Mitch Report

date generated: 2024-03-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	-0.7235362
7SK	0.0792128
A1BG	-0.8697311
A1BG.AS1	0.2565051
A2M	1.2525086
A2M.AS1	0.8703520

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2612
num_genes_in_profile	16514
duplicated_genes_present	0
num_profile_genes_in_sets	8299
num_profile_genes_not_in_sets	8215

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2612
num_genesets_excluded	1149
num_genesets_included	1463

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pANOVA	s.dist	p.adjustANOVA
Cohesin Loading onto Chromatin	10	1.15e-05	-0.801	1.07e-04
Formation of the ternary complex, and subsequently, the 43S complex	51	7.71e-22	-0.777	2.82e-20
Formation of a pool of free 40S subunits	100	1.03e-37	-0.742	2.16e-35
SARS-CoV-1 modulates host translation machinery	36	2.55e-14	-0.733	6.92e-13
Ribosomal scanning and start codon recognition	58	8.19e-22	-0.728	2.92e-20
Viral mRNA Translation	88	5.17e-32	-0.725	4.45e-30
Peptide chain elongation	88	1.09e-31	-0.721	8.00e-30
GTP hydrolysis and joining of the 60S ribosomal subunit	111	2.30e-39	-0.720	1.12e-36
Translation initiation complex formation	58	3.70e-21	-0.716	1.26e-19
Selenocysteine synthesis	92	2.02e-32	-0.714	1.97e-30
L13a-mediated translational silencing of Ceruloplasmin expression	110	2.41e-38	-0.713	5.89e-36
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	3.17e-21	-0.711	1.10e-19
Eukaryotic Translation Termination	92	4.28e-32	-0.710	3.92e-30
Eukaryotic Translation Elongation	93	8.51e-32	-0.703	6.56e-30
Establishment of Sister Chromatid Cohesion	10	1.23e-04	-0.701	8.41e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	2.21e-31	-0.695	1.54e-29
Cap-dependent Translation Initiation	118	2.18e-38	-0.689	5.89e-36
Eukaryotic Translation Initiation	118	2.18e-38	-0.689	5.89e-36
PINK1-PRKN Mediated Mitophagy	21	7.32e-08	-0.678	1.12e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	5.41e-31	-0.669	3.44e-29
Expression and translocation of olfactory receptors	25	1.03e-08	0.661	1.81e-07
SARS-CoV-2 modulates host translation machinery	49	3.30e-15	-0.650	9.10e-14
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.22e-32	-0.644	1.28e-30
Nonsense-Mediated Decay (NMD)	114	1.22e-32	-0.644	1.28e-30
Selenoamino acid metabolism	114	8.23e-32	-0.636	6.56e-30
SRP-dependent cotranslational protein targeting to membrane	111	2.59e-30	-0.628	1.58e-28
Mitophagy	28	1.50e-08	-0.618	2.53e-07
Common Pathway of Fibrin Clot Formation	11	4.86e-04	0.607	2.66e-03
Formation of ATP by chemiosmotic coupling	16	3.99e-05	-0.593	3.01e-04
Regulation of FOXO transcriptional activity by acetylation	10	1.17e-03	-0.593	5.58e-03
Olfactory Signaling Pathway	29	3.34e-08	0.592	5.26e-07
Influenza Viral RNA Transcription and Replication	135	4.32e-30	-0.568	2.53e-28
Cellular response to starvation	148	2.33e-31	-0.554	1.55e-29
Translation	292	1.17e-59	-0.553	8.54e-57
Cristae formation	29	4.03e-07	-0.544	5.61e-06
Complex I biogenesis	51	2.08e-11	-0.542	4.68e-10
Respiratory electron transport	93	3.66e-19	-0.537	1.22e-17
Receptor Mediated Mitophagy	11	2.12e-03	-0.535	8.88e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	1.39e-22	-0.532	5.37e-21
Mitochondrial translation	94	5.59e-19	-0.531	1.82e-17
Mitochondrial translation termination	88	8.14e-18	-0.530	2.53e-16
Mitochondrial translation elongation	88	1.10e-17	-0.528	3.36e-16
Mitochondrial translation initiation	88	1.13e-17	-0.528	3.37e-16
Influenza Infection	154	3.36e-29	-0.523	1.76e-27
Formation of Fibrin Clot (Clotting Cascade)	20	5.36e-05	0.522	3.94e-04
Branched-chain amino acid catabolism	21	3.89e-05	-0.519	2.95e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	1.96e-03	-0.516	8.34e-03
Beta-catenin phosphorylation cascade	17	2.42e-04	-0.514	1.46e-03
Regulation of expression of SLITs and ROBOs	162	1.86e-29	-0.513	1.01e-27
Laminin interactions	30	1.54e-06	0.507	1.94e-05

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Cohesin Loading onto Chromatin	10	1.15e-05	-0.801000	1.07e-04
Formation of the ternary complex, and subsequently, the 43S complex	51	7.71e-22	-0.777000	2.82e-20
Formation of a pool of free 40S subunits	100	1.03e-37	-0.742000	2.16e-35
SARS-CoV-1 modulates host translation machinery	36	2.55e-14	-0.733000	6.92e-13
Ribosomal scanning and start codon recognition	58	8.19e-22	-0.728000	2.92e-20
Viral mRNA Translation	88	5.17e-32	-0.725000	4.45e-30
Peptide chain elongation	88	1.09e-31	-0.721000	8.00e-30
GTP hydrolysis and joining of the 60S ribosomal subunit	111	2.30e-39	-0.720000	1.12e-36
Translation initiation complex formation	58	3.70e-21	-0.716000	1.26e-19
Selenocysteine synthesis	92	2.02e-32	-0.714000	1.97e-30
L13a-mediated translational silencing of Ceruloplasmin expression	110	2.41e-38	-0.713000	5.89e-36
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	3.17e-21	-0.711000	1.10e-19
Eukaryotic Translation Termination	92	4.28e-32	-0.710000	3.92e-30
Eukaryotic Translation Elongation	93	8.51e-32	-0.703000	6.56e-30
Establishment of Sister Chromatid Cohesion	10	1.23e-04	-0.701000	8.41e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	2.21e-31	-0.695000	1.54e-29
Cap-dependent Translation Initiation	118	2.18e-38	-0.689000	5.89e-36
Eukaryotic Translation Initiation	118	2.18e-38	-0.689000	5.89e-36
PINK1-PRKN Mediated Mitophagy	21	7.32e-08	-0.678000	1.12e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	5.41e-31	-0.669000	3.44e-29
Expression and translocation of olfactory receptors	25	1.03e-08	0.661000	1.81e-07
SARS-CoV-2 modulates host translation machinery	49	3.30e-15	-0.650000	9.10e-14
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.22e-32	-0.644000	1.28e-30
Nonsense-Mediated Decay (NMD)	114	1.22e-32	-0.644000	1.28e-30
Selenoamino acid metabolism	114	8.23e-32	-0.636000	6.56e-30
SRP-dependent cotranslational protein targeting to membrane	111	2.59e-30	-0.628000	1.58e-28
Mitophagy	28	1.50e-08	-0.618000	2.53e-07
Common Pathway of Fibrin Clot Formation	11	4.86e-04	0.607000	2.66e-03
Formation of ATP by chemiosmotic coupling	16	3.99e-05	-0.593000	3.01e-04
Regulation of FOXO transcriptional activity by acetylation	10	1.17e-03	-0.593000	5.58e-03
Olfactory Signaling Pathway	29	3.34e-08	0.592000	5.26e-07
Influenza Viral RNA Transcription and Replication	135	4.32e-30	-0.568000	2.53e-28
Cellular response to starvation	148	2.33e-31	-0.554000	1.55e-29
Translation	292	1.17e-59	-0.553000	8.54e-57
Cristae formation	29	4.03e-07	-0.544000	5.61e-06
Complex I biogenesis	51	2.08e-11	-0.542000	4.68e-10
Respiratory electron transport	93	3.66e-19	-0.537000	1.22e-17
Receptor Mediated Mitophagy	11	2.12e-03	-0.535000	8.88e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	1.39e-22	-0.532000	5.37e-21
Mitochondrial translation	94	5.59e-19	-0.531000	1.82e-17
Mitochondrial translation termination	88	8.14e-18	-0.530000	2.53e-16
Mitochondrial translation elongation	88	1.10e-17	-0.528000	3.36e-16
Mitochondrial translation initiation	88	1.13e-17	-0.528000	3.37e-16
Influenza Infection	154	3.36e-29	-0.523000	1.76e-27
Formation of Fibrin Clot (Clotting Cascade)	20	5.36e-05	0.522000	3.94e-04
Branched-chain amino acid catabolism	21	3.89e-05	-0.519000	2.95e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	1.96e-03	-0.516000	8.34e-03
Beta-catenin phosphorylation cascade	17	2.42e-04	-0.514000	1.46e-03
Regulation of expression of SLITs and ROBOs	162	1.86e-29	-0.513000	1.01e-27
Laminin interactions	30	1.54e-06	0.507000	1.94e-05
APC truncation mutants have impaired AXIN binding	14	1.27e-03	-0.497000	5.82e-03
AXIN missense mutants destabilize the destruction complex	14	1.27e-03	-0.497000	5.82e-03
Signaling by AMER1 mutants	14	1.27e-03	-0.497000	5.82e-03
Signaling by APC mutants	14	1.27e-03	-0.497000	5.82e-03
Signaling by AXIN mutants	14	1.27e-03	-0.497000	5.82e-03
Truncations of AMER1 destabilize the destruction complex	14	1.27e-03	-0.497000	5.82e-03
cGMP effects	14	1.81e-03	0.481000	8.01e-03
CTNNB1 S33 mutants aren’t phosphorylated	15	1.28e-03	-0.480000	5.82e-03
CTNNB1 S37 mutants aren’t phosphorylated	15	1.28e-03	-0.480000	5.82e-03
CTNNB1 S45 mutants aren’t phosphorylated	15	1.28e-03	-0.480000	5.82e-03
CTNNB1 T41 mutants aren’t phosphorylated	15	1.28e-03	-0.480000	5.82e-03
Signaling by CTNNB1 phospho-site mutants	15	1.28e-03	-0.480000	5.82e-03
Signaling by GSK3beta mutants	15	1.28e-03	-0.480000	5.82e-03
The citric acid (TCA) cycle and respiratory electron transport	160	1.68e-25	-0.478000	7.01e-24
Mitochondrial Fatty Acid Beta-Oxidation	34	1.66e-06	-0.475000	2.04e-05
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	3.10e-03	-0.474000	1.25e-02
Mitotic Telophase/Cytokinesis	13	3.22e-03	-0.472000	1.29e-02
Eicosanoid ligand-binding receptors	13	3.37e-03	0.470000	1.33e-02
Major pathway of rRNA processing in the nucleolus and cytosol	180	1.80e-27	-0.469000	7.96e-26
Attenuation phase	23	1.03e-04	-0.468000	7.13e-04
HIV elongation arrest and recovery	32	4.99e-06	-0.466000	5.25e-05
Pausing and recovery of HIV elongation	32	4.99e-06	-0.466000	5.25e-05
TICAM1,TRAF6-dependent induction of TAK1 complex	11	7.73e-03	-0.464000	2.70e-02
Alpha-protein kinase 1 signaling pathway	11	7.79e-03	-0.463000	2.71e-02
rRNA processing in the nucleus and cytosol	190	3.19e-28	-0.463000	1.50e-26
NF-kB is activated and signals survival	13	3.83e-03	-0.463000	1.49e-02
Cytosolic tRNA aminoacylation	24	9.07e-05	-0.462000	6.35e-04
FOXO-mediated transcription of cell death genes	15	2.03e-03	-0.460000	8.54e-03
rRNA processing	200	7.53e-29	-0.457000	3.67e-27
Mitochondrial protein import	63	4.69e-10	-0.454000	9.40e-09
E3 ubiquitin ligases ubiquitinate target proteins	44	2.04e-07	-0.453000	2.95e-06
Regulation of BACH1 activity	11	9.45e-03	-0.452000	3.10e-02
mRNA Splicing	210	3.90e-29	-0.448000	1.97e-27
mRNA Splicing - Major Pathway	202	8.84e-28	-0.446000	4.04e-26
Citric acid cycle (TCA cycle)	22	3.01e-04	-0.445000	1.78e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	29	3.74e-05	-0.442000	2.86e-04
mRNA Splicing - Minor Pathway	50	8.36e-08	-0.438000	1.25e-06
Pausing and recovery of Tat-mediated HIV elongation	30	3.50e-05	-0.437000	2.74e-04
Tat-mediated HIV elongation arrest and recovery	30	3.50e-05	-0.437000	2.74e-04
Suppression of phagosomal maturation	13	6.66e-03	-0.435000	2.36e-02
Peroxisomal protein import	56	1.88e-08	-0.434000	3.12e-07
Formation of RNA Pol II elongation complex	56	2.00e-08	-0.434000	3.26e-07
RNA Polymerase II Transcription Elongation	56	2.00e-08	-0.434000	3.26e-07
Defective B3GALTL causes PpS	35	1.10e-05	0.429000	1.04e-04
tRNA Aminoacylation	42	1.79e-06	-0.426000	2.15e-05
Glyoxylate metabolism and glycine degradation	24	3.06e-04	-0.426000	1.79e-03
O-glycosylation of TSR domain-containing proteins	36	1.10e-05	0.423000	1.04e-04
Protein ubiquitination	63	6.81e-09	-0.422000	1.21e-07
Mitochondrial iron-sulfur cluster biogenesis	13	9.22e-03	-0.417000	3.06e-02
ERBB2 Activates PTK6 Signaling	11	1.66e-02	0.417000	4.81e-02
Crosslinking of collagen fibrils	18	2.39e-03	0.413000	9.98e-03
Adrenaline,noradrenaline inhibits insulin secretion	22	7.90e-04	0.413000	3.98e-03
Chaperone Mediated Autophagy	20	1.41e-03	-0.412000	6.34e-03
Abortive elongation of HIV-1 transcript in the absence of Tat	23	6.83e-04	-0.409000	3.52e-03
Protein localization	154	2.14e-18	-0.409000	6.80e-17
mRNA decay by 5’ to 3’ exoribonuclease	15	6.18e-03	-0.408000	2.23e-02
IRAK2 mediated activation of TAK1 complex	10	2.60e-02	-0.407000	6.95e-02
APC-Cdc20 mediated degradation of Nek2A	23	7.79e-04	-0.405000	3.95e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	2.68e-02	-0.405000	7.06e-02
Formation of HIV elongation complex in the absence of HIV Tat	44	3.60e-06	-0.404000	4.06e-05
Translesion synthesis by POLK	17	4.11e-03	-0.402000	1.57e-02
Translesion synthesis by REV1	16	6.08e-03	-0.396000	2.21e-02
Signaling by ROBO receptors	201	3.69e-22	-0.396000	1.38e-20
RORA activates gene expression	18	3.63e-03	-0.396000	1.42e-02
Processing of Capped Intron-Containing Pre-mRNA	278	9.22e-30	-0.395000	5.19e-28
Late endosomal microautophagy	31	1.49e-04	-0.394000	9.76e-04
Folding of actin by CCT/TriC	10	3.17e-02	-0.392000	8.01e-02
Membrane binding and targetting of GAG proteins	14	1.11e-02	-0.392000	3.53e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	1.11e-02	-0.392000	3.53e-02
HSF1 activation	26	5.69e-04	-0.390000	2.99e-03
Prolactin receptor signaling	10	3.30e-02	-0.389000	8.22e-02
Mitochondrial tRNA aminoacylation	21	2.02e-03	-0.389000	8.52e-03
VLDLR internalisation and degradation	15	9.34e-03	-0.388000	3.09e-02
Translesion synthesis by POLI	17	5.82e-03	-0.386000	2.14e-02
RNA Polymerase II Pre-transcription Events	77	5.37e-09	-0.385000	9.71e-08
mTORC1-mediated signalling	24	1.16e-03	-0.383000	5.52e-03
Processing of SMDT1	15	1.06e-02	-0.381000	3.40e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	19	4.16e-03	-0.380000	1.59e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	2.10e-05	-0.379000	1.73e-04
HIV Transcription Elongation	42	2.10e-05	-0.379000	1.73e-04
Tat-mediated elongation of the HIV-1 transcript	42	2.10e-05	-0.379000	1.73e-04
Metabolism of RNA	695	2.08e-64	-0.378000	3.04e-61
Endosomal Sorting Complex Required For Transport (ESCRT)	30	3.55e-04	-0.377000	2.02e-03
EPHA-mediated growth cone collapse	23	1.83e-03	0.375000	8.03e-03
SUMOylation of transcription cofactors	44	1.66e-05	-0.375000	1.43e-04
Cytoprotection by HMOX1	58	1.01e-06	-0.371000	1.35e-05
Methylation	12	2.61e-02	-0.371000	6.96e-02
APC/C:Cdc20 mediated degradation of Cyclin B	22	2.68e-03	-0.370000	1.10e-02
Formation of the Early Elongation Complex	33	2.58e-04	-0.368000	1.54e-03
Formation of the HIV-1 Early Elongation Complex	33	2.58e-04	-0.368000	1.54e-03
Peroxisomal lipid metabolism	25	1.48e-03	-0.367000	6.64e-03
SARS-CoV-1-host interactions	93	1.07e-09	-0.366000	2.08e-08
Metalloprotease DUBs	19	5.83e-03	-0.365000	2.14e-02
Pyruvate metabolism and Citric Acid (TCA) cycle	51	7.42e-06	-0.363000	7.44e-05
Cell-extracellular matrix interactions	18	8.10e-03	0.361000	2.78e-02
Pexophagy	11	3.94e-02	-0.359000	9.53e-02
Signaling by PDGFRA extracellular domain mutants	12	3.18e-02	-0.358000	8.01e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	3.18e-02	-0.358000	8.01e-02
Nitric oxide stimulates guanylate cyclase	18	8.65e-03	0.358000	2.91e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	21	4.71e-03	-0.356000	1.77e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	5.30e-02	-0.353000	1.22e-01
Assembly Of The HIV Virion	16	1.44e-02	-0.353000	4.32e-02
Autodegradation of Cdh1 by Cdh1:APC/C	63	1.27e-06	-0.353000	1.64e-05
Dectin-1 mediated noncanonical NF-kB signaling	58	3.44e-06	-0.352000	3.90e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	1.16e-05	-0.352000	1.07e-04
Transcription of the HIV genome	67	6.88e-07	-0.351000	9.32e-06
Interleukin-10 signaling	27	1.62e-03	0.351000	7.17e-03
Inactivation of APC/C via direct inhibition of the APC/C complex	19	8.24e-03	-0.350000	2.79e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	8.24e-03	-0.350000	2.79e-02
Metabolism of amino acids and derivatives	315	1.71e-26	-0.349000	7.36e-25
Degradation of the extracellular matrix	113	1.82e-10	0.347000	3.86e-09
Intrinsic Pathway of Fibrin Clot Formation	12	3.76e-02	0.347000	9.20e-02
Defective CFTR causes cystic fibrosis	57	6.33e-06	-0.346000	6.52e-05
Anchoring fibril formation	15	2.06e-02	0.345000	5.80e-02
Degradation of AXIN	53	1.38e-05	-0.345000	1.21e-04
Regulation of Complement cascade	30	1.08e-03	0.345000	5.16e-03
Peptide ligand-binding receptors	77	1.68e-07	0.345000	2.46e-06
NIK–>noncanonical NF-kB signaling	57	6.72e-06	-0.345000	6.87e-05
Elevation of cytosolic Ca2+ levels	13	3.14e-02	0.345000	8.00e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	3.16e-02	0.344000	8.00e-02
Defective EXT2 causes exostoses 2	13	3.16e-02	0.344000	8.00e-02
STAT3 nuclear events downstream of ALK signaling	10	5.94e-02	-0.344000	1.32e-01
Voltage gated Potassium channels	19	9.46e-03	0.344000	3.10e-02
Ubiquitin-dependent degradation of Cyclin D	50	2.61e-05	-0.344000	2.08e-04
Degradation of cysteine and homocysteine	14	2.60e-02	-0.344000	6.94e-02
HDMs demethylate histones	21	6.43e-03	-0.344000	2.31e-02
Regulation of Apoptosis	51	2.20e-05	-0.344000	1.80e-04
APC/C:Cdc20 mediated degradation of Securin	64	2.03e-06	-0.343000	2.39e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.53e-05	-0.343000	1.33e-04
Regulation of PTEN mRNA translation	11	4.88e-02	-0.343000	1.14e-01
Vpu mediated degradation of CD4	50	2.92e-05	-0.342000	2.31e-04
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	5.00e-02	-0.341000	1.17e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	23	4.64e-03	-0.341000	1.74e-02
NCAM1 interactions	32	8.47e-04	0.341000	4.24e-03
SLBP independent Processing of Histone Pre-mRNAs	10	6.24e-02	-0.340000	1.37e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	5.08e-02	-0.340000	1.17e-01
alpha-linolenic acid (ALA) metabolism	11	5.08e-02	-0.340000	1.17e-01
Basigin interactions	22	5.85e-03	0.339000	2.14e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	4.77e-05	-0.339000	3.53e-04
Receptor-type tyrosine-protein phosphatases	13	3.45e-02	0.339000	8.56e-02
Postmitotic nuclear pore complex (NPC) reformation	27	2.46e-03	-0.337000	1.02e-02
Early Phase of HIV Life Cycle	14	3.00e-02	-0.335000	7.77e-02
Association of TriC/CCT with target proteins during biosynthesis	34	7.50e-04	-0.334000	3.82e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	1.45e-02	-0.333000	4.32e-02
Diseases associated with O-glycosylation of proteins	54	2.40e-05	0.332000	1.95e-04
HIV Life Cycle	145	5.41e-12	-0.332000	1.34e-10
Vif-mediated degradation of APOBEC3G	52	3.86e-05	-0.330000	2.94e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	69	2.20e-06	-0.330000	2.56e-05
Class A/1 (Rhodopsin-like receptors)	141	1.48e-11	0.329000	3.38e-10
Negative regulation of NOTCH4 signaling	54	2.84e-05	-0.329000	2.26e-04
p75NTR signals via NF-kB	16	2.28e-02	-0.329000	6.25e-02
Macroautophagy	124	2.60e-10	-0.329000	5.35e-09
rRNA processing in the mitochondrion	10	7.28e-02	-0.328000	1.54e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	2.81e-02	-0.327000	7.38e-02
Phase 0 - rapid depolarisation	28	2.76e-03	0.327000	1.13e-02
Activation of Matrix Metalloproteinases	21	9.54e-03	0.327000	3.11e-02
Degradation of beta-catenin by the destruction complex	83	2.83e-07	-0.326000	4.02e-06
Late Phase of HIV Life Cycle	132	1.10e-10	-0.325000	2.41e-09
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	4.20e-05	-0.325000	3.15e-04
SHC-mediated cascade:FGFR4	13	4.40e-02	0.323000	1.04e-01
Dissolution of Fibrin Clot	11	6.53e-02	0.321000	1.43e-01
ABC transporter disorders	69	4.06e-06	-0.321000	4.47e-05
ERBB2 Regulates Cell Motility	13	4.52e-02	0.321000	1.07e-01
Autophagy	139	7.06e-11	-0.320000	1.57e-09
Regulation of PTEN stability and activity	67	5.87e-06	-0.320000	6.13e-05
Smooth Muscle Contraction	36	8.88e-04	0.320000	4.42e-03
Regulation of RUNX2 expression and activity	70	3.86e-06	-0.319000	4.28e-05
Mitochondrial calcium ion transport	22	9.63e-03	-0.319000	3.14e-02
HIV Infection	221	3.85e-16	-0.318000	1.08e-14
Downstream signaling events of B Cell Receptor (BCR)	78	1.24e-06	-0.318000	1.63e-05
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	9.87e-04	-0.317000	4.83e-03
Assembly of the pre-replicative complex	87	3.23e-07	-0.317000	4.55e-06
Other semaphorin interactions	19	1.69e-02	0.317000	4.86e-02
Hh mutants are degraded by ERAD	53	6.95e-05	-0.316000	4.92e-04
Circadian Clock	66	9.56e-06	-0.315000	9.33e-05
Mitochondrial biogenesis	87	4.26e-07	-0.314000	5.88e-06
Formation of Incision Complex in GG-NER	43	3.75e-04	-0.314000	2.11e-03
Deadenylation-dependent mRNA decay	50	1.27e-04	-0.313000	8.60e-04
Activation of NF-kappaB in B cells	65	1.29e-05	-0.313000	1.15e-04
Translesion Synthesis by POLH	18	2.16e-02	-0.313000	6.04e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	1.63e-04	-0.311000	1.05e-03
p53-Independent DNA Damage Response	49	1.63e-04	-0.311000	1.05e-03
p53-Independent G1/S DNA damage checkpoint	49	1.63e-04	-0.311000	1.05e-03
Molecules associated with elastic fibres	33	1.98e-03	0.311000	8.40e-03
Downstream TCR signaling	80	1.50e-06	-0.311000	1.93e-05
Collagen degradation	55	6.96e-05	0.310000	4.92e-04
Josephin domain DUBs	10	9.05e-02	-0.309000	1.82e-01
Complement cascade	34	1.82e-03	0.309000	8.01e-03
Amino acids regulate mTORC1	48	2.14e-04	-0.309000	1.32e-03
Sema4D induced cell migration and growth-cone collapse	20	1.68e-02	0.309000	4.86e-02
SARS-CoV-1 Infection	135	5.94e-10	-0.309000	1.18e-08
Autodegradation of the E3 ubiquitin ligase COP1	49	1.86e-04	-0.309000	1.17e-03
GLI3 is processed to GLI3R by the proteasome	57	5.76e-05	-0.308000	4.21e-04
Budding and maturation of HIV virion	27	5.65e-03	-0.308000	2.08e-02
CDK-mediated phosphorylation and removal of Cdc6	68	1.19e-05	-0.307000	1.09e-04
RHO GTPases activate CIT	18	2.41e-02	0.307000	6.53e-02
mRNA 3’-end processing	57	6.31e-05	-0.306000	4.57e-04
RNA Polymerase II Transcription Termination	66	1.68e-05	-0.306000	1.43e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	68	1.26e-05	-0.306000	1.13e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	68	1.26e-05	-0.306000	1.13e-04
SCF-beta-TrCP mediated degradation of Emi1	52	1.37e-04	-0.306000	9.22e-04
TP53 Regulates Transcription of DNA Repair Genes	61	3.72e-05	-0.305000	2.86e-04
TNFR1-induced NF-kappa-B signaling pathway	32	2.89e-03	-0.304000	1.17e-02
Metabolism of porphyrins	21	1.59e-02	-0.304000	4.68e-02
SARS-CoV-2 modulates autophagy	11	8.10e-02	-0.304000	1.69e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	2.20e-02	-0.304000	6.09e-02
Elastic fibre formation	40	9.12e-04	0.303000	4.49e-03
Deadenylation of mRNA	22	1.41e-02	-0.302000	4.23e-02
Detoxification of Reactive Oxygen Species	33	2.67e-03	-0.302000	1.10e-02
Heme signaling	44	5.29e-04	-0.302000	2.84e-03
Degradation of GLI2 by the proteasome	57	8.05e-05	-0.302000	5.66e-04
Interactions of Rev with host cellular proteins	37	1.50e-03	-0.302000	6.68e-03
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	44	5.37e-04	-0.302000	2.88e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.02e-05	-0.301000	9.71e-05
RNA Pol II CTD phosphorylation and interaction with CE	27	6.81e-03	-0.301000	2.41e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	6.81e-03	-0.301000	2.41e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	85	1.70e-06	0.300000	2.05e-05
SARS-CoV-2-host interactions	175	8.44e-12	-0.300000	2.06e-10
FGFR2 alternative splicing	24	1.12e-02	-0.299000	3.54e-02
Switching of origins to a post-replicative state	85	2.01e-06	-0.298000	2.39e-05
Signaling by cytosolic FGFR1 fusion mutants	18	2.89e-02	-0.298000	7.51e-02
Uptake and function of anthrax toxins	11	8.77e-02	-0.297000	1.77e-01
Cellular response to chemical stress	183	4.56e-12	-0.297000	1.15e-10
Collagen chain trimerization	41	1.02e-03	0.297000	4.96e-03
Cellular response to hypoxia	72	1.38e-05	-0.296000	1.21e-04
Host Interactions of HIV factors	125	1.12e-08	-0.296000	1.94e-07
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	4.09e-02	-0.295000	9.79e-02
Endogenous sterols	19	2.59e-02	-0.295000	6.94e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	7.95e-03	-0.295000	2.74e-02
LGI-ADAM interactions	11	9.31e-02	0.292000	1.86e-01
SUMOylation of RNA binding proteins	47	5.26e-04	-0.292000	2.84e-03
Metabolism of non-coding RNA	53	2.36e-04	-0.292000	1.43e-03
snRNP Assembly	53	2.36e-04	-0.292000	1.43e-03
SUMOylation of chromatin organization proteins	57	1.44e-04	-0.291000	9.60e-04
HSF1-dependent transactivation	33	3.85e-03	-0.291000	1.49e-02
TP53 Regulates Metabolic Genes	81	6.17e-06	-0.291000	6.40e-05
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	1.19e-02	-0.290000	3.70e-02
FCERI mediated NF-kB activation	79	8.21e-06	-0.290000	8.12e-05
HATs acetylate histones	84	4.33e-06	-0.290000	4.62e-05
Selective autophagy	72	2.16e-05	-0.290000	1.78e-04
Degradation of GLI1 by the proteasome	57	1.68e-04	-0.288000	1.08e-03
Cyclin E associated events during G1/S transition	80	8.58e-06	-0.288000	8.42e-05
Inactivation of CSF3 (G-CSF) signaling	25	1.28e-02	-0.288000	3.89e-02
DNA Double Strand Break Response	45	8.61e-04	-0.287000	4.30e-03
p130Cas linkage to MAPK signaling for integrins	12	8.52e-02	0.287000	1.74e-01
Cellular responses to stress	687	2.12e-37	-0.287000	3.88e-35
HCMV Late Events	60	1.26e-04	-0.286000	8.56e-04
Formation of TC-NER Pre-Incision Complex	53	3.13e-04	-0.286000	1.82e-03
NCAM signaling for neurite out-growth	52	3.60e-04	0.286000	2.04e-03
RHOBTB1 GTPase cycle	23	1.76e-02	-0.286000	5.04e-02
Adenylate cyclase inhibitory pathway	13	7.46e-02	0.286000	1.58e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	5.56e-02	-0.285000	1.27e-01
Regulation of signaling by CBL	22	2.06e-02	-0.285000	5.80e-02
CLEC7A (Dectin-1) signaling	95	1.59e-06	-0.285000	1.97e-05
Regulation of TP53 Activity through Acetylation	29	7.93e-03	-0.285000	2.74e-02
Pyruvate metabolism	27	1.06e-02	-0.284000	3.40e-02
mRNA Capping	29	8.10e-03	-0.284000	2.78e-02
Cellular responses to stimuli	694	7.54e-37	-0.283000	1.23e-34
SUMOylation of DNA damage response and repair proteins	77	1.75e-05	-0.283000	1.49e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	3.77e-03	-0.283000	1.47e-02
Post-translational protein phosphorylation	76	2.01e-05	0.283000	1.69e-04
Initial triggering of complement	17	4.36e-02	0.283000	1.04e-01
Diseases of mitotic cell cycle	35	3.89e-03	-0.282000	1.50e-02
Physiological factors	10	1.24e-01	-0.281000	2.32e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	1.06e-01	0.281000	2.07e-01
rRNA modification in the nucleus and cytosol	59	1.95e-04	-0.280000	1.22e-03
Hh mutants abrogate ligand secretion	55	3.28e-04	-0.280000	1.88e-03
Viral Infection Pathways	656	3.27e-34	-0.280000	4.79e-32
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	4.01e-02	-0.279000	9.66e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	6.10e-02	-0.279000	1.35e-01
Formation of the cornified envelope	22	2.33e-02	0.279000	6.36e-02
Keratinization	22	2.33e-02	0.279000	6.36e-02
Deactivation of the beta-catenin transactivating complex	39	2.57e-03	-0.279000	1.07e-02
Regulation of TNFR1 signaling	47	9.43e-04	-0.279000	4.63e-03
FGFR2 ligand binding and activation	10	1.27e-01	0.279000	2.36e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	8.20e-02	-0.279000	1.70e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	5.38e-02	-0.278000	1.23e-01
ER Quality Control Compartment (ERQC)	21	2.74e-02	-0.278000	7.21e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	87	7.83e-06	-0.277000	7.79e-05
Regulation of ornithine decarboxylase (ODC)	48	8.91e-04	-0.277000	4.42e-03
Cross-presentation of soluble exogenous antigens (endosomes)	46	1.18e-03	-0.277000	5.58e-03
APC/C:Cdc20 mediated degradation of mitotic proteins	70	6.50e-05	-0.276000	4.69e-04
S Phase	152	4.31e-09	-0.276000	7.95e-08
Synthesis of bile acids and bile salts	25	1.69e-02	-0.276000	4.86e-02
Potassium Channels	54	4.55e-04	0.276000	2.51e-03
Base-Excision Repair, AP Site Formation	23	2.22e-02	-0.275000	6.13e-02
Transport of Mature Transcript to Cytoplasm	81	1.86e-05	-0.275000	1.57e-04
Degradation of DVL	55	4.17e-04	-0.275000	2.32e-03
Assembly of collagen fibrils and other multimeric structures	57	3.28e-04	0.275000	1.88e-03
Regulation of NPAS4 gene expression	12	9.90e-02	-0.275000	1.96e-01
Metabolism of cofactors	18	4.36e-02	-0.275000	1.04e-01
Retrograde neurotrophin signalling	13	8.65e-02	-0.275000	1.76e-01
Chromatin modifying enzymes	205	1.44e-11	-0.274000	3.33e-10
Chromatin organization	205	1.44e-11	-0.274000	3.33e-10
TBC/RABGAPs	43	1.92e-03	-0.273000	8.24e-03
SCF(Skp2)-mediated degradation of p27/p21	58	3.22e-04	-0.273000	1.86e-03
Phosphorylation of the APC/C	19	3.94e-02	-0.273000	9.54e-02
SHC-mediated cascade:FGFR1	13	8.92e-02	0.272000	1.80e-01
SUMOylation of transcription factors	16	5.96e-02	-0.272000	1.33e-01
Downregulation of TGF-beta receptor signaling	26	1.66e-02	-0.272000	4.80e-02
Regulation of gene expression by Hypoxia-inducible Factor	10	1.38e-01	-0.271000	2.50e-01
NRIF signals cell death from the nucleus	16	6.08e-02	-0.271000	1.34e-01
MET activates PTK2 signaling	30	1.05e-02	0.270000	3.39e-02
Signaling by WNT in cancer	29	1.19e-02	-0.270000	3.70e-02
Protein methylation	15	7.06e-02	-0.270000	1.51e-01
RHO GTPases Activate NADPH Oxidases	21	3.25e-02	-0.270000	8.14e-02
Regulation of RUNX3 expression and activity	55	5.51e-04	-0.269000	2.92e-03
InlB-mediated entry of Listeria monocytogenes into host cell	13	9.37e-02	-0.269000	1.87e-01
DNA Replication Pre-Initiation	101	3.15e-06	-0.269000	3.60e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	2.06e-04	-0.268000	1.28e-03
Defective B3GAT3 causes JDSSDHD	16	6.33e-02	0.268000	1.39e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	71	9.43e-05	-0.268000	6.57e-04
Rev-mediated nuclear export of HIV RNA	35	6.09e-03	-0.268000	2.21e-02
Sulfur amino acid metabolism	25	2.04e-02	-0.268000	5.77e-02
Signaling by CSF3 (G-CSF)	30	1.11e-02	-0.268000	3.53e-02
HuR (ELAVL1) binds and stabilizes mRNA	10	1.43e-01	-0.268000	2.56e-01
HIV Transcription Initiation	45	1.91e-03	-0.268000	8.20e-03
RNA Polymerase II HIV Promoter Escape	45	1.91e-03	-0.268000	8.20e-03
RNA Polymerase II Promoter Escape	45	1.91e-03	-0.268000	8.20e-03
RNA Polymerase II Transcription Initiation	45	1.91e-03	-0.268000	8.20e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	1.91e-03	-0.268000	8.20e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	1.91e-03	-0.268000	8.20e-03
Orc1 removal from chromatin	66	1.73e-04	-0.267000	1.10e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.09e-01	0.267000	2.10e-01
Estrogen-dependent gene expression	92	1.00e-05	-0.267000	9.67e-05
Asymmetric localization of PCP proteins	61	3.22e-04	-0.266000	1.86e-03
Stabilization of p53	54	7.14e-04	-0.266000	3.67e-03
Hyaluronan metabolism	14	8.46e-02	0.266000	1.73e-01
Nuclear import of Rev protein	34	7.26e-03	-0.266000	2.55e-02
Metabolism of polyamines	56	5.79e-04	-0.266000	3.03e-03
COPII-mediated vesicle transport	63	2.64e-04	-0.266000	1.56e-03
Signaling by Retinoic Acid	35	6.65e-03	-0.265000	2.36e-02
Extracellular matrix organization	253	4.11e-13	0.265000	1.09e-11
Nuclear events mediated by NFE2L2	76	6.60e-05	-0.265000	4.74e-04
Chemokine receptors bind chemokines	30	1.22e-02	0.264000	3.75e-02
Integrin cell surface interactions	76	6.82e-05	0.264000	4.87e-04
Response of EIF2AK1 (HRI) to heme deficiency	14	8.72e-02	-0.264000	1.77e-01
Cyclin A:Cdk2-associated events at S phase entry	82	3.68e-05	-0.264000	2.85e-04
Transcriptional activation of mitochondrial biogenesis	50	1.27e-03	-0.264000	5.82e-03
Calnexin/calreticulin cycle	26	2.04e-02	-0.263000	5.77e-02
HS-GAG degradation	21	3.72e-02	0.263000	9.12e-02
TNFs bind their physiological receptors	18	5.38e-02	0.263000	1.23e-01
Interaction between L1 and Ankyrins	26	2.08e-02	0.262000	5.83e-02
Prefoldin mediated transfer of substrate to CCT/TriC	25	2.34e-02	-0.262000	6.37e-02
GPCR ligand binding	197	2.47e-10	0.262000	5.17e-09
SUMOylation of DNA replication proteins	44	2.76e-03	-0.261000	1.13e-02
Regulation of HSF1-mediated heat shock response	79	6.18e-05	-0.261000	4.50e-04
Presynaptic depolarization and calcium channel opening	10	1.54e-01	0.260000	2.69e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	1.36e-01	-0.259000	2.48e-01
PPARA activates gene expression	106	4.14e-06	-0.259000	4.51e-05
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	8.97e-04	-0.259000	4.43e-03
TNF signaling	56	8.45e-04	-0.258000	4.24e-03
Regulation of APC/C activators between G1/S and early anaphase	76	1.15e-04	-0.256000	7.93e-04
SUMO E3 ligases SUMOylate target proteins	159	2.84e-08	-0.255000	4.57e-07
G alpha (q) signalling events	128	6.51e-07	0.255000	8.90e-06
Acetylcholine Neurotransmitter Release Cycle	11	1.46e-01	0.253000	2.60e-01
tRNA processing in the nucleus	59	7.72e-04	-0.253000	3.92e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	12	1.30e-01	-0.253000	2.40e-01
Negative regulation of MET activity	19	5.73e-02	-0.252000	1.30e-01
Synthesis of DNA	112	4.16e-06	-0.252000	4.51e-05
Export of Viral Ribonucleoproteins from Nucleus	33	1.24e-02	-0.252000	3.80e-02
GABA receptor activation	39	6.58e-03	0.252000	2.35e-02
Interactions of Vpr with host cellular proteins	37	8.17e-03	-0.251000	2.78e-02
Vpr-mediated nuclear import of PICs	34	1.13e-02	-0.251000	3.54e-02
Cholesterol biosynthesis	27	2.39e-02	-0.251000	6.49e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	1.28e-02	-0.250000	3.89e-02
KEAP1-NFE2L2 pathway	101	1.38e-05	-0.250000	1.21e-04
Thrombin signalling through proteinase activated receptors (PARs)	25	3.03e-02	0.250000	7.79e-02
Retinoid metabolism and transport	29	1.98e-02	0.250000	5.64e-02
Aspartate and asparagine metabolism	10	1.71e-01	0.250000	2.91e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	2.48e-02	-0.250000	6.69e-02
ADP signalling through P2Y purinoceptor 12	14	1.06e-01	0.249000	2.07e-01
Nonhomologous End-Joining (NHEJ)	35	1.08e-02	-0.249000	3.45e-02
p75NTR recruits signalling complexes	13	1.21e-01	-0.249000	2.27e-01
Cellular response to heat stress	97	2.41e-05	-0.248000	1.95e-04
RHOBTB2 GTPase cycle	23	4.00e-02	-0.247000	9.63e-02
Formation of WDR5-containing histone-modifying complexes	42	5.56e-03	-0.247000	2.05e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	9.26e-03	-0.247000	3.07e-02
FLT3 Signaling	35	1.17e-02	-0.246000	3.63e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes	14	1.11e-01	-0.246000	2.13e-01
ABC-family proteins mediated transport	93	4.24e-05	-0.246000	3.16e-04
Transcription of E2F targets under negative control by DREAM complex	18	7.11e-02	-0.246000	1.52e-01
Cytosolic iron-sulfur cluster assembly	13	1.26e-01	-0.245000	2.35e-01
DNA Damage Recognition in GG-NER	38	8.97e-03	-0.245000	3.00e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	2.51e-02	-0.245000	6.75e-02
Chondroitin sulfate biosynthesis	15	1.01e-01	0.245000	1.99e-01
Regulation of lipid metabolism by PPARalpha	108	1.18e-05	-0.244000	1.08e-04
SUMOylation	165	6.57e-08	-0.244000	1.01e-06
APC/C-mediated degradation of cell cycle proteins	81	1.49e-04	-0.244000	9.76e-04
Regulation of mitotic cell cycle	81	1.49e-04	-0.244000	9.76e-04
Inhibition of DNA recombination at telomere	27	2.83e-02	-0.244000	7.41e-02
Prolonged ERK activation events	14	1.14e-01	-0.244000	2.18e-01
SUMOylation of SUMOylation proteins	35	1.27e-02	-0.243000	3.88e-02
P2Y receptors	10	1.83e-01	0.243000	3.05e-01
HDACs deacetylate histones	37	1.05e-02	-0.243000	3.38e-02
C-type lectin receptors (CLRs)	121	3.86e-06	-0.243000	4.28e-05
RHOBTB GTPase Cycle	35	1.29e-02	-0.243000	3.90e-02
Processing and activation of SUMO	10	1.85e-01	-0.242000	3.06e-01
Collagen formation	84	1.27e-04	0.242000	8.60e-04
MTOR signalling	41	7.36e-03	-0.242000	2.57e-02
Sema4D in semaphorin signaling	24	4.09e-02	0.241000	9.79e-02
Disorders of Developmental Biology	12	1.48e-01	-0.241000	2.63e-01
Disorders of Nervous System Development	12	1.48e-01	-0.241000	2.63e-01
Loss of function of MECP2 in Rett syndrome	12	1.48e-01	-0.241000	2.63e-01
Pervasive developmental disorders	12	1.48e-01	-0.241000	2.63e-01
Glycogen storage diseases	14	1.20e-01	-0.240000	2.26e-01
SUMOylation of DNA methylation proteins	16	9.64e-02	-0.240000	1.92e-01
Viral Messenger RNA Synthesis	44	5.91e-03	-0.240000	2.16e-02
PKMTs methylate histone lysines	42	7.25e-03	-0.240000	2.55e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity	31	2.10e-02	-0.239000	5.89e-02
DNA Replication	124	4.22e-06	-0.239000	4.54e-05
PTEN Regulation	138	1.25e-06	-0.239000	1.63e-05
Cleavage of the damaged pyrimidine	21	5.78e-02	-0.239000	1.30e-01
Depyrimidination	21	5.78e-02	-0.239000	1.30e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	21	5.78e-02	-0.239000	1.30e-01
Nucleotide Excision Repair	110	1.51e-05	-0.239000	1.31e-04
Signaling by BMP	24	4.29e-02	0.239000	1.02e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	1.96e-02	-0.238000	5.60e-02
Effects of PIP2 hydrolysis	23	4.80e-02	0.238000	1.13e-01
Diseases associated with N-glycosylation of proteins	20	6.57e-02	0.238000	1.43e-01
Epigenetic regulation of gene expression	133	2.24e-06	-0.238000	2.59e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	3.07e-04	-0.237000	1.79e-03
Glycolysis	65	9.97e-04	-0.236000	4.86e-03
Nucleotide-like (purinergic) receptors	14	1.27e-01	0.236000	2.36e-01
CLEC7A (Dectin-1) induces NFAT activation	11	1.77e-01	-0.235000	2.97e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	2.14e-02	-0.235000	6.00e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	28	3.15e-02	-0.235000	8.00e-02
Global Genome Nucleotide Excision Repair (GG-NER)	84	2.02e-04	-0.235000	1.25e-03
Long-term potentiation	19	7.67e-02	0.235000	1.62e-01
Vitamin B5 (pantothenate) metabolism	16	1.04e-01	-0.235000	2.04e-01
Synthesis of IP3 and IP4 in the cytosol	22	5.84e-02	0.233000	1.31e-01
Signaling by PDGFR in disease	20	7.16e-02	-0.233000	1.53e-01
Defective pyroptosis	20	7.17e-02	-0.233000	1.53e-01
IRAK1 recruits IKK complex	14	1.32e-01	-0.233000	2.43e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	1.32e-01	-0.233000	2.43e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	30	2.76e-02	0.232000	7.25e-02
Dual incision in TC-NER	65	1.20e-03	-0.232000	5.65e-03
Termination of translesion DNA synthesis	31	2.52e-02	-0.232000	6.76e-02
Platelet Adhesion to exposed collagen	11	1.83e-01	0.232000	3.04e-01
Norepinephrine Neurotransmitter Release Cycle	13	1.47e-01	0.232000	2.62e-01
Striated Muscle Contraction	35	1.77e-02	0.232000	5.08e-02
Hedgehog ligand biogenesis	60	1.94e-03	-0.231000	8.30e-03
Neurexins and neuroligins	39	1.25e-02	0.231000	3.81e-02
Phase 2 - plateau phase	11	1.84e-01	0.231000	3.06e-01
Signaling by the B Cell Receptor (BCR)	105	4.36e-05	-0.231000	3.24e-04
Synthesis of PIPs at the late endosome membrane	11	1.85e-01	-0.231000	3.06e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	1.10e-01	0.231000	2.12e-01
Gene Silencing by RNA	78	4.35e-04	-0.230000	2.41e-03
O-linked glycosylation	86	2.29e-04	0.230000	1.40e-03
Glycogen synthesis	13	1.51e-01	-0.230000	2.66e-01
Carnitine metabolism	14	1.37e-01	-0.230000	2.48e-01
Energy dependent regulation of mTOR by LKB1-AMPK	29	3.25e-02	-0.229000	8.14e-02
Dual Incision in GG-NER	41	1.13e-02	-0.229000	3.54e-02
Platelet Aggregation (Plug Formation)	30	3.05e-02	0.228000	7.79e-02
IKK complex recruitment mediated by RIP1	23	5.82e-02	-0.228000	1.31e-01
p53-Dependent G1 DNA Damage Response	61	2.06e-03	-0.228000	8.62e-03
p53-Dependent G1/S DNA damage checkpoint	61	2.06e-03	-0.228000	8.62e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	51	4.86e-03	-0.228000	1.81e-02
Non-integrin membrane-ECM interactions	57	2.92e-03	0.228000	1.18e-02
Negative regulation of FLT3	13	1.55e-01	-0.228000	2.71e-01
Meiotic synapsis	32	2.65e-02	-0.227000	7.01e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	1.17e-01	-0.226000	2.22e-01
SARS-CoV-2 Infection	262	3.61e-10	-0.225000	7.33e-09
Transcriptional regulation by small RNAs	54	4.26e-03	-0.225000	1.61e-02
SIRT1 negatively regulates rRNA expression	15	1.32e-01	-0.225000	2.43e-01
RNA polymerase II transcribes snRNA genes	71	1.07e-03	-0.225000	5.13e-03
The NLRP3 inflammasome	16	1.20e-01	-0.224000	2.27e-01
Defects in vitamin and cofactor metabolism	20	8.28e-02	-0.224000	1.71e-01
DNA Damage Bypass	45	9.34e-03	-0.224000	3.09e-02
Downstream signal transduction	28	4.05e-02	-0.224000	9.71e-02
Metabolism of folate and pterines	17	1.10e-01	-0.224000	2.12e-01
Adenylate cyclase activating pathway	10	2.21e-01	0.223000	3.51e-01
Regulation of RAS by GAPs	65	1.88e-03	-0.223000	8.20e-03
UCH proteinases	85	3.83e-04	-0.223000	2.15e-03
Constitutive Signaling by Overexpressed ERBB2	11	2.01e-01	-0.223000	3.26e-01
Somitogenesis	50	6.47e-03	-0.223000	2.32e-02
Unwinding of DNA	10	2.23e-01	-0.223000	3.52e-01
Removal of the Flap Intermediate	14	1.49e-01	-0.223000	2.64e-01
SUMOylation of ubiquitinylation proteins	39	1.63e-02	-0.222000	4.75e-02
RMTs methylate histone arginines	33	2.71e-02	-0.222000	7.14e-02
Ub-specific processing proteases	157	1.58e-06	-0.222000	1.97e-05
Defects in cobalamin (B12) metabolism	12	1.83e-01	-0.222000	3.05e-01
SHC1 events in ERBB4 signaling	12	1.83e-01	0.222000	3.05e-01
Cell junction organization	92	2.37e-04	0.222000	1.43e-03
RNA Polymerase III Abortive And Retractive Initiation	41	1.41e-02	-0.222000	4.23e-02
RNA Polymerase III Transcription	41	1.41e-02	-0.222000	4.23e-02
Inflammasomes	20	8.68e-02	-0.221000	1.77e-01
Erythropoietin activates RAS	13	1.68e-01	-0.221000	2.88e-01
RNA Polymerase III Transcription Initiation	36	2.20e-02	-0.221000	6.09e-02
Transcriptional Regulation by E2F6	33	2.87e-02	-0.220000	7.50e-02
Uptake and actions of bacterial toxins	24	6.21e-02	-0.220000	1.37e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	1.70e-01	-0.220000	2.91e-01
Golgi Associated Vesicle Biogenesis	54	5.26e-03	-0.220000	1.95e-02
Activation of GABAB receptors	31	3.49e-02	0.219000	8.62e-02
GABA B receptor activation	31	3.49e-02	0.219000	8.62e-02
TCF dependent signaling in response to WNT	161	1.67e-06	-0.219000	2.04e-05
Fatty acyl-CoA biosynthesis	31	3.51e-02	0.219000	8.65e-02
Signal transduction by L1	21	8.29e-02	0.219000	1.71e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	15	1.43e-01	-0.218000	2.56e-01
Retrograde transport at the Trans-Golgi-Network	49	8.18e-03	-0.218000	2.78e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	1.74e-01	-0.218000	2.94e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	3.92e-02	-0.218000	9.50e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	3.92e-02	-0.218000	9.50e-02
FOXO-mediated transcription	56	4.89e-03	-0.217000	1.82e-02
HCMV Infection	100	1.76e-04	-0.217000	1.11e-03
SHC1 events in EGFR signaling	10	2.35e-01	0.217000	3.66e-01
RAS processing	22	7.84e-02	-0.217000	1.64e-01
TCR signaling	100	1.87e-04	-0.216000	1.17e-03
MicroRNA (miRNA) biogenesis	25	6.15e-02	-0.216000	1.36e-01
PCP/CE pathway	87	4.97e-04	-0.216000	2.71e-03
Ephrin signaling	18	1.13e-01	0.216000	2.15e-01
PIWI-interacting RNA (piRNA) biogenesis	20	9.44e-02	-0.216000	1.88e-01
Negative regulation of MAPK pathway	41	1.68e-02	-0.216000	4.86e-02
MAPK6/MAPK4 signaling	84	6.35e-04	-0.216000	3.30e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs	72	1.58e-03	-0.215000	7.01e-03
Transcriptional Regulation by TP53	338	1.12e-11	-0.215000	2.68e-10
NOTCH1 Intracellular Domain Regulates Transcription	47	1.09e-02	-0.215000	3.48e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	49	9.37e-03	-0.215000	3.09e-02
The role of Nef in HIV-1 replication and disease pathogenesis	24	6.92e-02	-0.214000	1.49e-01
G1/S DNA Damage Checkpoints	62	3.62e-03	-0.214000	1.42e-02
Caspase-mediated cleavage of cytoskeletal proteins	12	2.01e-01	0.213000	3.26e-01
HS-GAG biosynthesis	22	8.37e-02	0.213000	1.72e-01
SARS-CoV Infections	373	1.86e-12	-0.213000	4.79e-11
Collagen biosynthesis and modifying enzymes	64	3.27e-03	0.213000	1.30e-02
B-WICH complex positively regulates rRNA expression	38	2.34e-02	-0.213000	6.37e-02
Activated NTRK2 signals through FRS2 and FRS3	11	2.22e-01	-0.212000	3.52e-01
Post-translational modification: synthesis of GPI-anchored proteins	58	5.20e-03	0.212000	1.93e-02
EPH-ephrin mediated repulsion of cells	44	1.50e-02	0.212000	4.45e-02
Protein-protein interactions at synapses	61	4.22e-03	0.212000	1.61e-02
Transport of the SLBP independent Mature mRNA	35	3.04e-02	-0.212000	7.79e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	1.11e-01	-0.211000	2.13e-01
Infectious disease	824	1.42e-24	-0.211000	5.78e-23
RHO GTPases Activate ROCKs	19	1.12e-01	0.211000	2.14e-01
Telomere Extension By Telomerase	21	9.51e-02	-0.210000	1.89e-01
SUMOylation of intracellular receptors	27	5.84e-02	-0.210000	1.31e-01
Listeria monocytogenes entry into host cells	17	1.33e-01	-0.210000	2.45e-01
Regulation of insulin secretion	61	4.63e-03	0.210000	1.74e-02
Advanced glycosylation endproduct receptor signaling	12	2.09e-01	0.210000	3.36e-01
ER-Phagosome pathway	79	1.38e-03	-0.208000	6.20e-03
Glucose metabolism	83	1.05e-03	-0.208000	5.07e-03
Activation of gene expression by SREBF (SREBP)	42	2.01e-02	-0.207000	5.72e-02
Mitotic Prophase	89	7.36e-04	-0.207000	3.76e-03
Biotin transport and metabolism	11	2.35e-01	-0.207000	3.66e-01
Nuclear Envelope (NE) Reassembly	68	3.23e-03	-0.207000	1.29e-02
RA biosynthesis pathway	15	1.66e-01	-0.207000	2.85e-01
Negative regulators of DDX58/IFIH1 signaling	34	3.76e-02	-0.206000	9.19e-02
ECM proteoglycans	66	3.84e-03	0.206000	1.49e-02
TP53 Regulates Transcription of Death Receptors and Ligands	11	2.41e-01	0.204000	3.72e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	23	9.04e-02	-0.204000	1.82e-01
Packaging Of Telomere Ends	13	2.04e-01	-0.203000	3.31e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	12	2.23e-01	0.203000	3.52e-01
Muscle contraction	165	6.84e-06	0.203000	6.95e-05
Antigen processing: Ubiquitination & Proteasome degradation	291	2.80e-09	-0.203000	5.26e-08
Platelet calcium homeostasis	23	9.24e-02	0.203000	1.85e-01
G-protein mediated events	50	1.32e-02	0.203000	3.98e-02
CRMPs in Sema3A signaling	15	1.74e-01	0.203000	2.95e-01
Heme biosynthesis	13	2.07e-01	-0.202000	3.34e-01
DNA strand elongation	30	5.56e-02	-0.202000	1.27e-01
Glutathione conjugation	27	6.99e-02	-0.202000	1.50e-01
Frs2-mediated activation	12	2.27e-01	-0.201000	3.57e-01
Cargo concentration in the ER	28	6.55e-02	-0.201000	1.43e-01
Defective B4GALT7 causes EDS, progeroid type	16	1.65e-01	0.200000	2.84e-01
Gap junction assembly	20	1.21e-01	0.200000	2.27e-01
Deubiquitination	228	2.08e-07	-0.200000	2.99e-06
Rab regulation of trafficking	115	2.19e-04	-0.200000	1.35e-03
Rap1 signalling	13	2.13e-01	0.199000	3.39e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	1.33e-01	-0.199000	2.44e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	1.33e-01	-0.199000	2.44e-01
Metabolism of fat-soluble vitamins	32	5.19e-02	0.199000	1.20e-01
GPER1 signaling	37	3.66e-02	0.199000	8.99e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation	33	4.84e-02	-0.199000	1.13e-01
Metabolism of Angiotensinogen to Angiotensins	13	2.15e-01	0.198000	3.43e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	6.16e-03	-0.198000	2.23e-02
Cleavage of the damaged purine	16	1.71e-01	-0.198000	2.91e-01
Depurination	16	1.71e-01	-0.198000	2.91e-01
Recognition and association of DNA glycosylase with site containing an affected purine	16	1.71e-01	-0.198000	2.91e-01
Positive epigenetic regulation of rRNA expression	53	1.28e-02	-0.198000	3.89e-02
Antigen processing-Cross presentation	92	1.09e-03	-0.197000	5.20e-03
PRC2 methylates histones and DNA	20	1.28e-01	-0.197000	2.37e-01
Sensory perception of taste	16	1.74e-01	0.196000	2.95e-01
eNOS activation	11	2.60e-01	-0.196000	3.92e-01
PLC beta mediated events	46	2.18e-02	0.196000	6.08e-02
RHO GTPases activate PAKs	21	1.22e-01	0.195000	2.28e-01
Fc epsilon receptor (FCERI) signaling	128	1.40e-04	-0.195000	9.38e-04
Transport of Mature mRNA Derived from an Intronless Transcript	42	2.96e-02	-0.194000	7.66e-02
Signaling by Erythropoietin	24	1.00e-01	-0.194000	1.98e-01
Sensory Perception	153	3.65e-05	0.194000	2.84e-04
Formation of paraxial mesoderm	62	8.45e-03	-0.193000	2.85e-02
RIPK1-mediated regulated necrosis	30	6.72e-02	-0.193000	1.45e-01
Regulation of necroptotic cell death	30	6.72e-02	-0.193000	1.45e-01
Metabolic disorders of biological oxidation enzymes	22	1.18e-01	-0.193000	2.23e-01
Synthesis of very long-chain fatty acyl-CoAs	19	1.46e-01	0.193000	2.60e-01
EPH-Ephrin signaling	83	2.59e-03	0.191000	1.07e-02
Lagging Strand Synthesis	20	1.38e-01	-0.191000	2.51e-01
PECAM1 interactions	11	2.72e-01	0.191000	4.08e-01
G1/S Transition	123	2.54e-04	-0.191000	1.52e-03
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	8.02e-02	-0.191000	1.68e-01
Nuclear Envelope Breakdown	53	1.63e-02	-0.191000	4.75e-02
CASP8 activity is inhibited	10	2.96e-01	0.191000	4.36e-01
Dimerization of procaspase-8	10	2.96e-01	0.191000	4.36e-01
Regulation by c-FLIP	10	2.96e-01	0.191000	4.36e-01
RAF activation	34	5.46e-02	-0.191000	1.25e-01
Transport of the SLBP Dependant Mature mRNA	36	4.82e-02	-0.190000	1.13e-01
Bile acid and bile salt metabolism	28	8.13e-02	-0.190000	1.69e-01
Signaling by NOTCH4	81	3.11e-03	-0.190000	1.25e-02
Removal of the Flap Intermediate from the C-strand	17	1.75e-01	-0.190000	2.96e-01
NGF-stimulated transcription	35	5.22e-02	0.190000	1.20e-01
Processive synthesis on the lagging strand	15	2.04e-01	-0.189000	3.31e-01
ER to Golgi Anterograde Transport	140	1.11e-04	-0.189000	7.67e-04
DDX58/IFIH1-mediated induction of interferon-alpha/beta	66	7.86e-03	-0.189000	2.73e-02
Signaling by FGFR1 in disease	32	6.43e-02	-0.189000	1.41e-01
Base Excision Repair	51	1.97e-02	-0.189000	5.62e-02
RNA Polymerase III Transcription Termination	23	1.17e-01	-0.189000	2.22e-01
Class I MHC mediated antigen processing & presentation	352	1.27e-09	-0.189000	2.44e-08
Synthesis of PIPs at the early endosome membrane	16	1.92e-01	-0.189000	3.15e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	6.16e-02	-0.188000	1.36e-01
RUNX3 regulates p14-ARF	10	3.04e-01	-0.188000	4.42e-01
Generation of second messenger molecules	18	1.68e-01	0.188000	2.88e-01
Processing of Capped Intronless Pre-mRNA	29	8.08e-02	-0.187000	1.68e-01
Disorders of transmembrane transporters	136	1.69e-04	-0.187000	1.08e-03
Nuclear Receptor transcription pathway	43	3.40e-02	-0.187000	8.44e-02
Transcriptional Regulation by VENTX	37	4.98e-02	-0.186000	1.16e-01
Cell surface interactions at the vascular wall	104	1.04e-03	0.186000	5.05e-03
Miscellaneous transport and binding events	20	1.50e-01	0.186000	2.65e-01
Integrin signaling	23	1.23e-01	0.186000	2.31e-01
Signaling by GPCR	404	1.70e-10	0.186000	3.65e-09
Germ layer formation at gastrulation	10	3.12e-01	-0.185000	4.49e-01
PI3K events in ERBB2 signaling	14	2.33e-01	0.184000	3.63e-01
FGFR1 mutant receptor activation	25	1.11e-01	-0.184000	2.13e-01
Resolution of Abasic Sites (AP sites)	38	5.04e-02	-0.183000	1.17e-01
FLT3 signaling in disease	27	9.95e-02	-0.183000	1.96e-01
Neddylation	233	1.53e-06	-0.183000	1.94e-05
KSRP (KHSRP) binds and destabilizes mRNA	17	1.92e-01	-0.183000	3.15e-01
SHC-mediated cascade:FGFR2	14	2.36e-01	0.183000	3.67e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	16	2.05e-01	0.183000	3.32e-01
Acyl chain remodelling of PS	15	2.20e-01	0.183000	3.50e-01
Aquaporin-mediated transport	36	5.79e-02	0.183000	1.30e-01
ISG15 antiviral mechanism	71	7.93e-03	-0.182000	2.74e-02
trans-Golgi Network Vesicle Budding	68	9.47e-03	-0.182000	3.10e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.94e-01	-0.182000	3.17e-01
Downregulation of ERBB2:ERBB3 signaling	13	2.57e-01	-0.181000	3.89e-01
Metabolism of proteins	1630	1.73e-33	-0.181000	2.11e-31
Mitotic Anaphase	209	7.06e-06	-0.180000	7.12e-05
Signaling by CSF1 (M-CSF) in myeloid cells	31	8.21e-02	-0.180000	1.70e-01
Regulation of MECP2 expression and activity	28	9.86e-02	-0.180000	1.96e-01
Aggrephagy	34	6.94e-02	-0.180000	1.49e-01
Signaling by Activin	14	2.44e-01	0.180000	3.75e-01
GPCR downstream signalling	363	4.35e-09	0.180000	7.95e-08
Glutamate Neurotransmitter Release Cycle	20	1.65e-01	0.179000	2.84e-01
Diseases of glycosylation	125	5.43e-04	0.179000	2.89e-03
Regulation of localization of FOXO transcription factors	11	3.05e-01	-0.179000	4.42e-01
Cellular hexose transport	14	2.48e-01	0.179000	3.78e-01
Signaling by WNT	240	2.09e-06	-0.178000	2.45e-05
Signaling by FGFR in disease	54	2.37e-02	-0.178000	6.44e-02
Metabolism	1742	3.78e-34	-0.178000	5.02e-32
Telomere Maintenance	70	1.02e-02	-0.178000	3.30e-02
RNA Polymerase III Chain Elongation	18	1.92e-01	-0.178000	3.15e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	1.41e-01	-0.178000	2.53e-01
CTLA4 inhibitory signaling	18	1.93e-01	-0.177000	3.15e-01
Activation of AMPK downstream of NMDARs	22	1.50e-01	0.177000	2.65e-01
Recognition of DNA damage by PCNA-containing replication complex	29	9.90e-02	-0.177000	1.96e-01
Negative epigenetic regulation of rRNA expression	56	2.20e-02	-0.177000	6.09e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	1.26e-01	-0.177000	2.35e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	4.50e-02	-0.177000	1.07e-01
Neuronal System	266	7.35e-07	0.177000	9.86e-06
RNA Polymerase I Promoter Escape	38	5.96e-02	-0.177000	1.33e-01
WNT5A-dependent internalization of FZD4	14	2.54e-01	-0.176000	3.85e-01
Glycogen metabolism	24	1.36e-01	-0.176000	2.48e-01
Semaphorin interactions	63	1.57e-02	0.176000	4.65e-02
AKT phosphorylates targets in the nucleus	10	3.35e-01	-0.176000	4.68e-01
Transport of vitamins, nucleosides, and related molecules	29	1.01e-01	0.176000	1.99e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	7.64e-02	0.176000	1.61e-01
DAG and IP3 signaling	38	6.16e-02	0.175000	1.36e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	3.14e-01	0.175000	4.51e-01
Mitotic Metaphase and Anaphase	210	1.26e-05	-0.175000	1.13e-04
GRB2 events in ERBB2 signaling	14	2.58e-01	0.175000	3.90e-01
Regulation of IFNA/IFNB signaling	12	2.95e-01	0.175000	4.36e-01
RHO GTPases activate KTN1	10	3.41e-01	-0.174000	4.74e-01
M Phase	336	4.84e-08	-0.174000	7.53e-07
Ovarian tumor domain proteases	36	7.17e-02	-0.174000	1.53e-01
Neurotransmitter receptors and postsynaptic signal transmission	144	3.42e-04	0.173000	1.95e-03
NS1 Mediated Effects on Host Pathways	40	5.91e-02	-0.172000	1.32e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	70	1.29e-02	-0.172000	3.90e-02
Adherens junctions interactions	48	3.95e-02	0.172000	9.54e-02
tRNA processing	109	1.98e-03	-0.172000	8.40e-03
SHC1 events in ERBB2 signaling	20	1.86e-01	0.171000	3.07e-01
Heparan sulfate/heparin (HS-GAG) metabolism	41	5.83e-02	0.171000	1.31e-01
Senescence-Associated Secretory Phenotype (SASP)	54	3.01e-02	-0.171000	7.77e-02
WNT ligand biogenesis and trafficking	15	2.53e-01	-0.171000	3.83e-01
The canonical retinoid cycle in rods (twilight vision)	12	3.06e-01	0.171000	4.44e-01
Activation of G protein gated Potassium channels	18	2.10e-01	0.171000	3.37e-01
G protein gated Potassium channels	18	2.10e-01	0.171000	3.37e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	2.10e-01	0.171000	3.37e-01
Unblocking of NMDA receptors, glutamate binding and activation	17	2.24e-01	0.170000	3.53e-01
Post NMDA receptor activation events	67	1.62e-02	0.170000	4.74e-02
Scavenging by Class A Receptors	16	2.39e-01	0.170000	3.71e-01
FCGR3A-mediated IL10 synthesis	37	7.46e-02	0.169000	1.58e-01
Plasma lipoprotein assembly	11	3.32e-01	0.169000	4.66e-01
Activation of NMDA receptors and postsynaptic events	78	9.91e-03	0.169000	3.22e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses	101	3.37e-03	-0.169000	1.33e-02
Chaperonin-mediated protein folding	75	1.15e-02	-0.169000	3.60e-02
Cell-Cell communication	121	1.35e-03	0.169000	6.12e-03
Hedgehog ‘on’ state	82	8.32e-03	-0.169000	2.81e-02
Inwardly rectifying K+ channels	23	1.62e-01	0.169000	2.81e-01
Leading Strand Synthesis	14	2.76e-01	-0.168000	4.12e-01
Polymerase switching	14	2.76e-01	-0.168000	4.12e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	2.60e-01	-0.168000	3.92e-01
Ca-dependent events	34	9.06e-02	0.168000	1.82e-01
Regulation of TP53 Expression and Degradation	36	8.19e-02	-0.168000	1.70e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	3.16e-01	-0.167000	4.52e-01
Tight junction interactions	17	2.33e-01	0.167000	3.63e-01
Transcriptional Regulation by NPAS4	31	1.07e-01	-0.167000	2.08e-01
Assembly of the ORC complex at the origin of replication	15	2.63e-01	-0.167000	3.95e-01
HCMV Early Events	77	1.13e-02	-0.167000	3.54e-02
Apoptotic cleavage of cellular proteins	35	8.73e-02	0.167000	1.77e-01
Signaling by ALK fusions and activated point mutants	53	3.60e-02	-0.167000	8.86e-02
Signaling by ALK in cancer	53	3.60e-02	-0.167000	8.86e-02
TNFR2 non-canonical NF-kB pathway	85	8.14e-03	-0.166000	2.78e-02
Nuclear Pore Complex (NPC) Disassembly	36	8.46e-02	-0.166000	1.73e-01
Interferon gamma signaling	72	1.50e-02	0.166000	4.45e-02
Cytochrome P450 - arranged by substrate type	33	9.93e-02	-0.166000	1.96e-01
ATF6 (ATF6-alpha) activates chaperones	12	3.20e-01	-0.166000	4.57e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	1.44e-01	-0.166000	2.57e-01
IL-6-type cytokine receptor ligand interactions	13	3.03e-01	0.165000	4.41e-01
RAB GEFs exchange GTP for GDP on RABs	84	8.98e-03	-0.165000	3.00e-02
RNA Polymerase I Transcription Initiation	47	5.06e-02	-0.165000	1.17e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	2.40e-01	-0.165000	3.71e-01
COPI-independent Golgi-to-ER retrograde traffic	45	5.66e-02	-0.164000	1.29e-01
Cell-cell junction organization	67	2.04e-02	0.164000	5.77e-02
Platelet sensitization by LDL	17	2.43e-01	-0.164000	3.74e-01
RNA Polymerase I Promoter Clearance	57	3.26e-02	-0.164000	8.14e-02
RNA Polymerase I Transcription	57	3.26e-02	-0.164000	8.14e-02
Aspirin ADME	15	2.74e-01	-0.163000	4.11e-01
G1/S-Specific Transcription	23	1.77e-01	-0.163000	2.97e-01
Gene expression (Transcription)	1352	2.93e-23	-0.163000	1.16e-21
Metabolism of nitric oxide: NOS3 activation and regulation	15	2.77e-01	-0.162000	4.13e-01
Phase I - Functionalization of compounds	67	2.20e-02	-0.162000	6.09e-02
Bacterial Infection Pathways	63	2.63e-02	-0.162000	6.98e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.61e-01	-0.162000	2.81e-01
Synthesis of PIPs at the plasma membrane	51	4.59e-02	-0.162000	1.08e-01
Regulation of TP53 Activity	149	6.76e-04	-0.161000	3.49e-03
Meiosis	50	4.84e-02	-0.161000	1.13e-01
RHOV GTPase cycle	34	1.04e-01	-0.161000	2.03e-01
TNFR1-induced proapoptotic signaling	24	1.72e-01	-0.161000	2.92e-01
Activation of HOX genes during differentiation	67	2.27e-02	-0.161000	6.24e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis	67	2.27e-02	-0.161000	6.24e-02
Transport to the Golgi and subsequent modification	165	3.69e-04	-0.161000	2.09e-03
Early SARS-CoV-2 Infection Events	32	1.15e-01	-0.161000	2.20e-01
Transcriptional regulation by RUNX1	165	4.09e-04	-0.160000	2.28e-03
Regulation of TP53 Degradation	35	1.03e-01	-0.159000	2.02e-01
Synthesis of PC	23	1.87e-01	-0.159000	3.09e-01
Anti-inflammatory response favouring Leishmania parasite infection	66	2.62e-02	0.158000	6.97e-02
Leishmania parasite growth and survival	66	2.62e-02	0.158000	6.97e-02
RHOH GTPase cycle	31	1.28e-01	-0.158000	2.38e-01
G beta:gamma signalling through BTK	12	3.47e-01	0.157000	4.78e-01
Separation of Sister Chromatids	166	5.07e-04	-0.157000	2.75e-03
Transcriptional regulation by RUNX2	113	4.09e-03	-0.156000	1.57e-02
ADORA2B mediated anti-inflammatory cytokines production	34	1.16e-01	0.156000	2.20e-01
ROS and RNS production in phagocytes	29	1.47e-01	-0.156000	2.61e-01
Protein folding	81	1.56e-02	-0.156000	4.60e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	1.07e-01	-0.155000	2.08e-01
G beta:gamma signalling through PLC beta	14	3.15e-01	0.155000	4.51e-01
Attachment and Entry 9694614	15	3.01e-01	0.154000	4.39e-01
Cyclin A/B1/B2 associated events during G2/M transition	21	2.22e-01	0.154000	3.51e-01
MET promotes cell motility	40	9.23e-02	0.154000	1.85e-01
Nuclear events stimulated by ALK signaling in cancer	17	2.72e-01	-0.154000	4.08e-01
Glucagon signaling in metabolic regulation	26	1.76e-01	0.153000	2.97e-01
DNA Repair	278	1.14e-05	-0.153000	1.06e-04
DNA methylation	11	3.80e-01	-0.153000	5.13e-01
RNA Polymerase I Promoter Opening	10	4.02e-01	-0.153000	5.35e-01
A tetrasaccharide linker sequence is required for GAG synthesis	20	2.37e-01	0.153000	3.68e-01
Telomere C-strand synthesis initiation	13	3.41e-01	-0.153000	4.74e-01
Dopamine Neurotransmitter Release Cycle	19	2.50e-01	0.152000	3.80e-01
Cytosolic sensors of pathogen-associated DNA	62	3.80e-02	-0.152000	9.24e-02
CaM pathway	32	1.36e-01	0.152000	2.48e-01
Calmodulin induced events	32	1.36e-01	0.152000	2.48e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	3.82e-01	-0.152000	5.14e-01
G alpha (i) signalling events	174	5.42e-04	0.152000	2.89e-03
NoRC negatively regulates rRNA expression	53	5.60e-02	-0.152000	1.28e-01
TP53 Regulates Transcription of Cell Cycle Genes	43	8.54e-02	-0.152000	1.74e-01
CD209 (DC-SIGN) signaling	20	2.41e-01	-0.152000	3.72e-01
Signaling by TGF-beta Receptor Complex	92	1.21e-02	-0.151000	3.74e-02
Signaling by Leptin	11	3.85e-01	-0.151000	5.16e-01
RUNX2 regulates osteoblast differentiation	21	2.30e-01	0.151000	3.61e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	2.12e-01	0.150000	3.38e-01
SUMOylation of immune response proteins	11	3.88e-01	-0.150000	5.20e-01
Sensory processing of sound by outer hair cells of the cochlea	38	1.09e-01	0.150000	2.10e-01
Diseases of carbohydrate metabolism	29	1.62e-01	-0.150000	2.81e-01
Transcriptional regulation by RUNX3	95	1.16e-02	-0.150000	3.63e-02
Lysosome Vesicle Biogenesis	31	1.49e-01	-0.150000	2.63e-01
Membrane Trafficking	565	1.38e-09	-0.150000	2.62e-08
LDL clearance	17	2.86e-01	-0.150000	4.24e-01
G alpha (s) signalling events	89	1.48e-02	0.150000	4.41e-02
RAF-independent MAPK1/3 activation	20	2.49e-01	0.149000	3.80e-01
EPHB-mediated forward signaling	39	1.09e-01	0.148000	2.10e-01
Binding and Uptake of Ligands by Scavenger Receptors	34	1.35e-01	0.148000	2.47e-01
Regulation of FZD by ubiquitination	16	3.05e-01	-0.148000	4.42e-01
RNA Polymerase II Transcription	1195	1.28e-17	-0.148000	3.74e-16
Transmission across Chemical Synapses	190	4.72e-04	0.147000	2.60e-03
Intra-Golgi and retrograde Golgi-to-ER traffic	183	6.01e-04	-0.147000	3.14e-03
Cellular Senescence	127	4.23e-03	-0.147000	1.61e-02
Impaired BRCA2 binding to PALB2	21	2.44e-01	0.147000	3.75e-01
Neurotransmitter release cycle	36	1.29e-01	0.146000	2.39e-01
Infection with Mycobacterium tuberculosis	27	1.88e-01	-0.146000	3.11e-01
Diseases associated with glycosylation precursor biosynthesis	15	3.28e-01	-0.146000	4.63e-01
Iron uptake and transport	52	6.93e-02	-0.146000	1.49e-01
Extension of Telomeres	49	7.80e-02	-0.146000	1.64e-01
Cell Cycle, Mitotic	466	8.01e-08	-0.146000	1.21e-06
Response of Mtb to phagocytosis	23	2.28e-01	-0.145000	3.58e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	29	1.76e-01	0.145000	2.97e-01
Fatty acid metabolism	142	2.86e-03	-0.145000	1.16e-02
Acyl chain remodelling of PG	11	4.06e-01	0.145000	5.37e-01
Mitotic G1 phase and G1/S transition	139	3.29e-03	-0.145000	1.30e-02
Surfactant metabolism	18	2.89e-01	0.145000	4.27e-01
Activation of BAD and translocation to mitochondria	14	3.51e-01	-0.144000	4.82e-01
Platelet degranulation	111	8.96e-03	0.144000	3.00e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	2.45e-01	-0.143000	3.76e-01
Lysine catabolism	11	4.11e-01	-0.143000	5.40e-01
PERK regulates gene expression	30	1.75e-01	-0.143000	2.96e-01
Ion homeostasis	48	8.79e-02	0.142000	1.78e-01
Signaling by FGFR4 in disease	11	4.14e-01	-0.142000	5.42e-01
Gluconeogenesis	29	1.85e-01	-0.142000	3.06e-01
G-protein activation	17	3.12e-01	0.142000	4.49e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	4.16e-01	-0.142000	5.43e-01
Hemostasis	481	1.14e-07	0.142000	1.68e-06
Synaptic adhesion-like molecules	17	3.13e-01	0.141000	4.51e-01
Initiation of Nuclear Envelope (NE) Reformation	19	2.87e-01	-0.141000	4.25e-01
Antiviral mechanism by IFN-stimulated genes	79	3.09e-02	-0.141000	7.88e-02
Depolymerization of the Nuclear Lamina	15	3.46e-01	-0.141000	4.78e-01
DARPP-32 events	23	2.43e-01	-0.141000	3.75e-01
Prostacyclin signalling through prostacyclin receptor	13	3.80e-01	0.140000	5.14e-01
Biological oxidations	137	4.73e-03	-0.140000	1.77e-02
Integration of energy metabolism	89	2.30e-02	0.140000	6.30e-02
Cardiac conduction	100	1.61e-02	0.139000	4.72e-02
Cell Cycle	573	1.37e-08	-0.139000	2.33e-07
Signaling by ERBB2 ECD mutants	16	3.35e-01	-0.139000	4.68e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	13	3.85e-01	0.139000	5.16e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	55	7.43e-02	-0.139000	1.58e-01
Transcriptional regulation of white adipocyte differentiation	81	3.15e-02	-0.138000	8.00e-02
Regulation of PTEN gene transcription	60	6.60e-02	-0.137000	1.44e-01
Assembly and cell surface presentation of NMDA receptors	33	1.73e-01	0.137000	2.94e-01
Spry regulation of FGF signaling	16	3.43e-01	-0.137000	4.76e-01
Polymerase switching on the C-strand of the telomere	26	2.29e-01	-0.136000	3.58e-01
Interleukin-12 family signaling	45	1.13e-01	-0.136000	2.17e-01
RND2 GTPase cycle	35	1.63e-01	-0.136000	2.82e-01
Interleukin-6 signaling	10	4.55e-01	-0.136000	5.79e-01
G alpha (z) signalling events	37	1.52e-01	0.136000	2.66e-01
Metabolism of steroid hormones	21	2.80e-01	0.136000	4.16e-01
Interleukin-1 signaling	108	1.49e-02	-0.136000	4.44e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	3.80e-01	0.136000	5.13e-01
Resolution of D-Loop Structures	30	1.99e-01	0.135000	3.25e-01
Intra-Golgi traffic	41	1.34e-01	-0.135000	2.45e-01
Nuclear signaling by ERBB4	29	2.09e-01	0.135000	3.36e-01
Processing of Intronless Pre-mRNAs	20	2.98e-01	-0.135000	4.37e-01
Regulation of TP53 Activity through Methylation	19	3.10e-01	-0.134000	4.48e-01
Regulation of CDH11 gene transcription	10	4.62e-01	0.134000	5.86e-01
Other interleukin signaling	20	2.99e-01	0.134000	4.38e-01
G alpha (12/13) signalling events	68	5.61e-02	0.134000	1.28e-01
RNA Polymerase I Transcription Termination	30	2.05e-01	-0.134000	3.31e-01
Vesicle-mediated transport	596	2.92e-08	-0.134000	4.65e-07
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	15	3.71e-01	-0.133000	5.06e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	15	3.71e-01	-0.133000	5.06e-01
Synthesis of PIPs at the Golgi membrane	15	3.72e-01	-0.133000	5.06e-01
Platelet activation, signaling and aggregation	223	6.29e-04	0.133000	3.27e-03
Metabolism of steroids	120	1.19e-02	-0.133000	3.70e-02
Disease	1460	6.87e-17	-0.132000	1.97e-15
FRS-mediated FGFR4 signaling	15	3.76e-01	0.132000	5.09e-01
Costimulation by the CD28 family	50	1.07e-01	-0.132000	2.08e-01
RHOB GTPase cycle	64	6.86e-02	0.132000	1.48e-01
Potential therapeutics for SARS	93	2.88e-02	-0.131000	7.51e-02
Signaling by EGFR in Cancer	21	2.99e-01	-0.131000	4.38e-01
Formation of tubulin folding intermediates by CCT/TriC	21	3.00e-01	-0.131000	4.39e-01
Maturation of nucleoprotein 9683610	11	4.55e-01	-0.130000	5.79e-01
Class I peroxisomal membrane protein import	20	3.14e-01	-0.130000	4.51e-01
Generic Transcription Pathway	1077	9.55e-13	-0.130000	2.49e-11
Response to elevated platelet cytosolic Ca2+	115	1.63e-02	0.130000	4.75e-02
Polo-like kinase mediated events	12	4.37e-01	-0.130000	5.59e-01
PIP3 activates AKT signaling	244	4.99e-04	-0.130000	2.71e-03
Serotonin Neurotransmitter Release Cycle	14	4.02e-01	0.129000	5.35e-01
Gap junction trafficking	31	2.14e-01	0.129000	3.41e-01
Plasma lipoprotein clearance	32	2.07e-01	-0.129000	3.34e-01
SHC-mediated cascade:FGFR3	12	4.42e-01	0.128000	5.64e-01
Beta-catenin independent WNT signaling	132	1.12e-02	-0.128000	3.54e-02
Signaling by FGFR2	61	8.41e-02	-0.128000	1.73e-01
Ion transport by P-type ATPases	44	1.43e-01	0.128000	2.56e-01
G2/M Transition	182	3.03e-03	-0.128000	1.22e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	24	2.81e-01	0.127000	4.17e-01
Cytosolic sulfonation of small molecules	18	3.51e-01	0.127000	4.82e-01
Mitotic G2-G2/M phases	184	3.03e-03	-0.127000	1.22e-02
Cardiogenesis	20	3.26e-01	0.127000	4.62e-01
Chondroitin sulfate/dermatan sulfate metabolism	41	1.60e-01	0.127000	2.80e-01
G2/M Checkpoints	122	1.59e-02	-0.126000	4.68e-02
PKA activation in glucagon signalling	16	3.81e-01	0.126000	5.14e-01
Kinesins	45	1.43e-01	0.126000	2.57e-01
COPI-mediated anterograde transport	91	3.79e-02	-0.126000	9.23e-02
ABC transporters in lipid homeostasis	13	4.32e-01	0.126000	5.56e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	84	4.65e-02	0.126000	1.09e-01
Signaling by ERBB2 TMD/JMD mutants	20	3.31e-01	0.126000	4.66e-01
Inactivation, recovery and regulation of the phototransduction cascade	19	3.44e-01	-0.125000	4.77e-01
Oxidative Stress Induced Senescence	69	7.22e-02	-0.125000	1.53e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	24	2.90e-01	0.125000	4.28e-01
Regulated Necrosis	52	1.20e-01	-0.125000	2.26e-01
Translation of Structural Proteins 9683701	29	2.46e-01	-0.124000	3.77e-01
GAB1 signalosome	13	4.40e-01	0.124000	5.63e-01
Cyclin D associated events in G1	45	1.52e-01	-0.124000	2.66e-01
G1 Phase	45	1.52e-01	-0.124000	2.66e-01
Glycosaminoglycan metabolism	103	3.05e-02	0.124000	7.79e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	18	3.65e-01	-0.123000	4.99e-01
Neurodegenerative Diseases	18	3.65e-01	-0.123000	4.99e-01
activated TAK1 mediates p38 MAPK activation	23	3.07e-01	-0.123000	4.45e-01
Fanconi Anemia Pathway	34	2.17e-01	-0.122000	3.45e-01
Programmed Cell Death	188	3.93e-03	-0.122000	1.51e-02
Regulation of IFNG signaling	13	4.47e-01	-0.122000	5.69e-01
Organelle biogenesis and maintenance	272	5.59e-04	-0.122000	2.95e-03
Platelet homeostasis	71	7.74e-02	0.121000	1.63e-01
Homologous DNA Pairing and Strand Exchange	39	1.92e-01	0.121000	3.15e-01
RIP-mediated NFkB activation via ZBP1	17	3.90e-01	-0.120000	5.22e-01
Metabolism of water-soluble vitamins and cofactors	110	3.02e-02	-0.120000	7.78e-02
Signaling by NOTCH	175	6.43e-03	-0.120000	2.31e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	4.08e-01	-0.119000	5.38e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	22	3.32e-01	0.119000	4.66e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	22	3.32e-01	0.119000	4.66e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	22	3.32e-01	0.119000	4.66e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	22	3.32e-01	0.119000	4.66e-01
PCNA-Dependent Long Patch Base Excision Repair	21	3.45e-01	-0.119000	4.77e-01
Caspase activation via Death Receptors in the presence of ligand	15	4.26e-01	0.119000	5.51e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	24	3.14e-01	-0.119000	4.51e-01
TGF-beta receptor signaling activates SMADs	46	1.65e-01	-0.118000	2.84e-01
p38MAPK events	13	4.60e-01	0.118000	5.84e-01
Class B/2 (Secretin family receptors)	52	1.41e-01	0.118000	2.54e-01
Gastrulation	85	6.01e-02	-0.118000	1.33e-01
Regulation of TP53 Activity through Phosphorylation	85	6.05e-02	-0.118000	1.34e-01
Telomere C-strand (Lagging Strand) Synthesis	34	2.35e-01	-0.118000	3.66e-01
Signaling by FGFR2 in disease	34	2.35e-01	-0.118000	3.66e-01
DNA Damage/Telomere Stress Induced Senescence	32	2.50e-01	-0.118000	3.80e-01
Apoptosis	161	1.02e-02	-0.117000	3.30e-02
G0 and Early G1	23	3.32e-01	-0.117000	4.66e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	76	7.92e-02	0.117000	1.66e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	15	4.35e-01	-0.116000	5.58e-01
Diseases of programmed cell death	48	1.64e-01	-0.116000	2.83e-01
Ras activation upon Ca2+ influx through NMDA receptor	16	4.21e-01	0.116000	5.48e-01
Regulation of CDH11 function	10	5.25e-01	0.116000	6.45e-01
RHOU GTPase cycle	39	2.11e-01	-0.116000	3.37e-01
MASTL Facilitates Mitotic Progression	10	5.26e-01	-0.116000	6.45e-01
Meiotic recombination	26	3.08e-01	-0.116000	4.46e-01
Translation of Structural Proteins 9694635	57	1.32e-01	-0.115000	2.43e-01
Extra-nuclear estrogen signaling	63	1.18e-01	0.114000	2.23e-01
NR1H2 and NR1H3-mediated signaling	40	2.13e-01	-0.114000	3.39e-01
Maturation of nucleoprotein 9694631	15	4.45e-01	-0.114000	5.68e-01
Gap junction trafficking and regulation	33	2.58e-01	0.114000	3.90e-01
Nuclear Events (kinase and transcription factor activation)	57	1.39e-01	0.113000	2.51e-01
Interconversion of nucleotide di- and triphosphates	27	3.09e-01	-0.113000	4.47e-01
Signaling by KIT in disease	19	3.95e-01	-0.113000	5.27e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	3.95e-01	-0.113000	5.27e-01
The phototransduction cascade	20	3.83e-01	-0.113000	5.15e-01
DCC mediated attractive signaling	13	4.86e-01	0.112000	6.09e-01
Thromboxane signalling through TP receptor	18	4.14e-01	0.111000	5.42e-01
Opioid Signalling	79	8.75e-02	0.111000	1.77e-01
Diseases of signal transduction by growth factor receptors and second messengers	393	1.61e-04	-0.111000	1.05e-03
Processive synthesis on the C-strand of the telomere	19	4.04e-01	-0.110000	5.36e-01
Azathioprine ADME	18	4.18e-01	-0.110000	5.44e-01
Interleukin-20 family signaling	14	4.76e-01	0.110000	6.01e-01
PI Metabolism	79	9.14e-02	-0.110000	1.83e-01
Signal amplification	25	3.44e-01	0.109000	4.77e-01
Formation of the beta-catenin:TCF transactivating complex	37	2.50e-01	-0.109000	3.80e-01
Phase II - Conjugation of compounds	66	1.25e-01	-0.109000	2.33e-01
Signaling by Nuclear Receptors	213	6.10e-03	-0.109000	2.21e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	5.51e-01	-0.109000	6.70e-01
Chromosome Maintenance	92	7.18e-02	-0.109000	1.53e-01
BBSome-mediated cargo-targeting to cilium	21	3.89e-01	-0.109000	5.20e-01
Golgi-to-ER retrograde transport	117	4.31e-02	-0.108000	1.03e-01
PI-3K cascade:FGFR4	13	5.00e-01	0.108000	6.21e-01
MAP kinase activation	63	1.40e-01	-0.107000	2.53e-01
Zinc transporters	10	5.57e-01	-0.107000	6.75e-01
FCERI mediated MAPK activation	33	2.88e-01	0.107000	4.26e-01
Metal ion SLC transporters	18	4.33e-01	-0.107000	5.56e-01
ERKs are inactivated	13	5.07e-01	0.106000	6.26e-01
Late SARS-CoV-2 Infection Events	65	1.40e-01	-0.106000	2.53e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	4.93e-01	0.106000	6.15e-01
ESR-mediated signaling	152	2.49e-02	-0.106000	6.70e-02
Notch-HLH transcription pathway	28	3.35e-01	-0.105000	4.68e-01
SARS-CoV-1 activates/modulates innate immune responses	39	2.56e-01	-0.105000	3.87e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	40	2.52e-01	-0.105000	3.82e-01
Signaling by FLT3 ITD and TKD mutants	15	4.84e-01	-0.104000	6.07e-01
PI-3K cascade:FGFR3	12	5.32e-01	-0.104000	6.50e-01
Signaling by FGFR2 IIIa TM	19	4.34e-01	-0.104000	5.57e-01
Downstream signaling of activated FGFR4	20	4.23e-01	0.104000	5.49e-01
STING mediated induction of host immune responses	15	4.89e-01	0.103000	6.12e-01
CD28 dependent PI3K/Akt signaling	20	4.25e-01	-0.103000	5.51e-01
RAB geranylgeranylation	54	1.91e-01	-0.103000	3.14e-01
Asparagine N-linked glycosylation	276	3.32e-03	-0.103000	1.31e-02
Activation of kainate receptors upon glutamate binding	22	4.04e-01	0.103000	5.36e-01
Presynaptic function of Kainate receptors	15	4.91e-01	0.103000	6.14e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	3.56e-01	-0.103000	4.89e-01
Defective Intrinsic Pathway for Apoptosis	21	4.17e-01	-0.102000	5.44e-01
Sensory processing of sound	52	2.02e-01	0.102000	3.28e-01
Activation of BH3-only proteins	27	3.58e-01	-0.102000	4.91e-01
Leishmania infection	147	3.27e-02	0.102000	8.14e-02
Parasitic Infection Pathways	147	3.27e-02	0.102000	8.14e-02
Adaptive Immune System	650	9.72e-06	-0.102000	9.42e-05
Nicotinamide salvaging	16	4.80e-01	-0.102000	6.05e-01
TRAF6 mediated IRF7 activation	15	4.95e-01	-0.102000	6.16e-01
Unfolded Protein Response (UPR)	89	9.70e-02	-0.102000	1.93e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	5.78e-01	-0.102000	6.91e-01
FOXO-mediated transcription of cell cycle genes	16	4.84e-01	-0.101000	6.07e-01
Sensory processing of sound by inner hair cells of the cochlea	47	2.31e-01	0.101000	3.62e-01
Metabolism of lipids	610	2.52e-05	-0.100000	2.02e-04
L1CAM interactions	102	8.13e-02	0.100000	1.69e-01
FCGR3A-mediated phagocytosis	60	1.81e-01	0.099800	3.03e-01
Leishmania phagocytosis	60	1.81e-01	0.099800	3.03e-01
Parasite infection	60	1.81e-01	0.099800	3.03e-01
Constitutive Signaling by Aberrant PI3K in Cancer	57	1.93e-01	0.099800	3.15e-01
E2F mediated regulation of DNA replication	21	4.29e-01	-0.099700	5.54e-01
Reproduction	65	1.66e-01	-0.099500	2.85e-01
RUNX2 regulates bone development	27	3.73e-01	0.099200	5.06e-01
Activated NOTCH1 Transmits Signal to the Nucleus	30	3.48e-01	0.099100	4.79e-01
The activation of arylsulfatases	10	5.88e-01	0.098900	7.00e-01
NPAS4 regulates expression of target genes	19	4.56e-01	-0.098800	5.79e-01
Post-translational protein modification	1190	1.29e-08	-0.098800	2.22e-07
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	32	3.34e-01	-0.098700	4.68e-01
PKA activation	17	4.82e-01	0.098400	6.06e-01
ATF4 activates genes in response to endoplasmic reticulum stress	25	3.95e-01	-0.098200	5.27e-01
Transport of connexons to the plasma membrane	14	5.25e-01	0.098100	6.45e-01
TRP channels	20	4.50e-01	0.097500	5.73e-01
Tie2 Signaling	16	5.00e-01	-0.097300	6.21e-01
VEGFR2 mediated vascular permeability	27	3.82e-01	-0.097200	5.14e-01
AKT phosphorylates targets in the cytosol	14	5.29e-01	-0.097100	6.48e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	71	1.59e-01	0.096800	2.77e-01
Hedgehog ‘off’ state	106	8.58e-02	-0.096700	1.75e-01
Cell Cycle Checkpoints	228	1.22e-02	-0.096500	3.75e-02
RHOG GTPase cycle	70	1.63e-01	-0.096500	2.82e-01
RAC1 GTPase cycle	174	2.90e-02	0.096100	7.54e-02
Interleukin-12 signaling	39	3.03e-01	-0.095400	4.41e-01
Caspase activation via extrinsic apoptotic signalling pathway	23	4.29e-01	0.095200	5.54e-01
Pre-NOTCH Transcription and Translation	40	2.98e-01	-0.095100	4.37e-01
RHOA GTPase cycle	141	5.18e-02	0.095000	1.20e-01
Interleukin-17 signaling	67	1.81e-01	-0.094600	3.03e-01
Amino acid transport across the plasma membrane	25	4.15e-01	0.094200	5.42e-01
Creation of C4 and C2 activators	10	6.06e-01	0.094100	7.16e-01
Pre-NOTCH Expression and Processing	56	2.26e-01	-0.093600	3.55e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	37	3.24e-01	0.093600	4.61e-01
Diseases of DNA Double-Strand Break Repair	37	3.24e-01	0.093600	4.61e-01
Signaling by RAF1 mutants	37	3.25e-01	0.093600	4.61e-01
Carboxyterminal post-translational modifications of tubulin	32	3.61e-01	0.093300	4.94e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	31	3.76e-01	-0.092000	5.09e-01
Regulation of NF-kappa B signaling	18	5.01e-01	-0.091700	6.21e-01
Keratan sulfate degradation	13	5.68e-01	-0.091600	6.83e-01
PKA-mediated phosphorylation of CREB	19	4.90e-01	0.091500	6.13e-01
Netrin-1 signaling	41	3.12e-01	0.091400	4.49e-01
Regulation of TP53 Activity through Association with Co-factors	11	6.00e-01	-0.091300	7.11e-01
ADP signalling through P2Y purinoceptor 1	19	4.93e-01	0.090800	6.15e-01
Glucagon-type ligand receptors	18	5.05e-01	0.090700	6.25e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	10	6.20e-01	-0.090700	7.27e-01
Sphingolipid de novo biosynthesis	38	3.38e-01	0.089900	4.71e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	5.76e-01	-0.089600	6.91e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	3.22e-01	-0.089500	4.58e-01
IRS-mediated signalling	37	3.50e-01	-0.088800	4.81e-01
IRE1alpha activates chaperones	50	2.78e-01	-0.088700	4.14e-01
DAP12 signaling	26	4.35e-01	0.088500	5.58e-01
FRS-mediated FGFR1 signaling	15	5.54e-01	0.088400	6.72e-01
Intracellular signaling by second messengers	281	1.11e-02	-0.088200	3.53e-02
RND1 GTPase cycle	36	3.61e-01	-0.088000	4.94e-01
O-linked glycosylation of mucins	41	3.30e-01	0.087900	4.66e-01
Interleukin-1 family signaling	136	8.05e-02	-0.086900	1.68e-01
Interleukin-4 and Interleukin-13 signaling	85	1.66e-01	0.086900	2.85e-01
NOD1/2 Signaling Pathway	36	3.67e-01	-0.086900	5.01e-01
Cargo trafficking to the periciliary membrane	45	3.18e-01	-0.086000	4.54e-01
SLC-mediated transmembrane transport	163	5.86e-02	0.085900	1.31e-01
PI3K Cascade	33	4.01e-01	-0.084600	5.33e-01
Killing mechanisms	10	6.44e-01	-0.084400	7.44e-01
WNT5:FZD7-mediated leishmania damping	10	6.44e-01	-0.084400	7.44e-01
XBP1(S) activates chaperone genes	48	3.16e-01	-0.083700	4.52e-01
GABA synthesis, release, reuptake and degradation	11	6.31e-01	0.083600	7.36e-01
Stimuli-sensing channels	76	2.11e-01	0.083000	3.37e-01
HDR through Single Strand Annealing (SSA)	33	4.09e-01	0.083000	5.38e-01
Gastrin-CREB signalling pathway via PKC and MAPK	16	5.66e-01	0.082900	6.82e-01
Syndecan interactions	26	4.68e-01	0.082300	5.92e-01
GPVI-mediated activation cascade	31	4.29e-01	-0.082100	5.54e-01
Glutamate and glutamine metabolism	11	6.39e-01	-0.081800	7.41e-01
FCERI mediated Ca+2 mobilization	31	4.31e-01	0.081700	5.56e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	5.38e-01	0.081600	6.56e-01
CD28 co-stimulation	31	4.32e-01	-0.081600	5.56e-01
Processing of DNA double-strand break ends	60	2.77e-01	-0.081100	4.13e-01
Regulation of PLK1 Activity at G2/M Transition	85	1.98e-01	-0.080800	3.23e-01
NRAGE signals death through JNK	56	2.96e-01	0.080800	4.36e-01
Cargo recognition for clathrin-mediated endocytosis	89	1.90e-01	-0.080400	3.13e-01
Role of phospholipids in phagocytosis	24	4.98e-01	0.080000	6.19e-01
RHO GTPases Activate WASPs and WAVEs	36	4.08e-01	0.079800	5.38e-01
Phospholipid metabolism	181	6.63e-02	-0.079200	1.44e-01
Trafficking of GluR2-containing AMPA receptors	14	6.11e-01	-0.078400	7.20e-01
Mucopolysaccharidoses	11	6.53e-01	0.078300	7.52e-01
Activation of the pre-replicative complex	28	4.74e-01	-0.078200	5.99e-01
Visual phototransduction	59	3.00e-01	0.078100	4.38e-01
Acyl chain remodelling of PI	10	6.70e-01	0.077900	7.69e-01
Post-chaperonin tubulin folding pathway	18	5.68e-01	0.077700	6.84e-01
TRAF6 mediated NF-kB activation	23	5.26e-01	-0.076500	6.45e-01
Signaling by FLT3 fusion proteins	19	5.64e-01	-0.076400	6.81e-01
Regulation of Expression and Function of Type II Classical Cadherins	29	4.79e-01	0.076000	6.03e-01
Regulation of Homotypic Cell-Cell Adhesion	29	4.79e-01	0.076000	6.03e-01
Incretin synthesis, secretion, and inactivation	13	6.35e-01	0.075900	7.39e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	13	6.35e-01	0.075900	7.39e-01
Presynaptic phase of homologous DNA pairing and strand exchange	36	4.32e-01	0.075800	5.56e-01
Plasma lipoprotein assembly, remodeling, and clearance	56	3.27e-01	-0.075800	4.63e-01
Axon guidance	489	4.28e-03	-0.075700	1.62e-02
Constitutive Signaling by EGFRvIII	15	6.14e-01	-0.075300	7.21e-01
Signaling by EGFRvIII in Cancer	15	6.14e-01	-0.075300	7.21e-01
Mitotic Spindle Checkpoint	96	2.05e-01	-0.074900	3.31e-01
Ca2+ pathway	53	3.49e-01	0.074400	4.81e-01
Metabolism of vitamins and cofactors	158	1.07e-01	-0.074300	2.08e-01
Interleukin receptor SHC signaling	20	5.69e-01	0.073600	6.84e-01
Cytochrome c-mediated apoptotic response	13	6.51e-01	0.072500	7.50e-01
DAP12 interactions	32	4.79e-01	0.072300	6.03e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	6.28e-01	0.072300	7.33e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	6.28e-01	0.072300	7.33e-01
DNA Double-Strand Break Repair	128	1.59e-01	-0.072200	2.77e-01
Signalling to RAS	20	5.77e-01	0.072100	6.91e-01
RUNX3 regulates NOTCH signaling	14	6.44e-01	-0.071400	7.44e-01
CDC42 GTPase cycle	145	1.38e-01	0.071400	2.51e-01
Signaling by NOTCH1	72	3.00e-01	-0.070600	4.39e-01
Death Receptor Signaling	146	1.42e-01	-0.070600	2.55e-01
Insulin receptor recycling	24	5.54e-01	-0.069800	6.72e-01
Ion channel transport	137	1.62e-01	0.069200	2.82e-01
Nervous system development	509	7.92e-03	-0.069000	2.74e-02
CD28 dependent Vav1 pathway	10	7.06e-01	-0.068900	7.97e-01
Downregulation of ERBB2 signaling	27	5.37e-01	-0.068700	6.56e-01
Diseases of DNA repair	46	4.23e-01	0.068200	5.50e-01
RHOD GTPase cycle	49	4.16e-01	-0.067200	5.43e-01
MET activates RAS signaling	11	7.00e-01	0.067000	7.94e-01
Interleukin-35 Signalling	10	7.15e-01	-0.066700	8.01e-01
Signaling by Hedgehog	140	1.80e-01	-0.065700	3.02e-01
Toll Like Receptor 9 (TLR9) Cascade	105	2.46e-01	-0.065500	3.77e-01
Factors involved in megakaryocyte development and platelet production	115	2.27e-01	0.065300	3.57e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	7.21e-01	0.065200	8.04e-01
MyD88-independent TLR4 cascade	107	2.47e-01	-0.064900	3.77e-01
TRIF(TICAM1)-mediated TLR4 signaling	107	2.47e-01	-0.064900	3.77e-01
Signaling by FGFR	71	3.45e-01	-0.064800	4.77e-01
Centrosome maturation	79	3.23e-01	-0.064400	4.60e-01
Recruitment of mitotic centrosome proteins and complexes	79	3.23e-01	-0.064400	4.60e-01
Regulated proteolysis of p75NTR	11	7.13e-01	-0.064000	8.00e-01
Mitotic Prometaphase	180	1.43e-01	-0.063400	2.56e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	4.10e-01	-0.063100	5.38e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	4.10e-01	-0.063100	5.38e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	4.10e-01	-0.063100	5.38e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	4.10e-01	-0.063100	5.38e-01
Signaling by NOTCH1 in Cancer	57	4.10e-01	-0.063100	5.38e-01
MECP2 regulates neuronal receptors and channels	14	6.83e-01	0.063100	7.78e-01
FGFR2 mutant receptor activation	24	5.93e-01	-0.063100	7.04e-01
Assembly of active LPL and LIPC lipase complexes	12	7.06e-01	-0.062800	7.97e-01
Negative regulation of FGFR1 signaling	25	5.88e-01	0.062700	7.00e-01
Growth hormone receptor signaling	19	6.38e-01	-0.062300	7.41e-01
Synthesis of substrates in N-glycan biosythesis	57	4.17e-01	0.062100	5.44e-01
Toll Like Receptor 3 (TLR3) Cascade	103	2.77e-01	-0.062000	4.13e-01
Downstream signaling of activated FGFR1	21	6.24e-01	0.061800	7.32e-01
EGFR downregulation	25	5.93e-01	-0.061800	7.04e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	83	3.32e-01	0.061600	4.66e-01
CS/DS degradation	10	7.37e-01	0.061400	8.16e-01
VEGFR2 mediated cell proliferation	19	6.46e-01	0.061000	7.45e-01
TP53 Regulates Transcription of Cell Death Genes	40	5.06e-01	0.060800	6.25e-01
Signaling by ERBB2 in Cancer	24	6.07e-01	0.060700	7.16e-01
Lewis blood group biosynthesis	10	7.40e-01	-0.060600	8.18e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	7.05e-01	0.060600	7.97e-01
Keratan sulfate biosynthesis	26	5.94e-01	-0.060400	7.05e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	6.96e-01	0.060400	7.91e-01
Triglyceride metabolism	24	6.09e-01	0.060300	7.18e-01
Neutrophil degranulation	406	4.03e-02	-0.059500	9.69e-02
Transcriptional Regulation by MECP2	48	4.82e-01	-0.058600	6.06e-01
Biosynthesis of specialized proresolving mediators (SPMs)	14	7.07e-01	0.058000	7.97e-01
Insulin processing	20	6.55e-01	-0.057700	7.53e-01
PI-3K cascade:FGFR1	13	7.19e-01	0.057600	8.04e-01
Signaling by ERBB2 KD Mutants	23	6.34e-01	0.057400	7.38e-01
Negative regulation of FGFR4 signaling	24	6.27e-01	0.057400	7.33e-01
Apoptotic execution phase	43	5.19e-01	0.056900	6.40e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	100	3.27e-01	-0.056800	4.62e-01
Mismatch Repair	14	7.13e-01	-0.056700	8.00e-01
TAK1-dependent IKK and NF-kappa-B activation	43	5.21e-01	-0.056500	6.43e-01
Clathrin-mediated endocytosis	128	2.76e-01	-0.055800	4.12e-01
Negative regulation of FGFR3 signaling	23	6.44e-01	-0.055600	7.44e-01
ALK mutants bind TKIs	11	7.50e-01	-0.055600	8.24e-01
Signaling by Insulin receptor	65	4.40e-01	-0.055400	5.62e-01
Signaling by FGFR3 in disease	16	7.01e-01	-0.055400	7.94e-01
Free fatty acids regulate insulin secretion	10	7.62e-01	-0.055300	8.35e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	102	3.36e-01	-0.055200	4.68e-01
Fcgamma receptor (FCGR) dependent phagocytosis	85	3.83e-01	0.054700	5.15e-01
Signaling by FGFR3	33	5.87e-01	-0.054700	7.00e-01
Sialic acid metabolism	27	6.25e-01	0.054400	7.32e-01
MyD88 dependent cascade initiated on endosome	101	3.45e-01	-0.054400	4.77e-01
Pre-NOTCH Processing in Golgi	18	6.89e-01	0.054400	7.85e-01
Signaling by high-kinase activity BRAF mutants	32	6.00e-01	0.053600	7.11e-01
Innate Immune System	841	9.19e-03	-0.053200	3.06e-02
Activation of SMO	16	7.13e-01	-0.053200	8.00e-01
MyD88 cascade initiated on plasma membrane	94	3.73e-01	-0.053200	5.06e-01
Toll Like Receptor 10 (TLR10) Cascade	94	3.73e-01	-0.053200	5.06e-01
Toll Like Receptor 5 (TLR5) Cascade	94	3.73e-01	-0.053200	5.06e-01
Oncogene Induced Senescence	32	6.04e-01	-0.053000	7.14e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	6.99e-01	0.052700	7.92e-01
RAC2 GTPase cycle	84	4.04e-01	-0.052700	5.36e-01
Role of LAT2/NTAL/LAB on calcium mobilization	17	7.07e-01	-0.052700	7.97e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	5.60e-01	0.052700	6.76e-01
Signaling by RAS mutants	41	5.60e-01	0.052700	6.76e-01
Signaling by moderate kinase activity BRAF mutants	41	5.60e-01	0.052700	6.76e-01
Signaling downstream of RAS mutants	41	5.60e-01	0.052700	6.76e-01
G beta:gamma signalling through CDC42	14	7.37e-01	0.051800	8.17e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	13	7.48e-01	0.051400	8.24e-01
Repression of WNT target genes	14	7.40e-01	-0.051200	8.18e-01
Interferon alpha/beta signaling	57	5.05e-01	0.051100	6.25e-01
TICAM1-dependent activation of IRF3/IRF7	12	7.64e-01	-0.050100	8.35e-01
Signaling by NTRK3 (TRKC)	16	7.30e-01	0.049800	8.11e-01
Diseases associated with glycosaminoglycan metabolism	37	6.02e-01	0.049600	7.12e-01
Signaling by ERBB2	47	5.60e-01	-0.049200	6.76e-01
Signaling by Hippo	19	7.12e-01	-0.048900	8.00e-01
Negative regulation of the PI3K/AKT network	90	4.24e-01	0.048800	5.50e-01
MHC class II antigen presentation	95	4.12e-01	-0.048700	5.40e-01
Intrinsic Pathway for Apoptosis	51	5.48e-01	-0.048700	6.66e-01
Glycerophospholipid biosynthesis	103	3.95e-01	-0.048600	5.27e-01
Maturation of spike protein 9694548	37	6.11e-01	-0.048300	7.20e-01
MET activates RAP1 and RAC1	11	7.82e-01	-0.048200	8.50e-01
FRS-mediated FGFR3 signaling	14	7.55e-01	-0.048200	8.28e-01
FCGR activation	13	7.64e-01	0.048200	8.35e-01
Nucleotide biosynthesis	12	7.74e-01	0.047900	8.43e-01
Regulation of TLR by endogenous ligand	15	7.48e-01	-0.047900	8.24e-01
SLC transporter disorders	67	5.01e-01	-0.047500	6.21e-01
Diseases of metabolism	204	2.43e-01	0.047500	3.74e-01
Diseases associated with the TLR signaling cascade	27	6.76e-01	-0.046400	7.73e-01
Diseases of Immune System	27	6.76e-01	-0.046400	7.73e-01
COPI-dependent Golgi-to-ER retrograde traffic	84	4.62e-01	-0.046400	5.86e-01
Plasma lipoprotein remodeling	20	7.20e-01	0.046300	8.04e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	7.64e-01	-0.046300	8.35e-01
Apoptotic factor-mediated response	20	7.22e-01	0.045900	8.05e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	21	7.16e-01	0.045900	8.01e-01
Developmental Biology	795	2.92e-02	-0.045800	7.58e-02
Impaired BRCA2 binding to RAD51	31	6.65e-01	0.045000	7.63e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	25	6.98e-01	0.044800	7.92e-01
Trafficking of AMPA receptors	25	6.98e-01	0.044800	7.92e-01
Regulation of beta-cell development	21	7.25e-01	-0.044400	8.07e-01
RHOJ GTPase cycle	52	5.82e-01	-0.044100	6.95e-01
Deposition of new CENPA-containing nucleosomes at the centromere	30	6.77e-01	0.044000	7.73e-01
Nucleosome assembly	30	6.77e-01	0.044000	7.73e-01
Signaling by Receptor Tyrosine Kinases	470	1.04e-01	0.043900	2.04e-01
RHO GTPases activate IQGAPs	24	7.10e-01	0.043800	7.99e-01
Formation of annular gap junctions	11	8.01e-01	0.043800	8.65e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	64	5.45e-01	-0.043700	6.65e-01
Insulin receptor signalling cascade	42	6.26e-01	-0.043400	7.33e-01
Peptide hormone metabolism	54	5.85e-01	0.042900	6.99e-01
IRS-related events triggered by IGF1R	40	6.44e-01	-0.042200	7.44e-01
Cell recruitment (pro-inflammatory response)	24	7.21e-01	0.042100	8.04e-01
Purinergic signaling in leishmaniasis infection	24	7.21e-01	0.042100	8.04e-01
AURKA Activation by TPX2	69	5.47e-01	-0.042000	6.66e-01
Signaling by TGFB family members	116	4.37e-01	-0.041800	5.59e-01
Signaling by ERBB4	51	6.07e-01	0.041600	7.17e-01
Acyl chain remodelling of PE	20	7.48e-01	-0.041400	8.24e-01
Metabolism of carbohydrates	251	2.60e-01	-0.041300	3.92e-01
N-Glycan antennae elongation	13	7.99e-01	-0.040900	8.64e-01
Immune System	1591	7.29e-03	-0.040900	2.56e-02
Transport of bile salts and organic acids, metal ions and amine compounds	47	6.38e-01	-0.039600	7.41e-01
RAC3 GTPase cycle	86	5.27e-01	0.039500	6.45e-01
Loss of Nlp from mitotic centrosomes	67	5.78e-01	-0.039400	6.91e-01
Loss of proteins required for interphase microtubule organization from the centrosome	67	5.78e-01	-0.039400	6.91e-01
Gap junction degradation	12	8.17e-01	0.038600	8.76e-01
Toll-like Receptor Cascades	156	4.07e-01	-0.038600	5.38e-01
Acyl chain remodelling of PC	19	7.72e-01	0.038400	8.42e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	17	7.85e-01	0.038200	8.53e-01
Signaling by FGFR1	40	6.76e-01	0.038200	7.73e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	42	6.74e-01	-0.037600	7.72e-01
Glycogen breakdown (glycogenolysis)	14	8.08e-01	-0.037500	8.69e-01
Myogenesis	26	7.44e-01	-0.037100	8.21e-01
Inositol phosphate metabolism	42	6.78e-01	0.037000	7.73e-01
Metabolism of nucleotides	85	5.56e-01	-0.037000	6.74e-01
Condensation of Prophase Chromosomes	20	7.77e-01	-0.036600	8.45e-01
RND3 GTPase cycle	36	7.11e-01	-0.035700	7.99e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	108	5.26e-01	-0.035300	6.45e-01
Toll Like Receptor 2 (TLR2) Cascade	108	5.26e-01	-0.035300	6.45e-01
Toll Like Receptor TLR1:TLR2 Cascade	108	5.26e-01	-0.035300	6.45e-01
Toll Like Receptor TLR6:TLR2 Cascade	108	5.26e-01	-0.035300	6.45e-01
Recruitment of NuMA to mitotic centrosomes	87	5.77e-01	-0.034600	6.91e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	17	8.08e-01	-0.034100	8.69e-01
Toll Like Receptor 4 (TLR4) Cascade	136	4.95e-01	-0.033900	6.16e-01
Pentose phosphate pathway	13	8.32e-01	0.033900	8.90e-01
Sphingolipid metabolism	74	6.15e-01	0.033800	7.22e-01
Anchoring of the basal body to the plasma membrane	94	5.73e-01	0.033600	6.89e-01
Amyloid fiber formation	43	7.07e-01	0.033100	7.97e-01
MyD88 deficiency (TLR2/4)	14	8.34e-01	-0.032300	8.91e-01
RHO GTPases activate PKNs	37	7.34e-01	0.032200	8.15e-01
Paracetamol ADME	19	8.08e-01	-0.032200	8.69e-01
MAP2K and MAPK activation	36	7.41e-01	0.031900	8.18e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	8.07e-01	-0.031600	8.69e-01
Pyroptosis	22	8.00e-01	-0.031300	8.64e-01
Regulation of innate immune responses to cytosolic DNA	14	8.40e-01	-0.031200	8.96e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	7.65e-01	-0.031000	8.36e-01
Downstream signaling of activated FGFR3	19	8.16e-01	-0.030800	8.76e-01
tRNA modification in the nucleus and cytosol	43	7.31e-01	-0.030300	8.11e-01
TRAF3-dependent IRF activation pathway	13	8.52e-01	0.029900	9.05e-01
Cilium Assembly	185	4.87e-01	-0.029700	6.10e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	8.60e-01	0.029500	9.11e-01
G-protein beta:gamma signalling	26	7.95e-01	-0.029400	8.61e-01
HDR through Homologous Recombination (HRR)	62	6.94e-01	0.028900	7.89e-01
Intraflagellar transport	49	7.30e-01	-0.028500	8.11e-01
Signal regulatory protein family interactions	11	8.70e-01	0.028400	9.20e-01
Nucleotide salvage	22	8.21e-01	0.027900	8.79e-01
Recycling pathway of L1	40	7.60e-01	0.027900	8.33e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	8.65e-01	-0.027200	9.17e-01
Transcriptional regulation of pluripotent stem cells	17	8.49e-01	0.026700	9.02e-01
Arachidonic acid metabolism	37	7.79e-01	0.026600	8.48e-01
Keratan sulfate/keratin metabolism	32	7.96e-01	-0.026500	8.61e-01
Interleukin-2 family signaling	33	7.94e-01	0.026300	8.61e-01
Resolution of Sister Chromatid Cohesion	104	6.49e-01	-0.025900	7.48e-01
G beta:gamma signalling through PI3Kgamma	19	8.46e-01	0.025800	9.01e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	8.83e-01	0.025600	9.28e-01
Nephrin family interactions	19	8.47e-01	0.025500	9.01e-01
Glycosphingolipid metabolism	36	7.91e-01	-0.025500	8.59e-01
VxPx cargo-targeting to cilium	17	8.56e-01	-0.025500	9.08e-01
Signaling by FGFR4	34	8.00e-01	0.025100	8.64e-01
Signaling by NTRKs	125	6.33e-01	0.024700	7.38e-01
Synthesis of PA	30	8.16e-01	0.024600	8.76e-01
Signal Transduction	2029	7.82e-02	0.024100	1.64e-01
Signaling by BRAF and RAF1 fusions	60	7.50e-01	0.023800	8.24e-01
Signaling by NTRK1 (TRKA)	108	6.74e-01	0.023400	7.72e-01
RET signaling	32	8.19e-01	-0.023400	8.77e-01
Regulation of actin dynamics for phagocytic cup formation	62	7.53e-01	0.023200	8.26e-01
Regulation of RUNX1 Expression and Activity	18	8.71e-01	0.022100	9.20e-01
Homology Directed Repair	98	7.08e-01	-0.021900	7.98e-01
FRS-mediated FGFR2 signaling	16	8.81e-01	0.021600	9.27e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	9.00e-01	0.021000	9.41e-01
Synthesis of PE	12	9.00e-01	0.020900	9.41e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	92	7.30e-01	-0.020800	8.11e-01
Downstream signaling of activated FGFR2	21	8.69e-01	0.020800	9.19e-01
Activation of ATR in response to replication stress	31	8.43e-01	0.020500	8.98e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	11	9.07e-01	-0.020400	9.46e-01
Interferon Signaling	164	6.55e-01	0.020200	7.53e-01
Synthesis, secretion, and deacylation of Ghrelin	11	9.12e-01	0.019300	9.50e-01
IGF1R signaling cascade	41	8.35e-01	-0.018800	8.91e-01
RHOC GTPase cycle	69	7.94e-01	0.018100	8.61e-01
Reduction of cytosolic Ca++ levels	10	9.22e-01	0.017900	9.58e-01
RHO GTPases Activate Formins	118	7.39e-01	0.017800	8.18e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	9.21e-01	0.017400	9.58e-01
Antimicrobial peptides	20	8.93e-01	0.017300	9.37e-01
Regulation of CDH11 Expression and Function	27	8.79e-01	0.016900	9.26e-01
PI-3K cascade:FGFR2	14	9.15e-01	-0.016400	9.53e-01
Pregnenolone biosynthesis	10	9.28e-01	-0.016400	9.61e-01
Trafficking and processing of endosomal TLR	12	9.22e-01	-0.016300	9.58e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	28	8.81e-01	0.016300	9.27e-01
MAPK family signaling cascades	274	6.46e-01	-0.016200	7.45e-01
Signaling by Interleukins	375	5.92e-01	-0.016100	7.04e-01
Drug ADME	59	8.33e-01	0.015900	8.90e-01
Signaling by NTRK2 (TRKB)	23	8.97e-01	0.015600	9.39e-01
Interleukin-15 signaling	13	9.25e-01	-0.015000	9.60e-01
MET receptor recycling	10	9.35e-01	-0.015000	9.63e-01
RHOF GTPase cycle	38	8.74e-01	0.014900	9.21e-01
Signaling by SCF-KIT	40	8.72e-01	-0.014700	9.20e-01
Pyrimidine salvage	10	9.39e-01	-0.013900	9.67e-01
Activation of the AP-1 family of transcription factors	10	9.40e-01	0.013800	9.67e-01
Signaling by NODAL	15	9.27e-01	0.013800	9.60e-01
PI3K/AKT Signaling in Cancer	84	8.30e-01	0.013500	8.89e-01
Signaling by NOTCH2	29	9.03e-01	0.013100	9.43e-01
G2/M DNA damage checkpoint	56	8.67e-01	-0.013000	9.17e-01
Signaling by MET	75	8.50e-01	-0.012700	9.03e-01
Nicotinate metabolism	28	9.10e-01	-0.012400	9.49e-01
Transcriptional regulation of granulopoiesis	34	9.01e-01	-0.012400	9.41e-01
Sema3A PAK dependent Axon repulsion	16	9.33e-01	-0.012100	9.63e-01
Signaling by NOTCH3	44	8.91e-01	-0.011900	9.35e-01
ERK/MAPK targets	22	9.23e-01	0.011900	9.59e-01
Interleukin-7 signaling	19	9.34e-01	-0.011000	9.63e-01
Blood group systems biosynthesis	13	9.45e-01	-0.011000	9.71e-01
Negative regulation of FGFR2 signaling	25	9.29e-01	-0.010300	9.61e-01
VEGFA-VEGFR2 Pathway	95	8.71e-01	0.009690	9.20e-01
Triglyceride catabolism	16	9.47e-01	-0.009600	9.72e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	9.44e-01	0.009110	9.70e-01
Aflatoxin activation and detoxification	11	9.59e-01	0.008980	9.79e-01
Cell death signalling via NRAGE, NRIF and NADE	73	8.95e-01	0.008950	9.38e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	12	9.59e-01	0.008540	9.79e-01
Purine catabolism	15	9.57e-01	-0.008120	9.79e-01
Transport of small molecules	544	7.50e-01	0.008010	8.24e-01
Nucleotide catabolism	27	9.48e-01	0.007300	9.72e-01
Cytokine Signaling in Immune system	576	7.67e-01	-0.007250	8.37e-01
Condensation of Prometaphase Chromosomes	11	9.67e-01	-0.007210	9.84e-01
Signaling by Non-Receptor Tyrosine Kinases	50	9.31e-01	-0.007120	9.61e-01
Signaling by PTK6	50	9.31e-01	-0.007120	9.61e-01
Interleukin-6 family signaling	19	9.58e-01	-0.006970	9.79e-01
RHO GTPase cycle	415	8.12e-01	-0.006820	8.73e-01
IRAK4 deficiency (TLR2/4)	15	9.64e-01	0.006810	9.82e-01
Purine salvage	13	9.68e-01	0.006520	9.84e-01
Signaling by EGFR	44	9.47e-01	0.005750	9.72e-01
Interleukin-37 signaling	20	9.66e-01	-0.005550	9.84e-01
Formation of apoptosome	11	9.76e-01	0.005300	9.88e-01
Regulation of the apoptosome activity	11	9.76e-01	0.005300	9.88e-01
MAPK1/MAPK3 signaling	238	8.91e-01	-0.005170	9.35e-01
EML4 and NUDC in mitotic spindle formation	96	9.31e-01	0.005150	9.61e-01
Transferrin endocytosis and recycling	26	9.67e-01	-0.004620	9.84e-01
Signaling by PDGF	56	9.53e-01	-0.004560	9.76e-01
ZBP1(DAI) mediated induction of type I IFNs	20	9.73e-01	-0.004370	9.88e-01
Regulation of KIT signaling	15	9.78e-01	-0.004110	9.90e-01
Signaling by ALK	26	9.71e-01	-0.004070	9.87e-01
IRF3-mediated induction of type I IFN	12	9.81e-01	-0.004040	9.90e-01
Dectin-2 family	13	9.81e-01	-0.003810	9.90e-01
Termination of O-glycan biosynthesis	13	9.81e-01	0.003780	9.90e-01
Activation of RAC1	11	9.83e-01	0.003630	9.90e-01
RAF/MAP kinase cascade	233	9.26e-01	-0.003550	9.60e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	10	9.86e-01	0.003280	9.90e-01
HDR through MMEJ (alt-NHEJ)	12	9.84e-01	-0.003250	9.90e-01
Signaling by VEGF	104	9.61e-01	0.002800	9.80e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	9.85e-01	0.002380	9.90e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	9.84e-01	0.002290	9.90e-01
RHO GTPase Effectors	236	9.53e-01	0.002240	9.76e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	80	9.75e-01	-0.002050	9.88e-01
Amplification of signal from the kinetochores	80	9.75e-01	-0.002050	9.88e-01
RHOQ GTPase cycle	56	9.82e-01	0.001790	9.90e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	9.92e-01	-0.001570	9.94e-01
Biosynthesis of DHA-derived SPMs	12	9.93e-01	0.001450	9.94e-01
Oncogenic MAPK signaling	76	9.85e-01	-0.001230	9.90e-01
p75 NTR receptor-mediated signalling	91	9.88e-01	-0.000931	9.91e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	11	9.96e-01	0.000898	9.96e-01
Signalling to ERKs	33	9.94e-01	-0.000723	9.95e-01
Signaling by Rho GTPases	589	9.81e-01	0.000579	9.90e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	603	9.93e-01	0.000220	9.94e-01

---

Detailed Gene set reports

Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin

	206
set	Cohesin Loading onto Chromatin
setSize	10
pANOVA	1.15e-05
s.dist	-0.801
p.adjustANOVA	0.000107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAG2	-9107
SMC1A	-8937
NIPBL	-8930
RAD21	-8569
WAPL	-8298
SMC3	-8069
PDS5A	-7642
STAG1	-5786
PDS5B	-5495
MAU2	-5163

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAG2	-9107
SMC1A	-8937
NIPBL	-8930
RAD21	-8569
WAPL	-8298
SMC3	-8069
PDS5A	-7642
STAG1	-5786
PDS5B	-5495
MAU2	-5163

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	424
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	7.71e-22
s.dist	-0.777
p.adjustANOVA	2.82e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476
EIF3F	-8392

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476
EIF3F	-8392
RPS11	-8273
EIF3D	-8215
RPS20	-7922
EIF3G	-7905
RPS25	-7825
RPS17	-7816
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPS14	-6574
EIF3B	-6339
RPS5	-6187
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPS3	-4984
RPS18	-4906
RPS27L	-3238
EIF3L	-1209
RPS26	577

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	416
set	Formation of a pool of free 40S subunits
setSize	100
pANOVA	1.03e-37
s.dist	-0.742
p.adjustANOVA	2.16e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
EIF3C	-8561
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
EIF3F	-8392
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
EIF3D	-8215
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EIF3G	-7905
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EIF3B	-6339
RPS5	-6187
RPLP1	-6159
EIF3K	-5872
EIF3J	-5790
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
EIF3L	-1209
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
RPL3	3020

---

SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery

	1093
set	SARS-CoV-1 modulates host translation machinery
setSize	36
pANOVA	2.55e-14
s.dist	-0.733
p.adjustANOVA	6.92e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
RPS24	-8637
RPS3A	-8610
RPS15	-8544
RPS6	-8538
RPS10	-8476
RPS11	-8273
RPS20	-7922
RPS25	-7825
RPS17	-7816
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
RPS24	-8637
RPS3A	-8610
RPS15	-8544
RPS6	-8538
RPS10	-8476
RPS11	-8273
RPS20	-7922
RPS25	-7825
RPS17	-7816
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPS14	-6574
RPS5	-6187
RPS3	-4984
RPS18	-4906
HNRNPA1	-4642
RPS27L	-3238
RPS26	577
EEF1A1	2882

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

	1086
set	Ribosomal scanning and start codon recognition
setSize	58
pANOVA	8.19e-22
s.dist	-0.728
p.adjustANOVA	2.92e-20

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476
EIF3F	-8392
RPS11	-8273
EIF3D	-8215
RPS20	-7922
EIF3G	-7905
RPS25	-7825
RPS17	-7816
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPS14	-6574
EIF3B	-6339
RPS5	-6187
EIF5	-6083
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4E	-4481
RPS27L	-3238
EIF4G1	-1413
EIF3L	-1209
RPS26	577
EIF4A1	4037

---

Viral mRNA Translation

Viral mRNA Translation

	1416
set	Viral mRNA Translation
setSize	88
pANOVA	5.17e-32
s.dist	-0.725
p.adjustANOVA	4.45e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
RPL23A	-4282
GRSF1	-3549
RPS27L	-3238
RPL12	-3022
DNAJC3	-2943
RPL14	-2377
RPL3L	-2329
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
RPL3	3020

---

Peptide chain elongation

Peptide chain elongation

	848
set	Peptide chain elongation
setSize	88
pANOVA	1.09e-31
s.dist	-0.721
p.adjustANOVA	8e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EEF2	-6569
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
EEF1A1	2882
RPL3	3020

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	461
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	111
pANOVA	2.3e-39
s.dist	-0.72
p.adjustANOVA	1.12e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
EIF3C	-8561
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
EIF3F	-8392
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
EIF3D	-8215
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EIF3G	-7905
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF5B	-7134
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EIF3B	-6339
RPS5	-6187
RPLP1	-6159
EIF5	-6083
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4E	-4481
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
EIF4G1	-1413
EIF3L	-1209
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
RPL3	3020
EIF4A1	4037

---

Translation initiation complex formation

Translation initiation complex formation

	1369
set	Translation initiation complex formation
setSize	58
pANOVA	3.7e-21
s.dist	-0.716
p.adjustANOVA	1.26e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476
EIF3F	-8392
RPS11	-8273
EIF3D	-8215
RPS20	-7922
EIF3G	-7905
RPS25	-7825
RPS17	-7816
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPS14	-6574
EIF3B	-6339
RPS5	-6187
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4E	-4481
RPS27L	-3238
EIF4G1	-1413
EIF3L	-1209
PABPC1	-423
RPS26	577
EIF4A1	4037

---

Selenocysteine synthesis

Selenocysteine synthesis

	1138
set	Selenocysteine synthesis
setSize	92
pANOVA	2.02e-32
s.dist	-0.714
p.adjustANOVA	1.97e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
SEPHS2	-7380
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
SECISBP2	-7297
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
RPL23A	-4282
SARS1	-3598
EEFSEC	-3449
RPS27L	-3238
RPL12	-3022
PSTK	-2403
RPL14	-2377
RPL3L	-2329
SEPSECS	-1617
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
RPL3	3020

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	621
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	110
pANOVA	2.41e-38
s.dist	-0.713
p.adjustANOVA	5.89e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
EIF3C	-8561
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
EIF3F	-8392
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
EIF3D	-8215
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EIF3G	-7905
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EIF3B	-6339
RPS5	-6187
RPLP1	-6159
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4E	-4481
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
EIF4G1	-1413
EIF3L	-1209
PABPC1	-423
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
RPL3	3020
EIF4A1	4037

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	52
set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	59
pANOVA	3.17e-21
s.dist	-0.711
p.adjustANOVA	1.1e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
EIF3A	-8865
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPS24	-8637
RPS3A	-8610
EIF3C	-8561
RPS15	-8544
RPS6	-8538
RPS10	-8476
EIF3F	-8392
RPS11	-8273
EIF3D	-8215
RPS20	-7922
EIF3G	-7905
RPS25	-7825
RPS17	-7816
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPS14	-6574
EIF3B	-6339
RPS5	-6187
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4EBP1	-4509
EIF4E	-4481
RPS27L	-3238
EIF4G1	-1413
EIF3L	-1209
PABPC1	-423
RPS26	577
EIF4A1	4037

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	373
set	Eukaryotic Translation Termination
setSize	92
pANOVA	4.28e-32
s.dist	-0.71
p.adjustANOVA	3.92e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
GSPT1	-5112
RPS3	-4984
APEH	-4956
RPS18	-4906
TRMT112	-4666
RPL23A	-4282
ETF1	-3370
RPS27L	-3238
RPL12	-3022
N6AMT1	-2920
RPL14	-2377
RPL3L	-2329
GSPT2	-1860
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
RPL3	3020

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	371
set	Eukaryotic Translation Elongation
setSize	93
pANOVA	8.51e-32
s.dist	-0.703
p.adjustANOVA	6.56e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
EEF1D	-8834
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
EEF1D	-8834
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
EEF1B2	-8057
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EEF2	-6569
EEF1G	-6397
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
EEF1A2	-1314
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
EEF1A1	2882
RPL3	3020
EEF1A1P5	4167

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

	368
set	Establishment of Sister Chromatid Cohesion
setSize	10
pANOVA	0.000123
s.dist	-0.701
p.adjustANOVA	0.000841

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STAG2	-9107
SMC1A	-8937
RAD21	-8569
WAPL	-8298
SMC3	-8069
PDS5A	-7642
STAG1	-5786
PDS5B	-5495
ESCO2	-3037
ESCO1	-2808

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STAG2	-9107
SMC1A	-8937
RAD21	-8569
WAPL	-8298
SMC3	-8069
PDS5A	-7642
STAG1	-5786
PDS5B	-5495
ESCO2	-3037
ESCO1	-2808

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	780
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	94
pANOVA	2.21e-31
s.dist	-0.695
p.adjustANOVA	1.54e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
UPF1	-9170
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
UPF1	-9170
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
NCBP1	-5334
GSPT1	-5112
RPS3	-4984
RPS18	-4906
RPL23A	-4282
ETF1	-3370
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
GSPT2	-1860
EIF4G1	-1413
PABPC1	-423
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
NCBP2	2415
RPL26L1	2574
RPL3	3020

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	154
set	Cap-dependent Translation Initiation
setSize	118
pANOVA	2.18e-38
s.dist	-0.689
p.adjustANOVA	5.89e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
EIF3C	-8561
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
EIF3F	-8392
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
EIF3D	-8215
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EIF3G	-7905
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF5B	-7134
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EIF3B	-6339
RPS5	-6187
RPLP1	-6159
EIF2B5	-6139
EIF5	-6083
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPL27A	-5778
RPL36A	-5540
EIF2B3	-5301
EIF2B4	-5281
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4EBP1	-4509
EIF4E	-4481
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
EIF4G1	-1413
EIF3L	-1209
PABPC1	-423
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
EIF2B2	1401
EIF2B1	1899
RPL26L1	2574
RPL3	3020
EIF4A1	4037

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	372
set	Eukaryotic Translation Initiation
setSize	118
pANOVA	2.18e-38
s.dist	-0.689
p.adjustANOVA	5.89e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
RPL19	-8835
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
EIF4B	-8662
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
EIF3C	-8561
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
EIF3F	-8392
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
EIF3D	-8215
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EIF3G	-7905
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
EIF3M	-7495
EIF1AX	-7473
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
EIF5B	-7134
EIF4A2	-7132
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
EIF3B	-6339
RPS5	-6187
RPLP1	-6159
EIF2B5	-6139
EIF5	-6083
EIF2S2	-5971
EIF3K	-5872
EIF3J	-5790
RPL27A	-5778
RPL36A	-5540
EIF2B3	-5301
EIF2B4	-5281
RPS3	-4984
RPS18	-4906
EIF4H	-4542
EIF4EBP1	-4509
EIF4E	-4481
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
EIF4G1	-1413
EIF3L	-1209
PABPC1	-423
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
EIF2B2	1401
EIF2B1	1899
RPL26L1	2574
RPL3	3020
EIF4A1	4037

---

PINK1-PRKN Mediated Mitophagy

PINK1-PRKN Mediated Mitophagy

	828
set	PINK1-PRKN Mediated Mitophagy
setSize	21
pANOVA	7.32e-08
s.dist	-0.678
p.adjustANOVA	1.12e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATG12	-9158
TOMM6	-8911
MAP1LC3A	-8317
TOMM7	-8063
UBA52	-8015
TOMM5	-7985
MFN1	-7734
TOMM22	-7514
ATG5	-7494
TOMM40	-7344
RPS27A	-7158
TOMM20	-7042
TOMM70	-6875
SQSTM1	-6468
UBB	-5814
UBC	-4857
PINK1	-4645
MTERF3	-4593
MFN2	-4404
VDAC1	-3459

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATG12	-9158
TOMM6	-8911
MAP1LC3A	-8317
TOMM7	-8063
UBA52	-8015
TOMM5	-7985
MFN1	-7734
TOMM22	-7514
ATG5	-7494
TOMM40	-7344
RPS27A	-7158
TOMM20	-7042
TOMM70	-6875
SQSTM1	-6468
UBB	-5814
UBC	-4857
PINK1	-4645
MTERF3	-4593
MFN2	-4404
VDAC1	-3459
MAP1LC3B	-2392

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1079
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	100
pANOVA	5.41e-31
s.dist	-0.669
p.adjustANOVA	3.44e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
DDIT3	-8037
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
EIF2AK4	-7745
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
ATF4	-6991
ATF2	-6807
RPS19	-6727
RPL17	-6676
RPS14	-6574
RPS5	-6187
RPLP1	-6159
EIF2S2	-5971
GCN1	-5884
RPL27A	-5778
RPL36A	-5540
RPS3	-4984
RPS18	-4906
RPL23A	-4282
RPS27L	-3238
RPL12	-3022
RPL14	-2377
RPL3L	-2329
CEBPB	-1995
CEBPG	-856
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
IMPACT	2367
RPL26L1	2574
RPL3	3020
TRIB3	3220
ATF3	5044
ASNS	6691

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

	375
set	Expression and translocation of olfactory receptors
setSize	25
pANOVA	1.03e-08
s.dist	0.661
p.adjustANOVA	1.81e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR10G3	7119
OR1D2	6907
OR52K1	6891
OR4D9	6523
OR5AN1	6519
OR6Y1	6248
OR2AT4	6247
OR6C75	6168
OR5A2	6089
OR2M3	5964
OR51E1	5679
OR7C1	5354
OR56A1	5226
OR14J1	5107
OR5AU1	4763
OR5AS1	4493
OR5A1	4272
REEP1	4206
EBF1	4030
OR8A1	3804

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR10G3	7119
OR1D2	6907
OR52K1	6891
OR4D9	6523
OR5AN1	6519
OR6Y1	6248
OR2AT4	6247
OR6C75	6168
OR5A2	6089
OR2M3	5964
OR51E1	5679
OR7C1	5354
OR56A1	5226
OR14J1	5107
OR5AU1	4763
OR5AS1	4493
OR5A1	4272
REEP1	4206
EBF1	4030
OR8A1	3804
OR2V2	3667
OR1I1	3257
LDB1	-1450
OR7D2	-1737
OR10H5	-3722

---

SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery

	1099
set	SARS-CoV-2 modulates host translation machinery
setSize	49
pANOVA	3.3e-15
s.dist	-0.65
p.adjustANOVA	9.1e-14

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMN1	-9207
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
RPS24	-8637
RPS3A	-8610
RPS15	-8544
RPS6	-8538
RPS10	-8476
SNRPG	-8415
RPS11	-8273
SNRPF	-8202
SNRPB	-8171
RPS20	-7922
RPS25	-7825

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMN1	-9207
RPSA	-9069
RPS27	-9023
RPS21	-8956
RPS29	-8889
RPS23	-8794
FAU	-8778
RPS16	-8752
RPS15A	-8723
RPS24	-8637
RPS3A	-8610
RPS15	-8544
RPS6	-8538
RPS10	-8476
SNRPG	-8415
RPS11	-8273
SNRPF	-8202
SNRPB	-8171
RPS20	-7922
RPS25	-7825
RPS17	-7816
GEMIN5	-7765
RPS12	-7764
RPS9	-7651
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPS14	-6574
RPS5	-6187
SNRPD3	-5542
RPS3	-4984
RPS18	-4906
SNRPD2	-4517
GEMIN7	-3951
RPS27L	-3238
GEMIN4	-2768
GEMIN6	-2759
SNRPE	-2750
SNRPD1	-2680
RPS26	577
GEMIN2	750
DDX20	3136
GEMIN8	3434

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	779
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	114
pANOVA	1.22e-32
s.dist	-0.644
p.adjustANOVA	1.28e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
UPF1	-9170
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
MAGOH	-8779
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
UPF1	-9170
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
MAGOH	-8779
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
SMG7	-8611
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
UPF3B	-8403
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
SMG1	-8267
UPF2	-8225
PNRC2	-8209
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
CASC3	-7613
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
PPP2CA	-6239
RPS5	-6187
RPLP1	-6159
DCP1A	-6158
RPL27A	-5778
RPL36A	-5540
NCBP1	-5334
GSPT1	-5112
RPS3	-4984
RPS18	-4906
SMG5	-4419
RPL23A	-4282
RBM8A	-3948
SMG6	-3927
ETF1	-3370
RNPS1	-3368
RPS27L	-3238
UPF3A	-3033
RPL12	-3022
PPP2R2A	-2700
EIF4A3	-2560
RPL14	-2377
RPL3L	-2329
GSPT2	-1860
PPP2R1A	-1738
EIF4G1	-1413
PABPC1	-423
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
SMG9	848
NCBP2	2415
RPL26L1	2574
RPL3	3020
SMG8	4077
MAGOHB	5294

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	781
set	Nonsense-Mediated Decay (NMD)
setSize	114
pANOVA	1.22e-32
s.dist	-0.644
p.adjustANOVA	1.28e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
UPF1	-9170
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
MAGOH	-8779
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
UPF1	-9170
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
MAGOH	-8779
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
SMG7	-8611
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
UPF3B	-8403
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
SMG1	-8267
UPF2	-8225
PNRC2	-8209
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
CASC3	-7613
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
PPP2CA	-6239
RPS5	-6187
RPLP1	-6159
DCP1A	-6158
RPL27A	-5778
RPL36A	-5540
NCBP1	-5334
GSPT1	-5112
RPS3	-4984
RPS18	-4906
SMG5	-4419
RPL23A	-4282
RBM8A	-3948
SMG6	-3927
ETF1	-3370
RNPS1	-3368
RPS27L	-3238
UPF3A	-3033
RPL12	-3022
PPP2R2A	-2700
EIF4A3	-2560
RPL14	-2377
RPL3L	-2329
GSPT2	-1860
PPP2R1A	-1738
EIF4G1	-1413
PABPC1	-423
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
SMG9	848
NCBP2	2415
RPL26L1	2574
RPL3	3020
SMG8	4077
MAGOHB	5294

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1137
set	Selenoamino acid metabolism
setSize	114
pANOVA	8.23e-32
s.dist	-0.636
p.adjustANOVA	6.56e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
AIMP1	-9145
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
DARS1	-8824
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
AIMP1	-9145
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
DARS1	-8824
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
LARS1	-8512
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
RARS1	-8023
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EPRS1	-7904
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
SEPHS2	-7380
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
SECISBP2	-7297
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
MARS1	-7121
RPS13	-7092
RPS19	-6727
RPL17	-6676
RPS14	-6574
CTH	-6517
NNMT	-6386
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
RPL36A	-5540
IARS1	-5019
RPS3	-4984
RPS18	-4906
AIMP2	-4881
RPL23A	-4282
QARS1	-3846
SARS1	-3598
EEFSEC	-3449
KARS1	-3401
AHCY	-3361
RPS27L	-3238
RPL12	-3022
PSTK	-2403
RPL14	-2377
RPL3L	-2329
GSR	-1959
PAPSS2	-1734
SCLY	-1647
SEPSECS	-1617
HNMT	-1539
TXNRD1	-331
RPLP0	-196
RPL39L	-143
RPS26	577
RPL22L1	602
RPL26L1	2574
INMT	2667
RPL3	3020
EEF1E1	3162
PAPSS1	3657
CBS	4235

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1118
set	SRP-dependent cotranslational protein targeting to membrane
setSize	111
pANOVA	2.59e-30
s.dist	-0.628
p.adjustANOVA	1.58e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
SRP14	-8598
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
SSR3	-8474
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
SRPRA	-7569
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
SEC11A	-7378
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
SRP68	-7027
RPS19	-6727
RPL17	-6676
RPS14	-6574
RPS5	-6187
RPLP1	-6159
SRP9	-6031
SEC61A2	-5807
RPL27A	-5778
RPL36A	-5540
SEC61G	-5225
RPS3	-4984
RPS18	-4906
SPCS3	-4843
SSR2	-4317
DDOST	-4291
RPL23A	-4282
SRP72	-3622
SPCS2	-3566
RPS27L	-3238
SEC61B	-3133
RPL12	-3022
RPN1	-2564
RPL14	-2377
RPL3L	-2329
SEC11C	-1673
SRPRB	-1181
SEC61A1	-1010
TRAM1	-864
RPN2	-646
SSR1	-282
RPLP0	-196
RPL39L	-143
SRP54	-5
RPS26	577
RPL22L1	602
SPCS1	2080
RPL26L1	2574
RPL3	3020
SSR4	3336
SRP19	5993

---

Mitophagy

Mitophagy

	708
set	Mitophagy
setSize	28
pANOVA	1.5e-08
s.dist	-0.618
p.adjustANOVA	2.53e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATG12	-9158
TOMM6	-8911
CSNK2A2	-8671
MAP1LC3A	-8317
TOMM7	-8063
UBA52	-8015
TOMM5	-7985
ULK1	-7767
MFN1	-7734
TOMM22	-7514
ATG5	-7494
TOMM40	-7344
RPS27A	-7158
CSNK2B	-7151
TOMM20	-7042
TOMM70	-6875
CSNK2A1	-6826
SQSTM1	-6468
UBB	-5814
UBC	-4857

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATG12	-9158
TOMM6	-8911
CSNK2A2	-8671
MAP1LC3A	-8317
TOMM7	-8063
UBA52	-8015
TOMM5	-7985
ULK1	-7767
MFN1	-7734
TOMM22	-7514
ATG5	-7494
TOMM40	-7344
RPS27A	-7158
CSNK2B	-7151
TOMM20	-7042
TOMM70	-6875
CSNK2A1	-6826
SQSTM1	-6468
UBB	-5814
UBC	-4857
FUNDC1	-4734
PINK1	-4645
MTERF3	-4593
MFN2	-4404
VDAC1	-3459
MAP1LC3B	-2392
PGAM5	514
SRC	2567

---

Common Pathway of Fibrin Clot Formation

Common Pathway of Fibrin Clot Formation

	211
set	Common Pathway of Fibrin Clot Formation
setSize	11
pANOVA	0.000486
s.dist	0.607
p.adjustANOVA	0.00266

Top enriched genes

Top 20 genes

GeneID	Gene Rank
F13A1	6621
SERPINE2	6504
PF4	6150
F2R	5807
F5	5478
F10	5355
THBD	4047
PROS1	3322
PROCR	3157
SERPINA5	2655
F8	-4842

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
F13A1	6621
SERPINE2	6504
PF4	6150
F2R	5807
F5	5478
F10	5355
THBD	4047
PROS1	3322
PROCR	3157
SERPINA5	2655
F8	-4842

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

	407
set	Formation of ATP by chemiosmotic coupling
setSize	16
pANOVA	3.99e-05
s.dist	-0.593
p.adjustANOVA	0.000301

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5F1E	-8877
ATP5ME	-8728
ATP5MG	-8231
ATP5MF	-7330
ATP5PD	-7238
ATP5PB	-6099
ATP5PO	-5955
ATP5MC3	-5706
ATP5MC1	-5616
ATP5PF	-5598
ATP5F1D	-5435
ATP5MC2	-4894
ATP5F1A	-4610
ATP5F1B	-3894
ATP5F1C	-3741
DMAC2L	-2145

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5F1E	-8877
ATP5ME	-8728
ATP5MG	-8231
ATP5MF	-7330
ATP5PD	-7238
ATP5PB	-6099
ATP5PO	-5955
ATP5MC3	-5706
ATP5MC1	-5616
ATP5PF	-5598
ATP5F1D	-5435
ATP5MC2	-4894
ATP5F1A	-4610
ATP5F1B	-3894
ATP5F1C	-3741
DMAC2L	-2145

---

Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation

	1018
set	Regulation of FOXO transcriptional activity by acetylation
setSize	10
pANOVA	0.00117
s.dist	-0.593
p.adjustANOVA	0.00558

Top enriched genes

Top 20 genes

GeneID	Gene Rank
EP300	-9148
SIRT1	-9093
FOXO3	-8776
KAT2B	-7840
FOXO1	-7526
CREBBP	-5698
TXNIP	-4759
SIRT3	-4550
FOXO4	-4161
TXN	2767

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
EP300	-9148
SIRT1	-9093
FOXO3	-8776
KAT2B	-7840
FOXO1	-7526
CREBBP	-5698
TXNIP	-4759
SIRT3	-4550
FOXO4	-4161
TXN	2767

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

	803
set	Olfactory Signaling Pathway
setSize	29
pANOVA	3.34e-08
s.dist	0.592
p.adjustANOVA	5.26e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR10G3	7119
ADCY3	6928
OR1D2	6907
OR52K1	6891
OR4D9	6523
OR5AN1	6519
OR6Y1	6248
OR2AT4	6247
OR6C75	6168
OR5A2	6089
OR2M3	5964
OR51E1	5679
OR7C1	5354
OR56A1	5226
OR14J1	5107
OR5AU1	4763
OR5AS1	4493
OR5A1	4272
REEP1	4206
EBF1	4030

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR10G3	7119
ADCY3	6928
OR1D2	6907
OR52K1	6891
OR4D9	6523
OR5AN1	6519
OR6Y1	6248
OR2AT4	6247
OR6C75	6168
OR5A2	6089
OR2M3	5964
OR51E1	5679
OR7C1	5354
OR56A1	5226
OR14J1	5107
OR5AU1	4763
OR5AS1	4493
OR5A1	4272
REEP1	4206
EBF1	4030
OR8A1	3804
OR2V2	3667
OR1I1	3257
GNB1	1364
LDB1	-1450
OR7D2	-1737
ANO2	-3154
OR10H5	-3722
GNAL	-3836

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

	559
set	Influenza Viral RNA Transcription and Replication
setSize	135
pANOVA	4.32e-30
s.dist	-0.568
p.adjustANOVA	2.53e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
HSP90AA1	-8943
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
HSP90AA1	-8943
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RANBP2	-8628
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
GTF2F1	-8540
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
POLR2F	-8470
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
POLR2L	-8103
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
NUP98	-7680
RPL36AL	-7677
RPS9	-7651
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
GTF2F2	-7325
RPL10A	-7319
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
NUP54	-7060
NUP58	-6798
NUP160	-6761
RPS19	-6727
RPL17	-6676
RPS14	-6574
SEC13	-6317
NUP37	-6292
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
NUP133	-5771
NUP153	-5691
NUP50	-5632
RPL36A	-5540
NUP210	-5396
POLR2I	-5309
POLR2B	-5288
IPO5	-5262
NUP188	-5218
NUP42	-5201
PARP1	-5170
NUP205	-5042
RPS3	-4984
RPS18	-4906
POLR2A	-4758
RPL23A	-4282
NUP93	-4260
RAE1	-3893
POLR2C	-3742
GRSF1	-3549
RPS27L	-3238
RPL12	-3022
NUP62	-2956
DNAJC3	-2943
POLR2J	-2719
TPR	-2493
RPL14	-2377
POM121C	-2353
RPL3L	-2329
POM121	-863
NUP155	-830
POLR2K	-326
POLR2E	-285
NUP107	-257
NUP35	-211
RPLP0	-196
RPL39L	-143
POLR2G	121
RPS26	577
RPL22L1	602
NUP88	790
NUP214	985
SEH1L	1613
RPL26L1	2574
AAAS	2639
POLR2D	2746
RPL3	3020
NUP43	4730
POLR2H	5035
NUP85	5357
NDC1	6027

---

Cellular response to starvation

Cellular response to starvation

	181
set	Cellular response to starvation
setSize	148
pANOVA	2.33e-31
s.dist	-0.554
p.adjustANOVA	1.55e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
RPSA	-9069
RRAGB	-9059
KPTN	-9057
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
LAMTOR1	-8803
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
EIF2S3	-9153
RPSA	-9069
RRAGB	-9059
KPTN	-9057
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
LAMTOR1	-8803
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
RRAGA	-8372
RPL35A	-8364
FNIP1	-8332
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
DDIT3	-8037
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
EIF2AK4	-7745
RPL23	-7726
WDR24	-7682
RPL36AL	-7677
RPS9	-7651
BMT2	-7650
ATP6V0E1	-7592
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
LAMTOR3	-7300
ATP6V1G1	-7278
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
LAMTOR4	-7197
RPS28	-7167
RPS27A	-7158
RPS2	-7146
SESN1	-7144
RPS13	-7092
ATF4	-6991
ATF2	-6807
RPS19	-6727
RPL17	-6676
RPS14	-6574
ATP6V0C	-6499
MIOS	-6437
SEC13	-6317
RPS5	-6187
RPLP1	-6159
EIF2S2	-5971
GCN1	-5884
MTOR	-5874
RPL27A	-5778
LAMTOR5	-5664
MLST8	-5640
RHEB	-5629
RPL36A	-5540
ITFG2	-5516
ATP6V1C1	-5445
LAMTOR2	-5357
ATP6V1B2	-5157
ATP6V0E2	-5021
RPS3	-4984
RPS18	-4906
RPL23A	-4282
NPRL3	-4016
FLCN	-3406
ATP6V0D1	-3311
RPS27L	-3238
RPL12	-3022
NPRL2	-2954
RRAGD	-2891
ATP6V1E2	-2563
ATP6V1D	-2542
RPL14	-2377
RPL3L	-2329
CEBPB	-1995
RRAGC	-1559
ATP6V0B	-1434
WDR59	-1293
CEBPG	-856
ATP6V1H	-643
ATP6V1A	-601
ATP6V1E1	-442
RPLP0	-196
RPL39L	-143
SESN2	-19
ATP6V1F	568
RPS26	577
RPL22L1	602
FNIP2	717
SLC38A9	727
SEH1L	1613
SH3BP4	2277
IMPACT	2367
DEPDC5	2471
RPTOR	2481
ATP6V1C2	2495
RPL26L1	2574
RPL3	3020
SZT2	3073
TRIB3	3220
ATF3	5044
TCIRG1	5752
ASNS	6691

---

Translation

Translation

	1368
set	Translation
setSize	292
pANOVA	1.17e-59
s.dist	-0.553
p.adjustANOVA	8.54e-57

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
MRPL54	-9175
EIF2S3	-9153
AIMP1	-9145
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
MRPL48	-8950
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
MRPL22	-8839
RPL19	-8835
EEF1D	-8834
DARS1	-8824

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
MRPL54	-9175
EIF2S3	-9153
AIMP1	-9145
EIF3E	-9125
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
MRPL48	-8950
RPL35	-8896
RPS29	-8889
EIF3A	-8865
RPL5	-8844
MRPL22	-8839
RPL19	-8835
EEF1D	-8834
DARS1	-8824
EIF3I	-8804
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
EIF3H	-8715
MRPS30	-8683
EIF4B	-8662
RPL26	-8660
RPS24	-8637
YARS2	-8617
RPS3A	-8610
RPL21	-8604
RPL22	-8602
SRP14	-8598
RPL38	-8575
EIF3C	-8561
RPL30	-8551
PPA2	-8547
RPS15	-8544
MRPS5	-8542
RPS6	-8538
LARS1	-8512
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
SSR3	-8474
MRPL34	-8468
RPL36	-8458
MRPS2	-8420
EIF3F	-8392
RPL35A	-8364
PPA1	-8339
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
MRPL13	-8240
EIF3D	-8215
RPL37A	-8193
RPL29	-8173
CARS2	-8147
MRPL9	-8107
MRPS17	-8104
RPL11	-8081
IARS2	-8066
MRPS36	-8062
EEF1B2	-8057
HARS2	-8046
RPL24	-8040
RARS1	-8023
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
EIF3G	-7905
EPRS1	-7904
MTRF1L	-7895
RPL41	-7858
RPS25	-7825
RPS17	-7816
MRPL28	-7802
RPL13A	-7782
RPS12	-7764
RPL6	-7750
CHCHD1	-7733
RPL23	-7726
WARS2	-7683
RPL36AL	-7677
RPS9	-7651
SRPRA	-7569
TUFM	-7564
MRPS34	-7562
RPLP2	-7545
RPS4Y1	-7535
MRPL30	-7505
MRPL51	-7503
EIF3M	-7495
EIF1AX	-7473
NARS1	-7454
RPS8	-7427
SEC11A	-7378
MRPL19	-7376
RPS4X	-7375
RPS7	-7364
MRPL32	-7346
MRPL47	-7343
RPL10A	-7319
MRPL27	-7283
RPL28	-7270
RPL18	-7257
EIF2S1	-7203
RPS28	-7167
MRPL12	-7164
RPS27A	-7158
GARS1	-7155
RPS2	-7146
EIF5B	-7134
EIF4A2	-7132
MARS1	-7121
RPS13	-7092
MRPS27	-7037
GADD45GIP1	-7031
SRP68	-7027
MRPL16	-6987
MRPL18	-6934
MRPL58	-6870
MRPL4	-6846
MRPL52	-6792
RPS19	-6727
RPL17	-6676
MRPL57	-6665
MRPL46	-6656
AARS1	-6599
RPS14	-6574
EEF2	-6569
MRPS21	-6507
MRPL42	-6451
MRPL1	-6405
EEF1G	-6397
TARS1	-6379
EIF3B	-6339
MRPS25	-6310
MRPL11	-6283
DARS2	-6210
MRPS14	-6190
RPS5	-6187
RPLP1	-6159
MRPS15	-6153
EIF2B5	-6139
DAP3	-6131
MRRF	-6096
EIF5	-6083
SRP9	-6031
EIF2S2	-5971
MRPS9	-5883
EIF3K	-5872
MRPL41	-5867
SEC61A2	-5807
EIF3J	-5790
RPL27A	-5778
MRPL21	-5747
MRPL24	-5724
MTIF3	-5720
MRPL45	-5609
MTIF2	-5550
PTCD3	-5547
RPL36A	-5540
MRPS16	-5488
MRPL33	-5487
MRPL38	-5462
MRPL37	-5453
MRPL15	-5432
MRPL44	-5420
EIF2B3	-5301
MRPS26	-5293
EIF2B4	-5281
SEC61G	-5225
GSPT1	-5112
RARS2	-5110
MRPS18B	-5089
GFM1	-5050
IARS1	-5019
FARSA	-5005
RPS3	-4984
MTFMT	-4965
APEH	-4956
RPS18	-4906
AIMP2	-4881
MRPL17	-4871
SPCS3	-4843
MRPL2	-4827
LARS2	-4826
MRPL39	-4731
OXA1L	-4723
TRMT112	-4666
MRPS22	-4603
MRPS11	-4578
EIF4H	-4542
EIF4EBP1	-4509
EIF4E	-4481
YARS1	-4345
MRPL53	-4339
MRPS18A	-4326
SSR2	-4317
DDOST	-4291
RPL23A	-4282
MRPS35	-4276
AURKAIP1	-4245
MARS2	-4181
TARS2	-4097
MRPL35	-4049
MRPS33	-4027
MRPL20	-3969
MRPS10	-3918
GFM2	-3914
QARS1	-3846
MRPL55	-3816
TSFM	-3735
MRPS12	-3716
SRP72	-3622
SARS1	-3598
SPCS2	-3566
KARS1	-3401
ETF1	-3370
RPS27L	-3238
CARS1	-3231
MRPS7	-3161
MRPS24	-3150
SEC61B	-3133
MRPL49	-3106
MRPL10	-3084
RPL12	-3022
N6AMT1	-2920
MRPL36	-2733
SARS2	-2692
FARSB	-2570
RPN1	-2564
MRPS23	-2539
ERAL1	-2519
MRPS28	-2436
RPL14	-2377
RPL3L	-2329
MRPL40	-2188
MRPL43	-2122
MRPL50	-2063
NARS2	-1917
GSPT2	-1860
SEC11C	-1673
EIF4G1	-1413
MRPL14	-1341
EEF1A2	-1314
EIF3L	-1209
SRPRB	-1181
MRPS18C	-1155
FARS2	-1137
SEC61A1	-1010
TRAM1	-864
RPN2	-646
EARS2	-568
MRPL23	-454
PABPC1	-423
SSR1	-282
RPLP0	-196
RPL39L	-143
WARS1	-105
SRP54	-5
AARS2	-2
MRPL3	494
RPS26	577
RPL22L1	602
PARS2	655
VARS1	831
EIF2B2	1401
MRPS31	1430
EIF2B1	1899
SPCS1	2080
HARS1	2405
RPL26L1	2574
EEF1A1	2882
RPL3	3020
EEF1E1	3162
SSR4	3336
EIF4A1	4037
EEF1A1P5	4167
MRPS6	4951
VARS2	5425
SRP19	5993

---

Cristae formation

Cristae formation

	230
set	Cristae formation
setSize	29
pANOVA	4.03e-07
s.dist	-0.544
p.adjustANOVA	5.61e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATP5F1E	-8877
ATP5ME	-8728
ATP5MG	-8231
ATP5MF	-7330
ATP5PD	-7238
DNAJC11	-7230
HSPA9	-6518
MICOS10	-6516
MICOS13	-6415
APOOL	-6358
ATP5PB	-6099
SAMM50	-6028
ATP5PO	-5955
ATP5MC3	-5706
ATP5MC1	-5616
ATP5PF	-5598
ATP5F1D	-5435
MTX1	-5425
CHCHD6	-5326
ATP5MC2	-4894

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATP5F1E	-8877
ATP5ME	-8728
ATP5MG	-8231
ATP5MF	-7330
ATP5PD	-7238
DNAJC11	-7230
HSPA9	-6518
MICOS10	-6516
MICOS13	-6415
APOOL	-6358
ATP5PB	-6099
SAMM50	-6028
ATP5PO	-5955
ATP5MC3	-5706
ATP5MC1	-5616
ATP5PF	-5598
ATP5F1D	-5435
MTX1	-5425
CHCHD6	-5326
ATP5MC2	-4894
CHCHD3	-4867
ATP5F1A	-4610
ATP5F1B	-3894
MTX2	-3782
ATP5F1C	-3741
APOO	-3321
IMMT	-2166
DMAC2L	-2145
TMEM11	-562

---

Complex I biogenesis

Complex I biogenesis

	214
set	Complex I biogenesis
setSize	51
pANOVA	2.08e-11
s.dist	-0.542
p.adjustANOVA	4.68e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NDUFA3	-8846
NDUFA13	-8067
NDUFB1	-8003
NDUFS5	-7980
ACAD9	-7909
NDUFA1	-7698
NDUFA5	-7269
NDUFB6	-7222
ECSIT	-7191
NDUFAF3	-7123
NDUFB7	-7112
NDUFS6	-7098
NDUFAF7	-7081
NDUFB3	-7055
NDUFA2	-6890
NUBPL	-6772
NDUFAF2	-6732
NDUFB11	-6297
NDUFS4	-6030
TMEM126B	-6018

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NDUFA3	-8846
NDUFA13	-8067
NDUFB1	-8003
NDUFS5	-7980
ACAD9	-7909
NDUFA1	-7698
NDUFA5	-7269
NDUFB6	-7222
ECSIT	-7191
NDUFAF3	-7123
NDUFB7	-7112
NDUFS6	-7098
NDUFAF7	-7081
NDUFB3	-7055
NDUFA2	-6890
NUBPL	-6772
NDUFAF2	-6732
NDUFB11	-6297
NDUFS4	-6030
TMEM126B	-6018
NDUFV1	-5939
NDUFAF4	-5911
NDUFB4	-5862
NDUFAB1	-5813
NDUFA9	-5531
NDUFS8	-5514
NDUFB2	-5440
NDUFB8	-5236
NDUFS3	-5200
NDUFA6	-5145
TIMMDC1	-5100
NDUFA8	-5082
NDUFA12	-5058
NDUFC2	-5013
NDUFB5	-4794
NDUFA11	-4742
NDUFS7	-4717
NDUFA10	-4614
NDUFB10	-4599
NDUFV2	-4583
NDUFV3	-4416
NDUFAF5	-3963
NDUFC1	-3785
TMEM186	-3467
COA1	-3444
NDUFS1	-3379
NDUFS2	-3012
NDUFB9	-2423
NDUFAF6	-1592
NDUFA7	-1474
NDUFAF1	1210

---

Respiratory electron transport

Respiratory electron transport

	1076
set	Respiratory electron transport
setSize	93
pANOVA	3.66e-19
s.dist	-0.537
p.adjustANOVA	1.22e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COX7A2L	-8906
NDUFA3	-8846
ETFDH	-8196
NDUFA13	-8067
UQCRB	-8044
NDUFB1	-8003
NDUFS5	-7980
ACAD9	-7909
NDUFA1	-7698
COX19	-7513
NDUFA5	-7269
NDUFB6	-7222
UQCRH	-7220
ECSIT	-7191
SDHD	-7137
NDUFAF3	-7123
NDUFB7	-7112
NDUFS6	-7098
NDUFAF7	-7081
NDUFB3	-7055

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COX7A2L	-8906
NDUFA3	-8846
ETFDH	-8196
NDUFA13	-8067
UQCRB	-8044
NDUFB1	-8003
NDUFS5	-7980
ACAD9	-7909
NDUFA1	-7698
COX19	-7513
NDUFA5	-7269
NDUFB6	-7222
UQCRH	-7220
ECSIT	-7191
SDHD	-7137
NDUFAF3	-7123
NDUFB7	-7112
NDUFS6	-7098
NDUFAF7	-7081
NDUFB3	-7055
COX16	-7034
NDUFA2	-6890
COX4I1	-6885
SCO1	-6863
COX11	-6850
NUBPL	-6772
COX7C	-6734
NDUFAF2	-6732
COX6B1	-6548
SURF1	-6412
SDHC	-6395
CYCS	-6361
UQCR11	-6321
NDUFB11	-6297
LRPPRC	-6094
COX18	-6055
NDUFS4	-6030
TMEM126B	-6018
TACO1	-6011
NDUFV1	-5939
ETFB	-5922
NDUFAF4	-5911
NDUFB4	-5862
UQCR10	-5858
NDUFAB1	-5813
SDHB	-5717
COX5A	-5712
COX5B	-5661
NDUFA9	-5531
NDUFS8	-5514
COX7B	-5472
NDUFB2	-5440
UQCRQ	-5274
NDUFB8	-5236
UQCRFS1	-5204
NDUFS3	-5200
NDUFA6	-5145
CYC1	-5107
TIMMDC1	-5100
NDUFA8	-5082
NDUFA12	-5058
UQCRC2	-5018
NDUFC2	-5013
SDHA	-4816
NDUFB5	-4794
NDUFA11	-4742
NDUFS7	-4717
NDUFA10	-4614
NDUFB10	-4599
NDUFV2	-4583
COX8A	-4434
NDUFV3	-4416
COX6C	-4251
ETFA	-4099
NDUFA4	-4050
NDUFAF5	-3963
NDUFC1	-3785
TRAP1	-3690
UQCRC1	-3562
COX14	-3557
TMEM186	-3467
COA1	-3444
NDUFS1	-3379
NDUFS2	-3012
COQ10A	-2975
SCO2	-2688
NDUFB9	-2423
NDUFAF6	-1592
NDUFA7	-1474
COX6A1	-390
COQ10B	303
COX20	1152
NDUFAF1	1210

---

Receptor Mediated Mitophagy

Receptor Mediated Mitophagy

	997
set	Receptor Mediated Mitophagy
setSize	11
pANOVA	0.00212
s.dist	-0.535
p.adjustANOVA	0.00888

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ATG12	-9158
CSNK2A2	-8671
MAP1LC3A	-8317
ULK1	-7767
ATG5	-7494
CSNK2B	-7151
CSNK2A1	-6826
FUNDC1	-4734
MAP1LC3B	-2392
PGAM5	514
SRC	2567

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ATG12	-9158
CSNK2A2	-8671
MAP1LC3A	-8317
ULK1	-7767
ATG5	-7494
CSNK2B	-7151
CSNK2A1	-6826
FUNDC1	-4734
MAP1LC3B	-2392
PGAM5	514
SRC	2567

---

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

	1077
set	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
setSize	113
pANOVA	1.39e-22
s.dist	-0.532
p.adjustANOVA	5.37e-21

Top enriched genes

Top 20 genes

GeneID	Gene Rank
COX7A2L	-8906
ATP5F1E	-8877
NDUFA3	-8846
ATP5ME	-8728
ATP5MG	-8231
ETFDH	-8196
NDUFA13	-8067
UQCRB	-8044
NDUFB1	-8003
NDUFS5	-7980
ACAD9	-7909
NDUFA1	-7698
COX19	-7513
ATP5MF	-7330
NDUFA5	-7269
ATP5PD	-7238
NDUFB6	-7222
UQCRH	-7220
ECSIT	-7191
SDHD	-7137

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
COX7A2L	-8906
ATP5F1E	-8877
NDUFA3	-8846
ATP5ME	-8728
ATP5MG	-8231
ETFDH	-8196
NDUFA13	-8067
UQCRB	-8044
NDUFB1	-8003
NDUFS5	-7980
ACAD9	-7909
NDUFA1	-7698
COX19	-7513
ATP5MF	-7330
NDUFA5	-7269
ATP5PD	-7238
NDUFB6	-7222
UQCRH	-7220
ECSIT	-7191
SDHD	-7137
NDUFAF3	-7123
NDUFB7	-7112
NDUFS6	-7098
NDUFAF7	-7081
NDUFB3	-7055
COX16	-7034
NDUFA2	-6890
COX4I1	-6885
SCO1	-6863
COX11	-6850
NUBPL	-6772
COX7C	-6734
NDUFAF2	-6732
SLC25A27	-6590
COX6B1	-6548
SURF1	-6412
SDHC	-6395
CYCS	-6361
UQCR11	-6321
NDUFB11	-6297
ATP5PB	-6099
LRPPRC	-6094
COX18	-6055
NDUFS4	-6030
TMEM126B	-6018
TACO1	-6011
ATP5PO	-5955
NDUFV1	-5939
ETFB	-5922
NDUFAF4	-5911
NDUFB4	-5862
UQCR10	-5858
NDUFAB1	-5813
SDHB	-5717
COX5A	-5712
ATP5MC3	-5706
COX5B	-5661
ATP5MC1	-5616
ATP5PF	-5598
NDUFA9	-5531
NDUFS8	-5514
COX7B	-5472
NDUFB2	-5440
ATP5F1D	-5435
UQCRQ	-5274
NDUFB8	-5236
UQCRFS1	-5204
NDUFS3	-5200
NDUFA6	-5145
CYC1	-5107
TIMMDC1	-5100
NDUFA8	-5082
NDUFA12	-5058
UQCRC2	-5018
NDUFC2	-5013
ATP5MC2	-4894
SDHA	-4816
NDUFB5	-4794
NDUFA11	-4742
NDUFS7	-4717
NDUFA10	-4614
ATP5F1A	-4610
NDUFB10	-4599
NDUFV2	-4583
COX8A	-4434
NDUFV3	-4416
COX6C	-4251
ETFA	-4099
NDUFA4	-4050
NDUFAF5	-3963
ATP5F1B	-3894
NDUFC1	-3785
ATP5F1C	-3741
TRAP1	-3690
UQCRC1	-3562
COX14	-3557
TMEM186	-3467
COA1	-3444
NDUFS1	-3379
SLC25A14	-3176
NDUFS2	-3012
COQ10A	-2975
SCO2	-2688
NDUFB9	-2423
DMAC2L	-2145
NDUFAF6	-1592
NDUFA7	-1474
UCP2	-701
COX6A1	-390
COQ10B	303
COX20	1152
NDUFAF1	1210
UCP3	1325

---

Mitochondrial translation

Mitochondrial translation

	704
set	Mitochondrial translation
setSize	94
pANOVA	5.59e-19
s.dist	-0.531
p.adjustANOVA	1.82e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MTRF1L	-7895
MRPL28	-7802
CHCHD1	-7733
TUFM	-7564
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MTRF1L	-7895
MRPL28	-7802
CHCHD1	-7733
TUFM	-7564
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343
MRPL27	-7283
MRPL12	-7164
MRPS27	-7037
GADD45GIP1	-7031
MRPL16	-6987
MRPL18	-6934
MRPL58	-6870
MRPL4	-6846
MRPL52	-6792
MRPL57	-6665
MRPL46	-6656
MRPS21	-6507
MRPL42	-6451
MRPL1	-6405
MRPS25	-6310
MRPL11	-6283
MRPS14	-6190
MRPS15	-6153
DAP3	-6131
MRRF	-6096
MRPS9	-5883
MRPL41	-5867
MRPL21	-5747
MRPL24	-5724
MTIF3	-5720
MRPL45	-5609
MTIF2	-5550
PTCD3	-5547
MRPS16	-5488
MRPL33	-5487
MRPL38	-5462
MRPL37	-5453
MRPL15	-5432
MRPL44	-5420
MRPS26	-5293
MRPS18B	-5089
GFM1	-5050
MTFMT	-4965
MRPL17	-4871
MRPL2	-4827
MRPL39	-4731
OXA1L	-4723
MRPS22	-4603
MRPS11	-4578
MRPL53	-4339
MRPS18A	-4326
MRPS35	-4276
AURKAIP1	-4245
MRPL35	-4049
MRPS33	-4027
MRPL20	-3969
MRPS10	-3918
GFM2	-3914
MRPL55	-3816
TSFM	-3735
MRPS12	-3716
MRPS7	-3161
MRPS24	-3150
MRPL49	-3106
MRPL10	-3084
MRPL36	-2733
MRPS23	-2539
ERAL1	-2519
MRPS28	-2436
MRPL40	-2188
MRPL43	-2122
MRPL50	-2063
MRPL14	-1341
MRPS18C	-1155
MRPL23	-454
MRPL3	494
MRPS31	1430
MRPS6	4951

---

Mitochondrial translation termination

Mitochondrial translation termination

	707
set	Mitochondrial translation termination
setSize	88
pANOVA	8.14e-18
s.dist	-0.53
p.adjustANOVA	2.53e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MTRF1L	-7895
MRPL28	-7802
CHCHD1	-7733
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MTRF1L	-7895
MRPL28	-7802
CHCHD1	-7733
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343
MRPL27	-7283
MRPL12	-7164
MRPS27	-7037
GADD45GIP1	-7031
MRPL16	-6987
MRPL18	-6934
MRPL58	-6870
MRPL4	-6846
MRPL52	-6792
MRPL57	-6665
MRPL46	-6656
MRPS21	-6507
MRPL42	-6451
MRPL1	-6405
MRPS25	-6310
MRPL11	-6283
MRPS14	-6190
MRPS15	-6153
DAP3	-6131
MRRF	-6096
MRPS9	-5883
MRPL41	-5867
MRPL21	-5747
MRPL24	-5724
MRPL45	-5609
PTCD3	-5547
MRPS16	-5488
MRPL33	-5487
MRPL38	-5462
MRPL37	-5453
MRPL15	-5432
MRPL44	-5420
MRPS26	-5293
MRPS18B	-5089
MRPL17	-4871
MRPL2	-4827
MRPL39	-4731
OXA1L	-4723
MRPS22	-4603
MRPS11	-4578
MRPL53	-4339
MRPS18A	-4326
MRPS35	-4276
AURKAIP1	-4245
MRPL35	-4049
MRPS33	-4027
MRPL20	-3969
MRPS10	-3918
GFM2	-3914
MRPL55	-3816
MRPS12	-3716
MRPS7	-3161
MRPS24	-3150
MRPL49	-3106
MRPL10	-3084
MRPL36	-2733
MRPS23	-2539
ERAL1	-2519
MRPS28	-2436
MRPL40	-2188
MRPL43	-2122
MRPL50	-2063
MRPL14	-1341
MRPS18C	-1155
MRPL23	-454
MRPL3	494
MRPS31	1430
MRPS6	4951

---

Mitochondrial translation elongation

Mitochondrial translation elongation

	705
set	Mitochondrial translation elongation
setSize	88
pANOVA	1.1e-17
s.dist	-0.528
p.adjustANOVA	3.36e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MRPL28	-7802
CHCHD1	-7733
TUFM	-7564
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MRPL28	-7802
CHCHD1	-7733
TUFM	-7564
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343
MRPL27	-7283
MRPL12	-7164
MRPS27	-7037
GADD45GIP1	-7031
MRPL16	-6987
MRPL18	-6934
MRPL58	-6870
MRPL4	-6846
MRPL52	-6792
MRPL57	-6665
MRPL46	-6656
MRPS21	-6507
MRPL42	-6451
MRPL1	-6405
MRPS25	-6310
MRPL11	-6283
MRPS14	-6190
MRPS15	-6153
DAP3	-6131
MRPS9	-5883
MRPL41	-5867
MRPL21	-5747
MRPL24	-5724
MRPL45	-5609
PTCD3	-5547
MRPS16	-5488
MRPL33	-5487
MRPL38	-5462
MRPL37	-5453
MRPL15	-5432
MRPL44	-5420
MRPS26	-5293
MRPS18B	-5089
GFM1	-5050
MRPL17	-4871
MRPL2	-4827
MRPL39	-4731
OXA1L	-4723
MRPS22	-4603
MRPS11	-4578
MRPL53	-4339
MRPS18A	-4326
MRPS35	-4276
AURKAIP1	-4245
MRPL35	-4049
MRPS33	-4027
MRPL20	-3969
MRPS10	-3918
MRPL55	-3816
TSFM	-3735
MRPS12	-3716
MRPS7	-3161
MRPS24	-3150
MRPL49	-3106
MRPL10	-3084
MRPL36	-2733
MRPS23	-2539
ERAL1	-2519
MRPS28	-2436
MRPL40	-2188
MRPL43	-2122
MRPL50	-2063
MRPL14	-1341
MRPS18C	-1155
MRPL23	-454
MRPL3	494
MRPS31	1430
MRPS6	4951

---

Mitochondrial translation initiation

Mitochondrial translation initiation

	706
set	Mitochondrial translation initiation
setSize	88
pANOVA	1.13e-17
s.dist	-0.528
p.adjustANOVA	3.37e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MRPL28	-7802
CHCHD1	-7733
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343
MRPL27	-7283

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MRPL54	-9175
MRPL48	-8950
MRPL22	-8839
MRPS30	-8683
MRPS5	-8542
MRPL34	-8468
MRPS2	-8420
MRPL13	-8240
MRPL9	-8107
MRPS17	-8104
MRPS36	-8062
MRPL28	-7802
CHCHD1	-7733
MRPS34	-7562
MRPL30	-7505
MRPL51	-7503
MRPL19	-7376
MRPL32	-7346
MRPL47	-7343
MRPL27	-7283
MRPL12	-7164
MRPS27	-7037
GADD45GIP1	-7031
MRPL16	-6987
MRPL18	-6934
MRPL58	-6870
MRPL4	-6846
MRPL52	-6792
MRPL57	-6665
MRPL46	-6656
MRPS21	-6507
MRPL42	-6451
MRPL1	-6405
MRPS25	-6310
MRPL11	-6283
MRPS14	-6190
MRPS15	-6153
DAP3	-6131
MRPS9	-5883
MRPL41	-5867
MRPL21	-5747
MRPL24	-5724
MTIF3	-5720
MRPL45	-5609
MTIF2	-5550
PTCD3	-5547
MRPS16	-5488
MRPL33	-5487
MRPL38	-5462
MRPL37	-5453
MRPL15	-5432
MRPL44	-5420
MRPS26	-5293
MRPS18B	-5089
MTFMT	-4965
MRPL17	-4871
MRPL2	-4827
MRPL39	-4731
OXA1L	-4723
MRPS22	-4603
MRPS11	-4578
MRPL53	-4339
MRPS18A	-4326
MRPS35	-4276
AURKAIP1	-4245
MRPL35	-4049
MRPS33	-4027
MRPL20	-3969
MRPS10	-3918
MRPL55	-3816
MRPS12	-3716
MRPS7	-3161
MRPS24	-3150
MRPL49	-3106
MRPL10	-3084
MRPL36	-2733
MRPS23	-2539
ERAL1	-2519
MRPS28	-2436
MRPL40	-2188
MRPL43	-2122
MRPL50	-2063
MRPL14	-1341
MRPS18C	-1155
MRPL23	-454
MRPL3	494
MRPS31	1430
MRPS6	4951

---

Influenza Infection

Influenza Infection

	558
set	Influenza Infection
setSize	154
pANOVA	3.36e-29
s.dist	-0.523
p.adjustANOVA	1.76e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
HSP90AA1	-8943
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
HSP90AA1	-8943
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RANBP2	-8628
RPS3A	-8610
RPL21	-8604
RPL22	-8602
RPL38	-8575
RPL30	-8551
RPS15	-8544
GTF2F1	-8540
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
POLR2F	-8470
RPL36	-8458
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
KPNB1	-8234
RPL37A	-8193
RPL29	-8173
POLR2L	-8103
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
NUP98	-7680
RPL36AL	-7677
RPS9	-7651
SLC25A6	-7550
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
RPS4X	-7375
RPS7	-7364
GTF2F2	-7325
RPL10A	-7319
XPO1	-7296
RPL28	-7270
RPL18	-7257
RPS28	-7167
RPS27A	-7158
RPS2	-7146
RPS13	-7092
NUP54	-7060
NUP58	-6798
NUP160	-6761
RPS19	-6727
RPL17	-6676
RPS14	-6574
HSPA1A	-6509
SEC13	-6317
NUP37	-6292
RPS5	-6187
RPLP1	-6159
RPL27A	-5778
NUP133	-5771
NUP153	-5691
NUP50	-5632
RPL36A	-5540
NUP210	-5396
POLR2I	-5309
POLR2B	-5288
IPO5	-5262
ISG15	-5246
NUP188	-5218
NUP42	-5201
PARP1	-5170
NUP205	-5042
RPS3	-4984
RPS18	-4906
POLR2A	-4758
CLTA	-4620
RPL23A	-4282
NUP93	-4260
CALR	-3922
RAE1	-3893
RAN	-3759
POLR2C	-3742
GRSF1	-3549
RPS27L	-3238
RPL12	-3022
CLTC	-3017
NUP62	-2956
DNAJC3	-2943
POLR2J	-2719
TPR	-2493
KPNA5	-2443
RPL14	-2377
POM121C	-2353
RPL3L	-2329
CANX	-2175
KPNA1	-1902
KPNA3	-1784
EIF2AK2	-1265
KPNA4	-1222
POM121	-863
NUP155	-830
POLR2K	-326
POLR2E	-285
NUP107	-257
NUP35	-211
RPLP0	-196
RPL39L	-143
POLR2G	121
RPS26	577
RPL22L1	602
NUP88	790
NUP214	985
TGFB1	1202
SEH1L	1613
KPNA2	1909
RPL26L1	2574
AAAS	2639
POLR2D	2746
RPL3	3020
PABPN1	3039
CPSF4	4237
NUP43	4730
POLR2H	5035
NUP85	5357
NDC1	6027

---

Formation of Fibrin Clot (Clotting Cascade)

Formation of Fibrin Clot (Clotting Cascade)

	408
set	Formation of Fibrin Clot (Clotting Cascade)
setSize	20
pANOVA	5.36e-05
s.dist	0.522
p.adjustANOVA	0.000394

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TFPI	7103
F13A1	6621
SERPINE2	6504
A2M	6271
PF4	6150
F2R	5807
F5	5478
F3	5461
F10	5355
PRCP	5033
GP1BB	4968
THBD	4047
PROS1	3322
VWF	3201
PROCR	3157
SERPINA5	2655
SERPING1	1779
F8	-4842
KLKB1	-5366
C1QBP	-6427

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TFPI	7103
F13A1	6621
SERPINE2	6504
A2M	6271
PF4	6150
F2R	5807
F5	5478
F3	5461
F10	5355
PRCP	5033
GP1BB	4968
THBD	4047
PROS1	3322
VWF	3201
PROCR	3157
SERPINA5	2655
SERPING1	1779
F8	-4842
KLKB1	-5366
C1QBP	-6427

---

Branched-chain amino acid catabolism

Branched-chain amino acid catabolism

	123
set	Branched-chain amino acid catabolism
setSize	21
pANOVA	3.89e-05
s.dist	-0.519
p.adjustANOVA	0.000295

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BCKDHB	-8636
PPM1K	-8064
ACAT1	-7523
HIBCH	-7345
IVD	-7156
BCAT2	-6384
HIBADH	-6289
DBT	-6233
MCCC1	-5914
ALDH6A1	-5760
DLD	-5637
MCCC2	-5416
HSD17B10	-5319
ACAD8	-5066
ECHS1	-4997
BCKDHA	-4992
BCKDK	-4893
ACADSB	-4135
AUH	-1884
SLC25A44	-1198

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BCKDHB	-8636
PPM1K	-8064
ACAT1	-7523
HIBCH	-7345
IVD	-7156
BCAT2	-6384
HIBADH	-6289
DBT	-6233
MCCC1	-5914
ALDH6A1	-5760
DLD	-5637
MCCC2	-5416
HSD17B10	-5319
ACAD8	-5066
ECHS1	-4997
BCKDHA	-4992
BCKDK	-4893
ACADSB	-4135
AUH	-1884
SLC25A44	-1198
BCAT1	2281

---

Translation of Replicase and Assembly of the Replication Transcription Complex_9679504

Translation of Replicase and Assembly of the Replication Transcription Complex_9679504

	1370
set	Translation of Replicase and Assembly of the Replication Transcription Complex_9679504
setSize	12
pANOVA	0.00196
s.dist	-0.516
p.adjustANOVA	0.00834

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PIK3C3	-8581
CHMP3	-8379
PIK3R4	-7915
CHMP2B	-6818
CHMP7	-6760
CHMP2A	-6492
CHMP4B	-5674
UVRAG	-5296
CHMP6	-3052
MAP1LC3B	-2392
BECN1	-1741
CHMP4A	120

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PIK3C3	-8581
CHMP3	-8379
PIK3R4	-7915
CHMP2B	-6818
CHMP7	-6760
CHMP2A	-6492
CHMP4B	-5674
UVRAG	-5296
CHMP6	-3052
MAP1LC3B	-2392
BECN1	-1741
CHMP4A	120

---

Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

	114
set	Beta-catenin phosphorylation cascade
setSize	17
pANOVA	0.000242
s.dist	-0.514
p.adjustANOVA	0.00146

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AXIN1	-9179
AMER1	-8922
FRAT2	-8670
PPP2R5C	-8460
APC	-7499
CSNK1A1	-6329
PPP2CA	-6239
PPP2R5D	-6188
FRAT1	-5993
PPP2R5E	-5836
PPP2R5B	-5648
PPP2CB	-4090
GSK3B	-3239
CTNNB1	-2957
PPP2R5A	-2472
PPP2R1A	-1738
PPP2R1B	4557

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AXIN1	-9179
AMER1	-8922
FRAT2	-8670
PPP2R5C	-8460
APC	-7499
CSNK1A1	-6329
PPP2CA	-6239
PPP2R5D	-6188
FRAT1	-5993
PPP2R5E	-5836
PPP2R5B	-5648
PPP2CB	-4090
GSK3B	-3239
CTNNB1	-2957
PPP2R5A	-2472
PPP2R1A	-1738
PPP2R1B	4557

---

Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs

	1051
set	Regulation of expression of SLITs and ROBOs
setSize	162
pANOVA	1.86e-29
s.dist	-0.513
p.adjustANOVA	1.01e-27

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
MAGOH	-8779
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL9	-9193
RPSA	-9069
RPL8	-9045
RPS27	-9023
RPL39	-9019
RPL10	-8958
RPS21	-8956
RPL35	-8896
RPS29	-8889
RPL5	-8844
RPL19	-8835
RPS23	-8794
MAGOH	-8779
FAU	-8778
RPL37	-8774
RPL13	-8760
RPS16	-8752
RPS15A	-8723
RPL26	-8660
RPS24	-8637
RPS3A	-8610
RPL21	-8604
RPL22	-8602
PSMD9	-8596
RPL38	-8575
RPL30	-8551
RPS15	-8544
RPS6	-8538
RPL18A	-8510
RPL32	-8491
RPL7A	-8488
RPS10	-8476
RPL36	-8458
UPF3B	-8403
RPL35A	-8364
RPL27	-8329
RPL34	-8283
RPL4	-8279
RPS11	-8273
UPF2	-8225
RPL37A	-8193
RPL29	-8173
RPL11	-8081
RPL24	-8040
UBA52	-8015
RPL15	-7966
RPL31	-7935
RPS20	-7922
RPL7	-7911
RPL41	-7858
RPS25	-7825
RPS17	-7816
RPL13A	-7782
RPS12	-7764
RPL6	-7750
RPL23	-7726
RPL36AL	-7677
RPS9	-7651
CASC3	-7613
RPLP2	-7545
RPS4Y1	-7535
RPS8	-7427
PSMC2	-7403
RPS4X	-7375
RPS7	-7364
RPL10A	-7319
PSMB3	-7282
RPL28	-7270
RPL18	-7257
USP33	-7216
ELOB	-7170
RPS28	-7167
RPS27A	-7158
RPS2	-7146
PSMA3	-7105
RPS13	-7092
PSMB10	-6950
PSMB1	-6768
RPS19	-6727
RPL17	-6676
RPS14	-6574
PSMF1	-6454
PSME3	-6306
RPS5	-6187
RPLP1	-6159
PSMB6	-6137
PSMD3	-5977
UBB	-5814
RPL27A	-5778
RPL36A	-5540
PSMD8	-5400
NCBP1	-5334
PSMA6	-5322
PSMC6	-5268
GSPT1	-5112
PSMC5	-5067
PSMA2	-5031
CUL2	-4996
RPS3	-4984
PSMA7	-4955
RPS18	-4906
UBC	-4857
PSMB7	-4777
SEM1	-4750
PSMA4	-4631
PSMD13	-4372
RPL23A	-4282
PSMA1	-4199
PSMD6	-4060
RBM8A	-3948
PSMD11	-3874
PSMD12	-3731
ELOC	-3489
ETF1	-3370
RNPS1	-3368
HOXA2	-3339
RBX1	-3249
RPS27L	-3238
PSMC4	-3144
PSMD4	-3131
UPF3A	-3033
RPL12	-3022
PSMC3	-2992
PSMB5	-2933
PSMC1	-2895
PSMD7	-2738
EIF4A3	-2560
PSMA5	-2419
RPL14	-2377
RPL3L	-2329
GSPT2	-1860
PSME2	-1779
PSME1	-1715
LDB1	-1450
PSME4	-1447
EIF4G1	-1413
ZSWIM8	-1358
PSMD2	-768
PSMD14	-686
PSMB2	-661
ROBO1	-547
PABPC1	-423
PSMD1	-351
RPLP0	-196
RPL39L	-143
PSMB4	-124
LHX4	38
DAG1	168
PSMD10	323
RPS26	577
RPL22L1	602
ROBO2	1984
PSMB8	2089
NCBP2	2415
RPL26L1	2574
RPL3	3020
ROBO3	3477
COL4A5	3912
PSMD5	4392
PSMB9	4445
MAGOHB	5294
SLIT2	5948

---

Laminin interactions

Laminin interactions

	626
set	Laminin interactions
setSize	30
pANOVA	1.54e-06
s.dist	0.507
p.adjustANOVA	1.94e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LAMA5	7035
NID1	6988
LAMA3	6917
COL18A1	6872
LAMB1	6787
ITGA3	6774
COL4A1	6492
HSPG2	6439
COL4A2	6432
ITGB4	6414
LAMA2	5859
ITGA1	4864
COL4A6	4606
ITGB1	4290
COL4A5	3912
ITGA6	3776
LAMA4	3639
LAMC1	3149
COL4A4	2640
ITGA7	2519

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LAMA5	7035
NID1	6988
LAMA3	6917
COL18A1	6872
LAMB1	6787
ITGA3	6774
COL4A1	6492
HSPG2	6439
COL4A2	6432
ITGB4	6414
LAMA2	5859
ITGA1	4864
COL4A6	4606
ITGB1	4290
COL4A5	3912
ITGA6	3776
LAMA4	3639
LAMC1	3149
COL4A4	2640
ITGA7	2519
NID2	2251
COL7A1	967
COL4A3	892
LAMC2	582
LAMB2	563
LAMA1	-56
ITGA2	-233
ITGAV	-743
LAMC3	-5840
LAMB3	-9095

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               cachem_1.0.8            zlibbioc_1.48.0        
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] yaml_2.3.8              rstudioapi_0.15.0       abind_1.4-5            
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report