date generated: 2024-03-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA 1.4758490
7SK -0.5096905
A1BG 2.8137638
A1BG.AS1 1.2793604
A2M -4.1729641
A2M.AS1 -0.8450553

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 16566
duplicated_genes_present 0
num_profile_genes_in_sets 8314
num_profile_genes_not_in_sets 8252

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1149
num_genesets_included 1463

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Expression and translocation of olfactory receptors 21 1.14e-09 -0.767 5.58e-08
Zinc transporters 10 8.19e-05 0.719 1.08e-03
Olfactory Signaling Pathway 25 2.19e-09 -0.691 1.04e-07
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.57e-04 -0.690 1.75e-03
Trafficking and processing of endosomal TLR 12 1.18e-04 0.642 1.47e-03
FCGR activation 10 4.77e-04 0.638 4.59e-03
Keratan sulfate degradation 13 1.00e-04 0.623 1.29e-03
Citric acid cycle (TCA cycle) 22 1.60e-06 -0.591 4.12e-05
Mucopolysaccharidoses 11 8.75e-04 0.579 7.36e-03
Phase 0 - rapid depolarisation 27 5.86e-07 -0.555 1.78e-05
Regulation of CDH11 gene transcription 10 2.37e-03 0.555 1.64e-02
Metal ion SLC transporters 18 6.51e-05 0.544 8.99e-04
Retrograde neurotrophin signalling 13 7.30e-04 0.541 6.36e-03
Nitric oxide stimulates guanylate cyclase 17 1.33e-04 -0.535 1.56e-03
Dissolution of Fibrin Clot 10 3.48e-03 0.534 2.24e-02
Glyoxylate metabolism and glycine degradation 24 6.82e-06 -0.530 1.41e-04
CS/DS degradation 10 4.23e-03 0.522 2.60e-02
Complex I biogenesis 51 1.77e-10 -0.516 9.57e-09
Striated Muscle Contraction 35 1.61e-07 -0.512 5.62e-06
The activation of arylsulfatases 10 5.44e-03 0.508 3.17e-02
SARS-CoV-1 modulates host translation machinery 36 2.82e-07 0.495 9.17e-06
Diseases associated with N-glycosylation of proteins 20 1.30e-04 0.494 1.56e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 6.81e-03 -0.494 3.80e-02
Formation of ATP by chemiosmotic coupling 16 6.48e-04 -0.492 5.85e-03
cGMP effects 14 1.46e-03 -0.491 1.11e-02
RUNX3 regulates p14-ARF 10 7.81e-03 0.486 4.30e-02
Respiratory electron transport 93 6.23e-16 -0.485 1.52e-13
WNT5A-dependent internalization of FZD4 14 1.72e-03 0.484 1.30e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 1.84e-18 -0.477 5.39e-16
Peptide chain elongation 88 3.02e-14 0.468 4.92e-12
Viral mRNA Translation 88 1.52e-13 0.455 1.71e-11
Formation of annular gap junctions 11 9.60e-03 0.451 5.08e-02
Syndecan interactions 26 8.22e-05 0.446 1.08e-03
Mitochondrial translation elongation 88 5.00e-13 -0.446 4.57e-11
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 5.46e-03 0.445 3.17e-02
Mitochondrial translation 94 9.69e-14 -0.444 1.29e-11
Eukaryotic Translation Elongation 93 1.38e-13 0.444 1.69e-11
Selenocysteine synthesis 92 1.90e-13 0.444 1.98e-11
Chondroitin sulfate biosynthesis 16 2.18e-03 0.442 1.55e-02
Chondroitin sulfate/dermatan sulfate metabolism 42 7.19e-07 0.442 2.10e-05
RHO GTPases Activate NADPH Oxidases 21 4.56e-04 0.442 4.45e-03
Mitochondrial translation initiation 88 8.62e-13 -0.441 7.01e-11
SRP-dependent cotranslational protein targeting to membrane 111 1.30e-15 0.439 2.72e-13
Mitochondrial translation termination 88 1.47e-12 -0.436 1.13e-10
The citric acid (TCA) cycle and respiratory electron transport 160 2.77e-21 -0.434 4.05e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 3.63e-13 0.434 3.54e-11
Eukaryotic Translation Termination 92 6.46e-13 0.434 5.56e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 6.81e-14 0.433 9.96e-12
Gap junction degradation 12 1.01e-02 0.429 5.23e-02
Signal regulatory protein family interactions 11 1.43e-02 0.427 6.86e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Expression and translocation of olfactory receptors 21 1.14e-09 -7.67e-01 5.58e-08
Zinc transporters 10 8.19e-05 7.19e-01 1.08e-03
Olfactory Signaling Pathway 25 2.19e-09 -6.91e-01 1.04e-07
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 1.57e-04 -6.90e-01 1.75e-03
Trafficking and processing of endosomal TLR 12 1.18e-04 6.42e-01 1.47e-03
FCGR activation 10 4.77e-04 6.38e-01 4.59e-03
Keratan sulfate degradation 13 1.00e-04 6.23e-01 1.29e-03
Citric acid cycle (TCA cycle) 22 1.60e-06 -5.91e-01 4.12e-05
Mucopolysaccharidoses 11 8.75e-04 5.79e-01 7.36e-03
Phase 0 - rapid depolarisation 27 5.86e-07 -5.55e-01 1.78e-05
Regulation of CDH11 gene transcription 10 2.37e-03 5.55e-01 1.64e-02
Metal ion SLC transporters 18 6.51e-05 5.44e-01 8.99e-04
Retrograde neurotrophin signalling 13 7.30e-04 5.41e-01 6.36e-03
Nitric oxide stimulates guanylate cyclase 17 1.33e-04 -5.35e-01 1.56e-03
Dissolution of Fibrin Clot 10 3.48e-03 5.34e-01 2.24e-02
Glyoxylate metabolism and glycine degradation 24 6.82e-06 -5.30e-01 1.41e-04
CS/DS degradation 10 4.23e-03 5.22e-01 2.60e-02
Complex I biogenesis 51 1.77e-10 -5.16e-01 9.57e-09
Striated Muscle Contraction 35 1.61e-07 -5.12e-01 5.62e-06
The activation of arylsulfatases 10 5.44e-03 5.08e-01 3.17e-02
SARS-CoV-1 modulates host translation machinery 36 2.82e-07 4.95e-01 9.17e-06
Diseases associated with N-glycosylation of proteins 20 1.30e-04 4.94e-01 1.56e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 6.81e-03 -4.94e-01 3.80e-02
Formation of ATP by chemiosmotic coupling 16 6.48e-04 -4.92e-01 5.85e-03
cGMP effects 14 1.46e-03 -4.91e-01 1.11e-02
RUNX3 regulates p14-ARF 10 7.81e-03 4.86e-01 4.30e-02
Respiratory electron transport 93 6.23e-16 -4.85e-01 1.52e-13
WNT5A-dependent internalization of FZD4 14 1.72e-03 4.84e-01 1.30e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 1.84e-18 -4.77e-01 5.39e-16
Peptide chain elongation 88 3.02e-14 4.68e-01 4.92e-12
Viral mRNA Translation 88 1.52e-13 4.55e-01 1.71e-11
Formation of annular gap junctions 11 9.60e-03 4.51e-01 5.08e-02
Syndecan interactions 26 8.22e-05 4.46e-01 1.08e-03
Mitochondrial translation elongation 88 5.00e-13 -4.46e-01 4.57e-11
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 5.46e-03 4.45e-01 3.17e-02
Mitochondrial translation 94 9.69e-14 -4.44e-01 1.29e-11
Eukaryotic Translation Elongation 93 1.38e-13 4.44e-01 1.69e-11
Selenocysteine synthesis 92 1.90e-13 4.44e-01 1.98e-11
Chondroitin sulfate biosynthesis 16 2.18e-03 4.42e-01 1.55e-02
Chondroitin sulfate/dermatan sulfate metabolism 42 7.19e-07 4.42e-01 2.10e-05
RHO GTPases Activate NADPH Oxidases 21 4.56e-04 4.42e-01 4.45e-03
Mitochondrial translation initiation 88 8.62e-13 -4.41e-01 7.01e-11
SRP-dependent cotranslational protein targeting to membrane 111 1.30e-15 4.39e-01 2.72e-13
Mitochondrial translation termination 88 1.47e-12 -4.36e-01 1.13e-10
The citric acid (TCA) cycle and respiratory electron transport 160 2.77e-21 -4.34e-01 4.05e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 3.63e-13 4.34e-01 3.54e-11
Eukaryotic Translation Termination 92 6.46e-13 4.34e-01 5.56e-11
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 6.81e-14 4.33e-01 9.96e-12
Gap junction degradation 12 1.01e-02 4.29e-01 5.23e-02
Signal regulatory protein family interactions 11 1.43e-02 4.27e-01 6.86e-02
Cristae formation 29 8.25e-05 -4.22e-01 1.08e-03
The NLRP3 inflammasome 16 3.85e-03 4.17e-01 2.43e-02
Glycogen synthesis 13 9.25e-03 -4.17e-01 4.99e-02
Cardiogenesis 19 1.76e-03 -4.15e-01 1.31e-02
ERBB2 Regulates Cell Motility 13 9.66e-03 -4.15e-01 5.08e-02
Folding of actin by CCT/TriC 10 2.50e-02 -4.09e-01 1.05e-01
ERBB2 Activates PTK6 Signaling 11 1.87e-02 -4.09e-01 8.33e-02
IRAK4 deficiency (TLR2/4) 15 6.44e-03 4.06e-01 3.62e-02
Diseases associated with glycosaminoglycan metabolism 37 1.98e-05 4.05e-01 3.41e-04
G beta:gamma signalling through BTK 12 1.55e-02 4.03e-01 7.34e-02
Assembly of the ORC complex at the origin of replication 15 6.98e-03 -4.02e-01 3.88e-02
MyD88 deficiency (TLR2/4) 14 9.93e-03 3.98e-01 5.17e-02
G beta:gamma signalling through PI3Kgamma 19 2.74e-03 3.97e-01 1.83e-02
Antimicrobial peptides 20 2.15e-03 3.96e-01 1.54e-02
Ion homeostasis 48 2.25e-06 -3.95e-01 5.17e-05
PI-3K cascade:FGFR4 13 1.46e-02 -3.91e-01 6.94e-02
Inflammasomes 21 2.32e-03 3.84e-01 1.62e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 17 6.19e-03 3.84e-01 3.51e-02
GPVI-mediated activation cascade 31 2.20e-04 3.83e-01 2.33e-03
Formation of a pool of free 40S subunits 100 4.09e-11 3.82e-01 2.72e-09
Regulation of ornithine decarboxylase (ODC) 48 5.89e-06 -3.78e-01 1.25e-04
HDMs demethylate histones 21 2.73e-03 3.78e-01 1.83e-02
Selenoamino acid metabolism 114 3.60e-12 3.77e-01 2.63e-10
The role of Nef in HIV-1 replication and disease pathogenesis 23 1.99e-03 3.72e-01 1.44e-02
FCGR3A-mediated phagocytosis 57 1.17e-06 3.72e-01 3.11e-05
Leishmania phagocytosis 57 1.17e-06 3.72e-01 3.11e-05
Parasite infection 57 1.17e-06 3.72e-01 3.11e-05
Interleukin-10 signaling 34 2.06e-04 3.68e-01 2.22e-03
Smooth Muscle Contraction 36 1.38e-04 -3.67e-01 1.60e-03
Interaction between L1 and Ankyrins 25 1.64e-03 -3.64e-01 1.24e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 83 1.01e-08 3.64e-01 3.99e-07
Prostacyclin signalling through prostacyclin receptor 13 2.32e-02 3.64e-01 9.86e-02
Mitochondrial calcium ion transport 22 3.30e-03 -3.62e-01 2.13e-02
Regulation of actin dynamics for phagocytic cup formation 59 1.67e-06 3.61e-01 4.15e-05
PI3K events in ERBB2 signaling 14 1.96e-02 -3.60e-01 8.55e-02
Muscle contraction 164 2.08e-15 -3.59e-01 3.81e-13
IRE1alpha activates chaperones 50 1.19e-05 3.58e-01 2.30e-04
Other interleukin signaling 20 5.62e-03 3.58e-01 3.25e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 1.72e-02 -3.55e-01 7.82e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 1.72e-02 -3.55e-01 7.82e-02
Diseases associated with glycosylation precursor biosynthesis 15 1.76e-02 3.54e-01 7.93e-02
XBP1(S) activates chaperone genes 48 2.22e-05 3.54e-01 3.69e-04
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 6.79e-11 3.54e-01 4.01e-09
Nonsense-Mediated Decay (NMD) 114 6.79e-11 3.54e-01 4.01e-09
Metabolism of cofactors 18 9.37e-03 -3.54e-01 5.02e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 2.81e-02 3.52e-01 1.14e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 51 1.66e-05 -3.49e-01 2.92e-04
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.26e-05 -3.47e-01 2.39e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 3.26e-05 -3.47e-01 5.24e-04
Regulation of Apoptosis 51 2.10e-05 -3.44e-01 3.57e-04
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.69e-10 3.44e-01 2.37e-08
Scavenging by Class A Receptors 16 1.74e-02 3.43e-01 7.91e-02
PKA activation 16 1.75e-02 -3.43e-01 7.92e-02
LDL clearance 17 1.45e-02 3.43e-01 6.93e-02
DAP12 interactions 32 8.30e-04 3.41e-01 7.06e-03
rRNA processing in the mitochondrion 10 6.19e-02 -3.41e-01 2.11e-01
Formation of apoptosome 11 5.04e-02 -3.41e-01 1.82e-01
Regulation of the apoptosome activity 11 5.04e-02 -3.41e-01 1.82e-01
Elastic fibre formation 41 1.69e-04 3.40e-01 1.86e-03
Class I peroxisomal membrane protein import 20 8.60e-03 -3.39e-01 4.66e-02
ADP signalling through P2Y purinoceptor 12 14 2.80e-02 3.39e-01 1.14e-01
Degradation of GLI2 by the proteasome 57 1.12e-05 -3.36e-01 2.20e-04
Triglyceride catabolism 16 2.04e-02 -3.35e-01 8.84e-02
Diseases associated with the TLR signaling cascade 27 2.77e-03 3.33e-01 1.83e-02
Diseases of Immune System 27 2.77e-03 3.33e-01 1.83e-02
Degradation of GLI1 by the proteasome 57 1.49e-05 -3.32e-01 2.69e-04
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 3.58e-05 -3.31e-01 5.61e-04
Calnexin/calreticulin cycle 26 3.49e-03 3.31e-01 2.24e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 7.00e-02 3.31e-01 2.33e-01
Vpu mediated degradation of CD4 50 5.27e-05 -3.31e-01 7.56e-04
Fcgamma receptor (FCGR) dependent phagocytosis 82 2.44e-07 3.30e-01 8.11e-06
Role of LAT2/NTAL/LAB on calcium mobilization 16 2.25e-02 3.29e-01 9.66e-02
Somitogenesis 50 5.94e-05 -3.28e-01 8.28e-04
GLI3 is processed to GLI3R by the proteasome 57 1.92e-05 -3.27e-01 3.34e-04
RAF activation 34 9.72e-04 -3.27e-01 7.87e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 111 2.85e-09 3.26e-01 1.23e-07
Branched-chain amino acid catabolism 21 9.67e-03 -3.26e-01 5.08e-02
Cellular response to starvation 149 8.91e-12 3.24e-01 6.21e-10
Vif-mediated degradation of APOBEC3G 52 5.62e-05 -3.23e-01 7.99e-04
Degradation of DVL 55 3.60e-05 -3.22e-01 5.61e-04
SCF-beta-TrCP mediated degradation of Emi1 53 5.11e-05 -3.22e-01 7.40e-04
Energy dependent regulation of mTOR by LKB1-AMPK 29 2.76e-03 -3.21e-01 1.83e-02
ATF6 (ATF6-alpha) activates chaperones 12 5.43e-02 3.21e-01 1.90e-01
CD28 dependent Vav1 pathway 10 7.94e-02 3.20e-01 2.58e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 5.84e-05 -3.19e-01 8.22e-04
Dectin-2 family 14 3.94e-02 3.18e-01 1.50e-01
G-protein beta:gamma signalling 26 5.08e-03 3.17e-01 3.01e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.13e-05 -3.17e-01 2.20e-04
Autodegradation of the E3 ubiquitin ligase COP1 49 1.23e-04 -3.17e-01 1.52e-03
Cap-dependent Translation Initiation 118 2.71e-09 3.17e-01 1.20e-07
Eukaryotic Translation Initiation 118 2.71e-09 3.17e-01 1.20e-07
Mitochondrial protein import 63 1.43e-05 -3.16e-01 2.65e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 1.32e-04 -3.16e-01 1.56e-03
p53-Independent DNA Damage Response 49 1.32e-04 -3.16e-01 1.56e-03
p53-Independent G1/S DNA damage checkpoint 49 1.32e-04 -3.16e-01 1.56e-03
Collagen biosynthesis and modifying enzymes 60 2.36e-05 3.16e-01 3.88e-04
SARS-CoV-2 modulates host translation machinery 49 1.33e-04 3.16e-01 1.56e-03
HSF1-dependent transactivation 33 1.73e-03 -3.15e-01 1.30e-02
Carnitine metabolism 14 4.28e-02 -3.13e-01 1.61e-01
RHO GTPases Activate WASPs and WAVEs 36 1.23e-03 3.11e-01 9.70e-03
Cardiac conduction 99 9.77e-08 -3.10e-01 3.49e-06
SUMOylation of immune response proteins 11 7.56e-02 3.09e-01 2.49e-01
Ubiquitin-dependent degradation of Cyclin D 50 1.55e-04 -3.09e-01 1.74e-03
A tetrasaccharide linker sequence is required for GAG synthesis 20 1.69e-02 3.09e-01 7.74e-02
Mitochondrial biogenesis 87 6.76e-07 -3.08e-01 2.02e-05
Negative regulation of NOTCH4 signaling 54 8.97e-05 -3.08e-01 1.16e-03
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 27 5.68e-03 3.08e-01 3.26e-02
Cross-presentation of soluble exogenous antigens (endosomes) 46 3.28e-04 -3.06e-01 3.40e-03
Glycosaminoglycan metabolism 104 6.96e-08 3.06e-01 2.55e-06
Transport of bile salts and organic acids, metal ions and amine compounds 47 2.84e-04 3.06e-01 2.99e-03
Reduction of cytosolic Ca++ levels 10 9.40e-02 -3.06e-01 2.87e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.82e-02 3.05e-01 1.76e-01
Lysine catabolism 11 8.01e-02 -3.05e-01 2.58e-01
Degradation of AXIN 53 1.25e-04 -3.05e-01 1.54e-03
TNFs bind their physiological receptors 19 2.20e-02 3.03e-01 9.49e-02
Synthesis of PIPs at the Golgi membrane 15 4.33e-02 3.01e-01 1.62e-01
Collagen formation 80 3.24e-06 3.01e-01 7.19e-05
ABC transporters in lipid homeostasis 13 6.05e-02 -3.01e-01 2.07e-01
Laminin interactions 29 5.10e-03 -3.00e-01 3.01e-02
CRMPs in Sema3A signaling 15 4.42e-02 3.00e-01 1.64e-01
Post-translational protein phosphorylation 78 5.19e-06 2.99e-01 1.12e-04
Heparan sulfate/heparin (HS-GAG) metabolism 41 9.50e-04 2.98e-01 7.85e-03
G beta:gamma signalling through PLC beta 14 5.33e-02 2.98e-01 1.89e-01
Presynaptic function of Kainate receptors 14 5.33e-02 2.98e-01 1.89e-01
Stabilization of p53 54 1.75e-04 -2.95e-01 1.91e-03
Influenza Viral RNA Transcription and Replication 135 3.27e-09 2.95e-01 1.37e-07
PKA activation in glucagon signalling 15 4.82e-02 -2.95e-01 1.76e-01
MECP2 regulates neuronal receptors and channels 14 5.63e-02 -2.95e-01 1.96e-01
ADP signalling through P2Y purinoceptor 1 19 2.71e-02 2.93e-01 1.12e-01
Defects in cobalamin (B12) metabolism 12 7.97e-02 -2.92e-01 2.58e-01
NIK–>noncanonical NF-kB signaling 57 1.37e-04 -2.92e-01 1.59e-03
ERK/MAPK targets 22 1.78e-02 -2.92e-01 7.96e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 71 2.19e-05 -2.91e-01 3.68e-04
Regulation of PTEN stability and activity 67 3.73e-05 -2.91e-01 5.69e-04
FRS-mediated FGFR4 signaling 15 5.36e-02 -2.88e-01 1.89e-01
Caspase activation via Death Receptors in the presence of ligand 15 5.68e-02 2.84e-01 1.97e-01
Cell recruitment (pro-inflammatory response) 24 1.61e-02 2.84e-01 7.46e-02
Purinergic signaling in leishmaniasis infection 24 1.61e-02 2.84e-01 7.46e-02
Activation of the AP-1 family of transcription factors 10 1.22e-01 -2.83e-01 3.35e-01
PI-3K cascade:FGFR3 12 9.27e-02 -2.80e-01 2.86e-01
VEGFR2 mediated cell proliferation 19 3.46e-02 2.80e-01 1.36e-01
Glycogen storage diseases 14 6.98e-02 -2.80e-01 2.33e-01
Maturation of spike protein 9694548 37 3.24e-03 2.80e-01 2.11e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 5.54e-04 2.80e-01 5.18e-03
Hh mutants abrogate ligand secretion 55 3.49e-04 -2.79e-01 3.59e-03
PKA-mediated phosphorylation of CREB 18 4.20e-02 -2.77e-01 1.59e-01
Intraflagellar transport 49 8.07e-04 2.77e-01 6.91e-03
MAPK targets/ Nuclear events mediated by MAP kinases 31 8.04e-03 -2.75e-01 4.40e-02
Dectin-1 mediated noncanonical NF-kB signaling 58 2.92e-04 -2.75e-01 3.05e-03
Glycosphingolipid metabolism 36 4.30e-03 2.75e-01 2.63e-02
COPI-dependent Golgi-to-ER retrograde traffic 86 1.07e-05 2.75e-01 2.14e-04
STAT3 nuclear events downstream of ALK signaling 10 1.33e-01 2.74e-01 3.56e-01
Metabolism of polyamines 56 3.91e-04 -2.74e-01 3.97e-03
Processing of SMDT1 15 6.89e-02 -2.71e-01 2.31e-01
Role of phospholipids in phagocytosis 21 3.18e-02 2.71e-01 1.27e-01
Unfolded Protein Response (UPR) 90 9.27e-06 2.70e-01 1.88e-04
Molecules associated with elastic fibres 34 6.39e-03 2.70e-01 3.61e-02
Hh mutants are degraded by ERAD 53 6.69e-04 -2.70e-01 6.00e-03
Signaling by BMP 23 2.49e-02 -2.70e-01 1.05e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 87 1.47e-05 2.69e-01 2.68e-04
Negative regulation of MAPK pathway 41 3.09e-03 -2.67e-01 2.02e-02
Collagen degradation 51 9.74e-04 2.67e-01 7.87e-03
RHO GTPases activate IQGAPs 23 2.68e-02 2.67e-01 1.11e-01
Influenza Infection 154 1.21e-08 2.66e-01 4.65e-07
Platelet Adhesion to exposed collagen 11 1.28e-01 2.65e-01 3.46e-01
Azathioprine ADME 18 5.15e-02 2.65e-01 1.85e-01
Platelet calcium homeostasis 23 2.79e-02 -2.65e-01 1.14e-01
E2F mediated regulation of DNA replication 21 3.58e-02 -2.65e-01 1.40e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 8.67e-02 2.64e-01 2.74e-01
Degradation of beta-catenin by the destruction complex 83 3.14e-05 -2.64e-01 5.10e-04
Cellular response to hypoxia 72 1.06e-04 -2.64e-01 1.34e-03
Activation of kainate receptors upon glutamate binding 21 3.63e-02 2.64e-01 1.41e-01
G beta:gamma signalling through CDC42 14 8.97e-02 2.62e-01 2.80e-01
SARS-CoV-1-host interactions 93 1.29e-05 2.62e-01 2.41e-04
Neutrophil degranulation 399 3.65e-19 2.61e-01 1.78e-16
Signaling by ERBB2 KD Mutants 23 3.11e-02 -2.60e-01 1.25e-01
ERKs are inactivated 13 1.05e-01 -2.59e-01 3.05e-01
Diseases of glycosylation 127 4.55e-07 2.59e-01 1.42e-05
Signaling by CSF1 (M-CSF) in myeloid cells 30 1.42e-02 2.59e-01 6.83e-02
Maturation of nucleoprotein 9683610 11 1.38e-01 2.59e-01 3.60e-01
Downstream signaling of activated FGFR4 20 4.63e-02 -2.57e-01 1.70e-01
Formation of paraxial mesoderm 62 4.65e-04 -2.57e-01 4.50e-03
Regulation of RUNX2 expression and activity 70 2.08e-04 -2.56e-01 2.22e-03
Myogenesis 26 2.38e-02 -2.56e-01 1.01e-01
Asymmetric localization of PCP proteins 61 5.56e-04 -2.56e-01 5.18e-03
Long-term potentiation 18 6.11e-02 -2.55e-01 2.09e-01
Signaling by ERBB2 TMD/JMD mutants 20 4.86e-02 -2.55e-01 1.77e-01
Signal amplification 25 2.75e-02 2.55e-01 1.13e-01
Keratan sulfate/keratin metabolism 32 1.27e-02 2.54e-01 6.30e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 33 1.17e-02 2.54e-01 5.86e-02
SHC-mediated cascade:FGFR4 13 1.15e-01 -2.53e-01 3.22e-01
Pentose phosphate pathway 13 1.16e-01 2.52e-01 3.25e-01
Hedgehog ligand biogenesis 60 7.45e-04 -2.52e-01 6.45e-03
Autodegradation of Cdh1 by Cdh1:APC/C 64 5.38e-04 -2.50e-01 5.11e-03
APC truncation mutants have impaired AXIN binding 14 1.05e-01 -2.50e-01 3.05e-01
AXIN missense mutants destabilize the destruction complex 14 1.05e-01 -2.50e-01 3.05e-01
Signaling by AMER1 mutants 14 1.05e-01 -2.50e-01 3.05e-01
Signaling by APC mutants 14 1.05e-01 -2.50e-01 3.05e-01
Signaling by AXIN mutants 14 1.05e-01 -2.50e-01 3.05e-01
Truncations of AMER1 destabilize the destruction complex 14 1.05e-01 -2.50e-01 3.05e-01
DARPP-32 events 23 3.83e-02 -2.50e-01 1.48e-01
Signaling by NODAL 14 1.07e-01 -2.49e-01 3.07e-01
FCERI mediated NF-kB activation 78 1.46e-04 -2.49e-01 1.67e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 9.55e-04 2.49e-01 7.85e-03
VLDLR internalisation and degradation 15 9.57e-02 2.48e-01 2.90e-01
Cytochrome c-mediated apoptotic response 13 1.21e-01 -2.48e-01 3.35e-01
Caspase activation via extrinsic apoptotic signalling pathway 23 3.99e-02 2.48e-01 1.51e-01
Interleukin-4 and Interleukin-13 signaling 87 7.03e-05 2.47e-01 9.52e-04
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 7.86e-02 2.46e-01 2.56e-01
Activation of NF-kappaB in B cells 65 6.00e-04 -2.46e-01 5.49e-03
p53-Dependent G1 DNA Damage Response 61 9.13e-04 -2.46e-01 7.59e-03
p53-Dependent G1/S DNA damage checkpoint 61 9.13e-04 -2.46e-01 7.59e-03
MTOR signalling 41 6.63e-03 -2.45e-01 3.72e-02
Depolymerization of the Nuclear Lamina 15 1.00e-01 2.45e-01 2.99e-01
Glycogen metabolism 24 3.79e-02 -2.45e-01 1.47e-01
Regulation of Complement cascade 28 2.50e-02 2.45e-01 1.05e-01
Orc1 removal from chromatin 67 5.46e-04 -2.44e-01 5.15e-03
Regulation of CDH11 Expression and Function 27 2.83e-02 2.44e-01 1.14e-01
EPH-ephrin mediated repulsion of cells 45 4.67e-03 2.44e-01 2.81e-02
APC/C:Cdc20 mediated degradation of Securin 66 6.41e-04 -2.43e-01 5.82e-03
HS-GAG degradation 21 5.42e-02 2.43e-01 1.90e-01
Unblocking of NMDA receptors, glutamate binding and activation 16 9.31e-02 -2.43e-01 2.87e-01
Signaling by NOTCH4 81 1.69e-04 -2.42e-01 1.86e-03
MASTL Facilitates Mitotic Progression 10 1.87e-01 -2.41e-01 4.26e-01
Heme biosynthesis 12 1.48e-01 -2.41e-01 3.77e-01
Regulation of FZD by ubiquitination 16 9.58e-02 -2.41e-01 2.90e-01
Intra-Golgi traffic 41 7.72e-03 2.41e-01 4.26e-02
Recycling pathway of L1 39 9.40e-03 2.40e-01 5.02e-02
Lysosome Vesicle Biogenesis 31 2.20e-02 2.38e-01 9.48e-02
G1/S DNA Damage Checkpoints 62 1.22e-03 -2.37e-01 9.70e-03
Translation initiation complex formation 58 1.82e-03 2.37e-01 1.34e-02
MAPK3 (ERK1) activation 10 1.96e-01 -2.36e-01 4.37e-01
Synaptic adhesion-like molecules 16 1.03e-01 2.36e-01 3.02e-01
Biosynthesis of specialized proresolving mediators (SPMs) 14 1.28e-01 2.35e-01 3.46e-01
Defective CFTR causes cystic fibrosis 57 2.23e-03 -2.34e-01 1.57e-02
Synthesis of IP2, IP, and Ins in the cytosol 13 1.45e-01 -2.34e-01 3.74e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 5.66e-04 2.33e-01 5.24e-03
Regulation of RUNX3 expression and activity 55 2.79e-03 -2.33e-01 1.84e-02
Elevation of cytosolic Ca2+ levels 13 1.46e-01 -2.33e-01 3.75e-01
Cytosolic iron-sulfur cluster assembly 13 1.46e-01 2.33e-01 3.75e-01
Protein methylation 15 1.20e-01 -2.32e-01 3.32e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 8.16e-02 -2.31e-01 2.61e-01
Nicotinamide salvaging 16 1.10e-01 2.31e-01 3.14e-01
NOTCH2 intracellular domain regulates transcription 10 2.07e-01 2.30e-01 4.48e-01
Prolactin receptor signaling 10 2.08e-01 -2.30e-01 4.49e-01
Downstream TCR signaling 79 4.28e-04 -2.29e-01 4.21e-03
Detoxification of Reactive Oxygen Species 33 2.27e-02 2.29e-01 9.71e-02
SCF(Skp2)-mediated degradation of p27/p21 58 2.61e-03 -2.29e-01 1.79e-02
Regulation of RAS by GAPs 65 1.45e-03 -2.28e-01 1.11e-02
LGI-ADAM interactions 11 1.90e-01 -2.28e-01 4.29e-01
Regulation of RUNX1 Expression and Activity 18 9.38e-02 2.28e-01 2.87e-01
Leishmania infection 145 2.30e-06 2.28e-01 5.17e-05
Parasitic Infection Pathways 145 2.30e-06 2.28e-01 5.17e-05
CDK-mediated phosphorylation and removal of Cdc6 69 1.11e-03 -2.27e-01 8.96e-03
SUMOylation of DNA methylation proteins 16 1.18e-01 2.26e-01 3.29e-01
Signaling by ERBB2 in Cancer 24 5.61e-02 -2.25e-01 1.95e-01
FGFR2 ligand binding and activation 10 2.18e-01 -2.25e-01 4.62e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 1.35e-01 -2.23e-01 3.56e-01
Transport of connexons to the plasma membrane 13 1.65e-01 2.22e-01 3.99e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.29e-02 2.22e-01 9.75e-02
Asparagine N-linked glycosylation 277 2.11e-10 2.22e-01 1.10e-08
Downstream signaling events of B Cell Receptor (BCR) 78 7.03e-04 -2.22e-01 6.16e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 1.40e-03 -2.21e-01 1.08e-02
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 70 1.40e-03 -2.21e-01 1.08e-02
Cargo concentration in the ER 28 4.34e-02 2.21e-01 1.62e-01
Activation of SMO 16 1.27e-01 2.20e-01 3.44e-01
Assembly of active LPL and LIPC lipase complexes 12 1.87e-01 2.20e-01 4.26e-01
RHO GTPases activate PAKs 21 8.10e-02 -2.20e-01 2.59e-01
GRB2 events in ERBB2 signaling 14 1.54e-01 -2.20e-01 3.86e-01
Neddylation 233 8.97e-09 -2.19e-01 3.65e-07
Thromboxane signalling through TP receptor 18 1.08e-01 2.19e-01 3.10e-01
CD28 co-stimulation 30 3.84e-02 2.18e-01 1.48e-01
Interleukin-12 family signaling 46 1.05e-02 2.18e-01 5.36e-02
Ribosomal scanning and start codon recognition 58 4.08e-03 2.18e-01 2.55e-02
Complement cascade 32 3.31e-02 2.18e-01 1.31e-01
Assembly of collagen fibrils and other multimeric structures 55 5.33e-03 2.17e-01 3.12e-02
Interleukin-12 signaling 40 1.76e-02 2.17e-01 7.93e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 2.35e-01 2.17e-01 4.76e-01
Assembly of the pre-replicative complex 89 4.19e-04 -2.16e-01 4.15e-03
Synthesis of substrates in N-glycan biosythesis 58 4.37e-03 2.16e-01 2.67e-02
Initial triggering of complement 15 1.47e-01 2.16e-01 3.76e-01
ROS and RNS production in phagocytes 29 4.43e-02 2.16e-01 1.64e-01
UCH proteinases 85 5.93e-04 -2.16e-01 5.45e-03
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 7.35e-02 2.16e-01 2.43e-01
G-protein activation 17 1.26e-01 2.14e-01 3.43e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 1.99e-01 2.14e-01 4.38e-01
Hyaluronan metabolism 14 1.66e-01 2.14e-01 3.99e-01
DAP12 signaling 25 6.58e-02 2.13e-01 2.22e-01
Regulated proteolysis of p75NTR 11 2.22e-01 2.13e-01 4.68e-01
Nuclear events mediated by NFE2L2 76 1.39e-03 -2.12e-01 1.08e-02
ER Quality Control Compartment (ERQC) 21 9.26e-02 2.12e-01 2.86e-01
MAPK6/MAPK4 signaling 84 7.88e-04 -2.12e-01 6.78e-03
Packaging Of Telomere Ends 13 1.87e-01 -2.12e-01 4.26e-01
RAF-independent MAPK1/3 activation 21 9.36e-02 -2.11e-01 2.87e-01
COPII-mediated vesicle transport 63 3.81e-03 2.11e-01 2.41e-02
ABC transporter disorders 69 2.49e-03 -2.11e-01 1.72e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 48 1.18e-02 -2.10e-01 5.87e-02
Listeria monocytogenes entry into host cells 17 1.34e-01 2.10e-01 3.56e-01
MHC class II antigen presentation 95 4.07e-04 2.10e-01 4.08e-03
CTNNB1 S33 mutants aren’t phosphorylated 15 1.60e-01 -2.10e-01 3.91e-01
CTNNB1 S37 mutants aren’t phosphorylated 15 1.60e-01 -2.10e-01 3.91e-01
CTNNB1 S45 mutants aren’t phosphorylated 15 1.60e-01 -2.10e-01 3.91e-01
CTNNB1 T41 mutants aren’t phosphorylated 15 1.60e-01 -2.10e-01 3.91e-01
Signaling by CTNNB1 phospho-site mutants 15 1.60e-01 -2.10e-01 3.91e-01
Signaling by GSK3beta mutants 15 1.60e-01 -2.10e-01 3.91e-01
Tryptophan catabolism 10 2.51e-01 2.10e-01 4.89e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 15 1.60e-01 2.10e-01 3.91e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 15 1.60e-01 2.10e-01 3.91e-01
Negative regulation of FGFR4 signaling 24 7.72e-02 -2.08e-01 2.53e-01
Pexophagy 11 2.32e-01 -2.08e-01 4.75e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 72 2.33e-03 -2.08e-01 1.62e-02
Regulation of Expression and Function of Type II Classical Cadherins 29 5.36e-02 2.07e-01 1.89e-01
Regulation of Homotypic Cell-Cell Adhesion 29 5.36e-02 2.07e-01 1.89e-01
MAP kinase activation 63 4.51e-03 -2.07e-01 2.74e-02
Adenylate cyclase inhibitory pathway 12 2.15e-01 -2.07e-01 4.58e-01
Golgi-to-ER retrograde transport 119 1.06e-04 2.06e-01 1.34e-03
Signaling by FLT3 fusion proteins 19 1.21e-01 2.05e-01 3.35e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.69e-01 -2.05e-01 4.01e-01
RNA Polymerase III Transcription Termination 23 8.90e-02 -2.05e-01 2.79e-01
Extracellular matrix organization 248 3.17e-08 2.04e-01 1.19e-06
Thrombin signalling through proteinase activated receptors (PARs) 24 8.34e-02 2.04e-01 2.65e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 2.03e-01 -2.04e-01 4.44e-01
Trafficking of GluR2-containing AMPA receptors 14 1.87e-01 2.04e-01 4.26e-01
ABC-family proteins mediated transport 93 6.88e-04 -2.04e-01 6.09e-03
FCERI mediated Ca+2 mobilization 29 5.80e-02 2.03e-01 2.00e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 185 2.22e-06 2.02e-01 5.17e-05
Regulation of signaling by CBL 22 1.01e-01 2.02e-01 2.99e-01
DNA Replication Pre-Initiation 103 4.04e-04 -2.02e-01 4.07e-03
ER to Golgi Anterograde Transport 139 4.24e-05 2.01e-01 6.26e-04
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 2.09e-01 2.01e-01 4.51e-01
Signaling by FGFR3 in disease 16 1.64e-01 -2.01e-01 3.99e-01
Metabolism of nitric oxide: NOS3 activation and regulation 15 1.78e-01 -2.01e-01 4.16e-01
Activation of AMPK downstream of NMDARs 21 1.11e-01 -2.01e-01 3.15e-01
Incretin synthesis, secretion, and inactivation 13 2.12e-01 2.00e-01 4.55e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 2.12e-01 2.00e-01 4.55e-01
RNA Polymerase I Promoter Opening 10 2.75e-01 -1.99e-01 5.19e-01
Sema3A PAK dependent Axon repulsion 16 1.67e-01 1.99e-01 3.99e-01
Rap1 signalling 13 2.13e-01 -1.99e-01 4.57e-01
Killing mechanisms 10 2.76e-01 1.99e-01 5.19e-01
WNT5:FZD7-mediated leishmania damping 10 2.76e-01 1.99e-01 5.19e-01
Regulation of TLR by endogenous ligand 15 1.85e-01 1.98e-01 4.26e-01
SARS-CoV-1 Infection 135 7.47e-05 1.98e-01 1.00e-03
Regulation of APC/C activators between G1/S and early anaphase 78 2.66e-03 -1.97e-01 1.81e-02
RUNX2 regulates osteoblast differentiation 21 1.19e-01 1.96e-01 3.32e-01
trans-Golgi Network Vesicle Budding 68 5.13e-03 1.96e-01 3.01e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 15 1.88e-01 -1.96e-01 4.28e-01
Translation of Structural Proteins 9694635 57 1.04e-02 1.96e-01 5.36e-02
COPI-mediated anterograde transport 90 1.30e-03 1.96e-01 1.02e-02
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 2.40e-01 1.96e-01 4.80e-01
Amine ligand-binding receptors 11 2.62e-01 -1.95e-01 5.03e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 73 3.97e-03 -1.95e-01 2.50e-02
Signaling by PDGFRA extracellular domain mutants 12 2.43e-01 1.95e-01 4.83e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 2.43e-01 1.95e-01 4.83e-01
PI-3K cascade:FGFR1 13 2.24e-01 -1.95e-01 4.71e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 6.84e-06 1.95e-01 1.41e-04
Plasma lipoprotein clearance 32 5.69e-02 1.95e-01 1.97e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 1.77e-03 -1.94e-01 1.32e-02
PINK1-PRKN Mediated Mitophagy 21 1.24e-01 -1.94e-01 3.41e-01
PI-3K cascade:FGFR2 14 2.09e-01 -1.94e-01 4.51e-01
InlB-mediated entry of Listeria monocytogenes into host cell 13 2.28e-01 1.93e-01 4.75e-01
Chemokine receptors bind chemokines 32 5.89e-02 1.93e-01 2.02e-01
Triglyceride metabolism 24 1.02e-01 -1.93e-01 3.01e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 4.73e-03 -1.93e-01 2.83e-02
Protein localization 155 3.85e-05 -1.92e-01 5.80e-04
Crosslinking of collagen fibrils 18 1.59e-01 1.92e-01 3.91e-01
Other semaphorin interactions 19 1.48e-01 1.92e-01 3.77e-01
TRAF3-dependent IRF activation pathway 13 2.32e-01 1.92e-01 4.75e-01
CD28 dependent PI3K/Akt signaling 20 1.38e-01 1.92e-01 3.61e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 1.61e-01 1.91e-01 3.91e-01
Ub-specific processing proteases 157 3.73e-05 -1.91e-01 5.69e-04
Switching of origins to a post-replicative state 87 2.17e-03 -1.90e-01 1.55e-02
Negative regulation of MET activity 19 1.51e-01 1.90e-01 3.81e-01
Activation of G protein gated Potassium channels 18 1.68e-01 1.88e-01 3.99e-01
G protein gated Potassium channels 18 1.68e-01 1.88e-01 3.99e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 1.68e-01 1.88e-01 3.99e-01
Resolution of D-Loop Structures 33 6.35e-02 1.87e-01 2.15e-01
P2Y receptors 10 3.07e-01 -1.87e-01 5.57e-01
Signaling by Activin 14 2.28e-01 -1.86e-01 4.75e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 2.85e-01 -1.86e-01 5.31e-01
FRS-mediated FGFR3 signaling 14 2.30e-01 -1.85e-01 4.75e-01
Transport to the Golgi and subsequent modification 164 4.35e-05 1.85e-01 6.37e-04
EPHB-mediated forward signaling 40 4.33e-02 1.85e-01 1.62e-01
Interleukin receptor SHC signaling 20 1.55e-01 1.84e-01 3.88e-01
Innate Immune System 833 6.74e-19 1.82e-01 2.47e-16
rRNA processing in the nucleus and cytosol 190 1.57e-05 1.82e-01 2.79e-04
RAF/MAP kinase cascade 233 1.81e-06 -1.82e-01 4.40e-05
Late SARS-CoV-2 Infection Events 66 1.07e-02 1.82e-01 5.47e-02
Transcriptional activation of mitochondrial biogenesis 50 2.68e-02 -1.81e-01 1.11e-01
Metabolism of folate and pterines 17 1.97e-01 1.81e-01 4.37e-01
MAPK1/MAPK3 signaling 239 1.64e-06 -1.80e-01 4.13e-05
Downstream signaling of activated FGFR3 19 1.74e-01 -1.80e-01 4.10e-01
Defective B4GALT7 causes EDS, progeroid type 16 2.14e-01 1.79e-01 4.57e-01
Metabolism of carbohydrates 253 9.28e-07 1.79e-01 2.66e-05
Resolution of D-loop Structures through Holliday Junction Intermediates 32 7.91e-02 1.79e-01 2.57e-01
Sema4D induced cell migration and growth-cone collapse 20 1.65e-01 -1.79e-01 3.99e-01
Cell surface interactions at the vascular wall 102 1.86e-03 1.78e-01 1.36e-02
Gastrin-CREB signalling pathway via PKC and MAPK 16 2.17e-01 1.78e-01 4.60e-01
Attenuation phase 23 1.42e-01 -1.77e-01 3.68e-01
Nuclear events stimulated by ALK signaling in cancer 17 2.07e-01 1.77e-01 4.48e-01
Cilium Assembly 185 3.40e-05 1.77e-01 5.41e-04
KEAP1-NFE2L2 pathway 101 2.21e-03 -1.76e-01 1.56e-02
Mitochondrial iron-sulfur cluster biogenesis 13 2.71e-01 -1.76e-01 5.15e-01
RHO GTPases Activate ROCKs 19 1.84e-01 -1.76e-01 4.26e-01
Gastrulation 85 5.09e-03 -1.76e-01 3.01e-02
Golgi Associated Vesicle Biogenesis 54 2.56e-02 1.76e-01 1.07e-01
Surfactant metabolism 18 1.98e-01 -1.75e-01 4.37e-01
Interleukin-17 signaling 66 1.38e-02 -1.75e-01 6.71e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 69 1.18e-02 -1.75e-01 5.88e-02
Signaling by WNT in cancer 29 1.03e-01 -1.75e-01 3.03e-01
Signaling by FGFR4 34 7.79e-02 -1.75e-01 2.54e-01
RAB GEFs exchange GTP for GDP on RABs 84 5.67e-03 1.75e-01 3.26e-02
Post NMDA receptor activation events 64 1.59e-02 -1.74e-01 7.44e-02
SUMOylation of transcription factors 16 2.27e-01 1.74e-01 4.75e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 3.18e-01 1.74e-01 5.70e-01
Plasma lipoprotein assembly, remodeling, and clearance 55 2.60e-02 1.74e-01 1.08e-01
Interleukin-1 signaling 108 1.85e-03 -1.74e-01 1.35e-02
Platelet homeostasis 70 1.22e-02 -1.73e-01 6.04e-02
Infection with Mycobacterium tuberculosis 25 1.34e-01 1.73e-01 3.56e-01
Transcriptional Regulation by MECP2 49 3.64e-02 -1.73e-01 1.42e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 1.61e-01 1.73e-01 3.91e-01
PECAM1 interactions 11 3.22e-01 1.73e-01 5.72e-01
Intrinsic Pathway of Fibrin Clot Formation 12 3.02e-01 -1.72e-01 5.51e-01
Regulation of IFNA/IFNB signaling 12 3.04e-01 1.71e-01 5.53e-01
Processive synthesis on the lagging strand 15 2.50e-01 1.71e-01 4.89e-01
Formation of tubulin folding intermediates by CCT/TriC 20 1.84e-01 -1.71e-01 4.26e-01
Cytosolic tRNA aminoacylation 24 1.48e-01 1.71e-01 3.77e-01
ECM proteoglycans 63 1.95e-02 1.70e-01 8.55e-02
G alpha (12/13) signalling events 68 1.55e-02 1.70e-01 7.34e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.28e-02 1.70e-01 6.31e-02
Negative regulation of FLT3 13 2.90e-01 1.70e-01 5.37e-01
Mitochondrial Fatty Acid Beta-Oxidation 34 8.72e-02 -1.70e-01 2.75e-01
Transport of Mature Transcript to Cytoplasm 81 8.43e-03 1.69e-01 4.58e-02
Activation of NMDA receptors and postsynaptic events 75 1.12e-02 -1.69e-01 5.65e-02
Pyruvate metabolism 27 1.28e-01 -1.69e-01 3.46e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.43e-01 -1.69e-01 4.83e-01
Ras activation upon Ca2+ influx through NMDA receptor 16 2.45e-01 -1.68e-01 4.86e-01
p75 NTR receptor-mediated signalling 91 5.71e-03 1.68e-01 3.26e-02
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 3.59e-01 -1.67e-01 6.13e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 6.39e-02 1.67e-01 2.16e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 1.96e-01 -1.67e-01 4.37e-01
Cyclin E associated events during G1/S transition 80 9.97e-03 -1.67e-01 5.17e-02
Defective B3GAT3 causes JDSSDHD 16 2.48e-01 1.67e-01 4.89e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 16 2.49e-01 1.66e-01 4.89e-01
Signaling by ALK 26 1.42e-01 1.66e-01 3.69e-01
Cyclin A/B1/B2 associated events during G2/M transition 22 1.77e-01 -1.66e-01 4.15e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 12 3.19e-01 -1.66e-01 5.71e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 8.50e-02 1.66e-01 2.69e-01
Downregulation of ERBB2 signaling 27 1.36e-01 -1.66e-01 3.60e-01
Cytosolic sulfonation of small molecules 18 2.27e-01 1.65e-01 4.75e-01
Binding and Uptake of Ligands by Scavenger Receptors 33 1.02e-01 1.64e-01 3.01e-01
Signaling by PDGF 54 3.73e-02 1.64e-01 1.45e-01
TCF dependent signaling in response to WNT 160 3.64e-04 -1.63e-01 3.73e-03
MET activates PTK2 signaling 29 1.28e-01 1.63e-01 3.46e-01
APC/C-mediated degradation of cell cycle proteins 84 9.73e-03 -1.63e-01 5.08e-02
Regulation of mitotic cell cycle 84 9.73e-03 -1.63e-01 5.08e-02
Keratan sulfate biosynthesis 26 1.52e-01 1.62e-01 3.82e-01
Antigen processing: Ubiquitination & Proteasome degradation 293 1.91e-06 -1.62e-01 4.57e-05
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 1.13e-01 1.62e-01 3.19e-01
Transcriptional Regulation by VENTX 39 8.04e-02 1.62e-01 2.58e-01
Biosynthesis of DHA-derived SPMs 12 3.32e-01 1.62e-01 5.86e-01
CDC42 GTPase cycle 148 6.91e-04 1.62e-01 6.09e-03
Ion transport by P-type ATPases 43 6.71e-02 -1.61e-01 2.26e-01
Regulation of TP53 Activity through Acetylation 29 1.33e-01 1.61e-01 3.56e-01
TBC/RABGAPs 43 6.79e-02 1.61e-01 2.28e-01
MAPK family signaling cascades 275 4.54e-06 -1.61e-01 9.90e-05
Diseases of metabolism 206 7.00e-05 1.61e-01 9.52e-04
Aspirin ADME 16 2.65e-01 1.61e-01 5.08e-01
Response to elevated platelet cytosolic Ca2+ 112 3.54e-03 1.60e-01 2.26e-02
SHC1 events in ERBB4 signaling 12 3.39e-01 -1.59e-01 5.96e-01
Transcriptional regulation of pluripotent stem cells 17 2.57e-01 -1.59e-01 4.97e-01
Metalloprotease DUBs 19 2.31e-01 -1.59e-01 4.75e-01
Integrin cell surface interactions 74 1.86e-02 1.58e-01 8.28e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.33e-01 -1.58e-01 3.56e-01
Glycogen breakdown (glycogenolysis) 14 3.05e-01 -1.58e-01 5.55e-01
SARS-CoV Infections 371 1.84e-07 1.58e-01 6.24e-06
Cyclin A:Cdk2-associated events at S phase entry 82 1.34e-02 -1.58e-01 6.57e-02
Inhibition of DNA recombination at telomere 27 1.59e-01 -1.57e-01 3.91e-01
Beta-catenin phosphorylation cascade 17 2.64e-01 -1.56e-01 5.07e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 3.49e-01 -1.56e-01 6.05e-01
SLC-mediated transmembrane transport 160 6.74e-04 1.56e-01 6.01e-03
CASP8 activity is inhibited 10 3.94e-01 1.56e-01 6.40e-01
Dimerization of procaspase-8 10 3.94e-01 1.56e-01 6.40e-01
Regulation by c-FLIP 10 3.94e-01 1.56e-01 6.40e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.78e-01 1.56e-01 4.16e-01
Regulation of KIT signaling 15 2.96e-01 1.56e-01 5.44e-01
rRNA processing 200 1.50e-04 1.56e-01 1.70e-03
FGFR2 mutant receptor activation 24 1.89e-01 -1.55e-01 4.29e-01
SARS-CoV-2-host interactions 175 4.20e-04 1.55e-01 4.15e-03
DNA Replication 127 2.66e-03 -1.55e-01 1.81e-02
RUNX2 regulates bone development 27 1.65e-01 1.54e-01 3.99e-01
Transcriptional regulation by RUNX3 95 9.36e-03 -1.54e-01 5.02e-02
Peroxisomal protein import 56 4.60e-02 -1.54e-01 1.70e-01
NR1H2 and NR1H3-mediated signaling 39 9.64e-02 1.54e-01 2.90e-01
Defects in vitamin and cofactor metabolism 20 2.34e-01 -1.54e-01 4.76e-01
RNA Polymerase III Abortive And Retractive Initiation 41 9.01e-02 -1.53e-01 2.80e-01
RNA Polymerase III Transcription 41 9.01e-02 -1.53e-01 2.80e-01
Hedgehog ‘on’ state 82 1.67e-02 -1.53e-01 7.69e-02
Signaling by NTRK3 (TRKC) 17 2.77e-01 1.52e-01 5.19e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 3.42e-01 -1.52e-01 5.98e-01
Mitochondrial tRNA aminoacylation 21 2.27e-01 -1.52e-01 4.75e-01
RHO GTPases activate PKNs 37 1.10e-01 -1.52e-01 3.14e-01
Rab regulation of trafficking 115 5.08e-03 1.51e-01 3.01e-02
Translation of Structural Proteins 9683701 29 1.59e-01 1.51e-01 3.91e-01
RAC2 GTPase cycle 85 1.67e-02 1.50e-01 7.69e-02
O-glycosylation of TSR domain-containing proteins 36 1.20e-01 1.50e-01 3.32e-01
Signaling by MET 74 2.61e-02 1.50e-01 1.08e-01
The canonical retinoid cycle in rods (twilight vision) 11 3.91e-01 1.50e-01 6.40e-01
CaM pathway 31 1.50e-01 -1.49e-01 3.80e-01
Calmodulin induced events 31 1.50e-01 -1.49e-01 3.80e-01
mRNA 3’-end processing 57 5.13e-02 1.49e-01 1.85e-01
Sema4D in semaphorin signaling 24 2.06e-01 -1.49e-01 4.48e-01
TCR signaling 98 1.08e-02 -1.49e-01 5.48e-02
G2/M Checkpoints 124 4.17e-03 -1.49e-01 2.59e-02
IRAK2 mediated activation of TAK1 complex 10 4.15e-01 -1.49e-01 6.59e-01
Signaling by NOTCH3 44 9.09e-02 -1.47e-01 2.82e-01
SARS-CoV-2 Infection 263 4.10e-05 1.47e-01 6.12e-04
TRAF6 mediated IRF7 activation 15 3.24e-01 1.47e-01 5.74e-01
Glycolysis 66 3.93e-02 1.47e-01 1.50e-01
Platelet activation, signaling and aggregation 219 1.87e-04 1.47e-01 2.02e-03
MET promotes cell motility 39 1.13e-01 1.47e-01 3.20e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 3.81e-01 1.46e-01 6.30e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 2.58e-01 -1.46e-01 4.98e-01
Interconversion of nucleotide di- and triphosphates 27 1.89e-01 1.46e-01 4.29e-01
CLEC7A (Dectin-1) signaling 95 1.41e-02 -1.46e-01 6.79e-02
mRNA decay by 3’ to 5’ exoribonuclease 13 3.65e-01 -1.45e-01 6.18e-01
RHOBTB1 GTPase cycle 23 2.29e-01 -1.45e-01 4.75e-01
Anchoring of the basal body to the plasma membrane 94 1.58e-02 1.44e-01 7.39e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 2.22e-01 -1.44e-01 4.68e-01
FLT3 signaling in disease 27 1.97e-01 1.44e-01 4.37e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 2.79e-01 1.44e-01 5.21e-01
Leading Strand Synthesis 14 3.53e-01 1.43e-01 6.10e-01
Polymerase switching 14 3.53e-01 1.43e-01 6.10e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23 2.34e-01 -1.43e-01 4.76e-01
SUMOylation of DNA replication proteins 45 9.67e-02 1.43e-01 2.90e-01
Regulation of expression of SLITs and ROBOs 161 1.81e-03 1.43e-01 1.34e-02
Negative regulation of FGFR3 signaling 23 2.37e-01 -1.42e-01 4.77e-01
Platelet degranulation 108 1.06e-02 1.42e-01 5.45e-02
Sphingolipid metabolism 73 3.62e-02 1.42e-01 1.41e-01
Potential therapeutics for SARS 90 2.02e-02 1.42e-01 8.78e-02
TP53 Regulates Transcription of Caspase Activators and Caspases 11 4.17e-01 1.41e-01 6.61e-01
Degradation of cysteine and homocysteine 14 3.60e-01 -1.41e-01 6.13e-01
SLC transporter disorders 69 4.30e-02 1.41e-01 1.62e-01
Lewis blood group biosynthesis 10 4.41e-01 1.41e-01 6.79e-01
Transferrin endocytosis and recycling 27 2.06e-01 1.41e-01 4.48e-01
TP53 Regulates Metabolic Genes 81 2.90e-02 -1.40e-01 1.17e-01
Interleukin-37 signaling 20 2.78e-01 1.40e-01 5.20e-01
SUMOylation of transcription cofactors 44 1.08e-01 1.40e-01 3.10e-01
Fanconi Anemia Pathway 35 1.52e-01 1.40e-01 3.82e-01
MyD88 cascade initiated on plasma membrane 94 1.92e-02 -1.40e-01 8.46e-02
Toll Like Receptor 10 (TLR10) Cascade 94 1.92e-02 -1.40e-01 8.46e-02
Toll Like Receptor 5 (TLR5) Cascade 94 1.92e-02 -1.40e-01 8.46e-02
Synthesis of DNA 115 9.67e-03 -1.40e-01 5.08e-02
Removal of the Flap Intermediate 14 3.66e-01 1.39e-01 6.18e-01
HDACs deacetylate histones 37 1.42e-01 1.39e-01 3.69e-01
RHO GTPases activate CIT 19 2.93e-01 -1.39e-01 5.40e-01
VEGFA-VEGFR2 Pathway 95 1.93e-02 1.39e-01 8.46e-02
Unwinding of DNA 11 4.25e-01 1.39e-01 6.68e-01
Immune System 1591 8.14e-20 1.39e-01 5.95e-17
Downstream signaling of activated FGFR1 21 2.75e-01 -1.38e-01 5.19e-01
Plasma lipoprotein remodeling 19 2.99e-01 1.38e-01 5.48e-01
FLT3 Signaling 34 1.66e-01 1.37e-01 3.99e-01
Cell death signalling via NRAGE, NRIF and NADE 73 4.28e-02 1.37e-01 1.61e-01
DNA methylation 11 4.33e-01 -1.37e-01 6.72e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 3.77e-01 1.36e-01 6.27e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 4.34e-01 1.36e-01 6.72e-01
Signaling by FLT3 ITD and TKD mutants 15 3.62e-01 1.36e-01 6.14e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.33e-01 -1.36e-01 5.87e-01
HSF1 activation 26 2.32e-01 -1.36e-01 4.75e-01
Germ layer formation at gastrulation 10 4.58e-01 1.36e-01 6.89e-01
Processing and activation of SUMO 10 4.58e-01 -1.35e-01 6.89e-01
mTORC1-mediated signalling 24 2.51e-01 -1.35e-01 4.89e-01
Iron uptake and transport 53 8.87e-02 1.35e-01 2.78e-01
Costimulation by the CD28 family 48 1.06e-01 1.35e-01 3.06e-01
RHOU GTPase cycle 39 1.45e-01 1.35e-01 3.74e-01
Deubiquitination 228 4.86e-04 -1.34e-01 4.65e-03
Suppression of phagosomal maturation 12 4.21e-01 1.34e-01 6.65e-01
Infectious disease 817 1.03e-10 1.34e-01 5.77e-09
activated TAK1 mediates p38 MAPK activation 23 2.70e-01 -1.33e-01 5.13e-01
RIP-mediated NFkB activation via ZBP1 16 3.59e-01 1.33e-01 6.13e-01
Sensory perception of taste 15 3.75e-01 -1.32e-01 6.25e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 2.52e-01 -1.32e-01 4.90e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 3.92e-01 1.32e-01 6.40e-01
Downstream signaling of activated FGFR2 21 2.95e-01 -1.32e-01 5.42e-01
Cellular hexose transport 14 3.93e-01 1.32e-01 6.40e-01
Transcriptional Regulation by E2F6 34 1.83e-01 1.32e-01 4.25e-01
RAC1 GTPase cycle 175 2.73e-03 1.31e-01 1.83e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 2.76e-01 -1.31e-01 5.19e-01
SARS-CoV-1 activates/modulates innate immune responses 39 1.56e-01 1.31e-01 3.89e-01
Phase 2 - plateau phase 11 4.52e-01 -1.31e-01 6.87e-01
Response of Mtb to phagocytosis 22 2.90e-01 1.30e-01 5.38e-01
SHC-mediated cascade:FGFR3 12 4.35e-01 -1.30e-01 6.72e-01
Sulfur amino acid metabolism 25 2.62e-01 -1.30e-01 5.03e-01
RHOBTB GTPase Cycle 35 1.85e-01 -1.29e-01 4.26e-01
G1/S Transition 124 1.31e-02 -1.29e-01 6.41e-02
SUMOylation of intracellular receptors 27 2.46e-01 -1.29e-01 4.87e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 4.59e-01 -1.29e-01 6.89e-01
Apoptotic factor-mediated response 20 3.20e-01 -1.29e-01 5.71e-01
Aflatoxin activation and detoxification 12 4.41e-01 1.28e-01 6.79e-01
Selective autophagy 71 6.21e-02 -1.28e-01 2.11e-01
Signaling by FGFR3 34 1.98e-01 -1.28e-01 4.37e-01
Negative regulation of FGFR1 signaling 25 2.69e-01 -1.28e-01 5.13e-01
Bacterial Infection Pathways 61 8.49e-02 1.28e-01 2.69e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 9.70e-02 -1.27e-01 2.90e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 9.70e-02 -1.27e-01 2.90e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 9.70e-02 -1.27e-01 2.90e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 9.70e-02 -1.27e-01 2.90e-01
Signaling by NOTCH1 in Cancer 57 9.70e-02 -1.27e-01 2.90e-01
Defective B3GALTL causes PpS 35 1.93e-01 1.27e-01 4.35e-01
Nuclear Envelope Breakdown 53 1.11e-01 1.27e-01 3.15e-01
Hedgehog ‘off’ state 105 2.55e-02 -1.26e-01 1.07e-01
RHOF GTPase cycle 39 1.74e-01 1.26e-01 4.10e-01
Reproduction 66 7.72e-02 1.26e-01 2.53e-01
Association of TriC/CCT with target proteins during biosynthesis 34 2.04e-01 -1.26e-01 4.47e-01
Transcription of E2F targets under negative control by DREAM complex 18 3.55e-01 1.26e-01 6.12e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 4.33e-01 1.26e-01 6.72e-01
RNA Polymerase II Transcription Termination 66 7.78e-02 1.26e-01 2.54e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 2.68e-01 1.26e-01 5.12e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.51e-01 -1.25e-01 4.89e-01
Signaling by NOTCH 177 4.10e-03 -1.25e-01 2.55e-02
Signaling by VEGF 104 2.76e-02 1.25e-01 1.13e-01
Receptor-type tyrosine-protein phosphatases 13 4.36e-01 1.25e-01 6.73e-01
NRAGE signals death through JNK 56 1.07e-01 1.25e-01 3.07e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 56 1.08e-01 1.24e-01 3.10e-01
DNA strand elongation 31 2.32e-01 1.24e-01 4.75e-01
Erythropoietin activates RAS 13 4.42e-01 1.23e-01 6.79e-01
Apoptosis 161 7.09e-03 -1.23e-01 3.93e-02
SIRT1 negatively regulates rRNA expression 15 4.09e-01 -1.23e-01 6.53e-01
SUMOylation of RNA binding proteins 47 1.45e-01 1.23e-01 3.74e-01
Interleukin-1 family signaling 135 1.38e-02 -1.23e-01 6.71e-02
DAG and IP3 signaling 37 1.96e-01 -1.23e-01 4.37e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 3.97e-01 1.22e-01 6.42e-01
Mismatch Repair 14 4.29e-01 1.22e-01 6.71e-01
Regulation of innate immune responses to cytosolic DNA 13 4.46e-01 1.22e-01 6.82e-01
Vesicle-mediated transport 596 4.34e-07 1.22e-01 1.38e-05
Nuclear Receptor transcription pathway 42 1.73e-01 -1.22e-01 4.09e-01
Signaling by ROBO receptors 200 3.06e-03 1.22e-01 2.01e-02
FRS-mediated FGFR2 signaling 16 4.01e-01 -1.21e-01 6.47e-01
Gap junction trafficking and regulation 32 2.35e-01 1.21e-01 4.76e-01
Interactions of Rev with host cellular proteins 37 2.02e-01 1.21e-01 4.43e-01
IRAK1 recruits IKK complex 14 4.33e-01 -1.21e-01 6.72e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 4.33e-01 -1.21e-01 6.72e-01
EPH-Ephrin signaling 84 5.61e-02 1.21e-01 1.95e-01
TP53 Regulates Transcription of Cell Death Genes 40 1.88e-01 1.20e-01 4.28e-01
Metabolism of Angiotensinogen to Angiotensins 13 4.54e-01 -1.20e-01 6.88e-01
Gap junction trafficking 30 2.57e-01 1.20e-01 4.97e-01
Anchoring fibril formation 15 4.22e-01 -1.20e-01 6.66e-01
Nuclear import of Rev protein 34 2.29e-01 1.19e-01 4.75e-01
Transport of vitamins, nucleosides, and related molecules 29 2.67e-01 1.19e-01 5.10e-01
Membrane Trafficking 566 1.41e-06 1.19e-01 3.68e-05
Interleukin-2 family signaling 33 2.37e-01 1.19e-01 4.77e-01
FOXO-mediated transcription of cell cycle genes 16 4.10e-01 -1.19e-01 6.53e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 12 4.76e-01 -1.19e-01 7.06e-01
PI Metabolism 78 6.98e-02 1.19e-01 2.33e-01
Synthesis of PIPs at the plasma membrane 50 1.46e-01 1.19e-01 3.75e-01
Neurexins and neuroligins 38 2.05e-01 1.19e-01 4.48e-01
Cellular response to heat stress 97 4.35e-02 -1.19e-01 1.62e-01
Signaling by FGFR2 in disease 34 2.32e-01 -1.19e-01 4.75e-01
Degradation of the extracellular matrix 109 3.28e-02 1.18e-01 1.30e-01
Mitophagy 28 2.80e-01 -1.18e-01 5.23e-01
FRS-mediated FGFR1 signaling 15 4.32e-01 -1.17e-01 6.72e-01
PTEN Regulation 138 1.77e-02 -1.17e-01 7.93e-02
Fc epsilon receptor (FCERI) signaling 126 2.37e-02 -1.17e-01 1.00e-01
Signalling to RAS 20 3.67e-01 1.17e-01 6.18e-01
Ca-dependent events 33 2.47e-01 -1.16e-01 4.89e-01
Recruitment of NuMA to mitotic centrosomes 86 6.25e-02 1.16e-01 2.12e-01
Cleavage of the damaged pyrimidine 21 3.57e-01 -1.16e-01 6.12e-01
Depyrimidination 21 3.57e-01 -1.16e-01 6.12e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 21 3.57e-01 -1.16e-01 6.12e-01
Signaling by FGFR4 in disease 11 5.05e-01 -1.16e-01 7.25e-01
Lagging Strand Synthesis 20 3.70e-01 1.16e-01 6.23e-01
Cleavage of the damaged purine 16 4.24e-01 -1.16e-01 6.66e-01
Depurination 16 4.24e-01 -1.16e-01 6.66e-01
Recognition and association of DNA glycosylase with site containing an affected purine 16 4.24e-01 -1.16e-01 6.66e-01
RHO GTPase Effectors 243 2.01e-03 1.15e-01 1.45e-02
Interferon alpha/beta signaling 57 1.33e-01 1.15e-01 3.56e-01
Sensory Perception 146 1.66e-02 -1.15e-01 7.69e-02
GABA synthesis, release, reuptake and degradation 11 5.10e-01 -1.15e-01 7.27e-01
Collagen chain trimerization 37 2.29e-01 1.14e-01 4.75e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 27 3.07e-01 -1.14e-01 5.57e-01
NOTCH1 Intracellular Domain Regulates Transcription 47 1.78e-01 -1.13e-01 4.16e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 2.76e-01 1.13e-01 5.19e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 2.76e-01 1.13e-01 5.19e-01
Integrin signaling 23 3.48e-01 1.13e-01 6.05e-01
Viral Infection Pathways 652 9.58e-07 1.13e-01 2.70e-05
Transport of Mature mRNAs Derived from Intronless Transcripts 43 2.01e-01 1.13e-01 4.42e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 2.43e-01 1.13e-01 4.83e-01
Polo-like kinase mediated events 14 4.66e-01 1.13e-01 6.99e-01
eNOS activation 11 5.18e-01 -1.13e-01 7.34e-01
Impaired BRCA2 binding to PALB2 23 3.50e-01 1.12e-01 6.07e-01
Retrograde transport at the Trans-Golgi-Network 49 1.74e-01 1.12e-01 4.10e-01
RNA Polymerase III Chain Elongation 18 4.10e-01 -1.12e-01 6.53e-01
Synthesis of very long-chain fatty acyl-CoAs 19 3.98e-01 -1.12e-01 6.44e-01
Prefoldin mediated transfer of substrate to CCT/TriC 25 3.33e-01 -1.12e-01 5.87e-01
GPER1 signaling 36 2.45e-01 1.12e-01 4.87e-01
Signaling by ERBB2 ECD mutants 16 4.38e-01 -1.12e-01 6.76e-01
Activation of Matrix Metalloproteinases 21 3.75e-01 1.12e-01 6.25e-01
Peroxisomal lipid metabolism 26 3.24e-01 -1.12e-01 5.74e-01
TP53 Regulates Transcription of Cell Cycle Genes 43 2.06e-01 1.12e-01 4.48e-01
Netrin-1 signaling 42 2.13e-01 -1.11e-01 4.57e-01
Nucleotide catabolism 27 3.18e-01 1.11e-01 5.70e-01
Interleukin-7 signaling 19 4.03e-01 -1.11e-01 6.49e-01
Anti-inflammatory response favouring Leishmania parasite infection 64 1.25e-01 1.11e-01 3.42e-01
Leishmania parasite growth and survival 64 1.25e-01 1.11e-01 3.42e-01
Nucleotide biosynthesis 12 5.07e-01 1.11e-01 7.26e-01
EGFR downregulation 25 3.40e-01 -1.10e-01 5.96e-01
Toll Like Receptor 3 (TLR3) Cascade 103 5.42e-02 -1.10e-01 1.90e-01
Signaling by Leptin 11 5.29e-01 -1.10e-01 7.41e-01
Synthesis of PE 12 5.11e-01 1.10e-01 7.29e-01
Signaling by ALK fusions and activated point mutants 53 1.68e-01 1.09e-01 4.00e-01
Signaling by ALK in cancer 53 1.68e-01 1.09e-01 4.00e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 4.12e-01 -1.09e-01 6.55e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 12 5.15e-01 -1.09e-01 7.30e-01
HIV elongation arrest and recovery 32 2.89e-01 1.08e-01 5.36e-01
Pausing and recovery of HIV elongation 32 2.89e-01 1.08e-01 5.36e-01
Activation of RAC1 11 5.34e-01 -1.08e-01 7.43e-01
Condensation of Prometaphase Chromosomes 11 5.34e-01 1.08e-01 7.43e-01
Sensory processing of sound by inner hair cells of the cochlea 47 1.99e-01 1.08e-01 4.38e-01
Pregnenolone biosynthesis 10 5.55e-01 1.08e-01 7.59e-01
Kinesins 47 2.01e-01 1.08e-01 4.42e-01
DCC mediated attractive signaling 13 5.03e-01 -1.07e-01 7.25e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 3.35e-01 -1.07e-01 5.89e-01
PRC2 methylates histones and DNA 20 4.07e-01 -1.07e-01 6.53e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 2.36e-01 -1.07e-01 4.76e-01
Signaling by RAS mutants 41 2.36e-01 -1.07e-01 4.76e-01
Signaling by moderate kinase activity BRAF mutants 41 2.36e-01 -1.07e-01 4.76e-01
Signaling downstream of RAS mutants 41 2.36e-01 -1.07e-01 4.76e-01
Amyloid fiber formation 42 2.31e-01 1.07e-01 4.75e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 5.41e-01 1.06e-01 7.48e-01
Acyl chain remodelling of PG 12 5.24e-01 1.06e-01 7.37e-01
Initiation of Nuclear Envelope (NE) Reformation 19 4.26e-01 -1.05e-01 6.68e-01
Pausing and recovery of Tat-mediated HIV elongation 30 3.18e-01 1.05e-01 5.70e-01
Tat-mediated HIV elongation arrest and recovery 30 3.18e-01 1.05e-01 5.70e-01
Platelet sensitization by LDL 17 4.52e-01 -1.05e-01 6.87e-01
RAB geranylgeranylation 53 1.85e-01 1.05e-01 4.26e-01
Negative regulation of FGFR2 signaling 25 3.64e-01 -1.05e-01 6.16e-01
Death Receptor Signaling 147 2.83e-02 1.05e-01 1.14e-01
Regulation of BACH1 activity 11 5.48e-01 -1.05e-01 7.54e-01
RAC3 GTPase cycle 87 9.23e-02 1.04e-01 2.86e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 4.57e-01 1.04e-01 6.89e-01
Tight junction interactions 17 4.57e-01 -1.04e-01 6.89e-01
Arachidonic acid metabolism 38 2.68e-01 1.04e-01 5.12e-01
RA biosynthesis pathway 15 4.87e-01 -1.04e-01 7.14e-01
Mitotic G1 phase and G1/S transition 141 3.41e-02 -1.03e-01 1.34e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 7.32e-02 1.03e-01 2.43e-01
Disease 1460 6.86e-11 1.03e-01 4.01e-09
Programmed Cell Death 188 1.50e-02 -1.03e-01 7.14e-02
SUMOylation of chromatin organization proteins 57 1.80e-01 1.03e-01 4.18e-01
Meiotic recombination 27 3.57e-01 1.02e-01 6.12e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 3.60e-01 -1.02e-01 6.13e-01
HDR through Homologous Recombination (HRR) 65 1.58e-01 1.01e-01 3.91e-01
Regulation of CDH11 function 10 5.80e-01 1.01e-01 7.77e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 24 3.92e-01 1.01e-01 6.40e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 24 3.92e-01 1.01e-01 6.40e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 24 3.92e-01 1.01e-01 6.40e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 24 3.92e-01 1.01e-01 6.40e-01
Signaling by NOTCH1 73 1.36e-01 -1.01e-01 3.60e-01
Mitotic Telophase/Cytokinesis 13 5.30e-01 1.01e-01 7.42e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 4.86e-01 1.01e-01 7.14e-01
SARS-CoV-2 modulates autophagy 11 5.64e-01 1.00e-01 7.67e-01
Transport of the SLBP Dependant Mature mRNA 36 2.98e-01 1.00e-01 5.46e-01
RHOA GTPase cycle 143 3.89e-02 1.00e-01 1.49e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.62e-01 1.00e-01 5.03e-01
Centrosome maturation 79 1.24e-01 1.00e-01 3.41e-01
Recruitment of mitotic centrosome proteins and complexes 79 1.24e-01 1.00e-01 3.41e-01
Intracellular signaling by second messengers 279 4.22e-03 -9.97e-02 2.60e-02
RHOC GTPase cycle 70 1.51e-01 9.94e-02 3.81e-01
RNA Polymerase III Transcription Initiation 36 3.02e-01 -9.94e-02 5.51e-01
Macroautophagy 124 5.71e-02 -9.90e-02 1.97e-01
Translesion synthesis by POLI 17 4.80e-01 9.90e-02 7.10e-01
HIV Transcription Initiation 45 2.51e-01 -9.90e-02 4.89e-01
RNA Polymerase II HIV Promoter Escape 45 2.51e-01 -9.90e-02 4.89e-01
RNA Polymerase II Promoter Escape 45 2.51e-01 -9.90e-02 4.89e-01
RNA Polymerase II Transcription Initiation 45 2.51e-01 -9.90e-02 4.89e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 2.51e-01 -9.90e-02 4.89e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 2.51e-01 -9.90e-02 4.89e-01
Processive synthesis on the C-strand of the telomere 19 4.56e-01 9.89e-02 6.88e-01
Interleukin-35 Signalling 10 5.89e-01 -9.87e-02 7.78e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 44 2.58e-01 -9.87e-02 4.98e-01
Rev-mediated nuclear export of HIV RNA 35 3.14e-01 9.83e-02 5.67e-01
Adherens junctions interactions 48 2.40e-01 9.81e-02 4.80e-01
DNA Double Strand Break Response 45 2.56e-01 -9.80e-02 4.96e-01
IRS-related events triggered by IGF1R 40 2.85e-01 -9.78e-02 5.31e-01
G1/S-Specific Transcription 24 4.07e-01 9.77e-02 6.53e-01
Semaphorin interactions 63 1.81e-01 9.76e-02 4.20e-01
Activated NOTCH1 Transmits Signal to the Nucleus 31 3.48e-01 -9.73e-02 6.05e-01
Amino acids regulate mTORC1 49 2.39e-01 9.72e-02 4.80e-01
Regulation of TP53 Activity through Association with Co-factors 11 5.77e-01 9.72e-02 7.76e-01
Signaling by SCF-KIT 39 2.94e-01 9.71e-02 5.41e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 9.40e-02 -9.70e-02 2.87e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.90e-01 9.70e-02 4.30e-01
Diseases of mitotic cell cycle 36 3.16e-01 9.66e-02 5.69e-01
Meiotic synapsis 32 3.44e-01 -9.66e-02 6.01e-01
Signaling by PDGFR in disease 20 4.55e-01 9.66e-02 6.88e-01
Protein-protein interactions at synapses 60 1.96e-01 9.65e-02 4.37e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 5.65e-01 9.59e-02 7.67e-01
Senescence-Associated Secretory Phenotype (SASP) 57 2.12e-01 9.55e-02 4.56e-01
SUMOylation of DNA damage response and repair proteins 77 1.48e-01 9.55e-02 3.77e-01
NGF-stimulated transcription 35 3.30e-01 9.51e-02 5.84e-01
PIP3 activates AKT signaling 243 1.09e-02 -9.50e-02 5.52e-02
Effects of PIP2 hydrolysis 23 4.31e-01 -9.49e-02 6.72e-01
Tie2 Signaling 16 5.12e-01 -9.48e-02 7.29e-01
Interleukin-20 family signaling 13 5.56e-01 9.44e-02 7.60e-01
C-type lectin receptors (CLRs) 122 7.35e-02 -9.39e-02 2.43e-01
Glucose metabolism 84 1.38e-01 9.36e-02 3.61e-01
Downregulation of TGF-beta receptor signaling 26 4.10e-01 -9.35e-02 6.53e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 34 3.47e-01 9.32e-02 6.04e-01
G0 and Early G1 24 4.31e-01 9.29e-02 6.72e-01
FCERI mediated MAPK activation 31 3.72e-01 9.27e-02 6.23e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 3.57e-01 9.26e-02 6.12e-01
RHO GTPase cycle 418 1.22e-03 9.25e-02 9.70e-03
Insulin receptor signalling cascade 42 3.01e-01 -9.24e-02 5.49e-01
Amino acid transport across the plasma membrane 24 4.35e-01 9.21e-02 6.72e-01
STING mediated induction of host immune responses 15 5.37e-01 9.21e-02 7.44e-01
Vasopressin regulates renal water homeostasis via Aquaporins 33 3.60e-01 -9.20e-02 6.13e-01
AURKA Activation by TPX2 69 1.87e-01 9.20e-02 4.26e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes 14 5.53e-01 -9.16e-02 7.58e-01
Cargo trafficking to the periciliary membrane 46 2.85e-01 9.11e-02 5.31e-01
Interleukin-6 family signaling 21 4.70e-01 9.11e-02 7.02e-01
Pyrimidine salvage 10 6.19e-01 9.09e-02 8.00e-01
Toll Like Receptor 9 (TLR9) Cascade 105 1.09e-01 -9.06e-02 3.11e-01
MyD88 dependent cascade initiated on endosome 101 1.16e-01 -9.05e-02 3.25e-01
SUMO E3 ligases SUMOylate target proteins 160 4.87e-02 9.04e-02 1.77e-01
S Phase 155 5.25e-02 -9.03e-02 1.88e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 72 1.85e-01 9.03e-02 4.26e-01
Translesion Synthesis by POLH 18 5.08e-01 -9.02e-02 7.26e-01
Regulation of IFNG signaling 13 5.74e-01 9.00e-02 7.74e-01
Generation of second messenger molecules 16 5.34e-01 8.98e-02 7.43e-01
Oncogenic MAPK signaling 76 1.76e-01 -8.98e-02 4.14e-01
PLC beta mediated events 45 2.98e-01 -8.98e-02 5.46e-01
Frs2-mediated activation 12 5.93e-01 -8.92e-02 7.78e-01
TNFR2 non-canonical NF-kB pathway 87 1.51e-01 -8.91e-02 3.81e-01
Voltage gated Potassium channels 20 4.91e-01 -8.89e-02 7.18e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 5.79e-01 8.88e-02 7.77e-01
Defective EXT2 causes exostoses 2 13 5.79e-01 8.88e-02 7.77e-01
Drug ADME 60 2.35e-01 8.87e-02 4.76e-01
Polymerase switching on the C-strand of the telomere 26 4.35e-01 8.85e-02 6.72e-01
Protein ubiquitination 64 2.21e-01 -8.84e-02 4.67e-01
Integration of energy metabolism 87 1.54e-01 -8.84e-02 3.86e-01
Loss of Nlp from mitotic centrosomes 67 2.15e-01 8.76e-02 4.58e-01
Loss of proteins required for interphase microtubule organization from the centrosome 67 2.15e-01 8.76e-02 4.58e-01
TICAM1-dependent activation of IRF3/IRF7 12 6.00e-01 8.75e-02 7.85e-01
Aquaporin-mediated transport 35 3.72e-01 -8.73e-02 6.23e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 31 4.03e-01 -8.68e-02 6.49e-01
GAB1 signalosome 13 5.88e-01 -8.67e-02 7.78e-01
Base-Excision Repair, AP Site Formation 23 4.72e-01 -8.66e-02 7.04e-01
Insulin receptor recycling 25 4.54e-01 8.66e-02 6.88e-01
Formation of Fibrin Clot (Clotting Cascade) 19 5.14e-01 -8.65e-02 7.30e-01
Hemostasis 476 1.30e-03 8.64e-02 1.02e-02
HDR through MMEJ (alt-NHEJ) 12 6.06e-01 8.59e-02 7.92e-01
Diseases of signal transduction by growth factor receptors and second messengers 393 3.61e-03 -8.58e-02 2.30e-02
IGF1R signaling cascade 41 3.42e-01 -8.58e-02 5.98e-01
Nuclear Pore Complex (NPC) Disassembly 36 3.75e-01 8.55e-02 6.25e-01
Signaling by FGFR2 IIIa TM 19 5.21e-01 -8.51e-02 7.36e-01
Metabolism of nucleotides 85 1.76e-01 8.50e-02 4.14e-01
EPHA-mediated growth cone collapse 23 4.81e-01 -8.48e-02 7.11e-01
HATs acetylate histones 84 1.80e-01 -8.47e-02 4.18e-01
Transport of the SLBP independent Mature mRNA 35 3.86e-01 8.47e-02 6.36e-01
IL-6-type cytokine receptor ligand interactions 14 5.85e-01 8.42e-02 7.78e-01
Autophagy 139 8.84e-02 -8.38e-02 2.78e-01
ALK mutants bind TKIs 11 6.31e-01 8.35e-02 8.07e-01
Signaling by FGFR1 40 3.62e-01 -8.33e-02 6.14e-01
Signaling by the B Cell Receptor (BCR) 104 1.42e-01 -8.33e-02 3.69e-01
MyD88-independent TLR4 cascade 107 1.37e-01 -8.33e-02 3.60e-01
TRIF(TICAM1)-mediated TLR4 signaling 107 1.37e-01 -8.33e-02 3.60e-01
RET signaling 32 4.15e-01 8.33e-02 6.59e-01
Nonhomologous End-Joining (NHEJ) 35 3.95e-01 -8.31e-02 6.40e-01
Phase I - Functionalization of compounds 65 2.49e-01 -8.28e-02 4.89e-01
Removal of the Flap Intermediate from the C-strand 17 5.59e-01 8.18e-02 7.63e-01
SUMOylation of SUMOylation proteins 35 4.04e-01 8.15e-02 6.51e-01
RHOBTB2 GTPase cycle 23 4.99e-01 -8.14e-02 7.23e-01
Constitutive Signaling by Overexpressed ERBB2 11 6.40e-01 8.14e-02 8.15e-01
Interferon gamma signaling 74 2.28e-01 8.10e-02 4.75e-01
Endogenous sterols 18 5.52e-01 8.09e-02 7.58e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 5.88e-01 8.09e-02 7.78e-01
Factors involved in megakaryocyte development and platelet production 116 1.34e-01 8.07e-02 3.56e-01
Miscellaneous transport and binding events 22 5.13e-01 -8.06e-02 7.30e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 6.15e-01 8.05e-02 7.99e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 1.61e-01 -8.05e-02 3.91e-01
Formation of TC-NER Pre-Incision Complex 53 3.11e-01 -8.04e-02 5.63e-01
Signaling by ERBB4 51 3.22e-01 -8.01e-02 5.73e-01
PCP/CE pathway 87 1.97e-01 -8.01e-02 4.37e-01
Intrinsic Pathway for Apoptosis 51 3.23e-01 -8.00e-02 5.74e-01
Antiviral mechanism by IFN-stimulated genes 79 2.19e-01 -8.00e-02 4.64e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 11 6.46e-01 7.99e-02 8.18e-01
DNA Damage Recognition in GG-NER 38 3.95e-01 -7.98e-02 6.40e-01
RHO GTPases Activate Formins 124 1.26e-01 7.97e-02 3.43e-01
Signaling by Rho GTPases 597 9.60e-04 7.95e-02 7.85e-03
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 612 8.43e-04 7.94e-02 7.13e-03
Fatty acid metabolism 144 1.01e-01 -7.92e-02 2.99e-01
Apoptotic execution phase 43 3.72e-01 -7.87e-02 6.23e-01
Signaling by BRAF and RAF1 fusions 60 2.92e-01 -7.86e-02 5.40e-01
Signaling by RAF1 mutants 37 4.08e-01 -7.86e-02 6.53e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 5.26e-01 -7.81e-02 7.39e-01
G-protein mediated events 49 3.47e-01 -7.77e-02 6.04e-01
Signaling by WNT 241 3.81e-02 -7.77e-02 1.47e-01
O-linked glycosylation of mucins 42 3.86e-01 7.73e-02 6.36e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 42 3.88e-01 -7.70e-02 6.38e-01
Cytoprotection by HMOX1 58 3.11e-01 -7.69e-02 5.63e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 3.16e-01 -7.68e-02 5.69e-01
SUMOylation of ubiquitinylation proteins 39 4.08e-01 7.66e-02 6.53e-01
Signaling by Retinoic Acid 35 4.35e-01 -7.63e-02 6.72e-01
Diseases of programmed cell death 48 3.61e-01 7.62e-02 6.14e-01
Downstream signal transduction 28 4.86e-01 7.61e-02 7.14e-01
Transcriptional regulation by RUNX1 163 9.73e-02 -7.53e-02 2.91e-01
Cell Cycle Checkpoints 237 4.62e-02 -7.53e-02 1.70e-01
Cellular response to chemical stress 183 8.05e-02 -7.50e-02 2.58e-01
ISG15 antiviral mechanism 71 2.75e-01 -7.49e-02 5.19e-01
Signaling by cytosolic FGFR1 fusion mutants 18 5.83e-01 7.47e-02 7.78e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 4.94e-01 -7.47e-02 7.20e-01
Mitotic Prometaphase 186 8.01e-02 7.45e-02 2.58e-01
Telomere C-strand (Lagging Strand) Synthesis 34 4.52e-01 7.45e-02 6.87e-01
N-Glycan antennae elongation 13 6.42e-01 7.45e-02 8.16e-01
Transmission across Chemical Synapses 184 8.20e-02 -7.45e-02 2.61e-01
Early Phase of HIV Life Cycle 14 6.32e-01 7.40e-02 8.07e-01
Cell-extracellular matrix interactions 18 5.87e-01 -7.40e-02 7.78e-01
SUMOylation 166 1.01e-01 7.39e-02 2.99e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 6.20e-01 7.39e-02 8.02e-01
Axon guidance 487 5.84e-03 7.32e-02 3.33e-02
Neurotransmitter receptors and postsynaptic signal transmission 139 1.38e-01 -7.30e-02 3.60e-01
Diseases of carbohydrate metabolism 29 4.97e-01 7.29e-02 7.22e-01
Sensory processing of sound 51 3.69e-01 7.28e-02 6.21e-01
Separation of Sister Chromatids 173 9.91e-02 -7.28e-02 2.95e-01
Paracetamol ADME 19 5.84e-01 7.26e-02 7.78e-01
Recognition of DNA damage by PCNA-containing replication complex 29 5.00e-01 -7.24e-02 7.23e-01
Signaling by Erythropoietin 24 5.39e-01 7.24e-02 7.46e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 1.96e-01 -7.21e-02 4.37e-01
Toll Like Receptor 2 (TLR2) Cascade 108 1.96e-01 -7.21e-02 4.37e-01
Toll Like Receptor TLR1:TLR2 Cascade 108 1.96e-01 -7.21e-02 4.37e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 1.96e-01 -7.21e-02 4.37e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 82 2.60e-01 -7.21e-02 5.00e-01
ZBP1(DAI) mediated induction of type I IFNs 19 5.87e-01 7.19e-02 7.78e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 5.54e-01 7.13e-02 7.59e-01
PI3K Cascade 33 4.79e-01 -7.12e-02 7.09e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 4.89e-01 7.06e-02 7.15e-01
SHC1 events in ERBB2 signaling 20 5.85e-01 -7.05e-02 7.78e-01
Platelet Aggregation (Plug Formation) 30 5.04e-01 7.05e-02 7.25e-01
p130Cas linkage to MAPK signaling for integrins 12 6.73e-01 7.03e-02 8.43e-01
Fatty acyl-CoA biosynthesis 31 4.98e-01 -7.03e-02 7.23e-01
Acyl chain remodelling of PC 20 5.87e-01 7.02e-02 7.78e-01
NRIF signals cell death from the nucleus 16 6.28e-01 7.00e-02 8.06e-01
PERK regulates gene expression 31 5.01e-01 6.98e-02 7.24e-01
E3 ubiquitin ligases ubiquitinate target proteins 44 4.24e-01 -6.97e-02 6.66e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 5.31e-01 -6.96e-02 7.42e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 5.31e-01 -6.96e-02 7.42e-01
Disorders of Developmental Biology 12 6.79e-01 6.90e-02 8.44e-01
Disorders of Nervous System Development 12 6.79e-01 6.90e-02 8.44e-01
Loss of function of MECP2 in Rett syndrome 12 6.79e-01 6.90e-02 8.44e-01
Pervasive developmental disorders 12 6.79e-01 6.90e-02 8.44e-01
RND2 GTPase cycle 36 4.74e-01 6.90e-02 7.05e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 5.93e-01 6.90e-02 7.78e-01
Regulation of HSF1-mediated heat shock response 79 2.93e-01 -6.85e-02 5.40e-01
Non-integrin membrane-ECM interactions 55 3.85e-01 6.78e-02 6.35e-01
SLBP independent Processing of Histone Pre-mRNAs 10 7.11e-01 -6.76e-02 8.66e-01
Phospholipid metabolism 181 1.18e-01 6.75e-02 3.29e-01
RAS processing 22 5.87e-01 -6.69e-02 7.78e-01
Regulation of PTEN gene transcription 60 3.70e-01 6.69e-02 6.23e-01
Translesion synthesis by REV1 16 6.44e-01 6.67e-02 8.17e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.14e-01 6.66e-02 7.30e-01
Gluconeogenesis 29 5.35e-01 6.66e-02 7.43e-01
Extension of Telomeres 49 4.21e-01 6.65e-02 6.65e-01
Class I MHC mediated antigen processing & presentation 354 3.22e-02 -6.65e-02 1.28e-01
NCAM1 interactions 31 5.24e-01 -6.62e-02 7.37e-01
Glucagon-type ligand receptors 18 6.27e-01 6.62e-02 8.06e-01
Nervous system development 507 1.11e-02 6.61e-02 5.60e-02
Signaling by EGFR in Cancer 21 6.01e-01 -6.59e-02 7.86e-01
RNA Polymerase I Promoter Escape 38 4.84e-01 -6.56e-02 7.12e-01
HS-GAG biosynthesis 22 5.96e-01 6.53e-02 7.81e-01
Sensory processing of sound by outer hair cells of the cochlea 37 4.92e-01 6.53e-02 7.18e-01
HDR through Single Strand Annealing (SSA) 35 5.06e-01 6.50e-02 7.25e-01
SHC-mediated cascade:FGFR2 14 6.74e-01 -6.50e-02 8.43e-01
Homologous DNA Pairing and Strand Exchange 41 4.73e-01 6.49e-02 7.04e-01
Cytosolic sensors of pathogen-associated DNA 62 3.78e-01 6.48e-02 6.27e-01
ER-Phagosome pathway 79 3.20e-01 -6.47e-02 5.71e-01
Signaling by Hippo 19 6.26e-01 -6.47e-02 8.06e-01
Insulin processing 20 6.18e-01 6.45e-02 8.00e-01
Regulation of NPAS4 gene expression 12 6.99e-01 -6.44e-02 8.60e-01
Regulation of gene expression by Hypoxia-inducible Factor 10 7.24e-01 6.44e-02 8.75e-01
Transcriptional regulation by RUNX2 112 2.40e-01 -6.43e-02 4.80e-01
Impaired BRCA2 binding to RAD51 33 5.23e-01 6.43e-02 7.37e-01
Signaling by Interleukins 377 3.35e-02 6.40e-02 1.32e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 6.59e-01 6.38e-02 8.30e-01
Josephin domain DUBs 10 7.27e-01 -6.37e-02 8.77e-01
RHO GTPases activate KTN1 10 7.28e-01 6.36e-02 8.77e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 28 5.62e-01 6.33e-02 7.65e-01
Cellular responses to stimuli 699 4.58e-03 6.33e-02 2.77e-02
Norepinephrine Neurotransmitter Release Cycle 13 6.93e-01 -6.31e-02 8.56e-01
VEGFR2 mediated vascular permeability 27 5.71e-01 6.31e-02 7.70e-01
Presynaptic phase of homologous DNA pairing and strand exchange 38 5.03e-01 6.28e-02 7.25e-01
Signaling by CSF3 (G-CSF) 30 5.52e-01 6.28e-02 7.58e-01
RORA activates gene expression 18 6.45e-01 6.27e-02 8.17e-01
mRNA Splicing - Minor Pathway 50 4.44e-01 6.26e-02 6.81e-01
Diseases associated with O-glycosylation of proteins 56 4.18e-01 6.26e-02 6.62e-01
Repression of WNT target genes 14 6.85e-01 -6.25e-02 8.48e-01
Nucleotide-like (purinergic) receptors 14 6.86e-01 -6.25e-02 8.48e-01
FCGR3A-mediated IL10 synthesis 34 5.29e-01 6.24e-02 7.41e-01
Adrenaline,noradrenaline inhibits insulin secretion 22 6.13e-01 6.23e-02 7.99e-01
Synthesis of bile acids and bile salts 24 5.98e-01 -6.22e-02 7.83e-01
Assembly and cell surface presentation of NMDA receptors 31 5.53e-01 -6.16e-02 7.58e-01
Maturation of nucleoprotein 9694631 15 6.81e-01 6.14e-02 8.46e-01
Regulation of MECP2 expression and activity 29 5.68e-01 -6.13e-02 7.69e-01
IKK complex recruitment mediated by RIP1 23 6.11e-01 6.13e-02 7.97e-01
p75NTR signals via NF-kB 16 6.71e-01 6.13e-02 8.42e-01
Synthesis of PIPs at the early endosome membrane 16 6.72e-01 6.12e-02 8.42e-01
Inositol phosphate metabolism 43 4.88e-01 -6.12e-02 7.14e-01
Signaling by Hedgehog 139 2.17e-01 -6.07e-02 4.60e-01
Cell-cell junction organization 67 3.91e-01 6.07e-02 6.40e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 63 4.06e-01 -6.06e-02 6.52e-01
Cytokine Signaling in Immune system 580 1.39e-02 6.01e-02 6.71e-02
Positive epigenetic regulation of rRNA expression 53 4.50e-01 6.00e-02 6.86e-01
RNA polymerase II transcribes snRNA genes 71 3.84e-01 -5.98e-02 6.34e-01
Beta-oxidation of very long chain fatty acids 10 7.43e-01 -5.98e-02 8.86e-01
Mitotic Anaphase 216 1.31e-01 -5.97e-02 3.52e-01
MET activates RAP1 and RAC1 11 7.32e-01 -5.96e-02 8.79e-01
PKMTs methylate histone lysines 42 5.04e-01 5.96e-02 7.25e-01
Interleukin-15 signaling 13 7.10e-01 5.95e-02 8.66e-01
Deactivation of the beta-catenin transactivating complex 39 5.22e-01 -5.93e-02 7.36e-01
Cellular responses to stress 691 8.26e-03 5.93e-02 4.51e-02
IRS-mediated signalling 37 5.33e-01 -5.92e-02 7.43e-01
Mitotic Metaphase and Anaphase 217 1.34e-01 -5.91e-02 3.56e-01
Regulation of TP53 Activity through Phosphorylation 87 3.41e-01 -5.91e-02 5.98e-01
Purine catabolism 15 6.92e-01 5.90e-02 8.55e-01
Biotin transport and metabolism 11 7.35e-01 5.89e-02 8.79e-01
Peptide hormone metabolism 54 4.55e-01 5.87e-02 6.88e-01
Formation of RNA Pol II elongation complex 56 4.49e-01 5.85e-02 6.85e-01
RNA Polymerase II Transcription Elongation 56 4.49e-01 5.85e-02 6.85e-01
Early SARS-CoV-2 Infection Events 32 5.67e-01 -5.85e-02 7.68e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 6.14e-01 -5.83e-02 7.99e-01
mRNA Capping 29 5.88e-01 -5.82e-02 7.78e-01
TNFR1-induced proapoptotic signaling 25 6.16e-01 5.80e-02 7.99e-01
Processing of Capped Intron-Containing Pre-mRNA 278 9.69e-02 5.80e-02 2.90e-01
Cytochrome P450 - arranged by substrate type 32 5.71e-01 5.80e-02 7.70e-01
Downregulation of ERBB2:ERBB3 signaling 13 7.18e-01 -5.78e-02 8.71e-01
Signaling by Non-Receptor Tyrosine Kinases 50 4.83e-01 5.74e-02 7.11e-01
Signaling by PTK6 50 4.83e-01 5.74e-02 7.11e-01
Neuronal System 261 1.14e-01 -5.69e-02 3.21e-01
Clathrin-mediated endocytosis 127 2.70e-01 5.68e-02 5.13e-01
Signal transduction by L1 21 6.53e-01 -5.67e-02 8.24e-01
Mitotic Prophase 89 3.57e-01 5.65e-02 6.12e-01
Chromatin modifying enzymes 204 1.67e-01 5.62e-02 3.99e-01
Chromatin organization 204 1.67e-01 5.62e-02 3.99e-01
PI3K/AKT Signaling in Cancer 84 3.74e-01 -5.61e-02 6.25e-01
SHC-mediated cascade:FGFR1 13 7.27e-01 -5.60e-02 8.77e-01
Adaptive Immune System 649 1.57e-02 5.59e-02 7.37e-02
FOXO-mediated transcription 56 4.71e-01 -5.57e-02 7.03e-01
FOXO-mediated transcription of cell death genes 15 7.10e-01 -5.55e-02 8.66e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 23 6.45e-01 5.55e-02 8.17e-01
Nuclear Events (kinase and transcription factor activation) 57 4.69e-01 -5.55e-02 7.02e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 7.50e-01 -5.54e-02 8.89e-01
Signaling by EGFR 44 5.27e-01 -5.51e-02 7.40e-01
G alpha (i) signalling events 177 2.07e-01 5.51e-02 4.48e-01
Post-translational modification: synthesis of GPI-anchored proteins 58 4.75e-01 5.43e-02 7.06e-01
Activated NTRK2 signals through FRS2 and FRS3 10 7.69e-01 -5.37e-02 8.99e-01
Estrogen-dependent gene expression 91 3.80e-01 -5.33e-02 6.30e-01
G alpha (z) signalling events 37 5.76e-01 5.32e-02 7.76e-01
Nicotinate metabolism 28 6.27e-01 5.30e-02 8.06e-01
Signaling by Receptor Tyrosine Kinases 468 5.25e-02 5.25e-02 1.88e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 5.47e-01 5.25e-02 7.54e-01
Metabolism of steroid hormones 20 6.85e-01 5.24e-02 8.48e-01
Termination of O-glycan biosynthesis 14 7.39e-01 -5.14e-02 8.82e-01
G2/M Transition 183 2.32e-01 -5.13e-02 4.75e-01
L1CAM interactions 101 3.75e-01 5.11e-02 6.25e-01
Regulation of PTEN mRNA translation 11 7.69e-01 5.11e-02 8.99e-01
Signaling by FGFR 72 4.54e-01 -5.10e-02 6.88e-01
Mitotic G2-G2/M phases 185 2.33e-01 -5.09e-02 4.76e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 39 5.83e-01 5.08e-02 7.78e-01
Diseases of DNA Double-Strand Break Repair 39 5.83e-01 5.08e-02 7.78e-01
CD209 (DC-SIGN) signaling 20 6.95e-01 5.06e-02 8.57e-01
Export of Viral Ribonucleoproteins from Nucleus 33 6.18e-01 5.02e-02 8.00e-01
COPI-independent Golgi-to-ER retrograde traffic 44 5.65e-01 5.01e-02 7.67e-01
RHOJ GTPase cycle 53 5.29e-01 5.00e-02 7.41e-01
ESR-mediated signaling 151 2.93e-01 -4.97e-02 5.40e-01
Assembly Of The HIV Virion 16 7.34e-01 4.91e-02 8.79e-01
CTLA4 inhibitory signaling 18 7.21e-01 4.87e-02 8.72e-01
Bile acid and bile salt metabolism 27 6.62e-01 -4.86e-02 8.33e-01
AKT phosphorylates targets in the cytosol 14 7.53e-01 4.86e-02 8.90e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 7.80e-01 -4.86e-02 9.07e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 7.30e-01 -4.83e-02 8.78e-01
HCMV Early Events 76 4.69e-01 4.80e-02 7.02e-01
Signaling by TGF-beta Receptor Complex 92 4.28e-01 4.78e-02 6.71e-01
Opioid Signalling 78 4.67e-01 -4.77e-02 7.00e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 5.93e-01 4.77e-02 7.78e-01
HIV Transcription Elongation 42 5.93e-01 4.77e-02 7.78e-01
Tat-mediated elongation of the HIV-1 transcript 42 5.93e-01 4.77e-02 7.78e-01
Ion channel transport 137 3.36e-01 -4.76e-02 5.91e-01
Signaling by FGFR in disease 54 5.46e-01 -4.76e-02 7.53e-01
Uptake and function of anthrax toxins 11 7.85e-01 -4.74e-02 9.09e-01
Activation of the pre-replicative complex 29 6.59e-01 -4.74e-02 8.30e-01
Base Excision Repair 51 5.59e-01 -4.73e-02 7.63e-01
RNA Polymerase I Transcription Initiation 47 5.81e-01 4.66e-02 7.78e-01
Regulation of beta-cell development 20 7.20e-01 -4.63e-02 8.72e-01
TGF-beta receptor signaling activates SMADs 46 5.87e-01 4.63e-02 7.78e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 7.34e-01 4.62e-02 8.79e-01
Neurodegenerative Diseases 18 7.34e-01 4.62e-02 8.79e-01
Beta-catenin independent WNT signaling 132 3.60e-01 -4.62e-02 6.13e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 7.57e-01 4.61e-02 8.92e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 7.17e-01 4.57e-02 8.71e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 7.17e-01 4.57e-02 8.71e-01
Activation of BH3-only proteins 27 6.82e-01 -4.55e-02 8.48e-01
RHOV GTPase cycle 34 6.48e-01 -4.53e-02 8.18e-01
RIPK1-mediated regulated necrosis 30 6.68e-01 4.52e-02 8.39e-01
Regulation of necroptotic cell death 30 6.68e-01 4.52e-02 8.39e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 95 4.49e-01 4.50e-02 6.85e-01
Acetylcholine Neurotransmitter Release Cycle 11 7.98e-01 4.47e-02 9.15e-01
G2/M DNA damage checkpoint 57 5.61e-01 -4.45e-02 7.64e-01
NF-kB is activated and signals survival 13 7.82e-01 -4.42e-02 9.08e-01
RHOG GTPase cycle 71 5.22e-01 4.40e-02 7.36e-01
Metabolism of RNA 695 5.23e-02 4.34e-02 1.87e-01
Host Interactions of HIV factors 124 4.06e-01 -4.33e-02 6.52e-01
Negative regulation of the PI3K/AKT network 89 4.82e-01 -4.32e-02 7.11e-01
Formation of WDR5-containing histone-modifying complexes 42 6.31e-01 -4.29e-02 8.07e-01
Vitamin B5 (pantothenate) metabolism 16 7.67e-01 4.29e-02 8.99e-01
Epigenetic regulation of gene expression 133 3.95e-01 4.28e-02 6.40e-01
Signaling by FGFR2 61 5.67e-01 -4.24e-02 7.68e-01
Advanced glycosylation endproduct receptor signaling 12 8.01e-01 4.20e-02 9.15e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 31 6.86e-01 -4.20e-02 8.48e-01
O-linked glycosylation 87 5.00e-01 4.19e-02 7.23e-01
Regulation of localization of FOXO transcription factors 11 8.11e-01 4.17e-02 9.17e-01
Circadian Clock 66 5.59e-01 4.16e-02 7.63e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 22 7.37e-01 -4.13e-02 8.81e-01
mRNA Splicing - Major Pathway 202 3.16e-01 4.10e-02 5.69e-01
FGFR2 alternative splicing 24 7.29e-01 4.09e-02 8.77e-01
TRP channels 20 7.53e-01 4.07e-02 8.90e-01
Neurotransmitter release cycle 35 6.78e-01 -4.05e-02 8.44e-01
Ovarian tumor domain proteases 36 6.74e-01 4.05e-02 8.43e-01
Post-translational protein modification 1194 1.97e-02 4.04e-02 8.59e-02
Glucagon signaling in metabolic regulation 25 7.28e-01 -4.02e-02 8.77e-01
Defective Intrinsic Pathway for Apoptosis 21 7.51e-01 4.01e-02 8.89e-01
Homology Directed Repair 101 4.88e-01 4.00e-02 7.14e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 7.25e-01 3.99e-02 8.75e-01
mRNA Splicing 210 3.20e-01 3.99e-02 5.71e-01
Methylation 12 8.11e-01 3.98e-02 9.17e-01
Cargo recognition for clathrin-mediated endocytosis 88 5.19e-01 3.98e-02 7.34e-01
DNA Damage Bypass 45 6.45e-01 -3.97e-02 8.17e-01
Aggrephagy 33 6.94e-01 -3.96e-02 8.56e-01
Pre-NOTCH Expression and Processing 56 6.14e-01 3.89e-02 7.99e-01
Translesion synthesis by POLK 17 7.81e-01 3.89e-02 9.07e-01
HCMV Infection 99 5.05e-01 3.88e-02 7.25e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 7.39e-01 3.85e-02 8.82e-01
Defective pyroptosis 20 7.66e-01 -3.84e-02 8.99e-01
Synthesis of IP3 and IP4 in the cytosol 23 7.54e-01 -3.78e-02 8.90e-01
Oxidative Stress Induced Senescence 69 5.88e-01 -3.77e-02 7.78e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 6.29e-01 3.77e-02 8.07e-01
tRNA processing in the nucleus 59 6.22e-01 3.71e-02 8.03e-01
Acyl chain remodelling of PI 11 8.32e-01 3.71e-02 9.25e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 8.04e-01 3.70e-02 9.15e-01
Signaling by NTRK2 (TRKB) 23 7.60e-01 -3.67e-02 8.94e-01
Constitutive Signaling by EGFRvIII 15 8.06e-01 -3.67e-02 9.15e-01
Signaling by EGFRvIII in Cancer 15 8.06e-01 -3.67e-02 9.15e-01
RND1 GTPase cycle 36 7.06e-01 -3.63e-02 8.64e-01
GPCR downstream signalling 368 2.33e-01 3.63e-02 4.76e-01
Inactivation, recovery and regulation of the phototransduction cascade 19 7.84e-01 -3.63e-02 9.09e-01
Metabolism of steroids 118 4.97e-01 3.62e-02 7.22e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 7.96e-01 -3.61e-02 9.15e-01
Formation of the beta-catenin:TCF transactivating complex 37 7.07e-01 -3.57e-02 8.65e-01
EML4 and NUDC in mitotic spindle formation 101 5.36e-01 3.57e-02 7.44e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 8.45e-01 3.56e-02 9.33e-01
Apoptotic cleavage of cellular proteins 35 7.19e-01 -3.51e-02 8.72e-01
Disorders of transmembrane transporters 138 4.78e-01 -3.50e-02 7.09e-01
Activation of HOX genes during differentiation 66 6.24e-01 -3.49e-02 8.05e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 66 6.24e-01 -3.49e-02 8.05e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 7.94e-01 -3.47e-02 9.15e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 7.94e-01 -3.47e-02 9.15e-01
G alpha (q) signalling events 129 4.97e-01 3.47e-02 7.22e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 23 7.75e-01 3.44e-02 9.03e-01
Signaling by ERBB2 47 6.84e-01 -3.43e-02 8.48e-01
Formation of Incision Complex in GG-NER 43 6.97e-01 -3.43e-02 8.59e-01
AKT phosphorylates targets in the nucleus 10 8.51e-01 3.42e-02 9.37e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 8.38e-01 -3.42e-02 9.28e-01
APC-Cdc20 mediated degradation of Nek2A 25 7.68e-01 3.41e-02 8.99e-01
p75NTR recruits signalling complexes 13 8.32e-01 3.40e-02 9.25e-01
Prolonged ERK activation events 14 8.27e-01 -3.37e-02 9.24e-01
Antigen processing-Cross presentation 92 5.77e-01 3.37e-02 7.76e-01
RUNX3 regulates NOTCH signaling 14 8.28e-01 -3.35e-02 9.24e-01
Termination of translesion DNA synthesis 31 7.47e-01 3.35e-02 8.89e-01
Nuclear signaling by ERBB4 29 7.57e-01 -3.32e-02 8.92e-01
Phase II - Conjugation of compounds 68 6.37e-01 3.31e-02 8.12e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 8.20e-01 3.28e-02 9.20e-01
Regulation of PLK1 Activity at G2/M Transition 85 6.07e-01 3.23e-02 7.92e-01
NPAS4 regulates expression of target genes 19 8.08e-01 3.23e-02 9.17e-01
Interferon Signaling 166 4.76e-01 3.21e-02 7.06e-01
Activation of ATR in response to replication stress 31 7.58e-01 -3.20e-02 8.93e-01
HIV Life Cycle 145 5.06e-01 3.20e-02 7.25e-01
Regulation of TP53 Activity 151 4.99e-01 -3.19e-02 7.23e-01
Processing of Intronless Pre-mRNAs 20 8.06e-01 3.18e-02 9.15e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 7.80e-01 -3.17e-02 9.07e-01
NCAM signaling for neurite out-growth 51 6.99e-01 -3.13e-02 8.60e-01
Diseases of DNA repair 48 7.08e-01 3.13e-02 8.65e-01
Late Phase of HIV Life Cycle 132 5.37e-01 3.11e-02 7.44e-01
Gap junction assembly 19 8.15e-01 -3.10e-02 9.17e-01
Signaling by Nuclear Receptors 211 4.43e-01 -3.07e-02 6.79e-01
Meiosis 51 7.06e-01 3.06e-02 8.64e-01
MicroRNA (miRNA) biogenesis 25 7.92e-01 -3.05e-02 9.15e-01
Nucleotide salvage 22 8.05e-01 3.03e-02 9.15e-01
Toll-like Receptor Cascades 156 5.14e-01 3.03e-02 7.30e-01
Free fatty acids regulate insulin secretion 10 8.68e-01 -3.03e-02 9.47e-01
Activation of GABAB receptors 30 7.75e-01 3.01e-02 9.03e-01
GABA B receptor activation 30 7.75e-01 3.01e-02 9.03e-01
Metabolism of proteins 1633 4.93e-02 2.96e-02 1.79e-01
Resolution of Sister Chromatid Cohesion 110 5.92e-01 2.96e-02 7.78e-01
Cholesterol biosynthesis 27 7.92e-01 -2.93e-02 9.15e-01
VxPx cargo-targeting to cilium 17 8.34e-01 -2.93e-02 9.26e-01
Chaperone Mediated Autophagy 20 8.22e-01 2.90e-02 9.20e-01
rRNA modification in the nucleus and cytosol 59 7.03e-01 -2.87e-02 8.63e-01
Acyl chain remodelling of PE 21 8.21e-01 -2.86e-02 9.20e-01
Glycerophospholipid biosynthesis 104 6.19e-01 2.83e-02 8.00e-01
Interactions of Vpr with host cellular proteins 37 7.68e-01 2.80e-02 8.99e-01
SHC1 events in EGFR signaling 10 8.79e-01 -2.79e-02 9.49e-01
Signaling by high-kinase activity BRAF mutants 32 7.87e-01 2.76e-02 9.10e-01
Interleukin-6 signaling 11 8.77e-01 -2.70e-02 9.49e-01
Signaling by GPCR 410 3.51e-01 2.69e-02 6.08e-01
Processing of DNA double-strand break ends 61 7.17e-01 -2.68e-02 8.71e-01
Toll Like Receptor 4 (TLR4) Cascade 136 5.91e-01 -2.67e-02 7.78e-01
Budding and maturation of HIV virion 27 8.10e-01 -2.67e-02 9.17e-01
Deadenylation-dependent mRNA decay 50 7.48e-01 -2.63e-02 8.89e-01
Uptake and actions of bacterial toxins 24 8.26e-01 2.60e-02 9.23e-01
Physiological factors 10 8.87e-01 -2.60e-02 9.53e-01
Stimuli-sensing channels 76 7.00e-01 -2.56e-02 8.60e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.39e-01 -2.56e-02 9.28e-01
TNFR1-induced NF-kappa-B signaling pathway 33 8.00e-01 2.55e-02 9.15e-01
Notch-HLH transcription pathway 28 8.16e-01 -2.54e-02 9.17e-01
Metabolism of water-soluble vitamins and cofactors 110 6.51e-01 2.50e-02 8.21e-01
Signaling by NTRKs 125 6.30e-01 2.50e-02 8.07e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 8.81e-01 -2.50e-02 9.50e-01
Alpha-protein kinase 1 signaling pathway 11 8.86e-01 2.49e-02 9.53e-01
Synthesis of PA 31 8.12e-01 2.48e-02 9.17e-01
Regulation of TP53 Degradation 35 8.00e-01 -2.47e-02 9.15e-01
ADORA2B mediated anti-inflammatory cytokines production 34 8.04e-01 2.46e-02 9.15e-01
Carboxyterminal post-translational modifications of tubulin 30 8.16e-01 2.45e-02 9.17e-01
Eicosanoid ligand-binding receptors 13 8.78e-01 -2.45e-02 9.49e-01
RND3 GTPase cycle 36 8.01e-01 2.43e-02 9.15e-01
RHOQ GTPase cycle 57 7.51e-01 -2.43e-02 8.89e-01
RNA Polymerase II Pre-transcription Events 77 7.17e-01 2.39e-02 8.71e-01
Signaling by KIT in disease 19 8.57e-01 2.39e-02 9.40e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 8.57e-01 2.39e-02 9.40e-01
Regulation of TP53 Activity through Methylation 19 8.57e-01 2.39e-02 9.40e-01
Vpr-mediated nuclear import of PICs 34 8.11e-01 2.37e-02 9.17e-01
Cellular Senescence 131 6.41e-01 2.36e-02 8.16e-01
Nephrin family interactions 19 8.61e-01 -2.32e-02 9.42e-01
G alpha (s) signalling events 89 7.10e-01 2.28e-02 8.66e-01
Ephrin signaling 19 8.63e-01 -2.28e-02 9.43e-01
Heme signaling 44 7.94e-01 2.27e-02 9.15e-01
Purine salvage 13 8.91e-01 -2.20e-02 9.54e-01
Retinoid metabolism and transport 29 8.39e-01 -2.18e-02 9.28e-01
Glutamate and glutamine metabolism 11 9.02e-01 2.15e-02 9.59e-01
Receptor Mediated Mitophagy 11 9.02e-01 2.15e-02 9.59e-01
BBSome-mediated cargo-targeting to cilium 22 8.62e-01 2.14e-02 9.42e-01
Spry regulation of FGF signaling 16 8.83e-01 -2.13e-02 9.50e-01
Organelle biogenesis and maintenance 272 5.47e-01 2.12e-02 7.54e-01
Metabolism of lipids 609 3.74e-01 2.12e-02 6.25e-01
Activation of gene expression by SREBF (SREBP) 42 8.13e-01 -2.11e-02 9.17e-01
Metabolism of vitamins and cofactors 158 6.48e-01 -2.11e-02 8.18e-01
Regulation of NF-kappa B signaling 18 8.77e-01 -2.11e-02 9.49e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 7.49e-01 -2.09e-02 8.89e-01
Post-chaperonin tubulin folding pathway 17 8.82e-01 2.08e-02 9.50e-01
Postmitotic nuclear pore complex (NPC) reformation 27 8.52e-01 2.07e-02 9.38e-01
Regulated Necrosis 52 7.97e-01 2.07e-02 9.15e-01
Transcriptional regulation of white adipocyte differentiation 83 7.48e-01 2.04e-02 8.89e-01
Metabolism of porphyrins 20 8.75e-01 -2.03e-02 9.49e-01
Serotonin Neurotransmitter Release Cycle 13 8.99e-01 -2.02e-02 9.58e-01
Viral Messenger RNA Synthesis 44 8.17e-01 2.02e-02 9.17e-01
Regulation of TP53 Expression and Degradation 36 8.34e-01 -2.02e-02 9.26e-01
Nuclear Envelope (NE) Reassembly 67 7.76e-01 -2.01e-02 9.03e-01
Transcriptional regulation of granulopoiesis 34 8.39e-01 2.01e-02 9.28e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 29 8.51e-01 -2.01e-02 9.37e-01
tRNA Aminoacylation 42 8.22e-01 2.01e-02 9.20e-01
Deposition of new CENPA-containing nucleosomes at the centromere 31 8.47e-01 -2.01e-02 9.33e-01
Nucleosome assembly 31 8.47e-01 -2.01e-02 9.33e-01
NOD1/2 Signaling Pathway 36 8.35e-01 -2.01e-02 9.26e-01
Regulation of FOXO transcriptional activity by acetylation 10 9.14e-01 -1.98e-02 9.67e-01
Formation of the cornified envelope 23 8.70e-01 1.97e-02 9.48e-01
Keratinization 23 8.70e-01 1.97e-02 9.48e-01
Transcription of the HIV genome 67 7.81e-01 1.97e-02 9.07e-01
Cell junction organization 92 7.50e-01 -1.92e-02 8.89e-01
Visual phototransduction 58 8.01e-01 1.92e-02 9.15e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 86 7.61e-01 1.90e-02 8.94e-01
Amplification of signal from the kinetochores 86 7.61e-01 1.90e-02 8.94e-01
Cell Cycle, Mitotic 476 4.82e-01 1.89e-02 7.11e-01
Dual Incision in GG-NER 41 8.35e-01 1.89e-02 9.26e-01
Establishment of Sister Chromatid Cohesion 10 9.19e-01 -1.87e-02 9.69e-01
Metabolism of non-coding RNA 53 8.15e-01 1.86e-02 9.17e-01
snRNP Assembly 53 8.15e-01 1.86e-02 9.17e-01
Signaling by NTRK1 (TRKA) 108 7.41e-01 1.84e-02 8.83e-01
Synthesis of PC 23 8.79e-01 1.83e-02 9.50e-01
Cell-Cell communication 121 7.34e-01 1.79e-02 8.79e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 25 8.79e-01 -1.76e-02 9.49e-01
Trafficking of AMPA receptors 25 8.79e-01 -1.76e-02 9.49e-01
Activation of BAD and translocation to mitochondria 14 9.12e-01 1.71e-02 9.65e-01
TNF signaling 57 8.27e-01 1.68e-02 9.24e-01
MAP2K and MAPK activation 36 8.62e-01 1.68e-02 9.42e-01
Metabolic disorders of biological oxidation enzymes 22 8.92e-01 1.67e-02 9.54e-01
Regulation of lipid metabolism by PPARalpha 108 7.64e-01 1.67e-02 8.97e-01
GABA receptor activation 37 8.61e-01 1.66e-02 9.42e-01
Translation 292 6.33e-01 1.63e-02 8.08e-01
HIV Infection 220 6.79e-01 -1.62e-02 8.44e-01
Telomere Extension By Telomerase 21 8.98e-01 1.61e-02 9.58e-01
Generic Transcription Pathway 1078 3.83e-01 -1.59e-02 6.33e-01
TRAF6 mediated NF-kB activation 23 8.95e-01 -1.59e-02 9.55e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 9.29e-01 -1.56e-02 9.74e-01
PPARA activates gene expression 106 7.85e-01 1.53e-02 9.09e-01
FGFR1 mutant receptor activation 25 8.95e-01 1.52e-02 9.55e-01
Chromosome Maintenance 93 8.02e-01 1.51e-02 9.15e-01
Glutathione conjugation 28 8.90e-01 -1.51e-02 9.54e-01
DNA Damage/Telomere Stress Induced Senescence 33 8.81e-01 -1.50e-02 9.50e-01
Cell Cycle 585 5.43e-01 1.48e-02 7.50e-01
Signaling by NOTCH2 31 8.89e-01 1.46e-02 9.53e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 11 9.35e-01 1.42e-02 9.76e-01
Processing of Capped Intronless Pre-mRNA 29 8.95e-01 1.42e-02 9.55e-01
Class B/2 (Secretin family receptors) 55 8.56e-01 -1.41e-02 9.40e-01
IRF3-mediated induction of type I IFN 12 9.34e-01 1.38e-02 9.76e-01
Telomere C-strand synthesis initiation 13 9.32e-01 -1.37e-02 9.74e-01
WNT ligand biogenesis and trafficking 17 9.22e-01 1.36e-02 9.69e-01
Chaperonin-mediated protein folding 74 8.43e-01 1.33e-02 9.32e-01
DNA Repair 281 7.02e-01 1.33e-02 8.61e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 9.20e-01 1.30e-02 9.69e-01
Signaling by TGFB family members 115 8.11e-01 -1.29e-02 9.17e-01
Pyroptosis 22 9.17e-01 -1.28e-02 9.69e-01
DNA Double-Strand Break Repair 131 8.02e-01 1.27e-02 9.15e-01
RHOH GTPase cycle 31 9.03e-01 1.27e-02 9.59e-01
Mitotic Spindle Checkpoint 103 8.29e-01 1.23e-02 9.24e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 30 9.08e-01 -1.22e-02 9.63e-01
tRNA processing 109 8.28e-01 1.20e-02 9.24e-01
Signaling by Insulin receptor 66 8.66e-01 -1.20e-02 9.46e-01
Regulation of insulin secretion 59 8.74e-01 -1.20e-02 9.49e-01
Developmental Biology 793 5.70e-01 1.19e-02 7.70e-01
Regulation of TNFR1 signaling 48 8.87e-01 1.19e-02 9.53e-01
Signaling by FGFR1 in disease 32 9.09e-01 -1.17e-02 9.63e-01
Sphingolipid de novo biosynthesis 37 9.03e-01 1.16e-02 9.59e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 8.74e-01 -1.15e-02 9.49e-01
Dual incision in TC-NER 65 8.73e-01 -1.15e-02 9.49e-01
Metabolism 1747 4.46e-01 -1.11e-02 6.82e-01
Class A/1 (Rhodopsin-like receptors) 146 8.17e-01 1.11e-02 9.17e-01
Transcriptional regulation by small RNAs 54 8.89e-01 -1.10e-02 9.53e-01
Signalling to ERKs 33 9.18e-01 1.03e-02 9.69e-01
Inactivation of CSF3 (G-CSF) signaling 25 9.30e-01 1.01e-02 9.74e-01
Plasma lipoprotein assembly 11 9.54e-01 1.01e-02 9.88e-01
Attachment and Entry 9694614 15 9.47e-01 1.00e-02 9.81e-01
Phosphorylation of the APC/C 20 9.39e-01 9.95e-03 9.79e-01
The phototransduction cascade 20 9.40e-01 9.69e-03 9.79e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 8.78e-01 -9.67e-03 9.49e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 9.37e-01 -9.35e-03 9.78e-01
B-WICH complex positively regulates rRNA expression 38 9.21e-01 9.24e-03 9.69e-01
Resolution of Abasic Sites (AP sites) 38 9.23e-01 9.12e-03 9.69e-01
Signal Transduction 2041 5.09e-01 9.02e-03 7.27e-01
Negative regulators of DDX58/IFIH1 signaling 34 9.29e-01 8.87e-03 9.74e-01
Blood group systems biosynthesis 13 9.57e-01 -8.70e-03 9.89e-01
CLEC7A (Dectin-1) induces NFAT activation 11 9.60e-01 8.70e-03 9.89e-01
Formation of the Early Elongation Complex 33 9.32e-01 8.64e-03 9.74e-01
Formation of the HIV-1 Early Elongation Complex 33 9.32e-01 8.64e-03 9.74e-01
Telomere Maintenance 70 9.02e-01 -8.55e-03 9.59e-01
Common Pathway of Fibrin Clot Formation 10 9.63e-01 -8.49e-03 9.89e-01
RNA Polymerase II Transcription 1196 6.29e-01 -8.38e-03 8.07e-01
Inwardly rectifying K+ channels 23 9.46e-01 -8.12e-03 9.81e-01
Negative epigenetic regulation of rRNA expression 56 9.18e-01 -8.00e-03 9.69e-01
M Phase 343 8.03e-01 7.86e-03 9.15e-01
Gene expression (Transcription) 1354 6.37e-01 -7.72e-03 8.12e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 9.66e-01 7.52e-03 9.89e-01
alpha-linolenic acid (ALA) metabolism 11 9.66e-01 7.52e-03 9.89e-01
RMTs methylate histone arginines 33 9.41e-01 7.50e-03 9.79e-01
Pre-NOTCH Processing in Golgi 18 9.58e-01 -7.23e-03 9.89e-01
Pre-NOTCH Transcription and Translation 40 9.40e-01 -6.93e-03 9.79e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 9.71e-01 6.67e-03 9.89e-01
Gene Silencing by RNA 79 9.20e-01 -6.51e-03 9.69e-01
Transport of small molecules 541 7.97e-01 -6.49e-03 9.15e-01
Cyclin D associated events in G1 45 9.45e-01 5.91e-03 9.81e-01
G1 Phase 45 9.45e-01 5.91e-03 9.81e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 9.70e-01 -5.86e-03 9.89e-01
Cohesin Loading onto Chromatin 10 9.75e-01 5.76e-03 9.91e-01
Basigin interactions 22 9.63e-01 5.75e-03 9.89e-01
Acyl chain remodelling of PS 16 9.69e-01 -5.62e-03 9.89e-01
GPCR ligand binding 204 8.93e-01 5.50e-03 9.54e-01
NoRC negatively regulates rRNA expression 53 9.45e-01 5.46e-03 9.81e-01
Growth hormone receptor signaling 19 9.68e-01 5.37e-03 9.89e-01
Nucleotide Excision Repair 110 9.23e-01 5.35e-03 9.69e-01
MET receptor recycling 10 9.77e-01 -5.32e-03 9.91e-01
Synthesis, secretion, and deacylation of Ghrelin 11 9.76e-01 5.21e-03 9.91e-01
Transcriptional Regulation by NPAS4 31 9.60e-01 -5.16e-03 9.89e-01
Sialic acid metabolism 28 9.64e-01 4.98e-03 9.89e-01
PIWI-interacting RNA (piRNA) biogenesis 21 9.71e-01 -4.65e-03 9.89e-01
Extra-nuclear estrogen signaling 63 9.52e-01 -4.40e-03 9.86e-01
tRNA modification in the nucleus and cytosol 43 9.60e-01 4.37e-03 9.89e-01
MET activates RAS signaling 11 9.80e-01 4.33e-03 9.91e-01
Late endosomal microautophagy 31 9.68e-01 -4.15e-03 9.89e-01
Membrane binding and targetting of GAG proteins 14 9.79e-01 4.07e-03 9.91e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 9.79e-01 4.07e-03 9.91e-01
Condensation of Prophase Chromosomes 20 9.75e-01 -4.04e-03 9.91e-01
TAK1-dependent IKK and NF-kappa-B activation 43 9.64e-01 -4.02e-03 9.89e-01
RHOD GTPase cycle 50 9.61e-01 4.01e-03 9.89e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 9.68e-01 3.82e-03 9.89e-01
RNA Polymerase I Promoter Clearance 57 9.61e-01 3.72e-03 9.89e-01
RNA Polymerase I Transcription 57 9.61e-01 3.72e-03 9.89e-01
RHOB GTPase cycle 65 9.60e-01 -3.64e-03 9.89e-01
Transcriptional Regulation by TP53 340 9.09e-01 -3.63e-03 9.63e-01
Metabolism of fat-soluble vitamins 32 9.75e-01 -3.26e-03 9.91e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 9.87e-01 -2.87e-03 9.95e-01
Synthesis of PIPs at the late endosome membrane 11 9.87e-01 -2.76e-03 9.95e-01
Potassium Channels 54 9.73e-01 -2.71e-03 9.90e-01
Peptide ligand-binding receptors 80 9.68e-01 -2.62e-03 9.89e-01
Dopamine Neurotransmitter Release Cycle 18 9.87e-01 2.26e-03 9.95e-01
p38MAPK events 13 9.89e-01 -2.11e-03 9.95e-01
HCMV Late Events 60 9.79e-01 2.00e-03 9.91e-01
Glutamate Neurotransmitter Release Cycle 20 9.89e-01 1.86e-03 9.95e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 9.81e-01 1.73e-03 9.91e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 39 9.85e-01 -1.69e-03 9.95e-01
NS1 Mediated Effects on Host Pathways 40 9.89e-01 -1.25e-03 9.95e-01
Biological oxidations 138 9.83e-01 1.03e-03 9.94e-01
Oncogene Induced Senescence 32 9.94e-01 -8.32e-04 9.97e-01
Deadenylation of mRNA 22 9.95e-01 8.19e-04 9.97e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.95e-01 -7.80e-04 9.97e-01
Protein folding 80 9.93e-01 -5.94e-04 9.97e-01
RNA Polymerase I Transcription Termination 30 9.98e-01 3.27e-04 9.98e-01
Ca2+ pathway 53 9.97e-01 -3.12e-04 9.98e-01
Metabolism of amino acids and derivatives 319 9.95e-01 1.96e-04 9.97e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 51 1.00e+00 -2.97e-05 1.00e+00


Detailed Gene set reports



Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
374
set Expression and translocation of olfactory receptors
setSize 21
pANOVA 1.14e-09
s.dist -0.767
p.adjustANOVA 5.58e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR1D2 -8603
OR10G3 -8486
OR2AT4 -8388
OR2M3 -8371
OR56A1 -8366
OR6Y1 -8133
REEP1 -8075
OR5A1 -8070
OR6C75 -8067
OR7C1 -8041
OR5AN1 -7755
OR4D9 -7219
OR52K1 -7007
OR8A1 -6940
OR14J1 -6700
OR5AS1 -6290
OR5A2 -5727
OR10H5 -4930
OR1I1 -4816
EBF1 -4338

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR1D2 -8603
OR10G3 -8486
OR2AT4 -8388
OR2M3 -8371
OR56A1 -8366
OR6Y1 -8133
REEP1 -8075
OR5A1 -8070
OR6C75 -8067
OR7C1 -8041
OR5AN1 -7755
OR4D9 -7219
OR52K1 -7007
OR8A1 -6940
OR14J1 -6700
OR5AS1 -6290
OR5A2 -5727
OR10H5 -4930
OR1I1 -4816
EBF1 -4338
LDB1 4096


Zinc transporters

Zinc transporters
1430
set Zinc transporters
setSize 10
pANOVA 8.19e-05
s.dist 0.719
p.adjustANOVA 0.00108



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC39A6 7578
SLC39A7 7217
SLC39A14 6999
SLC39A8 6799
SLC39A4 5666
SLC39A10 5364
SLC39A1 5195
SLC39A3 4112
SLC30A1 4090
SLC30A5 3202

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC39A6 7578
SLC39A7 7217
SLC39A14 6999
SLC39A8 6799
SLC39A4 5666
SLC39A10 5364
SLC39A1 5195
SLC39A3 4112
SLC30A1 4090
SLC30A5 3202


Olfactory Signaling Pathway

Olfactory Signaling Pathway
804
set Olfactory Signaling Pathway
setSize 25
pANOVA 2.19e-09
s.dist -0.691
p.adjustANOVA 1.04e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR1D2 -8603
OR10G3 -8486
OR2AT4 -8388
OR2M3 -8371
OR56A1 -8366
ANO2 -8325
OR6Y1 -8133
REEP1 -8075
OR5A1 -8070
OR6C75 -8067
OR7C1 -8041
OR5AN1 -7755
OR4D9 -7219
OR52K1 -7007
OR8A1 -6940
OR14J1 -6700
OR5AS1 -6290
OR5A2 -5727
OR10H5 -4930
OR1I1 -4816

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR1D2 -8603
OR10G3 -8486
OR2AT4 -8388
OR2M3 -8371
OR56A1 -8366
ANO2 -8325
OR6Y1 -8133
REEP1 -8075
OR5A1 -8070
OR6C75 -8067
OR7C1 -8041
OR5AN1 -7755
OR4D9 -7219
OR52K1 -7007
OR8A1 -6940
OR14J1 -6700
OR5AS1 -6290
OR5A2 -5727
OR10H5 -4930
OR1I1 -4816
GNAL -4667
ADCY3 -4635
EBF1 -4338
LDB1 4096
GNB1 6687


Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation
45
set Activation of PPARGC1A (PGC-1alpha) by phosphorylation
setSize 10
pANOVA 0.000157
s.dist -0.69
p.adjustANOVA 0.00175



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK11 -8438
MAPK12 -8000
PRKAB1 -7394
PRKAB2 -7185
PRKAA2 -6904
PRKAG3 -6335
PPARGC1A -6075
PRKAG1 -4935
MAPK14 -3390
PRKAG2 -1791

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK11 -8438
MAPK12 -8000
PRKAB1 -7394
PRKAB2 -7185
PRKAA2 -6904
PRKAG3 -6335
PPARGC1A -6075
PRKAG1 -4935
MAPK14 -3390
PRKAG2 -1791


Trafficking and processing of endosomal TLR

Trafficking and processing of endosomal TLR
1344
set Trafficking and processing of endosomal TLR
setSize 12
pANOVA 0.000118
s.dist 0.642
p.adjustANOVA 0.00147



Top enriched genes

Top 20 genes
GeneID Gene Rank
TLR8 7399
HSP90B1 7298
UNC93B1 6561
CNPY3 6178
TLR9 6062
CTSB 5931
CTSS 5264
TLR7 4561
CTSK 3879
LGMN 3867
CTSL 3114
TLR3 -326

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR8 7399
HSP90B1 7298
UNC93B1 6561
CNPY3 6178
TLR9 6062
CTSB 5931
CTSS 5264
TLR7 4561
CTSK 3879
LGMN 3867
CTSL 3114
TLR3 -326


FCGR activation

FCGR activation
382
set FCGR activation
setSize 10
pANOVA 0.000477
s.dist 0.638
p.adjustANOVA 0.00459



Top enriched genes

Top 20 genes
GeneID Gene Rank
FCGR2A 7670
FCGR1A 7558
SYK 7279
SRC 6997
HCK 5764
FGR 5454
LYN 5261
FCGR3A 2394
FYN 1420
YES1 -304

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FCGR2A 7670
FCGR1A 7558
SYK 7279
SRC 6997
HCK 5764
FGR 5454
LYN 5261
FCGR3A 2394
FYN 1420
YES1 -304


Keratan sulfate degradation

Keratan sulfate degradation
615
set Keratan sulfate degradation
setSize 13
pANOVA 1e-04
s.dist 0.623
p.adjustANOVA 0.00129



Top enriched genes

Top 20 genes
GeneID Gene Rank
OGN 7621
LUM 7324
FMOD 7283
OMD 6806
HEXB 6467
GALNS 6296
ACAN 6261
PRELP 5584
GLB1L 5504
HEXA 4725
GLB1 4368
GNS 3085
KERA -8607

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OGN 7621
LUM 7324
FMOD 7283
OMD 6806
HEXB 6467
GALNS 6296
ACAN 6261
PRELP 5584
GLB1L 5504
HEXA 4725
GLB1 4368
GNS 3085
KERA -8607


Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)
197
set Citric acid cycle (TCA cycle)
setSize 22
pANOVA 1.6e-06
s.dist -0.591
p.adjustANOVA 4.12e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
OGDH -7041
MDH2 -6982
SUCLA2 -6905
IDH2 -6714
SDHD -6432
CS -6430
SDHA -6420
ACO2 -6392
NNT -6385
IDH3B -6239
SUCLG2 -6161
FH -5919
SDHB -5708
SUCLG1 -5586
DLD -5578
IDH3A -5422
DLST -4465
SDHC -3815
FAHD1 -3182
ME2 -2069

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OGDH -7041
MDH2 -6982
SUCLA2 -6905
IDH2 -6714
SDHD -6432
CS -6430
SDHA -6420
ACO2 -6392
NNT -6385
IDH3B -6239
SUCLG2 -6161
FH -5919
SDHB -5708
SUCLG1 -5586
DLD -5578
IDH3A -5422
DLST -4465
SDHC -3815
FAHD1 -3182
ME2 -2069
ME3 -1127
IDH3G 163


Mucopolysaccharidoses

Mucopolysaccharidoses
718
set Mucopolysaccharidoses
setSize 11
pANOVA 0.000875
s.dist 0.579
p.adjustANOVA 0.00736



Top enriched genes

Top 20 genes
GeneID Gene Rank
IDS 6796
GALNS 6296
NAGLU 5678
GUSB 5658
HGSNAT 5558
IDUA 5436
GLB1 4368
ARSB 3440
GNS 3085
SGSH 2278
HYAL1 521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IDS 6796
GALNS 6296
NAGLU 5678
GUSB 5658
HGSNAT 5558
IDUA 5436
GLB1 4368
ARSB 3440
GNS 3085
SGSH 2278
HYAL1 521


Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation
856
set Phase 0 - rapid depolarisation
setSize 27
pANOVA 5.86e-07
s.dist -0.555
p.adjustANOVA 1.78e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF12 -8551
SCN4B -8293
FGF13 -8124
SCN1B -8060
SCN2A -8045
CAMK2A -8006
CAMK2G -7972
SCN3A -7870
CACNG8 -7171
CAMK2B -6993
CACNB2 -6822
SCN9A -6388
CAMK2D -6238
SCN11A -6203
CACNB1 -6152
SCN3B -5746
SCN7A -5474
CACNG6 -5052
SCN4A -4450
SCN8A -3314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF12 -8551
SCN4B -8293
FGF13 -8124
SCN1B -8060
SCN2A -8045
CAMK2A -8006
CAMK2G -7972
SCN3A -7870
CACNG8 -7171
CAMK2B -6993
CACNB2 -6822
SCN9A -6388
CAMK2D -6238
SCN11A -6203
CACNB1 -6152
SCN3B -5746
SCN7A -5474
CACNG6 -5052
SCN4A -4450
SCN8A -3314
CALM1 -3100
CACNA1C -2662
FGF14 -1920
SCN2B -1526
CACNA2D2 1050
RANGRF 2446
FGF11 7680


Regulation of CDH11 gene transcription

Regulation of CDH11 gene transcription
1015
set Regulation of CDH11 gene transcription
setSize 10
pANOVA 0.00237
s.dist 0.555
p.adjustANOVA 0.0164



Top enriched genes

Top 20 genes
GeneID Gene Rank
CDH11 7576
BHLHE22 7574
PRDM8 6982
SNAI1 6922
ZEB2 6553
SP1 5494
ILF3 5357
HOXC8 1855
FOXF1 1606
HEYL -7287

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CDH11 7576
BHLHE22 7574
PRDM8 6982
SNAI1 6922
ZEB2 6553
SP1 5494
ILF3 5357
HOXC8 1855
FOXF1 1606
HEYL -7287


Metal ion SLC transporters

Metal ion SLC transporters
689
set Metal ion SLC transporters
setSize 18
pANOVA 6.51e-05
s.dist 0.544
p.adjustANOVA 0.000899



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC41A2 7637
SLC39A6 7578
SLC11A1 7339
SLC39A7 7217
SLC39A14 6999
SLC31A1 6863
SLC39A8 6799
SLC39A4 5666
SLC39A10 5364
SLC39A1 5195
SLC11A2 5037
SLC39A3 4112
SLC30A1 4090
SLC30A5 3202
CP 1614
HEPH -1423
SLC40A1 -2389
SLC41A1 -5901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC41A2 7637
SLC39A6 7578
SLC11A1 7339
SLC39A7 7217
SLC39A14 6999
SLC31A1 6863
SLC39A8 6799
SLC39A4 5666
SLC39A10 5364
SLC39A1 5195
SLC11A2 5037
SLC39A3 4112
SLC30A1 4090
SLC30A5 3202
CP 1614
HEPH -1423
SLC40A1 -2389
SLC41A1 -5901


Retrograde neurotrophin signalling

Retrograde neurotrophin signalling
1083
set Retrograde neurotrophin signalling
setSize 13
pANOVA 0.00073
s.dist 0.541
p.adjustANOVA 0.00636



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNM1 6958
NTRK1 6852
AP2A1 5913
NGF 5506
AP2M1 5465
CLTC 5021
AP2B1 4934
CLTA 4648
AP2S1 4610
DNAL4 3796
AP2A2 3259
DNM2 1903
DNM3 -4958

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNM1 6958
NTRK1 6852
AP2A1 5913
NGF 5506
AP2M1 5465
CLTC 5021
AP2B1 4934
CLTA 4648
AP2S1 4610
DNAL4 3796
AP2A2 3259
DNM2 1903
DNM3 -4958


Nitric oxide stimulates guanylate cyclase

Nitric oxide stimulates guanylate cyclase
776
set Nitric oxide stimulates guanylate cyclase
setSize 17
pANOVA 0.000133
s.dist -0.535
p.adjustANOVA 0.00156



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDE5A -8601
IRAG1 -8457
NOS3 -8416
PRKG1 -8087
PDE9A -8033
PDE2A -7702
KCNMB4 -6735
NOS1 -6693
PDE10A -5786
KCNMB3 -5672
GUCY1A2 -4246
PDE11A -2771
KCNMB1 -2216
PDE1A -1268
ITPR1 -353
KCNMA1 1877
PDE1B 2240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDE5A -8601
IRAG1 -8457
NOS3 -8416
PRKG1 -8087
PDE9A -8033
PDE2A -7702
KCNMB4 -6735
NOS1 -6693
PDE10A -5786
KCNMB3 -5672
GUCY1A2 -4246
PDE11A -2771
KCNMB1 -2216
PDE1A -1268
ITPR1 -353
KCNMA1 1877
PDE1B 2240


Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
319
set Dissolution of Fibrin Clot
setSize 10
pANOVA 0.00348
s.dist 0.534
p.adjustANOVA 0.0224



Top enriched genes

Top 20 genes
GeneID Gene Rank
SERPINE1 7524
PLAUR 7506
ANXA2 7042
S100A10 6881
SERPINB8 6461
PLAU 5696
SERPINB6 3764
SERPINE2 3502
SERPINF2 473
PLAT -7998

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SERPINE1 7524
PLAUR 7506
ANXA2 7042
S100A10 6881
SERPINB8 6461
PLAU 5696
SERPINB6 3764
SERPINE2 3502
SERPINF2 473
PLAT -7998


Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation
494
set Glyoxylate metabolism and glycine degradation
setSize 24
pANOVA 6.82e-06
s.dist -0.53
p.adjustANOVA 0.000141



Top enriched genes

Top 20 genes
GeneID Gene Rank
OGDH -7041
GCSH -7013
PDHX -6946
ALDH4A1 -6917
PDHB -6842
NDUFAB1 -6767
DLAT -6378
GOT2 -6345
LIAS -6325
LIPT2 -5637
DLD -5578
GLDC -5413
DHTKD1 -5322
HOGA1 -4679
PDHA1 -4601
DLST -4465
DBT -4323
PXMP2 -4269
GRHPR -4135
BCKDHA -2817

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OGDH -7041
GCSH -7013
PDHX -6946
ALDH4A1 -6917
PDHB -6842
NDUFAB1 -6767
DLAT -6378
GOT2 -6345
LIAS -6325
LIPT2 -5637
DLD -5578
GLDC -5413
DHTKD1 -5322
HOGA1 -4679
PDHA1 -4601
DLST -4465
DBT -4323
PXMP2 -4269
GRHPR -4135
BCKDHA -2817
BCKDHB -1928
LIPT1 -1189
DDO 567
AMT 1103


CS/DS degradation

CS/DS degradation
143
set CS/DS degradation
setSize 10
pANOVA 0.00423
s.dist 0.522
p.adjustANOVA 0.026



Top enriched genes

Top 20 genes
GeneID Gene Rank
BGN 7799
IDS 6796
HEXB 6467
IDUA 5436
HEXA 4725
ARSB 3440
CSPG4 2647
DCN 1698
HYAL1 521
VCAN 398

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 7799
IDS 6796
HEXB 6467
IDUA 5436
HEXA 4725
ARSB 3440
CSPG4 2647
DCN 1698
HYAL1 521
VCAN 398


Complex I biogenesis

Complex I biogenesis
214
set Complex I biogenesis
setSize 51
pANOVA 1.77e-10
s.dist -0.516
p.adjustANOVA 9.57e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFAF5 -8494
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA5 -6949
NDUFAF6 -6817
NDUFS3 -6796
NDUFAB1 -6767
NDUFA7 -6529
NDUFS1 -6499
NDUFA12 -6301
NDUFB5 -6298
NDUFAF4 -6214
NDUFB10 -6208
NDUFS2 -5996
NDUFA8 -5850
NDUFC1 -5771
TIMMDC1 -5690
NDUFS4 -5557
NDUFS7 -5537

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFAF5 -8494
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA5 -6949
NDUFAF6 -6817
NDUFS3 -6796
NDUFAB1 -6767
NDUFA7 -6529
NDUFS1 -6499
NDUFA12 -6301
NDUFB5 -6298
NDUFAF4 -6214
NDUFB10 -6208
NDUFS2 -5996
NDUFA8 -5850
NDUFC1 -5771
TIMMDC1 -5690
NDUFS4 -5557
NDUFS7 -5537
NDUFS8 -5458
ECSIT -5411
NDUFC2 -5279
NDUFB1 -5275
NDUFB6 -5204
NDUFB7 -5070
NDUFAF1 -5064
NDUFB3 -4784
NDUFA10 -4739
NDUFV1 -4619
COA1 -4600
NDUFB4 -4597
NDUFB8 -4561
NDUFA6 -4515
NDUFB11 -4493
NDUFV3 -4345
NDUFA2 -4262
NDUFAF2 -4182
NDUFS6 -3885
NDUFB2 -3823
TMEM186 -3335
TMEM126B -2352
NDUFS5 -2177
NDUFA1 -1919
NDUFAF3 -1022
NDUFA13 -825
NUBPL -769
NDUFA3 -741
NDUFAF7 330
NDUFA11 795
ACAD9 2687


Striated Muscle Contraction

Striated Muscle Contraction
1252
set Striated Muscle Contraction
setSize 35
pANOVA 1.61e-07
s.dist -0.512
p.adjustANOVA 5.62e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACTC1 -8614
TNNI3 -8530
TNNT2 -8226
TPM1 -8212
TPM2 -7850
DMD -7693
TPM3 -7553
MYH6 -7502
TMOD1 -7499
MYH3 -7436
TTN -6562
MYBPC1 -6503
TNNT3 -6150
ACTA1 -6040
MYL2 -5870
TNNI2 -5789
MYL1 -5542
TNNI1 -5423
TCAP -5412
MYBPC2 -5403

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACTC1 -8614
TNNI3 -8530
TNNT2 -8226
TPM1 -8212
TPM2 -7850
DMD -7693
TPM3 -7553
MYH6 -7502
TMOD1 -7499
MYH3 -7436
TTN -6562
MYBPC1 -6503
TNNT3 -6150
ACTA1 -6040
MYL2 -5870
TNNI2 -5789
MYL1 -5542
TNNI1 -5423
TCAP -5412
MYBPC2 -5403
MYL3 -4879
ACTN2 -4871
TNNT1 -4584
DES -4357
TNNC1 -4288
TNNC2 -4077
NEB -3892
TMOD4 -3209
ACTN3 -3032
MYH8 -2265
TMOD2 -1607
TMOD3 1127
MYBPC3 4538
TPM4 6415
VIM 7169


The activation of arylsulfatases

The activation of arylsulfatases
1324
set The activation of arylsulfatases
setSize 10
pANOVA 0.00544
s.dist 0.508
p.adjustANOVA 0.0317



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARSD 6506
SUMF1 6451
ARSI 6156
ARSJ 5143
ARSA 4186
ARSB 3440
ARSK 3074
SUMF2 2861
ARSG 2730
STS -1843

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARSD 6506
SUMF1 6451
ARSI 6156
ARSJ 5143
ARSA 4186
ARSB 3440
ARSK 3074
SUMF2 2861
ARSG 2730
STS -1843


SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1093
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 2.82e-07
s.dist 0.495
p.adjustANOVA 9.17e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPS17 7247
RPS27 7112
RPS19 6965
RPS27L 6659
RPS15 6574
EEF1A1 6039
RPS9 5706
RPS8 5435
RPS10 5228
FAU 5014
RPS2 4712
RPS6 4687
RPS20 4577
RPS5 4421
HNRNPA1 4353
RPS11 4336
RPS29 4087
RPS12 4051
RPS27A 4009

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPS17 7247
RPS27 7112
RPS19 6965
RPS27L 6659
RPS15 6574
EEF1A1 6039
RPS9 5706
RPS8 5435
RPS10 5228
FAU 5014
RPS2 4712
RPS6 4687
RPS20 4577
RPS5 4421
HNRNPA1 4353
RPS11 4336
RPS29 4087
RPS12 4051
RPS27A 4009
RPS3 3802
RPSA 3455
RPS4X 3357
RPS3A 3340
RPS18 3231
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
RPS15A 1135
RPS23 1051
RPS16 948
RPS4Y1 -419
RPS28 -970
RPS25 -1388
RPS13 -1540


Diseases associated with N-glycosylation of proteins

Diseases associated with N-glycosylation of proteins
302
set Diseases associated with N-glycosylation of proteins
setSize 20
pANOVA 0.00013
s.dist 0.494
p.adjustANOVA 0.00156



Top enriched genes

Top 20 genes
GeneID Gene Rank
B4GALT1 7539
MAN1B1 6801
MOGS 6058
RFT1 5903
ALG2 5807
ALG12 5511
MGAT2 5337
CTSA 5186
MPDU1 5000
ALG11 4563
GLB1 4368
ALG3 4266
DPAGT1 4265
ALG13 3441
NEU1 2998
ALG8 1647
ALG1 1587
ALG9 94
ALG14 -1762
ALG6 -3458

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B4GALT1 7539
MAN1B1 6801
MOGS 6058
RFT1 5903
ALG2 5807
ALG12 5511
MGAT2 5337
CTSA 5186
MPDU1 5000
ALG11 4563
GLB1 4368
ALG3 4266
DPAGT1 4265
ALG13 3441
NEU1 2998
ALG8 1647
ALG1 1587
ALG9 94
ALG14 -1762
ALG6 -3458


mitochondrial fatty acid beta-oxidation of saturated fatty acids

mitochondrial fatty acid beta-oxidation of saturated fatty acids
1444
set mitochondrial fatty acid beta-oxidation of saturated fatty acids
setSize 10
pANOVA 0.00681
s.dist -0.494
p.adjustANOVA 0.038



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACADL -6111
HADH -5751
ACADM -5595
MECR -5111
HADHB -4822
ECHS1 -4313
ACADS -3922
ACSM3 -3793
HADHA -3217
ACADVL -1589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACADL -6111
HADH -5751
ACADM -5595
MECR -5111
HADHB -4822
ECHS1 -4313
ACADS -3922
ACSM3 -3793
HADHA -3217
ACADVL -1589


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
406
set Formation of ATP by chemiosmotic coupling
setSize 16
pANOVA 0.000648
s.dist -0.492
p.adjustANOVA 0.00585



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5F1B -6804
ATP5F1A -6528
ATP5F1C -6348
ATP5F1D -6338
ATP5PF -6158
DMAC2L -5620
ATP5MC3 -5610
ATP5MC1 -5597
ATP5PB -5580
ATP5MC2 -5482
ATP5PO -5284
ATP5MG -3234
ATP5PD -3034
ATP5MF -1412
ATP5F1E 1090
ATP5ME 1430

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5F1B -6804
ATP5F1A -6528
ATP5F1C -6348
ATP5F1D -6338
ATP5PF -6158
DMAC2L -5620
ATP5MC3 -5610
ATP5MC1 -5597
ATP5PB -5580
ATP5MC2 -5482
ATP5PO -5284
ATP5MG -3234
ATP5PD -3034
ATP5MF -1412
ATP5F1E 1090
ATP5ME 1430


cGMP effects

cGMP effects
1434
set cGMP effects
setSize 14
pANOVA 0.00146
s.dist -0.491
p.adjustANOVA 0.0111



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDE5A -8601
IRAG1 -8457
PRKG1 -8087
PDE9A -8033
PDE2A -7702
KCNMB4 -6735
PDE10A -5786
KCNMB3 -5672
PDE11A -2771
KCNMB1 -2216
PDE1A -1268
ITPR1 -353
KCNMA1 1877
PDE1B 2240

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDE5A -8601
IRAG1 -8457
PRKG1 -8087
PDE9A -8033
PDE2A -7702
KCNMB4 -6735
PDE10A -5786
KCNMB3 -5672
PDE11A -2771
KCNMB1 -2216
PDE1A -1268
ITPR1 -353
KCNMA1 1877
PDE1B 2240


RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF
993
set RUNX3 regulates p14-ARF
setSize 10
pANOVA 0.00781
s.dist 0.486
p.adjustANOVA 0.043



Top enriched genes

Top 20 genes
GeneID Gene Rank
RUNX1 7052
CCND1 6885
TGFB1 6540
EP300 5332
RUNX3 4611
CDKN2A 3947
BRD2 3534
CBFB 1275
KRAS -1021
HDAC4 -1257

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RUNX1 7052
CCND1 6885
TGFB1 6540
EP300 5332
RUNX3 4611
CDKN2A 3947
BRD2 3534
CBFB 1275
KRAS -1021
HDAC4 -1257


Respiratory electron transport

Respiratory electron transport
1076
set Respiratory electron transport
setSize 93
pANOVA 6.23e-16
s.dist -0.485
p.adjustANOVA 1.52e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFAF5 -8494
CYCS -7721
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA4 -7079
NDUFA5 -6949
UQCRFS1 -6912
COX5A -6864
NDUFAF6 -6817
COX11 -6798
NDUFS3 -6796
NDUFAB1 -6767
CYC1 -6586
UQCR10 -6554
NDUFA7 -6529
NDUFS1 -6499
SDHD -6432
SDHA -6420
UQCRC2 -6331

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFAF5 -8494
CYCS -7721
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA4 -7079
NDUFA5 -6949
UQCRFS1 -6912
COX5A -6864
NDUFAF6 -6817
COX11 -6798
NDUFS3 -6796
NDUFAB1 -6767
CYC1 -6586
UQCR10 -6554
NDUFA7 -6529
NDUFS1 -6499
SDHD -6432
SDHA -6420
UQCRC2 -6331
COX6C -6312
NDUFA12 -6301
NDUFB5 -6298
COX8A -6273
NDUFAF4 -6214
NDUFB10 -6208
COQ10A -6186
COX7B -6024
NDUFS2 -5996
UQCRC1 -5863
NDUFA8 -5850
TACO1 -5802
NDUFC1 -5771
SDHB -5708
TIMMDC1 -5690
NDUFS4 -5557
ETFA -5555
COX14 -5546
NDUFS7 -5537
TRAP1 -5472
NDUFS8 -5458
ECSIT -5411
COX5B -5370
UQCRB -5317
NDUFC2 -5279
NDUFB1 -5275
COX7C -5222
NDUFB6 -5204
NDUFB7 -5070
NDUFAF1 -5064
UQCR11 -5049
NDUFB3 -4784
NDUFA10 -4739
UQCRQ -4697
NDUFV1 -4619
COA1 -4600
NDUFB4 -4597
NDUFB8 -4561
NDUFA6 -4515
LRPPRC -4508
NDUFB11 -4493
COX4I1 -4408
NDUFV3 -4345
NDUFA2 -4262
NDUFAF2 -4182
COX16 -3962
NDUFS6 -3885
NDUFB2 -3823
SDHC -3815
UQCRH -3376
TMEM186 -3335
ETFB -3229
COX6B1 -2908
ETFDH -2726
SCO1 -2624
TMEM126B -2352
NDUFS5 -2177
NDUFA1 -1919
COX20 -1575
COX18 -1165
COQ10B -1031
NDUFAF3 -1022
NDUFA13 -825
NUBPL -769
NDUFA3 -741
SURF1 -319
NDUFAF7 330
NDUFA11 795
COX7A2L 1828
ACAD9 2687
COX19 3870
COX6A1 6696
SCO2 7410


WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4
1426
set WNT5A-dependent internalization of FZD4
setSize 14
pANOVA 0.00172
s.dist 0.484
p.adjustANOVA 0.013



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKCB 7615
PRKCA 7057
ARRB2 7029
AP2A1 5913
AP2M1 5465
WNT5A 5463
CLTC 5021
AP2B1 4934
CLTA 4648
AP2S1 4610
AP2A2 3259
DVL2 2806
CLTB -4940
FZD4 -7468

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKCB 7615
PRKCA 7057
ARRB2 7029
AP2A1 5913
AP2M1 5465
WNT5A 5463
CLTC 5021
AP2B1 4934
CLTA 4648
AP2S1 4610
AP2A2 3259
DVL2 2806
CLTB -4940
FZD4 -7468


Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1077
set Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
setSize 113
pANOVA 1.84e-18
s.dist -0.477
p.adjustANOVA 5.39e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFAF5 -8494
CYCS -7721
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA4 -7079
UCP3 -7005
NDUFA5 -6949
UQCRFS1 -6912
COX5A -6864
NDUFAF6 -6817
ATP5F1B -6804
COX11 -6798
NDUFS3 -6796
NDUFAB1 -6767
CYC1 -6586
UQCR10 -6554
NDUFA7 -6529
ATP5F1A -6528
NDUFS1 -6499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFAF5 -8494
CYCS -7721
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA4 -7079
UCP3 -7005
NDUFA5 -6949
UQCRFS1 -6912
COX5A -6864
NDUFAF6 -6817
ATP5F1B -6804
COX11 -6798
NDUFS3 -6796
NDUFAB1 -6767
CYC1 -6586
UQCR10 -6554
NDUFA7 -6529
ATP5F1A -6528
NDUFS1 -6499
SDHD -6432
SDHA -6420
ATP5F1C -6348
ATP5F1D -6338
UQCRC2 -6331
COX6C -6312
NDUFA12 -6301
NDUFB5 -6298
COX8A -6273
NDUFAF4 -6214
NDUFB10 -6208
COQ10A -6186
ATP5PF -6158
COX7B -6024
NDUFS2 -5996
UQCRC1 -5863
NDUFA8 -5850
TACO1 -5802
NDUFC1 -5771
SDHB -5708
TIMMDC1 -5690
DMAC2L -5620
ATP5MC3 -5610
ATP5MC1 -5597
ATP5PB -5580
NDUFS4 -5557
ETFA -5555
COX14 -5546
NDUFS7 -5537
ATP5MC2 -5482
TRAP1 -5472
NDUFS8 -5458
ECSIT -5411
COX5B -5370
UQCRB -5317
ATP5PO -5284
NDUFC2 -5279
NDUFB1 -5275
COX7C -5222
NDUFB6 -5204
NDUFB7 -5070
NDUFAF1 -5064
UQCR11 -5049
NDUFB3 -4784
SLC25A27 -4759
NDUFA10 -4739
UQCRQ -4697
NDUFV1 -4619
COA1 -4600
NDUFB4 -4597
NDUFB8 -4561
NDUFA6 -4515
LRPPRC -4508
NDUFB11 -4493
COX4I1 -4408
NDUFV3 -4345
NDUFA2 -4262
NDUFAF2 -4182
COX16 -3962
NDUFS6 -3885
NDUFB2 -3823
SDHC -3815
UQCRH -3376
TMEM186 -3335
ATP5MG -3234
ETFB -3229
ATP5PD -3034
COX6B1 -2908
ETFDH -2726
SCO1 -2624
TMEM126B -2352
NDUFS5 -2177
NDUFA1 -1919
COX20 -1575
ATP5MF -1412
COX18 -1165
COQ10B -1031
NDUFAF3 -1022
NDUFA13 -825
NUBPL -769
NDUFA3 -741
SURF1 -319
UCP2 308
NDUFAF7 330
NDUFA11 795
ATP5F1E 1090
ATP5ME 1430
COX7A2L 1828
ACAD9 2687
SLC25A14 3153
COX19 3870
COX6A1 6696
SCO2 7410


Peptide chain elongation

Peptide chain elongation
849
set Peptide chain elongation
setSize 88
pANOVA 3.02e-14
s.dist 0.468
p.adjustANOVA 4.92e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
EEF1A1 6039
RPL3 5742
RPL11 5732
RPL35A 5710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
EEF1A1 6039
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
RPL29 1947
RPL7A 1934
RPL23A 1679
RPL30 1532
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
RPL27 -372
RPS4Y1 -419
RPL14 -613
RPL26L1 -874
RPL7 -906
RPS28 -970
EEF2 -989
RPS25 -1388
RPL38 -1519
RPS13 -1540
RPL37A -2628
RPLP1 -4830
RPL3L -5273


Viral mRNA Translation

Viral mRNA Translation
1416
set Viral mRNA Translation
setSize 88
pANOVA 1.52e-13
s.dist 0.455
p.adjustANOVA 1.71e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
DNAJC3 2656
RPS24 2481
RPS14 2363
RPL29 1947
RPL7A 1934
RPL23A 1679
RPL30 1532
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
RPL27 -372
RPS4Y1 -419
RPL14 -613
RPL26L1 -874
RPL7 -906
RPS28 -970
RPS25 -1388
RPL38 -1519
RPS13 -1540
RPL37A -2628
RPLP1 -4830
RPL3L -5273
GRSF1 -7046


Formation of annular gap junctions

Formation of annular gap junctions
416
set Formation of annular gap junctions
setSize 11
pANOVA 0.0096
s.dist 0.451
p.adjustANOVA 0.0508



Top enriched genes

Top 20 genes
GeneID Gene Rank
GJA1 7683
DNM1 6958
ACTG1 6850
ACTB 5585
AP2M1 5465
DAB2 5212
CLTC 5021
CLTA 4648
DNM2 1903
CLTB -4940
CLTCL1 -6970

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GJA1 7683
DNM1 6958
ACTG1 6850
ACTB 5585
AP2M1 5465
DAB2 5212
CLTC 5021
CLTA 4648
DNM2 1903
CLTB -4940
CLTCL1 -6970


Syndecan interactions

Syndecan interactions
1258
set Syndecan interactions
setSize 26
pANOVA 8.22e-05
s.dist 0.446
p.adjustANOVA 0.00108



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL5A1 7901
COL1A1 7897
COL3A1 7844
COL1A2 7835
COL5A2 7824
ITGB5 7736
TNC 7714
CASK 7648
PRKCA 7057
COL5A3 7018
FN1 6615
TGFB1 6540
SDC2 6020
SDC1 5346
ITGAV 4811
ITGB1 3394
ACTN1 2509
THBS1 2382
SDC3 1936
SDC4 1151

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL5A1 7901
COL1A1 7897
COL3A1 7844
COL1A2 7835
COL5A2 7824
ITGB5 7736
TNC 7714
CASK 7648
PRKCA 7057
COL5A3 7018
FN1 6615
TGFB1 6540
SDC2 6020
SDC1 5346
ITGAV 4811
ITGB1 3394
ACTN1 2509
THBS1 2382
SDC3 1936
SDC4 1151
TRAPPC4 979
ITGB3 -4260
FGF2 -4842
ITGA2 -5378
ITGA6 -7985
ITGB4 -8375


Mitochondrial translation elongation

Mitochondrial translation elongation
705
set Mitochondrial translation elongation
setSize 88
pANOVA 5e-13
s.dist -0.446
p.adjustANOVA 4.57e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
GFM1 -6209
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
GFM1 -6209
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973
MRPL20 -5963
MRPS31 -5954
MRPS18C -5838
MRPS26 -5716
MRPL3 -5675
MRPS17 -5651
MRPS11 -5596
MRPL18 -5573
MRPL37 -5572
MRPL44 -5487
MRPL35 -5439
MRPL50 -5363
MRPL30 -5359
MRPS24 -5350
AURKAIP1 -5304
MRPL14 -5269
MRPL45 -5223
MRPL22 -5216
MRPS6 -5136
MRPS30 -5123
TUFM -5119
TSFM -5081
MRPL2 -5032
MRPL40 -4980
MRPL38 -4809
MRPL34 -4734
MRPL41 -4717
MRPS12 -4632
MRPL58 -4545
MRPL24 -4399
MRPS33 -4278
MRPL16 -4251
MRPL42 -4233
OXA1L -4228
MRPS16 -4129
MRPL10 -4126
PTCD3 -4113
MRPL11 -3982
MRPL23 -3939
DAP3 -3911
MRPL49 -3851
MRPL21 -3712
MRPL53 -3603
MRPL57 -3417
MRPL47 -3400
MRPL36 -3098
MRPL4 -3008
MRPS25 -2993
MRPS36 -2689
MRPL32 -2344
MRPS5 -1867
MRPL9 -1438
MRPL48 -1433
MRPS14 -1167
MRPL43 -1166
GADD45GIP1 -1070
MRPL28 -952
MRPL52 -902
MRPS2 -745
MRPS34 -707
MRPL13 -59
MRPL51 225
MRPL27 2243
CHCHD1 2292
MRPL55 2827
MRPL54 4384
MRPL17 5209
MRPS21 6413


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
1425
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 13
pANOVA 0.00546
s.dist 0.445
p.adjustANOVA 0.0317



Top enriched genes

Top 20 genes
GeneID Gene Rank
FZD2 6928
AP2A1 5913
ROR2 5907
AP2M1 5465
WNT5A 5463
CLTC 5021
AP2B1 4934
CLTA 4648
AP2S1 4610
AP2A2 3259
ROR1 2642
CLTB -4940
FZD5 -6274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FZD2 6928
AP2A1 5913
ROR2 5907
AP2M1 5465
WNT5A 5463
CLTC 5021
AP2B1 4934
CLTA 4648
AP2S1 4610
AP2A2 3259
ROR1 2642
CLTB -4940
FZD5 -6274


Mitochondrial translation

Mitochondrial translation
704
set Mitochondrial translation
setSize 94
pANOVA 9.69e-14
s.dist -0.444
p.adjustANOVA 1.29e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
GFM1 -6209
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
GFM1 -6209
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973
MRPL20 -5963
MRPS31 -5954
MRPS18C -5838
MRPS26 -5716
MRPL3 -5675
MRPS17 -5651
MRPS11 -5596
MRPL18 -5573
MRPL37 -5572
MRPL44 -5487
MRPL35 -5439
GFM2 -5408
MRPL50 -5363
MRPL30 -5359
MRPS24 -5350
AURKAIP1 -5304
MRPL14 -5269
MRPL45 -5223
MRPL22 -5216
MRPS6 -5136
MRPS30 -5123
TUFM -5119
TSFM -5081
MRPL2 -5032
MTIF2 -5009
MRPL40 -4980
MRPL38 -4809
MRPL34 -4734
MRPL41 -4717
MRPS12 -4632
MRPL58 -4545
MRPL24 -4399
MRPS33 -4278
MRPL16 -4251
MRPL42 -4233
OXA1L -4228
MTFMT -4136
MRPS16 -4129
MRPL10 -4126
PTCD3 -4113
MRPL11 -3982
MTIF3 -3945
MRPL23 -3939
DAP3 -3911
MRPL49 -3851
MRPL21 -3712
MRPL53 -3603
MRPL57 -3417
MRPL47 -3400
MRRF -3378
MRPL36 -3098
MRPL4 -3008
MRPS25 -2993
MRPS36 -2689
MRPL32 -2344
MRPS5 -1867
MRPL9 -1438
MRPL48 -1433
MRPS14 -1167
MRPL43 -1166
GADD45GIP1 -1070
MTRF1L -1020
MRPL28 -952
MRPL52 -902
MRPS2 -745
MRPS34 -707
MRPL13 -59
MRPL51 225
MRPL27 2243
CHCHD1 2292
MRPL55 2827
MRPL54 4384
MRPL17 5209
MRPS21 6413


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
370
set Eukaryotic Translation Elongation
setSize 93
pANOVA 1.38e-13
s.dist 0.444
p.adjustANOVA 1.69e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
EEF1A1 6039
RPL3 5742
RPL11 5732
RPL35A 5710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
EEF1A1 6039
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
EEF1A1P5 3740
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
RPL10A 2958
RPL13 2954
EEF1D 2886
RPL6 2763
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
RPL29 1947
RPL7A 1934
RPL23A 1679
RPL30 1532
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
EEF1B2 -274
RPL27 -372
RPS4Y1 -419
RPL14 -613
RPL26L1 -874
RPL7 -906
RPS28 -970
EEF2 -989
RPS25 -1388
RPL38 -1519
RPS13 -1540
RPL37A -2628
EEF1G -3374
EEF1A2 -4316
RPLP1 -4830
RPL3L -5273


Selenocysteine synthesis

Selenocysteine synthesis
1138
set Selenocysteine synthesis
setSize 92
pANOVA 1.9e-13
s.dist 0.444
p.adjustANOVA 1.98e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
RPL23 3461
RPSA 3455
RPL9 3382
SARS1 3369
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
SECISBP2 2008
RPL29 1947
RPL7A 1934
RPL23A 1679
RPL30 1532
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
PSTK 196
RPL22 85
RPL27 -372
RPS4Y1 -419
EEFSEC -570
RPL14 -613
RPL26L1 -874
RPL7 -906
RPS28 -970
SEPHS2 -1057
RPS25 -1388
RPL38 -1519
RPS13 -1540
RPL37A -2628
SEPSECS -3642
RPLP1 -4830
RPL3L -5273


Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis
190
set Chondroitin sulfate biosynthesis
setSize 16
pANOVA 0.00218
s.dist 0.442
p.adjustANOVA 0.0155



Top enriched genes

Top 20 genes
GeneID Gene Rank
BGN 7799
CSGALNACT2 7599
CHPF2 7050
CHST11 5074
CHSY1 4902
CHPF 4822
CHST15 4491
CHST13 4175
CSGALNACT1 3175
CSPG4 2647
CHST3 2577
DCN 1698
CHSY3 972
CHST12 723
VCAN 398
CHST7 -4819

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BGN 7799
CSGALNACT2 7599
CHPF2 7050
CHST11 5074
CHSY1 4902
CHPF 4822
CHST15 4491
CHST13 4175
CSGALNACT1 3175
CSPG4 2647
CHST3 2577
DCN 1698
CHSY3 972
CHST12 723
VCAN 398
CHST7 -4819


Chondroitin sulfate/dermatan sulfate metabolism

Chondroitin sulfate/dermatan sulfate metabolism
191
set Chondroitin sulfate/dermatan sulfate metabolism
setSize 42
pANOVA 7.19e-07
s.dist 0.442
p.adjustANOVA 2.1e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
DSE 7910
BGN 7799
DSEL 7746
CSGALNACT2 7599
B4GALT7 7535
XYLT1 7457
CHPF2 7050
XYLT2 6869
GPC6 6867
IDS 6796
HEXB 6467
SDC2 6020
B3GAT3 5845
B3GALT6 5813
CHST14 5791
IDUA 5436
UST 5431
SDC1 5346
CHST11 5074
CHSY1 4902

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DSE 7910
BGN 7799
DSEL 7746
CSGALNACT2 7599
B4GALT7 7535
XYLT1 7457
CHPF2 7050
XYLT2 6869
GPC6 6867
IDS 6796
HEXB 6467
SDC2 6020
B3GAT3 5845
B3GALT6 5813
CHST14 5791
IDUA 5436
UST 5431
SDC1 5346
CHST11 5074
CHSY1 4902
CHPF 4822
HEXA 4725
CHST15 4491
CHST13 4175
ARSB 3440
CSGALNACT1 3175
CSPG4 2647
CHST3 2577
SDC3 1936
GPC2 1806
DCN 1698
SDC4 1151
CHSY3 972
CHST12 723
HYAL1 521
VCAN 398
GPC4 -2813
GPC3 -3758
HSPG2 -4446
CHST7 -4819
AGRN -5855
GPC1 -7876


RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases
931
set RHO GTPases Activate NADPH Oxidases
setSize 21
pANOVA 0.000456
s.dist 0.442
p.adjustANOVA 0.00445



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKCZ 7928
PRKCB 7615
PRKCD 7197
NCF2 7189
RAC2 7074
PRKCA 7057
NCF1 6565
CYBA 6403
NOXA1 6339
NCF4 6036
S100A9 5226
CYBB 4978
PIK3C3 3898
S100A8 2938
PIN1 1690
RAC1 556
MAPK3 -1891
MAPK1 -1971
PIK3R4 -3203
MAPK14 -3390

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKCZ 7928
PRKCB 7615
PRKCD 7197
NCF2 7189
RAC2 7074
PRKCA 7057
NCF1 6565
CYBA 6403
NOXA1 6339
NCF4 6036
S100A9 5226
CYBB 4978
PIK3C3 3898
S100A8 2938
PIN1 1690
RAC1 556
MAPK3 -1891
MAPK1 -1971
PIK3R4 -3203
MAPK14 -3390
MAPK11 -8438


Mitochondrial translation initiation

Mitochondrial translation initiation
706
set Mitochondrial translation initiation
setSize 88
pANOVA 8.62e-13
s.dist -0.441
p.adjustANOVA 7.01e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973
MRPL20 -5963

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973
MRPL20 -5963
MRPS31 -5954
MRPS18C -5838
MRPS26 -5716
MRPL3 -5675
MRPS17 -5651
MRPS11 -5596
MRPL18 -5573
MRPL37 -5572
MRPL44 -5487
MRPL35 -5439
MRPL50 -5363
MRPL30 -5359
MRPS24 -5350
AURKAIP1 -5304
MRPL14 -5269
MRPL45 -5223
MRPL22 -5216
MRPS6 -5136
MRPS30 -5123
MRPL2 -5032
MTIF2 -5009
MRPL40 -4980
MRPL38 -4809
MRPL34 -4734
MRPL41 -4717
MRPS12 -4632
MRPL58 -4545
MRPL24 -4399
MRPS33 -4278
MRPL16 -4251
MRPL42 -4233
OXA1L -4228
MTFMT -4136
MRPS16 -4129
MRPL10 -4126
PTCD3 -4113
MRPL11 -3982
MTIF3 -3945
MRPL23 -3939
DAP3 -3911
MRPL49 -3851
MRPL21 -3712
MRPL53 -3603
MRPL57 -3417
MRPL47 -3400
MRPL36 -3098
MRPL4 -3008
MRPS25 -2993
MRPS36 -2689
MRPL32 -2344
MRPS5 -1867
MRPL9 -1438
MRPL48 -1433
MRPS14 -1167
MRPL43 -1166
GADD45GIP1 -1070
MRPL28 -952
MRPL52 -902
MRPS2 -745
MRPS34 -707
MRPL13 -59
MRPL51 225
MRPL27 2243
CHCHD1 2292
MRPL55 2827
MRPL54 4384
MRPL17 5209
MRPS21 6413


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1118
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 1.3e-15
s.dist 0.439
p.adjustANOVA 2.72e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
SEC61B 7425
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
SSR4 6654
SSR2 6611
SEC61A1 6582
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
SSR3 6421
SSR1 6352

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
SEC61B 7425
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
SSR4 6654
SSR2 6611
SEC61A1 6582
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
SSR3 6421
SSR1 6352
RPL18A 6336
RPL31 6301
SEC61G 5831
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
DDOST 5308
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPN1 5152
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPN2 4797
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
SEC11A 4466
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
SPCS2 3685
SRPRB 3477
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
TRAM1 3060
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
SRP54 2534
RPS24 2481
RPS14 2363
RPL29 1947
RPL7A 1934
RPL23A 1679
SRP72 1657
SRPRA 1535
RPL30 1532
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
SEC11C -80
SPCS3 -321
RPL27 -372
RPS4Y1 -419
RPL14 -613
RPL26L1 -874
SRP14 -890
RPL7 -906
RPS28 -970
RPS25 -1388
RPL38 -1519
RPS13 -1540
RPL37A -2628
SPCS1 -2638
SRP68 -3927
SRP19 -4015
SEC61A2 -4264
RPLP1 -4830
RPL3L -5273
SRP9 -6551


Mitochondrial translation termination

Mitochondrial translation termination
707
set Mitochondrial translation termination
setSize 88
pANOVA 1.47e-12
s.dist -0.436
p.adjustANOVA 1.13e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973
MRPL20 -5963

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL39 -8062
MRPS35 -7723
MRPS9 -7370
MRPS18A -7057
MRPL46 -7020
MRPS10 -6921
MRPS18B -6799
MRPL33 -6791
MRPS28 -6630
MRPS7 -6497
MRPL1 -6475
MRPS15 -6465
MRPS27 -6387
MRPL12 -6236
MRPL19 -6234
MRPL15 -6147
MRPS23 -6094
ERAL1 -6048
MRPS22 -5973
MRPL20 -5963
MRPS31 -5954
MRPS18C -5838
MRPS26 -5716
MRPL3 -5675
MRPS17 -5651
MRPS11 -5596
MRPL18 -5573
MRPL37 -5572
MRPL44 -5487
MRPL35 -5439
GFM2 -5408
MRPL50 -5363
MRPL30 -5359
MRPS24 -5350
AURKAIP1 -5304
MRPL14 -5269
MRPL45 -5223
MRPL22 -5216
MRPS6 -5136
MRPS30 -5123
MRPL2 -5032
MRPL40 -4980
MRPL38 -4809
MRPL34 -4734
MRPL41 -4717
MRPS12 -4632
MRPL58 -4545
MRPL24 -4399
MRPS33 -4278
MRPL16 -4251
MRPL42 -4233
OXA1L -4228
MRPS16 -4129
MRPL10 -4126
PTCD3 -4113
MRPL11 -3982
MRPL23 -3939
DAP3 -3911
MRPL49 -3851
MRPL21 -3712
MRPL53 -3603
MRPL57 -3417
MRPL47 -3400
MRRF -3378
MRPL36 -3098
MRPL4 -3008
MRPS25 -2993
MRPS36 -2689
MRPL32 -2344
MRPS5 -1867
MRPL9 -1438
MRPL48 -1433
MRPS14 -1167
MRPL43 -1166
GADD45GIP1 -1070
MTRF1L -1020
MRPL28 -952
MRPL52 -902
MRPS2 -745
MRPS34 -707
MRPL13 -59
MRPL51 225
MRPL27 2243
CHCHD1 2292
MRPL55 2827
MRPL54 4384
MRPL17 5209
MRPS21 6413


The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport
1326
set The citric acid (TCA) cycle and respiratory electron transport
setSize 160
pANOVA 2.77e-21
s.dist -0.434
p.adjustANOVA 4.05e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFAF5 -8494
CYCS -7721
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA4 -7079
OGDH -7041
UCP3 -7005
MDH2 -6982
NDUFA5 -6949
PDHX -6946
UQCRFS1 -6912
SUCLA2 -6905
COX5A -6864
GLO1 -6846
PDHB -6842
NDUFAF6 -6817
ATP5F1B -6804
COX11 -6798
NDUFS3 -6796

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFAF5 -8494
CYCS -7721
NDUFV2 -7654
NDUFB9 -7642
NDUFA9 -7292
NDUFA4 -7079
OGDH -7041
UCP3 -7005
MDH2 -6982
NDUFA5 -6949
PDHX -6946
UQCRFS1 -6912
SUCLA2 -6905
COX5A -6864
GLO1 -6846
PDHB -6842
NDUFAF6 -6817
ATP5F1B -6804
COX11 -6798
NDUFS3 -6796
NDUFAB1 -6767
IDH2 -6714
LDHB -6653
CYC1 -6586
UQCR10 -6554
MPC2 -6553
NDUFA7 -6529
ATP5F1A -6528
NDUFS1 -6499
SDHD -6432
CS -6430
SDHA -6420
HAGH -6394
ACO2 -6392
NNT -6385
DLAT -6378
ATP5F1C -6348
ATP5F1D -6338
UQCRC2 -6331
PDK2 -6328
COX6C -6312
NDUFA12 -6301
NDUFB5 -6298
COX8A -6273
IDH3B -6239
MPC1 -6216
NDUFAF4 -6214
NDUFB10 -6208
COQ10A -6186
SUCLG2 -6161
ATP5PF -6158
GSTZ1 -6027
COX7B -6024
NDUFS2 -5996
FH -5919
L2HGDH -5918
UQCRC1 -5863
NDUFA8 -5850
VDAC1 -5818
TACO1 -5802
NDUFC1 -5771
SDHB -5708
TIMMDC1 -5690
DMAC2L -5620
ATP5MC3 -5610
ATP5MC1 -5597
SUCLG1 -5586
ATP5PB -5580
DLD -5578
NDUFS4 -5557
ETFA -5555
COX14 -5546
NDUFS7 -5537
ATP5MC2 -5482
TRAP1 -5472
NDUFS8 -5458
IDH3A -5422
ECSIT -5411
ADHFE1 -5381
COX5B -5370
UQCRB -5317
ATP5PO -5284
NDUFC2 -5279
NDUFB1 -5275
COX7C -5222
NDUFB6 -5204
PDP2 -5084
NDUFB7 -5070
NDUFAF1 -5064
UQCR11 -5049
NDUFB3 -4784
SLC25A27 -4759
NDUFA10 -4739
UQCRQ -4697
NDUFV1 -4619
PDHA1 -4601
COA1 -4600
NDUFB4 -4597
NDUFB8 -4561
NDUFA6 -4515
LRPPRC -4508
NDUFB11 -4493
DLST -4465
COX4I1 -4408
NDUFV3 -4345
NDUFA2 -4262
NDUFAF2 -4182
COX16 -3962
NDUFS6 -3885
NDUFB2 -3823
SDHC -3815
UQCRH -3376
TMEM186 -3335
ATP5MG -3234
ETFB -3229
FAHD1 -3182
ATP5PD -3034
COX6B1 -2908
ETFDH -2726
SCO1 -2624
TMEM126B -2352
NDUFS5 -2177
ME2 -2069
NDUFA1 -1919
PDP1 -1602
COX20 -1575
ME1 -1531
ATP5MF -1412
PDK4 -1256
COX18 -1165
ME3 -1127
COQ10B -1031
NDUFAF3 -1022
NDUFA13 -825
NUBPL -769
NDUFA3 -741
RXRA -556
SURF1 -319
IDH3G 163
UCP2 308
NDUFAF7 330
NDUFA11 795
ATP5F1E 1090
SLC16A8 1256
ATP5ME 1430
COX7A2L 1828
PDPR 1965
ACAD9 2687
SLC25A14 3153
D2HGDH 3536
PDK3 3810
COX19 3870
BSG 4281
LDHA 4661
SLC16A1 6022
COX6A1 6696
PPARD 7273
SCO2 7410
SLC16A3 7482
PDK1 7722


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
781
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 3.63e-13
s.dist 0.434
p.adjustANOVA 3.54e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
UPF1 7548
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
PABPC1 5877
RPL3 5742
RPL11 5732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
UPF1 7548
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
PABPC1 5877
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
RPL29 1947
RPL7A 1934
NCBP2 1768
RPL23A 1679
RPL30 1532
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
RPL27 -372
RPS4Y1 -419
RPL14 -613
NCBP1 -839
RPL26L1 -874
RPL7 -906
RPS28 -970
GSPT2 -1086
RPS25 -1388
RPL38 -1519
RPS13 -1540
RPL37A -2628
ETF1 -2777
RPLP1 -4830
EIF4G1 -5063
RPL3L -5273
GSPT1 -6198


Eukaryotic Translation Termination

Eukaryotic Translation Termination
372
set Eukaryotic Translation Termination
setSize 92
pANOVA 6.46e-13
s.dist 0.434
p.adjustANOVA 5.56e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
TRMT112 3647
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
RPL29 1947
RPL7A 1934
RPL23A 1679
RPL30 1532
RPL24 1202
RPS15A 1135
N6AMT1 1107
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
RPL27 -372
RPS4Y1 -419
RPL14 -613
RPL26L1 -874
RPL7 -906
RPS28 -970
GSPT2 -1086
RPS25 -1388
RPL38 -1519
RPS13 -1540
APEH -1940
RPL37A -2628
ETF1 -2777
RPLP1 -4830
RPL3L -5273
GSPT1 -6198


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1079
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 6.81e-14
s.dist 0.433
p.adjustANOVA 9.96e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS21 7721
RPL36 7661
RPS17 7247
RPS27 7112
RPL28 7035
RPL17 7027
RPS19 6965
RPL39 6814
RPL34 6686
RPS27L 6659
RPS15 6574
RPL35 6516
RPL39L 6493
RPL8 6453
RPL18A 6336
RPL31 6301
RPL3 5742
RPL11 5732
RPL35A 5710
RPS9 5706
RPL18 5502
RPS8 5435
EIF2AK4 5393
RPL10 5312
UBA52 5296
RPL5 5245
RPL12 5233
RPS10 5228
RPL37 5189
RPL22L1 5028
RPL13A 5015
FAU 5014
RPL19 4918
RPL26 4883
TRIB3 4869
DDIT3 4840
RPS2 4712
RPS6 4687
RPL15 4656
RPL36A 4635
EIF2S3 4590
RPS20 4577
RPS5 4421
RPL27A 4415
RPL21 4401
CEBPB 4399
RPLP2 4367
RPS11 4336
RPL41 4334
RPS29 4087
RPS12 4051
RPL32 4031
RPS27A 4009
RPS3 3802
ASNS 3748
RPL23 3461
RPSA 3455
RPL9 3382
RPS4X 3357
RPS3A 3340
RPLP0 3301
RPL36AL 3242
RPS18 3231
ATF3 3099
RPL10A 2958
RPL13 2954
RPL6 2763
RPS26 2722
RPS7 2700
RPS24 2481
RPS14 2363
GCN1 2115
RPL29 1947
RPL7A 1934
RPL23A 1679
RPL30 1532
ATF4 1221
RPL24 1202
RPS15A 1135
RPS23 1051
RPS16 948
RPL4 222
RPL22 85
RPL27 -372
RPS4Y1 -419
RPL14 -613
RPL26L1 -874
RPL7 -906
EIF2S2 -939
RPS28 -970
RPS25 -1388
RPL38 -1519
RPS13 -1540
ATF2 -1923
IMPACT -2124
RPL37A -2628
EIF2S1 -3565
RPLP1 -4830
RPL3L -5273
CEBPG -7396


Gap junction degradation

Gap junction degradation
463
set Gap junction degradation
setSize 12
pANOVA 0.0101
s.dist 0.429
p.adjustANOVA 0.0523



Top enriched genes

Top 20 genes
GeneID Gene Rank
GJA1 7683
DNM1 6958
ACTG1 6850
ACTB 5585
AP2M1 5465
DAB2 5212
CLTC 5021
CLTA 4648
DNM2 1903
MYO6 1194
CLTB -4940
CLTCL1 -6970

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GJA1 7683
DNM1 6958
ACTG1 6850
ACTB 5585
AP2M1 5465
DAB2 5212
CLTC 5021
CLTA 4648
DNM2 1903
MYO6 1194
CLTB -4940
CLTCL1 -6970


Signal regulatory protein family interactions

Signal regulatory protein family interactions
1155
set Signal regulatory protein family interactions
setSize 11
pANOVA 0.0143
s.dist 0.427
p.adjustANOVA 0.0686



Top enriched genes

Top 20 genes
GeneID Gene Rank
SRC 6997
TYROBP 6477
SIRPA 6349
PTPN6 6298
GRB2 6159
CD47 4662
PTK2B 4542
SIRPB1 4043
SKAP2 158
PTPN11 -3121
PTK2 -7373

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SRC 6997
TYROBP 6477
SIRPA 6349
PTPN6 6298
GRB2 6159
CD47 4662
PTK2B 4542
SIRPB1 4043
SKAP2 158
PTPN11 -3121
PTK2 -7373


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               cachem_1.0.8            zlibbioc_1.48.0        
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] yaml_2.3.8              rstudioapi_0.15.0       abind_1.4-5            
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report