Mitch Report

date generated: 2024-03-12

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	intact	torn
5_8S_rRNA	-3.451453	1.4758490
7SK	-1.426939	-0.5096905
A1BG	1.529759	2.8137638
A1BG.AS1	1.877187	1.2793604
A2M	-1.546889	-4.1729641
A2M.AS1	-1.368094	-0.8450553

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	16178
duplicated_genes_present	0
num_profile_genes_in_sets	8225
num_profile_genes_not_in_sets	7953
profile_pearson_correl	0.64572
profile_spearman_correl	0.68579

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways_2023-09-01.gmt

Gene set metrics

	Gene sets metrics
num_genesets	2612
num_genesets_excluded	1153
num_genesets_included	1459

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 435

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

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## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.intact	s.torn	p.intact	p.torn
Zinc transporters	10	1.51e-04	1.13e-03	0.993	0.685	0.719	1.77e-04	8.15e-05
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.73e-04	1.26e-03	0.987	-0.703	-0.692	1.17e-04	1.51e-04
Citric acid cycle (TCA cycle)	22	3.21e-09	7.33e-08	0.967	-0.764	-0.593	5.42e-10	1.47e-06
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	5.72e-05	5.18e-04	0.945	-0.804	-0.497	1.08e-05	6.54e-03
Glyoxylate metabolism and glycine degradation	23	1.86e-09	4.61e-08	0.929	-0.763	-0.529	2.29e-10	1.12e-05
Mucopolysaccharidoses	11	3.99e-04	2.49e-03	0.884	0.669	0.579	1.23e-04	8.84e-04
Dissolution of Fibrin Clot	10	1.16e-03	5.79e-03	0.851	0.663	0.533	2.85e-04	3.50e-03
Complex I biogenesis	51	7.55e-16	9.18e-14	0.847	-0.670	-0.519	1.19e-16	1.47e-10
FCGR activation	10	1.56e-03	7.27e-03	0.843	0.551	0.638	2.56e-03	4.80e-04
Trafficking and processing of endosomal TLR	12	4.73e-04	2.84e-03	0.829	0.525	0.642	1.65e-03	1.18e-04
CS/DS degradation	10	2.40e-03	1.02e-02	0.811	0.621	0.521	6.78e-04	4.30e-03
Expression and translocation of olfactory receptors	21	7.22e-11	2.57e-09	0.806	-0.245	-0.769	5.24e-02	1.07e-09
Respiratory electron transport	93	1.09e-25	5.29e-23	0.804	-0.639	-0.487	1.51e-26	4.64e-16
Diseases associated with N-glycosylation of proteins	20	5.02e-06	6.78e-05	0.802	0.633	0.494	9.63e-07	1.32e-04
Formation of ATP by chemiosmotic coupling	16	6.09e-05	5.36e-04	0.801	-0.630	-0.495	1.27e-05	6.14e-04
Keratan sulfate degradation	13	4.34e-04	2.67e-03	0.796	0.495	0.623	2.00e-03	9.94e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	7.84e-30	5.72e-27	0.788	-0.626	-0.479	1.21e-30	1.29e-18
The activation of arylsulfatases	10	3.81e-03	1.55e-02	0.781	0.594	0.507	1.15e-03	5.50e-03
Striated Muscle Contraction	34	1.52e-08	2.95e-07	0.769	-0.565	-0.522	1.16e-08	1.41e-07
Branched-chain amino acid catabolism	21	1.21e-07	2.07e-06	0.759	-0.684	-0.328	5.60e-08	9.18e-03
The citric acid (TCA) cycle and respiratory electron transport	160	1.53e-39	2.24e-36	0.751	-0.611	-0.436	1.03e-40	1.79e-21
Metal ion SLC transporters	18	1.39e-04	1.05e-03	0.743	0.507	0.543	1.97e-04	6.56e-05
Syndecan interactions	26	2.20e-06	3.28e-05	0.726	0.574	0.446	4.09e-07	8.38e-05
Glycogen synthesis	13	1.09e-03	5.50e-03	0.725	-0.592	-0.419	2.22e-04	8.96e-03
Olfactory Signaling Pathway	25	1.00e-10	3.47e-09	0.723	-0.208	-0.692	7.23e-02	2.04e-09
Chondroitin sulfate biosynthesis	15	1.23e-03	6.02e-03	0.692	0.539	0.435	3.04e-04	3.57e-03
Mitochondrial translation	94	1.94e-18	4.05e-16	0.690	-0.526	-0.446	1.24e-18	7.33e-14
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	3.61e-03	1.48e-02	0.689	0.558	0.403	8.09e-04	1.56e-02
Mitochondrial translation elongation	88	3.30e-17	6.02e-15	0.688	-0.523	-0.448	2.21e-17	3.85e-13
Pyruvate metabolism and Citric Acid (TCA) cycle	51	2.11e-12	1.02e-10	0.685	-0.589	-0.350	3.42e-13	1.50e-05
Phase 0 - rapid depolarisation	25	1.82e-05	2.05e-04	0.683	-0.426	-0.533	2.25e-04	3.89e-06
Mitochondrial translation initiation	88	9.09e-17	1.33e-14	0.680	-0.515	-0.443	6.36e-17	6.65e-13
Retrograde neurotrophin signalling	12	6.57e-03	2.51e-02	0.678	0.443	0.513	7.83e-03	2.07e-03
Mitochondrial translation termination	88	8.79e-17	1.33e-14	0.678	-0.517	-0.439	4.72e-17	1.14e-12
Cristae formation	29	5.29e-06	7.01e-05	0.672	-0.521	-0.424	1.21e-06	7.66e-05
Interleukin-10 signaling	29	1.06e-05	1.31e-04	0.667	0.469	0.474	1.22e-05	1.01e-05
Chondroitin sulfate/dermatan sulfate metabolism	41	7.85e-08	1.41e-06	0.664	0.499	0.439	3.24e-08	1.17e-06
G beta:gamma signalling through BTK	12	6.46e-03	2.48e-02	0.663	0.526	0.403	1.60e-03	1.57e-02
Mitochondrial calcium ion transport	22	4.68e-05	4.46e-04	0.659	-0.550	-0.364	8.07e-06	3.12e-03
ADP signalling through P2Y purinoceptor 12	14	1.28e-03	6.21e-03	0.654	0.560	0.338	2.87e-04	2.84e-02
Regulation of CDH11 gene transcription	10	9.52e-03	3.41e-02	0.653	0.345	0.555	5.92e-02	2.37e-03
Carnitine metabolism	14	8.80e-04	4.69e-03	0.651	-0.570	-0.315	2.24e-04	4.15e-02
Scavenging by Class A Receptors	16	9.33e-04	4.90e-03	0.638	0.538	0.343	1.94e-04	1.76e-02
Signal regulatory protein family interactions	11	1.79e-02	5.79e-02	0.637	0.474	0.426	6.51e-03	1.44e-02
RUNX3 regulates p14-ARF	10	2.68e-02	7.99e-02	0.622	0.390	0.485	3.29e-02	7.89e-03
Formation of annular gap junctions	11	2.25e-02	6.92e-02	0.622	0.428	0.451	1.39e-02	9.63e-03
RHO GTPases activate IQGAPs	22	6.66e-05	5.75e-04	0.621	0.535	0.315	1.38e-05	1.04e-02
Gap junction degradation	12	1.75e-02	5.69e-02	0.615	0.442	0.428	8.05e-03	1.02e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	1.32e-02	4.50e-02	0.611	0.418	0.445	9.02e-03	5.50e-03
FCGR3A-mediated phagocytosis	57	4.52e-09	9.43e-08	0.599	0.470	0.372	8.50e-10	1.22e-06

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.intact	s.torn	p.intact	p.torn
Zinc transporters	10	1.51e-04	1.13e-03	0.99300	6.85e-01	0.719000	1.77e-04	8.15e-05
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10	1.73e-04	1.26e-03	0.98700	-7.03e-01	-0.692000	1.17e-04	1.51e-04
Citric acid cycle (TCA cycle)	22	3.21e-09	7.33e-08	0.96700	-7.64e-01	-0.593000	5.42e-10	1.47e-06
mitochondrial fatty acid beta-oxidation of saturated fatty acids	10	5.72e-05	5.18e-04	0.94500	-8.04e-01	-0.497000	1.08e-05	6.54e-03
Glyoxylate metabolism and glycine degradation	23	1.86e-09	4.61e-08	0.92900	-7.63e-01	-0.529000	2.29e-10	1.12e-05
Mucopolysaccharidoses	11	3.99e-04	2.49e-03	0.88400	6.69e-01	0.579000	1.23e-04	8.84e-04
Dissolution of Fibrin Clot	10	1.16e-03	5.79e-03	0.85100	6.63e-01	0.533000	2.85e-04	3.50e-03
Complex I biogenesis	51	7.55e-16	9.18e-14	0.84700	-6.70e-01	-0.519000	1.19e-16	1.47e-10
FCGR activation	10	1.56e-03	7.27e-03	0.84300	5.51e-01	0.638000	2.56e-03	4.80e-04
Trafficking and processing of endosomal TLR	12	4.73e-04	2.84e-03	0.82900	5.25e-01	0.642000	1.65e-03	1.18e-04
CS/DS degradation	10	2.40e-03	1.02e-02	0.81100	6.21e-01	0.521000	6.78e-04	4.30e-03
Expression and translocation of olfactory receptors	21	7.22e-11	2.57e-09	0.80600	-2.45e-01	-0.769000	5.24e-02	1.07e-09
Respiratory electron transport	93	1.09e-25	5.29e-23	0.80400	-6.39e-01	-0.487000	1.51e-26	4.64e-16
Diseases associated with N-glycosylation of proteins	20	5.02e-06	6.78e-05	0.80200	6.33e-01	0.494000	9.63e-07	1.32e-04
Formation of ATP by chemiosmotic coupling	16	6.09e-05	5.36e-04	0.80100	-6.30e-01	-0.495000	1.27e-05	6.14e-04
Keratan sulfate degradation	13	4.34e-04	2.67e-03	0.79600	4.95e-01	0.623000	2.00e-03	9.94e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	7.84e-30	5.72e-27	0.78800	-6.26e-01	-0.479000	1.21e-30	1.29e-18
The activation of arylsulfatases	10	3.81e-03	1.55e-02	0.78100	5.94e-01	0.507000	1.15e-03	5.50e-03
Striated Muscle Contraction	34	1.52e-08	2.95e-07	0.76900	-5.65e-01	-0.522000	1.16e-08	1.41e-07
Branched-chain amino acid catabolism	21	1.21e-07	2.07e-06	0.75900	-6.84e-01	-0.328000	5.60e-08	9.18e-03
The citric acid (TCA) cycle and respiratory electron transport	160	1.53e-39	2.24e-36	0.75100	-6.11e-01	-0.436000	1.03e-40	1.79e-21
Metal ion SLC transporters	18	1.39e-04	1.05e-03	0.74300	5.07e-01	0.543000	1.97e-04	6.56e-05
Syndecan interactions	26	2.20e-06	3.28e-05	0.72600	5.74e-01	0.446000	4.09e-07	8.38e-05
Glycogen synthesis	13	1.09e-03	5.50e-03	0.72500	-5.92e-01	-0.419000	2.22e-04	8.96e-03
Olfactory Signaling Pathway	25	1.00e-10	3.47e-09	0.72300	-2.08e-01	-0.692000	7.23e-02	2.04e-09
Chondroitin sulfate biosynthesis	15	1.23e-03	6.02e-03	0.69200	5.39e-01	0.435000	3.04e-04	3.57e-03
Mitochondrial translation	94	1.94e-18	4.05e-16	0.69000	-5.26e-01	-0.446000	1.24e-18	7.33e-14
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	12	3.61e-03	1.48e-02	0.68900	5.58e-01	0.403000	8.09e-04	1.56e-02
Mitochondrial translation elongation	88	3.30e-17	6.02e-15	0.68800	-5.23e-01	-0.448000	2.21e-17	3.85e-13
Pyruvate metabolism and Citric Acid (TCA) cycle	51	2.11e-12	1.02e-10	0.68500	-5.89e-01	-0.350000	3.42e-13	1.50e-05
Phase 0 - rapid depolarisation	25	1.82e-05	2.05e-04	0.68300	-4.26e-01	-0.533000	2.25e-04	3.89e-06
Mitochondrial translation initiation	88	9.09e-17	1.33e-14	0.68000	-5.15e-01	-0.443000	6.36e-17	6.65e-13
Retrograde neurotrophin signalling	12	6.57e-03	2.51e-02	0.67800	4.43e-01	0.513000	7.83e-03	2.07e-03
Mitochondrial translation termination	88	8.79e-17	1.33e-14	0.67800	-5.17e-01	-0.439000	4.72e-17	1.14e-12
Cristae formation	29	5.29e-06	7.01e-05	0.67200	-5.21e-01	-0.424000	1.21e-06	7.66e-05
Interleukin-10 signaling	29	1.06e-05	1.31e-04	0.66700	4.69e-01	0.474000	1.22e-05	1.01e-05
Chondroitin sulfate/dermatan sulfate metabolism	41	7.85e-08	1.41e-06	0.66400	4.99e-01	0.439000	3.24e-08	1.17e-06
G beta:gamma signalling through BTK	12	6.46e-03	2.48e-02	0.66300	5.26e-01	0.403000	1.60e-03	1.57e-02
Mitochondrial calcium ion transport	22	4.68e-05	4.46e-04	0.65900	-5.50e-01	-0.364000	8.07e-06	3.12e-03
ADP signalling through P2Y purinoceptor 12	14	1.28e-03	6.21e-03	0.65400	5.60e-01	0.338000	2.87e-04	2.84e-02
Regulation of CDH11 gene transcription	10	9.52e-03	3.41e-02	0.65300	3.45e-01	0.555000	5.92e-02	2.37e-03
Carnitine metabolism	14	8.80e-04	4.69e-03	0.65100	-5.70e-01	-0.315000	2.24e-04	4.15e-02
Scavenging by Class A Receptors	16	9.33e-04	4.90e-03	0.63800	5.38e-01	0.343000	1.94e-04	1.76e-02
Signal regulatory protein family interactions	11	1.79e-02	5.79e-02	0.63700	4.74e-01	0.426000	6.51e-03	1.44e-02
RUNX3 regulates p14-ARF	10	2.68e-02	7.99e-02	0.62200	3.90e-01	0.485000	3.29e-02	7.89e-03
Formation of annular gap junctions	11	2.25e-02	6.92e-02	0.62200	4.28e-01	0.451000	1.39e-02	9.63e-03
RHO GTPases activate IQGAPs	22	6.66e-05	5.75e-04	0.62100	5.35e-01	0.315000	1.38e-05	1.04e-02
Gap junction degradation	12	1.75e-02	5.69e-02	0.61500	4.42e-01	0.428000	8.05e-03	1.02e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13	1.32e-02	4.50e-02	0.61100	4.18e-01	0.445000	9.02e-03	5.50e-03
FCGR3A-mediated phagocytosis	57	4.52e-09	9.43e-08	0.59900	4.70e-01	0.372000	8.50e-10	1.22e-06
Leishmania phagocytosis	57	4.52e-09	9.43e-08	0.59900	4.70e-01	0.372000	8.50e-10	1.22e-06
Parasite infection	57	4.52e-09	9.43e-08	0.59900	4.70e-01	0.372000	8.50e-10	1.22e-06
WNT5A-dependent internalization of FZD4	14	7.37e-03	2.75e-02	0.58900	3.36e-01	0.484000	2.94e-02	1.73e-03
Processing of SMDT1	15	1.71e-03	7.75e-03	0.58700	-5.20e-01	-0.273000	4.90e-04	6.68e-02
SARS-CoV-1 modulates host translation machinery	36	1.74e-06	2.64e-05	0.58000	3.04e-01	0.494000	1.62e-03	2.95e-07
Regulation of pyruvate dehydrogenase (PDH) complex	15	4.70e-04	2.84e-03	0.57700	-5.39e-01	-0.207000	3.00e-04	1.66e-01
Diseases associated with glycosaminoglycan metabolism	37	2.02e-05	2.27e-04	0.57300	4.06e-01	0.405000	1.91e-05	2.03e-05
Cardiogenesis	19	3.94e-03	1.59e-02	0.57100	-3.91e-01	-0.416000	3.15e-03	1.68e-03
G beta:gamma signalling through PI3Kgamma	19	4.10e-03	1.65e-02	0.57000	4.10e-01	0.396000	1.97e-03	2.80e-03
Nitric oxide stimulates guanylate cyclase	17	1.31e-04	9.99e-04	0.56800	-1.86e-01	-0.537000	1.84e-01	1.26e-04
Mitochondrial protein import	63	1.78e-09	4.47e-08	0.56100	-4.62e-01	-0.318000	2.18e-10	1.25e-05
The role of Nef in HIV-1 replication and disease pathogenesis	23	1.46e-03	6.85e-03	0.56100	4.20e-01	0.371000	4.91e-04	2.04e-03
HSF1-dependent transactivation	33	2.74e-05	2.93e-04	0.56000	-4.61e-01	-0.317000	4.57e-06	1.62e-03
Prostacyclin signalling through prostacyclin receptor	13	2.46e-02	7.40e-02	0.55900	4.25e-01	0.363000	7.98e-03	2.35e-02
RHO GTPases Activate WASPs and WAVEs	36	1.00e-05	1.25e-04	0.55700	4.62e-01	0.311000	1.61e-06	1.26e-03
Regulation of actin dynamics for phagocytic cup formation	59	1.36e-07	2.31e-06	0.54500	4.09e-01	0.360000	5.52e-08	1.76e-06
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	11	2.93e-02	8.54e-02	0.54300	4.61e-01	0.287000	8.10e-03	9.89e-02
Lysine catabolism	11	3.64e-02	1.00e-01	0.54300	-4.48e-01	-0.307000	1.00e-02	7.79e-02
RHO GTPases Activate NADPH Oxidases	21	2.15e-03	9.42e-03	0.54300	3.16e-01	0.441000	1.21e-02	4.62e-04
Elastic fibre formation	41	1.22e-05	1.49e-04	0.54300	4.24e-01	0.339000	2.60e-06	1.74e-04
Collagen biosynthesis and modifying enzymes	58	1.88e-07	3.12e-06	0.54300	4.10e-01	0.356000	6.67e-08	2.83e-06
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	17	1.22e-02	4.19e-02	0.54000	3.81e-01	0.383000	6.55e-03	6.29e-03
SRP-dependent cotranslational protein targeting to membrane	111	1.45e-14	1.41e-12	0.53700	3.10e-01	0.438000	1.64e-08	1.47e-15
Signaling by Leptin	11	1.73e-03	7.82e-03	0.53300	-5.21e-01	-0.112000	2.76e-03	5.20e-01
Transport of connexons to the plasma membrane	12	3.32e-02	9.39e-02	0.53300	4.35e-01	0.308000	9.10e-03	6.44e-02
Peptide chain elongation	88	8.55e-14	6.24e-12	0.52900	2.48e-01	0.468000	5.96e-05	3.33e-14
Caspase activation via Death Receptors in the presence of ligand	15	1.11e-02	3.87e-02	0.52800	4.46e-01	0.283000	2.77e-03	5.77e-02
Antimicrobial peptides	20	6.68e-03	2.54e-02	0.52600	3.46e-01	0.396000	7.41e-03	2.18e-03
DAP12 interactions	32	3.18e-04	2.10e-03	0.52500	4.00e-01	0.340000	9.10e-05	8.63e-04
Glycogen storage diseases	14	1.60e-02	5.26e-02	0.52500	-4.43e-01	-0.282000	4.12e-03	6.81e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	2.17e-02	6.74e-02	0.52400	4.27e-01	0.304000	5.66e-03	4.93e-02
Post-translational protein phosphorylation	76	2.45e-09	5.77e-08	0.52300	4.15e-01	0.318000	3.85e-10	1.68e-06
G beta:gamma signalling through PLC beta	14	2.10e-02	6.61e-02	0.52200	4.29e-01	0.297000	5.45e-03	5.40e-02
Presynaptic function of Kainate receptors	14	2.10e-02	6.61e-02	0.52200	4.29e-01	0.297000	5.45e-03	5.40e-02
GPVI-mediated activation cascade	31	5.29e-04	3.11e-03	0.52200	3.55e-01	0.383000	6.26e-04	2.28e-04
Collagen formation	78	2.99e-09	6.92e-08	0.52200	4.04e-01	0.330000	7.05e-10	4.64e-07
Thrombin signalling through proteinase activated receptors (PARs)	23	6.70e-04	3.75e-03	0.52000	4.54e-01	0.255000	1.64e-04	3.45e-02
Prolactin receptor signaling	10	3.20e-02	9.13e-02	0.51900	-4.64e-01	-0.232000	1.10e-02	2.03e-01
Beta-oxidation of very long chain fatty acids	10	1.68e-03	7.66e-03	0.51900	-5.15e-01	-0.061800	4.78e-03	7.35e-01
Viral mRNA Translation	88	5.87e-13	3.29e-11	0.51800	2.49e-01	0.455000	5.51e-05	1.67e-13
LDL clearance	17	1.72e-02	5.59e-02	0.51500	3.85e-01	0.342000	6.01e-03	1.47e-02
VEGFR2 mediated cell proliferation	19	5.20e-03	2.04e-02	0.51200	4.29e-01	0.279000	1.20e-03	3.53e-02
IRAK4 deficiency (TLR2/4)	15	2.35e-02	7.17e-02	0.51100	3.11e-01	0.406000	3.70e-02	6.50e-03
Degradation of cysteine and homocysteine	14	1.45e-03	6.81e-03	0.51100	-4.91e-01	-0.143000	1.47e-03	3.53e-01
COPI-dependent Golgi-to-ER retrograde traffic	83	9.58e-10	2.54e-08	0.50500	4.09e-01	0.297000	1.24e-10	2.86e-06
Activation of kainate receptors upon glutamate binding	21	2.71e-03	1.15e-02	0.50500	4.31e-01	0.263000	6.26e-04	3.70e-02
Intraflagellar transport	48	7.44e-06	9.61e-05	0.50300	4.04e-01	0.298000	1.25e-06	3.47e-04
Mitochondrial Fatty Acid Beta-Oxidation	34	1.28e-06	1.99e-05	0.50200	-4.72e-01	-0.172000	1.90e-06	8.34e-02
The NLRP3 inflammasome	16	1.56e-02	5.18e-02	0.50100	2.79e-01	0.416000	5.33e-02	3.93e-03
Fcgamma receptor (FCGR) dependent phagocytosis	82	8.76e-09	1.75e-07	0.50000	3.77e-01	0.329000	3.63e-09	2.63e-07
cGMP effects	14	3.61e-04	2.34e-03	0.49800	-7.12e-02	-0.493000	6.44e-01	1.40e-03
Leading Strand Synthesis	14	2.22e-03	9.61e-03	0.49700	4.76e-01	0.142000	2.04e-03	3.58e-01
Polymerase switching	14	2.22e-03	9.61e-03	0.49700	4.76e-01	0.142000	2.04e-03	3.58e-01
Mitochondrial iron-sulfur cluster biogenesis	13	7.69e-03	2.85e-02	0.49500	-4.62e-01	-0.178000	3.92e-03	2.66e-01
Recycling pathway of L1	38	5.01e-05	4.63e-04	0.49500	4.16e-01	0.268000	8.90e-06	4.32e-03
Selenocysteine synthesis	92	2.98e-13	1.81e-11	0.49400	2.18e-01	0.443000	2.99e-04	2.12e-13
Eukaryotic Translation Elongation	93	2.05e-13	1.36e-11	0.49300	2.17e-01	0.443000	2.92e-04	1.54e-13
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	2.57e-13	1.63e-11	0.49300	2.36e-01	0.433000	4.58e-05	7.62e-14
Class I peroxisomal membrane protein import	20	1.35e-02	4.56e-02	0.49200	-3.53e-01	-0.342000	6.21e-03	8.16e-03
Regulation of FOXO transcriptional activity by acetylation	10	1.66e-03	7.64e-03	0.49100	-4.90e-01	-0.021800	7.28e-03	9.05e-01
Mitochondrial biogenesis	87	4.28e-09	9.33e-08	0.49000	-3.79e-01	-0.310000	1.02e-09	5.72e-07
MyD88 deficiency (TLR2/4)	14	3.60e-02	9.93e-02	0.49000	2.86e-01	0.398000	6.42e-02	1.00e-02
Eukaryotic Translation Termination	92	1.94e-12	9.74e-11	0.48900	2.28e-01	0.433000	1.56e-04	7.17e-13
FOXO-mediated transcription of cell death genes	15	2.05e-04	1.46e-03	0.48800	-4.85e-01	-0.057400	1.16e-03	7.01e-01
CD28 dependent Vav1 pathway	10	1.15e-01	2.46e-01	0.48700	3.68e-01	0.319000	4.37e-02	8.06e-02
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	6.48e-13	3.50e-11	0.48400	2.16e-01	0.433000	3.04e-04	4.03e-13
Energy dependent regulation of mTOR by LKB1-AMPK	29	2.28e-03	9.85e-03	0.48300	-3.59e-01	-0.323000	8.25e-04	2.57e-03
Metabolism of cofactors	18	2.37e-02	7.18e-02	0.48200	-3.25e-01	-0.356000	1.71e-02	8.99e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	85	4.64e-09	9.54e-08	0.48200	3.88e-01	0.285000	6.40e-10	5.46e-06
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	80	2.82e-08	5.27e-07	0.48100	2.97e-01	0.378000	4.45e-06	5.16e-09
Other interleukin signaling	19	1.65e-02	5.40e-02	0.47800	2.94e-01	0.377000	2.64e-02	4.49e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	33	3.06e-04	2.06e-03	0.47600	4.03e-01	0.252000	6.09e-05	1.22e-02
Assembly of the ORC complex at the origin of replication	14	4.03e-02	1.09e-01	0.47500	-2.69e-01	-0.391000	8.10e-02	1.13e-02
Pexophagy	11	4.13e-02	1.11e-01	0.47400	-4.25e-01	-0.210000	1.46e-02	2.28e-01
Glycosaminoglycan metabolism	103	7.08e-10	2.03e-08	0.47300	3.63e-01	0.303000	2.04e-10	1.09e-07
Collagen degradation	50	2.41e-05	2.69e-04	0.47200	3.75e-01	0.288000	4.62e-06	4.28e-04
Resolution of D-loop Structures through Holliday Junction Intermediates	32	2.74e-05	2.93e-04	0.47200	4.37e-01	0.177000	1.88e-05	8.25e-02
Peroxisomal protein import	56	2.44e-09	5.77e-08	0.46900	-4.43e-01	-0.156000	1.02e-08	4.30e-02
Resolution of D-Loop Structures	33	3.26e-05	3.30e-04	0.46900	4.31e-01	0.185000	1.82e-05	6.64e-02
A tetrasaccharide linker sequence is required for GAG synthesis	20	1.92e-02	6.16e-02	0.46700	3.51e-01	0.308000	6.51e-03	1.72e-02
ERBB2 Activates PTK6 Signaling	11	5.42e-02	1.40e-01	0.46700	-2.20e-01	-0.412000	2.07e-01	1.81e-02
Heme biosynthesis	12	5.61e-02	1.42e-01	0.46600	-3.98e-01	-0.243000	1.70e-02	1.45e-01
Glycogen metabolism	24	3.48e-03	1.44e-02	0.46600	-3.95e-01	-0.246000	8.01e-04	3.67e-02
Molecules associated with elastic fibres	34	6.60e-04	3.70e-03	0.46500	3.79e-01	0.269000	1.31e-04	6.55e-03
Pyruvate metabolism	27	1.58e-04	1.17e-03	0.46500	-4.32e-01	-0.171000	1.02e-04	1.25e-01
Impaired BRCA2 binding to PALB2	23	6.95e-05	5.83e-04	0.46400	4.51e-01	0.110000	1.83e-04	3.60e-01
Heparan sulfate/heparin (HS-GAG) metabolism	41	3.17e-04	2.10e-03	0.46300	3.55e-01	0.297000	8.55e-05	9.86e-04
ADP signalling through P2Y purinoceptor 1	19	2.40e-02	7.28e-02	0.46000	3.56e-01	0.292000	7.25e-03	2.77e-02
PI3K events in ERBB2 signaling	14	6.09e-02	1.52e-01	0.45900	-2.81e-01	-0.362000	6.86e-02	1.89e-02
Ion homeostasis	47	2.63e-05	2.87e-04	0.45700	-2.45e-01	-0.386000	3.70e-03	4.63e-06
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	24	4.31e-05	4.20e-04	0.45600	4.46e-01	0.098600	1.57e-04	4.03e-01
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	24	4.31e-05	4.20e-04	0.45600	4.46e-01	0.098600	1.57e-04	4.03e-01
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	24	4.31e-05	4.20e-04	0.45600	4.46e-01	0.098600	1.57e-04	4.03e-01
Defective homologous recombination repair (HRR) due to PALB2 loss of function	24	4.31e-05	4.20e-04	0.45600	4.46e-01	0.098600	1.57e-04	4.03e-01
IRE1alpha activates chaperones	50	5.88e-05	5.26e-04	0.45500	2.83e-01	0.357000	5.46e-04	1.25e-05
Triglyceride catabolism	16	5.17e-02	1.34e-01	0.45400	-3.04e-01	-0.337000	3.52e-02	1.96e-02
Advanced glycosylation endproduct receptor signaling	11	1.56e-02	5.18e-02	0.45400	4.37e-01	0.120000	1.20e-02	4.89e-01
PI-3K cascade:FGFR4	12	1.05e-01	2.34e-01	0.45200	-2.92e-01	-0.346000	8.00e-02	3.82e-02
XBP1(S) activates chaperone genes	48	1.04e-04	8.07e-04	0.45200	2.82e-01	0.353000	7.16e-04	2.32e-05
G-protein beta:gamma signalling	26	8.92e-03	3.22e-02	0.45200	3.23e-01	0.317000	4.42e-03	5.22e-03
G beta:gamma signalling through CDC42	14	5.81e-02	1.46e-01	0.45100	3.68e-01	0.261000	1.71e-02	9.12e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	8.06e-05	6.61e-04	0.44800	4.31e-01	0.123000	1.42e-04	2.76e-01
Incretin synthesis, secretion, and inactivation	13	3.46e-02	9.69e-02	0.44800	4.02e-01	0.198000	1.21e-02	2.15e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	13	3.46e-02	9.69e-02	0.44800	4.02e-01	0.198000	1.21e-02	2.15e-01
Diseases associated with glycosylation precursor biosynthesis	15	5.80e-02	1.46e-01	0.44800	2.75e-01	0.353000	6.50e-02	1.79e-02
Diseases associated with the TLR signaling cascade	27	7.77e-03	2.86e-02	0.44800	3.00e-01	0.332000	6.96e-03	2.83e-03
Diseases of Immune System	27	7.77e-03	2.86e-02	0.44800	3.00e-01	0.332000	6.96e-03	2.83e-03
Platelet Adhesion to exposed collagen	11	1.20e-01	2.53e-01	0.44500	3.58e-01	0.264000	3.99e-02	1.29e-01
ERBB2 Regulates Cell Motility	13	1.79e-02	5.79e-02	0.44400	-1.54e-01	-0.417000	3.36e-01	9.27e-03
Condensation of Prometaphase Chromosomes	11	1.53e-02	5.12e-02	0.44400	4.31e-01	0.106000	1.33e-02	5.41e-01
Calnexin/calreticulin cycle	26	9.98e-03	3.56e-02	0.44400	2.97e-01	0.330000	8.85e-03	3.57e-03
Signal amplification	25	7.23e-03	2.73e-02	0.44300	3.63e-01	0.254000	1.69e-03	2.82e-02
Muscle contraction	160	1.17e-13	8.11e-12	0.44100	-2.66e-01	-0.352000	6.93e-09	1.55e-14
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	23	7.36e-04	4.04e-03	0.44000	-4.16e-01	-0.146000	5.62e-04	2.27e-01
CRMPs in Sema3A signaling	14	9.04e-02	2.07e-01	0.43900	3.04e-01	0.317000	4.89e-02	4.02e-02
Peroxisomal lipid metabolism	26	9.39e-05	7.44e-04	0.43800	-4.23e-01	-0.114000	1.86e-04	3.15e-01
Mitochondrial tRNA aminoacylation	21	1.97e-03	8.82e-03	0.43800	-4.09e-01	-0.154000	1.16e-03	2.21e-01
Maturation of spike protein 9694548	37	1.56e-03	7.27e-03	0.43600	3.35e-01	0.279000	4.26e-04	3.33e-03
ABC transporters in lipid homeostasis	13	1.12e-01	2.42e-01	0.43500	-3.12e-01	-0.303000	5.13e-02	5.88e-02
ATF6 (ATF6-alpha) activates chaperones	12	1.33e-01	2.74e-01	0.43300	2.92e-01	0.320000	7.99e-02	5.50e-02
Assembly of collagen fibrils and other multimeric structures	53	6.21e-05	5.43e-04	0.43300	3.49e-01	0.257000	1.13e-05	1.22e-03
Synthesis of PIPs at the Golgi membrane	15	8.18e-02	1.91e-01	0.43300	3.12e-01	0.300000	3.63e-02	4.43e-02
EPH-ephrin mediated repulsion of cells	45	1.84e-04	1.32e-03	0.43200	3.57e-01	0.243000	3.37e-05	4.79e-03
DARPP-32 events	23	1.42e-02	4.76e-02	0.43200	-3.51e-01	-0.252000	3.56e-03	3.66e-02
Interaction between L1 and Ankyrins	24	1.19e-02	4.09e-02	0.43200	-2.52e-01	-0.351000	3.27e-02	2.93e-03
Dectin-2 family	13	1.10e-01	2.39e-01	0.43100	2.79e-01	0.328000	8.13e-02	4.03e-02
PKA activation	16	5.64e-02	1.43e-01	0.43100	-2.58e-01	-0.345000	7.45e-02	1.69e-02
Defects in cobalamin (B12) metabolism	12	1.38e-01	2.80e-01	0.43000	-3.13e-01	-0.294000	6.04e-02	7.76e-02
RAF activation	34	3.29e-03	1.37e-02	0.42700	-2.72e-01	-0.329000	6.06e-03	9.02e-04
Unwinding of DNA	11	3.69e-02	1.01e-01	0.42700	4.04e-01	0.137000	2.03e-02	4.30e-01
Folding of actin by CCT/TriC	10	3.51e-02	9.79e-02	0.42700	-1.13e-01	-0.411000	5.37e-01	2.43e-02
Regulation of ornithine decarboxylase (ODC)	48	1.66e-05	1.95e-04	0.42600	-1.92e-01	-0.380000	2.12e-02	5.23e-06
SUMOylation of immune response proteins	11	1.69e-01	3.26e-01	0.42600	2.94e-01	0.308000	9.17e-02	7.65e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	27	1.31e-02	4.45e-02	0.42500	2.94e-01	0.307000	8.22e-03	5.79e-03
Formation of apoptosome	11	1.43e-01	2.87e-01	0.42500	-2.50e-01	-0.343000	1.51e-01	4.88e-02
Regulation of the apoptosome activity	11	1.43e-01	2.87e-01	0.42500	-2.50e-01	-0.343000	1.51e-01	4.88e-02
Gastrin-CREB signalling pathway via PKC and MAPK	16	1.98e-02	6.32e-02	0.42400	3.86e-01	0.177000	7.54e-03	2.21e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	11	4.69e-03	1.86e-02	0.42400	4.24e-01	0.012600	1.50e-02	9.42e-01
Transport of bile salts and organic acids, metal ions and amine compounds	45	5.17e-04	3.08e-03	0.42400	2.64e-01	0.331000	2.21e-03	1.20e-04
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	72	2.01e-06	3.02e-05	0.42300	3.49e-01	0.238000	3.02e-07	4.76e-04
Protein localization	154	1.82e-15	2.05e-13	0.42200	-3.75e-01	-0.194000	9.99e-16	3.29e-05
TNFs bind their physiological receptors	18	5.50e-02	1.40e-01	0.42100	3.19e-01	0.275000	1.93e-02	4.34e-02
Inflammasomes	20	2.13e-02	6.66e-02	0.42100	2.22e-01	0.357000	8.51e-02	5.71e-03
PKA activation in glucagon signalling	15	9.56e-02	2.17e-01	0.42000	-2.97e-01	-0.297000	4.67e-02	4.67e-02
Azathioprine ADME	18	5.31e-02	1.37e-01	0.41900	3.25e-01	0.264000	1.69e-02	5.27e-02
Thromboxane signalling through TP receptor	18	3.21e-02	9.13e-02	0.41700	3.55e-01	0.217000	9.06e-03	1.10e-01
rRNA processing in the mitochondrion	10	1.71e-01	3.29e-01	0.41700	-2.36e-01	-0.343000	1.96e-01	6.02e-02
Kinesins	44	4.86e-06	6.63e-05	0.41600	3.92e-01	0.139000	6.71e-06	1.10e-01
Formation of a pool of free 40S subunits	100	2.72e-11	1.07e-09	0.41500	1.64e-01	0.381000	4.55e-03	4.60e-11
HS-GAG degradation	21	2.82e-02	8.31e-02	0.41400	3.36e-01	0.242000	7.62e-03	5.51e-02
Binding and Uptake of Ligands by Scavenger Receptors	32	1.36e-03	6.53e-03	0.41200	3.64e-01	0.195000	3.73e-04	5.68e-02
G-protein activation	17	4.04e-02	1.09e-01	0.41200	3.53e-01	0.213000	1.18e-02	1.28e-01
ATF6 (ATF6-alpha) activates chaperone genes	10	1.93e-01	3.58e-01	0.41200	2.47e-01	0.330000	1.77e-01	7.07e-02
Selenoamino acid metabolism	114	2.68e-12	1.22e-10	0.41200	1.68e-01	0.376000	1.97e-03	4.08e-12
APC truncation mutants have impaired AXIN binding	14	1.08e-01	2.37e-01	0.41000	-3.23e-01	-0.252000	3.64e-02	1.03e-01
AXIN missense mutants destabilize the destruction complex	14	1.08e-01	2.37e-01	0.41000	-3.23e-01	-0.252000	3.64e-02	1.03e-01
Signaling by AMER1 mutants	14	1.08e-01	2.37e-01	0.41000	-3.23e-01	-0.252000	3.64e-02	1.03e-01
Signaling by APC mutants	14	1.08e-01	2.37e-01	0.41000	-3.23e-01	-0.252000	3.64e-02	1.03e-01
Signaling by AXIN mutants	14	1.08e-01	2.37e-01	0.41000	-3.23e-01	-0.252000	3.64e-02	1.03e-01
Truncations of AMER1 destabilize the destruction complex	14	1.08e-01	2.37e-01	0.41000	-3.23e-01	-0.252000	3.64e-02	1.03e-01
Sulfur amino acid metabolism	25	1.02e-03	5.30e-03	0.40900	-3.87e-01	-0.132000	8.04e-04	2.55e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	5.84e-05	5.26e-04	0.40900	-2.13e-01	-0.349000	7.26e-03	1.12e-05
PINK1-PRKN Mediated Mitophagy	21	1.54e-02	5.12e-02	0.40800	-3.58e-01	-0.196000	4.53e-03	1.20e-01
Pentose phosphate pathway	13	1.30e-01	2.69e-01	0.40700	3.21e-01	0.251000	4.52e-02	1.17e-01
Regulation of Apoptosis	51	9.55e-05	7.49e-04	0.40600	-2.12e-01	-0.346000	8.98e-03	1.87e-05
Regulated proteolysis of p75NTR	11	1.36e-01	2.79e-01	0.40500	3.46e-01	0.212000	4.70e-02	2.24e-01
Diseases of glycosylation	124	1.51e-08	2.95e-07	0.40400	2.98e-01	0.272000	1.03e-08	1.65e-07
Cell recruitment (pro-inflammatory response)	24	3.17e-02	9.09e-02	0.40200	2.86e-01	0.283000	1.53e-02	1.64e-02
Purinergic signaling in leishmaniasis infection	24	3.17e-02	9.09e-02	0.40200	2.86e-01	0.283000	1.53e-02	1.64e-02
EPHB-mediated forward signaling	40	3.09e-04	2.06e-03	0.40200	3.58e-01	0.184000	9.13e-05	4.45e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	1.16e-04	8.96e-04	0.39700	-1.90e-01	-0.349000	2.29e-02	2.93e-05
Crosslinking of collagen fibrils	17	8.87e-02	2.04e-01	0.39400	3.01e-01	0.254000	3.15e-02	6.95e-02
DNA strand elongation	31	3.09e-04	2.06e-03	0.39400	3.74e-01	0.122000	3.11e-04	2.38e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	6.48e-02	1.60e-01	0.39300	-3.71e-01	-0.131000	3.34e-02	4.52e-01
Degradation of GLI2 by the proteasome	57	4.78e-05	4.50e-04	0.39300	-1.99e-01	-0.339000	9.38e-03	9.84e-06
Degradation of DVL	55	1.76e-04	1.27e-03	0.39200	-2.20e-01	-0.324000	4.87e-03	3.20e-05
MTOR signalling	41	2.94e-03	1.23e-02	0.39100	-3.04e-01	-0.247000	7.71e-04	6.19e-03
Mitotic Telophase/Cytokinesis	13	2.50e-02	7.50e-02	0.38900	3.76e-01	0.098300	1.89e-02	5.40e-01
Smooth Muscle Contraction	36	1.18e-04	9.09e-04	0.38800	-1.22e-01	-0.368000	2.04e-01	1.31e-04
Caspase activation via extrinsic apoptotic signalling pathway	23	4.14e-02	1.11e-01	0.38700	2.99e-01	0.246000	1.32e-02	4.08e-02
Interleukin-12 signaling	40	2.12e-03	9.33e-03	0.38600	3.21e-01	0.216000	4.50e-04	1.84e-02
Vpu mediated degradation of CD4	50	2.22e-04	1.55e-03	0.38600	-1.97e-01	-0.333000	1.62e-02	4.74e-05
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	52	1.46e-04	1.11e-03	0.38600	-1.94e-01	-0.333000	1.56e-02	3.19e-05
HDMs demethylate histones	21	1.70e-05	1.96e-04	0.38400	-7.25e-02	0.377000	5.65e-01	2.79e-03
Constitutive Signaling by NOTCH1 HD Domain Mutants	15	3.60e-02	9.93e-02	0.38400	-1.41e-01	-0.357000	3.45e-01	1.67e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer	15	3.60e-02	9.93e-02	0.38400	-1.41e-01	-0.357000	3.45e-01	1.67e-02
Lysosome Vesicle Biogenesis	31	1.35e-02	4.56e-02	0.38300	3.02e-01	0.237000	3.65e-03	2.26e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	5.67e-05	5.17e-04	0.38300	-2.11e-01	-0.320000	3.49e-03	9.89e-06
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	3.47e-11	1.30e-09	0.38200	1.47e-01	0.353000	6.93e-03	7.77e-11
Nonsense-Mediated Decay (NMD)	114	3.47e-11	1.30e-09	0.38200	1.47e-01	0.353000	6.93e-03	7.77e-11
SARS-CoV-2 modulates host translation machinery	49	7.13e-04	3.95e-03	0.38200	2.17e-01	0.314000	8.72e-03	1.41e-04
Tryptophan catabolism	10	2.20e-01	3.83e-01	0.38000	3.17e-01	0.208000	8.22e-02	2.54e-01
Hyaluronan metabolism	14	1.26e-01	2.62e-01	0.38000	3.14e-01	0.213000	4.17e-02	1.69e-01
CASP8 activity is inhibited	10	1.36e-01	2.79e-01	0.37900	3.46e-01	0.155000	5.80e-02	3.97e-01
Dimerization of procaspase-8	10	1.36e-01	2.79e-01	0.37900	3.46e-01	0.155000	5.80e-02	3.97e-01
Regulation by c-FLIP	10	1.36e-01	2.79e-01	0.37900	3.46e-01	0.155000	5.80e-02	3.97e-01
Activation of IRF3, IRF7 mediated by TBK1, IKBKE	17	1.09e-01	2.39e-01	0.37800	2.87e-01	0.245000	4.04e-02	7.98e-02
Leishmania infection	144	3.78e-09	8.36e-08	0.37700	2.99e-01	0.231000	6.24e-10	1.78e-06
Parasitic Infection Pathways	144	3.78e-09	8.36e-08	0.37700	2.99e-01	0.231000	6.24e-10	1.78e-06
Glycosphingolipid metabolism	36	1.04e-02	3.67e-02	0.37700	2.59e-01	0.274000	7.08e-03	4.45e-03
GLI3 is processed to GLI3R by the proteasome	57	7.26e-05	6.01e-04	0.37700	-1.84e-01	-0.329000	1.64e-02	1.70e-05
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	53	2.58e-04	1.75e-03	0.37700	-1.97e-01	-0.321000	1.32e-02	5.23e-05
Extracellular matrix organization	242	5.58e-15	5.82e-13	0.37600	3.02e-01	0.224000	6.56e-16	2.16e-09
Lagging Strand Synthesis	20	8.24e-03	3.00e-02	0.37500	3.57e-01	0.114000	5.67e-03	3.78e-01
MHC class II antigen presentation	94	2.37e-06	3.49e-05	0.37500	3.03e-01	0.220000	3.72e-07	2.32e-04
Role of LAT2/NTAL/LAB on calcium mobilization	16	6.91e-02	1.68e-01	0.37500	1.81e-01	0.328000	2.11e-01	2.30e-02
Regulation of PTEN stability and activity	67	1.51e-04	1.13e-03	0.37400	-2.32e-01	-0.293000	1.02e-03	3.32e-05
PI-3K cascade:FGFR3	12	2.18e-01	3.81e-01	0.37400	-2.45e-01	-0.283000	1.41e-01	9.02e-02
Vif-mediated degradation of APOBEC3G	52	2.14e-04	1.51e-03	0.37300	-1.83e-01	-0.325000	2.26e-02	5.04e-05
Interleukin-12 family signaling	46	1.77e-03	7.94e-03	0.37300	3.03e-01	0.217000	3.74e-04	1.10e-02
Homologous DNA Pairing and Strand Exchange	41	3.98e-06	5.58e-05	0.37300	3.67e-01	0.062600	4.71e-05	4.88e-01
Neutrophil degranulation	399	1.14e-21	2.78e-19	0.37300	2.66e-01	0.261000	8.26e-20	4.97e-19
Degradation of GLI1 by the proteasome	57	3.96e-05	3.96e-04	0.37300	-1.66e-01	-0.334000	3.07e-02	1.32e-05
Cobalamin (Cbl, vitamin B12) transport and metabolism	15	1.36e-01	2.79e-01	0.37200	-2.97e-01	-0.225000	4.68e-02	1.31e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	4.16e-02	1.12e-01	0.37200	3.04e-01	0.215000	1.17e-02	7.47e-02
Degradation of AXIN	53	5.78e-04	3.36e-03	0.37000	-2.07e-01	-0.307000	9.30e-03	1.13e-04
L13a-mediated translational silencing of Ceruloplasmin expression	110	2.07e-10	6.85e-09	0.36900	1.36e-01	0.343000	1.35e-02	5.30e-10
MET activates PTK2 signaling	29	6.10e-03	2.37e-02	0.36900	3.31e-01	0.163000	2.04e-03	1.30e-01
Cardiac conduction	96	3.67e-06	5.20e-05	0.36800	-2.20e-01	-0.295000	1.91e-04	6.20e-07
Keratan sulfate/keratin metabolism	32	2.12e-02	6.63e-02	0.36800	2.66e-01	0.254000	9.18e-03	1.29e-02
Golgi-to-ER retrograde transport	116	2.93e-07	4.80e-06	0.36700	2.94e-01	0.220000	4.61e-08	4.38e-05
SCF-beta-TrCP mediated degradation of Emi1	53	1.59e-04	1.17e-03	0.36500	-1.68e-01	-0.324000	3.42e-02	4.56e-05
Interconversion of nucleotide di- and triphosphates	27	6.25e-03	2.43e-02	0.36400	3.35e-01	0.145000	2.62e-03	1.93e-01
Depolymerization of the Nuclear Lamina	15	1.67e-01	3.25e-01	0.36400	2.71e-01	0.244000	6.96e-02	1.02e-01
Synthesis of substrates in N-glycan biosythesis	58	5.73e-04	3.34e-03	0.36300	2.93e-01	0.215000	1.16e-04	4.57e-03
Role of phospholipids in phagocytosis	21	8.43e-02	1.95e-01	0.36200	2.42e-01	0.269000	5.53e-02	3.27e-02
Unfolded Protein Response (UPR)	90	2.59e-05	2.84e-04	0.36200	2.41e-01	0.269000	7.65e-05	1.00e-05
YAP1- and WWTR1 (TAZ)-stimulated gene expression	11	2.04e-01	3.70e-01	0.36100	-3.09e-01	-0.188000	7.64e-02	2.81e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	6.26e-02	1.56e-01	0.36100	3.36e-01	0.131000	2.93e-02	3.98e-01
ROS and RNS production in phagocytes	28	2.93e-02	8.54e-02	0.36000	2.89e-01	0.215000	8.07e-03	4.89e-02
Mitophagy	28	2.86e-03	1.21e-02	0.36000	-3.40e-01	-0.120000	1.86e-03	2.72e-01
Cellular response to starvation	148	1.74e-11	7.07e-10	0.36000	1.58e-01	0.324000	9.26e-04	1.11e-11
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	39	9.03e-06	1.14e-04	0.35900	3.56e-01	0.048500	1.20e-04	6.00e-01
Diseases of DNA Double-Strand Break Repair	39	9.03e-06	1.14e-04	0.35900	3.56e-01	0.048500	1.20e-04	6.00e-01
Gap junction trafficking	29	6.51e-03	2.49e-02	0.35900	3.26e-01	0.151000	2.40e-03	1.59e-01
Autodegradation of the E3 ubiquitin ligase COP1	49	3.73e-04	2.39e-03	0.35900	-1.64e-01	-0.319000	4.78e-02	1.11e-04
ALK mutants bind TKIs	11	6.29e-02	1.56e-01	0.35800	3.48e-01	0.082100	4.55e-02	6.37e-01
Attenuation phase	23	3.42e-02	9.62e-02	0.35800	-3.10e-01	-0.179000	1.02e-02	1.37e-01
Interleukin-4 and Interleukin-13 signaling	83	4.87e-05	4.56e-04	0.35800	2.23e-01	0.280000	4.60e-04	1.05e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	49	3.90e-04	2.45e-03	0.35600	-1.61e-01	-0.318000	5.16e-02	1.20e-04
p53-Independent DNA Damage Response	49	3.90e-04	2.45e-03	0.35600	-1.61e-01	-0.318000	5.16e-02	1.20e-04
p53-Independent G1/S DNA damage checkpoint	49	3.90e-04	2.45e-03	0.35600	-1.61e-01	-0.318000	5.16e-02	1.20e-04
Regulation of FZD by ubiquitination	16	1.64e-01	3.20e-01	0.35600	-2.61e-01	-0.242000	7.13e-02	9.37e-02
Presynaptic phase of homologous DNA pairing and strand exchange	38	3.24e-05	3.30e-04	0.35400	3.49e-01	0.060600	2.00e-04	5.18e-01
Activation of the AP-1 family of transcription factors	10	2.95e-01	4.57e-01	0.35400	-2.10e-01	-0.285000	2.50e-01	1.19e-01
Processive synthesis on the lagging strand	15	1.06e-01	2.34e-01	0.35400	3.11e-01	0.170000	3.73e-02	2.55e-01
Ubiquitin-dependent degradation of Cyclin D	50	5.20e-04	3.09e-03	0.35300	-1.66e-01	-0.311000	4.21e-02	1.41e-04
Degradation of beta-catenin by the destruction complex	83	8.73e-05	7.08e-04	0.35300	-2.31e-01	-0.266000	2.74e-04	2.74e-05
ERK/MAPK targets	22	5.80e-02	1.46e-01	0.35300	-1.95e-01	-0.294000	1.14e-01	1.71e-02
DAP12 signaling	25	4.96e-02	1.30e-01	0.35200	2.82e-01	0.211000	1.46e-02	6.77e-02
Somitogenesis	50	5.99e-05	5.32e-04	0.35200	-1.21e-01	-0.330000	1.38e-01	5.35e-05
Glycogen breakdown (glycogenolysis)	14	1.14e-01	2.45e-01	0.35100	-3.13e-01	-0.160000	4.27e-02	3.01e-01
Polymerase switching on the C-strand of the telomere	26	2.38e-03	1.02e-02	0.35000	3.39e-01	0.086800	2.77e-03	4.44e-01
Gap junction trafficking and regulation	31	6.71e-03	2.55e-02	0.35000	3.16e-01	0.151000	2.35e-03	1.46e-01
Cellular response to hypoxia	72	3.29e-04	2.15e-03	0.35000	-2.27e-01	-0.266000	8.78e-04	9.46e-05
MAPK targets/ Nuclear events mediated by MAP kinases	31	2.71e-02	8.05e-02	0.34900	-2.12e-01	-0.277000	4.08e-02	7.58e-03
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.14e-09	2.98e-08	0.34800	1.24e-01	0.325000	2.40e-02	3.22e-09
Regulation of Complement cascade	28	4.89e-02	1.28e-01	0.34800	2.49e-01	0.244000	2.27e-02	2.57e-02
NIK–>noncanonical NF-kB signaling	57	6.05e-04	3.50e-03	0.34800	-1.86e-01	-0.294000	1.50e-02	1.23e-04
Deposition of new CENPA-containing nucleosomes at the centromere	30	3.06e-05	3.17e-04	0.34800	3.48e-01	-0.002850	9.70e-04	9.78e-01
Nucleosome assembly	30	3.06e-05	3.17e-04	0.34800	3.48e-01	-0.002850	9.70e-04	9.78e-01
MET promotes cell motility	39	1.74e-03	7.84e-03	0.34700	3.15e-01	0.146000	6.57e-04	1.16e-01
Negative regulation of NOTCH4 signaling	54	2.57e-04	1.75e-03	0.34700	-1.56e-01	-0.310000	4.82e-02	8.09e-05
Resolution of Sister Chromatid Cohesion	109	1.56e-14	1.42e-12	0.34700	3.45e-01	0.035500	4.91e-10	5.22e-01
Impaired BRCA2 binding to RAD51	33	2.34e-04	1.61e-03	0.34400	3.39e-01	0.062200	7.63e-04	5.36e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9694676	13	2.27e-01	3.88e-01	0.34400	-2.75e-01	-0.206000	8.61e-02	1.98e-01
PECAM1 interactions	11	2.25e-01	3.88e-01	0.34300	2.97e-01	0.172000	8.76e-02	3.24e-01
Establishment of Sister Chromatid Cohesion	10	2.74e-02	8.10e-02	0.34200	3.42e-01	-0.021300	6.15e-02	9.07e-01
Cross-presentation of soluble exogenous antigens (endosomes)	46	8.58e-04	4.64e-03	0.34200	-1.48e-01	-0.308000	8.29e-02	3.00e-04
Defects in vitamin and cofactor metabolism	20	5.41e-02	1.39e-01	0.34100	-3.04e-01	-0.156000	1.88e-02	2.29e-01
Triglyceride metabolism	24	5.96e-02	1.49e-01	0.34100	-2.80e-01	-0.195000	1.76e-02	9.90e-02
Synthesis of glycosylphosphatidylinositol (GPI)	18	1.15e-01	2.46e-01	0.34100	2.83e-01	0.189000	3.75e-02	1.64e-01
Negative regulation of MAPK pathway	41	1.10e-02	3.85e-02	0.34000	-2.08e-01	-0.269000	2.11e-02	2.87e-03
Influenza Viral RNA Transcription and Replication	135	1.88e-08	3.60e-07	0.33900	1.68e-01	0.294000	7.50e-04	3.78e-09
Stabilization of p53	54	6.09e-04	3.51e-03	0.33800	-1.62e-01	-0.297000	4.00e-02	1.59e-04
Cap-dependent Translation Initiation	118	9.30e-10	2.51e-08	0.33700	1.18e-01	0.316000	2.68e-02	3.08e-09
Eukaryotic Translation Initiation	118	9.30e-10	2.51e-08	0.33700	1.18e-01	0.316000	2.68e-02	3.08e-09
CTNNB1 S33 mutants aren’t phosphorylated	15	2.06e-01	3.70e-01	0.33600	-2.61e-01	-0.212000	7.96e-02	1.56e-01
CTNNB1 S37 mutants aren’t phosphorylated	15	2.06e-01	3.70e-01	0.33600	-2.61e-01	-0.212000	7.96e-02	1.56e-01
CTNNB1 S45 mutants aren’t phosphorylated	15	2.06e-01	3.70e-01	0.33600	-2.61e-01	-0.212000	7.96e-02	1.56e-01
CTNNB1 T41 mutants aren’t phosphorylated	15	2.06e-01	3.70e-01	0.33600	-2.61e-01	-0.212000	7.96e-02	1.56e-01
Signaling by CTNNB1 phospho-site mutants	15	2.06e-01	3.70e-01	0.33600	-2.61e-01	-0.212000	7.96e-02	1.56e-01
Signaling by GSK3beta mutants	15	2.06e-01	3.70e-01	0.33600	-2.61e-01	-0.212000	7.96e-02	1.56e-01
RHO GTPases Activate Formins	123	5.38e-12	2.31e-10	0.33600	3.25e-01	0.085400	4.76e-10	1.02e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	15	2.03e-01	3.69e-01	0.33600	2.64e-01	0.208000	7.70e-02	1.63e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	15	2.03e-01	3.69e-01	0.33600	2.64e-01	0.208000	7.70e-02	1.63e-01
SARS-CoV-1-host interactions	93	6.10e-05	5.36e-04	0.33500	2.11e-01	0.261000	4.41e-04	1.40e-05
Glucagon-type ligand receptors	16	1.32e-01	2.72e-01	0.33400	2.88e-01	0.170000	4.60e-02	2.40e-01
Cytosolic sulfonation of small molecules	18	9.57e-02	2.17e-01	0.33400	2.91e-01	0.163000	3.27e-02	2.30e-01
Polo-like kinase mediated events	14	8.50e-02	1.96e-01	0.33100	3.12e-01	0.111000	4.31e-02	4.72e-01
Dectin-1 mediated noncanonical NF-kB signaling	58	1.26e-03	6.11e-03	0.32900	-1.78e-01	-0.277000	1.93e-02	2.64e-04
Asparagine N-linked glycosylation	275	4.46e-12	1.97e-10	0.32900	2.39e-01	0.227000	1.07e-11	1.09e-10
Beta-catenin phosphorylation cascade	17	1.15e-01	2.46e-01	0.32700	-2.86e-01	-0.158000	4.09e-02	2.59e-01
ECM proteoglycans	61	2.21e-03	9.61e-03	0.32700	2.56e-01	0.203000	5.43e-04	6.04e-03
HDR through Homologous Recombination (HRR)	65	7.43e-06	9.61e-05	0.32700	3.11e-01	0.099300	1.42e-05	1.66e-01
Transferrin endocytosis and recycling	26	2.33e-02	7.12e-02	0.32700	2.97e-01	0.137000	8.83e-03	2.28e-01
PKA-mediated phosphorylation of CREB	18	1.20e-01	2.53e-01	0.32600	-1.68e-01	-0.279000	2.17e-01	4.06e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14	1.31e-01	2.71e-01	0.32600	2.97e-01	0.135000	5.48e-02	3.84e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	70	1.00e-04	7.81e-04	0.32500	-1.49e-01	-0.289000	3.08e-02	2.91e-05
Degradation of the extracellular matrix	104	1.72e-06	2.64e-05	0.32200	2.86e-01	0.150000	4.92e-07	8.46e-03
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	11	1.55e-01	3.05e-01	0.32200	3.05e-01	0.105000	8.02e-02	5.46e-01
Interleukin-7 signaling	17	4.67e-02	1.24e-01	0.32200	-3.08e-01	-0.094200	2.81e-02	5.01e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus	11	3.19e-02	9.12e-02	0.32200	3.21e-01	-0.016600	6.52e-02	9.24e-01
Adrenaline,noradrenaline inhibits insulin secretion	22	8.42e-03	3.06e-02	0.32100	3.15e-01	0.061100	1.05e-02	6.20e-01
Regulation of RUNX1 Expression and Activity	18	1.94e-01	3.59e-01	0.32000	2.26e-01	0.227000	9.69e-02	9.56e-02
FCERI mediated Ca+2 mobilization	29	6.33e-02	1.57e-01	0.32000	2.48e-01	0.202000	2.07e-02	5.96e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1	16	1.63e-01	3.19e-01	0.31900	2.73e-01	0.165000	5.83e-02	2.53e-01
Removal of the Flap Intermediate	14	1.51e-01	3.00e-01	0.31900	2.88e-01	0.137000	6.18e-02	3.73e-01
Activation of SMO	16	2.34e-01	3.94e-01	0.31900	2.31e-01	0.220000	1.09e-01	1.28e-01
Telomere C-strand (Lagging Strand) Synthesis	34	1.17e-03	5.81e-03	0.31800	3.09e-01	0.072600	1.79e-03	4.64e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	2.19e-01	3.83e-01	0.31800	2.83e-01	0.145000	9.00e-02	3.85e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	4.15e-02	1.12e-01	0.31600	3.16e-01	-0.004840	6.93e-02	9.78e-01
Signaling by ERBB2 KD Mutants	23	9.40e-02	2.14e-01	0.31600	-1.77e-01	-0.262000	1.41e-01	2.97e-02
Defective B3GAT3 causes JDSSDHD	16	1.76e-01	3.35e-01	0.31500	2.68e-01	0.165000	6.35e-02	2.52e-01
p130Cas linkage to MAPK signaling for integrins	12	9.27e-02	2.12e-01	0.31500	3.07e-01	0.068700	6.56e-02	6.80e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	182	1.08e-07	1.87e-06	0.31400	2.34e-01	0.210000	5.46e-08	1.03e-06
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	11	2.38e-01	3.99e-01	0.31400	2.83e-01	0.135000	1.04e-01	4.39e-01
Sema3A PAK dependent Axon repulsion	16	2.31e-01	3.93e-01	0.31400	2.43e-01	0.198000	9.18e-02	1.71e-01
Asymmetric localization of PCP proteins	61	2.36e-03	1.01e-02	0.31300	-1.78e-01	-0.258000	1.60e-02	5.04e-04
Neddylation	233	1.94e-09	4.73e-08	0.31300	-2.22e-01	-0.221000	5.64e-09	6.56e-09
Reduction of cytosolic Ca++ levels	10	3.36e-02	9.47e-02	0.31200	5.28e-02	-0.308000	7.72e-01	9.19e-02
FCERI mediated NF-kB activation	78	6.27e-04	3.55e-03	0.31200	-1.86e-01	-0.251000	4.58e-03	1.28e-04
Transcriptional activation of mitochondrial biogenesis	50	8.77e-03	3.18e-02	0.31100	-2.51e-01	-0.183000	2.12e-03	2.51e-02
Influenza Infection	154	8.60e-08	1.53e-06	0.31000	1.61e-01	0.265000	5.53e-04	1.40e-08
Protein methylation	15	2.70e-01	4.29e-01	0.31000	-2.04e-01	-0.234000	1.72e-01	1.17e-01
EML4 and NUDC in mitotic spindle formation	100	2.94e-10	9.52e-09	0.30900	3.07e-01	0.042500	1.19e-07	4.63e-01
Cell surface interactions at the vascular wall	102	5.61e-05	5.15e-04	0.30900	2.54e-01	0.177000	9.69e-06	1.99e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	86	5.30e-10	1.55e-08	0.30900	3.08e-01	0.017100	7.83e-07	7.84e-01
Amplification of signal from the kinetochores	86	5.30e-10	1.55e-08	0.30900	3.08e-01	0.017100	7.83e-07	7.84e-01
Chemokine receptors bind chemokines	28	8.61e-02	1.98e-01	0.30800	2.37e-01	0.197000	2.99e-02	7.09e-02
Processive synthesis on the C-strand of the telomere	19	5.09e-02	1.33e-01	0.30700	2.91e-01	0.096800	2.81e-02	4.65e-01
Extension of Telomeres	49	9.16e-05	7.36e-04	0.30600	2.99e-01	0.064500	2.92e-04	4.35e-01
RHO GTPase Effectors	241	1.84e-14	1.58e-12	0.30600	2.81e-01	0.121000	6.27e-14	1.26e-03
Nuclear Receptor transcription pathway	42	4.36e-03	1.74e-02	0.30500	-2.79e-01	-0.124000	1.76e-03	1.66e-01
Regulation of RUNX2 expression and activity	70	8.81e-04	4.69e-03	0.30500	-1.61e-01	-0.258000	1.96e-02	1.86e-04
Cargo concentration in the ER	28	9.89e-02	2.22e-01	0.30500	2.11e-01	0.220000	5.33e-02	4.41e-02
Hh mutants abrogate ligand secretion	55	6.17e-04	3.52e-03	0.30400	-1.16e-01	-0.281000	1.37e-01	3.18e-04
RUNX2 regulates osteoblast differentiation	21	1.69e-01	3.26e-01	0.30400	2.33e-01	0.195000	6.50e-02	1.21e-01
Biotin transport and metabolism	11	2.74e-02	8.10e-02	0.30300	-2.98e-01	0.057300	8.70e-02	7.42e-01
Metabolism of polyamines	56	8.97e-04	4.74e-03	0.30300	-1.26e-01	-0.276000	1.04e-01	3.56e-04
Signaling by NODAL	14	2.66e-01	4.26e-01	0.30200	-1.67e-01	-0.251000	2.78e-01	1.04e-01
Laminin interactions	29	4.86e-04	2.91e-03	0.30200	4.80e-03	-0.302000	9.64e-01	4.93e-03
Myogenesis	25	1.03e-01	2.30e-01	0.30200	-1.74e-01	-0.246000	1.31e-01	3.32e-02
Integrin cell surface interactions	73	1.34e-03	6.46e-03	0.30000	2.46e-01	0.171000	2.75e-04	1.15e-02
Hh mutants are degraded by ERAD	53	1.62e-03	7.52e-03	0.30000	-1.26e-01	-0.272000	1.13e-01	6.13e-04
trans-Golgi Network Vesicle Budding	68	3.90e-03	1.58e-02	0.30000	2.27e-01	0.195000	1.19e-03	5.39e-03
COPI-mediated anterograde transport	89	8.37e-04	4.54e-03	0.30000	2.17e-01	0.207000	4.10e-04	7.57e-04
Platelet activation, signaling and aggregation	218	3.05e-10	9.68e-09	0.29900	2.58e-01	0.151000	5.49e-11	1.26e-04
Synaptic adhesion-like molecules	16	2.60e-01	4.21e-01	0.29900	1.85e-01	0.235000	2.01e-01	1.04e-01
Activation of G protein gated Potassium channels	18	2.23e-01	3.85e-01	0.29900	2.33e-01	0.187000	8.72e-02	1.70e-01
G protein gated Potassium channels	18	2.23e-01	3.85e-01	0.29900	2.33e-01	0.187000	8.72e-02	1.70e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	18	2.23e-01	3.85e-01	0.29900	2.33e-01	0.187000	8.72e-02	1.70e-01
EPH-Ephrin signaling	84	2.81e-05	2.96e-04	0.29900	2.74e-01	0.120000	1.48e-05	5.83e-02
Other semaphorin interactions	19	2.11e-01	3.76e-01	0.29800	2.29e-01	0.191000	8.37e-02	1.50e-01
Diseases of DNA repair	48	3.15e-05	3.24e-04	0.29700	2.96e-01	0.029100	3.96e-04	7.28e-01
MECP2 regulates neuronal receptors and channels	14	3.34e-02	9.43e-02	0.29700	-5.44e-03	-0.297000	9.72e-01	5.47e-02
Defective B4GALT7 causes EDS, progeroid type	16	2.61e-01	4.22e-01	0.29500	2.36e-01	0.178000	1.03e-01	2.18e-01
Integrin signaling	23	5.31e-02	1.37e-01	0.29500	2.73e-01	0.112000	2.35e-02	3.53e-01
Signaling by BMP	23	5.50e-02	1.40e-01	0.29400	-1.13e-01	-0.272000	3.49e-01	2.40e-02
Signaling by WNT in cancer	29	8.87e-02	2.04e-01	0.29400	-2.35e-01	-0.177000	2.84e-02	9.96e-02
Unblocking of NMDA receptors, glutamate binding and activation	16	2.41e-01	4.02e-01	0.29400	-1.64e-01	-0.244000	2.56e-01	9.14e-02
Biosynthesis of specialized proresolving mediators (SPMs)	14	3.15e-01	4.84e-01	0.29100	1.74e-01	0.234000	2.60e-01	1.30e-01
Downstream TCR signaling	79	1.68e-03	7.66e-03	0.29100	-1.77e-01	-0.231000	6.50e-03	3.81e-04
HDR through MMEJ (alt-NHEJ)	12	1.68e-01	3.26e-01	0.29100	2.78e-01	0.084100	9.50e-02	6.14e-01
Intra-Golgi traffic	41	3.01e-02	8.71e-02	0.29000	1.64e-01	0.239000	6.87e-02	8.11e-03
Formation of the ternary complex, and subsequently, the 43S complex	51	4.62e-04	2.81e-03	0.29000	7.99e-02	0.278000	3.24e-01	5.88e-04
Cilium Assembly	183	5.41e-07	8.76e-06	0.28900	2.29e-01	0.176000	9.49e-08	3.94e-05
Negative regulation of FLT3	13	3.43e-01	5.10e-01	0.28800	2.34e-01	0.169000	1.44e-01	2.93e-01
ABC-family proteins mediated transport	92	1.19e-03	5.83e-03	0.28700	-1.96e-01	-0.209000	1.14e-03	5.26e-04
MAP kinase activation	63	1.00e-02	3.57e-02	0.28600	-1.96e-01	-0.209000	7.18e-03	4.14e-03
Post-chaperonin tubulin folding pathway	16	8.44e-02	1.95e-01	0.28600	2.77e-01	0.071800	5.51e-02	6.19e-01
STAT3 nuclear events downstream of ALK signaling	10	2.46e-01	4.08e-01	0.28600	8.60e-02	0.273000	6.38e-01	1.35e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 9679504	12	3.62e-01	5.29e-01	0.28600	-2.37e-01	-0.159000	1.54e-01	3.42e-01
Translation of Structural Proteins 9694635	57	1.60e-02	5.26e-02	0.28500	2.08e-01	0.195000	6.54e-03	1.08e-02
Response to elevated platelet cytosolic Ca2+	112	8.29e-05	6.75e-04	0.28500	2.37e-01	0.159000	1.46e-05	3.77e-03
Signaling by ERBB2 TMD/JMD mutants	20	1.18e-01	2.52e-01	0.28500	-1.23e-01	-0.257000	3.40e-01	4.68e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	2.86e-01	4.46e-01	0.28500	-2.28e-01	-0.171000	1.15e-01	2.37e-01
HDR through Single Strand Annealing (SSA)	35	3.64e-03	1.49e-02	0.28400	2.77e-01	0.063000	4.57e-03	5.19e-01
Listeria monocytogenes entry into host cells	17	2.93e-01	4.56e-01	0.28400	1.92e-01	0.209000	1.71e-01	1.35e-01
Signaling by CSF1 (M-CSF) in myeloid cells	30	3.82e-02	1.05e-01	0.28300	1.18e-01	0.257000	2.62e-01	1.47e-02
Gap junction assembly	18	2.12e-02	6.63e-02	0.28300	2.83e-01	0.011600	3.77e-02	9.32e-01
RHOC GTPase cycle	70	1.68e-04	1.23e-03	0.28200	2.65e-01	0.098000	1.31e-04	1.56e-01
Amyloid fiber formation	40	2.99e-02	8.66e-02	0.28200	2.41e-01	0.146000	8.42e-03	1.10e-01
Formation of paraxial mesoderm	62	8.80e-04	4.69e-03	0.28100	-1.09e-01	-0.259000	1.37e-01	4.21e-04
Autodegradation of Cdh1 by Cdh1:APC/C	64	1.39e-03	6.64e-03	0.28000	-1.21e-01	-0.252000	9.34e-02	4.81e-04
ER to Golgi Anterograde Transport	138	6.51e-05	5.65e-04	0.28000	1.87e-01	0.208000	1.48e-04	2.55e-05
Long-term potentiation	18	1.37e-01	2.80e-01	0.27900	-1.10e-01	-0.256000	4.18e-01	6.00e-02
Anti-inflammatory response favouring Leishmania parasite infection	63	1.40e-03	6.65e-03	0.27900	2.53e-01	0.117000	5.24e-04	1.07e-01
Leishmania parasite growth and survival	63	1.40e-03	6.65e-03	0.27900	2.53e-01	0.117000	5.24e-04	1.07e-01
STING mediated induction of host immune responses	15	1.49e-01	2.96e-01	0.27900	2.64e-01	0.090400	7.72e-02	5.44e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	1.68e-01	3.25e-01	0.27800	8.99e-02	0.263000	5.60e-01	8.79e-02
Activation of NF-kappaB in B cells	65	1.70e-03	7.72e-03	0.27700	-1.24e-01	-0.248000	8.43e-02	5.41e-04
ERKs are inactivated	13	1.99e-01	3.64e-01	0.27700	-9.15e-02	-0.262000	5.68e-01	1.03e-01
Complement cascade	32	1.01e-01	2.26e-01	0.27600	1.71e-01	0.217000	9.37e-02	3.40e-02
Golgi Associated Vesicle Biogenesis	54	2.22e-02	6.83e-02	0.27600	2.14e-01	0.175000	6.60e-03	2.66e-02
Collagen chain trimerization	36	4.56e-02	1.21e-01	0.27500	2.37e-01	0.140000	1.38e-02	1.47e-01
Platelet calcium homeostasis	23	1.39e-03	6.64e-03	0.27500	6.95e-02	-0.266000	5.64e-01	2.71e-02
ABC transporter disorders	69	8.16e-03	2.99e-02	0.27400	-1.74e-01	-0.213000	1.27e-02	2.27e-03
Signaling by Retinoic Acid	35	9.46e-03	3.40e-02	0.27400	-2.63e-01	-0.077900	7.10e-03	4.25e-01
VLDLR internalisation and degradation	15	2.23e-01	3.85e-01	0.27300	1.16e-01	0.247000	4.38e-01	9.70e-02
RHO GTPases activate CIT	19	1.64e-03	7.59e-03	0.27200	2.33e-01	-0.141000	7.86e-02	2.88e-01
RHOF GTPase cycle	39	2.66e-02	7.95e-02	0.27200	2.42e-01	0.124000	8.80e-03	1.80e-01
FOXO-mediated transcription	56	2.31e-04	1.60e-03	0.27200	-2.66e-01	-0.057600	5.84e-04	4.56e-01
IRAK2 mediated activation of TAK1 complex	10	4.64e-01	6.20e-01	0.27200	-2.26e-01	-0.151000	2.16e-01	4.09e-01
Hedgehog ligand biogenesis	60	1.16e-03	5.79e-03	0.27200	-9.75e-02	-0.254000	1.92e-01	6.80e-04
p53-Dependent G1 DNA Damage Response	61	2.10e-03	9.33e-03	0.27100	-1.12e-01	-0.247000	1.32e-01	8.34e-04
p53-Dependent G1/S DNA damage checkpoint	61	2.10e-03	9.33e-03	0.27100	-1.12e-01	-0.247000	1.32e-01	8.34e-04
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	13	3.02e-01	4.66e-01	0.27100	2.41e-01	0.124000	1.32e-01	4.39e-01
E2F mediated regulation of DNA replication	21	3.58e-02	9.93e-02	0.27100	-4.78e-02	-0.267000	7.04e-01	3.42e-02
HSF1 activation	26	1.15e-01	2.46e-01	0.27100	-2.34e-01	-0.137000	3.92e-02	2.25e-01
COPII-mediated vesicle transport	63	1.39e-02	4.66e-02	0.27100	1.71e-01	0.210000	1.88e-02	3.99e-03
Signaling by NTRK3 (TRKC)	16	3.47e-01	5.15e-01	0.27100	1.80e-01	0.202000	2.13e-01	1.62e-01
Plasma lipoprotein clearance	32	1.25e-01	2.62e-01	0.27000	1.89e-01	0.193000	6.45e-02	5.84e-02
PI-3K cascade:FGFR2	14	4.02e-01	5.67e-01	0.27000	-1.86e-01	-0.196000	2.29e-01	2.04e-01
Defective CFTR causes cystic fibrosis	57	7.36e-03	2.75e-02	0.27000	-1.30e-01	-0.236000	8.88e-02	2.05e-03
Cytochrome c-mediated apoptotic response	13	2.43e-01	4.06e-01	0.26900	-9.95e-02	-0.250000	5.35e-01	1.18e-01
NOTCH4 Intracellular Domain Regulates Transcription	19	2.09e-01	3.74e-01	0.26900	-1.35e-01	-0.232000	3.07e-01	7.98e-02
ER Quality Control Compartment (ERQC)	21	2.40e-01	4.01e-01	0.26900	1.67e-01	0.211000	1.86e-01	9.44e-02
Downstream signaling of activated FGFR4	19	2.45e-01	4.08e-01	0.26900	-1.51e-01	-0.222000	2.55e-01	9.36e-02
Sensory processing of sound by inner hair cells of the cochlea	46	1.18e-02	4.09e-02	0.26800	2.43e-01	0.113000	4.37e-03	1.86e-01
Regulation of gene expression by Hypoxia-inducible Factor	10	6.96e-02	1.69e-01	0.26800	-2.60e-01	0.063400	1.55e-01	7.29e-01
Chromosome Maintenance	92	5.88e-08	1.07e-06	0.26700	2.67e-01	0.019800	1.00e-05	7.43e-01
APC/C:Cdc20 mediated degradation of Securin	66	1.25e-03	6.10e-03	0.26600	-1.04e-01	-0.245000	1.43e-01	5.75e-04
Innate Immune System	828	2.08e-22	6.06e-20	0.26600	1.95e-01	0.181000	2.90e-21	1.19e-18
RAC1 GTPase cycle	174	9.30e-07	1.46e-05	0.26600	2.30e-01	0.134000	1.79e-07	2.27e-03
Regulation of CDH11 Expression and Function	27	7.09e-02	1.71e-01	0.26600	1.08e-01	0.243000	3.30e-01	2.89e-02
Meiotic recombination	26	1.11e-01	2.41e-01	0.26600	2.33e-01	0.127000	3.96e-02	2.62e-01
Transport of vitamins, nucleosides, and related molecules	29	7.37e-02	1.76e-01	0.26400	2.37e-01	0.117000	2.72e-02	2.74e-01
CDC42 GTPase cycle	147	4.71e-05	4.46e-04	0.26400	2.13e-01	0.157000	8.44e-06	1.05e-03
HuR (ELAVL1) binds and stabilizes mRNA	10	4.98e-01	6.41e-01	0.26400	1.53e-01	0.216000	4.03e-01	2.38e-01
Signaling by ERBB2 in Cancer	24	1.51e-01	2.99e-01	0.26400	-1.34e-01	-0.227000	2.56e-01	5.38e-02
Physiological factors	10	1.86e-01	3.49e-01	0.26300	-2.62e-01	-0.027400	1.52e-01	8.81e-01
G alpha (12/13) signalling events	68	1.34e-02	4.55e-02	0.26300	2.02e-01	0.169000	4.03e-03	1.62e-02
Transport to the Golgi and subsequent modification	163	4.94e-05	4.59e-04	0.26200	1.80e-01	0.190000	7.15e-05	2.79e-05
Late SARS-CoV-2 Infection Events	66	1.78e-02	5.78e-02	0.26200	1.90e-01	0.181000	7.69e-03	1.12e-02
Activation of Matrix Metalloproteinases	20	9.89e-02	2.22e-01	0.26200	2.49e-01	0.081100	5.39e-02	5.30e-01
Mitotic Prometaphase	185	3.57e-10	1.11e-08	0.26200	2.50e-01	0.077600	4.58e-09	6.90e-02
Mitotic Spindle Checkpoint	103	6.76e-09	1.37e-07	0.26200	2.62e-01	0.010400	4.52e-06	8.56e-01
G0 and Early G1	24	7.69e-02	1.82e-01	0.26100	2.45e-01	0.090800	3.77e-02	4.41e-01
Assembly of active LPL and LIPC lipase complexes	12	4.22e-01	5.84e-01	0.26100	1.43e-01	0.219000	3.92e-01	1.89e-01
RAC2 GTPase cycle	85	2.94e-03	1.23e-02	0.26100	2.14e-01	0.149000	6.40e-04	1.75e-02
Signaling by NOTCH4	81	2.23e-04	1.55e-03	0.26100	-9.37e-02	-0.244000	1.45e-01	1.51e-04
Maturation of nucleoprotein 9683610	11	1.91e-01	3.57e-01	0.26100	4.22e-02	0.257000	8.09e-01	1.40e-01
Activation of ATR in response to replication stress	31	9.06e-04	4.77e-03	0.26100	2.58e-01	-0.034000	1.28e-02	7.43e-01
Platelet degranulation	108	4.48e-04	2.75e-03	0.26000	2.19e-01	0.141000	8.80e-05	1.13e-02
Insulin receptor recycling	24	6.53e-02	1.60e-01	0.25900	2.47e-01	0.080000	3.64e-02	4.98e-01
SLBP independent Processing of Histone Pre-mRNAs	10	7.62e-02	1.80e-01	0.25900	2.49e-01	-0.069900	1.72e-01	7.02e-01
O-glycosylation of TSR domain-containing proteins	35	1.24e-01	2.61e-01	0.25900	1.85e-01	0.181000	5.85e-02	6.36e-02
p75 NTR receptor-mediated signalling	91	3.81e-03	1.55e-02	0.25900	1.98e-01	0.167000	1.10e-03	6.04e-03
VEGFA-VEGFR2 Pathway	95	1.13e-03	5.67e-03	0.25800	2.18e-01	0.138000	2.38e-04	2.04e-02
RA biosynthesis pathway	15	2.52e-01	4.14e-01	0.25800	-2.35e-01	-0.106000	1.15e-01	4.79e-01
HATs acetylate histones	82	7.24e-05	6.01e-04	0.25800	-2.47e-01	-0.074700	1.12e-04	2.43e-01
G1/S DNA Damage Checkpoints	62	2.15e-03	9.42e-03	0.25800	-9.52e-02	-0.239000	1.95e-01	1.12e-03
Selective autophagy	70	3.39e-03	1.41e-02	0.25700	-2.28e-01	-0.120000	9.88e-04	8.32e-02
Infection with Mycobacterium tuberculosis	25	2.26e-01	3.88e-01	0.25700	1.91e-01	0.172000	9.77e-02	1.37e-01
Regulation of RUNX3 expression and activity	55	6.40e-03	2.46e-02	0.25700	-1.04e-01	-0.235000	1.83e-01	2.58e-03
SUMOylation of intracellular receptors	27	1.35e-01	2.78e-01	0.25700	-2.21e-01	-0.131000	4.71e-02	2.38e-01
MASTL Facilitates Mitotic Progression	10	3.34e-01	5.02e-01	0.25700	-8.13e-02	-0.243000	6.56e-01	1.83e-01
InlB-mediated entry of Listeria monocytogenes into host cell	13	4.62e-01	6.19e-01	0.25600	1.69e-01	0.193000	2.92e-01	2.29e-01
Orc1 removal from chromatin	67	3.72e-04	2.39e-03	0.25600	-7.06e-02	-0.246000	3.18e-01	4.93e-04
UCH proteinases	85	2.35e-03	1.01e-02	0.25600	-1.35e-01	-0.218000	3.13e-02	5.28e-04
Major pathway of rRNA processing in the nucleolus and cytosol	180	2.47e-05	2.73e-04	0.25600	1.68e-01	0.193000	1.01e-04	8.05e-06
Factors involved in megakaryocyte development and platelet production	113	1.41e-05	1.68e-04	0.25500	2.38e-01	0.091400	1.26e-05	9.36e-02
Sphingolipid metabolism	73	7.31e-03	2.74e-02	0.25500	2.12e-01	0.141000	1.72e-03	3.79e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	13	2.70e-01	4.29e-01	0.25300	2.38e-01	0.087500	1.38e-01	5.85e-01
Defective EXT2 causes exostoses 2	13	2.70e-01	4.29e-01	0.25300	2.38e-01	0.087500	1.38e-01	5.85e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	4.64e-04	2.81e-03	0.25300	5.27e-02	0.247000	4.84e-01	1.02e-03
TP53 Regulates Metabolic Genes	81	5.20e-03	2.04e-02	0.25200	-2.09e-01	-0.142000	1.18e-03	2.69e-02
Cell-extracellular matrix interactions	18	1.10e-02	3.85e-02	0.25200	2.41e-01	-0.075600	7.70e-02	5.79e-01
FRS-mediated FGFR4 signaling	14	2.11e-01	3.76e-01	0.25200	-7.35e-02	-0.241000	6.34e-01	1.18e-01
EPHA-mediated growth cone collapse	23	2.61e-03	1.11e-02	0.25200	2.37e-01	-0.086200	4.94e-02	4.74e-01
RNA Polymerase III Transcription Termination	23	2.29e-01	3.91e-01	0.25100	-1.43e-01	-0.207000	2.37e-01	8.60e-02
Removal of the Flap Intermediate from the C-strand	17	1.72e-01	3.30e-01	0.25000	2.37e-01	0.079600	9.07e-02	5.70e-01
RAC3 GTPase cycle	87	6.17e-04	3.52e-03	0.25000	2.27e-01	0.103000	2.50e-04	9.67e-02
Antigen processing: Ubiquitination & Proteasome degradation	292	9.38e-08	1.65e-06	0.25000	-1.87e-01	-0.165000	3.85e-08	1.34e-06
PI-3K cascade:FGFR1	13	4.65e-01	6.20e-01	0.24900	-1.54e-01	-0.196000	3.38e-01	2.20e-01
Nuclear events mediated by NFE2L2	76	5.03e-03	1.98e-02	0.24900	-1.27e-01	-0.214000	5.53e-02	1.25e-03
Signaling by MET	74	1.17e-02	4.07e-02	0.24900	2.00e-01	0.149000	2.96e-03	2.72e-02
Anchoring of the basal body to the plasma membrane	94	3.00e-03	1.26e-02	0.24900	2.03e-01	0.143000	6.56e-04	1.68e-02
Acyl chain remodelling of PE	20	7.15e-02	1.72e-01	0.24800	-2.44e-01	-0.044800	5.87e-02	7.29e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	6.60e-02	1.61e-01	0.24800	1.12e-01	0.221000	2.50e-01	2.35e-02
Elevation of cytosolic Ca2+ levels	13	3.95e-02	1.08e-01	0.24800	8.22e-02	-0.234000	6.08e-01	1.44e-01
Interleukin-17 signaling	66	2.74e-02	8.10e-02	0.24800	-1.73e-01	-0.177000	1.49e-02	1.28e-02
Regulation of KIT signaling	14	4.59e-01	6.15e-01	0.24800	1.87e-01	0.163000	2.26e-01	2.92e-01
RHOA GTPase cycle	142	8.49e-06	1.09e-04	0.24700	2.25e-01	0.104000	3.88e-06	3.32e-02
Reproduction	65	1.58e-02	5.22e-02	0.24700	2.07e-01	0.135000	4.00e-03	5.96e-02
CD28 co-stimulation	30	1.10e-01	2.40e-01	0.24700	1.17e-01	0.217000	2.67e-01	3.96e-02
Metalloprotease DUBs	19	3.49e-01	5.16e-01	0.24700	-1.87e-01	-0.160000	1.58e-01	2.26e-01
Negative regulation of MET activity	19	3.47e-01	5.15e-01	0.24500	1.56e-01	0.190000	2.39e-01	1.53e-01
Mismatch Repair	14	3.73e-01	5.39e-01	0.24500	2.14e-01	0.121000	1.66e-01	4.35e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	12	4.32e-01	5.92e-01	0.24500	1.21e-01	0.213000	4.69e-01	2.01e-01
TCF dependent signaling in response to WNT	159	1.99e-04	1.42e-03	0.24500	-1.83e-01	-0.163000	7.02e-05	4.06e-04
G1/S-Specific Transcription	24	1.29e-01	2.67e-01	0.24400	2.25e-01	0.095800	5.65e-02	4.17e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	47	6.18e-02	1.54e-01	0.24400	-1.42e-01	-0.199000	9.19e-02	1.84e-02
rRNA processing in the nucleus and cytosol	190	4.45e-05	4.27e-04	0.24400	1.64e-01	0.180000	1.02e-04	1.84e-05
Platelet Aggregation (Plug Formation)	30	4.32e-02	1.16e-01	0.24300	2.33e-01	0.069400	2.70e-02	5.11e-01
SCF(Skp2)-mediated degradation of p27/p21	58	3.52e-03	1.45e-02	0.24300	-7.82e-02	-0.230000	3.03e-01	2.40e-03
SARS-CoV-1 Infection	135	4.21e-04	2.60e-03	0.24300	1.44e-01	0.196000	3.97e-03	8.33e-05
Synthesis of IP2, IP, and Ins in the cytosol	12	4.48e-01	6.05e-01	0.24300	-1.23e-01	-0.210000	4.60e-01	2.09e-01
CDK-mediated phosphorylation and removal of Cdc6	69	1.37e-03	6.56e-03	0.24300	-7.93e-02	-0.229000	2.55e-01	9.99e-04
Ub-specific processing proteases	155	2.39e-04	1.64e-03	0.24200	-1.54e-01	-0.187000	9.74e-04	5.96e-05
FGFR2 ligand binding and activation	10	3.97e-01	5.61e-01	0.24200	-8.32e-02	-0.227000	6.49e-01	2.13e-01
Rap1 signalling	13	2.96e-02	8.62e-02	0.24200	1.35e-01	-0.201000	4.00e-01	2.10e-01
Lewis blood group biosynthesis	10	5.59e-01	6.98e-01	0.24200	1.97e-01	0.140000	2.81e-01	4.44e-01
RHOB GTPase cycle	65	1.71e-05	1.96e-04	0.24100	2.41e-01	-0.005200	7.80e-04	9.42e-01
Translation initiation complex formation	58	1.00e-03	5.25e-03	0.24000	4.83e-02	0.235000	5.25e-01	1.93e-03
RHO GTPases activate PAKs	21	6.32e-03	2.44e-02	0.24000	9.12e-02	-0.222000	4.70e-01	7.85e-02
Downstream signaling events of B Cell Receptor (BCR)	78	1.04e-03	5.36e-03	0.24000	-8.55e-02	-0.224000	1.92e-01	6.28e-04
GRB2 events in ERBB2 signaling	14	3.05e-01	4.69e-01	0.23900	-8.98e-02	-0.222000	5.61e-01	1.50e-01
Semaphorin interactions	62	7.39e-03	2.75e-02	0.23900	2.18e-01	0.096900	2.95e-03	1.87e-01
Signaling by Activin	14	4.70e-01	6.23e-01	0.23900	-1.47e-01	-0.188000	3.41e-01	2.23e-01
Regulation of RAS by GAPs	65	1.02e-03	5.30e-03	0.23800	-6.10e-02	-0.230000	3.96e-01	1.32e-03
Condensation of Prophase Chromosomes	19	7.39e-02	1.77e-01	0.23800	2.36e-01	0.024800	7.45e-02	8.52e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	14	9.74e-02	2.20e-01	0.23800	2.38e-01	-0.007140	1.24e-01	9.63e-01
mTORC1-mediated signalling	24	2.61e-01	4.21e-01	0.23700	-1.93e-01	-0.138000	1.01e-01	2.43e-01
Receptor Mediated Mitophagy	11	1.42e-01	2.86e-01	0.23700	-2.36e-01	0.020100	1.75e-01	9.08e-01
Interleukin-6 signaling	10	1.91e-01	3.57e-01	0.23700	-2.37e-01	0.007350	1.95e-01	9.68e-01
Keratan sulfate biosynthesis	26	2.72e-01	4.31e-01	0.23700	1.73e-01	0.162000	1.27e-01	1.54e-01
Regulation of TLR by endogenous ligand	15	4.17e-01	5.83e-01	0.23700	1.31e-01	0.197000	3.80e-01	1.86e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	94	2.75e-05	2.93e-04	0.23500	2.30e-01	0.049900	1.17e-04	4.04e-01
Regulation of Expression and Function of Type II Classical Cadherins	29	1.48e-01	2.95e-01	0.23500	1.13e-01	0.206000	2.93e-01	5.47e-02
Regulation of Homotypic Cell-Cell Adhesion	29	1.48e-01	2.95e-01	0.23500	1.13e-01	0.206000	2.93e-01	5.47e-02
Signaling by PDGF	53	6.77e-02	1.66e-01	0.23400	1.49e-01	0.181000	6.11e-02	2.25e-02
Detoxification of Reactive Oxygen Species	33	2.83e-02	8.31e-02	0.23400	5.32e-02	0.228000	5.97e-01	2.33e-02
TP53 Regulates Transcription of Death Receptors and Ligands	11	1.11e-01	2.40e-01	0.23400	2.29e-01	-0.050300	1.89e-01	7.73e-01
Intrinsic Pathway of Fibrin Clot Formation	12	5.54e-01	6.94e-01	0.23400	-1.57e-01	-0.174000	3.48e-01	2.97e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	27	1.65e-01	3.21e-01	0.23300	-2.06e-01	-0.109000	6.34e-02	3.27e-01
Hemostasis	472	2.52e-16	3.34e-14	0.23300	2.15e-01	0.090500	1.64e-15	7.94e-04
Signaling by FGFR3 in disease	16	3.61e-01	5.28e-01	0.23300	-1.14e-01	-0.203000	4.31e-01	1.60e-01
Defective B3GALTL causes PpS	34	1.94e-01	3.59e-01	0.23200	1.70e-01	0.159000	8.67e-02	1.09e-01
Transcriptional Regulation by VENTX	38	1.56e-01	3.08e-01	0.23200	1.53e-01	0.175000	1.02e-01	6.24e-02
Nicotinamide salvaging	16	5.28e-02	1.37e-01	0.23200	-3.53e-02	0.229000	8.07e-01	1.12e-01
Diseases of metabolism	203	6.70e-05	5.75e-04	0.23200	1.61e-01	0.167000	7.80e-05	4.27e-05
SUMOylation of DNA methylation proteins	16	4.02e-02	1.09e-01	0.23100	-5.68e-02	0.224000	6.94e-01	1.20e-01
Cytosolic iron-sulfur cluster assembly	13	1.38e-01	2.80e-01	0.23100	-1.28e-03	0.231000	9.94e-01	1.49e-01
RHOBTB1 GTPase cycle	23	3.21e-01	4.89e-01	0.23100	-1.78e-01	-0.147000	1.39e-01	2.22e-01
Synthesis of bile acids and bile salts	24	1.00e-01	2.24e-01	0.23100	-2.22e-01	-0.064000	5.97e-02	5.88e-01
LGI-ADAM interactions	11	2.51e-01	4.13e-01	0.23100	-2.86e-02	-0.229000	8.69e-01	1.88e-01
GPER1 signaling	36	1.02e-01	2.27e-01	0.23100	2.02e-01	0.111000	3.58e-02	2.50e-01
Nuclear events stimulated by ALK signaling in cancer	17	4.38e-01	5.96e-01	0.23000	1.49e-01	0.176000	2.87e-01	2.10e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	2.44e-01	4.06e-01	0.23000	-1.65e-01	-0.160000	1.18e-01	1.29e-01
Telomere Extension By Telomerase	21	5.61e-02	1.42e-01	0.23000	2.30e-01	0.013900	6.86e-02	9.12e-01
SARS-CoV-1 activates/modulates innate immune responses	39	1.22e-01	2.58e-01	0.23000	1.90e-01	0.130000	4.03e-02	1.61e-01
Formation of the cornified envelope	23	4.76e-02	1.25e-01	0.22900	2.29e-01	0.018200	5.79e-02	8.80e-01
Keratinization	23	4.76e-02	1.25e-01	0.22900	2.29e-01	0.018200	5.79e-02	8.80e-01
Homology Directed Repair	100	1.79e-05	2.04e-04	0.22900	2.25e-01	0.044400	1.04e-04	4.44e-01
NGF-stimulated transcription	35	7.97e-02	1.88e-01	0.22900	2.09e-01	0.093800	3.25e-02	3.37e-01
Macroautophagy	123	1.59e-04	1.17e-03	0.22900	-2.08e-01	-0.095000	6.68e-05	6.92e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	70	7.24e-04	3.98e-03	0.22900	-5.14e-02	-0.223000	4.57e-01	1.26e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	70	7.24e-04	3.98e-03	0.22900	-5.14e-02	-0.223000	4.57e-01	1.26e-03
Interleukin-35 Signalling	10	5.07e-01	6.51e-01	0.22900	-2.05e-01	-0.101000	2.61e-01	5.82e-01
Signaling by FLT3 fusion proteins	19	2.84e-01	4.45e-01	0.22900	1.03e-01	0.204000	4.37e-01	1.24e-01
SUMOylation of DNA replication proteins	45	1.12e-01	2.42e-01	0.22800	1.78e-01	0.141000	3.84e-02	1.01e-01
Assembly of the pre-replicative complex	88	6.41e-04	3.61e-03	0.22700	-7.38e-02	-0.214000	2.32e-01	5.17e-04
Plasma lipoprotein assembly, remodeling, and clearance	55	7.65e-02	1.81e-01	0.22600	1.47e-01	0.172000	6.01e-02	2.70e-02
KEAP1-NFE2L2 pathway	101	7.74e-03	2.86e-02	0.22600	-1.39e-01	-0.178000	1.62e-02	1.97e-03
Iron uptake and transport	52	7.46e-02	1.78e-01	0.22500	1.82e-01	0.132000	2.29e-02	9.88e-02
Inactivation of CSF3 (G-CSF) signaling	23	3.10e-02	8.93e-02	0.22500	-2.25e-01	0.008430	6.16e-02	9.44e-01
FOXO-mediated transcription of cell cycle genes	16	4.20e-01	5.84e-01	0.22500	-1.90e-01	-0.121000	1.89e-01	4.02e-01
Initial triggering of complement	15	2.65e-01	4.25e-01	0.22500	6.53e-02	0.215000	6.62e-01	1.49e-01
Deactivation of the beta-catenin transactivating complex	39	2.83e-02	8.32e-02	0.22500	-2.16e-01	-0.061000	1.96e-02	5.10e-01
RAF-independent MAPK1/3 activation	20	2.49e-01	4.11e-01	0.22400	-9.17e-02	-0.205000	4.78e-01	1.13e-01
Fatty acid metabolism	143	4.37e-05	4.23e-04	0.22300	-2.05e-01	-0.088200	2.36e-05	6.89e-02
TRAF3-dependent IRF activation pathway	13	4.88e-01	6.35e-01	0.22200	1.14e-01	0.190000	4.77e-01	2.35e-01
Cohesin Loading onto Chromatin	10	2.57e-01	4.17e-01	0.22100	2.21e-01	0.003190	2.25e-01	9.86e-01
TICAM1-dependent activation of IRF3/IRF7	12	4.31e-01	5.92e-01	0.22100	2.03e-01	0.086100	2.23e-01	6.06e-01
Metabolism of carbohydrates	251	1.13e-05	1.39e-04	0.22100	1.36e-01	0.174000	2.09e-04	2.25e-06
Metabolism of nitric oxide: NOS3 activation and regulation	15	3.54e-01	5.21e-01	0.22000	-8.67e-02	-0.203000	5.61e-01	1.74e-01
Non-integrin membrane-ECM interactions	55	1.07e-02	3.76e-02	0.22000	2.10e-01	0.066800	7.15e-03	3.92e-01
Trafficking of GluR2-containing AMPA receptors	14	3.72e-01	5.39e-01	0.21900	8.32e-02	0.203000	5.90e-01	1.89e-01
Sensory processing of sound	50	2.33e-02	7.11e-02	0.21900	2.06e-01	0.076100	1.19e-02	3.52e-01
Downstream signaling of activated FGFR3	19	3.88e-01	5.51e-01	0.21900	-1.21e-01	-0.182000	3.60e-01	1.69e-01
Killing mechanisms	10	1.24e-01	2.61e-01	0.21900	-9.52e-02	0.197000	6.02e-01	2.80e-01
WNT5:FZD7-mediated leishmania damping	10	1.24e-01	2.61e-01	0.21900	-9.52e-02	0.197000	6.02e-01	2.80e-01
Regulation of signaling by CBL	22	2.26e-01	3.88e-01	0.21900	8.72e-02	0.201000	4.79e-01	1.03e-01
RAB GEFs exchange GTP for GDP on RABs	84	2.20e-02	6.78e-02	0.21900	1.33e-01	0.173000	3.49e-02	6.04e-03
Ribosomal scanning and start codon recognition	58	1.54e-03	7.18e-03	0.21800	2.73e-02	0.217000	7.20e-01	4.33e-03
Fanconi Anemia Pathway	35	2.15e-01	3.80e-01	0.21800	1.69e-01	0.138000	8.45e-02	1.57e-01
MAPK6/MAPK4 signaling	83	2.11e-03	9.33e-03	0.21800	-7.56e-02	-0.205000	2.34e-01	1.28e-03
SHC1 events in EGFR signaling	10	2.07e-01	3.71e-01	0.21700	2.15e-01	-0.029800	2.40e-01	8.70e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	4.83e-01	6.34e-01	0.21600	1.94e-01	0.094600	2.44e-01	5.71e-01
RHO GTPases activate KTN1	10	4.40e-01	5.97e-01	0.21600	2.07e-01	0.061700	2.58e-01	7.36e-01
RNA Polymerase III Abortive And Retractive Initiation	41	1.84e-01	3.45e-01	0.21600	-1.50e-01	-0.155000	9.67e-02	8.60e-02
RNA Polymerase III Transcription	41	1.84e-01	3.45e-01	0.21600	-1.50e-01	-0.155000	9.67e-02	8.60e-02
NOTCH3 Intracellular Domain Regulates Transcription	20	4.18e-01	5.84e-01	0.21500	-1.34e-01	-0.169000	3.00e-01	1.92e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	4.15e-03	1.66e-02	0.21500	-8.88e-02	-0.196000	1.53e-01	1.60e-03
Signaling by VEGF	104	9.64e-03	3.45e-02	0.21300	1.73e-01	0.124000	2.33e-03	2.93e-02
Transcriptional regulation of pluripotent stem cells	17	4.98e-01	6.41e-01	0.21200	-1.39e-01	-0.161000	3.22e-01	2.51e-01
RIP-mediated NFkB activation via ZBP1	16	5.06e-01	6.50e-01	0.21200	1.67e-01	0.131000	2.47e-01	3.65e-01
SLC-mediated transmembrane transport	158	1.65e-03	7.59e-03	0.21200	1.39e-01	0.160000	2.56e-03	5.18e-04
Activation of gene expression by SREBF (SREBP)	42	1.07e-02	3.77e-02	0.21200	-2.11e-01	-0.023200	1.82e-02	7.95e-01
Adenylate cyclase inhibitory pathway	12	3.23e-01	4.91e-01	0.21200	-4.03e-02	-0.208000	8.09e-01	2.13e-01
Transcriptional Regulation by E2F6	34	2.37e-01	3.97e-01	0.21200	1.67e-01	0.130000	9.23e-02	1.90e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	15	3.57e-01	5.23e-01	0.21100	-7.53e-02	-0.198000	6.14e-01	1.85e-01
Negative regulation of FGFR4 signaling	23	3.39e-01	5.07e-01	0.21100	-1.15e-01	-0.177000	3.40e-01	1.42e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	72	4.50e-04	2.75e-03	0.21100	-2.28e-02	-0.210000	7.38e-01	2.10e-03
rRNA processing	200	3.91e-04	2.45e-03	0.21100	1.44e-01	0.154000	4.71e-04	1.75e-04
HDACs deacetylate histones	36	2.37e-01	3.97e-01	0.21000	1.38e-01	0.158000	1.51e-01	1.00e-01
Autophagy	138	1.56e-04	1.16e-03	0.21000	-1.94e-01	-0.080200	8.74e-05	1.04e-01
G alpha (q) signalling events	122	3.61e-05	3.63e-04	0.20900	2.03e-01	0.050000	1.08e-04	3.41e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	4.73e-02	1.25e-01	0.20900	1.24e-01	0.168000	7.00e-02	1.37e-02
Sema4D induced cell migration and growth-cone collapse	20	2.00e-02	6.36e-02	0.20800	1.03e-01	-0.181000	4.23e-01	1.61e-01
Transcriptional Regulation by MECP2	49	1.06e-01	2.35e-01	0.20700	-1.11e-01	-0.174000	1.79e-01	3.47e-02
DNA Replication Pre-Initiation	102	2.69e-04	1.82e-03	0.20700	-5.12e-02	-0.200000	3.72e-01	4.82e-04
Amine ligand-binding receptors	10	1.46e-01	2.94e-01	0.20700	1.03e-01	-0.179000	5.74e-01	3.27e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	7.04e-03	2.67e-02	0.20600	-6.77e-02	-0.195000	3.21e-01	4.30e-03
Transport of Mature Transcript to Cytoplasm	81	3.31e-02	9.38e-02	0.20600	1.19e-01	0.168000	6.38e-02	9.08e-03
Signaling by ERBB2 ECD mutants	16	4.95e-01	6.40e-01	0.20600	-1.71e-01	-0.114000	2.36e-01	4.29e-01
Plasma lipoprotein remodeling	19	4.90e-01	6.37e-01	0.20400	1.52e-01	0.136000	2.51e-01	3.04e-01
Cellular response to heat stress	97	1.95e-02	6.23e-02	0.20400	-1.65e-01	-0.121000	5.09e-03	4.03e-02
SARS-CoV Infections	370	7.43e-07	1.19e-05	0.20400	1.26e-01	0.160000	3.19e-05	1.46e-07
Signaling by PDGFRA extracellular domain mutants	12	4.37e-01	5.96e-01	0.20300	6.38e-02	0.193000	7.02e-01	2.48e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	4.37e-01	5.96e-01	0.20300	6.38e-02	0.193000	7.02e-01	2.48e-01
p38MAPK events	13	2.12e-01	3.77e-01	0.20300	2.03e-01	-0.003610	2.05e-01	9.82e-01
Sema4D in semaphorin signaling	24	9.17e-03	3.30e-02	0.20300	1.35e-01	-0.151000	2.51e-01	2.00e-01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	13	3.03e-01	4.67e-01	0.20300	3.13e-02	0.200000	8.45e-01	2.11e-01
RHO GTPases Activate ROCKs	19	3.09e-02	8.92e-02	0.20200	9.71e-02	-0.178000	4.64e-01	1.80e-01
Basigin interactions	22	8.39e-02	1.95e-01	0.20200	2.02e-01	0.004220	1.00e-01	9.73e-01
PI3K Cascade	32	7.53e-02	1.79e-01	0.20200	-1.97e-01	-0.045100	5.40e-02	6.59e-01
Immune System	1574	6.93e-23	2.53e-20	0.20100	1.44e-01	0.140000	6.17e-21	5.72e-20
Regulation of APC/C activators between G1/S and early anaphase	78	6.26e-04	3.55e-03	0.20100	-2.44e-02	-0.199000	7.10e-01	2.39e-03
Gap-filling DNA repair synthesis and ligation in GG-NER	25	1.19e-01	2.53e-01	0.20000	1.97e-01	0.036800	8.89e-02	7.50e-01
G2/M DNA damage checkpoint	56	3.76e-04	2.39e-03	0.20000	1.96e-01	-0.036800	1.10e-02	6.34e-01
Apoptotic cleavage of cellular proteins	35	7.32e-03	2.74e-02	0.20000	1.96e-01	-0.036800	4.47e-02	7.07e-01
P2Y receptors	10	5.25e-01	6.68e-01	0.19900	-6.52e-02	-0.188000	7.21e-01	3.03e-01
RAF/MAP kinase cascade	232	5.25e-06	7.01e-05	0.19900	-8.41e-02	-0.180000	2.76e-02	2.34e-06
Recruitment of NuMA to mitotic centrosomes	85	4.56e-02	1.21e-01	0.19800	1.53e-01	0.126000	1.45e-02	4.52e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	3.64e-01	5.30e-01	0.19800	-1.52e-01	-0.127000	1.64e-01	2.43e-01
SHC-mediated cascade:FGFR4	12	1.98e-01	3.64e-01	0.19800	3.23e-02	-0.195000	8.46e-01	2.42e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	73	6.13e-04	3.52e-03	0.19700	-1.13e-02	-0.197000	8.67e-01	3.60e-03
Miscellaneous transport and binding events	21	2.46e-02	7.40e-02	0.19700	1.69e-01	-0.101000	1.80e-01	4.21e-01
MAPK1/MAPK3 signaling	237	5.99e-06	7.88e-05	0.19700	-8.43e-02	-0.178000	2.56e-02	2.49e-06
Downregulation of ERBB2 signaling	27	3.19e-01	4.87e-01	0.19600	-1.03e-01	-0.167000	3.57e-01	1.33e-01
Insulin processing	20	2.82e-01	4.43e-01	0.19600	1.85e-01	0.062900	1.51e-01	6.27e-01
Cell death signalling via NRAGE, NRIF and NADE	73	8.40e-02	1.95e-01	0.19600	1.40e-01	0.136000	3.80e-02	4.44e-02
Switching of origins to a post-replicative state	87	7.99e-04	4.35e-03	0.19500	-3.43e-02	-0.192000	5.80e-01	1.95e-03
Frs2-mediated activation	11	5.58e-01	6.98e-01	0.19500	-7.86e-02	-0.178000	6.52e-01	3.06e-01
IRF3-mediated induction of type I IFN	12	3.08e-01	4.74e-01	0.19500	1.94e-01	0.012100	2.44e-01	9.42e-01
NOTCH1 Intracellular Domain Regulates Transcription	47	1.75e-01	3.34e-01	0.19500	-1.57e-01	-0.115000	6.25e-02	1.73e-01
Interleukin-1 signaling	106	3.66e-03	1.50e-02	0.19500	-7.80e-02	-0.178000	1.66e-01	1.52e-03
Transcription of E2F targets under negative control by DREAM complex	18	5.34e-01	6.75e-01	0.19400	1.50e-01	0.124000	2.71e-01	3.63e-01
Repression of WNT target genes	14	4.26e-01	5.88e-01	0.19400	-1.83e-01	-0.064400	2.35e-01	6.77e-01
Response of Mtb to phagocytosis	22	4.78e-01	6.29e-01	0.19300	1.44e-01	0.129000	2.43e-01	2.95e-01
Interleukin-15 signaling	13	1.51e-01	3.00e-01	0.19200	-1.83e-01	0.057900	2.53e-01	7.18e-01
Sensory processing of sound by outer hair cells of the cochlea	37	1.14e-01	2.44e-01	0.19100	1.80e-01	0.063800	5.77e-02	5.02e-01
Potential therapeutics for SARS	89	4.52e-02	1.20e-01	0.19100	1.16e-01	0.152000	5.82e-02	1.34e-02
SLC transporter disorders	67	1.12e-01	2.41e-01	0.19100	1.43e-01	0.127000	4.37e-02	7.28e-02
Activation of the pre-replicative complex	29	1.82e-02	5.86e-02	0.19100	1.84e-01	-0.049400	8.59e-02	6.46e-01
CD28 dependent PI3K/Akt signaling	20	1.09e-01	2.39e-01	0.19100	-1.10e-02	0.190000	9.32e-01	1.41e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	21	1.98e-01	3.64e-01	0.19000	3.49e-02	0.187000	7.82e-01	1.38e-01
FRS-mediated FGFR3 signaling	14	3.35e-01	5.02e-01	0.19000	-3.34e-02	-0.187000	8.29e-01	2.25e-01
Telomere Maintenance	69	7.84e-04	4.28e-03	0.19000	1.90e-01	-0.002100	6.31e-03	9.76e-01
activated TAK1 mediates p38 MAPK activation	23	4.78e-01	6.29e-01	0.19000	-1.34e-01	-0.135000	2.65e-01	2.64e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.82e-01	3.44e-01	0.19000	-7.88e-02	0.173000	6.51e-01	3.21e-01
Nuclear Envelope Breakdown	53	1.78e-01	3.38e-01	0.19000	1.43e-01	0.125000	7.23e-02	1.16e-01
Formation of WDR5-containing histone-modifying complexes	42	5.41e-02	1.39e-01	0.19000	-1.84e-01	-0.044900	3.90e-02	6.15e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase	10	6.29e-01	7.60e-01	0.18900	-8.33e-02	-0.170000	6.48e-01	3.52e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	6.28e-01	7.60e-01	0.18900	-1.09e-01	-0.155000	4.96e-01	3.35e-01
Signaling by Rho GTPases	593	1.55e-12	8.06e-11	0.18900	1.71e-01	0.080800	1.46e-12	8.25e-04
Gastrulation	85	8.24e-03	3.00e-02	0.18900	-6.42e-02	-0.178000	3.07e-01	4.66e-03
Packaging Of Telomere Ends	12	4.50e-01	6.06e-01	0.18900	-4.83e-02	-0.182000	7.72e-01	2.74e-01
Regulation of IFNA/IFNB signaling	11	4.86e-01	6.35e-01	0.18800	4.92e-02	0.182000	7.77e-01	2.97e-01
Surfactant metabolism	18	7.57e-02	1.80e-01	0.18800	6.32e-02	-0.177000	6.42e-01	1.94e-01
Signaling by FGFR4	33	3.16e-01	4.84e-01	0.18800	-1.10e-01	-0.153000	2.76e-01	1.30e-01
Diseases of mitotic cell cycle	36	2.36e-01	3.97e-01	0.18800	1.62e-01	0.094800	9.23e-02	3.25e-01
SARS-CoV-2 Infection	263	2.06e-04	1.46e-03	0.18800	1.18e-01	0.146000	1.02e-03	4.84e-05
Regulation of BACH1 activity	11	6.75e-01	7.98e-01	0.18700	-1.54e-01	-0.106000	3.75e-01	5.42e-01
Translesion synthesis by POLI	17	5.22e-01	6.66e-01	0.18700	1.59e-01	0.097500	2.56e-01	4.86e-01
Cytoprotection by HMOX1	58	6.79e-02	1.66e-01	0.18600	-1.69e-01	-0.078700	2.63e-02	3.00e-01
Infectious disease	813	4.24e-11	1.55e-09	0.18600	1.26e-01	0.137000	1.45e-09	4.70e-11
Cyclin E associated events during G1/S transition	80	2.42e-02	7.31e-02	0.18600	-7.75e-02	-0.169000	2.31e-01	9.17e-03
ZBP1(DAI) mediated induction of type I IFNs	19	3.83e-01	5.47e-01	0.18500	1.72e-01	0.070300	1.95e-01	5.96e-01
SUMOylation of transcription factors	16	4.35e-01	5.95e-01	0.18500	6.73e-02	0.173000	6.41e-01	2.32e-01
Synthesis of PC	22	5.46e-02	1.40e-01	0.18500	-1.78e-01	0.050800	1.48e-01	6.80e-01
RORA activates gene expression	18	8.30e-02	1.93e-01	0.18500	-1.75e-01	0.060700	1.99e-01	6.56e-01
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	607	5.86e-12	2.44e-10	0.18500	1.66e-01	0.081400	3.73e-12	6.53e-04
tRNA Aminoacylation	42	1.01e-02	3.59e-02	0.18500	-1.84e-01	0.018500	3.95e-02	8.36e-01
Aflatoxin activation and detoxification	11	2.30e-01	3.92e-01	0.18500	-1.76e-01	0.054300	3.11e-01	7.55e-01
Biosynthesis of DHA-derived SPMs	12	6.20e-01	7.53e-01	0.18400	9.06e-02	0.161000	5.87e-01	3.35e-01
PI Metabolism	77	9.74e-02	2.20e-01	0.18400	1.35e-01	0.126000	4.12e-02	5.61e-02
Bacterial Infection Pathways	61	1.59e-01	3.11e-01	0.18400	1.34e-01	0.126000	7.05e-02	8.77e-02
Transcriptional regulation by RUNX3	95	3.06e-02	8.85e-02	0.18400	-9.67e-02	-0.156000	1.04e-01	8.55e-03
Interleukin receptor SHC signaling	20	1.95e-01	3.59e-01	0.18300	1.90e-02	0.182000	8.83e-01	1.58e-01
Bile acid and bile salt metabolism	27	1.95e-01	3.59e-01	0.18300	-1.76e-01	-0.050300	1.13e-01	6.51e-01
TP53 Regulates Transcription of Cell Death Genes	40	2.94e-01	4.57e-01	0.18300	1.39e-01	0.119000	1.27e-01	1.94e-01
Receptor-type tyrosine-protein phosphatases	13	6.77e-01	7.99e-01	0.18300	1.34e-01	0.124000	4.02e-01	4.37e-01
Aspirin ADME	15	2.11e-01	3.76e-01	0.18300	-1.27e-02	0.182000	9.32e-01	2.21e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.16e-02	6.74e-02	0.18300	-9.85e-02	0.154000	3.94e-01	1.83e-01
MET activates RAP1 and RAC1	11	2.25e-01	3.88e-01	0.18300	1.72e-01	-0.061500	3.23e-01	7.24e-01
Vesicle-mediated transport	592	4.02e-08	7.42e-07	0.18300	1.34e-01	0.125000	3.30e-08	2.51e-07
Metabolism of folate and pterines	17	1.35e-01	2.77e-01	0.18300	-3.41e-02	0.179000	8.08e-01	2.01e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	5.54e-01	6.94e-01	0.18300	1.14e-01	0.142000	3.88e-01	2.83e-01
SARS-CoV-2-host interactions	175	2.16e-03	9.45e-03	0.18200	9.75e-02	0.153000	2.63e-02	4.74e-04
Peptide hormone metabolism	53	9.66e-02	2.19e-01	0.18200	1.65e-01	0.076900	3.84e-02	3.33e-01
Deubiquitination	226	1.42e-03	6.70e-03	0.18200	-1.25e-01	-0.132000	1.23e-03	6.60e-04
TCR signaling	98	3.56e-02	9.90e-02	0.18100	-1.01e-01	-0.151000	8.57e-02	9.83e-03
NRAGE signals death through JNK	56	1.95e-01	3.59e-01	0.18100	1.32e-01	0.124000	8.72e-02	1.10e-01
Meiosis	50	4.01e-02	1.09e-01	0.18100	1.76e-01	0.040900	3.13e-02	6.17e-01
Synthesis, secretion, and deacylation of Ghrelin	10	7.14e-01	8.22e-01	0.18100	1.50e-01	0.101000	4.12e-01	5.80e-01
Interactions of Rev with host cellular proteins	37	3.37e-01	5.04e-01	0.18000	1.35e-01	0.119000	1.55e-01	2.09e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	41	1.47e-01	2.94e-01	0.18000	6.97e-02	0.166000	4.40e-01	6.58e-02
Regulation of innate immune responses to cytosolic DNA	13	6.85e-01	8.05e-01	0.18000	1.33e-01	0.121000	4.06e-01	4.50e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	2.72e-01	4.31e-01	0.18000	1.74e-01	0.043500	1.67e-01	7.30e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	2.72e-01	4.31e-01	0.18000	1.74e-01	0.043500	1.67e-01	7.30e-01
Processing of DNA double-strand break ends	60	2.00e-03	8.90e-03	0.17900	1.78e-01	-0.019500	1.73e-02	7.94e-01
RHOU GTPase cycle	39	3.26e-01	4.94e-01	0.17900	1.19e-01	0.133000	1.98e-01	1.50e-01
RHOBTB GTPase Cycle	35	3.68e-01	5.36e-01	0.17900	-1.21e-01	-0.132000	2.16e-01	1.78e-01
Caspase-mediated cleavage of cytoskeletal proteins	12	2.54e-01	4.15e-01	0.17900	1.75e-01	-0.035600	2.94e-01	8.31e-01
Nucleotide catabolism	26	4.76e-01	6.29e-01	0.17800	1.20e-01	0.132000	2.88e-01	2.45e-01
PCNA-Dependent Long Patch Base Excision Repair	21	1.02e-01	2.27e-01	0.17800	1.76e-01	-0.027500	1.62e-01	8.27e-01
Metabolism of nucleotides	84	5.02e-02	1.31e-01	0.17800	1.53e-01	0.090100	1.53e-02	1.54e-01
Formation of tubulin folding intermediates by CCT/TriC	19	5.90e-02	1.48e-01	0.17800	1.11e-01	-0.139000	4.03e-01	2.95e-01
RAB geranylgeranylation	53	1.92e-01	3.57e-01	0.17800	1.44e-01	0.104000	6.98e-02	1.91e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	13	5.90e-01	7.29e-01	0.17800	1.59e-01	0.078700	3.20e-01	6.23e-01
Separation of Sister Chromatids	172	1.35e-10	4.59e-09	0.17700	1.63e-01	-0.070300	2.37e-04	1.12e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	12	5.33e-01	6.75e-01	0.17700	-5.56e-02	-0.168000	7.39e-01	3.13e-01
RUNX2 regulates bone development	27	3.78e-01	5.43e-01	0.17700	8.79e-02	0.153000	4.29e-01	1.68e-01
FCGR3A-mediated IL10 synthesis	34	1.91e-01	3.57e-01	0.17600	1.65e-01	0.060900	9.53e-02	5.39e-01
FCERI mediated MAPK activation	31	3.44e-01	5.10e-01	0.17600	1.51e-01	0.091100	1.46e-01	3.80e-01
Nucleotide biosynthesis	12	7.05e-01	8.17e-01	0.17600	1.38e-01	0.109000	4.07e-01	5.14e-01
Cell Cycle Checkpoints	236	3.05e-14	2.35e-12	0.17600	1.59e-01	-0.075100	2.75e-05	4.74e-02
Platelet homeostasis	70	1.06e-03	5.39e-03	0.17600	1.63e-02	-0.175000	8.14e-01	1.15e-02
Adherens junctions interactions	46	2.26e-01	3.88e-01	0.17500	1.47e-01	0.095700	8.51e-02	2.62e-01
Signaling by NOTCH3	44	2.30e-01	3.91e-01	0.17500	-9.20e-02	-0.149000	2.91e-01	8.77e-02
Activation of AMPK downstream of NMDARs	20	1.11e-01	2.41e-01	0.17500	3.54e-02	-0.171000	7.84e-01	1.85e-01
Phase I - Functionalization of compounds	65	9.75e-02	2.20e-01	0.17400	-1.52e-01	-0.084400	3.37e-02	2.39e-01
G alpha (z) signalling events	36	1.84e-01	3.45e-01	0.17400	1.63e-01	0.060800	9.07e-02	5.28e-01
Cyclin A:Cdk2-associated events at S phase entry	82	2.94e-02	8.57e-02	0.17400	-6.83e-02	-0.160000	2.85e-01	1.23e-02
IRS-related events triggered by IGF1R	39	2.21e-01	3.85e-01	0.17400	-1.56e-01	-0.077400	9.27e-02	4.03e-01
O-linked glycosylation of mucins	39	2.60e-01	4.21e-01	0.17400	1.50e-01	0.087300	1.04e-01	3.46e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	34	3.26e-01	4.94e-01	0.17400	1.48e-01	0.091300	1.36e-01	3.57e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	8.35e-02	1.94e-01	0.17400	4.23e-02	-0.168000	7.31e-01	1.72e-01
Signaling by ALK	26	2.72e-01	4.31e-01	0.17400	5.51e-02	0.165000	6.27e-01	1.46e-01
NR1H2 and NR1H3-mediated signaling	39	5.39e-03	2.11e-02	0.17300	-8.28e-02	0.152000	3.71e-01	9.95e-02
Synthesis of PIPs at the plasma membrane	49	2.63e-01	4.24e-01	0.17300	1.14e-01	0.131000	1.69e-01	1.13e-01
Sealing of the nuclear envelope (NE) by ESCRT-III	22	4.95e-01	6.40e-01	0.17300	1.46e-01	0.093700	2.36e-01	4.47e-01
Ras activation upon Ca2+ influx through NMDA receptor	16	3.79e-01	5.43e-01	0.17300	-3.69e-02	-0.169000	7.98e-01	2.41e-01
N-Glycan antennae elongation	13	6.01e-01	7.38e-01	0.17200	1.55e-01	0.073700	3.33e-01	6.46e-01
E3 ubiquitin ligases ubiquitinate target proteins	43	1.38e-01	2.80e-01	0.17200	-1.61e-01	-0.059700	6.78e-02	4.98e-01
Interleukin-20 family signaling	13	1.72e-01	3.30e-01	0.17200	-1.44e-01	0.092800	3.67e-01	5.62e-01
Interferon alpha/beta signaling	56	2.30e-01	3.91e-01	0.17100	1.27e-01	0.115000	1.00e-01	1.38e-01
Post-translational modification: synthesis of GPI-anchored proteins	57	1.02e-01	2.28e-01	0.17100	1.56e-01	0.070400	4.21e-02	3.58e-01
GABA receptor activation	37	6.89e-02	1.68e-01	0.17100	1.70e-01	0.015300	7.35e-02	8.72e-01
Cytosolic tRNA aminoacylation	24	1.92e-01	3.57e-01	0.17100	2.08e-02	0.169000	8.60e-01	1.51e-01
Membrane Trafficking	563	7.57e-07	1.20e-05	0.17100	1.21e-01	0.120000	1.05e-06	1.14e-06
Regulation of TP53 Activity through Association with Co-factors	11	7.24e-01	8.25e-01	0.17000	1.40e-01	0.096700	4.21e-01	5.79e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	68	1.05e-03	5.39e-03	0.17000	2.94e-02	-0.168000	6.75e-01	1.69e-02
Negative regulation of FGFR3 signaling	23	4.87e-01	6.35e-01	0.17000	-9.06e-02	-0.144000	4.52e-01	2.32e-01
Formation of TC-NER Pre-Incision Complex	53	1.65e-01	3.22e-01	0.17000	-1.48e-01	-0.082500	6.16e-02	2.99e-01
Cargo trafficking to the periciliary membrane	45	1.66e-01	3.24e-01	0.17000	1.55e-01	0.069100	7.20e-02	4.23e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	6.04e-01	7.39e-01	0.17000	-1.60e-01	-0.057600	3.59e-01	7.41e-01
MAPK family signaling cascades	272	1.69e-05	1.96e-04	0.16900	-6.63e-02	-0.156000	6.03e-02	1.01e-05
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	1.67e-01	3.25e-01	0.16900	1.65e-01	-0.037800	2.39e-01	7.87e-01
RHO GTPase cycle	416	4.11e-06	5.71e-05	0.16900	1.42e-01	0.091200	6.68e-07	1.47e-03
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	4.82e-01	6.34e-01	0.16900	-1.33e-01	-0.104000	2.31e-01	3.50e-01
SHC1 events in ERBB4 signaling	12	2.64e-01	4.25e-01	0.16800	4.88e-02	-0.161000	7.70e-01	3.33e-01
G2/M Checkpoints	123	1.88e-07	3.12e-06	0.16800	8.12e-02	-0.147000	1.20e-01	4.76e-03
TBC/RABGAPs	43	7.86e-03	2.89e-02	0.16800	-5.31e-02	0.160000	5.47e-01	7.03e-02
Early Phase of HIV Life Cycle	14	5.94e-01	7.32e-01	0.16800	1.52e-01	0.072500	3.26e-01	6.39e-01
PTEN Regulation	138	3.27e-02	9.31e-02	0.16800	-1.18e-01	-0.119000	1.68e-02	1.59e-02
Downstream signaling of activated FGFR1	21	5.41e-01	6.82e-01	0.16800	-9.26e-02	-0.140000	4.62e-01	2.68e-01
CLEC7A (Dectin-1) signaling	95	3.95e-02	1.08e-01	0.16700	-7.87e-02	-0.148000	1.85e-01	1.29e-02
RNA Polymerase II Transcription Termination	66	1.91e-01	3.57e-01	0.16700	1.12e-01	0.124000	1.14e-01	8.20e-02
Germ layer formation at gastrulation	10	7.62e-01	8.52e-01	0.16700	9.98e-02	0.134000	5.85e-01	4.62e-01
Purine catabolism	14	6.72e-01	7.95e-01	0.16700	1.38e-01	0.094600	3.72e-01	5.40e-01
Rev-mediated nuclear export of HIV RNA	35	3.84e-01	5.48e-01	0.16600	1.35e-01	0.096500	1.67e-01	3.23e-01
Sphingolipid de novo biosynthesis	37	7.19e-02	1.73e-01	0.16600	1.66e-01	0.010200	8.16e-02	9.15e-01
Post NMDA receptor activation events	63	6.06e-03	2.36e-02	0.16600	5.60e-03	-0.166000	9.39e-01	2.31e-02
MyD88 cascade initiated on plasma membrane	93	8.19e-02	1.91e-01	0.16600	-9.70e-02	-0.134000	1.06e-01	2.55e-02
Toll Like Receptor 10 (TLR10) Cascade	93	8.19e-02	1.91e-01	0.16600	-9.70e-02	-0.134000	1.06e-01	2.55e-02
Toll Like Receptor 5 (TLR5) Cascade	93	8.19e-02	1.91e-01	0.16600	-9.70e-02	-0.134000	1.06e-01	2.55e-02
APC/C-mediated degradation of cell cycle proteins	84	1.18e-03	5.81e-03	0.16500	4.86e-03	-0.165000	9.39e-01	8.81e-03
Regulation of mitotic cell cycle	84	1.18e-03	5.81e-03	0.16500	4.86e-03	-0.165000	9.39e-01	8.81e-03
Neurexins and neuroligins	37	3.76e-01	5.43e-01	0.16500	1.32e-01	0.099200	1.64e-01	2.96e-01
L1CAM interactions	98	2.02e-02	6.41e-02	0.16500	1.53e-01	0.063100	8.93e-03	2.81e-01
mRNA 3’-end processing	57	1.40e-01	2.82e-01	0.16500	7.46e-02	0.148000	3.30e-01	5.41e-02
Uptake and function of anthrax toxins	11	5.94e-01	7.32e-01	0.16500	-1.58e-01	-0.048900	3.64e-01	7.79e-01
Transport of the SLBP Dependant Mature mRNA	36	3.86e-01	5.49e-01	0.16500	1.33e-01	0.098400	1.69e-01	3.07e-01
Nuclear import of Rev protein	34	4.42e-01	5.99e-01	0.16500	1.15e-01	0.118000	2.46e-01	2.36e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	5.98e-02	1.49e-01	0.16400	-2.97e-03	0.164000	9.75e-01	8.80e-02
Effects of PIP2 hydrolysis	23	5.50e-02	1.40e-01	0.16400	1.33e-01	-0.096200	2.68e-01	4.25e-01
Activation of NMDA receptors and postsynaptic events	74	1.23e-02	4.23e-02	0.16400	-2.67e-02	-0.162000	6.91e-01	1.59e-02
Constitutive Signaling by AKT1 E17K in Cancer	26	2.37e-01	3.98e-01	0.16400	-1.61e-01	-0.033600	1.56e-01	7.67e-01
Downstream signaling of activated FGFR2	21	5.68e-01	7.08e-01	0.16400	-9.36e-02	-0.134000	4.58e-01	2.87e-01
Cellular hexose transport	14	6.97e-01	8.12e-01	0.16400	9.86e-02	0.131000	5.23e-01	3.98e-01
AURKA Activation by TPX2	69	1.47e-01	2.94e-01	0.16400	1.36e-01	0.090300	5.03e-02	1.95e-01
Nuclear Pore Complex (NPC) Disassembly	36	3.41e-01	5.09e-01	0.16300	1.40e-01	0.083600	1.45e-01	3.85e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	11	4.21e-01	5.84e-01	0.16300	-1.63e-01	0.005180	3.49e-01	9.76e-01
alpha-linolenic acid (ALA) metabolism	11	4.21e-01	5.84e-01	0.16300	-1.63e-01	0.005180	3.49e-01	9.76e-01
Telomere C-strand synthesis initiation	13	3.32e-01	5.01e-01	0.16300	1.62e-01	-0.015600	3.11e-01	9.23e-01
Diseases of programmed cell death	47	2.70e-01	4.29e-01	0.16300	1.36e-01	0.088700	1.06e-01	2.93e-01
Signaling by FLT3 ITD and TKD mutants	15	6.67e-01	7.91e-01	0.16300	9.16e-02	0.134000	5.39e-01	3.68e-01
Metabolism of porphyrins	20	2.96e-01	4.58e-01	0.16300	-1.61e-01	-0.022200	2.13e-01	8.64e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	5.63e-02	1.43e-01	0.16200	-2.46e-02	0.161000	8.10e-01	1.16e-01
HS-GAG biosynthesis	22	4.38e-01	5.96e-01	0.16200	1.49e-01	0.063800	2.26e-01	6.05e-01
FGFR2 mutant receptor activation	24	3.03e-01	4.67e-01	0.16200	-4.00e-02	-0.157000	7.34e-01	1.83e-01
Signalling to RAS	19	5.45e-01	6.85e-01	0.16200	1.43e-01	0.075600	2.81e-01	5.69e-01
Membrane binding and targetting of GAG proteins	14	3.52e-01	5.19e-01	0.16000	-1.60e-01	0.002920	2.99e-01	9.85e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	14	3.52e-01	5.19e-01	0.16000	-1.60e-01	0.002920	2.99e-01	9.85e-01
RIPK1-mediated regulated necrosis	30	2.47e-01	4.09e-01	0.16000	1.54e-01	0.043500	1.44e-01	6.80e-01
Regulation of necroptotic cell death	30	2.47e-01	4.09e-01	0.16000	1.54e-01	0.043500	1.44e-01	6.80e-01
RNA Polymerase III Transcription Initiation	36	4.25e-01	5.87e-01	0.16000	-1.24e-01	-0.101000	1.98e-01	2.93e-01
Translesion synthesis by REV1	16	5.66e-01	7.06e-01	0.16000	1.46e-01	0.065100	3.11e-01	6.52e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	29	8.37e-02	1.94e-01	0.16000	1.58e-01	-0.021600	1.40e-01	8.40e-01
Regulation of TP53 Activity through Acetylation	29	1.44e-01	2.90e-01	0.16000	8.83e-03	0.160000	9.34e-01	1.37e-01
DNA Damage Recognition in GG-NER	38	3.37e-01	5.04e-01	0.16000	-1.37e-01	-0.081600	1.43e-01	3.84e-01
DNA Double-Strand Break Repair	130	3.19e-04	2.10e-03	0.15900	1.59e-01	0.015400	1.81e-03	7.61e-01
Signaling by FGFR3	33	4.36e-01	5.95e-01	0.15900	-9.27e-02	-0.130000	3.57e-01	1.98e-01
Phosphorylation of the APC/C	20	2.63e-01	4.24e-01	0.15900	1.59e-01	0.007740	2.19e-01	9.52e-01
Arachidonic acid metabolism	37	3.47e-01	5.15e-01	0.15900	1.37e-01	0.080100	1.50e-01	3.99e-01
IGF1R signaling cascade	40	2.57e-01	4.17e-01	0.15800	-1.44e-01	-0.065700	1.16e-01	4.73e-01
FLT3 signaling in disease	27	4.16e-01	5.82e-01	0.15800	6.91e-02	0.142000	5.34e-01	2.01e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	17	6.81e-01	8.01e-01	0.15800	1.19e-01	0.103000	3.94e-01	4.62e-01
Loss of Nlp from mitotic centrosomes	67	1.77e-01	3.35e-01	0.15700	1.32e-01	0.086000	6.28e-02	2.24e-01
Loss of proteins required for interphase microtubule organization from the centrosome	67	1.77e-01	3.35e-01	0.15700	1.32e-01	0.086000	6.28e-02	2.24e-01
Phase 2 - plateau phase	11	7.47e-01	8.42e-01	0.15700	-8.40e-02	-0.133000	6.29e-01	4.47e-01
CaM pathway	31	2.51e-01	4.13e-01	0.15700	-4.26e-02	-0.151000	6.81e-01	1.46e-01
Calmodulin induced events	31	2.51e-01	4.13e-01	0.15700	-4.26e-02	-0.151000	6.81e-01	1.46e-01
SHC-mediated cascade:FGFR1	13	2.65e-01	4.25e-01	0.15700	1.46e-01	-0.057500	3.63e-01	7.19e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.56e-01	3.07e-01	0.15700	7.48e-02	-0.138000	5.94e-01	3.26e-01
RHO GTPases activate PKNs	36	2.18e-02	6.75e-02	0.15700	6.75e-02	-0.141000	4.84e-01	1.42e-01
MAP2K and MAPK activation	36	1.15e-01	2.46e-01	0.15700	1.56e-01	0.015100	1.06e-01	8.75e-01
Centrosome maturation	79	1.68e-01	3.25e-01	0.15600	1.21e-01	0.098400	6.25e-02	1.31e-01
Recruitment of mitotic centrosome proteins and complexes	79	1.68e-01	3.25e-01	0.15600	1.21e-01	0.098400	6.25e-02	1.31e-01
Mitotic Metaphase and Anaphase	216	3.93e-10	1.20e-08	0.15600	1.45e-01	-0.057500	2.40e-04	1.46e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	7.08e-01	8.18e-01	0.15600	6.87e-02	0.140000	6.93e-01	4.22e-01
Insulin receptor signalling cascade	41	2.97e-01	4.60e-01	0.15600	-1.38e-01	-0.073000	1.28e-01	4.19e-01
Rab regulation of trafficking	115	6.27e-03	2.43e-02	0.15600	4.15e-02	0.150000	4.42e-01	5.50e-03
Hedgehog ‘on’ state	82	8.75e-03	3.18e-02	0.15600	-1.75e-02	-0.155000	7.85e-01	1.56e-02
Translation of Structural Proteins 9683701	29	2.72e-01	4.31e-01	0.15600	4.04e-02	0.150000	7.07e-01	1.62e-01
Ion transport by P-type ATPases	42	2.03e-01	3.69e-01	0.15500	-5.37e-02	-0.146000	5.47e-01	1.02e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	20	4.38e-01	5.96e-01	0.15500	-4.70e-02	-0.148000	7.16e-01	2.52e-01
DNA Replication	126	2.82e-05	2.96e-04	0.15500	2.60e-02	-0.153000	6.15e-01	3.03e-03
PPARA activates gene expression	106	3.31e-04	2.16e-03	0.15500	-1.54e-01	0.013500	6.08e-03	8.11e-01
SUMOylation of transcription cofactors	44	1.02e-02	3.61e-02	0.15500	-6.87e-02	0.138000	4.31e-01	1.12e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	41	2.33e-01	3.94e-01	0.15400	-1.43e-01	-0.057300	1.12e-01	5.26e-01
Carboxyterminal post-translational modifications of tubulin	29	3.34e-01	5.02e-01	0.15400	1.45e-01	0.052400	1.76e-01	6.26e-01
SHC-mediated cascade:FGFR3	12	2.75e-01	4.34e-01	0.15400	7.91e-02	-0.132000	6.35e-01	4.29e-01
FLT3 Signaling	34	3.73e-01	5.39e-01	0.15400	7.16e-02	0.136000	4.70e-01	1.70e-01
Interleukin-37 signaling	20	5.31e-01	6.75e-01	0.15300	6.44e-02	0.139000	6.18e-01	2.82e-01
Synthesis of PIPs at the early endosome membrane	16	5.84e-01	7.23e-01	0.15300	1.41e-01	0.059800	3.29e-01	6.79e-01
Mitotic Anaphase	215	8.55e-10	2.40e-08	0.15300	1.42e-01	-0.058100	3.53e-04	1.43e-01
Circadian Clock	66	2.88e-03	1.21e-02	0.15300	-1.48e-01	0.039800	3.83e-02	5.76e-01
NPAS4 regulates expression of target genes	19	2.04e-01	3.69e-01	0.15300	-1.50e-01	0.030500	2.59e-01	8.18e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	7.00e-01	8.12e-01	0.15300	9.33e-02	0.121000	5.18e-01	4.02e-01
Interleukin-6 family signaling	20	1.09e-01	2.39e-01	0.15300	-1.02e-01	0.114000	4.31e-01	3.79e-01
Regulation of expression of SLITs and ROBOs	160	4.22e-03	1.69e-02	0.15200	5.70e-02	0.141000	2.14e-01	2.05e-03
Negative regulation of FGFR1 signaling	25	5.34e-01	6.75e-01	0.15200	-8.09e-02	-0.129000	4.84e-01	2.64e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	43	4.11e-01	5.77e-01	0.15200	1.04e-01	0.111000	2.38e-01	2.08e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	43	3.76e-01	5.43e-01	0.15200	-1.23e-01	-0.088900	1.62e-01	3.13e-01
Acyl chain remodelling of PG	11	7.83e-01	8.65e-01	0.15200	1.21e-01	0.090600	4.86e-01	6.03e-01
Extra-nuclear estrogen signaling	63	1.35e-02	4.56e-02	0.15200	1.51e-01	-0.006040	3.78e-02	9.34e-01
TRAF6 mediated IRF7 activation	15	5.34e-01	6.75e-01	0.15100	4.06e-02	0.146000	7.86e-01	3.28e-01
Protein ubiquitination	63	2.20e-01	3.83e-01	0.15100	-1.27e-01	-0.082500	8.20e-02	2.58e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	23	9.70e-02	2.19e-01	0.15100	7.14e-02	-0.133000	5.53e-01	2.69e-01
Disease	1447	2.39e-12	1.12e-10	0.15100	1.08e-01	0.106000	1.26e-11	2.82e-11
ADORA2B mediated anti-inflammatory cytokines production	33	2.34e-01	3.94e-01	0.15100	1.47e-01	0.035700	1.45e-01	7.22e-01
Downregulation of TGF-beta receptor signaling	26	5.77e-01	7.17e-01	0.15100	-1.17e-01	-0.095100	3.02e-01	4.01e-01
Late endosomal microautophagy	31	1.53e-01	3.02e-01	0.15000	-1.50e-01	-0.005570	1.48e-01	9.57e-01
Regulation of lipid metabolism by PPARalpha	108	4.12e-04	2.56e-03	0.15000	-1.50e-01	0.014900	7.27e-03	7.90e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	4.76e-01	6.29e-01	0.15000	1.47e-01	0.030600	3.08e-01	8.32e-01
Senescence-Associated Secretory Phenotype (SASP)	55	3.22e-01	4.90e-01	0.15000	9.57e-02	0.115000	2.20e-01	1.40e-01
Translesion synthesis by POLK	17	4.87e-01	6.35e-01	0.15000	1.45e-01	0.037200	3.01e-01	7.90e-01
Class A/1 (Rhodopsin-like receptors)	135	1.12e-03	5.66e-03	0.14800	1.47e-01	0.020300	3.23e-03	6.84e-01
Signaling by CSF3 (G-CSF)	28	6.84e-02	1.67e-01	0.14800	-1.33e-01	0.065000	2.22e-01	5.52e-01
Viral Infection Pathways	649	2.64e-06	3.85e-05	0.14800	9.26e-02	0.116000	6.21e-05	5.52e-07
IRS-mediated signalling	36	2.21e-01	3.84e-01	0.14800	-1.44e-01	-0.035900	1.36e-01	7.09e-01
Synthesis of DNA	115	6.78e-05	5.78e-04	0.14800	4.06e-02	-0.142000	4.52e-01	8.66e-03
mRNA decay by 3’ to 5’ exoribonuclease	13	4.94e-01	6.40e-01	0.14700	-1.29e-02	-0.147000	9.36e-01	3.59e-01
Constitutive Signaling by Overexpressed ERBB2	11	7.76e-01	8.62e-01	0.14700	1.24e-01	0.079400	4.77e-01	6.48e-01
Sensory perception of taste	15	6.45e-01	7.76e-01	0.14700	-6.13e-02	-0.133000	6.81e-01	3.71e-01
NRIF signals cell death from the nucleus	16	6.58e-01	7.84e-01	0.14700	1.29e-01	0.069000	3.71e-01	6.33e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	11	7.43e-01	8.41e-01	0.14600	-1.30e-01	-0.066400	4.54e-01	7.03e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	11	7.76e-01	8.62e-01	0.14600	1.24e-01	0.077900	4.78e-01	6.55e-01
Peptide ligand-binding receptors	70	2.09e-02	6.61e-02	0.14600	1.46e-01	0.008720	3.50e-02	9.00e-01
Inhibition of DNA recombination at telomere	26	3.33e-01	5.01e-01	0.14600	-3.25e-02	-0.142000	7.74e-01	2.09e-01
Synthesis of PIPs at the late endosome membrane	11	5.02e-01	6.46e-01	0.14600	1.46e-01	-0.004380	4.03e-01	9.80e-01
TP53 Regulates Transcription of Cell Cycle Genes	43	4.38e-01	5.96e-01	0.14600	9.54e-02	0.110000	2.79e-01	2.12e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	24	2.18e-01	3.81e-01	0.14600	6.38e-03	-0.145000	9.57e-01	2.18e-01
Alpha-protein kinase 1 signaling pathway	11	4.50e-01	6.06e-01	0.14500	-1.43e-01	0.023100	4.10e-01	8.95e-01
Death Receptor Signaling	147	6.53e-02	1.60e-01	0.14500	1.01e-01	0.104000	3.39e-02	3.02e-02
RNA Polymerase III Chain Elongation	18	7.00e-01	8.12e-01	0.14500	-8.88e-02	-0.114000	5.14e-01	4.02e-01
Cell Cycle	583	5.37e-13	3.13e-11	0.14400	1.43e-01	0.015500	3.95e-09	5.24e-01
Apoptotic execution phase	43	1.66e-02	5.42e-02	0.14400	1.19e-01	-0.080400	1.77e-01	3.62e-01
Signaling by SCF-KIT	38	4.96e-01	6.41e-01	0.14400	1.06e-01	0.097000	2.59e-01	3.01e-01
Signaling by high-kinase activity BRAF mutants	32	2.46e-01	4.08e-01	0.14300	1.41e-01	0.026000	1.68e-01	7.99e-01
Regulation of insulin secretion	59	2.17e-02	6.74e-02	0.14300	1.42e-01	-0.013400	5.90e-02	8.59e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	25	4.51e-01	6.06e-01	0.14300	-4.95e-02	-0.134000	6.69e-01	2.47e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	57	2.17e-01	3.81e-01	0.14200	-6.10e-02	-0.129000	4.26e-01	9.31e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants	57	2.17e-01	3.81e-01	0.14200	-6.10e-02	-0.129000	4.26e-01	9.31e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	57	2.17e-01	3.81e-01	0.14200	-6.10e-02	-0.129000	4.26e-01	9.31e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer	57	2.17e-01	3.81e-01	0.14200	-6.10e-02	-0.129000	4.26e-01	9.31e-02
Signaling by NOTCH1 in Cancer	57	2.17e-01	3.81e-01	0.14200	-6.10e-02	-0.129000	4.26e-01	9.31e-02
Termination of O-glycan biosynthesis	13	7.38e-01	8.37e-01	0.14200	-1.23e-01	-0.069900	4.42e-01	6.63e-01
Interferon gamma signaling	73	2.26e-01	3.88e-01	0.14200	1.17e-01	0.080000	8.45e-02	2.37e-01
Pregnenolone biosynthesis	10	8.34e-01	8.94e-01	0.14200	9.38e-02	0.106000	6.07e-01	5.61e-01
Cellular response to chemical stress	183	2.19e-02	6.77e-02	0.14100	-1.19e-01	-0.076700	5.76e-03	7.38e-02
Recognition of DNA damage by PCNA-containing replication complex	29	7.20e-02	1.73e-01	0.14100	1.20e-01	-0.074400	2.65e-01	4.88e-01
Costimulation by the CD28 family	48	1.96e-01	3.61e-01	0.14000	4.10e-02	0.134000	6.24e-01	1.10e-01
Platelet sensitization by LDL	17	7.38e-01	8.37e-01	0.14000	-9.00e-02	-0.107000	5.21e-01	4.46e-01
Processing and activation of SUMO	10	5.17e-01	6.61e-01	0.13900	2.13e-02	-0.137000	9.07e-01	4.52e-01
Cell Cycle, Mitotic	474	1.73e-09	4.43e-08	0.13900	1.37e-01	0.020200	3.31e-07	4.53e-01
SUMOylation of SUMOylation proteins	35	5.10e-01	6.53e-01	0.13800	1.13e-01	0.079600	2.46e-01	4.15e-01
Pre-NOTCH Processing in Golgi	18	3.48e-01	5.15e-01	0.13800	1.38e-01	-0.008260	3.10e-01	9.52e-01
IRAK1 recruits IKK complex	14	7.18e-01	8.22e-01	0.13800	-6.39e-02	-0.123000	6.79e-01	4.27e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14	7.18e-01	8.22e-01	0.13800	-6.39e-02	-0.123000	6.79e-01	4.27e-01
HIV Transcription Initiation	45	4.67e-01	6.20e-01	0.13800	-9.36e-02	-0.101000	2.77e-01	2.41e-01
RNA Polymerase II HIV Promoter Escape	45	4.67e-01	6.20e-01	0.13800	-9.36e-02	-0.101000	2.77e-01	2.41e-01
RNA Polymerase II Promoter Escape	45	4.67e-01	6.20e-01	0.13800	-9.36e-02	-0.101000	2.77e-01	2.41e-01
RNA Polymerase II Transcription Initiation	45	4.67e-01	6.20e-01	0.13800	-9.36e-02	-0.101000	2.77e-01	2.41e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	4.67e-01	6.20e-01	0.13800	-9.36e-02	-0.101000	2.77e-01	2.41e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	4.67e-01	6.20e-01	0.13800	-9.36e-02	-0.101000	2.77e-01	2.41e-01
Chaperonin-mediated protein folding	73	5.00e-02	1.31e-01	0.13700	1.35e-01	0.023100	4.58e-02	7.34e-01
Transport of the SLBP independent Mature mRNA	35	5.38e-01	6.79e-01	0.13600	1.08e-01	0.082700	2.69e-01	3.97e-01
Protein-protein interactions at synapses	59	3.59e-01	5.26e-01	0.13600	1.07e-01	0.083500	1.56e-01	2.67e-01
Signaling by ALK fusions and activated point mutants	53	3.94e-01	5.58e-01	0.13500	8.19e-02	0.108000	3.03e-01	1.74e-01
Signaling by ALK in cancer	53	3.94e-01	5.58e-01	0.13500	8.19e-02	0.108000	3.03e-01	1.74e-01
Diseases associated with O-glycosylation of proteins	53	3.98e-01	5.61e-01	0.13500	1.07e-01	0.082700	1.77e-01	2.98e-01
Signaling by ROBO receptors	199	1.12e-02	3.90e-02	0.13500	6.21e-02	0.120000	1.31e-01	3.51e-03
Suppression of phagosomal maturation	12	6.26e-01	7.58e-01	0.13500	2.47e-02	0.133000	8.82e-01	4.25e-01
Fc epsilon receptor (FCERI) signaling	126	6.35e-02	1.57e-01	0.13500	-6.37e-02	-0.119000	2.18e-01	2.15e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	55	3.78e-01	5.43e-01	0.13500	7.96e-02	0.109000	3.07e-01	1.64e-01
BBSome-mediated cargo-targeting to cilium	21	2.56e-01	4.17e-01	0.13400	1.32e-01	-0.026800	2.96e-01	8.31e-01
SUMOylation of DNA damage response and repair proteins	77	2.94e-01	4.56e-01	0.13400	9.60e-02	0.093600	1.46e-01	1.56e-01
Regulated Necrosis	52	1.19e-01	2.53e-01	0.13400	1.32e-01	0.018800	9.87e-02	8.15e-01
Glycolysis	65	6.39e-02	1.58e-01	0.13400	1.57e-02	0.133000	8.27e-01	6.43e-02
DNA Double Strand Break Response	44	4.93e-01	6.40e-01	0.13300	-1.00e-01	-0.088500	2.51e-01	3.10e-01
AKT phosphorylates targets in the cytosol	14	3.59e-01	5.26e-01	0.13300	-1.25e-01	0.047200	4.19e-01	7.60e-01
GPCR ligand binding	186	5.23e-04	3.09e-03	0.13300	1.32e-01	0.017800	1.94e-03	6.77e-01
Metabolism of Angiotensinogen to Angiotensins	13	3.72e-01	5.39e-01	0.13300	5.56e-02	-0.121000	7.28e-01	4.51e-01
Interleukin-1 family signaling	133	2.03e-02	6.41e-02	0.13300	-4.17e-02	-0.126000	4.07e-01	1.21e-02
NCAM signaling for neurite out-growth	50	5.44e-02	1.40e-01	0.13300	1.32e-01	-0.016700	1.07e-01	8.38e-01
RND3 GTPase cycle	36	2.53e-01	4.14e-01	0.13300	1.31e-01	0.022500	1.75e-01	8.15e-01
SUMOylation of RNA binding proteins	47	3.18e-01	4.86e-01	0.13200	5.35e-02	0.121000	5.26e-01	1.51e-01
Glutathione conjugation	27	3.79e-01	5.43e-01	0.13200	-1.29e-01	-0.026600	2.45e-01	8.11e-01
G1/S Transition	124	8.67e-04	4.67e-03	0.13200	1.55e-02	-0.131000	7.66e-01	1.18e-02
CLEC7A (Dectin-1) induces NFAT activation	11	6.03e-01	7.39e-01	0.13200	1.32e-01	0.006550	4.49e-01	9.70e-01
Gluconeogenesis	29	1.03e-01	2.30e-01	0.13200	-1.14e-01	0.065600	2.86e-01	5.41e-01
G alpha (i) signalling events	169	2.29e-02	7.02e-02	0.13200	1.18e-01	0.057900	7.99e-03	1.95e-01
Drug ADME	59	4.04e-01	5.68e-01	0.13200	9.43e-02	0.091900	2.11e-01	2.23e-01
Pyrimidine salvage	10	8.57e-01	9.08e-01	0.13100	9.59e-02	0.089800	6.00e-01	6.23e-01
Signaling by FGFR2 in disease	34	4.34e-01	5.94e-01	0.13100	-5.16e-02	-0.121000	6.03e-01	2.24e-01
GPCR downstream signalling	352	9.44e-05	7.45e-04	0.13100	1.23e-01	0.045700	7.75e-05	1.42e-01
PIP3 activates AKT signaling	242	2.65e-02	7.95e-02	0.13100	-9.18e-02	-0.093200	1.41e-02	1.27e-02
EGFR downregulation	25	6.24e-01	7.57e-01	0.13100	-6.79e-02	-0.112000	5.57e-01	3.34e-01
Apoptotic factor-mediated response	20	3.60e-01	5.26e-01	0.13100	5.69e-03	-0.130000	9.65e-01	3.13e-01
IL-6-type cytokine receptor ligand interactions	14	3.24e-01	4.93e-01	0.13000	-1.00e-01	0.083000	5.15e-01	5.91e-01
Prefoldin mediated transfer of substrate to CCT/TriC	24	1.48e-01	2.95e-01	0.13000	9.87e-02	-0.084100	4.02e-01	4.76e-01
Intracellular signaling by second messengers	278	1.52e-02	5.08e-02	0.13000	-8.44e-02	-0.098400	1.57e-02	4.85e-03
Retrograde transport at the Trans-Golgi-Network	49	4.04e-01	5.68e-01	0.13000	6.73e-02	0.111000	4.15e-01	1.80e-01
HCMV Early Events	74	2.52e-01	4.14e-01	0.13000	1.11e-01	0.066800	9.90e-02	3.21e-01
Protein folding	79	3.31e-02	9.38e-02	0.12900	1.29e-01	0.008050	4.74e-02	9.02e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	5.29e-01	6.73e-01	0.12900	8.30e-02	0.098300	3.52e-01	2.70e-01
Termination of translesion DNA synthesis	31	3.77e-01	5.43e-01	0.12900	1.25e-01	0.031700	2.30e-01	7.60e-01
Signaling by NOTCH	173	1.11e-02	3.86e-02	0.12900	-4.37e-02	-0.121000	3.22e-01	6.12e-03
Regulation of TP53 Activity through Methylation	19	3.35e-01	5.02e-01	0.12800	-1.26e-01	0.022500	3.41e-01	8.65e-01
DCC mediated attractive signaling	13	3.77e-01	5.43e-01	0.12800	6.78e-02	-0.109000	6.72e-01	4.98e-01
Association of TriC/CCT with target proteins during biosynthesis	34	2.07e-01	3.72e-01	0.12800	-1.20e-04	-0.128000	9.99e-01	1.96e-01
Postmitotic nuclear pore complex (NPC) reformation	27	3.70e-01	5.36e-01	0.12800	1.26e-01	0.018800	2.56e-01	8.66e-01
Negative regulation of FGFR2 signaling	25	6.53e-01	7.80e-01	0.12700	-6.97e-02	-0.107000	5.46e-01	3.56e-01
SARS-CoV-2 modulates autophagy	11	4.30e-01	5.92e-01	0.12700	-8.03e-02	0.098800	6.45e-01	5.70e-01
Signaling by Receptor Tyrosine Kinases	460	9.29e-05	7.41e-04	0.12700	1.14e-01	0.056600	3.04e-05	3.84e-02
Activation of GABAB receptors	30	3.86e-01	5.49e-01	0.12700	1.24e-01	0.029000	2.41e-01	7.84e-01
GABA B receptor activation	30	3.86e-01	5.49e-01	0.12700	1.24e-01	0.029000	2.41e-01	7.84e-01
Disorders of Developmental Biology	12	8.12e-01	8.82e-01	0.12700	1.07e-01	0.067300	5.20e-01	6.86e-01
Disorders of Nervous System Development	12	8.12e-01	8.82e-01	0.12700	1.07e-01	0.067300	5.20e-01	6.86e-01
Loss of function of MECP2 in Rett syndrome	12	8.12e-01	8.82e-01	0.12700	1.07e-01	0.067300	5.20e-01	6.86e-01
Pervasive developmental disorders	12	8.12e-01	8.82e-01	0.12700	1.07e-01	0.067300	5.20e-01	6.86e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	30	6.47e-01	7.77e-01	0.12600	9.54e-02	0.083000	3.66e-01	4.32e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein	30	6.47e-01	7.77e-01	0.12600	9.54e-02	0.083000	3.66e-01	4.32e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	26	1.38e-01	2.80e-01	0.12600	9.07e-02	-0.088100	4.24e-01	4.37e-01
Signaling by GPCR	391	1.49e-05	1.77e-04	0.12600	1.22e-01	0.033800	3.90e-05	2.52e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	15	6.93e-01	8.09e-01	0.12600	1.18e-01	0.044900	4.29e-01	7.64e-01
DAG and IP3 signaling	37	2.55e-01	4.16e-01	0.12500	-1.57e-02	-0.124000	8.69e-01	1.90e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	3.49e-02	9.76e-02	0.12500	-1.20e-01	0.035800	1.23e-01	6.46e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	6.93e-01	8.09e-01	0.12500	-5.84e-02	-0.111000	6.59e-01	4.03e-01
Apoptosis	161	8.92e-04	4.73e-03	0.12500	-2.27e-04	-0.125000	9.96e-01	6.32e-03
Growth hormone receptor signaling	18	4.50e-01	6.06e-01	0.12400	-1.24e-01	0.001230	3.61e-01	9.93e-01
Regulation of IFNG signaling	12	8.47e-01	9.02e-01	0.12400	8.32e-02	0.092200	6.18e-01	5.80e-01
Signaling by NOTCH1	71	3.33e-01	5.01e-01	0.12400	-7.10e-02	-0.102000	3.01e-01	1.38e-01
Erythropoietin activates RAS	13	6.54e-01	7.80e-01	0.12400	2.29e-02	0.122000	8.86e-01	4.46e-01
Signaling by Non-Receptor Tyrosine Kinases	50	3.79e-01	5.43e-01	0.12400	1.11e-01	0.056000	1.76e-01	4.93e-01
Signaling by PTK6	50	3.79e-01	5.43e-01	0.12400	1.11e-01	0.056000	1.76e-01	4.93e-01
Axon guidance	481	1.17e-03	5.81e-03	0.12400	9.72e-02	0.076600	2.75e-04	4.13e-03
eNOS activation	11	4.92e-01	6.39e-01	0.12400	4.76e-02	-0.114000	7.85e-01	5.12e-01
FRS-mediated FGFR2 signaling	16	5.32e-01	6.75e-01	0.12400	-8.00e-03	-0.123000	9.56e-01	3.93e-01
M Phase	341	2.78e-06	3.98e-05	0.12400	1.23e-01	0.010300	9.76e-05	7.45e-01
FRS-mediated FGFR1 signaling	15	4.21e-01	5.84e-01	0.12300	3.19e-02	-0.119000	8.31e-01	4.25e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	36	4.84e-01	6.34e-01	0.12300	5.18e-02	0.111000	5.91e-01	2.49e-01
Hedgehog ‘off’ state	104	2.85e-02	8.34e-02	0.12200	-1.69e-02	-0.121000	7.66e-01	3.29e-02
Cell-Cell communication	119	1.59e-02	5.26e-02	0.12200	1.21e-01	0.014600	2.30e-02	7.83e-01
Synthesis of very long-chain fatty acyl-CoAs	19	3.19e-01	4.87e-01	0.12100	4.18e-02	-0.114000	7.52e-01	3.90e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22	7.48e-01	8.42e-01	0.12100	-9.05e-02	-0.079900	4.62e-01	5.17e-01
Eicosanoid ligand-binding receptors	13	5.02e-01	6.45e-01	0.12100	1.18e-01	-0.026100	4.62e-01	8.71e-01
RHOJ GTPase cycle	53	3.42e-01	5.09e-01	0.12000	1.10e-01	0.048200	1.65e-01	5.44e-01
COPI-independent Golgi-to-ER retrograde traffic	43	5.36e-01	6.77e-01	0.12000	9.85e-02	0.068900	2.64e-01	4.34e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	31	1.57e-01	3.08e-01	0.12000	1.12e-01	-0.043500	2.81e-01	6.75e-01
Sensory Perception	142	3.63e-04	2.34e-03	0.12000	3.44e-02	-0.115000	4.80e-01	1.80e-02
Sensory perception of sweet, bitter, and umami (glutamate) taste	12	6.52e-01	7.79e-01	0.12000	-1.11e-02	-0.120000	9.47e-01	4.73e-01
Toll Like Receptor 3 (TLR3) Cascade	102	1.80e-01	3.40e-01	0.12000	-5.82e-02	-0.105000	3.10e-01	6.82e-02
APC-Cdc20 mediated degradation of Nek2A	25	5.20e-01	6.65e-01	0.12000	1.15e-01	0.032100	3.19e-01	7.82e-01
Nervous system development	501	1.02e-03	5.30e-03	0.11900	9.72e-02	0.069300	2.08e-04	8.17e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25	2.02e-01	3.69e-01	0.11900	1.03e-01	-0.060200	3.75e-01	6.02e-01
RHOG GTPase cycle	71	2.16e-01	3.81e-01	0.11900	1.11e-01	0.042500	1.06e-01	5.36e-01
Nuclear signaling by ERBB4	29	2.01e-01	3.68e-01	0.11900	1.14e-01	-0.034700	2.89e-01	7.46e-01
Netrin-1 signaling	41	2.54e-01	4.15e-01	0.11900	-1.42e-02	-0.118000	8.75e-01	1.91e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	10	6.55e-01	7.82e-01	0.11900	-1.19e-01	0.005080	5.16e-01	9.78e-01
Signaling by Interleukins	369	7.26e-03	2.74e-02	0.11900	9.51e-02	0.071100	1.77e-03	1.93e-02
RNA Pol II CTD phosphorylation and interaction with CE	27	6.93e-01	8.09e-01	0.11900	-9.48e-02	-0.071400	3.94e-01	5.21e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	6.93e-01	8.09e-01	0.11900	-9.48e-02	-0.071400	3.94e-01	5.21e-01
Ca-dependent events	33	2.79e-01	4.39e-01	0.11800	-1.50e-03	-0.118000	9.88e-01	2.41e-01
DNA Damage/Telomere Stress Induced Senescence	32	2.89e-01	4.51e-01	0.11800	1.18e-01	0.000848	2.49e-01	9.93e-01
NFE2L2 regulating anti-oxidant/detoxification enzymes	14	8.30e-01	8.93e-01	0.11800	-7.14e-02	-0.093600	6.44e-01	5.44e-01
Interleukin-2 family signaling	33	2.64e-01	4.25e-01	0.11800	-2.64e-03	0.118000	9.79e-01	2.42e-01
Generation of second messenger molecules	16	8.18e-01	8.87e-01	0.11800	7.78e-02	0.088300	5.90e-01	5.41e-01
Metabolism of water-soluble vitamins and cofactors	110	4.38e-03	1.74e-02	0.11800	-1.15e-01	0.023500	3.69e-02	6.71e-01
Synthesis of PA	30	2.53e-01	4.14e-01	0.11700	-1.16e-01	0.015200	2.70e-01	8.86e-01
Transcriptional regulation by RUNX1	162	1.28e-01	2.67e-01	0.11700	-9.10e-02	-0.073900	4.58e-02	1.05e-01
Cell-cell junction organization	65	3.51e-01	5.19e-01	0.11700	1.02e-01	0.057300	1.54e-01	4.24e-01
Metabolism of amino acids and derivatives	317	4.65e-06	6.40e-05	0.11700	-1.17e-01	0.001310	3.46e-04	9.68e-01
Josephin domain DUBs	10	8.67e-01	9.12e-01	0.11700	-9.74e-02	-0.064900	5.94e-01	7.22e-01
GABA synthesis, release, reuptake and degradation	11	7.00e-01	8.12e-01	0.11700	-1.35e-02	-0.116000	9.38e-01	5.06e-01
Clathrin-mediated endocytosis	127	1.26e-01	2.62e-01	0.11700	1.03e-01	0.055300	4.60e-02	2.82e-01
Nicotinate metabolism	28	1.90e-01	3.56e-01	0.11700	-1.05e-01	0.051600	3.38e-01	6.37e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	7.91e-01	8.70e-01	0.11600	6.16e-02	0.098600	6.70e-01	4.95e-01
Activation of BAD and translocation to mitochondria	14	6.48e-01	7.77e-01	0.11600	1.15e-01	0.015900	4.56e-01	9.18e-01
G-protein mediated events	49	4.34e-02	1.16e-01	0.11600	8.48e-02	-0.079200	3.05e-01	3.38e-01
Translation	292	2.78e-06	3.98e-05	0.11600	-1.15e-01	0.014700	7.48e-04	6.66e-01
Signal transduction by L1	21	2.81e-01	4.41e-01	0.11600	9.99e-02	-0.058400	4.28e-01	6.43e-01
VEGFR2 mediated vascular permeability	27	6.79e-01	8.00e-01	0.11500	9.76e-02	0.061600	3.80e-01	5.80e-01
C-type lectin receptors (CLRs)	121	1.75e-01	3.34e-01	0.11500	-6.03e-02	-0.097900	2.52e-01	6.31e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	6.60e-01	7.84e-01	0.11500	-1.09e-01	-0.036500	4.11e-01	7.83e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	19	6.60e-01	7.84e-01	0.11500	-1.09e-01	-0.036500	4.11e-01	7.83e-01
Resolution of Abasic Sites (AP sites)	38	2.76e-01	4.34e-01	0.11500	1.14e-01	0.007120	2.23e-01	9.40e-01
PERK regulates gene expression	31	6.74e-01	7.97e-01	0.11400	9.19e-02	0.068300	3.76e-01	5.11e-01
Tight junction interactions	17	7.21e-01	8.22e-01	0.11400	-4.31e-02	-0.106000	7.58e-01	4.50e-01
SARS-CoV-2 activates/modulates innate and adaptive immune responses	101	1.92e-01	3.57e-01	0.11400	5.17e-02	0.102000	3.69e-01	7.75e-02
HIV elongation arrest and recovery	32	1.82e-01	3.44e-01	0.11400	-3.99e-02	0.107000	6.96e-01	2.96e-01
Pausing and recovery of HIV elongation	32	1.82e-01	3.44e-01	0.11400	-3.99e-02	0.107000	6.96e-01	2.96e-01
SHC-mediated cascade:FGFR2	14	4.28e-01	5.90e-01	0.11400	9.21e-02	-0.066900	5.51e-01	6.65e-01
Antigen processing-Cross presentation	92	1.24e-01	2.60e-01	0.11400	1.09e-01	0.032400	7.12e-02	5.91e-01
Activation of RAC1	11	7.53e-01	8.45e-01	0.11300	-2.45e-02	-0.111000	8.88e-01	5.25e-01
Cytokine Signaling in Immune system	570	7.11e-04	3.95e-03	0.11300	9.37e-02	0.063400	1.41e-04	1.01e-02
G alpha (s) signalling events	84	2.29e-01	3.91e-01	0.11300	1.03e-01	0.046300	1.03e-01	4.64e-01
Downregulation of ERBB2:ERBB3 signaling	13	8.34e-01	8.94e-01	0.11300	-9.60e-02	-0.059200	5.49e-01	7.12e-01
Cholesterol biosynthesis	27	5.45e-01	6.85e-01	0.11200	-1.08e-01	-0.031500	3.33e-01	7.77e-01
Common Pathway of Fibrin Clot Formation	10	6.70e-01	7.95e-01	0.11200	1.12e-01	-0.010400	5.41e-01	9.55e-01
RNA polymerase II transcribes snRNA genes	71	3.96e-01	5.61e-01	0.11200	-9.34e-02	-0.061700	1.74e-01	3.69e-01
N-glycan antennae elongation in the medial/trans-Golgi	20	7.88e-01	8.69e-01	0.11200	8.85e-02	0.067900	4.93e-01	5.99e-01
Class I MHC mediated antigen processing & presentation	353	1.69e-02	5.53e-02	0.11200	-8.80e-02	-0.068500	4.61e-03	2.75e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	99	2.92e-01	4.55e-01	0.11100	-6.36e-02	-0.091300	2.75e-01	1.17e-01
RET signaling	32	1.52e-01	3.01e-01	0.11100	-7.50e-02	0.082100	4.63e-01	4.22e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane	62	3.52e-02	9.80e-02	0.11100	9.92e-02	-0.049900	1.77e-01	4.97e-01
Mitotic G1 phase and G1/S transition	141	1.08e-03	5.50e-03	0.11100	3.44e-02	-0.105000	4.82e-01	3.10e-02
Initiation of Nuclear Envelope (NE) Reformation	19	4.21e-01	5.84e-01	0.11100	2.62e-02	-0.107000	8.43e-01	4.18e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	38	2.23e-01	3.85e-01	0.11000	-1.10e-01	0.012000	2.42e-01	8.98e-01
Synthesis of PE	12	7.39e-01	8.37e-01	0.11000	2.18e-02	0.108000	8.96e-01	5.17e-01
PLC beta mediated events	45	7.99e-02	1.88e-01	0.11000	6.18e-02	-0.091300	4.74e-01	2.89e-01
Tie2 Signaling	16	7.91e-01	8.70e-01	0.10900	-5.09e-02	-0.096600	7.24e-01	5.03e-01
S Phase	155	2.25e-04	1.56e-03	0.10900	5.84e-02	-0.092300	2.11e-01	4.76e-02
Signaling by WNT	238	8.10e-02	1.90e-01	0.10900	-7.30e-02	-0.081100	5.29e-02	3.15e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	12	7.63e-01	8.52e-01	0.10900	-1.06e-01	-0.026700	5.27e-01	8.73e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	41	2.34e-01	3.94e-01	0.10900	4.80e-03	-0.109000	9.58e-01	2.29e-01
Signaling by RAS mutants	41	2.34e-01	3.94e-01	0.10900	4.80e-03	-0.109000	9.58e-01	2.29e-01
Signaling by moderate kinase activity BRAF mutants	41	2.34e-01	3.94e-01	0.10900	4.80e-03	-0.109000	9.58e-01	2.29e-01
Signaling downstream of RAS mutants	41	2.34e-01	3.94e-01	0.10900	4.80e-03	-0.109000	9.58e-01	2.29e-01
NEP/NS2 Interacts with the Cellular Export Machinery	32	7.06e-01	8.17e-01	0.10800	8.38e-02	0.068700	4.12e-01	5.01e-01
Activated NOTCH1 Transmits Signal to the Nucleus	29	2.32e-01	3.93e-01	0.10800	4.63e-02	-0.097400	6.66e-01	3.64e-01
NF-kB is activated and signals survival	13	8.20e-01	8.88e-01	0.10700	-9.68e-02	-0.045500	5.46e-01	7.76e-01
Regulation of TNFR1 signaling	48	1.74e-01	3.32e-01	0.10700	-1.06e-01	0.010600	2.04e-01	8.99e-01
rRNA modification in the nucleus and cytosol	59	7.40e-02	1.77e-01	0.10600	1.02e-01	-0.030800	1.76e-01	6.83e-01
Prolonged ERK activation events	13	6.05e-01	7.40e-01	0.10600	1.62e-02	-0.105000	9.20e-01	5.11e-01
Chaperone Mediated Autophagy	20	4.24e-01	5.87e-01	0.10600	-1.02e-01	0.027800	4.28e-01	8.30e-01
Programmed Cell Death	188	1.04e-03	5.36e-03	0.10600	1.32e-02	-0.105000	7.56e-01	1.33e-02
ISG15 antiviral mechanism	71	4.95e-01	6.40e-01	0.10500	-7.22e-02	-0.076900	2.93e-01	2.63e-01
Dual Incision in GG-NER	41	3.67e-01	5.35e-01	0.10500	1.04e-01	0.017200	2.49e-01	8.49e-01
Positive epigenetic regulation of rRNA expression	52	5.96e-01	7.34e-01	0.10500	7.81e-02	0.070700	3.30e-01	3.78e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	4.22e-01	5.84e-01	0.10500	1.05e-01	-0.011500	3.75e-01	9.23e-01
O-linked glycosylation	83	3.79e-01	5.43e-01	0.10500	8.83e-02	0.057000	1.64e-01	3.69e-01
Signalling to ERKs	32	2.91e-01	4.54e-01	0.10500	1.03e-01	-0.018400	3.11e-01	8.57e-01
Meiotic synapsis	31	2.03e-01	3.69e-01	0.10500	6.38e-02	-0.082900	5.39e-01	4.24e-01
Cell junction organization	90	2.71e-02	8.05e-02	0.10400	1.02e-01	-0.023900	9.56e-02	6.96e-01
Pausing and recovery of Tat-mediated HIV elongation	30	3.97e-01	5.61e-01	0.10400	-1.04e-03	0.104000	9.92e-01	3.26e-01
Tat-mediated HIV elongation arrest and recovery	30	3.97e-01	5.61e-01	0.10400	-1.04e-03	0.104000	9.92e-01	3.26e-01
Pyroptosis	22	4.52e-01	6.07e-01	0.10300	1.02e-01	-0.015000	4.07e-01	9.03e-01
SUMOylation of chromatin organization proteins	57	2.84e-01	4.44e-01	0.10300	2.00e-02	0.101000	7.94e-01	1.87e-01
NCAM1 interactions	30	2.60e-01	4.21e-01	0.10300	9.35e-02	-0.042000	3.76e-01	6.90e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	5.39e-01	6.79e-01	0.10200	1.02e-01	-0.003080	4.28e-01	9.81e-01
DNA methylation	10	8.66e-01	9.11e-01	0.10200	-4.19e-02	-0.093300	8.18e-01	6.09e-01
MyD88 dependent cascade initiated on endosome	100	3.42e-01	5.09e-01	0.10200	-5.72e-02	-0.084800	3.23e-01	1.43e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	8.64e-01	9.11e-01	0.10200	6.45e-02	0.079400	6.65e-01	5.95e-01
Regulation of CDH11 function	10	8.09e-01	8.82e-01	0.10200	2.13e-02	0.099800	9.07e-01	5.85e-01
Mitotic Prophase	88	4.23e-01	5.86e-01	0.10200	8.04e-02	0.062200	1.93e-01	3.14e-01
Formation of the beta-catenin:TCF transactivating complex	36	4.75e-01	6.28e-01	0.10200	-9.92e-02	-0.022100	3.03e-01	8.19e-01
Nuclear Envelope (NE) Reassembly	66	1.15e-01	2.46e-01	0.10100	1.01e-01	-0.009900	1.57e-01	8.89e-01
Chromatin modifying enzymes	202	6.86e-05	5.78e-04	0.10100	-8.08e-02	0.060900	4.82e-02	1.37e-01
Chromatin organization	202	6.86e-05	5.78e-04	0.10100	-8.08e-02	0.060900	4.82e-02	1.37e-01
IKK complex recruitment mediated by RIP1	23	7.94e-01	8.73e-01	0.10100	8.16e-02	0.059700	4.98e-01	6.20e-01
SUMO E3 ligases SUMOylate target proteins	160	1.45e-01	2.91e-01	0.10100	4.83e-02	0.088600	2.92e-01	5.35e-02
Metabolism of vitamins and cofactors	157	3.92e-02	1.07e-01	0.10100	-9.87e-02	-0.020800	3.31e-02	6.54e-01
Signaling by FGFR1	40	6.48e-01	7.77e-01	0.10100	-5.38e-02	-0.085000	5.56e-01	3.53e-01
TNFR2 non-canonical NF-kB pathway	85	5.60e-02	1.42e-01	0.10000	1.48e-02	-0.099000	8.13e-01	1.15e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	72	4.08e-01	5.73e-01	0.10000	4.60e-02	0.088900	5.00e-01	1.92e-01
Cleavage of the damaged pyrimidine	20	7.19e-01	8.22e-01	0.10000	-3.21e-02	-0.094700	8.04e-01	4.64e-01
Depyrimidination	20	7.19e-01	8.22e-01	0.10000	-3.21e-02	-0.094700	8.04e-01	4.64e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	20	7.19e-01	8.22e-01	0.10000	-3.21e-02	-0.094700	8.04e-01	4.64e-01
Signaling by PDGFR in disease	20	7.11e-01	8.20e-01	0.09960	2.98e-02	0.095000	8.17e-01	4.62e-01
Ca2+ pathway	53	2.20e-01	3.83e-01	0.09950	9.95e-02	-0.001740	2.11e-01	9.83e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	4.75e-01	6.28e-01	0.09930	-7.76e-02	0.061900	5.91e-01	6.68e-01
SUMOylation of ubiquitinylation proteins	39	7.09e-01	8.18e-01	0.09850	6.42e-02	0.074800	4.88e-01	4.19e-01
Glycerophospholipid biosynthesis	102	1.96e-02	6.25e-02	0.09820	-9.29e-02	0.031800	1.05e-01	5.79e-01
Acyl chain remodelling of PS	15	7.63e-01	8.52e-01	0.09820	-9.49e-02	-0.025000	5.24e-01	8.67e-01
Toll Like Receptor 9 (TLR9) Cascade	104	3.16e-01	4.84e-01	0.09810	-4.87e-02	-0.085200	3.91e-01	1.34e-01
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	15	8.78e-01	9.21e-01	0.09810	6.60e-02	0.072600	6.58e-01	6.27e-01
Attachment and Entry 9694614	15	6.99e-01	8.12e-01	0.09770	9.74e-02	0.008300	5.14e-01	9.56e-01
mRNA Capping	29	7.69e-01	8.57e-01	0.09770	-7.71e-02	-0.060000	4.72e-01	5.76e-01
TNFR1-induced NF-kappa-B signaling pathway	33	3.16e-01	4.84e-01	0.09630	-9.33e-02	0.024100	3.54e-01	8.11e-01
Vasopressin regulates renal water homeostasis via Aquaporins	33	3.33e-01	5.01e-01	0.09590	2.02e-02	-0.093700	8.41e-01	3.52e-01
TP53 Regulates Transcription of DNA Repair Genes	61	2.10e-01	3.75e-01	0.09520	-9.46e-05	0.095200	9.99e-01	1.99e-01
Class B/2 (Secretin family receptors)	48	3.26e-01	4.94e-01	0.09510	9.49e-02	0.005920	2.55e-01	9.43e-01
Constitutive Signaling by EGFRvIII	15	8.33e-01	8.94e-01	0.09410	-8.58e-02	-0.038700	5.65e-01	7.95e-01
Signaling by EGFRvIII in Cancer	15	8.33e-01	8.94e-01	0.09410	-8.58e-02	-0.038700	5.65e-01	7.95e-01
Transcriptional Regulation by NPAS4	31	4.98e-01	6.41e-01	0.09410	-9.38e-02	-0.006890	3.66e-01	9.47e-01
Regulation of HSF1-mediated heat shock response	79	5.33e-01	6.75e-01	0.09410	-6.24e-02	-0.070400	3.38e-01	2.80e-01
PRC2 methylates histones and DNA	19	8.12e-01	8.82e-01	0.09390	-4.33e-02	-0.083300	7.44e-01	5.30e-01
Metabolism	1733	3.07e-14	2.35e-12	0.09360	-9.27e-02	-0.013200	2.66e-10	3.70e-01
Signaling by ERBB4	51	1.38e-01	2.80e-01	0.09340	4.51e-02	-0.081800	5.78e-01	3.13e-01
Amino acids regulate mTORC1	48	2.75e-01	4.34e-01	0.09330	-6.29e-03	0.093100	9.40e-01	2.65e-01
Endogenous sterols	18	4.88e-01	6.35e-01	0.09330	-4.95e-02	0.079100	7.16e-01	5.61e-01
Integration of energy metabolism	87	2.46e-01	4.09e-01	0.09300	-2.38e-02	-0.089900	7.01e-01	1.47e-01
Diseases of signal transduction by growth factor receptors and second messengers	391	1.20e-02	4.14e-02	0.09300	-3.94e-02	-0.084200	1.82e-01	4.39e-03
SIRT1 negatively regulates rRNA expression	14	7.43e-01	8.41e-01	0.09250	-8.35e-03	-0.092100	9.57e-01	5.51e-01
Translesion Synthesis by POLH	18	6.83e-01	8.03e-01	0.09230	-8.23e-03	-0.092000	9.52e-01	4.99e-01
Regulation of MECP2 expression and activity	29	8.02e-01	8.80e-01	0.09230	-6.73e-02	-0.063100	5.30e-01	5.57e-01
Cleavage of the damaged purine	15	5.98e-01	7.34e-01	0.09170	3.13e-02	-0.086200	8.34e-01	5.63e-01
Depurination	15	5.98e-01	7.34e-01	0.09170	3.13e-02	-0.086200	8.34e-01	5.63e-01
Recognition and association of DNA glycosylase with site containing an affected purine	15	5.98e-01	7.34e-01	0.09170	3.13e-02	-0.086200	8.34e-01	5.63e-01
Formation of Fibrin Clot (Clotting Cascade)	19	5.41e-01	6.82e-01	0.09150	2.52e-02	-0.088000	8.49e-01	5.07e-01
Antiviral mechanism by IFN-stimulated genes	79	4.29e-01	5.90e-01	0.09150	-4.06e-02	-0.082000	5.33e-01	2.08e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	7.82e-01	8.65e-01	0.09140	-5.00e-02	-0.076500	6.47e-01	4.84e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	33	4.64e-01	6.20e-01	0.09110	5.95e-04	0.091100	9.95e-01	3.65e-01
Potassium Channels	53	3.52e-01	5.19e-01	0.09090	9.03e-02	0.010400	2.56e-01	8.96e-01
Amino acid transport across the plasma membrane	24	5.91e-01	7.29e-01	0.09070	3.80e-03	0.090600	9.74e-01	4.42e-01
Neurotransmitter receptors and postsynaptic signal transmission	138	4.81e-03	1.90e-02	0.09060	5.88e-02	-0.069000	2.34e-01	1.62e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	101	4.32e-01	5.92e-01	0.09030	-5.07e-02	-0.074700	3.79e-01	1.95e-01
Signaling by RAF1 mutants	37	2.67e-01	4.27e-01	0.09010	4.11e-02	-0.080200	6.65e-01	3.99e-01
Glucose metabolism	83	5.69e-02	1.44e-01	0.08980	-3.74e-02	0.081700	5.56e-01	1.99e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	31	5.79e-01	7.18e-01	0.08970	-1.48e-02	-0.088500	8.86e-01	3.94e-01
Retinoid metabolism and transport	28	4.70e-01	6.23e-01	0.08940	8.85e-02	-0.012700	4.18e-01	9.07e-01
Aquaporin-mediated transport	35	4.86e-01	6.35e-01	0.08920	-5.42e-03	-0.089000	9.56e-01	3.62e-01
Plasma lipoprotein assembly	11	8.08e-01	8.82e-01	0.08910	8.86e-02	0.009030	6.11e-01	9.59e-01
RND2 GTPase cycle	36	7.71e-01	8.58e-01	0.08910	5.82e-02	0.067400	5.45e-01	4.84e-01
GAB1 signalosome	13	7.83e-01	8.65e-01	0.08900	-1.05e-02	-0.088400	9.48e-01	5.81e-01
Metabolism of steroid hormones	20	8.56e-01	9.08e-01	0.08820	7.22e-02	0.050700	5.77e-01	6.95e-01
Oncogenic MAPK signaling	75	1.28e-01	2.67e-01	0.08800	1.67e-02	-0.086400	8.03e-01	1.96e-01
Oxidative Stress Induced Senescence	68	4.47e-01	6.05e-01	0.08790	-8.21e-02	-0.031300	2.42e-01	6.55e-01
Regulation of beta-cell development	20	8.49e-01	9.05e-01	0.08790	-7.37e-02	-0.047900	5.68e-01	7.11e-01
Signaling by FGFR2 IIIa TM	19	6.24e-01	7.57e-01	0.08760	9.21e-03	-0.087100	9.45e-01	5.11e-01
Ephrin signaling	19	5.73e-01	7.12e-01	0.08710	8.36e-02	-0.024400	5.28e-01	8.54e-01
RHOBTB2 GTPase cycle	23	7.33e-01	8.33e-01	0.08710	-2.45e-02	-0.083500	8.39e-01	4.88e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	8.04e-01	8.80e-01	0.08700	5.82e-02	0.064700	5.69e-01	5.27e-01
Signaling by NOTCH2	29	6.76e-01	7.98e-01	0.08690	8.35e-02	0.024300	4.37e-01	8.21e-01
Processing of Capped Intronless Pre-mRNA	29	6.07e-01	7.41e-01	0.08680	8.59e-02	0.012200	4.23e-01	9.09e-01
Signaling by NTRKs	122	2.17e-01	3.81e-01	0.08680	8.24e-02	0.027100	1.16e-01	6.05e-01
Budding and maturation of HIV virion	27	7.19e-01	8.22e-01	0.08670	-8.19e-02	-0.028300	4.61e-01	7.99e-01
MyD88-independent TLR4 cascade	106	3.56e-01	5.22e-01	0.08670	-3.78e-02	-0.078000	5.01e-01	1.66e-01
TRIF(TICAM1)-mediated TLR4 signaling	106	3.56e-01	5.22e-01	0.08670	-3.78e-02	-0.078000	5.01e-01	1.66e-01
Intrinsic Pathway for Apoptosis	51	2.18e-01	3.81e-01	0.08630	2.79e-02	-0.081700	7.31e-01	3.13e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	2.17e-01	3.81e-01	0.08620	-6.98e-02	0.050600	4.23e-01	5.61e-01
Pre-NOTCH Expression and Processing	55	6.62e-01	7.86e-01	0.08610	7.08e-02	0.049000	3.64e-01	5.30e-01
Signaling by FGFR4 in disease	10	8.99e-01	9.36e-01	0.08590	-7.92e-02	-0.033300	6.65e-01	8.55e-01
PCP/CE pathway	87	3.33e-01	5.01e-01	0.08540	-2.51e-02	-0.081700	6.86e-01	1.88e-01
Signaling by the B Cell Receptor (BCR)	104	9.55e-02	2.17e-01	0.08520	6.52e-03	-0.085000	9.09e-01	1.35e-01
Estrogen-dependent gene expression	90	5.22e-01	6.66e-01	0.08510	-6.95e-02	-0.049100	2.55e-01	4.21e-01
SHC1 events in ERBB2 signaling	20	5.17e-01	6.61e-01	0.08500	4.49e-02	-0.072200	7.28e-01	5.76e-01
Signaling by Hippo	19	5.23e-01	6.67e-01	0.08500	5.31e-02	-0.066300	6.89e-01	6.17e-01
TGF-beta receptor signaling activates SMADs	46	6.99e-01	8.12e-01	0.08480	7.19e-02	0.044900	3.99e-01	5.98e-01
Base Excision Repair	50	2.08e-01	3.72e-01	0.08460	7.53e-02	-0.038500	3.57e-01	6.38e-01
SUMOylation	166	2.74e-01	4.33e-01	0.08450	4.41e-02	0.072100	3.27e-01	1.10e-01
Acyl chain remodelling of PI	10	7.83e-01	8.65e-01	0.08440	-8.34e-02	0.013300	6.48e-01	9.42e-01
Norepinephrine Neurotransmitter Release Cycle	13	9.20e-01	9.47e-01	0.08340	-5.33e-02	-0.064100	7.39e-01	6.89e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	106	4.85e-01	6.34e-01	0.08270	-4.76e-02	-0.067700	3.97e-01	2.29e-01
Toll Like Receptor 2 (TLR2) Cascade	106	4.85e-01	6.34e-01	0.08270	-4.76e-02	-0.067700	3.97e-01	2.29e-01
Toll Like Receptor TLR1:TLR2 Cascade	106	4.85e-01	6.34e-01	0.08270	-4.76e-02	-0.067700	3.97e-01	2.29e-01
Toll Like Receptor TLR6:TLR2 Cascade	106	4.85e-01	6.34e-01	0.08270	-4.76e-02	-0.067700	3.97e-01	2.29e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	10	9.10e-01	9.40e-01	0.08270	7.54e-02	0.034000	6.80e-01	8.52e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	5.80e-01	7.19e-01	0.08260	6.59e-02	-0.049800	6.38e-01	7.22e-01
Activation of BH3-only proteins	27	4.27e-01	5.88e-01	0.08250	6.78e-02	-0.046900	5.42e-01	6.73e-01
p75NTR signals via NF-kB	16	9.09e-01	9.40e-01	0.08160	5.52e-02	0.060200	7.02e-01	6.77e-01
Anchoring fibril formation	14	6.48e-01	7.77e-01	0.08140	4.76e-02	-0.066000	7.58e-01	6.69e-01
PI3K/AKT Signaling in Cancer	83	5.82e-01	7.20e-01	0.08100	-6.61e-02	-0.046800	2.98e-01	4.61e-01
Cytosolic sensors of pathogen-associated DNA	61	6.87e-01	8.06e-01	0.08070	6.37e-02	0.049400	3.90e-01	5.05e-01
TNF signaling	57	2.69e-01	4.29e-01	0.08060	-7.91e-02	0.015400	3.02e-01	8.41e-01
mRNA Splicing - Minor Pathway	50	7.45e-01	8.42e-01	0.08050	5.27e-02	0.060900	5.20e-01	4.56e-01
tRNA modification in the nucleus and cytosol	43	4.70e-01	6.23e-01	0.08050	8.04e-02	0.002330	3.62e-01	9.79e-01
Free fatty acids regulate insulin secretion	10	7.61e-01	8.52e-01	0.08030	7.38e-02	-0.031800	6.86e-01	8.62e-01
Signaling by Erythropoietin	24	5.06e-01	6.50e-01	0.08010	-3.72e-02	0.070900	7.52e-01	5.48e-01
Metabolism of fat-soluble vitamins	31	6.02e-01	7.38e-01	0.08000	7.98e-02	0.005450	4.42e-01	9.58e-01
Regulation of localization of FOXO transcription factors	11	9.23e-01	9.48e-01	0.07980	6.91e-02	0.039900	6.91e-01	8.19e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	22	8.81e-01	9.22e-01	0.07830	4.88e-02	0.061200	6.92e-01	6.19e-01
Activated NTRK2 signals through FRS2 and FRS3	10	9.47e-01	9.63e-01	0.07830	-5.50e-02	-0.055700	7.63e-01	7.60e-01
Signaling by EGFR in Cancer	21	8.62e-01	9.11e-01	0.07810	-3.87e-02	-0.067800	7.59e-01	5.91e-01
Regulation of PLK1 Activity at G2/M Transition	85	4.80e-01	6.31e-01	0.07800	7.17e-02	0.030700	2.53e-01	6.25e-01
Processing of Capped Intron-Containing Pre-mRNA	278	2.29e-01	3.91e-01	0.07780	5.40e-02	0.056000	1.22e-01	1.09e-01
Transcriptional regulation of white adipocyte differentiation	82	1.56e-01	3.07e-01	0.07760	-7.51e-02	0.019600	2.40e-01	7.59e-01
ER-Phagosome pathway	79	1.21e-01	2.55e-01	0.07700	3.93e-02	-0.066200	5.46e-01	3.09e-01
Signaling by BRAF and RAF1 fusions	59	2.59e-01	4.21e-01	0.07680	2.19e-02	-0.073600	7.71e-01	3.28e-01
Methylation	12	7.27e-01	8.28e-01	0.07670	-6.65e-02	0.038300	6.90e-01	8.18e-01
Assembly Of The HIV Virion	16	6.44e-01	7.75e-01	0.07640	-5.95e-02	0.047800	6.80e-01	7.41e-01
Adaptive Immune System	644	4.02e-02	1.09e-01	0.07610	5.12e-02	0.056200	2.74e-02	1.54e-02
HCMV Infection	97	6.09e-01	7.43e-01	0.07600	5.49e-02	0.052500	3.50e-01	3.72e-01
Nuclear Events (kinase and transcription factor activation)	57	2.14e-01	3.80e-01	0.07550	4.95e-02	-0.057100	5.18e-01	4.56e-01
Generic Transcription Pathway	1076	1.36e-05	1.64e-04	0.07510	-7.31e-02	-0.016900	5.93e-05	3.53e-01
Transmission across Chemical Synapses	182	2.37e-02	7.18e-02	0.07500	1.71e-02	-0.073100	6.91e-01	8.96e-02
Signaling by cytosolic FGFR1 fusion mutants	18	6.87e-01	8.06e-01	0.07500	-1.75e-02	0.072900	8.98e-01	5.92e-01
Export of Viral Ribonucleoproteins from Nucleus	33	8.45e-01	9.02e-01	0.07470	5.70e-02	0.048200	5.71e-01	6.32e-01
Downstream signal transduction	28	6.13e-01	7.47e-01	0.07460	-6.12e-03	0.074300	9.55e-01	4.96e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	21	5.88e-01	7.28e-01	0.07440	3.92e-02	-0.063200	7.56e-01	6.16e-01
MET receptor recycling	10	8.39e-01	8.98e-01	0.07430	7.40e-02	-0.006700	6.85e-01	9.71e-01
Phospholipid metabolism	178	7.25e-02	1.74e-01	0.07290	4.32e-04	0.072900	9.92e-01	9.41e-02
Fatty acyl-CoA biosynthesis	31	6.88e-01	8.06e-01	0.07280	-1.04e-02	-0.072100	9.20e-01	4.87e-01
Signaling by NTRK1 (TRKA)	106	3.16e-01	4.84e-01	0.07260	7.12e-02	0.014500	2.06e-01	7.96e-01
MET activates RAS signaling	11	8.57e-01	9.08e-01	0.07210	7.20e-02	0.002380	6.79e-01	9.89e-01
Diseases of carbohydrate metabolism	29	6.97e-01	8.12e-01	0.07200	7.93e-03	0.071600	9.41e-01	5.05e-01
Cargo recognition for clathrin-mediated endocytosis	88	6.16e-01	7.50e-01	0.07170	6.06e-02	0.038300	3.26e-01	5.35e-01
Constitutive Signaling by Aberrant PI3K in Cancer	56	7.14e-01	8.22e-01	0.07160	-3.49e-02	-0.062500	6.52e-01	4.19e-01
Nonhomologous End-Joining (NHEJ)	34	6.91e-01	8.09e-01	0.07120	-1.28e-02	-0.070100	8.98e-01	4.80e-01
Paracetamol ADME	19	7.68e-01	8.57e-01	0.07120	1.46e-03	0.071200	9.91e-01	5.91e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	8.72e-01	9.16e-01	0.07060	5.93e-02	0.038400	6.01e-01	7.35e-01
Early SARS-CoV-2 Infection Events	32	8.36e-01	8.96e-01	0.07010	-3.54e-02	-0.060500	7.29e-01	5.53e-01
Toll-like Receptor Cascades	154	4.17e-01	5.83e-01	0.07000	6.10e-02	0.034400	1.92e-01	4.62e-01
Inositol phosphate metabolism	42	8.32e-01	8.94e-01	0.06990	-4.74e-02	-0.051400	5.95e-01	5.64e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	7.20e-01	8.22e-01	0.06970	-2.01e-03	0.069600	9.87e-01	5.63e-01
Regulation of PTEN gene transcription	60	6.39e-01	7.70e-01	0.06960	2.45e-02	0.065100	7.42e-01	3.83e-01
Signaling by TGF-beta Receptor Complex	92	6.72e-01	7.95e-01	0.06940	5.17e-02	0.046400	3.92e-01	4.42e-01
Deadenylation of mRNA	22	7.48e-01	8.42e-01	0.06900	-6.90e-02	-0.000940	5.75e-01	9.94e-01
Regulation of PTEN mRNA translation	11	7.80e-01	8.65e-01	0.06890	-4.79e-02	0.049500	7.83e-01	7.76e-01
RAS processing	22	7.24e-01	8.25e-01	0.06890	4.81e-03	-0.068700	9.69e-01	5.77e-01
DNA Repair	280	7.21e-02	1.73e-01	0.06790	6.66e-02	0.013600	5.58e-02	6.96e-01
Signal Transduction	2006	2.46e-08	4.67e-07	0.06790	6.68e-02	0.011900	1.21e-06	3.88e-01
NoRC negatively regulates rRNA expression	52	6.19e-01	7.53e-01	0.06790	6.62e-02	0.014800	4.09e-01	8.54e-01
p75NTR recruits signalling complexes	13	9.33e-01	9.56e-01	0.06740	5.88e-02	0.032900	7.13e-01	8.37e-01
Base-Excision Repair, AP Site Formation	22	8.07e-01	8.81e-01	0.06700	-1.14e-02	-0.066000	9.26e-01	5.92e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	81	5.73e-01	7.12e-01	0.06690	-2.37e-02	-0.062600	7.12e-01	3.31e-01
Formation of Incision Complex in GG-NER	43	8.18e-01	8.86e-01	0.06650	-5.59e-02	-0.036100	5.26e-01	6.82e-01
Post-translational protein modification	1183	1.26e-02	4.31e-02	0.06640	4.97e-02	0.044100	4.37e-03	1.14e-02
Signaling by Hedgehog	138	6.45e-02	1.59e-01	0.06630	3.44e-02	-0.056700	4.86e-01	2.51e-01
Regulation of NPAS4 gene expression	12	8.75e-01	9.19e-01	0.06620	-5.07e-03	-0.066000	9.76e-01	6.92e-01
Regulation of TP53 Activity through Phosphorylation	87	2.04e-01	3.69e-01	0.06610	2.53e-02	-0.061100	6.84e-01	3.25e-01
Cellular responses to stimuli	695	3.08e-03	1.28e-02	0.06610	1.47e-02	0.064500	5.10e-01	3.98e-03
Transcriptional regulation by RUNX2	112	2.84e-01	4.44e-01	0.06610	-4.03e-03	-0.066000	9.41e-01	2.28e-01
Formation of RNA Pol II elongation complex	56	3.31e-01	5.01e-01	0.06600	-3.38e-02	0.056700	6.62e-01	4.63e-01
RNA Polymerase II Transcription Elongation	56	3.31e-01	5.01e-01	0.06600	-3.38e-02	0.056700	6.62e-01	4.63e-01
Formation of the Early Elongation Complex	33	6.29e-01	7.60e-01	0.06590	-6.56e-02	0.006860	5.15e-01	9.46e-01
Formation of the HIV-1 Early Elongation Complex	33	6.29e-01	7.60e-01	0.06590	-6.56e-02	0.006860	5.15e-01	9.46e-01
Biological oxidations	135	2.54e-01	4.15e-01	0.06580	-6.53e-02	-0.007990	1.91e-01	8.73e-01
RHOD GTPase cycle	50	5.58e-01	6.98e-01	0.06570	6.57e-02	0.002120	4.22e-01	9.79e-01
Interferon Signaling	165	4.18e-01	5.83e-01	0.06560	5.82e-02	0.030300	1.97e-01	5.02e-01
mRNA Splicing - Major Pathway	202	4.33e-01	5.93e-01	0.06560	5.28e-02	0.039000	1.97e-01	3.41e-01
RHOH GTPase cycle	31	7.47e-01	8.42e-01	0.06550	6.46e-02	0.010900	5.34e-01	9.16e-01
Endosomal Sorting Complex Required For Transport (ESCRT)	30	7.71e-01	8.58e-01	0.06550	-6.40e-02	-0.013900	5.44e-01	8.95e-01
Heme signaling	44	4.73e-01	6.27e-01	0.06510	-6.16e-02	0.021000	4.79e-01	8.09e-01
TRP channels	20	9.25e-01	9.50e-01	0.06410	5.05e-02	0.039500	6.96e-01	7.60e-01
Nucleotide-like (purinergic) receptors	14	8.30e-01	8.93e-01	0.06410	6.73e-03	-0.063700	9.65e-01	6.80e-01
DNA Damage Bypass	45	4.17e-01	5.83e-01	0.06400	4.87e-02	-0.041600	5.72e-01	6.29e-01
TNFR1-induced proapoptotic signaling	25	8.81e-01	9.22e-01	0.06400	2.95e-02	0.056800	7.99e-01	6.23e-01
Maturation of nucleoprotein 9694631	15	9.08e-01	9.40e-01	0.06380	2.18e-02	0.060000	8.84e-01	6.88e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	4.51e-01	6.06e-01	0.06310	-4.35e-02	0.045800	6.26e-01	6.08e-01
HIV Transcription Elongation	42	4.51e-01	6.06e-01	0.06310	-4.35e-02	0.045800	6.26e-01	6.08e-01
Tat-mediated elongation of the HIV-1 transcript	42	4.51e-01	6.06e-01	0.06310	-4.35e-02	0.045800	6.26e-01	6.08e-01
Activation of HOX genes during differentiation	65	7.20e-01	8.22e-01	0.06300	-5.64e-02	-0.028300	4.32e-01	6.94e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	65	7.20e-01	8.22e-01	0.06300	-5.64e-02	-0.028300	4.32e-01	6.94e-01
RHOQ GTPase cycle	57	3.81e-01	5.44e-01	0.06290	5.72e-02	-0.026100	4.55e-01	7.33e-01
Serotonin Neurotransmitter Release Cycle	13	9.23e-01	9.48e-01	0.06250	-5.88e-02	-0.021300	7.14e-01	8.94e-01
Ovarian tumor domain proteases	35	7.91e-01	8.70e-01	0.06220	1.84e-02	0.059400	8.51e-01	5.43e-01
Glutamate Neurotransmitter Release Cycle	20	8.06e-01	8.81e-01	0.06210	6.21e-02	0.000464	6.31e-01	9.97e-01
Voltage gated Potassium channels	19	9.12e-01	9.41e-01	0.06190	-2.81e-02	-0.055200	8.32e-01	6.77e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	28	7.46e-01	8.42e-01	0.06180	1.32e-03	0.061800	9.90e-01	5.72e-01
Acyl chain remodelling of PC	19	7.51e-01	8.44e-01	0.06170	-1.89e-02	0.058700	8.87e-01	6.58e-01
Neuronal System	256	1.90e-02	6.10e-02	0.06140	2.30e-02	-0.056900	5.28e-01	1.18e-01
RNA Polymerase II Transcription	1194	9.18e-05	7.36e-04	0.06130	-6.05e-02	-0.009510	4.87e-04	5.84e-01
Cellular responses to stress	687	4.01e-03	1.61e-02	0.06120	9.42e-03	0.060500	6.76e-01	7.23e-03
Sialic acid metabolism	28	7.63e-01	8.52e-01	0.06120	6.11e-02	0.003810	5.76e-01	9.72e-01
PKMTs methylate histone lysines	42	5.45e-01	6.85e-01	0.06080	-1.80e-02	0.058000	8.40e-01	5.15e-01
RNA Polymerase I Promoter Escape	37	8.46e-01	9.02e-01	0.06060	-2.80e-02	-0.053700	7.68e-01	5.72e-01
Negative epigenetic regulation of rRNA expression	55	5.70e-01	7.10e-01	0.06050	6.05e-02	0.000407	4.38e-01	9.96e-01
Opioid Signalling	78	2.69e-01	4.29e-01	0.06020	3.47e-02	-0.049300	5.96e-01	4.52e-01
Regulation of TP53 Degradation	35	8.50e-01	9.05e-01	0.05990	-5.38e-02	-0.026400	5.82e-01	7.87e-01
Mitotic G2-G2/M phases	184	4.81e-02	1.27e-01	0.05970	3.49e-02	-0.048500	4.15e-01	2.58e-01
AKT phosphorylates targets in the nucleus	10	8.51e-01	9.05e-01	0.05910	-4.96e-02	0.032300	7.86e-01	8.60e-01
Oncogene Induced Senescence	32	7.17e-01	8.22e-01	0.05890	5.89e-02	-0.002500	5.65e-01	9.81e-01
Transcription of the HIV genome	67	4.01e-01	5.66e-01	0.05890	-5.61e-02	0.017800	4.27e-01	8.01e-01
Nucleotide salvage	22	9.16e-01	9.44e-01	0.05860	5.09e-02	0.029000	6.79e-01	8.14e-01
Gene expression (Transcription)	1352	7.38e-05	6.09e-04	0.05850	-5.78e-02	-0.008970	4.24e-04	5.84e-01
Signaling by FGFR2	61	8.28e-01	8.93e-01	0.05840	-3.81e-02	-0.044200	6.07e-01	5.50e-01
Beta-catenin independent WNT signaling	132	1.25e-01	2.61e-01	0.05840	3.36e-02	-0.047700	5.05e-01	3.44e-01
WNT ligand biogenesis and trafficking	15	7.86e-01	8.67e-01	0.05840	4.56e-02	-0.036400	7.60e-01	8.07e-01
Visual phototransduction	55	7.97e-01	8.75e-01	0.05820	5.14e-02	0.027300	5.10e-01	7.26e-01
Signaling by EGFR	44	7.44e-01	8.41e-01	0.05800	-1.27e-02	-0.056600	8.84e-01	5.16e-01
Metabolic disorders of biological oxidation enzymes	22	7.57e-01	8.50e-01	0.05760	-5.56e-02	0.015100	6.52e-01	9.03e-01
Blood group systems biosynthesis	13	8.61e-01	9.10e-01	0.05760	5.68e-02	-0.009680	7.23e-01	9.52e-01
Cytochrome P450 - arranged by substrate type	32	8.04e-01	8.80e-01	0.05750	1.15e-02	0.056300	9.10e-01	5.81e-01
G2/M Transition	182	6.99e-02	1.69e-01	0.05700	2.95e-02	-0.048800	4.94e-01	2.57e-01
Vitamin B5 (pantothenate) metabolism	16	7.81e-01	8.65e-01	0.05690	-3.91e-02	0.041300	7.86e-01	7.75e-01
Metabolism of steroids	118	1.70e-01	3.28e-01	0.05670	-4.50e-02	0.034500	3.99e-01	5.18e-01
Interactions of Vpr with host cellular proteins	37	8.63e-01	9.11e-01	0.05660	5.03e-02	0.026100	5.97e-01	7.84e-01
mRNA Splicing	210	5.51e-01	6.91e-01	0.05650	4.20e-02	0.037800	2.95e-01	3.46e-01
TRAF6 mediated NF-kB activation	22	8.97e-01	9.35e-01	0.05620	5.27e-02	0.019700	6.69e-01	8.73e-01
VxPx cargo-targeting to cilium	17	9.46e-01	9.63e-01	0.05610	-4.65e-02	-0.031200	7.40e-01	8.24e-01
Metabolism of lipids	605	5.72e-04	3.34e-03	0.05580	-5.22e-02	0.019800	2.93e-02	4.08e-01
Acetylcholine Neurotransmitter Release Cycle	11	9.68e-01	9.78e-01	0.05560	3.42e-02	0.043800	8.44e-01	8.01e-01
Host Interactions of HIV factors	124	1.72e-01	3.30e-01	0.05530	3.21e-02	-0.045100	5.37e-01	3.87e-01
Viral Messenger RNA Synthesis	44	8.10e-01	8.82e-01	0.05470	5.15e-02	0.018300	5.55e-01	8.34e-01
RUNX3 regulates NOTCH signaling	14	9.62e-01	9.73e-01	0.05460	-4.17e-02	-0.035200	7.87e-01	8.20e-01
Regulation of TP53 Expression and Degradation	36	8.66e-01	9.11e-01	0.05380	-4.92e-02	-0.021900	6.10e-01	8.20e-01
Defective Intrinsic Pathway for Apoptosis	21	9.48e-01	9.64e-01	0.05330	3.74e-02	0.038000	7.67e-01	7.63e-01
Spry regulation of FGF signaling	16	9.43e-01	9.62e-01	0.05270	-4.77e-02	-0.022500	7.41e-01	8.76e-01
CD209 (DC-SIGN) signaling	20	8.00e-01	8.78e-01	0.05220	-1.80e-02	0.049000	8.89e-01	7.05e-01
Signaling by FGFR	70	8.44e-01	9.02e-01	0.05190	-3.48e-02	-0.038600	6.15e-01	5.77e-01
Glucagon signaling in metabolic regulation	25	7.30e-01	8.30e-01	0.05190	3.08e-02	-0.041700	7.90e-01	7.18e-01
Dopamine Neurotransmitter Release Cycle	18	8.71e-01	9.16e-01	0.05120	-5.12e-02	0.001160	7.07e-01	9.93e-01
Metabolism of RNA	695	1.78e-01	3.38e-01	0.05020	2.82e-02	0.041600	2.08e-01	6.32e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	18	9.47e-01	9.63e-01	0.05020	2.39e-02	0.044100	8.61e-01	7.46e-01
Neurodegenerative Diseases	18	9.47e-01	9.63e-01	0.05020	2.39e-02	0.044100	8.61e-01	7.46e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	37	7.84e-01	8.66e-01	0.04970	4.96e-02	0.002030	6.01e-01	9.83e-01
RND1 GTPase cycle	36	6.58e-01	7.84e-01	0.04960	3.17e-02	-0.038200	7.42e-01	6.92e-01
ESR-mediated signaling	150	2.51e-01	4.13e-01	0.04950	1.28e-02	-0.047800	7.88e-01	3.13e-01
RNA Polymerase II Pre-transcription Events	77	4.42e-01	5.99e-01	0.04930	-4.41e-02	0.022000	5.04e-01	7.38e-01
Disorders of transmembrane transporters	136	6.14e-01	7.48e-01	0.04900	-1.79e-02	-0.045600	7.19e-01	3.60e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	9.09e-01	9.40e-01	0.04890	4.77e-02	0.010600	7.12e-01	9.35e-01
Developmental Biology	784	4.77e-02	1.26e-01	0.04870	4.64e-02	0.014600	2.81e-02	4.91e-01
HCMV Late Events	59	6.10e-01	7.44e-01	0.04810	-4.71e-02	0.010100	5.32e-01	8.93e-01
Deadenylation-dependent mRNA decay	50	8.93e-01	9.33e-01	0.04800	-3.88e-02	-0.028300	6.35e-01	7.30e-01
CTLA4 inhibitory signaling	18	9.11e-01	9.40e-01	0.04790	6.97e-03	0.047400	9.59e-01	7.28e-01
Inwardly rectifying K+ channels	23	8.29e-01	8.93e-01	0.04780	4.69e-02	-0.009340	6.97e-01	9.38e-01
Defective pyroptosis	19	8.52e-01	9.06e-01	0.04770	4.64e-02	-0.011100	7.26e-01	9.34e-01
Notch-HLH transcription pathway	28	9.38e-01	9.59e-01	0.04750	-3.92e-02	-0.026900	7.20e-01	8.05e-01
RHOV GTPase cycle	34	8.23e-01	8.90e-01	0.04720	-3.12e-03	-0.047100	9.75e-01	6.35e-01
Epigenetic regulation of gene expression	132	5.72e-01	7.12e-01	0.04710	1.14e-02	0.045700	8.22e-01	3.65e-01
RMTs methylate histone arginines	33	7.88e-01	8.69e-01	0.04680	-4.64e-02	0.005870	6.45e-01	9.53e-01
Signaling by Nuclear Receptors	210	6.60e-01	7.84e-01	0.04660	-3.59e-02	-0.029700	3.71e-01	4.58e-01
Ion channel transport	134	3.69e-01	5.36e-01	0.04630	8.09e-03	-0.045600	8.72e-01	3.63e-01
TAK1-dependent IKK and NF-kappa-B activation	42	8.58e-01	9.08e-01	0.04630	4.41e-02	0.014100	6.21e-01	8.75e-01
Signaling by NTRK2 (TRKB)	22	8.44e-01	9.02e-01	0.04580	4.46e-02	-0.010400	7.17e-01	9.33e-01
Synthesis of IP3 and IP4 in the cytosol	22	8.28e-01	8.93e-01	0.04570	4.27e-02	-0.016300	7.29e-01	8.95e-01
Transcriptional Regulation by TP53	340	2.00e-01	3.66e-01	0.04520	-4.49e-02	-0.005490	1.56e-01	8.62e-01
FGFR2 alternative splicing	24	9.45e-01	9.63e-01	0.04520	2.25e-02	0.039100	8.49e-01	7.40e-01
Processing of Intronless Pre-mRNAs	20	8.27e-01	8.93e-01	0.04470	-3.33e-02	0.029800	7.96e-01	8.18e-01
RNA Polymerase I Transcription Initiation	47	7.61e-01	8.52e-01	0.04470	-9.54e-04	0.044700	9.91e-01	5.96e-01
Transcriptional regulation of granulopoiesis	33	9.35e-01	9.57e-01	0.04390	2.37e-02	0.036900	8.13e-01	7.14e-01
Signaling by FGFR in disease	53	9.16e-01	9.44e-01	0.04280	-2.83e-02	-0.032100	7.22e-01	6.86e-01
Signaling by FGFR1 in disease	32	9.09e-01	9.40e-01	0.04240	-4.02e-02	-0.013600	6.94e-01	8.94e-01
Nephrin family interactions	19	8.54e-01	9.07e-01	0.04210	3.36e-02	-0.025400	8.00e-01	8.48e-01
Neurotransmitter release cycle	35	8.25e-01	8.92e-01	0.04210	3.03e-03	-0.041900	9.75e-01	6.68e-01
Dual incision in TC-NER	65	6.33e-01	7.64e-01	0.04200	3.98e-02	-0.013400	5.79e-01	8.52e-01
Purine salvage	13	9.00e-01	9.36e-01	0.04170	3.44e-02	-0.023600	8.30e-01	8.83e-01
tRNA processing in the nucleus	59	8.94e-01	9.33e-01	0.04100	2.08e-02	0.035400	7.83e-01	6.39e-01
Signaling by ERBB2	47	7.11e-01	8.20e-01	0.04050	1.87e-02	-0.036000	8.24e-01	6.70e-01
Metabolism of proteins	1620	9.14e-02	2.09e-01	0.04050	2.33e-02	0.033100	1.23e-01	2.88e-02
B-WICH complex positively regulates rRNA expression	37	9.44e-01	9.63e-01	0.03990	3.23e-02	0.023400	7.34e-01	8.05e-01
Metabolism of non-coding RNA	53	8.96e-01	9.34e-01	0.03930	3.57e-02	0.016600	6.54e-01	8.35e-01
snRNP Assembly	53	8.96e-01	9.34e-01	0.03930	3.57e-02	0.016600	6.54e-01	8.35e-01
Regulation of NF-kappa B signaling	18	9.73e-01	9.82e-01	0.03900	-3.17e-02	-0.022700	8.16e-01	8.67e-01
Regulation of TP53 Activity	151	7.68e-01	8.57e-01	0.03870	-1.89e-02	-0.033800	6.89e-01	4.74e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	9.08e-01	9.40e-01	0.03850	-1.66e-02	0.034700	9.11e-01	8.16e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	6.80e-01	8.01e-01	0.03840	3.60e-02	-0.013500	6.19e-01	8.52e-01
MicroRNA (miRNA) biogenesis	25	9.61e-01	9.73e-01	0.03810	-2.00e-02	-0.032400	8.63e-01	7.79e-01
Assembly and cell surface presentation of NMDA receptors	30	8.58e-01	9.08e-01	0.03810	7.03e-03	-0.037400	9.47e-01	7.23e-01
Organelle biogenesis and maintenance	270	6.50e-01	7.78e-01	0.03780	3.26e-02	0.019100	3.58e-01	5.90e-01
The phototransduction cascade	19	9.76e-01	9.83e-01	0.03740	2.90e-02	0.023600	8.27e-01	8.59e-01
Vpr-mediated nuclear import of PICs	34	9.56e-01	9.69e-01	0.03680	2.97e-02	0.021700	7.64e-01	8.27e-01
Phase II - Conjugation of compounds	66	9.01e-01	9.36e-01	0.03540	1.60e-02	0.031500	8.23e-01	6.58e-01
Negative regulation of the PI3K/AKT network	88	8.13e-01	8.82e-01	0.03530	-8.74e-03	-0.034200	8.87e-01	5.80e-01
Cellular Senescence	129	8.38e-01	8.97e-01	0.03390	1.62e-02	0.029800	7.51e-01	5.59e-01
RNA Polymerase I Transcription Termination	30	9.01e-01	9.36e-01	0.03380	3.38e-02	-0.001910	7.49e-01	9.86e-01
Glutamate and glutamine metabolism	11	9.89e-01	9.91e-01	0.03320	2.61e-02	0.020400	8.81e-01	9.07e-01
FGFR1 mutant receptor activation	25	8.94e-01	9.33e-01	0.03230	-2.93e-02	0.013600	8.00e-01	9.07e-01
Negative regulators of DDX58/IFIH1 signaling	34	8.80e-01	9.22e-01	0.03200	-3.12e-02	0.007210	7.53e-01	9.42e-01
Stimuli-sensing channels	75	9.09e-01	9.40e-01	0.03120	-1.36e-02	-0.028100	8.39e-01	6.74e-01
HIV Life Cycle	145	7.06e-01	8.17e-01	0.03020	1.43e-03	0.030200	9.76e-01	5.31e-01
Late Phase of HIV Life Cycle	132	6.38e-01	7.69e-01	0.03020	-7.43e-03	0.029300	8.83e-01	5.62e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	9.38e-01	9.59e-01	0.02990	-1.93e-02	-0.022900	7.68e-01	7.27e-01
tRNA processing	109	8.65e-01	9.11e-01	0.02920	2.74e-02	0.010200	6.21e-01	8.55e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	25	9.83e-01	9.87e-01	0.02750	-2.03e-02	-0.018600	8.61e-01	8.72e-01
Trafficking of AMPA receptors	25	9.83e-01	9.87e-01	0.02750	-2.03e-02	-0.018600	8.61e-01	8.72e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	65	8.07e-01	8.81e-01	0.02720	-2.40e-02	0.013000	7.38e-01	8.57e-01
Inactivation, recovery and regulation of the phototransduction cascade	18	9.52e-01	9.66e-01	0.02590	9.12e-03	-0.024200	9.47e-01	8.59e-01
Toll Like Receptor 4 (TLR4) Cascade	134	6.98e-01	8.12e-01	0.02510	1.04e-02	-0.022800	8.35e-01	6.49e-01
Uptake and actions of bacterial toxins	24	9.62e-01	9.73e-01	0.02460	1.16e-03	0.024600	9.92e-01	8.35e-01
Transcriptional regulation by small RNAs	53	9.07e-01	9.40e-01	0.02420	2.42e-02	-0.002060	7.61e-01	9.79e-01
Signaling by TGFB family members	115	7.49e-01	8.42e-01	0.02320	1.81e-02	-0.014400	7.37e-01	7.90e-01
NOD1/2 Signaling Pathway	36	9.31e-01	9.55e-01	0.02270	6.25e-03	-0.021800	9.48e-01	8.21e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	51	9.37e-01	9.59e-01	0.02230	-2.22e-02	-0.001580	7.84e-01	9.84e-01
Signaling by KIT in disease	19	9.74e-01	9.82e-01	0.02210	-1.99e-04	0.022100	9.99e-01	8.67e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	19	9.74e-01	9.82e-01	0.02210	-1.99e-04	0.022100	9.99e-01	8.67e-01
Signaling by Insulin receptor	64	9.30e-01	9.54e-01	0.01850	1.84e-02	-0.002270	7.99e-01	9.75e-01
NS1 Mediated Effects on Host Pathways	40	9.54e-01	9.67e-01	0.01840	1.81e-02	-0.003170	8.43e-01	9.72e-01
HIV Infection	220	7.73e-01	8.60e-01	0.01830	3.32e-03	-0.018000	9.32e-01	6.45e-01
Aggrephagy	32	9.81e-01	9.87e-01	0.01690	-3.12e-03	-0.016600	9.76e-01	8.71e-01
Gene Silencing by RNA	78	9.50e-01	9.64e-01	0.01470	1.47e-02	-0.000906	8.23e-01	9.89e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	9.23e-01	9.48e-01	0.01430	8.56e-03	-0.011500	8.92e-01	8.56e-01
RNA Polymerase I Promoter Clearance	56	9.87e-01	9.89e-01	0.01410	6.68e-03	0.012400	9.31e-01	8.73e-01
RNA Polymerase I Transcription	56	9.87e-01	9.89e-01	0.01410	6.68e-03	0.012400	9.31e-01	8.73e-01
Transport of small molecules	533	7.07e-01	8.18e-01	0.01230	1.10e-02	-0.005630	6.66e-01	8.25e-01
Pre-NOTCH Transcription and Translation	39	9.95e-01	9.95e-01	0.01150	9.59e-03	0.006360	9.18e-01	9.45e-01
PIWI-interacting RNA (piRNA) biogenesis	21	9.90e-01	9.91e-01	0.01010	7.66e-03	-0.006580	9.52e-01	9.58e-01
Cyclin D associated events in G1	45	9.82e-01	9.87e-01	0.00949	-8.44e-03	0.004340	9.22e-01	9.60e-01
G1 Phase	45	9.82e-01	9.87e-01	0.00949	-8.44e-03	0.004340	9.22e-01	9.60e-01
Nucleotide Excision Repair	110	9.98e-01	9.98e-01	0.00386	1.63e-03	0.003500	9.76e-01	9.49e-01

---

Detailed Gene set reports

Zinc transporters

Zinc transporters

metric	value
setSize	10
pMANOVA	0.000151
p.adjustMANOVA	0.00113
s.dist	0.993
s.intact	0.685
s.torn	0.719
p.intact	0.000177
p.torn	8.15e-05

Top 20 genes

Gene	intact	torn
SLC39A6	6764	7432
SLC39A7	6678	7084
SLC39A14	6307	6869
SLC39A1	5985	5105
SLC39A10	4337	5270
SLC30A1	5629	4011
SLC39A3	5377	4033
SLC39A8	2437	6671
SLC30A5	5169	3140
SLC39A4	1142	5561

Click HERE to show all gene set members

All member genes

	intact	torn
SLC30A1	5629	4011
SLC30A5	5169	3140
SLC39A1	5985	5105
SLC39A10	4337	5270
SLC39A14	6307	6869
SLC39A3	5377	4033
SLC39A4	1142	5561
SLC39A6	6764	7432
SLC39A7	6678	7084
SLC39A8	2437	6671

---

---

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

metric	value
setSize	10
pMANOVA	0.000173
p.adjustMANOVA	0.00126
s.dist	0.987
s.intact	-0.703
s.torn	-0.692
p.intact	0.000117
p.torn	0.000151

Top 20 genes

Gene	intact	torn
MAPK12	-8529	-7799
PRKAA2	-8538	-6729
PRKAB2	-7549	-7003
PRKAG3	-8396	-6178
PPARGC1A	-8503	-5926
PRKAB1	-4595	-7208
MAPK11	-3482	-8220
PRKAG1	-5379	-4813
MAPK14	-7268	-3304
PRKAG2	-150	-1745

Click HERE to show all gene set members

All member genes

	intact	torn
MAPK11	-3482	-8220
MAPK12	-8529	-7799
MAPK14	-7268	-3304
PPARGC1A	-8503	-5926
PRKAA2	-8538	-6729
PRKAB1	-4595	-7208
PRKAB2	-7549	-7003
PRKAG1	-5379	-4813
PRKAG2	-150	-1745
PRKAG3	-8396	-6178

---

---

Citric acid cycle (TCA cycle)

Citric acid cycle (TCA cycle)

metric	value
setSize	22
pMANOVA	3.21e-09
p.adjustMANOVA	7.33e-08
s.dist	0.967
s.intact	-0.764
s.torn	-0.593
p.intact	5.42e-10
p.torn	1.47e-06

Top 20 genes

Gene	intact	torn
MDH2	-8040	-6807
IDH2	-8356	-6545
SUCLA2	-8071	-6730
ACO2	-8205	-6231
NNT	-8153	-6224
CS	-8054	-6269
SDHA	-7968	-6259
SDHD	-7840	-6271
OGDH	-6983	-6864
FH	-7570	-5774
SUCLG2	-7110	-6011
DLD	-7856	-5437
SDHB	-7660	-5567
IDH3B	-6689	-6085
SUCLG1	-6871	-5445
IDH3A	-7007	-5285
DLST	-6374	-4355
SDHC	-5841	-3721
FAHD1	-3561	-3101
ME2	-5287	-2017

Click HERE to show all gene set members

All member genes

	intact	torn
ACO2	-8205	-6231
CS	-8054	-6269
DLD	-7856	-5437
DLST	-6374	-4355
FAHD1	-3561	-3101
FH	-7570	-5774
IDH2	-8356	-6545
IDH3A	-7007	-5285
IDH3B	-6689	-6085
IDH3G	-4015	157
MDH2	-8040	-6807
ME2	-5287	-2017
ME3	-457	-1092
NNT	-8153	-6224
OGDH	-6983	-6864
SDHA	-7968	-6259
SDHB	-7660	-5567
SDHC	-5841	-3721
SDHD	-7840	-6271
SUCLA2	-8071	-6730
SUCLG1	-6871	-5445
SUCLG2	-7110	-6011

---

---

mitochondrial fatty acid beta-oxidation of saturated fatty acids

mitochondrial fatty acid beta-oxidation of saturated fatty acids

metric	value
setSize	10
pMANOVA	5.72e-05
p.adjustMANOVA	0.000518
s.dist	0.945
s.intact	-0.804
s.torn	-0.497
p.intact	1.08e-05
p.torn	0.00654

Top 20 genes

Gene	intact	torn
ACADL	-8128	-5962
HADH	-8425	-5609
ACADM	-8237	-5454
HADHB	-7983	-4705
MECR	-7061	-4984
ACADS	-8083	-3826
ECHS1	-7315	-4209
HADHA	-6658	-3135
ACADVL	-7115	-1549
ACSM3	-1495	-3700

Click HERE to show all gene set members

All member genes

	intact	torn
ACADL	-8128	-5962
ACADM	-8237	-5454
ACADS	-8083	-3826
ACADVL	-7115	-1549
ACSM3	-1495	-3700
ECHS1	-7315	-4209
HADH	-8425	-5609
HADHA	-6658	-3135
HADHB	-7983	-4705
MECR	-7061	-4984

---

---

Glyoxylate metabolism and glycine degradation

Glyoxylate metabolism and glycine degradation

metric	value
setSize	23
pMANOVA	1.86e-09
p.adjustMANOVA	4.61e-08
s.dist	0.929
s.intact	-0.763
s.torn	-0.529
p.intact	2.29e-10
p.torn	1.12e-05

Top 20 genes

Gene	intact	torn
PDHX	-8084	-6771
ALDH4A1	-8115	-6742
GOT2	-8232	-6188
DLAT	-7750	-6218
PDHB	-7226	-6667
OGDH	-6983	-6864
NDUFAB1	-7245	-6596
GCSH	-6744	-6838
DLD	-7856	-5437
LIAS	-6602	-6169
DHTKD1	-6773	-5188
PDHA1	-7678	-4488
LIPT2	-6213	-5496
PXMP2	-7441	-4165
DBT	-7055	-4219
DLST	-6374	-4355
HOGA1	-5473	-4564
GRHPR	-5925	-4036
BCKDHA	-6282	-2742
BCKDHB	-6549	-1877

Click HERE to show all gene set members

All member genes

	intact	torn
ALDH4A1	-8115	-6742
AMT	-4160	1079
BCKDHA	-6282	-2742
BCKDHB	-6549	-1877
DBT	-7055	-4219
DDO	-6698	553
DHTKD1	-6773	-5188
DLAT	-7750	-6218
DLD	-7856	-5437
DLST	-6374	-4355
GCSH	-6744	-6838
GOT2	-8232	-6188
GRHPR	-5925	-4036
HOGA1	-5473	-4564
LIAS	-6602	-6169
LIPT1	-3099	-1153
LIPT2	-6213	-5496
NDUFAB1	-7245	-6596
OGDH	-6983	-6864
PDHA1	-7678	-4488
PDHB	-7226	-6667
PDHX	-8084	-6771
PXMP2	-7441	-4165

---

---

Mucopolysaccharidoses

Mucopolysaccharidoses

metric	value
setSize	11
pMANOVA	0.000399
p.adjustMANOVA	0.00249
s.dist	0.884
s.intact	0.669
s.torn	0.579
p.intact	0.000123
p.torn	0.000884

Top 20 genes

Gene	intact	torn
IDS	7375	6668
GUSB	6730	5553
GALNS	4907	6180
HGSNAT	5381	5456
NAGLU	5130	5572
ARSB	6069	3374
GLB1	4776	4287
IDUA	3671	5340
GNS	3778	3027
SGSH	3036	2233
HYAL1	2512	508

Click HERE to show all gene set members

All member genes

	intact	torn
ARSB	6069	3374
GALNS	4907	6180
GLB1	4776	4287
GNS	3778	3027
GUSB	6730	5553
HGSNAT	5381	5456
HYAL1	2512	508
IDS	7375	6668
IDUA	3671	5340
NAGLU	5130	5572
SGSH	3036	2233

---

---

Dissolution of Fibrin Clot

Dissolution of Fibrin Clot

metric	value
setSize	10
pMANOVA	0.00116
p.adjustMANOVA	0.00579
s.dist	0.851
s.intact	0.663
s.torn	0.533
p.intact	0.000285
p.torn	0.0035

Top 20 genes

Gene	intact	torn
PLAUR	7364	7362
S100A10	7464	6752
ANXA2	7167	6912
SERPINE1	6648	7379
SERPINB8	6306	6341
PLAU	5798	5590
SERPINE2	5441	3435
SERPINB6	4884	3690

Click HERE to show all gene set members

All member genes

	intact	torn
ANXA2	7167	6912
PLAT	-2706	-7797
PLAU	5798	5590
PLAUR	7364	7362
S100A10	7464	6752
SERPINB6	4884	3690
SERPINB8	6306	6341
SERPINE1	6648	7379
SERPINE2	5441	3435
SERPINF2	-333	461

---

---

Complex I biogenesis

Complex I biogenesis

metric	value
setSize	51
pMANOVA	7.55e-16
p.adjustMANOVA	9.18e-14
s.dist	0.847
s.intact	-0.67
s.torn	-0.519
p.intact	1.19e-16
p.torn	1.47e-10

Top 20 genes

Gene	intact	torn
NDUFB9	-7822	-7452
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFV2	-7314	-7463
NDUFA9	-7515	-7107
NDUFA5	-7754	-6774
NDUFS1	-7954	-6335
NDUFA7	-7879	-6365
NDUFAB1	-7245	-6596
NDUFB5	-7388	-6144
NDUFS2	-7745	-5848
NDUFS3	-6714	-6623
NDUFB10	-7339	-6056
NDUFC1	-7815	-5629
NDUFS7	-7676	-5397
NDUFA12	-6652	-6147
NDUFAF4	-6389	-6062
TIMMDC1	-6896	-5549
ECSIT	-7163	-5276
NDUFA8	-6589	-5706

Click HERE to show all gene set members

All member genes

	intact	torn
ACAD9	-4363	2633
COA1	-6890	-4487
ECSIT	-7163	-5276
NDUFA1	-5013	-1869
NDUFA10	-7180	-4623
NDUFA11	-1729	776
NDUFA12	-6652	-6147
NDUFA13	-4109	-801
NDUFA2	-5561	-4159
NDUFA3	-6815	-723
NDUFA5	-7754	-6774
NDUFA6	-5687	-4405
NDUFA7	-7879	-6365
NDUFA8	-6589	-5706
NDUFA9	-7515	-7107
NDUFAB1	-7245	-6596
NDUFAF1	-5412	-4937
NDUFAF2	-832	-4080
NDUFAF3	-4296	-990
NDUFAF4	-6389	-6062
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFAF7	-5208	321
NDUFB1	-5491	-5142
NDUFB10	-7339	-6056
NDUFB11	-6743	-4383
NDUFB2	-4947	-3728
NDUFB3	-6572	-4668
NDUFB4	-6614	-4484
NDUFB5	-7388	-6144
NDUFB6	-6086	-5073
NDUFB7	-5631	-4943
NDUFB8	-6139	-4450
NDUFB9	-7822	-7452
NDUFC1	-7815	-5629
NDUFC2	-6395	-5146
NDUFS1	-7954	-6335
NDUFS2	-7745	-5848
NDUFS3	-6714	-6623
NDUFS4	-6430	-5416
NDUFS5	-1940	-2121
NDUFS6	-4518	-3789
NDUFS7	-7676	-5397
NDUFS8	-5843	-5321
NDUFV1	-7265	-4505
NDUFV2	-7314	-7463
NDUFV3	-7003	-4239
NUBPL	-2636	-748
TIMMDC1	-6896	-5549
TMEM126B	528	-2289
TMEM186	-4089	-3251

---

---

FCGR activation

FCGR activation

metric	value
setSize	10
pMANOVA	0.00156
p.adjustMANOVA	0.00727
s.dist	0.843
s.intact	0.551
s.torn	0.638
p.intact	0.00256
p.torn	0.00048

Top 20 genes

Gene	intact	torn
SRC	6846	6867
SYK	5282	7144
FGR	5336	5356
HCK	4480	5657
FCGR1A	3416	7413
LYN	4448	5169
FCGR2A	2559	7520
FCGR3A	2148	2343
FYN	2870	1392

Click HERE to show all gene set members

All member genes

	intact	torn
FCGR1A	3416	7413
FCGR2A	2559	7520
FCGR3A	2148	2343
FGR	5336	5356
FYN	2870	1392
HCK	4480	5657
LYN	4448	5169
SRC	6846	6867
SYK	5282	7144
YES1	1603	-299

---

---

Trafficking and processing of endosomal TLR

Trafficking and processing of endosomal TLR

metric	value
setSize	12
pMANOVA	0.000473
p.adjustMANOVA	0.00284
s.dist	0.829
s.intact	0.525
s.torn	0.642
p.intact	0.00165
p.torn	0.000118

Top 20 genes

Gene	intact	torn
HSP90B1	6958	7162
UNC93B1	6062	6439
CNPY3	6072	6068
TLR8	4281	7261
CTSB	5312	5823
CTSK	6499	3803
CTSS	4626	5172
TLR7	4178	4478
LGMN	3074	3791
CTSL	3473	3054

Click HERE to show all gene set members

All member genes

	intact	torn
CNPY3	6072	6068
CTSB	5312	5823
CTSK	6499	3803
CTSL	3473	3054
CTSS	4626	5172
HSP90B1	6958	7162
LGMN	3074	3791
TLR3	-108	-321
TLR7	4178	4478
TLR8	4281	7261
TLR9	-6182	5953
UNC93B1	6062	6439

---

---

CS/DS degradation

CS/DS degradation

metric	value
setSize	10
pMANOVA	0.0024
p.adjustMANOVA	0.0102
s.dist	0.811
s.intact	0.621
s.torn	0.521
p.intact	0.000678
p.torn	0.0043

Top 20 genes

Gene	intact	torn
IDS	7375	6668
HEXB	6712	6347
BGN	3996	7647
HEXA	4558	4640
ARSB	6069	3374
IDUA	3671	5340
CSPG4	7124	2593
VCAN	3440	389
HYAL1	2512	508

Click HERE to show all gene set members

All member genes

	intact	torn
ARSB	6069	3374
BGN	3996	7647
CSPG4	7124	2593
DCN	-825	1664
HEXA	4558	4640
HEXB	6712	6347
HYAL1	2512	508
IDS	7375	6668
IDUA	3671	5340
VCAN	3440	389

---

---

Expression and translocation of olfactory receptors

Expression and translocation of olfactory receptors

metric	value
setSize	21
pMANOVA	7.22e-11
p.adjustMANOVA	2.57e-09
s.dist	0.806
s.intact	-0.245
s.torn	-0.769
p.intact	0.0524
p.torn	1.07e-09

Top 20 genes

Gene	intact	torn
REEP1	-7892	-7869
OR56A1	-4598	-8150
OR7C1	-3963	-7836
OR1D2	-3276	-8377
OR6Y1	-3454	-7927
OR5AN1	-3569	-7562
OR4D9	-3507	-7035
OR10H5	-4593	-4808
OR8A1	-3217	-6765
OR10G3	-2034	-8266
OR2AT4	-1806	-8172
OR5A2	-2543	-5585
OR5A1	-1748	-7864
OR2M3	-1672	-8155
OR6C75	-1291	-7862
OR5AS1	-1059	-6136
OR14J1	-984	-6531
OR52K1	-449	-6832

Click HERE to show all gene set members

All member genes

	intact	torn
EBF1	2056	-4233
LDB1	-4293	4017
OR10G3	-2034	-8266
OR10H5	-4593	-4808
OR14J1	-984	-6531
OR1D2	-3276	-8377
OR1I1	788	-4700
OR2AT4	-1806	-8172
OR2M3	-1672	-8155
OR4D9	-3507	-7035
OR52K1	-449	-6832
OR56A1	-4598	-8150
OR5A1	-1748	-7864
OR5A2	-2543	-5585
OR5AN1	-3569	-7562
OR5AS1	-1059	-6136
OR6C75	-1291	-7862
OR6Y1	-3454	-7927
OR7C1	-3963	-7836
OR8A1	-3217	-6765
REEP1	-7892	-7869

---

---

Respiratory electron transport

Respiratory electron transport

metric	value
setSize	93
pMANOVA	1.09e-25
p.adjustMANOVA	5.29e-23
s.dist	0.804
s.intact	-0.639
s.torn	-0.487
p.intact	1.51e-26
p.torn	4.64e-16

Top 20 genes

Gene	intact	torn
CYCS	-7755	-7529
NDUFB9	-7822	-7452
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFV2	-7314	-7463
COX5A	-7987	-6689
NDUFA9	-7515	-7107
UQCRFS1	-7919	-6737
NDUFA4	-7637	-6902
NDUFA5	-7754	-6774
UQCR10	-8129	-6389
COQ10A	-8394	-6036
CYC1	-7872	-6421
NDUFS1	-7954	-6335
NDUFA7	-7879	-6365
SDHA	-7968	-6259
SDHD	-7840	-6271
COX11	-7301	-6625
UQCRC2	-7798	-6175
NDUFAB1	-7245	-6596

Click HERE to show all gene set members

All member genes

	intact	torn
ACAD9	-4363	2633
COA1	-6890	-4487
COQ10A	-8394	-6036
COQ10B	7001	-999
COX11	-7301	-6625
COX14	-6818	-5406
COX16	-3655	-3865
COX18	-4551	-1129
COX19	-3458	3794
COX20	2583	-1535
COX4I1	-5679	-4299
COX5A	-7987	-6689
COX5B	-7229	-5236
COX6A1	6200	6571
COX6B1	-5976	-2832
COX6C	-6492	-6157
COX7A2L	-279	1790
COX7B	-7145	-5876
COX7C	-6809	-5090
COX8A	-6998	-6119
CYC1	-7872	-6421
CYCS	-7755	-7529
ECSIT	-7163	-5276
ETFA	-7398	-5414
ETFB	-6397	-3147
ETFDH	-8136	-2651
LRPPRC	-7250	-4398
NDUFA1	-5013	-1869
NDUFA10	-7180	-4623
NDUFA11	-1729	776
NDUFA12	-6652	-6147
NDUFA13	-4109	-801
NDUFA2	-5561	-4159
NDUFA3	-6815	-723
NDUFA4	-7637	-6902
NDUFA5	-7754	-6774
NDUFA6	-5687	-4405
NDUFA7	-7879	-6365
NDUFA8	-6589	-5706
NDUFA9	-7515	-7107
NDUFAB1	-7245	-6596
NDUFAF1	-5412	-4937
NDUFAF2	-832	-4080
NDUFAF3	-4296	-990
NDUFAF4	-6389	-6062
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFAF7	-5208	321
NDUFB1	-5491	-5142
NDUFB10	-7339	-6056
NDUFB11	-6743	-4383
NDUFB2	-4947	-3728
NDUFB3	-6572	-4668
NDUFB4	-6614	-4484
NDUFB5	-7388	-6144
NDUFB6	-6086	-5073
NDUFB7	-5631	-4943
NDUFB8	-6139	-4450
NDUFB9	-7822	-7452
NDUFC1	-7815	-5629
NDUFC2	-6395	-5146
NDUFS1	-7954	-6335
NDUFS2	-7745	-5848
NDUFS3	-6714	-6623
NDUFS4	-6430	-5416
NDUFS5	-1940	-2121
NDUFS6	-4518	-3789
NDUFS7	-7676	-5397
NDUFS8	-5843	-5321
NDUFV1	-7265	-4505
NDUFV2	-7314	-7463
NDUFV3	-7003	-4239
NUBPL	-2636	-748
SCO1	-3739	-2555
SCO2	7338	7271
SDHA	-7968	-6259
SDHB	-7660	-5567
SDHC	-5841	-3721
SDHD	-7840	-6271
SURF1	-4531	-314
TACO1	-6537	-5659
TIMMDC1	-6896	-5549
TMEM126B	528	-2289
TMEM186	-4089	-3251
TRAP1	-7397	-5335
UQCR10	-8129	-6389
UQCR11	-6849	-4922
UQCRB	-7093	-5183
UQCRC1	-7215	-5719
UQCRC2	-7798	-6175
UQCRFS1	-7919	-6737
UQCRH	-4855	-3291
UQCRQ	-6252	-4582

---

---

Diseases associated with N-glycosylation of proteins

Diseases associated with N-glycosylation of proteins

metric	value
setSize	20
pMANOVA	5.02e-06
p.adjustMANOVA	6.78e-05
s.dist	0.802
s.intact	0.633
s.torn	0.494
p.intact	9.63e-07
p.torn	0.000132

Top 20 genes

Gene	intact	torn
MAN1B1	6700	6673
B4GALT1	5635	7394
ALG2	7024	5700
MPDU1	6702	4911
MGAT2	6205	5243
MOGS	4762	5949
RFT1	4449	5795
GLB1	4776	4287
CTSA	3700	5096
ALG11	3989	4480
ALG3	4184	4185
ALG12	3094	5411
DPAGT1	3391	4184
ALG13	3759	3375
NEU1	3479	2941
ALG8	6335	1614
ALG1	4955	1555
ALG9	4080	92

Click HERE to show all gene set members

All member genes

	intact	torn
ALG1	4955	1555
ALG11	3989	4480
ALG12	3094	5411
ALG13	3759	3375
ALG14	4822	-1716
ALG2	7024	5700
ALG3	4184	4185
ALG6	-883	-3371
ALG8	6335	1614
ALG9	4080	92
B4GALT1	5635	7394
CTSA	3700	5096
DPAGT1	3391	4184
GLB1	4776	4287
MAN1B1	6700	6673
MGAT2	6205	5243
MOGS	4762	5949
MPDU1	6702	4911
NEU1	3479	2941
RFT1	4449	5795

---

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

metric	value
setSize	16
pMANOVA	6.09e-05
p.adjustMANOVA	0.000536
s.dist	0.801
s.intact	-0.63
s.torn	-0.495
p.intact	1.27e-05
p.torn	0.000614

Top 20 genes

Gene	intact	torn
ATP5F1B	-7536	-6631
ATP5F1A	-7645	-6364
ATP5F1D	-7469	-6181
ATP5PF	-7131	-6008
ATP5MC1	-7605	-5456
ATP5MC2	-7267	-5344
ATP5MC3	-6992	-5469
ATP5F1C	-5966	-6191
ATP5PO	-7127	-5151
DMAC2L	-6386	-5479
ATP5PB	-6063	-5439
ATP5MG	-4982	-3152
ATP5PD	-5149	-2955
ATP5MF	-2922	-1373

Click HERE to show all gene set members

All member genes

	intact	torn
ATP5F1A	-7645	-6364
ATP5F1B	-7536	-6631
ATP5F1C	-5966	-6191
ATP5F1D	-7469	-6181
ATP5F1E	2008	1067
ATP5MC1	-7605	-5456
ATP5MC2	-7267	-5344
ATP5MC3	-6992	-5469
ATP5ME	-2122	1401
ATP5MF	-2922	-1373
ATP5MG	-4982	-3152
ATP5PB	-6063	-5439
ATP5PD	-5149	-2955
ATP5PF	-7131	-6008
ATP5PO	-7127	-5151
DMAC2L	-6386	-5479

---

---

Keratan sulfate degradation

Keratan sulfate degradation

metric	value
setSize	13
pMANOVA	0.000434
p.adjustMANOVA	0.00267
s.dist	0.796
s.intact	0.495
s.torn	0.623
p.intact	0.002
p.torn	9.94e-05

Top 20 genes

Gene	intact	torn
OGN	5973	7472
HEXB	6712	6347
LUM	4464	7188
GALNS	4907	6180
GLB1L	4374	5404
FMOD	3229	7148
HEXA	4558	4640
GLB1	4776	4287
OMD	2278	6678
GNS	3778	3027
PRELP	1610	5481
ACAN	724	6147

Click HERE to show all gene set members

All member genes

	intact	torn
ACAN	724	6147
FMOD	3229	7148
GALNS	4907	6180
GLB1	4776	4287
GLB1L	4374	5404
GNS	3778	3027
HEXA	4558	4640
HEXB	6712	6347
KERA	-2561	-8380
LUM	4464	7188
OGN	5973	7472
OMD	2278	6678
PRELP	1610	5481

---

---

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

metric	value
setSize	113
pMANOVA	7.84e-30
p.adjustMANOVA	5.72e-27
s.dist	0.788
s.intact	-0.626
s.torn	-0.479
p.intact	1.21e-30
p.torn	1.29e-18

Top 20 genes

Gene	intact	torn
UCP3	-8572	-6830
CYCS	-7755	-7529
NDUFB9	-7822	-7452
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFV2	-7314	-7463
COX5A	-7987	-6689
NDUFA9	-7515	-7107
UQCRFS1	-7919	-6737
NDUFA4	-7637	-6902
NDUFA5	-7754	-6774
UQCR10	-8129	-6389
COQ10A	-8394	-6036
CYC1	-7872	-6421
NDUFS1	-7954	-6335
NDUFA7	-7879	-6365
ATP5F1B	-7536	-6631
SDHA	-7968	-6259
SDHD	-7840	-6271
ATP5F1A	-7645	-6364

Click HERE to show all gene set members

All member genes

	intact	torn
ACAD9	-4363	2633
ATP5F1A	-7645	-6364
ATP5F1B	-7536	-6631
ATP5F1C	-5966	-6191
ATP5F1D	-7469	-6181
ATP5F1E	2008	1067
ATP5MC1	-7605	-5456
ATP5MC2	-7267	-5344
ATP5MC3	-6992	-5469
ATP5ME	-2122	1401
ATP5MF	-2922	-1373
ATP5MG	-4982	-3152
ATP5PB	-6063	-5439
ATP5PD	-5149	-2955
ATP5PF	-7131	-6008
ATP5PO	-7127	-5151
COA1	-6890	-4487
COQ10A	-8394	-6036
COQ10B	7001	-999
COX11	-7301	-6625
COX14	-6818	-5406
COX16	-3655	-3865
COX18	-4551	-1129
COX19	-3458	3794
COX20	2583	-1535
COX4I1	-5679	-4299
COX5A	-7987	-6689
COX5B	-7229	-5236
COX6A1	6200	6571
COX6B1	-5976	-2832
COX6C	-6492	-6157
COX7A2L	-279	1790
COX7B	-7145	-5876
COX7C	-6809	-5090
COX8A	-6998	-6119
CYC1	-7872	-6421
CYCS	-7755	-7529
DMAC2L	-6386	-5479
ECSIT	-7163	-5276
ETFA	-7398	-5414
ETFB	-6397	-3147
ETFDH	-8136	-2651
LRPPRC	-7250	-4398
NDUFA1	-5013	-1869
NDUFA10	-7180	-4623
NDUFA11	-1729	776
NDUFA12	-6652	-6147
NDUFA13	-4109	-801
NDUFA2	-5561	-4159
NDUFA3	-6815	-723
NDUFA4	-7637	-6902
NDUFA5	-7754	-6774
NDUFA6	-5687	-4405
NDUFA7	-7879	-6365
NDUFA8	-6589	-5706
NDUFA9	-7515	-7107
NDUFAB1	-7245	-6596
NDUFAF1	-5412	-4937
NDUFAF2	-832	-4080
NDUFAF3	-4296	-990
NDUFAF4	-6389	-6062
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFAF7	-5208	321
NDUFB1	-5491	-5142
NDUFB10	-7339	-6056
NDUFB11	-6743	-4383
NDUFB2	-4947	-3728
NDUFB3	-6572	-4668
NDUFB4	-6614	-4484
NDUFB5	-7388	-6144
NDUFB6	-6086	-5073
NDUFB7	-5631	-4943
NDUFB8	-6139	-4450
NDUFB9	-7822	-7452
NDUFC1	-7815	-5629
NDUFC2	-6395	-5146
NDUFS1	-7954	-6335
NDUFS2	-7745	-5848
NDUFS3	-6714	-6623
NDUFS4	-6430	-5416
NDUFS5	-1940	-2121
NDUFS6	-4518	-3789
NDUFS7	-7676	-5397
NDUFS8	-5843	-5321
NDUFV1	-7265	-4505
NDUFV2	-7314	-7463
NDUFV3	-7003	-4239
NUBPL	-2636	-748
SCO1	-3739	-2555
SCO2	7338	7271
SDHA	-7968	-6259
SDHB	-7660	-5567
SDHC	-5841	-3721
SDHD	-7840	-6271
SLC25A14	5338	3092
SLC25A27	-6767	-4643
SURF1	-4531	-314
TACO1	-6537	-5659
TIMMDC1	-6896	-5549
TMEM126B	528	-2289
TMEM186	-4089	-3251
TRAP1	-7397	-5335
UCP2	-829	302
UCP3	-8572	-6830
UQCR10	-8129	-6389
UQCR11	-6849	-4922
UQCRB	-7093	-5183
UQCRC1	-7215	-5719
UQCRC2	-7798	-6175
UQCRFS1	-7919	-6737
UQCRH	-4855	-3291
UQCRQ	-6252	-4582

---

---

The activation of arylsulfatases

The activation of arylsulfatases

metric	value
setSize	10
pMANOVA	0.00381
p.adjustMANOVA	0.0155
s.dist	0.781
s.intact	0.594
s.torn	0.507
p.intact	0.00115
p.torn	0.0055

Top 20 genes

Gene	intact	torn
ARSI	7039	6046
SUMF1	5997	6331
ARSJ	6259	5054
ARSB	6069	3374
ARSD	2944	6385
SUMF2	5487	2807
ARSK	4268	3016
ARSG	3448	2676
ARSA	2095	4105

Click HERE to show all gene set members

All member genes

	intact	torn
ARSA	2095	4105
ARSB	6069	3374
ARSD	2944	6385
ARSG	3448	2676
ARSI	7039	6046
ARSJ	6259	5054
ARSK	4268	3016
STS	-1134	-1796
SUMF1	5997	6331
SUMF2	5487	2807

---

---

Striated Muscle Contraction

Striated Muscle Contraction

metric	value
setSize	34
pMANOVA	1.52e-08
p.adjustMANOVA	2.95e-07
s.dist	0.769
s.intact	-0.565
s.torn	-0.522
p.intact	1.16e-08
p.torn	1.41e-07

Top 20 genes

Gene	intact	torn
TNNI3	-8469	-8308
TPM1	-8365	-8005
TNNT2	-8279	-8018
TPM2	-8523	-7653
DMD	-8463	-7501
MYH6	-8591	-7314
TPM3	-8389	-7363
TMOD1	-8254	-7311
MYH3	-8234	-7249
TNNT3	-8607	-6001
MYBPC1	-6121	-6339
MYL2	-6423	-5726
ACTA1	-5816	-5892
NEB	-8642	-3796
TNNC2	-8209	-3978
MYL1	-5747	-5402
TNNI1	-5532	-5286
MYBPC2	-5408	-5268
TCAP	-5328	-5277
ACTC1	-3193	-8387

Click HERE to show all gene set members

All member genes

	intact	torn
ACTA1	-5816	-5892
ACTC1	-3193	-8387
ACTN2	-4499	-4753
ACTN3	-8638	-2953
DES	-4538	-4251
DMD	-8463	-7501
MYBPC1	-6121	-6339
MYBPC2	-5408	-5268
MYBPC3	-1167	4456
MYH3	-8234	-7249
MYH6	-8591	-7314
MYL1	-5747	-5402
MYL2	-6423	-5726
MYL3	-3625	-4759
NEB	-8642	-3796
TCAP	-5328	-5277
TMOD1	-8254	-7311
TMOD2	1323	-1567
TMOD3	4920	1103
TMOD4	-7386	-3127
TNNC1	-5259	-4184
TNNC2	-8209	-3978
TNNI1	-5532	-5286
TNNI2	-4199	-5647
TNNI3	-8469	-8308
TNNT1	-4810	-4471
TNNT2	-8279	-8018
TNNT3	-8607	-6001
TPM1	-8365	-8005
TPM2	-8523	-7653
TPM3	-8389	-7363
TPM4	5492	6295
TTN	-3864	-6397
VIM	6874	7037

---

---

Branched-chain amino acid catabolism

Branched-chain amino acid catabolism

metric	value
setSize	21
pMANOVA	1.21e-07
p.adjustMANOVA	2.07e-06
s.dist	0.759
s.intact	-0.684
s.torn	-0.328
p.intact	5.6e-08
p.torn	0.00918

Top 20 genes

Gene	intact	torn
ACADSB	-8090	-6019
PPM1K	-8015	-6030
MCCC2	-7807	-5553
DLD	-7856	-5437
IVD	-7427	-5367
ACAT1	-8167	-4549
HIBADH	-7860	-4289
AUH	-7002	-4580
ALDH6A1	-8110	-3914
ECHS1	-7315	-4209
DBT	-7055	-4219
HIBCH	-7169	-3645
BCKDHA	-6282	-2742
ACAD8	-6746	-2334
SLC25A44	-4384	-2812
BCKDHB	-6549	-1877
MCCC1	-6732	-1152

Click HERE to show all gene set members

All member genes

	intact	torn
ACAD8	-6746	-2334
ACADSB	-8090	-6019
ACAT1	-8167	-4549
ALDH6A1	-8110	-3914
AUH	-7002	-4580
BCAT1	7081	7401
BCAT2	-6728	214
BCKDHA	-6282	-2742
BCKDHB	-6549	-1877
BCKDK	-5962	2224
DBT	-7055	-4219
DLD	-7856	-5437
ECHS1	-7315	-4209
HIBADH	-7860	-4289
HIBCH	-7169	-3645
HSD17B10	434	-3097
IVD	-7427	-5367
MCCC1	-6732	-1152
MCCC2	-7807	-5553
PPM1K	-8015	-6030
SLC25A44	-4384	-2812

---

---

The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport

metric	value
setSize	160
pMANOVA	1.53e-39
p.adjustMANOVA	2.24e-36
s.dist	0.751
s.intact	-0.611
s.torn	-0.436
p.intact	1.03e-40
p.torn	1.79e-21

Top 20 genes

Gene	intact	torn
UCP3	-8572	-6830
CYCS	-7755	-7529
NDUFB9	-7822	-7452
NDUFAF5	-6844	-8274
PDHX	-8084	-6771
MDH2	-8040	-6807
IDH2	-8356	-6545
NDUFAF6	-8226	-6644
NDUFV2	-7314	-7463
SUCLA2	-8071	-6730
COX5A	-7987	-6689
NDUFA9	-7515	-7107
UQCRFS1	-7919	-6737
NDUFA4	-7637	-6902
NDUFA5	-7754	-6774
UQCR10	-8129	-6389
PDK2	-8334	-6172
LDHB	-7904	-6486
ACO2	-8205	-6231
NNT	-8153	-6224

Click HERE to show all gene set members

All member genes

	intact	torn
ACAD9	-4363	2633
ACO2	-8205	-6231
ADHFE1	-8253	-5247
ATP5F1A	-7645	-6364
ATP5F1B	-7536	-6631
ATP5F1C	-5966	-6191
ATP5F1D	-7469	-6181
ATP5F1E	2008	1067
ATP5MC1	-7605	-5456
ATP5MC2	-7267	-5344
ATP5MC3	-6992	-5469
ATP5ME	-2122	1401
ATP5MF	-2922	-1373
ATP5MG	-4982	-3152
ATP5PB	-6063	-5439
ATP5PD	-5149	-2955
ATP5PF	-7131	-6008
ATP5PO	-7127	-5151
BSG	-2135	4200
COA1	-6890	-4487
COQ10A	-8394	-6036
COQ10B	7001	-999
COX11	-7301	-6625
COX14	-6818	-5406
COX16	-3655	-3865
COX18	-4551	-1129
COX19	-3458	3794
COX20	2583	-1535
COX4I1	-5679	-4299
COX5A	-7987	-6689
COX5B	-7229	-5236
COX6A1	6200	6571
COX6B1	-5976	-2832
COX6C	-6492	-6157
COX7A2L	-279	1790
COX7B	-7145	-5876
COX7C	-6809	-5090
COX8A	-6998	-6119
CS	-8054	-6269
CYC1	-7872	-6421
CYCS	-7755	-7529
D2HGDH	-4957	3466
DLAT	-7750	-6218
DLD	-7856	-5437
DLST	-6374	-4355
DMAC2L	-6386	-5479
ECSIT	-7163	-5276
ETFA	-7398	-5414
ETFB	-6397	-3147
ETFDH	-8136	-2651
FAHD1	-3561	-3101
FH	-7570	-5774
GLO1	-7174	-6671
GSTZ1	-5665	-5879
HAGH	-7118	-6233
IDH2	-8356	-6545
IDH3A	-7007	-5285
IDH3B	-6689	-6085
IDH3G	-4015	157
L2HGDH	-7887	-5773
LDHA	3772	4577
LDHB	-7904	-6486
LRPPRC	-7250	-4398
MDH2	-8040	-6807
ME1	-2190	-1491
ME2	-5287	-2017
ME3	-457	-1092
MPC1	-7211	-6064
MPC2	-6445	-6388
NDUFA1	-5013	-1869
NDUFA10	-7180	-4623
NDUFA11	-1729	776
NDUFA12	-6652	-6147
NDUFA13	-4109	-801
NDUFA2	-5561	-4159
NDUFA3	-6815	-723
NDUFA4	-7637	-6902
NDUFA5	-7754	-6774
NDUFA6	-5687	-4405
NDUFA7	-7879	-6365
NDUFA8	-6589	-5706
NDUFA9	-7515	-7107
NDUFAB1	-7245	-6596
NDUFAF1	-5412	-4937
NDUFAF2	-832	-4080
NDUFAF3	-4296	-990
NDUFAF4	-6389	-6062
NDUFAF5	-6844	-8274
NDUFAF6	-8226	-6644
NDUFAF7	-5208	321
NDUFB1	-5491	-5142
NDUFB10	-7339	-6056
NDUFB11	-6743	-4383
NDUFB2	-4947	-3728
NDUFB3	-6572	-4668
NDUFB4	-6614	-4484
NDUFB5	-7388	-6144
NDUFB6	-6086	-5073
NDUFB7	-5631	-4943
NDUFB8	-6139	-4450
NDUFB9	-7822	-7452
NDUFC1	-7815	-5629
NDUFC2	-6395	-5146
NDUFS1	-7954	-6335
NDUFS2	-7745	-5848
NDUFS3	-6714	-6623
NDUFS4	-6430	-5416
NDUFS5	-1940	-2121
NDUFS6	-4518	-3789
NDUFS7	-7676	-5397
NDUFS8	-5843	-5321
NDUFV1	-7265	-4505
NDUFV2	-7314	-7463
NDUFV3	-7003	-4239
NNT	-8153	-6224
NUBPL	-2636	-748
OGDH	-6983	-6864
PDHA1	-7678	-4488
PDHB	-7226	-6667
PDHX	-8084	-6771
PDK1	3534	7572
PDK2	-8334	-6172
PDK3	6056	3735
PDK4	-8361	-1219
PDP1	-6550	-1562
PDP2	-4556	-4957
PDPR	-2757	1925
PPARD	-3103	7138
RXRA	-5323	-542
SCO1	-3739	-2555
SCO2	7338	7271
SDHA	-7968	-6259
SDHB	-7660	-5567
SDHC	-5841	-3721
SDHD	-7840	-6271
SLC16A1	-923	5913
SLC16A3	7045	7339
SLC16A8	2240	1231
SLC25A14	5338	3092
SLC25A27	-6767	-4643
SUCLA2	-8071	-6730
SUCLG1	-6871	-5445
SUCLG2	-7110	-6011
SURF1	-4531	-314
TACO1	-6537	-5659
TIMMDC1	-6896	-5549
TMEM126B	528	-2289
TMEM186	-4089	-3251
TRAP1	-7397	-5335
UCP2	-829	302
UCP3	-8572	-6830
UQCR10	-8129	-6389
UQCR11	-6849	-4922
UQCRB	-7093	-5183
UQCRC1	-7215	-5719
UQCRC2	-7798	-6175
UQCRFS1	-7919	-6737
UQCRH	-4855	-3291
UQCRQ	-6252	-4582
VDAC1	-7456	-5675

---

---

Metal ion SLC transporters

Metal ion SLC transporters

metric	value
setSize	18
pMANOVA	0.000139
p.adjustMANOVA	0.00105
s.dist	0.743
s.intact	0.507
s.torn	0.543
p.intact	0.000197
p.torn	6.56e-05

Top 20 genes

Gene	intact	torn
SLC41A2	7230	7488
SLC39A6	6764	7432
SLC39A7	6678	7084
SLC31A1	7012	6734
SLC39A14	6307	6869
SLC11A1	5308	7203
SLC39A1	5985	5105
SLC11A2	4936	4948
SLC39A10	4337	5270
SLC30A1	5629	4011
SLC39A3	5377	4033
SLC39A8	2437	6671
SLC30A5	5169	3140
SLC39A4	1142	5561
CP	767	1581

Click HERE to show all gene set members

All member genes

	intact	torn
CP	767	1581
HEPH	2145	-1384
SLC11A1	5308	7203
SLC11A2	4936	4948
SLC30A1	5629	4011
SLC30A5	5169	3140
SLC31A1	7012	6734
SLC39A1	5985	5105
SLC39A10	4337	5270
SLC39A14	6307	6869
SLC39A3	5377	4033
SLC39A4	1142	5561
SLC39A6	6764	7432
SLC39A7	6678	7084
SLC39A8	2437	6671
SLC40A1	-5140	-2326
SLC41A1	-8332	-5757
SLC41A2	7230	7488

---

---

Syndecan interactions

Syndecan interactions

metric	value
setSize	26
pMANOVA	2.2e-06
p.adjustMANOVA	3.28e-05
s.dist	0.726
s.intact	0.574
s.torn	0.446
p.intact	4.09e-07
p.torn	8.38e-05

Top 20 genes

Gene	intact	torn
COL5A2	7246	7670
TNC	6859	7564
COL1A1	6602	7739
COL5A1	6590	7742
ITGB5	6544	7586
COL3A1	6336	7690
COL5A3	7056	6888
TGFB1	7048	6419
COL1A2	5619	7681
SDC2	7190	5911
PRKCA	5968	6927
CASK	5213	7499
FN1	5502	6492
ITGAV	7206	4725
ITGB1	6693	3328
SDC1	2969	5252
ACTN1	4969	2456
TRAPPC4	2381	959
SDC3	818	1897
SDC4	177	1127

Click HERE to show all gene set members

All member genes

	intact	torn
ACTN1	4969	2456
CASK	5213	7499
COL1A1	6602	7739
COL1A2	5619	7681
COL3A1	6336	7690
COL5A1	6590	7742
COL5A2	7246	7670
COL5A3	7056	6888
FGF2	680	-4725
FN1	5502	6492
ITGA2	1112	-5244
ITGA6	-4406	-7784
ITGAV	7206	4725
ITGB1	6693	3328
ITGB3	2869	-4157
ITGB4	-1589	-8159
ITGB5	6544	7586
PRKCA	5968	6927
SDC1	2969	5252
SDC2	7190	5911
SDC3	818	1897
SDC4	177	1127
TGFB1	7048	6419
THBS1	-1570	2331
TNC	6859	7564
TRAPPC4	2381	959

---

---

Glycogen synthesis

Glycogen synthesis

metric	value
setSize	13
pMANOVA	0.00109
p.adjustMANOVA	0.0055
s.dist	0.725
s.intact	-0.592
s.torn	-0.419
p.intact	0.000222
p.torn	0.00896

Top 20 genes

Gene	intact	torn
GYG1	-8277	-7966
EPM2A	-8330	-7330
GYS1	-8422	-6998
PPP1R3C	-8002	-5836
PGM1	-8259	-4863
UGP2	-6551	-5473
UBC	-5262	-6300
UBB	-6221	-4938
GBE1	-4789	-3375
GYG2	-6044	-2384
NHLRC1	-2148	-1539

Click HERE to show all gene set members

All member genes

	intact	torn
EPM2A	-8330	-7330
GBE1	-4789	-3375
GYG1	-8277	-7966
GYG2	-6044	-2384
GYS1	-8422	-6998
NHLRC1	-2148	-1539
PGM1	-8259	-4863
PPP1R3C	-8002	-5836
RPS27A	3318	3930
UBA52	-361	5203
UBB	-6221	-4938
UBC	-5262	-6300
UGP2	-6551	-5473

---

---

Olfactory Signaling Pathway

Olfactory Signaling Pathway

metric	value
setSize	25
pMANOVA	1e-10
p.adjustMANOVA	3.47e-09
s.dist	0.723
s.intact	-0.208
s.torn	-0.692
p.intact	0.0723
p.torn	2.04e-09

Top 20 genes

Gene	intact	torn
REEP1	-7892	-7869
OR56A1	-4598	-8150
ANO2	-4520	-8111
GNAL	-7322	-4553
OR7C1	-3963	-7836
OR1D2	-3276	-8377
OR6Y1	-3454	-7927
OR5AN1	-3569	-7562
OR4D9	-3507	-7035
OR10H5	-4593	-4808
OR8A1	-3217	-6765
OR10G3	-2034	-8266
OR2AT4	-1806	-8172
OR5A2	-2543	-5585
OR5A1	-1748	-7864
OR2M3	-1672	-8155
OR6C75	-1291	-7862
OR5AS1	-1059	-6136
OR14J1	-984	-6531
OR52K1	-449	-6832

Click HERE to show all gene set members

All member genes

	intact	torn
ADCY3	2429	-4521
ANO2	-4520	-8111
EBF1	2056	-4233
GNAL	-7322	-4553
GNB1	6751	6564
LDB1	-4293	4017
OR10G3	-2034	-8266
OR10H5	-4593	-4808
OR14J1	-984	-6531
OR1D2	-3276	-8377
OR1I1	788	-4700
OR2AT4	-1806	-8172
OR2M3	-1672	-8155
OR4D9	-3507	-7035
OR52K1	-449	-6832
OR56A1	-4598	-8150
OR5A1	-1748	-7864
OR5A2	-2543	-5585
OR5AN1	-3569	-7562
OR5AS1	-1059	-6136
OR6C75	-1291	-7862
OR6Y1	-3454	-7927
OR7C1	-3963	-7836
OR8A1	-3217	-6765
REEP1	-7892	-7869

---

---

Chondroitin sulfate biosynthesis

Chondroitin sulfate biosynthesis

metric	value
setSize	15
pMANOVA	0.00123
p.adjustMANOVA	0.00602
s.dist	0.692
s.intact	0.539
s.torn	0.435
p.intact	0.000304
p.torn	0.00357

Top 20 genes

Gene	intact	torn
CSGALNACT2	6465	7452
CHPF2	6794	6920
CHST11	6532	4985
BGN	3996	7647
CHSY1	6136	4813
CHPF	5804	4736
CSGALNACT1	6208	3113
CSPG4	7124	2593
CHST15	1048	4409
CHST3	1299	2523
CHST12	2622	705
CHSY3	1817	952
VCAN	3440	389

Click HERE to show all gene set members

All member genes

	intact	torn
BGN	3996	7647
CHPF	5804	4736
CHPF2	6794	6920
CHST11	6532	4985
CHST12	2622	705
CHST15	1048	4409
CHST3	1299	2523
CHST7	-1478	-4702
CHSY1	6136	4813
CHSY3	1817	952
CSGALNACT1	6208	3113
CSGALNACT2	6465	7452
CSPG4	7124	2593
DCN	-825	1664
VCAN	3440	389

---

---

Mitochondrial translation

Mitochondrial translation

metric	value
setSize	94
pMANOVA	1.94e-18
p.adjustMANOVA	4.05e-16
s.dist	0.69
s.intact	-0.526
s.torn	-0.446
p.intact	1.24e-18
p.torn	7.33e-14

Top 20 genes

Gene	intact	torn
MRPS9	-7677	-7185
MRPS35	-6931	-7531
MRPL33	-7662	-6618
MRPL46	-7377	-6845
MRPS28	-7381	-6464
MRPS18B	-7184	-6626
MRPS10	-7014	-6746
MRPS18A	-6797	-6880
MRPS7	-7312	-6333
MRPS27	-7344	-6226
MRPL39	-5759	-7857
MRPS15	-6969	-6301
MRPL19	-6858	-6080
MRPL12	-6719	-6082
ERAL1	-6882	-5900
MRPL15	-6752	-5998
GFM1	-6635	-6057
MRPL44	-7179	-5348
MRPL1	-6083	-6311
MRPS30	-7638	-4996

Click HERE to show all gene set members

All member genes

	intact	torn
AURKAIP1	-5577	-5170
CHCHD1	-682	2247
DAP3	-4702	-3815
ERAL1	-6882	-5900
GADD45GIP1	-1051	-1038
GFM1	-6635	-6057
GFM2	-6554	-5273
MRPL1	-6083	-6311
MRPL10	-7673	-4027
MRPL11	-6909	-3885
MRPL12	-6719	-6082
MRPL13	-2298	-57
MRPL14	-5446	-5136
MRPL15	-6752	-5998
MRPL16	-6177	-4148
MRPL17	7369	5119
MRPL18	-1855	-5432
MRPL19	-6858	-6080
MRPL2	-6286	-4906
MRPL20	-5596	-5817
MRPL21	-4480	-3621
MRPL22	-1543	-5084
MRPL23	-1724	-3843
MRPL24	-5849	-4290
MRPL27	-1144	2198
MRPL28	-1985	-922
MRPL3	-2114	-5534
MRPL30	-6598	-5225
MRPL32	-4287	-2282
MRPL33	-7662	-6618
MRPL34	-6575	-4618
MRPL35	-6066	-5302
MRPL36	-2424	-3019
MRPL37	-6952	-5431
MRPL38	-6303	-4693
MRPL39	-5759	-7857
MRPL4	-5965	-2929
MRPL40	-6166	-4857
MRPL41	-6388	-4602
MRPL42	-1815	-4130
MRPL43	-4333	-1130
MRPL44	-7179	-5348
MRPL45	-5371	-5091
MRPL46	-7377	-6845
MRPL47	-4027	-3314
MRPL48	-3156	-1394
MRPL49	-3887	-3756
MRPL50	-4116	-5229
MRPL51	-2333	219
MRPL52	-1552	-874
MRPL53	-5405	-3515
MRPL54	2684	4303
MRPL55	-2219	2773
MRPL57	-5174	-3331
MRPL58	-7291	-4434
MRPL9	-4411	-1399
MRPS10	-7014	-6746
MRPS11	-4632	-5455
MRPS12	-3821	-4518
MRPS14	-514	-1131
MRPS15	-6969	-6301
MRPS16	-6476	-4030
MRPS17	-5466	-5510
MRPS18A	-6797	-6880
MRPS18B	-7184	-6626
MRPS18C	-2233	-5695
MRPS2	-6941	-727
MRPS21	6816	6293
MRPS22	-5452	-5826
MRPS23	-133	-5945
MRPS24	-7016	-5216
MRPS25	-7829	-2914
MRPS26	-5047	-5575
MRPS27	-7344	-6226
MRPS28	-7381	-6464
MRPS30	-7638	-4996
MRPS31	-4419	-5808
MRPS33	-6675	-4174
MRPS34	-3342	-690
MRPS35	-6931	-7531
MRPS36	-4851	-2617
MRPS5	-6478	-1819
MRPS6	-739	-5009
MRPS7	-7312	-6333
MRPS9	-7677	-7185
MRRF	-6052	-3293
MTFMT	-5620	-4037
MTIF2	-3934	-4884
MTIF3	-4912	-3849
MTRF1L	-3386	-988
OXA1L	-6926	-4125
PTCD3	-7519	-4014
TSFM	-6427	-4954
TUFM	-6786	-4992

---

---

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

metric	value
setSize	12
pMANOVA	0.00361
p.adjustMANOVA	0.0148
s.dist	0.689
s.intact	0.558
s.torn	0.403
p.intact	0.000809
p.torn	0.0156

Top 20 genes

Gene	intact	torn
TNFSF11	7146	7093
TRAF2	4453	5961
TNFSF12	4211	5969
TNFRSF11A	6612	3680
LTBR	4360	4321
TRAF3	4112	3035
TNFSF13B	2511	3162
MAP3K14	1407	5349
TNFRSF12A	6476	911
BIRC2	2997	1287

Click HERE to show all gene set members

All member genes

	intact	torn
BIRC2	2997	1287
BIRC3	3725	-2105
CD40	-488	-3133
LTBR	4360	4321
MAP3K14	1407	5349
TNFRSF11A	6612	3680
TNFRSF12A	6476	911
TNFSF11	7146	7093
TNFSF12	4211	5969
TNFSF13B	2511	3162
TRAF2	4453	5961
TRAF3	4112	3035

---

---

Mitochondrial translation elongation

Mitochondrial translation elongation

metric	value
setSize	88
pMANOVA	3.3e-17
p.adjustMANOVA	6.02e-15
s.dist	0.688
s.intact	-0.523
s.torn	-0.448
p.intact	2.21e-17
p.torn	3.85e-13

Top 20 genes

Gene	intact	torn
MRPS9	-7677	-7185
MRPS35	-6931	-7531
MRPL33	-7662	-6618
MRPL46	-7377	-6845
MRPS28	-7381	-6464
MRPS18B	-7184	-6626
MRPS10	-7014	-6746
MRPS18A	-6797	-6880
MRPS7	-7312	-6333
MRPS27	-7344	-6226
MRPL39	-5759	-7857
MRPS15	-6969	-6301
MRPL19	-6858	-6080
MRPL12	-6719	-6082
ERAL1	-6882	-5900
MRPL15	-6752	-5998
GFM1	-6635	-6057
MRPL44	-7179	-5348
MRPL1	-6083	-6311
MRPS30	-7638	-4996

Click HERE to show all gene set members

All member genes

	intact	torn
AURKAIP1	-5577	-5170
CHCHD1	-682	2247
DAP3	-4702	-3815
ERAL1	-6882	-5900
GADD45GIP1	-1051	-1038
GFM1	-6635	-6057
MRPL1	-6083	-6311
MRPL10	-7673	-4027
MRPL11	-6909	-3885
MRPL12	-6719	-6082
MRPL13	-2298	-57
MRPL14	-5446	-5136
MRPL15	-6752	-5998
MRPL16	-6177	-4148
MRPL17	7369	5119
MRPL18	-1855	-5432
MRPL19	-6858	-6080
MRPL2	-6286	-4906
MRPL20	-5596	-5817
MRPL21	-4480	-3621
MRPL22	-1543	-5084
MRPL23	-1724	-3843
MRPL24	-5849	-4290
MRPL27	-1144	2198
MRPL28	-1985	-922
MRPL3	-2114	-5534
MRPL30	-6598	-5225
MRPL32	-4287	-2282
MRPL33	-7662	-6618
MRPL34	-6575	-4618
MRPL35	-6066	-5302
MRPL36	-2424	-3019
MRPL37	-6952	-5431
MRPL38	-6303	-4693
MRPL39	-5759	-7857
MRPL4	-5965	-2929
MRPL40	-6166	-4857
MRPL41	-6388	-4602
MRPL42	-1815	-4130
MRPL43	-4333	-1130
MRPL44	-7179	-5348
MRPL45	-5371	-5091
MRPL46	-7377	-6845
MRPL47	-4027	-3314
MRPL48	-3156	-1394
MRPL49	-3887	-3756
MRPL50	-4116	-5229
MRPL51	-2333	219
MRPL52	-1552	-874
MRPL53	-5405	-3515
MRPL54	2684	4303
MRPL55	-2219	2773
MRPL57	-5174	-3331
MRPL58	-7291	-4434
MRPL9	-4411	-1399
MRPS10	-7014	-6746
MRPS11	-4632	-5455
MRPS12	-3821	-4518
MRPS14	-514	-1131
MRPS15	-6969	-6301
MRPS16	-6476	-4030
MRPS17	-5466	-5510
MRPS18A	-6797	-6880
MRPS18B	-7184	-6626
MRPS18C	-2233	-5695
MRPS2	-6941	-727
MRPS21	6816	6293
MRPS22	-5452	-5826
MRPS23	-133	-5945
MRPS24	-7016	-5216
MRPS25	-7829	-2914
MRPS26	-5047	-5575
MRPS27	-7344	-6226
MRPS28	-7381	-6464
MRPS30	-7638	-4996
MRPS31	-4419	-5808
MRPS33	-6675	-4174
MRPS34	-3342	-690
MRPS35	-6931	-7531
MRPS36	-4851	-2617
MRPS5	-6478	-1819
MRPS6	-739	-5009
MRPS7	-7312	-6333
MRPS9	-7677	-7185
OXA1L	-6926	-4125
PTCD3	-7519	-4014
TSFM	-6427	-4954
TUFM	-6786	-4992

---

---

Pyruvate metabolism and Citric Acid (TCA) cycle

Pyruvate metabolism and Citric Acid (TCA) cycle

metric	value
setSize	51
pMANOVA	2.11e-12
p.adjustMANOVA	1.02e-10
s.dist	0.685
s.intact	-0.589
s.torn	-0.35
p.intact	3.42e-13
p.torn	1.5e-05

Top 20 genes

Gene	intact	torn
PDHX	-8084	-6771
MDH2	-8040	-6807
IDH2	-8356	-6545
SUCLA2	-8071	-6730
PDK2	-8334	-6172
LDHB	-7904	-6486
ACO2	-8205	-6231
NNT	-8153	-6224
CS	-8054	-6269
SDHA	-7968	-6259
SDHD	-7840	-6271
DLAT	-7750	-6218
PDHB	-7226	-6667
OGDH	-6983	-6864
GLO1	-7174	-6671
L2HGDH	-7887	-5773
HAGH	-7118	-6233
MPC1	-7211	-6064
FH	-7570	-5774
ADHFE1	-8253	-5247

Click HERE to show all gene set members

All member genes

	intact	torn
ACO2	-8205	-6231
ADHFE1	-8253	-5247
BSG	-2135	4200
CS	-8054	-6269
D2HGDH	-4957	3466
DLAT	-7750	-6218
DLD	-7856	-5437
DLST	-6374	-4355
FAHD1	-3561	-3101
FH	-7570	-5774
GLO1	-7174	-6671
GSTZ1	-5665	-5879
HAGH	-7118	-6233
IDH2	-8356	-6545
IDH3A	-7007	-5285
IDH3B	-6689	-6085
IDH3G	-4015	157
L2HGDH	-7887	-5773
LDHA	3772	4577
LDHB	-7904	-6486
MDH2	-8040	-6807
ME1	-2190	-1491
ME2	-5287	-2017
ME3	-457	-1092
MPC1	-7211	-6064
MPC2	-6445	-6388
NNT	-8153	-6224
OGDH	-6983	-6864
PDHA1	-7678	-4488
PDHB	-7226	-6667
PDHX	-8084	-6771
PDK1	3534	7572
PDK2	-8334	-6172
PDK3	6056	3735
PDK4	-8361	-1219
PDP1	-6550	-1562
PDP2	-4556	-4957
PDPR	-2757	1925
PPARD	-3103	7138
RXRA	-5323	-542
SDHA	-7968	-6259
SDHB	-7660	-5567
SDHC	-5841	-3721
SDHD	-7840	-6271
SLC16A1	-923	5913
SLC16A3	7045	7339
SLC16A8	2240	1231
SUCLA2	-8071	-6730
SUCLG1	-6871	-5445
SUCLG2	-7110	-6011
VDAC1	-7456	-5675

---

---

Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

metric	value
setSize	25
pMANOVA	1.82e-05
p.adjustMANOVA	0.000205
s.dist	0.683
s.intact	-0.426
s.torn	-0.533
p.intact	0.000225
p.torn	3.89e-06

Top 20 genes

Gene	intact	torn
CAMK2A	-8430	-7805
SCN1B	-8260	-7855
CAMK2G	-7820	-7771
CAMK2B	-8603	-6818
SCN4B	-7113	-8082
FGF13	-6959	-7918
CACNB1	-8125	-6003
CAMK2D	-7751	-6084
SCN3B	-7331	-5604
SCN7A	-7651	-5337
SCN4A	-8596	-4340
CACNG6	-3913	-4925
CACNB2	-2112	-6649
SCN3A	-1740	-7670
SCN2B	-8421	-1486
SCN2A	-1472	-7840
SCN8A	-2825	-3230

Click HERE to show all gene set members

All member genes

	intact	torn
CACNA1C	391	-2591
CACNA2D2	-7310	1028
CACNB1	-8125	-6003
CACNB2	-2112	-6649
CACNG6	-3913	-4925
CACNG8	287	-6989
CALM1	4372	-3021
CAMK2A	-8430	-7805
CAMK2B	-8603	-6818
CAMK2D	-7751	-6084
CAMK2G	-7820	-7771
FGF11	-376	7530
FGF13	-6959	-7918
FGF14	4273	-1870
RANGRF	2571	2395
SCN1B	-8260	-7855
SCN2A	-1472	-7840
SCN2B	-8421	-1486
SCN3A	-1740	-7670
SCN3B	-7331	-5604
SCN4A	-8596	-4340
SCN4B	-7113	-8082
SCN7A	-7651	-5337
SCN8A	-2825	-3230
SCN9A	3015	-6227

---

---

Mitochondrial translation initiation

Mitochondrial translation initiation

metric	value
setSize	88
pMANOVA	9.09e-17
p.adjustMANOVA	1.33e-14
s.dist	0.68
s.intact	-0.515
s.torn	-0.443
p.intact	6.36e-17
p.torn	6.65e-13

Top 20 genes

Gene	intact	torn
MRPS9	-7677	-7185
MRPS35	-6931	-7531
MRPL33	-7662	-6618
MRPL46	-7377	-6845
MRPS28	-7381	-6464
MRPS18B	-7184	-6626
MRPS10	-7014	-6746
MRPS18A	-6797	-6880
MRPS7	-7312	-6333
MRPS27	-7344	-6226
MRPL39	-5759	-7857
MRPS15	-6969	-6301
MRPL19	-6858	-6080
MRPL12	-6719	-6082
ERAL1	-6882	-5900
MRPL15	-6752	-5998
MRPL44	-7179	-5348
MRPL1	-6083	-6311
MRPS30	-7638	-4996
MRPL37	-6952	-5431

Click HERE to show all gene set members

All member genes

	intact	torn
AURKAIP1	-5577	-5170
CHCHD1	-682	2247
DAP3	-4702	-3815
ERAL1	-6882	-5900
GADD45GIP1	-1051	-1038
MRPL1	-6083	-6311
MRPL10	-7673	-4027
MRPL11	-6909	-3885
MRPL12	-6719	-6082
MRPL13	-2298	-57
MRPL14	-5446	-5136
MRPL15	-6752	-5998
MRPL16	-6177	-4148
MRPL17	7369	5119
MRPL18	-1855	-5432
MRPL19	-6858	-6080
MRPL2	-6286	-4906
MRPL20	-5596	-5817
MRPL21	-4480	-3621
MRPL22	-1543	-5084
MRPL23	-1724	-3843
MRPL24	-5849	-4290
MRPL27	-1144	2198
MRPL28	-1985	-922
MRPL3	-2114	-5534
MRPL30	-6598	-5225
MRPL32	-4287	-2282
MRPL33	-7662	-6618
MRPL34	-6575	-4618
MRPL35	-6066	-5302
MRPL36	-2424	-3019
MRPL37	-6952	-5431
MRPL38	-6303	-4693
MRPL39	-5759	-7857
MRPL4	-5965	-2929
MRPL40	-6166	-4857
MRPL41	-6388	-4602
MRPL42	-1815	-4130
MRPL43	-4333	-1130
MRPL44	-7179	-5348
MRPL45	-5371	-5091
MRPL46	-7377	-6845
MRPL47	-4027	-3314
MRPL48	-3156	-1394
MRPL49	-3887	-3756
MRPL50	-4116	-5229
MRPL51	-2333	219
MRPL52	-1552	-874
MRPL53	-5405	-3515
MRPL54	2684	4303
MRPL55	-2219	2773
MRPL57	-5174	-3331
MRPL58	-7291	-4434
MRPL9	-4411	-1399
MRPS10	-7014	-6746
MRPS11	-4632	-5455
MRPS12	-3821	-4518
MRPS14	-514	-1131
MRPS15	-6969	-6301
MRPS16	-6476	-4030
MRPS17	-5466	-5510
MRPS18A	-6797	-6880
MRPS18B	-7184	-6626
MRPS18C	-2233	-5695
MRPS2	-6941	-727
MRPS21	6816	6293
MRPS22	-5452	-5826
MRPS23	-133	-5945
MRPS24	-7016	-5216
MRPS25	-7829	-2914
MRPS26	-5047	-5575
MRPS27	-7344	-6226
MRPS28	-7381	-6464
MRPS30	-7638	-4996
MRPS31	-4419	-5808
MRPS33	-6675	-4174
MRPS34	-3342	-690
MRPS35	-6931	-7531
MRPS36	-4851	-2617
MRPS5	-6478	-1819
MRPS6	-739	-5009
MRPS7	-7312	-6333
MRPS9	-7677	-7185
MTFMT	-5620	-4037
MTIF2	-3934	-4884
MTIF3	-4912	-3849
OXA1L	-6926	-4125
PTCD3	-7519	-4014

---

---

Retrograde neurotrophin signalling

Retrograde neurotrophin signalling

metric	value
setSize	12
pMANOVA	0.00657
p.adjustMANOVA	0.0251
s.dist	0.678
s.intact	0.443
s.torn	0.513
p.intact	0.00783
p.torn	0.00207

Top 20 genes

Gene	intact	torn
DNM1	5009	6828
CLTC	6719	4932
AP2M1	5884	5367
CLTA	5595	4564
AP2S1	4468	4526
DNAL4	4697	3721
AP2B1	3253	4845
NGF	2554	5406
AP2A2	2181	3196

Click HERE to show all gene set members

All member genes

	intact	torn
AP2A1	-672	5805
AP2A2	2181	3196
AP2B1	3253	4845
AP2M1	5884	5367
AP2S1	4468	4526
CLTA	5595	4564
CLTC	6719	4932
DNAL4	4697	3721
DNM1	5009	6828
DNM2	-2282	1864
DNM3	-1041	-4835
NGF	2554	5406

---

---

Mitochondrial translation termination

Mitochondrial translation termination

metric	value
setSize	88
pMANOVA	8.79e-17
p.adjustMANOVA	1.33e-14
s.dist	0.678
s.intact	-0.517
s.torn	-0.439
p.intact	4.72e-17
p.torn	1.14e-12

Top 20 genes

Gene	intact	torn
MRPS9	-7677	-7185
MRPS35	-6931	-7531
MRPL33	-7662	-6618
MRPL46	-7377	-6845
MRPS28	-7381	-6464
MRPS18B	-7184	-6626
MRPS10	-7014	-6746
MRPS18A	-6797	-6880
MRPS7	-7312	-6333
MRPS27	-7344	-6226
MRPL39	-5759	-7857
MRPS15	-6969	-6301
MRPL19	-6858	-6080
MRPL12	-6719	-6082
ERAL1	-6882	-5900
MRPL15	-6752	-5998
MRPL44	-7179	-5348
MRPL1	-6083	-6311
MRPS30	-7638	-4996
MRPL37	-6952	-5431

Click HERE to show all gene set members

All member genes

	intact	torn
AURKAIP1	-5577	-5170
CHCHD1	-682	2247
DAP3	-4702	-3815
ERAL1	-6882	-5900
GADD45GIP1	-1051	-1038
GFM2	-6554	-5273
MRPL1	-6083	-6311
MRPL10	-7673	-4027
MRPL11	-6909	-3885
MRPL12	-6719	-6082
MRPL13	-2298	-57
MRPL14	-5446	-5136
MRPL15	-6752	-5998
MRPL16	-6177	-4148
MRPL17	7369	5119
MRPL18	-1855	-5432
MRPL19	-6858	-6080
MRPL2	-6286	-4906
MRPL20	-5596	-5817
MRPL21	-4480	-3621
MRPL22	-1543	-5084
MRPL23	-1724	-3843
MRPL24	-5849	-4290
MRPL27	-1144	2198
MRPL28	-1985	-922
MRPL3	-2114	-5534
MRPL30	-6598	-5225
MRPL32	-4287	-2282
MRPL33	-7662	-6618
MRPL34	-6575	-4618
MRPL35	-6066	-5302
MRPL36	-2424	-3019
MRPL37	-6952	-5431
MRPL38	-6303	-4693
MRPL39	-5759	-7857
MRPL4	-5965	-2929
MRPL40	-6166	-4857
MRPL41	-6388	-4602
MRPL42	-1815	-4130
MRPL43	-4333	-1130
MRPL44	-7179	-5348
MRPL45	-5371	-5091
MRPL46	-7377	-6845
MRPL47	-4027	-3314
MRPL48	-3156	-1394
MRPL49	-3887	-3756
MRPL50	-4116	-5229
MRPL51	-2333	219
MRPL52	-1552	-874
MRPL53	-5405	-3515
MRPL54	2684	4303
MRPL55	-2219	2773
MRPL57	-5174	-3331
MRPL58	-7291	-4434
MRPL9	-4411	-1399
MRPS10	-7014	-6746
MRPS11	-4632	-5455
MRPS12	-3821	-4518
MRPS14	-514	-1131
MRPS15	-6969	-6301
MRPS16	-6476	-4030
MRPS17	-5466	-5510
MRPS18A	-6797	-6880
MRPS18B	-7184	-6626
MRPS18C	-2233	-5695
MRPS2	-6941	-727
MRPS21	6816	6293
MRPS22	-5452	-5826
MRPS23	-133	-5945
MRPS24	-7016	-5216
MRPS25	-7829	-2914
MRPS26	-5047	-5575
MRPS27	-7344	-6226
MRPS28	-7381	-6464
MRPS30	-7638	-4996
MRPS31	-4419	-5808
MRPS33	-6675	-4174
MRPS34	-3342	-690
MRPS35	-6931	-7531
MRPS36	-4851	-2617
MRPS5	-6478	-1819
MRPS6	-739	-5009
MRPS7	-7312	-6333
MRPS9	-7677	-7185
MRRF	-6052	-3293
MTRF1L	-3386	-988
OXA1L	-6926	-4125
PTCD3	-7519	-4014

---

---

Cristae formation

Cristae formation

metric	value
setSize	29
pMANOVA	5.29e-06
p.adjustMANOVA	7.01e-05
s.dist	0.672
s.intact	-0.521
s.torn	-0.424
p.intact	1.21e-06
p.torn	7.66e-05

Top 20 genes

Gene	intact	torn
CHCHD3	-7847	-7142
TMEM11	-7247	-7717
APOO	-7694	-7036
ATP5F1B	-7536	-6631
APOOL	-7213	-6875
ATP5F1A	-7645	-6364
ATP5F1D	-7469	-6181
IMMT	-6573	-6805
ATP5PF	-7131	-6008
ATP5MC1	-7605	-5456
ATP5MC2	-7267	-5344
ATP5MC3	-6992	-5469
ATP5F1C	-5966	-6191
ATP5PO	-7127	-5151
DMAC2L	-6386	-5479
ATP5PB	-6063	-5439
MTX2	-5306	-5863
SAMM50	-7343	-3790
DNAJC11	-6484	-3750
HSPA9	-5764	-3830

Click HERE to show all gene set members

All member genes

	intact	torn
APOO	-7694	-7036
APOOL	-7213	-6875
ATP5F1A	-7645	-6364
ATP5F1B	-7536	-6631
ATP5F1C	-5966	-6191
ATP5F1D	-7469	-6181
ATP5F1E	2008	1067
ATP5MC1	-7605	-5456
ATP5MC2	-7267	-5344
ATP5MC3	-6992	-5469
ATP5ME	-2122	1401
ATP5MF	-2922	-1373
ATP5MG	-4982	-3152
ATP5PB	-6063	-5439
ATP5PD	-5149	-2955
ATP5PF	-7131	-6008
ATP5PO	-7127	-5151
CHCHD3	-7847	-7142
CHCHD6	5054	4701
DMAC2L	-6386	-5479
DNAJC11	-6484	-3750
HSPA9	-5764	-3830
IMMT	-6573	-6805
MICOS10	3124	3988
MICOS13	-952	90
MTX1	6620	4744
MTX2	-5306	-5863
SAMM50	-7343	-3790
TMEM11	-7247	-7717

---

---

Interleukin-10 signaling

Interleukin-10 signaling

metric	value
setSize	29
pMANOVA	1.06e-05
p.adjustMANOVA	0.000131
s.dist	0.667
s.intact	0.469
s.torn	0.474
p.intact	1.22e-05
p.torn	1.01e-05

Top 20 genes

Gene	intact	torn
CXCL8	7371	7626
CCR5	6603	7609
LIF	7341	6792
TIMP1	4718	7487
CD86	5281	6548
CCL3	6044	5513
TNF	7394	4499
CCL4	3499	7649
CCR1	5633	4666
IL10RA	3909	6710
PTGS2	3627	6978
PTAFR	4014	4183
CCL2	7349	2179
TNFRSF1A	4103	3267
IL1R1	3260	3834
CXCL1	6728	1677
IL10	4110	2674
CSF1	6142	1258
IL10RB	2966	2320
TYK2	879	5300

Click HERE to show all gene set members

All member genes

	intact	torn
CCL2	7349	2179
CCL3	6044	5513
CCL4	3499	7649
CCL5	-1072	-2725
CCR1	5633	4666
CCR2	3681	1191
CCR5	6603	7609
CD86	5281	6548
CSF1	6142	1258
CXCL1	6728	1677
CXCL2	2762	-637
CXCL8	7371	7626
FPR1	-1364	5290
ICAM1	2516	-810
IL10	4110	2674
IL10RA	3909	6710
IL10RB	2966	2320
IL18	1363	1017
IL1R1	3260	3834
JAK1	-6263	-5219
LIF	7341	6792
PTAFR	4014	4183
PTGS2	3627	6978
STAT3	-6924	2338
TIMP1	4718	7487
TNF	7394	4499
TNFRSF1A	4103	3267
TNFRSF1B	-1860	3031
TYK2	879	5300

---

---

Chondroitin sulfate/dermatan sulfate metabolism

Chondroitin sulfate/dermatan sulfate metabolism

metric	value
setSize	41
pMANOVA	7.85e-08
p.adjustMANOVA	1.41e-06
s.dist	0.664
s.intact	0.499
s.torn	0.439
p.intact	3.24e-08
p.torn	1.17e-06

Top 20 genes

Gene	intact	torn
IDS	7375	6668
DSEL	6412	7596
CSGALNACT2	6465	7452
CHPF2	6794	6920
GPC6	6478	6738
DSE	5602	7751
HEXB	6712	6347
SDC2	7190	5911
B3GALT6	7333	5705
XYLT2	5864	6740
B3GAT3	6616	5737
CHST11	6532	4985
XYLT1	4305	7315
BGN	3996	7647
UST	5668	5335
CHSY1	6136	4813
CHPF	5804	4736
CHST14	4788	5684
HEXA	4558	4640
ARSB	6069	3374

Click HERE to show all gene set members

All member genes

	intact	torn
AGRN	803	-5711
ARSB	6069	3374
B3GALT6	7333	5705
B3GAT3	6616	5737
B4GALT7	2428	7390
BGN	3996	7647
CHPF	5804	4736
CHPF2	6794	6920
CHST11	6532	4985
CHST12	2622	705
CHST14	4788	5684
CHST15	1048	4409
CHST3	1299	2523
CHST7	-1478	-4702
CHSY1	6136	4813
CHSY3	1817	952
CSGALNACT1	6208	3113
CSGALNACT2	6465	7452
CSPG4	7124	2593
DCN	-825	1664
DSE	5602	7751
DSEL	6412	7596
GPC1	-7225	-7676
GPC2	1269	1768
GPC3	-963	-3665
GPC4	-6738	-2738
GPC6	6478	6738
HEXA	4558	4640
HEXB	6712	6347
HSPG2	659	-4336
HYAL1	2512	508
IDS	7375	6668
IDUA	3671	5340
SDC1	2969	5252
SDC2	7190	5911
SDC3	818	1897
SDC4	177	1127
UST	5668	5335
VCAN	3440	389
XYLT1	4305	7315
XYLT2	5864	6740

---

---

G beta:gamma signalling through BTK

G beta:gamma signalling through BTK

metric	value
setSize	12
pMANOVA	0.00646
p.adjustMANOVA	0.0248
s.dist	0.663
s.intact	0.526
s.torn	0.403
p.intact	0.0016
p.torn	0.0157

Top 20 genes

Gene	intact	torn
GNB2	7253	6549
GNB1	6751	6564
GNB3	5329	7617
BTK	5006	6569
GNG2	4750	2921
GNB5	2751	4348
GNB4	5846	1993
GNG7	1244	5521
GNG12	4719	1129

Click HERE to show all gene set members

All member genes

	intact	torn
BTK	5006	6569
GNB1	6751	6564
GNB2	7253	6549
GNB3	5329	7617
GNB4	5846	1993
GNB5	2751	4348
GNG10	3224	-1726
GNG11	-471	-7383
GNG12	4719	1129
GNG2	4750	2921
GNG5	-1997	1368
GNG7	1244	5521

---

---

Mitochondrial calcium ion transport

Mitochondrial calcium ion transport

metric	value
setSize	22
pMANOVA	4.68e-05
p.adjustMANOVA	0.000446
s.dist	0.659
s.intact	-0.55
s.torn	-0.364
p.intact	8.07e-06
p.torn	0.00312

Top 20 genes

Gene	intact	torn
SLC8A3	-8345	-7540
AKAP1	-8231	-7400
MCU	-7742	-7041
AFG3L2	-7591	-6708
VDAC3	-7693	-6460
VDAC1	-7456	-5675
MICU1	-7026	-5624
VDAC2	-6350	-5450
SMDT1	-6424	-4900
MICU2	-5882	-5304
STOML2	-6218	-4825
LETM1	-5562	-2973
PHB2	-6184	-1782
PHB	-3583	-2581
YME1L1	-4324	-1645
MICU3	-6650	-971
PMPCA	-6888	-838
PMPCB	-2507	-1223

Click HERE to show all gene set members

All member genes

	intact	torn
AFG3L2	-7591	-6708
AKAP1	-8231	-7400
LETM1	-5562	-2973
MCU	-7742	-7041
MCUB	5631	4475
MICU1	-7026	-5624
MICU2	-5882	-5304
MICU3	-6650	-971
PARL	-3013	328
PHB	-3583	-2581
PHB2	-6184	-1782
PMPCA	-6888	-838
PMPCB	-2507	-1223
SLC8A3	-8345	-7540
SLC8B1	5107	1858
SMDT1	-6424	-4900
SPG7	-2925	1019
STOML2	-6218	-4825
VDAC1	-7456	-5675
VDAC2	-6350	-5450
VDAC3	-7693	-6460
YME1L1	-4324	-1645

---

---

ADP signalling through P2Y purinoceptor 12

ADP signalling through P2Y purinoceptor 12

metric	value
setSize	14
pMANOVA	0.00128
p.adjustMANOVA	0.00621
s.dist	0.654
s.intact	0.56
s.torn	0.338
p.intact	0.000287
p.torn	0.0284

Top 20 genes

Gene	intact	torn
GNB2	7253	6549
GNB1	6751	6564
GNB3	5329	7617
GNAI2	6606	5451
GNAI3	6922	5025
GNG2	4750	2921
GNB5	2751	4348
GNB4	5846	1993
GNG7	1244	5521
GNG12	4719	1129

Click HERE to show all gene set members

All member genes

	intact	torn
GNAI1	2671	-5264
GNAI2	6606	5451
GNAI3	6922	5025
GNB1	6751	6564
GNB2	7253	6549
GNB3	5329	7617
GNB4	5846	1993
GNB5	2751	4348
GNG10	3224	-1726
GNG11	-471	-7383
GNG12	4719	1129
GNG2	4750	2921
GNG5	-1997	1368
GNG7	1244	5521

---

---

Regulation of CDH11 gene transcription

Regulation of CDH11 gene transcription

metric	value
setSize	10
pMANOVA	0.00952
p.adjustMANOVA	0.0341
s.dist	0.653
s.intact	0.345
s.torn	0.555
p.intact	0.0592
p.torn	0.00237

Top 20 genes

Gene	intact	torn
ZEB2	7463	6431
CDH11	5243	7430
PRDM8	5257	6852
SNAI1	5206	6793
HOXC8	5764	1817
SP1	350	5394
FOXF1	61	1574

Click HERE to show all gene set members

All member genes

	intact	torn
BHLHE22	-277	7428
CDH11	5243	7430
FOXF1	61	1574
HEYL	-4474	-7102
HOXC8	5764	1817
ILF3	-2276	5263
PRDM8	5257	6852
SNAI1	5206	6793
SP1	350	5394
ZEB2	7463	6431

---

---

Carnitine metabolism

Carnitine metabolism

metric	value
setSize	14
pMANOVA	0.00088
p.adjustMANOVA	0.00469
s.dist	0.651
s.intact	-0.57
s.torn	-0.315
p.intact	0.000224
p.torn	0.0415

Top 20 genes

Gene	intact	torn
PRKAA2	-8538	-6729
PRKAB2	-7549	-7003
CPT1B	-8456	-5599
ACACB	-8218	-5495
CPT2	-6922	-5282
MID1IP1	-5730	-5056
THRSP	-6375	-4241
SLC22A5	-7990	-3297
SLC25A20	-6419	-3193
RXRA	-5323	-542
PRKAG2	-150	-1745

Click HERE to show all gene set members

All member genes

	intact	torn
ACACA	596	1809
ACACB	-8218	-5495
CPT1A	1984	-558
CPT1B	-8456	-5599
CPT2	-6922	-5282
MID1IP1	-5730	-5056
PPARD	-3103	7138
PRKAA2	-8538	-6729
PRKAB2	-7549	-7003
PRKAG2	-150	-1745
RXRA	-5323	-542
SLC22A5	-7990	-3297
SLC25A20	-6419	-3193
THRSP	-6375	-4241

---

---

Scavenging by Class A Receptors

Scavenging by Class A Receptors

metric	value
setSize	16
pMANOVA	0.000933
p.adjustMANOVA	0.0049
s.dist	0.638
s.intact	0.538
s.torn	0.343
p.intact	0.000194
p.torn	0.0176

Top 20 genes

Gene	intact	torn
COL1A1	6602	7739
HSP90B1	6958	7162
COL3A1	6336	7690
COL1A2	5619	7681
CALR	5472	6772
MSR1	4760	6251
FTL	4977	5873
COLEC12	5664	3820
FTH1	4405	4407
MARCO	5074	2133
SCARA5	4021	1523

Click HERE to show all gene set members

All member genes

	intact	torn
APOB	-1644	-6351
APOE	1667	-2214
CALR	5472	6772
COL1A1	6602	7739
COL1A2	5619	7681
COL3A1	6336	7690
COL4A1	3657	-5377
COL4A2	5341	-3112
COLEC12	5664	3820
FTH1	4405	4407
FTL	4977	5873
HSP90B1	6958	7162
MARCO	5074	2133
MASP1	-8182	-4466
MSR1	4760	6251
SCARA5	4021	1523

---

---

Signal regulatory protein family interactions

Signal regulatory protein family interactions

metric	value
setSize	11
pMANOVA	0.0179
p.adjustMANOVA	0.0579
s.dist	0.637
s.intact	0.474
s.torn	0.426
p.intact	0.00651
p.torn	0.0144

Top 20 genes

Gene	intact	torn
SRC	6846	6867
CD47	7174	4578
TYROBP	5150	6356
SIRPA	5230	6232
PTPN6	4980	6182
GRB2	3742	6049
PTK2B	3465	4459
SIRPB1	2742	3964
SKAP2	1964	153

Click HERE to show all gene set members

All member genes

	intact	torn
CD47	7174	4578
GRB2	3742	6049
PTK2	-286	-7188
PTK2B	3465	4459
PTPN11	-4966	-3042
PTPN6	4980	6182
SIRPA	5230	6232
SIRPB1	2742	3964
SKAP2	1964	153
SRC	6846	6867
TYROBP	5150	6356

---

---

RUNX3 regulates p14-ARF

RUNX3 regulates p14-ARF

metric	value
setSize	10
pMANOVA	0.0268
p.adjustMANOVA	0.0799
s.dist	0.622
s.intact	0.39
s.torn	0.485
p.intact	0.0329
p.torn	0.00789

Top 20 genes

Gene	intact	torn
CCND1	7037	6756
TGFB1	7048	6419
RUNX1	5328	6922
RUNX3	5530	4527
CBFB	5686	1250
CDKN2A	1699	3870

Click HERE to show all gene set members

All member genes

	intact	torn
BRD2	-160	3464
CBFB	5686	1250
CCND1	7037	6756
CDKN2A	1699	3870
EP300	-4834	5238
HDAC4	-7020	-1220
KRAS	5639	-989
RUNX1	5328	6922
RUNX3	5530	4527
TGFB1	7048	6419

---

---

Formation of annular gap junctions

Formation of annular gap junctions

metric	value
setSize	11
pMANOVA	0.0225
p.adjustMANOVA	0.0692
s.dist	0.622
s.intact	0.428
s.torn	0.451
p.intact	0.0139
p.torn	0.00963

Top 20 genes

Gene	intact	torn
GJA1	7198	7533
ACTG1	6780	6722
ACTB	6571	5482
DNM1	5009	6828
CLTC	6719	4932
AP2M1	5884	5367
CLTA	5595	4564
DAB2	4286	5122

Click HERE to show all gene set members

All member genes

	intact	torn
ACTB	6571	5482
ACTG1	6780	6722
AP2M1	5884	5367
CLTA	5595	4564
CLTB	-5373	-4818
CLTC	6719	4932
CLTCL1	-8393	-6795
DAB2	4286	5122
DNM1	5009	6828
DNM2	-2282	1864
GJA1	7198	7533

---

---

RHO GTPases activate IQGAPs

RHO GTPases activate IQGAPs

metric	value
setSize	22
pMANOVA	6.66e-05
p.adjustMANOVA	0.000575
s.dist	0.621
s.intact	0.535
s.torn	0.315
p.intact	1.38e-05
p.torn	0.0104

Top 20 genes

Gene	intact	torn
ACTG1	6780	6722
IQGAP1	7236	6199
IQGAP3	7390	5932
TUBB2A	6868	5864
CTNNA1	7149	5484
TUBB3	6963	5440
ACTB	6571	5482
TUBA1B	7247	3991
IQGAP2	4373	6464
MEN1	3610	6711
TUBA1A	5947	3199
TUBB6	7063	2423
TUBA1C	6988	2404
CTNNB1	4298	2575
RAC1	6497	542

Click HERE to show all gene set members

All member genes

	intact	torn
ACTB	6571	5482
ACTG1	6780	6722
CALM1	4372	-3021
CDC42	4018	-1248
CLIP1	-7034	-7091
CTNNA1	7149	5484
CTNNB1	4298	2575
IQGAP1	7236	6199
IQGAP2	4373	6464
IQGAP3	7390	5932
MEN1	3610	6711
RAC1	6497	542
TUBA1A	5947	3199
TUBA1B	7247	3991
TUBA1C	6988	2404
TUBA4A	-8494	-7581
TUBA8	-8458	-6784
TUBB2A	6868	5864
TUBB2B	-2347	7708
TUBB3	6963	5440
TUBB4B	5934	-1928
TUBB6	7063	2423

---

---

Gap junction degradation

Gap junction degradation

metric	value
setSize	12
pMANOVA	0.0175
p.adjustMANOVA	0.0569
s.dist	0.615
s.intact	0.442
s.torn	0.428
p.intact	0.00805
p.torn	0.0102

Top 20 genes

Gene	intact	torn
GJA1	7198	7533
ACTG1	6780	6722
ACTB	6571	5482
DNM1	5009	6828
CLTC	6719	4932
AP2M1	5884	5367
CLTA	5595	4564
DAB2	4286	5122
MYO6	4221	1169

Click HERE to show all gene set members

All member genes

	intact	torn
ACTB	6571	5482
ACTG1	6780	6722
AP2M1	5884	5367
CLTA	5595	4564
CLTB	-5373	-4818
CLTC	6719	4932
CLTCL1	-8393	-6795
DAB2	4286	5122
DNM1	5009	6828
DNM2	-2282	1864
GJA1	7198	7533
MYO6	4221	1169

---

---

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

metric	value
setSize	13
pMANOVA	0.0132
p.adjustMANOVA	0.045
s.dist	0.611
s.intact	0.418
s.torn	0.445
p.intact	0.00902
p.torn	0.0055

Top 20 genes

Gene	intact	torn
FZD2	6077	6799
CLTC	6719	4932
ROR2	5514	5799
AP2M1	5884	5367
CLTA	5595	4564
AP2S1	4468	4526
ROR1	6569	2588
AP2B1	3253	4845
WNT5A	1748	5365
AP2A2	2181	3196

Click HERE to show all gene set members

All member genes

	intact	torn
AP2A1	-672	5805
AP2A2	2181	3196
AP2B1	3253	4845
AP2M1	5884	5367
AP2S1	4468	4526
CLTA	5595	4564
CLTB	-5373	-4818
CLTC	6719	4932
FZD2	6077	6799
FZD5	-5209	-6120
ROR1	6569	2588
ROR2	5514	5799
WNT5A	1748	5365

---

---

FCGR3A-mediated phagocytosis

FCGR3A-mediated phagocytosis

metric	value
setSize	57
pMANOVA	4.52e-09
p.adjustMANOVA	9.43e-08
s.dist	0.599
s.intact	0.47
s.torn	0.372
p.intact	8.5e-10
p.torn	1.22e-06

Top 20 genes

Gene	intact	torn
SRC	6846	6867
ACTG1	6780	6722
MYO9B	6578	6768
MYO5A	6993	5937
ARPC4	6936	5626
SYK	5282	7144
CYFIP1	5751	6437
ACTB	6571	5482
BAIAP2	6767	5253
ARPC3	7059	4865
WIPF2	6445	5175
BTK	5006	6569
NCKAP1L	4845	6624
ARPC1B	6581	4664
DOCK1	4701	6370
FGR	5336	5356
BRK1	5576	4955
HCK	4480	5657
WIPF1	3516	7176
VAV2	4311	5688

Click HERE to show all gene set members

All member genes

	intact	torn
ABI1	6898	2641
ABI2	6760	1766
ABL1	402	4573
ACTB	6571	5482
ACTG1	6780	6722
ACTR2	4004	4242
ACTR3	6000	2864
ARPC1A	-2209	-3634
ARPC1B	6581	4664
ARPC2	6797	3506
ARPC3	7059	4865
ARPC4	6936	5626
ARPC5	5949	3887
BAIAP2	6767	5253
BRK1	5576	4955
BTK	5006	6569
CDC42	4018	-1248
CRK	4915	168
CYFIP1	5751	6437
CYFIP2	-198	-7567
DOCK1	4701	6370
ELMO1	4196	1700
ELMO2	-1428	1719
FCGR3A	2148	2343
FGR	5336	5356
FYN	2870	1392
GRB2	3742	6049
HCK	4480	5657
LYN	4448	5169
MAPK1	3334	-1920
MAPK3	1937	-1841
MYH2	-8640	-5195
MYH9	1969	-2432
MYO10	1313	5980
MYO1C	4346	3561
MYO5A	6993	5937
MYO9B	6578	6768
NCK1	-382	-4690
NCKAP1	-3351	-5862
NCKAP1L	4845	6624
NCKIPSD	-698	7161
PTK2	-286	-7188
RAC1	6497	542
SRC	6846	6867
SYK	5282	7144
VAV1	2770	5582
VAV2	4311	5688
VAV3	4939	4704
WAS	3170	7173
WASF1	4652	4703
WASF2	3744	3939
WASF3	-5297	1935
WASL	-4817	-4441
WIPF1	3516	7176
WIPF2	6445	5175
WIPF3	-8188	-6620
YES1	1603	-299

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.3               GGally_2.2.0               
##  [3] beeswarm_0.4.0              gtools_3.9.5               
##  [5] echarts4r_0.4.5             kableExtra_1.3.4           
##  [7] topconfects_1.18.0          limma_3.58.1               
##  [9] eulerr_7.0.0                mitch_1.14.0               
## [11] MASS_7.3-60                 fgsea_1.28.0               
## [13] gplots_3.1.3                DESeq2_1.42.0              
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0             
## [17] MatrixGenerics_1.14.0       matrixStats_1.2.0          
## [19] GenomicRanges_1.54.1        GenomeInfoDb_1.38.5        
## [21] IRanges_2.36.0              S4Vectors_0.40.2           
## [23] BiocGenerics_0.48.1         reshape2_1.4.4             
## [25] lubridate_1.9.3             forcats_1.0.0              
## [27] stringr_1.5.1               dplyr_1.1.4                
## [29] purrr_1.0.2                 readr_2.1.4                
## [31] tidyr_1.3.0                 tibble_3.2.1               
## [33] ggplot2_3.4.4               tidyverse_2.0.0            
## [35] zoo_1.8-12                  R.utils_2.12.3             
## [37] R.oo_1.25.0                 R.methodsS3_1.8.2          
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.2            
##  [4] magrittr_2.0.3          compiler_4.3.2          systemfonts_1.0.5      
##  [7] vctrs_0.6.5             rvest_1.0.3             pkgconfig_2.0.3        
## [10] crayon_1.5.2            fastmap_1.1.1           XVector_0.42.0         
## [13] ellipsis_0.3.2          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.2.1          rmarkdown_2.25         
## [19] tzdb_0.4.0              xfun_0.41               cachem_1.0.8           
## [22] zlibbioc_1.48.0         jsonlite_1.8.8          highr_0.10             
## [25] later_1.3.2             DelayedArray_0.28.0     BiocParallel_1.36.0    
## [28] parallel_4.3.2          R6_2.5.1                bslib_0.6.1            
## [31] stringi_1.8.3           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [34] assertthat_0.2.1        Rcpp_1.0.11             knitr_1.45             
## [37] httpuv_1.6.13           Matrix_1.6-4            timechange_0.2.0       
## [40] tidyselect_1.2.0        yaml_2.3.8              rstudioapi_0.15.0      
## [43] abind_1.4-5             codetools_0.2-19        lattice_0.22-5         
## [46] plyr_1.8.9              shiny_1.8.0             withr_2.5.2            
## [49] evaluate_0.23           ggstats_0.5.1           xml2_1.3.6             
## [52] pillar_1.9.0            KernSmooth_2.23-22      generics_0.1.3         
## [55] RCurl_1.98-1.13         hms_1.1.3               munsell_0.5.0          
## [58] scales_1.3.0            xtable_1.8-4            glue_1.6.2             
## [61] tools_4.3.2             data.table_1.14.10      webshot_0.5.5          
## [64] locfit_1.5-9.8          fastmatch_1.1-4         cowplot_1.1.2          
## [67] grid_4.3.2              colorspace_2.1-0        GenomeInfoDbData_1.2.11
## [70] cli_3.6.2               fansi_1.0.6             viridisLite_0.4.2      
## [73] S4Arrays_1.2.0          svglite_2.1.3           gtable_0.3.4           
## [76] sass_0.4.8              digest_0.6.33           SparseArray_1.2.3      
## [79] farver_2.1.1            htmlwidgets_1.6.4       htmltools_0.5.7        
## [82] lifecycle_1.0.4         httr_1.4.7              statmod_1.5.0          
## [85] mime_0.12

END of report