date generated: 2024-03-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -3.451453
7SK -1.426939
A1BG 1.529759
A1BG.AS1 1.877187
A2M -1.546889
A2M.AS1 -1.368094

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 16550
duplicated_genes_present 0
num_profile_genes_in_sets 8303
num_profile_genes_not_in_sets 8247

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1150
num_genesets_included 1462

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 1.02e-05 -0.806 1.78e-04
Citric acid cycle (TCA cycle) 22 4.73e-10 -0.767 2.39e-08
Glyoxylate metabolism and glycine degradation 23 1.93e-10 -0.767 1.13e-08
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.12e-04 -0.706 1.28e-03
Branched-chain amino acid catabolism 21 5.04e-08 -0.687 1.42e-06
Zinc transporters 10 1.69e-04 0.687 1.69e-03
Complex I biogenesis 51 8.21e-17 -0.674 1.09e-14
Mucopolysaccharidoses 11 1.16e-04 0.671 1.29e-03
Dissolution of Fibrin Clot 10 2.84e-04 0.663 2.46e-03
Respiratory electron transport 93 8.63e-27 -0.642 4.21e-24
Diseases associated with N-glycosylation of proteins 20 8.79e-07 0.635 1.92e-05
Formation of ATP by chemiosmotic coupling 16 1.15e-05 -0.633 1.96e-04
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 6.36e-31 -0.629 4.65e-28
The citric acid (TCA) cycle and respiratory electron transport 160 4.58e-41 -0.614 6.70e-38
CS/DS degradation 11 4.30e-04 0.613 3.45e-03
The activation of arylsulfatases 10 1.11e-03 0.596 7.32e-03
Glycogen synthesis 13 2.09e-04 -0.594 1.96e-03
Pyruvate metabolism and Citric Acid (TCA) cycle 51 2.76e-13 -0.591 2.52e-11
Syndecan interactions 26 3.93e-07 0.575 9.27e-06
Carnitine metabolism 14 2.14e-04 -0.571 1.99e-03
Striated Muscle Contraction 34 9.96e-09 -0.568 3.17e-07
ADP signalling through P2Y purinoceptor 12 15 1.92e-04 0.556 1.85e-03
Mitochondrial calcium ion transport 22 7.15e-06 -0.553 1.32e-04
Regulation of pyruvate dehydrogenase (PDH) complex 15 2.82e-04 -0.542 2.46e-03
Chondroitin sulfate biosynthesis 15 2.93e-04 0.540 2.50e-03
Scavenging by Class A Receptors 16 1.86e-04 0.540 1.81e-03
Mitochondrial translation 94 7.05e-19 -0.529 1.47e-16
Mitochondrial translation elongation 88 1.33e-17 -0.527 2.42e-15
Trafficking and processing of endosomal TLR 12 1.60e-03 0.526 1.02e-02
G beta:gamma signalling through BTK 13 1.06e-03 0.524 7.12e-03
Processing of SMDT1 15 4.45e-04 -0.524 3.54e-03
Signaling by Leptin 11 2.64e-03 -0.524 1.53e-02
Cristae formation 29 1.08e-06 -0.523 2.28e-05
Mitochondrial translation termination 88 2.82e-17 -0.521 4.59e-15
Mitochondrial translation initiation 88 3.79e-17 -0.519 5.55e-15
Beta-oxidation of very long chain fatty acids 10 4.49e-03 -0.519 2.34e-02
Metal ion SLC transporters 18 1.90e-04 0.508 1.84e-03
RHO GTPases activate IQGAPs 23 3.51e-05 0.498 5.04e-04
Keratan sulfate degradation 13 1.91e-03 0.497 1.17e-02
Degradation of cysteine and homocysteine 14 1.42e-03 -0.492 9.11e-03
Regulation of FOXO transcriptional activity by acetylation 10 7.03e-03 -0.492 3.29e-02
FOXO-mediated transcription of cell death genes 15 1.11e-03 -0.486 7.32e-03
Chondroitin sulfate/dermatan sulfate metabolism 43 3.86e-08 0.484 1.11e-06
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 2.84e-03 0.478 1.63e-02
Leading Strand Synthesis 14 2.01e-03 0.477 1.21e-02
Polymerase switching 14 2.01e-03 0.477 1.21e-02
Signal regulatory protein family interactions 11 6.35e-03 0.475 3.12e-02
Mitochondrial Fatty Acid Beta-Oxidation 34 1.70e-06 -0.474 3.36e-05
Prolactin receptor signaling 10 1.05e-02 -0.467 4.55e-02
FCGR activation 11 7.44e-03 0.466 3.43e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 1.02e-05 -8.06e-01 1.78e-04
Citric acid cycle (TCA cycle) 22 4.73e-10 -7.67e-01 2.39e-08
Glyoxylate metabolism and glycine degradation 23 1.93e-10 -7.67e-01 1.13e-08
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.12e-04 -7.06e-01 1.28e-03
Branched-chain amino acid catabolism 21 5.04e-08 -6.87e-01 1.42e-06
Zinc transporters 10 1.69e-04 6.87e-01 1.69e-03
Complex I biogenesis 51 8.21e-17 -6.74e-01 1.09e-14
Mucopolysaccharidoses 11 1.16e-04 6.71e-01 1.29e-03
Dissolution of Fibrin Clot 10 2.84e-04 6.63e-01 2.46e-03
Respiratory electron transport 93 8.63e-27 -6.42e-01 4.21e-24
Diseases associated with N-glycosylation of proteins 20 8.79e-07 6.35e-01 1.92e-05
Formation of ATP by chemiosmotic coupling 16 1.15e-05 -6.33e-01 1.96e-04
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 6.36e-31 -6.29e-01 4.65e-28
The citric acid (TCA) cycle and respiratory electron transport 160 4.58e-41 -6.14e-01 6.70e-38
CS/DS degradation 11 4.30e-04 6.13e-01 3.45e-03
The activation of arylsulfatases 10 1.11e-03 5.96e-01 7.32e-03
Glycogen synthesis 13 2.09e-04 -5.94e-01 1.96e-03
Pyruvate metabolism and Citric Acid (TCA) cycle 51 2.76e-13 -5.91e-01 2.52e-11
Syndecan interactions 26 3.93e-07 5.75e-01 9.27e-06
Carnitine metabolism 14 2.14e-04 -5.71e-01 1.99e-03
Striated Muscle Contraction 34 9.96e-09 -5.68e-01 3.17e-07
ADP signalling through P2Y purinoceptor 12 15 1.92e-04 5.56e-01 1.85e-03
Mitochondrial calcium ion transport 22 7.15e-06 -5.53e-01 1.32e-04
Regulation of pyruvate dehydrogenase (PDH) complex 15 2.82e-04 -5.42e-01 2.46e-03
Chondroitin sulfate biosynthesis 15 2.93e-04 5.40e-01 2.50e-03
Scavenging by Class A Receptors 16 1.86e-04 5.40e-01 1.81e-03
Mitochondrial translation 94 7.05e-19 -5.29e-01 1.47e-16
Mitochondrial translation elongation 88 1.33e-17 -5.27e-01 2.42e-15
Trafficking and processing of endosomal TLR 12 1.60e-03 5.26e-01 1.02e-02
G beta:gamma signalling through BTK 13 1.06e-03 5.24e-01 7.12e-03
Processing of SMDT1 15 4.45e-04 -5.24e-01 3.54e-03
Signaling by Leptin 11 2.64e-03 -5.24e-01 1.53e-02
Cristae formation 29 1.08e-06 -5.23e-01 2.28e-05
Mitochondrial translation termination 88 2.82e-17 -5.21e-01 4.59e-15
Mitochondrial translation initiation 88 3.79e-17 -5.19e-01 5.55e-15
Beta-oxidation of very long chain fatty acids 10 4.49e-03 -5.19e-01 2.34e-02
Metal ion SLC transporters 18 1.90e-04 5.08e-01 1.84e-03
RHO GTPases activate IQGAPs 23 3.51e-05 4.98e-01 5.04e-04
Keratan sulfate degradation 13 1.91e-03 4.97e-01 1.17e-02
Degradation of cysteine and homocysteine 14 1.42e-03 -4.92e-01 9.11e-03
Regulation of FOXO transcriptional activity by acetylation 10 7.03e-03 -4.92e-01 3.29e-02
FOXO-mediated transcription of cell death genes 15 1.11e-03 -4.86e-01 7.32e-03
Chondroitin sulfate/dermatan sulfate metabolism 43 3.86e-08 4.84e-01 1.11e-06
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 2.84e-03 4.78e-01 1.63e-02
Leading Strand Synthesis 14 2.01e-03 4.77e-01 1.21e-02
Polymerase switching 14 2.01e-03 4.77e-01 1.21e-02
Signal regulatory protein family interactions 11 6.35e-03 4.75e-01 3.12e-02
Mitochondrial Fatty Acid Beta-Oxidation 34 1.70e-06 -4.74e-01 3.36e-05
Prolactin receptor signaling 10 1.05e-02 -4.67e-01 4.55e-02
FCGR activation 11 7.44e-03 4.66e-01 3.43e-02
Mitochondrial protein import 63 1.64e-10 -4.66e-01 1.01e-08
Mitochondrial iron-sulfur cluster biogenesis 13 3.72e-03 -4.65e-01 2.05e-02
HSF1-dependent transactivation 33 4.11e-06 -4.63e-01 7.80e-05
RHO GTPases Activate WASPs and WAVEs 36 1.54e-06 4.63e-01 3.09e-05
FCGR3A-mediated phagocytosis 58 1.90e-09 4.56e-01 7.32e-08
Leishmania phagocytosis 58 1.90e-09 4.56e-01 7.32e-08
Parasite infection 58 1.90e-09 4.56e-01 7.32e-08
Impaired BRCA2 binding to PALB2 23 1.76e-04 4.52e-01 1.74e-03
Lysine catabolism 11 9.54e-03 -4.51e-01 4.19e-02
Unwinding of DNA 12 6.95e-03 4.50e-01 3.28e-02
Caspase activation via Death Receptors in the presence of ligand 15 2.66e-03 4.48e-01 1.54e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 1.51e-04 4.47e-01 1.52e-03
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 1.51e-04 4.47e-01 1.52e-03
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 24 1.51e-04 4.47e-01 1.52e-03
Defective homologous recombination repair (HRR) due to PALB2 loss of function 24 1.51e-04 4.47e-01 1.52e-03
Interleukin-10 signaling 31 1.67e-05 4.47e-01 2.69e-04
Retrograde neurotrophin signalling 12 7.64e-03 4.45e-01 3.50e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 7.66e-03 4.45e-01 3.50e-02
Glycogen storage diseases 14 4.00e-03 -4.44e-01 2.15e-02
Gap junction degradation 12 8.01e-03 4.42e-01 3.63e-02
Advanced glycosylation endproduct receptor signaling 11 1.18e-02 4.39e-01 4.98e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 32 1.78e-05 4.38e-01 2.72e-04
Peroxisomal protein import 57 1.16e-08 -4.37e-01 3.60e-07
Hyaluronan uptake and degradation 11 1.27e-02 4.34e-01 5.25e-02
Pyruvate metabolism 27 9.46e-05 -4.34e-01 1.13e-03
G beta:gamma signalling through PLC beta 15 3.63e-03 4.34e-01 2.01e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 1.35e-04 4.33e-01 1.42e-03
Resolution of D-Loop Structures 33 1.72e-05 4.32e-01 2.72e-04
Condensation of Prometaphase Chromosomes 11 1.34e-02 4.30e-01 5.52e-02
VEGFR2 mediated cell proliferation 19 1.17e-03 4.30e-01 7.62e-03
Prostacyclin signalling through prostacyclin receptor 14 5.33e-03 4.30e-01 2.72e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 5.47e-03 4.29e-01 2.77e-02
Formation of annular gap junctions 11 1.39e-02 4.28e-01 5.68e-02
Pexophagy 11 1.41e-02 -4.27e-01 5.72e-02
Thrombin signalling through proteinase activated receptors (PARs) 25 2.20e-04 4.27e-01 2.03e-03
Peroxisomal lipid metabolism 26 1.68e-04 -4.26e-01 1.69e-03
Elastic fibre formation 41 2.54e-06 4.25e-01 4.89e-05
Post-translational protein phosphorylation 77 1.66e-10 4.21e-01 1.01e-08
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 8.91e-03 4.19e-01 3.95e-02
Phase 0 - rapid depolarisation 26 2.37e-04 -4.17e-01 2.18e-03
G beta:gamma signalling through PI3Kgamma 20 1.33e-03 4.14e-01 8.60e-03
Mitochondrial tRNA aminoacylation 21 1.05e-03 -4.13e-01 7.06e-03
Activation of kainate receptors upon glutamate binding 23 6.43e-04 4.11e-01 4.70e-03
Diseases associated with glycosaminoglycan metabolism 37 1.78e-05 4.08e-01 2.72e-04
Intraflagellar transport 48 1.24e-06 4.05e-01 2.55e-05
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 33 5.95e-05 4.04e-01 7.76e-04
Incretin synthesis, secretion, and inactivation 13 1.19e-02 4.03e-01 4.98e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 1.19e-02 4.03e-01 4.98e-02
Heme biosynthesis 12 1.61e-02 -4.01e-01 6.35e-02
DAP12 interactions 32 8.75e-05 4.01e-01 1.08e-03
COPI-dependent Golgi-to-ER retrograde traffic 84 2.38e-10 4.00e-01 1.29e-08
Presynaptic function of Kainate receptors 16 5.66e-03 4.00e-01 2.84e-02
Recycling pathway of L1 39 1.74e-05 3.98e-01 2.72e-04
Cardiogenesis 20 2.11e-03 -3.97e-01 1.26e-02
Glycogen metabolism 24 7.69e-04 -3.97e-01 5.41e-03
Regulation of actin dynamics for phagocytic cup formation 60 1.10e-07 3.96e-01 2.82e-06
The role of Nef in HIV-1 replication and disease pathogenesis 24 8.04e-04 3.95e-01 5.59e-03
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 1.79e-02 3.95e-01 6.89e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 86 2.86e-10 3.93e-01 1.49e-08
DNA strand elongation 32 1.21e-04 3.93e-01 1.32e-03
RUNX3 regulates p14-ARF 10 3.28e-02 3.90e-01 1.11e-01
Sulfur amino acid metabolism 25 7.62e-04 -3.89e-01 5.41e-03
Gastrin-CREB signalling pathway via PKC and MAPK 16 7.41e-03 3.87e-01 3.43e-02
LDL clearance 17 5.89e-03 3.86e-01 2.93e-02
Mitochondrial biogenesis 87 8.51e-10 -3.81e-01 3.66e-08
Molecules associated with elastic fibres 34 1.30e-04 3.79e-01 1.39e-03
Collagen formation 81 3.86e-09 3.79e-01 1.38e-07
G beta:gamma signalling through CDC42 15 1.16e-02 3.77e-01 4.92e-02
Mitotic Telophase/Cytokinesis 13 1.87e-02 3.77e-01 7.12e-02
Kinesins 45 1.25e-05 3.76e-01 2.10e-04
Transport of connexons to the plasma membrane 13 1.89e-02 3.76e-01 7.15e-02
Collagen biosynthesis and modifying enzymes 61 3.81e-07 3.76e-01 9.14e-06
Protein localization 155 7.88e-16 -3.75e-01 9.61e-14
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 3.22e-02 -3.73e-01 1.09e-01
CD28 dependent Vav1 pathway 10 4.30e-02 3.70e-01 1.33e-01
Fcgamma receptor (FCGR) dependent phagocytosis 83 6.62e-09 3.68e-01 2.25e-07
Homologous DNA Pairing and Strand Exchange 41 4.57e-05 3.68e-01 6.19e-04
Signal amplification 26 1.18e-03 3.68e-01 7.62e-03
EPH-ephrin mediated repulsion of cells 46 1.68e-05 3.67e-01 2.69e-04
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 1.92e-03 -3.66e-01 1.17e-02
Hyaluronan metabolism 16 1.15e-02 3.65e-01 4.92e-02
Glycosaminoglycan metabolism 106 8.61e-11 3.65e-01 5.89e-09
Binding and Uptake of Ligands by Scavenger Receptors 32 3.57e-04 3.65e-01 2.99e-03
Thromboxane signalling through TP receptor 19 6.24e-03 3.62e-01 3.08e-02
ADP signalling through P2Y purinoceptor 1 20 5.04e-03 3.62e-01 2.58e-02
Energy dependent regulation of mTOR by LKB1-AMPK 29 7.69e-04 -3.61e-01 5.41e-03
PINK1-PRKN Mediated Mitophagy 21 4.25e-03 -3.60e-01 2.24e-02
G-protein activation 18 8.15e-03 3.60e-01 3.68e-02
Platelet Adhesion to exposed collagen 11 3.96e-02 3.58e-01 1.25e-01
Lagging Strand Synthesis 20 5.62e-03 3.58e-01 2.83e-02
EPHB-mediated forward signaling 40 9.19e-05 3.57e-01 1.12e-03
Class I peroxisomal membrane protein import 20 5.74e-03 -3.57e-01 2.87e-02
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 1.17e-04 3.57e-01 1.29e-03
Diseases of DNA Double-Strand Break Repair 39 1.17e-04 3.57e-01 1.29e-03
GPVI-mediated activation cascade 31 6.05e-04 3.56e-01 4.49e-03
DARPP-32 events 23 3.37e-03 -3.53e-01 1.89e-02
ALK mutants bind TKIs 11 4.44e-02 3.50e-01 1.35e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 72 2.94e-07 3.50e-01 7.16e-06
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 18 1.03e-02 3.49e-01 4.47e-02
Presynaptic phase of homologous DNA pairing and strand exchange 38 1.96e-04 3.49e-01 1.86e-03
Deposition of new CENPA-containing nucleosomes at the centromere 30 9.38e-04 3.49e-01 6.38e-03
Nucleosome assembly 30 9.38e-04 3.49e-01 6.38e-03
CASP8 activity is inhibited 10 5.69e-02 3.48e-01 1.61e-01
Dimerization of procaspase-8 10 5.69e-02 3.48e-01 1.61e-01
Regulation by c-FLIP 10 5.69e-02 3.48e-01 1.61e-01
Regulated proteolysis of p75NTR 11 4.64e-02 3.47e-01 1.38e-01
Regulation of CDH11 gene transcription 10 5.92e-02 3.45e-01 1.65e-01
Mitophagy 28 1.70e-03 -3.43e-01 1.07e-02
Heparan sulfate/heparin (HS-GAG) metabolism 42 1.24e-04 3.42e-01 1.33e-03
Establishment of Sister Chromatid Cohesion 11 4.94e-02 3.42e-01 1.44e-01
Polymerase switching on the C-strand of the telomere 26 2.74e-03 3.39e-01 1.58e-02
Impaired BRCA2 binding to RAD51 33 7.48e-04 3.39e-01 5.35e-03
Resolution of Sister Chromatid Cohesion 110 8.30e-10 3.39e-01 3.66e-08
HS-GAG degradation 21 7.40e-03 3.38e-01 3.43e-02
Collagen degradation 53 2.16e-05 3.37e-01 3.22e-04
WNT5A-dependent internalization of FZD4 14 2.89e-02 3.37e-01 1.01e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.94e-02 3.36e-01 1.02e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 12 4.42e-02 3.36e-01 1.35e-01
Maturation of spike protein 9694548 37 4.26e-04 3.35e-01 3.44e-03
Interconversion of nucleotide di- and triphosphates 27 2.64e-03 3.34e-01 1.53e-02
G-protein beta:gamma signalling 27 3.08e-03 3.29e-01 1.74e-02
Metabolism of cofactors 18 1.64e-02 -3.27e-01 6.46e-02
Assembly of collagen fibrils and other multimeric structures 55 2.85e-05 3.26e-01 4.13e-04
A tetrasaccharide linker sequence is required for GAG synthesis 21 9.65e-03 3.26e-01 4.23e-02
Azathioprine ADME 18 1.68e-02 3.26e-01 6.58e-02
APC truncation mutants have impaired AXIN binding 14 3.53e-02 -3.25e-01 1.15e-01
AXIN missense mutants destabilize the destruction complex 14 3.53e-02 -3.25e-01 1.15e-01
Signaling by AMER1 mutants 14 3.53e-02 -3.25e-01 1.15e-01
Signaling by APC mutants 14 3.53e-02 -3.25e-01 1.15e-01
Signaling by AXIN mutants 14 3.53e-02 -3.25e-01 1.15e-01
Truncations of AMER1 destabilize the destruction complex 14 3.53e-02 -3.25e-01 1.15e-01
Adrenaline,noradrenaline inhibits insulin secretion 23 7.28e-03 3.23e-01 3.39e-02
Pentose phosphate pathway 13 4.50e-02 3.21e-01 1.35e-01
Interleukin-12 signaling 40 4.42e-04 3.21e-01 3.53e-03
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 6.57e-02 3.20e-01 1.76e-01
RHO GTPases Activate Formins 124 7.74e-10 3.20e-01 3.54e-08
Tryptophan catabolism 10 8.06e-02 3.19e-01 2.02e-01
Transferrin endocytosis and recycling 27 4.25e-03 3.18e-01 2.24e-02
RHO GTPases Activate NADPH Oxidases 21 1.18e-02 3.17e-01 4.98e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 6.87e-02 3.17e-01 1.82e-01
Defects in cobalamin (B12) metabolism 12 5.80e-02 -3.16e-01 1.62e-01
ABC transporters in lipid homeostasis 13 4.98e-02 -3.14e-01 1.45e-01
Glycogen breakdown (glycogenolysis) 14 4.23e-02 -3.14e-01 1.31e-01
Synthesis of PIPs at the Golgi membrane 15 3.57e-02 3.13e-01 1.16e-01
IRAK4 deficiency (TLR2/4) 15 3.59e-02 3.13e-01 1.17e-01
HDR through Homologous Recombination (HRR) 65 1.39e-05 3.12e-01 2.31e-04
Attenuation phase 23 9.69e-03 -3.12e-01 4.23e-02
SRP-dependent cotranslational protein targeting to membrane 111 1.44e-08 3.12e-01 4.38e-07
Polo-like kinase mediated events 14 4.39e-02 3.11e-01 1.34e-01
Processive synthesis on the lagging strand 15 3.73e-02 3.11e-01 1.20e-01
Telomere C-strand (Lagging Strand) Synthesis 34 1.77e-03 3.10e-01 1.10e-02
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 7.57e-02 -3.09e-01 1.97e-01
Interleukin-7 signaling 17 2.74e-02 -3.09e-01 9.72e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 86 7.86e-07 3.08e-01 1.74e-05
Amplification of signal from the kinetochores 86 7.86e-07 3.08e-01 1.74e-05
TNFs bind their physiological receptors 19 2.02e-02 3.08e-01 7.59e-02
p130Cas linkage to MAPK signaling for integrins 12 6.54e-02 3.07e-01 1.76e-01
MET activates PTK2 signaling 30 3.65e-03 3.07e-01 2.01e-02
Triglyceride catabolism 16 3.43e-02 -3.06e-01 1.15e-01
SARS-CoV-1 modulates host translation machinery 36 1.52e-03 3.05e-01 9.69e-03
Defects in vitamin and cofactor metabolism 20 1.81e-02 -3.05e-01 6.93e-02
MTOR signalling 41 7.20e-04 -3.05e-01 5.21e-03
CRMPs in Sema3A signaling 14 4.83e-02 3.05e-01 1.42e-01
Gap junction trafficking 30 3.97e-03 3.04e-01 2.14e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 1.17e-02 3.04e-01 4.96e-02
Interleukin-12 family signaling 46 3.71e-04 3.03e-01 3.07e-03
Crosslinking of collagen fibrils 17 3.10e-02 3.02e-01 1.06e-01
Lysosome Vesicle Biogenesis 31 3.60e-03 3.02e-01 2.00e-02
Diseases associated with the TLR signaling cascade 27 6.70e-03 3.01e-01 3.21e-02
Diseases of Immune System 27 6.70e-03 3.01e-01 3.21e-02
ROS and RNS production in phagocytes 30 4.40e-03 3.00e-01 2.31e-02
EML4 and NUDC in mitotic spindle formation 101 1.89e-07 3.00e-01 4.69e-06
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 4.44e-02 -3.00e-01 1.35e-01
Glucagon-type ligand receptors 17 3.24e-02 3.00e-01 1.10e-01
Extension of Telomeres 49 2.85e-04 3.00e-01 2.46e-03
Caspase activation via extrinsic apoptotic signalling pathway 23 1.29e-02 2.99e-01 5.35e-02
PKA activation in glucagon signalling 15 4.52e-02 -2.99e-01 1.36e-01
Biotin transport and metabolism 11 8.66e-02 -2.98e-01 2.13e-01
Diseases of glycosylation 124 9.73e-09 2.98e-01 3.16e-07
PECAM1 interactions 11 8.73e-02 2.98e-01 2.14e-01
MET promotes cell motility 40 1.13e-03 2.98e-01 7.41e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 5.44e-02 2.97e-01 1.56e-01
MHC class II antigen presentation 95 5.82e-07 2.97e-01 1.33e-05
Calnexin/calreticulin cycle 26 8.94e-03 2.96e-01 3.95e-02
Diseases of DNA repair 48 3.91e-04 2.96e-01 3.21e-03
Leishmania infection 146 6.90e-10 2.96e-01 3.25e-08
Parasitic Infection Pathways 146 6.90e-10 2.96e-01 3.25e-08
Gap junction trafficking and regulation 32 3.83e-03 2.95e-01 2.09e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 27 7.92e-03 2.95e-01 3.60e-02
Other interleukin signaling 19 2.60e-02 2.95e-01 9.35e-02
SUMOylation of immune response proteins 11 9.06e-02 2.95e-01 2.19e-01
PI-3K cascade:FGFR4 12 7.79e-02 -2.94e-01 1.98e-01
Synthesis of substrates in N-glycan biosythesis 58 1.16e-04 2.93e-01 1.29e-03
ATF6 (ATF6-alpha) activates chaperones 12 7.96e-02 2.92e-01 2.00e-01
Cytosolic sulfonation of small molecules 18 3.22e-02 2.92e-01 1.09e-01
Processive synthesis on the C-strand of the telomere 19 2.81e-02 2.91e-01 9.96e-02
Beta-catenin phosphorylation cascade 17 3.96e-02 -2.88e-01 1.25e-01
Golgi-to-ER retrograde transport 117 7.34e-08 2.88e-01 2.03e-06
Removal of the Flap Intermediate 14 6.20e-02 2.88e-01 1.71e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 3.99e-02 2.88e-01 1.25e-01
MyD88 deficiency (TLR2/4) 14 6.26e-02 2.87e-01 1.71e-01
Cell recruitment (pro-inflammatory response) 24 1.49e-02 2.87e-01 5.95e-02
Purinergic signaling in leishmaniasis infection 24 1.49e-02 2.87e-01 5.95e-02
Antimicrobial peptides 21 2.30e-02 2.87e-01 8.48e-02
Extracellular matrix organization 249 7.96e-15 2.86e-01 8.32e-13
Synthesis of glycosylphosphatidylinositol (GPI) 18 3.73e-02 2.83e-01 1.20e-01
DAP12 signaling 25 1.43e-02 2.83e-01 5.79e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 8.96e-02 2.83e-01 2.18e-01
IRE1alpha activates chaperones 50 5.43e-04 2.83e-01 4.14e-03
RHO GTPase Effectors 244 3.04e-14 2.83e-01 2.97e-12
XBP1(S) activates chaperone genes 48 7.13e-04 2.82e-01 5.18e-03
PI3K events in ERBB2 signaling 14 6.76e-02 -2.82e-01 1.81e-01
Triglyceride metabolism 24 1.72e-02 -2.81e-01 6.74e-02
Nuclear Receptor transcription pathway 42 1.64e-03 -2.81e-01 1.04e-02
Dectin-2 family 13 8.05e-02 2.80e-01 2.02e-01
The NLRP3 inflammasome 16 5.26e-02 2.80e-01 1.51e-01
Activation of ATR in response to replication stress 32 6.21e-03 2.80e-01 3.08e-02
EPH-Ephrin signaling 85 8.52e-06 2.79e-01 1.54e-04
HDR through MMEJ (alt-NHEJ) 12 9.53e-02 2.78e-01 2.27e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 8.31e-02 -2.78e-01 2.07e-01
HDR through Single Strand Annealing (SSA) 35 4.54e-03 2.77e-01 2.35e-02
Diseases associated with glycosylation precursor biosynthesis 15 6.45e-02 2.76e-01 1.74e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 16 5.72e-02 2.75e-01 1.61e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 86 1.13e-05 2.74e-01 1.94e-04
RAF activation 34 5.74e-03 -2.74e-01 2.87e-02
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.07e-02 2.74e-01 1.47e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.07e-02 2.74e-01 1.47e-01
Integrin signaling 23 2.35e-02 2.73e-01 8.59e-02
Insulin receptor recycling 25 1.87e-02 2.72e-01 7.12e-02
Assembly of the ORC complex at the origin of replication 14 7.86e-02 -2.71e-01 1.99e-01
Depolymerization of the Nuclear Lamina 15 6.95e-02 2.71e-01 1.84e-01
Degradation of the extracellular matrix 107 1.47e-06 2.70e-01 2.98e-05
Defective B3GAT3 causes JDSSDHD 16 6.24e-02 2.69e-01 1.71e-01
Chromosome Maintenance 92 9.86e-06 2.67e-01 1.76e-04
Keratan sulfate/keratin metabolism 32 9.06e-03 2.67e-01 3.99e-02
Muscle contraction 161 5.90e-09 -2.66e-01 2.05e-07
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 12 1.11e-01 2.66e-01 2.54e-01
STING mediated induction of host immune responses 15 7.61e-02 2.65e-01 1.97e-01
RHOC GTPase cycle 70 1.32e-04 2.64e-01 1.40e-03
Signaling by Retinoic Acid 35 6.84e-03 -2.64e-01 3.24e-02
Transport of bile salts and organic acids, metal ions and amine compounds 45 2.21e-03 2.64e-01 1.31e-02
CTNNB1 S33 mutants aren’t phosphorylated 15 7.77e-02 -2.63e-01 1.98e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 7.77e-02 -2.63e-01 1.98e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 7.77e-02 -2.63e-01 1.98e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 7.77e-02 -2.63e-01 1.98e-01
Signaling by CTNNB1 phospho-site mutants 15 7.77e-02 -2.63e-01 1.98e-01
Signaling by GSK3beta mutants 15 7.77e-02 -2.63e-01 1.98e-01
Regulation of FZD by ubiquitination 16 6.86e-02 -2.63e-01 1.82e-01
Physiological factors 10 1.50e-01 -2.63e-01 3.20e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 1.51e-01 -2.62e-01 3.20e-01
Neutrophil degranulation 405 1.98e-19 2.62e-01 4.83e-17
Mitotic Spindle Checkpoint 103 4.56e-06 2.62e-01 8.55e-05
Glycosphingolipid metabolism 36 7.04e-03 2.60e-01 3.29e-02
PKA activation 16 7.29e-02 -2.59e-01 1.91e-01
EPHA-mediated growth cone collapse 24 2.83e-02 2.59e-01 1.00e-01
Platelet activation, signaling and aggregation 222 8.87e-11 2.53e-01 5.89e-09
Transcriptional activation of mitochondrial biogenesis 50 2.01e-03 -2.53e-01 1.21e-02
Formation of apoptosome 11 1.48e-01 -2.52e-01 3.17e-01
Regulation of the apoptosome activity 11 1.48e-01 -2.52e-01 3.17e-01
Cell surface interactions at the vascular wall 103 1.02e-05 2.52e-01 1.78e-04
RHOB GTPase cycle 66 4.19e-04 2.51e-01 3.40e-03
Gap junction assembly 19 5.86e-02 2.51e-01 1.64e-01
Viral mRNA Translation 88 5.03e-05 2.50e-01 6.68e-04
SLBP independent Processing of Histone Pre-mRNAs 10 1.71e-01 2.50e-01 3.51e-01
Mitotic Prometaphase 187 3.80e-09 2.50e-01 1.38e-07
Activation of Matrix Metalloproteinases 20 5.33e-02 2.50e-01 1.53e-01
Synthesis of bile acids and bile salts 25 3.09e-02 -2.49e-01 1.06e-01
Regulation of Complement cascade 28 2.24e-02 2.49e-01 8.27e-02
FCERI mediated Ca+2 mobilization 29 2.02e-02 2.49e-01 7.59e-02
Peptide chain elongation 88 5.43e-05 2.49e-01 7.16e-04
Interaction between L1 and Ankyrins 25 3.12e-02 -2.49e-01 1.07e-01
HATs acetylate histones 82 9.98e-05 -2.49e-01 1.17e-03
Unfolded Protein Response (UPR) 91 4.47e-05 2.48e-01 6.11e-04
Anti-inflammatory response favouring Leishmania parasite infection 65 5.81e-04 2.47e-01 4.35e-03
Leishmania parasite growth and survival 65 5.81e-04 2.47e-01 4.35e-03
Activation of G protein gated Potassium channels 19 6.27e-02 2.47e-01 1.71e-01
G protein gated Potassium channels 19 6.27e-02 2.47e-01 1.71e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 6.27e-02 2.47e-01 1.71e-01
PI-3K cascade:FGFR3 12 1.39e-01 -2.47e-01 3.03e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 1.77e-01 2.46e-01 3.59e-01
Acyl chain remodelling of PE 20 5.71e-02 -2.46e-01 1.61e-01
Ion homeostasis 47 3.60e-03 -2.46e-01 2.00e-02
G1/S-Specific Transcription 26 3.05e-02 2.45e-01 1.05e-01
Sema3A PAK dependent Axon repulsion 16 9.14e-02 2.44e-01 2.20e-01
RHOF GTPase cycle 39 8.74e-03 2.43e-01 3.88e-02
Cell-extracellular matrix interactions 18 7.66e-02 2.41e-01 1.97e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 1.33e-01 2.40e-01 2.94e-01
Post-chaperonin tubulin folding pathway 17 8.63e-02 2.40e-01 2.13e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.50e-01 -2.40e-01 3.20e-01
Interleukin-6 signaling 10 1.90e-01 -2.39e-01 3.77e-01
Receptor Mediated Mitophagy 11 1.70e-01 -2.39e-01 3.49e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 1.36e-01 2.39e-01 2.99e-01
Defective EXT2 causes exostoses 2 13 1.36e-01 2.39e-01 2.99e-01
rRNA processing in the mitochondrion 10 1.93e-01 -2.38e-01 3.81e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 1.23e-01 2.38e-01 2.78e-01
RA biosynthesis pathway 15 1.11e-01 -2.38e-01 2.54e-01
Transport of vitamins, nucleosides, and related molecules 29 2.70e-02 2.37e-01 9.67e-02
G0 and Early G1 25 4.02e-02 2.37e-01 1.26e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 4.23e-05 2.37e-01 5.89e-04
Signaling by WNT in cancer 29 2.72e-02 -2.37e-01 9.69e-02
Defective B4GALT7 causes EDS, progeroid type 16 1.01e-01 2.37e-01 2.37e-01
Removal of the Flap Intermediate from the C-strand 17 9.11e-02 2.37e-01 2.20e-01
Asparagine N-linked glycosylation 276 1.56e-11 2.36e-01 1.14e-09
HSF1 activation 26 3.76e-02 -2.36e-01 1.20e-01
Condensation of Prophase Chromosomes 19 7.55e-02 2.36e-01 1.97e-01
Regulation of PTEN stability and activity 67 8.99e-04 -2.35e-01 6.17e-03
Negative regulation of FLT3 13 1.44e-01 2.34e-01 3.12e-01
Meiotic recombination 26 3.90e-02 2.34e-01 1.24e-01
Response to elevated platelet cytosolic Ca2+ 113 1.80e-05 2.34e-01 2.72e-04
Degradation of beta-catenin by the destruction complex 83 2.40e-04 -2.33e-01 2.18e-03
RHO GTPases activate CIT 19 7.87e-02 2.33e-01 1.99e-01
RUNX2 regulates osteoblast differentiation 21 6.48e-02 2.33e-01 1.74e-01
Factors involved in megakaryocyte development and platelet production 114 1.79e-05 2.33e-01 2.72e-04
Activation of SMO 16 1.08e-01 2.32e-01 2.49e-01
FOXO-mediated transcription 58 2.24e-03 -2.32e-01 1.32e-02
Selective autophagy 71 7.50e-04 -2.31e-01 5.35e-03
Integrin cell surface interactions 76 5.11e-04 2.31e-01 3.93e-03
Intra-Golgi and retrograde Golgi-to-ER traffic 183 7.72e-08 2.31e-01 2.09e-06
Other semaphorin interactions 19 8.21e-02 2.30e-01 2.05e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.11e-01 -2.30e-01 2.54e-01
Telomere Extension By Telomerase 21 6.78e-02 2.30e-01 1.81e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 1.87e-01 2.30e-01 3.73e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 94 1.18e-04 2.30e-01 1.29e-03
RAC1 GTPase cycle 174 1.76e-07 2.30e-01 4.43e-06
Chemokine receptors bind chemokines 30 2.95e-02 2.30e-01 1.02e-01
RHOA GTPase cycle 143 2.20e-06 2.29e-01 4.29e-05
Eukaryotic Translation Termination 92 1.45e-04 2.29e-01 1.51e-03
Cellular response to hypoxia 72 7.78e-04 -2.29e-01 5.44e-03
Cilium Assembly 185 7.96e-08 2.29e-01 2.12e-06
IRAK2 mediated activation of TAK1 complex 10 2.11e-01 -2.29e-01 4.04e-01
trans-Golgi Network Vesicle Budding 68 1.18e-03 2.28e-01 7.62e-03
RAC3 GTPase cycle 87 2.48e-04 2.27e-01 2.24e-03
Sensory processing of sound by inner hair cells of the cochlea 47 7.04e-03 2.27e-01 3.29e-02
Inactivation of CSF3 (G-CSF) signaling 23 5.97e-02 -2.27e-01 1.66e-01
Regulation of RUNX1 Expression and Activity 18 9.78e-02 2.25e-01 2.32e-01
Homology Directed Repair 100 1.05e-04 2.25e-01 1.21e-03
ECM proteoglycans 65 1.81e-03 2.24e-01 1.12e-02
Inflammasomes 20 8.37e-02 2.23e-01 2.08e-01
SUMOylation of intracellular receptors 27 4.58e-02 -2.22e-01 1.37e-01
Cohesin Loading onto Chromatin 10 2.24e-01 2.22e-01 4.19e-01
Degradation of DVL 55 4.43e-03 -2.22e-01 2.32e-02
ERBB2 Activates PTK6 Signaling 11 2.05e-01 -2.21e-01 3.98e-01
Interleukin-4 and Interleukin-13 signaling 84 4.82e-04 2.20e-01 3.75e-03
Cardiac conduction 97 1.77e-04 -2.20e-01 1.74e-03
Platelet Aggregation (Plug Formation) 31 3.44e-02 2.20e-01 1.15e-01
Neddylation 234 7.82e-09 -2.19e-01 2.60e-07
Selenocysteine synthesis 92 2.80e-04 2.19e-01 2.46e-03
Semaphorin interactions 62 2.89e-03 2.19e-01 1.65e-02
Eukaryotic Translation Elongation 93 2.72e-04 2.19e-01 2.44e-03
Deactivation of the beta-catenin transactivating complex 39 1.83e-02 -2.18e-01 7.01e-02
VEGFA-VEGFR2 Pathway 95 2.40e-04 2.18e-01 2.18e-03
SARS-CoV-2 modulates host translation machinery 49 8.36e-03 2.18e-01 3.75e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.84e-04 2.17e-01 2.46e-03
SARS-CoV-1-host interactions 94 2.86e-04 2.17e-01 2.46e-03
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 6.62e-03 -2.16e-01 3.21e-02
SHC1 events in EGFR signaling 10 2.39e-01 2.15e-01 4.36e-01
Platelet degranulation 109 1.07e-04 2.15e-01 1.23e-03
RAC2 GTPase cycle 85 6.35e-04 2.14e-01 4.69e-03
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.92e-02 -2.14e-01 1.24e-01
Regulation of Apoptosis 51 8.21e-03 -2.14e-01 3.69e-02
Golgi Associated Vesicle Biogenesis 54 6.55e-03 2.14e-01 3.20e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 3.16e-03 -2.13e-01 1.78e-02
CDC42 GTPase cycle 147 8.34e-06 2.13e-01 1.52e-04
Amyloid fiber formation 41 1.84e-02 2.13e-01 7.02e-02
Role of phospholipids in phagocytosis 22 8.43e-02 2.13e-01 2.09e-01
Mismatch Repair 14 1.68e-01 2.13e-01 3.48e-01
Sphingolipid metabolism 73 1.73e-03 2.12e-01 1.08e-02
Activation of gene expression by SREBF (SREBP) 42 1.75e-02 -2.12e-01 6.81e-02
Macroautophagy 124 4.80e-05 -2.12e-01 6.43e-04
Activation of the AP-1 family of transcription factors 10 2.48e-01 -2.11e-01 4.47e-01
Cargo concentration in the ER 28 5.35e-02 2.11e-01 1.53e-01
Hemostasis 479 3.53e-15 2.11e-01 3.97e-13
COPI-mediated anterograde transport 90 5.71e-04 2.10e-01 4.32e-03
Anchoring of the basal body to the plasma membrane 95 4.04e-04 2.10e-01 3.30e-03
GPER1 signaling 37 2.73e-02 2.10e-01 9.72e-02
Negative regulation of MAPK pathway 41 2.03e-02 -2.10e-01 7.59e-02
Activation of the pre-replicative complex 30 4.72e-02 2.09e-01 1.40e-01
Degradation of AXIN 53 8.56e-03 -2.09e-01 3.81e-02
Formation of the cornified envelope 24 7.68e-02 2.09e-01 1.97e-01
Keratinization 24 7.68e-02 2.09e-01 1.97e-01
NGF-stimulated transcription 35 3.27e-02 2.09e-01 1.11e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 6.11e-02 -2.08e-01 1.69e-01
Translation of Structural Proteins 9694635 57 6.66e-03 2.08e-01 3.21e-02
Interleukin-35 Signalling 10 2.56e-01 -2.08e-01 4.55e-01
Reproduction 65 3.93e-03 2.07e-01 2.13e-02
RHO GTPases activate KTN1 10 2.58e-01 2.07e-01 4.56e-01
G alpha (12/13) signalling events 69 3.05e-03 2.06e-01 1.73e-02
Protein methylation 15 1.68e-01 -2.06e-01 3.48e-01
G2/M DNA damage checkpoint 57 7.57e-03 2.05e-01 3.48e-02
TICAM1-dependent activation of IRF3/IRF7 12 2.21e-01 2.04e-01 4.16e-01
Basigin interactions 22 9.99e-02 2.03e-01 2.35e-01
Fatty acid metabolism 144 2.76e-05 -2.03e-01 4.03e-04
Bile acid and bile salt metabolism 28 6.40e-02 -2.02e-01 1.73e-01
p38MAPK events 13 2.07e-01 2.02e-01 4.00e-01
Expression and translocation of olfactory receptors 26 7.45e-02 -2.02e-01 1.94e-01
Degradation of GLI2 by the proteasome 57 8.56e-03 -2.01e-01 3.81e-02
TP53 Regulates Metabolic Genes 82 1.77e-03 -2.00e-01 1.10e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 1.21e-02 -1.99e-01 5.04e-02
G alpha (q) signalling events 125 1.22e-04 1.99e-01 1.32e-03
Vpu mediated degradation of CD4 50 1.49e-02 -1.99e-01 5.95e-02
ABC-family proteins mediated transport 92 9.94e-04 -1.99e-01 6.72e-03
p75 NTR receptor-mediated signalling 91 1.09e-03 1.98e-01 7.22e-03
PI3K Cascade 32 5.25e-02 -1.98e-01 1.51e-01
MAP kinase activation 63 6.58e-03 -1.98e-01 3.21e-02
Lewis blood group biosynthesis 10 2.81e-01 1.97e-01 4.84e-01
Collagen chain trimerization 39 3.35e-02 1.97e-01 1.12e-01
Autophagy 139 6.32e-05 -1.97e-01 8.18e-04
ERK/MAPK targets 22 1.11e-01 -1.96e-01 2.54e-01
Apoptotic cleavage of cellular proteins 35 4.45e-02 1.96e-01 1.35e-01
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 1.44e-02 -1.96e-01 5.80e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 8.99e-02 1.96e-01 2.18e-01
Iron uptake and transport 53 1.40e-02 1.95e-01 5.69e-02
Non-integrin membrane-ECM interactions 57 1.09e-02 1.95e-01 4.67e-02
mTORC1-mediated signalling 24 9.80e-02 -1.95e-01 2.32e-01
IRF3-mediated induction of type I IFN 12 2.43e-01 1.95e-01 4.41e-01
Regulation of ornithine decarboxylase (ODC) 48 1.98e-02 -1.95e-01 7.44e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.44e-01 1.94e-01 4.44e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 2.12e-02 -1.92e-01 7.88e-02
Innate Immune System 838 5.19e-21 1.92e-01 1.90e-18
Listeria monocytogenes entry into host cells 17 1.70e-01 1.92e-01 3.50e-01
Signaling by MET 75 4.08e-03 1.92e-01 2.18e-02
Sensory processing of sound 51 1.78e-02 1.92e-01 6.89e-02
Unblocking of NMDA receptors, glutamate binding and activation 17 1.74e-01 -1.90e-01 3.56e-01
Telomere Maintenance 69 6.35e-03 1.90e-01 3.12e-02
FOXO-mediated transcription of cell cycle genes 16 1.88e-01 -1.90e-01 3.75e-01
SARS-CoV-1 activates/modulates innate immune responses 39 4.01e-02 1.90e-01 1.25e-01
Late SARS-CoV-2 Infection Events 66 7.80e-03 1.89e-01 3.55e-02
Metalloprotease DUBs 19 1.53e-01 -1.89e-01 3.24e-01
Plasma lipoprotein clearance 32 6.41e-02 1.89e-01 1.73e-01
Antigen processing: Ubiquitination & Proteasome degradation 292 2.97e-08 -1.89e-01 8.69e-07
NIK–>noncanonical NF-kB signaling 57 1.38e-02 -1.89e-01 5.65e-02
FCERI mediated NF-kB activation 78 4.10e-03 -1.88e-01 2.18e-02
TCF dependent signaling in response to WNT 160 4.42e-05 -1.87e-01 6.10e-04
PI-3K cascade:FGFR2 14 2.26e-01 -1.87e-01 4.21e-01
Regulation of KIT signaling 14 2.26e-01 1.87e-01 4.21e-01
Biosynthesis of specialized proresolving mediators (SPMs) 15 2.11e-01 1.87e-01 4.04e-01
GLI3 is processed to GLI3R by the proteasome 57 1.50e-02 -1.86e-01 5.96e-02
tRNA Aminoacylation 42 3.71e-02 -1.86e-01 1.20e-01
Formation of WDR5-containing histone-modifying complexes 42 3.74e-02 -1.86e-01 1.20e-01
Vif-mediated degradation of APOBEC3G 52 2.09e-02 -1.85e-01 7.81e-02
Nuclear events stimulated by ALK signaling in cancer 18 1.74e-01 1.85e-01 3.56e-01
Insulin processing 20 1.53e-01 1.85e-01 3.24e-01
O-glycosylation of TSR domain-containing proteins 35 5.91e-02 1.84e-01 1.65e-01
Repression of WNT target genes 14 2.33e-01 -1.84e-01 4.27e-01
Interleukin-15 signaling 13 2.52e-01 -1.84e-01 4.51e-01
ER to Golgi Anterograde Transport 139 1.96e-04 1.83e-01 1.86e-03
Downstream TCR signaling 80 4.84e-03 -1.82e-01 2.49e-02
Interleukin-17 signaling 67 1.03e-02 -1.81e-01 4.47e-02
Role of LAT2/NTAL/LAB on calcium mobilization 16 2.10e-01 1.81e-01 4.04e-01
Asymmetric localization of PCP proteins 61 1.47e-02 -1.81e-01 5.92e-02
Sensory processing of sound by outer hair cells of the cochlea 37 5.80e-02 1.80e-01 1.62e-01
RHOBTB1 GTPase cycle 23 1.35e-01 -1.80e-01 2.98e-01
Dectin-1 mediated noncanonical NF-kB signaling 58 1.78e-02 -1.80e-01 6.89e-02
Signaling by NTRK3 (TRKC) 16 2.14e-01 1.80e-01 4.08e-01
Synthesis of PC 22 1.46e-01 -1.79e-01 3.13e-01
SUMOylation of DNA replication proteins 45 3.84e-02 1.78e-01 1.22e-01
Signaling by ERBB2 KD Mutants 23 1.39e-01 -1.78e-01 3.02e-01
Processing of DNA double-strand break ends 60 1.75e-02 1.77e-01 6.81e-02
Olfactory Signaling Pathway 30 9.31e-02 -1.77e-01 2.23e-01
Transport to the Golgi and subsequent modification 164 9.36e-05 1.77e-01 1.13e-03
Meiosis 50 3.10e-02 1.76e-01 1.06e-01
RORA activates gene expression 18 1.96e-01 -1.76e-01 3.85e-01
ABC transporter disorders 69 1.15e-02 -1.76e-01 4.92e-02
Nitric oxide stimulates guanylate cyclase 18 1.97e-01 -1.76e-01 3.85e-01
PCNA-Dependent Long Patch Base Excision Repair 21 1.64e-01 1.76e-01 3.43e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 2.93e-01 1.75e-01 4.99e-01
Myogenesis 25 1.31e-01 -1.75e-01 2.90e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.67e-01 1.74e-01 3.47e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.67e-01 1.74e-01 3.47e-01
GABA receptor activation 39 6.11e-02 1.73e-01 1.69e-01
Keratan sulfate biosynthesis 26 1.27e-01 1.73e-01 2.84e-01
Signaling by ERBB2 ECD mutants 16 2.32e-01 -1.73e-01 4.27e-01
Signaling by VEGF 104 2.37e-03 1.73e-01 1.39e-02
MET activates RAP1 and RAC1 11 3.23e-01 1.72e-01 5.30e-01
Diseases of mitotic cell cycle 38 6.65e-02 1.72e-01 1.78e-01
Signaling by Rho GTPases 596 9.30e-13 1.72e-01 8.00e-11
Complement cascade 32 9.31e-02 1.72e-01 2.23e-01
G alpha (z) signalling events 37 7.12e-02 1.71e-01 1.88e-01
COPII-mediated vesicle transport 63 1.89e-02 1.71e-01 7.15e-02
SCF-beta-TrCP mediated degradation of Emi1 53 3.17e-02 -1.71e-01 1.08e-01
Cytoprotection by HMOX1 58 2.50e-02 -1.70e-01 9.08e-02
Defective B3GALTL causes PpS 34 8.76e-02 1.69e-01 2.15e-01
Miscellaneous transport and binding events 21 1.79e-01 1.69e-01 3.61e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 30 1.09e-01 1.69e-01 2.51e-01
PKA-mediated phosphorylation of CREB 18 2.14e-01 -1.69e-01 4.08e-01
InlB-mediated entry of Listeria monocytogenes into host cell 13 2.91e-01 1.69e-01 4.98e-01
Influenza Viral RNA Transcription and Replication 135 7.24e-04 1.69e-01 5.22e-03
Ubiquitin-dependent degradation of Cyclin D 50 3.92e-02 -1.69e-01 1.24e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 9.84e-05 1.68e-01 1.17e-03
Selenoamino acid metabolism 114 1.90e-03 1.68e-01 1.17e-02
Signaling by NODAL 14 2.77e-01 -1.68e-01 4.78e-01
Fanconi Anemia Pathway 35 8.56e-02 1.68e-01 2.11e-01
Degradation of GLI1 by the proteasome 57 2.87e-02 -1.68e-01 1.01e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.14e-01 -1.67e-01 2.59e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 611 2.42e-12 1.67e-01 1.96e-10
Transcriptional Regulation by E2F6 34 9.31e-02 1.66e-01 2.23e-01
Cellular response to heat stress 97 4.70e-03 -1.66e-01 2.43e-02
ER Quality Control Compartment (ERQC) 21 1.88e-01 1.66e-01 3.75e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 4.48e-02 -1.66e-01 1.35e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 2.37e-01 1.66e-01 4.34e-01
Sphingolipid de novo biosynthesis 37 8.22e-02 1.65e-01 2.05e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 3.43e-01 -1.65e-01 5.48e-01
alpha-linolenic acid (ALA) metabolism 11 3.43e-01 -1.65e-01 5.48e-01
Formation of a pool of free 40S subunits 100 4.39e-03 1.65e-01 2.31e-02
Intra-Golgi traffic 41 6.80e-02 1.65e-01 1.81e-01
Stabilization of p53 54 3.73e-02 -1.64e-01 1.20e-01
rRNA processing in the nucleus and cytosol 190 1.00e-04 1.64e-01 1.17e-03
E3 ubiquitin ligases ubiquitinate target proteins 43 6.35e-02 -1.64e-01 1.73e-01
Regulation of RUNX2 expression and activity 70 1.81e-02 -1.63e-01 6.93e-02
Metabolism of porphyrins 20 2.06e-01 -1.63e-01 3.99e-01
Cell Cycle Checkpoints 239 1.43e-05 1.63e-01 2.35e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 4.83e-02 -1.63e-01 1.42e-01
p53-Independent DNA Damage Response 49 4.83e-02 -1.63e-01 1.42e-01
p53-Independent G1/S DNA damage checkpoint 49 4.83e-02 -1.63e-01 1.42e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.50e-01 -1.63e-01 3.20e-01
Cellular response to starvation 149 6.04e-04 1.63e-01 4.49e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.52e-01 -1.62e-01 5.59e-01
Telomere C-strand synthesis initiation 13 3.12e-01 1.62e-01 5.16e-01
Diseases of metabolism 204 6.83e-05 1.62e-01 8.68e-04
Membrane binding and targetting of GAG proteins 14 2.95e-01 -1.62e-01 5.00e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 2.95e-01 -1.62e-01 5.00e-01
Influenza Infection 154 5.39e-04 1.62e-01 4.13e-03
ZBP1(DAI) mediated induction of type I IFNs 20 2.17e-01 1.60e-01 4.12e-01
Uptake and function of anthrax toxins 11 3.60e-01 -1.59e-01 5.67e-01
Separation of Sister Chromatids 173 3.13e-04 1.59e-01 2.64e-03
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 9.89e-02 1.59e-01 2.34e-01
Translesion synthesis by POLI 17 2.57e-01 1.59e-01 4.56e-01
Phosphorylation of the APC/C 20 2.20e-01 1.59e-01 4.15e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 6.02e-02 -1.58e-01 1.67e-01
DNA Double-Strand Break Repair 130 1.85e-03 1.58e-01 1.14e-02
Intrinsic Pathway of Fibrin Clot Formation 12 3.43e-01 -1.58e-01 5.48e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 3.24e-01 1.58e-01 5.31e-01
Negative regulation of NOTCH4 signaling 54 4.50e-02 -1.58e-01 1.35e-01
Peptide hormone metabolism 54 4.59e-02 1.57e-01 1.37e-01
AURKA Activation by TPX2 71 2.21e-02 1.57e-01 8.20e-02
IRS-related events triggered by IGF1R 39 8.99e-02 -1.57e-01 2.18e-01
Extra-nuclear estrogen signaling 64 3.01e-02 1.57e-01 1.04e-01
Negative regulation of MET activity 19 2.38e-01 1.56e-01 4.36e-01
ADORA2B mediated anti-inflammatory cytokines production 34 1.15e-01 1.56e-01 2.61e-01
PPARA activates gene expression 106 5.56e-03 -1.56e-01 2.81e-02
MAP2K and MAPK activation 36 1.06e-01 1.56e-01 2.46e-01
Recruitment of NuMA to mitotic centrosomes 87 1.22e-02 1.56e-01 5.08e-02
RAB geranylgeranylation 55 4.63e-02 1.55e-01 1.38e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 4.25e-02 1.55e-01 1.32e-01
Regulation of BACH1 activity 11 3.73e-01 -1.55e-01 5.78e-01
ERBB2 Regulates Cell Motility 13 3.33e-01 -1.55e-01 5.40e-01
Ub-specific processing proteases 155 8.68e-04 -1.55e-01 5.99e-03
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.57e-01 -1.55e-01 3.30e-01
N-Glycan antennae elongation 13 3.35e-01 1.55e-01 5.40e-01
RIPK1-mediated regulated necrosis 30 1.43e-01 1.54e-01 3.10e-01
Regulation of necroptotic cell death 30 1.43e-01 1.54e-01 3.10e-01
PI-3K cascade:FGFR1 13 3.35e-01 -1.54e-01 5.40e-01
Cargo trafficking to the periciliary membrane 45 7.32e-02 1.54e-01 1.91e-01
RIP-mediated NFkB activation via ZBP1 17 2.74e-01 1.53e-01 4.75e-01
Transcriptional Regulation by VENTX 38 1.03e-01 1.53e-01 2.39e-01
TP53 Regulates Transcription of Cell Death Genes 41 9.02e-02 1.53e-01 2.19e-01
Metabolism of nucleotides 84 1.55e-02 1.53e-01 6.14e-02
Downstream signaling of activated FGFR4 19 2.49e-01 -1.53e-01 4.48e-01
RNA Polymerase III Abortive And Retractive Initiation 41 9.12e-02 -1.53e-01 2.20e-01
RNA Polymerase III Transcription 41 9.12e-02 -1.53e-01 2.20e-01
Activation of BAD and translocation to mitochondria 15 3.07e-01 1.52e-01 5.11e-01
Plasma lipoprotein remodeling 19 2.51e-01 1.52e-01 4.50e-01
Late endosomal microautophagy 31 1.43e-01 -1.52e-01 3.10e-01
Phase I - Functionalization of compounds 69 2.91e-02 -1.52e-01 1.02e-01
NPAS4 regulates expression of target genes 19 2.53e-01 -1.52e-01 4.52e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 4.07e-01 1.51e-01 6.09e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 70 2.87e-02 -1.51e-01 1.01e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 2.67e-01 1.51e-01 4.64e-01
Regulation of lipid metabolism by PPARalpha 108 6.67e-03 -1.51e-01 3.21e-02
Early Phase of HIV Life Cycle 14 3.28e-01 1.51e-01 5.35e-01
FCERI mediated MAPK activation 31 1.46e-01 1.51e-01 3.13e-01
Formation of TC-NER Pre-Incision Complex 53 5.79e-02 -1.51e-01 1.62e-01
Cross-presentation of soluble exogenous antigens (endosomes) 46 7.85e-02 -1.50e-01 1.99e-01
HS-GAG biosynthesis 22 2.24e-01 1.50e-01 4.19e-01
FCGR3A-mediated IL10 synthesis 35 1.26e-01 1.50e-01 2.83e-01
Circadian Clock 66 3.65e-02 -1.49e-01 1.18e-01
Transcription of E2F targets under negative control by DREAM complex 18 2.75e-01 1.49e-01 4.76e-01
Signaling by Activin 14 3.37e-01 -1.48e-01 5.41e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 7.62e-02 -1.48e-01 1.97e-01
Cell Cycle 591 9.30e-10 1.48e-01 3.89e-08
Regulation of insulin secretion 60 4.78e-02 1.48e-01 1.42e-01
SARS-CoV-1 Infection 136 2.98e-03 1.48e-01 1.70e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 6.74e-03 1.47e-01 3.21e-02
Nonsense-Mediated Decay (NMD) 114 6.74e-03 1.47e-01 3.21e-02
Plasma lipoprotein assembly, remodeling, and clearance 55 5.99e-02 1.47e-01 1.66e-01
Synthesis of PIPs at the late endosome membrane 11 4.01e-01 1.46e-01 6.06e-01
SHC-mediated cascade:FGFR1 13 3.62e-01 1.46e-01 5.69e-01
Translesion synthesis by REV1 16 3.13e-01 1.46e-01 5.16e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 3.13e-01 1.46e-01 5.16e-01
Alpha-protein kinase 1 signaling pathway 11 4.04e-01 -1.45e-01 6.07e-01
RNA Polymerase III Transcription Termination 23 2.28e-01 -1.45e-01 4.23e-01
IGF1R signaling cascade 40 1.13e-01 -1.45e-01 2.57e-01
IRS-mediated signalling 36 1.33e-01 -1.45e-01 2.93e-01
L1CAM interactions 100 1.25e-02 1.45e-01 5.18e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 41 1.09e-01 -1.45e-01 2.51e-01
Translesion synthesis by POLK 17 3.02e-01 1.44e-01 5.06e-01
Infection with Mycobacterium tuberculosis 27 1.94e-01 1.44e-01 3.83e-01
RHO GTPase cycle 417 4.81e-07 1.44e-01 1.12e-05
rRNA processing 200 4.66e-04 1.44e-01 3.65e-03
O-linked glycosylation of mucins 40 1.16e-01 1.44e-01 2.63e-01
Assembly of active LPL and LIPC lipase complexes 12 3.89e-01 1.44e-01 5.91e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 3.37e-01 -1.43e-01 5.41e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 3.37e-01 -1.43e-01 5.41e-01
Class A/1 (Rhodopsin-like receptors) 138 3.76e-03 1.43e-01 2.06e-02
Nuclear Envelope Breakdown 53 7.27e-02 1.43e-01 1.91e-01
APC-Cdc20 mediated degradation of Nek2A 26 2.08e-01 1.43e-01 4.02e-01
SLC transporter disorders 67 4.38e-02 1.42e-01 1.34e-01
Mitotic Metaphase and Anaphase 217 3.11e-04 1.42e-01 2.64e-03
Arachidonic acid metabolism 38 1.29e-01 1.42e-01 2.89e-01
Cell Cycle, Mitotic 481 1.04e-07 1.42e-01 2.71e-06
Signalling to RAS 19 2.84e-01 1.42e-01 4.88e-01
Loss of Nlp from mitotic centrosomes 68 4.33e-02 1.42e-01 1.33e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 4.33e-02 1.42e-01 1.33e-01
Recognition of DNA damage by PCNA-containing replication complex 30 1.79e-01 1.42e-01 3.61e-01
Adherens junctions interactions 47 9.41e-02 1.41e-01 2.25e-01
Synthesis of PIPs at the early endosome membrane 16 3.29e-01 1.41e-01 5.36e-01
Immune System 1596 1.92e-20 1.41e-01 5.60e-18
RAB GEFs exchange GTP for GDP on RABs 85 2.50e-02 1.41e-01 9.08e-02
Signaling by high-kinase activity BRAF mutants 32 1.68e-01 1.41e-01 3.48e-01
Cell death signalling via NRAGE, NRIF and NADE 73 3.78e-02 1.41e-01 1.21e-01
Regulation of TP53 Activity through Association with Co-factors 11 4.20e-01 1.40e-01 6.17e-01
KEAP1-NFE2L2 pathway 101 1.49e-02 -1.40e-01 5.95e-02
Nuclear Pore Complex (NPC) Disassembly 36 1.46e-01 1.40e-01 3.14e-01
Metabolism of carbohydrates 254 1.36e-04 1.39e-01 1.42e-03
Response of Mtb to phagocytosis 23 2.48e-01 1.39e-01 4.47e-01
SLC-mediated transmembrane transport 158 2.57e-03 1.39e-01 1.50e-02
DNA Damage Recognition in GG-NER 38 1.38e-01 -1.39e-01 3.02e-01
Transcriptional regulation of pluripotent stem cells 17 3.22e-01 -1.39e-01 5.29e-01
Peptide ligand-binding receptors 73 4.05e-02 1.39e-01 1.26e-01
Mitotic Anaphase 216 4.54e-04 1.39e-01 3.58e-03
Insulin receptor signalling cascade 41 1.25e-01 -1.38e-01 2.81e-01
Pre-NOTCH Processing in Golgi 18 3.10e-01 1.38e-01 5.13e-01
Nucleotide biosynthesis 12 4.08e-01 1.38e-01 6.09e-01
HDACs deacetylate histones 36 1.53e-01 1.38e-01 3.24e-01
UCH proteinases 85 2.87e-02 -1.37e-01 1.01e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 3.01e-01 -1.37e-01 5.05e-01
L13a-mediated translational silencing of Ceruloplasmin expression 110 1.32e-02 1.37e-01 5.42e-02
Purine catabolism 14 3.75e-01 1.37e-01 5.80e-01
activated TAK1 mediates p38 MAPK activation 23 2.57e-01 -1.37e-01 4.56e-01
Long-term potentiation 19 3.04e-01 -1.36e-01 5.06e-01
Diseases of programmed cell death 47 1.06e-01 1.36e-01 2.46e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.23e-01 -1.36e-01 4.18e-01
Signaling by PDGF 54 8.50e-02 1.36e-01 2.10e-01
Activation of GABAB receptors 31 1.92e-01 1.35e-01 3.81e-01
GABA B receptor activation 31 1.92e-01 1.35e-01 3.81e-01
Sema4D in semaphorin signaling 24 2.51e-01 1.35e-01 4.51e-01
Interactions of Rev with host cellular proteins 37 1.55e-01 1.35e-01 3.27e-01
Signaling by ERBB2 in Cancer 24 2.52e-01 -1.35e-01 4.51e-01
Rev-mediated nuclear export of HIV RNA 35 1.67e-01 1.35e-01 3.48e-01
Rap1 signalling 13 4.00e-01 1.35e-01 6.04e-01
Signaling by CSF3 (G-CSF) 28 2.18e-01 -1.34e-01 4.14e-01
Receptor-type tyrosine-protein phosphatases 13 4.03e-01 1.34e-01 6.07e-01
Aflatoxin activation and detoxification 12 4.23e-01 -1.34e-01 6.19e-01
Vesicle-mediated transport 596 2.97e-08 1.33e-01 8.69e-07
Effects of PIP2 hydrolysis 23 2.70e-01 1.33e-01 4.69e-01
Regulated Necrosis 52 9.79e-02 1.33e-01 2.32e-01
Defective CFTR causes cystic fibrosis 57 8.33e-02 -1.33e-01 2.07e-01
Transport of the SLBP Dependant Mature mRNA 36 1.69e-01 1.33e-01 3.48e-01
NRAGE signals death through JNK 56 8.64e-02 1.33e-01 2.13e-01
CLEC7A (Dectin-1) induces NFAT activation 11 4.47e-01 1.32e-01 6.42e-01
Chaperonin-mediated protein folding 76 4.63e-02 1.32e-01 1.38e-01
Regulation of TLR by endogenous ligand 15 3.76e-01 1.32e-01 5.80e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 11 4.50e-01 -1.32e-01 6.44e-01
BBSome-mediated cargo-targeting to cilium 21 2.99e-01 1.31e-01 5.03e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 4.74e-01 1.31e-01 6.64e-01
RND3 GTPase cycle 36 1.77e-01 1.30e-01 3.58e-01
Glutathione conjugation 27 2.42e-01 -1.30e-01 4.40e-01
Centrosome maturation 80 4.44e-02 1.30e-01 1.35e-01
Recruitment of mitotic centrosome proteins and complexes 80 4.44e-02 1.30e-01 1.35e-01
GPCR ligand binding 191 2.02e-03 1.30e-01 1.21e-02
Nuclear events mediated by NFE2L2 76 5.17e-02 -1.29e-01 1.49e-01
Protein ubiquitination 63 7.67e-02 -1.29e-01 1.97e-01
NRIF signals cell death from the nucleus 16 3.72e-01 1.29e-01 5.78e-01
Interleukin-20 family signaling 14 4.06e-01 -1.28e-01 6.08e-01
Regulation of TP53 Activity through Methylation 19 3.33e-01 -1.28e-01 5.40e-01
Hh mutants are degraded by ERAD 53 1.08e-01 -1.28e-01 2.49e-01
Interferon alpha/beta signaling 56 9.92e-02 1.27e-01 2.34e-01
AKT phosphorylates targets in the cytosol 14 4.09e-01 -1.27e-01 6.09e-01
Metabolism of polyamines 56 9.94e-02 -1.27e-01 2.35e-01
SARS-CoV Infections 372 2.74e-05 1.27e-01 4.03e-04
RNA Polymerase III Transcription Initiation 36 1.89e-01 -1.27e-01 3.75e-01
Deubiquitination 226 1.07e-03 -1.27e-01 7.12e-03
Protein folding 82 4.81e-02 1.26e-01 1.42e-01
Postmitotic nuclear pore complex (NPC) reformation 27 2.57e-01 1.26e-01 4.56e-01
Activation of NF-kappaB in B cells 65 7.95e-02 -1.26e-01 2.00e-01
PI Metabolism 78 5.56e-02 1.25e-01 1.58e-01
Termination of O-glycan biosynthesis 13 4.34e-01 -1.25e-01 6.30e-01
Growth hormone receptor signaling 18 3.59e-01 -1.25e-01 5.66e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 111 2.35e-02 1.25e-01 8.59e-02
Signaling by ERBB2 TMD/JMD mutants 20 3.35e-01 -1.25e-01 5.40e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 43 1.58e-01 -1.24e-01 3.33e-01
Termination of translesion DNA synthesis 31 2.31e-01 1.24e-01 4.26e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 23 3.03e-01 1.24e-01 5.06e-01
Somitogenesis 50 1.31e-01 -1.24e-01 2.90e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 7.03e-02 1.23e-01 1.86e-01
M Phase 343 9.10e-05 1.23e-01 1.12e-03
Smooth Muscle Contraction 36 2.01e-01 -1.23e-01 3.91e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 8.85e-02 -1.23e-01 2.16e-01
Synaptic adhesion-like molecules 18 3.66e-01 1.23e-01 5.74e-01
Infectious disease 821 2.60e-09 1.23e-01 9.76e-08
Constitutive Signaling by Overexpressed ERBB2 11 4.80e-01 1.23e-01 6.69e-01
Downstream signaling of activated FGFR3 19 3.54e-01 -1.23e-01 5.60e-01
Synthesis of IP2, IP, and Ins in the cytosol 12 4.61e-01 -1.23e-01 6.53e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 32 2.30e-01 1.23e-01 4.26e-01
RHOBTB GTPase Cycle 35 2.11e-01 -1.22e-01 4.05e-01
GPCR downstream signalling 357 7.88e-05 1.22e-01 9.85e-04
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 5.05e-01 -1.22e-01 6.90e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 4.85e-01 1.22e-01 6.75e-01
Acyl chain remodelling of PG 11 4.86e-01 1.21e-01 6.75e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.20e-01 -1.21e-01 2.72e-01
Membrane Trafficking 567 9.52e-07 1.21e-01 2.05e-05
Signaling by GPCR 396 4.03e-05 1.21e-01 5.67e-04
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 4.70e-01 1.21e-01 6.62e-01
Nucleotide catabolism 26 2.90e-01 1.20e-01 4.96e-01
Cellular response to chemical stress 183 5.17e-03 -1.20e-01 2.64e-02
PTEN Regulation 138 1.50e-02 -1.20e-01 5.96e-02
SARS-CoV-2 Infection 264 8.21e-04 1.20e-01 5.69e-03
Regulation of localization of FOXO transcription factors 12 4.73e-01 1.20e-01 6.64e-01
G alpha (i) signalling events 173 6.95e-03 1.19e-01 3.28e-02
Transport of Mature Transcript to Cytoplasm 81 6.44e-02 1.19e-01 1.74e-01
Apoptotic execution phase 43 1.78e-01 1.19e-01 3.59e-01
Downregulation of TGF-beta receptor signaling 26 2.95e-01 -1.19e-01 5.00e-01
RHOU GTPase cycle 39 2.00e-01 1.19e-01 3.90e-01
Cap-dependent Translation Initiation 118 2.63e-02 1.18e-01 9.43e-02
Eukaryotic Translation Initiation 118 2.63e-02 1.18e-01 9.43e-02
Cell-Cell communication 120 2.51e-02 1.18e-01 9.09e-02
Regulation of innate immune responses to cytosolic DNA 14 4.43e-01 1.18e-01 6.38e-01
Signaling by CSF1 (M-CSF) in myeloid cells 30 2.62e-01 1.18e-01 4.62e-01
Synthesis, secretion, and deacylation of Ghrelin 11 4.97e-01 1.18e-01 6.84e-01
NCAM signaling for neurite out-growth 51 1.44e-01 1.18e-01 3.12e-01
Hh mutants abrogate ligand secretion 55 1.30e-01 -1.18e-01 2.90e-01
Metabolism of amino acids and derivatives 317 3.17e-04 -1.18e-01 2.66e-03
Eicosanoid ligand-binding receptors 13 4.63e-01 1.18e-01 6.54e-01
Interferon gamma signaling 73 8.27e-02 1.18e-01 2.06e-01
Synthesis of PA 30 2.66e-01 -1.17e-01 4.64e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 4.32e-01 1.17e-01 6.27e-01
CD28 co-stimulation 30 2.68e-01 1.17e-01 4.66e-01
Metabolism of water-soluble vitamins and cofactors 110 3.44e-02 -1.17e-01 1.15e-01
Negative regulation of FGFR4 signaling 23 3.33e-01 -1.17e-01 5.40e-01
Translation 292 6.39e-04 -1.16e-01 4.69e-03
DNA Damage/Telomere Stress Induced Senescence 33 2.50e-01 1.16e-01 4.49e-01
VLDLR internalisation and degradation 15 4.38e-01 1.16e-01 6.34e-01
Folding of actin by CCT/TriC 10 5.27e-01 -1.16e-01 7.04e-01
Bacterial Infection Pathways 63 1.13e-01 1.15e-01 2.58e-01
Gluconeogenesis 29 2.82e-01 -1.15e-01 4.86e-01
Carboxyterminal post-translational modifications of tubulin 31 2.66e-01 1.15e-01 4.64e-01
Signaling by FGFR3 in disease 16 4.26e-01 -1.15e-01 6.21e-01
Nuclear import of Rev protein 34 2.46e-01 1.15e-01 4.45e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 3.87e-01 1.15e-01 5.89e-01
TRAF3-dependent IRF activation pathway 13 4.76e-01 1.14e-01 6.66e-01
Signaling by BMP 23 3.44e-01 -1.14e-01 5.49e-01
PERK regulates gene expression 32 2.65e-01 1.14e-01 4.64e-01
Resolution of Abasic Sites (AP sites) 38 2.24e-01 1.14e-01 4.19e-01
Potential therapeutics for SARS 90 6.25e-02 1.14e-01 1.71e-01
SUMOylation of SUMOylation proteins 35 2.46e-01 1.13e-01 4.45e-01
Nuclear signaling by ERBB4 29 2.91e-01 1.13e-01 4.98e-01
Neurexins and neuroligins 38 2.28e-01 1.13e-01 4.22e-01
Signaling by Receptor Tyrosine Kinases 463 3.55e-05 1.13e-01 5.04e-04
RNA Polymerase II Transcription Termination 66 1.15e-01 1.12e-01 2.61e-01
Transcriptional Regulation by MECP2 49 1.76e-01 -1.12e-01 3.58e-01
Regulation of Expression and Function of Type II Classical Cadherins 29 2.98e-01 1.12e-01 5.03e-01
Regulation of Homotypic Cell-Cell Adhesion 29 2.98e-01 1.12e-01 5.03e-01
Formation of paraxial mesoderm 62 1.30e-01 -1.11e-01 2.89e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 38 2.35e-01 -1.11e-01 4.32e-01
Signaling by FGFR4 33 2.69e-01 -1.11e-01 4.67e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.55e-01 1.11e-01 4.54e-01
Biosynthesis of DHA-derived SPMs 13 4.88e-01 1.11e-01 6.76e-01
RHOG GTPase cycle 71 1.06e-01 1.11e-01 2.47e-01
p53-Dependent G1 DNA Damage Response 62 1.32e-01 -1.11e-01 2.92e-01
p53-Dependent G1/S DNA damage checkpoint 62 1.32e-01 -1.11e-01 2.92e-01
Activation of BH3-only proteins 29 3.04e-01 1.10e-01 5.06e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 4.92e-01 -1.10e-01 6.79e-01
RHOJ GTPase cycle 53 1.66e-01 1.10e-01 3.47e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 4.08e-01 -1.10e-01 6.09e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 4.08e-01 -1.10e-01 6.09e-01
Signaling by Non-Receptor Tyrosine Kinases 51 1.76e-01 1.09e-01 3.58e-01
Signaling by PTK6 51 1.76e-01 1.09e-01 3.58e-01
Cholesterol biosynthesis 27 3.26e-01 -1.09e-01 5.32e-01
Antigen processing-Cross presentation 92 7.30e-02 1.08e-01 1.91e-01
Transport of the SLBP independent Mature mRNA 35 2.68e-01 1.08e-01 4.67e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 16 4.55e-01 -1.08e-01 6.46e-01
Regulation of TNFR1 signaling 48 1.98e-01 -1.08e-01 3.86e-01
Disorders of Developmental Biology 12 5.20e-01 1.07e-01 7.02e-01
Disorders of Nervous System Development 12 5.20e-01 1.07e-01 7.02e-01
Loss of function of MECP2 in Rett syndrome 12 5.20e-01 1.07e-01 7.02e-01
Pervasive developmental disorders 12 5.20e-01 1.07e-01 7.02e-01
Regulation of CDH11 Expression and Function 27 3.35e-01 1.07e-01 5.40e-01
TP53 Regulates Transcription of Cell Cycle Genes 45 2.14e-01 1.07e-01 4.08e-01
Disease 1459 1.32e-11 1.07e-01 1.02e-09
G alpha (s) signalling events 85 8.84e-02 1.07e-01 2.16e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 5.21e-01 -1.07e-01 7.02e-01
Diseases associated with O-glycosylation of proteins 53 1.80e-01 1.06e-01 3.62e-01
Ca2+ pathway 54 1.76e-01 1.06e-01 3.58e-01
Nicotinate metabolism 28 3.31e-01 -1.06e-01 5.38e-01
APC/C:Cdc20 mediated degradation of Securin 66 1.36e-01 -1.06e-01 2.98e-01
Regulation of RUNX3 expression and activity 55 1.74e-01 -1.06e-01 3.56e-01
Signaling by SCF-KIT 38 2.61e-01 1.05e-01 4.61e-01
TCR signaling 99 7.05e-02 -1.05e-01 1.86e-01
HCMV Early Events 75 1.18e-01 1.04e-01 2.67e-01
Common Pathway of Fibrin Clot Formation 11 5.50e-01 1.04e-01 7.21e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.77e-01 1.04e-01 5.82e-01
Chaperone Mediated Autophagy 20 4.21e-01 -1.04e-01 6.18e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 2.39e-01 1.04e-01 4.37e-01
Downregulation of ERBB2 signaling 27 3.52e-01 -1.04e-01 5.59e-01
Interleukin-6 family signaling 20 4.23e-01 -1.03e-01 6.19e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 16 4.74e-01 1.03e-01 6.64e-01
Sema4D induced cell migration and growth-cone collapse 20 4.24e-01 1.03e-01 6.20e-01
Dual Incision in GG-NER 41 2.54e-01 1.03e-01 4.53e-01
Signalling to ERKs 32 3.15e-01 1.03e-01 5.18e-01
Signaling by FLT3 fusion proteins 19 4.39e-01 1.03e-01 6.34e-01
Pyroptosis 22 4.05e-01 1.03e-01 6.08e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 4.28e-01 1.02e-01 6.23e-01
IL-6-type cytokine receptor ligand interactions 14 5.08e-01 -1.02e-01 6.92e-01
Class B/2 (Secretin family receptors) 49 2.18e-01 1.02e-01 4.13e-01
Amine ligand-binding receptors 10 5.77e-01 1.02e-01 7.42e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 3.79e-01 1.02e-01 5.83e-01
rRNA modification in the nucleus and cytosol 59 1.78e-01 1.01e-01 3.60e-01
Death Receptor Signaling 147 3.45e-02 1.01e-01 1.15e-01
DNA Double Strand Break Response 44 2.46e-01 -1.01e-01 4.45e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 64 1.63e-01 1.01e-01 3.42e-01
SARS-CoV-2-host interactions 176 2.14e-02 1.01e-01 7.95e-02
Germ layer formation at gastrulation 10 5.82e-01 1.01e-01 7.46e-01
Cytochrome c-mediated apoptotic response 13 5.31e-01 -1.00e-01 7.07e-01
Metabolism of vitamins and cofactors 157 3.10e-02 -9.98e-02 1.06e-01
Formation of the beta-catenin:TCF transactivating complex 36 3.00e-01 -9.98e-02 5.05e-01
Synthesis of PIPs at the plasma membrane 50 2.23e-01 9.97e-02 4.18e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.90e-01 -9.94e-02 5.91e-01
Hedgehog ligand biogenesis 60 1.83e-01 -9.93e-02 3.67e-01
Signal transduction by L1 21 4.31e-01 9.93e-02 6.27e-01
Cell junction organization 91 1.03e-01 9.90e-02 2.40e-01
Cell-cell junction organization 66 1.66e-01 9.87e-02 3.47e-01
Clathrin-mediated endocytosis 128 5.47e-02 9.84e-02 1.56e-01
MyD88 cascade initiated on plasma membrane 93 1.01e-01 -9.84e-02 2.37e-01
Toll Like Receptor 10 (TLR10) Cascade 93 1.01e-01 -9.84e-02 2.37e-01
Toll Like Receptor 5 (TLR5) Cascade 93 1.01e-01 -9.84e-02 2.37e-01
Transcriptional regulation by RUNX3 95 9.79e-02 -9.83e-02 2.32e-01
Josephin domain DUBs 10 5.90e-01 -9.83e-02 7.52e-01
Cellular hexose transport 14 5.24e-01 9.83e-02 7.04e-01
Attachment and Entry 9694614 15 5.10e-01 9.82e-02 6.93e-01
NF-kB is activated and signals survival 13 5.42e-01 -9.76e-02 7.16e-01
Potassium Channels 54 2.16e-01 9.74e-02 4.11e-01
Prefoldin mediated transfer of substrate to CCT/TriC 24 4.10e-01 9.73e-02 6.09e-01
Downregulation of ERBB2:ERBB3 signaling 13 5.45e-01 -9.71e-02 7.19e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.83e-01 -9.71e-02 5.87e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.83e-01 -9.71e-02 5.87e-01
VEGFR2 mediated vascular permeability 27 3.84e-01 9.67e-02 5.88e-01
RHO GTPases Activate ROCKs 19 4.67e-01 9.64e-02 6.60e-01
Killing mechanisms 10 5.98e-01 -9.62e-02 7.58e-01
WNT5:FZD7-mediated leishmania damping 10 5.98e-01 -9.62e-02 7.58e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 4.92e-01 9.62e-02 6.79e-01
HIV Transcription Initiation 45 2.66e-01 -9.59e-02 4.64e-01
RNA Polymerase II HIV Promoter Escape 45 2.66e-01 -9.59e-02 4.64e-01
RNA Polymerase II Promoter Escape 45 2.66e-01 -9.59e-02 4.64e-01
RNA Polymerase II Transcription Initiation 45 2.66e-01 -9.59e-02 4.64e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 2.66e-01 -9.59e-02 4.64e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 2.66e-01 -9.59e-02 4.64e-01
SUMOylation of DNA damage response and repair proteins 77 1.46e-01 9.59e-02 3.13e-01
Senescence-Associated Secretory Phenotype (SASP) 55 2.19e-01 9.58e-02 4.15e-01
Transcriptional Regulation by NPAS4 31 3.56e-01 -9.57e-02 5.63e-01
Signaling by NOTCH4 81 1.37e-01 -9.56e-02 3.00e-01
Pyrimidine salvage 10 6.01e-01 9.55e-02 7.59e-01
Acyl chain remodelling of PS 15 5.22e-01 -9.55e-02 7.03e-01
PIP3 activates AKT signaling 243 1.05e-02 -9.55e-02 4.55e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 3.67e-01 9.51e-02 5.74e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 3.67e-01 9.51e-02 5.74e-01
RNA polymerase II transcribes snRNA genes 71 1.66e-01 -9.51e-02 3.47e-01
Signaling by ALK fusions and activated point mutants 54 2.27e-01 9.50e-02 4.22e-01
Signaling by ALK in cancer 54 2.27e-01 9.50e-02 4.22e-01
Downstream signaling of activated FGFR2 21 4.51e-01 -9.50e-02 6.44e-01
Nervous system development 507 2.74e-04 9.48e-02 2.44e-03
Axon guidance 487 3.59e-04 9.47e-02 2.99e-03
TNFR1-induced NF-kappa-B signaling pathway 33 3.46e-01 -9.47e-02 5.52e-01
G1/S DNA Damage Checkpoints 63 1.94e-01 -9.46e-02 3.83e-01
Downstream signaling of activated FGFR1 21 4.56e-01 -9.40e-02 6.48e-01
Drug ADME 59 2.12e-01 9.40e-02 4.06e-01
Signaling by FGFR3 33 3.50e-01 -9.40e-02 5.57e-01
Pregnenolone biosynthesis 10 6.08e-01 9.37e-02 7.64e-01
Glycerophospholipid biosynthesis 102 1.02e-01 -9.37e-02 2.39e-01
Nuclear Envelope (NE) Reassembly 67 1.85e-01 9.36e-02 3.71e-01
RAF-independent MAPK1/3 activation 20 4.71e-01 -9.32e-02 6.62e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 4.51e-01 -9.28e-02 6.44e-01
ERKs are inactivated 13 5.63e-01 -9.27e-02 7.29e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 5.21e-01 9.26e-02 7.02e-01
Metabolism 1742 2.33e-10 -9.26e-02 1.29e-08
Signaling by Interleukins 374 2.17e-03 9.26e-02 1.29e-02
Transcriptional regulation by RUNX1 162 4.25e-02 -9.25e-02 1.32e-01
SHC-mediated cascade:FGFR2 14 5.52e-01 9.19e-02 7.23e-01
G2/M Checkpoints 125 7.63e-02 9.19e-02 1.97e-01
Negative regulation of FGFR3 signaling 23 4.46e-01 -9.18e-02 6.41e-01
Viral Infection Pathways 653 7.11e-05 9.16e-02 8.96e-04
Signaling by FLT3 ITD and TKD mutants 15 5.40e-01 9.14e-02 7.14e-01
Platelet sensitization by LDL 17 5.15e-01 -9.13e-02 6.98e-01
RNA Polymerase III Chain Elongation 18 5.03e-01 -9.13e-02 6.87e-01
Cytokine Signaling in Immune system 577 1.98e-04 9.10e-02 1.86e-03
RHO GTPases activate PAKs 21 4.71e-01 9.10e-02 6.62e-01
GRB2 events in ERBB2 signaling 14 5.56e-01 -9.09e-02 7.26e-01
Protein-protein interactions at synapses 61 2.20e-01 9.09e-02 4.15e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 1.45e-01 -9.04e-02 3.13e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 5.62e-01 8.95e-02 7.29e-01
Retinoid metabolism and transport 28 4.14e-01 8.93e-02 6.14e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 5.49e-01 -8.93e-02 7.21e-01
Class I MHC mediated antigen processing & presentation 353 4.11e-03 -8.91e-02 2.18e-02
Plasma lipoprotein assembly 11 6.11e-01 8.87e-02 7.65e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 4.96e-01 8.80e-02 6.83e-01
COPI-independent Golgi-to-ER retrograde traffic 44 3.15e-01 8.76e-02 5.18e-01
Intracellular signaling by second messengers 279 1.20e-02 -8.76e-02 5.02e-02
Regulation of signaling by CBL 22 4.77e-01 8.76e-02 6.66e-01
RUNX2 regulates bone development 27 4.31e-01 8.76e-02 6.27e-01
Downstream signaling events of B Cell Receptor (BCR) 78 1.83e-01 -8.72e-02 3.67e-01
Formation of tubulin folding intermediates by CCT/TriC 20 5.00e-01 8.71e-02 6.86e-01
ATF4 activates genes in response to endoplasmic reticulum stress 27 4.36e-01 8.67e-02 6.31e-01
Constitutive Signaling by EGFRvIII 15 5.62e-01 -8.64e-02 7.29e-01
Signaling by EGFRvIII in Cancer 15 5.62e-01 -8.64e-02 7.29e-01
Chromatin modifying enzymes 203 3.46e-02 -8.61e-02 1.15e-01
Chromatin organization 203 3.46e-02 -8.61e-02 1.15e-01
STAT3 nuclear events downstream of ALK signaling 10 6.38e-01 8.60e-02 7.88e-01
O-linked glycosylation 84 1.76e-01 8.54e-02 3.58e-01
Processing of Capped Intronless Pre-mRNA 29 4.26e-01 8.54e-02 6.21e-01
MAPK1/MAPK3 signaling 237 2.38e-02 -8.54e-02 8.68e-02
RAF/MAP kinase cascade 232 2.57e-02 -8.51e-02 9.29e-02
G-protein mediated events 49 3.04e-01 8.50e-02 5.06e-01
NR1H2 and NR1H3-mediated signaling 39 3.61e-01 -8.46e-02 5.68e-01
Phase 2 - plateau phase 11 6.28e-01 -8.44e-02 7.82e-01
Metabolism of steroid hormones 21 5.04e-01 8.42e-02 6.89e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 6.46e-01 -8.40e-02 7.90e-01
FGFR2 ligand binding and activation 10 6.46e-01 -8.39e-02 7.90e-01
MASTL Facilitates Mitotic Progression 10 6.46e-01 -8.39e-02 7.90e-01
Budding and maturation of HIV virion 27 4.52e-01 -8.36e-02 6.45e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.14e-01 8.35e-02 6.14e-01
Ephrin signaling 19 5.30e-01 8.33e-02 7.06e-01
Trafficking of GluR2-containing AMPA receptors 14 5.90e-01 8.32e-02 7.52e-01
Acyl chain remodelling of PI 10 6.49e-01 -8.32e-02 7.93e-01
RHO GTPases activate PKNs 37 3.82e-01 8.31e-02 5.86e-01
NOTCH3 Intracellular Domain Regulates Transcription 21 5.10e-01 -8.30e-02 6.93e-01
Regulation of IFNG signaling 12 6.19e-01 8.29e-02 7.74e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 3.54e-01 8.27e-02 5.60e-01
Signaling by NOTCH2 29 4.41e-01 8.26e-02 6.36e-01
Elevation of cytosolic Ca2+ levels 13 6.07e-01 8.25e-02 7.63e-01
Negative regulation of FGFR1 signaling 25 4.79e-01 -8.19e-02 6.68e-01
Signaling by NTRKs 122 1.19e-01 8.18e-02 2.69e-01
SARS-CoV-2 modulates autophagy 11 6.39e-01 -8.16e-02 7.88e-01
IKK complex recruitment mediated by RIP1 23 5.01e-01 8.11e-02 6.86e-01
Signaling by FGFR4 in disease 10 6.59e-01 -8.07e-02 8.00e-01
TNF signaling 57 2.93e-01 -8.05e-02 4.99e-01
CLEC7A (Dectin-1) signaling 95 1.76e-01 -8.04e-02 3.58e-01
Metabolism of fat-soluble vitamins 31 4.40e-01 8.02e-02 6.35e-01
Regulation of PLK1 Activity at G2/M Transition 86 2.00e-01 8.01e-02 3.89e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.23e-01 8.00e-02 5.30e-01
tRNA modification in the nucleus and cytosol 43 3.66e-01 7.97e-02 5.74e-01
Mitotic Prophase 88 1.97e-01 7.96e-02 3.85e-01
Frs2-mediated activation 11 6.48e-01 -7.96e-02 7.92e-01
Interleukin-1 signaling 107 1.55e-01 -7.96e-02 3.27e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 55 3.09e-01 7.94e-02 5.12e-01
mRNA Capping 29 4.61e-01 -7.92e-02 6.52e-01
CDK-mediated phosphorylation and removal of Cdc6 70 2.54e-01 -7.89e-02 4.53e-01
SHC-mediated cascade:FGFR3 12 6.36e-01 7.89e-02 7.88e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 6.51e-01 -7.88e-02 7.94e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 5.86e-01 -7.87e-02 7.49e-01
SCF(Skp2)-mediated degradation of p27/p21 59 3.02e-01 -7.77e-02 5.06e-01
Cyclin E associated events during G1/S transition 81 2.29e-01 -7.74e-02 4.23e-01
MAPK6/MAPK4 signaling 83 2.24e-01 -7.72e-02 4.19e-01
Positive epigenetic regulation of rRNA expression 52 3.36e-01 7.71e-02 5.41e-01
Transcriptional regulation of white adipocyte differentiation 82 2.31e-01 -7.65e-02 4.26e-01
RET signaling 32 4.56e-01 -7.61e-02 6.48e-01
FRS-mediated FGFR4 signaling 14 6.24e-01 -7.56e-02 7.80e-01
Assembly of the pre-replicative complex 88 2.21e-01 -7.55e-02 4.16e-01
Oncogene Induced Senescence 33 4.53e-01 7.55e-02 6.45e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 6.81e-01 7.52e-02 8.14e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.93e-01 7.50e-02 7.53e-01
Base Excision Repair 50 3.60e-01 7.49e-02 5.67e-01
Regulation of beta-cell development 20 5.63e-01 -7.46e-02 7.29e-01
mRNA 3’-end processing 57 3.33e-01 7.42e-02 5.40e-01
Signaling by WNT 240 4.85e-02 -7.41e-02 1.42e-01
MET receptor recycling 10 6.86e-01 7.39e-02 8.18e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 5.08e-01 7.37e-02 6.92e-01
HDMs demethylate histones 21 5.60e-01 -7.36e-02 7.28e-01
Endogenous sterols 20 5.69e-01 -7.35e-02 7.36e-01
Oxidative Stress Induced Senescence 69 2.93e-01 -7.32e-02 4.99e-01
ISG15 antiviral mechanism 71 2.87e-01 -7.32e-02 4.92e-01
Free fatty acids regulate insulin secretion 10 6.90e-01 7.29e-02 8.20e-01
Generic Transcription Pathway 1082 6.39e-05 -7.26e-02 8.19e-04
NFE2L2 regulating anti-oxidant/detoxification enzymes 14 6.38e-01 -7.26e-02 7.88e-01
Orc1 removal from chromatin 67 3.05e-01 -7.25e-02 5.07e-01
NCAM1 interactions 31 4.86e-01 7.24e-02 6.75e-01
cGMP effects 14 6.40e-01 -7.23e-02 7.88e-01
Signaling by NOTCH1 71 2.94e-01 -7.21e-02 4.99e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 4.09e-01 -7.20e-02 6.09e-01
FLT3 Signaling 34 4.71e-01 7.15e-02 6.62e-01
MET activates RAS signaling 11 6.82e-01 7.14e-02 8.14e-01
TGF-beta receptor signaling activates SMADs 46 4.04e-01 7.12e-02 6.07e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 5.56e-01 7.10e-02 7.26e-01
Negative regulation of FGFR2 signaling 25 5.40e-01 -7.09e-02 7.14e-01
Estrogen-dependent gene expression 90 2.46e-01 -7.08e-02 4.45e-01
Signaling by NTRK1 (TRKA) 106 2.10e-01 7.05e-02 4.04e-01
Pre-NOTCH Expression and Processing 55 3.67e-01 7.03e-02 5.74e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 4.39e-01 6.99e-02 6.34e-01
Platelet calcium homeostasis 23 5.62e-01 6.98e-02 7.29e-01
Signaling by NOTCH3 45 4.18e-01 -6.98e-02 6.15e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 6.90e-01 6.95e-02 8.20e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 3.09e-01 -6.94e-02 5.12e-01
Deadenylation of mRNA 22 5.73e-01 -6.93e-02 7.38e-01
SUMOylation of transcription cofactors 44 4.26e-01 -6.93e-02 6.21e-01
FLT3 signaling in disease 27 5.38e-01 6.85e-02 7.13e-01
DNA Repair 281 4.86e-02 6.85e-02 1.42e-01
Regulation of MECP2 expression and activity 29 5.24e-01 -6.84e-02 7.04e-01
Cyclin A:Cdk2-associated events at S phase entry 83 2.83e-01 -6.82e-02 4.86e-01
EGFR downregulation 25 5.55e-01 -6.82e-02 7.26e-01
DCC mediated attractive signaling 13 6.71e-01 6.81e-02 8.08e-01
Biological oxidations 139 1.68e-01 -6.78e-02 3.48e-01
Formation of the Early Elongation Complex 33 5.01e-01 -6.77e-02 6.86e-01
Formation of the HIV-1 Early Elongation Complex 33 5.01e-01 -6.77e-02 6.86e-01
SUMOylation of transcription factors 16 6.41e-01 6.74e-02 7.88e-01
MAPK family signaling cascades 272 5.66e-02 -6.73e-02 1.61e-01
PI3K/AKT Signaling in Cancer 83 2.90e-01 -6.72e-02 4.97e-01
Retrograde transport at the Trans-Golgi-Network 49 4.17e-01 6.71e-02 6.14e-01
P2Y receptors 10 7.14e-01 -6.70e-02 8.36e-01
Signal Transduction 2020 1.17e-06 6.66e-02 2.43e-05
KSRP (KHSRP) binds and destabilizes mRNA 17 6.38e-01 6.59e-02 7.88e-01
Initial triggering of complement 15 6.59e-01 6.59e-02 8.00e-01
Gastrulation 85 2.96e-01 -6.57e-02 5.00e-01
IRAK1 recruits IKK complex 14 6.71e-01 -6.56e-02 8.08e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 6.71e-01 -6.56e-02 8.08e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 30 5.34e-01 -6.56e-02 7.10e-01
RHOD GTPase cycle 50 4.23e-01 6.56e-02 6.19e-01
Inwardly rectifying K+ channels 24 5.80e-01 6.53e-02 7.44e-01
NoRC negatively regulates rRNA expression 52 4.17e-01 6.51e-02 6.14e-01
S Phase 158 1.59e-01 6.50e-02 3.34e-01
Fc epsilon receptor (FCERI) signaling 126 2.08e-01 -6.50e-02 4.02e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 99 2.65e-01 -6.49e-02 4.64e-01
DNA Damage Bypass 46 4.49e-01 6.46e-02 6.43e-01
Interleukin-37 signaling 20 6.19e-01 6.43e-02 7.74e-01
SUMOylation of ubiquitinylation proteins 39 4.89e-01 6.40e-02 6.76e-01
Meiotic synapsis 31 5.40e-01 6.37e-02 7.14e-01
Activation of HOX genes during differentiation 66 3.71e-01 -6.37e-02 5.78e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 66 3.71e-01 -6.37e-02 5.78e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.70e-01 6.36e-02 8.08e-01
Regulation of HSF1-mediated heat shock response 79 3.29e-01 -6.36e-02 5.36e-01
RHOH GTPase cycle 31 5.41e-01 6.35e-02 7.15e-01
Signaling by PDGFRA extracellular domain mutants 12 7.05e-01 6.31e-02 8.29e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.05e-01 6.31e-02 8.29e-01
Regulation of RAS by GAPs 65 3.84e-01 -6.24e-02 5.88e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 4.16e-01 -6.23e-02 6.14e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 4.16e-01 -6.23e-02 6.14e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 4.16e-01 -6.23e-02 6.14e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 4.16e-01 -6.23e-02 6.14e-01
Signaling by NOTCH1 in Cancer 57 4.16e-01 -6.23e-02 6.14e-01
Heme signaling 44 4.76e-01 -6.22e-02 6.65e-01
PLC beta mediated events 45 4.73e-01 6.19e-02 6.64e-01
Surfactant metabolism 18 6.49e-01 6.19e-02 7.93e-01
C-type lectin receptors (CLRs) 121 2.40e-01 -6.18e-02 4.38e-01
Sensory perception of taste 15 6.80e-01 -6.14e-02 8.14e-01
Serotonin Neurotransmitter Release Cycle 13 7.02e-01 -6.12e-02 8.28e-01
Xenobiotics 10 7.39e-01 6.09e-02 8.50e-01
Glutamate Neurotransmitter Release Cycle 20 6.37e-01 6.09e-02 7.88e-01
Cytosolic sensors of pathogen-associated DNA 62 4.07e-01 6.09e-02 6.09e-01
Assembly Of The HIV Virion 16 6.75e-01 -6.06e-02 8.11e-01
Toll-like Receptor Cascades 154 1.95e-01 6.06e-02 3.83e-01
RNA Polymerase II Transcription 1200 5.09e-04 -6.01e-02 3.93e-03
Signaling by ROBO receptors 201 1.42e-01 6.01e-02 3.10e-01
Sialic acid metabolism 28 5.83e-01 6.00e-02 7.46e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 6.53e-01 -5.97e-02 7.95e-01
Toll Like Receptor 3 (TLR3) Cascade 102 3.01e-01 -5.93e-02 5.05e-01
Negative epigenetic regulation of rRNA expression 55 4.47e-01 5.93e-02 6.42e-01
MyD88 dependent cascade initiated on endosome 100 3.13e-01 -5.85e-02 5.16e-01
p75NTR recruits signalling complexes 13 7.16e-01 5.84e-02 8.37e-01
Interferon Signaling 165 1.97e-01 5.83e-02 3.85e-01
Transcription of the HIV genome 67 4.12e-01 -5.80e-02 6.12e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.73e-01 5.76e-02 7.38e-01
SUMOylation of DNA methylation proteins 16 6.90e-01 -5.76e-02 8.20e-01
RND2 GTPase cycle 36 5.50e-01 5.75e-02 7.22e-01
Activated NTRK2 signals through FRS2 and FRS3 10 7.54e-01 -5.73e-02 8.57e-01
Gene expression (Transcription) 1359 4.56e-04 -5.73e-02 3.58e-03
Formation of Incision Complex in GG-NER 43 5.17e-01 -5.71e-02 7.01e-01
RHOQ GTPase cycle 57 4.57e-01 5.69e-02 6.49e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 12 7.34e-01 -5.67e-02 8.48e-01
Export of Viral Ribonucleoproteins from Nucleus 33 5.74e-01 5.66e-02 7.38e-01
Blood group systems biosynthesis 13 7.28e-01 5.58e-02 8.45e-01
Norepinephrine Neurotransmitter Release Cycle 13 7.28e-01 -5.57e-02 8.45e-01
Regulation of TP53 Degradation 35 5.72e-01 -5.52e-02 7.38e-01
Signaling by ALK 26 6.27e-01 5.51e-02 7.81e-01
Signaling by FGFR1 40 5.48e-01 -5.49e-02 7.21e-01
Cargo recognition for clathrin-mediated endocytosis 89 3.71e-01 5.49e-02 5.78e-01
p75NTR signals via NF-kB 16 7.04e-01 5.48e-02 8.29e-01
Regulation of expression of SLITs and ROBOs 162 2.31e-01 5.46e-02 4.26e-01
TBC/RABGAPs 43 5.37e-01 -5.45e-02 7.13e-01
Metabolism of Angiotensinogen to Angiotensins 13 7.35e-01 5.43e-02 8.48e-01
Metabolism of lipids 609 2.35e-02 -5.40e-02 8.59e-02
Ion transport by P-type ATPases 42 5.48e-01 -5.36e-02 7.21e-01
Signaling by FGFR2 in disease 34 5.90e-01 -5.34e-02 7.52e-01
Processing of Capped Intron-Containing Pre-mRNA 278 1.26e-01 5.34e-02 2.83e-01
Dopamine Neurotransmitter Release Cycle 18 6.95e-01 -5.33e-02 8.23e-01
Reduction of cytosolic Ca++ levels 10 7.71e-01 5.33e-02 8.66e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 4.42e-01 -5.31e-02 6.37e-01
SUMOylation of RNA binding proteins 47 5.29e-01 5.31e-02 7.06e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 4.84e-01 5.27e-02 6.74e-01
Intrinsic Pathway for Apoptosis 53 5.08e-01 5.26e-02 6.92e-01
TRAF6 mediated NF-kB activation 22 6.70e-01 5.26e-02 8.08e-01
Detoxification of Reactive Oxygen Species 33 6.02e-01 5.25e-02 7.59e-01
Neurotransmitter receptors and postsynaptic signal transmission 143 2.79e-01 5.25e-02 4.82e-01
Signaling by Hippo 19 6.94e-01 5.22e-02 8.23e-01
mRNA Splicing - Major Pathway 202 2.02e-01 5.21e-02 3.93e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.34e-01 -5.20e-02 7.86e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 101 3.68e-01 -5.19e-02 5.74e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 5.90e-01 5.19e-02 7.52e-01
mRNA Splicing - Minor Pathway 50 5.27e-01 5.18e-02 7.04e-01
Tie2 Signaling 16 7.20e-01 -5.18e-02 8.41e-01
Visual phototransduction 55 5.09e-01 5.14e-02 6.93e-01
Signaling by TGF-beta Receptor Complex 92 3.96e-01 5.12e-02 5.99e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 3.74e-01 5.12e-02 5.80e-01
Nucleotide salvage 22 6.81e-01 5.07e-02 8.14e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 6.62e-01 -5.05e-02 8.03e-01
Regulation of TP53 Expression and Degradation 36 6.00e-01 -5.05e-02 7.59e-01
Viral Messenger RNA Synthesis 44 5.63e-01 5.04e-02 7.29e-01
Regulation of PTEN mRNA translation 11 7.73e-01 -5.03e-02 8.66e-01
TRP channels 20 6.97e-01 5.03e-02 8.23e-01
Post-translational protein modification 1190 3.88e-03 5.02e-02 2.11e-02
HCMV Infection 98 3.92e-01 5.01e-02 5.94e-01
AKT phosphorylates targets in the nucleus 10 7.85e-01 -4.99e-02 8.75e-01
Toll Like Receptor 9 (TLR9) Cascade 104 3.80e-01 -4.98e-02 5.84e-01
Interactions of Vpr with host cellular proteins 37 6.01e-01 4.98e-02 7.59e-01
Metabolism of steroids 120 3.50e-01 -4.95e-02 5.56e-01
Regulation of IFNA/IFNB signaling 11 7.77e-01 4.92e-02 8.70e-01
E2F mediated regulation of DNA replication 21 6.96e-01 -4.92e-02 8.23e-01
Adaptive Immune System 651 3.31e-02 4.92e-02 1.11e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 6.06e-01 4.91e-02 7.63e-01
Generation of second messenger molecules 17 7.26e-01 4.90e-02 8.45e-01
Packaging Of Telomere Ends 12 7.70e-01 -4.88e-02 8.66e-01
Spry regulation of FGF signaling 16 7.36e-01 -4.88e-02 8.49e-01
Nuclear Events (kinase and transcription factor activation) 57 5.25e-01 4.87e-02 7.04e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 106 3.87e-01 -4.86e-02 5.89e-01
Toll Like Receptor 2 (TLR2) Cascade 106 3.87e-01 -4.86e-02 5.89e-01
Toll Like Receptor TLR1:TLR2 Cascade 106 3.87e-01 -4.86e-02 5.89e-01
Toll Like Receptor TLR6:TLR2 Cascade 106 3.87e-01 -4.86e-02 5.89e-01
SHC1 events in ERBB4 signaling 12 7.71e-01 4.85e-02 8.66e-01
Translation initiation complex formation 58 5.26e-01 4.82e-02 7.04e-01
HCMV Late Events 59 5.24e-01 -4.80e-02 7.04e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 22 6.97e-01 4.79e-02 8.23e-01
SUMO E3 ligases SUMOylate target proteins 160 2.96e-01 4.79e-02 5.01e-01
VxPx cargo-targeting to cilium 17 7.33e-01 -4.78e-02 8.48e-01
Inositol phosphate metabolism 42 5.93e-01 -4.77e-02 7.53e-01
Anchoring fibril formation 14 7.58e-01 4.76e-02 8.60e-01
Synthesis of DNA 117 3.74e-01 4.76e-02 5.80e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 7.13e-01 4.76e-02 8.36e-01
RMTs methylate histone arginines 33 6.38e-01 -4.73e-02 7.88e-01
Rab regulation of trafficking 116 3.80e-01 4.73e-02 5.84e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 7.15e-01 -4.71e-02 8.37e-01
eNOS activation 11 7.91e-01 4.61e-02 8.79e-01
Defective pyroptosis 19 7.29e-01 4.60e-02 8.45e-01
RNA Polymerase II Pre-transcription Events 77 4.87e-01 -4.59e-02 6.75e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 72 5.02e-01 4.58e-02 6.87e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 6.10e-01 -4.54e-02 7.65e-01
HIV Transcription Elongation 42 6.10e-01 -4.54e-02 7.65e-01
Tat-mediated elongation of the HIV-1 transcript 42 6.10e-01 -4.54e-02 7.65e-01
Activated NOTCH1 Transmits Signal to the Nucleus 29 6.72e-01 4.54e-02 8.08e-01
WNT ligand biogenesis and trafficking 15 7.63e-01 4.50e-02 8.62e-01
Signaling by ERBB4 51 5.80e-01 4.48e-02 7.44e-01
PRC2 methylates histones and DNA 19 7.37e-01 -4.44e-02 8.50e-01
SHC1 events in ERBB2 signaling 20 7.32e-01 4.43e-02 8.47e-01
Tight junction interactions 17 7.52e-01 -4.42e-02 8.56e-01
Mitotic G1 phase and G1/S transition 144 3.63e-01 4.40e-02 5.70e-01
Developmental Biology 792 3.72e-02 4.38e-02 1.20e-01
SUMOylation 166 3.32e-01 4.37e-02 5.40e-01
Signaling by NTRK2 (TRKB) 22 7.24e-01 4.35e-02 8.43e-01
Interleukin-1 family signaling 134 3.88e-01 -4.33e-02 5.89e-01
TAK1-dependent IKK and NF-kappa-B activation 42 6.28e-01 4.32e-02 7.82e-01
RUNX3 regulates NOTCH signaling 14 7.81e-01 -4.29e-02 8.72e-01
DNA Replication Pre-Initiation 103 4.53e-01 -4.29e-02 6.45e-01
CaM pathway 31 6.82e-01 -4.26e-02 8.14e-01
Calmodulin induced events 31 6.82e-01 -4.26e-02 8.14e-01
Synthesis of IP3 and IP4 in the cytosol 22 7.30e-01 4.25e-02 8.46e-01
HIV elongation arrest and recovery 32 6.80e-01 -4.21e-02 8.14e-01
Pausing and recovery of HIV elongation 32 6.80e-01 -4.21e-02 8.14e-01
DNA methylation 10 8.18e-01 -4.21e-02 8.95e-01
FGFR2 mutant receptor activation 24 7.22e-01 -4.19e-02 8.42e-01
Synthesis of very long-chain fatty acyl-CoAs 19 7.52e-01 4.19e-02 8.56e-01
Transcriptional Regulation by TP53 343 1.87e-01 -4.16e-02 3.73e-01
Antiviral mechanism by IFN-stimulated genes 79 5.24e-01 -4.14e-02 7.04e-01
mRNA Splicing 210 3.03e-01 4.13e-02 5.06e-01
Adenylate cyclase inhibitory pathway 12 8.05e-01 -4.12e-02 8.85e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 7.39e-01 4.11e-02 8.50e-01
Maturation of nucleoprotein 9683610 11 8.14e-01 4.10e-02 8.92e-01
Mitotic G2-G2/M phases 187 3.35e-01 4.09e-02 5.40e-01
Signaling by FGFR1 in disease 32 6.89e-01 -4.08e-02 8.20e-01
Signaling by RAF1 mutants 37 6.68e-01 4.08e-02 8.08e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 71 5.54e-01 -4.06e-02 7.25e-01
Vitamin B5 (pantothenate) metabolism 16 7.80e-01 -4.03e-02 8.72e-01
Notch-HLH transcription pathway 28 7.12e-01 -4.03e-02 8.36e-01
Opioid Signalling 79 5.37e-01 4.02e-02 7.13e-01
TRAF6 mediated IRF7 activation 15 7.89e-01 3.99e-02 8.79e-01
Metabolic disorders of biological oxidation enzymes 23 7.41e-01 -3.98e-02 8.52e-01
Signaling by FGFR2 61 5.93e-01 -3.96e-02 7.53e-01
Deadenylation-dependent mRNA decay 50 6.30e-01 -3.94e-02 7.83e-01
Signaling by EGFR in Cancer 21 7.56e-01 -3.92e-02 8.58e-01
Translation of Structural Proteins 9683701 29 7.16e-01 3.91e-02 8.37e-01
Signaling by NOTCH 174 3.75e-01 -3.90e-02 5.80e-01
Activation of NMDA receptors and postsynaptic events 76 5.57e-01 -3.90e-02 7.27e-01
MyD88-independent TLR4 cascade 106 4.89e-01 -3.89e-02 6.76e-01
TRIF(TICAM1)-mediated TLR4 signaling 106 4.89e-01 -3.89e-02 6.76e-01
Dual incision in TC-NER 65 5.93e-01 3.84e-02 7.53e-01
Diseases of signal transduction by growth factor receptors and second messengers 392 1.93e-01 -3.84e-02 3.82e-01
Glucose metabolism 83 5.46e-01 -3.83e-02 7.20e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 21 7.62e-01 3.82e-02 8.62e-01
ER-Phagosome pathway 79 5.58e-01 3.82e-02 7.27e-01
Ras activation upon Ca2+ influx through NMDA receptor 16 7.95e-01 -3.75e-02 8.81e-01
Signaling by Erythropoietin 24 7.52e-01 -3.73e-02 8.56e-01
Defective Intrinsic Pathway for Apoptosis 21 7.70e-01 3.69e-02 8.66e-01
Nicotinamide salvaging 16 7.99e-01 -3.68e-02 8.83e-01
Methylation 13 8.21e-01 -3.62e-02 8.96e-01
Signaling by FGFR 70 6.01e-01 -3.61e-02 7.59e-01
Early SARS-CoV-2 Infection Events 32 7.24e-01 -3.61e-02 8.43e-01
Beta-catenin independent WNT signaling 133 4.73e-01 3.61e-02 6.64e-01
G2/M Transition 185 4.04e-01 3.56e-02 6.07e-01
Formation of RNA Pol II elongation complex 56 6.46e-01 -3.55e-02 7.90e-01
RNA Polymerase II Transcription Elongation 56 6.46e-01 -3.55e-02 7.90e-01
Constitutive Signaling by Aberrant PI3K in Cancer 56 6.46e-01 -3.55e-02 7.90e-01
Metabolism of non-coding RNA 53 6.59e-01 3.50e-02 8.00e-01
snRNP Assembly 53 6.59e-01 3.50e-02 8.00e-01
FRS-mediated FGFR3 signaling 14 8.21e-01 -3.50e-02 8.96e-01
Switching of origins to a post-replicative state 88 5.74e-01 -3.47e-02 7.38e-01
Metabolism of folate and pterines 17 8.05e-01 -3.47e-02 8.85e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.32e-01 3.46e-02 7.85e-01
Purine salvage 13 8.29e-01 3.46e-02 9.02e-01
Processing of Intronless Pre-mRNAs 20 7.89e-01 -3.45e-02 8.79e-01
Signaling by Nuclear Receptors 211 3.93e-01 -3.42e-02 5.94e-01
Inhibition of DNA recombination at telomere 26 7.64e-01 -3.40e-02 8.63e-01
Organelle biogenesis and maintenance 272 3.42e-01 3.35e-02 5.48e-01
Regulation of NF-kappa B signaling 18 8.06e-01 -3.34e-02 8.85e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 7.91e-01 3.34e-02 8.79e-01
Signaling by Hedgehog 138 5.00e-01 3.33e-02 6.86e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 7.40e-01 3.29e-02 8.52e-01
Nephrin family interactions 19 8.06e-01 3.26e-02 8.85e-01
DNA Replication 128 5.26e-01 3.25e-02 7.04e-01
Acetylcholine Neurotransmitter Release Cycle 11 8.53e-01 3.23e-02 9.14e-01
Cleavage of the damaged pyrimidine 20 8.03e-01 -3.23e-02 8.84e-01
Depyrimidination 20 8.03e-01 -3.23e-02 8.84e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 20 8.03e-01 -3.23e-02 8.84e-01
RNA Polymerase I Transcription Termination 30 7.61e-01 3.21e-02 8.61e-01
Negative regulators of DDX58/IFIH1 signaling 34 7.47e-01 -3.20e-02 8.54e-01
SHC-mediated cascade:FGFR4 12 8.50e-01 3.15e-02 9.13e-01
Costimulation by the CD28 family 49 7.04e-01 3.13e-02 8.29e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 82 6.25e-01 -3.12e-02 7.80e-01
B-WICH complex positively regulates rRNA expression 37 7.43e-01 3.12e-02 8.52e-01
Cleavage of the damaged purine 15 8.35e-01 3.10e-02 9.03e-01
Depurination 15 8.35e-01 3.10e-02 9.03e-01
Recognition and association of DNA glycosylase with site containing an affected purine 15 8.35e-01 3.10e-02 9.03e-01
Signaling by Insulin receptor 65 6.66e-01 3.09e-02 8.08e-01
FRS-mediated FGFR1 signaling 15 8.36e-01 3.08e-02 9.04e-01
RND1 GTPase cycle 36 7.52e-01 3.05e-02 8.56e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 8.50e-01 3.02e-02 9.13e-01
Glucagon signaling in metabolic regulation 25 7.94e-01 3.01e-02 8.81e-01
RNA Polymerase I Promoter Escape 37 7.55e-01 -2.96e-02 8.58e-01
LGI-ADAM interactions 11 8.65e-01 -2.96e-02 9.21e-01
Signaling by FGFR in disease 53 7.10e-01 -2.95e-02 8.34e-01
FGFR1 mutant receptor activation 25 7.99e-01 -2.95e-02 8.83e-01
Signaling by PDGFR in disease 20 8.20e-01 2.93e-02 8.96e-01
Host Interactions of HIV factors 125 5.72e-01 2.93e-02 7.38e-01
TNFR1-induced proapoptotic signaling 25 8.01e-01 2.92e-02 8.84e-01
Vpr-mediated nuclear import of PICs 34 7.69e-01 2.91e-02 8.66e-01
Voltage gated Potassium channels 19 8.27e-01 -2.90e-02 9.01e-01
Sensory Perception 148 5.47e-01 2.87e-02 7.21e-01
The phototransduction cascade 19 8.32e-01 2.81e-02 9.03e-01
Metabolism of RNA 695 2.21e-01 2.74e-02 4.16e-01
Ribosomal scanning and start codon recognition 58 7.22e-01 2.70e-02 8.42e-01
PCP/CE pathway 87 6.69e-01 -2.65e-02 8.08e-01
tRNA processing 109 6.33e-01 2.65e-02 7.85e-01
Regulation of APC/C activators between G1/S and early anaphase 78 6.92e-01 -2.60e-02 8.21e-01
Activation of RAC1 11 8.82e-01 -2.59e-02 9.34e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 8.01e-01 -2.58e-02 8.84e-01
RHOBTB2 GTPase cycle 23 8.35e-01 -2.51e-02 9.03e-01
Initiation of Nuclear Envelope (NE) Reformation 19 8.50e-01 2.50e-02 9.13e-01
Formation of Fibrin Clot (Clotting Cascade) 20 8.48e-01 2.48e-02 9.13e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 65 7.30e-01 -2.48e-02 8.46e-01
Suppression of phagosomal maturation 13 8.78e-01 2.47e-02 9.31e-01
Glutamate and glutamine metabolism 11 8.88e-01 2.45e-02 9.35e-01
Regulation of TP53 Activity through Phosphorylation 87 6.97e-01 2.42e-02 8.23e-01
Transcriptional regulation of granulopoiesis 33 8.16e-01 2.34e-02 8.94e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 8.64e-01 2.33e-02 9.21e-01
Neurodegenerative Diseases 18 8.64e-01 2.33e-02 9.21e-01
Regulation of PTEN gene transcription 60 7.56e-01 2.32e-02 8.58e-01
Transcriptional regulation by small RNAs 53 7.70e-01 2.32e-02 8.66e-01
Assembly and cell surface presentation of NMDA receptors 32 8.21e-01 -2.31e-02 8.96e-01
Metabolism of proteins 1631 1.27e-01 2.30e-02 2.84e-01
Erythropoietin activates RAS 13 8.87e-01 2.28e-02 9.35e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 69 7.47e-01 2.25e-02 8.54e-01
Platelet homeostasis 72 7.42e-01 2.25e-02 8.52e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 51 7.82e-01 -2.24e-02 8.73e-01
Synthesis of PE 12 8.93e-01 2.24e-02 9.38e-01
G1/S Transition 126 6.71e-01 2.20e-02 8.08e-01
MicroRNA (miRNA) biogenesis 25 8.49e-01 -2.19e-02 9.13e-01
Processing and activation of SUMO 10 9.06e-01 2.15e-02 9.48e-01
Signaling by BRAF and RAF1 fusions 59 7.78e-01 2.12e-02 8.71e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 7.48e-01 -2.10e-02 8.55e-01
FGFR2 alternative splicing 24 8.60e-01 2.08e-02 9.21e-01
Maturation of nucleoprotein 9694631 15 8.90e-01 2.07e-02 9.36e-01
Regulation of CDH11 function 10 9.11e-01 2.05e-02 9.51e-01
Phase II - Conjugation of compounds 67 7.72e-01 2.05e-02 8.66e-01
Cellular Senescence 131 6.88e-01 2.04e-02 8.19e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 25 8.62e-01 -2.01e-02 9.21e-01
Trafficking of AMPA receptors 25 8.62e-01 -2.01e-02 9.21e-01
PIWI-interacting RNA (piRNA) biogenesis 22 8.71e-01 2.00e-02 9.25e-01
Regulation of TP53 Activity 151 6.72e-01 -2.00e-02 8.08e-01
tRNA processing in the nucleus 59 7.92e-01 1.98e-02 8.80e-01
SUMOylation of chromatin organization proteins 57 7.98e-01 1.96e-02 8.83e-01
Cytosolic tRNA aminoacylation 24 8.68e-01 1.96e-02 9.23e-01
PKMTs methylate histone lysines 42 8.26e-01 -1.96e-02 9.01e-01
Programmed Cell Death 190 6.43e-01 1.95e-02 7.90e-01
Neuronal System 262 5.94e-01 1.92e-02 7.54e-01
Disorders of transmembrane transporters 136 7.00e-01 -1.91e-02 8.26e-01
Interleukin receptor SHC signaling 20 8.84e-01 1.89e-02 9.35e-01
Acyl chain remodelling of PC 19 8.86e-01 -1.89e-02 9.35e-01
Integration of energy metabolism 88 7.61e-01 -1.88e-02 8.61e-01
CD209 (DC-SIGN) signaling 20 8.85e-01 -1.87e-02 9.35e-01
Hedgehog ‘on’ state 82 7.71e-01 -1.86e-02 8.66e-01
Hedgehog ‘off’ state 104 7.46e-01 -1.84e-02 8.54e-01
Signaling by ERBB2 47 8.29e-01 1.82e-02 9.02e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 9.04e-01 -1.81e-02 9.46e-01
Signaling by cytosolic FGFR1 fusion mutants 18 8.97e-01 -1.77e-02 9.40e-01
NS1 Mediated Effects on Host Pathways 40 8.47e-01 1.76e-02 9.13e-01
Ovarian tumor domain proteases 35 8.57e-01 1.76e-02 9.18e-01
Signaling by TGFB family members 115 7.46e-01 1.75e-02 8.54e-01
Activation of AMPK downstream of NMDARs 21 8.90e-01 1.74e-02 9.36e-01
Gene Silencing by RNA 79 7.90e-01 1.74e-02 8.79e-01
Cellular responses to stimuli 700 4.48e-01 1.69e-02 6.42e-01
Oncogenic MAPK signaling 75 8.12e-01 1.59e-02 8.90e-01
Negative regulation of the PI3K/AKT network 89 7.96e-01 -1.58e-02 8.82e-01
Prolonged ERK activation events 13 9.22e-01 1.58e-02 9.60e-01
DAG and IP3 signaling 37 8.68e-01 -1.57e-02 9.23e-01
ESR-mediated signaling 151 7.47e-01 1.52e-02 8.54e-01
GABA synthesis, release, reuptake and degradation 11 9.31e-01 -1.51e-02 9.66e-01
Glycolysis 65 8.38e-01 1.47e-02 9.05e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 31 8.88e-01 -1.46e-02 9.35e-01
Aggrephagy 33 8.85e-01 -1.46e-02 9.35e-01
Netrin-1 signaling 41 8.72e-01 -1.45e-02 9.26e-01
Ion channel transport 135 7.76e-01 1.42e-02 8.69e-01
Stimuli-sensing channels 75 8.34e-01 -1.40e-02 9.03e-01
Nonhomologous End-Joining (NHEJ) 34 8.90e-01 -1.37e-02 9.36e-01
Signaling by EGFR 44 8.79e-01 -1.32e-02 9.31e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 9.34e-01 -1.32e-02 9.69e-01
APC/C-mediated degradation of cell cycle proteins 85 8.34e-01 1.32e-02 9.03e-01
Regulation of mitotic cell cycle 85 8.34e-01 1.32e-02 9.03e-01
Transmission across Chemical Synapses 187 7.59e-01 1.30e-02 8.60e-01
Aspirin ADME 15 9.31e-01 -1.29e-02 9.66e-01
Transport of small molecules 535 6.13e-01 1.28e-02 7.67e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 73 8.52e-01 -1.27e-02 9.13e-01
CD28 dependent PI3K/Akt signaling 20 9.28e-01 -1.17e-02 9.65e-01
Cellular responses to stress 692 6.04e-01 1.16e-02 7.61e-01
Base-Excision Repair, AP Site Formation 22 9.25e-01 -1.16e-02 9.63e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 12 9.46e-01 -1.14e-02 9.74e-01
Fatty acyl-CoA biosynthesis 31 9.14e-01 -1.12e-02 9.54e-01
GAB1 signalosome 13 9.48e-01 -1.04e-02 9.75e-01
Epigenetic regulation of gene expression 132 8.39e-01 1.03e-02 9.05e-01
Amino acids regulate mTORC1 49 9.02e-01 1.02e-02 9.45e-01
Toll Like Receptor 4 (TLR4) Cascade 134 8.46e-01 9.72e-03 9.12e-01
Translesion Synthesis by POLH 18 9.45e-01 -9.42e-03 9.74e-01
Post NMDA receptor activation events 65 8.96e-01 -9.41e-03 9.39e-01
Laminin interactions 30 9.29e-01 -9.41e-03 9.65e-01
Transcriptional regulation by RUNX2 113 8.63e-01 -9.39e-03 9.21e-01
FRS-mediated FGFR2 signaling 16 9.48e-01 -9.34e-03 9.75e-01
SIRT1 negatively regulates rRNA expression 14 9.54e-01 -8.92e-03 9.79e-01
Late Phase of HIV Life Cycle 132 8.62e-01 -8.77e-03 9.21e-01
Pre-NOTCH Transcription and Translation 39 9.27e-01 8.53e-03 9.64e-01
TNFR2 non-canonical NF-kB pathway 87 8.91e-01 8.50e-03 9.36e-01
Regulation of TP53 Activity through Acetylation 29 9.38e-01 8.37e-03 9.72e-01
Diseases of carbohydrate metabolism 29 9.39e-01 8.18e-03 9.72e-01
Inactivation, recovery and regulation of the phototransduction cascade 18 9.53e-01 7.98e-03 9.79e-01
Apoptosis 163 8.70e-01 7.41e-03 9.25e-01
Signaling by FGFR2 IIIa TM 19 9.56e-01 7.34e-03 9.79e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 9.08e-01 7.32e-03 9.49e-01
Aquaporin-mediated transport 36 9.40e-01 7.23e-03 9.72e-01
Regulation of NPAS4 gene expression 12 9.66e-01 -7.13e-03 9.83e-01
Downstream signal transduction 28 9.49e-01 -6.98e-03 9.75e-01
CTLA4 inhibitory signaling 18 9.61e-01 6.64e-03 9.82e-01
Cyclin D associated events in G1 47 9.43e-01 5.99e-03 9.74e-01
G1 Phase 47 9.43e-01 5.99e-03 9.74e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 9.60e-01 5.90e-03 9.82e-01
MECP2 regulates neuronal receptors and channels 14 9.70e-01 -5.72e-03 9.87e-01
Signaling by the B Cell Receptor (BCR) 104 9.21e-01 5.61e-03 9.60e-01
Apoptotic factor-mediated response 20 9.66e-01 5.55e-03 9.83e-01
NOD1/2 Signaling Pathway 36 9.55e-01 5.39e-03 9.79e-01
Nucleotide-like (purinergic) receptors 14 9.73e-01 5.28e-03 9.87e-01
RNA Polymerase I Promoter Clearance 56 9.46e-01 5.27e-03 9.74e-01
RNA Polymerase I Transcription 56 9.46e-01 5.27e-03 9.74e-01
RHOV GTPase cycle 34 9.65e-01 -4.29e-03 9.83e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 9.63e-01 4.19e-03 9.82e-01
Signaling by RAS mutants 41 9.63e-01 4.19e-03 9.82e-01
Signaling by moderate kinase activity BRAF mutants 41 9.63e-01 4.19e-03 9.82e-01
Signaling downstream of RAS mutants 41 9.63e-01 4.19e-03 9.82e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 9.73e-01 -4.13e-03 9.87e-01
RAS processing 22 9.75e-01 3.92e-03 9.87e-01
Amino acid transport across the plasma membrane 24 9.74e-01 3.83e-03 9.87e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.68e-01 -3.83e-03 9.85e-01
Cytochrome P450 - arranged by substrate type 35 9.72e-01 3.45e-03 9.87e-01
Phospholipid metabolism 179 9.39e-01 -3.30e-03 9.72e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.77e-01 -3.08e-03 9.87e-01
Tat-mediated HIV elongation arrest and recovery 30 9.77e-01 -3.08e-03 9.87e-01
Interleukin-2 family signaling 33 9.77e-01 -2.85e-03 9.87e-01
RNA Polymerase I Transcription Initiation 47 9.75e-01 -2.69e-03 9.87e-01
Cytosolic iron-sulfur cluster assembly 13 9.87e-01 -2.62e-03 9.94e-01
Neurotransmitter release cycle 35 9.86e-01 1.68e-03 9.94e-01
TP53 Regulates Transcription of DNA Repair Genes 61 9.82e-01 -1.66e-03 9.91e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 74 9.83e-01 -1.45e-03 9.91e-01
Ca-dependent events 33 9.90e-01 -1.28e-03 9.96e-01
HIV Infection 221 9.77e-01 1.14e-03 9.87e-01
Paracetamol ADME 19 9.94e-01 9.58e-04 9.98e-01
Association of TriC/CCT with target proteins during biosynthesis 35 9.92e-01 9.53e-04 9.98e-01
Signaling by KIT in disease 19 9.95e-01 -7.48e-04 9.98e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 9.95e-01 -7.48e-04 9.98e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 28 9.96e-01 5.14e-04 9.98e-01
Uptake and actions of bacterial toxins 24 9.97e-01 5.09e-04 9.98e-01
Nucleotide Excision Repair 110 9.97e-01 2.20e-04 9.98e-01
HIV Life Cycle 145 9.97e-01 1.65e-04 9.98e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 1.00e+00 5.32e-05 1.00e+00


Detailed Gene set reports



mitochondrial fatty acid beta-oxidation of saturated fatty acids

mitochondrial fatty acid beta-oxidation of saturated fatty acids
1443
set mitochondrial fatty acid beta-oxidation of saturated fatty acids
setSize 10
pANOVA 1.02e-05
s.dist -0.806
p.adjustANOVA 0.000178



Top enriched genes

Top 20 genes
GeneID Gene Rank
HADH -8636
ACADM -8447
ACADL -8338
ACADS -8292
HADHB -8192
ECHS1 -7513
ACADVL -7312
MECR -7258
HADHA -6853
ACSM3 -1568

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HADH -8636
ACADM -8447
ACADL -8338
ACADS -8292
HADHB -8192
ECHS1 -7513
ACADVL -7312
MECR -7258
HADHA -6853
ACSM3 -1568


Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
197
set Citric acid cycle (TCA cycle)
setSize 22
pANOVA 4.73e-10
s.dist -0.767
p.adjustANOVA 2.39e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDH2 -8567
ACO2 -8415
NNT -8363
SUCLA2 -8280
CS -8263
MDH2 -8249
SDHA -8177
DLD -8063
SDHD -8047
SDHB -7863
FH -7770
SUCLG2 -7307
IDH3A -7204
OGDH -7180
SUCLG1 -7068
IDH3B -6884
DLST -6568
SDHC -6031
ME2 -5467
IDH3G -4170

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDH2 -8567
ACO2 -8415
NNT -8363
SUCLA2 -8280
CS -8263
MDH2 -8249
SDHA -8177
DLD -8063
SDHD -8047
SDHB -7863
FH -7770
SUCLG2 -7307
IDH3A -7204
OGDH -7180
SUCLG1 -7068
IDH3B -6884
DLST -6568
SDHC -6031
ME2 -5467
IDH3G -4170
FAHD1 -3705
ME3 -478


Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation
494
set Glyoxylate metabolism and glycine degradation
setSize 23
pANOVA 1.93e-10
s.dist -0.767
p.adjustANOVA 1.13e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
GOT2 -8442
ALDH4A1 -8325
PDHX -8293
DLD -8063
DLAT -7956
PDHA1 -7882
PXMP2 -7640
NDUFAB1 -7443
PDHB -7423
DBT -7252
OGDH -7180
DHTKD1 -6969
GCSH -6940
DDO -6893
LIAS -6797
BCKDHB -6744
DLST -6568
BCKDHA -6476
LIPT2 -6407
GRHPR -6115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GOT2 -8442
ALDH4A1 -8325
PDHX -8293
DLD -8063
DLAT -7956
PDHA1 -7882
PXMP2 -7640
NDUFAB1 -7443
PDHB -7423
DBT -7252
OGDH -7180
DHTKD1 -6969
GCSH -6940
DDO -6893
LIAS -6797
BCKDHB -6744
DLST -6568
BCKDHA -6476
LIPT2 -6407
GRHPR -6115
HOGA1 -5659
AMT -4317
LIPT1 -3225


Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation
45
set Activation of PPARGC1A (PGC-1alpha) by phosphorylation
setSize 10
pANOVA 0.000112
s.dist -0.706
p.adjustANOVA 0.00128



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAA2 -8749
MAPK12 -8740
PPARGC1A -8714
PRKAG3 -8607
PRKAB2 -7748
MAPK14 -7466
PRKAG1 -5563
PRKAB1 -4762
MAPK11 -3624
PRKAG2 -159

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAA2 -8749
MAPK12 -8740
PPARGC1A -8714
PRKAG3 -8607
PRKAB2 -7748
MAPK14 -7466
PRKAG1 -5563
PRKAB1 -4762
MAPK11 -3624
PRKAG2 -159


Branched-chain amino acid catabolism

Branched-chain amino acid catabolism
123
set Branched-chain amino acid catabolism
setSize 21
pANOVA 5.04e-08
s.dist -0.687
p.adjustANOVA 1.42e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAT1 -8377
ALDH6A1 -8320
ACADSB -8299
PPM1K -8224
HIBADH -8067
DLD -8063
MCCC2 -8014
IVD -7626
ECHS1 -7513
HIBCH -7366
DBT -7252
AUH -7199
ACAD8 -6942
MCCC1 -6928
BCAT2 -6924
BCKDHB -6744
BCKDHA -6476
BCKDK -6153
SLC25A44 -4546
HSD17B10 452

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAT1 -8377
ALDH6A1 -8320
ACADSB -8299
PPM1K -8224
HIBADH -8067
DLD -8063
MCCC2 -8014
IVD -7626
ECHS1 -7513
HIBCH -7366
DBT -7252
AUH -7199
ACAD8 -6942
MCCC1 -6928
BCAT2 -6924
BCKDHB -6744
BCKDHA -6476
BCKDK -6153
SLC25A44 -4546
HSD17B10 452
BCAT1 7232


Zinc transporters

Zinc transporters
1429
set Zinc transporters
setSize 10
pANOVA 0.000169
s.dist 0.687
p.adjustANOVA 0.00169



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC39A6 6912
SLC39A7 6824
SLC39A14 6450
SLC39A1 6124
SLC30A1 5760
SLC39A3 5503
SLC30A5 5292
SLC39A10 4451
SLC39A8 2510
SLC39A4 1180

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC39A6 6912
SLC39A7 6824
SLC39A14 6450
SLC39A1 6124
SLC30A1 5760
SLC39A3 5503
SLC30A5 5292
SLC39A10 4451
SLC39A8 2510
SLC39A4 1180


Complex I biogenesis

Complex I biogenesis
214
set Complex I biogenesis
setSize 51
pANOVA 8.21e-17
s.dist -0.674
p.adjustANOVA 1.09e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFAF6 -8436
NDUFS1 -8163
NDUFA7 -8088
NDUFB9 -8029
NDUFC1 -8022
NDUFA5 -7960
NDUFS2 -7950
NDUFS7 -7879
NDUFA9 -7714
NDUFB5 -7587
NDUFB10 -7538
NDUFV2 -7512
NDUFV1 -7463
NDUFAB1 -7443
NDUFA10 -7377
ECSIT -7360
NDUFV3 -7200
TIMMDC1 -7093
COA1 -7087
NDUFAF5 -7041

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFAF6 -8436
NDUFS1 -8163
NDUFA7 -8088
NDUFB9 -8029
NDUFC1 -8022
NDUFA5 -7960
NDUFS2 -7950
NDUFS7 -7879
NDUFA9 -7714
NDUFB5 -7587
NDUFB10 -7538
NDUFV2 -7512
NDUFV1 -7463
NDUFAB1 -7443
NDUFA10 -7377
ECSIT -7360
NDUFV3 -7200
TIMMDC1 -7093
COA1 -7087
NDUFAF5 -7041
NDUFA3 -7012
NDUFB11 -6939
NDUFS3 -6909
NDUFA12 -6847
NDUFB4 -6809
NDUFA8 -6784
NDUFB3 -6767
NDUFS4 -6624
NDUFC2 -6589
NDUFAF4 -6583
NDUFB8 -6332
NDUFB6 -6277
NDUFS8 -6033
NDUFA6 -5874
NDUFB7 -5817
NDUFA2 -5747
NDUFB1 -5677
NDUFAF1 -5597
NDUFAF7 -5386
NDUFA1 -5188
NDUFB2 -5120
NDUFS6 -4682
ACAD9 -4525
NDUFAF3 -4455
NDUFA13 -4265
TMEM186 -4244
NUBPL -2752
NDUFS5 -2029
NDUFA11 -1810
NDUFAF2 -869
TMEM126B 550


Mucopolysaccharidoses

Mucopolysaccharidoses
718
set Mucopolysaccharidoses
setSize 11
pANOVA 0.000116
s.dist 0.671
p.adjustANOVA 0.00129



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDS 7532
GUSB 6877
ARSB 6208
HGSNAT 5508
NAGLU 5252
GALNS 5027
GLB1 4895
GNS 3883
IDUA 3773
SGSH 3123
HYAL1 2590

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDS 7532
GUSB 6877
ARSB 6208
HGSNAT 5508
NAGLU 5252
GALNS 5027
GLB1 4895
GNS 3883
IDUA 3773
SGSH 3123
HYAL1 2590


Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
319
set Dissolution of Fibrin Clot
setSize 10
pANOVA 0.000284
s.dist 0.663
p.adjustANOVA 0.00246



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A10 7622
PLAUR 7521
ANXA2 7320
SERPINE1 6794
SERPINB8 6449
PLAU 5931
SERPINE2 5569
SERPINB6 5003
SERPINF2 -354
PLAT -2824

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A10 7622
PLAUR 7521
ANXA2 7320
SERPINE1 6794
SERPINB8 6449
PLAU 5931
SERPINE2 5569
SERPINB6 5003
SERPINF2 -354
PLAT -2824


Respiratory electron transport

Respiratory electron transport
1074
set Respiratory electron transport
setSize 93
pANOVA 8.63e-27
s.dist -0.642
p.adjustANOVA 4.21e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
COQ10A -8605
NDUFAF6 -8436
ETFDH -8346
UQCR10 -8339
COX5A -8196
SDHA -8177
NDUFS1 -8163
UQCRFS1 -8128
NDUFA7 -8088
CYC1 -8079
SDHD -8047
NDUFB9 -8029
NDUFC1 -8022
UQCRC2 -8005
CYCS -7961
NDUFA5 -7960
NDUFS2 -7950
NDUFS7 -7879
SDHB -7863
NDUFA4 -7839

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COQ10A -8605
NDUFAF6 -8436
ETFDH -8346
UQCR10 -8339
COX5A -8196
SDHA -8177
NDUFS1 -8163
UQCRFS1 -8128
NDUFA7 -8088
CYC1 -8079
SDHD -8047
NDUFB9 -8029
NDUFC1 -8022
UQCRC2 -8005
CYCS -7961
NDUFA5 -7960
NDUFS2 -7950
NDUFS7 -7879
SDHB -7863
NDUFA4 -7839
NDUFA9 -7714
ETFA -7597
TRAP1 -7596
NDUFB5 -7587
NDUFB10 -7538
NDUFV2 -7512
COX11 -7499
NDUFV1 -7463
LRPPRC -7448
NDUFAB1 -7443
COX5B -7427
UQCRC1 -7412
NDUFA10 -7377
ECSIT -7360
COX7B -7342
UQCRB -7290
NDUFV3 -7200
COX8A -7195
TIMMDC1 -7093
COA1 -7087
UQCR11 -7046
NDUFAF5 -7041
COX14 -7015
NDUFA3 -7012
COX7C -7006
NDUFB11 -6939
NDUFS3 -6909
NDUFA12 -6847
NDUFB4 -6809
NDUFA8 -6784
NDUFB3 -6767
TACO1 -6732
COX6C -6687
NDUFS4 -6624
ETFB -6591
NDUFC2 -6589
NDUFAF4 -6583
UQCRQ -6446
NDUFB8 -6332
NDUFB6 -6277
COX6B1 -6167
NDUFS8 -6033
SDHC -6031
NDUFA6 -5874
COX4I1 -5866
NDUFB7 -5817
NDUFA2 -5747
NDUFB1 -5677
NDUFAF1 -5597
NDUFAF7 -5386
NDUFA1 -5188
NDUFB2 -5120
UQCRH -5025
COX18 -4716
SURF1 -4695
NDUFS6 -4682
ACAD9 -4525
NDUFAF3 -4455
NDUFA13 -4265
TMEM186 -4244
SCO1 -3889
COX16 -3802
COX19 -3599
NUBPL -2752
NDUFS5 -2029
NDUFA11 -1810
NDUFAF2 -869
COX7A2L -296
TMEM126B 550
COX20 2661
COX6A1 6342
COQ10B 7152
SCO2 7495


Diseases associated with N-glycosylation of proteins

Diseases associated with N-glycosylation of proteins
302
set Diseases associated with N-glycosylation of proteins
setSize 20
pANOVA 8.79e-07
s.dist 0.635
p.adjustANOVA 1.92e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
ALG2 7175
MPDU1 6848
MAN1B1 6846
ALG8 6478
MGAT2 6347
B4GALT1 5766
ALG1 5076
ALG14 4941
GLB1 4895
MOGS 4881
RFT1 4565
ALG3 4294
ALG9 4190
ALG11 4099
ALG13 3864
CTSA 3802
NEU1 3577
DPAGT1 3489
ALG12 3182
ALG6 -923

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ALG2 7175
MPDU1 6848
MAN1B1 6846
ALG8 6478
MGAT2 6347
B4GALT1 5766
ALG1 5076
ALG14 4941
GLB1 4895
MOGS 4881
RFT1 4565
ALG3 4294
ALG9 4190
ALG11 4099
ALG13 3864
CTSA 3802
NEU1 3577
DPAGT1 3489
ALG12 3182
ALG6 -923


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
406
set Formation of ATP by chemiosmotic coupling
setSize 16
pANOVA 1.15e-05
s.dist -0.633
p.adjustANOVA 0.000196



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5F1A -7847
ATP5MC1 -7806
ATP5F1B -7735
ATP5F1D -7668
ATP5MC2 -7465
ATP5PF -7328
ATP5PO -7324
ATP5MC3 -7189
DMAC2L -6580
ATP5PB -6254
ATP5F1C -6157
ATP5PD -5326
ATP5MG -5155
ATP5MF -3044
ATP5ME -2219
ATP5F1E 2069

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5F1A -7847
ATP5MC1 -7806
ATP5F1B -7735
ATP5F1D -7668
ATP5MC2 -7465
ATP5PF -7328
ATP5PO -7324
ATP5MC3 -7189
DMAC2L -6580
ATP5PB -6254
ATP5F1C -6157
ATP5PD -5326
ATP5MG -5155
ATP5MF -3044
ATP5ME -2219
ATP5F1E 2069


Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1075
set Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
setSize 113
pANOVA 6.36e-31
s.dist -0.629
p.adjustANOVA 4.65e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
UCP3 -8783
COQ10A -8605
NDUFAF6 -8436
ETFDH -8346
UQCR10 -8339
COX5A -8196
SDHA -8177
NDUFS1 -8163
UQCRFS1 -8128
NDUFA7 -8088
CYC1 -8079
SDHD -8047
NDUFB9 -8029
NDUFC1 -8022
UQCRC2 -8005
CYCS -7961
NDUFA5 -7960
NDUFS2 -7950
NDUFS7 -7879
SDHB -7863

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UCP3 -8783
COQ10A -8605
NDUFAF6 -8436
ETFDH -8346
UQCR10 -8339
COX5A -8196
SDHA -8177
NDUFS1 -8163
UQCRFS1 -8128
NDUFA7 -8088
CYC1 -8079
SDHD -8047
NDUFB9 -8029
NDUFC1 -8022
UQCRC2 -8005
CYCS -7961
NDUFA5 -7960
NDUFS2 -7950
NDUFS7 -7879
SDHB -7863
ATP5F1A -7847
NDUFA4 -7839
ATP5MC1 -7806
ATP5F1B -7735
NDUFA9 -7714
ATP5F1D -7668
ETFA -7597
TRAP1 -7596
NDUFB5 -7587
NDUFB10 -7538
NDUFV2 -7512
COX11 -7499
ATP5MC2 -7465
NDUFV1 -7463
LRPPRC -7448
NDUFAB1 -7443
COX5B -7427
UQCRC1 -7412
NDUFA10 -7377
ECSIT -7360
COX7B -7342
ATP5PF -7328
ATP5PO -7324
UQCRB -7290
NDUFV3 -7200
COX8A -7195
ATP5MC3 -7189
TIMMDC1 -7093
COA1 -7087
UQCR11 -7046
NDUFAF5 -7041
COX14 -7015
NDUFA3 -7012
COX7C -7006
SLC25A27 -6963
NDUFB11 -6939
NDUFS3 -6909
NDUFA12 -6847
NDUFB4 -6809
NDUFA8 -6784
NDUFB3 -6767
TACO1 -6732
COX6C -6687
NDUFS4 -6624
ETFB -6591
NDUFC2 -6589
NDUFAF4 -6583
DMAC2L -6580
UQCRQ -6446
NDUFB8 -6332
NDUFB6 -6277
ATP5PB -6254
COX6B1 -6167
ATP5F1C -6157
NDUFS8 -6033
SDHC -6031
NDUFA6 -5874
COX4I1 -5866
NDUFB7 -5817
NDUFA2 -5747
NDUFB1 -5677
NDUFAF1 -5597
NDUFAF7 -5386
ATP5PD -5326
NDUFA1 -5188
ATP5MG -5155
NDUFB2 -5120
UQCRH -5025
COX18 -4716
SURF1 -4695
NDUFS6 -4682
ACAD9 -4525
NDUFAF3 -4455
NDUFA13 -4265
TMEM186 -4244
SCO1 -3889
COX16 -3802
COX19 -3599
ATP5MF -3044
NUBPL -2752
ATP5ME -2219
NDUFS5 -2029
NDUFA11 -1810
NDUFAF2 -869
UCP2 -866
COX7A2L -296
TMEM126B 550
ATP5F1E 2069
COX20 2661
SLC25A14 5463
COX6A1 6342
COQ10B 7152
SCO2 7495


The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport
1324
set The citric acid (TCA) cycle and respiratory electron transport
setSize 160
pANOVA 4.58e-41
s.dist -0.614
p.adjustANOVA 6.7e-38



Top enriched genes

Top 20 genes
GeneID Gene Rank
UCP3 -8783
COQ10A -8605
PDK4 -8572
IDH2 -8567
PDK2 -8545
ADHFE1 -8464
NDUFAF6 -8436
ACO2 -8415
NNT -8363
ETFDH -8346
UQCR10 -8339
PDHX -8293
SUCLA2 -8280
CS -8263
MDH2 -8249
COX5A -8196
SDHA -8177
NDUFS1 -8163
UQCRFS1 -8128
LDHB -8113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UCP3 -8783
COQ10A -8605
PDK4 -8572
IDH2 -8567
PDK2 -8545
ADHFE1 -8464
NDUFAF6 -8436
ACO2 -8415
NNT -8363
ETFDH -8346
UQCR10 -8339
PDHX -8293
SUCLA2 -8280
CS -8263
MDH2 -8249
COX5A -8196
SDHA -8177
NDUFS1 -8163
UQCRFS1 -8128
LDHB -8113
L2HGDH -8096
NDUFA7 -8088
CYC1 -8079
DLD -8063
SDHD -8047
NDUFB9 -8029
NDUFC1 -8022
UQCRC2 -8005
CYCS -7961
NDUFA5 -7960
DLAT -7956
NDUFS2 -7950
PDHA1 -7882
NDUFS7 -7879
SDHB -7863
ATP5F1A -7847
NDUFA4 -7839
ATP5MC1 -7806
FH -7770
ATP5F1B -7735
NDUFA9 -7714
ATP5F1D -7668
VDAC1 -7655
ETFA -7597
TRAP1 -7596
NDUFB5 -7587
NDUFB10 -7538
NDUFV2 -7512
COX11 -7499
ATP5MC2 -7465
NDUFV1 -7463
LRPPRC -7448
NDUFAB1 -7443
COX5B -7427
PDHB -7423
UQCRC1 -7412
MPC1 -7408
NDUFA10 -7377
GLO1 -7371
ECSIT -7360
COX7B -7342
ATP5PF -7328
ATP5PO -7324
HAGH -7315
SUCLG2 -7307
UQCRB -7290
IDH3A -7204
NDUFV3 -7200
COX8A -7195
ATP5MC3 -7189
OGDH -7180
TIMMDC1 -7093
COA1 -7087
SUCLG1 -7068
UQCR11 -7046
NDUFAF5 -7041
COX14 -7015
NDUFA3 -7012
COX7C -7006
SLC25A27 -6963
NDUFB11 -6939
NDUFS3 -6909
IDH3B -6884
NDUFA12 -6847
NDUFB4 -6809
NDUFA8 -6784
NDUFB3 -6767
PDP1 -6745
TACO1 -6732
COX6C -6687
MPC2 -6639
NDUFS4 -6624
ETFB -6591
NDUFC2 -6589
NDUFAF4 -6583
DMAC2L -6580
DLST -6568
UQCRQ -6446
NDUFB8 -6332
NDUFB6 -6277
ATP5PB -6254
COX6B1 -6167
ATP5F1C -6157
NDUFS8 -6033
SDHC -6031
NDUFA6 -5874
COX4I1 -5866
GSTZ1 -5852
NDUFB7 -5817
NDUFA2 -5747
NDUFB1 -5677
NDUFAF1 -5597
RXRA -5505
ME2 -5467
NDUFAF7 -5386
ATP5PD -5326
NDUFA1 -5188
ATP5MG -5155
D2HGDH -5130
NDUFB2 -5120
UQCRH -5025
PDP2 -4721
COX18 -4716
SURF1 -4695
NDUFS6 -4682
ACAD9 -4525
NDUFAF3 -4455
NDUFA13 -4265
TMEM186 -4244
IDH3G -4170
SCO1 -3889
COX16 -3802
FAHD1 -3705
COX19 -3599
PPARD -3230
ATP5MF -3044
PDPR -2878
NUBPL -2752
ME1 -2288
BSG -2232
ATP5ME -2219
NDUFS5 -2029
NDUFA11 -1810
SLC16A1 -964
NDUFAF2 -869
UCP2 -866
ME3 -478
COX7A2L -296
TMEM126B 550
ATP5F1E 2069
SLC16A8 2306
COX20 2661
PDK1 3632
LDHA 3877
SLC25A14 5463
PDK3 6195
COX6A1 6342
COQ10B 7152
SLC16A3 7196
SCO2 7495


CS/DS degradation

CS/DS degradation
143
set CS/DS degradation
setSize 11
pANOVA 0.00043
s.dist 0.613
p.adjustANOVA 0.00345



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDS 7532
CSPG4 7275
HEXB 6858
ARSB 6208
HEXA 4675
BGN 4106
IDUA 3773
HYAL3 3711
VCAN 3538
HYAL1 2590
DCN -862

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDS 7532
CSPG4 7275
HEXB 6858
ARSB 6208
HEXA 4675
BGN 4106
IDUA 3773
HYAL3 3711
VCAN 3538
HYAL1 2590
DCN -862


The activation of arylsulfatases

The activation of arylsulfatases
1323
set The activation of arylsulfatases
setSize 10
pANOVA 0.00111
s.dist 0.596
p.adjustANOVA 0.00732



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARSI 7190
ARSJ 6402
ARSB 6208
SUMF1 6136
SUMF2 5616
ARSK 4381
ARSG 3546
ARSD 3028
ARSA 2158
STS -1187

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARSI 7190
ARSJ 6402
ARSB 6208
SUMF1 6136
SUMF2 5616
ARSK 4381
ARSG 3546
ARSD 3028
ARSA 2158
STS -1187


Glycogen synthesis

Glycogen synthesis
490
set Glycogen synthesis
setSize 13
pANOVA 0.000209
s.dist -0.594
p.adjustANOVA 0.00196



Top enriched genes

Top 20 genes
GeneID Gene Rank
GYS1 -8633
EPM2A -8541
GYG1 -8488
PGM1 -8470
PPP1R3C -8211
UGP2 -6746
UBB -6415
GYG2 -6235
UBC -5441
GBE1 -4957
NHLRC1 -2245
UBA52 -382
RPS27A 3414

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GYS1 -8633
EPM2A -8541
GYG1 -8488
PGM1 -8470
PPP1R3C -8211
UGP2 -6746
UBB -6415
GYG2 -6235
UBC -5441
GBE1 -4957
NHLRC1 -2245
UBA52 -382
RPS27A 3414


Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle
915
set Pyruvate metabolism and Citric Acid (TCA) cycle
setSize 51
pANOVA 2.76e-13
s.dist -0.591
p.adjustANOVA 2.52e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDK4 -8572
IDH2 -8567
PDK2 -8545
ADHFE1 -8464
ACO2 -8415
NNT -8363
PDHX -8293
SUCLA2 -8280
CS -8263
MDH2 -8249
SDHA -8177
LDHB -8113
L2HGDH -8096
DLD -8063
SDHD -8047
DLAT -7956
PDHA1 -7882
SDHB -7863
FH -7770
VDAC1 -7655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDK4 -8572
IDH2 -8567
PDK2 -8545
ADHFE1 -8464
ACO2 -8415
NNT -8363
PDHX -8293
SUCLA2 -8280
CS -8263
MDH2 -8249
SDHA -8177
LDHB -8113
L2HGDH -8096
DLD -8063
SDHD -8047
DLAT -7956
PDHA1 -7882
SDHB -7863
FH -7770
VDAC1 -7655
PDHB -7423
MPC1 -7408
GLO1 -7371
HAGH -7315
SUCLG2 -7307
IDH3A -7204
OGDH -7180
SUCLG1 -7068
IDH3B -6884
PDP1 -6745
MPC2 -6639
DLST -6568
SDHC -6031
GSTZ1 -5852
RXRA -5505
ME2 -5467
D2HGDH -5130
PDP2 -4721
IDH3G -4170
FAHD1 -3705
PPARD -3230
PDPR -2878
ME1 -2288
BSG -2232
SLC16A1 -964
ME3 -478
SLC16A8 2306
PDK1 3632
LDHA 3877
PDK3 6195
SLC16A3 7196


Syndecan interactions

Syndecan interactions
1256
set Syndecan interactions
setSize 26
pANOVA 3.93e-07
s.dist 0.575
p.adjustANOVA 9.27e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL5A2 7400
ITGAV 7360
SDC2 7344
COL5A3 7207
TGFB1 7199
TNC 7009
ITGB1 6839
COL1A1 6748
COL5A1 6736
ITGB5 6689
COL3A1 6479
PRKCA 6107
COL1A2 5750
FN1 5631
CASK 5336
ACTN1 5090
SDC1 3054
ITGB3 2953
TRAPPC4 2453
ITGA2 1149

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL5A2 7400
ITGAV 7360
SDC2 7344
COL5A3 7207
TGFB1 7199
TNC 7009
ITGB1 6839
COL1A1 6748
COL5A1 6736
ITGB5 6689
COL3A1 6479
PRKCA 6107
COL1A2 5750
FN1 5631
CASK 5336
ACTN1 5090
SDC1 3054
ITGB3 2953
TRAPPC4 2453
ITGA2 1149
SDC3 846
FGF2 706
SDC4 186
THBS1 -1647
ITGB4 -1667
ITGA6 -4568


Carnitine metabolism

Carnitine metabolism
161
set Carnitine metabolism
setSize 14
pANOVA 0.000214
s.dist -0.571
p.adjustANOVA 0.00199



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKAA2 -8749
CPT1B -8667
ACACB -8428
SLC22A5 -8199
PRKAB2 -7748
CPT2 -7119
SLC25A20 -6613
THRSP -6569
MID1IP1 -5919
RXRA -5505
PPARD -3230
PRKAG2 -159
ACACA 621
CPT1A 2045

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKAA2 -8749
CPT1B -8667
ACACB -8428
SLC22A5 -8199
PRKAB2 -7748
CPT2 -7119
SLC25A20 -6613
THRSP -6569
MID1IP1 -5919
RXRA -5505
PPARD -3230
PRKAG2 -159
ACACA 621
CPT1A 2045


Striated Muscle Contraction

Striated Muscle Contraction
1250
set Striated Muscle Contraction
setSize 34
pANOVA 9.96e-09
s.dist -0.568
p.adjustANOVA 3.17e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEB -8853
ACTN3 -8849
TNNT3 -8818
MYH6 -8802
TPM2 -8734
TNNI3 -8680
DMD -8674
TPM3 -8600
TPM1 -8576
TNNT2 -8490
TMOD1 -8465
MYH3 -8444
TNNC2 -8419
TMOD4 -7585
MYL2 -6617
MYBPC1 -6314
ACTA1 -6006
MYL1 -5936
TNNI1 -5718
MYBPC2 -5592

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEB -8853
ACTN3 -8849
TNNT3 -8818
MYH6 -8802
TPM2 -8734
TNNI3 -8680
DMD -8674
TPM3 -8600
TPM1 -8576
TNNT2 -8490
TMOD1 -8465
MYH3 -8444
TNNC2 -8419
TMOD4 -7585
MYL2 -6617
MYBPC1 -6314
ACTA1 -6006
MYL1 -5936
TNNI1 -5718
MYBPC2 -5592
TCAP -5510
TNNC1 -5438
TNNT1 -4978
DES -4703
ACTN2 -4662
TNNI2 -4356
TTN -4017
MYL3 -3771
ACTC1 -3322
MYBPC3 -1221
TMOD2 1364
TMOD3 5040
TPM4 5621
VIM 7024


ADP signalling through P2Y purinoceptor 12

ADP signalling through P2Y purinoceptor 12
7
set ADP signalling through P2Y purinoceptor 12
setSize 15
pANOVA 0.000192
s.dist 0.556
p.adjustANOVA 0.00185



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNB2 7408
GNAI3 7072
GNB1 6899
GNAI2 6752
GNB4 5982
GNB3 5454
GNG2 4869
GNG12 4837
GNGT2 3403
GNG10 3315
GNB5 2833
GNAI1 2751
GNG7 1283
GNG11 -492
GNG5 -2086

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNB2 7408
GNAI3 7072
GNB1 6899
GNAI2 6752
GNB4 5982
GNB3 5454
GNG2 4869
GNG12 4837
GNGT2 3403
GNG10 3315
GNB5 2833
GNAI1 2751
GNG7 1283
GNG11 -492
GNG5 -2086


Mitochondrial calcium ion transport

Mitochondrial calcium ion transport
700
set Mitochondrial calcium ion transport
setSize 22
pANOVA 7.15e-06
s.dist -0.553
p.adjustANOVA 0.000132



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC8A3 -8556
AKAP1 -8441
MCU -7947
VDAC3 -7897
AFG3L2 -7791
VDAC1 -7655
MICU1 -7223
PMPCA -7085
MICU3 -6845
SMDT1 -6618
VDAC2 -6544
STOML2 -6412
PHB2 -6378
MICU2 -6072
LETM1 -5748
YME1L1 -4485
PHB -3728
PARL -3139
SPG7 -3047
PMPCB -2615

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC8A3 -8556
AKAP1 -8441
MCU -7947
VDAC3 -7897
AFG3L2 -7791
VDAC1 -7655
MICU1 -7223
PMPCA -7085
MICU3 -6845
SMDT1 -6618
VDAC2 -6544
STOML2 -6412
PHB2 -6378
MICU2 -6072
LETM1 -5748
YME1L1 -4485
PHB -3728
PARL -3139
SPG7 -3047
PMPCB -2615
SLC8B1 5229
MCUB 5762


Regulation of pyruvate dehydrogenase (PDH) complex

Regulation of pyruvate dehydrogenase (PDH) complex
1061
set Regulation of pyruvate dehydrogenase (PDH) complex
setSize 15
pANOVA 0.000282
s.dist -0.542
p.adjustANOVA 0.00246



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDK4 -8572
PDK2 -8545
PDHX -8293
DLD -8063
DLAT -7956
PDHA1 -7882
PDHB -7423
PDP1 -6745
GSTZ1 -5852
RXRA -5505
PDP2 -4721
PPARD -3230
PDPR -2878
PDK1 3632
PDK3 6195

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDK4 -8572
PDK2 -8545
PDHX -8293
DLD -8063
DLAT -7956
PDHA1 -7882
PDHB -7423
PDP1 -6745
GSTZ1 -5852
RXRA -5505
PDP2 -4721
PPARD -3230
PDPR -2878
PDK1 3632
PDK3 6195


Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis
190
set Chondroitin sulfate biosynthesis
setSize 15
pANOVA 0.000293
s.dist 0.54
p.adjustANOVA 0.0025



Top enriched genes

Top 20 genes
GeneID Gene Rank
CSPG4 7275
CHPF2 6942
CHST11 6677
CSGALNACT2 6609
CSGALNACT1 6350
CHSY1 6277
CHPF 5937
BGN 4106
VCAN 3538
CHST12 2701
CHSY3 1872
CHST3 1339
CHST15 1084
DCN -862
CHST7 -1549

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CSPG4 7275
CHPF2 6942
CHST11 6677
CSGALNACT2 6609
CSGALNACT1 6350
CHSY1 6277
CHPF 5937
BGN 4106
VCAN 3538
CHST12 2701
CHSY3 1872
CHST3 1339
CHST15 1084
DCN -862
CHST7 -1549


Scavenging by Class A Receptors

Scavenging by Class A Receptors
1132
set Scavenging by Class A Receptors
setSize 16
pANOVA 0.000186
s.dist 0.54
p.adjustANOVA 0.00181



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90B1 7109
COL1A1 6748
COL3A1 6479
COLEC12 5795
COL1A2 5750
CALR 5600
COL4A2 5466
MARCO 5195
FTL 5098
MSR1 4879
FTH1 4519
SCARA5 4131
COL4A1 3759
APOE 1717
APOB -1722
MASP1 -8392

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90B1 7109
COL1A1 6748
COL3A1 6479
COLEC12 5795
COL1A2 5750
CALR 5600
COL4A2 5466
MARCO 5195
FTL 5098
MSR1 4879
FTH1 4519
SCARA5 4131
COL4A1 3759
APOE 1717
APOB -1722
MASP1 -8392


Mitochondrial translation

Mitochondrial translation
704
set Mitochondrial translation
setSize 94
pANOVA 7.05e-19
s.dist -0.529
p.adjustANOVA 1.47e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123
MRPL11 -7106
ERAL1 -7079
MRPL19 -7055
MRPS18A -6993
TUFM -6982
MRPL15 -6948
MRPL12 -6915
MRPS33 -6870
GFM1 -6830
MRPL30 -6793
MRPL34 -6770
GFM2 -6749
MRPS5 -6673
MRPS16 -6671
TSFM -6621
MRPL41 -6582
MRPL38 -6497
MRPL2 -6480
MRPL16 -6371
MRPL40 -6360
MRPL1 -6274
MRPL35 -6257
MRRF -6243
MRPL4 -6156
MRPL24 -6039
MRPL39 -5948
MTFMT -5806
MRPL20 -5782
AURKAIP1 -5763
MRPS17 -5651
MRPS22 -5637
MRPL14 -5631
MRPL53 -5589
MRPL45 -5555
MRPL57 -5352
MRPS26 -5222
MTIF3 -5085
MRPS36 -5020
DAP3 -4870
MRPS11 -4799
MRPL21 -4643
MRPS31 -4581
MRPL9 -4573
MRPL43 -4494
MRPL32 -4446
MRPL50 -4272
MRPL47 -4182
MTIF2 -4088
MRPL49 -4041
MRPS12 -3973
MTRF1L -3526
MRPS34 -3480
MRPL48 -3284
MRPL36 -2530
MRPL51 -2435
MRPL13 -2400
MRPS18C -2333
MRPL55 -2318
MRPL3 -2211
MRPL28 -2074
MRPL18 -1941
MRPL42 -1900
MRPL23 -1805
MRPL52 -1629
MRPL22 -1620
MRPL27 -1197
GADD45GIP1 -1099
MRPS6 -770
CHCHD1 -710
MRPS14 -538
MRPS23 -142
MRPL54 2764
MRPS21 6964
MRPL17 7526


Mitochondrial translation elongation

Mitochondrial translation elongation
705
set Mitochondrial translation elongation
setSize 88
pANOVA 1.33e-17
s.dist -0.527
p.adjustANOVA 2.42e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123
MRPL11 -7106
ERAL1 -7079
MRPL19 -7055
MRPS18A -6993
TUFM -6982
MRPL15 -6948
MRPL12 -6915
MRPS33 -6870
GFM1 -6830
MRPL30 -6793
MRPL34 -6770
MRPS5 -6673
MRPS16 -6671
TSFM -6621
MRPL41 -6582
MRPL38 -6497
MRPL2 -6480
MRPL16 -6371
MRPL40 -6360
MRPL1 -6274
MRPL35 -6257
MRPL4 -6156
MRPL24 -6039
MRPL39 -5948
MRPL20 -5782
AURKAIP1 -5763
MRPS17 -5651
MRPS22 -5637
MRPL14 -5631
MRPL53 -5589
MRPL45 -5555
MRPL57 -5352
MRPS26 -5222
MRPS36 -5020
DAP3 -4870
MRPS11 -4799
MRPL21 -4643
MRPS31 -4581
MRPL9 -4573
MRPL43 -4494
MRPL32 -4446
MRPL50 -4272
MRPL47 -4182
MRPL49 -4041
MRPS12 -3973
MRPS34 -3480
MRPL48 -3284
MRPL36 -2530
MRPL51 -2435
MRPL13 -2400
MRPS18C -2333
MRPL55 -2318
MRPL3 -2211
MRPL28 -2074
MRPL18 -1941
MRPL42 -1900
MRPL23 -1805
MRPL52 -1629
MRPL22 -1620
MRPL27 -1197
GADD45GIP1 -1099
MRPS6 -770
CHCHD1 -710
MRPS14 -538
MRPS23 -142
MRPL54 2764
MRPS21 6964
MRPL17 7526


Trafficking and processing of endosomal TLR

Trafficking and processing of endosomal TLR
1342
set Trafficking and processing of endosomal TLR
setSize 12
pANOVA 0.0016
s.dist 0.526
p.adjustANOVA 0.0102



Top enriched genes

Top 20 genes
GeneID Gene Rank
HSP90B1 7109
CTSK 6644
CNPY3 6211
UNC93B1 6201
CTSB 5437
CTSS 4744
TLR8 4394
TLR7 4288
CTSL 3571
LGMN 3162
TLR3 -117
TLR9 -6376

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HSP90B1 7109
CTSK 6644
CNPY3 6211
UNC93B1 6201
CTSB 5437
CTSS 4744
TLR8 4394
TLR7 4288
CTSL 3571
LGMN 3162
TLR3 -117
TLR9 -6376


G beta:gamma signalling through BTK

G beta:gamma signalling through BTK
432
set G beta:gamma signalling through BTK
setSize 13
pANOVA 0.00106
s.dist 0.524
p.adjustANOVA 0.00712



Top enriched genes

Top 20 genes
GeneID Gene Rank
GNB2 7408
GNB1 6899
GNB4 5982
GNB3 5454
BTK 5127
GNG2 4869
GNG12 4837
GNGT2 3403
GNG10 3315
GNB5 2833
GNG7 1283
GNG11 -492
GNG5 -2086

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GNB2 7408
GNB1 6899
GNB4 5982
GNB3 5454
BTK 5127
GNG2 4869
GNG12 4837
GNGT2 3403
GNG10 3315
GNB5 2833
GNG7 1283
GNG11 -492
GNG5 -2086


Processing of SMDT1

Processing of SMDT1
897
set Processing of SMDT1
setSize 15
pANOVA 0.000445
s.dist -0.524
p.adjustANOVA 0.00354



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCU -7947
AFG3L2 -7791
MICU1 -7223
PMPCA -7085
MICU3 -6845
SMDT1 -6618
STOML2 -6412
PHB2 -6378
MICU2 -6072
YME1L1 -4485
PHB -3728
PARL -3139
SPG7 -3047
PMPCB -2615
MCUB 5762

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCU -7947
AFG3L2 -7791
MICU1 -7223
PMPCA -7085
MICU3 -6845
SMDT1 -6618
STOML2 -6412
PHB2 -6378
MICU2 -6072
YME1L1 -4485
PHB -3728
PARL -3139
SPG7 -3047
PMPCB -2615
MCUB 5762


Signaling by Leptin

Signaling by Leptin
1197
set Signaling by Leptin
setSize 11
pANOVA 0.00264
s.dist -0.524
p.adjustANOVA 0.0153



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRS2 -8285
IRS1 -8236
STAT5B -8185
LEP -7651
STAT3 -7121
LEPR -5707
JAK2 -5334
PTPN11 -5139
SH2B1 -4834
STAT5A 2825
SOCS3 3681

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRS2 -8285
IRS1 -8236
STAT5B -8185
LEP -7651
STAT3 -7121
LEPR -5707
JAK2 -5334
PTPN11 -5139
SH2B1 -4834
STAT5A 2825
SOCS3 3681


Cristae formation

Cristae formation
229
set Cristae formation
setSize 29
pANOVA 1.08e-06
s.dist -0.523
p.adjustANOVA 2.28e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
CHCHD3 -8054
APOO -7898
ATP5F1A -7847
ATP5MC1 -7806
ATP5F1B -7735
ATP5F1D -7668
SAMM50 -7542
ATP5MC2 -7465
TMEM11 -7445
APOOL -7410
ATP5PF -7328
ATP5PO -7324
ATP5MC3 -7189
IMMT -6768
DNAJC11 -6679
DMAC2L -6580
ATP5PB -6254
ATP5F1C -6157
HSPA9 -5953
MTX2 -5487

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CHCHD3 -8054
APOO -7898
ATP5F1A -7847
ATP5MC1 -7806
ATP5F1B -7735
ATP5F1D -7668
SAMM50 -7542
ATP5MC2 -7465
TMEM11 -7445
APOOL -7410
ATP5PF -7328
ATP5PO -7324
ATP5MC3 -7189
IMMT -6768
DNAJC11 -6679
DMAC2L -6580
ATP5PB -6254
ATP5F1C -6157
HSPA9 -5953
MTX2 -5487
ATP5PD -5326
ATP5MG -5155
ATP5MF -3044
ATP5ME -2219
MICOS13 -994
ATP5F1E 2069
MICOS10 3212
CHCHD6 5175
MTX1 6766


Mitochondrial translation termination

Mitochondrial translation termination
707
set Mitochondrial translation termination
setSize 88
pANOVA 2.82e-17
s.dist -0.521
p.adjustANOVA 4.59e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123
MRPL11 -7106
ERAL1 -7079
MRPL19 -7055
MRPS18A -6993
MRPL15 -6948
MRPL12 -6915
MRPS33 -6870
MRPL30 -6793
MRPL34 -6770
GFM2 -6749
MRPS5 -6673
MRPS16 -6671
MRPL41 -6582
MRPL38 -6497
MRPL2 -6480
MRPL16 -6371
MRPL40 -6360
MRPL1 -6274
MRPL35 -6257
MRRF -6243
MRPL4 -6156
MRPL24 -6039
MRPL39 -5948
MRPL20 -5782
AURKAIP1 -5763
MRPS17 -5651
MRPS22 -5637
MRPL14 -5631
MRPL53 -5589
MRPL45 -5555
MRPL57 -5352
MRPS26 -5222
MRPS36 -5020
DAP3 -4870
MRPS11 -4799
MRPL21 -4643
MRPS31 -4581
MRPL9 -4573
MRPL43 -4494
MRPL32 -4446
MRPL50 -4272
MRPL47 -4182
MRPL49 -4041
MRPS12 -3973
MTRF1L -3526
MRPS34 -3480
MRPL48 -3284
MRPL36 -2530
MRPL51 -2435
MRPL13 -2400
MRPS18C -2333
MRPL55 -2318
MRPL3 -2211
MRPL28 -2074
MRPL18 -1941
MRPL42 -1900
MRPL23 -1805
MRPL52 -1629
MRPL22 -1620
MRPL27 -1197
GADD45GIP1 -1099
MRPS6 -770
CHCHD1 -710
MRPS14 -538
MRPS23 -142
MRPL54 2764
MRPS21 6964
MRPL17 7526


Mitochondrial translation initiation

Mitochondrial translation initiation
706
set Mitochondrial translation initiation
setSize 88
pANOVA 3.79e-17
s.dist -0.519
p.adjustANOVA 5.55e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPS25 -8036
MRPS9 -7880
MRPL10 -7876
MRPL33 -7865
MRPS30 -7840
PTCD3 -7718
MRPS28 -7580
MRPL46 -7576
MRPS27 -7543
MRPS7 -7510
MRPL58 -7489
MRPS18B -7381
MRPL44 -7376
MRPS24 -7213
MRPS10 -7211
MRPS15 -7166
MRPL37 -7149
MRPS2 -7138
MRPS35 -7128
OXA1L -7123
MRPL11 -7106
ERAL1 -7079
MRPL19 -7055
MRPS18A -6993
MRPL15 -6948
MRPL12 -6915
MRPS33 -6870
MRPL30 -6793
MRPL34 -6770
MRPS5 -6673
MRPS16 -6671
MRPL41 -6582
MRPL38 -6497
MRPL2 -6480
MRPL16 -6371
MRPL40 -6360
MRPL1 -6274
MRPL35 -6257
MRPL4 -6156
MRPL24 -6039
MRPL39 -5948
MTFMT -5806
MRPL20 -5782
AURKAIP1 -5763
MRPS17 -5651
MRPS22 -5637
MRPL14 -5631
MRPL53 -5589
MRPL45 -5555
MRPL57 -5352
MRPS26 -5222
MTIF3 -5085
MRPS36 -5020
DAP3 -4870
MRPS11 -4799
MRPL21 -4643
MRPS31 -4581
MRPL9 -4573
MRPL43 -4494
MRPL32 -4446
MRPL50 -4272
MRPL47 -4182
MTIF2 -4088
MRPL49 -4041
MRPS12 -3973
MRPS34 -3480
MRPL48 -3284
MRPL36 -2530
MRPL51 -2435
MRPL13 -2400
MRPS18C -2333
MRPL55 -2318
MRPL3 -2211
MRPL28 -2074
MRPL18 -1941
MRPL42 -1900
MRPL23 -1805
MRPL52 -1629
MRPL22 -1620
MRPL27 -1197
GADD45GIP1 -1099
MRPS6 -770
CHCHD1 -710
MRPS14 -538
MRPS23 -142
MRPL54 2764
MRPS21 6964
MRPL17 7526


Beta-oxidation of very long chain fatty acids

Beta-oxidation of very long chain fatty acids
114
set Beta-oxidation of very long chain fatty acids
setSize 10
pANOVA 0.00449
s.dist -0.519
p.adjustANOVA 0.0234



Top enriched genes

Top 20 genes
GeneID Gene Rank
MLYCD -8233
ECI2 -7975
ACOX1 -7335
ACOT8 -7082
DECR2 -6555
ACAA1 -5166
EHHADH -4873
ABCD1 -4081
HSD17B4 -3953
ACOT4 6554

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MLYCD -8233
ECI2 -7975
ACOX1 -7335
ACOT8 -7082
DECR2 -6555
ACAA1 -5166
EHHADH -4873
ABCD1 -4081
HSD17B4 -3953
ACOT4 6554


Metal ion SLC transporters

Metal ion SLC transporters
689
set Metal ion SLC transporters
setSize 18
pANOVA 0.00019
s.dist 0.508
p.adjustANOVA 0.00184



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC41A2 7384
SLC31A1 7163
SLC39A6 6912
SLC39A7 6824
SLC39A14 6450
SLC39A1 6124
SLC30A1 5760
SLC39A3 5503
SLC11A1 5433
SLC30A5 5292
SLC11A2 5057
SLC39A10 4451
SLC39A8 2510
HEPH 2209
SLC39A4 1180
CP 795
SLC40A1 -5316
SLC41A1 -8543

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC41A2 7384
SLC31A1 7163
SLC39A6 6912
SLC39A7 6824
SLC39A14 6450
SLC39A1 6124
SLC30A1 5760
SLC39A3 5503
SLC11A1 5433
SLC30A5 5292
SLC11A2 5057
SLC39A10 4451
SLC39A8 2510
HEPH 2209
SLC39A4 1180
CP 795
SLC40A1 -5316
SLC41A1 -8543


RHO GTPases activate IQGAPs

RHO GTPases activate IQGAPs
934
set RHO GTPases activate IQGAPs
setSize 23
pANOVA 3.51e-05
s.dist 0.498
p.adjustANOVA 0.000504



Top enriched genes

Top 20 genes
GeneID Gene Rank
IQGAP3 7547
TUBA1B 7401
IQGAP1 7390
CTNNA1 7302
TUBB6 7214
TUBA1C 7139
TUBB3 7114
TUBB2A 7018
ACTG1 6928
ACTB 6717
RAC1 6642
TUBA1A 6086
TUBB4B 6072
IQGAP2 4487
CALM1 4486
CTNNB1 4411
CDC42 4128
MEN1 3710
TUBB2B -2451
TUBAL3 -3328

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IQGAP3 7547
TUBA1B 7401
IQGAP1 7390
CTNNA1 7302
TUBB6 7214
TUBA1C 7139
TUBB3 7114
TUBB2A 7018
ACTG1 6928
ACTB 6717
RAC1 6642
TUBA1A 6086
TUBB4B 6072
IQGAP2 4487
CALM1 4486
CTNNB1 4411
CDC42 4128
MEN1 3710
TUBB2B -2451
TUBAL3 -3328
CLIP1 -7231
TUBA8 -8669
TUBA4A -8705


Keratan sulfate degradation

Keratan sulfate degradation
616
set Keratan sulfate degradation
setSize 13
pANOVA 0.00191
s.dist 0.497
p.adjustANOVA 0.0117



Top enriched genes

Top 20 genes
GeneID Gene Rank
HEXB 6858
OGN 6112
GALNS 5027
GLB1 4895
HEXA 4675
LUM 4581
GLB1L 4488
GNS 3883
FMOD 3320
OMD 2347
PRELP 1658
ACAN 750
KERA -2671

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HEXB 6858
OGN 6112
GALNS 5027
GLB1 4895
HEXA 4675
LUM 4581
GLB1L 4488
GNS 3883
FMOD 3320
OMD 2347
PRELP 1658
ACAN 750
KERA -2671


Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine
289
set Degradation of cysteine and homocysteine
setSize 14
pANOVA 0.00142
s.dist -0.492
p.adjustANOVA 0.00911



Top enriched genes

Top 20 genes
GeneID Gene Rank
GADL1 -8638
GOT2 -8442
SUOX -8257
TST -7716
TXN2 -7454
FMO1 -7196
MPST -6929
TSTD1 -6469
SLC25A10 -5569
CTH -4422
CSAD -424
ADO -326
CDO1 2699
ETHE1 4042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GADL1 -8638
GOT2 -8442
SUOX -8257
TST -7716
TXN2 -7454
FMO1 -7196
MPST -6929
TSTD1 -6469
SLC25A10 -5569
CTH -4422
CSAD -424
ADO -326
CDO1 2699
ETHE1 4042


Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation
1016
set Regulation of FOXO transcriptional activity by acetylation
setSize 10
pANOVA 0.00703
s.dist -0.492
p.adjustANOVA 0.0329



Top enriched genes

Top 20 genes
GeneID Gene Rank
FOXO4 -8412
TXNIP -8255
KAT2B -8108
FOXO3 -7487
CREBBP -6715
SIRT3 -6467
SIRT1 -6191
EP300 -5002
FOXO1 2454
TXN 7687

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXO4 -8412
TXNIP -8255
KAT2B -8108
FOXO3 -7487
CREBBP -6715
SIRT3 -6467
SIRT1 -6191
EP300 -5002
FOXO1 2454
TXN 7687


FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes
393
set FOXO-mediated transcription of cell death genes
setSize 15
pANOVA 0.00111
s.dist -0.486
p.adjustANOVA 0.00732



Top enriched genes

Top 20 genes
GeneID Gene Rank
BCL6 -8537
FOXO4 -8412
CITED2 -8110
PINK1 -7768
FOXO3 -7487
STK11 -7344
NFYC -7311
NFYB -7126
CREBBP -6715
BCL2L11 -6517
EP300 -5002
DDIT3 -1554
FOXO1 2454
NFYA 3379
BBC3 7070

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BCL6 -8537
FOXO4 -8412
CITED2 -8110
PINK1 -7768
FOXO3 -7487
STK11 -7344
NFYC -7311
NFYB -7126
CREBBP -6715
BCL2L11 -6517
EP300 -5002
DDIT3 -1554
FOXO1 2454
NFYA 3379
BBC3 7070


Chondroitin sulfate/dermatan sulfate metabolism

Chondroitin sulfate/dermatan sulfate metabolism
191
set Chondroitin sulfate/dermatan sulfate metabolism
setSize 43
pANOVA 3.86e-08
s.dist 0.484
p.adjustANOVA 1.11e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDS 7532
B3GALT6 7490
SDC2 7344
CSPG4 7275
CHPF2 6942
HEXB 6858
B3GAT3 6762
CHST11 6677
GPC6 6623
CSGALNACT2 6609
DSEL 6555
CSGALNACT1 6350
CHSY1 6277
ARSB 6208
XYLT2 6000
CHPF 5937
UST 5799
DSE 5732
CHST14 4907
HEXA 4675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDS 7532
B3GALT6 7490
SDC2 7344
CSPG4 7275
CHPF2 6942
HEXB 6858
B3GAT3 6762
CHST11 6677
GPC6 6623
CSGALNACT2 6609
DSEL 6555
CSGALNACT1 6350
CHSY1 6277
ARSB 6208
XYLT2 6000
CHPF 5937
UST 5799
DSE 5732
CHST14 4907
HEXA 4675
XYLT1 4419
BGN 4106
IDUA 3773
HYAL3 3711
VCAN 3538
SDC1 3054
CHST12 2701
HYAL1 2590
B4GALT7 2500
CHSY3 1872
CHST3 1339
GPC2 1309
CHST15 1084
SDC3 846
AGRN 831
HSPG2 685
SDC4 186
DCN -862
GPC3 -1005
CHST7 -1549
B3GAT2 -2271
GPC4 -6934
GPC1 -7422


TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
1289
set TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
setSize 13
pANOVA 0.00284
s.dist 0.478
p.adjustANOVA 0.0163



Top enriched genes

Top 20 genes
GeneID Gene Rank
TNFSF11 7299
TNFRSF11A 6758
TNFRSF12A 6621
TRAF2 4569
LTBR 4474
TNFSF12 4322
TRAF3 4222
BIRC3 3827
BIRC2 3084
TNFSF13B 2589
MAP3K14 1451
CD40 -511
LTB -4846

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TNFSF11 7299
TNFRSF11A 6758
TNFRSF12A 6621
TRAF2 4569
LTBR 4474
TNFSF12 4322
TRAF3 4222
BIRC3 3827
BIRC2 3084
TNFSF13B 2589
MAP3K14 1451
CD40 -511
LTB -4846


Leading Strand Synthesis

Leading Strand Synthesis
630
set Leading Strand Synthesis
setSize 14
pANOVA 0.00201
s.dist 0.477
p.adjustANOVA 0.0121



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCNA 7279
POLD3 7206
RFC4 6944
POLD1 6098
RFC2 5854
POLD4 5805
POLA2 4978
RFC1 3798
PRIM2 3556
PRIM1 2908
RFC5 2656
RFC3 -1530
POLD2 -3447
POLA1 -5022

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCNA 7279
POLD3 7206
RFC4 6944
POLD1 6098
RFC2 5854
POLD4 5805
POLA2 4978
RFC1 3798
PRIM2 3556
PRIM1 2908
RFC5 2656
RFC3 -1530
POLD2 -3447
POLA1 -5022


Polymerase switching

Polymerase switching
874
set Polymerase switching
setSize 14
pANOVA 0.00201
s.dist 0.477
p.adjustANOVA 0.0121



Top enriched genes

Top 20 genes
GeneID Gene Rank
PCNA 7279
POLD3 7206
RFC4 6944
POLD1 6098
RFC2 5854
POLD4 5805
POLA2 4978
RFC1 3798
PRIM2 3556
PRIM1 2908
RFC5 2656
RFC3 -1530
POLD2 -3447
POLA1 -5022

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PCNA 7279
POLD3 7206
RFC4 6944
POLD1 6098
RFC2 5854
POLD4 5805
POLA2 4978
RFC1 3798
PRIM2 3556
PRIM1 2908
RFC5 2656
RFC3 -1530
POLD2 -3447
POLA1 -5022


Signal regulatory protein family interactions

Signal regulatory protein family interactions
1153
set Signal regulatory protein family interactions
setSize 11
pANOVA 0.00635
s.dist 0.475
p.adjustANOVA 0.0312



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD47 7327
SRC 6995
SIRPA 5353
TYROBP 5273
PTPN6 5101
GRB2 3844
PTK2B 3563
SIRPB1 2824
SKAP2 2024
PTK2 -304
PTPN11 -5139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD47 7327
SRC 6995
SIRPA 5353
TYROBP 5273
PTPN6 5101
GRB2 3844
PTK2B 3563
SIRPB1 2824
SKAP2 2024
PTK2 -304
PTPN11 -5139


Mitochondrial Fatty Acid Beta-Oxidation

Mitochondrial Fatty Acid Beta-Oxidation
698
set Mitochondrial Fatty Acid Beta-Oxidation
setSize 34
pANOVA 1.7e-06
s.dist -0.474
p.adjustANOVA 3.36e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
HADH -8636
ACADM -8447
ACADL -8338
ACOT2 -8312
ACADS -8292
HADHB -8192
ECI1 -7682
PCCB -7554
ECHS1 -7513
NDUFAB1 -7443
THEM4 -7391
ACADVL -7312
MECR -7258
ACAA2 -7112
HADHA -6853
DECR1 -6542
ACSF2 -6468
ACOT1 -6339
PCCA -6101
ACAD10 -5549

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HADH -8636
ACADM -8447
ACADL -8338
ACOT2 -8312
ACADS -8292
HADHB -8192
ECI1 -7682
PCCB -7554
ECHS1 -7513
NDUFAB1 -7443
THEM4 -7391
ACADVL -7312
MECR -7258
ACAA2 -7112
HADHA -6853
DECR1 -6542
ACSF2 -6468
ACOT1 -6339
PCCA -6101
ACAD10 -5549
MMUT -5492
MCAT -5123
ACOT11 -4673
MCEE -3796
ACOT13 -3296
MMAA -3068
ACSM3 -1568
ACBD7 -9
ACBD6 413
DBI 606
PCTP 3342
ACAD11 4530
ACOT9 5445
ACOT7 7205


Prolactin receptor signaling

Prolactin receptor signaling
901
set Prolactin receptor signaling
setSize 10
pANOVA 0.0105
s.dist -0.467
p.adjustANOVA 0.0455



Top enriched genes

Top 20 genes
GeneID Gene Rank
GHR -8664
STAT5B -8185
SKP1 -6792
BTRC -5340
JAK2 -5334
PTPN11 -5139
CUL1 -4872
SH2B1 -4834
RBX1 1924
STAT5A 2825

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GHR -8664
STAT5B -8185
SKP1 -6792
BTRC -5340
JAK2 -5334
PTPN11 -5139
CUL1 -4872
SH2B1 -4834
RBX1 1924
STAT5A 2825


FCGR activation

FCGR activation
382
set FCGR activation
setSize 11
pANOVA 0.00744
s.dist 0.466
p.adjustANOVA 0.0343



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC 6995
FGR 5461
SYK 5407
HCK 4597
LYN 4564
FCGR1A 3514
FYN 2954
FCGR2A 2637
FCGR3A 2212
YES1 1651
CD3G -3961

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC 6995
FGR 5461
SYK 5407
HCK 4597
LYN 4564
FCGR1A 3514
FYN 2954
FCGR2A 2637
FCGR3A 2212
YES1 1651
CD3G -3961


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               cachem_1.0.8            zlibbioc_1.48.0        
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] yaml_2.3.8              rstudioapi_0.15.0       abind_1.4-5            
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report