date generated: 2024-03-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
5_8S_rRNA -0.7235362
7SK 0.0792128
A1BG -0.8697311
A1BG.AS1 0.2565051
A2M 1.2525086
A2M.AS1 0.8703520

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 2612
num_genes_in_profile 16514
duplicated_genes_present 0
num_profile_genes_in_sets 8299
num_profile_genes_not_in_sets 8215

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt
Gene set metrics
Gene sets metrics
num_genesets 2612
num_genesets_excluded 1149
num_genesets_included 1463

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
Cohesin Loading onto Chromatin 10 1.15e-05 -0.801 1.07e-04
Formation of the ternary complex, and subsequently, the 43S complex 51 7.71e-22 -0.777 2.82e-20
Formation of a pool of free 40S subunits 100 1.03e-37 -0.742 2.16e-35
SARS-CoV-1 modulates host translation machinery 36 2.55e-14 -0.733 6.92e-13
Ribosomal scanning and start codon recognition 58 8.19e-22 -0.728 2.92e-20
Viral mRNA Translation 88 5.17e-32 -0.725 4.45e-30
Peptide chain elongation 88 1.09e-31 -0.721 8.00e-30
GTP hydrolysis and joining of the 60S ribosomal subunit 111 2.30e-39 -0.720 1.12e-36
Translation initiation complex formation 58 3.70e-21 -0.716 1.26e-19
Selenocysteine synthesis 92 2.02e-32 -0.714 1.97e-30
L13a-mediated translational silencing of Ceruloplasmin expression 110 2.41e-38 -0.713 5.89e-36
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.17e-21 -0.711 1.10e-19
Eukaryotic Translation Termination 92 4.28e-32 -0.710 3.92e-30
Eukaryotic Translation Elongation 93 8.51e-32 -0.703 6.56e-30
Establishment of Sister Chromatid Cohesion 10 1.23e-04 -0.701 8.41e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.21e-31 -0.695 1.54e-29
Cap-dependent Translation Initiation 118 2.18e-38 -0.689 5.89e-36
Eukaryotic Translation Initiation 118 2.18e-38 -0.689 5.89e-36
PINK1-PRKN Mediated Mitophagy 21 7.32e-08 -0.678 1.12e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.41e-31 -0.669 3.44e-29
Expression and translocation of olfactory receptors 25 1.03e-08 0.661 1.81e-07
SARS-CoV-2 modulates host translation machinery 49 3.30e-15 -0.650 9.10e-14
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.22e-32 -0.644 1.28e-30
Nonsense-Mediated Decay (NMD) 114 1.22e-32 -0.644 1.28e-30
Selenoamino acid metabolism 114 8.23e-32 -0.636 6.56e-30
SRP-dependent cotranslational protein targeting to membrane 111 2.59e-30 -0.628 1.58e-28
Mitophagy 28 1.50e-08 -0.618 2.53e-07
Common Pathway of Fibrin Clot Formation 11 4.86e-04 0.607 2.66e-03
Formation of ATP by chemiosmotic coupling 16 3.99e-05 -0.593 3.01e-04
Regulation of FOXO transcriptional activity by acetylation 10 1.17e-03 -0.593 5.58e-03
Olfactory Signaling Pathway 29 3.34e-08 0.592 5.26e-07
Influenza Viral RNA Transcription and Replication 135 4.32e-30 -0.568 2.53e-28
Cellular response to starvation 148 2.33e-31 -0.554 1.55e-29
Translation 292 1.17e-59 -0.553 8.54e-57
Cristae formation 29 4.03e-07 -0.544 5.61e-06
Complex I biogenesis 51 2.08e-11 -0.542 4.68e-10
Respiratory electron transport 93 3.66e-19 -0.537 1.22e-17
Receptor Mediated Mitophagy 11 2.12e-03 -0.535 8.88e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 1.39e-22 -0.532 5.37e-21
Mitochondrial translation 94 5.59e-19 -0.531 1.82e-17
Mitochondrial translation termination 88 8.14e-18 -0.530 2.53e-16
Mitochondrial translation elongation 88 1.10e-17 -0.528 3.36e-16
Mitochondrial translation initiation 88 1.13e-17 -0.528 3.37e-16
Influenza Infection 154 3.36e-29 -0.523 1.76e-27
Formation of Fibrin Clot (Clotting Cascade) 20 5.36e-05 0.522 3.94e-04
Branched-chain amino acid catabolism 21 3.89e-05 -0.519 2.95e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.96e-03 -0.516 8.34e-03
Beta-catenin phosphorylation cascade 17 2.42e-04 -0.514 1.46e-03
Regulation of expression of SLITs and ROBOs 162 1.86e-29 -0.513 1.01e-27
Laminin interactions 30 1.54e-06 0.507 1.94e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Cohesin Loading onto Chromatin 10 1.15e-05 -0.801000 1.07e-04
Formation of the ternary complex, and subsequently, the 43S complex 51 7.71e-22 -0.777000 2.82e-20
Formation of a pool of free 40S subunits 100 1.03e-37 -0.742000 2.16e-35
SARS-CoV-1 modulates host translation machinery 36 2.55e-14 -0.733000 6.92e-13
Ribosomal scanning and start codon recognition 58 8.19e-22 -0.728000 2.92e-20
Viral mRNA Translation 88 5.17e-32 -0.725000 4.45e-30
Peptide chain elongation 88 1.09e-31 -0.721000 8.00e-30
GTP hydrolysis and joining of the 60S ribosomal subunit 111 2.30e-39 -0.720000 1.12e-36
Translation initiation complex formation 58 3.70e-21 -0.716000 1.26e-19
Selenocysteine synthesis 92 2.02e-32 -0.714000 1.97e-30
L13a-mediated translational silencing of Ceruloplasmin expression 110 2.41e-38 -0.713000 5.89e-36
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 3.17e-21 -0.711000 1.10e-19
Eukaryotic Translation Termination 92 4.28e-32 -0.710000 3.92e-30
Eukaryotic Translation Elongation 93 8.51e-32 -0.703000 6.56e-30
Establishment of Sister Chromatid Cohesion 10 1.23e-04 -0.701000 8.41e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.21e-31 -0.695000 1.54e-29
Cap-dependent Translation Initiation 118 2.18e-38 -0.689000 5.89e-36
Eukaryotic Translation Initiation 118 2.18e-38 -0.689000 5.89e-36
PINK1-PRKN Mediated Mitophagy 21 7.32e-08 -0.678000 1.12e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.41e-31 -0.669000 3.44e-29
Expression and translocation of olfactory receptors 25 1.03e-08 0.661000 1.81e-07
SARS-CoV-2 modulates host translation machinery 49 3.30e-15 -0.650000 9.10e-14
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.22e-32 -0.644000 1.28e-30
Nonsense-Mediated Decay (NMD) 114 1.22e-32 -0.644000 1.28e-30
Selenoamino acid metabolism 114 8.23e-32 -0.636000 6.56e-30
SRP-dependent cotranslational protein targeting to membrane 111 2.59e-30 -0.628000 1.58e-28
Mitophagy 28 1.50e-08 -0.618000 2.53e-07
Common Pathway of Fibrin Clot Formation 11 4.86e-04 0.607000 2.66e-03
Formation of ATP by chemiosmotic coupling 16 3.99e-05 -0.593000 3.01e-04
Regulation of FOXO transcriptional activity by acetylation 10 1.17e-03 -0.593000 5.58e-03
Olfactory Signaling Pathway 29 3.34e-08 0.592000 5.26e-07
Influenza Viral RNA Transcription and Replication 135 4.32e-30 -0.568000 2.53e-28
Cellular response to starvation 148 2.33e-31 -0.554000 1.55e-29
Translation 292 1.17e-59 -0.553000 8.54e-57
Cristae formation 29 4.03e-07 -0.544000 5.61e-06
Complex I biogenesis 51 2.08e-11 -0.542000 4.68e-10
Respiratory electron transport 93 3.66e-19 -0.537000 1.22e-17
Receptor Mediated Mitophagy 11 2.12e-03 -0.535000 8.88e-03
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 113 1.39e-22 -0.532000 5.37e-21
Mitochondrial translation 94 5.59e-19 -0.531000 1.82e-17
Mitochondrial translation termination 88 8.14e-18 -0.530000 2.53e-16
Mitochondrial translation elongation 88 1.10e-17 -0.528000 3.36e-16
Mitochondrial translation initiation 88 1.13e-17 -0.528000 3.37e-16
Influenza Infection 154 3.36e-29 -0.523000 1.76e-27
Formation of Fibrin Clot (Clotting Cascade) 20 5.36e-05 0.522000 3.94e-04
Branched-chain amino acid catabolism 21 3.89e-05 -0.519000 2.95e-04
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504 12 1.96e-03 -0.516000 8.34e-03
Beta-catenin phosphorylation cascade 17 2.42e-04 -0.514000 1.46e-03
Regulation of expression of SLITs and ROBOs 162 1.86e-29 -0.513000 1.01e-27
Laminin interactions 30 1.54e-06 0.507000 1.94e-05
APC truncation mutants have impaired AXIN binding 14 1.27e-03 -0.497000 5.82e-03
AXIN missense mutants destabilize the destruction complex 14 1.27e-03 -0.497000 5.82e-03
Signaling by AMER1 mutants 14 1.27e-03 -0.497000 5.82e-03
Signaling by APC mutants 14 1.27e-03 -0.497000 5.82e-03
Signaling by AXIN mutants 14 1.27e-03 -0.497000 5.82e-03
Truncations of AMER1 destabilize the destruction complex 14 1.27e-03 -0.497000 5.82e-03
cGMP effects 14 1.81e-03 0.481000 8.01e-03
CTNNB1 S33 mutants aren’t phosphorylated 15 1.28e-03 -0.480000 5.82e-03
CTNNB1 S37 mutants aren’t phosphorylated 15 1.28e-03 -0.480000 5.82e-03
CTNNB1 S45 mutants aren’t phosphorylated 15 1.28e-03 -0.480000 5.82e-03
CTNNB1 T41 mutants aren’t phosphorylated 15 1.28e-03 -0.480000 5.82e-03
Signaling by CTNNB1 phospho-site mutants 15 1.28e-03 -0.480000 5.82e-03
Signaling by GSK3beta mutants 15 1.28e-03 -0.480000 5.82e-03
The citric acid (TCA) cycle and respiratory electron transport 160 1.68e-25 -0.478000 7.01e-24
Mitochondrial Fatty Acid Beta-Oxidation 34 1.66e-06 -0.475000 2.04e-05
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676 13 3.10e-03 -0.474000 1.25e-02
Mitotic Telophase/Cytokinesis 13 3.22e-03 -0.472000 1.29e-02
Eicosanoid ligand-binding receptors 13 3.37e-03 0.470000 1.33e-02
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.80e-27 -0.469000 7.96e-26
Attenuation phase 23 1.03e-04 -0.468000 7.13e-04
HIV elongation arrest and recovery 32 4.99e-06 -0.466000 5.25e-05
Pausing and recovery of HIV elongation 32 4.99e-06 -0.466000 5.25e-05
TICAM1,TRAF6-dependent induction of TAK1 complex 11 7.73e-03 -0.464000 2.70e-02
Alpha-protein kinase 1 signaling pathway 11 7.79e-03 -0.463000 2.71e-02
rRNA processing in the nucleus and cytosol 190 3.19e-28 -0.463000 1.50e-26
NF-kB is activated and signals survival 13 3.83e-03 -0.463000 1.49e-02
Cytosolic tRNA aminoacylation 24 9.07e-05 -0.462000 6.35e-04
FOXO-mediated transcription of cell death genes 15 2.03e-03 -0.460000 8.54e-03
rRNA processing 200 7.53e-29 -0.457000 3.67e-27
Mitochondrial protein import 63 4.69e-10 -0.454000 9.40e-09
E3 ubiquitin ligases ubiquitinate target proteins 44 2.04e-07 -0.453000 2.95e-06
Regulation of BACH1 activity 11 9.45e-03 -0.452000 3.10e-02
mRNA Splicing 210 3.90e-29 -0.448000 1.97e-27
mRNA Splicing - Major Pathway 202 8.84e-28 -0.446000 4.04e-26
Citric acid cycle (TCA cycle) 22 3.01e-04 -0.445000 1.78e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 29 3.74e-05 -0.442000 2.86e-04
mRNA Splicing - Minor Pathway 50 8.36e-08 -0.438000 1.25e-06
Pausing and recovery of Tat-mediated HIV elongation 30 3.50e-05 -0.437000 2.74e-04
Tat-mediated HIV elongation arrest and recovery 30 3.50e-05 -0.437000 2.74e-04
Suppression of phagosomal maturation 13 6.66e-03 -0.435000 2.36e-02
Peroxisomal protein import 56 1.88e-08 -0.434000 3.12e-07
Formation of RNA Pol II elongation complex 56 2.00e-08 -0.434000 3.26e-07
RNA Polymerase II Transcription Elongation 56 2.00e-08 -0.434000 3.26e-07
Defective B3GALTL causes PpS 35 1.10e-05 0.429000 1.04e-04
tRNA Aminoacylation 42 1.79e-06 -0.426000 2.15e-05
Glyoxylate metabolism and glycine degradation 24 3.06e-04 -0.426000 1.79e-03
O-glycosylation of TSR domain-containing proteins 36 1.10e-05 0.423000 1.04e-04
Protein ubiquitination 63 6.81e-09 -0.422000 1.21e-07
Mitochondrial iron-sulfur cluster biogenesis 13 9.22e-03 -0.417000 3.06e-02
ERBB2 Activates PTK6 Signaling 11 1.66e-02 0.417000 4.81e-02
Crosslinking of collagen fibrils 18 2.39e-03 0.413000 9.98e-03
Adrenaline,noradrenaline inhibits insulin secretion 22 7.90e-04 0.413000 3.98e-03
Chaperone Mediated Autophagy 20 1.41e-03 -0.412000 6.34e-03
Abortive elongation of HIV-1 transcript in the absence of Tat 23 6.83e-04 -0.409000 3.52e-03
Protein localization 154 2.14e-18 -0.409000 6.80e-17
mRNA decay by 5’ to 3’ exoribonuclease 15 6.18e-03 -0.408000 2.23e-02
IRAK2 mediated activation of TAK1 complex 10 2.60e-02 -0.407000 6.95e-02
APC-Cdc20 mediated degradation of Nek2A 23 7.79e-04 -0.405000 3.95e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids 10 2.68e-02 -0.405000 7.06e-02
Formation of HIV elongation complex in the absence of HIV Tat 44 3.60e-06 -0.404000 4.06e-05
Translesion synthesis by POLK 17 4.11e-03 -0.402000 1.57e-02
Translesion synthesis by REV1 16 6.08e-03 -0.396000 2.21e-02
Signaling by ROBO receptors 201 3.69e-22 -0.396000 1.38e-20
RORA activates gene expression 18 3.63e-03 -0.396000 1.42e-02
Processing of Capped Intron-Containing Pre-mRNA 278 9.22e-30 -0.395000 5.19e-28
Late endosomal microautophagy 31 1.49e-04 -0.394000 9.76e-04
Folding of actin by CCT/TriC 10 3.17e-02 -0.392000 8.01e-02
Membrane binding and targetting of GAG proteins 14 1.11e-02 -0.392000 3.53e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.11e-02 -0.392000 3.53e-02
HSF1 activation 26 5.69e-04 -0.390000 2.99e-03
Prolactin receptor signaling 10 3.30e-02 -0.389000 8.22e-02
Mitochondrial tRNA aminoacylation 21 2.02e-03 -0.389000 8.52e-03
VLDLR internalisation and degradation 15 9.34e-03 -0.388000 3.09e-02
Translesion synthesis by POLI 17 5.82e-03 -0.386000 2.14e-02
RNA Polymerase II Pre-transcription Events 77 5.37e-09 -0.385000 9.71e-08
mTORC1-mediated signalling 24 1.16e-03 -0.383000 5.52e-03
Processing of SMDT1 15 1.06e-02 -0.381000 3.40e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects 19 4.16e-03 -0.380000 1.59e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 2.10e-05 -0.379000 1.73e-04
HIV Transcription Elongation 42 2.10e-05 -0.379000 1.73e-04
Tat-mediated elongation of the HIV-1 transcript 42 2.10e-05 -0.379000 1.73e-04
Metabolism of RNA 695 2.08e-64 -0.378000 3.04e-61
Endosomal Sorting Complex Required For Transport (ESCRT) 30 3.55e-04 -0.377000 2.02e-03
EPHA-mediated growth cone collapse 23 1.83e-03 0.375000 8.03e-03
SUMOylation of transcription cofactors 44 1.66e-05 -0.375000 1.43e-04
Cytoprotection by HMOX1 58 1.01e-06 -0.371000 1.35e-05
Methylation 12 2.61e-02 -0.371000 6.96e-02
APC/C:Cdc20 mediated degradation of Cyclin B 22 2.68e-03 -0.370000 1.10e-02
Formation of the Early Elongation Complex 33 2.58e-04 -0.368000 1.54e-03
Formation of the HIV-1 Early Elongation Complex 33 2.58e-04 -0.368000 1.54e-03
Peroxisomal lipid metabolism 25 1.48e-03 -0.367000 6.64e-03
SARS-CoV-1-host interactions 93 1.07e-09 -0.366000 2.08e-08
Metalloprotease DUBs 19 5.83e-03 -0.365000 2.14e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 51 7.42e-06 -0.363000 7.44e-05
Cell-extracellular matrix interactions 18 8.10e-03 0.361000 2.78e-02
Pexophagy 11 3.94e-02 -0.359000 9.53e-02
Signaling by PDGFRA extracellular domain mutants 12 3.18e-02 -0.358000 8.01e-02
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 3.18e-02 -0.358000 8.01e-02
Nitric oxide stimulates guanylate cyclase 18 8.65e-03 0.358000 2.91e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 21 4.71e-03 -0.356000 1.77e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 5.30e-02 -0.353000 1.22e-01
Assembly Of The HIV Virion 16 1.44e-02 -0.353000 4.32e-02
Autodegradation of Cdh1 by Cdh1:APC/C 63 1.27e-06 -0.353000 1.64e-05
Dectin-1 mediated noncanonical NF-kB signaling 58 3.44e-06 -0.352000 3.90e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 52 1.16e-05 -0.352000 1.07e-04
Transcription of the HIV genome 67 6.88e-07 -0.351000 9.32e-06
Interleukin-10 signaling 27 1.62e-03 0.351000 7.17e-03
Inactivation of APC/C via direct inhibition of the APC/C complex 19 8.24e-03 -0.350000 2.79e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 19 8.24e-03 -0.350000 2.79e-02
Metabolism of amino acids and derivatives 315 1.71e-26 -0.349000 7.36e-25
Degradation of the extracellular matrix 113 1.82e-10 0.347000 3.86e-09
Intrinsic Pathway of Fibrin Clot Formation 12 3.76e-02 0.347000 9.20e-02
Defective CFTR causes cystic fibrosis 57 6.33e-06 -0.346000 6.52e-05
Anchoring fibril formation 15 2.06e-02 0.345000 5.80e-02
Degradation of AXIN 53 1.38e-05 -0.345000 1.21e-04
Regulation of Complement cascade 30 1.08e-03 0.345000 5.16e-03
Peptide ligand-binding receptors 77 1.68e-07 0.345000 2.46e-06
NIK–>noncanonical NF-kB signaling 57 6.72e-06 -0.345000 6.87e-05
Elevation of cytosolic Ca2+ levels 13 3.14e-02 0.345000 8.00e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 13 3.16e-02 0.344000 8.00e-02
Defective EXT2 causes exostoses 2 13 3.16e-02 0.344000 8.00e-02
STAT3 nuclear events downstream of ALK signaling 10 5.94e-02 -0.344000 1.32e-01
Voltage gated Potassium channels 19 9.46e-03 0.344000 3.10e-02
Ubiquitin-dependent degradation of Cyclin D 50 2.61e-05 -0.344000 2.08e-04
Degradation of cysteine and homocysteine 14 2.60e-02 -0.344000 6.94e-02
HDMs demethylate histones 21 6.43e-03 -0.344000 2.31e-02
Regulation of Apoptosis 51 2.20e-05 -0.344000 1.80e-04
APC/C:Cdc20 mediated degradation of Securin 64 2.03e-06 -0.343000 2.39e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 1.53e-05 -0.343000 1.33e-04
Regulation of PTEN mRNA translation 11 4.88e-02 -0.343000 1.14e-01
Vpu mediated degradation of CD4 50 2.92e-05 -0.342000 2.31e-04
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 5.00e-02 -0.341000 1.17e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23 4.64e-03 -0.341000 1.74e-02
NCAM1 interactions 32 8.47e-04 0.341000 4.24e-03
SLBP independent Processing of Histone Pre-mRNAs 10 6.24e-02 -0.340000 1.37e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 5.08e-02 -0.340000 1.17e-01
alpha-linolenic acid (ALA) metabolism 11 5.08e-02 -0.340000 1.17e-01
Basigin interactions 22 5.85e-03 0.339000 2.14e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 4.77e-05 -0.339000 3.53e-04
Receptor-type tyrosine-protein phosphatases 13 3.45e-02 0.339000 8.56e-02
Postmitotic nuclear pore complex (NPC) reformation 27 2.46e-03 -0.337000 1.02e-02
Early Phase of HIV Life Cycle 14 3.00e-02 -0.335000 7.77e-02
Association of TriC/CCT with target proteins during biosynthesis 34 7.50e-04 -0.334000 3.82e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 18 1.45e-02 -0.333000 4.32e-02
Diseases associated with O-glycosylation of proteins 54 2.40e-05 0.332000 1.95e-04
HIV Life Cycle 145 5.41e-12 -0.332000 1.34e-10
Vif-mediated degradation of APOBEC3G 52 3.86e-05 -0.330000 2.94e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 69 2.20e-06 -0.330000 2.56e-05
Class A/1 (Rhodopsin-like receptors) 141 1.48e-11 0.329000 3.38e-10
Negative regulation of NOTCH4 signaling 54 2.84e-05 -0.329000 2.26e-04
p75NTR signals via NF-kB 16 2.28e-02 -0.329000 6.25e-02
Macroautophagy 124 2.60e-10 -0.329000 5.35e-09
rRNA processing in the mitochondrion 10 7.28e-02 -0.328000 1.54e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 2.81e-02 -0.327000 7.38e-02
Phase 0 - rapid depolarisation 28 2.76e-03 0.327000 1.13e-02
Activation of Matrix Metalloproteinases 21 9.54e-03 0.327000 3.11e-02
Degradation of beta-catenin by the destruction complex 83 2.83e-07 -0.326000 4.02e-06
Late Phase of HIV Life Cycle 132 1.10e-10 -0.325000 2.41e-09
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 4.20e-05 -0.325000 3.15e-04
SHC-mediated cascade:FGFR4 13 4.40e-02 0.323000 1.04e-01
Dissolution of Fibrin Clot 11 6.53e-02 0.321000 1.43e-01
ABC transporter disorders 69 4.06e-06 -0.321000 4.47e-05
ERBB2 Regulates Cell Motility 13 4.52e-02 0.321000 1.07e-01
Autophagy 139 7.06e-11 -0.320000 1.57e-09
Regulation of PTEN stability and activity 67 5.87e-06 -0.320000 6.13e-05
Smooth Muscle Contraction 36 8.88e-04 0.320000 4.42e-03
Regulation of RUNX2 expression and activity 70 3.86e-06 -0.319000 4.28e-05
Mitochondrial calcium ion transport 22 9.63e-03 -0.319000 3.14e-02
HIV Infection 221 3.85e-16 -0.318000 1.08e-14
Downstream signaling events of B Cell Receptor (BCR) 78 1.24e-06 -0.318000 1.63e-05
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.87e-04 -0.317000 4.83e-03
Assembly of the pre-replicative complex 87 3.23e-07 -0.317000 4.55e-06
Other semaphorin interactions 19 1.69e-02 0.317000 4.86e-02
Hh mutants are degraded by ERAD 53 6.95e-05 -0.316000 4.92e-04
Circadian Clock 66 9.56e-06 -0.315000 9.33e-05
Mitochondrial biogenesis 87 4.26e-07 -0.314000 5.88e-06
Formation of Incision Complex in GG-NER 43 3.75e-04 -0.314000 2.11e-03
Deadenylation-dependent mRNA decay 50 1.27e-04 -0.313000 8.60e-04
Activation of NF-kappaB in B cells 65 1.29e-05 -0.313000 1.15e-04
Translesion Synthesis by POLH 18 2.16e-02 -0.313000 6.04e-02
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 1.63e-04 -0.311000 1.05e-03
p53-Independent DNA Damage Response 49 1.63e-04 -0.311000 1.05e-03
p53-Independent G1/S DNA damage checkpoint 49 1.63e-04 -0.311000 1.05e-03
Molecules associated with elastic fibres 33 1.98e-03 0.311000 8.40e-03
Downstream TCR signaling 80 1.50e-06 -0.311000 1.93e-05
Collagen degradation 55 6.96e-05 0.310000 4.92e-04
Josephin domain DUBs 10 9.05e-02 -0.309000 1.82e-01
Complement cascade 34 1.82e-03 0.309000 8.01e-03
Amino acids regulate mTORC1 48 2.14e-04 -0.309000 1.32e-03
Sema4D induced cell migration and growth-cone collapse 20 1.68e-02 0.309000 4.86e-02
SARS-CoV-1 Infection 135 5.94e-10 -0.309000 1.18e-08
Autodegradation of the E3 ubiquitin ligase COP1 49 1.86e-04 -0.309000 1.17e-03
GLI3 is processed to GLI3R by the proteasome 57 5.76e-05 -0.308000 4.21e-04
Budding and maturation of HIV virion 27 5.65e-03 -0.308000 2.08e-02
CDK-mediated phosphorylation and removal of Cdc6 68 1.19e-05 -0.307000 1.09e-04
RHO GTPases activate CIT 18 2.41e-02 0.307000 6.53e-02
mRNA 3’-end processing 57 6.31e-05 -0.306000 4.57e-04
RNA Polymerase II Transcription Termination 66 1.68e-05 -0.306000 1.43e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 68 1.26e-05 -0.306000 1.13e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 68 1.26e-05 -0.306000 1.13e-04
SCF-beta-TrCP mediated degradation of Emi1 52 1.37e-04 -0.306000 9.22e-04
TP53 Regulates Transcription of DNA Repair Genes 61 3.72e-05 -0.305000 2.86e-04
TNFR1-induced NF-kappa-B signaling pathway 32 2.89e-03 -0.304000 1.17e-02
Metabolism of porphyrins 21 1.59e-02 -0.304000 4.68e-02
SARS-CoV-2 modulates autophagy 11 8.10e-02 -0.304000 1.69e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.20e-02 -0.304000 6.09e-02
Elastic fibre formation 40 9.12e-04 0.303000 4.49e-03
Deadenylation of mRNA 22 1.41e-02 -0.302000 4.23e-02
Detoxification of Reactive Oxygen Species 33 2.67e-03 -0.302000 1.10e-02
Heme signaling 44 5.29e-04 -0.302000 2.84e-03
Degradation of GLI2 by the proteasome 57 8.05e-05 -0.302000 5.66e-04
Interactions of Rev with host cellular proteins 37 1.50e-03 -0.302000 6.68e-03
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 44 5.37e-04 -0.302000 2.88e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.02e-05 -0.301000 9.71e-05
RNA Pol II CTD phosphorylation and interaction with CE 27 6.81e-03 -0.301000 2.41e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 6.81e-03 -0.301000 2.41e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 85 1.70e-06 0.300000 2.05e-05
SARS-CoV-2-host interactions 175 8.44e-12 -0.300000 2.06e-10
FGFR2 alternative splicing 24 1.12e-02 -0.299000 3.54e-02
Switching of origins to a post-replicative state 85 2.01e-06 -0.298000 2.39e-05
Signaling by cytosolic FGFR1 fusion mutants 18 2.89e-02 -0.298000 7.51e-02
Uptake and function of anthrax toxins 11 8.77e-02 -0.297000 1.77e-01
Cellular response to chemical stress 183 4.56e-12 -0.297000 1.15e-10
Collagen chain trimerization 41 1.02e-03 0.297000 4.96e-03
Cellular response to hypoxia 72 1.38e-05 -0.296000 1.21e-04
Host Interactions of HIV factors 125 1.12e-08 -0.296000 1.94e-07
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 4.09e-02 -0.295000 9.79e-02
Endogenous sterols 19 2.59e-02 -0.295000 6.94e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 27 7.95e-03 -0.295000 2.74e-02
LGI-ADAM interactions 11 9.31e-02 0.292000 1.86e-01
SUMOylation of RNA binding proteins 47 5.26e-04 -0.292000 2.84e-03
Metabolism of non-coding RNA 53 2.36e-04 -0.292000 1.43e-03
snRNP Assembly 53 2.36e-04 -0.292000 1.43e-03
SUMOylation of chromatin organization proteins 57 1.44e-04 -0.291000 9.60e-04
HSF1-dependent transactivation 33 3.85e-03 -0.291000 1.49e-02
TP53 Regulates Metabolic Genes 81 6.17e-06 -0.291000 6.40e-05
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.19e-02 -0.290000 3.70e-02
FCERI mediated NF-kB activation 79 8.21e-06 -0.290000 8.12e-05
HATs acetylate histones 84 4.33e-06 -0.290000 4.62e-05
Selective autophagy 72 2.16e-05 -0.290000 1.78e-04
Degradation of GLI1 by the proteasome 57 1.68e-04 -0.288000 1.08e-03
Cyclin E associated events during G1/S transition 80 8.58e-06 -0.288000 8.42e-05
Inactivation of CSF3 (G-CSF) signaling 25 1.28e-02 -0.288000 3.89e-02
DNA Double Strand Break Response 45 8.61e-04 -0.287000 4.30e-03
p130Cas linkage to MAPK signaling for integrins 12 8.52e-02 0.287000 1.74e-01
Cellular responses to stress 687 2.12e-37 -0.287000 3.88e-35
HCMV Late Events 60 1.26e-04 -0.286000 8.56e-04
Formation of TC-NER Pre-Incision Complex 53 3.13e-04 -0.286000 1.82e-03
NCAM signaling for neurite out-growth 52 3.60e-04 0.286000 2.04e-03
RHOBTB1 GTPase cycle 23 1.76e-02 -0.286000 5.04e-02
Adenylate cyclase inhibitory pathway 13 7.46e-02 0.286000 1.58e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 15 5.56e-02 -0.285000 1.27e-01
Regulation of signaling by CBL 22 2.06e-02 -0.285000 5.80e-02
CLEC7A (Dectin-1) signaling 95 1.59e-06 -0.285000 1.97e-05
Regulation of TP53 Activity through Acetylation 29 7.93e-03 -0.285000 2.74e-02
Pyruvate metabolism 27 1.06e-02 -0.284000 3.40e-02
mRNA Capping 29 8.10e-03 -0.284000 2.78e-02
Cellular responses to stimuli 694 7.54e-37 -0.283000 1.23e-34
SUMOylation of DNA damage response and repair proteins 77 1.75e-05 -0.283000 1.49e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 3.77e-03 -0.283000 1.47e-02
Post-translational protein phosphorylation 76 2.01e-05 0.283000 1.69e-04
Initial triggering of complement 17 4.36e-02 0.283000 1.04e-01
Diseases of mitotic cell cycle 35 3.89e-03 -0.282000 1.50e-02
Physiological factors 10 1.24e-01 -0.281000 2.32e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 1.06e-01 0.281000 2.07e-01
rRNA modification in the nucleus and cytosol 59 1.95e-04 -0.280000 1.22e-03
Hh mutants abrogate ligand secretion 55 3.28e-04 -0.280000 1.88e-03
Viral Infection Pathways 656 3.27e-34 -0.280000 4.79e-32
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 18 4.01e-02 -0.279000 9.66e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.10e-02 -0.279000 1.35e-01
Formation of the cornified envelope 22 2.33e-02 0.279000 6.36e-02
Keratinization 22 2.33e-02 0.279000 6.36e-02
Deactivation of the beta-catenin transactivating complex 39 2.57e-03 -0.279000 1.07e-02
Regulation of TNFR1 signaling 47 9.43e-04 -0.279000 4.63e-03
FGFR2 ligand binding and activation 10 1.27e-01 0.279000 2.36e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 8.20e-02 -0.279000 1.70e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 5.38e-02 -0.278000 1.23e-01
ER Quality Control Compartment (ERQC) 21 2.74e-02 -0.278000 7.21e-02
Regulation of mRNA stability by proteins that bind AU-rich elements 87 7.83e-06 -0.277000 7.79e-05
Regulation of ornithine decarboxylase (ODC) 48 8.91e-04 -0.277000 4.42e-03
Cross-presentation of soluble exogenous antigens (endosomes) 46 1.18e-03 -0.277000 5.58e-03
APC/C:Cdc20 mediated degradation of mitotic proteins 70 6.50e-05 -0.276000 4.69e-04
S Phase 152 4.31e-09 -0.276000 7.95e-08
Synthesis of bile acids and bile salts 25 1.69e-02 -0.276000 4.86e-02
Potassium Channels 54 4.55e-04 0.276000 2.51e-03
Base-Excision Repair, AP Site Formation 23 2.22e-02 -0.275000 6.13e-02
Transport of Mature Transcript to Cytoplasm 81 1.86e-05 -0.275000 1.57e-04
Degradation of DVL 55 4.17e-04 -0.275000 2.32e-03
Assembly of collagen fibrils and other multimeric structures 57 3.28e-04 0.275000 1.88e-03
Regulation of NPAS4 gene expression 12 9.90e-02 -0.275000 1.96e-01
Metabolism of cofactors 18 4.36e-02 -0.275000 1.04e-01
Retrograde neurotrophin signalling 13 8.65e-02 -0.275000 1.76e-01
Chromatin modifying enzymes 205 1.44e-11 -0.274000 3.33e-10
Chromatin organization 205 1.44e-11 -0.274000 3.33e-10
TBC/RABGAPs 43 1.92e-03 -0.273000 8.24e-03
SCF(Skp2)-mediated degradation of p27/p21 58 3.22e-04 -0.273000 1.86e-03
Phosphorylation of the APC/C 19 3.94e-02 -0.273000 9.54e-02
SHC-mediated cascade:FGFR1 13 8.92e-02 0.272000 1.80e-01
SUMOylation of transcription factors 16 5.96e-02 -0.272000 1.33e-01
Downregulation of TGF-beta receptor signaling 26 1.66e-02 -0.272000 4.80e-02
Regulation of gene expression by Hypoxia-inducible Factor 10 1.38e-01 -0.271000 2.50e-01
NRIF signals cell death from the nucleus 16 6.08e-02 -0.271000 1.34e-01
MET activates PTK2 signaling 30 1.05e-02 0.270000 3.39e-02
Signaling by WNT in cancer 29 1.19e-02 -0.270000 3.70e-02
Protein methylation 15 7.06e-02 -0.270000 1.51e-01
RHO GTPases Activate NADPH Oxidases 21 3.25e-02 -0.270000 8.14e-02
Regulation of RUNX3 expression and activity 55 5.51e-04 -0.269000 2.92e-03
InlB-mediated entry of Listeria monocytogenes into host cell 13 9.37e-02 -0.269000 1.87e-01
DNA Replication Pre-Initiation 101 3.15e-06 -0.269000 3.60e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 2.06e-04 -0.268000 1.28e-03
Defective B3GAT3 causes JDSSDHD 16 6.33e-02 0.268000 1.39e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 71 9.43e-05 -0.268000 6.57e-04
Rev-mediated nuclear export of HIV RNA 35 6.09e-03 -0.268000 2.21e-02
Sulfur amino acid metabolism 25 2.04e-02 -0.268000 5.77e-02
Signaling by CSF3 (G-CSF) 30 1.11e-02 -0.268000 3.53e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 1.43e-01 -0.268000 2.56e-01
HIV Transcription Initiation 45 1.91e-03 -0.268000 8.20e-03
RNA Polymerase II HIV Promoter Escape 45 1.91e-03 -0.268000 8.20e-03
RNA Polymerase II Promoter Escape 45 1.91e-03 -0.268000 8.20e-03
RNA Polymerase II Transcription Initiation 45 1.91e-03 -0.268000 8.20e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.91e-03 -0.268000 8.20e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.91e-03 -0.268000 8.20e-03
Orc1 removal from chromatin 66 1.73e-04 -0.267000 1.10e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.09e-01 0.267000 2.10e-01
Estrogen-dependent gene expression 92 1.00e-05 -0.267000 9.67e-05
Asymmetric localization of PCP proteins 61 3.22e-04 -0.266000 1.86e-03
Stabilization of p53 54 7.14e-04 -0.266000 3.67e-03
Hyaluronan metabolism 14 8.46e-02 0.266000 1.73e-01
Nuclear import of Rev protein 34 7.26e-03 -0.266000 2.55e-02
Metabolism of polyamines 56 5.79e-04 -0.266000 3.03e-03
COPII-mediated vesicle transport 63 2.64e-04 -0.266000 1.56e-03
Signaling by Retinoic Acid 35 6.65e-03 -0.265000 2.36e-02
Extracellular matrix organization 253 4.11e-13 0.265000 1.09e-11
Nuclear events mediated by NFE2L2 76 6.60e-05 -0.265000 4.74e-04
Chemokine receptors bind chemokines 30 1.22e-02 0.264000 3.75e-02
Integrin cell surface interactions 76 6.82e-05 0.264000 4.87e-04
Response of EIF2AK1 (HRI) to heme deficiency 14 8.72e-02 -0.264000 1.77e-01
Cyclin A:Cdk2-associated events at S phase entry 82 3.68e-05 -0.264000 2.85e-04
Transcriptional activation of mitochondrial biogenesis 50 1.27e-03 -0.264000 5.82e-03
Calnexin/calreticulin cycle 26 2.04e-02 -0.263000 5.77e-02
HS-GAG degradation 21 3.72e-02 0.263000 9.12e-02
TNFs bind their physiological receptors 18 5.38e-02 0.263000 1.23e-01
Interaction between L1 and Ankyrins 26 2.08e-02 0.262000 5.83e-02
Prefoldin mediated transfer of substrate to CCT/TriC 25 2.34e-02 -0.262000 6.37e-02
GPCR ligand binding 197 2.47e-10 0.262000 5.17e-09
SUMOylation of DNA replication proteins 44 2.76e-03 -0.261000 1.13e-02
Regulation of HSF1-mediated heat shock response 79 6.18e-05 -0.261000 4.50e-04
Presynaptic depolarization and calcium channel opening 10 1.54e-01 0.260000 2.69e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.36e-01 -0.259000 2.48e-01
PPARA activates gene expression 106 4.14e-06 -0.259000 4.51e-05
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 8.97e-04 -0.259000 4.43e-03
TNF signaling 56 8.45e-04 -0.258000 4.24e-03
Regulation of APC/C activators between G1/S and early anaphase 76 1.15e-04 -0.256000 7.93e-04
SUMO E3 ligases SUMOylate target proteins 159 2.84e-08 -0.255000 4.57e-07
G alpha (q) signalling events 128 6.51e-07 0.255000 8.90e-06
Acetylcholine Neurotransmitter Release Cycle 11 1.46e-01 0.253000 2.60e-01
tRNA processing in the nucleus 59 7.72e-04 -0.253000 3.92e-03
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 12 1.30e-01 -0.253000 2.40e-01
Negative regulation of MET activity 19 5.73e-02 -0.252000 1.30e-01
Synthesis of DNA 112 4.16e-06 -0.252000 4.51e-05
Export of Viral Ribonucleoproteins from Nucleus 33 1.24e-02 -0.252000 3.80e-02
GABA receptor activation 39 6.58e-03 0.252000 2.35e-02
Interactions of Vpr with host cellular proteins 37 8.17e-03 -0.251000 2.78e-02
Vpr-mediated nuclear import of PICs 34 1.13e-02 -0.251000 3.54e-02
Cholesterol biosynthesis 27 2.39e-02 -0.251000 6.49e-02
Aberrant regulation of mitotic cell cycle due to RB1 defects 33 1.28e-02 -0.250000 3.89e-02
KEAP1-NFE2L2 pathway 101 1.38e-05 -0.250000 1.21e-04
Thrombin signalling through proteinase activated receptors (PARs) 25 3.03e-02 0.250000 7.79e-02
Retinoid metabolism and transport 29 1.98e-02 0.250000 5.64e-02
Aspartate and asparagine metabolism 10 1.71e-01 0.250000 2.91e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.48e-02 -0.250000 6.69e-02
ADP signalling through P2Y purinoceptor 12 14 1.06e-01 0.249000 2.07e-01
Nonhomologous End-Joining (NHEJ) 35 1.08e-02 -0.249000 3.45e-02
p75NTR recruits signalling complexes 13 1.21e-01 -0.249000 2.27e-01
Cellular response to heat stress 97 2.41e-05 -0.248000 1.95e-04
RHOBTB2 GTPase cycle 23 4.00e-02 -0.247000 9.63e-02
Formation of WDR5-containing histone-modifying complexes 42 5.56e-03 -0.247000 2.05e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 37 9.26e-03 -0.247000 3.07e-02
FLT3 Signaling 35 1.17e-02 -0.246000 3.63e-02
NFE2L2 regulating anti-oxidant/detoxification enzymes 14 1.11e-01 -0.246000 2.13e-01
ABC-family proteins mediated transport 93 4.24e-05 -0.246000 3.16e-04
Transcription of E2F targets under negative control by DREAM complex 18 7.11e-02 -0.246000 1.52e-01
Cytosolic iron-sulfur cluster assembly 13 1.26e-01 -0.245000 2.35e-01
DNA Damage Recognition in GG-NER 38 8.97e-03 -0.245000 3.00e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.51e-02 -0.245000 6.75e-02
Chondroitin sulfate biosynthesis 15 1.01e-01 0.245000 1.99e-01
Regulation of lipid metabolism by PPARalpha 108 1.18e-05 -0.244000 1.08e-04
SUMOylation 165 6.57e-08 -0.244000 1.01e-06
APC/C-mediated degradation of cell cycle proteins 81 1.49e-04 -0.244000 9.76e-04
Regulation of mitotic cell cycle 81 1.49e-04 -0.244000 9.76e-04
Inhibition of DNA recombination at telomere 27 2.83e-02 -0.244000 7.41e-02
Prolonged ERK activation events 14 1.14e-01 -0.244000 2.18e-01
SUMOylation of SUMOylation proteins 35 1.27e-02 -0.243000 3.88e-02
P2Y receptors 10 1.83e-01 0.243000 3.05e-01
HDACs deacetylate histones 37 1.05e-02 -0.243000 3.38e-02
C-type lectin receptors (CLRs) 121 3.86e-06 -0.243000 4.28e-05
RHOBTB GTPase Cycle 35 1.29e-02 -0.243000 3.90e-02
Processing and activation of SUMO 10 1.85e-01 -0.242000 3.06e-01
Collagen formation 84 1.27e-04 0.242000 8.60e-04
MTOR signalling 41 7.36e-03 -0.242000 2.57e-02
Sema4D in semaphorin signaling 24 4.09e-02 0.241000 9.79e-02
Disorders of Developmental Biology 12 1.48e-01 -0.241000 2.63e-01
Disorders of Nervous System Development 12 1.48e-01 -0.241000 2.63e-01
Loss of function of MECP2 in Rett syndrome 12 1.48e-01 -0.241000 2.63e-01
Pervasive developmental disorders 12 1.48e-01 -0.241000 2.63e-01
Glycogen storage diseases 14 1.20e-01 -0.240000 2.26e-01
SUMOylation of DNA methylation proteins 16 9.64e-02 -0.240000 1.92e-01
Viral Messenger RNA Synthesis 44 5.91e-03 -0.240000 2.16e-02
PKMTs methylate histone lysines 42 7.25e-03 -0.240000 2.55e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity 31 2.10e-02 -0.239000 5.89e-02
DNA Replication 124 4.22e-06 -0.239000 4.54e-05
PTEN Regulation 138 1.25e-06 -0.239000 1.63e-05
Cleavage of the damaged pyrimidine 21 5.78e-02 -0.239000 1.30e-01
Depyrimidination 21 5.78e-02 -0.239000 1.30e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 21 5.78e-02 -0.239000 1.30e-01
Nucleotide Excision Repair 110 1.51e-05 -0.239000 1.31e-04
Signaling by BMP 24 4.29e-02 0.239000 1.02e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.96e-02 -0.238000 5.60e-02
Effects of PIP2 hydrolysis 23 4.80e-02 0.238000 1.13e-01
Diseases associated with N-glycosylation of proteins 20 6.57e-02 0.238000 1.43e-01
Epigenetic regulation of gene expression 133 2.24e-06 -0.238000 2.59e-05
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 3.07e-04 -0.237000 1.79e-03
Glycolysis 65 9.97e-04 -0.236000 4.86e-03
Nucleotide-like (purinergic) receptors 14 1.27e-01 0.236000 2.36e-01
CLEC7A (Dectin-1) induces NFAT activation 11 1.77e-01 -0.235000 2.97e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 2.14e-02 -0.235000 6.00e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 28 3.15e-02 -0.235000 8.00e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 2.02e-04 -0.235000 1.25e-03
Long-term potentiation 19 7.67e-02 0.235000 1.62e-01
Vitamin B5 (pantothenate) metabolism 16 1.04e-01 -0.235000 2.04e-01
Synthesis of IP3 and IP4 in the cytosol 22 5.84e-02 0.233000 1.31e-01
Signaling by PDGFR in disease 20 7.16e-02 -0.233000 1.53e-01
Defective pyroptosis 20 7.17e-02 -0.233000 1.53e-01
IRAK1 recruits IKK complex 14 1.32e-01 -0.233000 2.43e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 14 1.32e-01 -0.233000 2.43e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 30 2.76e-02 0.232000 7.25e-02
Dual incision in TC-NER 65 1.20e-03 -0.232000 5.65e-03
Termination of translesion DNA synthesis 31 2.52e-02 -0.232000 6.76e-02
Platelet Adhesion to exposed collagen 11 1.83e-01 0.232000 3.04e-01
Norepinephrine Neurotransmitter Release Cycle 13 1.47e-01 0.232000 2.62e-01
Striated Muscle Contraction 35 1.77e-02 0.232000 5.08e-02
Hedgehog ligand biogenesis 60 1.94e-03 -0.231000 8.30e-03
Neurexins and neuroligins 39 1.25e-02 0.231000 3.81e-02
Phase 2 - plateau phase 11 1.84e-01 0.231000 3.06e-01
Signaling by the B Cell Receptor (BCR) 105 4.36e-05 -0.231000 3.24e-04
Synthesis of PIPs at the late endosome membrane 11 1.85e-01 -0.231000 3.06e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 16 1.10e-01 0.231000 2.12e-01
Gene Silencing by RNA 78 4.35e-04 -0.230000 2.41e-03
O-linked glycosylation 86 2.29e-04 0.230000 1.40e-03
Glycogen synthesis 13 1.51e-01 -0.230000 2.66e-01
Carnitine metabolism 14 1.37e-01 -0.230000 2.48e-01
Energy dependent regulation of mTOR by LKB1-AMPK 29 3.25e-02 -0.229000 8.14e-02
Dual Incision in GG-NER 41 1.13e-02 -0.229000 3.54e-02
Platelet Aggregation (Plug Formation) 30 3.05e-02 0.228000 7.79e-02
IKK complex recruitment mediated by RIP1 23 5.82e-02 -0.228000 1.31e-01
p53-Dependent G1 DNA Damage Response 61 2.06e-03 -0.228000 8.62e-03
p53-Dependent G1/S DNA damage checkpoint 61 2.06e-03 -0.228000 8.62e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 51 4.86e-03 -0.228000 1.81e-02
Non-integrin membrane-ECM interactions 57 2.92e-03 0.228000 1.18e-02
Negative regulation of FLT3 13 1.55e-01 -0.228000 2.71e-01
Meiotic synapsis 32 2.65e-02 -0.227000 7.01e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 1.17e-01 -0.226000 2.22e-01
SARS-CoV-2 Infection 262 3.61e-10 -0.225000 7.33e-09
Transcriptional regulation by small RNAs 54 4.26e-03 -0.225000 1.61e-02
SIRT1 negatively regulates rRNA expression 15 1.32e-01 -0.225000 2.43e-01
RNA polymerase II transcribes snRNA genes 71 1.07e-03 -0.225000 5.13e-03
The NLRP3 inflammasome 16 1.20e-01 -0.224000 2.27e-01
Defects in vitamin and cofactor metabolism 20 8.28e-02 -0.224000 1.71e-01
DNA Damage Bypass 45 9.34e-03 -0.224000 3.09e-02
Downstream signal transduction 28 4.05e-02 -0.224000 9.71e-02
Metabolism of folate and pterines 17 1.10e-01 -0.224000 2.12e-01
Adenylate cyclase activating pathway 10 2.21e-01 0.223000 3.51e-01
Regulation of RAS by GAPs 65 1.88e-03 -0.223000 8.20e-03
UCH proteinases 85 3.83e-04 -0.223000 2.15e-03
Constitutive Signaling by Overexpressed ERBB2 11 2.01e-01 -0.223000 3.26e-01
Somitogenesis 50 6.47e-03 -0.223000 2.32e-02
Unwinding of DNA 10 2.23e-01 -0.223000 3.52e-01
Removal of the Flap Intermediate 14 1.49e-01 -0.223000 2.64e-01
SUMOylation of ubiquitinylation proteins 39 1.63e-02 -0.222000 4.75e-02
RMTs methylate histone arginines 33 2.71e-02 -0.222000 7.14e-02
Ub-specific processing proteases 157 1.58e-06 -0.222000 1.97e-05
Defects in cobalamin (B12) metabolism 12 1.83e-01 -0.222000 3.05e-01
SHC1 events in ERBB4 signaling 12 1.83e-01 0.222000 3.05e-01
Cell junction organization 92 2.37e-04 0.222000 1.43e-03
RNA Polymerase III Abortive And Retractive Initiation 41 1.41e-02 -0.222000 4.23e-02
RNA Polymerase III Transcription 41 1.41e-02 -0.222000 4.23e-02
Inflammasomes 20 8.68e-02 -0.221000 1.77e-01
Erythropoietin activates RAS 13 1.68e-01 -0.221000 2.88e-01
RNA Polymerase III Transcription Initiation 36 2.20e-02 -0.221000 6.09e-02
Transcriptional Regulation by E2F6 33 2.87e-02 -0.220000 7.50e-02
Uptake and actions of bacterial toxins 24 6.21e-02 -0.220000 1.37e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 1.70e-01 -0.220000 2.91e-01
Golgi Associated Vesicle Biogenesis 54 5.26e-03 -0.220000 1.95e-02
Activation of GABAB receptors 31 3.49e-02 0.219000 8.62e-02
GABA B receptor activation 31 3.49e-02 0.219000 8.62e-02
TCF dependent signaling in response to WNT 161 1.67e-06 -0.219000 2.04e-05
Fatty acyl-CoA biosynthesis 31 3.51e-02 0.219000 8.65e-02
Signal transduction by L1 21 8.29e-02 0.219000 1.71e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 15 1.43e-01 -0.218000 2.56e-01
Retrograde transport at the Trans-Golgi-Network 49 8.18e-03 -0.218000 2.78e-02
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 13 1.74e-01 -0.218000 2.94e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 3.92e-02 -0.218000 9.50e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 3.92e-02 -0.218000 9.50e-02
FOXO-mediated transcription 56 4.89e-03 -0.217000 1.82e-02
HCMV Infection 100 1.76e-04 -0.217000 1.11e-03
SHC1 events in EGFR signaling 10 2.35e-01 0.217000 3.66e-01
RAS processing 22 7.84e-02 -0.217000 1.64e-01
TCR signaling 100 1.87e-04 -0.216000 1.17e-03
MicroRNA (miRNA) biogenesis 25 6.15e-02 -0.216000 1.36e-01
PCP/CE pathway 87 4.97e-04 -0.216000 2.71e-03
Ephrin signaling 18 1.13e-01 0.216000 2.15e-01
PIWI-interacting RNA (piRNA) biogenesis 20 9.44e-02 -0.216000 1.88e-01
Negative regulation of MAPK pathway 41 1.68e-02 -0.216000 4.86e-02
MAPK6/MAPK4 signaling 84 6.35e-04 -0.216000 3.30e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 72 1.58e-03 -0.215000 7.01e-03
Transcriptional Regulation by TP53 338 1.12e-11 -0.215000 2.68e-10
NOTCH1 Intracellular Domain Regulates Transcription 47 1.09e-02 -0.215000 3.48e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 49 9.37e-03 -0.215000 3.09e-02
The role of Nef in HIV-1 replication and disease pathogenesis 24 6.92e-02 -0.214000 1.49e-01
G1/S DNA Damage Checkpoints 62 3.62e-03 -0.214000 1.42e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 2.01e-01 0.213000 3.26e-01
HS-GAG biosynthesis 22 8.37e-02 0.213000 1.72e-01
SARS-CoV Infections 373 1.86e-12 -0.213000 4.79e-11
Collagen biosynthesis and modifying enzymes 64 3.27e-03 0.213000 1.30e-02
B-WICH complex positively regulates rRNA expression 38 2.34e-02 -0.213000 6.37e-02
Activated NTRK2 signals through FRS2 and FRS3 11 2.22e-01 -0.212000 3.52e-01
Post-translational modification: synthesis of GPI-anchored proteins 58 5.20e-03 0.212000 1.93e-02
EPH-ephrin mediated repulsion of cells 44 1.50e-02 0.212000 4.45e-02
Protein-protein interactions at synapses 61 4.22e-03 0.212000 1.61e-02
Transport of the SLBP independent Mature mRNA 35 3.04e-02 -0.212000 7.79e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 1.11e-01 -0.211000 2.13e-01
Infectious disease 824 1.42e-24 -0.211000 5.78e-23
RHO GTPases Activate ROCKs 19 1.12e-01 0.211000 2.14e-01
Telomere Extension By Telomerase 21 9.51e-02 -0.210000 1.89e-01
SUMOylation of intracellular receptors 27 5.84e-02 -0.210000 1.31e-01
Listeria monocytogenes entry into host cells 17 1.33e-01 -0.210000 2.45e-01
Regulation of insulin secretion 61 4.63e-03 0.210000 1.74e-02
Advanced glycosylation endproduct receptor signaling 12 2.09e-01 0.210000 3.36e-01
ER-Phagosome pathway 79 1.38e-03 -0.208000 6.20e-03
Glucose metabolism 83 1.05e-03 -0.208000 5.07e-03
Activation of gene expression by SREBF (SREBP) 42 2.01e-02 -0.207000 5.72e-02
Mitotic Prophase 89 7.36e-04 -0.207000 3.76e-03
Biotin transport and metabolism 11 2.35e-01 -0.207000 3.66e-01
Nuclear Envelope (NE) Reassembly 68 3.23e-03 -0.207000 1.29e-02
RA biosynthesis pathway 15 1.66e-01 -0.207000 2.85e-01
Negative regulators of DDX58/IFIH1 signaling 34 3.76e-02 -0.206000 9.19e-02
ECM proteoglycans 66 3.84e-03 0.206000 1.49e-02
TP53 Regulates Transcription of Death Receptors and Ligands 11 2.41e-01 0.204000 3.72e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 23 9.04e-02 -0.204000 1.82e-01
Packaging Of Telomere Ends 13 2.04e-01 -0.203000 3.31e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste 12 2.23e-01 0.203000 3.52e-01
Muscle contraction 165 6.84e-06 0.203000 6.95e-05
Antigen processing: Ubiquitination & Proteasome degradation 291 2.80e-09 -0.203000 5.26e-08
Platelet calcium homeostasis 23 9.24e-02 0.203000 1.85e-01
G-protein mediated events 50 1.32e-02 0.203000 3.98e-02
CRMPs in Sema3A signaling 15 1.74e-01 0.203000 2.95e-01
Heme biosynthesis 13 2.07e-01 -0.202000 3.34e-01
DNA strand elongation 30 5.56e-02 -0.202000 1.27e-01
Glutathione conjugation 27 6.99e-02 -0.202000 1.50e-01
Frs2-mediated activation 12 2.27e-01 -0.201000 3.57e-01
Cargo concentration in the ER 28 6.55e-02 -0.201000 1.43e-01
Defective B4GALT7 causes EDS, progeroid type 16 1.65e-01 0.200000 2.84e-01
Gap junction assembly 20 1.21e-01 0.200000 2.27e-01
Deubiquitination 228 2.08e-07 -0.200000 2.99e-06
Rab regulation of trafficking 115 2.19e-04 -0.200000 1.35e-03
Rap1 signalling 13 2.13e-01 0.199000 3.39e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 1.33e-01 -0.199000 2.44e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 1.33e-01 -0.199000 2.44e-01
Metabolism of fat-soluble vitamins 32 5.19e-02 0.199000 1.20e-01
GPER1 signaling 37 3.66e-02 0.199000 8.99e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 33 4.84e-02 -0.199000 1.13e-01
Metabolism of Angiotensinogen to Angiotensins 13 2.15e-01 0.198000 3.43e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.16e-03 -0.198000 2.23e-02
Cleavage of the damaged purine 16 1.71e-01 -0.198000 2.91e-01
Depurination 16 1.71e-01 -0.198000 2.91e-01
Recognition and association of DNA glycosylase with site containing an affected purine 16 1.71e-01 -0.198000 2.91e-01
Positive epigenetic regulation of rRNA expression 53 1.28e-02 -0.198000 3.89e-02
Antigen processing-Cross presentation 92 1.09e-03 -0.197000 5.20e-03
PRC2 methylates histones and DNA 20 1.28e-01 -0.197000 2.37e-01
Sensory perception of taste 16 1.74e-01 0.196000 2.95e-01
eNOS activation 11 2.60e-01 -0.196000 3.92e-01
PLC beta mediated events 46 2.18e-02 0.196000 6.08e-02
RHO GTPases activate PAKs 21 1.22e-01 0.195000 2.28e-01
Fc epsilon receptor (FCERI) signaling 128 1.40e-04 -0.195000 9.38e-04
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.96e-02 -0.194000 7.66e-02
Signaling by Erythropoietin 24 1.00e-01 -0.194000 1.98e-01
Sensory Perception 153 3.65e-05 0.194000 2.84e-04
Formation of paraxial mesoderm 62 8.45e-03 -0.193000 2.85e-02
RIPK1-mediated regulated necrosis 30 6.72e-02 -0.193000 1.45e-01
Regulation of necroptotic cell death 30 6.72e-02 -0.193000 1.45e-01
Metabolic disorders of biological oxidation enzymes 22 1.18e-01 -0.193000 2.23e-01
Synthesis of very long-chain fatty acyl-CoAs 19 1.46e-01 0.193000 2.60e-01
EPH-Ephrin signaling 83 2.59e-03 0.191000 1.07e-02
Lagging Strand Synthesis 20 1.38e-01 -0.191000 2.51e-01
PECAM1 interactions 11 2.72e-01 0.191000 4.08e-01
G1/S Transition 123 2.54e-04 -0.191000 1.52e-03
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 8.02e-02 -0.191000 1.68e-01
Nuclear Envelope Breakdown 53 1.63e-02 -0.191000 4.75e-02
CASP8 activity is inhibited 10 2.96e-01 0.191000 4.36e-01
Dimerization of procaspase-8 10 2.96e-01 0.191000 4.36e-01
Regulation by c-FLIP 10 2.96e-01 0.191000 4.36e-01
RAF activation 34 5.46e-02 -0.191000 1.25e-01
Transport of the SLBP Dependant Mature mRNA 36 4.82e-02 -0.190000 1.13e-01
Bile acid and bile salt metabolism 28 8.13e-02 -0.190000 1.69e-01
Signaling by NOTCH4 81 3.11e-03 -0.190000 1.25e-02
Removal of the Flap Intermediate from the C-strand 17 1.75e-01 -0.190000 2.96e-01
NGF-stimulated transcription 35 5.22e-02 0.190000 1.20e-01
Processive synthesis on the lagging strand 15 2.04e-01 -0.189000 3.31e-01
ER to Golgi Anterograde Transport 140 1.11e-04 -0.189000 7.67e-04
DDX58/IFIH1-mediated induction of interferon-alpha/beta 66 7.86e-03 -0.189000 2.73e-02
Signaling by FGFR1 in disease 32 6.43e-02 -0.189000 1.41e-01
Base Excision Repair 51 1.97e-02 -0.189000 5.62e-02
RNA Polymerase III Transcription Termination 23 1.17e-01 -0.189000 2.22e-01
Class I MHC mediated antigen processing & presentation 352 1.27e-09 -0.189000 2.44e-08
Synthesis of PIPs at the early endosome membrane 16 1.92e-01 -0.189000 3.15e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 6.16e-02 -0.188000 1.36e-01
RUNX3 regulates p14-ARF 10 3.04e-01 -0.188000 4.42e-01
Generation of second messenger molecules 18 1.68e-01 0.188000 2.88e-01
Processing of Capped Intronless Pre-mRNA 29 8.08e-02 -0.187000 1.68e-01
Disorders of transmembrane transporters 136 1.69e-04 -0.187000 1.08e-03
Nuclear Receptor transcription pathway 43 3.40e-02 -0.187000 8.44e-02
Transcriptional Regulation by VENTX 37 4.98e-02 -0.186000 1.16e-01
Cell surface interactions at the vascular wall 104 1.04e-03 0.186000 5.05e-03
Miscellaneous transport and binding events 20 1.50e-01 0.186000 2.65e-01
Integrin signaling 23 1.23e-01 0.186000 2.31e-01
Signaling by GPCR 404 1.70e-10 0.186000 3.65e-09
Germ layer formation at gastrulation 10 3.12e-01 -0.185000 4.49e-01
PI3K events in ERBB2 signaling 14 2.33e-01 0.184000 3.63e-01
FGFR1 mutant receptor activation 25 1.11e-01 -0.184000 2.13e-01
Resolution of Abasic Sites (AP sites) 38 5.04e-02 -0.183000 1.17e-01
FLT3 signaling in disease 27 9.95e-02 -0.183000 1.96e-01
Neddylation 233 1.53e-06 -0.183000 1.94e-05
KSRP (KHSRP) binds and destabilizes mRNA 17 1.92e-01 -0.183000 3.15e-01
SHC-mediated cascade:FGFR2 14 2.36e-01 0.183000 3.67e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 16 2.05e-01 0.183000 3.32e-01
Acyl chain remodelling of PS 15 2.20e-01 0.183000 3.50e-01
Aquaporin-mediated transport 36 5.79e-02 0.183000 1.30e-01
ISG15 antiviral mechanism 71 7.93e-03 -0.182000 2.74e-02
trans-Golgi Network Vesicle Budding 68 9.47e-03 -0.182000 3.10e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.94e-01 -0.182000 3.17e-01
Downregulation of ERBB2:ERBB3 signaling 13 2.57e-01 -0.181000 3.89e-01
Metabolism of proteins 1630 1.73e-33 -0.181000 2.11e-31
Mitotic Anaphase 209 7.06e-06 -0.180000 7.12e-05
Signaling by CSF1 (M-CSF) in myeloid cells 31 8.21e-02 -0.180000 1.70e-01
Regulation of MECP2 expression and activity 28 9.86e-02 -0.180000 1.96e-01
Aggrephagy 34 6.94e-02 -0.180000 1.49e-01
Signaling by Activin 14 2.44e-01 0.180000 3.75e-01
GPCR downstream signalling 363 4.35e-09 0.180000 7.95e-08
Glutamate Neurotransmitter Release Cycle 20 1.65e-01 0.179000 2.84e-01
Diseases of glycosylation 125 5.43e-04 0.179000 2.89e-03
Regulation of localization of FOXO transcription factors 11 3.05e-01 -0.179000 4.42e-01
Cellular hexose transport 14 2.48e-01 0.179000 3.78e-01
Signaling by WNT 240 2.09e-06 -0.178000 2.45e-05
Signaling by FGFR in disease 54 2.37e-02 -0.178000 6.44e-02
Metabolism 1742 3.78e-34 -0.178000 5.02e-32
Telomere Maintenance 70 1.02e-02 -0.178000 3.30e-02
RNA Polymerase III Chain Elongation 18 1.92e-01 -0.178000 3.15e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 23 1.41e-01 -0.178000 2.53e-01
CTLA4 inhibitory signaling 18 1.93e-01 -0.177000 3.15e-01
Activation of AMPK downstream of NMDARs 22 1.50e-01 0.177000 2.65e-01
Recognition of DNA damage by PCNA-containing replication complex 29 9.90e-02 -0.177000 1.96e-01
Negative epigenetic regulation of rRNA expression 56 2.20e-02 -0.177000 6.09e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 1.26e-01 -0.177000 2.35e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 4.50e-02 -0.177000 1.07e-01
Neuronal System 266 7.35e-07 0.177000 9.86e-06
RNA Polymerase I Promoter Escape 38 5.96e-02 -0.177000 1.33e-01
WNT5A-dependent internalization of FZD4 14 2.54e-01 -0.176000 3.85e-01
Glycogen metabolism 24 1.36e-01 -0.176000 2.48e-01
Semaphorin interactions 63 1.57e-02 0.176000 4.65e-02
AKT phosphorylates targets in the nucleus 10 3.35e-01 -0.176000 4.68e-01
Transport of vitamins, nucleosides, and related molecules 29 1.01e-01 0.176000 1.99e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 7.64e-02 0.176000 1.61e-01
DAG and IP3 signaling 38 6.16e-02 0.175000 1.36e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 11 3.14e-01 0.175000 4.51e-01
Mitotic Metaphase and Anaphase 210 1.26e-05 -0.175000 1.13e-04
GRB2 events in ERBB2 signaling 14 2.58e-01 0.175000 3.90e-01
Regulation of IFNA/IFNB signaling 12 2.95e-01 0.175000 4.36e-01
RHO GTPases activate KTN1 10 3.41e-01 -0.174000 4.74e-01
M Phase 336 4.84e-08 -0.174000 7.53e-07
Ovarian tumor domain proteases 36 7.17e-02 -0.174000 1.53e-01
Neurotransmitter receptors and postsynaptic signal transmission 144 3.42e-04 0.173000 1.95e-03
NS1 Mediated Effects on Host Pathways 40 5.91e-02 -0.172000 1.32e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 70 1.29e-02 -0.172000 3.90e-02
Adherens junctions interactions 48 3.95e-02 0.172000 9.54e-02
tRNA processing 109 1.98e-03 -0.172000 8.40e-03
SHC1 events in ERBB2 signaling 20 1.86e-01 0.171000 3.07e-01
Heparan sulfate/heparin (HS-GAG) metabolism 41 5.83e-02 0.171000 1.31e-01
Senescence-Associated Secretory Phenotype (SASP) 54 3.01e-02 -0.171000 7.77e-02
WNT ligand biogenesis and trafficking 15 2.53e-01 -0.171000 3.83e-01
The canonical retinoid cycle in rods (twilight vision) 12 3.06e-01 0.171000 4.44e-01
Activation of G protein gated Potassium channels 18 2.10e-01 0.171000 3.37e-01
G protein gated Potassium channels 18 2.10e-01 0.171000 3.37e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 18 2.10e-01 0.171000 3.37e-01
Unblocking of NMDA receptors, glutamate binding and activation 17 2.24e-01 0.170000 3.53e-01
Post NMDA receptor activation events 67 1.62e-02 0.170000 4.74e-02
Scavenging by Class A Receptors 16 2.39e-01 0.170000 3.71e-01
FCGR3A-mediated IL10 synthesis 37 7.46e-02 0.169000 1.58e-01
Plasma lipoprotein assembly 11 3.32e-01 0.169000 4.66e-01
Activation of NMDA receptors and postsynaptic events 78 9.91e-03 0.169000 3.22e-02
SARS-CoV-2 activates/modulates innate and adaptive immune responses 101 3.37e-03 -0.169000 1.33e-02
Chaperonin-mediated protein folding 75 1.15e-02 -0.169000 3.60e-02
Cell-Cell communication 121 1.35e-03 0.169000 6.12e-03
Hedgehog ‘on’ state 82 8.32e-03 -0.169000 2.81e-02
Inwardly rectifying K+ channels 23 1.62e-01 0.169000 2.81e-01
Leading Strand Synthesis 14 2.76e-01 -0.168000 4.12e-01
Polymerase switching 14 2.76e-01 -0.168000 4.12e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways 15 2.60e-01 -0.168000 3.92e-01
Ca-dependent events 34 9.06e-02 0.168000 1.82e-01
Regulation of TP53 Expression and Degradation 36 8.19e-02 -0.168000 1.70e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 12 3.16e-01 -0.167000 4.52e-01
Tight junction interactions 17 2.33e-01 0.167000 3.63e-01
Transcriptional Regulation by NPAS4 31 1.07e-01 -0.167000 2.08e-01
Assembly of the ORC complex at the origin of replication 15 2.63e-01 -0.167000 3.95e-01
HCMV Early Events 77 1.13e-02 -0.167000 3.54e-02
Apoptotic cleavage of cellular proteins 35 8.73e-02 0.167000 1.77e-01
Signaling by ALK fusions and activated point mutants 53 3.60e-02 -0.167000 8.86e-02
Signaling by ALK in cancer 53 3.60e-02 -0.167000 8.86e-02
TNFR2 non-canonical NF-kB pathway 85 8.14e-03 -0.166000 2.78e-02
Nuclear Pore Complex (NPC) Disassembly 36 8.46e-02 -0.166000 1.73e-01
Interferon gamma signaling 72 1.50e-02 0.166000 4.45e-02
Cytochrome P450 - arranged by substrate type 33 9.93e-02 -0.166000 1.96e-01
ATF6 (ATF6-alpha) activates chaperones 12 3.20e-01 -0.166000 4.57e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 1.44e-01 -0.166000 2.57e-01
IL-6-type cytokine receptor ligand interactions 13 3.03e-01 0.165000 4.41e-01
RAB GEFs exchange GTP for GDP on RABs 84 8.98e-03 -0.165000 3.00e-02
RNA Polymerase I Transcription Initiation 47 5.06e-02 -0.165000 1.17e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.40e-01 -0.165000 3.71e-01
COPI-independent Golgi-to-ER retrograde traffic 45 5.66e-02 -0.164000 1.29e-01
Cell-cell junction organization 67 2.04e-02 0.164000 5.77e-02
Platelet sensitization by LDL 17 2.43e-01 -0.164000 3.74e-01
RNA Polymerase I Promoter Clearance 57 3.26e-02 -0.164000 8.14e-02
RNA Polymerase I Transcription 57 3.26e-02 -0.164000 8.14e-02
Aspirin ADME 15 2.74e-01 -0.163000 4.11e-01
G1/S-Specific Transcription 23 1.77e-01 -0.163000 2.97e-01
Gene expression (Transcription) 1352 2.93e-23 -0.163000 1.16e-21
Metabolism of nitric oxide: NOS3 activation and regulation 15 2.77e-01 -0.162000 4.13e-01
Phase I - Functionalization of compounds 67 2.20e-02 -0.162000 6.09e-02
Bacterial Infection Pathways 63 2.63e-02 -0.162000 6.98e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 1.61e-01 -0.162000 2.81e-01
Synthesis of PIPs at the plasma membrane 51 4.59e-02 -0.162000 1.08e-01
Regulation of TP53 Activity 149 6.76e-04 -0.161000 3.49e-03
Meiosis 50 4.84e-02 -0.161000 1.13e-01
RHOV GTPase cycle 34 1.04e-01 -0.161000 2.03e-01
TNFR1-induced proapoptotic signaling 24 1.72e-01 -0.161000 2.92e-01
Activation of HOX genes during differentiation 67 2.27e-02 -0.161000 6.24e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 67 2.27e-02 -0.161000 6.24e-02
Transport to the Golgi and subsequent modification 165 3.69e-04 -0.161000 2.09e-03
Early SARS-CoV-2 Infection Events 32 1.15e-01 -0.161000 2.20e-01
Transcriptional regulation by RUNX1 165 4.09e-04 -0.160000 2.28e-03
Regulation of TP53 Degradation 35 1.03e-01 -0.159000 2.02e-01
Synthesis of PC 23 1.87e-01 -0.159000 3.09e-01
Anti-inflammatory response favouring Leishmania parasite infection 66 2.62e-02 0.158000 6.97e-02
Leishmania parasite growth and survival 66 2.62e-02 0.158000 6.97e-02
RHOH GTPase cycle 31 1.28e-01 -0.158000 2.38e-01
G beta:gamma signalling through BTK 12 3.47e-01 0.157000 4.78e-01
Separation of Sister Chromatids 166 5.07e-04 -0.157000 2.75e-03
Transcriptional regulation by RUNX2 113 4.09e-03 -0.156000 1.57e-02
ADORA2B mediated anti-inflammatory cytokines production 34 1.16e-01 0.156000 2.20e-01
ROS and RNS production in phagocytes 29 1.47e-01 -0.156000 2.61e-01
Protein folding 81 1.56e-02 -0.156000 4.60e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 36 1.07e-01 -0.155000 2.08e-01
G beta:gamma signalling through PLC beta 14 3.15e-01 0.155000 4.51e-01
Attachment and Entry 9694614 15 3.01e-01 0.154000 4.39e-01
Cyclin A/B1/B2 associated events during G2/M transition 21 2.22e-01 0.154000 3.51e-01
MET promotes cell motility 40 9.23e-02 0.154000 1.85e-01
Nuclear events stimulated by ALK signaling in cancer 17 2.72e-01 -0.154000 4.08e-01
Glucagon signaling in metabolic regulation 26 1.76e-01 0.153000 2.97e-01
DNA Repair 278 1.14e-05 -0.153000 1.06e-04
DNA methylation 11 3.80e-01 -0.153000 5.13e-01
RNA Polymerase I Promoter Opening 10 4.02e-01 -0.153000 5.35e-01
A tetrasaccharide linker sequence is required for GAG synthesis 20 2.37e-01 0.153000 3.68e-01
Telomere C-strand synthesis initiation 13 3.41e-01 -0.153000 4.74e-01
Dopamine Neurotransmitter Release Cycle 19 2.50e-01 0.152000 3.80e-01
Cytosolic sensors of pathogen-associated DNA 62 3.80e-02 -0.152000 9.24e-02
CaM pathway 32 1.36e-01 0.152000 2.48e-01
Calmodulin induced events 32 1.36e-01 0.152000 2.48e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 11 3.82e-01 -0.152000 5.14e-01
G alpha (i) signalling events 174 5.42e-04 0.152000 2.89e-03
NoRC negatively regulates rRNA expression 53 5.60e-02 -0.152000 1.28e-01
TP53 Regulates Transcription of Cell Cycle Genes 43 8.54e-02 -0.152000 1.74e-01
CD209 (DC-SIGN) signaling 20 2.41e-01 -0.152000 3.72e-01
Signaling by TGF-beta Receptor Complex 92 1.21e-02 -0.151000 3.74e-02
Signaling by Leptin 11 3.85e-01 -0.151000 5.16e-01
RUNX2 regulates osteoblast differentiation 21 2.30e-01 0.151000 3.61e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 23 2.12e-01 0.150000 3.38e-01
SUMOylation of immune response proteins 11 3.88e-01 -0.150000 5.20e-01
Sensory processing of sound by outer hair cells of the cochlea 38 1.09e-01 0.150000 2.10e-01
Diseases of carbohydrate metabolism 29 1.62e-01 -0.150000 2.81e-01
Transcriptional regulation by RUNX3 95 1.16e-02 -0.150000 3.63e-02
Lysosome Vesicle Biogenesis 31 1.49e-01 -0.150000 2.63e-01
Membrane Trafficking 565 1.38e-09 -0.150000 2.62e-08
LDL clearance 17 2.86e-01 -0.150000 4.24e-01
G alpha (s) signalling events 89 1.48e-02 0.150000 4.41e-02
RAF-independent MAPK1/3 activation 20 2.49e-01 0.149000 3.80e-01
EPHB-mediated forward signaling 39 1.09e-01 0.148000 2.10e-01
Binding and Uptake of Ligands by Scavenger Receptors 34 1.35e-01 0.148000 2.47e-01
Regulation of FZD by ubiquitination 16 3.05e-01 -0.148000 4.42e-01
RNA Polymerase II Transcription 1195 1.28e-17 -0.148000 3.74e-16
Transmission across Chemical Synapses 190 4.72e-04 0.147000 2.60e-03
Intra-Golgi and retrograde Golgi-to-ER traffic 183 6.01e-04 -0.147000 3.14e-03
Cellular Senescence 127 4.23e-03 -0.147000 1.61e-02
Impaired BRCA2 binding to PALB2 21 2.44e-01 0.147000 3.75e-01
Neurotransmitter release cycle 36 1.29e-01 0.146000 2.39e-01
Infection with Mycobacterium tuberculosis 27 1.88e-01 -0.146000 3.11e-01
Diseases associated with glycosylation precursor biosynthesis 15 3.28e-01 -0.146000 4.63e-01
Iron uptake and transport 52 6.93e-02 -0.146000 1.49e-01
Extension of Telomeres 49 7.80e-02 -0.146000 1.64e-01
Cell Cycle, Mitotic 466 8.01e-08 -0.146000 1.21e-06
Response of Mtb to phagocytosis 23 2.28e-01 -0.145000 3.58e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 29 1.76e-01 0.145000 2.97e-01
Fatty acid metabolism 142 2.86e-03 -0.145000 1.16e-02
Acyl chain remodelling of PG 11 4.06e-01 0.145000 5.37e-01
Mitotic G1 phase and G1/S transition 139 3.29e-03 -0.145000 1.30e-02
Surfactant metabolism 18 2.89e-01 0.145000 4.27e-01
Activation of BAD and translocation to mitochondria 14 3.51e-01 -0.144000 4.82e-01
Platelet degranulation 111 8.96e-03 0.144000 3.00e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 22 2.45e-01 -0.143000 3.76e-01
Lysine catabolism 11 4.11e-01 -0.143000 5.40e-01
PERK regulates gene expression 30 1.75e-01 -0.143000 2.96e-01
Ion homeostasis 48 8.79e-02 0.142000 1.78e-01
Signaling by FGFR4 in disease 11 4.14e-01 -0.142000 5.42e-01
Gluconeogenesis 29 1.85e-01 -0.142000 3.06e-01
G-protein activation 17 3.12e-01 0.142000 4.49e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 4.16e-01 -0.142000 5.43e-01
Hemostasis 481 1.14e-07 0.142000 1.68e-06
Synaptic adhesion-like molecules 17 3.13e-01 0.141000 4.51e-01
Initiation of Nuclear Envelope (NE) Reformation 19 2.87e-01 -0.141000 4.25e-01
Antiviral mechanism by IFN-stimulated genes 79 3.09e-02 -0.141000 7.88e-02
Depolymerization of the Nuclear Lamina 15 3.46e-01 -0.141000 4.78e-01
DARPP-32 events 23 2.43e-01 -0.141000 3.75e-01
Prostacyclin signalling through prostacyclin receptor 13 3.80e-01 0.140000 5.14e-01
Biological oxidations 137 4.73e-03 -0.140000 1.77e-02
Integration of energy metabolism 89 2.30e-02 0.140000 6.30e-02
Cardiac conduction 100 1.61e-02 0.139000 4.72e-02
Cell Cycle 573 1.37e-08 -0.139000 2.33e-07
Signaling by ERBB2 ECD mutants 16 3.35e-01 -0.139000 4.68e-01
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 13 3.85e-01 0.139000 5.16e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 55 7.43e-02 -0.139000 1.58e-01
Transcriptional regulation of white adipocyte differentiation 81 3.15e-02 -0.138000 8.00e-02
Regulation of PTEN gene transcription 60 6.60e-02 -0.137000 1.44e-01
Assembly and cell surface presentation of NMDA receptors 33 1.73e-01 0.137000 2.94e-01
Spry regulation of FGF signaling 16 3.43e-01 -0.137000 4.76e-01
Polymerase switching on the C-strand of the telomere 26 2.29e-01 -0.136000 3.58e-01
Interleukin-12 family signaling 45 1.13e-01 -0.136000 2.17e-01
RND2 GTPase cycle 35 1.63e-01 -0.136000 2.82e-01
Interleukin-6 signaling 10 4.55e-01 -0.136000 5.79e-01
G alpha (z) signalling events 37 1.52e-01 0.136000 2.66e-01
Metabolism of steroid hormones 21 2.80e-01 0.136000 4.16e-01
Interleukin-1 signaling 108 1.49e-02 -0.136000 4.44e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 3.80e-01 0.136000 5.13e-01
Resolution of D-Loop Structures 30 1.99e-01 0.135000 3.25e-01
Intra-Golgi traffic 41 1.34e-01 -0.135000 2.45e-01
Nuclear signaling by ERBB4 29 2.09e-01 0.135000 3.36e-01
Processing of Intronless Pre-mRNAs 20 2.98e-01 -0.135000 4.37e-01
Regulation of TP53 Activity through Methylation 19 3.10e-01 -0.134000 4.48e-01
Regulation of CDH11 gene transcription 10 4.62e-01 0.134000 5.86e-01
Other interleukin signaling 20 2.99e-01 0.134000 4.38e-01
G alpha (12/13) signalling events 68 5.61e-02 0.134000 1.28e-01
RNA Polymerase I Transcription Termination 30 2.05e-01 -0.134000 3.31e-01
Vesicle-mediated transport 596 2.92e-08 -0.134000 4.65e-07
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 15 3.71e-01 -0.133000 5.06e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 15 3.71e-01 -0.133000 5.06e-01
Synthesis of PIPs at the Golgi membrane 15 3.72e-01 -0.133000 5.06e-01
Platelet activation, signaling and aggregation 223 6.29e-04 0.133000 3.27e-03
Metabolism of steroids 120 1.19e-02 -0.133000 3.70e-02
Disease 1460 6.87e-17 -0.132000 1.97e-15
FRS-mediated FGFR4 signaling 15 3.76e-01 0.132000 5.09e-01
Costimulation by the CD28 family 50 1.07e-01 -0.132000 2.08e-01
RHOB GTPase cycle 64 6.86e-02 0.132000 1.48e-01
Potential therapeutics for SARS 93 2.88e-02 -0.131000 7.51e-02
Signaling by EGFR in Cancer 21 2.99e-01 -0.131000 4.38e-01
Formation of tubulin folding intermediates by CCT/TriC 21 3.00e-01 -0.131000 4.39e-01
Maturation of nucleoprotein 9683610 11 4.55e-01 -0.130000 5.79e-01
Class I peroxisomal membrane protein import 20 3.14e-01 -0.130000 4.51e-01
Generic Transcription Pathway 1077 9.55e-13 -0.130000 2.49e-11
Response to elevated platelet cytosolic Ca2+ 115 1.63e-02 0.130000 4.75e-02
Polo-like kinase mediated events 12 4.37e-01 -0.130000 5.59e-01
PIP3 activates AKT signaling 244 4.99e-04 -0.130000 2.71e-03
Serotonin Neurotransmitter Release Cycle 14 4.02e-01 0.129000 5.35e-01
Gap junction trafficking 31 2.14e-01 0.129000 3.41e-01
Plasma lipoprotein clearance 32 2.07e-01 -0.129000 3.34e-01
SHC-mediated cascade:FGFR3 12 4.42e-01 0.128000 5.64e-01
Beta-catenin independent WNT signaling 132 1.12e-02 -0.128000 3.54e-02
Signaling by FGFR2 61 8.41e-02 -0.128000 1.73e-01
Ion transport by P-type ATPases 44 1.43e-01 0.128000 2.56e-01
G2/M Transition 182 3.03e-03 -0.128000 1.22e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 24 2.81e-01 0.127000 4.17e-01
Cytosolic sulfonation of small molecules 18 3.51e-01 0.127000 4.82e-01
Mitotic G2-G2/M phases 184 3.03e-03 -0.127000 1.22e-02
Cardiogenesis 20 3.26e-01 0.127000 4.62e-01
Chondroitin sulfate/dermatan sulfate metabolism 41 1.60e-01 0.127000 2.80e-01
G2/M Checkpoints 122 1.59e-02 -0.126000 4.68e-02
PKA activation in glucagon signalling 16 3.81e-01 0.126000 5.14e-01
Kinesins 45 1.43e-01 0.126000 2.57e-01
COPI-mediated anterograde transport 91 3.79e-02 -0.126000 9.23e-02
ABC transporters in lipid homeostasis 13 4.32e-01 0.126000 5.56e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 84 4.65e-02 0.126000 1.09e-01
Signaling by ERBB2 TMD/JMD mutants 20 3.31e-01 0.126000 4.66e-01
Inactivation, recovery and regulation of the phototransduction cascade 19 3.44e-01 -0.125000 4.77e-01
Oxidative Stress Induced Senescence 69 7.22e-02 -0.125000 1.53e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 2.90e-01 0.125000 4.28e-01
Regulated Necrosis 52 1.20e-01 -0.125000 2.26e-01
Translation of Structural Proteins 9683701 29 2.46e-01 -0.124000 3.77e-01
GAB1 signalosome 13 4.40e-01 0.124000 5.63e-01
Cyclin D associated events in G1 45 1.52e-01 -0.124000 2.66e-01
G1 Phase 45 1.52e-01 -0.124000 2.66e-01
Glycosaminoglycan metabolism 103 3.05e-02 0.124000 7.79e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 18 3.65e-01 -0.123000 4.99e-01
Neurodegenerative Diseases 18 3.65e-01 -0.123000 4.99e-01
activated TAK1 mediates p38 MAPK activation 23 3.07e-01 -0.123000 4.45e-01
Fanconi Anemia Pathway 34 2.17e-01 -0.122000 3.45e-01
Programmed Cell Death 188 3.93e-03 -0.122000 1.51e-02
Regulation of IFNG signaling 13 4.47e-01 -0.122000 5.69e-01
Organelle biogenesis and maintenance 272 5.59e-04 -0.122000 2.95e-03
Platelet homeostasis 71 7.74e-02 0.121000 1.63e-01
Homologous DNA Pairing and Strand Exchange 39 1.92e-01 0.121000 3.15e-01
RIP-mediated NFkB activation via ZBP1 17 3.90e-01 -0.120000 5.22e-01
Metabolism of water-soluble vitamins and cofactors 110 3.02e-02 -0.120000 7.78e-02
Signaling by NOTCH 175 6.43e-03 -0.120000 2.31e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 16 4.08e-01 -0.119000 5.38e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22 3.32e-01 0.119000 4.66e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function 22 3.32e-01 0.119000 4.66e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function 22 3.32e-01 0.119000 4.66e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function 22 3.32e-01 0.119000 4.66e-01
PCNA-Dependent Long Patch Base Excision Repair 21 3.45e-01 -0.119000 4.77e-01
Caspase activation via Death Receptors in the presence of ligand 15 4.26e-01 0.119000 5.51e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 24 3.14e-01 -0.119000 4.51e-01
TGF-beta receptor signaling activates SMADs 46 1.65e-01 -0.118000 2.84e-01
p38MAPK events 13 4.60e-01 0.118000 5.84e-01
Class B/2 (Secretin family receptors) 52 1.41e-01 0.118000 2.54e-01
Gastrulation 85 6.01e-02 -0.118000 1.33e-01
Regulation of TP53 Activity through Phosphorylation 85 6.05e-02 -0.118000 1.34e-01
Telomere C-strand (Lagging Strand) Synthesis 34 2.35e-01 -0.118000 3.66e-01
Signaling by FGFR2 in disease 34 2.35e-01 -0.118000 3.66e-01
DNA Damage/Telomere Stress Induced Senescence 32 2.50e-01 -0.118000 3.80e-01
Apoptosis 161 1.02e-02 -0.117000 3.30e-02
G0 and Early G1 23 3.32e-01 -0.117000 4.66e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 76 7.92e-02 0.117000 1.66e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 15 4.35e-01 -0.116000 5.58e-01
Diseases of programmed cell death 48 1.64e-01 -0.116000 2.83e-01
Ras activation upon Ca2+ influx through NMDA receptor 16 4.21e-01 0.116000 5.48e-01
Regulation of CDH11 function 10 5.25e-01 0.116000 6.45e-01
RHOU GTPase cycle 39 2.11e-01 -0.116000 3.37e-01
MASTL Facilitates Mitotic Progression 10 5.26e-01 -0.116000 6.45e-01
Meiotic recombination 26 3.08e-01 -0.116000 4.46e-01
Translation of Structural Proteins 9694635 57 1.32e-01 -0.115000 2.43e-01
Extra-nuclear estrogen signaling 63 1.18e-01 0.114000 2.23e-01
NR1H2 and NR1H3-mediated signaling 40 2.13e-01 -0.114000 3.39e-01
Maturation of nucleoprotein 9694631 15 4.45e-01 -0.114000 5.68e-01
Gap junction trafficking and regulation 33 2.58e-01 0.114000 3.90e-01
Nuclear Events (kinase and transcription factor activation) 57 1.39e-01 0.113000 2.51e-01
Interconversion of nucleotide di- and triphosphates 27 3.09e-01 -0.113000 4.47e-01
Signaling by KIT in disease 19 3.95e-01 -0.113000 5.27e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 19 3.95e-01 -0.113000 5.27e-01
The phototransduction cascade 20 3.83e-01 -0.113000 5.15e-01
DCC mediated attractive signaling 13 4.86e-01 0.112000 6.09e-01
Thromboxane signalling through TP receptor 18 4.14e-01 0.111000 5.42e-01
Opioid Signalling 79 8.75e-02 0.111000 1.77e-01
Diseases of signal transduction by growth factor receptors and second messengers 393 1.61e-04 -0.111000 1.05e-03
Processive synthesis on the C-strand of the telomere 19 4.04e-01 -0.110000 5.36e-01
Azathioprine ADME 18 4.18e-01 -0.110000 5.44e-01
Interleukin-20 family signaling 14 4.76e-01 0.110000 6.01e-01
PI Metabolism 79 9.14e-02 -0.110000 1.83e-01
Signal amplification 25 3.44e-01 0.109000 4.77e-01
Formation of the beta-catenin:TCF transactivating complex 37 2.50e-01 -0.109000 3.80e-01
Phase II - Conjugation of compounds 66 1.25e-01 -0.109000 2.33e-01
Signaling by Nuclear Receptors 213 6.10e-03 -0.109000 2.21e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 10 5.51e-01 -0.109000 6.70e-01
Chromosome Maintenance 92 7.18e-02 -0.109000 1.53e-01
BBSome-mediated cargo-targeting to cilium 21 3.89e-01 -0.109000 5.20e-01
Golgi-to-ER retrograde transport 117 4.31e-02 -0.108000 1.03e-01
PI-3K cascade:FGFR4 13 5.00e-01 0.108000 6.21e-01
MAP kinase activation 63 1.40e-01 -0.107000 2.53e-01
Zinc transporters 10 5.57e-01 -0.107000 6.75e-01
FCERI mediated MAPK activation 33 2.88e-01 0.107000 4.26e-01
Metal ion SLC transporters 18 4.33e-01 -0.107000 5.56e-01
ERKs are inactivated 13 5.07e-01 0.106000 6.26e-01
Late SARS-CoV-2 Infection Events 65 1.40e-01 -0.106000 2.53e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 14 4.93e-01 0.106000 6.15e-01
ESR-mediated signaling 152 2.49e-02 -0.106000 6.70e-02
Notch-HLH transcription pathway 28 3.35e-01 -0.105000 4.68e-01
SARS-CoV-1 activates/modulates innate immune responses 39 2.56e-01 -0.105000 3.87e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 40 2.52e-01 -0.105000 3.82e-01
Signaling by FLT3 ITD and TKD mutants 15 4.84e-01 -0.104000 6.07e-01
PI-3K cascade:FGFR3 12 5.32e-01 -0.104000 6.50e-01
Signaling by FGFR2 IIIa TM 19 4.34e-01 -0.104000 5.57e-01
Downstream signaling of activated FGFR4 20 4.23e-01 0.104000 5.49e-01
STING mediated induction of host immune responses 15 4.89e-01 0.103000 6.12e-01
CD28 dependent PI3K/Akt signaling 20 4.25e-01 -0.103000 5.51e-01
RAB geranylgeranylation 54 1.91e-01 -0.103000 3.14e-01
Asparagine N-linked glycosylation 276 3.32e-03 -0.103000 1.31e-02
Activation of kainate receptors upon glutamate binding 22 4.04e-01 0.103000 5.36e-01
Presynaptic function of Kainate receptors 15 4.91e-01 0.103000 6.14e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 3.56e-01 -0.103000 4.89e-01
Defective Intrinsic Pathway for Apoptosis 21 4.17e-01 -0.102000 5.44e-01
Sensory processing of sound 52 2.02e-01 0.102000 3.28e-01
Activation of BH3-only proteins 27 3.58e-01 -0.102000 4.91e-01
Leishmania infection 147 3.27e-02 0.102000 8.14e-02
Parasitic Infection Pathways 147 3.27e-02 0.102000 8.14e-02
Adaptive Immune System 650 9.72e-06 -0.102000 9.42e-05
Nicotinamide salvaging 16 4.80e-01 -0.102000 6.05e-01
TRAF6 mediated IRF7 activation 15 4.95e-01 -0.102000 6.16e-01
Unfolded Protein Response (UPR) 89 9.70e-02 -0.102000 1.93e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 5.78e-01 -0.102000 6.91e-01
FOXO-mediated transcription of cell cycle genes 16 4.84e-01 -0.101000 6.07e-01
Sensory processing of sound by inner hair cells of the cochlea 47 2.31e-01 0.101000 3.62e-01
Metabolism of lipids 610 2.52e-05 -0.100000 2.02e-04
L1CAM interactions 102 8.13e-02 0.100000 1.69e-01
FCGR3A-mediated phagocytosis 60 1.81e-01 0.099800 3.03e-01
Leishmania phagocytosis 60 1.81e-01 0.099800 3.03e-01
Parasite infection 60 1.81e-01 0.099800 3.03e-01
Constitutive Signaling by Aberrant PI3K in Cancer 57 1.93e-01 0.099800 3.15e-01
E2F mediated regulation of DNA replication 21 4.29e-01 -0.099700 5.54e-01
Reproduction 65 1.66e-01 -0.099500 2.85e-01
RUNX2 regulates bone development 27 3.73e-01 0.099200 5.06e-01
Activated NOTCH1 Transmits Signal to the Nucleus 30 3.48e-01 0.099100 4.79e-01
The activation of arylsulfatases 10 5.88e-01 0.098900 7.00e-01
NPAS4 regulates expression of target genes 19 4.56e-01 -0.098800 5.79e-01
Post-translational protein modification 1190 1.29e-08 -0.098800 2.22e-07
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 32 3.34e-01 -0.098700 4.68e-01
PKA activation 17 4.82e-01 0.098400 6.06e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 3.95e-01 -0.098200 5.27e-01
Transport of connexons to the plasma membrane 14 5.25e-01 0.098100 6.45e-01
TRP channels 20 4.50e-01 0.097500 5.73e-01
Tie2 Signaling 16 5.00e-01 -0.097300 6.21e-01
VEGFR2 mediated vascular permeability 27 3.82e-01 -0.097200 5.14e-01
AKT phosphorylates targets in the cytosol 14 5.29e-01 -0.097100 6.48e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 71 1.59e-01 0.096800 2.77e-01
Hedgehog ‘off’ state 106 8.58e-02 -0.096700 1.75e-01
Cell Cycle Checkpoints 228 1.22e-02 -0.096500 3.75e-02
RHOG GTPase cycle 70 1.63e-01 -0.096500 2.82e-01
RAC1 GTPase cycle 174 2.90e-02 0.096100 7.54e-02
Interleukin-12 signaling 39 3.03e-01 -0.095400 4.41e-01
Caspase activation via extrinsic apoptotic signalling pathway 23 4.29e-01 0.095200 5.54e-01
Pre-NOTCH Transcription and Translation 40 2.98e-01 -0.095100 4.37e-01
RHOA GTPase cycle 141 5.18e-02 0.095000 1.20e-01
Interleukin-17 signaling 67 1.81e-01 -0.094600 3.03e-01
Amino acid transport across the plasma membrane 25 4.15e-01 0.094200 5.42e-01
Creation of C4 and C2 activators 10 6.06e-01 0.094100 7.16e-01
Pre-NOTCH Expression and Processing 56 2.26e-01 -0.093600 3.55e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function 37 3.24e-01 0.093600 4.61e-01
Diseases of DNA Double-Strand Break Repair 37 3.24e-01 0.093600 4.61e-01
Signaling by RAF1 mutants 37 3.25e-01 0.093600 4.61e-01
Carboxyterminal post-translational modifications of tubulin 32 3.61e-01 0.093300 4.94e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 31 3.76e-01 -0.092000 5.09e-01
Regulation of NF-kappa B signaling 18 5.01e-01 -0.091700 6.21e-01
Keratan sulfate degradation 13 5.68e-01 -0.091600 6.83e-01
PKA-mediated phosphorylation of CREB 19 4.90e-01 0.091500 6.13e-01
Netrin-1 signaling 41 3.12e-01 0.091400 4.49e-01
Regulation of TP53 Activity through Association with Co-factors 11 6.00e-01 -0.091300 7.11e-01
ADP signalling through P2Y purinoceptor 1 19 4.93e-01 0.090800 6.15e-01
Glucagon-type ligand receptors 18 5.05e-01 0.090700 6.25e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 6.20e-01 -0.090700 7.27e-01
Sphingolipid de novo biosynthesis 38 3.38e-01 0.089900 4.71e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 13 5.76e-01 -0.089600 6.91e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 41 3.22e-01 -0.089500 4.58e-01
IRS-mediated signalling 37 3.50e-01 -0.088800 4.81e-01
IRE1alpha activates chaperones 50 2.78e-01 -0.088700 4.14e-01
DAP12 signaling 26 4.35e-01 0.088500 5.58e-01
FRS-mediated FGFR1 signaling 15 5.54e-01 0.088400 6.72e-01
Intracellular signaling by second messengers 281 1.11e-02 -0.088200 3.53e-02
RND1 GTPase cycle 36 3.61e-01 -0.088000 4.94e-01
O-linked glycosylation of mucins 41 3.30e-01 0.087900 4.66e-01
Interleukin-1 family signaling 136 8.05e-02 -0.086900 1.68e-01
Interleukin-4 and Interleukin-13 signaling 85 1.66e-01 0.086900 2.85e-01
NOD1/2 Signaling Pathway 36 3.67e-01 -0.086900 5.01e-01
Cargo trafficking to the periciliary membrane 45 3.18e-01 -0.086000 4.54e-01
SLC-mediated transmembrane transport 163 5.86e-02 0.085900 1.31e-01
PI3K Cascade 33 4.01e-01 -0.084600 5.33e-01
Killing mechanisms 10 6.44e-01 -0.084400 7.44e-01
WNT5:FZD7-mediated leishmania damping 10 6.44e-01 -0.084400 7.44e-01
XBP1(S) activates chaperone genes 48 3.16e-01 -0.083700 4.52e-01
GABA synthesis, release, reuptake and degradation 11 6.31e-01 0.083600 7.36e-01
Stimuli-sensing channels 76 2.11e-01 0.083000 3.37e-01
HDR through Single Strand Annealing (SSA) 33 4.09e-01 0.083000 5.38e-01
Gastrin-CREB signalling pathway via PKC and MAPK 16 5.66e-01 0.082900 6.82e-01
Syndecan interactions 26 4.68e-01 0.082300 5.92e-01
GPVI-mediated activation cascade 31 4.29e-01 -0.082100 5.54e-01
Glutamate and glutamine metabolism 11 6.39e-01 -0.081800 7.41e-01
FCERI mediated Ca+2 mobilization 31 4.31e-01 0.081700 5.56e-01
NOTCH4 Intracellular Domain Regulates Transcription 19 5.38e-01 0.081600 6.56e-01
CD28 co-stimulation 31 4.32e-01 -0.081600 5.56e-01
Processing of DNA double-strand break ends 60 2.77e-01 -0.081100 4.13e-01
Regulation of PLK1 Activity at G2/M Transition 85 1.98e-01 -0.080800 3.23e-01
NRAGE signals death through JNK 56 2.96e-01 0.080800 4.36e-01
Cargo recognition for clathrin-mediated endocytosis 89 1.90e-01 -0.080400 3.13e-01
Role of phospholipids in phagocytosis 24 4.98e-01 0.080000 6.19e-01
RHO GTPases Activate WASPs and WAVEs 36 4.08e-01 0.079800 5.38e-01
Phospholipid metabolism 181 6.63e-02 -0.079200 1.44e-01
Trafficking of GluR2-containing AMPA receptors 14 6.11e-01 -0.078400 7.20e-01
Mucopolysaccharidoses 11 6.53e-01 0.078300 7.52e-01
Activation of the pre-replicative complex 28 4.74e-01 -0.078200 5.99e-01
Visual phototransduction 59 3.00e-01 0.078100 4.38e-01
Acyl chain remodelling of PI 10 6.70e-01 0.077900 7.69e-01
Post-chaperonin tubulin folding pathway 18 5.68e-01 0.077700 6.84e-01
TRAF6 mediated NF-kB activation 23 5.26e-01 -0.076500 6.45e-01
Signaling by FLT3 fusion proteins 19 5.64e-01 -0.076400 6.81e-01
Regulation of Expression and Function of Type II Classical Cadherins 29 4.79e-01 0.076000 6.03e-01
Regulation of Homotypic Cell-Cell Adhesion 29 4.79e-01 0.076000 6.03e-01
Incretin synthesis, secretion, and inactivation 13 6.35e-01 0.075900 7.39e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 13 6.35e-01 0.075900 7.39e-01
Presynaptic phase of homologous DNA pairing and strand exchange 36 4.32e-01 0.075800 5.56e-01
Plasma lipoprotein assembly, remodeling, and clearance 56 3.27e-01 -0.075800 4.63e-01
Axon guidance 489 4.28e-03 -0.075700 1.62e-02
Constitutive Signaling by EGFRvIII 15 6.14e-01 -0.075300 7.21e-01
Signaling by EGFRvIII in Cancer 15 6.14e-01 -0.075300 7.21e-01
Mitotic Spindle Checkpoint 96 2.05e-01 -0.074900 3.31e-01
Ca2+ pathway 53 3.49e-01 0.074400 4.81e-01
Metabolism of vitamins and cofactors 158 1.07e-01 -0.074300 2.08e-01
Interleukin receptor SHC signaling 20 5.69e-01 0.073600 6.84e-01
Cytochrome c-mediated apoptotic response 13 6.51e-01 0.072500 7.50e-01
DAP12 interactions 32 4.79e-01 0.072300 6.03e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 6.28e-01 0.072300 7.33e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 6.28e-01 0.072300 7.33e-01
DNA Double-Strand Break Repair 128 1.59e-01 -0.072200 2.77e-01
Signalling to RAS 20 5.77e-01 0.072100 6.91e-01
RUNX3 regulates NOTCH signaling 14 6.44e-01 -0.071400 7.44e-01
CDC42 GTPase cycle 145 1.38e-01 0.071400 2.51e-01
Signaling by NOTCH1 72 3.00e-01 -0.070600 4.39e-01
Death Receptor Signaling 146 1.42e-01 -0.070600 2.55e-01
Insulin receptor recycling 24 5.54e-01 -0.069800 6.72e-01
Ion channel transport 137 1.62e-01 0.069200 2.82e-01
Nervous system development 509 7.92e-03 -0.069000 2.74e-02
CD28 dependent Vav1 pathway 10 7.06e-01 -0.068900 7.97e-01
Downregulation of ERBB2 signaling 27 5.37e-01 -0.068700 6.56e-01
Diseases of DNA repair 46 4.23e-01 0.068200 5.50e-01
RHOD GTPase cycle 49 4.16e-01 -0.067200 5.43e-01
MET activates RAS signaling 11 7.00e-01 0.067000 7.94e-01
Interleukin-35 Signalling 10 7.15e-01 -0.066700 8.01e-01
Signaling by Hedgehog 140 1.80e-01 -0.065700 3.02e-01
Toll Like Receptor 9 (TLR9) Cascade 105 2.46e-01 -0.065500 3.77e-01
Factors involved in megakaryocyte development and platelet production 115 2.27e-01 0.065300 3.57e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation 10 7.21e-01 0.065200 8.04e-01
MyD88-independent TLR4 cascade 107 2.47e-01 -0.064900 3.77e-01
TRIF(TICAM1)-mediated TLR4 signaling 107 2.47e-01 -0.064900 3.77e-01
Signaling by FGFR 71 3.45e-01 -0.064800 4.77e-01
Centrosome maturation 79 3.23e-01 -0.064400 4.60e-01
Recruitment of mitotic centrosome proteins and complexes 79 3.23e-01 -0.064400 4.60e-01
Regulated proteolysis of p75NTR 11 7.13e-01 -0.064000 8.00e-01
Mitotic Prometaphase 180 1.43e-01 -0.063400 2.56e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 57 4.10e-01 -0.063100 5.38e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 57 4.10e-01 -0.063100 5.38e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 57 4.10e-01 -0.063100 5.38e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 57 4.10e-01 -0.063100 5.38e-01
Signaling by NOTCH1 in Cancer 57 4.10e-01 -0.063100 5.38e-01
MECP2 regulates neuronal receptors and channels 14 6.83e-01 0.063100 7.78e-01
FGFR2 mutant receptor activation 24 5.93e-01 -0.063100 7.04e-01
Assembly of active LPL and LIPC lipase complexes 12 7.06e-01 -0.062800 7.97e-01
Negative regulation of FGFR1 signaling 25 5.88e-01 0.062700 7.00e-01
Growth hormone receptor signaling 19 6.38e-01 -0.062300 7.41e-01
Synthesis of substrates in N-glycan biosythesis 57 4.17e-01 0.062100 5.44e-01
Toll Like Receptor 3 (TLR3) Cascade 103 2.77e-01 -0.062000 4.13e-01
Downstream signaling of activated FGFR1 21 6.24e-01 0.061800 7.32e-01
EGFR downregulation 25 5.93e-01 -0.061800 7.04e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 83 3.32e-01 0.061600 4.66e-01
CS/DS degradation 10 7.37e-01 0.061400 8.16e-01
VEGFR2 mediated cell proliferation 19 6.46e-01 0.061000 7.45e-01
TP53 Regulates Transcription of Cell Death Genes 40 5.06e-01 0.060800 6.25e-01
Signaling by ERBB2 in Cancer 24 6.07e-01 0.060700 7.16e-01
Lewis blood group biosynthesis 10 7.40e-01 -0.060600 8.18e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 13 7.05e-01 0.060600 7.97e-01
Keratan sulfate biosynthesis 26 5.94e-01 -0.060400 7.05e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 14 6.96e-01 0.060400 7.91e-01
Triglyceride metabolism 24 6.09e-01 0.060300 7.18e-01
Neutrophil degranulation 406 4.03e-02 -0.059500 9.69e-02
Transcriptional Regulation by MECP2 48 4.82e-01 -0.058600 6.06e-01
Biosynthesis of specialized proresolving mediators (SPMs) 14 7.07e-01 0.058000 7.97e-01
Insulin processing 20 6.55e-01 -0.057700 7.53e-01
PI-3K cascade:FGFR1 13 7.19e-01 0.057600 8.04e-01
Signaling by ERBB2 KD Mutants 23 6.34e-01 0.057400 7.38e-01
Negative regulation of FGFR4 signaling 24 6.27e-01 0.057400 7.33e-01
Apoptotic execution phase 43 5.19e-01 0.056900 6.40e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 100 3.27e-01 -0.056800 4.62e-01
Mismatch Repair 14 7.13e-01 -0.056700 8.00e-01
TAK1-dependent IKK and NF-kappa-B activation 43 5.21e-01 -0.056500 6.43e-01
Clathrin-mediated endocytosis 128 2.76e-01 -0.055800 4.12e-01
Negative regulation of FGFR3 signaling 23 6.44e-01 -0.055600 7.44e-01
ALK mutants bind TKIs 11 7.50e-01 -0.055600 8.24e-01
Signaling by Insulin receptor 65 4.40e-01 -0.055400 5.62e-01
Signaling by FGFR3 in disease 16 7.01e-01 -0.055400 7.94e-01
Free fatty acids regulate insulin secretion 10 7.62e-01 -0.055300 8.35e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 102 3.36e-01 -0.055200 4.68e-01
Fcgamma receptor (FCGR) dependent phagocytosis 85 3.83e-01 0.054700 5.15e-01
Signaling by FGFR3 33 5.87e-01 -0.054700 7.00e-01
Sialic acid metabolism 27 6.25e-01 0.054400 7.32e-01
MyD88 dependent cascade initiated on endosome 101 3.45e-01 -0.054400 4.77e-01
Pre-NOTCH Processing in Golgi 18 6.89e-01 0.054400 7.85e-01
Signaling by high-kinase activity BRAF mutants 32 6.00e-01 0.053600 7.11e-01
Innate Immune System 841 9.19e-03 -0.053200 3.06e-02
Activation of SMO 16 7.13e-01 -0.053200 8.00e-01
MyD88 cascade initiated on plasma membrane 94 3.73e-01 -0.053200 5.06e-01
Toll Like Receptor 10 (TLR10) Cascade 94 3.73e-01 -0.053200 5.06e-01
Toll Like Receptor 5 (TLR5) Cascade 94 3.73e-01 -0.053200 5.06e-01
Oncogene Induced Senescence 32 6.04e-01 -0.053000 7.14e-01
Synthesis of glycosylphosphatidylinositol (GPI) 18 6.99e-01 0.052700 7.92e-01
RAC2 GTPase cycle 84 4.04e-01 -0.052700 5.36e-01
Role of LAT2/NTAL/LAB on calcium mobilization 17 7.07e-01 -0.052700 7.97e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 41 5.60e-01 0.052700 6.76e-01
Signaling by RAS mutants 41 5.60e-01 0.052700 6.76e-01
Signaling by moderate kinase activity BRAF mutants 41 5.60e-01 0.052700 6.76e-01
Signaling downstream of RAS mutants 41 5.60e-01 0.052700 6.76e-01
G beta:gamma signalling through CDC42 14 7.37e-01 0.051800 8.17e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 13 7.48e-01 0.051400 8.24e-01
Repression of WNT target genes 14 7.40e-01 -0.051200 8.18e-01
Interferon alpha/beta signaling 57 5.05e-01 0.051100 6.25e-01
TICAM1-dependent activation of IRF3/IRF7 12 7.64e-01 -0.050100 8.35e-01
Signaling by NTRK3 (TRKC) 16 7.30e-01 0.049800 8.11e-01
Diseases associated with glycosaminoglycan metabolism 37 6.02e-01 0.049600 7.12e-01
Signaling by ERBB2 47 5.60e-01 -0.049200 6.76e-01
Signaling by Hippo 19 7.12e-01 -0.048900 8.00e-01
Negative regulation of the PI3K/AKT network 90 4.24e-01 0.048800 5.50e-01
MHC class II antigen presentation 95 4.12e-01 -0.048700 5.40e-01
Intrinsic Pathway for Apoptosis 51 5.48e-01 -0.048700 6.66e-01
Glycerophospholipid biosynthesis 103 3.95e-01 -0.048600 5.27e-01
Maturation of spike protein 9694548 37 6.11e-01 -0.048300 7.20e-01
MET activates RAP1 and RAC1 11 7.82e-01 -0.048200 8.50e-01
FRS-mediated FGFR3 signaling 14 7.55e-01 -0.048200 8.28e-01
FCGR activation 13 7.64e-01 0.048200 8.35e-01
Nucleotide biosynthesis 12 7.74e-01 0.047900 8.43e-01
Regulation of TLR by endogenous ligand 15 7.48e-01 -0.047900 8.24e-01
SLC transporter disorders 67 5.01e-01 -0.047500 6.21e-01
Diseases of metabolism 204 2.43e-01 0.047500 3.74e-01
Diseases associated with the TLR signaling cascade 27 6.76e-01 -0.046400 7.73e-01
Diseases of Immune System 27 6.76e-01 -0.046400 7.73e-01
COPI-dependent Golgi-to-ER retrograde traffic 84 4.62e-01 -0.046400 5.86e-01
Plasma lipoprotein remodeling 20 7.20e-01 0.046300 8.04e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 7.64e-01 -0.046300 8.35e-01
Apoptotic factor-mediated response 20 7.22e-01 0.045900 8.05e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 21 7.16e-01 0.045900 8.01e-01
Developmental Biology 795 2.92e-02 -0.045800 7.58e-02
Impaired BRCA2 binding to RAD51 31 6.65e-01 0.045000 7.63e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 25 6.98e-01 0.044800 7.92e-01
Trafficking of AMPA receptors 25 6.98e-01 0.044800 7.92e-01
Regulation of beta-cell development 21 7.25e-01 -0.044400 8.07e-01
RHOJ GTPase cycle 52 5.82e-01 -0.044100 6.95e-01
Deposition of new CENPA-containing nucleosomes at the centromere 30 6.77e-01 0.044000 7.73e-01
Nucleosome assembly 30 6.77e-01 0.044000 7.73e-01
Signaling by Receptor Tyrosine Kinases 470 1.04e-01 0.043900 2.04e-01
RHO GTPases activate IQGAPs 24 7.10e-01 0.043800 7.99e-01
Formation of annular gap junctions 11 8.01e-01 0.043800 8.65e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 64 5.45e-01 -0.043700 6.65e-01
Insulin receptor signalling cascade 42 6.26e-01 -0.043400 7.33e-01
Peptide hormone metabolism 54 5.85e-01 0.042900 6.99e-01
IRS-related events triggered by IGF1R 40 6.44e-01 -0.042200 7.44e-01
Cell recruitment (pro-inflammatory response) 24 7.21e-01 0.042100 8.04e-01
Purinergic signaling in leishmaniasis infection 24 7.21e-01 0.042100 8.04e-01
AURKA Activation by TPX2 69 5.47e-01 -0.042000 6.66e-01
Signaling by TGFB family members 116 4.37e-01 -0.041800 5.59e-01
Signaling by ERBB4 51 6.07e-01 0.041600 7.17e-01
Acyl chain remodelling of PE 20 7.48e-01 -0.041400 8.24e-01
Metabolism of carbohydrates 251 2.60e-01 -0.041300 3.92e-01
N-Glycan antennae elongation 13 7.99e-01 -0.040900 8.64e-01
Immune System 1591 7.29e-03 -0.040900 2.56e-02
Transport of bile salts and organic acids, metal ions and amine compounds 47 6.38e-01 -0.039600 7.41e-01
RAC3 GTPase cycle 86 5.27e-01 0.039500 6.45e-01
Loss of Nlp from mitotic centrosomes 67 5.78e-01 -0.039400 6.91e-01
Loss of proteins required for interphase microtubule organization from the centrosome 67 5.78e-01 -0.039400 6.91e-01
Gap junction degradation 12 8.17e-01 0.038600 8.76e-01
Toll-like Receptor Cascades 156 4.07e-01 -0.038600 5.38e-01
Acyl chain remodelling of PC 19 7.72e-01 0.038400 8.42e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 7.85e-01 0.038200 8.53e-01
Signaling by FGFR1 40 6.76e-01 0.038200 7.73e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 42 6.74e-01 -0.037600 7.72e-01
Glycogen breakdown (glycogenolysis) 14 8.08e-01 -0.037500 8.69e-01
Myogenesis 26 7.44e-01 -0.037100 8.21e-01
Inositol phosphate metabolism 42 6.78e-01 0.037000 7.73e-01
Metabolism of nucleotides 85 5.56e-01 -0.037000 6.74e-01
Condensation of Prophase Chromosomes 20 7.77e-01 -0.036600 8.45e-01
RND3 GTPase cycle 36 7.11e-01 -0.035700 7.99e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 108 5.26e-01 -0.035300 6.45e-01
Toll Like Receptor 2 (TLR2) Cascade 108 5.26e-01 -0.035300 6.45e-01
Toll Like Receptor TLR1:TLR2 Cascade 108 5.26e-01 -0.035300 6.45e-01
Toll Like Receptor TLR6:TLR2 Cascade 108 5.26e-01 -0.035300 6.45e-01
Recruitment of NuMA to mitotic centrosomes 87 5.77e-01 -0.034600 6.91e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE 17 8.08e-01 -0.034100 8.69e-01
Toll Like Receptor 4 (TLR4) Cascade 136 4.95e-01 -0.033900 6.16e-01
Pentose phosphate pathway 13 8.32e-01 0.033900 8.90e-01
Sphingolipid metabolism 74 6.15e-01 0.033800 7.22e-01
Anchoring of the basal body to the plasma membrane 94 5.73e-01 0.033600 6.89e-01
Amyloid fiber formation 43 7.07e-01 0.033100 7.97e-01
MyD88 deficiency (TLR2/4) 14 8.34e-01 -0.032300 8.91e-01
RHO GTPases activate PKNs 37 7.34e-01 0.032200 8.15e-01
Paracetamol ADME 19 8.08e-01 -0.032200 8.69e-01
MAP2K and MAPK activation 36 7.41e-01 0.031900 8.18e-01
N-glycan antennae elongation in the medial/trans-Golgi 20 8.07e-01 -0.031600 8.69e-01
Pyroptosis 22 8.00e-01 -0.031300 8.64e-01
Regulation of innate immune responses to cytosolic DNA 14 8.40e-01 -0.031200 8.96e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 7.65e-01 -0.031000 8.36e-01
Downstream signaling of activated FGFR3 19 8.16e-01 -0.030800 8.76e-01
tRNA modification in the nucleus and cytosol 43 7.31e-01 -0.030300 8.11e-01
TRAF3-dependent IRF activation pathway 13 8.52e-01 0.029900 9.05e-01
Cilium Assembly 185 4.87e-01 -0.029700 6.10e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 12 8.60e-01 0.029500 9.11e-01
G-protein beta:gamma signalling 26 7.95e-01 -0.029400 8.61e-01
HDR through Homologous Recombination (HRR) 62 6.94e-01 0.028900 7.89e-01
Intraflagellar transport 49 7.30e-01 -0.028500 8.11e-01
Signal regulatory protein family interactions 11 8.70e-01 0.028400 9.20e-01
Nucleotide salvage 22 8.21e-01 0.027900 8.79e-01
Recycling pathway of L1 40 7.60e-01 0.027900 8.33e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 8.65e-01 -0.027200 9.17e-01
Transcriptional regulation of pluripotent stem cells 17 8.49e-01 0.026700 9.02e-01
Arachidonic acid metabolism 37 7.79e-01 0.026600 8.48e-01
Keratan sulfate/keratin metabolism 32 7.96e-01 -0.026500 8.61e-01
Interleukin-2 family signaling 33 7.94e-01 0.026300 8.61e-01
Resolution of Sister Chromatid Cohesion 104 6.49e-01 -0.025900 7.48e-01
G beta:gamma signalling through PI3Kgamma 19 8.46e-01 0.025800 9.01e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 8.83e-01 0.025600 9.28e-01
Nephrin family interactions 19 8.47e-01 0.025500 9.01e-01
Glycosphingolipid metabolism 36 7.91e-01 -0.025500 8.59e-01
VxPx cargo-targeting to cilium 17 8.56e-01 -0.025500 9.08e-01
Signaling by FGFR4 34 8.00e-01 0.025100 8.64e-01
Signaling by NTRKs 125 6.33e-01 0.024700 7.38e-01
Synthesis of PA 30 8.16e-01 0.024600 8.76e-01
Signal Transduction 2029 7.82e-02 0.024100 1.64e-01
Signaling by BRAF and RAF1 fusions 60 7.50e-01 0.023800 8.24e-01
Signaling by NTRK1 (TRKA) 108 6.74e-01 0.023400 7.72e-01
RET signaling 32 8.19e-01 -0.023400 8.77e-01
Regulation of actin dynamics for phagocytic cup formation 62 7.53e-01 0.023200 8.26e-01
Regulation of RUNX1 Expression and Activity 18 8.71e-01 0.022100 9.20e-01
Homology Directed Repair 98 7.08e-01 -0.021900 7.98e-01
FRS-mediated FGFR2 signaling 16 8.81e-01 0.021600 9.27e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 9.00e-01 0.021000 9.41e-01
Synthesis of PE 12 9.00e-01 0.020900 9.41e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 92 7.30e-01 -0.020800 8.11e-01
Downstream signaling of activated FGFR2 21 8.69e-01 0.020800 9.19e-01
Activation of ATR in response to replication stress 31 8.43e-01 0.020500 8.98e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 11 9.07e-01 -0.020400 9.46e-01
Interferon Signaling 164 6.55e-01 0.020200 7.53e-01
Synthesis, secretion, and deacylation of Ghrelin 11 9.12e-01 0.019300 9.50e-01
IGF1R signaling cascade 41 8.35e-01 -0.018800 8.91e-01
RHOC GTPase cycle 69 7.94e-01 0.018100 8.61e-01
Reduction of cytosolic Ca++ levels 10 9.22e-01 0.017900 9.58e-01
RHO GTPases Activate Formins 118 7.39e-01 0.017800 8.18e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11 9.21e-01 0.017400 9.58e-01
Antimicrobial peptides 20 8.93e-01 0.017300 9.37e-01
Regulation of CDH11 Expression and Function 27 8.79e-01 0.016900 9.26e-01
PI-3K cascade:FGFR2 14 9.15e-01 -0.016400 9.53e-01
Pregnenolone biosynthesis 10 9.28e-01 -0.016400 9.61e-01
Trafficking and processing of endosomal TLR 12 9.22e-01 -0.016300 9.58e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 28 8.81e-01 0.016300 9.27e-01
MAPK family signaling cascades 274 6.46e-01 -0.016200 7.45e-01
Signaling by Interleukins 375 5.92e-01 -0.016100 7.04e-01
Drug ADME 59 8.33e-01 0.015900 8.90e-01
Signaling by NTRK2 (TRKB) 23 8.97e-01 0.015600 9.39e-01
Interleukin-15 signaling 13 9.25e-01 -0.015000 9.60e-01
MET receptor recycling 10 9.35e-01 -0.015000 9.63e-01
RHOF GTPase cycle 38 8.74e-01 0.014900 9.21e-01
Signaling by SCF-KIT 40 8.72e-01 -0.014700 9.20e-01
Pyrimidine salvage 10 9.39e-01 -0.013900 9.67e-01
Activation of the AP-1 family of transcription factors 10 9.40e-01 0.013800 9.67e-01
Signaling by NODAL 15 9.27e-01 0.013800 9.60e-01
PI3K/AKT Signaling in Cancer 84 8.30e-01 0.013500 8.89e-01
Signaling by NOTCH2 29 9.03e-01 0.013100 9.43e-01
G2/M DNA damage checkpoint 56 8.67e-01 -0.013000 9.17e-01
Signaling by MET 75 8.50e-01 -0.012700 9.03e-01
Nicotinate metabolism 28 9.10e-01 -0.012400 9.49e-01
Transcriptional regulation of granulopoiesis 34 9.01e-01 -0.012400 9.41e-01
Sema3A PAK dependent Axon repulsion 16 9.33e-01 -0.012100 9.63e-01
Signaling by NOTCH3 44 8.91e-01 -0.011900 9.35e-01
ERK/MAPK targets 22 9.23e-01 0.011900 9.59e-01
Interleukin-7 signaling 19 9.34e-01 -0.011000 9.63e-01
Blood group systems biosynthesis 13 9.45e-01 -0.011000 9.71e-01
Negative regulation of FGFR2 signaling 25 9.29e-01 -0.010300 9.61e-01
VEGFA-VEGFR2 Pathway 95 8.71e-01 0.009690 9.20e-01
Triglyceride catabolism 16 9.47e-01 -0.009600 9.72e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 9.44e-01 0.009110 9.70e-01
Aflatoxin activation and detoxification 11 9.59e-01 0.008980 9.79e-01
Cell death signalling via NRAGE, NRIF and NADE 73 8.95e-01 0.008950 9.38e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 12 9.59e-01 0.008540 9.79e-01
Purine catabolism 15 9.57e-01 -0.008120 9.79e-01
Transport of small molecules 544 7.50e-01 0.008010 8.24e-01
Nucleotide catabolism 27 9.48e-01 0.007300 9.72e-01
Cytokine Signaling in Immune system 576 7.67e-01 -0.007250 8.37e-01
Condensation of Prometaphase Chromosomes 11 9.67e-01 -0.007210 9.84e-01
Signaling by Non-Receptor Tyrosine Kinases 50 9.31e-01 -0.007120 9.61e-01
Signaling by PTK6 50 9.31e-01 -0.007120 9.61e-01
Interleukin-6 family signaling 19 9.58e-01 -0.006970 9.79e-01
RHO GTPase cycle 415 8.12e-01 -0.006820 8.73e-01
IRAK4 deficiency (TLR2/4) 15 9.64e-01 0.006810 9.82e-01
Purine salvage 13 9.68e-01 0.006520 9.84e-01
Signaling by EGFR 44 9.47e-01 0.005750 9.72e-01
Interleukin-37 signaling 20 9.66e-01 -0.005550 9.84e-01
Formation of apoptosome 11 9.76e-01 0.005300 9.88e-01
Regulation of the apoptosome activity 11 9.76e-01 0.005300 9.88e-01
MAPK1/MAPK3 signaling 238 8.91e-01 -0.005170 9.35e-01
EML4 and NUDC in mitotic spindle formation 96 9.31e-01 0.005150 9.61e-01
Transferrin endocytosis and recycling 26 9.67e-01 -0.004620 9.84e-01
Signaling by PDGF 56 9.53e-01 -0.004560 9.76e-01
ZBP1(DAI) mediated induction of type I IFNs 20 9.73e-01 -0.004370 9.88e-01
Regulation of KIT signaling 15 9.78e-01 -0.004110 9.90e-01
Signaling by ALK 26 9.71e-01 -0.004070 9.87e-01
IRF3-mediated induction of type I IFN 12 9.81e-01 -0.004040 9.90e-01
Dectin-2 family 13 9.81e-01 -0.003810 9.90e-01
Termination of O-glycan biosynthesis 13 9.81e-01 0.003780 9.90e-01
Activation of RAC1 11 9.83e-01 0.003630 9.90e-01
RAF/MAP kinase cascade 233 9.26e-01 -0.003550 9.60e-01
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 9.86e-01 0.003280 9.90e-01
HDR through MMEJ (alt-NHEJ) 12 9.84e-01 -0.003250 9.90e-01
Signaling by VEGF 104 9.61e-01 0.002800 9.80e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 9.85e-01 0.002380 9.90e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 25 9.84e-01 0.002290 9.90e-01
RHO GTPase Effectors 236 9.53e-01 0.002240 9.76e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 80 9.75e-01 -0.002050 9.88e-01
Amplification of signal from the kinetochores 80 9.75e-01 -0.002050 9.88e-01
RHOQ GTPase cycle 56 9.82e-01 0.001790 9.90e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 9.92e-01 -0.001570 9.94e-01
Biosynthesis of DHA-derived SPMs 12 9.93e-01 0.001450 9.94e-01
Oncogenic MAPK signaling 76 9.85e-01 -0.001230 9.90e-01
p75 NTR receptor-mediated signalling 91 9.88e-01 -0.000931 9.91e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 11 9.96e-01 0.000898 9.96e-01
Signalling to ERKs 33 9.94e-01 -0.000723 9.95e-01
Signaling by Rho GTPases 589 9.81e-01 0.000579 9.90e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 603 9.93e-01 0.000220 9.94e-01



Detailed Gene set reports



Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin
206
set Cohesin Loading onto Chromatin
setSize 10
pANOVA 1.15e-05
s.dist -0.801
p.adjustANOVA 0.000107



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAG2 -9107
SMC1A -8937
NIPBL -8930
RAD21 -8569
WAPL -8298
SMC3 -8069
PDS5A -7642
STAG1 -5786
PDS5B -5495
MAU2 -5163

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG2 -9107
SMC1A -8937
NIPBL -8930
RAD21 -8569
WAPL -8298
SMC3 -8069
PDS5A -7642
STAG1 -5786
PDS5B -5495
MAU2 -5163



Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
424
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 7.71e-22
s.dist -0.777
p.adjustANOVA 2.82e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476
EIF3F -8392

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476
EIF3F -8392
RPS11 -8273
EIF3D -8215
RPS20 -7922
EIF3G -7905
RPS25 -7825
RPS17 -7816
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPS14 -6574
EIF3B -6339
RPS5 -6187
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPS3 -4984
RPS18 -4906
RPS27L -3238
EIF3L -1209
RPS26 577



Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
416
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 1.03e-37
s.dist -0.742
p.adjustANOVA 2.16e-35



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
EIF3H -8715
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
EIF3C -8561
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
EIF3F -8392
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
EIF3D -8215
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EIF3G -7905
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EIF3B -6339
RPS5 -6187
RPLP1 -6159
EIF3K -5872
EIF3J -5790
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
EIF3L -1209
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
RPL3 3020



SARS-CoV-1 modulates host translation machinery

SARS-CoV-1 modulates host translation machinery
1093
set SARS-CoV-1 modulates host translation machinery
setSize 36
pANOVA 2.55e-14
s.dist -0.733
p.adjustANOVA 6.92e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
RPS24 -8637
RPS3A -8610
RPS15 -8544
RPS6 -8538
RPS10 -8476
RPS11 -8273
RPS20 -7922
RPS25 -7825
RPS17 -7816
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
RPS24 -8637
RPS3A -8610
RPS15 -8544
RPS6 -8538
RPS10 -8476
RPS11 -8273
RPS20 -7922
RPS25 -7825
RPS17 -7816
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPS14 -6574
RPS5 -6187
RPS3 -4984
RPS18 -4906
HNRNPA1 -4642
RPS27L -3238
RPS26 577
EEF1A1 2882



Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1086
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 8.19e-22
s.dist -0.728
p.adjustANOVA 2.92e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476
EIF3F -8392
RPS11 -8273
EIF3D -8215
RPS20 -7922
EIF3G -7905
RPS25 -7825
RPS17 -7816
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPS14 -6574
EIF3B -6339
RPS5 -6187
EIF5 -6083
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4E -4481
RPS27L -3238
EIF4G1 -1413
EIF3L -1209
RPS26 577
EIF4A1 4037



Viral mRNA Translation

Viral mRNA Translation
1416
set Viral mRNA Translation
setSize 88
pANOVA 5.17e-32
s.dist -0.725
p.adjustANOVA 4.45e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
RPL23A -4282
GRSF1 -3549
RPS27L -3238
RPL12 -3022
DNAJC3 -2943
RPL14 -2377
RPL3L -2329
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
RPL3 3020



Peptide chain elongation

Peptide chain elongation
848
set Peptide chain elongation
setSize 88
pANOVA 1.09e-31
s.dist -0.721
p.adjustANOVA 8e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EEF2 -6569
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
EEF1A1 2882
RPL3 3020



GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
461
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 2.3e-39
s.dist -0.72
p.adjustANOVA 1.12e-36



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
EIF3C -8561
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
EIF3F -8392
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
EIF3D -8215
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EIF3G -7905
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF5B -7134
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EIF3B -6339
RPS5 -6187
RPLP1 -6159
EIF5 -6083
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4E -4481
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
EIF4G1 -1413
EIF3L -1209
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
RPL3 3020
EIF4A1 4037



Translation initiation complex formation

Translation initiation complex formation
1369
set Translation initiation complex formation
setSize 58
pANOVA 3.7e-21
s.dist -0.716
p.adjustANOVA 1.26e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476
EIF3F -8392
RPS11 -8273
EIF3D -8215
RPS20 -7922
EIF3G -7905
RPS25 -7825
RPS17 -7816
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPS14 -6574
EIF3B -6339
RPS5 -6187
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4E -4481
RPS27L -3238
EIF4G1 -1413
EIF3L -1209
PABPC1 -423
RPS26 577
EIF4A1 4037



Selenocysteine synthesis

Selenocysteine synthesis
1138
set Selenocysteine synthesis
setSize 92
pANOVA 2.02e-32
s.dist -0.714
p.adjustANOVA 1.97e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
SEPHS2 -7380
RPS4X -7375
RPS7 -7364
RPL10A -7319
SECISBP2 -7297
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
RPL23A -4282
SARS1 -3598
EEFSEC -3449
RPS27L -3238
RPL12 -3022
PSTK -2403
RPL14 -2377
RPL3L -2329
SEPSECS -1617
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
RPL3 3020



L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
621
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 2.41e-38
s.dist -0.713
p.adjustANOVA 5.89e-36



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
EIF3C -8561
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
EIF3F -8392
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
EIF3D -8215
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EIF3G -7905
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EIF3B -6339
RPS5 -6187
RPLP1 -6159
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4E -4481
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
EIF4G1 -1413
EIF3L -1209
PABPC1 -423
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
RPL3 3020
EIF4A1 4037



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
52
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 3.17e-21
s.dist -0.711
p.adjustANOVA 1.1e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
EIF3A -8865
EIF3I -8804
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPS24 -8637
RPS3A -8610
EIF3C -8561
RPS15 -8544
RPS6 -8538
RPS10 -8476
EIF3F -8392
RPS11 -8273
EIF3D -8215
RPS20 -7922
EIF3G -7905
RPS25 -7825
RPS17 -7816
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPS14 -6574
EIF3B -6339
RPS5 -6187
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4EBP1 -4509
EIF4E -4481
RPS27L -3238
EIF4G1 -1413
EIF3L -1209
PABPC1 -423
RPS26 577
EIF4A1 4037



Eukaryotic Translation Termination

Eukaryotic Translation Termination
373
set Eukaryotic Translation Termination
setSize 92
pANOVA 4.28e-32
s.dist -0.71
p.adjustANOVA 3.92e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
GSPT1 -5112
RPS3 -4984
APEH -4956
RPS18 -4906
TRMT112 -4666
RPL23A -4282
ETF1 -3370
RPS27L -3238
RPL12 -3022
N6AMT1 -2920
RPL14 -2377
RPL3L -2329
GSPT2 -1860
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
RPL3 3020



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
371
set Eukaryotic Translation Elongation
setSize 93
pANOVA 8.51e-32
s.dist -0.703
p.adjustANOVA 6.56e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
EEF1D -8834
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
EEF1D -8834
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
EEF1B2 -8057
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EEF2 -6569
EEF1G -6397
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
EEF1A2 -1314
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
EEF1A1 2882
RPL3 3020
EEF1A1P5 4167



Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion
368
set Establishment of Sister Chromatid Cohesion
setSize 10
pANOVA 0.000123
s.dist -0.701
p.adjustANOVA 0.000841



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAG2 -9107
SMC1A -8937
RAD21 -8569
WAPL -8298
SMC3 -8069
PDS5A -7642
STAG1 -5786
PDS5B -5495
ESCO2 -3037
ESCO1 -2808

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG2 -9107
SMC1A -8937
RAD21 -8569
WAPL -8298
SMC3 -8069
PDS5A -7642
STAG1 -5786
PDS5B -5495
ESCO2 -3037
ESCO1 -2808



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
780
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 2.21e-31
s.dist -0.695
p.adjustANOVA 1.54e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
UPF1 -9170
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
UPF1 -9170
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
NCBP1 -5334
GSPT1 -5112
RPS3 -4984
RPS18 -4906
RPL23A -4282
ETF1 -3370
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
GSPT2 -1860
EIF4G1 -1413
PABPC1 -423
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
NCBP2 2415
RPL26L1 2574
RPL3 3020



Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
154
set Cap-dependent Translation Initiation
setSize 118
pANOVA 2.18e-38
s.dist -0.689
p.adjustANOVA 5.89e-36



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
EIF3C -8561
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
EIF3F -8392
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
EIF3D -8215
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EIF3G -7905
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF5B -7134
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EIF3B -6339
RPS5 -6187
RPLP1 -6159
EIF2B5 -6139
EIF5 -6083
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPL27A -5778
RPL36A -5540
EIF2B3 -5301
EIF2B4 -5281
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4EBP1 -4509
EIF4E -4481
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
EIF4G1 -1413
EIF3L -1209
PABPC1 -423
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
EIF2B2 1401
EIF2B1 1899
RPL26L1 2574
RPL3 3020
EIF4A1 4037



Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
372
set Eukaryotic Translation Initiation
setSize 118
pANOVA 2.18e-38
s.dist -0.689
p.adjustANOVA 5.89e-36



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
RPL19 -8835
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
EIF3H -8715
EIF4B -8662
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
EIF3C -8561
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
EIF3F -8392
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
EIF3D -8215
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EIF3G -7905
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
EIF3M -7495
EIF1AX -7473
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
EIF5B -7134
EIF4A2 -7132
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
EIF3B -6339
RPS5 -6187
RPLP1 -6159
EIF2B5 -6139
EIF5 -6083
EIF2S2 -5971
EIF3K -5872
EIF3J -5790
RPL27A -5778
RPL36A -5540
EIF2B3 -5301
EIF2B4 -5281
RPS3 -4984
RPS18 -4906
EIF4H -4542
EIF4EBP1 -4509
EIF4E -4481
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
EIF4G1 -1413
EIF3L -1209
PABPC1 -423
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
EIF2B2 1401
EIF2B1 1899
RPL26L1 2574
RPL3 3020
EIF4A1 4037



PINK1-PRKN Mediated Mitophagy

PINK1-PRKN Mediated Mitophagy
828
set PINK1-PRKN Mediated Mitophagy
setSize 21
pANOVA 7.32e-08
s.dist -0.678
p.adjustANOVA 1.12e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATG12 -9158
TOMM6 -8911
MAP1LC3A -8317
TOMM7 -8063
UBA52 -8015
TOMM5 -7985
MFN1 -7734
TOMM22 -7514
ATG5 -7494
TOMM40 -7344
RPS27A -7158
TOMM20 -7042
TOMM70 -6875
SQSTM1 -6468
UBB -5814
UBC -4857
PINK1 -4645
MTERF3 -4593
MFN2 -4404
VDAC1 -3459

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATG12 -9158
TOMM6 -8911
MAP1LC3A -8317
TOMM7 -8063
UBA52 -8015
TOMM5 -7985
MFN1 -7734
TOMM22 -7514
ATG5 -7494
TOMM40 -7344
RPS27A -7158
TOMM20 -7042
TOMM70 -6875
SQSTM1 -6468
UBB -5814
UBC -4857
PINK1 -4645
MTERF3 -4593
MFN2 -4404
VDAC1 -3459
MAP1LC3B -2392



Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1079
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 5.41e-31
s.dist -0.669
p.adjustANOVA 3.44e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
DDIT3 -8037
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
EIF2AK4 -7745
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
ATF4 -6991
ATF2 -6807
RPS19 -6727
RPL17 -6676
RPS14 -6574
RPS5 -6187
RPLP1 -6159
EIF2S2 -5971
GCN1 -5884
RPL27A -5778
RPL36A -5540
RPS3 -4984
RPS18 -4906
RPL23A -4282
RPS27L -3238
RPL12 -3022
RPL14 -2377
RPL3L -2329
CEBPB -1995
CEBPG -856
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
IMPACT 2367
RPL26L1 2574
RPL3 3020
TRIB3 3220
ATF3 5044
ASNS 6691



Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors
375
set Expression and translocation of olfactory receptors
setSize 25
pANOVA 1.03e-08
s.dist 0.661
p.adjustANOVA 1.81e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR10G3 7119
OR1D2 6907
OR52K1 6891
OR4D9 6523
OR5AN1 6519
OR6Y1 6248
OR2AT4 6247
OR6C75 6168
OR5A2 6089
OR2M3 5964
OR51E1 5679
OR7C1 5354
OR56A1 5226
OR14J1 5107
OR5AU1 4763
OR5AS1 4493
OR5A1 4272
REEP1 4206
EBF1 4030
OR8A1 3804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR10G3 7119
OR1D2 6907
OR52K1 6891
OR4D9 6523
OR5AN1 6519
OR6Y1 6248
OR2AT4 6247
OR6C75 6168
OR5A2 6089
OR2M3 5964
OR51E1 5679
OR7C1 5354
OR56A1 5226
OR14J1 5107
OR5AU1 4763
OR5AS1 4493
OR5A1 4272
REEP1 4206
EBF1 4030
OR8A1 3804
OR2V2 3667
OR1I1 3257
LDB1 -1450
OR7D2 -1737
OR10H5 -3722



SARS-CoV-2 modulates host translation machinery

SARS-CoV-2 modulates host translation machinery
1099
set SARS-CoV-2 modulates host translation machinery
setSize 49
pANOVA 3.3e-15
s.dist -0.65
p.adjustANOVA 9.1e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
SMN1 -9207
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
RPS24 -8637
RPS3A -8610
RPS15 -8544
RPS6 -8538
RPS10 -8476
SNRPG -8415
RPS11 -8273
SNRPF -8202
SNRPB -8171
RPS20 -7922
RPS25 -7825

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMN1 -9207
RPSA -9069
RPS27 -9023
RPS21 -8956
RPS29 -8889
RPS23 -8794
FAU -8778
RPS16 -8752
RPS15A -8723
RPS24 -8637
RPS3A -8610
RPS15 -8544
RPS6 -8538
RPS10 -8476
SNRPG -8415
RPS11 -8273
SNRPF -8202
SNRPB -8171
RPS20 -7922
RPS25 -7825
RPS17 -7816
GEMIN5 -7765
RPS12 -7764
RPS9 -7651
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPS14 -6574
RPS5 -6187
SNRPD3 -5542
RPS3 -4984
RPS18 -4906
SNRPD2 -4517
GEMIN7 -3951
RPS27L -3238
GEMIN4 -2768
GEMIN6 -2759
SNRPE -2750
SNRPD1 -2680
RPS26 577
GEMIN2 750
DDX20 3136
GEMIN8 3434



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
779
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 1.22e-32
s.dist -0.644
p.adjustANOVA 1.28e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
UPF1 -9170
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
MAGOH -8779
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
UPF1 -9170
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
MAGOH -8779
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
SMG7 -8611
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
UPF3B -8403
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
SMG1 -8267
UPF2 -8225
PNRC2 -8209
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
CASC3 -7613
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
PPP2CA -6239
RPS5 -6187
RPLP1 -6159
DCP1A -6158
RPL27A -5778
RPL36A -5540
NCBP1 -5334
GSPT1 -5112
RPS3 -4984
RPS18 -4906
SMG5 -4419
RPL23A -4282
RBM8A -3948
SMG6 -3927
ETF1 -3370
RNPS1 -3368
RPS27L -3238
UPF3A -3033
RPL12 -3022
PPP2R2A -2700
EIF4A3 -2560
RPL14 -2377
RPL3L -2329
GSPT2 -1860
PPP2R1A -1738
EIF4G1 -1413
PABPC1 -423
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
SMG9 848
NCBP2 2415
RPL26L1 2574
RPL3 3020
SMG8 4077
MAGOHB 5294



Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
781
set Nonsense-Mediated Decay (NMD)
setSize 114
pANOVA 1.22e-32
s.dist -0.644
p.adjustANOVA 1.28e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
UPF1 -9170
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
MAGOH -8779
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
UPF1 -9170
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
MAGOH -8779
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
SMG7 -8611
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
UPF3B -8403
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
SMG1 -8267
UPF2 -8225
PNRC2 -8209
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
CASC3 -7613
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
PPP2CA -6239
RPS5 -6187
RPLP1 -6159
DCP1A -6158
RPL27A -5778
RPL36A -5540
NCBP1 -5334
GSPT1 -5112
RPS3 -4984
RPS18 -4906
SMG5 -4419
RPL23A -4282
RBM8A -3948
SMG6 -3927
ETF1 -3370
RNPS1 -3368
RPS27L -3238
UPF3A -3033
RPL12 -3022
PPP2R2A -2700
EIF4A3 -2560
RPL14 -2377
RPL3L -2329
GSPT2 -1860
PPP2R1A -1738
EIF4G1 -1413
PABPC1 -423
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
SMG9 848
NCBP2 2415
RPL26L1 2574
RPL3 3020
SMG8 4077
MAGOHB 5294



Selenoamino acid metabolism

Selenoamino acid metabolism
1137
set Selenoamino acid metabolism
setSize 114
pANOVA 8.23e-32
s.dist -0.636
p.adjustANOVA 6.56e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
AIMP1 -9145
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
DARS1 -8824
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
AIMP1 -9145
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
DARS1 -8824
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
LARS1 -8512
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
RARS1 -8023
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EPRS1 -7904
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
SEPHS2 -7380
RPS4X -7375
RPS7 -7364
RPL10A -7319
SECISBP2 -7297
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
MARS1 -7121
RPS13 -7092
RPS19 -6727
RPL17 -6676
RPS14 -6574
CTH -6517
NNMT -6386
RPS5 -6187
RPLP1 -6159
RPL27A -5778
RPL36A -5540
IARS1 -5019
RPS3 -4984
RPS18 -4906
AIMP2 -4881
RPL23A -4282
QARS1 -3846
SARS1 -3598
EEFSEC -3449
KARS1 -3401
AHCY -3361
RPS27L -3238
RPL12 -3022
PSTK -2403
RPL14 -2377
RPL3L -2329
GSR -1959
PAPSS2 -1734
SCLY -1647
SEPSECS -1617
HNMT -1539
TXNRD1 -331
RPLP0 -196
RPL39L -143
RPS26 577
RPL22L1 602
RPL26L1 2574
INMT 2667
RPL3 3020
EEF1E1 3162
PAPSS1 3657
CBS 4235



SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1118
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 2.59e-30
s.dist -0.628
p.adjustANOVA 1.58e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
SRP14 -8598
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
SSR3 -8474
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
SRPRA -7569
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
SEC11A -7378
RPS4X -7375
RPS7 -7364
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
SRP68 -7027
RPS19 -6727
RPL17 -6676
RPS14 -6574
RPS5 -6187
RPLP1 -6159
SRP9 -6031
SEC61A2 -5807
RPL27A -5778
RPL36A -5540
SEC61G -5225
RPS3 -4984
RPS18 -4906
SPCS3 -4843
SSR2 -4317
DDOST -4291
RPL23A -4282
SRP72 -3622
SPCS2 -3566
RPS27L -3238
SEC61B -3133
RPL12 -3022
RPN1 -2564
RPL14 -2377
RPL3L -2329
SEC11C -1673
SRPRB -1181
SEC61A1 -1010
TRAM1 -864
RPN2 -646
SSR1 -282
RPLP0 -196
RPL39L -143
SRP54 -5
RPS26 577
RPL22L1 602
SPCS1 2080
RPL26L1 2574
RPL3 3020
SSR4 3336
SRP19 5993



Mitophagy

Mitophagy
708
set Mitophagy
setSize 28
pANOVA 1.5e-08
s.dist -0.618
p.adjustANOVA 2.53e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATG12 -9158
TOMM6 -8911
CSNK2A2 -8671
MAP1LC3A -8317
TOMM7 -8063
UBA52 -8015
TOMM5 -7985
ULK1 -7767
MFN1 -7734
TOMM22 -7514
ATG5 -7494
TOMM40 -7344
RPS27A -7158
CSNK2B -7151
TOMM20 -7042
TOMM70 -6875
CSNK2A1 -6826
SQSTM1 -6468
UBB -5814
UBC -4857

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATG12 -9158
TOMM6 -8911
CSNK2A2 -8671
MAP1LC3A -8317
TOMM7 -8063
UBA52 -8015
TOMM5 -7985
ULK1 -7767
MFN1 -7734
TOMM22 -7514
ATG5 -7494
TOMM40 -7344
RPS27A -7158
CSNK2B -7151
TOMM20 -7042
TOMM70 -6875
CSNK2A1 -6826
SQSTM1 -6468
UBB -5814
UBC -4857
FUNDC1 -4734
PINK1 -4645
MTERF3 -4593
MFN2 -4404
VDAC1 -3459
MAP1LC3B -2392
PGAM5 514
SRC 2567



Common Pathway of Fibrin Clot Formation

Common Pathway of Fibrin Clot Formation
211
set Common Pathway of Fibrin Clot Formation
setSize 11
pANOVA 0.000486
s.dist 0.607
p.adjustANOVA 0.00266



Top enriched genes

Top 20 genes
GeneID Gene Rank
F13A1 6621
SERPINE2 6504
PF4 6150
F2R 5807
F5 5478
F10 5355
THBD 4047
PROS1 3322
PROCR 3157
SERPINA5 2655
F8 -4842

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F13A1 6621
SERPINE2 6504
PF4 6150
F2R 5807
F5 5478
F10 5355
THBD 4047
PROS1 3322
PROCR 3157
SERPINA5 2655
F8 -4842



Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
407
set Formation of ATP by chemiosmotic coupling
setSize 16
pANOVA 3.99e-05
s.dist -0.593
p.adjustANOVA 0.000301



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5F1E -8877
ATP5ME -8728
ATP5MG -8231
ATP5MF -7330
ATP5PD -7238
ATP5PB -6099
ATP5PO -5955
ATP5MC3 -5706
ATP5MC1 -5616
ATP5PF -5598
ATP5F1D -5435
ATP5MC2 -4894
ATP5F1A -4610
ATP5F1B -3894
ATP5F1C -3741
DMAC2L -2145

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5F1E -8877
ATP5ME -8728
ATP5MG -8231
ATP5MF -7330
ATP5PD -7238
ATP5PB -6099
ATP5PO -5955
ATP5MC3 -5706
ATP5MC1 -5616
ATP5PF -5598
ATP5F1D -5435
ATP5MC2 -4894
ATP5F1A -4610
ATP5F1B -3894
ATP5F1C -3741
DMAC2L -2145



Regulation of FOXO transcriptional activity by acetylation

Regulation of FOXO transcriptional activity by acetylation
1018
set Regulation of FOXO transcriptional activity by acetylation
setSize 10
pANOVA 0.00117
s.dist -0.593
p.adjustANOVA 0.00558



Top enriched genes

Top 20 genes
GeneID Gene Rank
EP300 -9148
SIRT1 -9093
FOXO3 -8776
KAT2B -7840
FOXO1 -7526
CREBBP -5698
TXNIP -4759
SIRT3 -4550
FOXO4 -4161
TXN 2767

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EP300 -9148
SIRT1 -9093
FOXO3 -8776
KAT2B -7840
FOXO1 -7526
CREBBP -5698
TXNIP -4759
SIRT3 -4550
FOXO4 -4161
TXN 2767



Olfactory Signaling Pathway

Olfactory Signaling Pathway
803
set Olfactory Signaling Pathway
setSize 29
pANOVA 3.34e-08
s.dist 0.592
p.adjustANOVA 5.26e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR10G3 7119
ADCY3 6928
OR1D2 6907
OR52K1 6891
OR4D9 6523
OR5AN1 6519
OR6Y1 6248
OR2AT4 6247
OR6C75 6168
OR5A2 6089
OR2M3 5964
OR51E1 5679
OR7C1 5354
OR56A1 5226
OR14J1 5107
OR5AU1 4763
OR5AS1 4493
OR5A1 4272
REEP1 4206
EBF1 4030

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR10G3 7119
ADCY3 6928
OR1D2 6907
OR52K1 6891
OR4D9 6523
OR5AN1 6519
OR6Y1 6248
OR2AT4 6247
OR6C75 6168
OR5A2 6089
OR2M3 5964
OR51E1 5679
OR7C1 5354
OR56A1 5226
OR14J1 5107
OR5AU1 4763
OR5AS1 4493
OR5A1 4272
REEP1 4206
EBF1 4030
OR8A1 3804
OR2V2 3667
OR1I1 3257
GNB1 1364
LDB1 -1450
OR7D2 -1737
ANO2 -3154
OR10H5 -3722
GNAL -3836



Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
559
set Influenza Viral RNA Transcription and Replication
setSize 135
pANOVA 4.32e-30
s.dist -0.568
p.adjustANOVA 2.53e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
HSP90AA1 -8943
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
HSP90AA1 -8943
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RANBP2 -8628
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
GTF2F1 -8540
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
POLR2F -8470
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
POLR2L -8103
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
NUP98 -7680
RPL36AL -7677
RPS9 -7651
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
GTF2F2 -7325
RPL10A -7319
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
NUP54 -7060
NUP58 -6798
NUP160 -6761
RPS19 -6727
RPL17 -6676
RPS14 -6574
SEC13 -6317
NUP37 -6292
RPS5 -6187
RPLP1 -6159
RPL27A -5778
NUP133 -5771
NUP153 -5691
NUP50 -5632
RPL36A -5540
NUP210 -5396
POLR2I -5309
POLR2B -5288
IPO5 -5262
NUP188 -5218
NUP42 -5201
PARP1 -5170
NUP205 -5042
RPS3 -4984
RPS18 -4906
POLR2A -4758
RPL23A -4282
NUP93 -4260
RAE1 -3893
POLR2C -3742
GRSF1 -3549
RPS27L -3238
RPL12 -3022
NUP62 -2956
DNAJC3 -2943
POLR2J -2719
TPR -2493
RPL14 -2377
POM121C -2353
RPL3L -2329
POM121 -863
NUP155 -830
POLR2K -326
POLR2E -285
NUP107 -257
NUP35 -211
RPLP0 -196
RPL39L -143
POLR2G 121
RPS26 577
RPL22L1 602
NUP88 790
NUP214 985
SEH1L 1613
RPL26L1 2574
AAAS 2639
POLR2D 2746
RPL3 3020
NUP43 4730
POLR2H 5035
NUP85 5357
NDC1 6027



Cellular response to starvation

Cellular response to starvation
181
set Cellular response to starvation
setSize 148
pANOVA 2.33e-31
s.dist -0.554
p.adjustANOVA 1.55e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
RPSA -9069
RRAGB -9059
KPTN -9057
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
LAMTOR1 -8803
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
EIF2S3 -9153
RPSA -9069
RRAGB -9059
KPTN -9057
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
LAMTOR1 -8803
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
RRAGA -8372
RPL35A -8364
FNIP1 -8332
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
DDIT3 -8037
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
EIF2AK4 -7745
RPL23 -7726
WDR24 -7682
RPL36AL -7677
RPS9 -7651
BMT2 -7650
ATP6V0E1 -7592
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
RPL10A -7319
LAMTOR3 -7300
ATP6V1G1 -7278
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
LAMTOR4 -7197
RPS28 -7167
RPS27A -7158
RPS2 -7146
SESN1 -7144
RPS13 -7092
ATF4 -6991
ATF2 -6807
RPS19 -6727
RPL17 -6676
RPS14 -6574
ATP6V0C -6499
MIOS -6437
SEC13 -6317
RPS5 -6187
RPLP1 -6159
EIF2S2 -5971
GCN1 -5884
MTOR -5874
RPL27A -5778
LAMTOR5 -5664
MLST8 -5640
RHEB -5629
RPL36A -5540
ITFG2 -5516
ATP6V1C1 -5445
LAMTOR2 -5357
ATP6V1B2 -5157
ATP6V0E2 -5021
RPS3 -4984
RPS18 -4906
RPL23A -4282
NPRL3 -4016
FLCN -3406
ATP6V0D1 -3311
RPS27L -3238
RPL12 -3022
NPRL2 -2954
RRAGD -2891
ATP6V1E2 -2563
ATP6V1D -2542
RPL14 -2377
RPL3L -2329
CEBPB -1995
RRAGC -1559
ATP6V0B -1434
WDR59 -1293
CEBPG -856
ATP6V1H -643
ATP6V1A -601
ATP6V1E1 -442
RPLP0 -196
RPL39L -143
SESN2 -19
ATP6V1F 568
RPS26 577
RPL22L1 602
FNIP2 717
SLC38A9 727
SEH1L 1613
SH3BP4 2277
IMPACT 2367
DEPDC5 2471
RPTOR 2481
ATP6V1C2 2495
RPL26L1 2574
RPL3 3020
SZT2 3073
TRIB3 3220
ATF3 5044
TCIRG1 5752
ASNS 6691



Translation

Translation
1368
set Translation
setSize 292
pANOVA 1.17e-59
s.dist -0.553
p.adjustANOVA 8.54e-57



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
MRPL54 -9175
EIF2S3 -9153
AIMP1 -9145
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
MRPL48 -8950
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
MRPL22 -8839
RPL19 -8835
EEF1D -8834
DARS1 -8824

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
MRPL54 -9175
EIF2S3 -9153
AIMP1 -9145
EIF3E -9125
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
MRPL48 -8950
RPL35 -8896
RPS29 -8889
EIF3A -8865
RPL5 -8844
MRPL22 -8839
RPL19 -8835
EEF1D -8834
DARS1 -8824
EIF3I -8804
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
EIF3H -8715
MRPS30 -8683
EIF4B -8662
RPL26 -8660
RPS24 -8637
YARS2 -8617
RPS3A -8610
RPL21 -8604
RPL22 -8602
SRP14 -8598
RPL38 -8575
EIF3C -8561
RPL30 -8551
PPA2 -8547
RPS15 -8544
MRPS5 -8542
RPS6 -8538
LARS1 -8512
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
SSR3 -8474
MRPL34 -8468
RPL36 -8458
MRPS2 -8420
EIF3F -8392
RPL35A -8364
PPA1 -8339
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
MRPL13 -8240
EIF3D -8215
RPL37A -8193
RPL29 -8173
CARS2 -8147
MRPL9 -8107
MRPS17 -8104
RPL11 -8081
IARS2 -8066
MRPS36 -8062
EEF1B2 -8057
HARS2 -8046
RPL24 -8040
RARS1 -8023
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
EIF3G -7905
EPRS1 -7904
MTRF1L -7895
RPL41 -7858
RPS25 -7825
RPS17 -7816
MRPL28 -7802
RPL13A -7782
RPS12 -7764
RPL6 -7750
CHCHD1 -7733
RPL23 -7726
WARS2 -7683
RPL36AL -7677
RPS9 -7651
SRPRA -7569
TUFM -7564
MRPS34 -7562
RPLP2 -7545
RPS4Y1 -7535
MRPL30 -7505
MRPL51 -7503
EIF3M -7495
EIF1AX -7473
NARS1 -7454
RPS8 -7427
SEC11A -7378
MRPL19 -7376
RPS4X -7375
RPS7 -7364
MRPL32 -7346
MRPL47 -7343
RPL10A -7319
MRPL27 -7283
RPL28 -7270
RPL18 -7257
EIF2S1 -7203
RPS28 -7167
MRPL12 -7164
RPS27A -7158
GARS1 -7155
RPS2 -7146
EIF5B -7134
EIF4A2 -7132
MARS1 -7121
RPS13 -7092
MRPS27 -7037
GADD45GIP1 -7031
SRP68 -7027
MRPL16 -6987
MRPL18 -6934
MRPL58 -6870
MRPL4 -6846
MRPL52 -6792
RPS19 -6727
RPL17 -6676
MRPL57 -6665
MRPL46 -6656
AARS1 -6599
RPS14 -6574
EEF2 -6569
MRPS21 -6507
MRPL42 -6451
MRPL1 -6405
EEF1G -6397
TARS1 -6379
EIF3B -6339
MRPS25 -6310
MRPL11 -6283
DARS2 -6210
MRPS14 -6190
RPS5 -6187
RPLP1 -6159
MRPS15 -6153
EIF2B5 -6139
DAP3 -6131
MRRF -6096
EIF5 -6083
SRP9 -6031
EIF2S2 -5971
MRPS9 -5883
EIF3K -5872
MRPL41 -5867
SEC61A2 -5807
EIF3J -5790
RPL27A -5778
MRPL21 -5747
MRPL24 -5724
MTIF3 -5720
MRPL45 -5609
MTIF2 -5550
PTCD3 -5547
RPL36A -5540
MRPS16 -5488
MRPL33 -5487
MRPL38 -5462
MRPL37 -5453
MRPL15 -5432
MRPL44 -5420
EIF2B3 -5301
MRPS26 -5293
EIF2B4 -5281
SEC61G -5225
GSPT1 -5112
RARS2 -5110
MRPS18B -5089
GFM1 -5050
IARS1 -5019
FARSA -5005
RPS3 -4984
MTFMT -4965
APEH -4956
RPS18 -4906
AIMP2 -4881
MRPL17 -4871
SPCS3 -4843
MRPL2 -4827
LARS2 -4826
MRPL39 -4731
OXA1L -4723
TRMT112 -4666
MRPS22 -4603
MRPS11 -4578
EIF4H -4542
EIF4EBP1 -4509
EIF4E -4481
YARS1 -4345
MRPL53 -4339
MRPS18A -4326
SSR2 -4317
DDOST -4291
RPL23A -4282
MRPS35 -4276
AURKAIP1 -4245
MARS2 -4181
TARS2 -4097
MRPL35 -4049
MRPS33 -4027
MRPL20 -3969
MRPS10 -3918
GFM2 -3914
QARS1 -3846
MRPL55 -3816
TSFM -3735
MRPS12 -3716
SRP72 -3622
SARS1 -3598
SPCS2 -3566
KARS1 -3401
ETF1 -3370
RPS27L -3238
CARS1 -3231
MRPS7 -3161
MRPS24 -3150
SEC61B -3133
MRPL49 -3106
MRPL10 -3084
RPL12 -3022
N6AMT1 -2920
MRPL36 -2733
SARS2 -2692
FARSB -2570
RPN1 -2564
MRPS23 -2539
ERAL1 -2519
MRPS28 -2436
RPL14 -2377
RPL3L -2329
MRPL40 -2188
MRPL43 -2122
MRPL50 -2063
NARS2 -1917
GSPT2 -1860
SEC11C -1673
EIF4G1 -1413
MRPL14 -1341
EEF1A2 -1314
EIF3L -1209
SRPRB -1181
MRPS18C -1155
FARS2 -1137
SEC61A1 -1010
TRAM1 -864
RPN2 -646
EARS2 -568
MRPL23 -454
PABPC1 -423
SSR1 -282
RPLP0 -196
RPL39L -143
WARS1 -105
SRP54 -5
AARS2 -2
MRPL3 494
RPS26 577
RPL22L1 602
PARS2 655
VARS1 831
EIF2B2 1401
MRPS31 1430
EIF2B1 1899
SPCS1 2080
HARS1 2405
RPL26L1 2574
EEF1A1 2882
RPL3 3020
EEF1E1 3162
SSR4 3336
EIF4A1 4037
EEF1A1P5 4167
MRPS6 4951
VARS2 5425
SRP19 5993



Cristae formation

Cristae formation
230
set Cristae formation
setSize 29
pANOVA 4.03e-07
s.dist -0.544
p.adjustANOVA 5.61e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATP5F1E -8877
ATP5ME -8728
ATP5MG -8231
ATP5MF -7330
ATP5PD -7238
DNAJC11 -7230
HSPA9 -6518
MICOS10 -6516
MICOS13 -6415
APOOL -6358
ATP5PB -6099
SAMM50 -6028
ATP5PO -5955
ATP5MC3 -5706
ATP5MC1 -5616
ATP5PF -5598
ATP5F1D -5435
MTX1 -5425
CHCHD6 -5326
ATP5MC2 -4894

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATP5F1E -8877
ATP5ME -8728
ATP5MG -8231
ATP5MF -7330
ATP5PD -7238
DNAJC11 -7230
HSPA9 -6518
MICOS10 -6516
MICOS13 -6415
APOOL -6358
ATP5PB -6099
SAMM50 -6028
ATP5PO -5955
ATP5MC3 -5706
ATP5MC1 -5616
ATP5PF -5598
ATP5F1D -5435
MTX1 -5425
CHCHD6 -5326
ATP5MC2 -4894
CHCHD3 -4867
ATP5F1A -4610
ATP5F1B -3894
MTX2 -3782
ATP5F1C -3741
APOO -3321
IMMT -2166
DMAC2L -2145
TMEM11 -562



Complex I biogenesis

Complex I biogenesis
214
set Complex I biogenesis
setSize 51
pANOVA 2.08e-11
s.dist -0.542
p.adjustANOVA 4.68e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDUFA3 -8846
NDUFA13 -8067
NDUFB1 -8003
NDUFS5 -7980
ACAD9 -7909
NDUFA1 -7698
NDUFA5 -7269
NDUFB6 -7222
ECSIT -7191
NDUFAF3 -7123
NDUFB7 -7112
NDUFS6 -7098
NDUFAF7 -7081
NDUFB3 -7055
NDUFA2 -6890
NUBPL -6772
NDUFAF2 -6732
NDUFB11 -6297
NDUFS4 -6030
TMEM126B -6018

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDUFA3 -8846
NDUFA13 -8067
NDUFB1 -8003
NDUFS5 -7980
ACAD9 -7909
NDUFA1 -7698
NDUFA5 -7269
NDUFB6 -7222
ECSIT -7191
NDUFAF3 -7123
NDUFB7 -7112
NDUFS6 -7098
NDUFAF7 -7081
NDUFB3 -7055
NDUFA2 -6890
NUBPL -6772
NDUFAF2 -6732
NDUFB11 -6297
NDUFS4 -6030
TMEM126B -6018
NDUFV1 -5939
NDUFAF4 -5911
NDUFB4 -5862
NDUFAB1 -5813
NDUFA9 -5531
NDUFS8 -5514
NDUFB2 -5440
NDUFB8 -5236
NDUFS3 -5200
NDUFA6 -5145
TIMMDC1 -5100
NDUFA8 -5082
NDUFA12 -5058
NDUFC2 -5013
NDUFB5 -4794
NDUFA11 -4742
NDUFS7 -4717
NDUFA10 -4614
NDUFB10 -4599
NDUFV2 -4583
NDUFV3 -4416
NDUFAF5 -3963
NDUFC1 -3785
TMEM186 -3467
COA1 -3444
NDUFS1 -3379
NDUFS2 -3012
NDUFB9 -2423
NDUFAF6 -1592
NDUFA7 -1474
NDUFAF1 1210



Respiratory electron transport

Respiratory electron transport
1076
set Respiratory electron transport
setSize 93
pANOVA 3.66e-19
s.dist -0.537
p.adjustANOVA 1.22e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
COX7A2L -8906
NDUFA3 -8846
ETFDH -8196
NDUFA13 -8067
UQCRB -8044
NDUFB1 -8003
NDUFS5 -7980
ACAD9 -7909
NDUFA1 -7698
COX19 -7513
NDUFA5 -7269
NDUFB6 -7222
UQCRH -7220
ECSIT -7191
SDHD -7137
NDUFAF3 -7123
NDUFB7 -7112
NDUFS6 -7098
NDUFAF7 -7081
NDUFB3 -7055

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COX7A2L -8906
NDUFA3 -8846
ETFDH -8196
NDUFA13 -8067
UQCRB -8044
NDUFB1 -8003
NDUFS5 -7980
ACAD9 -7909
NDUFA1 -7698
COX19 -7513
NDUFA5 -7269
NDUFB6 -7222
UQCRH -7220
ECSIT -7191
SDHD -7137
NDUFAF3 -7123
NDUFB7 -7112
NDUFS6 -7098
NDUFAF7 -7081
NDUFB3 -7055
COX16 -7034
NDUFA2 -6890
COX4I1 -6885
SCO1 -6863
COX11 -6850
NUBPL -6772
COX7C -6734
NDUFAF2 -6732
COX6B1 -6548
SURF1 -6412
SDHC -6395
CYCS -6361
UQCR11 -6321
NDUFB11 -6297
LRPPRC -6094
COX18 -6055
NDUFS4 -6030
TMEM126B -6018
TACO1 -6011
NDUFV1 -5939
ETFB -5922
NDUFAF4 -5911
NDUFB4 -5862
UQCR10 -5858
NDUFAB1 -5813
SDHB -5717
COX5A -5712
COX5B -5661
NDUFA9 -5531
NDUFS8 -5514
COX7B -5472
NDUFB2 -5440
UQCRQ -5274
NDUFB8 -5236
UQCRFS1 -5204
NDUFS3 -5200
NDUFA6 -5145
CYC1 -5107
TIMMDC1 -5100
NDUFA8 -5082
NDUFA12 -5058
UQCRC2 -5018
NDUFC2 -5013
SDHA -4816
NDUFB5 -4794
NDUFA11 -4742
NDUFS7 -4717
NDUFA10 -4614
NDUFB10 -4599
NDUFV2 -4583
COX8A -4434
NDUFV3 -4416
COX6C -4251
ETFA -4099
NDUFA4 -4050
NDUFAF5 -3963
NDUFC1 -3785
TRAP1 -3690
UQCRC1 -3562
COX14 -3557
TMEM186 -3467
COA1 -3444
NDUFS1 -3379
NDUFS2 -3012
COQ10A -2975
SCO2 -2688
NDUFB9 -2423
NDUFAF6 -1592
NDUFA7 -1474
COX6A1 -390
COQ10B 303
COX20 1152
NDUFAF1 1210



Receptor Mediated Mitophagy

Receptor Mediated Mitophagy
997
set Receptor Mediated Mitophagy
setSize 11
pANOVA 0.00212
s.dist -0.535
p.adjustANOVA 0.00888



Top enriched genes

Top 20 genes
GeneID Gene Rank
ATG12 -9158
CSNK2A2 -8671
MAP1LC3A -8317
ULK1 -7767
ATG5 -7494
CSNK2B -7151
CSNK2A1 -6826
FUNDC1 -4734
MAP1LC3B -2392
PGAM5 514
SRC 2567

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ATG12 -9158
CSNK2A2 -8671
MAP1LC3A -8317
ULK1 -7767
ATG5 -7494
CSNK2B -7151
CSNK2A1 -6826
FUNDC1 -4734
MAP1LC3B -2392
PGAM5 514
SRC 2567



Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1077
set Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
setSize 113
pANOVA 1.39e-22
s.dist -0.532
p.adjustANOVA 5.37e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
COX7A2L -8906
ATP5F1E -8877
NDUFA3 -8846
ATP5ME -8728
ATP5MG -8231
ETFDH -8196
NDUFA13 -8067
UQCRB -8044
NDUFB1 -8003
NDUFS5 -7980
ACAD9 -7909
NDUFA1 -7698
COX19 -7513
ATP5MF -7330
NDUFA5 -7269
ATP5PD -7238
NDUFB6 -7222
UQCRH -7220
ECSIT -7191
SDHD -7137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COX7A2L -8906
ATP5F1E -8877
NDUFA3 -8846
ATP5ME -8728
ATP5MG -8231
ETFDH -8196
NDUFA13 -8067
UQCRB -8044
NDUFB1 -8003
NDUFS5 -7980
ACAD9 -7909
NDUFA1 -7698
COX19 -7513
ATP5MF -7330
NDUFA5 -7269
ATP5PD -7238
NDUFB6 -7222
UQCRH -7220
ECSIT -7191
SDHD -7137
NDUFAF3 -7123
NDUFB7 -7112
NDUFS6 -7098
NDUFAF7 -7081
NDUFB3 -7055
COX16 -7034
NDUFA2 -6890
COX4I1 -6885
SCO1 -6863
COX11 -6850
NUBPL -6772
COX7C -6734
NDUFAF2 -6732
SLC25A27 -6590
COX6B1 -6548
SURF1 -6412
SDHC -6395
CYCS -6361
UQCR11 -6321
NDUFB11 -6297
ATP5PB -6099
LRPPRC -6094
COX18 -6055
NDUFS4 -6030
TMEM126B -6018
TACO1 -6011
ATP5PO -5955
NDUFV1 -5939
ETFB -5922
NDUFAF4 -5911
NDUFB4 -5862
UQCR10 -5858
NDUFAB1 -5813
SDHB -5717
COX5A -5712
ATP5MC3 -5706
COX5B -5661
ATP5MC1 -5616
ATP5PF -5598
NDUFA9 -5531
NDUFS8 -5514
COX7B -5472
NDUFB2 -5440
ATP5F1D -5435
UQCRQ -5274
NDUFB8 -5236
UQCRFS1 -5204
NDUFS3 -5200
NDUFA6 -5145
CYC1 -5107
TIMMDC1 -5100
NDUFA8 -5082
NDUFA12 -5058
UQCRC2 -5018
NDUFC2 -5013
ATP5MC2 -4894
SDHA -4816
NDUFB5 -4794
NDUFA11 -4742
NDUFS7 -4717
NDUFA10 -4614
ATP5F1A -4610
NDUFB10 -4599
NDUFV2 -4583
COX8A -4434
NDUFV3 -4416
COX6C -4251
ETFA -4099
NDUFA4 -4050
NDUFAF5 -3963
ATP5F1B -3894
NDUFC1 -3785
ATP5F1C -3741
TRAP1 -3690
UQCRC1 -3562
COX14 -3557
TMEM186 -3467
COA1 -3444
NDUFS1 -3379
SLC25A14 -3176
NDUFS2 -3012
COQ10A -2975
SCO2 -2688
NDUFB9 -2423
DMAC2L -2145
NDUFAF6 -1592
NDUFA7 -1474
UCP2 -701
COX6A1 -390
COQ10B 303
COX20 1152
NDUFAF1 1210
UCP3 1325



Mitochondrial translation

Mitochondrial translation
704
set Mitochondrial translation
setSize 94
pANOVA 5.59e-19
s.dist -0.531
p.adjustANOVA 1.82e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MTRF1L -7895
MRPL28 -7802
CHCHD1 -7733
TUFM -7564
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MTRF1L -7895
MRPL28 -7802
CHCHD1 -7733
TUFM -7564
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343
MRPL27 -7283
MRPL12 -7164
MRPS27 -7037
GADD45GIP1 -7031
MRPL16 -6987
MRPL18 -6934
MRPL58 -6870
MRPL4 -6846
MRPL52 -6792
MRPL57 -6665
MRPL46 -6656
MRPS21 -6507
MRPL42 -6451
MRPL1 -6405
MRPS25 -6310
MRPL11 -6283
MRPS14 -6190
MRPS15 -6153
DAP3 -6131
MRRF -6096
MRPS9 -5883
MRPL41 -5867
MRPL21 -5747
MRPL24 -5724
MTIF3 -5720
MRPL45 -5609
MTIF2 -5550
PTCD3 -5547
MRPS16 -5488
MRPL33 -5487
MRPL38 -5462
MRPL37 -5453
MRPL15 -5432
MRPL44 -5420
MRPS26 -5293
MRPS18B -5089
GFM1 -5050
MTFMT -4965
MRPL17 -4871
MRPL2 -4827
MRPL39 -4731
OXA1L -4723
MRPS22 -4603
MRPS11 -4578
MRPL53 -4339
MRPS18A -4326
MRPS35 -4276
AURKAIP1 -4245
MRPL35 -4049
MRPS33 -4027
MRPL20 -3969
MRPS10 -3918
GFM2 -3914
MRPL55 -3816
TSFM -3735
MRPS12 -3716
MRPS7 -3161
MRPS24 -3150
MRPL49 -3106
MRPL10 -3084
MRPL36 -2733
MRPS23 -2539
ERAL1 -2519
MRPS28 -2436
MRPL40 -2188
MRPL43 -2122
MRPL50 -2063
MRPL14 -1341
MRPS18C -1155
MRPL23 -454
MRPL3 494
MRPS31 1430
MRPS6 4951



Mitochondrial translation termination

Mitochondrial translation termination
707
set Mitochondrial translation termination
setSize 88
pANOVA 8.14e-18
s.dist -0.53
p.adjustANOVA 2.53e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MTRF1L -7895
MRPL28 -7802
CHCHD1 -7733
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MTRF1L -7895
MRPL28 -7802
CHCHD1 -7733
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343
MRPL27 -7283
MRPL12 -7164
MRPS27 -7037
GADD45GIP1 -7031
MRPL16 -6987
MRPL18 -6934
MRPL58 -6870
MRPL4 -6846
MRPL52 -6792
MRPL57 -6665
MRPL46 -6656
MRPS21 -6507
MRPL42 -6451
MRPL1 -6405
MRPS25 -6310
MRPL11 -6283
MRPS14 -6190
MRPS15 -6153
DAP3 -6131
MRRF -6096
MRPS9 -5883
MRPL41 -5867
MRPL21 -5747
MRPL24 -5724
MRPL45 -5609
PTCD3 -5547
MRPS16 -5488
MRPL33 -5487
MRPL38 -5462
MRPL37 -5453
MRPL15 -5432
MRPL44 -5420
MRPS26 -5293
MRPS18B -5089
MRPL17 -4871
MRPL2 -4827
MRPL39 -4731
OXA1L -4723
MRPS22 -4603
MRPS11 -4578
MRPL53 -4339
MRPS18A -4326
MRPS35 -4276
AURKAIP1 -4245
MRPL35 -4049
MRPS33 -4027
MRPL20 -3969
MRPS10 -3918
GFM2 -3914
MRPL55 -3816
MRPS12 -3716
MRPS7 -3161
MRPS24 -3150
MRPL49 -3106
MRPL10 -3084
MRPL36 -2733
MRPS23 -2539
ERAL1 -2519
MRPS28 -2436
MRPL40 -2188
MRPL43 -2122
MRPL50 -2063
MRPL14 -1341
MRPS18C -1155
MRPL23 -454
MRPL3 494
MRPS31 1430
MRPS6 4951



Mitochondrial translation elongation

Mitochondrial translation elongation
705
set Mitochondrial translation elongation
setSize 88
pANOVA 1.1e-17
s.dist -0.528
p.adjustANOVA 3.36e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MRPL28 -7802
CHCHD1 -7733
TUFM -7564
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MRPL28 -7802
CHCHD1 -7733
TUFM -7564
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343
MRPL27 -7283
MRPL12 -7164
MRPS27 -7037
GADD45GIP1 -7031
MRPL16 -6987
MRPL18 -6934
MRPL58 -6870
MRPL4 -6846
MRPL52 -6792
MRPL57 -6665
MRPL46 -6656
MRPS21 -6507
MRPL42 -6451
MRPL1 -6405
MRPS25 -6310
MRPL11 -6283
MRPS14 -6190
MRPS15 -6153
DAP3 -6131
MRPS9 -5883
MRPL41 -5867
MRPL21 -5747
MRPL24 -5724
MRPL45 -5609
PTCD3 -5547
MRPS16 -5488
MRPL33 -5487
MRPL38 -5462
MRPL37 -5453
MRPL15 -5432
MRPL44 -5420
MRPS26 -5293
MRPS18B -5089
GFM1 -5050
MRPL17 -4871
MRPL2 -4827
MRPL39 -4731
OXA1L -4723
MRPS22 -4603
MRPS11 -4578
MRPL53 -4339
MRPS18A -4326
MRPS35 -4276
AURKAIP1 -4245
MRPL35 -4049
MRPS33 -4027
MRPL20 -3969
MRPS10 -3918
MRPL55 -3816
TSFM -3735
MRPS12 -3716
MRPS7 -3161
MRPS24 -3150
MRPL49 -3106
MRPL10 -3084
MRPL36 -2733
MRPS23 -2539
ERAL1 -2519
MRPS28 -2436
MRPL40 -2188
MRPL43 -2122
MRPL50 -2063
MRPL14 -1341
MRPS18C -1155
MRPL23 -454
MRPL3 494
MRPS31 1430
MRPS6 4951



Mitochondrial translation initiation

Mitochondrial translation initiation
706
set Mitochondrial translation initiation
setSize 88
pANOVA 1.13e-17
s.dist -0.528
p.adjustANOVA 3.37e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MRPL28 -7802
CHCHD1 -7733
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343
MRPL27 -7283

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MRPL54 -9175
MRPL48 -8950
MRPL22 -8839
MRPS30 -8683
MRPS5 -8542
MRPL34 -8468
MRPS2 -8420
MRPL13 -8240
MRPL9 -8107
MRPS17 -8104
MRPS36 -8062
MRPL28 -7802
CHCHD1 -7733
MRPS34 -7562
MRPL30 -7505
MRPL51 -7503
MRPL19 -7376
MRPL32 -7346
MRPL47 -7343
MRPL27 -7283
MRPL12 -7164
MRPS27 -7037
GADD45GIP1 -7031
MRPL16 -6987
MRPL18 -6934
MRPL58 -6870
MRPL4 -6846
MRPL52 -6792
MRPL57 -6665
MRPL46 -6656
MRPS21 -6507
MRPL42 -6451
MRPL1 -6405
MRPS25 -6310
MRPL11 -6283
MRPS14 -6190
MRPS15 -6153
DAP3 -6131
MRPS9 -5883
MRPL41 -5867
MRPL21 -5747
MRPL24 -5724
MTIF3 -5720
MRPL45 -5609
MTIF2 -5550
PTCD3 -5547
MRPS16 -5488
MRPL33 -5487
MRPL38 -5462
MRPL37 -5453
MRPL15 -5432
MRPL44 -5420
MRPS26 -5293
MRPS18B -5089
MTFMT -4965
MRPL17 -4871
MRPL2 -4827
MRPL39 -4731
OXA1L -4723
MRPS22 -4603
MRPS11 -4578
MRPL53 -4339
MRPS18A -4326
MRPS35 -4276
AURKAIP1 -4245
MRPL35 -4049
MRPS33 -4027
MRPL20 -3969
MRPS10 -3918
MRPL55 -3816
MRPS12 -3716
MRPS7 -3161
MRPS24 -3150
MRPL49 -3106
MRPL10 -3084
MRPL36 -2733
MRPS23 -2539
ERAL1 -2519
MRPS28 -2436
MRPL40 -2188
MRPL43 -2122
MRPL50 -2063
MRPL14 -1341
MRPS18C -1155
MRPL23 -454
MRPL3 494
MRPS31 1430
MRPS6 4951



Influenza Infection

Influenza Infection
558
set Influenza Infection
setSize 154
pANOVA 3.36e-29
s.dist -0.523
p.adjustANOVA 1.76e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
HSP90AA1 -8943
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
HSP90AA1 -8943
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RANBP2 -8628
RPS3A -8610
RPL21 -8604
RPL22 -8602
RPL38 -8575
RPL30 -8551
RPS15 -8544
GTF2F1 -8540
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
POLR2F -8470
RPL36 -8458
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
KPNB1 -8234
RPL37A -8193
RPL29 -8173
POLR2L -8103
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
NUP98 -7680
RPL36AL -7677
RPS9 -7651
SLC25A6 -7550
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
RPS4X -7375
RPS7 -7364
GTF2F2 -7325
RPL10A -7319
XPO1 -7296
RPL28 -7270
RPL18 -7257
RPS28 -7167
RPS27A -7158
RPS2 -7146
RPS13 -7092
NUP54 -7060
NUP58 -6798
NUP160 -6761
RPS19 -6727
RPL17 -6676
RPS14 -6574
HSPA1A -6509
SEC13 -6317
NUP37 -6292
RPS5 -6187
RPLP1 -6159
RPL27A -5778
NUP133 -5771
NUP153 -5691
NUP50 -5632
RPL36A -5540
NUP210 -5396
POLR2I -5309
POLR2B -5288
IPO5 -5262
ISG15 -5246
NUP188 -5218
NUP42 -5201
PARP1 -5170
NUP205 -5042
RPS3 -4984
RPS18 -4906
POLR2A -4758
CLTA -4620
RPL23A -4282
NUP93 -4260
CALR -3922
RAE1 -3893
RAN -3759
POLR2C -3742
GRSF1 -3549
RPS27L -3238
RPL12 -3022
CLTC -3017
NUP62 -2956
DNAJC3 -2943
POLR2J -2719
TPR -2493
KPNA5 -2443
RPL14 -2377
POM121C -2353
RPL3L -2329
CANX -2175
KPNA1 -1902
KPNA3 -1784
EIF2AK2 -1265
KPNA4 -1222
POM121 -863
NUP155 -830
POLR2K -326
POLR2E -285
NUP107 -257
NUP35 -211
RPLP0 -196
RPL39L -143
POLR2G 121
RPS26 577
RPL22L1 602
NUP88 790
NUP214 985
TGFB1 1202
SEH1L 1613
KPNA2 1909
RPL26L1 2574
AAAS 2639
POLR2D 2746
RPL3 3020
PABPN1 3039
CPSF4 4237
NUP43 4730
POLR2H 5035
NUP85 5357
NDC1 6027



Formation of Fibrin Clot (Clotting Cascade)

Formation of Fibrin Clot (Clotting Cascade)
408
set Formation of Fibrin Clot (Clotting Cascade)
setSize 20
pANOVA 5.36e-05
s.dist 0.522
p.adjustANOVA 0.000394



Top enriched genes

Top 20 genes
GeneID Gene Rank
TFPI 7103
F13A1 6621
SERPINE2 6504
A2M 6271
PF4 6150
F2R 5807
F5 5478
F3 5461
F10 5355
PRCP 5033
GP1BB 4968
THBD 4047
PROS1 3322
VWF 3201
PROCR 3157
SERPINA5 2655
SERPING1 1779
F8 -4842
KLKB1 -5366
C1QBP -6427

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TFPI 7103
F13A1 6621
SERPINE2 6504
A2M 6271
PF4 6150
F2R 5807
F5 5478
F3 5461
F10 5355
PRCP 5033
GP1BB 4968
THBD 4047
PROS1 3322
VWF 3201
PROCR 3157
SERPINA5 2655
SERPING1 1779
F8 -4842
KLKB1 -5366
C1QBP -6427



Branched-chain amino acid catabolism

Branched-chain amino acid catabolism
123
set Branched-chain amino acid catabolism
setSize 21
pANOVA 3.89e-05
s.dist -0.519
p.adjustANOVA 0.000295



Top enriched genes

Top 20 genes
GeneID Gene Rank
BCKDHB -8636
PPM1K -8064
ACAT1 -7523
HIBCH -7345
IVD -7156
BCAT2 -6384
HIBADH -6289
DBT -6233
MCCC1 -5914
ALDH6A1 -5760
DLD -5637
MCCC2 -5416
HSD17B10 -5319
ACAD8 -5066
ECHS1 -4997
BCKDHA -4992
BCKDK -4893
ACADSB -4135
AUH -1884
SLC25A44 -1198

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
BCKDHB -8636
PPM1K -8064
ACAT1 -7523
HIBCH -7345
IVD -7156
BCAT2 -6384
HIBADH -6289
DBT -6233
MCCC1 -5914
ALDH6A1 -5760
DLD -5637
MCCC2 -5416
HSD17B10 -5319
ACAD8 -5066
ECHS1 -4997
BCKDHA -4992
BCKDK -4893
ACADSB -4135
AUH -1884
SLC25A44 -1198
BCAT1 2281



Translation of Replicase and Assembly of the Replication Transcription Complex_9679504

Translation of Replicase and Assembly of the Replication Transcription Complex_9679504
1370
set Translation of Replicase and Assembly of the Replication Transcription Complex_9679504
setSize 12
pANOVA 0.00196
s.dist -0.516
p.adjustANOVA 0.00834



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIK3C3 -8581
CHMP3 -8379
PIK3R4 -7915
CHMP2B -6818
CHMP7 -6760
CHMP2A -6492
CHMP4B -5674
UVRAG -5296
CHMP6 -3052
MAP1LC3B -2392
BECN1 -1741
CHMP4A 120

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIK3C3 -8581
CHMP3 -8379
PIK3R4 -7915
CHMP2B -6818
CHMP7 -6760
CHMP2A -6492
CHMP4B -5674
UVRAG -5296
CHMP6 -3052
MAP1LC3B -2392
BECN1 -1741
CHMP4A 120



Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade
114
set Beta-catenin phosphorylation cascade
setSize 17
pANOVA 0.000242
s.dist -0.514
p.adjustANOVA 0.00146



Top enriched genes

Top 20 genes
GeneID Gene Rank
AXIN1 -9179
AMER1 -8922
FRAT2 -8670
PPP2R5C -8460
APC -7499
CSNK1A1 -6329
PPP2CA -6239
PPP2R5D -6188
FRAT1 -5993
PPP2R5E -5836
PPP2R5B -5648
PPP2CB -4090
GSK3B -3239
CTNNB1 -2957
PPP2R5A -2472
PPP2R1A -1738
PPP2R1B 4557

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AXIN1 -9179
AMER1 -8922
FRAT2 -8670
PPP2R5C -8460
APC -7499
CSNK1A1 -6329
PPP2CA -6239
PPP2R5D -6188
FRAT1 -5993
PPP2R5E -5836
PPP2R5B -5648
PPP2CB -4090
GSK3B -3239
CTNNB1 -2957
PPP2R5A -2472
PPP2R1A -1738
PPP2R1B 4557



Regulation of expression of SLITs and ROBOs

Regulation of expression of SLITs and ROBOs
1051
set Regulation of expression of SLITs and ROBOs
setSize 162
pANOVA 1.86e-29
s.dist -0.513
p.adjustANOVA 1.01e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
MAGOH -8779
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL9 -9193
RPSA -9069
RPL8 -9045
RPS27 -9023
RPL39 -9019
RPL10 -8958
RPS21 -8956
RPL35 -8896
RPS29 -8889
RPL5 -8844
RPL19 -8835
RPS23 -8794
MAGOH -8779
FAU -8778
RPL37 -8774
RPL13 -8760
RPS16 -8752
RPS15A -8723
RPL26 -8660
RPS24 -8637
RPS3A -8610
RPL21 -8604
RPL22 -8602
PSMD9 -8596
RPL38 -8575
RPL30 -8551
RPS15 -8544
RPS6 -8538
RPL18A -8510
RPL32 -8491
RPL7A -8488
RPS10 -8476
RPL36 -8458
UPF3B -8403
RPL35A -8364
RPL27 -8329
RPL34 -8283
RPL4 -8279
RPS11 -8273
UPF2 -8225
RPL37A -8193
RPL29 -8173
RPL11 -8081
RPL24 -8040
UBA52 -8015
RPL15 -7966
RPL31 -7935
RPS20 -7922
RPL7 -7911
RPL41 -7858
RPS25 -7825
RPS17 -7816
RPL13A -7782
RPS12 -7764
RPL6 -7750
RPL23 -7726
RPL36AL -7677
RPS9 -7651
CASC3 -7613
RPLP2 -7545
RPS4Y1 -7535
RPS8 -7427
PSMC2 -7403
RPS4X -7375
RPS7 -7364
RPL10A -7319
PSMB3 -7282
RPL28 -7270
RPL18 -7257
USP33 -7216
ELOB -7170
RPS28 -7167
RPS27A -7158
RPS2 -7146
PSMA3 -7105
RPS13 -7092
PSMB10 -6950
PSMB1 -6768
RPS19 -6727
RPL17 -6676
RPS14 -6574
PSMF1 -6454
PSME3 -6306
RPS5 -6187
RPLP1 -6159
PSMB6 -6137
PSMD3 -5977
UBB -5814
RPL27A -5778
RPL36A -5540
PSMD8 -5400
NCBP1 -5334
PSMA6 -5322
PSMC6 -5268
GSPT1 -5112
PSMC5 -5067
PSMA2 -5031
CUL2 -4996
RPS3 -4984
PSMA7 -4955
RPS18 -4906
UBC -4857
PSMB7 -4777
SEM1 -4750
PSMA4 -4631
PSMD13 -4372
RPL23A -4282
PSMA1 -4199
PSMD6 -4060
RBM8A -3948
PSMD11 -3874
PSMD12 -3731
ELOC -3489
ETF1 -3370
RNPS1 -3368
HOXA2 -3339
RBX1 -3249
RPS27L -3238
PSMC4 -3144
PSMD4 -3131
UPF3A -3033
RPL12 -3022
PSMC3 -2992
PSMB5 -2933
PSMC1 -2895
PSMD7 -2738
EIF4A3 -2560
PSMA5 -2419
RPL14 -2377
RPL3L -2329
GSPT2 -1860
PSME2 -1779
PSME1 -1715
LDB1 -1450
PSME4 -1447
EIF4G1 -1413
ZSWIM8 -1358
PSMD2 -768
PSMD14 -686
PSMB2 -661
ROBO1 -547
PABPC1 -423
PSMD1 -351
RPLP0 -196
RPL39L -143
PSMB4 -124
LHX4 38
DAG1 168
PSMD10 323
RPS26 577
RPL22L1 602
ROBO2 1984
PSMB8 2089
NCBP2 2415
RPL26L1 2574
RPL3 3020
ROBO3 3477
COL4A5 3912
PSMD5 4392
PSMB9 4445
MAGOHB 5294
SLIT2 5948



Laminin interactions

Laminin interactions
626
set Laminin interactions
setSize 30
pANOVA 1.54e-06
s.dist 0.507
p.adjustANOVA 1.94e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
LAMA5 7035
NID1 6988
LAMA3 6917
COL18A1 6872
LAMB1 6787
ITGA3 6774
COL4A1 6492
HSPG2 6439
COL4A2 6432
ITGB4 6414
LAMA2 5859
ITGA1 4864
COL4A6 4606
ITGB1 4290
COL4A5 3912
ITGA6 3776
LAMA4 3639
LAMC1 3149
COL4A4 2640
ITGA7 2519

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LAMA5 7035
NID1 6988
LAMA3 6917
COL18A1 6872
LAMB1 6787
ITGA3 6774
COL4A1 6492
HSPG2 6439
COL4A2 6432
ITGB4 6414
LAMA2 5859
ITGA1 4864
COL4A6 4606
ITGB1 4290
COL4A5 3912
ITGA6 3776
LAMA4 3639
LAMC1 3149
COL4A4 2640
ITGA7 2519
NID2 2251
COL7A1 967
COL4A3 892
LAMC2 582
LAMB2 563
LAMA1 -56
ITGA2 -233
ITGAV -743
LAMC3 -5840
LAMB3 -9095



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               cachem_1.0.8            zlibbioc_1.48.0        
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] yaml_2.3.8              rstudioapi_0.15.0       abind_1.4-5            
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report