Phase	149	1.71e-02	1.13e-01	9.15e-02
Transcriptional regulation by RUNX2	109	1.72e-02	1.32e-01	9.16e-02
Degradation of beta-catenin by the destruction complex	82	1.73e-02	1.52e-01	9.20e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	24	1.76e-02	2.80e-01	9.29e-02
CS/DS degradation	11	1.80e-02	-4.12e-01	9.46e-02
Global Genome Nucleotide Excision Repair (GG-NER)	83	1.81e-02	1.50e-01	9.50e-02
Cyclin A:Cdk2-associated events at S phase entry	81	1.82e-02	1.52e-01	9.53e-02
Folding of actin by CCT/TriC	10	1.84e-02	4.31e-01	9.58e-02
Mitochondrial tRNA aminoacylation	21	1.95e-02	2.94e-01	1.01e-01
Keratan sulfate biosynthesis	22	1.96e-02	-2.88e-01	1.01e-01
Mitochondrial translation initiation	90	1.97e-02	1.42e-01	1.02e-01
Generic Transcription Pathway	1058	1.99e-02	4.28e-02	1.02e-01
NRIF signals cell death from the nucleus	15	2.05e-02	3.46e-01	1.05e-01
Chromosome Maintenance	92	2.09e-02	1.39e-01	1.06e-01
ALK mutants bind TKIs	10	2.11e-02	-4.21e-01	1.07e-01
Dual incision in TC-NER	64	2.15e-02	1.66e-01	1.09e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	37	2.17e-02	2.18e-01	1.10e-01
Keratan sulfate degradation	11	2.20e-02	-3.99e-01	1.11e-01
PIP3 activates AKT signaling	238	2.21e-02	8.63e-02	1.11e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.22e-02	2.75e-01	1.11e-01
Regulation of TP53 Activity through Acetylation	29	2.23e-02	2.45e-01	1.11e-01
Peroxisomal protein import	56	2.26e-02	1.76e-01	1.12e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	67	2.29e-02	1.61e-01	1.13e-01
Post-chaperonin tubulin folding pathway	17	2.30e-02	3.18e-01	1.13e-01
TCR signaling	111	2.35e-02	1.25e-01	1.15e-01
SUMO E3 ligases SUMOylate target proteins	154	2.36e-02	1.06e-01	1.15e-01
Laminin interactions	21	2.37e-02	2.85e-01	1.15e-01
Budding and maturation of HIV virion	27	2.38e-02	2.51e-01	1.15e-01
Sema4D induced cell migration and growth-cone collapse	19	2.44e-02	2.98e-01	1.18e-01
Formation of tubulin folding intermediates by CCT/TriC	20	2.46e-02	2.90e-01	1.18e-01
SUMOylation of DNA methylation proteins	16	2.49e-02	3.24e-01	1.19e-01
COPI-mediated anterograde transport	80	2.49e-02	1.45e-01	1.19e-01
Antigen processing-Cross presentation	97	2.53e-02	1.32e-01	1.20e-01
PI-3K cascade:FGFR3	11	2.53e-02	-3.89e-01	1.20e-01
Transcriptional regulation by small RNAs	59	2.60e-02	1.68e-01	1.23e-01
Common Pathway of Fibrin Clot Formation	13	2.64e-02	-3.56e-01	1.24e-01
p75 NTR receptor-mediated signalling	88	2.64e-02	1.37e-01	1.24e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	2.67e-02	2.34e-01	1.24e-01
Citric acid cycle (TCA cycle)	22	2.68e-02	2.73e-01	1.24e-01
Cytosolic iron-sulfur cluster assembly	12	2.70e-02	3.69e-01	1.24e-01
Cytosolic tRNA aminoacylation	24	2.73e-02	2.60e-01	1.24e-01
APC truncation mutants have impaired AXIN binding	14	2.73e-02	-3.41e-01	1.24e-01
AXIN missense mutants destabilize the destruction complex	14	2.73e-02	-3.41e-01	1.24e-01
Signaling by AMER1 mutants	14	2.73e-02	-3.41e-01	1.24e-01
Signaling by APC mutants	14	2.73e-02	-3.41e-01	1.24e-01
Signaling by AXIN mutants	14	2.73e-02	-3.41e-01	1.24e-01
Truncations of AMER1 destabilize the destruction complex	14	2.73e-02	-3.41e-01	1.24e-01
rRNA modification in the nucleus and cytosol	59	2.74e-02	1.66e-01	1.24e-01
Cell junction organization	60	2.77e-02	1.64e-01	1.25e-01
EPH-ephrin mediated repulsion of cells	39	2.80e-02	2.03e-01	1.26e-01
RIP-mediated NFkB activation via ZBP1	17	2.80e-02	3.08e-01	1.26e-01
Formation of RNA Pol II elongation complex	57	2.83e-02	1.68e-01	1.26e-01
RNA Polymerase II Transcription Elongation	57	2.83e-02	1.68e-01	1.26e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	2.86e-02	1.95e-01	1.26e-01
HIV Transcription Elongation	42	2.86e-02	1.95e-01	1.26e-01
Tat-mediated elongation of the HIV-1 transcript	42	2.86e-02	1.95e-01	1.26e-01
Death Receptor Signalling	130	2.90e-02	1.11e-01	1.28e-01
Dual Incision in GG-NER	40	2.90e-02	2.00e-01	1.28e-01
Metal ion SLC transporters	20	3.01e-02	-2.80e-01	1.32e-01
Formation of TC-NER Pre-Incision Complex	53	3.02e-02	1.72e-01	1.32e-01
Positive epigenetic regulation of rRNA expression	57	3.03e-02	1.66e-01	1.32e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	3.06e-02	3.22e-01	1.33e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	3.06e-02	3.22e-01	1.33e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.12e-02	2.40e-01	1.34e-01
Beta-catenin independent WNT signaling	128	3.12e-02	1.10e-01	1.34e-01
G beta:gamma signalling through BTK	12	3.13e-02	-3.59e-01	1.34e-01
Base-Excision Repair, AP Site Formation	27	3.16e-02	2.39e-01	1.35e-01
Transport of Mature Transcript to Cytoplasm	81	3.18e-02	1.38e-01	1.36e-01
Signaling by NTRK1 (TRKA)	105	3.25e-02	1.21e-01	1.38e-01
Infectious disease	733	3.29e-02	4.66e-02	1.39e-01
Pexophagy	11	3.31e-02	3.71e-01	1.40e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	3.33e-02	3.55e-01	1.40e-01
Glycosaminoglycan metabolism	96	3.35e-02	-1.26e-01	1.41e-01
L1CAM interactions	83	3.39e-02	1.35e-01	1.42e-01
SUMOylation	160	3.42e-02	9.72e-02	1.43e-01
Thromboxane signalling through TP receptor	17	3.44e-02	-2.96e-01	1.43e-01
Collagen biosynthesis and modifying enzymes	59	3.44e-02	1.59e-01	1.43e-01
ZBP1(DAI) mediated induction of type I IFNs	20	3.50e-02	2.72e-01	1.45e-01
Gap junction trafficking and regulation	17	3.51e-02	2.95e-01	1.45e-01
Glycerophospholipid biosynthesis	104	3.52e-02	-1.20e-01	1.45e-01
Lysosome Vesicle Biogenesis	30	3.53e-02	2.22e-01	1.45e-01
Inhibition of DNA recombination at telomere	32	3.56e-02	2.15e-01	1.46e-01
Class B/2 (Secretin family receptors)	48	3.57e-02	1.75e-01	1.46e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	30	3.59e-02	2.21e-01	1.46e-01
CTLA4 inhibitory signaling	18	3.64e-02	-2.85e-01	1.46e-01
HIV Life Cycle	144	3.65e-02	1.01e-01	1.46e-01
G1/S Transition	119	3.65e-02	1.11e-01	1.46e-01
G2/M Transition	174	3.65e-02	9.20e-02	1.46e-01
SLC-mediated transmembrane transport	161	3.65e-02	-9.56e-02	1.46e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	13	3.66e-02	-3.35e-01	1.46e-01
Cell death signalling via NRAGE, NRIF and NADE	71	3.67e-02	1.43e-01	1.46e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	3.67e-02	1.86e-01	1.46e-01
Keratan sulfate/keratin metabolism	27	3.68e-02	-2.32e-01	1.46e-01
RNA Polymerase III Transcription Initiation	36	3.72e-02	2.01e-01	1.47e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	3.79e-02	1.83e-01	1.48e-01
RNA Polymerase I Promoter Clearance	61	3.79e-02	1.54e-01	1.48e-01
RNA Polymerase I Transcription	61	3.79e-02	1.54e-01	1.48e-01
Incretin synthesis, secretion, and inactivation	11	3.82e-02	-3.61e-01	1.49e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	11	3.82e-02	-3.61e-01	1.49e-01
Signaling by NOTCH2	30	3.84e-02	2.18e-01	1.49e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	3.87e-02	2.99e-01	1.50e-01
Zinc transporters	13	3.88e-02	-3.31e-01	1.50e-01
Synthesis, secretion, and deacylation of Ghrelin	13	3.91e-02	-3.30e-01	1.51e-01
MHC class II antigen presentation	87	3.93e-02	1.28e-01	1.51e-01
NCAM1 interactions	24	3.94e-02	2.43e-01	1.51e-01
Polo-like kinase mediated events	14	4.02e-02	-3.17e-01	1.54e-01
G2/M Checkpoints	122	4.04e-02	1.08e-01	1.54e-01
Mitotic G2-G2/M phases	176	4.07e-02	8.96e-02	1.55e-01
TRAF6 mediated NF-kB activation	25	4.08e-02	2.36e-01	1.55e-01
Signaling by FGFR3 in disease	15	4.15e-02	-3.04e-01	1.57e-01
Signaling by FGFR3 point mutants in cancer	15	4.15e-02	-3.04e-01	1.57e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	4.18e-02	2.22e-01	1.57e-01
Late Phase of HIV Life Cycle	132	4.18e-02	1.03e-01	1.57e-01
Cellular Senescence	136	4.22e-02	1.01e-01	1.58e-01
NCAM signaling for neurite out-growth	45	4.23e-02	1.75e-01	1.58e-01
Formation of the beta-catenin:TCF transactivating complex	41	4.25e-02	1.83e-01	1.58e-01
RNA Polymerase III Chain Elongation	18	4.34e-02	2.75e-01	1.60e-01
Intracellular signaling by second messengers	274	4.35e-02	7.10e-02	1.60e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	4.36e-02	1.94e-01	1.60e-01
Inflammasomes	19	4.36e-02	2.67e-01	1.60e-01
Neddylation	224	4.37e-02	7.83e-02	1.60e-01
RA biosynthesis pathway	14	4.38e-02	3.11e-01	1.60e-01
Netrin-1 signaling	38	4.41e-02	1.89e-01	1.61e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	24	4.42e-02	2.37e-01	1.61e-01
Viral Messenger RNA Synthesis	44	4.45e-02	1.75e-01	1.62e-01
Glycogen metabolism	26	4.47e-02	2.28e-01	1.62e-01
ER to Golgi Anterograde Transport	128	4.50e-02	1.03e-01	1.63e-01
DNA strand elongation	29	4.52e-02	2.15e-01	1.63e-01
SUMOylation of RNA binding proteins	47	4.53e-02	1.69e-01	1.63e-01
IL-6-type cytokine receptor ligand interactions	13	4.53e-02	-3.21e-01	1.63e-01
Regulation of signaling by CBL	18	4.59e-02	-2.72e-01	1.64e-01
Signaling by Receptor Tyrosine Kinases	441	4.59e-02	5.57e-02	1.64e-01
Gluconeogenesis	28	4.60e-02	2.18e-01	1.64e-01
Regulation of TLR by endogenous ligand	15	4.67e-02	-2.97e-01	1.66e-01
Prefoldin mediated transfer of substrate to CCT/TriC	25	4.68e-02	2.30e-01	1.66e-01
C-type lectin receptors (CLRs)	120	4.71e-02	1.05e-01	1.66e-01
HDACs deacetylate histones	41	4.72e-02	1.79e-01	1.66e-01
RNA Polymerase I Transcription Initiation	46	4.73e-02	1.69e-01	1.67e-01
G-protein beta:gamma signalling	26	4.78e-02	-2.24e-01	1.68e-01
Dectin-2 family	12	4.80e-02	-3.30e-01	1.68e-01
Regulation of HSF1-mediated heat shock response	79	4.81e-02	1.29e-01	1.68e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	4.89e-02	-2.68e-01	1.70e-01
Downstream signaling of activated FGFR3	18	4.94e-02	-2.68e-01	1.72e-01
SHC-mediated cascade:FGFR3	11	5.05e-02	-3.41e-01	1.75e-01
Synthesis of PIPs at the late endosome membrane	11	5.11e-02	-3.40e-01	1.76e-01
Acyl chain remodelling of PG	10	5.11e-02	-3.56e-01	1.76e-01
Amyloid fiber formation	47	5.19e-02	1.64e-01	1.79e-01
Assembly of collagen fibrils and other multimeric structures	49	5.32e-02	1.60e-01	1.83e-01
Association of TriC/CCT with target proteins during biosynthesis	36	5.33e-02	1.86e-01	1.83e-01
G beta:gamma signalling through CDC42	14	5.46e-02	-2.97e-01	1.87e-01
Termination of translesion DNA synthesis	29	5.53e-02	2.06e-01	1.89e-01
Cell-cell junction organization	36	5.61e-02	1.84e-01	1.91e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	29	5.63e-02	-2.05e-01	1.91e-01
Signaling by Nuclear Receptors	211	5.76e-02	7.60e-02	1.95e-01
Defective Intrinsic Pathway for Apoptosis	20	5.77e-02	2.45e-01	1.95e-01
Processing of Intronless Pre-mRNAs	19	5.79e-02	2.51e-01	1.95e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	23	5.87e-02	2.28e-01	1.97e-01
TP53 Regulates Transcription of Cell Death Genes	40	5.88e-02	1.73e-01	1.97e-01
HDMs demethylate histones	21	5.93e-02	2.38e-01	1.97e-01
Cleavage of the damaged pyrimidine	25	5.94e-02	2.18e-01	1.97e-01
Depyrimidination	25	5.94e-02	2.18e-01	1.97e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	25	5.94e-02	2.18e-01	1.97e-01
Sialic acid metabolism	28	5.97e-02	-2.06e-01	1.98e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	27	6.09e-02	2.08e-01	2.01e-01
G beta:gamma signalling through PI3Kgamma	19	6.18e-02	-2.48e-01	2.04e-01
Cell-Cell communication	88	6.36e-02	1.14e-01	2.09e-01
Platelet activation, signaling and aggregation	214	6.43e-02	-7.35e-02	2.11e-01
Rap1 signalling	13	6.43e-02	-2.96e-01	2.11e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	6.46e-02	1.61e-01	2.11e-01
Ub-specific processing proteases	162	6.64e-02	8.37e-02	2.16e-01
Downregulation of ERBB2:ERBB3 signaling	12	6.68e-02	3.06e-01	2.17e-01
Sema4D in semaphorin signaling	23	6.69e-02	2.21e-01	2.17e-01
Cellular hexose transport	13	6.79e-02	2.93e-01	2.20e-01
RAB geranylgeranylation	52	6.81e-02	-1.46e-01	2.20e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	28	6.86e-02	1.99e-01	2.21e-01
Metabolism of lipids	607	6.96e-02	-4.34e-02	2.24e-01
Myogenesis	26	6.99e-02	2.05e-01	2.24e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	28	7.11e-02	1.97e-01	2.25e-01
S33 mutants of beta-catenin aren’t phosphorylated	15	7.14e-02	-2.69e-01	2.25e-01
S37 mutants of beta-catenin aren’t phosphorylated	15	7.14e-02	-2.69e-01	2.25e-01
S45 mutants of beta-catenin aren’t phosphorylated	15	7.14e-02	-2.69e-01	2.25e-01
Signaling by CTNNB1 phospho-site mutants	15	7.14e-02	-2.69e-01	2.25e-01
Signaling by GSK3beta mutants	15	7.14e-02	-2.69e-01	2.25e-01
T41 mutants of beta-catenin aren’t phosphorylated	15	7.14e-02	-2.69e-01	2.25e-01
Ion transport by P-type ATPases	41	7.15e-02	-1.63e-01	2.25e-01
Miscellaneous transport and binding events	21	7.33e-02	-2.26e-01	2.30e-01
Diseases of programmed cell death	50	7.54e-02	1.45e-01	2.37e-01
EPH-Ephrin signaling	80	7.60e-02	1.15e-01	2.38e-01
Establishment of Sister Chromatid Cohesion	10	7.67e-02	-3.23e-01	2.39e-01
Cleavage of the damaged purine	20	7.81e-02	2.28e-01	2.42e-01
Depurination	20	7.81e-02	2.28e-01	2.42e-01
Recognition and association of DNA glycosylase with site containing an affected purine	20	7.81e-02	2.28e-01	2.42e-01
G1/S-Specific Transcription	23	7.91e-02	-2.12e-01	2.45e-01
Thrombin signalling through proteinase activated receptors (PARs)	22	8.05e-02	-2.15e-01	2.49e-01
Advanced glycosylation endproduct receptor signaling	13	8.11e-02	2.79e-01	2.50e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	8.14e-02	2.06e-01	2.50e-01
Potential therapeutics for SARS	79	8.23e-02	1.13e-01	2.53e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	35	8.27e-02	1.70e-01	2.53e-01
Resolution of Sister Chromatid Cohesion	87	8.28e-02	-1.08e-01	2.53e-01
SARS-CoV Infections	145	8.35e-02	8.34e-02	2.55e-01
mRNA 3’-end processing	56	8.38e-02	1.34e-01	2.55e-01
Synthesis of PIPs at the early endosome membrane	16	8.49e-02	-2.49e-01	2.58e-01
Platelet sensitization by LDL	17	8.52e-02	-2.41e-01	2.58e-01
Signaling by Retinoic Acid	34	8.59e-02	1.70e-01	2.59e-01
Potassium Channels	49	8.76e-02	-1.41e-01	2.64e-01
Erythropoietin activates RAS	13	8.77e-02	-2.74e-01	2.64e-01
Translesion Synthesis by POLH	18	8.95e-02	2.31e-01	2.68e-01
MyD88 cascade initiated on plasma membrane	83	8.97e-02	1.08e-01	2.68e-01
Toll Like Receptor 10 (TLR10) Cascade	83	8.97e-02	1.08e-01	2.68e-01
Toll Like Receptor 5 (TLR5) Cascade	83	8.97e-02	1.08e-01	2.68e-01
Acyl chain remodelling of PS	15	9.19e-02	-2.51e-01	2.74e-01
MyD88 dependent cascade initiated on endosome	89	9.23e-02	1.03e-01	2.74e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	89	9.23e-02	1.03e-01	2.74e-01
Interleukin-10 signaling	21	9.25e-02	2.12e-01	2.74e-01
Interaction between L1 and Ankyrins	22	9.30e-02	2.07e-01	2.74e-01
NoRC negatively regulates rRNA expression	57	9.31e-02	1.29e-01	2.74e-01
Epigenetic regulation of gene expression	98	9.34e-02	9.82e-02	2.74e-01
Regulation of insulin secretion	56	9.41e-02	-1.29e-01	2.75e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	9.42e-02	-2.42e-01	2.75e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	9.42e-02	-2.42e-01	2.75e-01
Gene Silencing by RNA	82	9.48e-02	1.07e-01	2.76e-01
Signaling by ALK fusions and activated point mutants	52	9.53e-02	1.34e-01	2.77e-01
Signaling by ALK in cancer	52	9.53e-02	1.34e-01	2.77e-01
Regulation of FZD by ubiquitination	15	9.60e-02	2.48e-01	2.78e-01
Opioid Signalling	75	9.64e-02	-1.11e-01	2.79e-01
TP53 Regulates Transcription of DNA Repair Genes	61	9.77e-02	1.23e-01	2.82e-01
IRE1alpha activates chaperones	50	9.93e-02	1.35e-01	2.86e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	18	1.00e-01	2.24e-01	2.86e-01
Neurodegenerative Diseases	18	1.00e-01	2.24e-01	2.86e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.00e-01	1.12e-01	2.86e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	1.01e-01	1.26e-01	2.86e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	1.01e-01	1.26e-01	2.86e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	1.01e-01	1.26e-01	2.86e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	1.01e-01	1.26e-01	2.86e-01
Signaling by NOTCH1 in Cancer	57	1.01e-01	1.26e-01	2.86e-01
Prostacyclin signalling through prostacyclin receptor	13	1.01e-01	-2.62e-01	2.87e-01
GPVI-mediated activation cascade	29	1.03e-01	-1.75e-01	2.90e-01
Methylation	12	1.03e-01	-2.72e-01	2.90e-01
Formation of Fibrin Clot (Clotting Cascade)	22	1.04e-01	-2.01e-01	2.91e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	1.04e-01	-2.61e-01	2.91e-01
Sensory processing of sound by outer hair cells of the cochlea	34	1.04e-01	1.61e-01	2.91e-01
Activation of the AP-1 family of transcription factors	10	1.04e-01	2.97e-01	2.91e-01
Signaling by WNT	239	1.04e-01	6.11e-02	2.91e-01
FOXO-mediated transcription of cell death genes	15	1.05e-01	2.42e-01	2.92e-01
Collagen formation	78	1.06e-01	1.06e-01	2.93e-01
Adenylate cyclase inhibitory pathway	12	1.06e-01	2.70e-01	2.93e-01
Synthesis of substrates in N-glycan biosythesis	58	1.06e-01	-1.23e-01	2.94e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.07e-01	-2.81e-01	2.95e-01
Signaling by FGFR3 fusions in cancer	10	1.07e-01	-2.94e-01	2.95e-01
FRS-mediated FGFR2 signaling	16	1.08e-01	-2.32e-01	2.97e-01
Regulation of RUNX1 Expression and Activity	18	1.10e-01	-2.18e-01	3.01e-01
Transcriptional Regulation by VENTX	37	1.10e-01	1.52e-01	3.01e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	1.12e-01	1.74e-01	3.06e-01
Mitotic Anaphase	204	1.12e-01	6.46e-02	3.06e-01
VLDLR internalisation and degradation	11	1.12e-01	2.77e-01	3.06e-01
Negative regulation of MAPK pathway	42	1.13e-01	1.41e-01	3.08e-01
GPCR ligand binding	169	1.14e-01	7.06e-02	3.09e-01
Formation of the Early Elongation Complex	33	1.16e-01	1.58e-01	3.14e-01
Formation of the HIV-1 Early Elongation Complex	33	1.16e-01	1.58e-01	3.14e-01
RNA Polymerase I Promoter Escape	42	1.17e-01	1.40e-01	3.15e-01
tRNA processing in the nucleus	58	1.17e-01	1.19e-01	3.15e-01
Platelet homeostasis	69	1.19e-01	-1.09e-01	3.19e-01
Glucose metabolism	82	1.19e-01	9.96e-02	3.20e-01
PCNA-Dependent Long Patch Base Excision Repair	20	1.20e-01	2.01e-01	3.20e-01
B-WICH complex positively regulates rRNA expression	42	1.20e-01	1.39e-01	3.20e-01
G beta:gamma signalling through PLC beta	14	1.20e-01	-2.40e-01	3.20e-01
Diseases associated with glycosaminoglycan metabolism	35	1.20e-01	-1.52e-01	3.20e-01
CD28 co-stimulation	30	1.20e-01	-1.64e-01	3.20e-01
Toll Like Receptor 9 (TLR9) Cascade	93	1.21e-01	9.32e-02	3.20e-01
RHO GTPases activate CIT	18	1.21e-01	2.11e-01	3.20e-01
Infection with Mycobacterium tuberculosis	27	1.21e-01	1.72e-01	3.20e-01
Gap junction trafficking	15	1.22e-01	2.31e-01	3.21e-01
Spry regulation of FGF signaling	16	1.23e-01	2.23e-01	3.22e-01
Cytosolic sulfonation of small molecules	16	1.23e-01	-2.23e-01	3.22e-01
Regulation of PTEN mRNA translation	11	1.23e-01	-2.69e-01	3.22e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	49	1.25e-01	1.27e-01	3.27e-01
Chondroitin sulfate biosynthesis	16	1.26e-01	-2.21e-01	3.27e-01
Synthesis of bile acids and bile salts	26	1.26e-01	1.73e-01	3.27e-01
Negative regulation of FGFR1 signaling	26	1.26e-01	1.73e-01	3.27e-01
Activation of G protein gated Potassium channels	18	1.26e-01	-2.08e-01	3.27e-01
G protein gated Potassium channels	18	1.26e-01	-2.08e-01	3.27e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	1.26e-01	-2.08e-01	3.27e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	26	1.27e-01	1.73e-01	3.27e-01
Negative epigenetic regulation of rRNA expression	60	1.28e-01	1.14e-01	3.29e-01
ADP signalling through P2Y purinoceptor 12	14	1.28e-01	-2.35e-01	3.29e-01
Diseases of signal transduction by growth factor receptors and second messengers	385	1.28e-01	4.53e-02	3.30e-01
RMTs methylate histone arginines	35	1.29e-01	1.48e-01	3.31e-01
Trafficking of GluR2-containing AMPA receptors	11	1.30e-01	2.64e-01	3.31e-01
Homologous DNA Pairing and Strand Exchange	37	1.30e-01	-1.44e-01	3.31e-01
Regulation of BACH1 activity	11	1.30e-01	2.64e-01	3.31e-01
Cyclin D associated events in G1	44	1.30e-01	-1.32e-01	3.31e-01
G1 Phase	44	1.30e-01	-1.32e-01	3.31e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	88	1.31e-01	9.33e-02	3.32e-01
Mitotic Telophase/Cytokinesis	11	1.31e-01	-2.63e-01	3.32e-01
Syndecan interactions	19	1.32e-01	-2.00e-01	3.33e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	47	1.32e-01	1.27e-01	3.33e-01
Signaling by NOTCH1	72	1.33e-01	1.03e-01	3.35e-01
Packaging Of Telomere Ends	17	1.33e-01	2.10e-01	3.35e-01
APC-Cdc20 mediated degradation of Nek2A	24	1.34e-01	1.77e-01	3.35e-01
RAC1 GTPase cycle	174	1.34e-01	-6.60e-02	3.35e-01
Ca2+ pathway	50	1.35e-01	-1.22e-01	3.37e-01
Protein folding	81	1.35e-01	9.61e-02	3.37e-01
RNA Polymerase II Pre-transcription Events	78	1.36e-01	9.78e-02	3.38e-01
Signal transduction by L1	21	1.36e-01	1.88e-01	3.39e-01
APC/C:Cdc20 mediated degradation of Cyclin B	23	1.36e-01	1.79e-01	3.39e-01
Oxidative Stress Induced Senescence	74	1.37e-01	1.00e-01	3.39e-01
RND3 GTPase cycle	36	1.37e-01	-1.43e-01	3.40e-01
Ephrin signaling	17	1.38e-01	2.08e-01	3.42e-01
Deubiquitination	231	1.39e-01	5.67e-02	3.42e-01
DNA Double Strand Break Response	48	1.39e-01	1.24e-01	3.42e-01
FRS-mediated FGFR4 signaling	14	1.39e-01	-2.28e-01	3.42e-01
Synthesis of PIPs at the plasma membrane	51	1.39e-01	-1.20e-01	3.42e-01
RHO GTPases activate PKNs	42	1.40e-01	1.32e-01	3.42e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	21	1.41e-01	1.86e-01	3.45e-01
Recognition of DNA damage by PCNA-containing replication complex	28	1.41e-01	1.61e-01	3.45e-01
Mitotic Metaphase and Anaphase	205	1.42e-01	5.97e-02	3.45e-01
XBP1(S) activates chaperone genes	48	1.45e-01	1.22e-01	3.52e-01
Negative regulation of the PI3K/AKT network	87	1.45e-01	-9.04e-02	3.52e-01
Platelet Adhesion to exposed collagen	10	1.45e-01	-2.66e-01	3.53e-01
RET signaling	32	1.47e-01	-1.48e-01	3.56e-01
Export of Viral Ribonucleoproteins from Nucleus	33	1.47e-01	1.46e-01	3.56e-01
Transcriptional regulation of granulopoiesis	40	1.48e-01	1.32e-01	3.56e-01
Regulation of IFNA signaling	12	1.48e-01	2.41e-01	3.56e-01
Nucleotide catabolism	29	1.48e-01	-1.55e-01	3.57e-01
RHO GTPases Activate ROCKs	19	1.50e-01	1.91e-01	3.60e-01
Presynaptic phase of homologous DNA pairing and strand exchange	35	1.51e-01	-1.40e-01	3.61e-01
Extension of Telomeres	48	1.51e-01	1.20e-01	3.61e-01
Chemokine receptors bind chemokines	22	1.52e-01	1.76e-01	3.61e-01
Estrogen-dependent gene expression	96	1.52e-01	8.46e-02	3.61e-01
RNA Polymerase II Transcription Termination	65	1.53e-01	1.03e-01	3.61e-01
Semaphorin interactions	60	1.53e-01	1.07e-01	3.61e-01
Toll Like Receptor 3 (TLR3) Cascade	92	1.53e-01	8.63e-02	3.61e-01
Deposition of new CENPA-containing nucleosomes at the centromere	30	1.53e-01	1.51e-01	3.61e-01
Nucleosome assembly	30	1.53e-01	1.51e-01	3.61e-01
Beta-catenin phosphorylation cascade	17	1.53e-01	-2.00e-01	3.61e-01
FLT3 Signaling	37	1.54e-01	-1.36e-01	3.61e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	50	1.54e-01	-1.17e-01	3.61e-01
Signaling by Non-Receptor Tyrosine Kinases	49	1.54e-01	1.18e-01	3.61e-01
Signaling by PTK6	49	1.54e-01	1.18e-01	3.61e-01
EGFR downregulation	25	1.55e-01	1.64e-01	3.62e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	72	1.57e-01	-9.66e-02	3.66e-01
RNA Polymerase III Abortive And Retractive Initiation	41	1.57e-01	1.28e-01	3.66e-01
RNA Polymerase III Transcription	41	1.57e-01	1.28e-01	3.66e-01
Signaling by PDGF	50	1.57e-01	1.16e-01	3.66e-01
Insulin processing	21	1.61e-01	-1.77e-01	3.73e-01
N-Glycan antennae elongation	12	1.62e-01	-2.33e-01	3.76e-01
RNA Polymerase I Promoter Opening	15	1.64e-01	2.08e-01	3.79e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	12	1.64e-01	2.32e-01	3.79e-01
Transport of vitamins, nucleosides, and related molecules	30	1.65e-01	-1.47e-01	3.79e-01
Intraflagellar transport	38	1.65e-01	-1.30e-01	3.79e-01
Signaling by ERBB4	48	1.66e-01	1.16e-01	3.81e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	1.68e-01	1.41e-01	3.86e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	1.69e-01	-2.51e-01	3.87e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.69e-01	-1.93e-01	3.87e-01
DNA Damage Bypass	43	1.70e-01	1.21e-01	3.87e-01
Transport to the Golgi and subsequent modification	152	1.71e-01	6.45e-02	3.89e-01
Bile acid and bile salt metabolism	29	1.72e-01	1.46e-01	3.92e-01
Signaling by NTRKs	122	1.74e-01	7.14e-02	3.95e-01
Depolymerisation of the Nuclear Lamina	14	1.75e-01	-2.10e-01	3.96e-01
Separation of Sister Chromatids	151	1.77e-01	6.38e-02	4.00e-01
Mitotic Prometaphase	166	1.77e-01	-6.08e-02	4.01e-01
Cell Cycle Checkpoints	223	1.78e-01	5.24e-02	4.02e-01
Diseases of carbohydrate metabolism	29	1.79e-01	1.44e-01	4.04e-01
Protein ubiquitination	70	1.79e-01	9.29e-02	4.04e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	51	1.83e-01	1.08e-01	4.10e-01
Glutathione synthesis and recycling	11	1.83e-01	2.32e-01	4.10e-01
PIWI-interacting RNA (piRNA) biogenesis	20	1.84e-01	1.72e-01	4.10e-01
Activation of BH3-only proteins	27	1.84e-01	1.48e-01	4.10e-01
Keratinization	19	1.84e-01	1.76e-01	4.10e-01
Glycogen synthesis	15	1.84e-01	1.98e-01	4.10e-01
Adaptive Immune System	666	1.85e-01	-3.03e-02	4.10e-01
Immune System	1613	1.85e-01	-2.01e-02	4.10e-01
DNA Double-Strand Break Repair	126	1.85e-01	6.85e-02	4.10e-01
SUMOylation of DNA damage response and repair proteins	74	1.87e-01	8.88e-02	4.14e-01
Unfolded Protein Response (UPR)	88	1.87e-01	8.14e-02	4.14e-01
PI Metabolism	78	1.88e-01	-8.63e-02	4.15e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.89e-01	-1.84e-01	4.16e-01
STING mediated induction of host immune responses	14	1.90e-01	2.03e-01	4.16e-01
PKA activation	16	1.90e-01	1.89e-01	4.16e-01
Nuclear import of Rev protein	34	1.90e-01	1.30e-01	4.16e-01
RND1 GTPase cycle	34	1.90e-01	-1.30e-01	4.16e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	1.91e-01	1.38e-01	4.16e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	1.91e-01	1.38e-01	4.16e-01
E3 ubiquitin ligases ubiquitinate target proteins	50	1.92e-01	1.07e-01	4.18e-01
Mitochondrial Fatty Acid Beta-Oxidation	33	1.94e-01	1.31e-01	4.23e-01
Processing of Capped Intronless Pre-mRNA	28	1.95e-01	1.42e-01	4.24e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	2.01e-01	-2.33e-01	4.37e-01
Glutamate and glutamine metabolism	11	2.03e-01	-2.22e-01	4.39e-01
Regulation of TNFR1 signaling	34	2.03e-01	1.26e-01	4.39e-01
RHOU GTPase cycle	39	2.03e-01	1.18e-01	4.39e-01
Glycolysis	65	2.05e-01	9.10e-02	4.42e-01
Other semaphorin interactions	17	2.06e-01	1.77e-01	4.44e-01
Aggrephagy	21	2.06e-01	1.59e-01	4.44e-01
Mitochondrial protein import	64	2.07e-01	9.14e-02	4.44e-01
ADP signalling through P2Y purinoceptor 1	18	2.08e-01	-1.72e-01	4.45e-01
EML4 and NUDC in mitotic spindle formation	79	2.09e-01	-8.19e-02	4.47e-01
Nuclear signaling by ERBB4	27	2.09e-01	1.40e-01	4.47e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	17	2.10e-01	1.76e-01	4.47e-01
Integration of energy metabolism	84	2.10e-01	-7.92e-02	4.47e-01
Transcriptional Regulation by TP53	339	2.10e-01	3.97e-02	4.47e-01
TICAM1-dependent activation of IRF3/IRF7	11	2.11e-01	2.18e-01	4.48e-01
PI3K events in ERBB2 signaling	13	2.11e-01	2.00e-01	4.48e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	11	2.12e-01	2.18e-01	4.48e-01
Plasma lipoprotein clearance	27	2.12e-01	1.39e-01	4.48e-01
Glycosphingolipid metabolism	37	2.13e-01	-1.18e-01	4.48e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	21	2.13e-01	1.57e-01	4.48e-01
Trafficking of AMPA receptors	21	2.13e-01	1.57e-01	4.48e-01
Rab regulation of trafficking	117	2.13e-01	-6.67e-02	4.48e-01
Vpr-mediated nuclear import of PICs	34	2.14e-01	1.23e-01	4.49e-01
Interleukin-6 signaling	11	2.14e-01	2.16e-01	4.49e-01
PKA activation in glucagon signalling	15	2.17e-01	1.84e-01	4.55e-01
Transport of the SLBP independent Mature mRNA	35	2.18e-01	1.20e-01	4.56e-01
Biotin transport and metabolism	11	2.18e-01	2.14e-01	4.56e-01
Adherens junctions interactions	20	2.19e-01	1.59e-01	4.56e-01
MyD88-independent TLR4 cascade	96	2.19e-01	7.26e-02	4.56e-01
TRIF(TICAM1)-mediated TLR4 signaling	96	2.19e-01	7.26e-02	4.56e-01
Transport of the SLBP Dependant Mature mRNA	36	2.20e-01	1.18e-01	4.56e-01
MAP kinase activation	63	2.21e-01	8.93e-02	4.57e-01
Interleukin-2 signaling	10	2.21e-01	2.24e-01	4.57e-01
TP53 Regulates Transcription of Cell Cycle Genes	42	2.23e-01	1.09e-01	4.60e-01
Signaling by WNT in cancer	29	2.24e-01	-1.30e-01	4.62e-01
RHOH GTPase cycle	33	2.24e-01	-1.22e-01	4.62e-01
O-linked glycosylation	79	2.25e-01	-7.89e-02	4.63e-01
tRNA modification in the nucleus and cytosol	43	2.26e-01	1.07e-01	4.63e-01
FOXO-mediated transcription of cell cycle genes	16	2.27e-01	1.74e-01	4.66e-01
Tight junction interactions	15	2.29e-01	1.79e-01	4.68e-01
Metalloprotease DUBs	19	2.29e-01	1.59e-01	4.68e-01
Cilium Assembly	174	2.29e-01	-5.29e-02	4.68e-01
CASP8 activity is inhibited	10	2.30e-01	2.19e-01	4.68e-01
Dimerization of procaspase-8	10	2.30e-01	2.19e-01	4.68e-01
Regulation by c-FLIP	10	2.30e-01	2.19e-01	4.68e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.31e-01	1.55e-01	4.68e-01
Response to elevated platelet cytosolic Ca2+	113	2.31e-01	-6.53e-02	4.68e-01
Nuclear Envelope (NE) Reassembly	66	2.32e-01	8.51e-02	4.70e-01
Platelet degranulation	109	2.32e-01	-6.63e-02	4.70e-01
Recycling pathway of L1	25	2.33e-01	1.38e-01	4.70e-01
Response of EIF2AK1 (HRI) to heme deficiency	15	2.35e-01	1.77e-01	4.74e-01
Peroxisomal lipid metabolism	25	2.35e-01	1.37e-01	4.74e-01
RHOD GTPase cycle	50	2.36e-01	-9.69e-02	4.75e-01
PKMTs methylate histone lysines	43	2.37e-01	1.04e-01	4.75e-01
ERBB2 Regulates Cell Motility	12	2.37e-01	1.97e-01	4.75e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	80	2.38e-01	-7.64e-02	4.76e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	17	2.38e-01	1.65e-01	4.76e-01
Retrograde neurotrophin signalling	12	2.39e-01	1.96e-01	4.77e-01
Intra-Golgi traffic	40	2.40e-01	1.07e-01	4.78e-01
Interleukin-17 signaling	67	2.40e-01	8.30e-02	4.78e-01
Acyl chain remodelling of PC	19	2.41e-01	-1.56e-01	4.78e-01
PRC2 methylates histones and DNA	25	2.42e-01	1.35e-01	4.80e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	2.42e-01	1.20e-01	4.80e-01
G0 and Early G1	22	2.43e-01	-1.44e-01	4.80e-01
Protein methylation	15	2.43e-01	1.74e-01	4.80e-01
Telomere C-strand (Lagging Strand) Synthesis	33	2.43e-01	1.17e-01	4.80e-01
Cohesin Loading onto Chromatin	10	2.48e-01	-2.11e-01	4.88e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	97	2.50e-01	6.77e-02	4.89e-01
Toll Like Receptor 2 (TLR2) Cascade	97	2.50e-01	6.77e-02	4.89e-01
Toll Like Receptor TLR1:TLR2 Cascade	97	2.50e-01	6.77e-02	4.89e-01
Toll Like Receptor TLR6:TLR2 Cascade	97	2.50e-01	6.77e-02	4.89e-01
Growth hormone receptor signaling	19	2.50e-01	1.52e-01	4.89e-01
Peptide ligand-binding receptors	63	2.50e-01	8.38e-02	4.89e-01
SUMOylation of transcription cofactors	44	2.51e-01	1.00e-01	4.89e-01
CD28 dependent PI3K/Akt signaling	19	2.51e-01	-1.52e-01	4.89e-01
G alpha (z) signalling events	35	2.51e-01	1.12e-01	4.89e-01
Sphingolipid metabolism	75	2.52e-01	-7.66e-02	4.89e-01
Listeria monocytogenes entry into host cells	17	2.52e-01	1.60e-01	4.89e-01
Nucleotide salvage	22	2.52e-01	1.41e-01	4.89e-01
Deactivation of the beta-catenin transactivating complex	38	2.53e-01	1.07e-01	4.91e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	17	2.54e-01	1.60e-01	4.91e-01
Disorders of Developmental Biology	12	2.56e-01	1.89e-01	4.93e-01
Disorders of Nervous System Development	12	2.56e-01	1.89e-01	4.93e-01
Loss of function of MECP2 in Rett syndrome	12	2.56e-01	1.89e-01	4.93e-01
Pervasive developmental disorders	12	2.56e-01	1.89e-01	4.93e-01
STAT3 nuclear events downstream of ALK signaling	10	2.57e-01	2.07e-01	4.94e-01
Intrinsic Pathway for Apoptosis	50	2.57e-01	9.26e-02	4.94e-01
Signaling by EGFR in Cancer	21	2.59e-01	1.42e-01	4.95e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	14	2.59e-01	1.74e-01	4.95e-01
Signaling by NTRK3 (TRKC)	16	2.60e-01	1.63e-01	4.96e-01
RAB GEFs exchange GTP for GDP on RABs	85	2.60e-01	-7.07e-02	4.96e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	2.60e-01	-2.06e-01	4.96e-01
IRAK2 mediated activation of TAK1 complex	10	2.61e-01	2.05e-01	4.96e-01
RUNX2 regulates bone development	28	2.62e-01	1.22e-01	4.98e-01
Mitochondrial biogenesis	90	2.63e-01	6.83e-02	4.99e-01
Josephin domain DUBs	10	2.64e-01	2.04e-01	4.99e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	15	2.64e-01	1.67e-01	4.99e-01
MET promotes cell motility	26	2.64e-01	1.27e-01	4.99e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	14	2.66e-01	1.72e-01	5.02e-01
Post-translational protein phosphorylation	76	2.69e-01	7.33e-02	5.07e-01
Meiotic synapsis	36	2.73e-01	1.06e-01	5.12e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	10	2.73e-01	-2.00e-01	5.12e-01
Cholesterol biosynthesis	25	2.73e-01	-1.27e-01	5.12e-01
PD-1 signaling	20	2.74e-01	1.41e-01	5.12e-01
Synthesis of IP3 and IP4 in the cytosol	22	2.74e-01	1.35e-01	5.12e-01
Integrin signaling	23	2.75e-01	-1.31e-01	5.15e-01
SARS-CoV-1 Infection	47	2.76e-01	9.18e-02	5.16e-01
The role of Nef in HIV-1 replication and disease pathogenesis	24	2.77e-01	1.28e-01	5.17e-01
Signal amplification	24	2.79e-01	-1.28e-01	5.19e-01
Homology Directed Repair	97	2.81e-01	6.34e-02	5.22e-01
Cristae formation	31	2.81e-01	1.12e-01	5.22e-01
Tryptophan catabolism	10	2.81e-01	-1.97e-01	5.22e-01
Regulated proteolysis of p75NTR	11	2.83e-01	1.87e-01	5.24e-01
Purine catabolism	15	2.84e-01	-1.60e-01	5.25e-01
RNA Polymerase III Transcription Termination	23	2.85e-01	1.29e-01	5.25e-01
FOXO-mediated transcription	56	2.85e-01	8.26e-02	5.25e-01
Interleukin-7 signaling	19	2.86e-01	1.42e-01	5.25e-01
Termination of O-glycan biosynthesis	13	2.86e-01	-1.71e-01	5.25e-01
M Phase	333	2.86e-01	3.41e-02	5.25e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	2.87e-01	1.41e-01	5.25e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	2.87e-01	1.41e-01	5.25e-01
Presynaptic function of Kainate receptors	15	2.87e-01	-1.59e-01	5.25e-01
SUMOylation of immune response proteins	10	2.87e-01	1.94e-01	5.25e-01
Interleukin receptor SHC signaling	20	2.89e-01	1.37e-01	5.28e-01
RHO GTPases Activate WASPs and WAVEs	36	2.90e-01	-1.02e-01	5.29e-01
Ovarian tumor domain proteases	36	2.91e-01	1.02e-01	5.29e-01
Long-term potentiation	15	2.91e-01	1.58e-01	5.29e-01
Translation of Structural Proteins	29	2.91e-01	1.13e-01	5.29e-01
Nicotinate metabolism	27	2.92e-01	-1.17e-01	5.29e-01
Fanconi Anemia Pathway	33	2.93e-01	1.06e-01	5.30e-01
Translation of Replicase and Assembly of the Replication Transcription Complex	12	2.93e-01	1.75e-01	5.30e-01
Interactions of Rev with host cellular proteins	37	2.94e-01	9.98e-02	5.30e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	2.96e-01	1.82e-01	5.33e-01
alpha-linolenic acid (ALA) metabolism	11	2.96e-01	1.82e-01	5.33e-01
Chaperone Mediated Autophagy	18	2.97e-01	1.42e-01	5.33e-01
Costimulation by the CD28 family	60	2.98e-01	-7.78e-02	5.33e-01
IRAK4 deficiency (TLR2/4)	15	2.98e-01	-1.55e-01	5.33e-01
NRAGE signals death through JNK	54	2.98e-01	8.19e-02	5.33e-01
RHOB GTPase cycle	61	2.99e-01	7.69e-02	5.33e-01
Purine salvage	13	2.99e-01	1.66e-01	5.33e-01
Mitotic G1 phase and G1/S transition	136	3.00e-01	5.15e-02	5.33e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	3.00e-01	-1.73e-01	5.33e-01
Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function	19	3.01e-01	-1.37e-01	5.33e-01
Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function	19	3.01e-01	-1.37e-01	5.33e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	19	3.01e-01	-1.37e-01	5.33e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	19	3.01e-01	-1.37e-01	5.33e-01
Diseases of DNA Double-Strand Break Repair	19	3.01e-01	-1.37e-01	5.33e-01
Downstream signaling of activated FGFR2	21	3.02e-01	-1.30e-01	5.35e-01
Blood group systems biosynthesis	13	3.03e-01	-1.65e-01	5.36e-01
Telomere C-strand synthesis initiation	13	3.07e-01	1.64e-01	5.42e-01
PI-3K cascade:FGFR2	14	3.08e-01	-1.57e-01	5.44e-01
Hyaluronan uptake and degradation	10	3.11e-01	-1.85e-01	5.48e-01
Postmitotic nuclear pore complex (NPC) reformation	27	3.12e-01	1.13e-01	5.48e-01
Transcriptional activation of mitochondrial biogenesis	51	3.12e-01	8.19e-02	5.48e-01
Metabolism	1731	3.15e-01	1.48e-02	5.53e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	75	3.17e-01	-6.69e-02	5.53e-01
Amplification of signal from the kinetochores	75	3.17e-01	-6.69e-02	5.53e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	33	3.17e-01	-1.01e-01	5.53e-01
Signaling by KIT in disease	20	3.17e-01	-1.29e-01	5.53e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	3.17e-01	-1.29e-01	5.53e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	84	3.18e-01	6.31e-02	5.53e-01
Metabolism of non-coding RNA	53	3.18e-01	7.93e-02	5.53e-01
snRNP Assembly	53	3.18e-01	7.93e-02	5.53e-01
Toll-like Receptor Cascades	142	3.19e-01	-4.85e-02	5.54e-01
Amine ligand-binding receptors	10	3.19e-01	1.82e-01	5.54e-01
Regulation of TP53 Activity through Association with Co-factors	11	3.20e-01	1.73e-01	5.54e-01
Interleukin-15 signaling	14	3.23e-01	1.53e-01	5.57e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	3.23e-01	-1.48e-01	5.57e-01
Signaling by GPCR	361	3.25e-01	3.03e-02	5.60e-01
Regulation of TP53 Activity through Phosphorylation	85	3.25e-01	-6.18e-02	5.60e-01
Signaling by NTRK2 (TRKB)	24	3.27e-01	-1.16e-01	5.62e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	3.28e-01	1.79e-01	5.64e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	17	3.29e-01	1.37e-01	5.65e-01
CRMPs in Sema3A signaling	15	3.30e-01	-1.45e-01	5.65e-01
MicroRNA (miRNA) biogenesis	24	3.31e-01	1.15e-01	5.67e-01
WNT5A-dependent internalization of FZD4	14	3.32e-01	1.50e-01	5.68e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	3.33e-01	1.77e-01	5.70e-01
Interleukin-12 family signaling	44	3.35e-01	-8.41e-02	5.71e-01
E2F mediated regulation of DNA replication	20	3.36e-01	-1.24e-01	5.72e-01
Activation of kainate receptors upon glutamate binding	22	3.36e-01	-1.19e-01	5.72e-01
Factors involved in megakaryocyte development and platelet production	100	3.36e-01	-5.57e-02	5.72e-01
Uptake and actions of bacterial toxins	22	3.37e-01	1.18e-01	5.73e-01
Rev-mediated nuclear export of HIV RNA	35	3.39e-01	9.34e-02	5.75e-01
Amino acid transport across the plasma membrane	23	3.39e-01	-1.15e-01	5.75e-01
Metabolic disorders of biological oxidation enzymes	23	3.40e-01	1.15e-01	5.75e-01
Glutathione conjugation	29	3.41e-01	1.02e-01	5.76e-01
Dissolution of Fibrin Clot	11	3.42e-01	-1.66e-01	5.76e-01
IRS-mediated signalling	36	3.43e-01	-9.13e-02	5.78e-01
DNA methylation	16	3.43e-01	1.37e-01	5.78e-01
Inactivation of CSF3 (G-CSF) signaling	25	3.44e-01	1.09e-01	5.78e-01
Triglyceride metabolism	25	3.44e-01	-1.09e-01	5.78e-01
Interactions of Vpr with host cellular proteins	37	3.46e-01	8.96e-02	5.79e-01
eNOS activation	11	3.46e-01	-1.64e-01	5.79e-01
Negative regulation of FGFR4 signaling	23	3.47e-01	1.13e-01	5.79e-01
Fatty acid metabolism	137	3.47e-01	4.66e-02	5.79e-01
Downregulation of ERBB2 signaling	26	3.47e-01	1.07e-01	5.79e-01
Metabolism of fat-soluble vitamins	32	3.47e-01	9.60e-02	5.79e-01
RHO GTPases activate PAKs	21	3.49e-01	1.18e-01	5.81e-01
Activation of AMPK downstream of NMDARs	10	3.50e-01	-1.71e-01	5.82e-01
Elastic fibre formation	35	3.51e-01	-9.12e-02	5.83e-01
NS1 Mediated Effects on Host Pathways	40	3.52e-01	8.52e-02	5.84e-01
PKA-mediated phosphorylation of CREB	18	3.53e-01	1.26e-01	5.86e-01
RIPK1-mediated regulated necrosis	28	3.54e-01	1.01e-01	5.86e-01
Regulation of necroptotic cell death	28	3.54e-01	1.01e-01	5.86e-01
Neurotransmitter release cycle	34	3.55e-01	-9.17e-02	5.87e-01
Arachidonic acid metabolism	35	3.57e-01	-9.01e-02	5.89e-01
Plasma lipoprotein assembly, remodeling, and clearance	49	3.57e-01	7.61e-02	5.89e-01
Autophagy	125	3.58e-01	4.76e-02	5.90e-01
G alpha (s) signalling events	72	3.59e-01	-6.26e-02	5.90e-01
SUMOylation of SUMOylation proteins	35	3.60e-01	8.94e-02	5.91e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	3.63e-01	1.17e-01	5.96e-01
RUNX3 regulates NOTCH signaling	14	3.64e-01	1.40e-01	5.96e-01
Regulation of TP53 Expression and Degradation	34	3.65e-01	-8.97e-02	5.98e-01
Chaperonin-mediated protein folding	75	3.66e-01	6.04e-02	5.98e-01
Defective pyroptosis	25	3.66e-01	1.04e-01	5.98e-01
Signaling by Erythropoietin	24	3.67e-01	-1.06e-01	5.98e-01
Regulation of localization of FOXO transcription factors	11	3.69e-01	-1.57e-01	6.00e-01
NOTCH3 Intracellular Domain Regulates Transcription	21	3.69e-01	1.13e-01	6.00e-01
Cargo concentration in the ER	27	3.70e-01	-9.98e-02	6.00e-01
Transcriptional Regulation by MECP2	45	3.70e-01	7.73e-02	6.00e-01
Constitutive Signaling by Overexpressed ERBB2	11	3.71e-01	-1.56e-01	6.02e-01
Nuclear events stimulated by ALK signaling in cancer	17	3.74e-01	1.25e-01	6.06e-01
Phase II - Conjugation of compounds	62	3.75e-01	-6.52e-02	6.07e-01
Formation of Incision Complex in GG-NER	43	3.76e-01	7.81e-02	6.07e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	14	3.77e-01	-1.36e-01	6.09e-01
Disease	1372	3.77e-01	1.44e-02	6.09e-01
Metabolism of Angiotensinogen to Angiotensins	12	3.78e-01	-1.47e-01	6.09e-01
Downstream signaling of activated FGFR4	19	3.79e-01	-1.17e-01	6.10e-01
Regulation of TP53 Degradation	33	3.80e-01	-8.84e-02	6.10e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	3.81e-01	1.53e-01	6.11e-01
Extra-nuclear estrogen signaling	60	3.81e-01	-6.54e-02	6.11e-01
Glycogen breakdown (glycogenolysis)	15	3.82e-01	1.30e-01	6.11e-01
RNA Polymerase I Transcription Termination	29	3.82e-01	9.38e-02	6.11e-01
RHOV GTPase cycle	34	3.83e-01	8.64e-02	6.13e-01
RAC3 GTPase cycle	85	3.84e-01	-5.47e-02	6.13e-01
Intrinsic Pathway of Fibrin Clot Formation	12	3.86e-01	1.44e-01	6.14e-01
Activation of the pre-replicative complex	26	3.86e-01	9.82e-02	6.14e-01
Signaling by EGFR	43	3.86e-01	7.64e-02	6.14e-01
G2/M DNA damage checkpoint	59	3.87e-01	-6.52e-02	6.14e-01
Interleukin-12 signaling	38	3.87e-01	-8.12e-02	6.14e-01
NOTCH1 Intracellular Domain Regulates Transcription	47	3.87e-01	7.29e-02	6.14e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	165	3.88e-01	3.90e-02	6.14e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	3.88e-01	-1.21e-01	6.14e-01
Hyaluronan metabolism	14	3.92e-01	-1.32e-01	6.19e-01
Caspase activation via extrinsic apoptotic signalling pathway	23	3.93e-01	1.03e-01	6.20e-01
Diseases associated with N-glycosylation of proteins	17	3.93e-01	1.20e-01	6.20e-01
Telomere Extension By Telomerase	21	3.96e-01	1.07e-01	6.23e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	50	3.96e-01	6.94e-02	6.23e-01
Translesion synthesis by REV1	16	3.98e-01	1.22e-01	6.25e-01
Signaling by MET	60	3.99e-01	6.30e-02	6.25e-01
Condensation of Prometaphase Chromosomes	10	3.99e-01	-1.54e-01	6.25e-01
PI-3K cascade:FGFR4	12	4.00e-01	-1.40e-01	6.26e-01
Interconversion of nucleotide di- and triphosphates	26	4.02e-01	-9.50e-02	6.28e-01
G alpha (q) signalling events	107	4.02e-01	-4.69e-02	6.28e-01
G alpha (i) signalling events	157	4.04e-01	3.87e-02	6.29e-01
RHO GTPases Activate Formins	101	4.04e-01	-4.81e-02	6.29e-01
Negative regulation of MET activity	19	4.05e-01	1.10e-01	6.30e-01
Retinoid metabolism and transport	29	4.05e-01	8.93e-02	6.30e-01
Interleukin-35 Signalling	10	4.06e-01	-1.52e-01	6.30e-01
MECP2 regulates neuronal receptors and channels	11	4.06e-01	1.45e-01	6.30e-01
Regulated Necrosis	50	4.07e-01	6.79e-02	6.30e-01
Insulin receptor recycling	21	4.07e-01	1.05e-01	6.30e-01
Golgi-to-ER retrograde transport	100	4.08e-01	4.80e-02	6.30e-01
Adrenaline,noradrenaline inhibits insulin secretion	21	4.08e-01	-1.04e-01	6.30e-01
COPI-independent Golgi-to-ER retrograde traffic	33	4.08e-01	8.32e-02	6.30e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	4.10e-01	-1.32e-01	6.32e-01
SUMOylation of ubiquitinylation proteins	39	4.12e-01	7.59e-02	6.35e-01
Activation of Matrix Metalloproteinases	19	4.14e-01	-1.08e-01	6.37e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	4.14e-01	1.31e-01	6.37e-01
RAS processing	17	4.15e-01	1.14e-01	6.37e-01
Processive synthesis on the C-strand of the telomere	18	4.15e-01	1.11e-01	6.37e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	10	4.17e-01	-1.48e-01	6.39e-01
Endogenous sterols	20	4.17e-01	-1.05e-01	6.39e-01
Interleukin-20 family signaling	16	4.18e-01	1.17e-01	6.39e-01
Synthesis of very long-chain fatty acyl-CoAs	18	4.19e-01	-1.10e-01	6.39e-01
Golgi Associated Vesicle Biogenesis	53	4.20e-01	-6.41e-02	6.40e-01
Glyoxylate metabolism and glycine degradation	24	4.20e-01	9.51e-02	6.40e-01
IRS-related events triggered by IGF1R	39	4.22e-01	-7.43e-02	6.42e-01
MyD88 deficiency (TLR2/4)	14	4.23e-01	-1.24e-01	6.44e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	4.24e-01	-8.89e-02	6.44e-01
Signaling by PDGFR in disease	20	4.25e-01	-1.03e-01	6.44e-01
Processing and activation of SUMO	10	4.26e-01	-1.46e-01	6.44e-01
Metabolism of steroid hormones	21	4.26e-01	-1.00e-01	6.44e-01
Signaling by Interleukins	357	4.27e-01	2.45e-02	6.46e-01
Amino acids regulate mTORC1	49	4.31e-01	6.51e-02	6.50e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	4.31e-01	-1.17e-01	6.50e-01
Centrosome maturation	78	4.32e-01	5.15e-02	6.50e-01
Recruitment of mitotic centrosome proteins and complexes	78	4.32e-01	5.15e-02	6.50e-01
Dopamine Neurotransmitter Release Cycle	17	4.33e-01	-1.10e-01	6.51e-01
Transcription of the HIV genome	67	4.35e-01	5.52e-02	6.54e-01
Signaling by Activin	14	4.36e-01	1.20e-01	6.54e-01
Insulin receptor signalling cascade	41	4.37e-01	-7.02e-02	6.55e-01
IRF3-mediated induction of type I IFN	12	4.38e-01	1.29e-01	6.56e-01
IRAK1 recruits IKK complex	10	4.39e-01	-1.41e-01	6.56e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	4.39e-01	-1.41e-01	6.56e-01
Branched-chain amino acid catabolism	21	4.41e-01	-9.73e-02	6.58e-01
SHC-mediated cascade:FGFR2	14	4.41e-01	-1.19e-01	6.58e-01
Translesion synthesis by POLK	17	4.42e-01	1.08e-01	6.58e-01
DAP12 signaling	27	4.43e-01	-8.54e-02	6.59e-01
MTOR signalling	41	4.43e-01	-6.92e-02	6.59e-01
p130Cas linkage to MAPK signaling for integrins	12	4.44e-01	-1.28e-01	6.59e-01
FGFR2 mutant receptor activation	24	4.44e-01	9.02e-02	6.59e-01
Nuclear Receptor transcription pathway	43	4.45e-01	6.73e-02	6.60e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	12	4.46e-01	1.27e-01	6.60e-01
Defective EXT2 causes exostoses 2	12	4.46e-01	1.27e-01	6.60e-01
Signaling by FGFR2	61	4.52e-01	5.57e-02	6.66e-01
Degradation of the extracellular matrix	77	4.52e-01	4.96e-02	6.66e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	13	4.52e-01	-1.21e-01	6.66e-01
Interleukin-2 family signaling	33	4.53e-01	7.56e-02	6.67e-01
Signaling by ERBB2 TMD/JMD mutants	19	4.54e-01	9.93e-02	6.68e-01
FGFR2 alternative splicing	24	4.55e-01	8.82e-02	6.68e-01
Translesion synthesis by POLI	17	4.55e-01	1.05e-01	6.68e-01
SLBP independent Processing of Histone Pre-mRNAs	10	4.55e-01	-1.36e-01	6.68e-01
Cell-extracellular matrix interactions	16	4.57e-01	1.07e-01	6.69e-01
Polymerase switching on the C-strand of the telomere	26	4.57e-01	8.43e-02	6.69e-01
Energy dependent regulation of mTOR by LKB1-AMPK	29	4.61e-01	-7.92e-02	6.73e-01
ABC transporters in lipid homeostasis	12	4.61e-01	1.23e-01	6.74e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	4.62e-01	-1.28e-01	6.75e-01
Signaling by FGFR	71	4.64e-01	5.03e-02	6.77e-01
RUNX2 regulates osteoblast differentiation	22	4.66e-01	8.98e-02	6.78e-01
Early Phase of HIV Life Cycle	13	4.67e-01	1.17e-01	6.79e-01
RHOA GTPase cycle	136	4.67e-01	3.61e-02	6.79e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	24	4.68e-01	-8.57e-02	6.79e-01
Negative regulation of FGFR2 signaling	25	4.69e-01	8.37e-02	6.80e-01
Transcriptional regulation of white adipocyte differentiation	81	4.71e-01	4.63e-02	6.83e-01
Chondroitin sulfate/dermatan sulfate metabolism	42	4.73e-01	-6.40e-02	6.84e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	21	4.73e-01	-9.04e-02	6.84e-01
Notch-HLH transcription pathway	28	4.75e-01	7.81e-02	6.85e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	4.75e-01	1.19e-01	6.85e-01
Cell Cycle	566	4.76e-01	1.76e-02	6.86e-01
Lagging Strand Synthesis	20	4.79e-01	9.14e-02	6.90e-01
Defective B3GAT3 causes JDSSDHD	16	4.80e-01	-1.02e-01	6.90e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	16	4.80e-01	1.02e-01	6.90e-01
Visual phototransduction	54	4.82e-01	5.54e-02	6.91e-01
Inwardly rectifying K+ channels	23	4.83e-01	-8.44e-02	6.92e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	23	4.83e-01	-8.44e-02	6.92e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	12	4.84e-01	1.17e-01	6.93e-01
Processive synthesis on the lagging strand	15	4.85e-01	1.04e-01	6.93e-01
Signaling by Hippo	19	4.85e-01	9.25e-02	6.93e-01
Defects in cobalamin (B12) metabolism	12	4.87e-01	-1.16e-01	6.95e-01
Nuclear Pore Complex (NPC) Disassembly	35	4.88e-01	6.78e-02	6.96e-01
TNF signaling	43	4.89e-01	6.10e-02	6.96e-01
HDR through Single Strand Annealing (SSA)	34	4.89e-01	-6.85e-02	6.96e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	4.91e-01	-1.20e-01	6.98e-01
Signaling by FGFR2 IIIa TM	18	4.92e-01	9.37e-02	6.98e-01
SUMOylation of DNA replication proteins	44	4.93e-01	5.98e-02	6.98e-01
Recruitment of NuMA to mitotic centrosomes	77	4.93e-01	4.52e-02	6.98e-01
mTORC1-mediated signalling	24	4.94e-01	-8.07e-02	6.98e-01
Activation of NMDA receptors and postsynaptic events	58	4.94e-01	-5.20e-02	6.98e-01
Cytochrome P450 - arranged by substrate type	32	4.94e-01	-6.98e-02	6.98e-01
Vasopressin regulates renal water homeostasis via Aquaporins	33	4.95e-01	-6.87e-02	6.98e-01
The phototransduction cascade	18	4.95e-01	9.29e-02	6.98e-01
TP53 Regulates Metabolic Genes	84	4.99e-01	-4.27e-02	7.03e-01
Synthesis of PIPs at the Golgi membrane	15	5.01e-01	1.00e-01	7.04e-01
Selective autophagy	59	5.01e-01	5.06e-02	7.05e-01
Metabolism of vitamins and cofactors	155	5.04e-01	3.11e-02	7.07e-01
MET activates RAP1 and RAC1	11	5.05e-01	-1.16e-01	7.08e-01
Mitochondrial calcium ion transport	22	5.05e-01	8.21e-02	7.08e-01
Mitochondrial iron-sulfur cluster biogenesis	13	5.06e-01	-1.07e-01	7.09e-01
Signaling by CSF3 (G-CSF)	30	5.07e-01	7.00e-02	7.09e-01
N-glycan antennae elongation in the medial/trans-Golgi	19	5.07e-01	-8.79e-02	7.09e-01
SARS-CoV-2 Infection	67	5.08e-01	4.68e-02	7.09e-01
TNFs bind their physiological receptors	14	5.09e-01	1.02e-01	7.09e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	5.09e-01	6.86e-02	7.09e-01
Fatty acyl-CoA biosynthesis	30	5.11e-01	6.94e-02	7.11e-01
Phase 0 - rapid depolarisation	25	5.12e-01	7.57e-02	7.12e-01
Translocation of ZAP-70 to Immunological synapse	16	5.13e-01	9.45e-02	7.12e-01
Assembly of the ORC complex at the origin of replication	20	5.13e-01	8.45e-02	7.12e-01
Formation of ATP by chemiosmotic coupling	18	5.15e-01	8.87e-02	7.13e-01
Signaling by Leptin	11	5.16e-01	-1.13e-01	7.14e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	32	5.17e-01	-6.63e-02	7.14e-01
Scavenging by Class A Receptors	16	5.17e-01	-9.36e-02	7.14e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	37	5.19e-01	-6.13e-02	7.17e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	5.20e-01	8.52e-02	7.17e-01
RHO GTPase Effectors	221	5.21e-01	-2.51e-02	7.17e-01
Signaling by FGFR1	42	5.23e-01	5.70e-02	7.20e-01
Signaling by ERBB2 KD Mutants	22	5.24e-01	7.86e-02	7.20e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	5.26e-01	1.06e-01	7.22e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	5.26e-01	9.16e-02	7.22e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	13	5.28e-01	-1.01e-01	7.22e-01
CaM pathway	31	5.28e-01	-6.55e-02	7.22e-01
Calmodulin induced events	31	5.28e-01	-6.55e-02	7.22e-01
Pre-NOTCH Transcription and Translation	44	5.29e-01	5.49e-02	7.22e-01
Post-translational protein modification	1166	5.29e-01	1.11e-02	7.22e-01
DARPP-32 events	22	5.29e-01	-7.75e-02	7.22e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	92	5.30e-01	3.79e-02	7.22e-01
IGF1R signaling cascade	40	5.30e-01	-5.74e-02	7.22e-01
PECAM1 interactions	12	5.30e-01	-1.05e-01	7.22e-01
Caspase activation via Death Receptors in the presence of ligand	15	5.31e-01	9.34e-02	7.22e-01
Pentose phosphate pathway	13	5.33e-01	-9.98e-02	7.24e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	5.37e-01	6.86e-02	7.29e-01
PLC beta mediated events	44	5.38e-01	-5.37e-02	7.29e-01
Collagen degradation	28	5.40e-01	-6.69e-02	7.31e-01
HS-GAG degradation	17	5.41e-01	8.56e-02	7.32e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	5.42e-01	1.06e-01	7.32e-01
Downstream signal transduction	28	5.43e-01	6.65e-02	7.33e-01
Phosphorylation of the APC/C	19	5.43e-01	8.06e-02	7.33e-01
ATF4 activates genes in response to endoplasmic reticulum stress	25	5.44e-01	7.01e-02	7.33e-01
Cell Cycle, Mitotic	460	5.45e-01	1.65e-02	7.34e-01
Constitutive Signaling by Aberrant PI3K in Cancer	54	5.46e-01	-4.75e-02	7.35e-01
DNA Damage/Telomere Stress Induced Senescence	38	5.48e-01	5.64e-02	7.36e-01
Sensory Perception	120	5.50e-01	3.17e-02	7.38e-01
VEGFR2 mediated vascular permeability	27	5.51e-01	6.63e-02	7.38e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	5.52e-01	6.62e-02	7.38e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	5.52e-01	6.62e-02	7.38e-01
DCC mediated attractive signaling	13	5.52e-01	-9.52e-02	7.39e-01
Phase 2 - plateau phase	11	5.53e-01	1.03e-01	7.39e-01
RHO GTPases Activate NADPH Oxidases	20	5.54e-01	-7.64e-02	7.39e-01
Nicotinamide salvaging	15	5.54e-01	-8.82e-02	7.39e-01
Nucleotide-like (purinergic) receptors	11	5.55e-01	-1.03e-01	7.39e-01
RHOJ GTPase cycle	51	5.56e-01	-4.77e-02	7.40e-01
GABA receptor activation	35	5.57e-01	-5.73e-02	7.41e-01
Initiation of Nuclear Envelope (NE) Reformation	18	5.57e-01	-7.99e-02	7.41e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	5.58e-01	9.38e-02	7.41e-01
Defective B4GALT7 causes EDS, progeroid type	16	5.59e-01	-8.43e-02	7.42e-01
PI3K Cascade	32	5.60e-01	-5.95e-02	7.42e-01
Aflatoxin activation and detoxification	10	5.61e-01	1.06e-01	7.43e-01
Vitamin B5 (pantothenate) metabolism	15	5.63e-01	8.63e-02	7.44e-01
Signaling by FGFR4	33	5.63e-01	5.82e-02	7.44e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	5.64e-01	-8.32e-02	7.45e-01
SHC-mediated cascade:FGFR4	12	5.66e-01	-9.56e-02	7.47e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	20	5.69e-01	7.36e-02	7.49e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	20	5.69e-01	7.36e-02	7.49e-01
SUMOylation of transcription factors	15	5.70e-01	-8.47e-02	7.49e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	13	5.70e-01	9.09e-02	7.49e-01
Mucopolysaccharidoses	11	5.71e-01	-9.86e-02	7.49e-01
AKT phosphorylates targets in the cytosol	14	5.71e-01	8.74e-02	7.49e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	12	5.72e-01	9.42e-02	7.49e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	5.73e-01	8.41e-02	7.49e-01
Formation of the cornified envelope	14	5.73e-01	8.70e-02	7.49e-01
RAC2 GTPase cycle	84	5.74e-01	-3.55e-02	7.50e-01
FGFR2 ligand binding and activation	10	5.79e-01	-1.01e-01	7.56e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	41	5.80e-01	-4.99e-02	7.57e-01
ROS and RNS production in phagocytes	31	5.81e-01	5.72e-02	7.57e-01
Ion channel transport	118	5.82e-01	-2.93e-02	7.58e-01
Removal of the Flap Intermediate from the C-strand	17	5.84e-01	7.67e-02	7.60e-01
Assembly and cell surface presentation of NMDA receptors	18	5.86e-01	-7.41e-02	7.61e-01
Iron uptake and transport	53	5.87e-01	4.32e-02	7.61e-01
Heme biosynthesis	12	5.87e-01	-9.05e-02	7.61e-01
Macroautophagy	111	5.90e-01	2.97e-02	7.64e-01
Nucleotide biosynthesis	12	5.91e-01	8.97e-02	7.65e-01
Transport of small molecules	519	5.93e-01	-1.38e-02	7.65e-01
EPHA-mediated growth cone collapse	15	5.93e-01	7.98e-02	7.65e-01
Gap junction degradation	10	5.93e-01	9.76e-02	7.65e-01
Signaling by cytosolic FGFR1 fusion mutants	18	5.93e-01	7.27e-02	7.65e-01
ERKs are inactivated	13	5.96e-01	8.50e-02	7.68e-01
Anchoring of the basal body to the plasma membrane	94	5.98e-01	-3.15e-02	7.70e-01
Acetylcholine Neurotransmitter Release Cycle	10	5.98e-01	9.62e-02	7.70e-01
Sema3A PAK dependent Axon repulsion	16	6.01e-01	-7.56e-02	7.71e-01
Signaling by TGFB family members	98	6.01e-01	-3.06e-02	7.71e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	6.02e-01	5.51e-02	7.72e-01
Signaling by FLT3 ITD and TKD mutants	15	6.04e-01	-7.73e-02	7.74e-01
Activation of RAC1	12	6.05e-01	8.62e-02	7.74e-01
Glucagon signaling in metabolic regulation	25	6.05e-01	-5.97e-02	7.74e-01
Cytochrome c-mediated apoptotic response	13	6.06e-01	8.27e-02	7.74e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	72	6.06e-01	-3.52e-02	7.74e-01
Interleukin-6 family signaling	20	6.08e-01	-6.63e-02	7.75e-01
TRAF3-dependent IRF activation pathway	13	6.11e-01	8.15e-02	7.79e-01
G-protein mediated events	48	6.14e-01	-4.21e-02	7.81e-01
Alpha-protein kinase 1 signaling pathway	11	6.15e-01	8.76e-02	7.81e-01
EPHB-mediated forward signaling	32	6.15e-01	-5.14e-02	7.81e-01
Condensation of Prophase Chromosomes	24	6.15e-01	-5.93e-02	7.81e-01
Diseases of glycosylation	121	6.15e-01	-2.65e-02	7.81e-01
Transcriptional Regulation by E2F6	33	6.25e-01	-4.92e-02	7.92e-01
Ca-dependent events	33	6.26e-01	-4.90e-02	7.93e-01
Lysine catabolism	10	6.27e-01	-8.88e-02	7.93e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.28e-01	-8.45e-02	7.93e-01
Negative regulation of FLT3	14	6.30e-01	-7.44e-02	7.96e-01
Activation of gene expression by SREBF (SREBP)	42	6.30e-01	4.29e-02	7.96e-01
GPCR downstream signalling	322	6.33e-01	1.55e-02	7.98e-01
Carnitine metabolism	12	6.35e-01	-7.91e-02	8.00e-01
Endosomal/Vacuolar pathway	10	6.36e-01	8.64e-02	8.00e-01
Circadian Clock	64	6.36e-01	-3.42e-02	8.00e-01
SHC-mediated cascade:FGFR1	14	6.39e-01	7.24e-02	8.03e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	6.42e-01	6.15e-02	8.06e-01
Degradation of cysteine and homocysteine	13	6.43e-01	7.44e-02	8.06e-01
Activation of SMO	16	6.43e-01	6.69e-02	8.06e-01
Platelet Aggregation (Plug Formation)	29	6.46e-01	-4.94e-02	8.08e-01
Apoptotic factor-mediated response	19	6.46e-01	6.09e-02	8.08e-01
InlB-mediated entry of Listeria monocytogenes into host cell	13	6.48e-01	7.32e-02	8.09e-01
Regulation of lipid metabolism by PPARalpha	109	6.48e-01	2.53e-02	8.09e-01
ERK/MAPK targets	22	6.49e-01	5.61e-02	8.09e-01
Asparagine N-linked glycosylation	263	6.49e-01	1.63e-02	8.09e-01
COPII-mediated vesicle transport	62	6.50e-01	3.33e-02	8.10e-01
Mitotic Spindle Checkpoint	92	6.52e-01	-2.72e-02	8.11e-01
Phase I - Functionalization of compounds	65	6.52e-01	3.23e-02	8.11e-01
Cargo trafficking to the periciliary membrane	44	6.54e-01	-3.91e-02	8.11e-01
FRS-mediated FGFR1 signaling	16	6.54e-01	-6.48e-02	8.11e-01
Mismatch Repair	14	6.55e-01	6.90e-02	8.12e-01
Metabolism of nucleotides	86	6.56e-01	-2.78e-02	8.12e-01
Signaling by FGFR in disease	54	6.56e-01	3.50e-02	8.12e-01
Signaling by Rho GTPases	571	6.57e-01	1.09e-02	8.12e-01
O-glycosylation of TSR domain-containing proteins	34	6.58e-01	4.39e-02	8.13e-01
Norepinephrine Neurotransmitter Release Cycle	13	6.58e-01	7.09e-02	8.13e-01
Integrin cell surface interactions	57	6.61e-01	-3.36e-02	8.16e-01
Neuronal System	231	6.63e-01	-1.67e-02	8.16e-01
G alpha (12/13) signalling events	68	6.63e-01	-3.06e-02	8.16e-01
SUMOylation of intracellular receptors	26	6.64e-01	4.93e-02	8.16e-01
ER Quality Control Compartment (ERQC)	21	6.64e-01	-5.48e-02	8.16e-01
Interleukin-37 signaling	20	6.66e-01	-5.58e-02	8.17e-01
COPI-dependent Golgi-to-ER retrograde traffic	67	6.68e-01	3.04e-02	8.19e-01
Other interleukin signaling	22	6.68e-01	-5.29e-02	8.19e-01
Gastrin-CREB signalling pathway via PKC and MAPK	15	6.72e-01	-6.32e-02	8.23e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32	6.74e-01	4.30e-02	8.23e-01
Formation of apoptosome	11	6.74e-01	7.32e-02	8.23e-01
Regulation of the apoptosome activity	11	6.74e-01	7.32e-02	8.23e-01
PI3K/AKT Signaling in Cancer	81	6.75e-01	-2.70e-02	8.24e-01
HS-GAG biosynthesis	21	6.77e-01	5.24e-02	8.26e-01
Acyl chain remodelling of PI	10	6.78e-01	-7.58e-02	8.26e-01
Clathrin-mediated endocytosis	123	6.79e-01	-2.17e-02	8.26e-01
Post NMDA receptor activation events	50	6.79e-01	-3.39e-02	8.26e-01
mRNA Capping	29	6.80e-01	4.42e-02	8.27e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.81e-01	7.15e-02	8.27e-01
Signaling by ERBB2 in Cancer	23	6.83e-01	4.92e-02	8.29e-01
Diseases associated with the TLR signaling cascade	27	6.84e-01	-4.52e-02	8.29e-01
Diseases of Immune System	27	6.84e-01	-4.52e-02	8.29e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	6.85e-01	7.06e-02	8.29e-01
TRAF6 mediated IRF7 activation	15	6.86e-01	6.02e-02	8.30e-01
Removal of the Flap Intermediate	14	6.87e-01	6.21e-02	8.31e-01
Signaling by NODAL	15	6.89e-01	-5.97e-02	8.31e-01
Deadenylation of mRNA	22	6.91e-01	4.90e-02	8.33e-01
Ion homeostasis	45	6.94e-01	-3.39e-02	8.36e-01
Diseases of metabolism	196	6.95e-01	1.63e-02	8.37e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	6.97e-01	-7.11e-02	8.39e-01
LDL clearance	17	6.98e-01	5.43e-02	8.39e-01
Regulation of IFNG signaling	13	7.02e-01	-6.12e-02	8.43e-01
HDR through Homologous Recombination (HRR)	59	7.04e-01	2.86e-02	8.44e-01
Sphingolipid de novo biosynthesis	38	7.05e-01	-3.55e-02	8.45e-01
WNT ligand biogenesis and trafficking	15	7.06e-01	-5.63e-02	8.45e-01
Defective B3GALTL causes PpS	33	7.06e-01	3.80e-02	8.45e-01
RHOBTB1 GTPase cycle	23	7.10e-01	-4.48e-02	8.48e-01
Transferrin endocytosis and recycling	27	7.10e-01	-4.13e-02	8.48e-01
Signaling by FGFR4 in disease	11	7.16e-01	-6.33e-02	8.55e-01
FGFR1 mutant receptor activation	25	7.17e-01	4.18e-02	8.56e-01
Pyruvate metabolism	27	7.19e-01	-4.00e-02	8.56e-01
DAG and IP3 signaling	37	7.19e-01	-3.42e-02	8.56e-01
Apoptotic execution phase	43	7.20e-01	-3.16e-02	8.57e-01
activated TAK1 mediates p38 MAPK activation	19	7.21e-01	-4.73e-02	8.57e-01
Processing of SMDT1	15	7.22e-01	5.31e-02	8.57e-01
Frs2-mediated activation	11	7.23e-01	6.18e-02	8.58e-01
Transcription of E2F targets under negative control by DREAM complex	17	7.24e-01	-4.95e-02	8.58e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	7.25e-01	5.63e-02	8.58e-01
ECM proteoglycans	43	7.25e-01	-3.10e-02	8.58e-01
Mitophagy	28	7.26e-01	3.83e-02	8.59e-01
Inactivation, recovery and regulation of the phototransduction cascade	17	7.27e-01	4.89e-02	8.59e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	7.28e-01	6.35e-02	8.60e-01
NOD1/2 Signaling Pathway	32	7.29e-01	-3.54e-02	8.60e-01
Synthesis of PC	23	7.30e-01	-4.15e-02	8.61e-01
Sensory processing of sound	49	7.32e-01	2.83e-02	8.61e-01
Nuclear Envelope Breakdown	52	7.32e-01	-2.75e-02	8.61e-01
MET receptor recycling	10	7.33e-01	-6.23e-02	8.61e-01
Cell recruitment (pro-inflammatory response)	22	7.33e-01	4.20e-02	8.61e-01
Purinergic signaling in leishmaniasis infection	22	7.33e-01	4.20e-02	8.61e-01
Mitotic Prophase	93	7.36e-01	-2.03e-02	8.63e-01
BBSome-mediated cargo-targeting to cilium	20	7.37e-01	-4.34e-02	8.64e-01
Diseases associated with O-glycosylation of proteins	52	7.39e-01	2.67e-02	8.65e-01
RHOBTB GTPase Cycle	35	7.40e-01	-3.24e-02	8.66e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	7.41e-01	5.51e-02	8.66e-01
RND2 GTPase cycle	36	7.47e-01	3.10e-02	8.72e-01
Organelle biogenesis and maintenance	264	7.48e-01	-1.15e-02	8.72e-01
GAB1 signalosome	13	7.48e-01	5.15e-02	8.72e-01
Receptor-type tyrosine-protein phosphatases	11	7.49e-01	5.56e-02	8.73e-01
Detoxification of Reactive Oxygen Species	33	7.50e-01	-3.20e-02	8.73e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	12	7.51e-01	-5.30e-02	8.73e-01
Signaling by RAF1 mutants	35	7.51e-01	-3.10e-02	8.73e-01
Aquaporin-mediated transport	35	7.51e-01	-3.10e-02	8.73e-01
Class A/1 (Rhodopsin-like receptors)	117	7.52e-01	1.69e-02	8.73e-01
Cargo recognition for clathrin-mediated endocytosis	86	7.53e-01	-1.96e-02	8.73e-01
trans-Golgi Network Vesicle Budding	67	7.56e-01	2.19e-02	8.76e-01
Carboxyterminal post-translational modifications of tubulin	28	7.59e-01	3.35e-02	8.78e-01
Triglyceride catabolism	17	7.59e-01	-4.30e-02	8.78e-01
Heme signaling	44	7.60e-01	-2.66e-02	8.78e-01
RAF activation	34	7.61e-01	-3.02e-02	8.78e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	39	7.65e-01	2.77e-02	8.80e-01
Signaling by RAS mutants	39	7.65e-01	2.77e-02	8.80e-01
Signaling by moderate kinase activity BRAF mutants	39	7.65e-01	2.77e-02	8.80e-01
Signaling downstream of RAS mutants	39	7.65e-01	2.77e-02	8.80e-01
Signalling to ERKs	32	7.72e-01	-2.96e-02	8.87e-01
TBC/RABGAPs	44	7.74e-01	-2.51e-02	8.87e-01
Signaling by PDGFRA extracellular domain mutants	12	7.74e-01	-4.79e-02	8.87e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	7.74e-01	-4.79e-02	8.87e-01
Meiosis	55	7.75e-01	2.23e-02	8.87e-01
RHOQ GTPase cycle	55	7.76e-01	-2.22e-02	8.87e-01
Regulation of PLK1 Activity at G2/M Transition	84	7.76e-01	1.80e-02	8.87e-01
Diseases of mitotic cell cycle	37	7.77e-01	-2.70e-02	8.87e-01
Plasma lipoprotein assembly	11	7.77e-01	4.94e-02	8.87e-01
Sensory perception of taste	14	7.77e-01	4.37e-02	8.87e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	7.79e-01	3.18e-02	8.89e-01
Diseases associated with glycosylation precursor biosynthesis	18	7.80e-01	-3.80e-02	8.89e-01
Metabolism of cofactors	18	7.80e-01	3.80e-02	8.89e-01
Stimuli-sensing channels	59	7.81e-01	2.09e-02	8.89e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	35	7.82e-01	-2.71e-02	8.89e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	587	7.82e-01	6.71e-03	8.89e-01
Biosynthesis of specialized proresolving mediators (SPMs)	12	7.85e-01	-4.56e-02	8.90e-01
Erythrocytes take up carbon dioxide and release oxygen	12	7.85e-01	-4.54e-02	8.90e-01
O2/CO2 exchange in erythrocytes	12	7.85e-01	-4.54e-02	8.90e-01
Plasma lipoprotein remodeling	17	7.86e-01	3.80e-02	8.90e-01
Oncogene Induced Senescence	32	7.86e-01	2.77e-02	8.90e-01
ESR-mediated signaling	153	7.89e-01	1.25e-02	8.91e-01
Kinesins	28	7.90e-01	-2.91e-02	8.91e-01
Signaling by FGFR1 in disease	32	7.90e-01	-2.71e-02	8.91e-01
PPARA activates gene expression	107	7.91e-01	1.49e-02	8.91e-01
Processing of DNA double-strand break ends	63	7.91e-01	-1.93e-02	8.91e-01
Deadenylation-dependent mRNA decay	53	7.91e-01	-2.10e-02	8.91e-01
Metabolism of nitric oxide: NOS3 activation and regulation	15	7.94e-01	-3.90e-02	8.93e-01
RHOBTB2 GTPase cycle	23	7.94e-01	-3.14e-02	8.93e-01
Biosynthesis of DHA-derived SPMs	10	7.98e-01	-4.67e-02	8.97e-01
Pregnenolone biosynthesis	10	7.99e-01	4.65e-02	8.97e-01
Metabolism of water-soluble vitamins and cofactors	106	8.02e-01	1.41e-02	8.99e-01
Pre-NOTCH Processing in Golgi	18	8.03e-01	-3.40e-02	8.99e-01
GABA synthesis, release, reuptake and degradation	10	8.03e-01	-4.56e-02	8.99e-01
SHC1 events in EGFR signaling	10	8.04e-01	4.53e-02	9.00e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	8.10e-01	1.87e-02	9.06e-01
Metabolism of carbohydrates	243	8.12e-01	8.86e-03	9.07e-01
RORA activates gene expression	18	8.13e-01	3.22e-02	9.07e-01
Transmission across Chemical Synapses	164	8.13e-01	-1.07e-02	9.07e-01
Nitric oxide stimulates guanylate cyclase	18	8.19e-01	3.12e-02	9.13e-01
IKK complex recruitment mediated by RIP1	23	8.21e-01	-2.73e-02	9.14e-01
Glutamate Neurotransmitter Release Cycle	19	8.25e-01	-2.93e-02	9.18e-01
PI-3K cascade:FGFR1	14	8.26e-01	3.40e-02	9.18e-01
MET activates RAS signaling	11	8.31e-01	3.72e-02	9.23e-01
Golgi Cisternae Pericentriolar Stack Reorganization	13	8.31e-01	-3.41e-02	9.23e-01
Signaling by FGFR3	32	8.35e-01	-2.13e-02	9.26e-01
Neurexins and neuroligins	33	8.36e-01	2.08e-02	9.26e-01
Neurotransmitter receptors and postsynaptic signal transmission	121	8.37e-01	1.09e-02	9.26e-01
Pyroptosis	22	8.38e-01	2.53e-02	9.26e-01
Phosphorylation of CD3 and TCR zeta chains	19	8.38e-01	2.71e-02	9.26e-01
Regulation of TP53 Activity through Methylation	19	8.38e-01	2.70e-02	9.26e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	28	8.39e-01	2.21e-02	9.27e-01
Molecules associated with elastic fibres	26	8.43e-01	2.24e-02	9.30e-01
TNFR1-induced proapoptotic signaling	12	8.43e-01	3.29e-02	9.30e-01
Extracellular matrix organization	233	8.45e-01	7.47e-03	9.30e-01
Sensory processing of sound by inner hair cells of the cochlea	45	8.48e-01	-1.66e-02	9.33e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	46	8.50e-01	-1.61e-02	9.35e-01
GRB2 events in ERBB2 signaling	13	8.51e-01	3.02e-02	9.35e-01
Repression of WNT target genes	13	8.53e-01	-2.96e-02	9.36e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	8.53e-01	-2.67e-02	9.36e-01
RNA polymerase II transcribes snRNA genes	71	8.54e-01	1.27e-02	9.36e-01
VxPx cargo-targeting to cilium	17	8.55e-01	2.55e-02	9.37e-01
Non-integrin membrane-ECM interactions	37	8.59e-01	-1.69e-02	9.41e-01
Serotonin Neurotransmitter Release Cycle	12	8.60e-01	2.94e-02	9.41e-01
VEGFA-VEGFR2 Pathway	92	8.62e-01	-1.05e-02	9.41e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	30	8.65e-01	-1.80e-02	9.41e-01
Signaling by FGFR2 in disease	34	8.65e-01	1.69e-02	9.41e-01
ADORA2B mediated anti-inflammatory cytokines production	61	8.65e-01	1.26e-02	9.41e-01
Metabolism of steroids	119	8.65e-01	9.00e-03	9.41e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	8.66e-01	-2.24e-02	9.41e-01
Signaling by VEGF	101	8.66e-01	9.74e-03	9.41e-01
Assembly of active LPL and LIPC lipase complexes	11	8.66e-01	-2.93e-02	9.41e-01
CDC42 GTPase cycle	146	8.67e-01	8.06e-03	9.41e-01
Oncogenic MAPK signaling	73	8.68e-01	1.13e-02	9.42e-01
SLC transporter disorders	70	8.70e-01	-1.13e-02	9.44e-01
Activation of GABAB receptors	30	8.72e-01	-1.70e-02	9.45e-01
GABA B receptor activation	30	8.72e-01	-1.70e-02	9.45e-01
Membrane Trafficking	541	8.75e-01	3.98e-03	9.47e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	26	8.76e-01	-1.77e-02	9.47e-01
A tetrasaccharide linker sequence is required for GAG synthesis	21	8.77e-01	-1.95e-02	9.47e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	8.80e-01	-2.05e-02	9.50e-01
RHO GTPase cycle	410	8.81e-01	4.33e-03	9.50e-01
Receptor Mediated Mitophagy	11	8.83e-01	-2.55e-02	9.52e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	8.84e-01	1.89e-02	9.52e-01
Negative regulators of DDX58/IFIH1 signaling	34	8.86e-01	1.43e-02	9.53e-01
Regulation of FOXO transcriptional activity by acetylation	10	8.86e-01	2.61e-02	9.53e-01
RHOF GTPase cycle	38	8.89e-01	-1.31e-02	9.55e-01
RHOG GTPase cycle	70	8.90e-01	9.59e-03	9.55e-01
SIRT1 negatively regulates rRNA expression	19	8.90e-01	1.84e-02	9.55e-01
Leading Strand Synthesis	14	8.93e-01	2.08e-02	9.56e-01
Polymerase switching	14	8.93e-01	2.08e-02	9.56e-01
Defects in vitamin and cofactor metabolism	20	8.96e-01	-1.69e-02	9.56e-01
VEGFR2 mediated cell proliferation	18	8.97e-01	1.77e-02	9.56e-01
Signaling by TGF-beta Receptor Complex	73	8.99e-01	-8.61e-03	9.56e-01
Resolution of D-Loop Structures	27	8.99e-01	1.41e-02	9.56e-01
Signal regulatory protein family interactions	11	9.00e-01	2.19e-02	9.56e-01
PERK regulates gene expression	30	9.00e-01	1.32e-02	9.56e-01
Nonhomologous End-Joining (NHEJ)	39	9.00e-01	-1.16e-02	9.56e-01
Meiotic recombination	31	9.02e-01	1.28e-02	9.56e-01
HIV Transcription Initiation	45	9.03e-01	1.06e-02	9.56e-01
RNA Polymerase II HIV Promoter Escape	45	9.03e-01	1.06e-02	9.56e-01
RNA Polymerase II Promoter Escape	45	9.03e-01	1.06e-02	9.56e-01
RNA Polymerase II Transcription Initiation	45	9.03e-01	1.06e-02	9.56e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	9.03e-01	1.06e-02	9.56e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	9.03e-01	1.06e-02	9.56e-01
cGMP effects	14	9.03e-01	-1.89e-02	9.56e-01
RHOC GTPase cycle	67	9.04e-01	8.50e-03	9.56e-01
Downstream signaling of activated FGFR1	23	9.04e-01	-1.45e-02	9.56e-01
CD209 (DC-SIGN) signaling	20	9.05e-01	1.55e-02	9.56e-01
SHC1 events in ERBB4 signaling	11	9.05e-01	-2.07e-02	9.56e-01
Calnexin/calreticulin cycle	26	9.10e-01	1.28e-02	9.60e-01
Signaling by high-kinase activity BRAF mutants	30	9.10e-01	-1.19e-02	9.60e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	9.11e-01	1.35e-02	9.60e-01
Regulation of MECP2 expression and activity	28	9.12e-01	1.21e-02	9.60e-01
Retrograde transport at the Trans-Golgi-Network	49	9.18e-01	8.49e-03	9.65e-01
Aspartate and asparagine metabolism	10	9.18e-01	1.88e-02	9.65e-01
Nephrin family interactions	18	9.18e-01	1.39e-02	9.65e-01
Inositol phosphate metabolism	41	9.20e-01	-9.08e-03	9.66e-01
Signaling by FLT3 fusion proteins	19	9.21e-01	-1.32e-02	9.66e-01
Interleukin-4 and Interleukin-13 signaling	81	9.21e-01	6.34e-03	9.66e-01
Prolactin receptor signaling	10	9.24e-01	1.75e-02	9.68e-01
Class I peroxisomal membrane protein import	19	9.26e-01	1.23e-02	9.69e-01
Synaptic adhesion-like molecules	12	9.27e-01	1.52e-02	9.70e-01
Signaling by BRAF and RAF1 fusions	58	9.30e-01	6.64e-03	9.72e-01
Maturation of nucleoprotein	11	9.31e-01	1.50e-02	9.73e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	9.33e-01	-8.16e-03	9.74e-01
AURKA Activation by TPX2	69	9.35e-01	-5.66e-03	9.75e-01
Signaling by ERBB2 ECD mutants	16	9.36e-01	1.17e-02	9.75e-01
p38MAPK events	13	9.37e-01	1.27e-02	9.76e-01
TNFR1-induced NFkappaB signaling pathway	25	9.38e-01	-9.02e-03	9.76e-01
TGF-beta receptor signaling activates SMADs	32	9.39e-01	7.85e-03	9.76e-01
Regulation of TP53 Activity	147	9.39e-01	-3.64e-03	9.76e-01
FLT3 signaling in disease	27	9.43e-01	7.99e-03	9.79e-01
Effects of PIP2 hydrolysis	20	9.45e-01	8.99e-03	9.79e-01
Elevation of cytosolic Ca2+ levels	11	9.45e-01	-1.21e-02	9.79e-01
Platelet calcium homeostasis	21	9.46e-01	-8.60e-03	9.80e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	9.47e-01	9.99e-03	9.80e-01
Acyl chain remodelling of PE	20	9.48e-01	8.41e-03	9.81e-01
Pre-NOTCH Expression and Processing	60	9.50e-01	4.68e-03	9.82e-01
AKT phosphorylates targets in the nucleus	10	9.52e-01	1.11e-02	9.83e-01
Diseases of DNA repair	28	9.54e-01	-6.24e-03	9.85e-01
ATF6 (ATF6-alpha) activates chaperones	12	9.55e-01	-9.36e-03	9.85e-01
Transcriptional regulation of pluripotent stem cells	14	9.55e-01	8.64e-03	9.85e-01
Metabolism of porphyrins	20	9.57e-01	7.00e-03	9.85e-01
Sulfur amino acid metabolism	24	9.57e-01	6.34e-03	9.85e-01
Protein-protein interactions at synapses	50	9.58e-01	4.30e-03	9.85e-01
Surfactant metabolism	14	9.58e-01	-8.10e-03	9.85e-01
Prolonged ERK activation events	13	9.60e-01	-8.12e-03	9.85e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	9.63e-01	8.56e-03	9.87e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	9.63e-01	6.99e-03	9.87e-01
TRP channels	11	9.63e-01	8.04e-03	9.87e-01
Biological oxidations	130	9.65e-01	-2.23e-03	9.87e-01
RHOBTB3 ATPase cycle	10	9.66e-01	-7.87e-03	9.87e-01
Signaling by Insulin receptor	61	9.66e-01	-3.11e-03	9.87e-01
Constitutive Signaling by EGFRvIII	15	9.68e-01	-5.98e-03	9.87e-01
Signaling by EGFRvIII in Cancer	15	9.68e-01	-5.98e-03	9.87e-01
MAP2K and MAPK activation	34	9.68e-01	-3.92e-03	9.87e-01
Uptake and function of anthrax toxins	11	9.69e-01	-6.86e-03	9.87e-01
Signalling to RAS	19	9.69e-01	5.11e-03	9.87e-01
Pyrimidine salvage	10	9.73e-01	6.27e-03	9.90e-01
Downregulation of TGF-beta receptor signaling	26	9.73e-01	3.77e-03	9.90e-01
PINK1-PRKN Mediated Mitophagy	21	9.77e-01	-3.70e-03	9.93e-01
Basigin interactions	20	9.78e-01	-3.53e-03	9.94e-01
Reduction of cytosolic Ca++ levels	10	9.79e-01	-4.76e-03	9.94e-01
Reproduction	64	9.81e-01	-1.76e-03	9.95e-01
Cardiac conduction	89	9.82e-01	1.39e-03	9.95e-01
Tie2 Signaling	16	9.86e-01	-2.60e-03	9.98e-01
SHC1 events in ERBB2 signaling	19	9.88e-01	-1.97e-03	9.99e-01
Eicosanoid ligand-binding receptors	12	9.89e-01	-2.34e-03	9.99e-01
Heparan sulfate/heparin (HS-GAG) metabolism	39	9.89e-01	1.30e-03	9.99e-01
Apoptotic cleavage of cellular proteins	33	9.90e-01	-1.32e-03	9.99e-01
Toll Like Receptor 4 (TLR4) Cascade	124	9.92e-01	-5.34e-04	1.00e+00
Metabolism of folate and pterines	17	9.93e-01	-1.21e-03	1.00e+00
Regulation of beta-cell development	18	9.94e-01	-9.52e-04	1.00e+00
Glucagon-type ligand receptors	16	9.94e-01	-1.00e-03	1.00e+00
Activation of BAD and translocation to mitochondria	14	9.97e-01	6.12e-04	1.00e+00
Generation of second messenger molecules	30	9.97e-01	3.49e-04	1.00e+00
Negative regulation of FGFR3 signaling	22	9.98e-01	3.21e-04	1.00e+00
Activation of ATR in response to replication stress	29	9.98e-01	2.59e-04	1.00e+00
DAP12 interactions	33	9.98e-01	2.27e-04	1.00e+00
Killing mechanisms	10	9.99e-01	3.02e-04	1.00e+00
WNT5:FZD7-mediated leishmania damping	10	9.99e-01	3.02e-04	1.00e+00
Loss of Nlp from mitotic centrosomes	66	1.00e+00	-9.57e-06	1.00e+00
Loss of proteins required for interphase microtubule organization from the centrosome	66	1.00e+00	-9.57e-06	1.00e+00
Signaling by ERBB2	45	1.00e+00	-7.01e-06	1.00e+00

---

Detailed Gene set reports

Classical antibody-mediated complement activation

Classical antibody-mediated complement activation

	193
set	Classical antibody-mediated complement activation
setSize	49
pANOVA	7.86e-23
s.dist	-0.811
p.adjustANOVA	1.11e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
C1QC	-8098
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
C1QA	-7316
IGKV1-12	-7141
IGLV6-57	-5247
IGKC	-4532
IGHV3-23	-2920
C1R	4095
C1S	4607
IGKV1-33	5604

---

Creation of C4 and C2 activators

Creation of C4 and C2 activators

	221
set	Creation of C4 and C2 activators
setSize	53
pANOVA	3.63e-22
s.dist	-0.768
p.adjustANOVA	2.35e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
C1QC	-8098
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
C1QA	-7316
IGKV1-12	-7141
MASP2	-7042
FCN1	-6061
IGLV6-57	-5247
IGKC	-4532
MASP1	-3183
IGHV3-23	-2920
C1R	4095
C1S	4607
IGKV1-33	5604
FCN3	5785

---

Scavenging of heme from plasma

Scavenging of heme from plasma

	1086
set	Scavenging of heme from plasma
setSize	49
pANOVA	4.99e-22
s.dist	-0.796
p.adjustANOVA	2.35e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
JCHAIN	-8307
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
IGHV2-5	-7895
IGLV8-61	-7873
IGHA1	-7806
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
CD163	-7520
IGLV2-11	-7331
IGKV1-12	-7141
HBB	-6775
HBA1	-6577
IGLV6-57	-5247
HP	-4813
IGKC	-4532
IGHV3-23	-2920
LRP1	2468
APOL1	5520
IGKV1-33	5604

---

FCGR activation

FCGR activation

	371
set	FCGR activation
setSize	54
pANOVA	9.72e-22
s.dist	-0.753
p.adjustANOVA	3.43e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
YES1	-7544
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
FCGR2A	-6859
FGR	-6559
IGLV6-57	-5247
LYN	-4973
IGKC	-4532
FYN	-4434
IGHV3-23	-2920
FCGR3A	-536
HCK	1982
CD247	4704
SRC	5289
IGKV1-33	5604

---

CD22 mediated BCR regulation

CD22 mediated BCR regulation

	124
set	CD22 mediated BCR regulation
setSize	46
pANOVA	8.68e-20
s.dist	-0.775
p.adjustANOVA	2.45e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGHD	-8660
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGHD	-8660
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
IGHV2-5	-7895
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
IGKV1-12	-7141
IGHM	-6441
IGLV6-57	-5247
LYN	-4973
IGKC	-4532
CD79A	-4250
IGHV3-23	-2920
PTPN6	-210
CD22	784
CD79B	2373
IGKV1-33	5604

---

Initial triggering of complement

Initial triggering of complement

	542
set	Initial triggering of complement
setSize	59
pANOVA	3.65e-18
s.dist	-0.654
p.adjustANOVA	8.58e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
C1QC	-8098
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
C1QA	-7316
C2	-7174
IGKV1-12	-7141
MASP2	-7042
FCN1	-6061
IGLV6-57	-5247
IGKC	-4532
MASP1	-3183
IGHV3-23	-2920
CFB	-1898
CFD	2597
C1R	4095
C1S	4607
C4A	5401
IGKV1-33	5604
FCN3	5785
C4B	6397
C3	7095

---

Regulation of Complement cascade

Regulation of Complement cascade

	977
set	Regulation of Complement cascade
setSize	72
pANOVA	6.86e-18
s.dist	-0.587
p.adjustANOVA	1.38e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
ELANE	-8281
IGHV3-11	-8247
IGLV3-19	-8185
C3AR1	-8148
C1QC	-8098
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
C1QA	-7316
C8G	-7252
C2	-7174
IGKV1-12	-7141
CLU	-6913
PROS1	-6484
CD55	-5950
IGLV6-57	-5247
CD46	-4603
CFH	-4538
IGKC	-4532
CFI	-3132
IGHV3-23	-2920
CFB	-1898
C6	-1841
C7	-1796
C5	-1632
CD59	-843
C5AR2	-647
CR1	2938
CD81	3762
C5AR1	4051
C1R	4095
SERPING1	4305
C1S	4607
C4A	5401
IGKV1-33	5604
C4B	6397
C3	7095

---

Role of LAT2/NTAL/LAB on calcium mobilization

Role of LAT2/NTAL/LAB on calcium mobilization

	1044
set	Role of LAT2/NTAL/LAB on calcium mobilization
setSize	53
pANOVA	1.63e-17
s.dist	-0.676
p.adjustANOVA	2.87e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
PIK3CB	-6671
SOS1	-6323
PIK3CA	-5439
IGLV6-57	-5247
LYN	-4973
IGKC	-4532
FYN	-4434
IGHV3-23	-2920
PDPK1	-1669
GRB2	-787
GAB2	1024
PIK3R2	2602
LAT2	3357
SHC1	4009
IGKV1-33	5604
PIK3R1	6465

---

Complement cascade

Complement cascade

	205
set	Complement cascade
setSize	77
pANOVA	3.33e-17
s.dist	-0.556
p.adjustANOVA	5.23e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
C1QB	-8582
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
ELANE	-8281
IGHV3-11	-8247
IGLV3-19	-8185
C3AR1	-8148
C1QC	-8098
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
C1QA	-7316
C8G	-7252
C2	-7174
IGKV1-12	-7141
MASP2	-7042
CLU	-6913
PROS1	-6484
FCN1	-6061
CD55	-5950
IGLV6-57	-5247
CD46	-4603
CFH	-4538
IGKC	-4532
MASP1	-3183
CFI	-3132
IGHV3-23	-2920
CFB	-1898
C6	-1841
C7	-1796
C5	-1632
CD59	-843
C5AR2	-647
CFD	2597
CR1	2938
CD81	3762
C5AR1	4051
C1R	4095
SERPING1	4305
C1S	4607
C4A	5401
IGKV1-33	5604
FCN3	5785
C4B	6397
C3	7095

---

Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors

	111
set	Binding and Uptake of Ligands by Scavenger Receptors
setSize	75
pANOVA	7.75e-17
s.dist	-0.556
p.adjustANOVA	1.09e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOB	-8711
MARCO	-8708
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOB	-8711
MARCO	-8708
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
JCHAIN	-8307
SSC5D	-8275
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
IGHV2-5	-7895
IGLV8-61	-7873
IGHA1	-7806
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
CD163	-7520
STAB1	-7347
IGLV2-11	-7331
IGKV1-12	-7141
COL3A1	-6966
HBB	-6775
HBA1	-6577
HSP90B1	-6513
SCARB1	-6429
CD36	-5611
IGLV6-57	-5247
HP	-4813
MSR1	-4797
SCARA5	-4769
IGKC	-4532
FTH1	-4178
HSP90AA1	-4069
COLEC12	-4047
MASP1	-3183
IGHV3-23	-2920
HYOU1	-2566
HSPH1	-999
CALR	1213
FTL	1254
LRP1	2468
COL1A2	2647
SCARF1	4135
COL4A2	4560
COL4A1	4943
APOL1	5520
IGKV1-33	5604
COL1A1	5899
SPARC	7072
APOE	7083
SAA1	7144

---

Role of phospholipids in phagocytosis

Role of phospholipids in phagocytosis

	1045
set	Role of phospholipids in phagocytosis
setSize	65
pANOVA	8.01e-16
s.dist	-0.577
p.adjustANOVA	1.03e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
FCGR2A	-6859
ITPR2	-6797
PIK3CB	-6671
PRKCD	-5561
PIK3CA	-5439
IGLV6-57	-5247
PLD1	-5056
ITPR1	-4601
IGKC	-4532
IGHV3-23	-2920
PRKCE	-1533
FCGR3A	-536
PLCG2	133
PLPP5	498
PLA2G6	1040
PIK3R2	2602
PLCG1	3502
ITPR3	4090
CD247	4704
PLD3	5072
IGKV1-33	5604
PLD2	5712
PIK3R1	6465
AHCYL1	6766

---

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

	76
set	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
setSize	69
pANOVA	1.45e-15
s.dist	-0.555
p.adjustANOVA	1.71e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGHD	-8660
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGHD	-8660
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
IGHV2-5	-7895
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
SYK	-7265
SH3KBP1	-7233
IGKV1-12	-7141
ITPR2	-6797
BTK	-6686
IGHM	-6441
SOS1	-6323
BLNK	-6199
IGLV6-57	-5247
DAPP1	-4992
LYN	-4973
TRPC1	-4906
ITPR1	-4601
IGKC	-4532
FYN	-4434
CD79A	-4250
ORAI2	-3919
IGHV3-23	-2920
ORAI1	-2776
VAV1	-788
GRB2	-787
PTPN6	-210
PIK3CD	66
PLCG2	133
NCK1	742
CD22	784
PIK3AP1	887
CD79B	2373
STIM1	3197
ITPR3	4090
IGKV1-33	5604
PIK3R1	6465
AHCYL1	6766
CALM1	6889

---

Metabolism of RNA

Metabolism of RNA

	644
set	Metabolism of RNA
setSize	676
pANOVA	2.55e-14
s.dist	0.173
p.adjustANOVA	2.77e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYC	7103
UBB	7069
HSPA1A	7054
ZFP36	7042
UBC	7001
THOC3	6999
MT-ND4L	6960
ELAC2	6891
POLR2A	6867
MT-RNR2	6815
MT-CYB	6787
MT-ATP6	6746
PRPF6	6742
NOB1	6721
DCP1B	6716
MRM3	6713
GPKOW	6683
FIP1L1	6674
ZFP36L1	6653
IGF2	6635

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYC	7103
UBB	7069
HSPA1A	7054
ZFP36	7042
UBC	7001
THOC3	6999
MT-ND4L	6960
ELAC2	6891
POLR2A	6867
MT-RNR2	6815
MT-CYB	6787
MT-ATP6	6746
PRPF6	6742
NOB1	6721
DCP1B	6716
MRM3	6713
GPKOW	6683
FIP1L1	6674
ZFP36L1	6653
IGF2	6635
PQBP1	6631
PSMB3	6540
RPSA	6533
MT-RNR1	6504
NOP56	6500
SNRNP200	6461
RRP7A	6455
SUGP1	6452
EIF4A3	6413
PPP2R1A	6382
HSPB1	6365
RPL36AL	6352
DDX23	6343
CSTF1	6301
MT-CO2	6275
XAB2	6250
TFIP11	6189
MT-ND1	6158
EIF4A1	6142
POLR2F	6141
ZNF473	6137
SART1	6102
PARN	6097
NXT1	6067
PSMD3	6058
PRPF19	6019
ADAT3	5998
NAT10	5973
ZMAT5	5970
SF3B3	5961
PSMD1	5956
MT-TP	5941
SNRNP40	5937
DHX38	5936
MT-CO1	5923
PSMB5	5903
PSMB8	5892
RRP1	5882
PUF60	5876
ADAR	5872
CDKAL1	5852
RPS2	5798
UPF1	5791
EFTUD2	5783
SKIV2L	5782
NOC4L	5740
PRPF8	5696
RPLP2	5670
SNW1	5649
ERCC3	5643
NCL	5641
RPS15	5631
BYSL	5616
FBL	5583
RPP21	5581
NUP62	5560
PCF11	5547
RPS11	5527
SUPT5H	5513
RPS3	5509
CLP1	5508
PSMB9	5506
RPL9	5484
EIF4G1	5479
PELP1	5454
PCBP1	5443
RPL19	5434
SNUPN	5403
SMG8	5396
PSMC3	5388
PSMD2	5344
PSMB6	5343
MT-ND4	5341
APOBEC3A	5316
EXOSC10	5261
PRPF31	5252
CD2BP2	5222
RPS9	5216
RPL18	5215
LAS1L	5214
EDC4	5203
PRPF3	5199
ERCC2	5193
DCPS	5163
CPSF3	5153
SNRPC	5142
RPLP1	5137
NUP88	5134
SNRNP35	5123
SF3A1	5092
PES1	5074
GTF2H4	5063
RPL13A	5043
PSMD4	5037
UBA52	5032
PDCD11	5031
PSME2	5022
PSMD8	5019
UTP3	5008
PSMB4	4992
RPL37A	4988
IMP4	4971
SNRPD2	4957
SNRNP25	4956
NUP188	4942
PUS1	4924
PRCC	4916
SF3B2	4915
NUP98	4904
MT-ND5	4896
EDC3	4883
RPL29	4856
RPL23A	4851
HNRNPM	4820
ALYREF	4779
NUP160	4771
DDX42	4762
RPS19	4757
SRRM2	4754
RPL38	4753
RPS16	4751
FUS	4735
TBL3	4732
METTL1	4725
TSEN34	4723
THOC5	4680
MT-ND2	4674
SNRPN	4663
BMS1	4629
ACTB	4598
RPS28	4590
EXOSC5	4553
RPL28	4548
FTSJ3	4541
CHERP	4489
RPL3L	4465
CPSF7	4455
SYMPK	4444
POLDIP3	4433
FTSJ1	4416
CPSF4	4410
RTCB	4406
HNRNPL	4402
SEC13	4359
RPL14	4354
RPS15A	4345
ZRSR2	4338
CPSF1	4337
RPL37	4334
GEMIN5	4285
RPL32	4253
PSMC4	4202
POP4	4193
PRMT5	4170
POLR2I	4168
MT-ND3	4150
NHP2	4147
PPIE	4144
TSR1	4137
DDX49	4136
CTNNBL1	4127
SF3A2	4120
TPR	4113
WDR33	4055
GSPT2	4044
POM121	4042
CNOT3	4037
PSMC5	4020
WDR3	3995
SMG6	3976
TRIT1	3962
SRSF7	3945
NSUN4	3932
TGS1	3888
RIOK1	3861
RPL41	3826
RPL8	3810
RPL36	3737
QTRT1	3722
EMG1	3716
RPLP0	3705
NUP205	3685
GEMIN7	3659
USP39	3635
WDR18	3594
CWC25	3591
TFB1M	3582
EXOSC4	3577
YBX1	3458
ANP32A	3443
POLR2L	3442
FAU	3409
SRRT	3304
PSMB10	3266
U2AF2	3244
RPS5	3240
CSNK1D	3222
RRP9	3191
DDX1	3182
POP7	3151
NOL6	3082
NOP2	3064
SNRPB	3060
HSPA8	3050
PSMB7	3031
POLR2E	3025
LSM10	3023
HNRNPA0	2969
POM121C	2955
RPL30	2947
PAN2	2945
LAGE3	2911
ISY1	2866
NSUN2	2864
URM1	2861
GTF2F1	2803
BCAS2	2790
PSMC1	2778
CSTF2T	2769
RPS29	2765
SNU13	2710
NXF1	2625
GLE1	2621
TRMT61B	2562
OSGEP	2520
RPS21	2509
RPL7A	2493
HSD17B10	2471
TRMT112	2470
SRSF9	2457
RPL13	2437
NUP93	2426
TNKS1BP1	2402
PSMA5	2400
SRSF4	2390
SF3B5	2361
ADAT1	2302
PRPF38A	2273
RPL12	2246
DKC1	2235
MRM2	2231
NOP10	2210
GEMIN4	2199
SNRPA	2192
NOP14	2174
DDX39B	2151
PSMC2	2124
SMG9	2098
UPF2	2033
HNRNPU	2030
TRMT12	2011
RPS13	2004
LSM7	1988
POLR2H	1965
EBNA1BP2	1940
DHX9	1933
MAPK14	1922
SRSF6	1919
TRMT44	1858
TRMT9B	1848
PSMB2	1820
DUS2	1816
IMP3	1813
PSMB1	1804
SMG5	1765
TSEN54	1764
NUP155	1758
PSMA7	1752
PABPN1	1738
BOP1	1733
TRMT1	1701
ADAT2	1699
RPS18	1690
RPL23	1687
DHX16	1678
RPL31	1652
RBM5	1617
MAGOH	1590
NUP133	1546
METTL3	1506
CNOT1	1502
RPL18A	1485
KHSRP	1456
RPS10	1452
RPS14	1447
TSEN15	1429
HNRNPK	1428
TRDMT1	1404
RPL27	1373
SNRNP70	1367
EXOSC1	1359
RPL10	1356
SF3B1	1346
RAN	1342
PSMD7	1338
GNL3	1331
EIF4B	1330
RPS23	1326
TTC37	1314
BUD31	1312
RPS20	1305
HEATR1	1299
UTP20	1284
NUP214	1222
TYW1	1197
RAE1	1163
MT-TS1	1145
RCL1	1137
NUP85	1136
PSMD9	1114
PSMA1	1108
POLR2J	1069
RPL27A	1058
PSMD13	1057
DDX20	1053
EXOSC2	1035
SMN1	1009
CSTF2	1002
PNO1	987
MTO1	916
THG1L	908
CNOT10	905
UTP14A	828
PSMD6	790
XRN2	787
RBM22	777
RIOK2	762
THOC1	758
POLR2B	739
TRMT61A	735
PSMF1	734
CASC3	674
ZC3H11A	641
WDR4	631
MPHOSPH6	625
PSME1	622
MPHOSPH10	618
CNOT2	616
ELAVL1	613
UTP4	587
DDX47	585
LCMT2	569
GAR1	568
ENPP2	546
MT-CO3	542
RPL4	516
SF3A3	480
RPL15	466
HNRNPR	437
CNOT4	422
RPL35	420
APOBEC3C	417
RPS12	414
WBP11	398
THOC6	386
RPL34	379
TP53RK	366
POLR2G	336
RPS27	304
RPL39	225
PPIL3	222
RPL3	207
LTV1	165
UTP18	151
RPS27L	146
RNPS1	144
HNRNPUL1	139
NUP153	90
RPL7	-2
MT-TN	-16
WDR46	-24
PSMA2	-124
PRPF4	-126
DHX37	-159
RPS27A	-177
SEH1L	-247
TSR3	-281
POLR2C	-311
RPL26	-335
HNRNPD	-353
DNAJC8	-362
NUP35	-363
SLBP	-414
EIF4A2	-418
PSMA6	-423
ISG20L2	-516
DCP1A	-519
RPL10A	-551
SNRNP27	-593
RPS17	-616
PDCD7	-643
RPL17	-661
CHTOP	-666
PSMD11	-674
CSNK1E	-692
PSMD5	-792
PPP2R2A	-803
UTP25	-807
RBMX	-811
DHX15	-827
LSM2	-828
RPS24	-856
HNRNPH1	-906
TRMT6	-926
MAPK11	-930
SRSF2	-978
TXNL4A	-990
CRNKL1	-1013
SF1	-1014
RBM8A	-1037
AAAS	-1069
TRMU	-1075
HNRNPF	-1088
SMG7	-1094
TRMT5	-1097
RPS8	-1110
EPRS1	-1134
NOL9	-1148
PPIH	-1157
POLR2D	-1176
GTPBP3	-1177
NIP7	-1233
CTU2	-1240
NCBP2	-1265
GEMIN2	-1285
CWC15	-1293
RPS4Y1	-1305
HBS1L	-1320
SEM1	-1355
TRA2B	-1363
NUP107	-1364
NT5C3B	-1365
PATL1	-1405
CWC22	-1433
DDX46	-1446
PSMD14	-1462
RPL21	-1476
PUS3	-1485
DDX39A	-1517
PUS7	-1581
TSEN2	-1585
HNRNPH2	-1587
PLRG1	-1637
WDR43	-1660
PSME3	-1684
SNRPG	-1686
PCBP2	-1739
SNRPA1	-1744
RPP30	-1749
RPL26L1	-1755
UPF3B	-1799
WBP4	-1812
NUP42	-1817
RPL6	-1834
HNRNPA1	-1850
RPP38	-1912
RPL35A	-1915
RPL5	-2001
MNAT1	-2014
MRM1	-2068
PSMC6	-2073
UTP15	-2083
RRP36	-2085
SRSF5	-2130
NUP50	-2132
PSMA4	-2141
MTERF4	-2176
YWHAB	-2189
PPIL1	-2208
RPS4X	-2225
LSM6	-2245
PPWD1	-2258
RPS6	-2299
TRMT13	-2304
UTP6	-2341
CCAR1	-2361
RPL11	-2374
SLU7	-2393
UPF3A	-2450
THADA	-2493
SRRM1	-2499
NOL11	-2505
MT-TA	-2508
DIS3	-2531
RPS3A	-2553
HNRNPA2B1	-2559
WDR61	-2570
RTRAF	-2591
ZCRB1	-2607
CTU1	-2619
HNRNPC	-2647
TNFSF13	-2651
SNRNP48	-2799
WDR75	-2802
APOBEC2	-2818
NOL12	-2845
POP1	-2864
PTBP1	-2899
MT-ATP8	-2900
PPIL6	-2915
GSPT1	-2996
MAPKAPK2	-3012
XPOT	-3045
RPP14	-3047
SRSF1	-3058
C2orf49	-3087
CDC40	-3094
PAIP1	-3108
RBM28	-3115
RPS25	-3129
WDR77	-3141
CDC5L	-3156
PHF5A	-3176
RPL22	-3228
POLR2K	-3290
THUMPD1	-3334
RBM17	-3342
CNOT8	-3428
SRSF11	-3431
RPL22L1	-3463
RPP25	-3464
RPL24	-3530
MTREX	-3560
SARNP	-3562
AQR	-3568
LSM1	-3592
ETF1	-3636
NUP43	-3666
ALKBH8	-3670
PSMA3	-3674
RIOK3	-3677
UTP11	-3689
THOC2	-3698
METTL14	-3770
DDX52	-3774
SF3B4	-3829
DDX5	-3831
FCF1	-3920
SNRPB2	-3991
GEMIN8	-4088
WDR12	-4090
PHAX	-4091
THOC7	-4138
GTF2H1	-4140
DCP2	-4168
GTF2H5	-4189
NOP58	-4217
SNRPF	-4222
IGF2BP2	-4259
CNOT11	-4263
NCBP1	-4287
U2AF1L4	-4290
PSMD10	-4314
EXOSC9	-4334
CLNS1A	-4351
GTF2H3	-4371
SENP3	-4374
SET	-4405
CNOT7	-4415
PSMD12	-4430
NUP54	-4512
PRORP	-4513
DDX21	-4531
PABPC1	-4540
RPS7	-4550
EXOSC8	-4755
SNRPD1	-4759
ADARB1	-4765
SF3B6	-4817
RNPC3	-4869
MAGOHB	-4885
DIMT1	-4887
GEMIN6	-5018
TRNT1	-5027
AKT1	-5072
NUP37	-5077
TRMT10C	-5078
EXOSC3	-5079
QTRT2	-5151
HNRNPA3	-5175
EIF4E	-5182
NUP210	-5199
TEX10	-5212
LSM3	-5234
PNRC2	-5279
GCFC2	-5282
TYW5	-5314
NUP58	-5351
TPRKB	-5355
CDK7	-5381
XPO1	-5416
FYTTD1	-5421
FAM98B	-5483
PPIL4	-5488
PRKCD	-5561
GTF2H2	-5637
RPP40	-5654
ZBTB8OS	-5667
SRSF3	-5730
LSM5	-5736
RPL36A	-5827
CWC27	-5846
CPSF2	-5853
WTAP	-5898
PPP2CA	-5902
KRR1	-5948
YWHAZ	-6003
RNGTT	-6040
ERI1	-6093
SNRPE	-6117
PSME4	-6160
C1D	-6214
NSUN6	-6268
RANBP2	-6291
U2AF1	-6478
LSM11	-6479
LSM4	-6526
PRKCA	-6547
TRMT10A	-6561
TNPO1	-6603
POP5	-6606
CNOT6	-6644
CSTF3	-6695
SNRPD3	-6730
MT-ND6	-6779
PRPF40A	-6796
CCNH	-6831
RNMT	-6903
SYF2	-6922
XRN1	-6937
NDC1	-7051
SMNDC1	-7091
DDX6	-7199
WDR36	-7214
PAPOLA	-7285
DCAF13	-7300
CNOT6L	-7312
RPS26	-7408
MT-TC	-7425
PAN3	-7444
LSM8	-7450
TRMT11	-7496
GPRC5A	-7521
UTP14C	-7565
MT-TY	-7659
U2SURP	-7780
NUDT21	-7785
EXOSC6	-8109
SMG1	-8231
CD44	-8311
GTF2F2	-8382
SRSF10	-8414
TYW3	-8421
EXOSC7	-8489
H19	-8624
PWP2	-8653

---

FCERI mediated Ca+2 mobilization

FCERI mediated Ca+2 mobilization

	368
set	FCERI mediated Ca+2 mobilization
setSize	67
pANOVA	4.38e-14
s.dist	-0.533
p.adjustANOVA	4.41e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
ITPR2	-6797
BTK	-6686
SOS1	-6323
IGLV6-57	-5247
LYN	-4973
LCP2	-4775
ITPR1	-4601
IGKC	-4532
GRAP2	-3400
NFATC2	-3196
IGHV3-23	-2920
PPP3R1	-2521
TEC	-2071
LAT	-1693
NFATC1	-1357
PPP3CA	-1107
PPP3CB	-967
VAV1	-788
GRB2	-787
PLCG2	133
ITK	250
NFATC3	541
VAV3	716
VAV2	2529
PLCG1	3502
SHC1	4009
ITPR3	4090
IGKV1-33	5604
AHCYL1	6766
CALM1	6889

---

FCGR3A-mediated IL10 synthesis

FCGR3A-mediated IL10 synthesis

	372
set	FCGR3A-mediated IL10 synthesis
setSize	77
pANOVA	1.45e-13
s.dist	-0.487
p.adjustANOVA	1.36e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
PRKACB	-7886
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
YES1	-7544
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
FCGR2A	-6859
ITPR2	-6797
FGR	-6559
PRKAR2B	-6370
PRKX	-5513
IGLV6-57	-5247
LYN	-4973
ITPR1	-4601
IGKC	-4532
FYN	-4434
PRKAR2A	-3291
IGHV3-23	-2920
CREB1	-2036
ADCY7	-1634
ADCY1	-1051
FCGR3A	-536
PLCG2	133
PRKAR1B	704
PRKACA	933
ADCY9	1440
ADCY2	1607
ADCY6	1874
HCK	1982
ADCY5	3046
PLCG1	3502
ITPR3	4090
PRKAR1A	4240
CD247	4704
SRC	5289
IGKV1-33	5604
ADCY4	5725
ADCY3	5809
AHCYL1	6766
CALM1	6889

---

FCGR3A-mediated phagocytosis

FCGR3A-mediated phagocytosis

	373
set	FCGR3A-mediated phagocytosis
setSize	102
pANOVA	3.13e-12
s.dist	-0.4
p.adjustANOVA	2.46e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
MYO5A	-7688
YES1	-7544
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
ARPC3	-7025
BTK	-6686
CRK	-6681
FGR	-6559
CDC42	-5909
NCKAP1	-5855
ACTR2	-5629
WASL	-5406
ARPC1B	-5365
IGLV6-57	-5247
BAIAP2	-5202
ARPC2	-5121
LYN	-4973
ACTR3	-4907
IGKC	-4532
ABI2	-4465
FYN	-4434
WIPF2	-3984
WASF1	-3856
WAS	-3848
WIPF3	-3685
ARPC5	-3020
IGHV3-23	-2920
NCKAP1L	-2883
WASF2	-2881
MYO9B	-2121
MYH2	-1745
PTK2	-936
VAV1	-788
GRB2	-787
RAC1	-651
FCGR3A	-536
CYFIP2	-73
ABI1	-27
WIPF1	510
BRK1	573
VAV3	716
NCK1	742
WASF3	945
ABL1	1363
ARPC4	1580
HCK	1982
MAPK1	2069
VAV2	2529
MYH9	2741
MYO1C	3202
ARPC1A	3340
ACTG1	3415
NCKIPSD	3524
MAPK3	3978
ELMO1	4078
ACTB	4598
CYFIP1	4618
CD247	4704
SRC	5289
IGKV1-33	5604
DOCK1	6051
ELMO2	6350
MYO10	6528

---

Leishmania phagocytosis

Leishmania phagocytosis

	609
set	Leishmania phagocytosis
setSize	102
pANOVA	3.13e-12
s.dist	-0.4
p.adjustANOVA	2.46e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
MYO5A	-7688
YES1	-7544
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
ARPC3	-7025
BTK	-6686
CRK	-6681
FGR	-6559
CDC42	-5909
NCKAP1	-5855
ACTR2	-5629
WASL	-5406
ARPC1B	-5365
IGLV6-57	-5247
BAIAP2	-5202
ARPC2	-5121
LYN	-4973
ACTR3	-4907
IGKC	-4532
ABI2	-4465
FYN	-4434
WIPF2	-3984
WASF1	-3856
WAS	-3848
WIPF3	-3685
ARPC5	-3020
IGHV3-23	-2920
NCKAP1L	-2883
WASF2	-2881
MYO9B	-2121
MYH2	-1745
PTK2	-936
VAV1	-788
GRB2	-787
RAC1	-651
FCGR3A	-536
CYFIP2	-73
ABI1	-27
WIPF1	510
BRK1	573
VAV3	716
NCK1	742
WASF3	945
ABL1	1363
ARPC4	1580
HCK	1982
MAPK1	2069
VAV2	2529
MYH9	2741
MYO1C	3202
ARPC1A	3340
ACTG1	3415
NCKIPSD	3524
MAPK3	3978
ELMO1	4078
ACTB	4598
CYFIP1	4618
CD247	4704
SRC	5289
IGKV1-33	5604
DOCK1	6051
ELMO2	6350
MYO10	6528

---

Parasite infection

Parasite infection

	810
set	Parasite infection
setSize	102
pANOVA	3.13e-12
s.dist	-0.4
p.adjustANOVA	2.46e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
MYO5A	-7688
YES1	-7544
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
ARPC3	-7025
BTK	-6686
CRK	-6681
FGR	-6559
CDC42	-5909
NCKAP1	-5855
ACTR2	-5629
WASL	-5406
ARPC1B	-5365
IGLV6-57	-5247
BAIAP2	-5202
ARPC2	-5121
LYN	-4973
ACTR3	-4907
IGKC	-4532
ABI2	-4465
FYN	-4434
WIPF2	-3984
WASF1	-3856
WAS	-3848
WIPF3	-3685
ARPC5	-3020
IGHV3-23	-2920
NCKAP1L	-2883
WASF2	-2881
MYO9B	-2121
MYH2	-1745
PTK2	-936
VAV1	-788
GRB2	-787
RAC1	-651
FCGR3A	-536
CYFIP2	-73
ABI1	-27
WIPF1	510
BRK1	573
VAV3	716
NCK1	742
WASF3	945
ABL1	1363
ARPC4	1580
HCK	1982
MAPK1	2069
VAV2	2529
MYH9	2741
MYO1C	3202
ARPC1A	3340
ACTG1	3415
NCKIPSD	3524
MAPK3	3978
ELMO1	4078
ACTB	4598
CYFIP1	4618
CD247	4704
SRC	5289
IGKV1-33	5604
DOCK1	6051
ELMO2	6350
MYO10	6528

---

FCERI mediated MAPK activation

FCERI mediated MAPK activation

	369
set	FCERI mediated MAPK activation
setSize	69
pANOVA	3.98e-12
s.dist	-0.483
p.adjustANOVA	2.95e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGLV3-1	-7934
KRAS	-7901
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
SOS1	-6323
MAPK8	-5685
PAK2	-5599
IGLV6-57	-5247
LYN	-4973
NRAS	-4823
LCP2	-4775
IGKC	-4532
MAP3K1	-3982
GRAP2	-3400
IGHV3-23	-2920
LAT	-1693
VAV1	-788
GRB2	-787
RAC1	-651
MAPK9	-611
PLCG2	133
MAP2K7	432
VAV3	716
MAPK10	1695
MAP2K4	1951
MAPK1	2069
VAV2	2529
PLCG1	3502
MAPK3	3978
SHC1	4009
HRAS	5006
IGKV1-33	5604
PAK1	6509
JUN	7163
FOS	7164

---

Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

	163
set	Cell surface interactions at the vascular wall
setSize	146
pANOVA	7.01e-11
s.dist	-0.313
p.adjustANOVA	4.94e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOB	-8711
IGLV3-25	-8702
IGKV1D-39	-8677
ITGB3	-8655
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOB	-8711
IGLV3-25	-8702
IGKV1D-39	-8677
ITGB3	-8655
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
CD2	-8369
IGKV2-28	-8351
SDC1	-8347
IGHV4-59	-8339
CD44	-8311
JCHAIN	-8307
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
SLC7A8	-7947
IGLV3-1	-7934
KRAS	-7901
IGHV2-5	-7895
IGLV8-61	-7873
SLC7A7	-7856
ITGAV	-7838
SDC2	-7832
IGHA1	-7806
ITGAM	-7762
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
CD47	-7687
SPN	-7611
YES1	-7544
CD58	-7532
FN1	-7429
IGLV2-11	-7331
IGKV1-12	-7141
PROCR	-7111
ITGA5	-6957
SLC16A3	-6801
FCER1G	-6672
PIK3CB	-6671
CD177	-6543
PROS1	-6484
IGHM	-6441
SOS1	-6323
MERTK	-6249
CAV1	-6027
CD84	-5801
ITGB1	-5747
CEACAM6	-5739
CEACAM8	-5728
ATP1B1	-5668
PIK3CA	-5439
SELP	-5430
PTPN11	-5259
IGLV6-57	-5247
PF4	-5169
DOK2	-5034
LYN	-4973
NRAS	-4823
TGFB1	-4611
IGKC	-4532
SLC16A1	-4490
FYN	-4434
ITGA4	-3338
GYPA	-3064
ITGAL	-2947
IGHV3-23	-2920
ITGB2	-2807
ATP1B3	-2801
JAM3	-2596
GYPB	-2328
CEACAM3	-2279
CD99	-2109
ATP1B2	-2041
JAM2	-1798
GRB2	-787
F11R	-736
LCK	-474
CD99L2	-347
PTPN6	-210
ANGPT1	-188
ITGAX	-155
TSPAN7	279
TNFRSF10B	392
TREM1	620
SDC4	1098
TNFRSF10D	1104
SELL	1130
GAS6	1259
ITGA6	1320
SLC7A5	1353
BSG	1665
GYPC	2170
TEK	2260
PIK3R2	2602
CD48	2629
SLC16A8	2871
SELPLG	2921
JAML	3450
PPIA	3464
PLCG1	3502
GPC1	3507
MIF	3956
SHC1	4009
GRB14	4383
SDC3	4482
CEACAM1	4603
ESAM	4662
TNFRSF10A	4983
ANGPT2	4994
HRAS	5006
PECAM1	5176
SRC	5289
PICK1	5393
IGKV1-33	5604
SLC7A6	5623
PPIL2	5654
SLC3A2	6038
ITGA3	6040
INPP5D	6167
GLG1	6203
CD74	6368
PIK3R1	6465
SIRPA	6591
L1CAM	6930
THBD	6966

---

Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

	1005
set	Regulation of actin dynamics for phagocytic cup formation
setSize	103
pANOVA	1.6e-10
s.dist	-0.365
p.adjustANOVA	1.07e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
MYO5A	-7688
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
ARPC3	-7025
FCGR2A	-6859
BTK	-6686
CRK	-6681
CDC42	-5909
NCKAP1	-5855
ACTR2	-5629
WASL	-5406
ARPC1B	-5365
IGLV6-57	-5247
BAIAP2	-5202
ARPC2	-5121
ACTR3	-4907
IGKC	-4532
ABI2	-4465
HSP90AA1	-4069
WIPF2	-3984
WASF1	-3856
WAS	-3848
WIPF3	-3685
ARPC5	-3020
IGHV3-23	-2920
NCKAP1L	-2883
WASF2	-2881
MYO9B	-2121
MYH2	-1745
LIMK1	-1361
PTK2	-936
VAV1	-788
GRB2	-787
RAC1	-651
FCGR3A	-536
CYFIP2	-73
ABI1	-27
WIPF1	510
BRK1	573
VAV3	716
NCK1	742
WASF3	945
ABL1	1363
ARPC4	1580
MAPK1	2069
VAV2	2529
MYH9	2741
MYO1C	3202
NF2	3220
ARPC1A	3340
ACTG1	3415
NCKIPSD	3524
MAPK3	3978
CFL1	4031
ELMO1	4078
ACTB	4598
CYFIP1	4618
CD247	4704
IGKV1-33	5604
DOCK1	6051
ELMO2	6350
PAK1	6509
MYO10	6528
HSP90AB1	6626

---

Translation

Translation

	1317
set	Translation
setSize	293
pANOVA	5.85e-10
s.dist	0.211
p.adjustANOVA	3.75e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	6896
MT-RNR2	6815
SRPRA	6752
EARS2	6546
RPSA	6533
MT-RNR1	6504
AIMP2	6440
EEF1A2	6354
RPL36AL	6352
WARS1	6326
EIF2B4	6247
HARS2	6245
TARS2	6219
EIF4A1	6142
SRP68	6084
EIF2B2	6079
ERAL1	6014
MRPL28	5914
RPS2	5798
SARS2	5762

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	6896
MT-RNR2	6815
SRPRA	6752
EARS2	6546
RPSA	6533
MT-RNR1	6504
AIMP2	6440
EEF1A2	6354
RPL36AL	6352
WARS1	6326
EIF2B4	6247
HARS2	6245
TARS2	6219
EIF4A1	6142
SRP68	6084
EIF2B2	6079
ERAL1	6014
MRPL28	5914
RPS2	5798
SARS2	5762
MRPS2	5682
RPLP2	5670
SARS1	5645
RPS15	5631
EEF1D	5602
MRPL24	5589
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
OXA1L	5423
MRPL2	5350
EIF3D	5291
EIF3A	5270
MRPL43	5263
FARSA	5248
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
MRPL23	5125
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988
QARS1	4982
MRPL55	4952
EEF2	4907
RPL29	4856
RPL23A	4851
YARS2	4810
RPS19	4757
RPL38	4753
RPS16	4751
MRPS26	4715
RPN2	4599
RPS28	4590
RPL28	4548
EIF2B3	4474
RPL3L	4465
LARS1	4437
EIF2B5	4391
RPL14	4354
RPS15A	4345
RPL37	4334
MRPS18B	4289
MRPL49	4280
MTRF1L	4278
RPL32	4253
KARS1	4247
MRPL9	4155
MRPS5	4151
MRPL16	4072
LARS2	4048
GSPT2	4044
EEF1G	4033
SSR2	3915
MRPL27	3895
MRPL38	3852
AARS1	3835
RPL41	3826
RPL8	3810
MRPS7	3778
RPL36	3737
RPLP0	3705
APEH	3692
EIF3I	3667
AARS2	3638
HARS1	3637
EIF3B	3604
SSR4	3532
AURKAIP1	3513
VARS1	3504
FAU	3409
SRPRB	3352
FARS2	3345
MRPS11	3320
RPN1	3256
RPS5	3240
EIF3F	3233
EIF3H	3034
MRPL37	3032
FARSB	2964
RPL30	2947
DAP3	2889
EIF2B1	2836
MRPL48	2777
RPS29	2765
MRPL10	2747
RPS21	2509
RPL7A	2493
TRMT112	2470
MRPS9	2440
RPL13	2437
MRPS18C	2425
MRPS18A	2286
MRPS24	2269
RPL12	2246
GADD45GIP1	2208
SEC61B	2100
MRPL53	2040
RPS13	2004
MARS1	1877
EIF3K	1840
MRPL22	1838
MRPL17	1766
MRPL58	1754
RPS18	1690
RPL23	1687
EEF1A1P5	1672
MRPL54	1653
RPL31	1652
TUFM	1644
PARS2	1576
EEF1B2	1575
RPL18A	1485
MTFMT	1458
RPS10	1452
RPS14	1447
PPA1	1421
MRPS31	1389
RPL27	1373
CARS1	1364
RPL10	1356
IARS2	1343
EIF4B	1330
RPS23	1326
MRPS34	1307
RPS20	1305
YARS1	1274
GFM1	1253
MRPL52	1171
GFM2	1120
RPL27A	1058
MRPL14	797
MRPL13	723
IARS1	690
MRPL21	676
MRRF	675
SEC61A1	605
RPL4	516
MRPS15	511
RPL15	466
RPL35	420
RPS12	414
MRPL51	396
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
GARS1	10
RPL7	-2
MRPL45	-10
DDOST	-60
MRPL39	-90
RPS27A	-177
MARS2	-303
CHCHD1	-334
RPL26	-335
MRPL40	-415
EIF4A2	-418
MRPS27	-486
TSFM	-523
RPL10A	-551
MRPL4	-571
RPS17	-616
RPL17	-661
MRPS21	-735
WARS2	-849
RPS24	-856
MRPS30	-940
PTCD3	-947
SRP14	-972
MRPS17	-995
TARS1	-1039
RPS8	-1110
EPRS1	-1134
MRPL12	-1155
MRPL30	-1228
VARS2	-1239
RPS4Y1	-1305
MRPS23	-1331
RPL21	-1476
MRPL15	-1541
MRPL41	-1559
MRPL11	-1578
MRPL20	-1630
MRPL18	-1646
EIF2S2	-1692
EEF1A1	-1696
RPL26L1	-1755
NARS1	-1795
MTIF3	-1818
EIF5	-1822
RPL6	-1834
MRPL57	-1884
RPL35A	-1915
RARS2	-1934
MRPL33	-1938
MRPL3	-1998
RPL5	-2001
CARS2	-2166
RPS4X	-2225
RPS6	-2299
MRPL36	-2321
MRPL32	-2346
MRPL46	-2370
RPL11	-2374
RPS3A	-2553
MRPS25	-2584
EIF3M	-2604
EIF2S3	-2635
SRP72	-2637
MRPS6	-2758
MRPS16	-2934
MRPS12	-2989
GSPT1	-2996
RPS25	-3129
MRPL19	-3153
DARS1	-3182
MRPL44	-3184
SEC11C	-3198
MRPS22	-3205
RPL22	-3228
MRPL50	-3303
MTIF2	-3309
SRP54	-3318
MRPS33	-3365
MRPL47	-3439
RPL22L1	-3463
NARS2	-3510
RPL24	-3530
EIF5B	-3535
ETF1	-3636
MRPS28	-3653
SEC61A2	-3667
SPCS2	-3958
MRPS10	-3998
SEC61G	-4094
EIF3E	-4214
EIF2S1	-4256
MRPS14	-4359
N6AMT1	-4412
PABPC1	-4540
RPS7	-4550
SSR1	-4595
DARS2	-4683
EIF1AX	-4691
SEC11A	-4793
SRP9	-4952
MRPS35	-5163
EIF4E	-5182
PPA2	-5238
MRPL35	-5452
EIF3J	-5510
RPL36A	-5827
SRP19	-6026
RARS1	-6241
MRPL34	-6313
SSR3	-6355
MRPL1	-6506
MRPS36	-6628
AIMP1	-6737
EEF1E1	-6757
SPCS1	-7340
RPS26	-7408
MRPL42	-7439
EIF4EBP1	-7964
SPCS3	-7983
TRAM1	-8184

---

rRNA processing

rRNA processing

	1402
set	rRNA processing
setSize	213
pANOVA	1.3e-09
s.dist	0.242
p.adjustANOVA	7.95e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MT-ND4L	6960
ELAC2	6891
MT-RNR2	6815
MT-CYB	6787
MT-ATP6	6746
NOB1	6721
MRM3	6713
RPSA	6533
MT-RNR1	6504
NOP56	6500
RRP7A	6455
RPL36AL	6352
MT-CO2	6275
MT-ND1	6158
NAT10	5973
MT-CO1	5923
RRP1	5882
RPS2	5798
NOC4L	5740
RPLP2	5670

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MT-ND4L	6960
ELAC2	6891
MT-RNR2	6815
MT-CYB	6787
MT-ATP6	6746
NOB1	6721
MRM3	6713
RPSA	6533
MT-RNR1	6504
NOP56	6500
RRP7A	6455
RPL36AL	6352
MT-CO2	6275
MT-ND1	6158
NAT10	5973
MT-CO1	5923
RRP1	5882
RPS2	5798
NOC4L	5740
RPLP2	5670
NCL	5641
RPS15	5631
BYSL	5616
FBL	5583
RPP21	5581
RPS11	5527
RPS3	5509
RPL9	5484
PELP1	5454
RPL19	5434
MT-ND4	5341
EXOSC10	5261
RPS9	5216
RPL18	5215
LAS1L	5214
RPLP1	5137
PES1	5074
RPL13A	5043
UBA52	5032
PDCD11	5031
UTP3	5008
RPL37A	4988
IMP4	4971
MT-ND5	4896
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
TBL3	4732
MT-ND2	4674
BMS1	4629
RPS28	4590
EXOSC5	4553
RPL28	4548
FTSJ3	4541
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
MT-ND3	4150
NHP2	4147
TSR1	4137
DDX49	4136
WDR3	3995
NSUN4	3932
RIOK1	3861
RPL41	3826
RPL8	3810
RPL36	3737
EMG1	3716
RPLP0	3705
WDR18	3594
TFB1M	3582
EXOSC4	3577
FAU	3409
RPS5	3240
CSNK1D	3222
RRP9	3191
NOL6	3082
NOP2	3064
RPL30	2947
RPS29	2765
SNU13	2710
RPS21	2509
RPL7A	2493
HSD17B10	2471
TRMT112	2470
RPL13	2437
RPL12	2246
DKC1	2235
MRM2	2231
NOP10	2210
NOP14	2174
RPS13	2004
EBNA1BP2	1940
IMP3	1813
BOP1	1733
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
EXOSC1	1359
RPL10	1356
GNL3	1331
RPS23	1326
RPS20	1305
HEATR1	1299
UTP20	1284
RCL1	1137
RPL27A	1058
EXOSC2	1035
PNO1	987
UTP14A	828
XRN2	787
RIOK2	762
MPHOSPH6	625
MPHOSPH10	618
UTP4	587
DDX47	585
GAR1	568
MT-CO3	542
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
LTV1	165
UTP18	151
RPS27L	146
RPL7	-2
WDR46	-24
DHX37	-159
RPS27A	-177
TSR3	-281
RPL26	-335
ISG20L2	-516
RPL10A	-551
RPS17	-616
RPL17	-661
CSNK1E	-692
UTP25	-807
RPS24	-856
RPS8	-1110
NOL9	-1148
NIP7	-1233
RPS4Y1	-1305
RPL21	-1476
WDR43	-1660
RPP30	-1749
RPL26L1	-1755
RPL6	-1834
RPP38	-1912
RPL35A	-1915
RPL5	-2001
MRM1	-2068
UTP15	-2083
RRP36	-2085
MTERF4	-2176
RPS4X	-2225
RPS6	-2299
UTP6	-2341
RPL11	-2374
NOL11	-2505
DIS3	-2531
RPS3A	-2553
WDR75	-2802
NOL12	-2845
MT-ATP8	-2900
RPP14	-3047
RBM28	-3115
RPS25	-3129
RPL22	-3228
THUMPD1	-3334
RPL22L1	-3463
RPP25	-3464
RPL24	-3530
MTREX	-3560
RIOK3	-3677
UTP11	-3689
DDX52	-3774
FCF1	-3920
WDR12	-4090
NOP58	-4217
EXOSC9	-4334
SENP3	-4374
PRORP	-4513
DDX21	-4531
RPS7	-4550
EXOSC8	-4755
DIMT1	-4887
TRMT10C	-5078
EXOSC3	-5079
TEX10	-5212
RPP40	-5654
RPL36A	-5827
KRR1	-5948
ERI1	-6093
C1D	-6214
WDR36	-7214
DCAF13	-7300
RPS26	-7408
UTP14C	-7565
EXOSC6	-8109
EXOSC7	-8489
PWP2	-8653

---

Developmental Biology

Developmental Biology

	289
set	Developmental Biology
setSize	726
pANOVA	1.72e-09
s.dist	0.132
p.adjustANOVA	1.01e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GDNF	7169
EGR2	7167
JUN	7163
KLF4	7151
RHOB	7145
PTGDS	7128
NCAM1	7122
MYC	7103
SOX10	7071
UBB	7069
DPYSL4	7045
HES1	7039
UBC	7001
SCN4B	6967
MYH11	6937
L1CAM	6930
PLXNB3	6926
MYOG	6925
SEMA6A	6924
WNT4	6920

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GDNF	7169
EGR2	7167
JUN	7163
KLF4	7151
RHOB	7145
PTGDS	7128
NCAM1	7122
MYC	7103
SOX10	7071
UBB	7069
DPYSL4	7045
HES1	7039
UBC	7001
SCN4B	6967
MYH11	6937
L1CAM	6930
PLXNB3	6926
MYOG	6925
SEMA6A	6924
WNT4	6920
H2BC21	6906
SEMA6D	6885
POLR2A	6867
H2AC6	6859
AJUBA	6854
CACNG8	6784
MYF6	6739
EFNB1	6731
CLTCL1	6715
PRX	6685
HSP90AB1	6626
IL6R	6618
SEMA4D	6612
MED27	6599
EZR	6592
PLXNB1	6583
SCN5A	6582
KRT7	6578
CDKN1A	6565
PSMB3	6540
PDLIM7	6536
RPSA	6533
MYO10	6528
PAK1	6509
EFNA4	6496
EPHA2	6472
PIK3R1	6465
LAMB1	6450
NR2F2	6443
NEO1	6436
SPTBN5	6428
EIF4A3	6413
PRNP	6409
DRP2	6390
TSC22D1	6376
CAPNS1	6371
RUNX1	6355
RPL36AL	6352
ZFPM2	6351
PRKCQ	6333
ITGA9	6304
COL4A3	6295
ROBO1	6242
JUP	6213
MYOD1	6176
ADIRF	6160
POLR2F	6141
MPZ	6117
EPHB3	6114
ADAM23	6075
PSMD3	6058
DOCK1	6051
HELZ2	6044
AGAP2	6022
PSMD1	5956
H2BC4	5939
PSMB5	5903
TBL1X	5900
PML	5894
PSMB8	5892
H2BC5	5864
CRMP1	5806
RPS2	5798
CSF3R	5780
ARHGAP39	5746
LIMK2	5711
CDH15	5705
MED29	5689
MED12	5688
RPLP2	5670
COL6A2	5662
SNW1	5649
MED20	5637
RPS15	5631
SMARCD3	5606
CNTNAP1	5603
RGMB	5584
PCGF2	5564
NCK2	5545
RPS11	5527
COL4A4	5522
RPS3	5509
PSMB9	5506
RPL9	5484
EIF4G1	5479
RPL19	5434
ARHGEF28	5427
SCN8A	5412
AMH	5411
PSMC3	5388
FOXD3	5383
PKP2	5345
PSMD2	5344
PSMB6	5343
MED26	5317
SEMA7A	5307
COL9A3	5305
NAB2	5292
SRC	5289
LGI4	5274
RPS9	5216
RPL18	5215
CTNNA1	5158
SLIT3	5141
RPLP1	5137
ELOB	5136
MAFB	5108
NCSTN	5091
KMT2D	5087
CTNNB1	5071
SMAD3	5059
SHANK3	5047
RPL13A	5043
MYL9	5040
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
HRAS	5006
MYH14	5004
PSMB4	4992
RPL37A	4988
CNTN1	4984
EPHB1	4950
EP300	4947
COL4A1	4943
PAGR1	4921
STAT3	4875
CLTB	4872
CEBPB	4858
RPL29	4856
RPL23A	4851
POU3F1	4832
RPS19	4757
RPL38	4753
RPS16	4751
BOC	4689
MYL6	4688
ZSWIM8	4646
TLN1	4630
CDH4	4615
ACTB	4598
RPS28	4590
COL4A2	4560
RPL28	4548
TIAM1	4542
MED16	4532
CSNK2B	4488
RPL3L	4465
MED15	4453
EFNB2	4451
H2BC11	4413
DSG2	4393
SPTBN1	4389
CEBPA	4365
RPL14	4354
RPS15A	4345
RPL37	4334
KRT19	4315
RPS6KA1	4288
RPL32	4253
LYPLA2	4242
PAK4	4228
NUMB	4213
PSMC4	4202
POLR2I	4168
ZNF335	4133
FGF10	4128
DOK1	4106
COL9A2	4103
KRT31	4085
HDAC3	4059
EED	4045
GSPT2	4044
CFL1	4031
ABLIM2	4024
PSMC5	4020
SHC1	4009
MAPK3	3978
DRAP1	3967
CACNA1H	3908
SPTAN1	3906
MAML1	3904
TGS1	3888
KDM6A	3847
RPL41	3826
RPL8	3810
ANK1	3809
ACVR1B	3805
KRT80	3803
RANBP9	3799
NFKB1	3787
MED24	3755
AP2S1	3753
RPL36	3737
ITGA10	3720
H2AJ	3710
RPLP0	3705
CAPN1	3693
PSEN2	3671
SCD5	3664
FABP4	3661
CAP2	3621
CACNA1S	3615
DLG4	3572
MAP2K1	3553
ABLIM3	3520
GPC1	3507
PLCG1	3502
LAMA2	3471
RBBP7	3453
POLR2L	3442
ACTG1	3415
FAU	3409
CTCF	3350
ARPC1A	3340
SIAH2	3333
FARP2	3315
PLXND1	3298
PSMB10	3266
MAPK13	3255
RPS5	3240
RELA	3205
SPTBN2	3157
AP2B1	3063
EFNA1	3057
HSPA8	3050
PSMB7	3031
POLR2E	3025
CREBBP	3022
PPARG	3002
RPL30	2947
CLTA	2934
CD72	2820
PSMC1	2778
RPS29	2765
THRAP3	2759
MYH9	2741
HOXD3	2737
MYF5	2735
PTPRA	2723
DNM2	2701
NCOR1	2691
AP2A2	2632
MAP2K2	2618
PIK3R2	2602
MYL12B	2573
RELN	2556
SCN4A	2539
VAV2	2529
NRP2	2515
RPS21	2509
RPL7A	2493
CACNB1	2475
RPL13	2437
PKP4	2424
MED14	2423
PSMA5	2400
SIAH1	2368
EPHA4	2324
CDK4	2274
MED8	2247
RPL12	2246
RHOC	2169
ELOC	2152
ANGPTL4	2138
PSMC2	2124
MAPK1	2069
CARM1	2068
RXRA	2060
MED6	2039
UPF2	2033
RGMA	2022
RPS13	2004
POLR2H	1965
GIT1	1958
CSNK2A1	1957
SMARCA4	1946
RARA	1941
MED11	1937
MAPK14	1922
RBX1	1898
DNM3	1873
KLF5	1870
FGFR1	1828
PSMB2	1820
SCN1B	1809
PSMB1	1804
HOXA3	1777
PSMA7	1752
CEBPD	1721
YAP1	1700
DHH	1697
ARHGEF7	1693
RPS18	1690
RPL23	1687
ASH2L	1660
RPL31	1652
SLIT1	1643
NOTCH1	1602
ERBB2	1598
MAGOH	1590
ARPC4	1580
RPL18A	1485
RPS10	1452
RPS14	1447
MEF2D	1433
RPL27	1373
ABL1	1363
RPL10	1356
CXCR4	1350
PSMD7	1338
RPS23	1326
AKT2	1313
RPS20	1305
AP2M1	1276
LDB1	1245
SPI1	1227
HOXA4	1220
TGM1	1188
SCN3B	1166
CHL1	1125
PSMD9	1114
PSMA1	1108
TCF12	1086
POLR2J	1069
RPL27A	1058
PSMD13	1057
COL6A1	1051
H2AZ1	1034
GAB2	1024
EPHB6	986
EPAS1	976
PRKACA	933
PITPNA	878
SLIT2	875
MEF2C	862
CAP1	849
ANK2	813
PSMD6	790
NCOA3	743
NCK1	742
POLR2B	739
PSMF1	734
CSNK2A2	726
VAV3	716
EBF1	696
CASC3	674
PFN1	627
PSME1	622
MET	567
NRP1	566
CACNA1C	525
RPL4	516
RPL15	466
ACVR2B	454
KAZN	442
RPL35	420
RPS12	414
RPL34	379
POLR2G	336
RPS27	304
RPL39	225
ANK3	216
RPL3	207
NCOA1	161
RPS27L	146
RNPS1	144
CDK19	124
ITSN1	78
WWTR1	71
PIK3CD	66
EGFR	24
AP2A1	2
RPL7	-2
NFASC	-15
SREBF2	-50
PSMA2	-124
MBP	-149
RPS27A	-177
MED17	-196
MED18	-277
SREBF1	-288
PLXNA4	-291
EPHB4	-294
MED22	-298
POLR2C	-311
RPL26	-335
CLTC	-338
HHEX	-361
RHOA	-387
CLASP1	-395
PSMA6	-423
PLXNA3	-440
VASP	-447
APH1A	-462
PLXNC1	-471
FURIN	-473
FAM120B	-488
MSN	-527
SPTBN4	-529
KALRN	-547
RPL10A	-551
RPS17	-616
RBBP4	-634
RAC1	-651
RPL17	-661
PSMD11	-674
MMP2	-682
NR6A1	-759
CDK5	-764
GRB2	-787
SRGAP1	-791
PSMD5	-792
SOS2	-819
RPS24	-856
ADAM22	-893
COL6A3	-900
E2F1	-916
MAPK11	-930
PTK2	-936
PPP3CB	-967
PAXIP1	-988
TFDP1	-989
MEF2A	-1034
RBM8A	-1037
FGF9	-1079
RPS8	-1110
MED23	-1140
POLR2D	-1176
PFN2	-1187
APH1B	-1232
SLC2A4	-1234
COL4A5	-1242
ARHGEF11	-1247
NCBP2	-1265
DOK4	-1300
RPS4Y1	-1305
MAP2K6	-1310
MAML3	-1311
GATA2	-1327
H2BC15	-1351
SEM1	-1355
LIMK1	-1361
PTPRC	-1414
TCF3	-1438
PSMD14	-1462
RPL21	-1476
NGEF	-1495
NCOA6	-1537
RPS6KA4	-1568
EVL	-1571
H2BC12	-1620
PBX1	-1645
PSME3	-1684
HOXD4	-1746
RPL26L1	-1755
RET	-1761
KAT2A	-1777
MAPK12	-1789
UPF3B	-1799
TYROBP	-1801
EPHA3	-1820
RPL6	-1834
LAMC1	-1835
MED1	-1907
RPL35A	-1915
DAG1	-1926
PLXNA1	-1965
PLXNA2	-1984
RPL5	-2001
PLIN1	-2011
RDX	-2017
MEIS1	-2026
CREB1	-2036
PSMC6	-2073
MYO9B	-2121
ACVR2A	-2137
PSMA4	-2141
RPS6KA2	-2146
ADGRG6	-2164
CACNB3	-2194
RPS4X	-2225
HDAC2	-2256
RPS6	-2299
DPYSL3	-2325
AGRN	-2334
PKNOX1	-2356
RPL11	-2374
PERP	-2405
UPF3A	-2450
CYP51A1	-2451
KAT2B	-2462
RARG	-2475
RPS3A	-2553
WDR5	-2564
ADGRV1	-2585
RPS6KA6	-2599
SRGAP2	-2601
MYH10	-2642
RRAS	-2656
SMAD4	-2667
PSEN1	-2856
NCOR2	-2980
DLG3	-2993
GSPT1	-2996
ARPC5	-3020
RPS6KA5	-3028
HOXB4	-3127
RPS25	-3129
NAB1	-3224
RPL22	-3228
SMAD2	-3242
SUZ12	-3267
POLR2K	-3290
PRKAR2A	-3291
ZNF638	-3367
YY1	-3370
RASA1	-3386
KMT2C	-3442
SPAG9	-3443
RPL22L1	-3463
PSENEN	-3511
STX1A	-3526
RPL24	-3530
CLASP2	-3540
MED4	-3599
ETF1	-3636
PSMA3	-3674
TCF4	-3708
UNC5B	-3775
SEMA5A	-3788
EZH2	-3818
DLG1	-3888
SPTB	-3910
FOXO1	-3949
HSP90AA1	-4069
MAFA	-4100
HOXB2	-4114
SPTA1	-4170
CDK5R1	-4220
CDK8	-4232
PIAS2	-4280
CCND3	-4286
NCBP1	-4287
RBBP5	-4289
ACVR1C	-4295
PSMD10	-4314
HIF3A	-4319
MAPK7	-4332
MMP9	-4336
ABL2	-4397
ST8SIA4	-4403
PSMD12	-4430
FYN	-4434
SEMA4A	-4440
FLI1	-4448
PABPC1	-4540
BNIP2	-4546
RPS7	-4550
GAB1	-4602
TGFB1	-4611
ADIPOQ	-4638
SCN9A	-4688
SHTN1	-4738
NRAS	-4823
MED21	-4836
CDK2	-4871
CXCL12	-4878
MAGOHB	-4885
FES	-4901
TRPC1	-4906
ACTR3	-4907
LYN	-4973
DOK2	-5034
LGI1	-5037
ARHGAP35	-5059
AKT1	-5072
MAML2	-5100
PAK6	-5101
ARPC2	-5121
CUL2	-5250
PTPN11	-5259
GDF1	-5260
VLDLR	-5264
MED19	-5289
ARPC1B	-5365
WASL	-5406
PIK3CA	-5439
NTN4	-5462
FRS2	-5466
DOK5	-5469
MYL12A	-5471
ZNF467	-5555
PKP1	-5556
FGF2	-5582
MED28	-5583
PAK2	-5599
CD36	-5611
SRGAP3	-5625
ACTR2	-5629
FOXO3	-5645
ROCK2	-5656
UTRN	-5659
MAPK8	-5685
HOXB3	-5689
MED31	-5698
KRT10	-5743
ITGB1	-5747
LPL	-5765
TRIO	-5777
RPL36A	-5827
TFDP2	-5832
ENAH	-5841
MED30	-5908
CDC42	-5909
ITGA2	-5944
MED10	-5989
GRB10	-6014
RARB	-6057
MED25	-6062
GFRA2	-6088
ITGA1	-6109
MED9	-6141
PSME4	-6160
ROBO3	-6170
SDCBP	-6188
GSK3B	-6221
SCN7A	-6224
FLRT3	-6285
ITGA2B	-6287
ADAM10	-6298
KMT2A	-6316
SOS1	-6323
NODAL	-6325
PIP5K1C	-6386
USP33	-6398
HMGCR	-6428
RPS6KA3	-6448
H2AZ2	-6464
MAMLD1	-6509
PRKCA	-6547
H3-3A	-6551
MED13L	-6564
CNOT6	-6644
PIK3CB	-6671
PAK3	-6715
MED7	-6868
LHX4	-6874
ITGA5	-6957
MED13	-6973
PIK3R3	-6979
ALCAM	-7006
PPL	-7019
ARPC3	-7025
GFRA1	-7041
MEF2B	-7060
CD24	-7128
AKT3	-7181
SH3KBP1	-7233
ROCK1	-7237
DEK	-7255
SEMA3A	-7306
SHC3	-7397
RPS26	-7408
CEBPE	-7409
LGI2	-7434
CDON	-7472
DPYSL2	-7489
YES1	-7544
CHD9	-7626
SCN2B	-7697
CSTA	-7766
CBFB	-7768
SCN3A	-7776
EFNA5	-7796
SDC2	-7832
ITGAV	-7838
NELL2	-7844
PRKACB	-7886
KRAS	-7901
NTN1	-7919
ARHGEF12	-7956
GSC	-7970
PCSK6	-8006
CCNC	-8026
LEP	-8059
FOXP1	-8084
PMP22	-8110
NCOA2	-8186
RBPJ	-8202
TBL1XR1	-8260
COL6A6	-8270
GFI1	-8273
TEAD1	-8405
H2AC18	-8408
PPARA	-8477
CACNB2	-8478
ABLIM1	-8483
SOX9	-8540
TAL1	-8588
WNT10B	-8613
PPARGC1A	-8632
ITGB3	-8655
IRS2	-8696
DNM1	-8699

---

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs

	1009
set	Regulation of expression of SLITs and ROBOs
setSize	160
pANOVA	2.48e-09
s.dist	0.273
p.adjustANOVA	1.4e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBB	7069
UBC	7001
PSMB3	6540
RPSA	6533
EIF4A3	6413
RPL36AL	6352
ROBO1	6242
PSMD3	6058
PSMD1	5956
PSMB5	5903
PSMB8	5892
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
PSMB9	5506
RPL9	5484
EIF4G1	5479
RPL19	5434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBB	7069
UBC	7001
PSMB3	6540
RPSA	6533
EIF4A3	6413
RPL36AL	6352
ROBO1	6242
PSMD3	6058
PSMD1	5956
PSMB5	5903
PSMB8	5892
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
PSMB9	5506
RPL9	5484
EIF4G1	5479
RPL19	5434
PSMC3	5388
PSMD2	5344
PSMB6	5343
RPS9	5216
RPL18	5215
RPLP1	5137
ELOB	5136
RPL13A	5043
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
PSMB4	4992
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
ZSWIM8	4646
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
PSMC4	4202
GSPT2	4044
PSMC5	4020
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
FAU	3409
PSMB10	3266
RPS5	3240
PSMB7	3031
RPL30	2947
PSMC1	2778
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
PSMA5	2400
RPL12	2246
ELOC	2152
PSMC2	2124
UPF2	2033
RPS13	2004
RBX1	1898
PSMB2	1820
PSMB1	1804
PSMA7	1752
RPS18	1690
RPL23	1687
RPL31	1652
SLIT1	1643
MAGOH	1590
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
PSMD7	1338
RPS23	1326
RPS20	1305
LDB1	1245
PSMD9	1114
PSMA1	1108
RPL27A	1058
PSMD13	1057
SLIT2	875
PSMD6	790
PSMF1	734
CASC3	674
PSME1	622
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RNPS1	144
RPL7	-2
PSMA2	-124
RPS27A	-177
RPL26	-335
PSMA6	-423
RPL10A	-551
RPS17	-616
RPL17	-661
PSMD11	-674
PSMD5	-792
RPS24	-856
RBM8A	-1037
RPS8	-1110
COL4A5	-1242
NCBP2	-1265
RPS4Y1	-1305
SEM1	-1355
PSMD14	-1462
RPL21	-1476
PSME3	-1684
RPL26L1	-1755
UPF3B	-1799
RPL6	-1834
RPL35A	-1915
DAG1	-1926
RPL5	-2001
PSMC6	-2073
PSMA4	-2141
RPS4X	-2225
RPS6	-2299
RPL11	-2374
UPF3A	-2450
RPS3A	-2553
GSPT1	-2996
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
ETF1	-3636
PSMA3	-3674
NCBP1	-4287
PSMD10	-4314
PSMD12	-4430
PABPC1	-4540
RPS7	-4550
MAGOHB	-4885
CUL2	-5250
RPL36A	-5827
PSME4	-6160
ROBO3	-6170
USP33	-6398
LHX4	-6874
RPS26	-7408

---

Fcgamma receptor (FCGR) dependent phagocytosis

Fcgamma receptor (FCGR) dependent phagocytosis

	393
set	Fcgamma receptor (FCGR) dependent phagocytosis
setSize	126
pANOVA	8.84e-09
s.dist	-0.297
p.adjustANOVA	4.8e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
MYO5A	-7688
YES1	-7544
IGLV2-11	-7331
SYK	-7265
IGKV1-12	-7141
ARPC3	-7025
FCGR2A	-6859
ITPR2	-6797
BTK	-6686
CRK	-6681
PIK3CB	-6671
FGR	-6559
CDC42	-5909
NCKAP1	-5855
ACTR2	-5629
PRKCD	-5561
PIK3CA	-5439
WASL	-5406
ARPC1B	-5365
IGLV6-57	-5247
BAIAP2	-5202
ARPC2	-5121
PLD1	-5056
LYN	-4973
ACTR3	-4907
ITPR1	-4601
IGKC	-4532
ABI2	-4465
FYN	-4434
HSP90AA1	-4069
WIPF2	-3984
WASF1	-3856
WAS	-3848
WIPF3	-3685
ARPC5	-3020
IGHV3-23	-2920
NCKAP1L	-2883
WASF2	-2881
MYO9B	-2121
MYH2	-1745
PRKCE	-1533
LIMK1	-1361
PTK2	-936
VAV1	-788
GRB2	-787
RAC1	-651
FCGR3A	-536
CYFIP2	-73
ABI1	-27
PLCG2	133
PLPP5	498
WIPF1	510
BRK1	573
VAV3	716
NCK1	742
WASF3	945
PLA2G6	1040
ABL1	1363
ARPC4	1580
HCK	1982
MAPK1	2069
VAV2	2529
PIK3R2	2602
MYH9	2741
MYO1C	3202
NF2	3220
ARPC1A	3340
ACTG1	3415
PLCG1	3502
NCKIPSD	3524
MAPK3	3978
CFL1	4031
ELMO1	4078
ITPR3	4090
ACTB	4598
CYFIP1	4618
CD247	4704
PLD3	5072
SRC	5289
IGKV1-33	5604
PLD2	5712
DOCK1	6051
ELMO2	6350
PIK3R1	6465
PAK1	6509
MYO10	6528
HSP90AB1	6626
AHCYL1	6766

---

Nervous system development

Nervous system development

	734
set	Nervous system development
setSize	479
pANOVA	1.27e-08
s.dist	0.152
p.adjustANOVA	6.65e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GDNF	7169
EGR2	7167
RHOB	7145
NCAM1	7122
SOX10	7071
UBB	7069
DPYSL4	7045
UBC	7001
SCN4B	6967
MYH11	6937
L1CAM	6930
PLXNB3	6926
SEMA6A	6924
SEMA6D	6885
EFNB1	6731
CLTCL1	6715
PRX	6685
HSP90AB1	6626
SEMA4D	6612
EZR	6592

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GDNF	7169
EGR2	7167
RHOB	7145
NCAM1	7122
SOX10	7071
UBB	7069
DPYSL4	7045
UBC	7001
SCN4B	6967
MYH11	6937
L1CAM	6930
PLXNB3	6926
SEMA6A	6924
SEMA6D	6885
EFNB1	6731
CLTCL1	6715
PRX	6685
HSP90AB1	6626
SEMA4D	6612
EZR	6592
PLXNB1	6583
SCN5A	6582
PSMB3	6540
PDLIM7	6536
RPSA	6533
MYO10	6528
PAK1	6509
EFNA4	6496
EPHA2	6472
PIK3R1	6465
LAMB1	6450
NEO1	6436
SPTBN5	6428
EIF4A3	6413
PRNP	6409
DRP2	6390
RPL36AL	6352
PRKCQ	6333
ITGA9	6304
COL4A3	6295
ROBO1	6242
MPZ	6117
EPHB3	6114
PSMD3	6058
DOCK1	6051
AGAP2	6022
PSMD1	5956
PSMB5	5903
PSMB8	5892
CRMP1	5806
RPS2	5798
ARHGAP39	5746
LIMK2	5711
RPLP2	5670
COL6A2	5662
RPS15	5631
CNTNAP1	5603
RGMB	5584
NCK2	5545
RPS11	5527
COL4A4	5522
RPS3	5509
PSMB9	5506
RPL9	5484
EIF4G1	5479
RPL19	5434
ARHGEF28	5427
SCN8A	5412
PSMC3	5388
PSMD2	5344
PSMB6	5343
SEMA7A	5307
COL9A3	5305
NAB2	5292
SRC	5289
RPS9	5216
RPL18	5215
SLIT3	5141
RPLP1	5137
ELOB	5136
NCSTN	5091
SHANK3	5047
RPL13A	5043
MYL9	5040
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
HRAS	5006
MYH14	5004
PSMB4	4992
RPL37A	4988
CNTN1	4984
EPHB1	4950
COL4A1	4943
CLTB	4872
RPL29	4856
RPL23A	4851
POU3F1	4832
RPS19	4757
RPL38	4753
RPS16	4751
MYL6	4688
ZSWIM8	4646
TLN1	4630
ACTB	4598
RPS28	4590
COL4A2	4560
RPL28	4548
TIAM1	4542
CSNK2B	4488
RPL3L	4465
EFNB2	4451
SPTBN1	4389
RPL14	4354
RPS15A	4345
RPL37	4334
RPS6KA1	4288
RPL32	4253
LYPLA2	4242
PAK4	4228
NUMB	4213
PSMC4	4202
DOK1	4106
COL9A2	4103
GSPT2	4044
CFL1	4031
ABLIM2	4024
PSMC5	4020
SHC1	4009
MAPK3	3978
CACNA1H	3908
SPTAN1	3906
RPL41	3826
RPL8	3810
ANK1	3809
RANBP9	3799
AP2S1	3753
RPL36	3737
ITGA10	3720
RPLP0	3705
PSEN2	3671
SCD5	3664
CAP2	3621
CACNA1S	3615
DLG4	3572
MAP2K1	3553
ABLIM3	3520
GPC1	3507
PLCG1	3502
LAMA2	3471
ACTG1	3415
FAU	3409
ARPC1A	3340
SIAH2	3333
FARP2	3315
PLXND1	3298
PSMB10	3266
MAPK13	3255
RPS5	3240
SPTBN2	3157
AP2B1	3063
EFNA1	3057
HSPA8	3050
PSMB7	3031
RPL30	2947
CLTA	2934
CD72	2820
PSMC1	2778
RPS29	2765
MYH9	2741
PTPRA	2723
DNM2	2701
AP2A2	2632
MAP2K2	2618
PIK3R2	2602
MYL12B	2573
RELN	2556
SCN4A	2539
VAV2	2529
NRP2	2515
RPS21	2509
RPL7A	2493
CACNB1	2475
RPL13	2437
PSMA5	2400
SIAH1	2368
EPHA4	2324
RPL12	2246
RHOC	2169
ELOC	2152
PSMC2	2124
MAPK1	2069
UPF2	2033
RGMA	2022
RPS13	2004
GIT1	1958
CSNK2A1	1957
SMARCA4	1946
MAPK14	1922
RBX1	1898
DNM3	1873
FGFR1	1828
PSMB2	1820
SCN1B	1809
PSMB1	1804
PSMA7	1752
YAP1	1700
ARHGEF7	1693
RPS18	1690
RPL23	1687
RPL31	1652
SLIT1	1643
ERBB2	1598
MAGOH	1590
ARPC4	1580
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
ABL1	1363
RPL10	1356
CXCR4	1350
PSMD7	1338
RPS23	1326
RPS20	1305
AP2M1	1276
LDB1	1245
SCN3B	1166
CHL1	1125
PSMD9	1114
PSMA1	1108
RPL27A	1058
PSMD13	1057
COL6A1	1051
GAB2	1024
EPHB6	986
PRKACA	933
PITPNA	878
SLIT2	875
CAP1	849
ANK2	813
PSMD6	790
NCK1	742
PSMF1	734
CSNK2A2	726
VAV3	716
CASC3	674
PFN1	627
PSME1	622
MET	567
NRP1	566
CACNA1C	525
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
ANK3	216
RPL3	207
RPS27L	146
RNPS1	144
ITSN1	78
WWTR1	71
PIK3CD	66
EGFR	24
AP2A1	2
RPL7	-2
NFASC	-15
SREBF2	-50
PSMA2	-124
MBP	-149
RPS27A	-177
PLXNA4	-291
EPHB4	-294
RPL26	-335
CLTC	-338
RHOA	-387
CLASP1	-395
PSMA6	-423
PLXNA3	-440
VASP	-447
APH1A	-462
PLXNC1	-471
MSN	-527
SPTBN4	-529
KALRN	-547
RPL10A	-551
RPS17	-616
RAC1	-651
RPL17	-661
PSMD11	-674
MMP2	-682
CDK5	-764
GRB2	-787
SRGAP1	-791
PSMD5	-792
SOS2	-819
RPS24	-856
COL6A3	-900
MAPK11	-930
PTK2	-936
PPP3CB	-967
RBM8A	-1037
RPS8	-1110
PFN2	-1187
APH1B	-1232
COL4A5	-1242
ARHGEF11	-1247
NCBP2	-1265
DOK4	-1300
RPS4Y1	-1305
SEM1	-1355
LIMK1	-1361
PTPRC	-1414
PSMD14	-1462
RPL21	-1476
NGEF	-1495
RPS6KA4	-1568
EVL	-1571
PSME3	-1684
RPL26L1	-1755
RET	-1761
MAPK12	-1789
UPF3B	-1799
TYROBP	-1801
EPHA3	-1820
RPL6	-1834
LAMC1	-1835
RPL35A	-1915
DAG1	-1926
PLXNA1	-1965
PLXNA2	-1984
RPL5	-2001
RDX	-2017
CREB1	-2036
PSMC6	-2073
MYO9B	-2121
PSMA4	-2141
RPS6KA2	-2146
ADGRG6	-2164
CACNB3	-2194
RPS4X	-2225
HDAC2	-2256
RPS6	-2299
DPYSL3	-2325
AGRN	-2334
RPL11	-2374
UPF3A	-2450
CYP51A1	-2451
RPS3A	-2553
ADGRV1	-2585
RPS6KA6	-2599
SRGAP2	-2601
MYH10	-2642
RRAS	-2656
PSEN1	-2856
DLG3	-2993
GSPT1	-2996
ARPC5	-3020
RPS6KA5	-3028
RPS25	-3129
NAB1	-3224
RPL22	-3228
PRKAR2A	-3291
RASA1	-3386
RPL22L1	-3463
PSENEN	-3511
RPL24	-3530
CLASP2	-3540
ETF1	-3636
PSMA3	-3674
UNC5B	-3775
SEMA5A	-3788
DLG1	-3888
SPTB	-3910
HSP90AA1	-4069
SPTA1	-4170
CDK5R1	-4220
NCBP1	-4287
PSMD10	-4314
MAPK7	-4332
MMP9	-4336
ABL2	-4397
ST8SIA4	-4403
PSMD12	-4430
FYN	-4434
SEMA4A	-4440
PABPC1	-4540
RPS7	-4550
GAB1	-4602
SCN9A	-4688
SHTN1	-4738
NRAS	-4823
CXCL12	-4878
MAGOHB	-4885
FES	-4901
TRPC1	-4906
ACTR3	-4907
LYN	-4973
DOK2	-5034
ARHGAP35	-5059
PAK6	-5101
ARPC2	-5121
CUL2	-5250
PTPN11	-5259
VLDLR	-5264
ARPC1B	-5365
WASL	-5406
PIK3CA	-5439
NTN4	-5462
FRS2	-5466
DOK5	-5469
MYL12A	-5471
PAK2	-5599
SRGAP3	-5625
ACTR2	-5629
ROCK2	-5656
UTRN	-5659
MAPK8	-5685
ITGB1	-5747
TRIO	-5777
RPL36A	-5827
ENAH	-5841
CDC42	-5909
ITGA2	-5944
GRB10	-6014
GFRA2	-6088
ITGA1	-6109
PSME4	-6160
ROBO3	-6170
SDCBP	-6188
GSK3B	-6221
SCN7A	-6224
FLRT3	-6285
ITGA2B	-6287
ADAM10	-6298
SOS1	-6323
PIP5K1C	-6386
USP33	-6398
HMGCR	-6428
RPS6KA3	-6448
PRKCA	-6547
PIK3CB	-6671
PAK3	-6715
LHX4	-6874
ITGA5	-6957
PIK3R3	-6979
ALCAM	-7006
ARPC3	-7025
GFRA1	-7041
CD24	-7128
SH3KBP1	-7233
ROCK1	-7237
SEMA3A	-7306
SHC3	-7397
RPS26	-7408
DPYSL2	-7489
YES1	-7544
SCN2B	-7697
SCN3A	-7776
EFNA5	-7796
SDC2	-7832
ITGAV	-7838
NELL2	-7844
PRKACB	-7886
KRAS	-7901
NTN1	-7919
ARHGEF12	-7956
PMP22	-8110
COL6A6	-8270
TEAD1	-8405
CACNB2	-8478
ABLIM1	-8483
ITGB3	-8655
IRS2	-8696
DNM1	-8699

---

Cellular responses to stimuli

Cellular responses to stimuli

	173
set	Cellular responses to stimuli
setSize	663
pANOVA	2.43e-08
s.dist	0.128
p.adjustANOVA	1.23e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL6	7168
ATF3	7166
FOS	7164
JUN	7163
CHAC1	7161
TXNIP	7148
HSPA1B	7087
PPP1R15A	7073
UBB	7069
HSPA1A	7054
ETS2	7048
CITED2	7010
STAP2	7003
UBC	7001
VCP	6958
UBE2C	6931
IGFBP7	6918
H2BC21	6906
H1-0	6871
H2AC6	6859

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL6	7168
ATF3	7166
FOS	7164
JUN	7163
CHAC1	7161
TXNIP	7148
HSPA1B	7087
PPP1R15A	7073
UBB	7069
HSPA1A	7054
ETS2	7048
CITED2	7010
STAP2	7003
UBC	7001
VCP	6958
UBE2C	6931
IGFBP7	6918
H2BC21	6906
H1-0	6871
H2AC6	6859
AJUBA	6854
CCL2	6830
NPRL2	6758
HSPB8	6753
SRPRA	6752
TSPYL2	6749
STIP1	6741
SESN2	6723
HMOX1	6629
HSP90AB1	6626
HSPA12A	6621
CDKN1A	6565
PSMB3	6540
RPSA	6533
DCTN1	6446
BAG3	6393
DYNC1H1	6386
ARNTL	6375
RPL36AL	6352
KAT5	6332
MT-CO2	6275
CRYAB	6273
NFYC	6212
MT2A	6149
ATF4	6122
PARN	6097
WFS1	6071
PSMD3	6058
HELZ2	6044
WDR59	5993
PSMD1	5956
PHC1	5949
H2BC4	5939
MT-CO1	5923
PSMB5	5903
TBL1X	5900
PSMB8	5892
DDX11	5875
H2BC5	5864
PRDX2	5812
RPS2	5798
TERF2IP	5763
SERPINH1	5727
CREB3L1	5723
RING1	5704
DNAJB1	5684
RPLP2	5670
RPS15	5631
TP53	5630
RRAGA	5620
SMARCD3	5606
CBX4	5597
ANAPC1	5585
MT1M	5580
NUP62	5560
ANAPC2	5558
RPS11	5527
GPX1	5525
RPS3	5509
PSMB9	5506
ATF5	5488
RPL9	5484
ARNT	5445
RPL19	5434
HSPA1L	5431
PSMC3	5388
ATP6V0D1	5382
CRTC1	5369
PSMD2	5344
PSMB6	5343
PRDX6	5327
SLC46A1	5304
RPS9	5216
RPL18	5215
CXXC1	5189
RPLP1	5137
ELOB	5136
NUP88	5134
RPL13A	5043
TATDN2	5042
CCAR2	5041
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
PSMB4	4992
RPL37A	4988
EP300	4947
NUP188	4942
CBX8	4933
ERN1	4905
NUP98	4904
ATP6V1F	4877
STAT3	4875
HDAC6	4866
ACTR1A	4862
CEBPB	4858
RPL29	4856
RPL23A	4851
ANAPC7	4844
LMNA	4817
YWHAE	4776
NUP160	4771
PRDX1	4767
RPS19	4757
PRDX5	4756
RPL38	4753
RPS16	4751
CREB3L4	4739
CCS	4709
TLN1	4630
COX6B1	4619
RPS28	4590
SCMH1	4589
DCTN3	4584
ATP6V0E2	4569
EXOSC5	4553
RPL28	4548
TXNRD1	4516
CDC23	4497
CSNK2B	4488
SEC31A	4486
RPL3L	4465
GCN1	4436
H2BC11	4413
CAT	4378
SEC13	4359
RPL14	4354
RPS15A	4345
DCTN2	4336
RPL37	4334
RPS6KA1	4288
CUL7	4257
RPL32	4253
CREB3L2	4230
ATP6V1H	4217
HIRA	4204
PSMC4	4202
GSTP1	4174
FZR1	4121
TPR	4113
TACO1	4069
ATP6V1B2	4064
DYNLL1	4061
HDAC3	4059
EED	4045
POM121	4042
TXNRD2	4025
PSMC5	4020
COL4A6	4019
SHC1	4009
SIN3A	4005
MAPK3	3978
COX8A	3970
CDC26	3948
COX19	3911
TGS1	3888
TNRC6C	3884
HSPA2	3849
CSRP1	3829
RPL41	3826
COX5B	3824
CAMK2B	3811
RPL8	3810
KEAP1	3790
NFKB1	3787
RPTOR	3785
ZBTB17	3743
RPL36	3737
CUL1	3712
H2AJ	3710
RPLP0	3705
NUP205	3685
SIN3B	3670
DEDD2	3636
ANAPC11	3622
EXOSC4	3577
ADD1	3533
RBBP7	3453
TINF2	3430
NFE2L2	3429
FAU	3409
MAPKAPK3	3401
LAMTOR2	3386
NPRL3	3383
ITFG2	3375
SRPRB	3352
RPA2	3310
HIF1AN	3275
PSMB10	3266
ANAPC5	3252
ID1	3245
RPS5	3240
RELA	3205
UBN1	3185
RNF2	3130
DNAJC7	3125
ARFGAP1	3122
HSPA12B	3116
CRTC3	3093
GPX7	3079
HSPA8	3050
PSMB7	3031
CREBBP	3022
FKBP4	2985
ATP6V1E2	2976
CBX6	2966
POM121C	2955
RPL30	2947
DEPDC5	2925
P4HB	2798
ABCC1	2780
PSMC1	2778
RPS29	2765
EHMT1	2699
HSPA9	2694
NCOR1	2691
DNAJA1	2659
H1-2	2631
CRTC2	2608
GSK3A	2599
SZT2	2589
LAMTOR4	2564
CAPZA1	2555
TXN2	2550
MOV10	2537
RPS21	2509
RPL7A	2493
CTDSP2	2492
SYVN1	2466
DDIT3	2455
RPL13	2437
HSPA4	2433
WDR24	2431
NUP93	2426
ATP6V1C2	2406
PSMA5	2400
ATP6V1E1	2399
HM13	2395
DCTN4	2382
PHC2	2304
ANAPC15	2292
CDK4	2274
RPL12	2246
ST13	2233
DYNC1I2	2194
ELOC	2152
PSMC2	2124
AKT1S1	2082
MAPK1	2069
CARM1	2068
RXRA	2060
LAMTOR5	2057
RPS13	2004
SOD3	2000
GOSR2	1975
CSNK2A1	1957
MAP2K4	1951
YIF1A	1927
MAPK14	1922
RBX1	1898
PSMB2	1820
PSMB1	1804
NUP155	1758
PSMA7	1752
CAPZB	1720
MAPK10	1695
RPS18	1690
RPL23	1687
RPL31	1652
ERF	1618
ATP6V0C	1569
UBE2S	1566
PDIA5	1552
NUP133	1546
RPL18A	1485
AR	1478
KHSRP	1456
RPS10	1452
RPS14	1447
MEF2D	1433
PREB	1403
WTIP	1391
RPL27	1373
EXOSC1	1359
RPL10	1356
PSMD7	1338
RPS23	1326
RPS20	1305
ACD	1252
EHMT2	1244
NUP214	1222
CALR	1213
BLVRB	1207
RAE1	1163
MIOS	1158
NUP85	1136
HSPA6	1132
PSMD9	1114
PSMA1	1108
HERPUD1	1066
RPL27A	1058
PSMD13	1057
EXOSC2	1035
H2AZ1	1034
SOD1	982
EPAS1	976
KLHDC3	888
MEF2C	862
KDM6B	807
PSMD6	790
ATP6V1A	775
TERF2	747
PSMF1	734
CSNK2A2	726
HSPA5	645
NR1D1	639
PSME1	622
GSR	598
KPTN	577
MT-CO3	542
RPL4	516
CREB3	500
BLVRA	489
RPL15	466
MAP2K7	432
CDKN1B	428
RPL35	420
RPS12	414
PPP2R5B	402
CBX2	390
RPL34	379
MLST8	349
CAMK2G	347
RPS27	304
TNRC6A	303
ETS1	239
RPL39	225
NPAS2	212
RPL3	207
MINK1	174
NCOA1	161
UBE2E1	155
RPS27L	146
HSF1	129
NR3C2	94
NUP153	90
MYDGF	83
COX7C	42
RPL7	-2
COX4I1	-12
RPA1	-65
SKP1	-111
PSMA2	-124
RPS27A	-177
ACADVL	-178
DNAJB6	-208
SEH1L	-247
BMI1	-268
RPL26	-335
NUP35	-363
DYNC1I1	-408
EGLN2	-420
PSMA6	-423
MAP4K4	-458
SURF1	-472
AGO1	-509
RPL10A	-551
CEBPG	-591
MT1X	-603
MAPK9	-611
RPS17	-616
RPS19BP1	-632
RBBP4	-634
CDC16	-654
HMGA1	-659
RPL17	-661
HMOX2	-672
PSMD11	-674
NCF2	-687
COX14	-774
PSMD5	-792
MBTPS1	-818
RPS24	-856
NFYA	-887
ATP6V1C1	-904
E2F1	-916
ATF2	-922
MAPK11	-930
XBP1	-935
EIF2AK1	-966
TFDP1	-989
HSPH1	-999
PGR	-1028
HIKESHI	-1031
DCTN5	-1040
AAAS	-1069
RPS8	-1110
CABIN1	-1113
NDUFA4	-1120
FBXL17	-1225
RPA3	-1236
RPS4Y1	-1305
MAP2K6	-1310
H2BC15	-1351
SEM1	-1355
SERP1	-1358
NUP107	-1364
DCTN6	-1395
PSMD14	-1462
RPL21	-1476
EIF2AK4	-1478
NCOA6	-1537
CUL3	-1558
H2BC12	-1620
MRPL18	-1646
DYNLL2	-1679
PSME3	-1684
EIF2S2	-1692
EEF1A1	-1696
ATOX1	-1727
RPL26L1	-1755
LAMTOR1	-1804
NUP42	-1817
MTOR	-1833
RPL6	-1834
EXTL1	-1857
ATP6V0E1	-1867
MED1	-1907
RPL35A	-1915
SULT1A3	-1939
COX6C	-1988
RPL5	-2001
DYNC1LI1	-2020
MTF1	-2025
CREB1	-2036
PSMC6	-2073
NUP50	-2132
CCNA2	-2135
PSMA4	-2141
RPS6KA2	-2146
NOX5	-2218
RPS4X	-2225
TNRC6B	-2247
UBE2D2	-2273
RPS6	-2299
COX5A	-2355
COX7B	-2369
RPL11	-2374
CYBA	-2381
SKP2	-2390
SCO2	-2485
DIS3	-2531
RPS3A	-2553
HYOU1	-2566
VHL	-2576
PRDX3	-2589
LY96	-2597
EXTL2	-2616
E2F3	-2620
EIF2S3	-2635
MDM2	-2814
MAFK	-2828
LRPPRC	-2953
NCOR2	-2980
MAPKAPK2	-3012
RPS25	-3129
COX6A1	-3146
FLCN	-3172
RPL22	-3228
SUZ12	-3267
CDKN2B	-3350
E2F2	-3359
TCIRG1	-3382
ATP6V0B	-3410
BACH1	-3446
RPL22L1	-3463
CAMK2D	-3485
RPL24	-3530
DYNC1LI2	-3547
CCNE1	-3589
BAG5	-3612
NUP43	-3666
PSMA3	-3674
HSBP1	-3691
EZH2	-3818
HSPA7	-4032
ACTR10	-4045
HSP90AA1	-4069
EXTL3	-4083
RAI1	-4103
ATP6V1D	-4106
GFPT1	-4146
DCP2	-4168
EIF2S1	-4256
ASF1A	-4277
COX11	-4278
TPP1	-4310
PSMD10	-4314
HIF3A	-4319
HDGF	-4320
MAPK7	-4332
EXOSC9	-4334
TNIK	-4337
HSPA14	-4361
NBN	-4368
AGO4	-4407
ATP6V1G1	-4422
PSMD12	-4430
CDKN2D	-4473
SIRT1	-4509
NUP54	-4512
NRIP1	-4523
RPS7	-4550
SSR1	-4595
SP1	-4631
TNFRSF21	-4674
VEGFA	-4711
EXOSC8	-4755
RRAGB	-4796
SOD2	-4808
CDK2	-4871
KDELR3	-4960
TERF1	-5006
DNAJA2	-5051
COX20	-5054
NUP37	-5077
EXOSC3	-5079
SCO1	-5171
NUP210	-5199
COX16	-5203
CUL2	-5250
RB1	-5310
ATF6	-5311
FKBP5	-5338
PDIA6	-5343
NCF1	-5347
NUP58	-5351
HSPA4L	-5367
ATP6V1G2	-5405
FKBP14	-5413
XPO1	-5416
LAMTOR3	-5422
UBE2D3	-5531
CDC27	-5554
PRKCD	-5561
CDK6	-5574
NR3C1	-5578
SLC38A9	-5579
PLA2G4B	-5651
MAPK8	-5685
NFYB	-5690
SH3BP4	-5753
BAG1	-5782
MAPKAPK5	-5789
RPL36A	-5827
HIF1A	-5830
TFDP2	-5832
BAG2	-5879
TXN	-5883
IMPACT	-5966
BMT2	-5975
GRB10	-6014
MAP3K5	-6097
CAPZA2	-6125
PSME4	-6160
DNAJC3	-6166
BAG4	-6204
ERO1A	-6206
GSK3B	-6221
CAMK2A	-6259
RANBP2	-6291
COX7A2L	-6342
TRIB3	-6402
RPS6KA3	-6448
SESN1	-6453
H2AZ2	-6464
HSP90B1	-6513
H3-3A	-6551
HBA1	-6577
CYCS	-6623
HIGD1A	-6635
MBTPS2	-6667
RORA	-6674
ANAPC10	-6689
EIF2AK3	-6696
COX18	-6706
HBB	-6775
WIPI1	-6873
MDM4	-6890
ATP7A	-6928
MRE11	-6945
RAD50	-7036
ANAPC4	-7047
NDC1	-7051
DNAJC2	-7079
NCF4	-7119
PTGES3	-7124
RRAGC	-7134
MAP2K3	-7266
CDKN2C	-7267
ANAPC16	-7304
ATM	-7322
DNAJB9	-7394
RPS26	-7408
PHC3	-7427
LIMD1	-7537
RHEB	-7595
CHD9	-7626
DNAJB11	-7635
MT1E	-7652
EGLN3	-7726
EDEM1	-7727
RRAGD	-7739
POT1	-7803
LMNB1	-7818
CREBRF	-7882
VENTX	-7914
ATR	-7930
CLOCK	-7948
TLR4	-8022
GPX8	-8058
GPX3	-8064
EP400	-8080
EXOSC6	-8109
HSPA13	-8146
NCOA2	-8186
NUDT2	-8194
UBE2D1	-8239
TBL1XR1	-8260
ASNS	-8269
AGO3	-8285
H2AC18	-8408
FNIP1	-8418
NOX4	-8437
DNAJA4	-8447
FNIP2	-8469
PPARA	-8477
EXOSC7	-8489
EGLN1	-8608
PPARGC1A	-8632
CYBB	-8634
APOB	-8711

---

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

	528
set	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
setSize	111
pANOVA	3.05e-08
s.dist	-0.304
p.adjustANOVA	1.48e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
LILRB5	-8695
IGKV1D-39	-8677
SIGLEC1	-8659
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
LILRB5	-8695
IGKV1D-39	-8677
SIGLEC1	-8659
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
CD33	-8284
IGHV3-11	-8247
IGLV3-19	-8185
IGHV3-48	-8053
IGKV1-5	-8050
FCGR2B	-7938
IGLV3-1	-7934
LILRB4	-7896
IGHV2-5	-7895
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
LAIR1	-7720
IGKV3-15	-7717
IGHV3-7	-7694
IGLV2-11	-7331
TRAC	-7246
CD96	-7161
IGKV1-12	-7141
VCAM1	-6848
KLRD1	-6714
SLAMF7	-6450
PVR	-6394
KLRG1	-6305
ITGB1	-5747
IGLV6-57	-5247
LILRB1	-4669
IGKC	-4532
B2M	-4394
CD300A	-4265
CLEC2D	-4261
SIGLEC10	-4164
COLEC12	-4047
OSCAR	-3996
CD226	-3654
ITGA4	-3338
NECTIN2	-3275
CD3D	-3160
ITGAL	-2947
IGHV3-23	-2920
ITGB2	-2807
HLA-H	-2484
LILRB2	-2307
CD99	-2109
LILRA6	-2029
TYROBP	-1801
CLEC2B	-1773
SH2D1B	-1651
CD3E	-1625
CD40	-1418
ITGB7	-1382
HCST	-584
FCGR3A	-536
CD1D	-388
ICAM3	-72
TREM1	620
CD22	784
SELL	1130
CD34	1225
NPDC1	1821
LILRB3	1913
LILRA2	2162
LILRA5	2242
HLA-A	2271
HLA-F	2407
PILRA	3325
JAML	3450
CD81	3762
ICAM2	3857
KLRK1	3926
TRBC1	4180
CD8A	4587
CD247	4704
TREML2	5464
PILRB	5542
IGKV1-33	5604
CD300E	5777
CD300LG	5888
CD200	6061
HLA-E	6168
ICAM1	6175
IFITM1	6269
MICA	6681
HLA-B	6686
C3	7095
HLA-C	7108

---

Cellular responses to stress

Cellular responses to stress

	174
set	Cellular responses to stress
setSize	657
pANOVA	3.47e-08
s.dist	0.127
p.adjustANOVA	1.63e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IL6	7168
ATF3	7166
FOS	7164
JUN	7163
CHAC1	7161
TXNIP	7148
HSPA1B	7087
PPP1R15A	7073
UBB	7069
HSPA1A	7054
ETS2	7048
CITED2	7010
STAP2	7003
UBC	7001
VCP	6958
UBE2C	6931
IGFBP7	6918
H2BC21	6906
H1-0	6871
H2AC6	6859

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IL6	7168
ATF3	7166
FOS	7164
JUN	7163
CHAC1	7161
TXNIP	7148
HSPA1B	7087
PPP1R15A	7073
UBB	7069
HSPA1A	7054
ETS2	7048
CITED2	7010
STAP2	7003
UBC	7001
VCP	6958
UBE2C	6931
IGFBP7	6918
H2BC21	6906
H1-0	6871
H2AC6	6859
AJUBA	6854
CCL2	6830
NPRL2	6758
HSPB8	6753
SRPRA	6752
TSPYL2	6749
STIP1	6741
SESN2	6723
HMOX1	6629
HSP90AB1	6626
HSPA12A	6621
CDKN1A	6565
PSMB3	6540
RPSA	6533
DCTN1	6446
BAG3	6393
DYNC1H1	6386
ARNTL	6375
RPL36AL	6352
KAT5	6332
MT-CO2	6275
CRYAB	6273
NFYC	6212
ATF4	6122
PARN	6097
WFS1	6071
PSMD3	6058
HELZ2	6044
WDR59	5993
PSMD1	5956
PHC1	5949
H2BC4	5939
MT-CO1	5923
PSMB5	5903
TBL1X	5900
PSMB8	5892
DDX11	5875
H2BC5	5864
PRDX2	5812
RPS2	5798
TERF2IP	5763
SERPINH1	5727
CREB3L1	5723
RING1	5704
DNAJB1	5684
RPLP2	5670
RPS15	5631
TP53	5630
RRAGA	5620
SMARCD3	5606
CBX4	5597
ANAPC1	5585
NUP62	5560
ANAPC2	5558
RPS11	5527
GPX1	5525
RPS3	5509
PSMB9	5506
ATF5	5488
RPL9	5484
ARNT	5445
RPL19	5434
HSPA1L	5431
PSMC3	5388
ATP6V0D1	5382
CRTC1	5369
PSMD2	5344
PSMB6	5343
PRDX6	5327
SLC46A1	5304
RPS9	5216
RPL18	5215
CXXC1	5189
RPLP1	5137
ELOB	5136
NUP88	5134
RPL13A	5043
TATDN2	5042
CCAR2	5041
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
PSMB4	4992
RPL37A	4988
EP300	4947
NUP188	4942
CBX8	4933
ERN1	4905
NUP98	4904
ATP6V1F	4877
STAT3	4875
HDAC6	4866
ACTR1A	4862
CEBPB	4858
RPL29	4856
RPL23A	4851
ANAPC7	4844
LMNA	4817
YWHAE	4776
NUP160	4771
PRDX1	4767
RPS19	4757
PRDX5	4756
RPL38	4753
RPS16	4751
CREB3L4	4739
CCS	4709
TLN1	4630
COX6B1	4619
RPS28	4590
SCMH1	4589
DCTN3	4584
ATP6V0E2	4569
EXOSC5	4553
RPL28	4548
TXNRD1	4516
CDC23	4497
CSNK2B	4488
SEC31A	4486
RPL3L	4465
GCN1	4436
H2BC11	4413
CAT	4378
SEC13	4359
RPL14	4354
RPS15A	4345
DCTN2	4336
RPL37	4334
RPS6KA1	4288
CUL7	4257
RPL32	4253
CREB3L2	4230
ATP6V1H	4217
HIRA	4204
PSMC4	4202
GSTP1	4174
FZR1	4121
TPR	4113
TACO1	4069
ATP6V1B2	4064
DYNLL1	4061
HDAC3	4059
EED	4045
POM121	4042
TXNRD2	4025
PSMC5	4020
COL4A6	4019
SHC1	4009
SIN3A	4005
MAPK3	3978
COX8A	3970
CDC26	3948
COX19	3911
TGS1	3888
TNRC6C	3884
HSPA2	3849
RPL41	3826
COX5B	3824
CAMK2B	3811
RPL8	3810
KEAP1	3790
NFKB1	3787
RPTOR	3785
ZBTB17	3743
RPL36	3737
CUL1	3712
H2AJ	3710
RPLP0	3705
NUP205	3685
SIN3B	3670
DEDD2	3636
ANAPC11	3622
EXOSC4	3577
ADD1	3533
RBBP7	3453
TINF2	3430
NFE2L2	3429
FAU	3409
MAPKAPK3	3401
LAMTOR2	3386
NPRL3	3383
ITFG2	3375
SRPRB	3352
RPA2	3310
HIF1AN	3275
PSMB10	3266
ANAPC5	3252
ID1	3245
RPS5	3240
RELA	3205
UBN1	3185
RNF2	3130
DNAJC7	3125
ARFGAP1	3122
HSPA12B	3116
CRTC3	3093
GPX7	3079
HSPA8	3050
PSMB7	3031
CREBBP	3022
FKBP4	2985
ATP6V1E2	2976
CBX6	2966
POM121C	2955
RPL30	2947
DEPDC5	2925
P4HB	2798
ABCC1	2780
PSMC1	2778
RPS29	2765
EHMT1	2699
HSPA9	2694
NCOR1	2691
DNAJA1	2659
H1-2	2631
CRTC2	2608
GSK3A	2599
SZT2	2589
LAMTOR4	2564
CAPZA1	2555
TXN2	2550
MOV10	2537
RPS21	2509
RPL7A	2493
CTDSP2	2492
SYVN1	2466
DDIT3	2455
RPL13	2437
HSPA4	2433
WDR24	2431
NUP93	2426
ATP6V1C2	2406
PSMA5	2400
ATP6V1E1	2399
HM13	2395
DCTN4	2382
PHC2	2304
ANAPC15	2292
CDK4	2274
RPL12	2246
ST13	2233
DYNC1I2	2194
ELOC	2152
PSMC2	2124
AKT1S1	2082
MAPK1	2069
CARM1	2068
RXRA	2060
LAMTOR5	2057
RPS13	2004
SOD3	2000
GOSR2	1975
CSNK2A1	1957
MAP2K4	1951
YIF1A	1927
MAPK14	1922
RBX1	1898
PSMB2	1820
PSMB1	1804
NUP155	1758
PSMA7	1752
CAPZB	1720
MAPK10	1695
RPS18	1690
RPL23	1687
RPL31	1652
ERF	1618
ATP6V0C	1569
UBE2S	1566
PDIA5	1552
NUP133	1546
RPL18A	1485
AR	1478
KHSRP	1456
RPS10	1452
RPS14	1447
MEF2D	1433
PREB	1403
WTIP	1391
RPL27	1373
EXOSC1	1359
RPL10	1356
PSMD7	1338
RPS23	1326
RPS20	1305
ACD	1252
EHMT2	1244
NUP214	1222
CALR	1213
BLVRB	1207
RAE1	1163
MIOS	1158
NUP85	1136
HSPA6	1132
PSMD9	1114
PSMA1	1108
HERPUD1	1066
RPL27A	1058
PSMD13	1057
EXOSC2	1035
H2AZ1	1034
SOD1	982
EPAS1	976
KLHDC3	888
MEF2C	862
KDM6B	807
PSMD6	790
ATP6V1A	775
TERF2	747
PSMF1	734
CSNK2A2	726
HSPA5	645
NR1D1	639
PSME1	622
GSR	598
KPTN	577
MT-CO3	542
RPL4	516
CREB3	500
BLVRA	489
RPL15	466
MAP2K7	432
CDKN1B	428
RPL35	420
RPS12	414
PPP2R5B	402
CBX2	390
RPL34	379
MLST8	349
CAMK2G	347
RPS27	304
TNRC6A	303
ETS1	239
RPL39	225
NPAS2	212
RPL3	207
MINK1	174
NCOA1	161
UBE2E1	155
RPS27L	146
HSF1	129
NR3C2	94
NUP153	90
MYDGF	83
COX7C	42
RPL7	-2
COX4I1	-12
RPA1	-65
SKP1	-111
PSMA2	-124
RPS27A	-177
ACADVL	-178
DNAJB6	-208
SEH1L	-247
BMI1	-268
RPL26	-335
NUP35	-363
DYNC1I1	-408
EGLN2	-420
PSMA6	-423
MAP4K4	-458
SURF1	-472
AGO1	-509
RPL10A	-551
CEBPG	-591
MAPK9	-611
RPS17	-616
RPS19BP1	-632
RBBP4	-634
CDC16	-654
HMGA1	-659
RPL17	-661
HMOX2	-672
PSMD11	-674
NCF2	-687
COX14	-774
PSMD5	-792
MBTPS1	-818
RPS24	-856
NFYA	-887
ATP6V1C1	-904
E2F1	-916
ATF2	-922
MAPK11	-930
XBP1	-935
EIF2AK1	-966
TFDP1	-989
HSPH1	-999
PGR	-1028
HIKESHI	-1031
DCTN5	-1040
AAAS	-1069
RPS8	-1110
CABIN1	-1113
NDUFA4	-1120
FBXL17	-1225
RPA3	-1236
RPS4Y1	-1305
MAP2K6	-1310
H2BC15	-1351
SEM1	-1355
SERP1	-1358
NUP107	-1364
DCTN6	-1395
PSMD14	-1462
RPL21	-1476
EIF2AK4	-1478
NCOA6	-1537
CUL3	-1558
H2BC12	-1620
MRPL18	-1646
DYNLL2	-1679
PSME3	-1684
EIF2S2	-1692
EEF1A1	-1696
ATOX1	-1727
RPL26L1	-1755
LAMTOR1	-1804
NUP42	-1817
MTOR	-1833
RPL6	-1834
EXTL1	-1857
ATP6V0E1	-1867
MED1	-1907
RPL35A	-1915
SULT1A3	-1939
COX6C	-1988
RPL5	-2001
DYNC1LI1	-2020
CREB1	-2036
PSMC6	-2073
NUP50	-2132
CCNA2	-2135
PSMA4	-2141
RPS6KA2	-2146
NOX5	-2218
RPS4X	-2225
TNRC6B	-2247
UBE2D2	-2273
RPS6	-2299
COX5A	-2355
COX7B	-2369
RPL11	-2374
CYBA	-2381
SKP2	-2390
SCO2	-2485
DIS3	-2531
RPS3A	-2553
HYOU1	-2566
VHL	-2576
PRDX3	-2589
LY96	-2597
EXTL2	-2616
E2F3	-2620
EIF2S3	-2635
MDM2	-2814
MAFK	-2828
LRPPRC	-2953
NCOR2	-2980
MAPKAPK2	-3012
RPS25	-3129
COX6A1	-3146
FLCN	-3172
RPL22	-3228
SUZ12	-3267
CDKN2B	-3350
E2F2	-3359
TCIRG1	-3382
ATP6V0B	-3410
BACH1	-3446
RPL22L1	-3463
CAMK2D	-3485
RPL24	-3530
DYNC1LI2	-3547
CCNE1	-3589
BAG5	-3612
NUP43	-3666
PSMA3	-3674
HSBP1	-3691
EZH2	-3818
HSPA7	-4032
ACTR10	-4045
HSP90AA1	-4069
EXTL3	-4083
RAI1	-4103
ATP6V1D	-4106
GFPT1	-4146
DCP2	-4168
EIF2S1	-4256
ASF1A	-4277
COX11	-4278
TPP1	-4310
PSMD10	-4314
HIF3A	-4319
HDGF	-4320
MAPK7	-4332
EXOSC9	-4334
TNIK	-4337
HSPA14	-4361
NBN	-4368
AGO4	-4407
ATP6V1G1	-4422
PSMD12	-4430
CDKN2D	-4473
SIRT1	-4509
NUP54	-4512
NRIP1	-4523
RPS7	-4550
SSR1	-4595
SP1	-4631
TNFRSF21	-4674
VEGFA	-4711
EXOSC8	-4755
RRAGB	-4796
SOD2	-4808
CDK2	-4871
KDELR3	-4960
TERF1	-5006
DNAJA2	-5051
COX20	-5054
NUP37	-5077
EXOSC3	-5079
SCO1	-5171
NUP210	-5199
COX16	-5203
CUL2	-5250
RB1	-5310
ATF6	-5311
FKBP5	-5338
PDIA6	-5343
NCF1	-5347
NUP58	-5351
HSPA4L	-5367
ATP6V1G2	-5405
FKBP14	-5413
XPO1	-5416
LAMTOR3	-5422
UBE2D3	-5531
CDC27	-5554
PRKCD	-5561
CDK6	-5574
NR3C1	-5578
SLC38A9	-5579
PLA2G4B	-5651
MAPK8	-5685
NFYB	-5690
SH3BP4	-5753
BAG1	-5782
MAPKAPK5	-5789
RPL36A	-5827
HIF1A	-5830
TFDP2	-5832
BAG2	-5879
TXN	-5883
IMPACT	-5966
BMT2	-5975
GRB10	-6014
MAP3K5	-6097
CAPZA2	-6125
PSME4	-6160
DNAJC3	-6166
BAG4	-6204
ERO1A	-6206
GSK3B	-6221
CAMK2A	-6259
RANBP2	-6291
COX7A2L	-6342
TRIB3	-6402
RPS6KA3	-6448
SESN1	-6453
H2AZ2	-6464
HSP90B1	-6513
H3-3A	-6551
HBA1	-6577
CYCS	-6623
HIGD1A	-6635
MBTPS2	-6667
RORA	-6674
ANAPC10	-6689
EIF2AK3	-6696
COX18	-6706
HBB	-6775
WIPI1	-6873
MDM4	-6890
ATP7A	-6928
MRE11	-6945
RAD50	-7036
ANAPC4	-7047
NDC1	-7051
DNAJC2	-7079
NCF4	-7119
PTGES3	-7124
RRAGC	-7134
MAP2K3	-7266
CDKN2C	-7267
ANAPC16	-7304
ATM	-7322
DNAJB9	-7394
RPS26	-7408
PHC3	-7427
LIMD1	-7537
RHEB	-7595
CHD9	-7626
DNAJB11	-7635
EGLN3	-7726
EDEM1	-7727
RRAGD	-7739
POT1	-7803
LMNB1	-7818
CREBRF	-7882
VENTX	-7914
ATR	-7930
CLOCK	-7948
TLR4	-8022
GPX8	-8058
GPX3	-8064
EP400	-8080
EXOSC6	-8109
HSPA13	-8146
NCOA2	-8186
NUDT2	-8194
UBE2D1	-8239
TBL1XR1	-8260
ASNS	-8269
AGO3	-8285
H2AC18	-8408
FNIP1	-8418
NOX4	-8437
DNAJA4	-8447
FNIP2	-8469
PPARA	-8477
EXOSC7	-8489
EGLN1	-8608
PPARGC1A	-8632
CYBB	-8634
APOB	-8711

---

Axon guidance

Axon guidance

	101
set	Axon guidance
setSize	456
pANOVA	3.62e-08
s.dist	0.151
p.adjustANOVA	1.65e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GDNF	7169
RHOB	7145
NCAM1	7122
UBB	7069
DPYSL4	7045
UBC	7001
SCN4B	6967
MYH11	6937
L1CAM	6930
PLXNB3	6926
SEMA6A	6924
SEMA6D	6885
EFNB1	6731
CLTCL1	6715
HSP90AB1	6626
SEMA4D	6612
EZR	6592
PLXNB1	6583
SCN5A	6582
PSMB3	6540

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GDNF	7169
RHOB	7145
NCAM1	7122
UBB	7069
DPYSL4	7045
UBC	7001
SCN4B	6967
MYH11	6937
L1CAM	6930
PLXNB3	6926
SEMA6A	6924
SEMA6D	6885
EFNB1	6731
CLTCL1	6715
HSP90AB1	6626
SEMA4D	6612
EZR	6592
PLXNB1	6583
SCN5A	6582
PSMB3	6540
PDLIM7	6536
RPSA	6533
MYO10	6528
PAK1	6509
EFNA4	6496
EPHA2	6472
PIK3R1	6465
LAMB1	6450
NEO1	6436
SPTBN5	6428
EIF4A3	6413
PRNP	6409
RPL36AL	6352
PRKCQ	6333
ITGA9	6304
COL4A3	6295
ROBO1	6242
EPHB3	6114
PSMD3	6058
DOCK1	6051
AGAP2	6022
PSMD1	5956
PSMB5	5903
PSMB8	5892
CRMP1	5806
RPS2	5798
ARHGAP39	5746
LIMK2	5711
RPLP2	5670
COL6A2	5662
RPS15	5631
CNTNAP1	5603
RGMB	5584
NCK2	5545
RPS11	5527
COL4A4	5522
RPS3	5509
PSMB9	5506
RPL9	5484
EIF4G1	5479
RPL19	5434
ARHGEF28	5427
SCN8A	5412
PSMC3	5388
PSMD2	5344
PSMB6	5343
SEMA7A	5307
COL9A3	5305
SRC	5289
RPS9	5216
RPL18	5215
SLIT3	5141
RPLP1	5137
ELOB	5136
NCSTN	5091
SHANK3	5047
RPL13A	5043
MYL9	5040
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
HRAS	5006
MYH14	5004
PSMB4	4992
RPL37A	4988
CNTN1	4984
EPHB1	4950
COL4A1	4943
CLTB	4872
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
MYL6	4688
ZSWIM8	4646
TLN1	4630
ACTB	4598
RPS28	4590
COL4A2	4560
RPL28	4548
TIAM1	4542
CSNK2B	4488
RPL3L	4465
EFNB2	4451
SPTBN1	4389
RPL14	4354
RPS15A	4345
RPL37	4334
RPS6KA1	4288
RPL32	4253
LYPLA2	4242
PAK4	4228
NUMB	4213
PSMC4	4202
DOK1	4106
COL9A2	4103
GSPT2	4044
CFL1	4031
ABLIM2	4024
PSMC5	4020
SHC1	4009
MAPK3	3978
CACNA1H	3908
SPTAN1	3906
RPL41	3826
RPL8	3810
ANK1	3809
RANBP9	3799
AP2S1	3753
RPL36	3737
ITGA10	3720
RPLP0	3705
PSEN2	3671
CAP2	3621
CACNA1S	3615
DLG4	3572
MAP2K1	3553
ABLIM3	3520
GPC1	3507
PLCG1	3502
ACTG1	3415
FAU	3409
ARPC1A	3340
SIAH2	3333
FARP2	3315
PLXND1	3298
PSMB10	3266
MAPK13	3255
RPS5	3240
SPTBN2	3157
AP2B1	3063
EFNA1	3057
HSPA8	3050
PSMB7	3031
RPL30	2947
CLTA	2934
CD72	2820
PSMC1	2778
RPS29	2765
MYH9	2741
PTPRA	2723
DNM2	2701
AP2A2	2632
MAP2K2	2618
PIK3R2	2602
MYL12B	2573
RELN	2556
SCN4A	2539
VAV2	2529
NRP2	2515
RPS21	2509
RPL7A	2493
CACNB1	2475
RPL13	2437
PSMA5	2400
SIAH1	2368
EPHA4	2324
RPL12	2246
RHOC	2169
ELOC	2152
PSMC2	2124
MAPK1	2069
UPF2	2033
RGMA	2022
RPS13	2004
GIT1	1958
CSNK2A1	1957
MAPK14	1922
RBX1	1898
DNM3	1873
FGFR1	1828
PSMB2	1820
SCN1B	1809
PSMB1	1804
PSMA7	1752
ARHGEF7	1693
RPS18	1690
RPL23	1687
RPL31	1652
SLIT1	1643
ERBB2	1598
MAGOH	1590
ARPC4	1580
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
ABL1	1363
RPL10	1356
CXCR4	1350
PSMD7	1338
RPS23	1326
RPS20	1305
AP2M1	1276
LDB1	1245
SCN3B	1166
CHL1	1125
PSMD9	1114
PSMA1	1108
RPL27A	1058
PSMD13	1057
COL6A1	1051
GAB2	1024
EPHB6	986
PRKACA	933
PITPNA	878
SLIT2	875
CAP1	849
ANK2	813
PSMD6	790
NCK1	742
PSMF1	734
CSNK2A2	726
VAV3	716
CASC3	674
PFN1	627
PSME1	622
MET	567
NRP1	566
CACNA1C	525
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
ANK3	216
RPL3	207
RPS27L	146
RNPS1	144
ITSN1	78
PIK3CD	66
EGFR	24
AP2A1	2
RPL7	-2
NFASC	-15
PSMA2	-124
RPS27A	-177
PLXNA4	-291
EPHB4	-294
RPL26	-335
CLTC	-338
RHOA	-387
CLASP1	-395
PSMA6	-423
PLXNA3	-440
VASP	-447
APH1A	-462
PLXNC1	-471
MSN	-527
SPTBN4	-529
KALRN	-547
RPL10A	-551
RPS17	-616
RAC1	-651
RPL17	-661
PSMD11	-674
MMP2	-682
CDK5	-764
GRB2	-787
SRGAP1	-791
PSMD5	-792
SOS2	-819
RPS24	-856
COL6A3	-900
MAPK11	-930
PTK2	-936
PPP3CB	-967
RBM8A	-1037
RPS8	-1110
PFN2	-1187
APH1B	-1232
COL4A5	-1242
ARHGEF11	-1247
NCBP2	-1265
DOK4	-1300
RPS4Y1	-1305
SEM1	-1355
LIMK1	-1361
PTPRC	-1414
PSMD14	-1462
RPL21	-1476
NGEF	-1495
RPS6KA4	-1568
EVL	-1571
PSME3	-1684
RPL26L1	-1755
RET	-1761
MAPK12	-1789
UPF3B	-1799
TYROBP	-1801
EPHA3	-1820
RPL6	-1834
LAMC1	-1835
RPL35A	-1915
DAG1	-1926
PLXNA1	-1965
PLXNA2	-1984
RPL5	-2001
RDX	-2017
CREB1	-2036
PSMC6	-2073
MYO9B	-2121
PSMA4	-2141
RPS6KA2	-2146
CACNB3	-2194
RPS4X	-2225
RPS6	-2299
DPYSL3	-2325
AGRN	-2334
RPL11	-2374
UPF3A	-2450
RPS3A	-2553
RPS6KA6	-2599
SRGAP2	-2601
MYH10	-2642
RRAS	-2656
PSEN1	-2856
DLG3	-2993
GSPT1	-2996
ARPC5	-3020
RPS6KA5	-3028
RPS25	-3129
RPL22	-3228
PRKAR2A	-3291
RASA1	-3386
RPL22L1	-3463
PSENEN	-3511
RPL24	-3530
CLASP2	-3540
ETF1	-3636
PSMA3	-3674
UNC5B	-3775
SEMA5A	-3788
DLG1	-3888
SPTB	-3910
HSP90AA1	-4069
SPTA1	-4170
CDK5R1	-4220
NCBP1	-4287
PSMD10	-4314
MAPK7	-4332
MMP9	-4336
ABL2	-4397
ST8SIA4	-4403
PSMD12	-4430
FYN	-4434
SEMA4A	-4440
PABPC1	-4540
RPS7	-4550
GAB1	-4602
SCN9A	-4688
SHTN1	-4738
NRAS	-4823
CXCL12	-4878
MAGOHB	-4885
FES	-4901
TRPC1	-4906
ACTR3	-4907
LYN	-4973
DOK2	-5034
ARHGAP35	-5059
PAK6	-5101
ARPC2	-5121
CUL2	-5250
PTPN11	-5259
VLDLR	-5264
ARPC1B	-5365
WASL	-5406
PIK3CA	-5439
NTN4	-5462
FRS2	-5466
DOK5	-5469
MYL12A	-5471
PAK2	-5599
SRGAP3	-5625
ACTR2	-5629
ROCK2	-5656
MAPK8	-5685
ITGB1	-5747
TRIO	-5777
RPL36A	-5827
ENAH	-5841
CDC42	-5909
ITGA2	-5944
GRB10	-6014
GFRA2	-6088
ITGA1	-6109
PSME4	-6160
ROBO3	-6170
SDCBP	-6188
GSK3B	-6221
SCN7A	-6224
FLRT3	-6285
ITGA2B	-6287
ADAM10	-6298
SOS1	-6323
PIP5K1C	-6386
USP33	-6398
RPS6KA3	-6448
PRKCA	-6547
PIK3CB	-6671
PAK3	-6715
LHX4	-6874
ITGA5	-6957
PIK3R3	-6979
ALCAM	-7006
ARPC3	-7025
GFRA1	-7041
CD24	-7128
SH3KBP1	-7233
ROCK1	-7237
SEMA3A	-7306
SHC3	-7397
RPS26	-7408
DPYSL2	-7489
YES1	-7544
SCN2B	-7697
SCN3A	-7776
EFNA5	-7796
SDC2	-7832
ITGAV	-7838
NELL2	-7844
PRKACB	-7886
KRAS	-7901
NTN1	-7919
ARHGEF12	-7956
COL6A6	-8270
CACNB2	-8478
ABLIM1	-8483
ITGB3	-8655
IRS2	-8696
DNM1	-8699

---

Anti-inflammatory response favouring Leishmania parasite infection

Anti-inflammatory response favouring Leishmania parasite infection

	74
set	Anti-inflammatory response favouring Leishmania parasite infection
setSize	132
pANOVA	4.08e-08
s.dist	-0.277
p.adjustANOVA	1.74e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
GPBAR1	-8502
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
PTGDR	-8450

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
GPBAR1	-8502
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
PTGDR	-8450
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
POMC	-8193
IGLV3-19	-8185
ADORA2B	-8158
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
PRKACB	-7886
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
CALCRL	-7603
YES1	-7544
CD163	-7520
GNB4	-7504
GNG10	-7412
GNG12	-7333
IGLV2-11	-7331
SYK	-7265
GNG7	-7262
IGKV1-12	-7141
FCGR2A	-6859
GNG2	-6843
ITPR2	-6797
FGR	-6559
PRKAR2B	-6370
ADAM17	-6043
HRH2	-5864
PRKX	-5513
PTGIR	-5495
ADORA2A	-5346
IGLV6-57	-5247
GPR27	-5204
LYN	-4973
ITPR1	-4601
IGKC	-4532
FYN	-4434
RHBDF2	-3976
GNG5	-3917
GPR176	-3635
TSHR	-3519
PRKAR2A	-3291
IGHV3-23	-2920
RAMP2	-2501
GNG11	-2444
CRHR2	-2236
CREB1	-2036
GNB1	-1927
GNAI3	-1900
ADCY7	-1634
ADRB2	-1258
GNB3	-1170
GNAI1	-1077
ADCY1	-1051
FCGR3A	-536
FURIN	-473
PTGER2	-333
PLCG2	133
AVPR2	646
PRKAR1B	704
P2RY11	825
PRKACA	933
GGT1	1160
RAMP1	1378
ADCY9	1440
ADCY2	1607
ADCY6	1874
MAPK14	1922
HCK	1982
MYH9	2741
GNAI2	2833
VIPR1	2984
ADCY5	3046
DPEP2	3212
PLCG1	3502
VIPR2	3698
ITPR3	4090
PRKAR1A	4240
GNB2	4310
GNAZ	4484
GNB5	4679
CD247	4704
GNAS	5169
SRC	5289
ADM	5468
MC1R	5586
IGKV1-33	5604
HTR7	5652
ADCY4	5725
ADCYAP1R1	5781
ADCY3	5809
PTH1R	6240
PTGER4	6378
RAMP3	6412
SCT	6688
GGT5	6743
AHCYL1	6766
CALM1	6889
PLK2	7089
IL6	7168

---

Leishmania parasite growth and survival

Leishmania parasite growth and survival

	608
set	Leishmania parasite growth and survival
setSize	132
pANOVA	4.08e-08
s.dist	-0.277
p.adjustANOVA	1.74e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
GPBAR1	-8502
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
PTGDR	-8450

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IGLV3-25	-8702
IGKV1D-39	-8677
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
IGHG3	-8592
IGLC2	-8581
IGLC3	-8573
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
GPBAR1	-8502
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
PTGDR	-8450
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGHG2	-8406
IGLV1-40	-8378
IGKV2-28	-8351
IGHV4-59	-8339
IGHV3-11	-8247
POMC	-8193
IGLV3-19	-8185
ADORA2B	-8158
IGHV3-48	-8053
IGKV1-5	-8050
IGHG4	-8032
IGLV3-1	-7934
IGHG1	-7925
IGHV2-5	-7895
PRKACB	-7886
IGLV8-61	-7873
IGHV4-39	-7760
IGKV3-20	-7744
IGKV3-15	-7717
IGHV3-7	-7694
CALCRL	-7603
YES1	-7544
CD163	-7520
GNB4	-7504
GNG10	-7412
GNG12	-7333
IGLV2-11	-7331
SYK	-7265
GNG7	-7262
IGKV1-12	-7141
FCGR2A	-6859
GNG2	-6843
ITPR2	-6797
FGR	-6559
PRKAR2B	-6370
ADAM17	-6043
HRH2	-5864
PRKX	-5513
PTGIR	-5495
ADORA2A	-5346
IGLV6-57	-5247
GPR27	-5204
LYN	-4973
ITPR1	-4601
IGKC	-4532
FYN	-4434
RHBDF2	-3976
GNG5	-3917
GPR176	-3635
TSHR	-3519
PRKAR2A	-3291
IGHV3-23	-2920
RAMP2	-2501
GNG11	-2444
CRHR2	-2236
CREB1	-2036
GNB1	-1927
GNAI3	-1900
ADCY7	-1634
ADRB2	-1258
GNB3	-1170
GNAI1	-1077
ADCY1	-1051
FCGR3A	-536
FURIN	-473
PTGER2	-333
PLCG2	133
AVPR2	646
PRKAR1B	704
P2RY11	825
PRKACA	933
GGT1	1160
RAMP1	1378
ADCY9	1440
ADCY2	1607
ADCY6	1874
MAPK14	1922
HCK	1982
MYH9	2741
GNAI2	2833
VIPR1	2984
ADCY5	3046
DPEP2	3212
PLCG1	3502
VIPR2	3698
ITPR3	4090
PRKAR1A	4240
GNB2	4310
GNAZ	4484
GNB5	4679
CD247	4704
GNAS	5169
SRC	5289
ADM	5468
MC1R	5586
IGKV1-33	5604
HTR7	5652
ADCY4	5725
ADCYAP1R1	5781
ADCY3	5809
PTH1R	6240
PTGER4	6378
RAMP3	6412
SCT	6688
GGT5	6743
AHCYL1	6766
CALM1	6889
PLK2	7089
IL6	7168

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	146
set	Cap-dependent Translation Initiation
setSize	117
pANOVA	6.37e-08
s.dist	0.29
p.adjustANOVA	2.57e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF2B4	6247
EIF4A1	6142
EIF2B2	6079
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF2B4	6247
EIF4A1	6142
EIF2B2	6079
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
EIF2B3	4474
RPL3L	4465
EIF2B5	4391
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
EIF3I	3667
EIF3B	3604
FAU	3409
RPS5	3240
EIF3F	3233
EIF3H	3034
RPL30	2947
EIF2B1	2836
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
EIF3K	1840
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
EIF4B	1330
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
EIF4A2	-418
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
EIF2S2	-1692
RPL26L1	-1755
EIF5	-1822
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
EIF3M	-2604
EIF2S3	-2635
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
EIF5B	-3535
EIF3E	-4214
EIF2S1	-4256
PABPC1	-4540
RPS7	-4550
EIF1AX	-4691
EIF4E	-5182
EIF3J	-5510
RPL36A	-5827
RPS26	-7408
EIF4EBP1	-7964

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	361
set	Eukaryotic Translation Initiation
setSize	117
pANOVA	6.37e-08
s.dist	0.29
p.adjustANOVA	2.57e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF2B4	6247
EIF4A1	6142
EIF2B2	6079
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF2B4	6247
EIF4A1	6142
EIF2B2	6079
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
EIF2B3	4474
RPL3L	4465
EIF2B5	4391
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
EIF3I	3667
EIF3B	3604
FAU	3409
RPS5	3240
EIF3F	3233
EIF3H	3034
RPL30	2947
EIF2B1	2836
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
EIF3K	1840
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
EIF4B	1330
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
EIF4A2	-418
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
EIF2S2	-1692
RPL26L1	-1755
EIF5	-1822
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
EIF3M	-2604
EIF2S3	-2635
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
EIF5B	-3535
EIF3E	-4214
EIF2S1	-4256
PABPC1	-4540
RPS7	-4550
EIF1AX	-4691
EIF4E	-5182
EIF3J	-5510
RPL36A	-5827
RPS26	-7408
EIF4EBP1	-7964

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	403
set	Formation of a pool of free 40S subunits
setSize	99
pANOVA	8.95e-08
s.dist	0.311
p.adjustANOVA	3.51e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
EIF3D	5291
EIF3A	5270
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
EIF3D	5291
EIF3A	5270
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
EIF3I	3667
EIF3B	3604
FAU	3409
RPS5	3240
EIF3F	3233
EIF3H	3034
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
EIF3K	1840
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
EIF3M	-2604
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
EIF3E	-4214
RPS7	-4550
EIF1AX	-4691
EIF3J	-5510
RPL36A	-5827
RPS26	-7408

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	360
set	Eukaryotic Translation Elongation
setSize	92
pANOVA	9.78e-08
s.dist	0.322
p.adjustANOVA	3.73e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPSA	6533
EEF1A2	6354
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
EEF1D	5602
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
EEF2	4907
RPL29	4856
RPL23A	4851

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPSA	6533
EEF1A2	6354
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
EEF1D	5602
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
EEF2	4907
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
EEF1G	4033
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
FAU	3409
RPS5	3240
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
RPS18	1690
RPL23	1687
EEF1A1P5	1672
RPL31	1652
EEF1B2	1575
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
EEF1A1	-1696
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
RPS7	-4550
RPL36A	-5827
RPS26	-7408

---

Hemostasis

Hemostasis

	504
set	Hemostasis
setSize	501
pANOVA	1.13e-07
s.dist	-0.139
p.adjustANOVA	4.18e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APOB	-8711
IGLV3-25	-8702
TFPI	-8683
IGKV1D-39	-8677
ITGB3	-8655
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
KIFC1	-8593
IGLC2	-8581
IGLC3	-8573
GATA1	-8569
AK3	-8565
MMRN1	-8543
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APOB	-8711
IGLV3-25	-8702
TFPI	-8683
IGKV1D-39	-8677
ITGB3	-8655
IGLV2-23	-8654
IGLV2-14	-8630
IGHV1-2	-8618
IGHV4-34	-8617
IGLV1-47	-8598
KIFC1	-8593
IGLC2	-8581
IGLC3	-8573
GATA1	-8569
AK3	-8565
MMRN1	-8543
IGLV3-21	-8526
IGLC1	-8517
IGHV3-33	-8516
IGHV3-30	-8506
IGKV2-30	-8501
IGKV4-1	-8499
IGKV1-17	-8474
IGLV1-44	-8454
IGHA2	-8438
IGLV1-51	-8431
IGKV3-11	-8426
IGLV2-8	-8419
IGLV1-40	-8378
CD2	-8369
CD109	-8366
IGKV2-28	-8351
SDC1	-8347
IGHV4-59	-8339
SERPINE1	-8330
CD44	-8311
JCHAIN	-8307
IGHV3-11	-8247
IGLV3-19	-8185
DGKH	-8181
S100A10	-8154
PDE1A	-8099
IGHV3-48	-8053
IGKV1-5	-8050
PPP2R5A	-8040
NHLRC2	-8005
SLC7A8	-7947
IGLV3-1	-7934
F13A1	-7923
KRAS	-7901
IGHV2-5	-7895
PRKACB	-7886
IGLV8-61	-7873
SLC7A7	-7856
ITGAV	-7838
SDC2	-7832
IGHA1	-7806
ITGAM	-7762
IGHV4-39	-7760
ENDOD1	-7752
KIF27	-7751
DGKG	-7749
IGKV3-20	-7744
GUCY1A2	-7734
IGKV3-15	-7717
F5	-7702
IGHV3-7	-7694
CD47	-7687
CABLES1	-7643
PDPN	-7616
SPN	-7611
DOCK11	-7550
YES1	-7544
CD58	-7532
GNB4	-7504
FN1	-7429
GNG10	-7412
CDC37L1	-7387
GNG12	-7333
IGLV2-11	-7331
PAFAH2	-7318
P2RX1	-7317
SYK	-7265
GNG7	-7262
TMX3	-7239
KIF2A	-7226
F2R	-7222
ATP2A3	-7205
JAK2	-7193
TIMP3	-7190
IGKV1-12	-7141
PCYOX1L	-7136
GNA13	-7120
PROCR	-7111
FAM3C	-7002
PIK3R3	-6979
ITGA5	-6957
KIF11	-6944
CD9	-6929
CLU	-6913
CARMIL1	-6912
WEE1	-6902
PRTN3	-6860
KIF3A	-6858
GNG2	-6843
SLC16A3	-6801
ITPR2	-6797
KIF20B	-6793
MFN1	-6791
HBB	-6775
DGKE	-6722
FERMT3	-6698
CRK	-6681
CTSW	-6680
FCER1G	-6672
PIK3CB	-6671
PIK3R6	-6656
SLC8A1	-6651
PPP2R1B	-6616
ARRB2	-6595
FGR	-6559
H3-3A	-6551
PRKCA	-6547
CD177	-6543
GP1BB	-6497
PROS1	-6484
ITIH4	-6469
IGHM	-6441
CALU	-6431
IRF2	-6421
PPP2R5E	-6387
PRKAR2B	-6370
IGF1	-6365
SOS1	-6323
F8	-6295
PRKG1	-6292
ITGA2B	-6287
F3	-6281
PDE10A	-6264
SRGN	-6256
MERTK	-6249
KIF2C	-6227
CAPZA2	-6125
ITGA1	-6109
CLEC3B	-6092
PDGFA	-6046
CAV1	-6027
YWHAZ	-6003
PLEK	-5990
PHACTR2	-5964
ITGA2	-5944
SELENOP	-5943
RAC2	-5941
CDC42	-5909
RAP1A	-5906
PPP2CA	-5902
ECM1	-5807
CD84	-5801
TF	-5756
ITGB1	-5747
CEACAM6	-5739
CEACAM8	-5728
ATP1B1	-5668
CD36	-5611
CBX5	-5592
PRKCD	-5561
APOOL	-5557
SERPINE2	-5504
PTGIR	-5495
SH2B3	-5451
DOCK4	-5444
PIK3CA	-5439
SELP	-5430
LRP8	-5418
STXBP3	-5364
PTPN11	-5259
IGLV6-57	-5247
OLA1	-5193
LAMP2	-5187
PF4	-5169
ATP2B4	-5133
KIF1B	-5099
HABP4	-5076
GNA15	-5073
AKT1	-5072
DOK2	-5034
SYTL4	-4983
LYN	-4973
MAFF	-4925
CDK2	-4871
AKAP1	-4833
NRAS	-4823
TAGLN2	-4822
LCP2	-4775
KIF5B	-4746
VEGFA	-4711
RAD51C	-4684
DGKA	-4627
TGFB1	-4611
ITPR1	-4601
IGKC	-4532
SLC16A1	-4490
PPP2CB	-4479
SERPINB8	-4455
FYN	-4434
VEGFB	-4406
RAP1B	-4229
STXBP2	-4223
GNAQ	-4199
VTI1B	-4121
PPP2R5C	-4079
RAB5A	-4033
JMJD1C	-4025
LHFPL2	-3972
ORAI2	-3919
GNG5	-3917
DOCK3	-3905
NFE2	-3864
AKAP10	-3832
DOCK10	-3754
P2RX7	-3631
SERPINB6	-3387
RASGRP2	-3371
ITGA4	-3338
ISLR	-3323
CYRIB	-3321
TOR4A	-3295
PRKAR2A	-3291
PPBP	-3195
GYPA	-3064
MAGED2	-3024
ITGAL	-2947
IGHV3-23	-2920
SRI	-2904
SERPINF2	-2830
MAFK	-2828
ITGB2	-2807
ATP1B3	-2801
ORAI1	-2776
GNA11	-2773
RAPGEF3	-2689
DOCK2	-2672
ZFPM1	-2671
ABCC4	-2636
JAM3	-2596
ITIH3	-2454
GNG11	-2444
DOCK7	-2384
KCNMB3	-2379
GYPB	-2328
HBD	-2289
RHOG	-2283
CEACAM3	-2279
HDAC2	-2256
ATP2B1	-2190
MICAL1	-2159
CD99	-2109
ATP1B2	-2041
APBB1IP	-1993
CSK	-1956
GNB1	-1927
PRCP	-1921
GNAI3	-1900
IRAG1	-1887
PLAUR	-1883
PDE5A	-1876
TBXA2R	-1831
MANF	-1829
JAM2	-1798
NOS1	-1771
ATP2B2	-1765
HMG20B	-1713
TUBA4A	-1711
LAT	-1693
PDPK1	-1669
PRKCE	-1533
RBSN	-1516
KIF21A	-1329
GATA2	-1327
CHID1	-1322
GNB3	-1170
ACTN2	-1085
PLG	-1083
GNAI1	-1077
KIF9	-1045
KCNMA1	-1005
PDE2A	-963
PTK2	-936
VEGFD	-869
RACGAP1	-802
VAV1	-788
GRB2	-787
CDK5	-764
KIF26A	-747
F11R	-736
RAC1	-651
KIFAP3	-587
LCK	-474
RHOA	-387
CD99L2	-347
PLA2G4A	-342
C1QBP	-250
PTPN6	-210
ANGPT1	-188
ITGAX	-155
DOCK8	-131
KIF21B	-17
KIF1C	40
KIF5C	56
GNA12	72
PLCG2	133
SH2B2	214
KCNMB4	277
TSPAN7	279
ABHD12	326
TNFRSF10B	392
PPP2R5B	402
MAFG	494
TMSB4X	592
TREM1	620
PFN1	627
HSPA5	645
DAGLA	693
PRKAR1B	704
VAV3	716
KIF13B	796
BRPF3	831
CAP1	849
PIK3R5	861
GP1BA	926
PRKACA	933
SOD1	982
SDC4	1098
TNFRSF10D	1104
SELL	1130
P2RX4	1156
KIFC2	1191
RAPGEF4	1194
GAS6	1259
ITGA6	1320
DOCK6	1321
SLC7A5	1353
ABL1	1363
ATP2A1	1398
RAD51B	1426
DGKZ	1537
ACTN1	1603
GTPBP2	1608
BSG	1665
ADRA2B	1696
CAPZB	1720
ITPK1	1725
SCCPDH	1833
CD63	1846
KIF3B	1872
VEGFC	1891
TTN	1892
TIMP1	1905
MAPK14	1922
KIF16B	1943
EHD3	2061
MAPK1	2069
GYPC	2170
RAF1	2178
SH2B1	2223
PDGFB	2245
DGKQ	2250
TEK	2260
VPS45	2333
KLC2	2337
PPP2R5D	2415
EHD1	2419
VAV2	2529
CAPZA1	2555
CFD	2597
PIK3R2	2602
CD48	2629
PLAT	2645
PRKCH	2673
ADRA2C	2811
GNAI2	2833
SLC16A8	2871
SELPLG	2921
FLNA	2981
ABHD6	2994
KIF3C	3085
ANXA2	3144
STIM1	3197
APLP2	3226
RCOR1	3279
KLC1	3326
ACTN4	3355
PRKCB	3398
JAML	3450
PPIA	3464
PLCG1	3502
GPC1	3507
P2RY1	3547
PIK3CG	3580
PTPN1	3603
WDR1	3686
PSAP	3704
ITGA10	3720
KIF25	3751
ATP2A2	3773
ARRB1	3786
SERPINA1	3839
BCAR1	3865
PDE1B	3901
MIF	3956
MAPK3	3978
DOCK9	4001
TEX264	4002
SIN3A	4005
SHC1	4009
CFL1	4031
ITPR3	4090
ALDOA	4123
STX4	4222
PRKAR1A	4240
HDAC1	4274
SERPING1	4305
GNB2	4310
DAGLB	4319
CABLES2	4333
EHD2	4341
MFN2	4374
GRB14	4383
SDC3	4482
THPO	4500
KDM1A	4514
KLC4	4529
KCNMB1	4543
ADRA2A	4562
CEACAM1	4603
TLN1	4630
CYB5R1	4645
AAMP	4659
ESAM	4662
GNB5	4679
MGLL	4836
P2RX5	4863
A1BG	4901
DOCK5	4918
GATA3	4936
TGFB3	4948
TNFRSF10A	4983
ANGPT2	4994
HRAS	5006
DGKD	5049
PHF21A	5118
RARRES2	5143
GNAS	5169
PECAM1	5176
VCL	5238
SRC	5289
PDE9A	5355
PICK1	5393
HGF	5413
TGFB2	5425
ANXA5	5440
IGKV1-33	5604
SLC7A6	5623
TP53	5630
SERPINA3	5633
PPIL2	5654
SLC8A3	5675
QSOX1	5728
EGF	5766
NOS3	5873
SLC3A2	6038
ITGA3	6040
DOCK1	6051
INPP5D	6167
P2RX6	6171
GLG1	6203
A2M	6281
SERPINA5	6284
PRKCQ	6333
ZFPM2	6351
PDE11A	6359
CD74	6368
PPP2R1A	6382
PIK3R1	6465
SIRPA	6591
APP	6594
IGF2	6635
LGALS3BP	6693
THBS1	6719
F10	6772
KIF22	6834
PLAU	6855
VWF	6873
KIF19	6875
CALM1	6889
L1CAM	6930
THBD	6966
IRF1	6973
SPARC	7072
NOS2	7098
RHOB	7145

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	599
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	109
pANOVA	1.54e-07
s.dist	0.291
p.adjustANOVA	5.57e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF4A1	6142
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF4A1	6142
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
EIF3I	3667
EIF3B	3604
FAU	3409
RPS5	3240
EIF3F	3233
EIF3H	3034
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
EIF3K	1840
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
EIF4B	1330
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
EIF4A2	-418
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
EIF2S2	-1692
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
EIF3M	-2604
EIF2S3	-2635
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
EIF3E	-4214
EIF2S1	-4256
PABPC1	-4540
RPS7	-4550
EIF1AX	-4691
EIF4E	-5182
EIF3J	-5510
RPL36A	-5827
RPS26	-7408

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	443
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	110
pANOVA	1.76e-07
s.dist	0.288
p.adjustANOVA	6.21e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF4A1	6142
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF3C	6896
RPSA	6533
RPL36AL	6352
EIF4A1	6142
RPS2	5798
RPLP2	5670
RPS15	5631
EIF3L	5539
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
EIF3D	5291
EIF3A	5270
EIF4H	5218
RPS9	5216
RPL18	5215
RPLP1	5137
EIF3G	5089
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
EIF3I	3667
EIF3B	3604
FAU	3409
RPS5	3240
EIF3F	3233
EIF3H	3034
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
EIF3K	1840
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
EIF4B	1330
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
EIF4A2	-418
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
EIF2S2	-1692
RPL26L1	-1755
EIF5	-1822
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
EIF3M	-2604
EIF2S3	-2635
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
EIF5B	-3535
EIF3E	-4214
EIF2S1	-4256
RPS7	-4550
EIF1AX	-4691
EIF4E	-5182
EIF3J	-5510
RPL36A	-5827
RPS26	-7408

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

	537
set	Influenza Viral RNA Transcription and Replication
setSize	134
pANOVA	4.69e-07
s.dist	0.252
p.adjustANOVA	1.61e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLR2A	6867
RPSA	6533
RPL36AL	6352
POLR2F	6141
PARP1	5971
RPS2	5798
RPLP2	5670
RPS15	5631
NUP62	5560
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
NUP88	5134
RPL13A	5043
UBA52	5032
RPL37A	4988

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLR2A	6867
RPSA	6533
RPL36AL	6352
POLR2F	6141
PARP1	5971
RPS2	5798
RPLP2	5670
RPS15	5631
NUP62	5560
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
NUP88	5134
RPL13A	5043
UBA52	5032
RPL37A	4988
NUP188	4942
NUP98	4904
RPL29	4856
RPL23A	4851
NUP160	4771
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
SEC13	4359
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
POLR2I	4168
TPR	4113
POM121	4042
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
NUP205	3685
POLR2L	3442
FAU	3409
RPS5	3240
POLR2E	3025
POM121C	2955
RPL30	2947
GTF2F1	2803
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
NUP93	2426
RPL12	2246
GRSF1	2207
RPS13	2004
POLR2H	1965
NUP155	1758
RPS18	1690
RPL23	1687
RPL31	1652
NUP133	1546
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
NUP214	1222
RAE1	1163
NUP85	1136
POLR2J	1069
RPL27A	1058
POLR2B	739
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
POLR2G	336
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
NUP153	90
RPL7	-2
RPS27A	-177
SEH1L	-247
POLR2C	-311
RPL26	-335
NUP35	-363
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
AAAS	-1069
RPS8	-1110
POLR2D	-1176
RPS4Y1	-1305
NUP107	-1364
RPL21	-1476
RPL26L1	-1755
NUP42	-1817
RPL6	-1834
RPL35A	-1915
RPL5	-2001
NUP50	-2132
RPS4X	-2225
RPS6	-2299
RPL11	-2374
IPO5	-2476
RPS3A	-2553
RPS25	-3129
RPL22	-3228
POLR2K	-3290
RPL22L1	-3463
RPL24	-3530
NUP43	-3666
HSP90AA1	-4069
NUP54	-4512
RPS7	-4550
NUP37	-5077
NUP210	-5199
NUP58	-5351
RPL36A	-5827
DNAJC3	-6166
RANBP2	-6291
NDC1	-7051
RPS26	-7408
GTF2F2	-8382

---

Interferon alpha/beta signaling

Interferon alpha/beta signaling

	559
set	Interferon alpha/beta signaling
setSize	56
pANOVA	7.18e-07
s.dist	0.383
p.adjustANOVA	2.41e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EGR1	7156
SOCS3	7146
MX1	7137
HLA-C	7108
OAS3	7086
IRF7	7015
IRF1	6973
OASL	6957
OAS2	6831
HLA-B	6686
IRF9	6669
IFIT1	6662
IFITM2	6611
RNASEL	6568
BST2	6482
IFIT2	6399
IFITM1	6269
IFI35	6194
HLA-E	6168
IFI27	6062

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EGR1	7156
SOCS3	7146
MX1	7137
HLA-C	7108
OAS3	7086
IRF7	7015
IRF1	6973
OASL	6957
OAS2	6831
HLA-B	6686
IRF9	6669
IFIT1	6662
IFITM2	6611
RNASEL	6568
BST2	6482
IFIT2	6399
IFITM1	6269
IFI35	6194
HLA-E	6168
IFI27	6062
MX2	6054
PSMB8	5892
ADAR	5872
IFITM3	5834
JAK1	5471
IFIT3	5451
IFI6	5432
USP18	5280
RSAD2	4840
IP6K2	4192
PTPN1	3603
STAT1	3337
TYK2	3117
OAS1	2953
STAT2	2667
HLA-F	2407
XAF1	2283
HLA-A	2271
PTPN6	-210
ISG15	-1199
IFNAR2	-1235
IRF3	-2310
HLA-H	-2484
IRF6	-3869
IFNAR1	-4438
ABCE1	-4725
IFIT5	-4846
PTPN11	-5259
IRF4	-5702
SOCS1	-5767
IRF2	-6421
GBP2	-6527
IRF8	-7082
ISG20	-7388
IRF5	-7498
SAMHD1	-7625

---

Peptide chain elongation

Peptide chain elongation

	814
set	Peptide chain elongation
setSize	87
pANOVA	7.84e-07
s.dist	0.306
p.adjustANOVA	2.57e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
EEF2	4907
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
EEF2	4907
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
FAU	3409
RPS5	3240
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
EEF1A1	-1696
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
RPS7	-4550
RPL36A	-5827
RPS26	-7408

---

Signaling by ROBO receptors

Signaling by ROBO receptors

	1178
set	Signaling by ROBO receptors
setSize	202
pANOVA	9.88e-07
s.dist	0.2
p.adjustANOVA	3.17e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBB	7069
UBC	7001
PSMB3	6540
RPSA	6533
PAK1	6509
EIF4A3	6413
RPL36AL	6352
ROBO1	6242
PSMD3	6058
PSMD1	5956
PSMB5	5903
PSMB8	5892
RPS2	5798
ARHGAP39	5746
RPLP2	5670
RPS15	5631
NCK2	5545
RPS11	5527
RPS3	5509
PSMB9	5506

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBB	7069
UBC	7001
PSMB3	6540
RPSA	6533
PAK1	6509
EIF4A3	6413
RPL36AL	6352
ROBO1	6242
PSMD3	6058
PSMD1	5956
PSMB5	5903
PSMB8	5892
RPS2	5798
ARHGAP39	5746
RPLP2	5670
RPS15	5631
NCK2	5545
RPS11	5527
RPS3	5509
PSMB9	5506
RPL9	5484
EIF4G1	5479
RPL19	5434
PSMC3	5388
PSMD2	5344
PSMB6	5343
SRC	5289
RPS9	5216
RPL18	5215
SLIT3	5141
RPLP1	5137
ELOB	5136
RPL13A	5043
PSMD4	5037
UBA52	5032
PSME2	5022
PSMD8	5019
PSMB4	4992
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
ZSWIM8	4646
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
PAK4	4228
PSMC4	4202
GSPT2	4044
PSMC5	4020
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
CAP2	3621
GPC1	3507
FAU	3409
PSMB10	3266
RPS5	3240
PSMB7	3031
RPL30	2947
PSMC1	2778
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
PSMA5	2400
RPL12	2246
ELOC	2152
PSMC2	2124
UPF2	2033
RPS13	2004
RBX1	1898
PSMB2	1820
PSMB1	1804
PSMA7	1752
RPS18	1690
RPL23	1687
RPL31	1652
SLIT1	1643
MAGOH	1590
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
ABL1	1363
RPL10	1356
CXCR4	1350
PSMD7	1338
RPS23	1326
RPS20	1305
LDB1	1245
PSMD9	1114
PSMA1	1108
RPL27A	1058
PSMD13	1057
PRKACA	933
SLIT2	875
CAP1	849
PSMD6	790
NCK1	742
PSMF1	734
CASC3	674
PFN1	627
PSME1	622
NRP1	566
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RNPS1	144
RPL7	-2
PSMA2	-124
RPS27A	-177
RPL26	-335
RHOA	-387
CLASP1	-395
PSMA6	-423
VASP	-447
RPL10A	-551
RPS17	-616
RAC1	-651
RPL17	-661
PSMD11	-674
SRGAP1	-791
PSMD5	-792
SOS2	-819
RPS24	-856
PPP3CB	-967
RBM8A	-1037
RPS8	-1110
PFN2	-1187
COL4A5	-1242
NCBP2	-1265
RPS4Y1	-1305
SEM1	-1355
PSMD14	-1462
RPL21	-1476
EVL	-1571
PSME3	-1684
RPL26L1	-1755
UPF3B	-1799
RPL6	-1834
RPL35A	-1915
DAG1	-1926
RPL5	-2001
PSMC6	-2073
MYO9B	-2121
PSMA4	-2141
RPS4X	-2225
RPS6	-2299
RPL11	-2374
UPF3A	-2450
RPS3A	-2553
SRGAP2	-2601
GSPT1	-2996
RPS25	-3129
RPL22	-3228
PRKAR2A	-3291
RPL22L1	-3463
RPL24	-3530
CLASP2	-3540
ETF1	-3636
PSMA3	-3674
NCBP1	-4287
PSMD10	-4314
ABL2	-4397
PSMD12	-4430
PABPC1	-4540
RPS7	-4550
CXCL12	-4878
MAGOHB	-4885
PAK6	-5101
CUL2	-5250
PAK2	-5599
SRGAP3	-5625
RPL36A	-5827
ENAH	-5841
CDC42	-5909
PSME4	-6160
ROBO3	-6170
FLRT3	-6285
SOS1	-6323
USP33	-6398
PRKCA	-6547
PAK3	-6715
LHX4	-6874
RPS26	-7408
NELL2	-7844
PRKACB	-7886
NTN1	-7919

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

	1404
set	rRNA processing in the nucleus and cytosol
setSize	189
pANOVA	1.24e-06
s.dist	0.205
p.adjustANOVA	3.87e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NOB1	6721
RPSA	6533
NOP56	6500
RRP7A	6455
RPL36AL	6352
NAT10	5973
RRP1	5882
RPS2	5798
NOC4L	5740
RPLP2	5670
NCL	5641
RPS15	5631
BYSL	5616
FBL	5583
RPP21	5581
RPS11	5527
RPS3	5509
RPL9	5484
PELP1	5454
RPL19	5434

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NOB1	6721
RPSA	6533
NOP56	6500
RRP7A	6455
RPL36AL	6352
NAT10	5973
RRP1	5882
RPS2	5798
NOC4L	5740
RPLP2	5670
NCL	5641
RPS15	5631
BYSL	5616
FBL	5583
RPP21	5581
RPS11	5527
RPS3	5509
RPL9	5484
PELP1	5454
RPL19	5434
EXOSC10	5261
RPS9	5216
RPL18	5215
LAS1L	5214
RPLP1	5137
PES1	5074
RPL13A	5043
UBA52	5032
PDCD11	5031
UTP3	5008
RPL37A	4988
IMP4	4971
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
TBL3	4732
BMS1	4629
RPS28	4590
EXOSC5	4553
RPL28	4548
FTSJ3	4541
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
NHP2	4147
TSR1	4137
DDX49	4136
WDR3	3995
RIOK1	3861
RPL41	3826
RPL8	3810
RPL36	3737
EMG1	3716
RPLP0	3705
WDR18	3594
EXOSC4	3577
FAU	3409
RPS5	3240
CSNK1D	3222
RRP9	3191
NOL6	3082
NOP2	3064
RPL30	2947
RPS29	2765
SNU13	2710
RPS21	2509
RPL7A	2493
TRMT112	2470
RPL13	2437
RPL12	2246
DKC1	2235
NOP10	2210
NOP14	2174
RPS13	2004
EBNA1BP2	1940
IMP3	1813
BOP1	1733
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
EXOSC1	1359
RPL10	1356
GNL3	1331
RPS23	1326
RPS20	1305
HEATR1	1299
UTP20	1284
RCL1	1137
RPL27A	1058
EXOSC2	1035
PNO1	987
UTP14A	828
XRN2	787
RIOK2	762
MPHOSPH6	625
MPHOSPH10	618
UTP4	587
DDX47	585
GAR1	568
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
LTV1	165
UTP18	151
RPS27L	146
RPL7	-2
WDR46	-24
DHX37	-159
RPS27A	-177
TSR3	-281
RPL26	-335
ISG20L2	-516
RPL10A	-551
RPS17	-616
RPL17	-661
CSNK1E	-692
UTP25	-807
RPS24	-856
RPS8	-1110
NOL9	-1148
NIP7	-1233
RPS4Y1	-1305
RPL21	-1476
WDR43	-1660
RPP30	-1749
RPL26L1	-1755
RPL6	-1834
RPP38	-1912
RPL35A	-1915
RPL5	-2001
UTP15	-2083
RRP36	-2085
RPS4X	-2225
RPS6	-2299
UTP6	-2341
RPL11	-2374
NOL11	-2505
DIS3	-2531
RPS3A	-2553
WDR75	-2802
NOL12	-2845
RPP14	-3047
RBM28	-3115
RPS25	-3129
RPL22	-3228
THUMPD1	-3334
RPL22L1	-3463
RPP25	-3464
RPL24	-3530
MTREX	-3560
RIOK3	-3677
UTP11	-3689
DDX52	-3774
FCF1	-3920
WDR12	-4090
NOP58	-4217
EXOSC9	-4334
SENP3	-4374
DDX21	-4531
RPS7	-4550
EXOSC8	-4755
DIMT1	-4887
EXOSC3	-5079
TEX10	-5212
RPP40	-5654
RPL36A	-5827
KRR1	-5948
ERI1	-6093
C1D	-6214
WDR36	-7214
DCAF13	-7300
RPS26	-7408
UTP14C	-7565
EXOSC6	-8109
EXOSC7	-8489
PWP2	-8653

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	362
set	Eukaryotic Translation Termination
setSize	91
pANOVA	1.52e-06
s.dist	0.292
p.adjustANOVA	4.67e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
GSPT2	4044
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
APEH	3692
FAU	3409
RPS5	3240
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
TRMT112	2470
RPL13	2437
RPL12	2246
RPS13	2004
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
GSPT1	-2996
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
ETF1	-3636
N6AMT1	-4412
RPS7	-4550
RPL36A	-5827
RPS26	-7408

---

Influenza Infection

Influenza Infection

	536
set	Influenza Infection
setSize	153
pANOVA	1.63e-06
s.dist	0.225
p.adjustANOVA	4.89e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HSPA1A	7054
POLR2A	6867
RPSA	6533
RPL36AL	6352
POLR2F	6141
PARP1	5971
RPS2	5798
RPLP2	5670
RPS15	5631
NUP62	5560
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
NUP88	5134
RPL13A	5043
UBA52	5032

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HSPA1A	7054
POLR2A	6867
RPSA	6533
RPL36AL	6352
POLR2F	6141
PARP1	5971
RPS2	5798
RPLP2	5670
RPS15	5631
NUP62	5560
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
NUP88	5134
RPL13A	5043
UBA52	5032
RPL37A	4988
NUP188	4942
NUP98	4904
RPL29	4856
RPL23A	4851
KPNB1	4828
NUP160	4771
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
CPSF4	4410
SEC13	4359
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
POLR2I	4168
TPR	4113
POM121	4042
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
NUP205	3685
POLR2L	3442
FAU	3409
RPS5	3240
POLR2E	3025
POM121C	2955
RPL30	2947
CLTA	2934
GTF2F1	2803
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
NUP93	2426
RPL12	2246
GRSF1	2207
RPS13	2004
POLR2H	1965
NUP155	1758
PABPN1	1738
RPS18	1690
RPL23	1687
RPL31	1652
NUP133	1546
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RAN	1342
RPS23	1326
RPS20	1305
NUP214	1222
CALR	1213
RAE1	1163
NUP85	1136
SLC25A6	1117
POLR2J	1069
RPL27A	1058
POLR2B	739
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
POLR2G	336
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
NUP153	90
RPL7	-2
CANX	-68
RPS27A	-177
SEH1L	-247
POLR2C	-311
RPL26	-335
CLTC	-338
NUP35	-363
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
AAAS	-1069
RPS8	-1110
KPNA2	-1121
POLR2D	-1176
ISG15	-1199
RPS4Y1	-1305
NUP107	-1364
RPL21	-1476
RPL26L1	-1755
NUP42	-1817
RPL6	-1834
RPL35A	-1915
RPL5	-2001
NUP50	-2132
RPS4X	-2225
RPS6	-2299
RPL11	-2374
IPO5	-2476
RPS3A	-2553
RPS25	-3129
RPL22	-3228
POLR2K	-3290
RPL22L1	-3463
KPNA1	-3500
RPL24	-3530
NUP43	-3666
KPNA4	-4049
HSP90AA1	-4069
KPNA5	-4183
EIF2AK2	-4248
NUP54	-4512
RPS7	-4550
TGFB1	-4611
NUP37	-5077
NUP210	-5199
NUP58	-5351
XPO1	-5416
RPL36A	-5827
DNAJC3	-6166
KPNA3	-6275
RANBP2	-6291
NDC1	-7051
RPS26	-7408
GTF2F2	-8382

---

Interferon Signaling

Interferon Signaling

	558
set	Interferon Signaling
setSize	173
pANOVA	1.73e-06
s.dist	0.211
p.adjustANOVA	5.08e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EGR1	7156
SOCS3	7146
MX1	7137
NCAM1	7122
HLA-C	7108
OAS3	7086
UBB	7069
IRF7	7015
UBC	7001
IRF1	6973
OASL	6957
OAS2	6831
HLA-DRB5	6778
HLA-B	6686
IRF9	6669
IFIT1	6662
IFITM2	6611
GBP1	6600
RNASEL	6568
TRIM62	6519

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EGR1	7156
SOCS3	7146
MX1	7137
NCAM1	7122
HLA-C	7108
OAS3	7086
UBB	7069
IRF7	7015
UBC	7001
IRF1	6973
OASL	6957
OAS2	6831
HLA-DRB5	6778
HLA-B	6686
IRF9	6669
IFIT1	6662
IFITM2	6611
GBP1	6600
RNASEL	6568
TRIM62	6519
BST2	6482
EIF4A3	6413
IFIT2	6399
IFITM1	6269
EIF4E2	6210
IFI35	6194
ICAM1	6175
HLA-E	6168
MT2A	6149
EIF4A1	6142
HLA-DRB1	6085
IFI27	6062
MX2	6054
TRIM21	5978
PML	5894
PSMB8	5892
TRIM68	5880
ADAR	5872
IFITM3	5834
NUP62	5560
EIF4G1	5479
JAK1	5471
IFIT3	5451
IFI6	5432
HLA-DPA1	5394
USP18	5280
UBE2L6	5139
NUP88	5134
TRIM3	5046
UBA52	5032
GBP4	5030
NUP188	4942
TRIM26	4930
NUP98	4904
GBP5	4846
RSAD2	4840
KPNB1	4828
NUP160	4771
TRIM45	4703
UBA7	4675
GBP3	4426
HLA-DQA2	4405
SEC13	4359
TRIM22	4284
IP6K2	4192
TPR	4113
POM121	4042
MAPK3	3978
FLNB	3863
CAMK2B	3811
HLA-DPB1	3725
TRIM8	3713
NUP205	3685
PTPN1	3603
PLCG1	3502
STAT1	3337
TRIM35	3223
TYK2	3117
FLNA	2981
POM121C	2955
OAS1	2953
STAT2	2667
PIN1	2585
NUP93	2426
HLA-F	2407
MID1	2285
XAF1	2283
HLA-A	2271
HLA-DRA	1947
EIF4G3	1907
NUP155	1758
NUP133	1546
TRIM34	1465
NUP214	1222
RAE1	1163
CIITA	1139
NUP85	1136
TRIM5	800
CAMK2G	347
IFNGR2	226
UBE2E1	155
NUP153	90
TRIM25	27
RPS27A	-177
PTPN6	-210
EIF4G2	-212
SEH1L	-247
NUP35	-363
EIF4A2	-418
AAAS	-1069
KPNA2	-1121
ISG15	-1199
IFNAR2	-1235
NUP107	-1364
PTPN2	-1499
NUP42	-1817
NUP50	-2132
HERC5	-2140
IRF3	-2310
TRIM14	-2480
HLA-H	-2484
PTAFR	-3117
ARIH1	-3404
CAMK2D	-3485
KPNA1	-3500
NUP43	-3666
TRIM38	-3814
IRF6	-3869
KPNA4	-4049
HLA-DQA1	-4161
KPNA5	-4183
EIF2AK2	-4248
B2M	-4394
IFNAR1	-4438
NUP54	-4512
ABCE1	-4725
PIAS1	-4816
IFIT5	-4846
DDX58	-4880
SUMO1	-4881
NUP37	-5077
PPM1B	-5136
SP100	-5174
EIF4E	-5182
NUP210	-5199
PTPN11	-5259
NUP58	-5351
IFI30	-5419
PRKCD	-5561
IRF4	-5702
UBE2N	-5703
SOCS1	-5767
CAMK2A	-6259
KPNA3	-6275
RANBP2	-6291
EIF4E3	-6373
IRF2	-6421
GBP2	-6527
IFNGR1	-6536
VCAM1	-6848
NDC1	-7051
HLA-DQB1	-7064
IRF8	-7082
JAK2	-7193
ISG20	-7388
PDE12	-7478
IRF5	-7498
SAMHD1	-7625
TRIM29	-8137
NEDD4	-8250
CD44	-8311
TRIM10	-8471
TRIM2	-8530

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	749
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	93
pANOVA	1.77e-06
s.dist	0.287
p.adjustANOVA	5.09e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
UPF1	5791
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
UPF1	5791
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
EIF4G1	5479
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
GSPT2	4044
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
FAU	3409
RPS5	3240
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
RPS13	2004
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
NCBP2	-1265
RPS4Y1	-1305
RPL21	-1476
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
GSPT1	-2996
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
ETF1	-3636
NCBP1	-4287
PABPC1	-4540
RPS7	-4550
RPL36A	-5827
RPS26	-7408

---

Viral mRNA Translation

Viral mRNA Translation

	1363
set	Viral mRNA Translation
setSize	87
pANOVA	1.83e-06
s.dist	0.296
p.adjustANOVA	5.17e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPSA	6533
RPL36AL	6352
RPS2	5798
RPLP2	5670
RPS15	5631
RPS11	5527
RPS3	5509
RPL9	5484
RPL19	5434
RPS9	5216
RPL18	5215
RPLP1	5137
RPL13A	5043
UBA52	5032
RPL37A	4988
RPL29	4856
RPL23A	4851
RPS19	4757
RPL38	4753
RPS16	4751
RPS28	4590
RPL28	4548
RPL3L	4465
RPL14	4354
RPS15A	4345
RPL37	4334
RPL32	4253
RPL41	3826
RPL8	3810
RPL36	3737
RPLP0	3705
FAU	3409
RPS5	3240
RPL30	2947
RPS29	2765
RPS21	2509
RPL7A	2493
RPL13	2437
RPL12	2246
GRSF1	2207
RPS13	2004
RPS18	1690
RPL23	1687
RPL31	1652
RPL18A	1485
RPS10	1452
RPS14	1447
RPL27	1373
RPL10	1356
RPS23	1326
RPS20	1305
RPL27A	1058
RPL4	516
RPL15	466
RPL35	420
RPS12	414
RPL34	379
RPS27	304
RPL39	225
RPL3	207
RPS27L	146
RPL7	-2
RPS27A	-177
RPL26	-335
RPL10A	-551
RPS17	-616
RPL17	-661
RPS24	-856
RPS8	-1110
RPS4Y1	-1305
RPL21	-1476
RPL26L1	-1755
RPL6	-1834
RPL35A	-1915
RPL5	-2001
RPS4X	-2225
RPS6	-2299
RPL11	-2374
RPS3A	-2553
RPS25	-3129
RPL22	-3228
RPL22L1	-3463
RPL24	-3530
RPS7	-4550
RPL36A	-5827
DNAJC3	-6166
RPS26	-7408

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.0 (2022-04-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] beeswarm_0.4.0              gtools_3.9.2               
##  [5] echarts4r_0.4.3             kableExtra_1.3.4           
##  [7] topconfects_1.8.0           limma_3.48.3               
##  [9] eulerr_6.1.1                mitch_1.4.1                
## [11] MASS_7.3-56                 fgsea_1.18.0               
## [13] gplots_3.1.1                DESeq2_1.32.0              
## [15] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [17] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [19] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [21] IRanges_2.26.0              S4Vectors_0.30.2           
## [23] BiocGenerics_0.38.0         reshape2_1.4.4             
## [25] forcats_0.5.1               stringr_1.4.0              
## [27] dplyr_1.0.8                 purrr_0.3.4                
## [29] readr_2.1.2                 tidyr_1.2.0                
## [31] tibble_3.1.6                ggplot2_3.3.5              
## [33] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-3       ellipsis_0.3.2         rprojroot_2.0.2       
##   [4] XVector_0.32.0         fs_1.5.2               rstudioapi_0.13       
##   [7] bit64_4.0.5            AnnotationDbi_1.54.1   fansi_1.0.2           
##  [10] lubridate_1.8.0        xml2_1.3.3             splines_4.2.0         
##  [13] cachem_1.0.6           geneplotter_1.70.0     knitr_1.37            
##  [16] jsonlite_1.8.0         broom_0.7.12           annotate_1.70.0       
##  [19] dbplyr_2.1.1           png_0.1-7              shiny_1.7.1           
##  [22] compiler_4.2.0         httr_1.4.2             backports_1.4.1       
##  [25] assertthat_0.2.1       Matrix_1.4-1           fastmap_1.1.0         
##  [28] cli_3.2.0              later_1.3.0            htmltools_0.5.2       
##  [31] tools_4.2.0            gtable_0.3.0           glue_1.6.2            
##  [34] GenomeInfoDbData_1.2.6 fastmatch_1.1-3        Rcpp_1.0.8.2          
##  [37] cellranger_1.1.0       jquerylib_0.1.4        vctrs_0.3.8           
##  [40] Biostrings_2.60.2      svglite_2.1.0          xfun_0.30             
##  [43] rvest_1.0.2            mime_0.12              lifecycle_1.0.1       
##  [46] XML_3.99-0.9           zlibbioc_1.38.0        scales_1.1.1          
##  [49] promises_1.2.0.1       hms_1.1.1              RColorBrewer_1.1-2    
##  [52] yaml_2.3.5             gridExtra_2.3          memoise_2.0.1         
##  [55] sass_0.4.0             reshape_0.8.8          stringi_1.7.6         
##  [58] RSQLite_2.2.10         highr_0.9              genefilter_1.74.1     
##  [61] desc_1.4.1             caTools_1.18.2         BiocParallel_1.26.2   
##  [64] systemfonts_1.0.4      rlang_1.0.2            pkgconfig_2.0.3       
##  [67] bitops_1.0-7           evaluate_0.15          lattice_0.20-45       
##  [70] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.1.2      
##  [73] plyr_1.8.6             magrittr_2.0.2         R6_2.5.1              
##  [76] generics_0.1.2         DelayedArray_0.18.0    DBI_1.1.2             
##  [79] pillar_1.7.0           haven_2.4.3            withr_2.5.0           
##  [82] survival_3.3-1         KEGGREST_1.32.0        RCurl_1.98-1.6        
##  [85] modelr_0.1.8           crayon_1.5.0           KernSmooth_2.23-20    
##  [88] utf8_1.2.2             tzdb_0.2.0             rmarkdown_2.13        
##  [91] locfit_1.5-9.5         grid_4.2.0             readxl_1.3.1          
##  [94] data.table_1.14.2      blob_1.2.2             webshot_0.5.2         
##  [97] reprex_2.0.1           digest_0.6.29          xtable_1.8-4          
## [100] httpuv_1.6.5           munsell_0.5.0          viridisLite_0.4.0     
## [103] bslib_0.3.1

END of report