Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2024-03-12
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
| intact | torn | |
|---|---|---|
| 5_8S_rRNA | -3.451453 | 1.4758490 |
| 7SK | -1.426939 | -0.5096905 |
| A1BG | 1.529759 | 2.8137638 |
| A1BG.AS1 | 1.877187 | 1.2793604 |
| A2M | -1.546889 | -4.1729641 |
| A2M.AS1 | -1.368094 | -0.8450553 |
Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 16178 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8225 |
| num_profile_genes_not_in_sets | 7953 |
| profile_pearson_correl | 0.64572 |
| profile_spearman_correl | 0.68579 |
Here is a plot of the input profiles. Note the dynamic ranges.
Here is the contour plot of the profile including all detected genes.
Input genesets
Here are some metrics about the gene sets used:
GMT file of genesets: ReactomePathways_2023-09-01.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 2612 |
| num_genesets_excluded | 1153 |
| num_genesets_included | 1459 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 435 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets
## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.intact | s.torn | p.intact | p.torn |
|---|---|---|---|---|---|---|---|---|
| Expression and translocation of olfactory receptors | 21 | 7.22e-11 | 2.57e-09 | 0.806 | -0.2450 | -0.76900 | 5.24e-02 | 1.07e-09 |
| Olfactory Signaling Pathway | 25 | 1.00e-10 | 3.47e-09 | 0.723 | -0.2080 | -0.69200 | 7.23e-02 | 2.04e-09 |
| Regulation of FOXO transcriptional activity by acetylation | 10 | 1.66e-03 | 7.64e-03 | 0.491 | -0.4900 | -0.02180 | 7.28e-03 | 9.05e-01 |
| Beta-oxidation of very long chain fatty acids | 10 | 1.68e-03 | 7.66e-03 | 0.519 | -0.5150 | -0.06180 | 4.78e-03 | 7.35e-01 |
| HDMs demethylate histones | 21 | 1.70e-05 | 1.96e-04 | 0.384 | -0.0725 | 0.37700 | 5.65e-01 | 2.79e-03 |
| FOXO-mediated transcription of cell death genes | 15 | 2.05e-04 | 1.46e-03 | 0.488 | -0.4850 | -0.05740 | 1.16e-03 | 7.01e-01 |
| cGMP effects | 14 | 3.61e-04 | 2.34e-03 | 0.498 | -0.0712 | -0.49300 | 6.44e-01 | 1.40e-03 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 11 | 4.69e-03 | 1.86e-02 | 0.424 | 0.4240 | 0.01260 | 1.50e-02 | 9.42e-01 |
| Signaling by Leptin | 11 | 1.73e-03 | 7.82e-03 | 0.533 | -0.5210 | -0.11200 | 2.76e-03 | 5.20e-01 |
| RHO GTPases activate CIT | 19 | 1.64e-03 | 7.59e-03 | 0.272 | 0.2330 | -0.14100 | 7.86e-02 | 2.88e-01 |
| Branched-chain amino acid catabolism | 21 | 1.21e-07 | 2.07e-06 | 0.759 | -0.6840 | -0.32800 | 5.60e-08 | 9.18e-03 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 30 | 3.06e-05 | 3.17e-04 | 0.348 | 0.3480 | -0.00285 | 9.70e-04 | 9.78e-01 |
| Nucleosome assembly | 30 | 3.06e-05 | 3.17e-04 | 0.348 | 0.3480 | -0.00285 | 9.70e-04 | 9.78e-01 |
| Nitric oxide stimulates guanylate cyclase | 17 | 1.31e-04 | 9.99e-04 | 0.568 | -0.1860 | -0.53700 | 1.84e-01 | 1.26e-04 |
| Degradation of cysteine and homocysteine | 14 | 1.45e-03 | 6.81e-03 | 0.511 | -0.4910 | -0.14300 | 1.47e-03 | 3.53e-01 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 24 | 4.31e-05 | 4.20e-04 | 0.456 | 0.4460 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 24 | 4.31e-05 | 4.20e-04 | 0.456 | 0.4460 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 24 | 4.31e-05 | 4.20e-04 | 0.456 | 0.4460 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | 24 | 4.31e-05 | 4.20e-04 | 0.456 | 0.4460 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Impaired BRCA2 binding to PALB2 | 23 | 6.95e-05 | 5.83e-04 | 0.464 | 0.4510 | 0.11000 | 1.83e-04 | 3.60e-01 |
| Platelet calcium homeostasis | 23 | 1.39e-03 | 6.64e-03 | 0.275 | 0.0695 | -0.26600 | 5.64e-01 | 2.71e-02 |
| Leading Strand Synthesis | 14 | 2.22e-03 | 9.61e-03 | 0.497 | 0.4760 | 0.14200 | 2.04e-03 | 3.58e-01 |
| Polymerase switching | 14 | 2.22e-03 | 9.61e-03 | 0.497 | 0.4760 | 0.14200 | 2.04e-03 | 3.58e-01 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 15 | 4.70e-04 | 2.84e-03 | 0.577 | -0.5390 | -0.20700 | 3.00e-04 | 1.66e-01 |
| EPHA-mediated growth cone collapse | 23 | 2.61e-03 | 1.11e-02 | 0.252 | 0.2370 | -0.08620 | 4.94e-02 | 4.74e-01 |
| Cell-extracellular matrix interactions | 18 | 1.10e-02 | 3.85e-02 | 0.252 | 0.2410 | -0.07560 | 7.70e-02 | 5.79e-01 |
| RHO GTPases activate PAKs | 21 | 6.32e-03 | 2.44e-02 | 0.240 | 0.0912 | -0.22200 | 4.70e-01 | 7.85e-02 |
| Peroxisomal lipid metabolism | 26 | 9.39e-05 | 7.44e-04 | 0.438 | -0.4230 | -0.11400 | 1.86e-04 | 3.15e-01 |
| Resolution of Sister Chromatid Cohesion | 109 | 1.56e-14 | 1.42e-12 | 0.347 | 0.3450 | 0.03550 | 4.91e-10 | 5.22e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 26 | 8.06e-05 | 6.61e-04 | 0.448 | 0.4310 | 0.12300 | 1.42e-04 | 2.76e-01 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 39 | 9.03e-06 | 1.14e-04 | 0.359 | 0.3560 | 0.04850 | 1.20e-04 | 6.00e-01 |
| Diseases of DNA Double-Strand Break Repair | 39 | 9.03e-06 | 1.14e-04 | 0.359 | 0.3560 | 0.04850 | 1.20e-04 | 6.00e-01 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | 10 | 5.72e-05 | 5.18e-04 | 0.945 | -0.8040 | -0.49700 | 1.08e-05 | 6.54e-03 |
| Laminin interactions | 29 | 4.86e-04 | 2.91e-03 | 0.302 | 0.0048 | -0.30200 | 9.64e-01 | 4.93e-03 |
| Homologous DNA Pairing and Strand Exchange | 41 | 3.98e-06 | 5.58e-05 | 0.373 | 0.3670 | 0.06260 | 4.71e-05 | 4.88e-01 |
| Mitochondrial Fatty Acid Beta-Oxidation | 34 | 1.28e-06 | 1.99e-05 | 0.502 | -0.4720 | -0.17200 | 1.90e-06 | 8.34e-02 |
| Activation of ATR in response to replication stress | 31 | 9.06e-04 | 4.77e-03 | 0.261 | 0.2580 | -0.03400 | 1.28e-02 | 7.43e-01 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 86 | 5.30e-10 | 1.55e-08 | 0.309 | 0.3080 | 0.01710 | 7.83e-07 | 7.84e-01 |
| Amplification of signal from the kinetochores | 86 | 5.30e-10 | 1.55e-08 | 0.309 | 0.3080 | 0.01710 | 7.83e-07 | 7.84e-01 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 38 | 3.24e-05 | 3.30e-04 | 0.354 | 0.3490 | 0.06060 | 2.00e-04 | 5.18e-01 |
| Sema4D in semaphorin signaling | 24 | 9.17e-03 | 3.30e-02 | 0.203 | 0.1350 | -0.15100 | 2.51e-01 | 2.00e-01 |
| Peroxisomal protein import | 56 | 2.44e-09 | 5.77e-08 | 0.469 | -0.4430 | -0.15600 | 1.02e-08 | 4.30e-02 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 7.69e-03 | 2.85e-02 | 0.495 | -0.4620 | -0.17800 | 3.92e-03 | 2.66e-01 |
| Impaired BRCA2 binding to RAD51 | 33 | 2.34e-04 | 1.61e-03 | 0.344 | 0.3390 | 0.06220 | 7.63e-04 | 5.36e-01 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 23 | 7.36e-04 | 4.04e-03 | 0.440 | -0.4160 | -0.14600 | 5.62e-04 | 2.27e-01 |
| Diseases of DNA repair | 48 | 3.15e-05 | 3.24e-04 | 0.297 | 0.2960 | 0.02910 | 3.96e-04 | 7.28e-01 |
| EML4 and NUDC in mitotic spindle formation | 100 | 2.94e-10 | 9.52e-09 | 0.309 | 0.3070 | 0.04250 | 1.19e-07 | 4.63e-01 |
| Pyruvate metabolism | 27 | 1.58e-04 | 1.17e-03 | 0.465 | -0.4320 | -0.17100 | 1.02e-04 | 1.25e-01 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 32 | 2.74e-05 | 2.93e-04 | 0.472 | 0.4370 | 0.17700 | 1.88e-05 | 8.25e-02 |
| Sulfur amino acid metabolism | 25 | 1.02e-03 | 5.30e-03 | 0.409 | -0.3870 | -0.13200 | 8.04e-04 | 2.55e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.intact | s.torn | p.intact | p.torn |
|---|---|---|---|---|---|---|---|---|
| Expression and translocation of olfactory receptors | 21 | 7.22e-11 | 2.57e-09 | 0.8060 | -0.245000 | -0.76900 | 5.24e-02 | 1.07e-09 |
| Olfactory Signaling Pathway | 25 | 1.00e-10 | 3.47e-09 | 0.7230 | -0.208000 | -0.69200 | 7.23e-02 | 2.04e-09 |
| Regulation of FOXO transcriptional activity by acetylation | 10 | 1.66e-03 | 7.64e-03 | 0.4910 | -0.490000 | -0.02180 | 7.28e-03 | 9.05e-01 |
| Beta-oxidation of very long chain fatty acids | 10 | 1.68e-03 | 7.66e-03 | 0.5190 | -0.515000 | -0.06180 | 4.78e-03 | 7.35e-01 |
| HDMs demethylate histones | 21 | 1.70e-05 | 1.96e-04 | 0.3840 | -0.072500 | 0.37700 | 5.65e-01 | 2.79e-03 |
| FOXO-mediated transcription of cell death genes | 15 | 2.05e-04 | 1.46e-03 | 0.4880 | -0.485000 | -0.05740 | 1.16e-03 | 7.01e-01 |
| cGMP effects | 14 | 3.61e-04 | 2.34e-03 | 0.4980 | -0.071200 | -0.49300 | 6.44e-01 | 1.40e-03 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 11 | 4.69e-03 | 1.86e-02 | 0.4240 | 0.424000 | 0.01260 | 1.50e-02 | 9.42e-01 |
| Signaling by Leptin | 11 | 1.73e-03 | 7.82e-03 | 0.5330 | -0.521000 | -0.11200 | 2.76e-03 | 5.20e-01 |
| RHO GTPases activate CIT | 19 | 1.64e-03 | 7.59e-03 | 0.2720 | 0.233000 | -0.14100 | 7.86e-02 | 2.88e-01 |
| Branched-chain amino acid catabolism | 21 | 1.21e-07 | 2.07e-06 | 0.7590 | -0.684000 | -0.32800 | 5.60e-08 | 9.18e-03 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 30 | 3.06e-05 | 3.17e-04 | 0.3480 | 0.348000 | -0.00285 | 9.70e-04 | 9.78e-01 |
| Nucleosome assembly | 30 | 3.06e-05 | 3.17e-04 | 0.3480 | 0.348000 | -0.00285 | 9.70e-04 | 9.78e-01 |
| Nitric oxide stimulates guanylate cyclase | 17 | 1.31e-04 | 9.99e-04 | 0.5680 | -0.186000 | -0.53700 | 1.84e-01 | 1.26e-04 |
| Degradation of cysteine and homocysteine | 14 | 1.45e-03 | 6.81e-03 | 0.5110 | -0.491000 | -0.14300 | 1.47e-03 | 3.53e-01 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 24 | 4.31e-05 | 4.20e-04 | 0.4560 | 0.446000 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 24 | 4.31e-05 | 4.20e-04 | 0.4560 | 0.446000 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 24 | 4.31e-05 | 4.20e-04 | 0.4560 | 0.446000 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | 24 | 4.31e-05 | 4.20e-04 | 0.4560 | 0.446000 | 0.09860 | 1.57e-04 | 4.03e-01 |
| Impaired BRCA2 binding to PALB2 | 23 | 6.95e-05 | 5.83e-04 | 0.4640 | 0.451000 | 0.11000 | 1.83e-04 | 3.60e-01 |
| Platelet calcium homeostasis | 23 | 1.39e-03 | 6.64e-03 | 0.2750 | 0.069500 | -0.26600 | 5.64e-01 | 2.71e-02 |
| Leading Strand Synthesis | 14 | 2.22e-03 | 9.61e-03 | 0.4970 | 0.476000 | 0.14200 | 2.04e-03 | 3.58e-01 |
| Polymerase switching | 14 | 2.22e-03 | 9.61e-03 | 0.4970 | 0.476000 | 0.14200 | 2.04e-03 | 3.58e-01 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 15 | 4.70e-04 | 2.84e-03 | 0.5770 | -0.539000 | -0.20700 | 3.00e-04 | 1.66e-01 |
| EPHA-mediated growth cone collapse | 23 | 2.61e-03 | 1.11e-02 | 0.2520 | 0.237000 | -0.08620 | 4.94e-02 | 4.74e-01 |
| Cell-extracellular matrix interactions | 18 | 1.10e-02 | 3.85e-02 | 0.2520 | 0.241000 | -0.07560 | 7.70e-02 | 5.79e-01 |
| RHO GTPases activate PAKs | 21 | 6.32e-03 | 2.44e-02 | 0.2400 | 0.091200 | -0.22200 | 4.70e-01 | 7.85e-02 |
| Peroxisomal lipid metabolism | 26 | 9.39e-05 | 7.44e-04 | 0.4380 | -0.423000 | -0.11400 | 1.86e-04 | 3.15e-01 |
| Resolution of Sister Chromatid Cohesion | 109 | 1.56e-14 | 1.42e-12 | 0.3470 | 0.345000 | 0.03550 | 4.91e-10 | 5.22e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 26 | 8.06e-05 | 6.61e-04 | 0.4480 | 0.431000 | 0.12300 | 1.42e-04 | 2.76e-01 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 39 | 9.03e-06 | 1.14e-04 | 0.3590 | 0.356000 | 0.04850 | 1.20e-04 | 6.00e-01 |
| Diseases of DNA Double-Strand Break Repair | 39 | 9.03e-06 | 1.14e-04 | 0.3590 | 0.356000 | 0.04850 | 1.20e-04 | 6.00e-01 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | 10 | 5.72e-05 | 5.18e-04 | 0.9450 | -0.804000 | -0.49700 | 1.08e-05 | 6.54e-03 |
| Laminin interactions | 29 | 4.86e-04 | 2.91e-03 | 0.3020 | 0.004800 | -0.30200 | 9.64e-01 | 4.93e-03 |
| Homologous DNA Pairing and Strand Exchange | 41 | 3.98e-06 | 5.58e-05 | 0.3730 | 0.367000 | 0.06260 | 4.71e-05 | 4.88e-01 |
| Mitochondrial Fatty Acid Beta-Oxidation | 34 | 1.28e-06 | 1.99e-05 | 0.5020 | -0.472000 | -0.17200 | 1.90e-06 | 8.34e-02 |
| Activation of ATR in response to replication stress | 31 | 9.06e-04 | 4.77e-03 | 0.2610 | 0.258000 | -0.03400 | 1.28e-02 | 7.43e-01 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 86 | 5.30e-10 | 1.55e-08 | 0.3090 | 0.308000 | 0.01710 | 7.83e-07 | 7.84e-01 |
| Amplification of signal from the kinetochores | 86 | 5.30e-10 | 1.55e-08 | 0.3090 | 0.308000 | 0.01710 | 7.83e-07 | 7.84e-01 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 38 | 3.24e-05 | 3.30e-04 | 0.3540 | 0.349000 | 0.06060 | 2.00e-04 | 5.18e-01 |
| Sema4D in semaphorin signaling | 24 | 9.17e-03 | 3.30e-02 | 0.2030 | 0.135000 | -0.15100 | 2.51e-01 | 2.00e-01 |
| Peroxisomal protein import | 56 | 2.44e-09 | 5.77e-08 | 0.4690 | -0.443000 | -0.15600 | 1.02e-08 | 4.30e-02 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 7.69e-03 | 2.85e-02 | 0.4950 | -0.462000 | -0.17800 | 3.92e-03 | 2.66e-01 |
| Impaired BRCA2 binding to RAD51 | 33 | 2.34e-04 | 1.61e-03 | 0.3440 | 0.339000 | 0.06220 | 7.63e-04 | 5.36e-01 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 23 | 7.36e-04 | 4.04e-03 | 0.4400 | -0.416000 | -0.14600 | 5.62e-04 | 2.27e-01 |
| Diseases of DNA repair | 48 | 3.15e-05 | 3.24e-04 | 0.2970 | 0.296000 | 0.02910 | 3.96e-04 | 7.28e-01 |
| EML4 and NUDC in mitotic spindle formation | 100 | 2.94e-10 | 9.52e-09 | 0.3090 | 0.307000 | 0.04250 | 1.19e-07 | 4.63e-01 |
| Pyruvate metabolism | 27 | 1.58e-04 | 1.17e-03 | 0.4650 | -0.432000 | -0.17100 | 1.02e-04 | 1.25e-01 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 32 | 2.74e-05 | 2.93e-04 | 0.4720 | 0.437000 | 0.17700 | 1.88e-05 | 8.25e-02 |
| Sulfur amino acid metabolism | 25 | 1.02e-03 | 5.30e-03 | 0.4090 | -0.387000 | -0.13200 | 8.04e-04 | 2.55e-01 |
| Mitochondrial tRNA aminoacylation | 21 | 1.97e-03 | 8.82e-03 | 0.4380 | -0.409000 | -0.15400 | 1.16e-03 | 2.21e-01 |
| Carnitine metabolism | 14 | 8.80e-04 | 4.69e-03 | 0.6510 | -0.570000 | -0.31500 | 2.24e-04 | 4.15e-02 |
| Adrenaline,noradrenaline inhibits insulin secretion | 22 | 8.42e-03 | 3.06e-02 | 0.3210 | 0.315000 | 0.06110 | 1.05e-02 | 6.20e-01 |
| Kinesins | 44 | 4.86e-06 | 6.63e-05 | 0.4160 | 0.392000 | 0.13900 | 6.71e-06 | 1.10e-01 |
| Polymerase switching on the C-strand of the telomere | 26 | 2.38e-03 | 1.02e-02 | 0.3500 | 0.339000 | 0.08680 | 2.77e-03 | 4.44e-01 |
| DNA strand elongation | 31 | 3.09e-04 | 2.06e-03 | 0.3940 | 0.374000 | 0.12200 | 3.11e-04 | 2.38e-01 |
| Mitotic Spindle Checkpoint | 103 | 6.76e-09 | 1.37e-07 | 0.2620 | 0.262000 | 0.01040 | 4.52e-06 | 8.56e-01 |
| Chromosome Maintenance | 92 | 5.88e-08 | 1.07e-06 | 0.2670 | 0.267000 | 0.01980 | 1.00e-05 | 7.43e-01 |
| Processing of SMDT1 | 15 | 1.71e-03 | 7.75e-03 | 0.5870 | -0.520000 | -0.27300 | 4.90e-04 | 6.68e-02 |
| Resolution of D-Loop Structures | 33 | 3.26e-05 | 3.30e-04 | 0.4690 | 0.431000 | 0.18500 | 1.82e-05 | 6.64e-02 |
| RHOB GTPase cycle | 65 | 1.71e-05 | 1.96e-04 | 0.2410 | 0.241000 | -0.00520 | 7.80e-04 | 9.42e-01 |
| Smooth Muscle Contraction | 36 | 1.18e-04 | 9.09e-04 | 0.3880 | -0.122000 | -0.36800 | 2.04e-01 | 1.31e-04 |
| Lagging Strand Synthesis | 20 | 8.24e-03 | 3.00e-02 | 0.3750 | 0.357000 | 0.11400 | 5.67e-03 | 3.78e-01 |
| RHO GTPases Activate Formins | 123 | 5.38e-12 | 2.31e-10 | 0.3360 | 0.325000 | 0.08540 | 4.76e-10 | 1.02e-01 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 51 | 2.11e-12 | 1.02e-10 | 0.6850 | -0.589000 | -0.35000 | 3.42e-13 | 1.50e-05 |
| Telomere C-strand (Lagging Strand) Synthesis | 34 | 1.17e-03 | 5.81e-03 | 0.3180 | 0.309000 | 0.07260 | 1.79e-03 | 4.64e-01 |
| NR1H2 and NR1H3-mediated signaling | 39 | 5.39e-03 | 2.11e-02 | 0.1730 | -0.082800 | 0.15200 | 3.71e-01 | 9.95e-02 |
| Extension of Telomeres | 49 | 9.16e-05 | 7.36e-04 | 0.3060 | 0.299000 | 0.06450 | 2.92e-04 | 4.35e-01 |
| Glyoxylate metabolism and glycine degradation | 23 | 1.86e-09 | 4.61e-08 | 0.9290 | -0.763000 | -0.52900 | 2.29e-10 | 1.12e-05 |
| Cell Cycle Checkpoints | 236 | 3.05e-14 | 2.35e-12 | 0.1760 | 0.159000 | -0.07510 | 2.75e-05 | 4.74e-02 |
| G2/M DNA damage checkpoint | 56 | 3.76e-04 | 2.39e-03 | 0.2000 | 0.196000 | -0.03680 | 1.10e-02 | 6.34e-01 |
| Separation of Sister Chromatids | 172 | 1.35e-10 | 4.59e-09 | 0.1770 | 0.163000 | -0.07030 | 2.37e-04 | 1.12e-01 |
| Apoptotic cleavage of cellular proteins | 35 | 7.32e-03 | 2.74e-02 | 0.2000 | 0.196000 | -0.03680 | 4.47e-02 | 7.07e-01 |
| G2/M Checkpoints | 123 | 1.88e-07 | 3.12e-06 | 0.1680 | 0.081200 | -0.14700 | 1.20e-01 | 4.76e-03 |
| Eukaryotic Translation Elongation | 93 | 2.05e-13 | 1.36e-11 | 0.4930 | 0.217000 | 0.44300 | 2.92e-04 | 1.54e-13 |
| Selenocysteine synthesis | 92 | 2.98e-13 | 1.81e-11 | 0.4940 | 0.218000 | 0.44300 | 2.99e-04 | 2.12e-13 |
| ADP signalling through P2Y purinoceptor 12 | 14 | 1.28e-03 | 6.21e-03 | 0.6540 | 0.560000 | 0.33800 | 2.87e-04 | 2.84e-02 |
| Peptide chain elongation | 88 | 8.55e-14 | 6.24e-12 | 0.5290 | 0.248000 | 0.46800 | 5.96e-05 | 3.33e-14 |
| RHO GTPases activate IQGAPs | 22 | 6.66e-05 | 5.75e-04 | 0.6210 | 0.535000 | 0.31500 | 1.38e-05 | 1.04e-02 |
| Mitophagy | 28 | 2.86e-03 | 1.21e-02 | 0.3600 | -0.340000 | -0.12000 | 1.86e-03 | 2.72e-01 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 94 | 6.48e-13 | 3.50e-11 | 0.4840 | 0.216000 | 0.43300 | 3.04e-04 | 4.03e-13 |
| Formation of a pool of free 40S subunits | 100 | 2.72e-11 | 1.07e-09 | 0.4150 | 0.164000 | 0.38100 | 4.55e-03 | 4.60e-11 |
| HDR through Single Strand Annealing (SSA) | 35 | 3.64e-03 | 1.49e-02 | 0.2840 | 0.277000 | 0.06300 | 4.57e-03 | 5.19e-01 |
| TBC/RABGAPs | 43 | 7.86e-03 | 2.89e-02 | 0.1680 | -0.053100 | 0.16000 | 5.47e-01 | 7.03e-02 |
| HDR through Homologous Recombination (HRR) | 65 | 7.43e-06 | 9.61e-05 | 0.3270 | 0.311000 | 0.09930 | 1.42e-05 | 1.66e-01 |
| Regulation of CDH11 gene transcription | 10 | 9.52e-03 | 3.41e-02 | 0.6530 | 0.345000 | 0.55500 | 5.92e-02 | 2.37e-03 |
| Somitogenesis | 50 | 5.99e-05 | 5.32e-04 | 0.3520 | -0.121000 | -0.33000 | 1.38e-01 | 5.35e-05 |
| FOXO-mediated transcription | 56 | 2.31e-04 | 1.60e-03 | 0.2720 | -0.266000 | -0.05760 | 5.84e-04 | 4.56e-01 |
| Selenoamino acid metabolism | 114 | 2.68e-12 | 1.22e-10 | 0.4120 | 0.168000 | 0.37600 | 1.97e-03 | 4.08e-12 |
| SUMOylation of transcription cofactors | 44 | 1.02e-02 | 3.61e-02 | 0.1550 | -0.068700 | 0.13800 | 4.31e-01 | 1.12e-01 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 110 | 2.07e-10 | 6.85e-09 | 0.3690 | 0.136000 | 0.34300 | 1.35e-02 | 5.30e-10 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 114 | 3.47e-11 | 1.30e-09 | 0.3820 | 0.147000 | 0.35300 | 6.93e-03 | 7.77e-11 |
| Nonsense-Mediated Decay (NMD) | 114 | 3.47e-11 | 1.30e-09 | 0.3820 | 0.147000 | 0.35300 | 6.93e-03 | 7.77e-11 |
| Viral mRNA Translation | 88 | 5.87e-13 | 3.29e-11 | 0.5180 | 0.249000 | 0.45500 | 5.51e-05 | 1.67e-13 |
| Eukaryotic Translation Termination | 92 | 1.94e-12 | 9.74e-11 | 0.4890 | 0.228000 | 0.43300 | 1.56e-04 | 7.17e-13 |
| Mitotic Metaphase and Anaphase | 216 | 3.93e-10 | 1.20e-08 | 0.1560 | 0.145000 | -0.05750 | 2.40e-04 | 1.46e-01 |
| tRNA Aminoacylation | 42 | 1.01e-02 | 3.59e-02 | 0.1850 | -0.184000 | 0.01850 | 3.95e-02 | 8.36e-01 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 111 | 1.14e-09 | 2.98e-08 | 0.3480 | 0.124000 | 0.32500 | 2.40e-02 | 3.22e-09 |
| Mitotic Anaphase | 215 | 8.55e-10 | 2.40e-08 | 0.1530 | 0.142000 | -0.05810 | 3.53e-04 | 1.43e-01 |
| Thrombin signalling through proteinase activated receptors (PARs) | 23 | 6.70e-04 | 3.75e-03 | 0.5200 | 0.454000 | 0.25500 | 1.64e-04 | 3.45e-02 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 4.62e-04 | 2.81e-03 | 0.2900 | 0.079900 | 0.27800 | 3.24e-01 | 5.88e-04 |
| Cap-dependent Translation Initiation | 118 | 9.30e-10 | 2.51e-08 | 0.3370 | 0.118000 | 0.31600 | 2.68e-02 | 3.08e-09 |
| Eukaryotic Translation Initiation | 118 | 9.30e-10 | 2.51e-08 | 0.3370 | 0.118000 | 0.31600 | 2.68e-02 | 3.08e-09 |
| Processing of DNA double-strand break ends | 60 | 2.00e-03 | 8.90e-03 | 0.1790 | 0.178000 | -0.01950 | 1.73e-02 | 7.94e-01 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 68 | 1.05e-03 | 5.39e-03 | 0.1700 | 0.029400 | -0.16800 | 6.75e-01 | 1.69e-02 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 100 | 2.57e-13 | 1.63e-11 | 0.4930 | 0.236000 | 0.43300 | 4.58e-05 | 7.62e-14 |
| Scavenging by Class A Receptors | 16 | 9.33e-04 | 4.90e-03 | 0.6380 | 0.538000 | 0.34300 | 1.94e-04 | 1.76e-02 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 59 | 4.64e-04 | 2.81e-03 | 0.2530 | 0.052700 | 0.24700 | 4.84e-01 | 1.02e-03 |
| Telomere Maintenance | 69 | 7.84e-04 | 4.28e-03 | 0.1900 | 0.190000 | -0.00210 | 6.31e-03 | 9.76e-01 |
| Platelet homeostasis | 70 | 1.06e-03 | 5.39e-03 | 0.1760 | 0.016300 | -0.17500 | 8.14e-01 | 1.15e-02 |
| SARS-CoV-1 modulates host translation machinery | 36 | 1.74e-06 | 2.64e-05 | 0.5800 | 0.304000 | 0.49400 | 1.62e-03 | 2.95e-07 |
| Interconversion of nucleotide di- and triphosphates | 27 | 6.25e-03 | 2.43e-02 | 0.3640 | 0.335000 | 0.14500 | 2.62e-03 | 1.93e-01 |
| Ribosomal scanning and start codon recognition | 58 | 1.54e-03 | 7.18e-03 | 0.2180 | 0.027300 | 0.21700 | 7.20e-01 | 4.33e-03 |
| Regulation of ornithine decarboxylase (ODC) | 48 | 1.66e-05 | 1.95e-04 | 0.4260 | -0.192000 | -0.38000 | 2.12e-02 | 5.23e-06 |
| Activation of gene expression by SREBF (SREBP) | 42 | 1.07e-02 | 3.77e-02 | 0.2120 | -0.211000 | -0.02320 | 1.82e-02 | 7.95e-01 |
| Circadian Clock | 66 | 2.88e-03 | 1.21e-02 | 0.1530 | -0.148000 | 0.03980 | 3.83e-02 | 5.76e-01 |
| Translation initiation complex formation | 58 | 1.00e-03 | 5.25e-03 | 0.2400 | 0.048300 | 0.23500 | 5.25e-01 | 1.93e-03 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 72 | 4.50e-04 | 2.75e-03 | 0.2110 | -0.022800 | -0.21000 | 7.38e-01 | 2.10e-03 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 73 | 6.13e-04 | 3.52e-03 | 0.1970 | -0.011300 | -0.19700 | 8.67e-01 | 3.60e-03 |
| Mitochondrial calcium ion transport | 22 | 4.68e-05 | 4.46e-04 | 0.6590 | -0.550000 | -0.36400 | 8.07e-06 | 3.12e-03 |
| Signaling by Retinoic Acid | 35 | 9.46e-03 | 3.40e-02 | 0.2740 | -0.263000 | -0.07790 | 7.10e-03 | 4.25e-01 |
| Synthesis of DNA | 115 | 6.78e-05 | 5.78e-04 | 0.1480 | 0.040600 | -0.14200 | 4.52e-01 | 8.66e-03 |
| Protein localization | 154 | 1.82e-15 | 2.05e-13 | 0.4220 | -0.375000 | -0.19400 | 9.99e-16 | 3.29e-05 |
| Homology Directed Repair | 100 | 1.79e-05 | 2.04e-04 | 0.2290 | 0.225000 | 0.04440 | 1.04e-04 | 4.44e-01 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 94 | 2.75e-05 | 2.93e-04 | 0.2350 | 0.230000 | 0.04990 | 1.17e-04 | 4.04e-01 |
| DNA Replication | 126 | 2.82e-05 | 2.96e-04 | 0.1550 | 0.026000 | -0.15300 | 6.15e-01 | 3.03e-03 |
| Orc1 removal from chromatin | 67 | 3.72e-04 | 2.39e-03 | 0.2560 | -0.070600 | -0.24600 | 3.18e-01 | 4.93e-04 |
| The citric acid (TCA) cycle and respiratory electron transport | 160 | 1.53e-39 | 2.24e-36 | 0.7510 | -0.611000 | -0.43600 | 1.03e-40 | 1.79e-21 |
| Regulation of APC/C activators between G1/S and early anaphase | 78 | 6.26e-04 | 3.55e-03 | 0.2010 | -0.024400 | -0.19900 | 7.10e-01 | 2.39e-03 |
| Gap junction trafficking | 29 | 6.51e-03 | 2.49e-02 | 0.3590 | 0.326000 | 0.15100 | 2.40e-03 | 1.59e-01 |
| EPHB-mediated forward signaling | 40 | 3.09e-04 | 2.06e-03 | 0.4020 | 0.358000 | 0.18400 | 9.13e-05 | 4.45e-02 |
| Glycogen synthesis | 13 | 1.09e-03 | 5.50e-03 | 0.7250 | -0.592000 | -0.41900 | 2.22e-04 | 8.96e-03 |
| Mitotic Prometaphase | 185 | 3.57e-10 | 1.11e-08 | 0.2620 | 0.250000 | 0.07760 | 4.58e-09 | 6.90e-02 |
| HATs acetylate histones | 82 | 7.24e-05 | 6.01e-04 | 0.2580 | -0.247000 | -0.07470 | 1.12e-04 | 2.43e-01 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 70 | 7.24e-04 | 3.98e-03 | 0.2290 | -0.051400 | -0.22300 | 4.57e-01 | 1.26e-03 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 70 | 7.24e-04 | 3.98e-03 | 0.2290 | -0.051400 | -0.22300 | 4.57e-01 | 1.26e-03 |
| Post NMDA receptor activation events | 63 | 6.06e-03 | 2.36e-02 | 0.1660 | 0.005600 | -0.16600 | 9.39e-01 | 2.31e-02 |
| Citric acid cycle (TCA cycle) | 22 | 3.21e-09 | 7.33e-08 | 0.9670 | -0.764000 | -0.59300 | 5.42e-10 | 1.47e-06 |
| APC/C-mediated degradation of cell cycle proteins | 84 | 1.18e-03 | 5.81e-03 | 0.1650 | 0.004860 | -0.16500 | 9.39e-01 | 8.81e-03 |
| Regulation of mitotic cell cycle | 84 | 1.18e-03 | 5.81e-03 | 0.1650 | 0.004860 | -0.16500 | 9.39e-01 | 8.81e-03 |
| MET promotes cell motility | 39 | 1.74e-03 | 7.84e-03 | 0.3470 | 0.315000 | 0.14600 | 6.57e-04 | 1.16e-01 |
| Regulation of RAS by GAPs | 65 | 1.02e-03 | 5.30e-03 | 0.2380 | -0.061000 | -0.23000 | 3.96e-01 | 1.32e-03 |
| Binding and Uptake of Ligands by Scavenger Receptors | 32 | 1.36e-03 | 6.53e-03 | 0.4120 | 0.364000 | 0.19500 | 3.73e-04 | 5.68e-02 |
| MET activates PTK2 signaling | 29 | 6.10e-03 | 2.37e-02 | 0.3690 | 0.331000 | 0.16300 | 2.04e-03 | 1.30e-01 |
| Degradation of GLI1 by the proteasome | 57 | 3.96e-05 | 3.96e-04 | 0.3730 | -0.166000 | -0.33400 | 3.07e-02 | 1.32e-05 |
| Activation of kainate receptors upon glutamate binding | 21 | 2.71e-03 | 1.15e-02 | 0.5050 | 0.431000 | 0.26300 | 6.26e-04 | 3.70e-02 |
| PPARA activates gene expression | 106 | 3.31e-04 | 2.16e-03 | 0.1550 | -0.154000 | 0.01350 | 6.08e-03 | 8.11e-01 |
| RHOC GTPase cycle | 70 | 1.68e-04 | 1.23e-03 | 0.2820 | 0.265000 | 0.09800 | 1.31e-04 | 1.56e-01 |
| Cellular response to starvation | 148 | 1.74e-11 | 7.07e-10 | 0.3600 | 0.158000 | 0.32400 | 9.26e-04 | 1.11e-11 |
| Gap junction trafficking and regulation | 31 | 6.71e-03 | 2.55e-02 | 0.3500 | 0.316000 | 0.15100 | 2.35e-03 | 1.46e-01 |
| Hh mutants abrogate ligand secretion | 55 | 6.17e-04 | 3.52e-03 | 0.3040 | -0.116000 | -0.28100 | 1.37e-01 | 3.18e-04 |
| Regulation of lipid metabolism by PPARalpha | 108 | 4.12e-04 | 2.56e-03 | 0.1500 | -0.150000 | 0.01490 | 7.27e-03 | 7.90e-01 |
| Caspase activation via Death Receptors in the presence of ligand | 15 | 1.11e-02 | 3.87e-02 | 0.5280 | 0.446000 | 0.28300 | 2.77e-03 | 5.77e-02 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 46 | 8.58e-04 | 4.64e-03 | 0.3420 | -0.148000 | -0.30800 | 8.29e-02 | 3.00e-04 |
| RHO GTPase Effectors | 241 | 1.84e-14 | 1.58e-12 | 0.3060 | 0.281000 | 0.12100 | 6.27e-14 | 1.26e-03 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 48 | 1.16e-04 | 8.96e-04 | 0.3970 | -0.190000 | -0.34900 | 2.29e-02 | 2.93e-05 |
| Switching of origins to a post-replicative state | 87 | 7.99e-04 | 4.35e-03 | 0.1950 | -0.034300 | -0.19200 | 5.80e-01 | 1.95e-03 |
| Extra-nuclear estrogen signaling | 63 | 1.35e-02 | 4.56e-02 | 0.1520 | 0.151000 | -0.00604 | 3.78e-02 | 9.34e-01 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 49 | 3.90e-04 | 2.45e-03 | 0.3560 | -0.161000 | -0.31800 | 5.16e-02 | 1.20e-04 |
| p53-Independent DNA Damage Response | 49 | 3.90e-04 | 2.45e-03 | 0.3560 | -0.161000 | -0.31800 | 5.16e-02 | 1.20e-04 |
| p53-Independent G1/S DNA damage checkpoint | 49 | 3.90e-04 | 2.45e-03 | 0.3560 | -0.161000 | -0.31800 | 5.16e-02 | 1.20e-04 |
| Hedgehog ligand biogenesis | 60 | 1.16e-03 | 5.79e-03 | 0.2720 | -0.097500 | -0.25400 | 1.92e-01 | 6.80e-04 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 49 | 3.73e-04 | 2.39e-03 | 0.3590 | -0.164000 | -0.31900 | 4.78e-02 | 1.11e-04 |
| SCF-beta-TrCP mediated degradation of Emi1 | 53 | 1.59e-04 | 1.17e-03 | 0.3650 | -0.168000 | -0.32400 | 3.42e-02 | 4.56e-05 |
| Nuclear Receptor transcription pathway | 42 | 4.36e-03 | 1.74e-02 | 0.3050 | -0.279000 | -0.12400 | 1.76e-03 | 1.66e-01 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 12 | 3.61e-03 | 1.48e-02 | 0.6890 | 0.558000 | 0.40300 | 8.09e-04 | 1.56e-02 |
| Negative regulation of NOTCH4 signaling | 54 | 2.57e-04 | 1.75e-03 | 0.3470 | -0.156000 | -0.31000 | 4.82e-02 | 8.09e-05 |
| EPH-Ephrin signaling | 84 | 2.81e-05 | 2.96e-04 | 0.2990 | 0.274000 | 0.12000 | 1.48e-05 | 5.83e-02 |
| G alpha (q) signalling events | 122 | 3.61e-05 | 3.63e-04 | 0.2090 | 0.203000 | 0.05000 | 1.08e-04 | 3.41e-01 |
| SCF(Skp2)-mediated degradation of p27/p21 | 58 | 3.52e-03 | 1.45e-02 | 0.2430 | -0.078200 | -0.23000 | 3.03e-01 | 2.40e-03 |
| Respiratory electron transport | 93 | 1.09e-25 | 5.29e-23 | 0.8040 | -0.639000 | -0.48700 | 1.51e-26 | 4.64e-16 |
| Complex I biogenesis | 51 | 7.55e-16 | 9.18e-14 | 0.8470 | -0.670000 | -0.51900 | 1.19e-16 | 1.47e-10 |
| RHO GTPases Activate WASPs and WAVEs | 36 | 1.00e-05 | 1.25e-04 | 0.5570 | 0.462000 | 0.31100 | 1.61e-06 | 1.26e-03 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 33 | 3.06e-04 | 2.06e-03 | 0.4760 | 0.403000 | 0.25200 | 6.09e-05 | 1.22e-02 |
| S Phase | 155 | 2.25e-04 | 1.56e-03 | 0.1090 | 0.058400 | -0.09230 | 2.11e-01 | 4.76e-02 |
| Metabolism of polyamines | 56 | 8.97e-04 | 4.74e-03 | 0.3030 | -0.126000 | -0.27600 | 1.04e-01 | 3.56e-04 |
| VEGFR2 mediated cell proliferation | 19 | 5.20e-03 | 2.04e-02 | 0.5120 | 0.429000 | 0.27900 | 1.20e-03 | 3.53e-02 |
| Signaling by NOTCH4 | 81 | 2.23e-04 | 1.55e-03 | 0.2610 | -0.093700 | -0.24400 | 1.45e-01 | 1.51e-04 |
| CDK-mediated phosphorylation and removal of Cdc6 | 69 | 1.37e-03 | 6.56e-03 | 0.2430 | -0.079300 | -0.22900 | 2.55e-01 | 9.99e-04 |
| Formation of paraxial mesoderm | 62 | 8.80e-04 | 4.69e-03 | 0.2810 | -0.109000 | -0.25900 | 1.37e-01 | 4.21e-04 |
| Sensory Perception | 142 | 3.63e-04 | 2.34e-03 | 0.1200 | 0.034400 | -0.11500 | 4.80e-01 | 1.80e-02 |
| Glycogen metabolism | 24 | 3.48e-03 | 1.44e-02 | 0.4660 | -0.395000 | -0.24600 | 8.01e-04 | 3.67e-02 |
| DNA Replication Pre-Initiation | 102 | 2.69e-04 | 1.82e-03 | 0.2070 | -0.051200 | -0.20000 | 3.72e-01 | 4.82e-04 |
| Recycling pathway of L1 | 38 | 5.01e-05 | 4.63e-04 | 0.4950 | 0.416000 | 0.26800 | 8.90e-06 | 4.32e-03 |
| WNT5A-dependent internalization of FZD4 | 14 | 7.37e-03 | 2.75e-02 | 0.5890 | 0.336000 | 0.48400 | 2.94e-02 | 1.73e-03 |
| G1/S Transition | 124 | 8.67e-04 | 4.67e-03 | 0.1320 | 0.015500 | -0.13100 | 7.66e-01 | 1.18e-02 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 113 | 7.84e-30 | 5.72e-27 | 0.7880 | -0.626000 | -0.47900 | 1.21e-30 | 1.29e-18 |
| Factors involved in megakaryocyte development and platelet production | 113 | 1.41e-05 | 1.68e-04 | 0.2550 | 0.238000 | 0.09140 | 1.26e-05 | 9.36e-02 |
| Hh mutants are degraded by ERAD | 53 | 1.62e-03 | 7.52e-03 | 0.3000 | -0.126000 | -0.27200 | 1.13e-01 | 6.13e-04 |
| GLI3 is processed to GLI3R by the proteasome | 57 | 7.26e-05 | 6.01e-04 | 0.3770 | -0.184000 | -0.32900 | 1.64e-02 | 1.70e-05 |
| Ubiquitin-dependent degradation of Cyclin D | 50 | 5.20e-04 | 3.09e-03 | 0.3530 | -0.166000 | -0.31100 | 4.21e-02 | 1.41e-04 |
| G1/S DNA Damage Checkpoints | 62 | 2.15e-03 | 9.42e-03 | 0.2580 | -0.095200 | -0.23900 | 1.95e-01 | 1.12e-03 |
| Mitochondrial protein import | 63 | 1.78e-09 | 4.47e-08 | 0.5610 | -0.462000 | -0.31800 | 2.18e-10 | 1.25e-05 |
| HSF1-dependent transactivation | 33 | 2.74e-05 | 2.93e-04 | 0.5600 | -0.461000 | -0.31700 | 4.57e-06 | 1.62e-03 |
| DNA Double-Strand Break Repair | 130 | 3.19e-04 | 2.10e-03 | 0.1590 | 0.159000 | 0.01540 | 1.81e-03 | 7.61e-01 |
| Non-integrin membrane-ECM interactions | 55 | 1.07e-02 | 3.76e-02 | 0.2200 | 0.210000 | 0.06680 | 7.15e-03 | 3.92e-01 |
| Vif-mediated degradation of APOBEC3G | 52 | 2.14e-04 | 1.51e-03 | 0.3730 | -0.183000 | -0.32500 | 2.26e-02 | 5.04e-05 |
| Chromatin modifying enzymes | 202 | 6.86e-05 | 5.78e-04 | 0.1010 | -0.080800 | 0.06090 | 4.82e-02 | 1.37e-01 |
| Chromatin organization | 202 | 6.86e-05 | 5.78e-04 | 0.1010 | -0.080800 | 0.06090 | 4.82e-02 | 1.37e-01 |
| Ion homeostasis | 47 | 2.63e-05 | 2.87e-04 | 0.4570 | -0.245000 | -0.38600 | 3.70e-03 | 4.63e-06 |
| APC/C:Cdc20 mediated degradation of Securin | 66 | 1.25e-03 | 6.10e-03 | 0.2660 | -0.104000 | -0.24500 | 1.43e-01 | 5.75e-04 |
| Assembly of the pre-replicative complex | 88 | 6.41e-04 | 3.61e-03 | 0.2270 | -0.073800 | -0.21400 | 2.32e-01 | 5.17e-04 |
| Mitotic G1 phase and G1/S transition | 141 | 1.08e-03 | 5.50e-03 | 0.1110 | 0.034400 | -0.10500 | 4.82e-01 | 3.10e-02 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 70 | 1.00e-04 | 7.81e-04 | 0.3250 | -0.149000 | -0.28900 | 3.08e-02 | 2.91e-05 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 52 | 1.46e-04 | 1.11e-03 | 0.3860 | -0.194000 | -0.33300 | 1.56e-02 | 3.19e-05 |
| Degradation of GLI2 by the proteasome | 57 | 4.78e-05 | 4.50e-04 | 0.3930 | -0.199000 | -0.33900 | 9.38e-03 | 9.84e-06 |
| Diseases associated with N-glycosylation of proteins | 20 | 5.02e-06 | 6.78e-05 | 0.8020 | 0.633000 | 0.49400 | 9.63e-07 | 1.32e-04 |
| Metabolism of water-soluble vitamins and cofactors | 110 | 4.38e-03 | 1.74e-02 | 0.1180 | -0.115000 | 0.02350 | 3.69e-02 | 6.71e-01 |
| Downstream signaling events of B Cell Receptor (BCR) | 78 | 1.04e-03 | 5.36e-03 | 0.2400 | -0.085500 | -0.22400 | 1.92e-01 | 6.28e-04 |
| Hedgehog ‘on’ state | 82 | 8.75e-03 | 3.18e-02 | 0.1560 | -0.017500 | -0.15500 | 7.85e-01 | 1.56e-02 |
| Degradation of the extracellular matrix | 104 | 1.72e-06 | 2.64e-05 | 0.3220 | 0.286000 | 0.15000 | 4.92e-07 | 8.46e-03 |
| Vpu mediated degradation of CD4 | 50 | 2.22e-04 | 1.55e-03 | 0.3860 | -0.197000 | -0.33300 | 1.62e-02 | 4.74e-05 |
| p53-Dependent G1 DNA Damage Response | 61 | 2.10e-03 | 9.33e-03 | 0.2710 | -0.112000 | -0.24700 | 1.32e-01 | 8.34e-04 |
| p53-Dependent G1/S DNA damage checkpoint | 61 | 2.10e-03 | 9.33e-03 | 0.2710 | -0.112000 | -0.24700 | 1.32e-01 | 8.34e-04 |
| Formation of ATP by chemiosmotic coupling | 16 | 6.09e-05 | 5.36e-04 | 0.8010 | -0.630000 | -0.49500 | 1.27e-05 | 6.14e-04 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 53 | 5.84e-05 | 5.26e-04 | 0.4090 | -0.213000 | -0.34900 | 7.26e-03 | 1.12e-05 |
| Stabilization of p53 | 54 | 6.09e-04 | 3.51e-03 | 0.3380 | -0.162000 | -0.29700 | 4.00e-02 | 1.59e-04 |
| Activation of NMDA receptors and postsynaptic events | 74 | 1.23e-02 | 4.23e-02 | 0.1640 | -0.026700 | -0.16200 | 6.91e-01 | 1.59e-02 |
| Anti-inflammatory response favouring Leishmania parasite infection | 63 | 1.40e-03 | 6.65e-03 | 0.2790 | 0.253000 | 0.11700 | 5.24e-04 | 1.07e-01 |
| Leishmania parasite growth and survival | 63 | 1.40e-03 | 6.65e-03 | 0.2790 | 0.253000 | 0.11700 | 5.24e-04 | 1.07e-01 |
| Regulation of Apoptosis | 51 | 9.55e-05 | 7.49e-04 | 0.4060 | -0.212000 | -0.34600 | 8.98e-03 | 1.87e-05 |
| Regulation of RUNX3 expression and activity | 55 | 6.40e-03 | 2.46e-02 | 0.2570 | -0.104000 | -0.23500 | 1.83e-01 | 2.58e-03 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 64 | 1.39e-03 | 6.64e-03 | 0.2800 | -0.121000 | -0.25200 | 9.34e-02 | 4.81e-04 |
| Sensory processing of sound by inner hair cells of the cochlea | 46 | 1.18e-02 | 4.09e-02 | 0.2680 | 0.243000 | 0.11300 | 4.37e-03 | 1.86e-01 |
| Translation | 292 | 2.78e-06 | 3.98e-05 | 0.1160 | -0.115000 | 0.01470 | 7.48e-04 | 6.66e-01 |
| Dissolution of Fibrin Clot | 10 | 1.16e-03 | 5.79e-03 | 0.8510 | 0.663000 | 0.53300 | 2.85e-04 | 3.50e-03 |
| MAPK6/MAPK4 signaling | 83 | 2.11e-03 | 9.33e-03 | 0.2180 | -0.075600 | -0.20500 | 2.34e-01 | 1.28e-03 |
| Keratan sulfate degradation | 13 | 4.34e-04 | 2.67e-03 | 0.7960 | 0.495000 | 0.62300 | 2.00e-03 | 9.94e-05 |
| Syndecan interactions | 26 | 2.20e-06 | 3.28e-05 | 0.7260 | 0.574000 | 0.44600 | 4.09e-07 | 8.38e-05 |
| SRP-dependent cotranslational protein targeting to membrane | 111 | 1.45e-14 | 1.41e-12 | 0.5370 | 0.310000 | 0.43800 | 1.64e-08 | 1.47e-15 |
| Cell Cycle | 583 | 5.37e-13 | 3.13e-11 | 0.1440 | 0.143000 | 0.01550 | 3.95e-09 | 5.24e-01 |
| Neurotransmitter receptors and postsynaptic signal transmission | 138 | 4.81e-03 | 1.90e-02 | 0.0906 | 0.058800 | -0.06900 | 2.34e-01 | 1.62e-01 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 72 | 7.04e-03 | 2.67e-02 | 0.2060 | -0.067700 | -0.19500 | 3.21e-01 | 4.30e-03 |
| Class A/1 (Rhodopsin-like receptors) | 135 | 1.12e-03 | 5.66e-03 | 0.1480 | 0.147000 | 0.02030 | 3.23e-03 | 6.84e-01 |
| Influenza Viral RNA Transcription and Replication | 135 | 1.88e-08 | 3.60e-07 | 0.3390 | 0.168000 | 0.29400 | 7.50e-04 | 3.78e-09 |
| RHO GTPases Activate NADPH Oxidases | 21 | 2.15e-03 | 9.42e-03 | 0.5430 | 0.316000 | 0.44100 | 1.21e-02 | 4.62e-04 |
| Apoptosis | 161 | 8.92e-04 | 4.73e-03 | 0.1250 | -0.000227 | -0.12500 | 9.96e-01 | 6.32e-03 |
| Activation of NF-kappaB in B cells | 65 | 1.70e-03 | 7.72e-03 | 0.2770 | -0.124000 | -0.24800 | 8.43e-02 | 5.41e-04 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 53 | 2.58e-04 | 1.75e-03 | 0.3770 | -0.197000 | -0.32100 | 1.32e-02 | 5.23e-05 |
| RAC3 GTPase cycle | 87 | 6.17e-04 | 3.52e-03 | 0.2500 | 0.227000 | 0.10300 | 2.50e-04 | 9.67e-02 |
| Hemostasis | 472 | 2.52e-16 | 3.34e-14 | 0.2330 | 0.215000 | 0.09050 | 1.64e-15 | 7.94e-04 |
| G beta:gamma signalling through BTK | 12 | 6.46e-03 | 2.48e-02 | 0.6630 | 0.526000 | 0.40300 | 1.60e-03 | 1.57e-02 |
| Semaphorin interactions | 62 | 7.39e-03 | 2.75e-02 | 0.2390 | 0.218000 | 0.09690 | 2.95e-03 | 1.87e-01 |
| RHOA GTPase cycle | 142 | 8.49e-06 | 1.09e-04 | 0.2470 | 0.225000 | 0.10400 | 3.88e-06 | 3.32e-02 |
| Metabolism of amino acids and derivatives | 317 | 4.65e-06 | 6.40e-05 | 0.1170 | -0.117000 | 0.00131 | 3.46e-04 | 9.68e-01 |
| Programmed Cell Death | 188 | 1.04e-03 | 5.36e-03 | 0.1060 | 0.013200 | -0.10500 | 7.56e-01 | 1.33e-02 |
| Trafficking and processing of endosomal TLR | 12 | 4.73e-04 | 2.84e-03 | 0.8290 | 0.525000 | 0.64200 | 1.65e-03 | 1.18e-04 |
| Cell Cycle, Mitotic | 474 | 1.73e-09 | 4.43e-08 | 0.1390 | 0.137000 | 0.02020 | 3.31e-07 | 4.53e-01 |
| Fatty acid metabolism | 143 | 4.37e-05 | 4.23e-04 | 0.2230 | -0.205000 | -0.08820 | 2.36e-05 | 6.89e-02 |
| EPH-ephrin mediated repulsion of cells | 45 | 1.84e-04 | 1.32e-03 | 0.4320 | 0.357000 | 0.24300 | 3.37e-05 | 4.79e-03 |
| GPCR ligand binding | 186 | 5.23e-04 | 3.09e-03 | 0.1330 | 0.132000 | 0.01780 | 1.94e-03 | 6.77e-01 |
| Gastrulation | 85 | 8.24e-03 | 3.00e-02 | 0.1890 | -0.064200 | -0.17800 | 3.07e-01 | 4.66e-03 |
| Autophagy | 138 | 1.56e-04 | 1.16e-03 | 0.2100 | -0.194000 | -0.08020 | 8.74e-05 | 1.04e-01 |
| Macroautophagy | 123 | 1.59e-04 | 1.17e-03 | 0.2290 | -0.208000 | -0.09500 | 6.68e-05 | 6.92e-02 |
| M Phase | 341 | 2.78e-06 | 3.98e-05 | 0.1240 | 0.123000 | 0.01030 | 9.76e-05 | 7.45e-01 |
| COPI-dependent Golgi-to-ER retrograde traffic | 83 | 9.58e-10 | 2.54e-08 | 0.5050 | 0.409000 | 0.29700 | 1.24e-10 | 2.86e-06 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 72 | 2.01e-06 | 3.02e-05 | 0.4230 | 0.349000 | 0.23800 | 3.02e-07 | 4.76e-04 |
| Molecules associated with elastic fibres | 34 | 6.60e-04 | 3.70e-03 | 0.4650 | 0.379000 | 0.26900 | 1.31e-04 | 6.55e-03 |
| Signal amplification | 25 | 7.23e-03 | 2.73e-02 | 0.4430 | 0.363000 | 0.25400 | 1.69e-03 | 2.82e-02 |
| Rab regulation of trafficking | 115 | 6.27e-03 | 2.43e-02 | 0.1560 | 0.041500 | 0.15000 | 4.42e-01 | 5.50e-03 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 64 | 5.67e-05 | 5.17e-04 | 0.3830 | -0.211000 | -0.32000 | 3.49e-03 | 9.89e-06 |
| Selective autophagy | 70 | 3.39e-03 | 1.41e-02 | 0.2570 | -0.228000 | -0.12000 | 9.88e-04 | 8.32e-02 |
| NIK–>noncanonical NF-kB signaling | 57 | 6.05e-04 | 3.50e-03 | 0.3480 | -0.186000 | -0.29400 | 1.50e-02 | 1.23e-04 |
| Phase 0 - rapid depolarisation | 25 | 1.82e-05 | 2.05e-04 | 0.6830 | -0.426000 | -0.53300 | 2.25e-04 | 3.89e-06 |
| Platelet activation, signaling and aggregation | 218 | 3.05e-10 | 9.68e-09 | 0.2990 | 0.258000 | 0.15100 | 5.49e-11 | 1.26e-04 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 87 | 4.15e-03 | 1.66e-02 | 0.2150 | -0.088800 | -0.19600 | 1.53e-01 | 1.60e-03 |
| Intraflagellar transport | 48 | 7.44e-06 | 9.61e-05 | 0.5030 | 0.404000 | 0.29800 | 1.25e-06 | 3.47e-04 |
| Defective CFTR causes cystic fibrosis | 57 | 7.36e-03 | 2.75e-02 | 0.2700 | -0.130000 | -0.23600 | 8.88e-02 | 2.05e-03 |
| Interleukin-12 signaling | 40 | 2.12e-03 | 9.33e-03 | 0.3860 | 0.321000 | 0.21600 | 4.50e-04 | 1.84e-02 |
| Degradation of DVL | 55 | 1.76e-04 | 1.27e-03 | 0.3920 | -0.220000 | -0.32400 | 4.87e-03 | 3.20e-05 |
| Chondroitin sulfate biosynthesis | 15 | 1.23e-03 | 6.02e-03 | 0.6920 | 0.539000 | 0.43500 | 3.04e-04 | 3.57e-03 |
| Influenza Infection | 154 | 8.60e-08 | 1.53e-06 | 0.3100 | 0.161000 | 0.26500 | 5.53e-04 | 1.40e-08 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 85 | 4.64e-09 | 9.54e-08 | 0.4820 | 0.388000 | 0.28500 | 6.40e-10 | 5.46e-06 |
| Interleukin-1 signaling | 106 | 3.66e-03 | 1.50e-02 | 0.1950 | -0.078000 | -0.17800 | 1.66e-01 | 1.52e-03 |
| Degradation of AXIN | 53 | 5.78e-04 | 3.36e-03 | 0.3700 | -0.207000 | -0.30700 | 9.30e-03 | 1.13e-04 |
| Dectin-1 mediated noncanonical NF-kB signaling | 58 | 1.26e-03 | 6.11e-03 | 0.3290 | -0.178000 | -0.27700 | 1.93e-02 | 2.64e-04 |
| DARPP-32 events | 23 | 1.42e-02 | 4.76e-02 | 0.4320 | -0.351000 | -0.25200 | 3.56e-03 | 3.66e-02 |
| CS/DS degradation | 10 | 2.40e-03 | 1.02e-02 | 0.8110 | 0.621000 | 0.52100 | 6.78e-04 | 4.30e-03 |
| Interaction between L1 and Ankyrins | 24 | 1.19e-02 | 4.09e-02 | 0.4320 | -0.252000 | -0.35100 | 3.27e-02 | 2.93e-03 |
| FCGR3A-mediated phagocytosis | 57 | 4.52e-09 | 9.43e-08 | 0.5990 | 0.470000 | 0.37200 | 8.50e-10 | 1.22e-06 |
| Leishmania phagocytosis | 57 | 4.52e-09 | 9.43e-08 | 0.5990 | 0.470000 | 0.37200 | 8.50e-10 | 1.22e-06 |
| Parasite infection | 57 | 4.52e-09 | 9.43e-08 | 0.5990 | 0.470000 | 0.37200 | 8.50e-10 | 1.22e-06 |
| SARS-CoV-2 modulates host translation machinery | 49 | 7.13e-04 | 3.95e-03 | 0.3820 | 0.217000 | 0.31400 | 8.72e-03 | 1.41e-04 |
| Post-translational protein phosphorylation | 76 | 2.45e-09 | 5.77e-08 | 0.5230 | 0.415000 | 0.31800 | 3.85e-10 | 1.68e-06 |
| Regulation of RUNX2 expression and activity | 70 | 8.81e-04 | 4.69e-03 | 0.3050 | -0.161000 | -0.25800 | 1.96e-02 | 1.86e-04 |
| Cristae formation | 29 | 5.29e-06 | 7.01e-05 | 0.6720 | -0.521000 | -0.42400 | 1.21e-06 | 7.66e-05 |
| RAF/MAP kinase cascade | 232 | 5.25e-06 | 7.01e-05 | 0.1990 | -0.084100 | -0.18000 | 2.76e-02 | 2.34e-06 |
| RAC1 GTPase cycle | 174 | 9.30e-07 | 1.46e-05 | 0.2660 | 0.230000 | 0.13400 | 1.79e-07 | 2.27e-03 |
| MAPK1/MAPK3 signaling | 237 | 5.99e-06 | 7.88e-05 | 0.1970 | -0.084300 | -0.17800 | 2.56e-02 | 2.49e-06 |
| Assembly of collagen fibrils and other multimeric structures | 53 | 6.21e-05 | 5.43e-04 | 0.4330 | 0.349000 | 0.25700 | 1.13e-05 | 1.22e-03 |
| Signaling by Rho GTPases | 593 | 1.55e-12 | 8.06e-11 | 0.1890 | 0.171000 | 0.08080 | 1.46e-12 | 8.25e-04 |
| Mucopolysaccharidoses | 11 | 3.99e-04 | 2.49e-03 | 0.8840 | 0.669000 | 0.57900 | 1.23e-04 | 8.84e-04 |
| MAPK family signaling cascades | 272 | 1.69e-05 | 1.96e-04 | 0.1690 | -0.066300 | -0.15600 | 6.03e-02 | 1.01e-05 |
| Signaling by GPCR | 391 | 1.49e-05 | 1.77e-04 | 0.1260 | 0.122000 | 0.03380 | 3.90e-05 | 2.52e-01 |
| Nuclear events mediated by NFE2L2 | 76 | 5.03e-03 | 1.98e-02 | 0.2490 | -0.127000 | -0.21400 | 5.53e-02 | 1.25e-03 |
| FCGR activation | 10 | 1.56e-03 | 7.27e-03 | 0.8430 | 0.551000 | 0.63800 | 2.56e-03 | 4.80e-04 |
| The activation of arylsulfatases | 10 | 3.81e-03 | 1.55e-02 | 0.7810 | 0.594000 | 0.50700 | 1.15e-03 | 5.50e-03 |
| Collagen degradation | 50 | 2.41e-05 | 2.69e-04 | 0.4720 | 0.375000 | 0.28800 | 4.62e-06 | 4.28e-04 |
| Muscle contraction | 160 | 1.17e-13 | 8.11e-12 | 0.4410 | -0.266000 | -0.35200 | 6.93e-09 | 1.55e-14 |
| Interleukin-12 family signaling | 46 | 1.77e-03 | 7.94e-03 | 0.3730 | 0.303000 | 0.21700 | 3.74e-04 | 1.10e-02 |
| Elastic fibre formation | 41 | 1.22e-05 | 1.49e-04 | 0.5430 | 0.424000 | 0.33900 | 2.60e-06 | 1.74e-04 |
| Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 607 | 5.86e-12 | 2.44e-10 | 0.1850 | 0.166000 | 0.08140 | 3.73e-12 | 6.53e-04 |
| Regulation of expression of SLITs and ROBOs | 160 | 4.22e-03 | 1.69e-02 | 0.1520 | 0.057000 | 0.14100 | 2.14e-01 | 2.05e-03 |
| MHC class II antigen presentation | 94 | 2.37e-06 | 3.49e-05 | 0.3750 | 0.303000 | 0.22000 | 3.72e-07 | 2.32e-04 |
| UCH proteinases | 85 | 2.35e-03 | 1.01e-02 | 0.2560 | -0.135000 | -0.21800 | 3.13e-02 | 5.28e-04 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 80 | 2.82e-08 | 5.27e-07 | 0.4810 | 0.297000 | 0.37800 | 4.45e-06 | 5.16e-09 |
| VEGFA-VEGFR2 Pathway | 95 | 1.13e-03 | 5.67e-03 | 0.2580 | 0.218000 | 0.13800 | 2.38e-04 | 2.04e-02 |
| Metabolism | 1733 | 3.07e-14 | 2.35e-12 | 0.0936 | -0.092700 | -0.01320 | 2.66e-10 | 3.70e-01 |
| Asymmetric localization of PCP proteins | 61 | 2.36e-03 | 1.01e-02 | 0.3130 | -0.178000 | -0.25800 | 1.60e-02 | 5.04e-04 |
| Mitochondrial translation | 94 | 1.94e-18 | 4.05e-16 | 0.6900 | -0.526000 | -0.44600 | 1.24e-18 | 7.33e-14 |
| Mitochondrial translation termination | 88 | 8.79e-17 | 1.33e-14 | 0.6780 | -0.517000 | -0.43900 | 4.72e-17 | 1.14e-12 |
| Response to elevated platelet cytosolic Ca2+ | 112 | 8.29e-05 | 6.75e-04 | 0.2850 | 0.237000 | 0.15900 | 1.46e-05 | 3.77e-03 |
| Extracellular matrix organization | 242 | 5.58e-15 | 5.82e-13 | 0.3760 | 0.302000 | 0.22400 | 6.56e-16 | 2.16e-09 |
| Synthesis of substrates in N-glycan biosythesis | 58 | 5.73e-04 | 3.34e-03 | 0.3630 | 0.293000 | 0.21500 | 1.16e-04 | 4.57e-03 |
| GPCR downstream signalling | 352 | 9.44e-05 | 7.45e-04 | 0.1310 | 0.123000 | 0.04570 | 7.75e-05 | 1.42e-01 |
| Platelet degranulation | 108 | 4.48e-04 | 2.75e-03 | 0.2600 | 0.219000 | 0.14100 | 8.80e-05 | 1.13e-02 |
| Signaling by NOTCH | 173 | 1.11e-02 | 3.86e-02 | 0.1290 | -0.043700 | -0.12100 | 3.22e-01 | 6.12e-03 |
| Cell surface interactions at the vascular wall | 102 | 5.61e-05 | 5.15e-04 | 0.3090 | 0.254000 | 0.17700 | 9.69e-06 | 1.99e-03 |
| Integrin cell surface interactions | 73 | 1.34e-03 | 6.46e-03 | 0.3000 | 0.246000 | 0.17100 | 2.75e-04 | 1.15e-02 |
| Mitochondrial translation elongation | 88 | 3.30e-17 | 6.02e-15 | 0.6880 | -0.523000 | -0.44800 | 2.21e-17 | 3.85e-13 |
| IRE1alpha activates chaperones | 50 | 5.88e-05 | 5.26e-04 | 0.4550 | 0.283000 | 0.35700 | 5.46e-04 | 1.25e-05 |
| Golgi-to-ER retrograde transport | 116 | 2.93e-07 | 4.80e-06 | 0.3670 | 0.294000 | 0.22000 | 4.61e-08 | 4.38e-05 |
| Cardiac conduction | 96 | 3.67e-06 | 5.20e-05 | 0.3680 | -0.220000 | -0.29500 | 1.91e-04 | 6.20e-07 |
| Collagen formation | 78 | 2.99e-09 | 6.92e-08 | 0.5220 | 0.404000 | 0.33000 | 7.05e-10 | 4.64e-07 |
| Mitochondrial translation initiation | 88 | 9.09e-17 | 1.33e-14 | 0.6800 | -0.515000 | -0.44300 | 6.36e-17 | 6.65e-13 |
| Metabolism of lipids | 605 | 5.72e-04 | 3.34e-03 | 0.0558 | -0.052200 | 0.01980 | 2.93e-02 | 4.08e-01 |
| Sphingolipid metabolism | 73 | 7.31e-03 | 2.74e-02 | 0.2550 | 0.212000 | 0.14100 | 1.72e-03 | 3.79e-02 |
| XBP1(S) activates chaperone genes | 48 | 1.04e-04 | 8.07e-04 | 0.4520 | 0.282000 | 0.35300 | 7.16e-04 | 2.32e-05 |
| Retrograde neurotrophin signalling | 12 | 6.57e-03 | 2.51e-02 | 0.6780 | 0.443000 | 0.51300 | 7.83e-03 | 2.07e-03 |
| Mitochondrial biogenesis | 87 | 4.28e-09 | 9.33e-08 | 0.4900 | -0.379000 | -0.31000 | 1.02e-09 | 5.72e-07 |
| Transcriptional activation of mitochondrial biogenesis | 50 | 8.77e-03 | 3.18e-02 | 0.3110 | -0.251000 | -0.18300 | 2.12e-03 | 2.51e-02 |
| Leishmania infection | 144 | 3.78e-09 | 8.36e-08 | 0.3770 | 0.299000 | 0.23100 | 6.24e-10 | 1.78e-06 |
| Parasitic Infection Pathways | 144 | 3.78e-09 | 8.36e-08 | 0.3770 | 0.299000 | 0.23100 | 6.24e-10 | 1.78e-06 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 45 | 5.17e-04 | 3.08e-03 | 0.4240 | 0.264000 | 0.33100 | 2.21e-03 | 1.20e-04 |
| TP53 Regulates Metabolic Genes | 81 | 5.20e-03 | 2.04e-02 | 0.2520 | -0.209000 | -0.14200 | 1.18e-03 | 2.69e-02 |
| RAC2 GTPase cycle | 85 | 2.94e-03 | 1.23e-02 | 0.2610 | 0.214000 | 0.14900 | 6.40e-04 | 1.75e-02 |
| FCERI mediated NF-kB activation | 78 | 6.27e-04 | 3.55e-03 | 0.3120 | -0.186000 | -0.25100 | 4.58e-03 | 1.28e-04 |
| Lysosome Vesicle Biogenesis | 31 | 1.35e-02 | 4.56e-02 | 0.3830 | 0.302000 | 0.23700 | 3.65e-03 | 2.26e-02 |
| Regulation of PTEN stability and activity | 67 | 1.51e-04 | 1.13e-03 | 0.3740 | -0.232000 | -0.29300 | 1.02e-03 | 3.32e-05 |
| Negative regulation of MAPK pathway | 41 | 1.10e-02 | 3.85e-02 | 0.3400 | -0.208000 | -0.26900 | 2.11e-02 | 2.87e-03 |
| Anchoring of the basal body to the plasma membrane | 94 | 3.00e-03 | 1.26e-02 | 0.2490 | 0.203000 | 0.14300 | 6.56e-04 | 1.68e-02 |
| Chondroitin sulfate/dermatan sulfate metabolism | 41 | 7.85e-08 | 1.41e-06 | 0.6640 | 0.499000 | 0.43900 | 3.24e-08 | 1.17e-06 |
| Glycosaminoglycan metabolism | 103 | 7.08e-10 | 2.03e-08 | 0.4730 | 0.363000 | 0.30300 | 2.04e-10 | 1.09e-07 |
| DAP12 interactions | 32 | 3.18e-04 | 2.10e-03 | 0.5250 | 0.400000 | 0.34000 | 9.10e-05 | 8.63e-04 |
| Signaling by ROBO receptors | 199 | 1.12e-02 | 3.90e-02 | 0.1350 | 0.062100 | 0.12000 | 1.31e-01 | 3.51e-03 |
| Interleukin-4 and Interleukin-13 signaling | 83 | 4.87e-05 | 4.56e-04 | 0.3580 | 0.223000 | 0.28000 | 4.60e-04 | 1.05e-05 |
| Signaling by Receptor Tyrosine Kinases | 460 | 9.29e-05 | 7.41e-04 | 0.1270 | 0.114000 | 0.05660 | 3.04e-05 | 3.84e-02 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 41 | 3.17e-04 | 2.10e-03 | 0.4630 | 0.355000 | 0.29700 | 8.55e-05 | 9.86e-04 |
| RAF activation | 34 | 3.29e-03 | 1.37e-02 | 0.4270 | -0.272000 | -0.32900 | 6.06e-03 | 9.02e-04 |
| MTOR signalling | 41 | 2.94e-03 | 1.23e-02 | 0.3910 | -0.304000 | -0.24700 | 7.71e-04 | 6.19e-03 |
| CDC42 GTPase cycle | 147 | 4.71e-05 | 4.46e-04 | 0.2640 | 0.213000 | 0.15700 | 8.44e-06 | 1.05e-03 |
| Generic Transcription Pathway | 1076 | 1.36e-05 | 1.64e-04 | 0.0751 | -0.073100 | -0.01690 | 5.93e-05 | 3.53e-01 |
| Maturation of spike protein 9694548 | 37 | 1.56e-03 | 7.27e-03 | 0.4360 | 0.335000 | 0.27900 | 4.26e-04 | 3.33e-03 |
| SARS-CoV-2-host interactions | 175 | 2.16e-03 | 9.45e-03 | 0.1820 | 0.097500 | 0.15300 | 2.63e-02 | 4.74e-04 |
| Signal Transduction | 2006 | 2.46e-08 | 4.67e-07 | 0.0679 | 0.066800 | 0.01190 | 1.21e-06 | 3.88e-01 |
| Collagen biosynthesis and modifying enzymes | 58 | 1.88e-07 | 3.12e-06 | 0.5430 | 0.410000 | 0.35600 | 6.67e-08 | 2.83e-06 |
| Downstream TCR signaling | 79 | 1.68e-03 | 7.66e-03 | 0.2910 | -0.177000 | -0.23100 | 6.50e-03 | 3.81e-04 |
| ECM proteoglycans | 61 | 2.21e-03 | 9.61e-03 | 0.3270 | 0.256000 | 0.20300 | 5.43e-04 | 6.04e-03 |
| SARS-CoV-1 Infection | 135 | 4.21e-04 | 2.60e-03 | 0.2430 | 0.144000 | 0.19600 | 3.97e-03 | 8.33e-05 |
| Cilium Assembly | 183 | 5.41e-07 | 8.76e-06 | 0.2890 | 0.229000 | 0.17600 | 9.49e-08 | 3.94e-05 |
| Signaling by MET | 74 | 1.17e-02 | 4.07e-02 | 0.2490 | 0.200000 | 0.14900 | 2.96e-03 | 2.72e-02 |
| RHO GTPase cycle | 416 | 4.11e-06 | 5.71e-05 | 0.1690 | 0.142000 | 0.09120 | 6.68e-07 | 1.47e-03 |
| RNA Polymerase II Transcription | 1194 | 9.18e-05 | 7.36e-04 | 0.0613 | -0.060500 | -0.00951 | 4.87e-04 | 5.84e-01 |
| Cellular responses to stress | 687 | 4.01e-03 | 1.61e-02 | 0.0612 | 0.009420 | 0.06050 | 6.76e-01 | 7.23e-03 |
| Antimicrobial peptides | 20 | 6.68e-03 | 2.54e-02 | 0.5260 | 0.346000 | 0.39600 | 7.41e-03 | 2.18e-03 |
| SARS-CoV-1-host interactions | 93 | 6.10e-05 | 5.36e-04 | 0.3350 | 0.211000 | 0.26100 | 4.41e-04 | 1.40e-05 |
| Cellular responses to stimuli | 695 | 3.08e-03 | 1.28e-02 | 0.0661 | 0.014700 | 0.06450 | 5.10e-01 | 3.98e-03 |
| Regulation of actin dynamics for phagocytic cup formation | 59 | 1.36e-07 | 2.31e-06 | 0.5450 | 0.409000 | 0.36000 | 5.52e-08 | 1.76e-06 |
| Signaling by VEGF | 104 | 9.64e-03 | 3.45e-02 | 0.2130 | 0.173000 | 0.12400 | 2.33e-03 | 2.93e-02 |
| Gene expression (Transcription) | 1352 | 7.38e-05 | 6.09e-04 | 0.0585 | -0.057800 | -0.00897 | 4.24e-04 | 5.84e-01 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 23 | 1.46e-03 | 6.85e-03 | 0.5610 | 0.420000 | 0.37100 | 4.91e-04 | 2.04e-03 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 82 | 8.76e-09 | 1.75e-07 | 0.5000 | 0.377000 | 0.32900 | 3.63e-09 | 2.63e-07 |
| Diseases of signal transduction by growth factor receptors and second messengers | 391 | 1.20e-02 | 4.14e-02 | 0.0930 | -0.039400 | -0.08420 | 1.82e-01 | 4.39e-03 |
| Striated Muscle Contraction | 34 | 1.52e-08 | 2.95e-07 | 0.7690 | -0.565000 | -0.52200 | 1.16e-08 | 1.41e-07 |
| KEAP1-NFE2L2 pathway | 101 | 7.74e-03 | 2.86e-02 | 0.2260 | -0.139000 | -0.17800 | 1.62e-02 | 1.97e-03 |
| Cellular response to hypoxia | 72 | 3.29e-04 | 2.15e-03 | 0.3500 | -0.227000 | -0.26600 | 8.78e-04 | 9.46e-05 |
| ABC transporter disorders | 69 | 8.16e-03 | 2.99e-02 | 0.2740 | -0.174000 | -0.21300 | 1.27e-02 | 2.27e-03 |
| COPII-mediated vesicle transport | 63 | 1.39e-02 | 4.66e-02 | 0.2710 | 0.171000 | 0.21000 | 1.88e-02 | 3.99e-03 |
| Metabolism of carbohydrates | 251 | 1.13e-05 | 1.39e-04 | 0.2210 | 0.136000 | 0.17400 | 2.09e-04 | 2.25e-06 |
| Metal ion SLC transporters | 18 | 1.39e-04 | 1.05e-03 | 0.7430 | 0.507000 | 0.54300 | 1.97e-04 | 6.56e-05 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 29 | 2.28e-03 | 9.85e-03 | 0.4830 | -0.359000 | -0.32300 | 8.25e-04 | 2.57e-03 |
| Degradation of beta-catenin by the destruction complex | 83 | 8.73e-05 | 7.08e-04 | 0.3530 | -0.231000 | -0.26600 | 2.74e-04 | 2.74e-05 |
| Zinc transporters | 10 | 1.51e-04 | 1.13e-03 | 0.9930 | 0.685000 | 0.71900 | 1.77e-04 | 8.15e-05 |
| Calnexin/calreticulin cycle | 26 | 9.98e-03 | 3.56e-02 | 0.4440 | 0.297000 | 0.33000 | 8.85e-03 | 3.57e-03 |
| Ub-specific processing proteases | 155 | 2.39e-04 | 1.64e-03 | 0.2420 | -0.154000 | -0.18700 | 9.74e-04 | 5.96e-05 |
| SARS-CoV Infections | 370 | 7.43e-07 | 1.19e-05 | 0.2040 | 0.126000 | 0.16000 | 3.19e-05 | 1.46e-07 |
| G alpha (12/13) signalling events | 68 | 1.34e-02 | 4.55e-02 | 0.2630 | 0.202000 | 0.16900 | 4.03e-03 | 1.62e-02 |
| trans-Golgi Network Vesicle Budding | 68 | 3.90e-03 | 1.58e-02 | 0.3000 | 0.227000 | 0.19500 | 1.19e-03 | 5.39e-03 |
| Diseases associated with the TLR signaling cascade | 27 | 7.77e-03 | 2.86e-02 | 0.4480 | 0.300000 | 0.33200 | 6.96e-03 | 2.83e-03 |
| Diseases of Immune System | 27 | 7.77e-03 | 2.86e-02 | 0.4480 | 0.300000 | 0.33200 | 6.96e-03 | 2.83e-03 |
| p75 NTR receptor-mediated signalling | 91 | 3.81e-03 | 1.55e-02 | 0.2590 | 0.198000 | 0.16700 | 1.10e-03 | 6.04e-03 |
| Cytokine Signaling in Immune system | 570 | 7.11e-04 | 3.95e-03 | 0.1130 | 0.093700 | 0.06340 | 1.41e-04 | 1.01e-02 |
| Unfolded Protein Response (UPR) | 90 | 2.59e-05 | 2.84e-04 | 0.3620 | 0.241000 | 0.26900 | 7.65e-05 | 1.00e-05 |
| SARS-CoV-2 Infection | 263 | 2.06e-04 | 1.46e-03 | 0.1880 | 0.118000 | 0.14600 | 1.02e-03 | 4.84e-05 |
| Nervous system development | 501 | 1.02e-03 | 5.30e-03 | 0.1190 | 0.097200 | 0.06930 | 2.08e-04 | 8.17e-03 |
| GPVI-mediated activation cascade | 31 | 5.29e-04 | 3.11e-03 | 0.5220 | 0.355000 | 0.38300 | 6.26e-04 | 2.28e-04 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 13 | 1.32e-02 | 4.50e-02 | 0.6110 | 0.418000 | 0.44500 | 9.02e-03 | 5.50e-03 |
| Diseases of glycosylation | 124 | 1.51e-08 | 2.95e-07 | 0.4040 | 0.298000 | 0.27200 | 1.03e-08 | 1.65e-07 |
| Cardiogenesis | 19 | 3.94e-03 | 1.59e-02 | 0.5710 | -0.391000 | -0.41600 | 3.15e-03 | 1.68e-03 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 180 | 2.47e-05 | 2.73e-04 | 0.2560 | 0.168000 | 0.19300 | 1.01e-04 | 8.05e-06 |
| Signaling by Interleukins | 369 | 7.26e-03 | 2.74e-02 | 0.1190 | 0.095100 | 0.07110 | 1.77e-03 | 1.93e-02 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 182 | 1.08e-07 | 1.87e-06 | 0.3140 | 0.234000 | 0.21000 | 5.46e-08 | 1.03e-06 |
| Viral Infection Pathways | 649 | 2.64e-06 | 3.85e-05 | 0.1480 | 0.092600 | 0.11600 | 6.21e-05 | 5.52e-07 |
| Antigen processing: Ubiquitination & Proteasome degradation | 292 | 9.38e-08 | 1.65e-06 | 0.2500 | -0.187000 | -0.16500 | 3.85e-08 | 1.34e-06 |
| SLC-mediated transmembrane transport | 158 | 1.65e-03 | 7.59e-03 | 0.2120 | 0.139000 | 0.16000 | 2.56e-03 | 5.18e-04 |
| Axon guidance | 481 | 1.17e-03 | 5.81e-03 | 0.1240 | 0.097200 | 0.07660 | 2.75e-04 | 4.13e-03 |
| ER to Golgi Anterograde Transport | 138 | 6.51e-05 | 5.65e-04 | 0.2800 | 0.187000 | 0.20800 | 1.48e-04 | 2.55e-05 |
| TCF dependent signaling in response to WNT | 159 | 1.99e-04 | 1.42e-03 | 0.2450 | -0.183000 | -0.16300 | 7.02e-05 | 4.06e-04 |
| rRNA processing in the nucleus and cytosol | 190 | 4.45e-05 | 4.27e-04 | 0.2440 | 0.164000 | 0.18000 | 1.02e-04 | 1.84e-05 |
| Glycosphingolipid metabolism | 36 | 1.04e-02 | 3.67e-02 | 0.3770 | 0.259000 | 0.27400 | 7.08e-03 | 4.45e-03 |
| G beta:gamma signalling through PI3Kgamma | 19 | 4.10e-03 | 1.65e-02 | 0.5700 | 0.410000 | 0.39600 | 1.97e-03 | 2.80e-03 |
| Innate Immune System | 828 | 2.08e-22 | 6.06e-20 | 0.2660 | 0.195000 | 0.18100 | 2.90e-21 | 1.19e-18 |
| MAP kinase activation | 63 | 1.00e-02 | 3.57e-02 | 0.2860 | -0.196000 | -0.20900 | 7.18e-03 | 4.14e-03 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 27 | 1.31e-02 | 4.45e-02 | 0.4250 | 0.294000 | 0.30700 | 8.22e-03 | 5.79e-03 |
| ABC-family proteins mediated transport | 92 | 1.19e-03 | 5.83e-03 | 0.2870 | -0.196000 | -0.20900 | 1.14e-03 | 5.26e-04 |
| Asparagine N-linked glycosylation | 275 | 4.46e-12 | 1.97e-10 | 0.3290 | 0.239000 | 0.22700 | 1.07e-11 | 1.09e-10 |
| Class I peroxisomal membrane protein import | 20 | 1.35e-02 | 4.56e-02 | 0.4920 | -0.353000 | -0.34200 | 6.21e-03 | 8.16e-03 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 10 | 1.73e-04 | 1.26e-03 | 0.9870 | -0.703000 | -0.69200 | 1.17e-04 | 1.51e-04 |
| Infectious disease | 813 | 4.24e-11 | 1.55e-09 | 0.1860 | 0.126000 | 0.13700 | 1.45e-09 | 4.70e-11 |
| rRNA processing | 200 | 3.91e-04 | 2.45e-03 | 0.2110 | 0.144000 | 0.15400 | 4.71e-04 | 1.75e-04 |
| COPI-mediated anterograde transport | 89 | 8.37e-04 | 4.54e-03 | 0.3000 | 0.217000 | 0.20700 | 4.10e-04 | 7.57e-04 |
| Transport to the Golgi and subsequent modification | 163 | 4.94e-05 | 4.59e-04 | 0.2620 | 0.180000 | 0.19000 | 7.15e-05 | 2.79e-05 |
| Vesicle-mediated transport | 592 | 4.02e-08 | 7.42e-07 | 0.1830 | 0.134000 | 0.12500 | 3.30e-08 | 2.51e-07 |
| Deubiquitination | 226 | 1.42e-03 | 6.70e-03 | 0.1820 | -0.125000 | -0.13200 | 1.23e-03 | 6.60e-04 |
| G-protein beta:gamma signalling | 26 | 8.92e-03 | 3.22e-02 | 0.4520 | 0.323000 | 0.31700 | 4.42e-03 | 5.22e-03 |
| Diseases of metabolism | 203 | 6.70e-05 | 5.75e-04 | 0.2320 | 0.161000 | 0.16700 | 7.80e-05 | 4.27e-05 |
| Neutrophil degranulation | 399 | 1.14e-21 | 2.78e-19 | 0.3730 | 0.266000 | 0.26100 | 8.26e-20 | 4.97e-19 |
| Post-translational protein modification | 1183 | 1.26e-02 | 4.31e-02 | 0.0664 | 0.049700 | 0.04410 | 4.37e-03 | 1.14e-02 |
| Interleukin-10 signaling | 29 | 1.06e-05 | 1.31e-04 | 0.6670 | 0.469000 | 0.47400 | 1.22e-05 | 1.01e-05 |
| Immune System | 1574 | 6.93e-23 | 2.53e-20 | 0.2010 | 0.144000 | 0.14000 | 6.17e-21 | 5.72e-20 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 17 | 1.22e-02 | 4.19e-02 | 0.5400 | 0.381000 | 0.38300 | 6.55e-03 | 6.29e-03 |
| Disease | 1447 | 2.39e-12 | 1.12e-10 | 0.1510 | 0.108000 | 0.10600 | 1.26e-11 | 2.82e-11 |
| Diseases associated with glycosaminoglycan metabolism | 37 | 2.02e-05 | 2.27e-04 | 0.5730 | 0.406000 | 0.40500 | 1.91e-05 | 2.03e-05 |
| Neddylation | 233 | 1.94e-09 | 4.73e-08 | 0.3130 | -0.222000 | -0.22100 | 5.64e-09 | 6.56e-09 |
| Membrane Trafficking | 563 | 7.57e-07 | 1.20e-05 | 0.1710 | 0.121000 | 0.12000 | 1.05e-06 | 1.14e-06 |
Detailed Gene set reports
Expression and translocation of olfactory receptors
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 7.22e-11 |
| p.adjustMANOVA | 2.57e-09 |
| s.dist | 0.806 |
| s.intact | -0.245 |
| s.torn | -0.769 |
| p.intact | 0.0524 |
| p.torn | 1.07e-09 |
| Gene | intact | torn |
|---|---|---|
| REEP1 | -7892 | -7869 |
| OR56A1 | -4598 | -8150 |
| OR7C1 | -3963 | -7836 |
| OR1D2 | -3276 | -8377 |
| OR6Y1 | -3454 | -7927 |
| OR5AN1 | -3569 | -7562 |
| OR4D9 | -3507 | -7035 |
| OR10H5 | -4593 | -4808 |
| OR8A1 | -3217 | -6765 |
| OR10G3 | -2034 | -8266 |
| OR2AT4 | -1806 | -8172 |
| OR5A2 | -2543 | -5585 |
| OR5A1 | -1748 | -7864 |
| OR2M3 | -1672 | -8155 |
| OR6C75 | -1291 | -7862 |
| OR5AS1 | -1059 | -6136 |
| OR14J1 | -984 | -6531 |
| OR52K1 | -449 | -6832 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| EBF1 | 2056 | -4233 |
| LDB1 | -4293 | 4017 |
| OR10G3 | -2034 | -8266 |
| OR10H5 | -4593 | -4808 |
| OR14J1 | -984 | -6531 |
| OR1D2 | -3276 | -8377 |
| OR1I1 | 788 | -4700 |
| OR2AT4 | -1806 | -8172 |
| OR2M3 | -1672 | -8155 |
| OR4D9 | -3507 | -7035 |
| OR52K1 | -449 | -6832 |
| OR56A1 | -4598 | -8150 |
| OR5A1 | -1748 | -7864 |
| OR5A2 | -2543 | -5585 |
| OR5AN1 | -3569 | -7562 |
| OR5AS1 | -1059 | -6136 |
| OR6C75 | -1291 | -7862 |
| OR6Y1 | -3454 | -7927 |
| OR7C1 | -3963 | -7836 |
| OR8A1 | -3217 | -6765 |
| REEP1 | -7892 | -7869 |
Olfactory Signaling Pathway
| metric | value |
|---|---|
| setSize | 25 |
| pMANOVA | 1e-10 |
| p.adjustMANOVA | 3.47e-09 |
| s.dist | 0.723 |
| s.intact | -0.208 |
| s.torn | -0.692 |
| p.intact | 0.0723 |
| p.torn | 2.04e-09 |
| Gene | intact | torn |
|---|---|---|
| REEP1 | -7892 | -7869 |
| OR56A1 | -4598 | -8150 |
| ANO2 | -4520 | -8111 |
| GNAL | -7322 | -4553 |
| OR7C1 | -3963 | -7836 |
| OR1D2 | -3276 | -8377 |
| OR6Y1 | -3454 | -7927 |
| OR5AN1 | -3569 | -7562 |
| OR4D9 | -3507 | -7035 |
| OR10H5 | -4593 | -4808 |
| OR8A1 | -3217 | -6765 |
| OR10G3 | -2034 | -8266 |
| OR2AT4 | -1806 | -8172 |
| OR5A2 | -2543 | -5585 |
| OR5A1 | -1748 | -7864 |
| OR2M3 | -1672 | -8155 |
| OR6C75 | -1291 | -7862 |
| OR5AS1 | -1059 | -6136 |
| OR14J1 | -984 | -6531 |
| OR52K1 | -449 | -6832 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ADCY3 | 2429 | -4521 |
| ANO2 | -4520 | -8111 |
| EBF1 | 2056 | -4233 |
| GNAL | -7322 | -4553 |
| GNB1 | 6751 | 6564 |
| LDB1 | -4293 | 4017 |
| OR10G3 | -2034 | -8266 |
| OR10H5 | -4593 | -4808 |
| OR14J1 | -984 | -6531 |
| OR1D2 | -3276 | -8377 |
| OR1I1 | 788 | -4700 |
| OR2AT4 | -1806 | -8172 |
| OR2M3 | -1672 | -8155 |
| OR4D9 | -3507 | -7035 |
| OR52K1 | -449 | -6832 |
| OR56A1 | -4598 | -8150 |
| OR5A1 | -1748 | -7864 |
| OR5A2 | -2543 | -5585 |
| OR5AN1 | -3569 | -7562 |
| OR5AS1 | -1059 | -6136 |
| OR6C75 | -1291 | -7862 |
| OR6Y1 | -3454 | -7927 |
| OR7C1 | -3963 | -7836 |
| OR8A1 | -3217 | -6765 |
| REEP1 | -7892 | -7869 |
Regulation of FOXO transcriptional activity by acetylation
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00166 |
| p.adjustMANOVA | 0.00764 |
| s.dist | 0.491 |
| s.intact | -0.49 |
| s.torn | -0.0218 |
| p.intact | 0.00728 |
| p.torn | 0.905 |
| Gene | intact | torn |
|---|---|---|
| FOXO4 | -8202 | -5838 |
| KAT2B | -7899 | -5985 |
| TXNIP | -8046 | -2583 |
| SIRT1 | -6000 | -2494 |
| CREBBP | -6520 | -702 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| CREBBP | -6520 | -702 |
| EP300 | -4834 | 5238 |
| FOXO1 | 2382 | 383 |
| FOXO3 | -7289 | 593 |
| FOXO4 | -8202 | -5838 |
| KAT2B | -7899 | -5985 |
| SIRT1 | -6000 | -2494 |
| SIRT3 | -6273 | 2085 |
| TXN | 7527 | 4557 |
| TXNIP | -8046 | -2583 |
Beta-oxidation of very long chain fatty acids
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00168 |
| p.adjustMANOVA | 0.00766 |
| s.dist | 0.519 |
| s.intact | -0.515 |
| s.torn | -0.0618 |
| p.intact | 0.00478 |
| p.torn | 0.735 |
| Gene | intact | torn |
|---|---|---|
| ECI2 | -7768 | -5040 |
| DECR2 | -6361 | -4811 |
| MLYCD | -8024 | -3471 |
| ACOX1 | -7138 | -3096 |
| EHHADH | -4705 | -3446 |
| HSD17B4 | -3802 | -1119 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ABCD1 | -3927 | 2833 |
| ACAA1 | -4993 | 809 |
| ACOT4 | 6411 | 6875 |
| ACOT8 | -6885 | 2486 |
| ACOX1 | -7138 | -3096 |
| DECR2 | -6361 | -4811 |
| ECI2 | -7768 | -5040 |
| EHHADH | -4705 | -3446 |
| HSD17B4 | -3802 | -1119 |
| MLYCD | -8024 | -3471 |
HDMs demethylate histones
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 1.7e-05 |
| p.adjustMANOVA | 0.000196 |
| s.dist | 0.384 |
| s.intact | -0.0725 |
| s.torn | 0.377 |
| p.intact | 0.565 |
| p.torn | 0.00279 |
| Gene | intact | torn |
|---|---|---|
| KDM4B | -6845 | 5448 |
| KDM6B | -4236 | 5615 |
| KDM5C | -5832 | 4013 |
| KDM1A | -2102 | 6915 |
| JMJD6 | -2181 | 4952 |
| PHF2 | -5653 | 1337 |
| PHF8 | -5242 | 1128 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ARID5B | -6770 | -1301 |
| JMJD6 | -2181 | 4952 |
| KDM1A | -2102 | 6915 |
| KDM1B | 1974 | -1264 |
| KDM2A | 317 | 6362 |
| KDM2B | 2113 | 5948 |
| KDM3A | 2160 | 4619 |
| KDM3B | -7264 | -3490 |
| KDM4A | -1966 | -1180 |
| KDM4B | -6845 | 5448 |
| KDM4C | 6535 | 5421 |
| KDM5A | 4120 | 2366 |
| KDM5B | 6065 | 6326 |
| KDM5C | -5832 | 4013 |
| KDM5D | 4140 | 2830 |
| KDM6A | 2042 | -1221 |
| KDM6B | -4236 | 5615 |
| KDM7A | 489 | 5690 |
| PHF2 | -5653 | 1337 |
| PHF8 | -5242 | 1128 |
| UTY | -5790 | -2837 |
FOXO-mediated transcription of cell death genes
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.000205 |
| p.adjustMANOVA | 0.00146 |
| s.dist | 0.488 |
| s.intact | -0.485 |
| s.torn | -0.0574 |
| p.intact | 0.00116 |
| p.torn | 0.701 |
| Gene | intact | torn |
|---|---|---|
| NFYB | -6929 | -7224 |
| FOXO4 | -8202 | -5838 |
| PINK1 | -7568 | -5825 |
| STK11 | -7147 | -5634 |
| NFYC | -7114 | -4222 |
| BCL2L11 | -6323 | -2999 |
| CITED2 | -7901 | -1469 |
| CREBBP | -6520 | -702 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| BBC3 | 6920 | 6402 |
| BCL2L11 | -6323 | -2999 |
| BCL6 | -8326 | 651 |
| CITED2 | -7901 | -1469 |
| CREBBP | -6520 | -702 |
| DDIT3 | -1483 | 4753 |
| EP300 | -4834 | 5238 |
| FOXO1 | 2382 | 383 |
| FOXO3 | -7289 | 593 |
| FOXO4 | -8202 | -5838 |
| NFYA | 3285 | 4461 |
| NFYB | -6929 | -7224 |
| NFYC | -7114 | -4222 |
| PINK1 | -7568 | -5825 |
| STK11 | -7147 | -5634 |
cGMP effects
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.000361 |
| p.adjustMANOVA | 0.00234 |
| s.dist | 0.498 |
| s.intact | -0.0712 |
| s.torn | -0.493 |
| p.intact | 0.644 |
| p.torn | 0.0014 |
| Gene | intact | torn |
|---|---|---|
| PRKG1 | -8079 | -7881 |
| PDE5A | -4008 | -8375 |
| PDE2A | -4372 | -7510 |
| PDE9A | -3662 | -7829 |
| KCNMB4 | -3545 | -6565 |
| PDE11A | -8037 | -2696 |
| IRAG1 | -2388 | -8239 |
| KCNMB3 | -3021 | -5531 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| IRAG1 | -2388 | -8239 |
| ITPR1 | 3943 | -348 |
| KCNMA1 | 3864 | 1838 |
| KCNMB1 | 4005 | -2159 |
| KCNMB3 | -3021 | -5531 |
| KCNMB4 | -3545 | -6565 |
| PDE10A | 2889 | -5644 |
| PDE11A | -8037 | -2696 |
| PDE1A | 2724 | -1231 |
| PDE1B | 3877 | 2195 |
| PDE2A | -4372 | -7510 |
| PDE5A | -4008 | -8375 |
| PDE9A | -3662 | -7829 |
| PRKG1 | -8079 | -7881 |
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00469 |
| p.adjustMANOVA | 0.0186 |
| s.dist | 0.424 |
| s.intact | 0.424 |
| s.torn | 0.0126 |
| p.intact | 0.015 |
| p.torn | 0.942 |
| Gene | intact | torn |
|---|---|---|
| YWHAH | 6828 | 5058 |
| YWHAQ | 7344 | 4162 |
| CHEK2 | 2972 | 6151 |
| YWHAZ | 6662 | 2100 |
| CHEK1 | 6736 | 1734 |
| CCNB1 | 7195 | 7 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| CCNB1 | 7195 | 7 |
| CDK1 | 7480 | -1802 |
| CHEK1 | 6736 | 1734 |
| CHEK2 | 2972 | 6151 |
| WEE1 | -7132 | -7879 |
| YWHAB | 6520 | -1084 |
| YWHAE | -5956 | -4627 |
| YWHAG | -7075 | -5983 |
| YWHAH | 6828 | 5058 |
| YWHAQ | 7344 | 4162 |
| YWHAZ | 6662 | 2100 |
Signaling by Leptin
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00173 |
| p.adjustMANOVA | 0.00782 |
| s.dist | 0.533 |
| s.intact | -0.521 |
| s.torn | -0.112 |
| p.intact | 0.00276 |
| p.torn | 0.52 |
| Gene | intact | torn |
|---|---|---|
| JAK2 | -5156 | -5503 |
| STAT5B | -7976 | -3201 |
| IRS2 | -8076 | -2867 |
| LEPR | -5521 | -3668 |
| IRS1 | -8027 | -2498 |
| LEP | -7452 | -2187 |
| PTPN11 | -4966 | -3042 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| IRS1 | -8027 | -2498 |
| IRS2 | -8076 | -2867 |
| JAK2 | -5156 | -5503 |
| LEP | -7452 | -2187 |
| LEPR | -5521 | -3668 |
| PTPN11 | -4966 | -3042 |
| SH2B1 | -4667 | 2254 |
| SOCS3 | 3581 | 3687 |
| STAT3 | -6924 | 2338 |
| STAT5A | 2743 | 1450 |
| STAT5B | -7976 | -3201 |
RHO GTPases activate CIT
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 0.00164 |
| p.adjustMANOVA | 0.00759 |
| s.dist | 0.272 |
| s.intact | 0.233 |
| s.torn | -0.141 |
| p.intact | 0.0786 |
| p.torn | 0.288 |
| Gene | intact | torn |
|---|---|---|
| MYL9 | 2237 | -6028 |
| MYL12B | 5657 | -1588 |
| MYH9 | 1969 | -2432 |
| CIT | 6858 | -613 |
| PPP1R12A | 225 | -5500 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| CDKN1B | -8121 | -6477 |
| CIT | 6858 | -613 |
| DLG4 | 4882 | 7449 |
| KIF14 | 6893 | 2029 |
| MYH10 | -4274 | 34 |
| MYH11 | -1694 | -8369 |
| MYH14 | -8604 | -6578 |
| MYH9 | 1969 | -2432 |
| MYL12B | 5657 | -1588 |
| MYL6 | 6776 | 3637 |
| MYL9 | 2237 | -6028 |
| PPP1CB | -6609 | -6787 |
| PPP1R12A | 225 | -5500 |
| PPP1R12B | -7467 | -7943 |
| PRC1 | 7266 | 4470 |
| RAC1 | 6497 | 542 |
| RHOA | 6486 | 2625 |
| RHOB | -928 | -1083 |
| RHOC | 7217 | 5303 |
Branched-chain amino acid catabolism
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 1.21e-07 |
| p.adjustMANOVA | 2.07e-06 |
| s.dist | 0.759 |
| s.intact | -0.684 |
| s.torn | -0.328 |
| p.intact | 5.6e-08 |
| p.torn | 0.00918 |
| Gene | intact | torn |
|---|---|---|
| ACADSB | -8090 | -6019 |
| PPM1K | -8015 | -6030 |
| MCCC2 | -7807 | -5553 |
| DLD | -7856 | -5437 |
| IVD | -7427 | -5367 |
| ACAT1 | -8167 | -4549 |
| HIBADH | -7860 | -4289 |
| AUH | -7002 | -4580 |
| ALDH6A1 | -8110 | -3914 |
| ECHS1 | -7315 | -4209 |
| DBT | -7055 | -4219 |
| HIBCH | -7169 | -3645 |
| BCKDHA | -6282 | -2742 |
| ACAD8 | -6746 | -2334 |
| SLC25A44 | -4384 | -2812 |
| BCKDHB | -6549 | -1877 |
| MCCC1 | -6732 | -1152 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ACAD8 | -6746 | -2334 |
| ACADSB | -8090 | -6019 |
| ACAT1 | -8167 | -4549 |
| ALDH6A1 | -8110 | -3914 |
| AUH | -7002 | -4580 |
| BCAT1 | 7081 | 7401 |
| BCAT2 | -6728 | 214 |
| BCKDHA | -6282 | -2742 |
| BCKDHB | -6549 | -1877 |
| BCKDK | -5962 | 2224 |
| DBT | -7055 | -4219 |
| DLD | -7856 | -5437 |
| ECHS1 | -7315 | -4209 |
| HIBADH | -7860 | -4289 |
| HIBCH | -7169 | -3645 |
| HSD17B10 | 434 | -3097 |
| IVD | -7427 | -5367 |
| MCCC1 | -6732 | -1152 |
| MCCC2 | -7807 | -5553 |
| PPM1K | -8015 | -6030 |
| SLC25A44 | -4384 | -2812 |
Deposition of new CENPA-containing nucleosomes at the centromere
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 3.06e-05 |
| p.adjustMANOVA | 0.000317 |
| s.dist | 0.348 |
| s.intact | 0.348 |
| s.torn | -0.00285 |
| p.intact | 0.00097 |
| p.torn | 0.978 |
| Gene | intact | torn |
|---|---|---|
| CENPM | 3434 | -7221 |
| CENPC | 5886 | -3995 |
| MIS18BP1 | 5086 | -1913 |
| CENPH | 2630 | -2732 |
| RUVBL1 | 2593 | -2291 |
| CENPN | 7025 | -552 |
| RSF1 | 2887 | -1132 |
| H2AC18 | 2185 | -29 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| CENPC | 5886 | -3995 |
| CENPH | 2630 | -2732 |
| CENPI | 4264 | 2186 |
| CENPK | 6942 | 2669 |
| CENPL | -73 | 4510 |
| CENPM | 3434 | -7221 |
| CENPN | 7025 | -552 |
| CENPO | 5044 | 1367 |
| CENPP | 3967 | 1210 |
| CENPQ | -900 | -5156 |
| CENPT | 5987 | 6782 |
| CENPU | 7143 | 3041 |
| CENPW | 5443 | 4580 |
| H2AC18 | 2185 | -29 |
| H2AC6 | -8239 | -7392 |
| H2AJ | 5204 | 5176 |
| H2AZ2 | -2563 | -3313 |
| H2BC12 | -1828 | -2886 |
| H2BC21 | -8428 | -7833 |
| HJURP | 7460 | 3752 |
| ITGB3BP | 6446 | 4864 |
| KNL1 | 3670 | 923 |
| MIS18A | 3155 | 2665 |
| MIS18BP1 | 5086 | -1913 |
| NPM1 | 3762 | 5803 |
| RBBP4 | -4923 | -2598 |
| RBBP7 | -5511 | -5492 |
| RSF1 | 2887 | -1132 |
| RUVBL1 | 2593 | -2291 |
| SMARCA5 | -47 | -4639 |
Nucleosome assembly
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 3.06e-05 |
| p.adjustMANOVA | 0.000317 |
| s.dist | 0.348 |
| s.intact | 0.348 |
| s.torn | -0.00285 |
| p.intact | 0.00097 |
| p.torn | 0.978 |
| Gene | intact | torn |
|---|---|---|
| CENPM | 3434 | -7221 |
| CENPC | 5886 | -3995 |
| MIS18BP1 | 5086 | -1913 |
| CENPH | 2630 | -2732 |
| RUVBL1 | 2593 | -2291 |
| CENPN | 7025 | -552 |
| RSF1 | 2887 | -1132 |
| H2AC18 | 2185 | -29 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| CENPC | 5886 | -3995 |
| CENPH | 2630 | -2732 |
| CENPI | 4264 | 2186 |
| CENPK | 6942 | 2669 |
| CENPL | -73 | 4510 |
| CENPM | 3434 | -7221 |
| CENPN | 7025 | -552 |
| CENPO | 5044 | 1367 |
| CENPP | 3967 | 1210 |
| CENPQ | -900 | -5156 |
| CENPT | 5987 | 6782 |
| CENPU | 7143 | 3041 |
| CENPW | 5443 | 4580 |
| H2AC18 | 2185 | -29 |
| H2AC6 | -8239 | -7392 |
| H2AJ | 5204 | 5176 |
| H2AZ2 | -2563 | -3313 |
| H2BC12 | -1828 | -2886 |
| H2BC21 | -8428 | -7833 |
| HJURP | 7460 | 3752 |
| ITGB3BP | 6446 | 4864 |
| KNL1 | 3670 | 923 |
| MIS18A | 3155 | 2665 |
| MIS18BP1 | 5086 | -1913 |
| NPM1 | 3762 | 5803 |
| RBBP4 | -4923 | -2598 |
| RBBP7 | -5511 | -5492 |
| RSF1 | 2887 | -1132 |
| RUVBL1 | 2593 | -2291 |
| SMARCA5 | -47 | -4639 |
Nitric oxide stimulates guanylate cyclase
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.000131 |
| p.adjustMANOVA | 0.000999 |
| s.dist | 0.568 |
| s.intact | -0.186 |
| s.torn | -0.537 |
| p.intact | 0.184 |
| p.torn | 0.000126 |
| Gene | intact | torn |
|---|---|---|
| PRKG1 | -8079 | -7881 |
| NOS1 | -8498 | -6524 |
| NOS3 | -4634 | -8199 |
| PDE5A | -4008 | -8375 |
| PDE2A | -4372 | -7510 |
| PDE9A | -3662 | -7829 |
| GUCY1A2 | -6053 | -4143 |
| KCNMB4 | -3545 | -6565 |
| PDE11A | -8037 | -2696 |
| IRAG1 | -2388 | -8239 |
| KCNMB3 | -3021 | -5531 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| GUCY1A2 | -6053 | -4143 |
| IRAG1 | -2388 | -8239 |
| ITPR1 | 3943 | -348 |
| KCNMA1 | 3864 | 1838 |
| KCNMB1 | 4005 | -2159 |
| KCNMB3 | -3021 | -5531 |
| KCNMB4 | -3545 | -6565 |
| NOS1 | -8498 | -6524 |
| NOS3 | -4634 | -8199 |
| PDE10A | 2889 | -5644 |
| PDE11A | -8037 | -2696 |
| PDE1A | 2724 | -1231 |
| PDE1B | 3877 | 2195 |
| PDE2A | -4372 | -7510 |
| PDE5A | -4008 | -8375 |
| PDE9A | -3662 | -7829 |
| PRKG1 | -8079 | -7881 |
Degradation of cysteine and homocysteine
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00145 |
| p.adjustMANOVA | 0.00681 |
| s.dist | 0.511 |
| s.intact | -0.491 |
| s.torn | -0.143 |
| p.intact | 0.00147 |
| p.torn | 0.353 |
| Gene | intact | torn |
|---|---|---|
| GADL1 | -8427 | -6974 |
| GOT2 | -8232 | -6188 |
| TXN2 | -7256 | -5418 |
| TST | -7517 | -4182 |
| SUOX | -8048 | -3636 |
| FMO1 | -6999 | -3346 |
| TSTD1 | -6275 | -2811 |
| SLC25A10 | -5385 | -1069 |
| ADO | -306 | -788 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ADO | -306 | -788 |
| CDO1 | 2620 | 4283 |
| CSAD | -403 | 5551 |
| CTH | -4264 | 607 |
| ETHE1 | 3933 | 1874 |
| FMO1 | -6999 | -3346 |
| GADL1 | -8427 | -6974 |
| GOT2 | -8232 | -6188 |
| MPST | -6733 | 1705 |
| SLC25A10 | -5385 | -1069 |
| SUOX | -8048 | -3636 |
| TST | -7517 | -4182 |
| TSTD1 | -6275 | -2811 |
| TXN2 | -7256 | -5418 |
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 4.31e-05 |
| p.adjustMANOVA | 0.00042 |
| s.dist | 0.456 |
| s.intact | 0.446 |
| s.torn | 0.0986 |
| p.intact | 0.000157 |
| p.torn | 0.403 |
| Gene | intact | torn |
|---|---|---|
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| RAD50 | 3782 | 936 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 4.31e-05 |
| p.adjustMANOVA | 0.00042 |
| s.dist | 0.456 |
| s.intact | 0.446 |
| s.torn | 0.0986 |
| p.intact | 0.000157 |
| p.torn | 0.403 |
| Gene | intact | torn |
|---|---|---|
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| RAD50 | 3782 | 936 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 4.31e-05 |
| p.adjustMANOVA | 0.00042 |
| s.dist | 0.456 |
| s.intact | 0.446 |
| s.torn | 0.0986 |
| p.intact | 0.000157 |
| p.torn | 0.403 |
| Gene | intact | torn |
|---|---|---|
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| RAD50 | 3782 | 936 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Defective homologous recombination repair (HRR) due to PALB2 loss of function
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 4.31e-05 |
| p.adjustMANOVA | 0.00042 |
| s.dist | 0.456 |
| s.intact | 0.446 |
| s.torn | 0.0986 |
| p.intact | 0.000157 |
| p.torn | 0.403 |
| Gene | intact | torn |
|---|---|---|
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| RAD50 | 3782 | 936 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Impaired BRCA2 binding to PALB2
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 6.95e-05 |
| p.adjustMANOVA | 0.000583 |
| s.dist | 0.464 |
| s.intact | 0.451 |
| s.torn | 0.11 |
| p.intact | 0.000183 |
| p.torn | 0.36 |
| Gene | intact | torn |
|---|---|---|
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| RAD50 | 3782 | 936 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Platelet calcium homeostasis
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.00139 |
| p.adjustMANOVA | 0.00664 |
| s.dist | 0.275 |
| s.intact | 0.0695 |
| s.torn | -0.266 |
| p.intact | 0.564 |
| p.torn | 0.0271 |
| Gene | intact | torn |
|---|---|---|
| P2RX1 | 2892 | -7994 |
| CALM1 | 4372 | -3021 |
| ATP2A3 | 1104 | -8216 |
| TRPC6 | 1075 | -8282 |
| ITPR2 | 4551 | -765 |
| ITPR1 | 3943 | -348 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATP2A1 | -4530 | -3494 |
| ATP2A2 | -8536 | -6270 |
| ATP2A3 | 1104 | -8216 |
| ATP2B1 | 5748 | 102 |
| ATP2B2 | -7837 | -6914 |
| ATP2B4 | 7181 | 4148 |
| CALM1 | 4372 | -3021 |
| ITPR1 | 3943 | -348 |
| ITPR2 | 4551 | -765 |
| ITPR3 | 5707 | 5027 |
| ORAI1 | -5403 | -8010 |
| ORAI2 | 7074 | 5817 |
| P2RX1 | 2892 | -7994 |
| P2RX4 | 6749 | 6836 |
| P2RX5 | -8327 | -7985 |
| P2RX6 | -7996 | -5682 |
| P2RX7 | 5458 | 7269 |
| SLC8A1 | 3408 | 3141 |
| SLC8A3 | -8345 | -7540 |
| SRI | 6171 | 194 |
| STIM1 | -7845 | -6885 |
| TRPC3 | -6435 | -7460 |
| TRPC6 | 1075 | -8282 |
Leading Strand Synthesis
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00222 |
| p.adjustMANOVA | 0.00961 |
| s.dist | 0.497 |
| s.intact | 0.476 |
| s.torn | 0.142 |
| p.intact | 0.00204 |
| p.torn | 0.358 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| POLD1 | 5959 | 6843 |
| PCNA | 7128 | 3916 |
| POLA2 | 4859 | 5388 |
| POLD4 | 5674 | 4197 |
| RFC2 | 5723 | 2278 |
| POLD3 | 7055 | 1627 |
| PRIM2 | 3458 | 332 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| PCNA | 7128 | 3916 |
| POLA1 | -4853 | -3047 |
| POLA2 | 4859 | 5388 |
| POLD1 | 5959 | 6843 |
| POLD2 | -3310 | -1710 |
| POLD3 | 7055 | 1627 |
| POLD4 | 5674 | 4197 |
| PRIM1 | 2825 | -2043 |
| PRIM2 | 3458 | 332 |
| RFC1 | 3696 | -2219 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
Polymerase switching
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00222 |
| p.adjustMANOVA | 0.00961 |
| s.dist | 0.497 |
| s.intact | 0.476 |
| s.torn | 0.142 |
| p.intact | 0.00204 |
| p.torn | 0.358 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| POLD1 | 5959 | 6843 |
| PCNA | 7128 | 3916 |
| POLA2 | 4859 | 5388 |
| POLD4 | 5674 | 4197 |
| RFC2 | 5723 | 2278 |
| POLD3 | 7055 | 1627 |
| PRIM2 | 3458 | 332 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| PCNA | 7128 | 3916 |
| POLA1 | -4853 | -3047 |
| POLA2 | 4859 | 5388 |
| POLD1 | 5959 | 6843 |
| POLD2 | -3310 | -1710 |
| POLD3 | 7055 | 1627 |
| POLD4 | 5674 | 4197 |
| PRIM1 | 2825 | -2043 |
| PRIM2 | 3458 | 332 |
| RFC1 | 3696 | -2219 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
Regulation of pyruvate dehydrogenase (PDH) complex
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00047 |
| p.adjustMANOVA | 0.00284 |
| s.dist | 0.577 |
| s.intact | -0.539 |
| s.torn | -0.207 |
| p.intact | 3e-04 |
| p.torn | 0.166 |
| Gene | intact | torn |
|---|---|---|
| PDHX | -8084 | -6771 |
| PDK2 | -8334 | -6172 |
| DLAT | -7750 | -6218 |
| PDHB | -7226 | -6667 |
| DLD | -7856 | -5437 |
| PDHA1 | -7678 | -4488 |
| GSTZ1 | -5665 | -5879 |
| PDP2 | -4556 | -4957 |
| PDP1 | -6550 | -1562 |
| PDK4 | -8361 | -1219 |
| RXRA | -5323 | -542 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| DLAT | -7750 | -6218 |
| DLD | -7856 | -5437 |
| GSTZ1 | -5665 | -5879 |
| PDHA1 | -7678 | -4488 |
| PDHB | -7226 | -6667 |
| PDHX | -8084 | -6771 |
| PDK1 | 3534 | 7572 |
| PDK2 | -8334 | -6172 |
| PDK3 | 6056 | 3735 |
| PDK4 | -8361 | -1219 |
| PDP1 | -6550 | -1562 |
| PDP2 | -4556 | -4957 |
| PDPR | -2757 | 1925 |
| PPARD | -3103 | 7138 |
| RXRA | -5323 | -542 |
EPHA-mediated growth cone collapse
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.00261 |
| p.adjustMANOVA | 0.0111 |
| s.dist | 0.252 |
| s.intact | 0.237 |
| s.torn | -0.0862 |
| p.intact | 0.0494 |
| p.torn | 0.474 |
| Gene | intact | torn |
|---|---|---|
| MYL9 | 2237 | -6028 |
| MYL12B | 5657 | -1588 |
| MYH9 | 1969 | -2432 |
| ROCK1 | 6656 | -564 |
| YES1 | 1603 | -299 |
| EFNA5 | 4402 | -26 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| EFNA1 | -2721 | -8244 |
| EFNA4 | 4785 | 4083 |
| EFNA5 | 4402 | -26 |
| EPHA1 | 1656 | 4846 |
| EPHA2 | -4469 | -6308 |
| EPHA3 | 5258 | 2836 |
| EPHA4 | -5031 | -8357 |
| EPHA7 | -2950 | -8283 |
| FYN | 2870 | 1392 |
| LYN | 4448 | 5169 |
| MYH10 | -4274 | 34 |
| MYH11 | -1694 | -8369 |
| MYH14 | -8604 | -6578 |
| MYH9 | 1969 | -2432 |
| MYL12B | 5657 | -1588 |
| MYL6 | 6776 | 3637 |
| MYL9 | 2237 | -6028 |
| NGEF | 5446 | 6741 |
| RHOA | 6486 | 2625 |
| ROCK1 | 6656 | -564 |
| ROCK2 | -6105 | -4040 |
| SRC | 6846 | 6867 |
| YES1 | 1603 | -299 |
Cell-extracellular matrix interactions
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.011 |
| p.adjustMANOVA | 0.0385 |
| s.dist | 0.252 |
| s.intact | 0.241 |
| s.torn | -0.0756 |
| p.intact | 0.077 |
| p.torn | 0.579 |
| Gene | intact | torn |
|---|---|---|
| FBLIM1 | 2445 | -6202 |
| FLNA | 6269 | -2045 |
| RSU1 | 6587 | -932 |
| LIMS1 | 2765 | -1636 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ACTB | 6571 | 5482 |
| ACTG1 | 6780 | 6722 |
| ACTN1 | 4969 | 2456 |
| ARHGEF6 | -7752 | -3163 |
| FBLIM1 | 2445 | -6202 |
| FERMT2 | 4203 | 629 |
| FLNA | 6269 | -2045 |
| FLNC | -8559 | -7321 |
| ILK | 6992 | 4172 |
| ITGB1 | 6693 | 3328 |
| LIMS1 | 2765 | -1636 |
| LIMS2 | -2214 | -8117 |
| PARVA | 5209 | 6200 |
| PARVB | -6056 | -6479 |
| PXN | -8417 | -7465 |
| RSU1 | 6587 | -932 |
| TESK1 | -6710 | -4301 |
| VASP | 5278 | 2309 |
RHO GTPases activate PAKs
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 0.00632 |
| p.adjustMANOVA | 0.0244 |
| s.dist | 0.24 |
| s.intact | 0.0912 |
| s.torn | -0.222 |
| p.intact | 0.47 |
| p.torn | 0.0785 |
| Gene | intact | torn |
|---|---|---|
| MYL9 | 2237 | -6028 |
| CALM1 | 4372 | -3021 |
| FLNA | 6269 | -2045 |
| MYL12B | 5657 | -1588 |
| CDC42 | 4018 | -1248 |
| MYH9 | 1969 | -2432 |
| PPP1R12A | 225 | -5500 |
| PAK2 | 279 | -1263 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| CALM1 | 4372 | -3021 |
| CDC42 | 4018 | -1248 |
| CTTN | 2362 | 6360 |
| FLNA | 6269 | -2045 |
| LIMK1 | 3007 | 6634 |
| MYH10 | -4274 | 34 |
| MYH11 | -1694 | -8369 |
| MYH14 | -8604 | -6578 |
| MYH9 | 1969 | -2432 |
| MYL12B | 5657 | -1588 |
| MYL6 | 6776 | 3637 |
| MYL9 | 2237 | -6028 |
| MYLK | -1412 | -7563 |
| NF2 | -4173 | 1785 |
| PAK1 | -1759 | 833 |
| PAK2 | 279 | -1263 |
| PAK3 | -3836 | -3362 |
| PPP1CB | -6609 | -6787 |
| PPP1R12A | 225 | -5500 |
| PPP1R12B | -7467 | -7943 |
| RAC1 | 6497 | 542 |
Peroxisomal lipid metabolism
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 9.39e-05 |
| p.adjustMANOVA | 0.000744 |
| s.dist | 0.438 |
| s.intact | -0.423 |
| s.torn | -0.114 |
| p.intact | 0.000186 |
| p.torn | 0.315 |
| Gene | intact | torn |
|---|---|---|
| PHYH | -8111 | -6602 |
| ECI2 | -7768 | -5040 |
| DECR2 | -6361 | -4811 |
| ACOXL | -5724 | -5102 |
| MLYCD | -8024 | -3471 |
| NUDT19 | -8114 | -2935 |
| HACL1 | -3844 | -6155 |
| ACOX1 | -7138 | -3096 |
| CRAT | -6925 | -2751 |
| SCP2 | -4725 | -3863 |
| EHHADH | -4705 | -3446 |
| ALDH3A2 | -5541 | -2188 |
| NUDT7 | -3527 | -2163 |
| ACBD5 | -4110 | -1740 |
| HSD17B4 | -3802 | -1119 |
| PECR | -7499 | -246 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ABCD1 | -3927 | 2833 |
| ACAA1 | -4993 | 809 |
| ACBD4 | -1831 | 3248 |
| ACBD5 | -4110 | -1740 |
| ACOT4 | 6411 | 6875 |
| ACOT8 | -6885 | 2486 |
| ACOX1 | -7138 | -3096 |
| ACOX2 | -6185 | 4108 |
| ACOX3 | 1693 | 4710 |
| ACOXL | -5724 | -5102 |
| ALDH3A2 | -5541 | -2188 |
| AMACR | 1518 | -129 |
| CRAT | -6925 | -2751 |
| CROT | 1985 | -736 |
| DECR2 | -6361 | -4811 |
| ECI2 | -7768 | -5040 |
| EHHADH | -4705 | -3446 |
| HACL1 | -3844 | -6155 |
| HSD17B4 | -3802 | -1119 |
| MLYCD | -8024 | -3471 |
| NUDT19 | -8114 | -2935 |
| NUDT7 | -3527 | -2163 |
| PECR | -7499 | -246 |
| PHYH | -8111 | -6602 |
| SCP2 | -4725 | -3863 |
| SLC25A17 | 4842 | -1139 |
Resolution of Sister Chromatid Cohesion
| metric | value |
|---|---|
| setSize | 109 |
| pMANOVA | 1.56e-14 |
| p.adjustMANOVA | 1.42e-12 |
| s.dist | 0.347 |
| s.intact | 0.345 |
| s.torn | 0.0355 |
| p.intact | 4.91e-10 |
| p.torn | 0.522 |
| Gene | intact | torn |
|---|---|---|
| CENPT | 5987 | 6782 |
| TUBB2A | 6868 | 5864 |
| TUBB3 | 6963 | 5440 |
| SEC13 | 5933 | 6119 |
| ZWINT | 7508 | 4600 |
| DYNLL1 | 7367 | 4660 |
| PLK1 | 6019 | 5428 |
| ITGB3BP | 6446 | 4864 |
| CENPF | 7470 | 3944 |
| TUBA1B | 7247 | 3991 |
| AURKB | 7215 | 3842 |
| DSN1 | 7251 | 3631 |
| B9D2 | 5925 | 4121 |
| RCC2 | 6514 | 3607 |
| BUB1B | 6902 | 3288 |
| CENPU | 7143 | 3041 |
| NDEL1 | 5223 | 3922 |
| CDC20 | 6953 | 2869 |
| TUBA1A | 5947 | 3199 |
| CENPK | 6942 | 2669 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| AHCTF1 | -1868 | -2476 |
| AURKB | 7215 | 3842 |
| B9D2 | 5925 | 4121 |
| BIRC5 | 7504 | -35 |
| BUB1 | 6917 | 1846 |
| BUB1B | 6902 | 3288 |
| BUB3 | 4821 | 3230 |
| CCNB1 | 7195 | 7 |
| CCNB2 | 6981 | 2021 |
| CDC20 | 6953 | 2869 |
| CDCA5 | 7366 | -93 |
| CDK1 | 7480 | -1802 |
| CENPC | 5886 | -3995 |
| CENPE | 7455 | 2472 |
| CENPF | 7470 | 3944 |
| CENPH | 2630 | -2732 |
| CENPI | 4264 | 2186 |
| CENPK | 6942 | 2669 |
| CENPL | -73 | 4510 |
| CENPM | 3434 | -7221 |
| CENPN | 7025 | -552 |
| CENPO | 5044 | 1367 |
| CENPP | 3967 | 1210 |
| CENPQ | -900 | -5156 |
| CENPT | 5987 | 6782 |
| CENPU | 7143 | 3041 |
| CKAP5 | -2281 | -3640 |
| CLASP1 | -8168 | -5847 |
| CLASP2 | -7243 | -6164 |
| CLIP1 | -7034 | -7091 |
| DSN1 | 7251 | 3631 |
| DYNC1H1 | -2588 | -2225 |
| DYNC1I1 | -7524 | -8372 |
| DYNC1I2 | 7346 | 1786 |
| DYNC1LI1 | -4750 | -6066 |
| DYNC1LI2 | 2085 | 7232 |
| DYNLL1 | 7367 | 4660 |
| DYNLL2 | -7843 | -5968 |
| HDAC8 | 2117 | -714 |
| INCENP | 462 | 6309 |
| ITGB3BP | 6446 | 4864 |
| KIF2A | 5803 | 560 |
| KIF2C | 7456 | 1988 |
| KNL1 | 3670 | 923 |
| KNTC1 | 7234 | 1447 |
| MAD1L1 | 4218 | 4048 |
| MAD2L1 | 5383 | 80 |
| MAPRE1 | 6255 | 2175 |
| MIS12 | -4782 | -2902 |
| NDC80 | 7467 | -2392 |
| NDE1 | 3097 | 623 |
| NDEL1 | 5223 | 3922 |
| NSL1 | -478 | -1439 |
| NUDC | -2830 | -3360 |
| NUF2 | 7336 | 1899 |
| NUP107 | 5578 | 107 |
| NUP133 | -6373 | -3983 |
| NUP160 | 399 | -2337 |
| NUP37 | 1446 | -1552 |
| NUP43 | -5006 | -5784 |
| NUP85 | 5698 | 1531 |
| NUP98 | -6242 | -5221 |
| PAFAH1B1 | -5396 | -2624 |
| PDS5A | 5991 | 480 |
| PDS5B | 4428 | 454 |
| PLK1 | 6019 | 5428 |
| PMF1 | -6638 | -3176 |
| PPP1CC | -723 | -2464 |
| PPP2CA | -5147 | -4250 |
| PPP2CB | -3417 | -5559 |
| PPP2R1A | -6465 | -4354 |
| PPP2R1B | -196 | 179 |
| PPP2R5A | -7766 | -5250 |
| PPP2R5B | 1129 | 5974 |
| PPP2R5C | 954 | -3354 |
| PPP2R5D | -6774 | -3261 |
| PPP2R5E | -414 | -5215 |
| RAD21 | -3208 | -5426 |
| RANBP2 | -2738 | -1042 |
| RANGAP1 | 3694 | -1800 |
| RCC2 | 6514 | 3607 |
| RPS27 | 1993 | 6981 |
| SEC13 | 5933 | 6119 |
| SEH1L | 2378 | 35 |
| SGO2 | 6905 | 1342 |
| SKA1 | 2798 | -2595 |
| SKA2 | 3713 | -1752 |
| SMC1A | 4379 | 1066 |
| SMC3 | 6264 | -116 |
| SPC24 | 6206 | -1243 |
| SPDL1 | 5457 | -2599 |
| STAG1 | 669 | 1563 |
| STAG2 | 2546 | 1341 |
| TAOK1 | 3854 | 2554 |
| TUBA1A | 5947 | 3199 |
| TUBA1B | 7247 | 3991 |
| TUBA1C | 6988 | 2404 |
| TUBA4A | -8494 | -7581 |
| TUBA8 | -8458 | -6784 |
| TUBB2A | 6868 | 5864 |
| TUBB2B | -2347 | 7708 |
| TUBB3 | 6963 | 5440 |
| TUBB4B | 5934 | -1928 |
| TUBB6 | 7063 | 2423 |
| WAPL | -3750 | -1124 |
| XPO1 | -2792 | -156 |
| ZW10 | -1065 | -465 |
| ZWILCH | 5450 | 1870 |
| ZWINT | 7508 | 4600 |
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 8.06e-05 |
| p.adjustMANOVA | 0.000661 |
| s.dist | 0.448 |
| s.intact | 0.431 |
| s.torn | 0.123 |
| p.intact | 0.000142 |
| p.torn | 0.276 |
| Gene | intact | torn |
|---|---|---|
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| XRCC3 | 1650 | 3107 |
| RTEL1 | 1390 | 3079 |
| RAD50 | 3782 | 936 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RTEL1 | 1390 | 3079 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
| XRCC3 | 1650 | 3107 |
Defective homologous recombination repair (HRR) due to BRCA2 loss of function
| metric | value |
|---|---|
| setSize | 39 |
| pMANOVA | 9.03e-06 |
| p.adjustMANOVA | 0.000114 |
| s.dist | 0.359 |
| s.intact | 0.356 |
| s.torn | 0.0485 |
| p.intact | 0.00012 |
| p.torn | 0.6 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| RAD9A | 3037 | 4622 |
| BRCA1 | 3736 | 3627 |
| RFC2 | 5723 | 2278 |
| ATRIP | 2978 | 2726 |
| RBBP8 | 6366 | 897 |
| TOPBP1 | 5609 | 932 |
| RAD50 | 3782 | 936 |
| ATR | 4357 | 557 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| HUS1 | -3408 | -227 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RAD9A | 3037 | 4622 |
| RBBP8 | 6366 | 897 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RHNO1 | 4417 | -1499 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| TOPBP1 | 5609 | 932 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Diseases of DNA Double-Strand Break Repair
| metric | value |
|---|---|
| setSize | 39 |
| pMANOVA | 9.03e-06 |
| p.adjustMANOVA | 0.000114 |
| s.dist | 0.359 |
| s.intact | 0.356 |
| s.torn | 0.0485 |
| p.intact | 0.00012 |
| p.torn | 0.6 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| RAD9A | 3037 | 4622 |
| BRCA1 | 3736 | 3627 |
| RFC2 | 5723 | 2278 |
| ATRIP | 2978 | 2726 |
| RBBP8 | 6366 | 897 |
| TOPBP1 | 5609 | 932 |
| RAD50 | 3782 | 936 |
| ATR | 4357 | 557 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| HUS1 | -3408 | -227 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RAD9A | 3037 | 4622 |
| RBBP8 | 6366 | 897 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RHNO1 | 4417 | -1499 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| TOPBP1 | 5609 | 932 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
mitochondrial fatty acid beta-oxidation of saturated fatty acids
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 5.72e-05 |
| p.adjustMANOVA | 0.000518 |
| s.dist | 0.945 |
| s.intact | -0.804 |
| s.torn | -0.497 |
| p.intact | 1.08e-05 |
| p.torn | 0.00654 |
| Gene | intact | torn |
|---|---|---|
| ACADL | -8128 | -5962 |
| HADH | -8425 | -5609 |
| ACADM | -8237 | -5454 |
| HADHB | -7983 | -4705 |
| MECR | -7061 | -4984 |
| ACADS | -8083 | -3826 |
| ECHS1 | -7315 | -4209 |
| HADHA | -6658 | -3135 |
| ACADVL | -7115 | -1549 |
| ACSM3 | -1495 | -3700 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ACADL | -8128 | -5962 |
| ACADM | -8237 | -5454 |
| ACADS | -8083 | -3826 |
| ACADVL | -7115 | -1549 |
| ACSM3 | -1495 | -3700 |
| ECHS1 | -7315 | -4209 |
| HADH | -8425 | -5609 |
| HADHA | -6658 | -3135 |
| HADHB | -7983 | -4705 |
| MECR | -7061 | -4984 |
Laminin interactions
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 0.000486 |
| p.adjustMANOVA | 0.00291 |
| s.dist | 0.302 |
| s.intact | 0.0048 |
| s.torn | -0.302 |
| p.intact | 0.964 |
| p.torn | 0.00493 |
| Gene | intact | torn |
|---|---|---|
| COL4A1 | 3657 | -5377 |
| COL4A2 | 5341 | -3112 |
| ITGA3 | 1979 | -8085 |
| COL18A1 | 1692 | -7552 |
| ITGA2 | 1112 | -5244 |
| HSPG2 | 659 | -4336 |
| LAMB1 | 2159 | -825 |
| LAMC1 | 1788 | -463 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| COL18A1 | 1692 | -7552 |
| COL4A1 | 3657 | -5377 |
| COL4A2 | 5341 | -3112 |
| COL4A3 | -8575 | -1881 |
| COL4A4 | -8369 | -6093 |
| COL4A5 | -6750 | -7911 |
| COL4A6 | -6071 | -5252 |
| COL7A1 | 5618 | 7676 |
| HSPG2 | 659 | -4336 |
| ITGA1 | -2126 | -7849 |
| ITGA2 | 1112 | -5244 |
| ITGA3 | 1979 | -8085 |
| ITGA6 | -4406 | -7784 |
| ITGA7 | -7941 | -8014 |
| ITGAV | 7206 | 4725 |
| ITGB1 | 6693 | 3328 |
| ITGB4 | -1589 | -8159 |
| LAMA1 | 732 | 5278 |
| LAMA2 | -7980 | -7323 |
| LAMA3 | -5110 | -7367 |
| LAMA4 | 5177 | 3663 |
| LAMA5 | -3168 | -8328 |
| LAMB1 | 2159 | -825 |
| LAMB2 | 4093 | 5019 |
| LAMB3 | 1067 | 7359 |
| LAMC1 | 1788 | -463 |
| LAMC2 | -944 | -6993 |
| NID1 | -4541 | -5444 |
| NID2 | 3669 | 7041 |
Homologous DNA Pairing and Strand Exchange
| metric | value |
|---|---|
| setSize | 41 |
| pMANOVA | 3.98e-06 |
| p.adjustMANOVA | 5.58e-05 |
| s.dist | 0.373 |
| s.intact | 0.367 |
| s.torn | 0.0626 |
| p.intact | 4.71e-05 |
| p.torn | 0.488 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| RAD9A | 3037 | 4622 |
| BRCA1 | 3736 | 3627 |
| RFC2 | 5723 | 2278 |
| CHEK1 | 6736 | 1734 |
| ATRIP | 2978 | 2726 |
| RBBP8 | 6366 | 897 |
| TOPBP1 | 5609 | 932 |
| XRCC3 | 1650 | 3107 |
| RAD50 | 3782 | 936 |
| ATR | 4357 | 557 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| CHEK1 | 6736 | 1734 |
| DNA2 | 658 | 1898 |
| HUS1 | -3408 | -227 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RAD9A | 3037 | 4622 |
| RBBP8 | 6366 | 897 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RHNO1 | 4417 | -1499 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| TOPBP1 | 5609 | 932 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
| XRCC3 | 1650 | 3107 |
Mitochondrial Fatty Acid Beta-Oxidation
| metric | value |
|---|---|
| setSize | 34 |
| pMANOVA | 1.28e-06 |
| p.adjustMANOVA | 1.99e-05 |
| s.dist | 0.502 |
| s.intact | -0.472 |
| s.torn | -0.172 |
| p.intact | 1.9e-06 |
| p.torn | 0.0834 |
| Gene | intact | torn |
|---|---|---|
| ACADL | -8128 | -5962 |
| NDUFAB1 | -7245 | -6596 |
| HADH | -8425 | -5609 |
| ACADM | -8237 | -5454 |
| HADHB | -7983 | -4705 |
| ECI1 | -7483 | -4968 |
| ACOT1 | -6146 | -5943 |
| MECR | -7061 | -4984 |
| ACADS | -8083 | -3826 |
| ECHS1 | -7315 | -4209 |
| PCCB | -7355 | -4075 |
| DECR1 | -6348 | -4316 |
| ACOT2 | -8103 | -3066 |
| MCAT | -4950 | -4234 |
| HADHA | -6658 | -3135 |
| PCCA | -5911 | -3423 |
| ACADVL | -7115 | -1549 |
| ACAA2 | -6915 | -1403 |
| MMUT | -5311 | -1648 |
| ACSM3 | -1495 | -3700 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ACAA2 | -6915 | -1403 |
| ACAD10 | -5365 | 4388 |
| ACAD11 | 4416 | 7587 |
| ACADL | -8128 | -5962 |
| ACADM | -8237 | -5454 |
| ACADS | -8083 | -3826 |
| ACADVL | -7115 | -1549 |
| ACBD6 | 397 | 4733 |
| ACBD7 | -9 | -5841 |
| ACOT1 | -6146 | -5943 |
| ACOT11 | -4509 | -771 |
| ACOT13 | -3167 | 756 |
| ACOT2 | -8103 | -3066 |
| ACOT7 | 7054 | 3203 |
| ACOT9 | 5320 | 2704 |
| ACSF2 | -6274 | 2579 |
| ACSM3 | -1495 | -3700 |
| DBI | 581 | -730 |
| DECR1 | -6348 | -4316 |
| ECHS1 | -7315 | -4209 |
| ECI1 | -7483 | -4968 |
| HADH | -8425 | -5609 |
| HADHA | -6658 | -3135 |
| HADHB | -7983 | -4705 |
| MCAT | -4950 | -4234 |
| MCEE | -3649 | 3460 |
| MECR | -7061 | -4984 |
| MMAA | -2946 | -1714 |
| MMUT | -5311 | -1648 |
| NDUFAB1 | -7245 | -6596 |
| PCCA | -5911 | -3423 |
| PCCB | -7355 | -4075 |
| PCTP | 3251 | 4535 |
| THEM4 | -7194 | 663 |
Activation of ATR in response to replication stress
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 0.000906 |
| p.adjustMANOVA | 0.00477 |
| s.dist | 0.261 |
| s.intact | 0.258 |
| s.torn | -0.034 |
| p.intact | 0.0128 |
| p.torn | 0.743 |
| Gene | intact | torn |
|---|---|---|
| CLSPN | 5245 | -4177 |
| RFC5 | 2578 | -4853 |
| DBF4 | 3959 | -2546 |
| ORC5 | 835 | -2773 |
| RPA3 | 6219 | -150 |
| MCM3 | 6440 | -30 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| CDC6 | 7315 | 2444 |
| CDC7 | 6225 | 524 |
| CDK2 | 3865 | 1915 |
| CHEK1 | 6736 | 1734 |
| CLSPN | 5245 | -4177 |
| DBF4 | 3959 | -2546 |
| HUS1 | -3408 | -227 |
| MCM2 | -3130 | 3551 |
| MCM3 | 6440 | -30 |
| MCM4 | 2147 | 1065 |
| MCM5 | 3678 | 4616 |
| MCM6 | 6633 | 4634 |
| MCM7 | 6826 | 5899 |
| MCM8 | -5030 | -6282 |
| ORC2 | -1009 | -3566 |
| ORC3 | -4680 | -3226 |
| ORC4 | -5431 | -5942 |
| ORC5 | 835 | -2773 |
| ORC6 | -439 | -7859 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD9A | 3037 | 4622 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
| metric | value |
|---|---|
| setSize | 86 |
| pMANOVA | 5.3e-10 |
| p.adjustMANOVA | 1.55e-08 |
| s.dist | 0.309 |
| s.intact | 0.308 |
| s.torn | 0.0171 |
| p.intact | 7.83e-07 |
| p.torn | 0.784 |
| Gene | intact | torn |
|---|---|---|
| CENPT | 5987 | 6782 |
| SEC13 | 5933 | 6119 |
| ZWINT | 7508 | 4600 |
| DYNLL1 | 7367 | 4660 |
| PLK1 | 6019 | 5428 |
| ITGB3BP | 6446 | 4864 |
| CENPF | 7470 | 3944 |
| AURKB | 7215 | 3842 |
| DSN1 | 7251 | 3631 |
| B9D2 | 5925 | 4121 |
| RCC2 | 6514 | 3607 |
| BUB1B | 6902 | 3288 |
| CENPU | 7143 | 3041 |
| NDEL1 | 5223 | 3922 |
| CDC20 | 6953 | 2869 |
| CENPK | 6942 | 2669 |
| CENPE | 7455 | 2472 |
| MAD1L1 | 4218 | 4048 |
| BUB3 | 4821 | 3230 |
| DYNC1LI2 | 2085 | 7232 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| AHCTF1 | -1868 | -2476 |
| AURKB | 7215 | 3842 |
| B9D2 | 5925 | 4121 |
| BIRC5 | 7504 | -35 |
| BUB1 | 6917 | 1846 |
| BUB1B | 6902 | 3288 |
| BUB3 | 4821 | 3230 |
| CDC20 | 6953 | 2869 |
| CENPC | 5886 | -3995 |
| CENPE | 7455 | 2472 |
| CENPF | 7470 | 3944 |
| CENPH | 2630 | -2732 |
| CENPI | 4264 | 2186 |
| CENPK | 6942 | 2669 |
| CENPL | -73 | 4510 |
| CENPM | 3434 | -7221 |
| CENPN | 7025 | -552 |
| CENPO | 5044 | 1367 |
| CENPP | 3967 | 1210 |
| CENPQ | -900 | -5156 |
| CENPT | 5987 | 6782 |
| CENPU | 7143 | 3041 |
| CKAP5 | -2281 | -3640 |
| CLASP1 | -8168 | -5847 |
| CLASP2 | -7243 | -6164 |
| CLIP1 | -7034 | -7091 |
| DSN1 | 7251 | 3631 |
| DYNC1H1 | -2588 | -2225 |
| DYNC1I1 | -7524 | -8372 |
| DYNC1I2 | 7346 | 1786 |
| DYNC1LI1 | -4750 | -6066 |
| DYNC1LI2 | 2085 | 7232 |
| DYNLL1 | 7367 | 4660 |
| DYNLL2 | -7843 | -5968 |
| INCENP | 462 | 6309 |
| ITGB3BP | 6446 | 4864 |
| KIF2A | 5803 | 560 |
| KIF2C | 7456 | 1988 |
| KNL1 | 3670 | 923 |
| KNTC1 | 7234 | 1447 |
| MAD1L1 | 4218 | 4048 |
| MAD2L1 | 5383 | 80 |
| MAPRE1 | 6255 | 2175 |
| MIS12 | -4782 | -2902 |
| NDC80 | 7467 | -2392 |
| NDE1 | 3097 | 623 |
| NDEL1 | 5223 | 3922 |
| NSL1 | -478 | -1439 |
| NUDC | -2830 | -3360 |
| NUF2 | 7336 | 1899 |
| NUP107 | 5578 | 107 |
| NUP133 | -6373 | -3983 |
| NUP160 | 399 | -2337 |
| NUP37 | 1446 | -1552 |
| NUP43 | -5006 | -5784 |
| NUP85 | 5698 | 1531 |
| NUP98 | -6242 | -5221 |
| PAFAH1B1 | -5396 | -2624 |
| PLK1 | 6019 | 5428 |
| PMF1 | -6638 | -3176 |
| PPP1CC | -723 | -2464 |
| PPP2CA | -5147 | -4250 |
| PPP2CB | -3417 | -5559 |
| PPP2R1A | -6465 | -4354 |
| PPP2R1B | -196 | 179 |
| PPP2R5A | -7766 | -5250 |
| PPP2R5B | 1129 | 5974 |
| PPP2R5C | 954 | -3354 |
| PPP2R5D | -6774 | -3261 |
| PPP2R5E | -414 | -5215 |
| RANBP2 | -2738 | -1042 |
| RANGAP1 | 3694 | -1800 |
| RCC2 | 6514 | 3607 |
| RPS27 | 1993 | 6981 |
| SEC13 | 5933 | 6119 |
| SEH1L | 2378 | 35 |
| SGO2 | 6905 | 1342 |
| SKA1 | 2798 | -2595 |
| SKA2 | 3713 | -1752 |
| SPC24 | 6206 | -1243 |
| SPDL1 | 5457 | -2599 |
| TAOK1 | 3854 | 2554 |
| XPO1 | -2792 | -156 |
| ZW10 | -1065 | -465 |
| ZWILCH | 5450 | 1870 |
| ZWINT | 7508 | 4600 |
Amplification of signal from the kinetochores
| metric | value |
|---|---|
| setSize | 86 |
| pMANOVA | 5.3e-10 |
| p.adjustMANOVA | 1.55e-08 |
| s.dist | 0.309 |
| s.intact | 0.308 |
| s.torn | 0.0171 |
| p.intact | 7.83e-07 |
| p.torn | 0.784 |
| Gene | intact | torn |
|---|---|---|
| CENPT | 5987 | 6782 |
| SEC13 | 5933 | 6119 |
| ZWINT | 7508 | 4600 |
| DYNLL1 | 7367 | 4660 |
| PLK1 | 6019 | 5428 |
| ITGB3BP | 6446 | 4864 |
| CENPF | 7470 | 3944 |
| AURKB | 7215 | 3842 |
| DSN1 | 7251 | 3631 |
| B9D2 | 5925 | 4121 |
| RCC2 | 6514 | 3607 |
| BUB1B | 6902 | 3288 |
| CENPU | 7143 | 3041 |
| NDEL1 | 5223 | 3922 |
| CDC20 | 6953 | 2869 |
| CENPK | 6942 | 2669 |
| CENPE | 7455 | 2472 |
| MAD1L1 | 4218 | 4048 |
| BUB3 | 4821 | 3230 |
| DYNC1LI2 | 2085 | 7232 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| AHCTF1 | -1868 | -2476 |
| AURKB | 7215 | 3842 |
| B9D2 | 5925 | 4121 |
| BIRC5 | 7504 | -35 |
| BUB1 | 6917 | 1846 |
| BUB1B | 6902 | 3288 |
| BUB3 | 4821 | 3230 |
| CDC20 | 6953 | 2869 |
| CENPC | 5886 | -3995 |
| CENPE | 7455 | 2472 |
| CENPF | 7470 | 3944 |
| CENPH | 2630 | -2732 |
| CENPI | 4264 | 2186 |
| CENPK | 6942 | 2669 |
| CENPL | -73 | 4510 |
| CENPM | 3434 | -7221 |
| CENPN | 7025 | -552 |
| CENPO | 5044 | 1367 |
| CENPP | 3967 | 1210 |
| CENPQ | -900 | -5156 |
| CENPT | 5987 | 6782 |
| CENPU | 7143 | 3041 |
| CKAP5 | -2281 | -3640 |
| CLASP1 | -8168 | -5847 |
| CLASP2 | -7243 | -6164 |
| CLIP1 | -7034 | -7091 |
| DSN1 | 7251 | 3631 |
| DYNC1H1 | -2588 | -2225 |
| DYNC1I1 | -7524 | -8372 |
| DYNC1I2 | 7346 | 1786 |
| DYNC1LI1 | -4750 | -6066 |
| DYNC1LI2 | 2085 | 7232 |
| DYNLL1 | 7367 | 4660 |
| DYNLL2 | -7843 | -5968 |
| INCENP | 462 | 6309 |
| ITGB3BP | 6446 | 4864 |
| KIF2A | 5803 | 560 |
| KIF2C | 7456 | 1988 |
| KNL1 | 3670 | 923 |
| KNTC1 | 7234 | 1447 |
| MAD1L1 | 4218 | 4048 |
| MAD2L1 | 5383 | 80 |
| MAPRE1 | 6255 | 2175 |
| MIS12 | -4782 | -2902 |
| NDC80 | 7467 | -2392 |
| NDE1 | 3097 | 623 |
| NDEL1 | 5223 | 3922 |
| NSL1 | -478 | -1439 |
| NUDC | -2830 | -3360 |
| NUF2 | 7336 | 1899 |
| NUP107 | 5578 | 107 |
| NUP133 | -6373 | -3983 |
| NUP160 | 399 | -2337 |
| NUP37 | 1446 | -1552 |
| NUP43 | -5006 | -5784 |
| NUP85 | 5698 | 1531 |
| NUP98 | -6242 | -5221 |
| PAFAH1B1 | -5396 | -2624 |
| PLK1 | 6019 | 5428 |
| PMF1 | -6638 | -3176 |
| PPP1CC | -723 | -2464 |
| PPP2CA | -5147 | -4250 |
| PPP2CB | -3417 | -5559 |
| PPP2R1A | -6465 | -4354 |
| PPP2R1B | -196 | 179 |
| PPP2R5A | -7766 | -5250 |
| PPP2R5B | 1129 | 5974 |
| PPP2R5C | 954 | -3354 |
| PPP2R5D | -6774 | -3261 |
| PPP2R5E | -414 | -5215 |
| RANBP2 | -2738 | -1042 |
| RANGAP1 | 3694 | -1800 |
| RCC2 | 6514 | 3607 |
| RPS27 | 1993 | 6981 |
| SEC13 | 5933 | 6119 |
| SEH1L | 2378 | 35 |
| SGO2 | 6905 | 1342 |
| SKA1 | 2798 | -2595 |
| SKA2 | 3713 | -1752 |
| SPC24 | 6206 | -1243 |
| SPDL1 | 5457 | -2599 |
| TAOK1 | 3854 | 2554 |
| XPO1 | -2792 | -156 |
| ZW10 | -1065 | -465 |
| ZWILCH | 5450 | 1870 |
| ZWINT | 7508 | 4600 |
Presynaptic phase of homologous DNA pairing and strand exchange
| metric | value |
|---|---|
| setSize | 38 |
| pMANOVA | 3.24e-05 |
| p.adjustMANOVA | 0.00033 |
| s.dist | 0.354 |
| s.intact | 0.349 |
| s.torn | 0.0606 |
| p.intact | 2e-04 |
| p.torn | 0.518 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| RAD9A | 3037 | 4622 |
| BRCA1 | 3736 | 3627 |
| RFC2 | 5723 | 2278 |
| CHEK1 | 6736 | 1734 |
| ATRIP | 2978 | 2726 |
| RBBP8 | 6366 | 897 |
| TOPBP1 | 5609 | 932 |
| RAD50 | 3782 | 936 |
| ATR | 4357 | 557 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| CHEK1 | 6736 | 1734 |
| DNA2 | 658 | 1898 |
| HUS1 | -3408 | -227 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RAD9A | 3037 | 4622 |
| RBBP8 | 6366 | 897 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RHNO1 | 4417 | -1499 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| TOPBP1 | 5609 | 932 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
Sema4D in semaphorin signaling
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 0.00917 |
| p.adjustMANOVA | 0.033 |
| s.dist | 0.203 |
| s.intact | 0.135 |
| s.torn | -0.151 |
| p.intact | 0.251 |
| p.torn | 0.2 |
| Gene | intact | torn |
|---|---|---|
| MYL9 | 2237 | -6028 |
| MYL12B | 5657 | -1588 |
| MET | 1339 | -5331 |
| PLXNB1 | 1391 | -4958 |
| ARHGEF12 | 1182 | -4806 |
| MYH9 | 1969 | -2432 |
| ROCK1 | 6656 | -564 |
| RND1 | 519 | -5036 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ARHGAP35 | -7733 | -1890 |
| ARHGEF11 | 2222 | 4984 |
| ARHGEF12 | 1182 | -4806 |
| ERBB2 | -4113 | 675 |
| LIMK1 | 3007 | 6634 |
| LIMK2 | -5558 | -6135 |
| MET | 1339 | -5331 |
| MYH10 | -4274 | 34 |
| MYH11 | -1694 | -8369 |
| MYH14 | -8604 | -6578 |
| MYH9 | 1969 | -2432 |
| MYL12B | 5657 | -1588 |
| MYL6 | 6776 | 3637 |
| MYL9 | 2237 | -6028 |
| PLXNB1 | 1391 | -4958 |
| RAC1 | 6497 | 542 |
| RHOA | 6486 | 2625 |
| RHOB | -928 | -1083 |
| RHOC | 7217 | 5303 |
| RND1 | 519 | -5036 |
| ROCK1 | 6656 | -564 |
| ROCK2 | -6105 | -4040 |
| RRAS | 7189 | 5453 |
| SEMA4D | -8400 | -7490 |
Peroxisomal protein import
| metric | value |
|---|---|
| setSize | 56 |
| pMANOVA | 2.44e-09 |
| p.adjustMANOVA | 5.77e-08 |
| s.dist | 0.469 |
| s.intact | -0.443 |
| s.torn | -0.156 |
| p.intact | 1.02e-08 |
| p.torn | 0.043 |
| Gene | intact | torn |
|---|---|---|
| PHYH | -8111 | -6602 |
| UBE2D1 | -8339 | -6040 |
| ECH1 | -8276 | -5322 |
| ZFAND6 | -6736 | -6417 |
| IDE | -6488 | -6483 |
| ECI2 | -7768 | -5040 |
| GNPAT | -6649 | -5605 |
| UBC | -5262 | -6300 |
| GSTK1 | -6753 | -4869 |
| UBB | -6221 | -4938 |
| DECR2 | -6361 | -4811 |
| PEX2 | -5133 | -5730 |
| MLYCD | -8024 | -3471 |
| EPHX2 | -7491 | -3538 |
| PEX12 | -5975 | -4353 |
| ACOT2 | -8103 | -3066 |
| NUDT19 | -8114 | -2935 |
| HACL1 | -3844 | -6155 |
| ACOX1 | -7138 | -3096 |
| PEX7 | -5027 | -4372 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ACAA1 | -4993 | 809 |
| ACOT2 | -8103 | -3066 |
| ACOT4 | 6411 | 6875 |
| ACOT8 | -6885 | 2486 |
| ACOX1 | -7138 | -3096 |
| ACOX2 | -6185 | 4108 |
| ACOX3 | 1693 | 4710 |
| AGPS | 5453 | 2506 |
| AMACR | 1518 | -129 |
| CAT | -7485 | -494 |
| CRAT | -6925 | -2751 |
| CROT | 1985 | -736 |
| DDO | -6698 | 553 |
| DECR2 | -6361 | -4811 |
| DHRS4 | -5219 | -1735 |
| ECH1 | -8276 | -5322 |
| ECI2 | -7768 | -5040 |
| EHHADH | -4705 | -3446 |
| EPHX2 | -7491 | -3538 |
| GNPAT | -6649 | -5605 |
| GSTK1 | -6753 | -4869 |
| HACL1 | -3844 | -6155 |
| HMGCL | -6829 | -507 |
| HSD17B4 | -3802 | -1119 |
| IDE | -6488 | -6483 |
| IDH1 | 463 | 2610 |
| LONP2 | -5655 | 652 |
| MLYCD | -8024 | -3471 |
| MPV17 | 5807 | 6478 |
| NUDT19 | -8114 | -2935 |
| NUDT7 | -3527 | -2163 |
| PAOX | 2918 | 3931 |
| PECR | -7499 | -246 |
| PEX1 | -3180 | -2465 |
| PEX10 | -3653 | -2399 |
| PEX12 | -5975 | -4353 |
| PEX13 | -4784 | -4019 |
| PEX14 | -4683 | 901 |
| PEX2 | -5133 | -5730 |
| PEX26 | -312 | -2621 |
| PEX5 | -6547 | -287 |
| PEX6 | -5775 | 2322 |
| PEX7 | -5027 | -4372 |
| PHYH | -8111 | -6602 |
| PIPOX | 3413 | 595 |
| RPS27A | 3318 | 3930 |
| SCP2 | -4725 | -3863 |
| TYSND1 | -5087 | 3634 |
| UBA52 | -361 | 5203 |
| UBB | -6221 | -4938 |
| UBC | -5262 | -6300 |
| UBE2D1 | -8339 | -6040 |
| UBE2D2 | -5245 | -3968 |
| UBE2D3 | -5224 | -3751 |
| USP9X | -1934 | -3767 |
| ZFAND6 | -6736 | -6417 |
Mitochondrial iron-sulfur cluster biogenesis
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00769 |
| p.adjustMANOVA | 0.0285 |
| s.dist | 0.495 |
| s.intact | -0.462 |
| s.torn | -0.178 |
| p.intact | 0.00392 |
| p.torn | 0.266 |
| Gene | intact | torn |
|---|---|---|
| GLRX5 | -7759 | -7343 |
| ISCA1 | -7411 | -7382 |
| ISCU | -6411 | -6609 |
| ISCA2 | -6964 | -5696 |
| FDX1 | -5935 | -5330 |
| FXN | -6702 | -3945 |
| NFS1 | -6060 | -3417 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| FDX1 | -5935 | -5330 |
| FDX2 | -1349 | 99 |
| FDXR | 120 | 1903 |
| FXN | -6702 | -3945 |
| GLRX5 | -7759 | -7343 |
| HSCB | -1221 | 6956 |
| ISCA1 | -7411 | -7382 |
| ISCA2 | -6964 | -5696 |
| ISCU | -6411 | -6609 |
| LYRM4 | 3808 | 2992 |
| NFS1 | -6060 | -3417 |
| SLC25A28 | -4196 | 2780 |
| SLC25A37 | -5661 | 2400 |
Impaired BRCA2 binding to RAD51
| metric | value |
|---|---|
| setSize | 33 |
| pMANOVA | 0.000234 |
| p.adjustMANOVA | 0.00161 |
| s.dist | 0.344 |
| s.intact | 0.339 |
| s.torn | 0.0622 |
| p.intact | 0.000763 |
| p.torn | 0.536 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| RAD9A | 3037 | 4622 |
| BRCA1 | 3736 | 3627 |
| RFC2 | 5723 | 2278 |
| ATRIP | 2978 | 2726 |
| RBBP8 | 6366 | 897 |
| TOPBP1 | 5609 | 932 |
| RAD50 | 3782 | 936 |
| ATR | 4357 | 557 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| HUS1 | -3408 | -227 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| NBN | 81 | -1834 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD9A | 3037 | 4622 |
| RBBP8 | 6366 | 897 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RHNO1 | 4417 | -1499 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| TOPBP1 | 5609 | 932 |
| WRN | 2229 | 116 |
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.000736 |
| p.adjustMANOVA | 0.00404 |
| s.dist | 0.44 |
| s.intact | -0.416 |
| s.torn | -0.146 |
| p.intact | 0.000562 |
| p.torn | 0.227 |
| Gene | intact | torn |
|---|---|---|
| FBXO32 | -8513 | -7546 |
| PPARGC1A | -8503 | -5926 |
| FOXO4 | -8202 | -5838 |
| SMAD3 | -7470 | -5179 |
| ABCA6 | -5155 | -6544 |
| SMAD4 | -7380 | -4397 |
| TRIM63 | -8582 | -3158 |
| SOD2 | -7200 | -3594 |
| FOXO6 | -3348 | -4035 |
| NR3C1 | -3857 | -2960 |
| CAT | -7485 | -494 |
| HDAC2 | -1216 | -2008 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ABCA6 | -5155 | -6544 |
| ATXN3 | 4244 | -466 |
| CAT | -7485 | -494 |
| FBXO32 | -8513 | -7546 |
| FOXO1 | 2382 | 383 |
| FOXO3 | -7289 | 593 |
| FOXO4 | -8202 | -5838 |
| FOXO6 | -3348 | -4035 |
| HDAC1 | 4793 | 2541 |
| HDAC2 | -1216 | -2008 |
| NR3C1 | -3857 | -2960 |
| PCK1 | 393 | 2057 |
| PLXNA4 | -8112 | 1825 |
| POMC | -4076 | 4923 |
| PPARGC1A | -8503 | -5926 |
| SIN3A | 1913 | -627 |
| SIRT3 | -6273 | 2085 |
| SMAD2 | 3750 | -1098 |
| SMAD3 | -7470 | -5179 |
| SMAD4 | -7380 | -4397 |
| SOD2 | -7200 | -3594 |
| SREBF1 | -4741 | 5556 |
| TRIM63 | -8582 | -3158 |
Diseases of DNA repair
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 3.15e-05 |
| p.adjustMANOVA | 0.000324 |
| s.dist | 0.297 |
| s.intact | 0.296 |
| s.torn | 0.0291 |
| p.intact | 0.000396 |
| p.torn | 0.728 |
| Gene | intact | torn |
|---|---|---|
| RFC4 | 6796 | 6946 |
| BRCA2 | 7330 | 5376 |
| MSH6 | 6912 | 5073 |
| ATM | 3410 | 6501 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| OGG1 | 4766 | 3377 |
| RAD9A | 3037 | 4622 |
| BRCA1 | 3736 | 3627 |
| RFC2 | 5723 | 2278 |
| ATRIP | 2978 | 2726 |
| RBBP8 | 6366 | 897 |
| TOPBP1 | 5609 | 932 |
| RAD50 | 3782 | 936 |
| ATR | 4357 | 557 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| ATR | 4357 | 557 |
| ATRIP | 2978 | 2726 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| HUS1 | -3408 | -227 |
| KAT5 | 180 | -266 |
| MLH1 | -5560 | -1408 |
| MRE11 | 4777 | 4133 |
| MSH2 | 1850 | -3107 |
| MSH3 | -1726 | 305 |
| MSH6 | 6912 | 5073 |
| MUTYH | -2197 | -225 |
| NBN | 81 | -1834 |
| NEIL1 | -476 | -554 |
| NTHL1 | 996 | -3622 |
| OGG1 | 4766 | 3377 |
| PALB2 | 3814 | -1455 |
| PMS2 | -7130 | -6546 |
| RAD1 | -3429 | -4384 |
| RAD17 | -4981 | -5186 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RAD9A | 3037 | 4622 |
| RBBP8 | 6366 | 897 |
| RFC2 | 5723 | 2278 |
| RFC3 | -1460 | -5790 |
| RFC4 | 6796 | 6946 |
| RFC5 | 2578 | -4853 |
| RHNO1 | 4417 | -1499 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| RPA1 | -4875 | -32 |
| RPA2 | -6223 | -4258 |
| RPA3 | 6219 | -150 |
| SEM1 | 2100 | -1661 |
| TOP3A | 536 | 1949 |
| TOPBP1 | 5609 | 932 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
EML4 and NUDC in mitotic spindle formation
| metric | value |
|---|---|
| setSize | 100 |
| pMANOVA | 2.94e-10 |
| p.adjustMANOVA | 9.52e-09 |
| s.dist | 0.309 |
| s.intact | 0.307 |
| s.torn | 0.0425 |
| p.intact | 1.19e-07 |
| p.torn | 0.463 |
| Gene | intact | torn |
|---|---|---|
| CENPT | 5987 | 6782 |
| TUBB2A | 6868 | 5864 |
| TUBB3 | 6963 | 5440 |
| SEC13 | 5933 | 6119 |
| ZWINT | 7508 | 4600 |
| DYNLL1 | 7367 | 4660 |
| NEK6 | 4744 | 7130 |
| PLK1 | 6019 | 5428 |
| ITGB3BP | 6446 | 4864 |
| CENPF | 7470 | 3944 |
| TUBA1B | 7247 | 3991 |
| AURKB | 7215 | 3842 |
| DSN1 | 7251 | 3631 |
| B9D2 | 5925 | 4121 |
| RCC2 | 6514 | 3607 |
| BUB1B | 6902 | 3288 |
| CENPU | 7143 | 3041 |
| NDEL1 | 5223 | 3922 |
| CDC20 | 6953 | 2869 |
| TUBA1A | 5947 | 3199 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| AHCTF1 | -1868 | -2476 |
| AURKB | 7215 | 3842 |
| B9D2 | 5925 | 4121 |
| BIRC5 | 7504 | -35 |
| BUB1 | 6917 | 1846 |
| BUB1B | 6902 | 3288 |
| BUB3 | 4821 | 3230 |
| CDC20 | 6953 | 2869 |
| CENPC | 5886 | -3995 |
| CENPE | 7455 | 2472 |
| CENPF | 7470 | 3944 |
| CENPH | 2630 | -2732 |
| CENPI | 4264 | 2186 |
| CENPK | 6942 | 2669 |
| CENPL | -73 | 4510 |
| CENPM | 3434 | -7221 |
| CENPN | 7025 | -552 |
| CENPO | 5044 | 1367 |
| CENPP | 3967 | 1210 |
| CENPQ | -900 | -5156 |
| CENPT | 5987 | 6782 |
| CENPU | 7143 | 3041 |
| CKAP5 | -2281 | -3640 |
| CLASP1 | -8168 | -5847 |
| CLASP2 | -7243 | -6164 |
| CLIP1 | -7034 | -7091 |
| DSN1 | 7251 | 3631 |
| DYNC1H1 | -2588 | -2225 |
| DYNC1I1 | -7524 | -8372 |
| DYNC1I2 | 7346 | 1786 |
| DYNC1LI1 | -4750 | -6066 |
| DYNC1LI2 | 2085 | 7232 |
| DYNLL1 | 7367 | 4660 |
| DYNLL2 | -7843 | -5968 |
| EML4 | 4990 | 1206 |
| INCENP | 462 | 6309 |
| ITGB3BP | 6446 | 4864 |
| KIF2A | 5803 | 560 |
| KIF2C | 7456 | 1988 |
| KNL1 | 3670 | 923 |
| KNTC1 | 7234 | 1447 |
| MAD1L1 | 4218 | 4048 |
| MAD2L1 | 5383 | 80 |
| MAPRE1 | 6255 | 2175 |
| MIS12 | -4782 | -2902 |
| NDC80 | 7467 | -2392 |
| NDE1 | 3097 | 623 |
| NDEL1 | 5223 | 3922 |
| NEK6 | 4744 | 7130 |
| NEK7 | -4690 | -2018 |
| NEK9 | -7391 | -2936 |
| NSL1 | -478 | -1439 |
| NUDC | -2830 | -3360 |
| NUF2 | 7336 | 1899 |
| NUP107 | 5578 | 107 |
| NUP133 | -6373 | -3983 |
| NUP160 | 399 | -2337 |
| NUP37 | 1446 | -1552 |
| NUP43 | -5006 | -5784 |
| NUP85 | 5698 | 1531 |
| NUP98 | -6242 | -5221 |
| PAFAH1B1 | -5396 | -2624 |
| PLK1 | 6019 | 5428 |
| PMF1 | -6638 | -3176 |
| PPP1CC | -723 | -2464 |
| PPP2CA | -5147 | -4250 |
| PPP2CB | -3417 | -5559 |
| PPP2R1A | -6465 | -4354 |
| PPP2R1B | -196 | 179 |
| PPP2R5A | -7766 | -5250 |
| PPP2R5B | 1129 | 5974 |
| PPP2R5C | 954 | -3354 |
| PPP2R5D | -6774 | -3261 |
| PPP2R5E | -414 | -5215 |
| RANBP2 | -2738 | -1042 |
| RANGAP1 | 3694 | -1800 |
| RCC2 | 6514 | 3607 |
| RPS27 | 1993 | 6981 |
| SEC13 | 5933 | 6119 |
| SEH1L | 2378 | 35 |
| SGO2 | 6905 | 1342 |
| SKA1 | 2798 | -2595 |
| SKA2 | 3713 | -1752 |
| SPC24 | 6206 | -1243 |
| SPDL1 | 5457 | -2599 |
| TAOK1 | 3854 | 2554 |
| TUBA1A | 5947 | 3199 |
| TUBA1B | 7247 | 3991 |
| TUBA1C | 6988 | 2404 |
| TUBA4A | -8494 | -7581 |
| TUBA8 | -8458 | -6784 |
| TUBB2A | 6868 | 5864 |
| TUBB2B | -2347 | 7708 |
| TUBB3 | 6963 | 5440 |
| TUBB4B | 5934 | -1928 |
| TUBB6 | 7063 | 2423 |
| XPO1 | -2792 | -156 |
| ZW10 | -1065 | -465 |
| ZWILCH | 5450 | 1870 |
| ZWINT | 7508 | 4600 |
Pyruvate metabolism
| metric | value |
|---|---|
| setSize | 27 |
| pMANOVA | 0.000158 |
| p.adjustMANOVA | 0.00117 |
| s.dist | 0.465 |
| s.intact | -0.432 |
| s.torn | -0.171 |
| p.intact | 0.000102 |
| p.torn | 0.125 |
| Gene | intact | torn |
|---|---|---|
| PDHX | -8084 | -6771 |
| PDK2 | -8334 | -6172 |
| LDHB | -7904 | -6486 |
| DLAT | -7750 | -6218 |
| PDHB | -7226 | -6667 |
| GLO1 | -7174 | -6671 |
| HAGH | -7118 | -6233 |
| MPC1 | -7211 | -6064 |
| DLD | -7856 | -5437 |
| VDAC1 | -7456 | -5675 |
| MPC2 | -6445 | -6388 |
| PDHA1 | -7678 | -4488 |
| GSTZ1 | -5665 | -5879 |
| PDP2 | -4556 | -4957 |
| PDP1 | -6550 | -1562 |
| PDK4 | -8361 | -1219 |
| ME1 | -2190 | -1491 |
| RXRA | -5323 | -542 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| BSG | -2135 | 4200 |
| DLAT | -7750 | -6218 |
| DLD | -7856 | -5437 |
| GLO1 | -7174 | -6671 |
| GSTZ1 | -5665 | -5879 |
| HAGH | -7118 | -6233 |
| LDHA | 3772 | 4577 |
| LDHB | -7904 | -6486 |
| ME1 | -2190 | -1491 |
| MPC1 | -7211 | -6064 |
| MPC2 | -6445 | -6388 |
| PDHA1 | -7678 | -4488 |
| PDHB | -7226 | -6667 |
| PDHX | -8084 | -6771 |
| PDK1 | 3534 | 7572 |
| PDK2 | -8334 | -6172 |
| PDK3 | 6056 | 3735 |
| PDK4 | -8361 | -1219 |
| PDP1 | -6550 | -1562 |
| PDP2 | -4556 | -4957 |
| PDPR | -2757 | 1925 |
| PPARD | -3103 | 7138 |
| RXRA | -5323 | -542 |
| SLC16A1 | -923 | 5913 |
| SLC16A3 | 7045 | 7339 |
| SLC16A8 | 2240 | 1231 |
| VDAC1 | -7456 | -5675 |
Resolution of D-loop Structures through Holliday Junction Intermediates
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 2.74e-05 |
| p.adjustMANOVA | 0.000293 |
| s.dist | 0.472 |
| s.intact | 0.437 |
| s.torn | 0.177 |
| p.intact | 1.88e-05 |
| p.torn | 0.0825 |
| Gene | intact | torn |
|---|---|---|
| EME1 | 7441 | 5401 |
| BRCA2 | 7330 | 5376 |
| ATM | 3410 | 6501 |
| SLX1A | 6053 | 3440 |
| RMI2 | 6274 | 3247 |
| MRE11 | 4777 | 4133 |
| RAD51 | 6376 | 2623 |
| SPIDR | 2204 | 6577 |
| BRCA1 | 3736 | 3627 |
| RBBP8 | 6366 | 897 |
| XRCC3 | 1650 | 3107 |
| RAD50 | 3782 | 936 |
| EME2 | 2126 | 1454 |
| SLX4 | 830 | 3659 |
| RAD51D | 5820 | 270 |
| DNA2 | 658 | 1898 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ATM | 3410 | 6501 |
| BARD1 | -2077 | -7428 |
| BLM | 6533 | -1385 |
| BRCA1 | 3736 | 3627 |
| BRCA2 | 7330 | 5376 |
| BRIP1 | 4824 | -1548 |
| DNA2 | 658 | 1898 |
| EME1 | 7441 | 5401 |
| EME2 | 2126 | 1454 |
| GEN1 | 4979 | -2190 |
| KAT5 | 180 | -266 |
| MRE11 | 4777 | 4133 |
| MUS81 | -3206 | 2875 |
| NBN | 81 | -1834 |
| PALB2 | 3814 | -1455 |
| RAD50 | 3782 | 936 |
| RAD51 | 6376 | 2623 |
| RAD51AP1 | 7483 | -424 |
| RAD51B | -2272 | 380 |
| RAD51C | -613 | 105 |
| RAD51D | 5820 | 270 |
| RBBP8 | 6366 | 897 |
| RMI1 | -2518 | -2145 |
| RMI2 | 6274 | 3247 |
| SEM1 | 2100 | -1661 |
| SLX1A | 6053 | 3440 |
| SLX4 | 830 | 3659 |
| SPIDR | 2204 | 6577 |
| TOP3A | 536 | 1949 |
| WRN | 2229 | 116 |
| XRCC2 | 4275 | -1957 |
| XRCC3 | 1650 | 3107 |
Sulfur amino acid metabolism
| metric | value |
|---|---|
| setSize | 25 |
| pMANOVA | 0.00102 |
| p.adjustMANOVA | 0.0053 |
| s.dist | 0.409 |
| s.intact | -0.387 |
| s.torn | -0.132 |
| p.intact | 0.000804 |
| p.torn | 0.255 |
| Gene | intact | torn |
|---|---|---|
| GADL1 | -8427 | -6974 |
| GOT1 | -8403 | -6630 |
| GOT2 | -8232 | -6188 |
| MTRR | -6250 | -6375 |
| TXN2 | -7256 | -5418 |
| APIP | -6745 | -4986 |
| ADI1 | -5787 | -5593 |
| TST | -7517 | -4182 |
| SUOX | -8048 | -3636 |
| FMO1 | -6999 | -3346 |
| BHMT2 | -6175 | -3352 |
| AHCY | -5236 | -3821 |
| TSTD1 | -6275 | -2811 |
| SLC25A10 | -5385 | -1069 |
| ADO | -306 | -788 |
Click HERE to show all gene set members
| intact | torn | |
|---|---|---|
| ADI1 | -5787 | -5593 |
| ADO | -306 | -788 |
| AHCY | -5236 | -3821 |
| APIP | -6745 | -4986 |
| BHMT2 | -6175 | -3352 |
| CBS | 6302 | 6935 |
| CDO1 | 2620 | 4283 |
| CSAD | -403 | 5551 |
| CTH | -4264 | 607 |
| ENOPH1 | 4700 | 1211 |
| ETHE1 | 3933 | 1874 |
| FMO1 | -6999 | -3346 |
| GADL1 | -8427 | -6974 |
| GOT1 | -8403 | -6630 |
| GOT2 | -8232 | -6188 |
| MPST | -6733 | 1705 |
| MRI1 | 330 | 5070 |
| MTAP | 2760 | 32 |
| MTR | -4233 | 3869 |
| MTRR | -6250 | -6375 |
| SLC25A10 | -5385 | -1069 |
| SUOX | -8048 | -3636 |
| TST | -7517 | -4182 |
| TSTD1 | -6275 | -2811 |
| TXN2 | -7256 | -5418 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
##
## locale:
## [1] LC_CTYPE=en_AU.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_AU.UTF-8 LC_COLLATE=en_AU.UTF-8
## [5] LC_MONETARY=en_AU.UTF-8 LC_MESSAGES=en_AU.UTF-8
## [7] LC_PAPER=en_AU.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C
##
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] pkgload_1.3.3 GGally_2.2.0
## [3] beeswarm_0.4.0 gtools_3.9.5
## [5] echarts4r_0.4.5 kableExtra_1.3.4
## [7] topconfects_1.18.0 limma_3.58.1
## [9] eulerr_7.0.0 mitch_1.14.0
## [11] MASS_7.3-60 fgsea_1.28.0
## [13] gplots_3.1.3 DESeq2_1.42.0
## [15] SummarizedExperiment_1.32.0 Biobase_2.62.0
## [17] MatrixGenerics_1.14.0 matrixStats_1.2.0
## [19] GenomicRanges_1.54.1 GenomeInfoDb_1.38.5
## [21] IRanges_2.36.0 S4Vectors_0.40.2
## [23] BiocGenerics_0.48.1 reshape2_1.4.4
## [25] lubridate_1.9.3 forcats_1.0.0
## [27] stringr_1.5.1 dplyr_1.1.4
## [29] purrr_1.0.2 readr_2.1.4
## [31] tidyr_1.3.0 tibble_3.2.1
## [33] ggplot2_3.4.4 tidyverse_2.0.0
## [35] zoo_1.8-12 R.utils_2.12.3
## [37] R.oo_1.25.0 R.methodsS3_1.8.2
##
## loaded via a namespace (and not attached):
## [1] bitops_1.0-7 gridExtra_2.3 rlang_1.1.2
## [4] magrittr_2.0.3 compiler_4.3.2 systemfonts_1.0.5
## [7] vctrs_0.6.5 rvest_1.0.3 pkgconfig_2.0.3
## [10] crayon_1.5.2 fastmap_1.1.1 XVector_0.42.0
## [13] ellipsis_0.3.2 labeling_0.4.3 caTools_1.18.2
## [16] utf8_1.2.4 promises_1.2.1 rmarkdown_2.25
## [19] tzdb_0.4.0 xfun_0.41 cachem_1.0.8
## [22] zlibbioc_1.48.0 jsonlite_1.8.8 highr_0.10
## [25] later_1.3.2 DelayedArray_0.28.0 BiocParallel_1.36.0
## [28] parallel_4.3.2 R6_2.5.1 bslib_0.6.1
## [31] stringi_1.8.3 RColorBrewer_1.1-3 jquerylib_0.1.4
## [34] assertthat_0.2.1 Rcpp_1.0.11 knitr_1.45
## [37] httpuv_1.6.13 Matrix_1.6-4 timechange_0.2.0
## [40] tidyselect_1.2.0 yaml_2.3.8 rstudioapi_0.15.0
## [43] abind_1.4-5 codetools_0.2-19 lattice_0.22-5
## [46] plyr_1.8.9 shiny_1.8.0 withr_2.5.2
## [49] evaluate_0.23 ggstats_0.5.1 xml2_1.3.6
## [52] pillar_1.9.0 KernSmooth_2.23-22 generics_0.1.3
## [55] RCurl_1.98-1.13 hms_1.1.3 munsell_0.5.0
## [58] scales_1.3.0 xtable_1.8-4 glue_1.6.2
## [61] tools_4.3.2 data.table_1.14.10 webshot_0.5.5
## [64] locfit_1.5-9.8 fastmatch_1.1-4 cowplot_1.1.2
## [67] grid_4.3.2 colorspace_2.1-0 GenomeInfoDbData_1.2.11
## [70] cli_3.6.2 fansi_1.0.6 viridisLite_0.4.2
## [73] S4Arrays_1.2.0 svglite_2.1.3 gtable_0.3.4
## [76] sass_0.4.8 digest_0.6.33 SparseArray_1.2.3
## [79] farver_2.1.1 htmlwidgets_1.6.4 htmltools_0.5.7
## [82] lifecycle_1.0.4 httr_1.4.7 statmod_1.5.0
## [85] mime_0.12END of report