Mitch Report

date generated: 2024-03-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
5_8S_rRNA	4.1673803
7SK	0.1073247
A1BG	1.2922315
A1BG.AS1	0.8714241
A2M	-1.5583202
A2M.AS1	0.5646184

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	2612
num_genes_in_profile	16438
duplicated_genes_present	0
num_profile_genes_in_sets	8232
num_profile_genes_not_in_sets	8206

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2612
num_genesets_excluded	1150
num_genesets_included	1462

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pANOVA	s.dist	p.adjustANOVA
Folding of actin by CCT/TriC	10	2.12e-04	-0.676	1.49e-03
Establishment of Sister Chromatid Cohesion	11	2.02e-04	-0.647	1.43e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	4.41e-04	0.642	3.01e-03
Biotin transport and metabolism	11	1.05e-03	0.571	6.68e-03
Cohesin Loading onto Chromatin	10	1.92e-03	-0.567	1.10e-02
Gluconeogenesis	29	1.71e-07	0.561	1.84e-06
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	8.13e-04	-0.558	5.23e-03
Somitogenesis	50	1.14e-11	-0.555	4.26e-10
Regulation of ornithine decarboxylase (ODC)	48	2.96e-11	-0.555	9.40e-10
Glycogen breakdown (glycogenolysis)	14	3.85e-04	0.548	2.66e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	5.25e-11	-0.547	1.54e-09
Negative regulation of NOTCH4 signaling	54	8.43e-12	-0.537	3.52e-10
SLBP independent Processing of Histone Pre-mRNAs	10	3.65e-03	-0.531	1.88e-02
Autodegradation of the E3 ubiquitin ligase COP1	49	1.57e-10	-0.528	3.55e-09
Ubiquitin-dependent degradation of Cyclin D	50	1.11e-10	-0.527	2.88e-09
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	1.76e-10	-0.527	3.78e-09
p53-Independent DNA Damage Response	49	1.76e-10	-0.527	3.78e-09
p53-Independent G1/S DNA damage checkpoint	49	1.76e-10	-0.527	3.78e-09
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	5.15e-11	-0.526	1.54e-09
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.69e-03	-0.523	1.46e-02
Vpu mediated degradation of CD4	50	3.32e-10	-0.514	6.48e-09
Vif-mediated degradation of APOBEC3G	52	2.21e-10	-0.509	4.55e-09
SCF-beta-TrCP mediated degradation of Emi1	53	1.51e-10	-0.508	3.51e-09
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.89e-10	-0.506	4.00e-09
Leading Strand Synthesis	14	1.08e-03	-0.505	6.80e-03
Polymerase switching	14	1.08e-03	-0.505	6.80e-03
Hh mutants abrogate ligand secretion	55	1.24e-10	-0.501	3.07e-09
Mitotic Telophase/Cytokinesis	13	1.75e-03	-0.501	1.02e-02
Beta-oxidation of very long chain fatty acids	10	6.18e-03	0.500	2.80e-02
Regulation of Apoptosis	51	7.25e-10	-0.499	1.22e-08
Hh mutants are degraded by ERAD	53	4.44e-10	-0.495	8.22e-09
Cross-presentation of soluble exogenous antigens (endosomes)	46	7.18e-09	-0.493	9.13e-08
Degradation of GLI1 by the proteasome	57	1.41e-10	-0.491	3.37e-09
APC/C:Cdc20 mediated degradation of mitotic proteins	73	4.32e-13	-0.490	2.75e-11
Orc1 removal from chromatin	67	4.76e-12	-0.488	2.11e-10
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	71	1.28e-12	-0.487	7.18e-11
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.15e-09	-0.483	1.81e-08
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	74	8.12e-13	-0.481	4.75e-11
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	70	3.83e-12	-0.480	1.81e-10
Branched-chain amino acid catabolism	21	1.51e-04	0.478	1.11e-03
GLI3 is processed to GLI3R by the proteasome	57	5.02e-10	-0.476	8.95e-09
Regulation of pyruvate dehydrogenase (PDH) complex	15	1.43e-03	0.475	8.68e-03
Regulation of RAS by GAPs	65	3.59e-11	-0.475	1.12e-09
Regulation of RUNX3 expression and activity	55	1.24e-09	-0.473	1.90e-08
Downstream signaling events of B Cell Receptor (BCR)	78	5.29e-13	-0.473	3.22e-11
Striated Muscle Contraction	32	3.88e-06	0.472	3.48e-05
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	1.57e-03	-0.471	9.32e-03
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	1.57e-03	-0.471	9.32e-03
SCF(Skp2)-mediated degradation of p27/p21	59	3.91e-10	-0.471	7.53e-09
Degradation of GLI2 by the proteasome	57	7.77e-10	-0.471	1.29e-08

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
Folding of actin by CCT/TriC	10	2.12e-04	-0.676000	1.49e-03
Establishment of Sister Chromatid Cohesion	11	2.02e-04	-0.647000	1.43e-03
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	4.41e-04	0.642000	3.01e-03
Biotin transport and metabolism	11	1.05e-03	0.571000	6.68e-03
Cohesin Loading onto Chromatin	10	1.92e-03	-0.567000	1.10e-02
Gluconeogenesis	29	1.71e-07	0.561000	1.84e-06
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	8.13e-04	-0.558000	5.23e-03
Somitogenesis	50	1.14e-11	-0.555000	4.26e-10
Regulation of ornithine decarboxylase (ODC)	48	2.96e-11	-0.555000	9.40e-10
Glycogen breakdown (glycogenolysis)	14	3.85e-04	0.548000	2.66e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	5.25e-11	-0.547000	1.54e-09
Negative regulation of NOTCH4 signaling	54	8.43e-12	-0.537000	3.52e-10
SLBP independent Processing of Histone Pre-mRNAs	10	3.65e-03	-0.531000	1.88e-02
Autodegradation of the E3 ubiquitin ligase COP1	49	1.57e-10	-0.528000	3.55e-09
Ubiquitin-dependent degradation of Cyclin D	50	1.11e-10	-0.527000	2.88e-09
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	1.76e-10	-0.527000	3.78e-09
p53-Independent DNA Damage Response	49	1.76e-10	-0.527000	3.78e-09
p53-Independent G1/S DNA damage checkpoint	49	1.76e-10	-0.527000	3.78e-09
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	5.15e-11	-0.526000	1.54e-09
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	2.69e-03	-0.523000	1.46e-02
Vpu mediated degradation of CD4	50	3.32e-10	-0.514000	6.48e-09
Vif-mediated degradation of APOBEC3G	52	2.21e-10	-0.509000	4.55e-09
SCF-beta-TrCP mediated degradation of Emi1	53	1.51e-10	-0.508000	3.51e-09
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	1.89e-10	-0.506000	4.00e-09
Leading Strand Synthesis	14	1.08e-03	-0.505000	6.80e-03
Polymerase switching	14	1.08e-03	-0.505000	6.80e-03
Hh mutants abrogate ligand secretion	55	1.24e-10	-0.501000	3.07e-09
Mitotic Telophase/Cytokinesis	13	1.75e-03	-0.501000	1.02e-02
Beta-oxidation of very long chain fatty acids	10	6.18e-03	0.500000	2.80e-02
Regulation of Apoptosis	51	7.25e-10	-0.499000	1.22e-08
Hh mutants are degraded by ERAD	53	4.44e-10	-0.495000	8.22e-09
Cross-presentation of soluble exogenous antigens (endosomes)	46	7.18e-09	-0.493000	9.13e-08
Degradation of GLI1 by the proteasome	57	1.41e-10	-0.491000	3.37e-09
APC/C:Cdc20 mediated degradation of mitotic proteins	73	4.32e-13	-0.490000	2.75e-11
Orc1 removal from chromatin	67	4.76e-12	-0.488000	2.11e-10
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	71	1.28e-12	-0.487000	7.18e-11
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.15e-09	-0.483000	1.81e-08
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	74	8.12e-13	-0.481000	4.75e-11
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	70	3.83e-12	-0.480000	1.81e-10
Branched-chain amino acid catabolism	21	1.51e-04	0.478000	1.11e-03
GLI3 is processed to GLI3R by the proteasome	57	5.02e-10	-0.476000	8.95e-09
Regulation of pyruvate dehydrogenase (PDH) complex	15	1.43e-03	0.475000	8.68e-03
Regulation of RAS by GAPs	65	3.59e-11	-0.475000	1.12e-09
Regulation of RUNX3 expression and activity	55	1.24e-09	-0.473000	1.90e-08
Downstream signaling events of B Cell Receptor (BCR)	78	5.29e-13	-0.473000	3.22e-11
Striated Muscle Contraction	32	3.88e-06	0.472000	3.48e-05
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	1.57e-03	-0.471000	9.32e-03
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	1.57e-03	-0.471000	9.32e-03
SCF(Skp2)-mediated degradation of p27/p21	59	3.91e-10	-0.471000	7.53e-09
Degradation of GLI2 by the proteasome	57	7.77e-10	-0.471000	1.29e-08
Hedgehog ligand biogenesis	59	4.42e-10	-0.470000	8.22e-09
Stabilization of p53	54	2.43e-09	-0.469000	3.42e-08
The role of GTSE1 in G2/M progression after G2 checkpoint	69	1.60e-11	-0.469000	5.46e-10
Defective CFTR causes cystic fibrosis	57	1.06e-09	-0.467000	1.69e-08
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	10	1.12e-02	0.463000	4.44e-02
Diseases of hemostasis	10	1.12e-02	0.463000	4.44e-02
Activation of NF-kappaB in B cells	65	1.20e-10	-0.462000	3.04e-09
APC/C:Cdc20 mediated degradation of Securin	66	1.00e-10	-0.460000	2.71e-09
Autodegradation of Cdh1 by Cdh1:APC/C	64	2.06e-10	-0.459000	4.31e-09
NIK–>noncanonical NF-kB signaling	57	2.01e-09	-0.459000	2.89e-08
Deposition of new CENPA-containing nucleosomes at the centromere	30	1.37e-05	-0.459000	1.12e-04
Nucleosome assembly	30	1.37e-05	-0.459000	1.12e-04
Prefoldin mediated transfer of substrate to CCT/TriC	24	1.04e-04	-0.458000	7.75e-04
Telomere C-strand synthesis initiation	13	4.43e-03	-0.456000	2.16e-02
Metabolism of polyamines	56	5.17e-09	-0.451000	6.88e-08
CDK-mediated phosphorylation and removal of Cdc6	70	9.58e-11	-0.447000	2.64e-09
Formation of paraxial mesoderm	62	1.17e-09	-0.447000	1.82e-08
Signaling by NOTCH4	81	3.62e-12	-0.447000	1.76e-10
Degradation of AXIN	53	2.16e-08	-0.445000	2.58e-07
Regulation of APC/C activators between G1/S and early anaphase	78	1.27e-11	-0.444000	4.51e-10
Dectin-1 mediated noncanonical NF-kB signaling	58	5.45e-09	-0.443000	7.05e-08
Synthesis of PIPs at the late endosome membrane	11	1.10e-02	-0.443000	4.42e-02
Carnitine metabolism	14	4.18e-03	0.442000	2.06e-02
Formation of tubulin folding intermediates by CCT/TriC	20	6.48e-04	-0.441000	4.26e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	27	8.82e-05	-0.436000	6.64e-04
Degradation of DVL	55	2.31e-08	-0.436000	2.74e-07
Switching of origins to a post-replicative state	88	1.73e-12	-0.435000	9.27e-11
Unwinding of DNA	12	9.13e-03	-0.435000	3.88e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	69	4.40e-10	-0.434000	8.22e-09
Condensation of Prometaphase Chromosomes	11	1.34e-02	-0.430000	5.08e-02
G2/M Checkpoints	127	7.31e-17	-0.429000	1.19e-14
APC/C-mediated degradation of cell cycle proteins	85	1.11e-11	-0.426000	4.26e-10
Regulation of mitotic cell cycle	85	1.11e-11	-0.426000	4.26e-10
Telomere Extension By Telomerase	21	7.76e-04	-0.424000	5.04e-03
Synthesis of DNA	117	3.51e-15	-0.421000	3.42e-13
Signaling by Leptin	11	1.56e-02	0.421000	5.74e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	6.61e-09	-0.419000	8.47e-08
Assembly of the pre-replicative complex	88	1.22e-11	-0.418000	4.45e-10
Citric acid cycle (TCA cycle)	22	6.94e-04	0.418000	4.55e-03
Separation of Sister Chromatids	175	1.90e-21	-0.417000	3.97e-19
Polymerase switching on the C-strand of the telomere	26	2.41e-04	-0.416000	1.68e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.27e-09	-0.414000	1.91e-08
DNA Replication Pre-Initiation	104	3.76e-13	-0.412000	2.50e-11
G1/S DNA Damage Checkpoints	63	1.67e-08	-0.411000	2.03e-07
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	1.87e-02	-0.409000	6.61e-02
Polo-like kinase mediated events	14	8.07e-03	-0.409000	3.48e-02
Activation of the pre-replicative complex	31	8.28e-05	-0.408000	6.31e-04
DNA Replication	129	1.25e-15	-0.408000	1.30e-13
Crosslinking of collagen fibrils	16	4.83e-03	0.407000	2.28e-02
p53-Dependent G1 DNA Damage Response	62	3.02e-08	-0.407000	3.47e-07
p53-Dependent G1/S DNA damage checkpoint	62	3.02e-08	-0.407000	3.47e-07
Processing and activation of SUMO	10	2.63e-02	-0.406000	8.72e-02
DNA strand elongation	32	7.28e-05	-0.405000	5.57e-04
Pyruvate metabolism and Citric Acid (TCA) cycle	51	5.77e-07	0.405000	5.90e-06
Resolution of Sister Chromatid Cohesion	112	1.60e-13	-0.404000	1.17e-11
Translesion synthesis by POLK	17	4.07e-03	-0.402000	2.05e-02
CLEC7A (Dectin-1) induces NFAT activation	11	2.25e-02	-0.397000	7.65e-02
Regulation of RUNX2 expression and activity	70	1.01e-08	-0.396000	1.26e-07
SARS-CoV-1 modulates host translation machinery	36	3.95e-05	-0.396000	3.10e-04
Cyclin E associated events during G1/S transition	81	1.01e-09	-0.393000	1.62e-08
p130Cas linkage to MAPK signaling for integrins	11	2.43e-02	-0.392000	8.20e-02
SARS-CoV-2 modulates host translation machinery	49	2.69e-06	-0.388000	2.47e-05
G1/S Transition	127	4.72e-14	-0.387000	3.83e-12
Formation of the ternary complex, and subsequently, the 43S complex	51	1.71e-06	-0.387000	1.64e-05
Lagging Strand Synthesis	20	2.74e-03	-0.387000	1.47e-02
Mitotic Metaphase and Anaphase	219	1.30e-22	-0.384000	3.80e-20
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	88	5.01e-10	-0.384000	8.95e-09
Amplification of signal from the kinetochores	88	5.01e-10	-0.384000	8.95e-09
Mitotic Anaphase	218	2.07e-22	-0.383000	5.05e-20
Telomere C-strand (Lagging Strand) Synthesis	34	1.17e-04	-0.382000	8.65e-04
Cell Cycle Checkpoints	243	1.38e-24	-0.381000	6.71e-22
MAPK6/MAPK4 signaling	83	1.96e-09	-0.381000	2.84e-08
Association of TriC/CCT with target proteins during biosynthesis	35	9.75e-05	-0.381000	7.31e-04
Extension of Telomeres	49	4.13e-06	-0.380000	3.63e-05
Chromosome Maintenance	92	2.91e-10	-0.380000	5.84e-09
Killing mechanisms	10	3.74e-02	0.380000	1.15e-01
WNT5:FZD7-mediated leishmania damping	10	3.74e-02	0.380000	1.15e-01
S Phase	158	1.85e-16	-0.380000	2.46e-14
eNOS activation	11	3.07e-02	-0.376000	9.88e-02
Activation of ATR in response to replication stress	33	1.90e-04	-0.375000	1.36e-03
Translesion synthesis by REV1	16	9.51e-03	-0.374000	3.95e-02
ADP signalling through P2Y purinoceptor 12	15	1.20e-02	-0.374000	4.68e-02
Cyclin A:Cdk2-associated events at S phase entry	83	3.97e-09	-0.374000	5.38e-08
Viral mRNA Translation	88	1.47e-09	-0.373000	2.18e-08
Pyruvate metabolism	27	7.97e-04	0.373000	5.16e-03
MECP2 regulates neuronal receptors and channels	14	1.58e-02	-0.373000	5.80e-02
Formation of a pool of free 40S subunits	100	1.44e-10	-0.371000	3.40e-09
Glycogen metabolism	24	1.73e-03	0.369000	1.01e-02
Regulation of PTEN stability and activity	67	1.79e-07	-0.369000	1.91e-06
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.11e-02	-0.367000	4.42e-02
Regulation of expression of SLITs and ROBOs	162	9.90e-16	-0.366000	1.11e-13
E2F mediated regulation of DNA replication	21	3.76e-03	-0.365000	1.93e-02
Regulation of mRNA stability by proteins that bind AU-rich elements	87	4.11e-09	-0.365000	5.52e-08
Initial triggering of complement	15	1.45e-02	0.365000	5.42e-02
Asymmetric localization of PCP proteins	61	8.49e-07	-0.365000	8.44e-06
Signaling by the B Cell Receptor (BCR)	104	1.58e-10	-0.363000	3.55e-09
Peptide chain elongation	88	3.94e-09	-0.363000	5.38e-08
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	32	4.00e-04	-0.362000	2.75e-03
Hedgehog ‘on’ state	82	1.58e-08	-0.361000	1.94e-07
HDMs demethylate histones	21	4.28e-03	0.360000	2.10e-02
Synthesis of PIPs at the early endosome membrane	16	1.28e-02	-0.359000	4.91e-02
GTP hydrolysis and joining of the 60S ribosomal subunit	111	6.25e-11	-0.359000	1.79e-09
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	2.51e-02	-0.359000	8.42e-02
G1/S-Specific Transcription	26	1.55e-03	-0.359000	9.30e-03
FOXO-mediated transcription of cell death genes	15	1.63e-02	0.358000	5.95e-02
rRNA processing in the mitochondrion	10	4.99e-02	-0.358000	1.39e-01
EPHA-mediated growth cone collapse	24	2.51e-03	-0.356000	1.38e-02
Mitotic Spindle Checkpoint	105	2.99e-10	-0.356000	5.91e-09
Eukaryotic Translation Termination	92	3.93e-09	-0.355000	5.38e-08
Removal of the Flap Intermediate from the C-strand	17	1.13e-02	-0.355000	4.45e-02
SRP-dependent cotranslational protein targeting to membrane	111	1.09e-10	-0.355000	2.88e-09
L13a-mediated translational silencing of Ceruloplasmin expression	110	1.32e-10	-0.355000	3.21e-09
RHO GTPases activate CIT	19	7.47e-03	-0.355000	3.30e-02
rRNA modification in the nucleus and cytosol	59	2.65e-06	-0.354000	2.45e-05
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	3.43e-02	-0.353000	1.08e-01
Mitotic G1 phase and G1/S transition	145	3.03e-13	-0.351000	2.11e-11
Nuclear events mediated by NFE2L2	77	1.10e-07	-0.350000	1.20e-06
FRS-mediated FGFR3 signaling	14	2.36e-02	-0.349000	7.99e-02
Negative regulation of FLT3	13	2.99e-02	-0.348000	9.65e-02
Translesion synthesis by POLI	17	1.34e-02	-0.346000	5.08e-02
Downstream TCR signaling	80	8.97e-08	-0.346000	9.86e-07
MET activates RAP1 and RAC1	11	4.71e-02	-0.346000	1.36e-01
EML4 and NUDC in mitotic spindle formation	103	1.47e-09	-0.345000	2.18e-08
Mitochondrial Fatty Acid Beta-Oxidation	34	5.07e-04	0.345000	3.40e-03
Voltage gated Potassium channels	18	1.15e-02	0.344000	4.51e-02
Translation initiation complex formation	58	5.91e-06	-0.344000	5.11e-05
Degradation of beta-catenin by the destruction complex	83	6.26e-08	-0.344000	7.04e-07
Ribosomal scanning and start codon recognition	58	6.18e-06	-0.343000	5.31e-05
Processive synthesis on the C-strand of the telomere	19	1.00e-02	-0.341000	4.11e-02
rRNA processing	200	1.21e-16	-0.340000	1.77e-14
Eukaryotic Translation Elongation	93	1.68e-08	-0.339000	2.03e-07
rRNA processing in the nucleus and cytosol	190	8.87e-16	-0.338000	1.08e-13
UCH proteinases	85	6.96e-08	-0.338000	7.77e-07
Condensation of Prophase Chromosomes	19	1.11e-02	-0.337000	4.42e-02
Packaging Of Telomere Ends	12	4.35e-02	-0.337000	1.29e-01
Selenocysteine synthesis	92	2.71e-08	-0.335000	3.19e-07
ALK mutants bind TKIs	12	4.49e-02	-0.334000	1.32e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	8.17e-09	-0.334000	1.03e-07
ABC transporter disorders	68	1.97e-06	-0.334000	1.87e-05
Recognition of DNA damage by PCNA-containing replication complex	30	1.57e-03	-0.334000	9.32e-03
RHOBTB2 GTPase cycle	23	5.84e-03	-0.332000	2.67e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	5.68e-02	0.332000	1.53e-01
Major pathway of rRNA processing in the nucleolus and cytosol	180	1.80e-14	-0.331000	1.64e-12
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	25	4.14e-03	-0.331000	2.05e-02
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	25	4.14e-03	-0.331000	2.05e-02
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	25	4.14e-03	-0.331000	2.05e-02
Defective homologous recombination repair (HRR) due to PALB2 loss of function	25	4.14e-03	-0.331000	2.05e-02
APC-Cdc20 mediated degradation of Nek2A	26	3.46e-03	-0.331000	1.80e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	2.97e-08	-0.331000	3.47e-07
FCERI mediated NF-kB activation	78	4.49e-07	-0.331000	4.62e-06
Cap-dependent Translation Initiation	118	5.74e-10	-0.330000	9.99e-09
Eukaryotic Translation Initiation	118	5.74e-10	-0.330000	9.99e-09
RHO GTPases activate PKNs	37	5.22e-04	-0.330000	3.47e-03
DCC mediated attractive signaling	13	4.04e-02	-0.328000	1.22e-01
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	7.25e-02	0.328000	1.82e-01
TP53 Regulates Transcription of Death Receptors and Ligands	10	7.25e-02	-0.328000	1.82e-01
Telomere Maintenance	69	2.57e-06	-0.327000	2.41e-05
Metabolism of nitric oxide: NOS3 activation and regulation	15	2.85e-02	-0.327000	9.33e-02
Olfactory Signaling Pathway	26	4.10e-03	-0.325000	2.05e-02
Meiotic synapsis	31	1.79e-03	-0.324000	1.04e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	1.69e-05	-0.324000	1.37e-04
Interleukin-20 family signaling	14	3.62e-02	0.323000	1.13e-01
Cellular hexose transport	13	4.36e-02	0.323000	1.29e-01
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	12	5.28e-02	-0.323000	1.46e-01
RHO GTPases activate KTN1	10	7.72e-02	-0.323000	1.91e-01
Gastrulation	85	3.18e-07	-0.321000	3.32e-06
Removal of the Flap Intermediate	14	3.78e-02	-0.321000	1.16e-01
RHO GTPases Activate ROCKs	19	1.59e-02	-0.320000	5.82e-02
CLEC7A (Dectin-1) signaling	95	7.41e-08	-0.320000	8.20e-07
Incretin synthesis, secretion, and inactivation	13	4.68e-02	-0.319000	1.36e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	13	4.68e-02	-0.319000	1.36e-01
Chaperonin-mediated protein folding	76	1.77e-06	-0.317000	1.69e-05
Cellular response to hypoxia	72	3.37e-06	-0.317000	3.06e-05
APC/C:Cdc20 mediated degradation of Cyclin B	24	7.49e-03	-0.315000	3.30e-02
Protein folding	82	8.09e-07	-0.315000	8.10e-06
G2/M DNA damage checkpoint	58	3.32e-05	-0.315000	2.64e-04
Impaired BRCA2 binding to PALB2	24	8.04e-03	-0.313000	3.48e-02
Expression and translocation of olfactory receptors	22	1.15e-02	-0.311000	4.51e-02
PI-3K cascade:FGFR3	12	6.27e-02	-0.310000	1.65e-01
RHO GTPases Activate Formins	126	2.03e-09	-0.309000	2.89e-08
MASTL Facilitates Mitotic Progression	10	9.07e-02	-0.309000	2.15e-01
RHO GTPases activate IQGAPs	23	1.06e-02	-0.308000	4.30e-02
RIPK1-mediated regulated necrosis	30	3.85e-03	-0.305000	1.96e-02
Regulation of necroptotic cell death	30	3.85e-03	-0.305000	1.96e-02
G0 and Early G1	25	8.86e-03	-0.302000	3.78e-02
RHOB GTPase cycle	66	2.22e-05	-0.302000	1.78e-04
Cleavage of the damaged purine	15	4.31e-02	-0.302000	1.29e-01
Depurination	15	4.31e-02	-0.302000	1.29e-01
Recognition and association of DNA glycosylase with site containing an affected purine	15	4.31e-02	-0.302000	1.29e-01
Gap junction assembly	19	2.34e-02	-0.300000	7.94e-02
Influenza Viral RNA Transcription and Replication	135	1.80e-09	-0.300000	2.63e-08
ER-Phagosome pathway	79	4.44e-06	-0.299000	3.89e-05
Peroxisomal lipid metabolism	26	8.79e-03	0.297000	3.76e-02
RHO GTPases activate PAKs	21	1.88e-02	-0.296000	6.61e-02
Regulation of CDH11 gene transcription	10	1.07e-01	0.294000	2.40e-01
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	40	1.33e-03	-0.293000	8.19e-03
Diseases of DNA Double-Strand Break Repair	40	1.33e-03	-0.293000	8.19e-03
Impaired BRCA2 binding to RAD51	34	3.12e-03	-0.293000	1.65e-02
TNFR2 non-canonical NF-kB pathway	85	3.12e-06	-0.293000	2.85e-05
Degradation of cysteine and homocysteine	12	7.95e-02	0.292000	1.96e-01
Interleukin-15 signaling	13	6.81e-02	0.292000	1.75e-01
Regulation of BACH1 activity	11	9.39e-02	-0.292000	2.20e-01
Glycogen synthesis	13	6.91e-02	0.291000	1.77e-01
PECAM1 interactions	11	9.59e-02	-0.290000	2.24e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.15e-02	-0.290000	7.42e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.15e-02	-0.290000	7.42e-02
Rap1 signalling	13	7.04e-02	-0.290000	1.79e-01
Receptor-type tyrosine-protein phosphatases	12	8.39e-02	0.288000	2.03e-01
mRNA Splicing - Major Pathway	202	1.78e-12	-0.288000	9.27e-11
Synthesis of PA	31	5.53e-03	0.288000	2.57e-02
cGMP effects	14	6.21e-02	-0.288000	1.65e-01
Negative regulation of FGFR3 signaling	23	1.70e-02	-0.287000	6.11e-02
Processing of DNA double-strand break ends	61	1.09e-04	-0.287000	8.07e-04
RHOBTB GTPase Cycle	35	3.41e-03	-0.286000	1.78e-02
Presynaptic phase of homologous DNA pairing and strand exchange	39	2.01e-03	-0.286000	1.14e-02
Host Interactions of HIV factors	125	3.53e-08	-0.286000	4.02e-07
Interconversion of nucleotide di- and triphosphates	27	1.05e-02	-0.284000	4.28e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	33	4.95e-03	-0.283000	2.33e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.88e-07	-0.283000	1.97e-06
Nonsense-Mediated Decay (NMD)	114	1.88e-07	-0.283000	1.97e-06
Homologous DNA Pairing and Strand Exchange	42	1.54e-03	-0.283000	9.26e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	27	1.11e-02	-0.282000	4.43e-02
MyD88 deficiency (TLR2/4)	14	6.77e-02	0.282000	1.75e-01
Apoptosis	163	5.84e-10	-0.281000	1.00e-08
Programmed Cell Death	190	2.36e-11	-0.281000	7.84e-10
Signaling by FGFR3 in disease	16	5.15e-02	-0.281000	1.43e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	4.51e-02	-0.281000	1.32e-01
mRNA Splicing	210	2.92e-12	-0.280000	1.47e-10
Recycling pathway of L1	39	2.55e-03	-0.279000	1.39e-02
TCR signaling	99	1.60e-06	-0.279000	1.55e-05
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	15	6.19e-02	-0.278000	1.65e-01
Aggrephagy	33	5.72e-03	-0.278000	2.64e-02
PCP/CE pathway	87	7.52e-06	-0.278000	6.39e-05
Signaling by ROBO receptors	201	1.31e-11	-0.277000	4.55e-10
Inhibition of DNA recombination at telomere	26	1.46e-02	-0.277000	5.42e-02
Kinesins	47	1.07e-03	-0.276000	6.77e-03
Postmitotic nuclear pore complex (NPC) reformation	27	1.34e-02	-0.275000	5.08e-02
M Phase	345	3.12e-18	-0.273000	5.70e-16
Influenza Infection	154	5.33e-09	-0.273000	6.98e-08
NOTCH4 Intracellular Domain Regulates Transcription	19	3.96e-02	-0.273000	1.21e-01
Mitotic Prometaphase	189	1.12e-10	-0.272000	2.88e-09
IRAK4 deficiency (TLR2/4)	15	6.83e-02	0.272000	1.75e-01
Advanced glycosylation endproduct receptor signaling	11	1.19e-01	-0.271000	2.55e-01
Selenoamino acid metabolism	114	5.93e-07	-0.271000	5.98e-06
Cell Cycle	595	2.34e-29	-0.271000	1.71e-26
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	1.20e-01	0.271000	2.56e-01
PCNA-Dependent Long Patch Base Excision Repair	21	3.21e-02	-0.270000	1.02e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	1.21e-01	-0.270000	2.57e-01
Processive synthesis on the lagging strand	15	7.09e-02	-0.269000	1.79e-01
Nitric oxide stimulates guanylate cyclase	18	4.86e-02	-0.269000	1.38e-01
G beta:gamma signalling through PLC beta	15	7.18e-02	-0.268000	1.81e-01
Presynaptic function of Kainate receptors	15	7.18e-02	-0.268000	1.81e-01
NOTCH3 Intracellular Domain Regulates Transcription	22	2.93e-02	-0.268000	9.52e-02
SHC-mediated cascade:FGFR3	12	1.08e-01	-0.268000	2.41e-01
SARS-CoV-1-host interactions	94	7.14e-06	-0.268000	6.11e-05
Apoptotic execution phase	43	2.46e-03	-0.267000	1.35e-02
Cell Cycle, Mitotic	484	1.14e-23	-0.267000	4.18e-21
Platelet calcium homeostasis	21	3.50e-02	-0.266000	1.10e-01
Interleukin-1 signaling	107	2.07e-06	-0.266000	1.95e-05
EPHB-mediated forward signaling	39	4.09e-03	-0.266000	2.05e-02
Sphingolipid de novo biosynthesis	36	5.81e-03	-0.266000	2.67e-02
Acyl chain remodelling of PI	10	1.46e-01	0.266000	2.88e-01
mRNA decay by 3’ to 5’ exoribonuclease	13	9.94e-02	-0.264000	2.29e-01
RHOBTB1 GTPase cycle	23	2.92e-02	-0.263000	9.52e-02
Nephrin family interactions	19	4.79e-02	-0.262000	1.36e-01
Apoptotic cleavage of cellular proteins	35	7.33e-03	-0.262000	3.26e-02
Mitotic G2-G2/M phases	187	6.87e-10	-0.262000	1.17e-08
Termination of translesion DNA synthesis	31	1.19e-02	-0.261000	4.65e-02
Transcriptional regulation by RUNX3	95	1.11e-05	-0.261000	9.30e-05
Diseases of DNA repair	49	1.62e-03	-0.260000	9.51e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	2.45e-02	-0.260000	8.26e-02
Phosphorylation of the APC/C	20	4.43e-02	-0.260000	1.31e-01
G2/M Transition	185	1.25e-09	-0.259000	1.90e-08
RHOC GTPase cycle	70	1.87e-04	-0.258000	1.34e-03
Cytosolic iron-sulfur cluster assembly	13	1.07e-01	0.258000	2.40e-01
Prolonged ERK activation events	13	1.08e-01	-0.258000	2.41e-01
Activated NOTCH1 Transmits Signal to the Nucleus	28	1.83e-02	-0.258000	6.51e-02
VEGFR2 mediated cell proliferation	19	5.20e-02	-0.258000	1.44e-01
FRS-mediated FGFR4 signaling	14	9.62e-02	-0.257000	2.24e-01
Acetylcholine Neurotransmitter Release Cycle	10	1.61e-01	0.256000	3.11e-01
Beta-catenin independent WNT signaling	133	3.69e-07	-0.255000	3.83e-06
Signaling by NOTCH3	46	2.74e-03	-0.255000	1.47e-02
Regulation of IFNA/IFNB signaling	12	1.26e-01	0.255000	2.64e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	2.76e-02	-0.254000	9.08e-02
IRAK2 mediated activation of TAK1 complex	10	1.64e-01	-0.254000	3.15e-01
Metabolism of RNA	694	7.14e-30	-0.254000	1.04e-26
Sulfur amino acid metabolism	23	3.53e-02	0.254000	1.10e-01
SIRT1 negatively regulates rRNA expression	14	1.01e-01	-0.254000	2.31e-01
Gap junction trafficking and regulation	32	1.32e-02	-0.253000	5.04e-02
Glutathione synthesis and recycling	10	1.66e-01	0.253000	3.16e-01
RHO GTPase Effectors	246	1.00e-11	-0.252000	4.08e-10
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	48	2.55e-03	-0.252000	1.39e-02
Translesion Synthesis by POLH	18	6.50e-02	-0.251000	1.70e-01
Fc epsilon receptor (FCERI) signaling	126	1.21e-06	-0.251000	1.17e-05
Cytochrome c-mediated apoptotic response	13	1.18e-01	-0.250000	2.55e-01
Thrombin signalling through proteinase activated receptors (PARs)	24	3.40e-02	-0.250000	1.07e-01
Antigen processing-Cross presentation	92	3.51e-05	-0.250000	2.77e-04
Protein methylation	15	9.44e-02	-0.249000	2.21e-01
Post-chaperonin tubulin folding pathway	17	7.55e-02	-0.249000	1.88e-01
Negative epigenetic regulation of rRNA expression	55	1.41e-03	-0.249000	8.58e-03
Signaling by Hippo	20	5.40e-02	-0.249000	1.48e-01
Hedgehog ‘off’ state	104	1.26e-05	-0.248000	1.04e-04
Nuclear Envelope (NE) Reassembly	67	4.58e-04	-0.248000	3.10e-03
Processing of Capped Intronless Pre-mRNA	29	2.13e-02	-0.247000	7.39e-02
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	6.30e-02	-0.246000	1.66e-01
RHOV GTPase cycle	34	1.30e-02	-0.246000	4.98e-02
Transcriptional Regulation by E2F6	34	1.35e-02	-0.245000	5.08e-02
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	1.80e-01	-0.245000	3.33e-01
Early SARS-CoV-2 Infection Events	32	1.66e-02	-0.245000	5.99e-02
Glyoxylate metabolism and glycine degradation	22	4.72e-02	0.244000	1.36e-01
Transcriptional regulation by RUNX2	112	8.00e-06	-0.244000	6.76e-05
Regulated Necrosis	52	2.32e-03	-0.244000	1.28e-02
HIV Transcription Initiation	45	4.60e-03	-0.244000	2.19e-02
RNA Polymerase II HIV Promoter Escape	45	4.60e-03	-0.244000	2.19e-02
RNA Polymerase II Promoter Escape	45	4.60e-03	-0.244000	2.19e-02
RNA Polymerase II Transcription Initiation	45	4.60e-03	-0.244000	2.19e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	4.60e-03	-0.244000	2.19e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	4.60e-03	-0.244000	2.19e-02
Triglyceride metabolism	25	3.49e-02	0.244000	1.10e-01
Glycogen storage diseases	14	1.14e-01	0.244000	2.49e-01
Gap junction trafficking	30	2.13e-02	-0.243000	7.39e-02
C-type lectin receptors (CLRs)	121	4.01e-06	-0.243000	3.58e-05
Transcription of E2F targets under negative control by DREAM complex	18	7.51e-02	-0.242000	1.87e-01
Processing of Capped Intron-Containing Pre-mRNA	278	4.22e-12	-0.242000	1.93e-10
FRS-mediated FGFR1 signaling	15	1.06e-01	-0.241000	2.39e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	1.21e-01	-0.240000	2.56e-01
HIV Infection	221	9.34e-10	-0.239000	1.52e-08
Initiation of Nuclear Envelope (NE) Reformation	19	7.13e-02	-0.239000	1.80e-01
Activation of BAD and translocation to mitochondria	15	1.10e-01	-0.239000	2.43e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	4.76e-02	-0.239000	1.36e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	3.91e-02	-0.238000	1.20e-01
Collagen biosynthesis and modifying enzymes	55	2.23e-03	0.238000	1.26e-02
RND3 GTPase cycle	36	1.36e-02	-0.238000	5.13e-02
Formation of apoptosome	11	1.73e-01	-0.238000	3.25e-01
Regulation of the apoptosome activity	11	1.73e-01	-0.238000	3.25e-01
BBSome-mediated cargo-targeting to cilium	22	5.41e-02	-0.237000	1.48e-01
Activation of kainate receptors upon glutamate binding	22	5.47e-02	-0.237000	1.49e-01
Amino acid transport across the plasma membrane	22	5.53e-02	0.236000	1.50e-01
InlB-mediated entry of Listeria monocytogenes into host cell	13	1.41e-01	-0.236000	2.82e-01
RHO GTPases Activate WASPs and WAVEs	36	1.45e-02	-0.235000	5.42e-02
Metabolism of folate and pterines	17	9.34e-02	0.235000	2.19e-01
PKA activation in glucagon signalling	15	1.15e-01	0.235000	2.50e-01
G beta:gamma signalling through BTK	13	1.43e-01	-0.235000	2.85e-01
CD28 dependent PI3K/Akt signaling	20	6.93e-02	0.235000	1.77e-01
RAS processing	22	5.72e-02	-0.234000	1.53e-01
Signaling by FGFR3	33	2.02e-02	-0.234000	7.07e-02
Signaling by NOTCH	174	1.17e-07	-0.233000	1.26e-06
Aspirin ADME	15	1.19e-01	0.233000	2.55e-01
Oncogene Induced Senescence	33	2.09e-02	-0.232000	7.30e-02
Sema4D in semaphorin signaling	24	4.88e-02	-0.232000	1.38e-01
Assembly of the ORC complex at the origin of replication	14	1.32e-01	-0.232000	2.74e-01
Interleukin-12 family signaling	45	7.04e-03	-0.232000	3.14e-02
Metalloprotease DUBs	19	7.97e-02	-0.232000	1.96e-01
G-protein activation	18	8.96e-02	-0.231000	2.13e-01
Negative regulation of FGFR4 signaling	23	5.51e-02	-0.231000	1.49e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	7.41e-02	-0.231000	1.85e-01
Activation of BH3-only proteins	29	3.17e-02	-0.231000	1.01e-01
Meiosis	50	4.91e-03	-0.230000	2.32e-02
Signal amplification	26	4.29e-02	-0.229000	1.29e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	11	1.88e-01	-0.229000	3.42e-01
KEAP1-NFE2L2 pathway	102	6.58e-05	-0.229000	5.15e-04
Interleukin-1 family signaling	133	5.30e-06	-0.229000	4.61e-05
NRIF signals cell death from the nucleus	16	1.14e-01	-0.228000	2.49e-01
ABC-family proteins mediated transport	92	1.64e-04	-0.227000	1.18e-03
Downstream signaling of activated FGFR3	19	8.67e-02	-0.227000	2.08e-01
RAB geranylgeranylation	54	3.93e-03	-0.227000	1.99e-02
Hyaluronan uptake and degradation	11	1.93e-01	-0.227000	3.47e-01
Phase 2 - plateau phase	10	2.15e-01	0.226000	3.71e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	16	1.18e-01	-0.226000	2.55e-01
Regulation of CDH11 function	10	2.17e-01	0.226000	3.72e-01
IRAK1 recruits IKK complex	14	1.45e-01	-0.225000	2.88e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	1.45e-01	-0.225000	2.88e-01
NR1H2 and NR1H3-mediated signaling	39	1.51e-02	0.225000	5.57e-02
COPI-independent Golgi-to-ER retrograde traffic	44	9.90e-03	-0.225000	4.09e-02
TICAM1, RIP1-mediated IKK complex recruitment	19	9.01e-02	-0.225000	2.14e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.09e-01	-0.224000	2.43e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	1.09e-01	-0.224000	2.43e-01
FRS-mediated FGFR2 signaling	16	1.22e-01	-0.223000	2.58e-01
DNA Damage/Telomere Stress Induced Senescence	33	2.72e-02	-0.222000	8.96e-02
E3 ubiquitin ligases ubiquitinate target proteins	43	1.21e-02	-0.221000	4.68e-02
CTNNB1 S33 mutants aren’t phosphorylated	15	1.39e-01	-0.221000	2.82e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	1.39e-01	-0.221000	2.82e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	1.39e-01	-0.221000	2.82e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	1.39e-01	-0.221000	2.82e-01
Signaling by CTNNB1 phospho-site mutants	15	1.39e-01	-0.221000	2.82e-01
Signaling by GSK3beta mutants	15	1.39e-01	-0.221000	2.82e-01
Regulation of TLR by endogenous ligand	15	1.39e-01	0.220000	2.82e-01
Cellular response to starvation	149	3.61e-06	-0.220000	3.26e-05
Spry regulation of FGF signaling	16	1.28e-01	-0.220000	2.67e-01
NoRC negatively regulates rRNA expression	52	6.13e-03	-0.220000	2.79e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	1.41e-01	-0.220000	2.82e-01
Chaperone Mediated Autophagy	20	8.90e-02	-0.220000	2.12e-01
ERBB2 Regulates Cell Motility	11	2.08e-01	-0.219000	3.64e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	84	5.12e-04	0.219000	3.42e-03
Defective pyroptosis	19	9.79e-02	-0.219000	2.27e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	21	8.34e-02	-0.218000	2.03e-01
Nonhomologous End-Joining (NHEJ)	34	2.80e-02	-0.218000	9.17e-02
Tryptophan catabolism	10	2.34e-01	0.218000	3.91e-01
Intrinsic Pathway for Apoptosis	53	6.27e-03	-0.217000	2.84e-02
Golgi Cisternae Pericentriolar Stack Reorganization	14	1.60e-01	-0.217000	3.10e-01
Serotonin Neurotransmitter Release Cycle	12	1.93e-01	0.217000	3.47e-01
Signaling by NOTCH2	29	4.36e-02	-0.217000	1.29e-01
Thromboxane signalling through TP receptor	19	1.02e-01	-0.217000	2.33e-01
Downregulation of TGF-beta receptor signaling	26	5.66e-02	-0.216000	1.53e-01
Intraflagellar transport	48	9.66e-03	-0.216000	4.00e-02
IL-6-type cytokine receptor ligand interactions	14	1.62e-01	0.216000	3.13e-01
Assembly of active LPL and LIPC lipase complexes	12	1.96e-01	0.216000	3.51e-01
SARS-CoV-1 Infection	136	1.44e-05	-0.216000	1.17e-04
Beta-catenin phosphorylation cascade	17	1.25e-01	-0.215000	2.63e-01
Surfactant metabolism	19	1.05e-01	-0.215000	2.38e-01
Activation of the AP-1 family of transcription factors	10	2.40e-01	-0.214000	3.97e-01
Anchoring fibril formation	13	1.81e-01	0.214000	3.33e-01
p75NTR recruits signalling complexes	13	1.82e-01	-0.214000	3.33e-01
Interleukin-12 signaling	39	2.09e-02	-0.214000	7.31e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	30	4.32e-02	-0.213000	1.29e-01
Glucose metabolism	84	7.42e-04	0.213000	4.84e-03
Negative regulation of FGFR2 signaling	25	6.68e-02	-0.212000	1.73e-01
Glucagon-type ligand receptors	17	1.31e-01	-0.212000	2.72e-01
Dual incision in TC-NER	65	3.21e-03	-0.211000	1.69e-02
Signal regulatory protein family interactions	11	2.25e-01	-0.211000	3.82e-01
RNA Polymerase II Pre-transcription Events	77	1.38e-03	-0.211000	8.46e-03
Deadenylation-dependent mRNA decay	50	1.00e-02	-0.211000	4.11e-02
Metabolism of Angiotensinogen to Angiotensins	13	1.89e-01	-0.211000	3.42e-01
FGFR2 mutant receptor activation	24	7.44e-02	-0.210000	1.85e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	68	2.72e-03	0.210000	1.47e-02
DNA Damage Bypass	46	1.36e-02	-0.210000	5.13e-02
RUNX3 regulates NOTCH signaling	14	1.78e-01	-0.208000	3.30e-01
Extra-nuclear estrogen signaling	64	4.16e-03	-0.207000	2.05e-02
Base-Excision Repair, AP Site Formation	22	9.30e-02	-0.207000	2.19e-01
Signaling by Hedgehog	137	3.07e-05	-0.206000	2.46e-04
AKT phosphorylates targets in the cytosol	14	1.85e-01	0.205000	3.37e-01
Effects of PIP2 hydrolysis	23	8.97e-02	-0.204000	2.13e-01
TGF-beta receptor signaling activates SMADs	46	1.66e-02	-0.204000	5.98e-02
Dopamine Neurotransmitter Release Cycle	16	1.57e-01	0.204000	3.07e-01
RHOH GTPase cycle	31	4.93e-02	-0.204000	1.38e-01
Mitochondrial tRNA aminoacylation	21	1.06e-01	0.204000	2.38e-01
Laminin interactions	29	5.87e-02	-0.203000	1.57e-01
G beta:gamma signalling through CDC42	15	1.74e-01	-0.203000	3.26e-01
FCGR3A-mediated phagocytosis	58	7.64e-03	-0.203000	3.31e-02
Leishmania phagocytosis	58	7.64e-03	-0.203000	3.31e-02
Parasite infection	58	7.64e-03	-0.203000	3.31e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	2.06e-01	-0.202000	3.62e-01
PI-3K cascade:FGFR4	12	2.25e-01	-0.202000	3.82e-01
Regulation of NPAS4 gene expression	12	2.25e-01	-0.202000	3.82e-01
SUMOylation of DNA replication proteins	46	1.81e-02	-0.202000	6.43e-02
Translation	292	3.65e-09	-0.201000	5.08e-08
Cleavage of the damaged pyrimidine	20	1.20e-01	-0.201000	2.55e-01
Depyrimidination	20	1.20e-01	-0.201000	2.55e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	20	1.20e-01	-0.201000	2.55e-01
Protein ubiquitination	63	5.85e-03	-0.201000	2.67e-02
Golgi Associated Vesicle Biogenesis	53	1.16e-02	-0.201000	4.52e-02
Norepinephrine Neurotransmitter Release Cycle	12	2.30e-01	0.200000	3.87e-01
HDR through Homologous Recombination (HRR)	66	5.22e-03	-0.199000	2.44e-02
Early Phase of HIV Life Cycle	14	1.98e-01	-0.199000	3.52e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	9.46e-03	-0.199000	3.95e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	9.46e-03	-0.199000	3.95e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	9.46e-03	-0.199000	3.95e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	9.46e-03	-0.199000	3.95e-02
Signaling by NOTCH1 in Cancer	57	9.46e-03	-0.199000	3.95e-02
Pentose phosphate pathway	13	2.15e-01	-0.198000	3.71e-01
Listeria monocytogenes entry into host cells	17	1.57e-01	-0.198000	3.07e-01
FGFR2 ligand binding and activation	10	2.78e-01	-0.198000	4.38e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	1.85e-01	-0.198000	3.37e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	30	6.11e-02	-0.198000	1.63e-01
Adrenaline,noradrenaline inhibits insulin secretion	23	1.01e-01	-0.197000	2.32e-01
Frs2-mediated activation	11	2.58e-01	-0.197000	4.17e-01
Collagen formation	75	3.23e-03	0.197000	1.69e-02
PTEN Regulation	138	6.83e-05	-0.196000	5.31e-04
Platelet homeostasis	70	4.56e-03	-0.196000	2.19e-02
Acyl chain remodelling of PE	19	1.41e-01	0.195000	2.82e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	9.16e-02	0.195000	2.16e-01
Signaling by FGFR4	33	5.33e-02	-0.194000	1.47e-01
Base Excision Repair	50	1.75e-02	-0.194000	6.26e-02
Aflatoxin activation and detoxification	13	2.26e-01	0.194000	3.83e-01
MAP2K and MAPK activation	35	4.74e-02	-0.194000	1.36e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	64	7.58e-03	-0.193000	3.31e-02
Synthesis of very long-chain fatty acyl-CoAs	18	1.57e-01	-0.193000	3.07e-01
Regulation of TP53 Activity through Phosphorylation	88	1.98e-03	-0.191000	1.14e-02
Signaling by FGFR2 in disease	34	5.45e-02	-0.191000	1.49e-01
Nucleotide biosynthesis	12	2.54e-01	0.190000	4.14e-01
Mitochondrial calcium ion transport	21	1.31e-01	0.190000	2.73e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	95	1.37e-03	-0.190000	8.44e-03
Caspase-mediated cleavage of cytoskeletal proteins	12	2.55e-01	-0.190000	4.16e-01
Signaling by Retinoic Acid	36	4.91e-02	0.190000	1.38e-01
Negative regulation of FGFR1 signaling	25	1.02e-01	-0.189000	2.32e-01
p75NTR signals via NF-kB	16	1.91e-01	-0.189000	3.44e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	8.43e-02	-0.189000	2.04e-01
PI-3K cascade:FGFR1	13	2.40e-01	-0.188000	3.96e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	1.26e-01	-0.188000	2.64e-01
Sema4D induced cell migration and growth-cone collapse	20	1.45e-01	-0.188000	2.88e-01
Gastrin-CREB signalling pathway via PKC and MAPK	16	1.93e-01	-0.188000	3.47e-01
Elevation of cytosolic Ca2+ levels	12	2.60e-01	-0.188000	4.19e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	9.50e-03	-0.188000	3.95e-02
Peroxisomal protein import	57	1.45e-02	0.187000	5.42e-02
Deadenylation of mRNA	22	1.29e-01	-0.187000	2.69e-01
ABC transporters in lipid homeostasis	13	2.44e-01	0.187000	4.00e-01
p38MAPK events	13	2.46e-01	-0.186000	4.03e-01
EPH-Ephrin signaling	84	3.23e-03	-0.186000	1.69e-02
Apoptotic factor-mediated response	20	1.50e-01	-0.186000	2.96e-01
Regulation of PTEN mRNA translation	11	2.86e-01	-0.186000	4.44e-01
NF-kB is activated and signals survival	13	2.46e-01	-0.186000	4.03e-01
Late Phase of HIV Life Cycle	132	2.34e-04	-0.186000	1.64e-03
Diseases associated with N-glycosylation of proteins	20	1.51e-01	0.185000	2.97e-01
Formation of RNA Pol II elongation complex	56	1.65e-02	-0.185000	5.97e-02
RNA Polymerase II Transcription Elongation	56	1.65e-02	-0.185000	5.97e-02
HDR through Single Strand Annealing (SSA)	36	5.50e-02	-0.185000	1.49e-01
Constitutive Signaling by Overexpressed ERBB2	11	2.92e-01	-0.183000	4.49e-01
Cargo trafficking to the periciliary membrane	46	3.14e-02	-0.183000	1.01e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	2.36e-01	-0.183000	3.95e-01
Downregulation of ERBB2 signaling	25	1.14e-01	-0.183000	2.49e-01
Synthesis, secretion, and deacylation of Ghrelin	11	2.94e-01	-0.183000	4.51e-01
Budding and maturation of HIV virion	27	1.01e-01	-0.183000	2.31e-01
HIV Life Cycle	145	1.53e-04	-0.182000	1.12e-03
Transcriptional regulation by RUNX1	160	7.06e-05	-0.182000	5.44e-04
IRF3-mediated induction of type I IFN	12	2.75e-01	-0.182000	4.36e-01
Dual Incision in GG-NER	41	4.38e-02	-0.182000	1.29e-01
APC truncation mutants have impaired AXIN binding	14	2.39e-01	-0.182000	3.96e-01
AXIN missense mutants destabilize the destruction complex	14	2.39e-01	-0.182000	3.96e-01
Signaling by AMER1 mutants	14	2.39e-01	-0.182000	3.96e-01
Signaling by APC mutants	14	2.39e-01	-0.182000	3.96e-01
Signaling by AXIN mutants	14	2.39e-01	-0.182000	3.96e-01
Truncations of AMER1 destabilize the destruction complex	14	2.39e-01	-0.182000	3.96e-01
Regulation of gene expression by Hypoxia-inducible Factor	10	3.19e-01	0.182000	4.76e-01
Alpha-protein kinase 1 signaling pathway	11	2.97e-01	-0.182000	4.53e-01
Metabolism of non-coding RNA	53	2.23e-02	-0.182000	7.62e-02
snRNP Assembly	53	2.23e-02	-0.182000	7.62e-02
mRNA Splicing - Minor Pathway	50	2.65e-02	-0.181000	8.77e-02
VEGFA-VEGFR2 Pathway	95	2.29e-03	-0.181000	1.28e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	5.66e-02	-0.181000	1.53e-01
SUMOylation of SUMOylation proteins	35	6.43e-02	-0.181000	1.69e-01
RNA Polymerase III Transcription Termination	23	1.34e-01	-0.181000	2.76e-01
The citric acid (TCA) cycle and respiratory electron transport	160	8.44e-05	0.180000	6.39e-04
Mitochondrial translation initiation	88	3.52e-03	-0.180000	1.82e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	8.80e-02	-0.180000	2.11e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	31	8.33e-02	-0.180000	2.03e-01
Transcription of the HIV genome	67	1.10e-02	-0.180000	4.42e-02
WNT ligand biogenesis and trafficking	16	2.14e-01	-0.179000	3.71e-01
Homology Directed Repair	101	1.85e-03	-0.179000	1.07e-02
Synthesis of IP2, IP, and Ins in the cytosol	12	2.83e-01	-0.179000	4.43e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	1.66e-01	-0.179000	3.16e-01
Nicotinamide salvaging	16	2.15e-01	0.179000	3.71e-01
O-glycosylation of TSR domain-containing proteins	35	6.72e-02	0.179000	1.74e-01
MAPK1/MAPK3 signaling	234	2.65e-06	-0.178000	2.45e-05
Regulation of Expression and Function of Type II Classical Cadherins	28	1.03e-01	0.178000	2.33e-01
Regulation of Homotypic Cell-Cell Adhesion	28	1.03e-01	0.178000	2.33e-01
SUMOylation of DNA damage response and repair proteins	77	6.88e-03	-0.178000	3.09e-02
Signaling by FGFR1	40	5.12e-02	-0.178000	1.42e-01
DNA Double-Strand Break Repair	131	4.51e-04	-0.178000	3.06e-03
Plasma lipoprotein remodeling	19	1.81e-01	0.177000	3.33e-01
Carboxyterminal post-translational modifications of tubulin	29	9.89e-02	-0.177000	2.29e-01
RAF/MAP kinase cascade	229	4.13e-06	-0.177000	3.63e-05
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	12	2.90e-01	-0.176000	4.48e-01
Downregulation of ERBB2:ERBB3 signaling	12	2.90e-01	-0.176000	4.48e-01
Phase 0 - rapid depolarisation	24	1.36e-01	0.176000	2.78e-01
ESR-mediated signaling	151	1.97e-04	-0.176000	1.41e-03
Interactions of Rev with host cellular proteins	37	6.51e-02	-0.175000	1.70e-01
Viral Infection Pathways	652	3.14e-14	-0.175000	2.70e-12
ADP signalling through P2Y purinoceptor 1	20	1.77e-01	-0.175000	3.29e-01
RNA Polymerase I Transcription Termination	30	9.88e-02	-0.174000	2.29e-01
Suppression of phagosomal maturation	13	2.78e-01	-0.174000	4.38e-01
RAC2 GTPase cycle	85	5.60e-03	-0.174000	2.59e-02
MAPK family signaling cascades	269	9.75e-07	-0.174000	9.56e-06
Acyl chain remodelling of PC	19	1.94e-01	0.172000	3.47e-01
PI-3K cascade:FGFR2	14	2.65e-01	-0.172000	4.23e-01
Defects in vitamin and cofactor metabolism	20	1.84e-01	0.172000	3.36e-01
Regulation of FOXO transcriptional activity by acetylation	10	3.49e-01	0.171000	5.08e-01
HCMV Early Events	75	1.05e-02	-0.171000	4.26e-02
Formation of definitive endoderm	10	3.49e-01	-0.171000	5.08e-01
Insulin receptor recycling	25	1.41e-01	-0.170000	2.82e-01
Regulation of CDH11 Expression and Function	27	1.26e-01	0.170000	2.64e-01
Interleukin-10 signaling	31	1.02e-01	0.170000	2.32e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	23	1.59e-01	-0.170000	3.10e-01
Diseases of mitotic cell cycle	38	7.06e-02	-0.170000	1.79e-01
Synthesis of PIPs at the plasma membrane	49	4.01e-02	-0.170000	1.22e-01
Assembly of collagen fibrils and other multimeric structures	51	3.63e-02	0.169000	1.13e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	15	2.58e-01	-0.169000	4.17e-01
RNA Polymerase III Abortive And Retractive Initiation	41	6.24e-02	-0.168000	1.65e-01
RNA Polymerase III Transcription	41	6.24e-02	-0.168000	1.65e-01
Signal transduction by L1	20	1.93e-01	-0.168000	3.47e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	3.34e-01	-0.168000	4.91e-01
Cell-extracellular matrix interactions	18	2.17e-01	-0.168000	3.72e-01
RAC3 GTPase cycle	87	6.92e-03	-0.168000	3.09e-02
Signaling by WNT	238	8.89e-06	-0.167000	7.47e-05
RNA Polymerase II Transcription Termination	66	1.88e-02	-0.167000	6.61e-02
Neurexins and neuroligins	37	7.87e-02	0.167000	1.94e-01
RND1 GTPase cycle	36	8.36e-02	-0.167000	2.03e-01
Rev-mediated nuclear export of HIV RNA	35	8.84e-02	-0.166000	2.11e-01
Signaling by FGFR2 IIIa TM	19	2.09e-01	-0.166000	3.65e-01
Biosynthesis of specialized proresolving mediators (SPMs)	15	2.65e-01	0.166000	4.23e-01
Lysine catabolism	11	3.40e-01	0.166000	4.97e-01
Interleukin-6 family signaling	20	1.99e-01	0.166000	3.54e-01
Interleukin receptor SHC signaling	20	2.00e-01	0.165000	3.55e-01
Mitochondrial translation	94	5.60e-03	-0.165000	2.59e-02
Mitochondrial translation termination	88	7.42e-03	-0.165000	3.29e-02
Mitochondrial translation elongation	88	7.61e-03	-0.165000	3.31e-02
Inactivation, recovery and regulation of the phototransduction cascade	18	2.27e-01	-0.164000	3.84e-01
Factors involved in megakaryocyte development and platelet production	116	2.25e-03	-0.164000	1.26e-02
Signaling by Rho GTPases	599	7.70e-12	-0.164000	3.31e-10
Signaling by ERBB2	45	5.67e-02	-0.164000	1.53e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	1.41e-01	-0.164000	2.82e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	1.41e-01	-0.164000	2.82e-01
Diseases of signal transduction by growth factor receptors and second messengers	389	3.55e-08	-0.163000	4.02e-07
Defective B3GALTL causes PpS	34	9.98e-02	0.163000	2.29e-01
Platelet sensitization by LDL	17	2.45e-01	-0.163000	4.03e-01
Synthesis of PC	23	1.77e-01	0.163000	3.29e-01
ER Quality Control Compartment (ERQC)	21	1.97e-01	-0.162000	3.52e-01
RNA Polymerase I Promoter Escape	37	8.75e-02	-0.162000	2.10e-01
Regulation of PLK1 Activity at G2/M Transition	86	9.47e-03	-0.162000	3.95e-02
TCF dependent signaling in response to WNT	157	4.68e-04	-0.162000	3.15e-03
Heme biosynthesis	12	3.33e-01	0.161000	4.90e-01
HSF1-dependent transactivation	32	1.14e-01	0.161000	2.49e-01
Pyroptosis	22	1.92e-01	-0.161000	3.47e-01
Nervous system development	504	8.32e-10	-0.160000	1.37e-08
Ub-specific processing proteases	155	5.87e-04	-0.160000	3.88e-03
SHC-mediated cascade:FGFR4	12	3.37e-01	-0.160000	4.94e-01
Regulation of HSF1-mediated heat shock response	78	1.46e-02	-0.160000	5.42e-02
RHOA GTPase cycle	143	9.69e-04	-0.160000	6.21e-03
RAC1 GTPase cycle	174	2.77e-04	-0.160000	1.92e-03
Disorders of transmembrane transporters	137	1.24e-03	-0.160000	7.77e-03
Viral Messenger RNA Synthesis	44	6.72e-02	-0.160000	1.74e-01
Regulation of actin dynamics for phagocytic cup formation	60	3.32e-02	-0.159000	1.05e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	1.20e-01	0.159000	2.55e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	33	1.14e-01	-0.159000	2.49e-01
Downstream signaling of activated FGFR4	19	2.31e-01	-0.159000	3.88e-01
Collagen chain trimerization	33	1.15e-01	0.159000	2.50e-01
Pausing and recovery of Tat-mediated HIV elongation	30	1.33e-01	-0.159000	2.74e-01
Tat-mediated HIV elongation arrest and recovery	30	1.33e-01	-0.159000	2.74e-01
SARS-CoV-1 activates/modulates innate immune responses	39	8.70e-02	-0.158000	2.09e-01
Signaling by FGFR in disease	53	4.73e-02	-0.158000	1.36e-01
Free fatty acids regulate insulin secretion	10	3.90e-01	-0.157000	5.43e-01
Regulated proteolysis of p75NTR	11	3.68e-01	-0.157000	5.26e-01
Signaling by FGFR2	61	3.44e-02	-0.157000	1.08e-01
MET receptor recycling	10	3.93e-01	-0.156000	5.44e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	614	5.15e-11	-0.156000	1.54e-09
Ca2+ pathway	54	4.77e-02	-0.156000	1.36e-01
TRAF3-dependent IRF activation pathway	13	3.31e-01	0.156000	4.89e-01
Lysosome Vesicle Biogenesis	30	1.40e-01	-0.156000	2.82e-01
Infectious disease	819	5.61e-14	-0.155000	4.31e-12
Other interleukin signaling	19	2.41e-01	0.155000	3.98e-01
Axon guidance	484	5.35e-09	-0.155000	6.98e-08
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	8.16e-02	-0.155000	1.99e-01
HIV Transcription Elongation	42	8.16e-02	-0.155000	1.99e-01
Tat-mediated elongation of the HIV-1 transcript	42	8.16e-02	-0.155000	1.99e-01
Antiviral mechanism by IFN-stimulated genes	79	1.71e-02	-0.155000	6.13e-02
SARS-CoV-2 modulates autophagy	11	3.73e-01	0.155000	5.29e-01
RHOQ GTPase cycle	57	4.33e-02	-0.155000	1.29e-01
Smooth Muscle Contraction	35	1.13e-01	-0.155000	2.48e-01
Synthesis of PIPs at the Golgi membrane	15	3.00e-01	-0.155000	4.55e-01
DNA Double Strand Break Response	44	7.64e-02	-0.154000	1.89e-01
Class I peroxisomal membrane protein import	20	2.33e-01	-0.154000	3.90e-01
Signaling by NOTCH1	70	2.59e-02	-0.154000	8.64e-02
Collagen degradation	48	6.59e-02	0.153000	1.71e-01
PRC2 methylates histones and DNA	19	2.47e-01	-0.153000	4.05e-01
Signaling by ERBB4	49	6.35e-02	-0.153000	1.67e-01
Fatty acid metabolism	143	1.61e-03	0.153000	9.50e-03
Glycolysis	66	3.19e-02	0.153000	1.02e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	2.06e-01	-0.152000	3.62e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	2.92e-01	-0.152000	4.49e-01
SLC-mediated transmembrane transport	154	1.16e-03	0.152000	7.30e-03
TICAM1-dependent activation of IRF3/IRF7	12	3.63e-01	-0.152000	5.21e-01
Nuclear signaling by ERBB4	27	1.73e-01	-0.152000	3.25e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	3.63e-01	-0.152000	5.21e-01
Peptide hormone metabolism	54	5.43e-02	-0.151000	1.48e-01
Regulation of localization of FOXO transcription factors	12	3.64e-01	-0.151000	5.22e-01
Diseases associated with the TLR signaling cascade	27	1.75e-01	0.151000	3.26e-01
Diseases of Immune System	27	1.75e-01	0.151000	3.26e-01
Physiological factors	10	4.09e-01	0.151000	5.57e-01
mRNA Capping	29	1.60e-01	-0.151000	3.10e-01
Resolution of D-Loop Structures	34	1.28e-01	-0.151000	2.68e-01
Fcgamma receptor (FCGR) dependent phagocytosis	83	1.78e-02	-0.151000	6.36e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	2.03e-01	0.150000	3.59e-01
Disorders of Developmental Biology	11	3.89e-01	-0.150000	5.42e-01
Disorders of Nervous System Development	11	3.89e-01	-0.150000	5.42e-01
Loss of function of MECP2 in Rett syndrome	11	3.89e-01	-0.150000	5.42e-01
Pervasive developmental disorders	11	3.89e-01	-0.150000	5.42e-01
MHC class II antigen presentation	96	1.12e-02	-0.150000	4.44e-02
Golgi-to-ER retrograde transport	119	4.82e-03	-0.150000	2.28e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX)	12	3.70e-01	0.149000	5.26e-01
Plasma lipoprotein assembly	11	3.91e-01	0.149000	5.43e-01
SHC-mediated cascade:FGFR1	13	3.51e-01	-0.149000	5.10e-01
Formation of the cornified envelope	23	2.16e-01	-0.149000	3.71e-01
Keratinization	23	2.16e-01	-0.149000	3.71e-01
G alpha (z) signalling events	38	1.12e-01	-0.149000	2.47e-01
Resolution of Abasic Sites (AP sites)	38	1.12e-01	-0.149000	2.47e-01
Signaling by VEGF	104	8.81e-03	-0.149000	3.76e-02
Signaling by NTRK2 (TRKB)	22	2.27e-01	-0.149000	3.84e-01
Keratan sulfate biosynthesis	26	1.89e-01	-0.149000	3.43e-01
Signaling by EGFR in Cancer	21	2.39e-01	-0.149000	3.96e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	4.17e-01	0.148000	5.64e-01
Formation of the Early Elongation Complex	33	1.41e-01	-0.148000	2.82e-01
Formation of the HIV-1 Early Elongation Complex	33	1.41e-01	-0.148000	2.82e-01
RNA Polymerase III Transcription Initiation	36	1.25e-01	-0.148000	2.63e-01
Sensory processing of sound by inner hair cells of the cochlea	47	7.99e-02	-0.148000	1.96e-01
Trafficking and processing of endosomal TLR	12	3.76e-01	0.148000	5.32e-01
Assembly Of The HIV Virion	16	3.07e-01	-0.148000	4.62e-01
SUMOylation of DNA methylation proteins	16	3.07e-01	0.148000	4.62e-01
Phase 4 - resting membrane potential	10	4.19e-01	0.148000	5.67e-01
Blood group systems biosynthesis	13	3.57e-01	-0.147000	5.16e-01
PI Metabolism	77	2.56e-02	-0.147000	8.55e-02
AURKA Activation by TPX2	71	3.21e-02	-0.147000	1.02e-01
Activation of gene expression by SREBF (SREBP)	42	9.90e-02	0.147000	2.29e-01
HCMV Infection	98	1.21e-02	-0.147000	4.70e-02
Synthesis of PE	12	3.81e-01	0.146000	5.36e-01
Sensory processing of sound by outer hair cells of the cochlea	37	1.26e-01	-0.145000	2.64e-01
DARPP-32 events	23	2.28e-01	0.145000	3.86e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	4.05e-01	0.145000	5.55e-01
Insulin processing	20	2.63e-01	-0.145000	4.22e-01
G alpha (q) signalling events	126	5.25e-03	-0.144000	2.45e-02
Signaling by high-kinase activity BRAF mutants	31	1.65e-01	-0.144000	3.16e-01
Transport of the SLBP Dependant Mature mRNA	36	1.36e-01	-0.144000	2.78e-01
B-WICH complex positively regulates rRNA expression	37	1.30e-01	-0.144000	2.71e-01
Biosynthesis of DHA-derived SPMs	13	3.70e-01	0.144000	5.26e-01
Other semaphorin interactions	19	2.80e-01	0.143000	4.40e-01
RNA Polymerase III Chain Elongation	18	2.93e-01	-0.143000	4.50e-01
LDL clearance	17	3.08e-01	-0.143000	4.62e-01
TNFs bind their physiological receptors	18	2.94e-01	0.143000	4.51e-01
Downstream signaling of activated FGFR2	21	2.58e-01	-0.143000	4.17e-01
PIWI-interacting RNA (piRNA) biogenesis	21	2.58e-01	-0.143000	4.17e-01
Regulation of innate immune responses to cytosolic DNA	13	3.73e-01	-0.143000	5.29e-01
trans-Golgi Network Vesicle Budding	67	4.38e-02	-0.143000	1.29e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	2.09e-01	0.142000	3.65e-01
Signaling by FGFR4 in disease	10	4.36e-01	-0.142000	5.84e-01
RHOG GTPase cycle	71	3.85e-02	-0.142000	1.18e-01
Diseases associated with glycosylation precursor biosynthesis	15	3.41e-01	0.142000	4.98e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	1.41e-01	-0.142000	2.82e-01
Formation of Incision Complex in GG-NER	43	1.08e-01	-0.142000	2.41e-01
Anti-inflammatory response favouring Leishmania parasite infection	65	4.86e-02	-0.142000	1.38e-01
Leishmania parasite growth and survival	65	4.86e-02	-0.142000	1.38e-01
RHO GTPases Activate NADPH Oxidases	21	2.62e-01	-0.141000	4.21e-01
Transport of connexons to the plasma membrane	13	3.79e-01	-0.141000	5.35e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	2.58e-02	-0.141000	8.63e-02
Tie2 Signaling	15	3.47e-01	-0.140000	5.06e-01
Metabolism of water-soluble vitamins and cofactors	110	1.11e-02	0.140000	4.42e-02
Formation of HIV elongation complex in the absence of HIV Tat	44	1.08e-01	-0.140000	2.41e-01
Protein-protein interactions at synapses	58	6.53e-02	0.140000	1.70e-01
NPAS4 regulates expression of target genes	17	3.18e-01	0.140000	4.75e-01
Estrogen-dependent gene expression	90	2.21e-02	-0.140000	7.60e-02
ROS and RNS production in phagocytes	30	1.86e-01	-0.139000	3.38e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	1.72e-01	-0.139000	3.25e-01
Nuclear import of Rev protein	34	1.60e-01	-0.139000	3.10e-01
Loss of Nlp from mitotic centrosomes	68	4.72e-02	-0.139000	1.36e-01
Loss of proteins required for interphase microtubule organization from the centrosome	68	4.72e-02	-0.139000	1.36e-01
PINK1-PRKN Mediated Mitophagy	21	2.70e-01	-0.139000	4.30e-01
Transcriptional regulation of pluripotent stem cells	17	3.21e-01	-0.139000	4.78e-01
Sensory processing of sound	51	8.62e-02	-0.139000	2.08e-01
Nicotinate metabolism	28	2.04e-01	0.139000	3.59e-01
Interleukin-4 and Interleukin-13 signaling	86	2.64e-02	0.139000	8.74e-02
Mitotic Prophase	88	2.48e-02	-0.138000	8.35e-02
GABA receptor activation	38	1.40e-01	-0.138000	2.82e-01
Signaling by FGFR1 in disease	32	1.76e-01	-0.138000	3.28e-01
Transcriptional activation of mitochondrial biogenesis	50	9.10e-02	0.138000	2.15e-01
Signaling by KIT in disease	19	2.97e-01	-0.138000	4.53e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	2.97e-01	-0.138000	4.53e-01
AKT phosphorylates targets in the nucleus	10	4.51e-01	0.138000	5.98e-01
HIV elongation arrest and recovery	32	1.78e-01	-0.138000	3.30e-01
Pausing and recovery of HIV elongation	32	1.78e-01	-0.138000	3.30e-01
tRNA processing in the nucleus	59	6.94e-02	-0.137000	1.77e-01
Nuclear Pore Complex (NPC) Disassembly	36	1.57e-01	-0.136000	3.07e-01
Signaling by WNT in cancer	28	2.12e-01	-0.136000	3.70e-01
Growth hormone receptor signaling	19	3.05e-01	0.136000	4.60e-01
RNA polymerase II transcribes snRNA genes	71	4.78e-02	-0.136000	1.36e-01
Diseases of programmed cell death	47	1.07e-01	-0.136000	2.40e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	43	1.24e-01	-0.136000	2.61e-01
SHC-mediated cascade:FGFR2	14	3.79e-01	-0.136000	5.35e-01
Prostacyclin signalling through prostacyclin receptor	14	3.80e-01	-0.136000	5.35e-01
Diseases of carbohydrate metabolism	29	2.07e-01	0.135000	3.62e-01
Transport of the SLBP independent Mature mRNA	35	1.66e-01	-0.135000	3.16e-01
Oncogenic MAPK signaling	74	4.45e-02	-0.135000	1.31e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	3.81e-01	-0.135000	5.36e-01
Amine ligand-binding receptors	11	4.38e-01	-0.135000	5.87e-01
Signaling by FGFR	70	5.09e-02	-0.135000	1.42e-01
FLT3 Signaling	34	1.74e-01	-0.135000	3.26e-01
Maturation of nucleoprotein 9694631	15	3.67e-01	-0.135000	5.25e-01
Signaling by ERBB2 in Cancer	22	2.75e-01	-0.134000	4.36e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.68e-01	-0.134000	4.26e-01
Complement cascade	33	1.85e-01	0.133000	3.37e-01
Positive epigenetic regulation of rRNA expression	52	9.69e-02	-0.133000	2.25e-01
MAPK targets/ Nuclear events mediated by MAP kinases	31	2.00e-01	-0.133000	3.55e-01
Nucleotide Excision Repair	110	1.66e-02	-0.132000	5.98e-02
Acyl chain remodelling of PS	14	3.93e-01	0.132000	5.44e-01
Metabolism of cofactors	18	3.35e-01	-0.131000	4.91e-01
DNA Repair	282	1.58e-04	-0.131000	1.15e-03
Integrin signaling	22	2.89e-01	-0.131000	4.47e-01
Glycerophospholipid biosynthesis	101	2.34e-02	0.131000	7.94e-02
SARS-CoV-2-host interactions	176	2.84e-03	-0.131000	1.52e-02
Negative regulation of MET activity	19	3.25e-01	-0.130000	4.82e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	4.69e-02	-0.130000	1.36e-01
Cilium Assembly	187	2.31e-03	-0.129000	1.28e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	2.36e-01	-0.129000	3.95e-01
PERK regulates gene expression	32	2.06e-01	-0.129000	3.62e-01
Gene Silencing by RNA	78	4.92e-02	-0.129000	1.38e-01
Downstream signaling of activated FGFR1	21	3.07e-01	-0.129000	4.62e-01
FOXO-mediated transcription of cell cycle genes	15	3.88e-01	0.129000	5.42e-01
Regulation of beta-cell development	19	3.32e-01	-0.129000	4.89e-01
IKK complex recruitment mediated by RIP1	23	2.86e-01	-0.129000	4.44e-01
SHC1 events in ERBB4 signaling	10	4.82e-01	-0.128000	6.25e-01
Mitochondrial biogenesis	87	3.95e-02	0.128000	1.20e-01
RNA Polymerase I Promoter Clearance	56	9.96e-02	-0.127000	2.29e-01
RNA Polymerase I Transcription	56	9.96e-02	-0.127000	2.29e-01
ERK/MAPK targets	22	3.03e-01	-0.127000	4.58e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	4.88e-01	-0.127000	6.30e-01
Late endosomal microautophagy	31	2.23e-01	-0.127000	3.80e-01
Transcriptional regulation by small RNAs	53	1.12e-01	-0.126000	2.47e-01
NOTCH1 Intracellular Domain Regulates Transcription	47	1.35e-01	-0.126000	2.77e-01
Formation of TC-NER Pre-Incision Complex	53	1.12e-01	-0.126000	2.47e-01
HuR (ELAVL1) binds and stabilizes mRNA	10	4.91e-01	-0.126000	6.33e-01
Interleukin-7 signaling	18	3.56e-01	0.126000	5.15e-01
Activation of RAC1	11	4.72e-01	-0.125000	6.18e-01
RHO GTPase cycle	418	1.18e-05	-0.125000	9.83e-05
Caspase activation via Death Receptors in the presence of ligand	15	4.02e-01	-0.125000	5.52e-01
ISG15 antiviral mechanism	71	6.97e-02	-0.125000	1.77e-01
PPARA activates gene expression	104	2.86e-02	0.124000	9.34e-02
RHOU GTPase cycle	39	1.80e-01	-0.124000	3.33e-01
Metal ion SLC transporters	18	3.62e-01	0.124000	5.21e-01
Depolymerization of the Nuclear Lamina	15	4.07e-01	-0.124000	5.56e-01
Regulation of signaling by CBL	22	3.16e-01	-0.124000	4.72e-01
Export of Viral Ribonucleoproteins from Nucleus	33	2.22e-01	-0.123000	3.79e-01
XBP1(S) activates chaperone genes	47	1.46e-01	0.123000	2.88e-01
EGFR downregulation	25	2.88e-01	-0.123000	4.47e-01
Interleukin-2 family signaling	33	2.24e-01	0.122000	3.82e-01
Response of EIF2AK1 (HRI) to heme deficiency	15	4.13e-01	0.122000	5.61e-01
Regulation of lipid metabolism by PPARalpha	106	2.99e-02	0.122000	9.65e-02
IRE1alpha activates chaperones	49	1.41e-01	0.122000	2.82e-01
FGFR2 alternative splicing	24	3.03e-01	-0.122000	4.58e-01
Epigenetic regulation of gene expression	133	1.60e-02	-0.121000	5.87e-02
TP53 Regulates Transcription of DNA Repair Genes	61	1.03e-01	-0.121000	2.33e-01
COPI-dependent Golgi-to-ER retrograde traffic	86	5.33e-02	-0.121000	1.47e-01
Unblocking of NMDA receptors, glutamate binding and activation	16	4.04e-01	0.121000	5.54e-01
Mitochondrial iron-sulfur cluster biogenesis	13	4.52e-01	0.121000	5.98e-01
tRNA processing	109	2.99e-02	-0.121000	9.65e-02
Purine catabolism	13	4.52e-01	-0.120000	5.98e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	25	2.98e-01	0.120000	4.53e-01
Trafficking of AMPA receptors	25	2.98e-01	0.120000	4.53e-01
Developmental Biology	784	1.24e-08	-0.120000	1.54e-07
Signalling to ERKs	32	2.41e-01	-0.120000	3.98e-01
Processing of SMDT1	15	4.22e-01	0.120000	5.71e-01
O-linked glycosylation of mucins	39	1.96e-01	-0.120000	3.51e-01
RHOF GTPase cycle	39	1.98e-01	-0.119000	3.52e-01
FGFR1 mutant receptor activation	25	3.03e-01	-0.119000	4.58e-01
Role of LAT2/NTAL/LAB on calcium mobilization	16	4.10e-01	0.119000	5.59e-01
TP53 Regulates Transcription of Cell Cycle Genes	44	1.73e-01	-0.119000	3.25e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	11	4.97e-01	-0.118000	6.38e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	3.99e-01	-0.118000	5.49e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	3.99e-01	-0.118000	5.49e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	4.79e-01	-0.118000	6.23e-01
ERKs are inactivated	13	4.62e-01	-0.118000	6.09e-01
activated TAK1 mediates p38 MAPK activation	23	3.29e-01	-0.117000	4.87e-01
Deubiquitination	226	2.43e-03	-0.117000	1.34e-02
The phototransduction cascade	19	3.77e-01	-0.117000	5.33e-01
Bacterial Infection Pathways	62	1.12e-01	-0.117000	2.47e-01
Mismatch Repair	15	4.36e-01	-0.116000	5.84e-01
PIP3 activates AKT signaling	240	2.01e-03	-0.116000	1.14e-02
Centrosome maturation	80	7.44e-02	-0.115000	1.85e-01
Recruitment of mitotic centrosome proteins and complexes	80	7.44e-02	-0.115000	1.85e-01
Sphingolipid metabolism	72	9.12e-02	-0.115000	2.15e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	4.26e-01	-0.115000	5.73e-01
Class B/2 (Secretin family receptors)	51	1.56e-01	-0.115000	3.07e-01
RHOJ GTPase cycle	53	1.49e-01	-0.115000	2.94e-01
Detoxification of Reactive Oxygen Species	33	2.56e-01	0.114000	4.16e-01
Signaling by TGF-beta Receptor Complex	92	5.85e-02	-0.114000	1.57e-01
Transport of bile salts and organic acids, metal ions and amine compounds	46	1.81e-01	0.114000	3.33e-01
Recruitment of NuMA to mitotic centrosomes	87	6.62e-02	-0.114000	1.72e-01
SARS-CoV-2 Infection	264	1.46e-03	-0.114000	8.83e-03
L1CAM interactions	98	5.20e-02	-0.114000	1.44e-01
FOXO-mediated transcription	57	1.40e-01	0.113000	2.82e-01
Signaling by Non-Receptor Tyrosine Kinases	49	1.72e-01	-0.113000	3.25e-01
Signaling by PTK6	49	1.72e-01	-0.113000	3.25e-01
STING mediated induction of host immune responses	15	4.50e-01	-0.113000	5.98e-01
Iron uptake and transport	53	1.57e-01	-0.113000	3.07e-01
CASP8 activity is inhibited	10	5.39e-01	-0.112000	6.76e-01
Dimerization of procaspase-8	10	5.39e-01	-0.112000	6.76e-01
Regulation by c-FLIP	10	5.39e-01	-0.112000	6.76e-01
SARS-CoV Infections	371	2.11e-04	-0.112000	1.49e-03
RHOD GTPase cycle	50	1.71e-01	-0.112000	3.24e-01
Cellular responses to stress	692	5.92e-07	-0.112000	5.98e-06
Intra-Golgi traffic	41	2.15e-01	0.112000	3.71e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.40e-01	-0.111000	5.88e-01
Signaling by SCF-KIT	39	2.29e-01	-0.111000	3.87e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	2.76e-01	-0.111000	4.37e-01
Reproduction	67	1.17e-01	-0.111000	2.54e-01
VEGFR2 mediated vascular permeability	27	3.20e-01	-0.110000	4.77e-01
Vpr-mediated nuclear import of PICs	34	2.65e-01	-0.110000	4.23e-01
Meiotic recombination	26	3.33e-01	-0.110000	4.90e-01
Cellular responses to stimuli	700	9.09e-07	-0.109000	8.98e-06
Ephrin signaling	18	4.24e-01	-0.109000	5.72e-01
Nuclear Envelope Breakdown	53	1.71e-01	-0.109000	3.24e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	3.28e-01	-0.109000	4.85e-01
Clathrin-mediated endocytosis	127	3.51e-02	-0.108000	1.10e-01
SUMOylation	168	1.56e-02	-0.108000	5.75e-02
RND2 GTPase cycle	36	2.62e-01	-0.108000	4.22e-01
tRNA modification in the nucleus and cytosol	43	2.21e-01	-0.108000	3.77e-01
HSF1 activation	25	3.54e-01	-0.107000	5.13e-01
Hemostasis	473	6.98e-05	-0.107000	5.40e-04
Muscle contraction	155	2.17e-02	0.107000	7.47e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	4.89e-01	-0.107000	6.31e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	5.06e-01	0.106000	6.46e-01
Sensory Perception	145	2.71e-02	-0.106000	8.94e-02
G beta:gamma signalling through PI3Kgamma	20	4.12e-01	-0.106000	5.60e-01
Glutamate Neurotransmitter Release Cycle	19	4.24e-01	0.106000	5.72e-01
Inflammasomes	21	4.01e-01	0.106000	5.51e-01
Regulation of insulin secretion	59	1.61e-01	-0.106000	3.12e-01
STAT3 nuclear events downstream of ALK signaling	10	5.64e-01	-0.105000	6.95e-01
Acyl chain remodelling of PG	11	5.46e-01	0.105000	6.81e-01
Pregnenolone biosynthesis	10	5.65e-01	0.105000	6.95e-01
SUMOylation of ubiquitinylation proteins	39	2.58e-01	-0.105000	4.17e-01
ZBP1(DAI) mediated induction of type I IFNs	19	4.30e-01	-0.105000	5.78e-01
Cyclin D associated events in G1	47	2.15e-01	-0.105000	3.71e-01
G1 Phase	47	2.15e-01	-0.105000	3.71e-01
SUMOylation of RNA binding proteins	47	2.17e-01	-0.104000	3.72e-01
Anchoring of the basal body to the plasma membrane	96	7.98e-02	-0.104000	1.96e-01
Stimuli-sensing channels	74	1.25e-01	0.103000	2.63e-01
Calnexin/calreticulin cycle	26	3.63e-01	-0.103000	5.21e-01
HDACs deacetylate histones	36	2.85e-01	-0.103000	4.44e-01
CRMPs in Sema3A signaling	15	4.93e-01	0.102000	6.34e-01
The activation of arylsulfatases	10	5.76e-01	-0.102000	7.02e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	4.80e-01	-0.102000	6.23e-01
Nuclear Receptor transcription pathway	41	2.59e-01	0.102000	4.17e-01
Azathioprine ADME	18	4.55e-01	-0.102000	6.00e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	3.61e-01	-0.102000	5.20e-01
CS/DS degradation	11	5.61e-01	-0.101000	6.92e-01
Netrin-1 signaling	42	2.56e-01	-0.101000	4.16e-01
Platelet activation, signaling and aggregation	217	1.03e-02	-0.101000	4.23e-02
EPH-ephrin mediated repulsion of cells	45	2.46e-01	-0.100000	4.03e-01
Metabolism of carbohydrates	253	6.31e-03	0.099900	2.85e-02
Disease	1456	2.90e-10	-0.099900	5.84e-09
Potassium Channels	52	2.13e-01	0.099800	3.71e-01
Nuclear events stimulated by ALK signaling in cancer	19	4.52e-01	-0.099700	5.98e-01
Gap junction degradation	12	5.51e-01	-0.099400	6.84e-01
RORA activates gene expression	18	4.66e-01	0.099300	6.12e-01
TRAF6 mediated IRF7 activation	15	5.06e-01	0.099300	6.46e-01
SUMOylation of transcription factors	17	4.79e-01	-0.099200	6.23e-01
Glutathione conjugation	29	3.56e-01	0.099100	5.15e-01
Neurotransmitter release cycle	33	3.25e-01	0.099000	4.82e-01
Response of Mtb to phagocytosis	23	4.12e-01	-0.098700	5.61e-01
Metabolism of proteins	1622	7.88e-11	-0.098100	2.22e-09
Cytosolic sensors of pathogen-associated DNA	62	1.82e-01	-0.098100	3.33e-01
Common Pathway of Fibrin Clot Formation	11	5.74e-01	0.098000	7.01e-01
Diseases associated with O-glycosylation of proteins	53	2.18e-01	0.098000	3.72e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	40	2.84e-01	-0.097800	4.44e-01
Signaling by RAS mutants	40	2.84e-01	-0.097800	4.44e-01
Signaling by moderate kinase activity BRAF mutants	40	2.84e-01	-0.097800	4.44e-01
Signaling downstream of RAS mutants	40	2.84e-01	-0.097800	4.44e-01
RAB GEFs exchange GTP for GDP on RABs	85	1.20e-01	-0.097700	2.55e-01
NS1 Mediated Effects on Host Pathways	40	2.86e-01	-0.097600	4.44e-01
SUMO E3 ligases SUMOylate target proteins	162	3.25e-02	-0.097500	1.03e-01
Signaling by EGFR	44	2.64e-01	-0.097300	4.23e-01
Regulation of TP53 Activity	152	3.93e-02	-0.097000	1.20e-01
Signaling by BRAF and RAF1 fusions	58	2.04e-01	-0.096500	3.59e-01
Antimicrobial peptides	18	4.79e-01	0.096400	6.23e-01
Signaling by ERBB2 KD Mutants	21	4.46e-01	-0.096100	5.94e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	2.78e-01	-0.095700	4.38e-01
Intracellular signaling by second messengers	276	6.66e-03	-0.095100	3.00e-02
Post NMDA receptor activation events	64	1.90e-01	-0.094900	3.43e-01
Amyloid fiber formation	40	3.00e-01	-0.094800	4.55e-01
Regulation of NF-kappa B signaling	18	4.87e-01	-0.094700	6.29e-01
Signaling by FLT3 fusion proteins	19	4.76e-01	0.094600	6.21e-01
Leishmania infection	146	4.89e-02	-0.094500	1.38e-01
Parasitic Infection Pathways	146	4.89e-02	-0.094500	1.38e-01
Endogenous sterols	19	4.76e-01	-0.094400	6.21e-01
Regulation of Complement cascade	29	3.80e-01	0.094300	5.35e-01
Infection with Mycobacterium tuberculosis	26	4.09e-01	-0.093600	5.57e-01
Cellular Senescence	131	6.47e-02	-0.093600	1.69e-01
Inositol phosphate metabolism	42	2.96e-01	-0.093300	4.53e-01
Pre-NOTCH Transcription and Translation	39	3.14e-01	-0.093200	4.70e-01
Toll Like Receptor 9 (TLR9) Cascade	104	1.02e-01	-0.093000	2.32e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	1.73e-01	-0.092800	3.26e-01
ADORA2B mediated anti-inflammatory cytokines production	34	3.50e-01	-0.092600	5.09e-01
RNA Polymerase I Transcription Initiation	47	2.76e-01	-0.092000	4.36e-01
MAP kinase activation	63	2.08e-01	-0.091700	3.64e-01
mRNA 3’-end processing	57	2.31e-01	-0.091700	3.89e-01
Signal Transduction	2019	2.41e-11	-0.091600	7.84e-10
Chemokine receptors bind chemokines	30	3.88e-01	0.091200	5.42e-01
Negative regulation of MAPK pathway	41	3.14e-01	-0.090900	4.70e-01
Cytochrome P450 - arranged by substrate type	33	3.68e-01	-0.090600	5.25e-01
Uptake and actions of bacterial toxins	24	4.42e-01	-0.090600	5.90e-01
Neurotransmitter receptors and postsynaptic signal transmission	137	6.78e-02	-0.090500	1.75e-01
Mitochondrial protein import	63	2.16e-01	0.090200	3.71e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	4.65e-01	-0.090100	6.11e-01
CTLA4 inhibitory signaling	18	5.09e-01	-0.090000	6.49e-01
Cellular response to chemical stress	184	3.63e-02	-0.089600	1.13e-01
Signaling by Activin	14	5.62e-01	0.089600	6.93e-01
The role of Nef in HIV-1 replication and disease pathogenesis	24	4.48e-01	-0.089500	5.95e-01
VLDLR internalisation and degradation	15	5.49e-01	-0.089300	6.84e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	22	4.69e-01	-0.089300	6.15e-01
Cell-Cell communication	117	9.58e-02	-0.089200	2.24e-01
MTOR signalling	41	3.24e-01	0.089000	4.81e-01
Negative regulators of DDX58/IFIH1 signaling	34	3.70e-01	-0.088900	5.26e-01
Transferrin endocytosis and recycling	27	4.25e-01	-0.088700	5.73e-01
Neddylation	230	2.16e-02	-0.088100	7.43e-02
PKA activation	16	5.42e-01	0.088000	6.79e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	31	3.98e-01	-0.087700	5.49e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	31	3.98e-01	-0.087700	5.49e-01
Nuclear Events (kinase and transcription factor activation)	57	2.53e-01	-0.087600	4.12e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	3.27e-01	-0.087500	4.84e-01
CD28 co-stimulation	30	4.08e-01	0.087400	5.57e-01
Cardiac conduction	93	1.49e-01	0.086600	2.95e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	185	4.27e-02	-0.086500	1.29e-01
Trafficking of GluR2-containing AMPA receptors	14	5.76e-01	0.086400	7.02e-01
Metabolism of vitamins and cofactors	157	6.26e-02	0.086200	1.65e-01
Nucleotide-like (purinergic) receptors	14	5.78e-01	0.085900	7.03e-01
Transport of Mature Transcript to Cytoplasm	81	1.82e-01	-0.085900	3.33e-01
Pre-NOTCH Processing in Golgi	18	5.28e-01	-0.085900	6.67e-01
Interactions of Vpr with host cellular proteins	37	3.66e-01	-0.085800	5.25e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	1.15e-01	0.085800	2.50e-01
TBC/RABGAPs	43	3.34e-01	0.085100	4.91e-01
RIP-mediated NFkB activation via ZBP1	16	5.56e-01	-0.085100	6.88e-01
Plasma lipoprotein clearance	32	4.05e-01	-0.085000	5.55e-01
Interleukin-6 signaling	10	6.43e-01	0.084700	7.51e-01
Signaling by TGFB family members	114	1.20e-01	-0.084500	2.55e-01
CaM pathway	31	4.16e-01	0.084400	5.64e-01
Calmodulin induced events	31	4.16e-01	0.084400	5.64e-01
Respiratory electron transport	93	1.60e-01	0.084400	3.10e-01
G-protein mediated events	49	3.07e-01	-0.084400	4.62e-01
Protein localization	156	6.92e-02	0.084400	1.77e-01
Activation of AMPK downstream of NMDARs	21	5.04e-01	-0.084300	6.45e-01
Notch-HLH transcription pathway	28	4.40e-01	-0.084300	5.88e-01
Signaling by ERBB2 TMD/JMD mutants	18	5.38e-01	-0.083900	6.76e-01
Signaling by Receptor Tyrosine Kinases	461	2.13e-03	-0.083800	1.21e-02
The canonical retinoid cycle in rods (twilight vision)	10	6.47e-01	0.083600	7.54e-01
FLT3 signaling in disease	27	4.53e-01	-0.083500	5.99e-01
MyD88 cascade initiated on plasma membrane	93	1.65e-01	-0.083300	3.16e-01
Toll Like Receptor 10 (TLR10) Cascade	93	1.65e-01	-0.083300	3.16e-01
Toll Like Receptor 5 (TLR5) Cascade	93	1.65e-01	-0.083300	3.16e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	6.04e-01	-0.083100	7.23e-01
Defective EXT2 causes exostoses 2	13	6.04e-01	-0.083100	7.23e-01
Sema3A PAK dependent Axon repulsion	16	5.66e-01	-0.083000	6.95e-01
ATF4 activates genes in response to endoplasmic reticulum stress	27	4.56e-01	-0.082800	6.02e-01
Metabolism of amino acids and derivatives	312	1.25e-02	-0.082400	4.80e-02
Signaling by cytosolic FGFR1 fusion mutants	18	5.46e-01	-0.082300	6.81e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	6.22e-01	-0.082200	7.38e-01
Cargo recognition for clathrin-mediated endocytosis	89	1.82e-01	-0.081900	3.34e-01
CDC42 GTPase cycle	148	8.61e-02	-0.081800	2.08e-01
HDR through MMEJ (alt-NHEJ)	12	6.24e-01	-0.081800	7.39e-01
Attachment and Entry 9694614	15	5.85e-01	-0.081500	7.08e-01
Signaling by FLT3 ITD and TKD mutants	15	5.86e-01	-0.081200	7.08e-01
Paracetamol ADME	19	5.43e-01	0.080600	6.79e-01
Prolactin receptor signaling	10	6.60e-01	0.080300	7.62e-01
Signaling by Insulin receptor	65	2.64e-01	-0.080200	4.22e-01
Toll Like Receptor 3 (TLR3) Cascade	102	1.63e-01	-0.080100	3.14e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	6.32e-01	-0.080000	7.42e-01
Defects in cobalamin (B12) metabolism	12	6.32e-01	-0.079900	7.42e-01
Vasopressin regulates renal water homeostasis via Aquaporins	33	4.28e-01	-0.079800	5.76e-01
Membrane Trafficking	568	1.27e-03	-0.079500	7.88e-03
Translation of Structural Proteins 9694635	57	3.00e-01	-0.079400	4.55e-01
Transcriptional Regulation by TP53	342	1.22e-02	-0.079000	4.72e-02
tRNA Aminoacylation	42	3.76e-01	0.079000	5.32e-01
Semaphorin interactions	63	2.80e-01	-0.078800	4.40e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.13e-01	0.078700	4.70e-01
RAF-independent MAPK1/3 activation	20	5.43e-01	-0.078700	6.79e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	24	5.05e-01	-0.078600	6.46e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	99	1.77e-01	-0.078600	3.29e-01
MyD88-independent TLR4 cascade	106	1.64e-01	-0.078300	3.15e-01
TRIF(TICAM1)-mediated TLR4 signaling	106	1.64e-01	-0.078300	3.15e-01
G-protein beta:gamma signalling	27	4.82e-01	-0.078100	6.25e-01
Signaling by BMP	22	5.27e-01	-0.078000	6.65e-01
Activation of NMDA receptors and postsynaptic events	74	2.48e-01	-0.077700	4.05e-01
Signaling by Interleukins	373	1.03e-02	-0.077600	4.21e-02
NCAM signaling for neurite out-growth	51	3.38e-01	-0.077500	4.95e-01
TAK1-dependent IKK and NF-kappa-B activation	42	3.85e-01	-0.077500	5.40e-01
Cristae formation	29	4.71e-01	0.077400	6.17e-01
Interleukin-17 signaling	66	2.79e-01	-0.077100	4.40e-01
SUMOylation of intracellular receptors	27	4.91e-01	-0.076500	6.33e-01
Miscellaneous transport and binding events	22	5.35e-01	-0.076500	6.74e-01
Downstream signal transduction	28	4.84e-01	-0.076500	6.26e-01
Energy dependent regulation of mTOR by LKB1-AMPK	29	4.77e-01	0.076400	6.21e-01
Elastic fibre formation	41	3.99e-01	0.076200	5.49e-01
Defective B3GAT3 causes JDSSDHD	16	5.98e-01	-0.076100	7.19e-01
Potential therapeutics for SARS	89	2.17e-01	-0.075700	3.72e-01
Lewis blood group biosynthesis	10	6.82e-01	-0.075000	7.82e-01
GPER1 signaling	37	4.30e-01	-0.074900	5.78e-01
MyD88 dependent cascade initiated on endosome	100	1.98e-01	-0.074600	3.52e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	5.76e-01	-0.074100	7.02e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	5.76e-01	-0.074100	7.02e-01
Vesicle-mediated transport	597	2.16e-03	-0.073800	1.22e-02
Diseases associated with glycosaminoglycan metabolism	37	4.39e-01	-0.073500	5.88e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	15	6.23e-01	0.073300	7.39e-01
Keratan sulfate/keratin metabolism	32	4.74e-01	-0.073200	6.19e-01
Basigin interactions	22	5.53e-01	-0.073100	6.85e-01
Mitophagy	28	5.04e-01	-0.073000	6.45e-01
Selective autophagy	71	2.90e-01	-0.072700	4.48e-01
Regulation of FZD by ubiquitination	16	6.16e-01	-0.072500	7.31e-01
Cytokine Signaling in Immune system	574	3.58e-03	-0.071400	1.85e-02
Transcriptional regulation of white adipocyte differentiation	82	2.68e-01	0.070900	4.26e-01
Metabolism of porphyrins	20	5.84e-01	0.070700	7.08e-01
Ovarian tumor domain proteases	35	4.71e-01	-0.070400	6.17e-01
Synthesis of IP3 and IP4 in the cytosol	22	5.69e-01	-0.070200	6.97e-01
DNA methylation	10	7.01e-01	-0.070200	7.99e-01
Membrane binding and targetting of GAG proteins	14	6.50e-01	-0.070100	7.54e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	6.50e-01	-0.070100	7.54e-01
Attenuation phase	22	5.71e-01	-0.069900	6.99e-01
Repression of WNT target genes	14	6.52e-01	0.069600	7.57e-01
HS-GAG biosynthesis	22	5.73e-01	-0.069500	7.01e-01
MicroRNA (miRNA) biogenesis	25	5.51e-01	-0.068900	6.84e-01
HCMV Late Events	59	3.60e-01	-0.068900	5.19e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	101	2.32e-01	-0.068800	3.90e-01
Inactivation of CSF3 (G-CSF) signaling	24	5.60e-01	0.068700	6.92e-01
Processing of Intronless Pre-mRNAs	20	5.97e-01	-0.068200	7.19e-01
Antigen processing: Ubiquitination & Proteasome degradation	289	4.66e-02	-0.068200	1.36e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	27	5.44e-01	-0.067500	6.79e-01
Signaling by NTRKs	122	2.00e-01	-0.067200	3.55e-01
Aquaporin-mediated transport	35	4.94e-01	-0.066800	6.36e-01
Circadian Clock	66	3.49e-01	0.066700	5.08e-01
RUNX3 regulates p14-ARF	10	7.15e-01	0.066600	8.10e-01
Erythropoietin activates RAS	13	6.79e-01	0.066300	7.80e-01
DAP12 signaling	25	5.66e-01	-0.066300	6.95e-01
Activation of G protein gated Potassium channels	18	6.27e-01	-0.066100	7.40e-01
G protein gated Potassium channels	18	6.27e-01	-0.066100	7.40e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	6.27e-01	-0.066100	7.40e-01
Interferon alpha/beta signaling	57	3.91e-01	-0.065800	5.43e-01
Signaling by PDGFR in disease	20	6.11e-01	-0.065700	7.27e-01
Pre-NOTCH Expression and Processing	55	4.02e-01	-0.065400	5.52e-01
Signaling by MET	74	3.33e-01	-0.065100	4.90e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	17	6.47e-01	-0.064200	7.54e-01
Signaling by ALK	27	5.66e-01	0.063900	6.95e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	5.47e-01	-0.063600	6.81e-01
FCGR activation	11	7.15e-01	0.063500	8.10e-01
Cellular response to heat stress	96	2.84e-01	-0.063400	4.44e-01
DNA Damage Recognition in GG-NER	38	5.00e-01	-0.063200	6.42e-01
mTORC1-mediated signalling	24	5.93e-01	-0.063000	7.15e-01
Oxidative Stress Induced Senescence	69	3.69e-01	-0.062600	5.26e-01
Diseases of metabolism	204	1.24e-01	0.062500	2.63e-01
Signaling by Nuclear Receptors	212	1.19e-01	-0.062200	2.55e-01
NGF-stimulated transcription	35	5.25e-01	-0.062200	6.65e-01
NOD1/2 Signaling Pathway	36	5.20e-01	-0.062000	6.61e-01
Non-integrin membrane-ECM interactions	55	4.29e-01	-0.061700	5.77e-01
Ca-dependent events	33	5.42e-01	0.061400	6.79e-01
Diseases of glycosylation	124	2.43e-01	0.060700	4.00e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	65	3.98e-01	-0.060600	5.49e-01
Bile acid and bile salt metabolism	27	5.86e-01	0.060600	7.08e-01
Cytosolic sulfonation of small molecules	18	6.57e-01	-0.060400	7.60e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	6.43e-01	-0.059900	7.51e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	51	4.63e-01	-0.059400	6.09e-01
FCERI mediated Ca+2 mobilization	29	5.80e-01	-0.059400	7.05e-01
Activation of SMO	16	6.82e-01	-0.059200	7.82e-01
Syndecan interactions	26	6.02e-01	-0.059100	7.22e-01
Response to elevated platelet cytosolic Ca2+	110	2.88e-01	-0.058700	4.47e-01
SUMOylation of chromatin organization proteins	57	4.47e-01	-0.058300	5.94e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	84	3.56e-01	0.058300	5.15e-01
Fatty acyl-CoA biosynthesis	30	5.82e-01	-0.058100	7.07e-01
Signaling by RAF1 mutants	36	5.50e-01	-0.057600	6.84e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	7.11e-01	-0.057200	8.06e-01
Chondroitin sulfate biosynthesis	15	7.02e-01	-0.057000	7.99e-01
Activation of GABAB receptors	30	5.90e-01	-0.056900	7.12e-01
GABA B receptor activation	30	5.90e-01	-0.056900	7.12e-01
Platelet Aggregation (Plug Formation)	29	5.97e-01	-0.056800	7.19e-01
Long-term potentiation	18	6.77e-01	0.056700	7.79e-01
MET promotes cell motility	40	5.36e-01	-0.056600	6.75e-01
Signaling by NTRK1 (TRKA)	106	3.16e-01	-0.056500	4.72e-01
Constitutive Signaling by Aberrant PI3K in Cancer	54	4.73e-01	-0.056400	6.19e-01
Opioid Signalling	79	3.86e-01	-0.056400	5.41e-01
Zinc transporters	10	7.59e-01	0.056100	8.43e-01
Metabolism of nucleotides	82	3.81e-01	-0.056000	5.36e-01
Inwardly rectifying K+ channels	22	6.50e-01	-0.056000	7.54e-01
Defective Intrinsic Pathway for Apoptosis	21	6.60e-01	-0.055400	7.62e-01
Mucopolysaccharidoses	11	7.51e-01	0.055300	8.39e-01
Signaling by CSF3 (G-CSF)	29	6.07e-01	0.055200	7.24e-01
Interaction between L1 and Ankyrins	24	6.43e-01	0.054700	7.51e-01
Macroautophagy	124	2.93e-01	-0.054700	4.50e-01
Innate Immune System	834	8.36e-03	-0.054100	3.60e-02
Cholesterol biosynthesis	27	6.27e-01	-0.054100	7.40e-01
ATF6 (ATF6-alpha) activates chaperones	12	7.46e-01	0.053900	8.36e-01
Platelet Adhesion to exposed collagen	11	7.58e-01	-0.053700	8.42e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	7.02e-01	-0.053500	7.99e-01
Ion channel transport	134	2.89e-01	0.053100	4.47e-01
Germ layer formation at gastrulation	11	7.61e-01	-0.053000	8.44e-01
TNFR1-induced proapoptotic signaling	25	6.46e-01	0.053000	7.54e-01
GPCR ligand binding	193	2.06e-01	-0.052900	3.62e-01
Degradation of the extracellular matrix	103	3.57e-01	0.052600	5.15e-01
Caspase activation via extrinsic apoptotic signalling pathway	23	6.67e-01	0.051800	7.69e-01
Intrinsic Pathway of Fibrin Clot Formation	13	7.47e-01	0.051700	8.36e-01
Post-translational protein modification	1182	3.08e-03	-0.051600	1.64e-02
Regulation of IFNG signaling	13	7.49e-01	0.051200	8.38e-01
Autophagy	139	2.98e-01	-0.051100	4.54e-01
p75 NTR receptor-mediated signalling	92	3.97e-01	-0.051100	5.49e-01
Glutamate and glutamine metabolism	11	7.70e-01	0.050900	8.50e-01
Keratan sulfate degradation	13	7.51e-01	-0.050800	8.39e-01
Signaling by ALK fusions and activated point mutants	55	5.17e-01	-0.050500	6.58e-01
Signaling by ALK in cancer	55	5.17e-01	-0.050500	6.58e-01
Platelet degranulation	106	3.71e-01	-0.050400	5.27e-01
VxPx cargo-targeting to cilium	17	7.19e-01	-0.050300	8.13e-01
Metabolism of lipids	601	3.76e-02	0.049900	1.16e-01
Class I MHC mediated antigen processing & presentation	350	1.12e-01	-0.049600	2.47e-01
RUNX2 regulates bone development	27	6.56e-01	0.049500	7.59e-01
Interferon Signaling	166	2.72e-01	-0.049500	4.32e-01
Metabolism of steroid hormones	20	7.02e-01	0.049500	7.99e-01
RET signaling	32	6.30e-01	0.049200	7.42e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	37	6.06e-01	0.049000	7.23e-01
Signaling by PDGFRA extracellular domain mutants	12	7.70e-01	-0.048700	8.50e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	7.70e-01	-0.048700	8.50e-01
PI3K Cascade	32	6.35e-01	0.048500	7.45e-01
SHC1 events in EGFR signaling	10	7.93e-01	-0.048000	8.68e-01
TRAF6 mediated NF-kB activation	22	6.98e-01	-0.047900	7.97e-01
Organelle biogenesis and maintenance	274	1.75e-01	-0.047700	3.26e-01
ECM proteoglycans	61	5.21e-01	-0.047500	6.62e-01
Interleukin-37 signaling	19	7.21e-01	-0.047400	8.13e-01
SHC1 events in ERBB2 signaling	18	7.28e-01	-0.047300	8.19e-01
Costimulation by the CD28 family	49	5.69e-01	0.047000	6.97e-01
Dissolution of Fibrin Clot	10	7.97e-01	-0.046900	8.72e-01
Gene expression (Transcription)	1350	4.44e-03	-0.046700	2.16e-02
Post-translational protein phosphorylation	76	4.84e-01	0.046400	6.27e-01
Plasma lipoprotein assembly, remodeling, and clearance	55	5.53e-01	0.046300	6.85e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	7.93e-01	0.045800	8.68e-01
Signaling by NODAL	14	7.68e-01	-0.045600	8.49e-01
Ion transport by P-type ATPases	42	6.10e-01	0.045500	7.26e-01
Glucagon signaling in metabolic regulation	25	6.94e-01	0.045400	7.95e-01
RAF activation	34	6.49e-01	-0.045100	7.54e-01
Dectin-2 family	13	7.79e-01	0.045000	8.56e-01
Signaling by GPCR	398	1.32e-01	-0.044100	2.73e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	79	5.03e-01	-0.043700	6.45e-01
Regulation of TP53 Expression and Degradation	36	6.53e-01	-0.043400	7.57e-01
PLC beta mediated events	45	6.16e-01	-0.043300	7.31e-01
PKMTs methylate histone lysines	42	6.29e-01	-0.043000	7.42e-01
Adenylate cyclase inhibitory pathway	12	7.97e-01	-0.042800	8.72e-01
Cell surface interactions at the vascular wall	101	4.61e-01	-0.042400	6.08e-01
Extracellular matrix organization	242	2.60e-01	0.042100	4.19e-01
The NLRP3 inflammasome	16	7.76e-01	0.041100	8.55e-01
Metabolism of steroids	118	4.43e-01	0.040900	5.90e-01
Late SARS-CoV-2 Infection Events	66	5.66e-01	-0.040900	6.95e-01
FCERI mediated MAPK activation	31	6.96e-01	-0.040500	7.96e-01
Adaptive Immune System	647	8.10e-02	-0.040400	1.98e-01
Activation of HOX genes during differentiation	65	5.84e-01	-0.039300	7.08e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	65	5.84e-01	-0.039300	7.08e-01
Signaling by NTRK3 (TRKC)	17	7.79e-01	0.039300	8.56e-01
Regulation of TNFR1 signaling	48	6.39e-01	0.039100	7.49e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	7.66e-01	0.038400	8.48e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	8.13e-01	0.037800	8.83e-01
Maturation of nucleoprotein 9683610	11	8.28e-01	0.037800	8.92e-01
TNFR1-induced NF-kappa-B signaling pathway	33	7.09e-01	0.037500	8.06e-01
Fanconi Anemia Pathway	35	7.01e-01	-0.037500	7.99e-01
RNA Polymerase II Transcription	1191	3.12e-02	-0.037400	1.00e-01
Nucleotide salvage	22	7.66e-01	0.036700	8.48e-01
Cell junction organization	88	5.56e-01	-0.036300	6.88e-01
Regulation of PTEN gene transcription	60	6.27e-01	-0.036300	7.40e-01
Cargo concentration in the ER	28	7.40e-01	0.036300	8.30e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	33	7.20e-01	-0.036000	8.13e-01
Glycosphingolipid metabolism	36	7.10e-01	0.035800	8.06e-01
Synthesis of substrates in N-glycan biosythesis	57	6.41e-01	0.035800	7.50e-01
G alpha (12/13) signalling events	70	6.06e-01	-0.035700	7.23e-01
Josephin domain DUBs	10	8.46e-01	-0.035500	9.01e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	107	5.26e-01	-0.035500	6.65e-01
Toll Like Receptor 2 (TLR2) Cascade	107	5.26e-01	-0.035500	6.65e-01
Toll Like Receptor TLR1:TLR2 Cascade	107	5.26e-01	-0.035500	6.65e-01
Toll Like Receptor TLR6:TLR2 Cascade	107	5.26e-01	-0.035500	6.65e-01
Interferon gamma signaling	74	5.99e-01	0.035300	7.20e-01
Assembly and cell surface presentation of NMDA receptors	30	7.38e-01	0.035300	8.28e-01
Peptide ligand-binding receptors	73	6.08e-01	-0.034800	7.24e-01
Metabolism	1727	1.85e-02	0.034600	6.55e-02
Neutrophil degranulation	401	2.39e-01	-0.034400	3.96e-01
Phase I - Functionalization of compounds	66	6.30e-01	-0.034300	7.42e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	8.44e-01	0.034200	9.00e-01
alpha-linolenic acid (ALA) metabolism	11	8.44e-01	0.034200	9.00e-01
Eicosanoid ligand-binding receptors	13	8.31e-01	-0.034200	8.92e-01
Formation of ATP by chemiosmotic coupling	16	8.14e-01	0.033900	8.83e-01
Regulation of TP53 Activity through Methylation	19	7.99e-01	0.033700	8.73e-01
Transport of small molecules	530	1.86e-01	0.033700	3.38e-01
Regulation of TP53 Degradation	35	7.34e-01	-0.033200	8.25e-01
Senescence-Associated Secretory Phenotype (SASP)	55	6.72e-01	-0.033000	7.74e-01
Regulation of MECP2 expression and activity	29	7.60e-01	0.032700	8.44e-01
Negative regulation of the PI3K/AKT network	86	6.00e-01	-0.032700	7.20e-01
Neuronal System	255	3.87e-01	0.031500	5.42e-01
RMTs methylate histone arginines	33	7.54e-01	-0.031500	8.41e-01
Formation of Fibrin Clot (Clotting Cascade)	21	8.03e-01	0.031500	8.76e-01
Vitamin B5 (pantothenate) metabolism	16	8.30e-01	-0.031000	8.92e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	11	8.59e-01	-0.030900	9.10e-01
Death Receptor Signaling	148	5.18e-01	-0.030800	6.60e-01
Defective B4GALT7 causes EDS, progeroid type	16	8.31e-01	-0.030700	8.92e-01
GPCR downstream signalling	358	3.20e-01	-0.030700	4.76e-01
Synaptic adhesion-like molecules	16	8.32e-01	0.030700	8.92e-01
GRB2 events in ERBB2 signaling	12	8.54e-01	-0.030600	9.07e-01
Immune System	1583	4.90e-02	-0.030000	1.38e-01
RA biosynthesis pathway	16	8.36e-01	-0.029900	8.93e-01
Role of phospholipids in phagocytosis	22	8.08e-01	-0.029900	8.79e-01
Toll Like Receptor 4 (TLR4) Cascade	135	5.52e-01	-0.029700	6.85e-01
Ion homeostasis	45	7.31e-01	0.029700	8.22e-01
TP53 Regulates Metabolic Genes	82	6.47e-01	-0.029300	7.54e-01
LGI-ADAM interactions	11	8.67e-01	-0.029200	9.12e-01
Cell recruitment (pro-inflammatory response)	24	8.05e-01	0.029100	8.77e-01
Purinergic signaling in leishmaniasis infection	24	8.05e-01	0.029100	8.77e-01
TRP channels	19	8.27e-01	-0.029000	8.91e-01
Binding and Uptake of Ligands by Scavenger Receptors	32	7.77e-01	0.028900	8.55e-01
Cell-cell junction organization	64	6.90e-01	0.028800	7.91e-01
Regulation of RUNX1 Expression and Activity	18	8.35e-01	-0.028300	8.93e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	29	7.93e-01	0.028200	8.68e-01
Formation of WDR5-containing histone-modifying complexes	42	7.55e-01	0.027800	8.41e-01
Synthesis of glycosylphosphatidylinositol (GPI)	18	8.42e-01	-0.027200	8.99e-01
G alpha (i) signalling events	173	5.39e-01	-0.027100	6.76e-01
Formation of annular gap junctions	11	8.76e-01	-0.027100	9.19e-01
Scavenging by Class A Receptors	16	8.52e-01	0.027000	9.05e-01
Synthesis of bile acids and bile salts	24	8.19e-01	0.027000	8.85e-01
Triglyceride catabolism	16	8.52e-01	0.026900	9.05e-01
Drug ADME	59	7.21e-01	0.026900	8.13e-01
HATs acetylate histones	82	6.75e-01	0.026800	7.77e-01
Activation of Matrix Metalloproteinases	21	8.32e-01	0.026800	8.92e-01
Retrograde transport at the Trans-Golgi-Network	49	7.55e-01	-0.025800	8.41e-01
Insulin receptor signalling cascade	41	7.76e-01	-0.025600	8.55e-01
Class A/1 (Rhodopsin-like receptors)	138	6.04e-01	-0.025600	7.23e-01
Biological oxidations	139	6.06e-01	0.025400	7.23e-01
Toll-like Receptor Cascades	155	5.86e-01	-0.025400	7.08e-01
Complex I biogenesis	51	7.56e-01	0.025100	8.42e-01
O-linked glycosylation	83	6.95e-01	0.024900	7.95e-01
MET activates PTK2 signaling	30	8.18e-01	0.024300	8.84e-01
FCGR3A-mediated IL10 synthesis	35	8.06e-01	-0.024000	8.77e-01
Glycosaminoglycan metabolism	104	6.78e-01	-0.023500	7.80e-01
PKA-mediated phosphorylation of CREB	18	8.64e-01	0.023300	9.12e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	9.00e-01	-0.023000	9.36e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	18	8.66e-01	-0.022900	9.12e-01
Neurodegenerative Diseases	18	8.66e-01	-0.022900	9.12e-01
Transcriptional Regulation by VENTX	38	8.08e-01	-0.022800	8.79e-01
GPVI-mediated activation cascade	31	8.27e-01	-0.022700	8.91e-01
Regulation of KIT signaling	15	8.80e-01	-0.022500	9.22e-01
COPI-mediated anterograde transport	90	7.13e-01	-0.022500	8.08e-01
Molecules associated with elastic fibres	34	8.21e-01	0.022400	8.87e-01
Ras activation upon Ca2+ influx through NMDA receptor	16	8.77e-01	0.022400	9.19e-01
Maturation of spike protein 9694548	37	8.16e-01	-0.022100	8.84e-01
Termination of O-glycan biosynthesis	13	8.92e-01	0.021700	9.30e-01
Transport of vitamins, nucleosides, and related molecules	29	8.42e-01	-0.021300	8.99e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	71	7.61e-01	0.020900	8.44e-01
SUMOylation of transcription cofactors	44	8.11e-01	0.020800	8.81e-01
Unfolded Protein Response (UPR)	90	7.37e-01	0.020500	8.28e-01
Transmission across Chemical Synapses	181	6.35e-01	-0.020500	7.46e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	101	7.28e-01	-0.020100	8.19e-01
Formation of the beta-catenin:TCF transactivating complex	36	8.35e-01	0.020100	8.93e-01
DAG and IP3 signaling	37	8.33e-01	0.020000	8.93e-01
Rab regulation of trafficking	116	7.11e-01	-0.019900	8.06e-01
NRAGE signals death through JNK	56	7.99e-01	0.019600	8.73e-01
Generic Transcription Pathway	1073	2.82e-01	-0.019600	4.42e-01
Generation of second messenger molecules	17	8.91e-01	0.019200	9.30e-01
Metabolic disorders of biological oxidation enzymes	23	8.74e-01	0.019100	9.19e-01
Hyaluronan metabolism	16	8.95e-01	0.019000	9.32e-01
Phase II - Conjugation of compounds	69	7.85e-01	0.019000	8.62e-01
Receptor Mediated Mitophagy	11	9.15e-01	-0.018600	9.46e-01
GAB1 signalosome	13	9.08e-01	-0.018500	9.42e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	8.82e-01	-0.018300	9.23e-01
Chromatin modifying enzymes	202	6.56e-01	0.018200	7.59e-01
Chromatin organization	202	6.56e-01	0.018200	7.59e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	8.52e-01	-0.018000	9.05e-01
CD28 dependent Vav1 pathway	10	9.22e-01	-0.017900	9.50e-01
Post-translational modification: synthesis of GPI-anchored proteins	57	8.17e-01	0.017700	8.84e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	8.56e-01	-0.017500	9.08e-01
Retinoid metabolism and transport	28	8.77e-01	-0.017000	9.19e-01
Cytoprotection by HMOX1	58	8.26e-01	0.016700	8.91e-01
Deactivation of the beta-catenin transactivating complex	39	8.60e-01	-0.016400	9.10e-01
Signaling by Erythropoietin	24	8.93e-01	0.015900	9.30e-01
TP53 Regulates Transcription of Cell Death Genes	40	8.62e-01	-0.015900	9.11e-01
Phospholipid metabolism	177	7.19e-01	0.015700	8.13e-01
Cytosolic tRNA aminoacylation	24	8.96e-01	-0.015400	9.32e-01
WNT5A-dependent internalization of FZD4	14	9.21e-01	0.015400	9.50e-01
RUNX2 regulates osteoblast differentiation	21	9.03e-01	-0.015300	9.38e-01
Adherens junctions interactions	45	8.61e-01	0.015100	9.11e-01
PI3K events in ERBB2 signaling	12	9.28e-01	-0.015000	9.55e-01
Tight junction interactions	17	9.15e-01	0.015000	9.46e-01
Regulation of TP53 Activity through Acetylation	29	8.90e-01	0.014800	9.30e-01
Arachidonic acid metabolism	38	8.75e-01	-0.014700	9.19e-01
Cell death signalling via NRAGE, NRIF and NADE	73	8.30e-01	-0.014500	8.92e-01
Integration of energy metabolism	87	8.17e-01	0.014400	8.84e-01
Transport to the Golgi and subsequent modification	164	7.54e-01	-0.014200	8.41e-01
Amino acids regulate mTORC1	49	8.67e-01	0.013900	9.12e-01
Signaling by PDGF	53	8.63e-01	-0.013700	9.11e-01
ER to Golgi Anterograde Transport	139	7.81e-01	-0.013700	8.58e-01
IRS-related events triggered by IGF1R	39	8.83e-01	-0.013600	9.24e-01
Myogenesis	24	9.09e-01	-0.013500	9.42e-01
Translation of Structural Proteins 9683701	29	9.02e-01	0.013200	9.38e-01
MET activates RAS signaling	11	9.42e-01	0.012600	9.66e-01
SLC transporter disorders	69	8.57e-01	0.012600	9.08e-01
Heme signaling	44	8.87e-01	0.012400	9.27e-01
Signalling to RAS	19	9.28e-01	0.012000	9.55e-01
GABA synthesis, release, reuptake and degradation	11	9.46e-01	-0.011900	9.68e-01
Methylation	13	9.41e-01	-0.011900	9.65e-01
Transcriptional regulation of granulopoiesis	33	9.10e-01	-0.011300	9.42e-01
Integrin cell surface interactions	71	8.74e-01	-0.010900	9.19e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	15	9.42e-01	-0.010800	9.66e-01
Pexophagy	11	9.51e-01	0.010800	9.73e-01
Chondroitin sulfate/dermatan sulfate metabolism	42	9.09e-01	-0.010200	9.42e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	9.17e-01	-0.010200	9.47e-01
IGF1R signaling cascade	40	9.14e-01	0.009820	9.46e-01
Nucleotide catabolism	24	9.35e-01	0.009670	9.60e-01
SUMOylation of immune response proteins	11	9.59e-01	0.008970	9.78e-01
Constitutive Signaling by EGFRvIII	15	9.53e-01	0.008850	9.73e-01
Signaling by EGFRvIII in Cancer	15	9.53e-01	0.008850	9.73e-01
Pyrimidine salvage	10	9.62e-01	-0.008770	9.79e-01
Retrograde neurotrophin signalling	12	9.60e-01	-0.008280	9.79e-01
Sensory perception of taste	15	9.59e-01	0.007740	9.78e-01
Transcriptional Regulation by MECP2	48	9.27e-01	-0.007660	9.55e-01
Visual phototransduction	56	9.30e-01	-0.006740	9.57e-01
HS-GAG degradation	20	9.63e-01	0.006040	9.79e-01
TNF signaling	57	9.38e-01	0.005930	9.63e-01
Sialic acid metabolism	27	9.63e-01	0.005190	9.79e-01
Sensory perception of sweet, bitter, and umami (glutamate) taste	12	9.76e-01	0.005060	9.88e-01
NCAM1 interactions	31	9.61e-01	-0.005040	9.79e-01
Uptake and function of anthrax toxins	11	9.79e-01	0.004600	9.88e-01
A tetrasaccharide linker sequence is required for GAG synthesis	20	9.75e-01	-0.004000	9.88e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	18	9.79e-01	0.003610	9.88e-01
P2Y receptors	10	9.84e-01	0.003600	9.90e-01
Cardiogenesis	19	9.79e-01	0.003550	9.88e-01
Signaling by ERBB2 ECD mutants	16	9.83e-01	-0.003080	9.90e-01
CD209 (DC-SIGN) signaling	20	9.81e-01	0.003020	9.89e-01
COPII-mediated vesicle transport	63	9.67e-01	-0.002970	9.83e-01
Metabolism of fat-soluble vitamins	31	9.78e-01	-0.002880	9.88e-01
DAP12 interactions	32	9.78e-01	0.002830	9.88e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	41	9.75e-01	-0.002810	9.88e-01
G alpha (s) signalling events	86	9.68e-01	-0.002490	9.83e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	9.79e-01	-0.002370	9.88e-01
Purine salvage	13	9.88e-01	0.002330	9.93e-01
Transcriptional Regulation by NPAS4	29	9.88e-01	-0.001670	9.93e-01
PI3K/AKT Signaling in Cancer	81	9.82e-01	-0.001460	9.89e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	9.93e-01	0.001260	9.95e-01
Regulation of TP53 Activity through Association with Co-factors	11	9.95e-01	-0.001090	9.95e-01
N-Glycan antennae elongation	13	9.95e-01	-0.000998	9.95e-01
Heparan sulfate/heparin (HS-GAG) metabolism	40	9.92e-01	0.000918	9.95e-01
IRS-mediated signalling	36	9.93e-01	0.000816	9.95e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	56	9.94e-01	0.000608	9.95e-01
Asparagine N-linked glycosylation	275	9.94e-01	-0.000273	9.95e-01

---

Detailed Gene set reports

Folding of actin by CCT/TriC

Folding of actin by CCT/TriC

	405
set	Folding of actin by CCT/TriC
setSize	10
pANOVA	0.000212
s.dist	-0.676
p.adjustANOVA	0.00149

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCT6A	-7835
CCT8	-7822
CCT5	-7705
CCT4	-7458
CCT3	-6305
CCT7	-5034
TCP1	-4679
CCT2	-3808
ACTB	-3660
CCT6B	-363

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCT6A	-7835
CCT8	-7822
CCT5	-7705
CCT4	-7458
CCT3	-6305
CCT7	-5034
TCP1	-4679
CCT2	-3808
ACTB	-3660
CCT6B	-363

---

Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion

	367
set	Establishment of Sister Chromatid Cohesion
setSize	11
pANOVA	0.000202
s.dist	-0.647
p.adjustANOVA	0.00143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMC3	-7968
PDS5A	-7949
PDS5B	-7478
RAD21	-7380
SMC1A	-7240
STAG2	-6684
CDCA5	-6245
ESCO2	-3783
ESCO1	-1279
WAPL	-995
STAG1	-492

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMC3	-7968
PDS5A	-7949
PDS5B	-7478
RAD21	-7380
SMC1A	-7240
STAG2	-6684
CDCA5	-6245
ESCO2	-3783
ESCO1	-1279
WAPL	-995
STAG1	-492

---

mitochondrial fatty acid beta-oxidation of saturated fatty acids

mitochondrial fatty acid beta-oxidation of saturated fatty acids

	1443
set	mitochondrial fatty acid beta-oxidation of saturated fatty acids
setSize	10
pANOVA	0.000441
s.dist	0.642
p.adjustANOVA	0.00301

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACADVL	8067
HADHB	7876
ACADS	7523
HADH	7368
ACADM	6374
ECHS1	6109
HADHA	4282
MECR	4102
ACADL	2916
ACSM3	-1020

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACADVL	8067
HADHB	7876
ACADS	7523
HADH	7368
ACADM	6374
ECHS1	6109
HADHA	4282
MECR	4102
ACADL	2916
ACSM3	-1020

---

Biotin transport and metabolism

Biotin transport and metabolism

	120
set	Biotin transport and metabolism
setSize	11
pANOVA	0.00105
s.dist	0.571
p.adjustANOVA	0.00668

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC5A6	8046
HLCS	6762
MCCC1	6519
MCCC2	6115
PCCB	5384
PC	5383
ACACB	4540
PCCA	4231
PDZD11	3167
BTD	1997
ACACA	391

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC5A6	8046
HLCS	6762
MCCC1	6519
MCCC2	6115
PCCB	5384
PC	5383
ACACB	4540
PCCA	4231
PDZD11	3167
BTD	1997
ACACA	391

---

Cohesin Loading onto Chromatin

Cohesin Loading onto Chromatin

	205
set	Cohesin Loading onto Chromatin
setSize	10
pANOVA	0.00192
s.dist	-0.567
p.adjustANOVA	0.011

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMC3	-7968
PDS5A	-7949
PDS5B	-7478
RAD21	-7380
SMC1A	-7240
NIPBL	-7167
STAG2	-6684
WAPL	-995
STAG1	-492
MAU2	7694

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMC3	-7968
PDS5A	-7949
PDS5B	-7478
RAD21	-7380
SMC1A	-7240
NIPBL	-7167
STAG2	-6684
WAPL	-995
STAG1	-492
MAU2	7694

---

Gluconeogenesis

Gluconeogenesis

	481
set	Gluconeogenesis
setSize	29
pANOVA	1.71e-07
s.dist	0.561
p.adjustANOVA	1.84e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ENO3	8303
PGAM2	8277
GOT1	8007
GPI	7875
ALDOA	7860
SLC37A4	7789
ENO2	7499
MDH2	7319
ALDOC	6964
GOT2	6952
GAPDH	6474
PCK1	6390
TPI1	6372
SLC25A12	6342
MDH1	5939
PC	5383
PGK1	5215
SLC25A11	4421
ENO1	4254
SLC25A10	4128

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ENO3	8303
PGAM2	8277
GOT1	8007
GPI	7875
ALDOA	7860
SLC37A4	7789
ENO2	7499
MDH2	7319
ALDOC	6964
GOT2	6952
GAPDH	6474
PCK1	6390
TPI1	6372
SLC25A12	6342
MDH1	5939
PC	5383
PGK1	5215
SLC25A11	4421
ENO1	4254
SLC25A10	4128
SLC37A2	3931
FBP1	3194
FBP2	2834
SLC25A1	2787
PGAM1	1548
PCK2	1207
SLC37A1	-3217
SLC25A13	-3429
G6PC3	-4605

---

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

	187
set	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize	12
pANOVA	0.000813
s.dist	-0.558
p.adjustANOVA	0.00523

Top enriched genes

Top 20 genes

GeneID	Gene Rank
YWHAQ	-7880
CDK1	-7833
YWHAB	-7763
SFN	-7609
YWHAZ	-7036
CCNB1	-6935
WEE1	-5724
CHEK1	-5411
YWHAH	-5079
YWHAE	-1322
YWHAG	3366
CHEK2	5271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
YWHAQ	-7880
CDK1	-7833
YWHAB	-7763
SFN	-7609
YWHAZ	-7036
CCNB1	-6935
WEE1	-5724
CHEK1	-5411
YWHAH	-5079
YWHAE	-1322
YWHAG	3366
CHEK2	5271

---

Somitogenesis

Somitogenesis

	1245
set	Somitogenesis
setSize	50
pANOVA	1.14e-11
s.dist	-0.555
p.adjustANOVA	4.26e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
DLL1	-6951
PSMB9	-6862
NOTCH1	-6811
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
DLL1	-6951
PSMB9	-6862
NOTCH1	-6811
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
CTNNB1	-6185
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
PSMD4	-5136
PSMD1	-5092
EPHA4	-4977
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
PSMC4	-3765
PSME2	-3703
RBPJ	-3440
PSME3	-2988
LFNG	-1679
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
LEF1	465
PSMD3	979
PSMB5	2441
TBX6	2949

---

Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

	1061
set	Regulation of ornithine decarboxylase (ODC)
setSize	48
pANOVA	2.96e-11
s.dist	-0.555
p.adjustANOVA	9.4e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
ODC1	-6952
NQO1	-6940
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
ODC1	-6952
NQO1	-6940
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
AZIN1	-5932
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
PSMC4	-3765
PSME2	-3703
PSME3	-2988
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
OAZ2	-570
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
OAZ1	1278
PSME4	1454
PSMB5	2441

---

Glycogen breakdown (glycogenolysis)

Glycogen breakdown (glycogenolysis)

	489
set	Glycogen breakdown (glycogenolysis)
setSize	14
pANOVA	0.000385
s.dist	0.548
p.adjustANOVA	0.00266

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PHKA1	8194
PHKG1	8127
PGM1	8125
AGL	7987
PYGL	7796
GYG2	7747
PHKA2	7420
GYG1	5718
PHKG2	4628
PHKB	3982
GAA	3296
PYGM	2859
PYGB	-3663
CALM1	-7981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PHKA1	8194
PHKG1	8127
PGM1	8125
AGL	7987
PYGL	7796
GYG2	7747
PHKA2	7420
GYG1	5718
PHKG2	4628
PHKB	3982
GAA	3296
PYGM	2859
PYGB	-3663
CALM1	-7981

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

	1047
set	Regulation of activated PAK-2p34 by proteasome mediated degradation
setSize	48
pANOVA	5.25e-11
s.dist	-0.547
p.adjustANOVA	1.54e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PAK2	-4040
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441

---

Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling

	762
set	Negative regulation of NOTCH4 signaling
setSize	54
pANOVA	8.43e-12
s.dist	-0.537
p.adjustANOVA	3.52e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
YWHAZ	-7036
PSMC3	-6991
NOTCH4	-6965
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
YWHAZ	-7036
PSMC3	-6991
NOTCH4	-6965
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
FBXW7	-4222
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
TACC3	-3186
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSMB5	2441
AKT1	5290

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

	1113
set	SLBP independent Processing of Histone Pre-mRNAs
setSize	10
pANOVA	0.00365
s.dist	-0.531
p.adjustANOVA	0.0188

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNRPF	-7820
SNRPG	-7341
SNRPE	-7333
SNRPB	-6803
ZNF473	-6225
LSM10	-3543
SNRPD3	-3041
LSM11	-1179
NCBP1	-910
NCBP2	1477

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNRPF	-7820
SNRPG	-7341
SNRPE	-7333
SNRPB	-6803
ZNF473	-6225
LSM10	-3543
SNRPD3	-3041
LSM11	-1179
NCBP1	-910
NCBP2	1477

---

Autodegradation of the E3 ubiquitin ligase COP1

Autodegradation of the E3 ubiquitin ligase COP1

	100
set	Autodegradation of the E3 ubiquitin ligase COP1
setSize	49
pANOVA	1.57e-10
s.dist	-0.528
p.adjustANOVA	3.55e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
TP53	-7057
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
TP53	-7057
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
ATM	6341

---

Ubiquitin-dependent degradation of Cyclin D

Ubiquitin-dependent degradation of Cyclin D

	1400
set	Ubiquitin-dependent degradation of Cyclin D
setSize	50
pANOVA	1.11e-10
s.dist	-0.527
p.adjustANOVA	2.88e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
GSK3B	-3036
PSME3	-2988
UBB	-2299
PSMD11	-1599
CCND1	-1484
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
CDK4	3
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441

---

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

	1399
set	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
setSize	49
pANOVA	1.76e-10
s.dist	-0.527
p.adjustANOVA	3.78e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
CHEK1	-5411
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
CHEK2	5271

---

p53-Independent DNA Damage Response

p53-Independent DNA Damage Response

	1448
set	p53-Independent DNA Damage Response
setSize	49
pANOVA	1.76e-10
s.dist	-0.527
p.adjustANOVA	3.78e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
CHEK1	-5411
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
CHEK2	5271

---

p53-Independent G1/S DNA damage checkpoint

p53-Independent G1/S DNA damage checkpoint

	1449
set	p53-Independent G1/S DNA damage checkpoint
setSize	49
pANOVA	1.76e-10
s.dist	-0.527
p.adjustANOVA	3.78e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
CHEK1	-5411
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
CHEK2	5271

---

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

	460
set	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
setSize	52
pANOVA	5.15e-11
s.dist	-0.526
p.adjustANOVA	1.54e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
NFE2L2	-6618
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
NFE2L2	-6618
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
GSK3B	-3036
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSMB5	2441
BTRC	6801

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	1112
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.00269
s.dist	-0.523
p.adjustANOVA	0.0146

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SNRPF	-7820
SNRPG	-7341
SNRPE	-7333
SNRPB	-6803
ZNF473	-6225
LSM10	-3543
SLBP	-3526
SNRPD3	-3041
LSM11	-1179
NCBP1	-910
NCBP2	1477

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SNRPF	-7820
SNRPG	-7341
SNRPE	-7333
SNRPB	-6803
ZNF473	-6225
LSM10	-3543
SLBP	-3526
SNRPD3	-3041
LSM11	-1179
NCBP1	-910
NCBP2	1477

---

Vpu mediated degradation of CD4

Vpu mediated degradation of CD4

	1420
set	Vpu mediated degradation of CD4
setSize	50
pANOVA	3.32e-10
s.dist	-0.514
p.adjustANOVA	6.48e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
CD4	-289
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
BTRC	6801

---

Vif-mediated degradation of APOBEC3G

Vif-mediated degradation of APOBEC3G

	1412
set	Vif-mediated degradation of APOBEC3G
setSize	52
pANOVA	2.21e-10
s.dist	-0.509
p.adjustANOVA	4.55e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
ELOC	-4414
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
ELOB	-2901
UBB	-2299
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
CUL5	-774
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
APOBEC3G	4274

---

SCF-beta-TrCP mediated degradation of Emi1

SCF-beta-TrCP mediated degradation of Emi1

	1102
set	SCF-beta-TrCP mediated degradation of Emi1
setSize	53
pANOVA	1.51e-10
s.dist	-0.508
p.adjustANOVA	3.51e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
CDC20	-5226
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
FBXO5	-4740
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
FZR1	1181
PSME4	1454
PSMB5	2441
BTRC	6801

---

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

	378
set	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
setSize	53
pANOVA	1.89e-10
s.dist	-0.506
p.adjustANOVA	4e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
FBXL18	-7324
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
FBXL18	-7324
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
FBXL7	3862
AURKA	3872

---

Leading Strand Synthesis

Leading Strand Synthesis

	631
set	Leading Strand Synthesis
setSize	14
pANOVA	0.00108
s.dist	-0.505
p.adjustANOVA	0.0068

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFC5	-7828
RFC1	-7827
POLD3	-7394
RFC3	-6985
PRIM2	-6882
PRIM1	-6599
POLD2	-6191
RFC2	-5605
PCNA	-5460
POLA1	-4594
RFC4	-1657
POLA2	-509
POLD4	5157
POLD1	5603

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFC5	-7828
RFC1	-7827
POLD3	-7394
RFC3	-6985
PRIM2	-6882
PRIM1	-6599
POLD2	-6191
RFC2	-5605
PCNA	-5460
POLA1	-4594
RFC4	-1657
POLA2	-509
POLD4	5157
POLD1	5603

---

Polymerase switching

Polymerase switching

	876
set	Polymerase switching
setSize	14
pANOVA	0.00108
s.dist	-0.505
p.adjustANOVA	0.0068

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFC5	-7828
RFC1	-7827
POLD3	-7394
RFC3	-6985
PRIM2	-6882
PRIM1	-6599
POLD2	-6191
RFC2	-5605
PCNA	-5460
POLA1	-4594
RFC4	-1657
POLA2	-509
POLD4	5157
POLD1	5603

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFC5	-7828
RFC1	-7827
POLD3	-7394
RFC3	-6985
PRIM2	-6882
PRIM1	-6599
POLD2	-6191
RFC2	-5605
PCNA	-5460
POLA1	-4594
RFC4	-1657
POLA2	-509
POLD4	5157
POLD1	5603

---

Hh mutants abrogate ligand secretion

Hh mutants abrogate ligand secretion

	528
set	Hh mutants abrogate ligand secretion
setSize	55
pANOVA	1.24e-10
s.dist	-0.501
p.adjustANOVA	3.07e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
DHH	-6919
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
DHH	-6919
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
DERL2	-5962
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
ERLEC1	-4728
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
HHAT	-3820
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
SEL1L	-2282
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
VCP	997
PSME4	1454
OS9	1461
PSMB5	2441
SYVN1	7237

---

Mitotic Telophase/Cytokinesis

Mitotic Telophase/Cytokinesis

	717
set	Mitotic Telophase/Cytokinesis
setSize	13
pANOVA	0.00175
s.dist	-0.501
p.adjustANOVA	0.0102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SMC3	-7968
PDS5A	-7949
PDS5B	-7478
RAD21	-7380
SMC1A	-7240
NIPBL	-7167
STAG2	-6684
KIF23	-4730
KIF20A	-3592
WAPL	-995
STAG1	-492
PLK1	1596
MAU2	7694

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SMC3	-7968
PDS5A	-7949
PDS5B	-7478
RAD21	-7380
SMC1A	-7240
NIPBL	-7167
STAG2	-6684
KIF23	-4730
KIF20A	-3592
WAPL	-995
STAG1	-492
PLK1	1596
MAU2	7694

---

Beta-oxidation of very long chain fatty acids

Beta-oxidation of very long chain fatty acids

	113
set	Beta-oxidation of very long chain fatty acids
setSize	10
pANOVA	0.00618
s.dist	0.5
p.adjustANOVA	0.028

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MLYCD	8033
ACOT8	7446
ACAA1	6812
ABCD1	5791
ECI2	5043
ACOT4	4303
ACOX1	3220
HSD17B4	824
EHHADH	363
DECR2	125

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MLYCD	8033
ACOT8	7446
ACAA1	6812
ABCD1	5791
ECI2	5043
ACOT4	4303
ACOX1	3220
HSD17B4	824
EHHADH	363
DECR2	125

---

Regulation of Apoptosis

Regulation of Apoptosis

	1010
set	Regulation of Apoptosis
setSize	51
pANOVA	7.25e-10
s.dist	-0.499
p.adjustANOVA	1.22e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PAK2	-4040
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
OPA1	782
PSMD3	979
ARHGAP10	1373
PSME4	1454
PSMB5	2441
OMA1	5119

---

Hh mutants are degraded by ERAD

Hh mutants are degraded by ERAD

	529
set	Hh mutants are degraded by ERAD
setSize	53
pANOVA	4.44e-10
s.dist	-0.495
p.adjustANOVA	8.22e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
DERL2	-5962
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
ERLEC1	-4728
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBB	-2299
SEL1L	-2282
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
VCP	997
PSME4	1454
OS9	1461
PSMB5	2441
SYVN1	7237

---

Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)

	229
set	Cross-presentation of soluble exogenous antigens (endosomes)
setSize	46
pANOVA	7.18e-09
s.dist	-0.493
p.adjustANOVA	9.13e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
PSMC4	-3765
PSME2	-3703
PSME3	-2988
PSMD11	-1599
PSMD8	-1257
PSMD2	-793
PSMB2	-704
PSMD9	-564
MRC1	-398
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
MRC2	5798
FCGR1A	7544

---

Degradation of GLI1 by the proteasome

Degradation of GLI1 by the proteasome

	286
set	Degradation of GLI1 by the proteasome
setSize	57
pANOVA	1.41e-10
s.dist	-0.491
p.adjustANOVA	3.37e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
GLI1	-7244
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
GLI1	-7244
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
ITCH	-6124
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PRKACB	-5130
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
SUFU	-3047
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
NUMB	-372
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
PRKACA	6159
BTRC	6801

---

APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of mitotic proteins

	16
set	APC/C:Cdc20 mediated degradation of mitotic proteins
setSize	73
pANOVA	4.32e-13
s.dist	-0.49
p.adjustANOVA	2.75e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
NEK2	-7970
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
CCNB1	-6935
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
NEK2	-7970
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
CCNB1	-6935
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662
PSMD13	-6654
ANAPC4	-6534
CDC23	-6517
ANAPC15	-6429
CDC26	-6409
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
UBE2S	-5879
PSMD6	-5833
PSMB6	-5713
CCNA2	-5697
PSMB3	-5270
MAD2L1	-5244
CDC20	-5226
BUB1B	-5194
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
UBE2C	-4906
BUB3	-4737
PSMB8	-4559
CDC27	-4453
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
PTTG1	-2813
UBE2E1	-2575
UBB	-2299
PSMD11	-1599
ANAPC7	-1585
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
ANAPC10	-590
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
ANAPC11	1108
PSME4	1454
ANAPC16	2210
PSMB5	2441
CDC16	4034
ANAPC5	4238
UBE2D1	5911
ANAPC2	7492

---

Orc1 removal from chromatin

Orc1 removal from chromatin

	808
set	Orc1 removal from chromatin
setSize	67
pANOVA	4.76e-12
s.dist	-0.488
p.adjustANOVA	2.11e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
MCM3	-7422
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
ORC5	-6990
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
MCM3	-7422
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
ORC5	-6990
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
ORC4	-6067
ORC6	-5888
PSMD6	-5833
PSMB6	-5713
CCNA2	-5697
SKP1	-5412
PSMB3	-5270
MCM8	-5169
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
ORC2	-4736
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
MCM4	-4029
PSMC4	-3765
PSME2	-3703
CDC6	-3469
PSME3	-2988
MCM6	-2661
CDT1	-2356
UBB	-2299
MCM2	-2118
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
MCM5	-1073
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
CDK2	1755
PSMB5	2441
SKP2	2843
ORC3	2974
MCM7	3568

---

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

	18
set	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
setSize	71
pANOVA	1.28e-12
s.dist	-0.487
p.adjustANOVA	7.18e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
NEK2	-7970
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662
PSMD13	-6654

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
NEK2	-7970
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662
PSMD13	-6654
ANAPC4	-6534
CDC23	-6517
ANAPC15	-6429
CDC26	-6409
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
UBE2S	-5879
PSMD6	-5833
PSMB6	-5713
CCNA2	-5697
PSMB3	-5270
MAD2L1	-5244
CDC20	-5226
BUB1B	-5194
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
UBE2C	-4906
BUB3	-4737
PSMB8	-4559
CDC27	-4453
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBE2E1	-2575
UBB	-2299
PSMD11	-1599
ANAPC7	-1585
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
ANAPC10	-590
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
ANAPC11	1108
PSME4	1454
ANAPC16	2210
PSMB5	2441
CDC16	4034
ANAPC5	4238
UBE2D1	5911
ANAPC2	7492

---

AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

	22
set	AUF1 (hnRNP D0) binds and destabilizes mRNA
setSize	53
pANOVA	1.15e-09
s.dist	-0.483
p.adjustANOVA	1.81e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
HSPA8	-4814
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
HNRNPD	-2574
UBB	-2299
PSMD11	-1599
PSMD8	-1257
HSPB1	-1099
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PABPC1	292
PSMD3	979
PSME4	1454
PSMB5	2441
HSPA1A	3441
EIF4G1	6679

---

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

	33
set	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
setSize	74
pANOVA	8.12e-13
s.dist	-0.481
p.adjustANOVA	4.75e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
NEK2	-7970
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
CCNB1	-6935
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
NEK2	-7970
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
CCNB1	-6935
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662
PSMD13	-6654
ANAPC4	-6534
CDC23	-6517
ANAPC15	-6429
CDC26	-6409
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
UBE2S	-5879
PSMD6	-5833
PSMB6	-5713
CCNA2	-5697
PSMB3	-5270
MAD2L1	-5244
CDC20	-5226
BUB1B	-5194
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
UBE2C	-4906
BUB3	-4737
PSMB8	-4559
CDC27	-4453
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
PTTG1	-2813
UBE2E1	-2575
UBB	-2299
PSMD11	-1599
ANAPC7	-1585
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
ANAPC10	-590
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
ANAPC11	1108
PSME4	1454
PLK1	1596
ANAPC16	2210
PSMB5	2441
CDC16	4034
ANAPC5	4238
UBE2D1	5911
ANAPC2	7492

---

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

	164
set	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
setSize	70
pANOVA	3.83e-12
s.dist	-0.48
p.adjustANOVA	1.81e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662
PSMD13	-6654
ANAPC4	-6534

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
CDK1	-7833
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
ANAPC1	-6828
PSMC6	-6662
PSMD13	-6654
ANAPC4	-6534
CDC23	-6517
ANAPC15	-6429
CDC26	-6409
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
UBE2S	-5879
PSMD6	-5833
PSMB6	-5713
CCNA2	-5697
PSMB3	-5270
MAD2L1	-5244
CDC20	-5226
BUB1B	-5194
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
UBE2C	-4906
BUB3	-4737
PSMB8	-4559
CDC27	-4453
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
UBE2E1	-2575
UBB	-2299
PSMD11	-1599
ANAPC7	-1585
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
ANAPC10	-590
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
ANAPC11	1108
PSME4	1454
ANAPC16	2210
PSMB5	2441
CDC16	4034
ANAPC5	4238
UBE2D1	5911
ANAPC2	7492

---

Branched-chain amino acid catabolism

Branched-chain amino acid catabolism

	122
set	Branched-chain amino acid catabolism
setSize	21
pANOVA	0.000151
s.dist	0.478
p.adjustANOVA	0.00111

Top enriched genes

Top 20 genes

GeneID	Gene Rank
BCAT2	7776
BCKDK	7582
ACAD8	7168
ALDH6A1	6932
MCCC1	6519
HIBADH	6317
MCCC2	6115
ECHS1	6109
DLD	5515
ACAT1	5367
AUH	5092
ACADSB	4832
HIBCH	4497
BCKDHA	4414
SLC25A44	4246
BCAT1	3019
IVD	2131
DBT	1554
BCKDHB	-1272
PPM1K	-2248

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
BCAT2	7776
BCKDK	7582
ACAD8	7168
ALDH6A1	6932
MCCC1	6519
HIBADH	6317
MCCC2	6115
ECHS1	6109
DLD	5515
ACAT1	5367
AUH	5092
ACADSB	4832
HIBCH	4497
BCKDHA	4414
SLC25A44	4246
BCAT1	3019
IVD	2131
DBT	1554
BCKDHB	-1272
PPM1K	-2248
HSD17B10	-7466

---

GLI3 is processed to GLI3R by the proteasome

GLI3 is processed to GLI3R by the proteasome

	453
set	GLI3 is processed to GLI3R by the proteasome
setSize	57
pANOVA	5.02e-10
s.dist	-0.476
p.adjustANOVA	8.95e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
CSNK1A1	-8028
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
CSNK1A1	-8028
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PRKACB	-5130
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
SUFU	-3047
GSK3B	-3036
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
GLI3	4347
PRKACA	6159
BTRC	6801

---

Regulation of pyruvate dehydrogenase (PDH) complex

Regulation of pyruvate dehydrogenase (PDH) complex

	1062
set	Regulation of pyruvate dehydrogenase (PDH) complex
setSize	15
pANOVA	0.00143
s.dist	0.475
p.adjustANOVA	0.00868

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PDK2	8154
PDK4	8030
PPARD	7954
PDHA1	7007
PDHX	6875
PDPR	6678
DLD	5515
GSTZ1	4617
PDK1	3618
DLAT	2838
RXRA	1676
PDP1	1540
PDHB	1182
PDK3	-2228
PDP2	-3561

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PDK2	8154
PDK4	8030
PPARD	7954
PDHA1	7007
PDHX	6875
PDPR	6678
DLD	5515
GSTZ1	4617
PDK1	3618
DLAT	2838
RXRA	1676
PDP1	1540
PDHB	1182
PDK3	-2228
PDP2	-3561

---

Regulation of RAS by GAPs

Regulation of RAS by GAPs

	1033
set	Regulation of RAS by GAPs
setSize	65
pANOVA	3.59e-11
s.dist	-0.475
p.adjustANOVA	1.12e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRAS	-8103
PSMC1	-8029
RASAL2	-7901
PSMA6	-7895
PSMD7	-7814
SPRED1	-7722
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRAS	-8103
PSMC1	-8029
RASAL2	-7901
PSMA6	-7895
PSMD7	-7814
SPRED1	-7722
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
NRAS	-5485
RASA2	-5381
SPRED2	-5366
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
RASA4	-3844
PSMC4	-3765
KBTBD7	-3750
PSME2	-3703
NF1	-3409
PSME3	-2988
DAB2IP	-2720
HRAS	-2524
UBB	-2299
CUL3	-1613
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
RASAL3	-731
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
RASA1	2657
SYNGAP1	5455
RASA3	5817
SPRED3	6031

---

Regulation of RUNX3 expression and activity

Regulation of RUNX3 expression and activity

	1036
set	Regulation of RUNX3 expression and activity
setSize	55
pANOVA	1.24e-09
s.dist	-0.473
p.adjustANOVA	1.9e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
CBFB	-6712
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
CBFB	-6712
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
PSME3	-2988
RUNX3	-2392
UBB	-2299
PSMD11	-1599
PSMD8	-1257
MDM2	-1124
SRC	-1089
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
SMURF1	295
TGFB1	567
SMURF2	731
PSMD3	979
PSMB5	2441
EP300	4369
CDKN2A	5415

---

Downstream signaling events of B Cell Receptor (BCR)

Downstream signaling events of B Cell Receptor (BCR)

	328
set	Downstream signaling events of B Cell Receptor (BCR)
setSize	78
pANOVA	5.29e-13
s.dist	-0.473
p.adjustANOVA	3.22e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRAS	-8103
PSMC1	-8029
NFATC2	-7999
CALM1	-7981
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
FKBP1A	-7327
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PPIA	-7136
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PRKCB	-6967

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRAS	-8103
PSMC1	-8029
NFATC2	-7999
CALM1	-7981
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
FKBP1A	-7327
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PPIA	-7136
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PRKCB	-6967
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
BCL10	-6274
PPP3CA	-5968
PSMD6	-5833
PSMB6	-5713
NRAS	-5485
NFKBIA	-5413
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
RASGRP3	-5107
PSMD1	-5092
PSMC2	-4975
CHUK	-4800
NFKBIB	-4784
CARD11	-4642
PSMB8	-4559
PSMA7	-4277
MAP3K7	-4213
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
NFATC1	-3525
PSME3	-2988
FBXW11	-2704
HRAS	-2524
UBB	-2299
REL	-1859
CUL1	-1621
PSMD11	-1599
MALT1	-1353
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
NFKB1	-440
PSMD5	-373
PSMB10	-283
PSMD12	-123
NFATC3	-41
NFKBIE	-3
PSMF1	64
PPP3R1	205
PSMD3	979
PSME4	1454
IKBKB	2334
PSMB5	2441
RELA	4123
IKBKG	4328
PPP3CB	6300
BTRC	6801

---

Striated Muscle Contraction

Striated Muscle Contraction

	1251
set	Striated Muscle Contraction
setSize	32
pANOVA	3.88e-06
s.dist	0.472
p.adjustANOVA	3.48e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYL3	8307
TNNI2	8305
TMOD4	8295
DES	8264
TNNT3	8262
MYH6	8092
MYH3	8015
TPM3	7927
TPM2	7543
TMOD1	6250
DMD	5979
MYBPC3	5343
MYL2	4976
TNNC1	4763
TPM1	4630
TNNI1	4425
MYBPC2	3971
ACTN3	3752
TNNT1	3460
MYBPC1	3428

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYL3	8307
TNNI2	8305
TMOD4	8295
DES	8264
TNNT3	8262
MYH6	8092
MYH3	8015
TPM3	7927
TPM2	7543
TMOD1	6250
DMD	5979
MYBPC3	5343
MYL2	4976
TNNC1	4763
TPM1	4630
TNNI1	4425
MYBPC2	3971
ACTN3	3752
TNNT1	3460
MYBPC1	3428
MYL1	3421
NEB	3338
TCAP	3116
TTN	2874
ACTA1	2550
TNNC2	2332
ACTN2	2251
TMOD2	814
ACTC1	-1249
TPM4	-1464
VIM	-7204
TMOD3	-8130

---

Constitutive Signaling by NOTCH1 HD Domain Mutants

Constitutive Signaling by NOTCH1 HD Domain Mutants

	220
set	Constitutive Signaling by NOTCH1 HD Domain Mutants
setSize	15
pANOVA	0.00157
s.dist	-0.471
p.adjustANOVA	0.00932

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NEURL1B	-7547
ADAM10	-7533
DLL4	-7331
JAG2	-7134
DLL1	-6951
NOTCH1	-6811
JAG1	-6395
ADAM17	-6284
UBC	-5168
MIB1	-4632
RPS27A	-4208
UBB	-2299
UBA52	-616
NEURL1	7977
MIB2	8203

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NEURL1B	-7547
ADAM10	-7533
DLL4	-7331
JAG2	-7134
DLL1	-6951
NOTCH1	-6811
JAG1	-6395
ADAM17	-6284
UBC	-5168
MIB1	-4632
RPS27A	-4208
UBB	-2299
UBA52	-616
NEURL1	7977
MIB2	8203

---

Signaling by NOTCH1 HD Domain Mutants in Cancer

Signaling by NOTCH1 HD Domain Mutants in Cancer

	1204
set	Signaling by NOTCH1 HD Domain Mutants in Cancer
setSize	15
pANOVA	0.00157
s.dist	-0.471
p.adjustANOVA	0.00932

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NEURL1B	-7547
ADAM10	-7533
DLL4	-7331
JAG2	-7134
DLL1	-6951
NOTCH1	-6811
JAG1	-6395
ADAM17	-6284
UBC	-5168
MIB1	-4632
RPS27A	-4208
UBB	-2299
UBA52	-616
NEURL1	7977
MIB2	8203

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NEURL1B	-7547
ADAM10	-7533
DLL4	-7331
JAG2	-7134
DLL1	-6951
NOTCH1	-6811
JAG1	-6395
ADAM17	-6284
UBC	-5168
MIB1	-4632
RPS27A	-4208
UBB	-2299
UBA52	-616
NEURL1	7977
MIB2	8203

---

SCF(Skp2)-mediated degradation of p27/p21

SCF(Skp2)-mediated degradation of p27/p21

	1101
set	SCF(Skp2)-mediated degradation of p27/p21
setSize	59
pANOVA	3.91e-10
s.dist	-0.471
p.adjustANOVA	7.53e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
CKS1B	-6957
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
CKS1B	-6957
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
CCNE2	-5961
PSMD6	-5833
PSMB6	-5713
CCNA2	-5697
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
CCNE1	-3159
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
CCND1	-1484
PSMD8	-1257
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
CDK4	3
PSMF1	64
PSMD3	979
CDK2	1755
CDKN1B	1970
PSMB5	2441
SKP2	2843
PTK6	3337
CDKN1A	6568

---

Degradation of GLI2 by the proteasome

Degradation of GLI2 by the proteasome

	287
set	Degradation of GLI2 by the proteasome
setSize	57
pANOVA	7.77e-10
s.dist	-0.471
p.adjustANOVA	1.29e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMC1	-8029
CSNK1A1	-8028
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMC1	-8029
CSNK1A1	-8028
PSMA6	-7895
PSMD7	-7814
PSMB1	-7679
PSME1	-7437
PSMA3	-7386
PSMA2	-7318
PSMB4	-7316
PSMA5	-7183
PSMA4	-7145
PSMD10	-7126
PSMC5	-7104
PSMB7	-7084
PSMC3	-6991
PSMB9	-6862
PSMC6	-6662
PSMD13	-6654
PSMD14	-6383
SEM1	-6317
PSMA1	-6312
PSMD6	-5833
PSMB6	-5713
SKP1	-5412
PSMB3	-5270
UBC	-5168
PSMD4	-5136
PRKACB	-5130
PSMD1	-5092
PSMC2	-4975
PSMB8	-4559
PSMA7	-4277
RPS27A	-4208
PSMC4	-3765
PSME2	-3703
SUFU	-3047
GSK3B	-3036
PSME3	-2988
UBB	-2299
CUL1	-1621
PSMD11	-1599
PSMD8	-1257
RBX1	-1214
PSMD2	-793
PSMB2	-704
UBA52	-616
PSMD9	-564
PSMD5	-373
PSMB10	-283
PSMD12	-123
PSMF1	64
PSMD3	979
PSME4	1454
PSMB5	2441
PRKACA	6159
BTRC	6801
GLI2	6809

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          caTools_1.18.2          utf8_1.2.4             
## [16] promises_1.2.1          rmarkdown_2.25          tzdb_0.4.0             
## [19] xfun_0.41               cachem_1.0.8            zlibbioc_1.48.0        
## [22] jsonlite_1.8.8          highr_0.10              later_1.3.2            
## [25] DelayedArray_0.28.0     BiocParallel_1.36.0     parallel_4.3.2         
## [28] R6_2.5.1                bslib_0.6.1             stringi_1.8.3          
## [31] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [34] Rcpp_1.0.11             knitr_1.45              httpuv_1.6.13          
## [37] Matrix_1.6-4            timechange_0.2.0        tidyselect_1.2.0       
## [40] yaml_2.3.8              rstudioapi_0.15.0       abind_1.4-5            
## [43] codetools_0.2-19        lattice_0.22-5          plyr_1.8.9             
## [46] shiny_1.8.0             withr_2.5.2             evaluate_0.23          
## [49] ggstats_0.5.1           xml2_1.3.6              pillar_1.9.0           
## [52] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.13        
## [55] hms_1.1.3               munsell_0.5.0           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.6.2              tools_4.3.2            
## [61] data.table_1.14.10      webshot_0.5.5           locfit_1.5-9.8         
## [64] fastmatch_1.1-4         cowplot_1.1.2           grid_4.3.2             
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.11 cli_3.6.2              
## [70] fansi_1.0.6             viridisLite_0.4.2       S4Arrays_1.2.0         
## [73] svglite_2.1.3           gtable_0.3.4            sass_0.4.8             
## [76] digest_0.6.33           SparseArray_1.2.3       htmlwidgets_1.6.4      
## [79] htmltools_0.5.7         lifecycle_1.0.4         httr_1.4.7             
## [82] statmod_1.5.0           mime_0.12

END of report