date generated: 2024-04-09

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
rna k9a
HSPA1A 103.91955 1.9187698
NR4A3 68.07237 10.7310014
HSPA1B 47.19114 18.8135158
DNAJB1 35.12799 2.4326980
MIR133A1HG -27.36199 8.9061962
KLF2 26.52373 0.4202366

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 13119
duplicated_genes_present 0
num_profile_genes_in_sets 6521
num_profile_genes_not_in_sets 6598
profile_pearson_correl 0.1324
profile_spearman_correl 0.13759

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: ReactomePathways.gmt
Gene set metrics
Gene sets metrics
num_genesets 2263
num_genesets_excluded 1062
num_genesets_included 1201

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 522

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 16 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.rna s.k9a p.rna p.k9a
Signal Transduction 1466 1.77e-37 2.13e-34 0.220 0.1820 0.1240 4.30e-30 9.09e-15
Metabolism of RNA 545 1.74e-26 1.04e-23 0.256 -0.1420 0.2130 1.71e-08 3.20e-17
Translation 228 1.28e-25 5.13e-23 0.390 -0.3620 0.1450 5.01e-21 1.77e-04
Regulation of expression of SLITs and ROBOs 125 2.44e-22 7.34e-20 0.490 -0.4580 0.1730 8.97e-19 8.49e-04
Viral mRNA Translation 62 1.39e-20 3.34e-18 0.687 -0.6840 0.0611 1.16e-20 4.06e-01
Peptide chain elongation 63 2.43e-20 4.87e-18 0.675 -0.6720 0.0725 2.86e-20 3.20e-01
Eukaryotic Translation Elongation 66 4.13e-20 7.08e-18 0.656 -0.6520 0.0716 4.91e-20 3.15e-01
Selenocysteine synthesis 67 5.23e-20 7.85e-18 0.650 -0.6460 0.0667 5.40e-20 3.46e-01
SRP-dependent cotranslational protein targeting to membrane 81 8.57e-20 1.14e-17 0.582 -0.5730 0.1030 4.61e-19 1.08e-01
Immune System 1306 3.94e-19 4.73e-17 0.165 0.1230 0.1100 2.64e-13 6.28e-11
Formation of a pool of free 40S subunits 74 1.64e-18 1.79e-16 0.593 -0.5890 0.0686 1.85e-18 3.08e-01
Cap-dependent Translation Initiation 91 2.31e-18 2.14e-16 0.529 -0.5210 0.0915 8.58e-18 1.32e-01
Eukaryotic Translation Initiation 91 2.31e-18 2.14e-16 0.529 -0.5210 0.0915 8.58e-18 1.32e-01
Eukaryotic Translation Termination 66 3.24e-18 2.78e-16 0.622 -0.6160 0.0805 4.64e-18 2.58e-01
Selenoamino acid metabolism 86 1.03e-17 8.22e-16 0.537 -0.5320 0.0715 1.48e-17 2.52e-01
Gene expression (Transcription) 1120 2.70e-17 2.03e-15 0.165 0.0679 0.1500 1.67e-04 8.60e-17


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.rna s.k9a p.rna p.k9a
Signal Transduction 1466 1.77e-37 2.13e-34 0.22000 0.182000 0.124000 4.30e-30 9.09e-15
Metabolism of RNA 545 1.74e-26 1.04e-23 0.25600 -0.142000 0.213000 1.71e-08 3.20e-17
Translation 228 1.28e-25 5.13e-23 0.39000 -0.362000 0.145000 5.01e-21 1.77e-04
Regulation of expression of SLITs and ROBOs 125 2.44e-22 7.34e-20 0.49000 -0.458000 0.173000 8.97e-19 8.49e-04
Viral mRNA Translation 62 1.39e-20 3.34e-18 0.68700 -0.684000 0.061100 1.16e-20 4.06e-01
Peptide chain elongation 63 2.43e-20 4.87e-18 0.67500 -0.672000 0.072500 2.86e-20 3.20e-01
Eukaryotic Translation Elongation 66 4.13e-20 7.08e-18 0.65600 -0.652000 0.071600 4.91e-20 3.15e-01
Selenocysteine synthesis 67 5.23e-20 7.85e-18 0.65000 -0.646000 0.066700 5.40e-20 3.46e-01
SRP-dependent cotranslational protein targeting to membrane 81 8.57e-20 1.14e-17 0.58200 -0.573000 0.103000 4.61e-19 1.08e-01
Immune System 1306 3.94e-19 4.73e-17 0.16500 0.123000 0.110000 2.64e-13 6.28e-11
Formation of a pool of free 40S subunits 74 1.64e-18 1.79e-16 0.59300 -0.589000 0.068600 1.85e-18 3.08e-01
Cap-dependent Translation Initiation 91 2.31e-18 2.14e-16 0.52900 -0.521000 0.091500 8.58e-18 1.32e-01
Eukaryotic Translation Initiation 91 2.31e-18 2.14e-16 0.52900 -0.521000 0.091500 8.58e-18 1.32e-01
Eukaryotic Translation Termination 66 3.24e-18 2.78e-16 0.62200 -0.616000 0.080500 4.64e-18 2.58e-01
Selenoamino acid metabolism 86 1.03e-17 8.22e-16 0.53700 -0.532000 0.071500 1.48e-17 2.52e-01
Gene expression (Transcription) 1120 2.70e-17 2.03e-15 0.16500 0.067900 0.150000 1.67e-04 8.60e-17
GTP hydrolysis and joining of the 60S ribosomal subunit 84 6.80e-17 4.80e-15 0.52800 -0.522000 0.081900 1.34e-16 1.95e-01
L13a-mediated translational silencing of Ceruloplasmin expression 83 7.78e-17 5.19e-15 0.52800 -0.518000 0.103000 3.51e-16 1.05e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 69 1.90e-16 1.20e-14 0.57600 -0.571000 0.076900 2.32e-16 2.70e-01
Diseases of signal transduction 288 6.22e-16 3.74e-14 0.30400 0.161000 0.258000 3.04e-06 5.59e-14
Metabolism of proteins 1426 1.17e-15 6.70e-14 0.13200 -0.005590 0.132000 7.30e-01 3.39e-16
Signaling by ROBO receptors 163 1.31e-15 7.17e-14 0.35200 -0.303000 0.179000 2.55e-11 8.49e-05
Cytokine Signaling in Immune system 551 4.16e-15 2.17e-13 0.21700 0.180000 0.121000 7.75e-13 1.59e-06
RNA Polymerase II Transcription 1005 5.37e-15 2.63e-13 0.16000 0.065700 0.146000 5.21e-04 1.06e-14
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 75 5.61e-15 2.63e-13 0.50400 -0.411000 0.292000 7.51e-10 1.29e-05
Post-translational protein modification 1023 5.70e-15 2.63e-13 0.16000 0.072200 0.143000 1.23e-04 3.22e-14
Metabolism 1414 9.36e-15 4.16e-13 0.12100 -0.086200 0.085200 1.12e-07 1.59e-07
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 88 1.33e-14 5.52e-13 0.46800 -0.439000 0.161000 1.07e-12 9.03e-03
Nonsense-Mediated Decay (NMD) 88 1.33e-14 5.52e-13 0.46800 -0.439000 0.161000 1.07e-12 9.03e-03
Respiratory electron transport 71 1.98e-14 7.94e-13 0.50800 -0.420000 0.286000 9.30e-10 3.11e-05
The citric acid (TCA) cycle and respiratory electron transport 119 2.24e-14 8.69e-13 0.39100 -0.270000 0.283000 3.77e-07 1.02e-07
Antigen processing: Ubiquitination & Proteasome degradation 259 6.89e-14 2.59e-12 0.28900 0.076100 0.279000 3.57e-02 1.22e-14
Class I MHC mediated antigen processing & presentation 304 7.91e-14 2.88e-12 0.27000 0.095400 0.253000 4.41e-03 4.39e-14
Cellular responses to external stimuli 337 8.99e-14 3.17e-12 0.25200 0.059400 0.245000 6.24e-02 1.27e-14
Cellular responses to stress 332 9.83e-14 3.37e-12 0.25300 0.052000 0.247000 1.05e-01 1.17e-14
Membrane Trafficking 477 1.22e-13 4.07e-12 0.21900 0.111000 0.189000 3.48e-05 2.36e-12
ESR-mediated signaling 134 2.58e-13 8.37e-12 0.40700 0.288000 0.287000 8.78e-09 1.02e-08
Signaling by Nuclear Receptors 191 3.73e-13 1.18e-11 0.33900 0.217000 0.261000 2.63e-07 5.83e-10
Adaptive Immune System 512 5.04e-13 1.55e-11 0.20600 0.096300 0.182000 2.16e-04 2.59e-12
rRNA processing 149 8.24e-13 2.47e-11 0.33800 -0.323000 0.099500 1.03e-11 3.64e-02
Vesicle-mediated transport 500 2.04e-12 5.99e-11 0.20500 0.117000 0.168000 8.43e-06 1.72e-10
mRNA Splicing 159 2.55e-12 7.29e-11 0.31900 -0.111000 0.299000 1.60e-02 8.08e-11
Influenza Viral RNA Transcription and Replication 102 3.48e-12 9.54e-11 0.40400 -0.398000 0.066100 3.80e-12 2.49e-01
Generic Transcription Pathway 903 3.49e-12 9.54e-11 0.15200 0.071400 0.134000 3.34e-04 1.50e-11
Mitochondrial translation initiation 63 3.85e-12 1.03e-10 0.49800 -0.453000 0.206000 5.01e-10 4.64e-03
Metabolism of amino acids and derivatives 255 4.38e-12 1.14e-10 0.25700 -0.255000 0.032800 2.86e-12 3.70e-01
Chromatin modifying enzymes 186 7.66e-12 1.92e-10 0.32100 0.157000 0.281000 2.38e-04 4.57e-11
Chromatin organization 186 7.66e-12 1.92e-10 0.32100 0.157000 0.281000 2.38e-04 4.57e-11
rRNA processing in the nucleus and cytosol 142 7.82e-12 1.92e-10 0.33300 -0.322000 0.086900 3.76e-11 7.46e-02
Processing of Capped Intron-Containing Pre-mRNA 205 9.33e-12 2.24e-10 0.27400 -0.096700 0.257000 1.73e-02 2.54e-10
Mitochondrial translation termination 63 1.25e-11 2.93e-10 0.48700 -0.443000 0.202000 1.24e-09 5.56e-03
Major pathway of rRNA processing in the nucleolus and cytosol 136 1.67e-11 3.87e-10 0.33700 -0.329000 0.073600 3.64e-11 1.39e-01
Extracellular matrix organization 189 2.41e-11 5.47e-10 0.27500 0.168000 -0.218000 6.92e-05 2.69e-07
Infectious disease 296 3.01e-11 6.67e-10 0.21900 -0.148000 0.162000 1.28e-05 1.87e-06
mRNA Splicing - Major Pathway 154 3.05e-11 6.67e-10 0.31000 -0.096000 0.295000 4.03e-02 2.93e-10
Mitochondrial translation elongation 62 3.31e-11 7.11e-10 0.47900 -0.424000 0.222000 7.60e-09 2.51e-03
FOXO-mediated transcription 52 3.66e-11 7.71e-10 0.59000 0.335000 0.485000 3.00e-05 1.41e-09
Circadian Clock 62 4.87e-11 1.01e-09 0.53700 0.301000 0.444000 4.22e-05 1.44e-09
PIP3 activates AKT signaling 212 5.68e-11 1.16e-09 0.28600 0.111000 0.264000 5.67e-03 3.91e-11
Estrogen-dependent gene expression 81 6.35e-11 1.27e-09 0.47000 0.306000 0.356000 1.93e-06 3.14e-08
Mitochondrial translation 68 6.81e-11 1.34e-09 0.45000 -0.397000 0.213000 1.56e-08 2.42e-03
Disease 758 8.29e-11 1.61e-09 0.14800 0.015200 0.147000 4.82e-01 9.77e-12
Deubiquitination 211 9.50e-11 1.81e-09 0.28300 0.107000 0.263000 7.72e-03 5.53e-11
Neddylation 192 9.84e-11 1.85e-09 0.28300 0.006130 0.283000 8.84e-01 1.56e-11
Complex I biogenesis 37 1.17e-10 2.16e-09 0.60700 -0.561000 0.232000 3.49e-09 1.45e-02
Signaling by Receptor Tyrosine Kinases 332 2.87e-10 5.23e-09 0.22600 0.177000 0.141000 3.55e-08 1.07e-05
Influenza Life Cycle 110 3.27e-10 5.87e-09 0.34900 -0.334000 0.099600 1.46e-09 7.16e-02
Signaling by TGF-beta family members 90 3.68e-10 6.49e-09 0.42900 0.310000 0.297000 3.96e-07 1.14e-06
Signaling by WNT 203 4.95e-10 8.61e-09 0.27200 0.055500 0.266000 1.74e-01 6.59e-11
Intracellular signaling by second messengers 246 5.53e-10 9.48e-09 0.25300 0.103000 0.232000 5.53e-03 4.51e-10
Interleukin-4 and Interleukin-13 signaling 64 1.04e-09 1.76e-08 0.47300 0.464000 0.093100 1.37e-10 1.98e-01
Apoptosis 140 1.05e-09 1.76e-08 0.31900 0.047100 0.315000 3.37e-01 1.28e-10
Developmental Biology 578 1.14e-09 1.87e-08 0.16500 0.073100 0.148000 2.91e-03 1.54e-09
Programmed Cell Death 142 1.30e-09 2.11e-08 0.31600 0.055400 0.311000 2.56e-01 1.64e-10
Ub-specific processing proteases 144 1.52e-09 2.43e-08 0.31700 0.088900 0.304000 6.62e-02 3.04e-10
Downstream signaling events of B Cell Receptor (BCR) 68 2.67e-09 4.22e-08 0.41300 -0.204000 0.359000 3.70e-03 3.09e-07
MAPK family signaling cascades 211 3.32e-09 5.18e-08 0.26300 0.125000 0.232000 1.74e-03 7.23e-09
Signaling by Interleukins 292 5.05e-09 7.77e-08 0.22400 0.181000 0.132000 1.09e-07 1.13e-04
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 57 9.34e-09 1.40e-07 0.43300 -0.321000 0.290000 2.76e-05 1.55e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 57 9.34e-09 1.40e-07 0.43300 -0.321000 0.290000 2.76e-05 1.55e-04
HSP90 chaperone cycle for steroid hormone receptors (SHR) 33 1.17e-08 1.73e-07 0.64800 0.478000 0.437000 1.98e-06 1.38e-05
Influenza Infection 120 1.23e-08 1.80e-07 0.30600 -0.294000 0.083200 2.77e-08 1.16e-01
Autodegradation of Cdh1 by Cdh1:APC/C 55 1.36e-08 1.97e-07 0.43600 -0.335000 0.279000 1.73e-05 3.46e-04
DNA Replication 97 1.79e-08 2.56e-07 0.33000 -0.294000 0.150000 5.89e-07 1.06e-02
Synthesis of DNA 94 2.20e-08 3.11e-07 0.33400 -0.304000 0.138000 3.47e-07 2.06e-02
APC/C:Cdc20 mediated degradation of Securin 55 2.25e-08 3.14e-07 0.43000 -0.321000 0.286000 3.84e-05 2.48e-04
Signaling by TGF-beta Receptor Complex 66 2.33e-08 3.21e-07 0.45000 0.295000 0.340000 3.50e-05 1.82e-06
APC/C:Cdc20 mediated degradation of mitotic proteins 58 2.40e-08 3.27e-07 0.41800 -0.309000 0.281000 4.62e-05 2.19e-04
GLI3 is processed to GLI3R by the proteasome 51 2.44e-08 3.30e-07 0.44500 -0.312000 0.317000 1.17e-04 8.85e-05
Host Interactions of HIV factors 109 2.53e-08 3.37e-07 0.30600 -0.180000 0.247000 1.19e-03 8.51e-06
Transcriptional regulation by RUNX1 149 2.88e-08 3.80e-07 0.29300 0.119000 0.268000 1.25e-02 1.80e-08
PTEN Regulation 126 2.93e-08 3.82e-07 0.30500 0.026600 0.304000 6.07e-01 4.04e-09
CLEC7A (Dectin-1) signaling 83 2.98e-08 3.84e-07 0.35600 -0.115000 0.337000 7.15e-02 1.15e-07
Switching of origins to a post-replicative state 70 3.01e-08 3.84e-07 0.37900 -0.312000 0.216000 6.32e-06 1.84e-03
FCERI mediated NF-kB activation 67 3.18e-08 4.02e-07 0.39000 -0.181000 0.345000 1.05e-02 1.03e-06
Activation of NF-kappaB in B cells 55 3.29e-08 4.12e-07 0.42500 -0.274000 0.325000 4.42e-04 3.02e-05
TCF dependent signaling in response to WNT 137 3.36e-08 4.16e-07 0.29300 0.033900 0.291000 4.95e-01 4.48e-09
Orc1 removal from chromatin 54 3.70e-08 4.54e-07 0.43100 -0.371000 0.218000 2.38e-06 5.53e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 59 4.22e-08 5.12e-07 0.40800 -0.311000 0.264000 3.71e-05 4.53e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 46 4.26e-08 5.12e-07 0.46200 -0.371000 0.276000 1.33e-05 1.23e-03
Degradation of DVL 48 4.63e-08 5.51e-07 0.45000 -0.314000 0.323000 1.70e-04 1.09e-04
Regulation of APC/C activators between G1/S and early anaphase 64 5.33e-08 6.28e-07 0.38900 -0.283000 0.266000 8.95e-05 2.35e-04
DNA Replication Pre-Initiation 63 6.30e-08 7.35e-07 0.39300 -0.342000 0.194000 2.69e-06 7.89e-03
Signaling by Rho GTPases 284 7.09e-08 8.19e-07 0.21100 0.176000 0.116000 3.83e-07 8.26e-04
RHO GTPase Effectors 180 7.43e-08 8.49e-07 0.26400 0.164000 0.207000 1.47e-04 1.82e-06
Vif-mediated degradation of APOBEC3G 43 7.57e-08 8.57e-07 0.46900 -0.362000 0.298000 3.97e-05 7.19e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 57 7.66e-08 8.60e-07 0.40800 -0.316000 0.258000 3.75e-05 7.67e-04
Cellular response to hypoxia 60 8.68e-08 9.66e-07 0.40000 -0.188000 0.353000 1.19e-02 2.35e-06
Degradation of GLI1 by the proteasome 50 9.35e-08 1.03e-06 0.43200 -0.292000 0.318000 3.52e-04 9.98e-05
Regulation of mRNA stability by proteins that bind AU-rich elements 77 9.73e-08 1.06e-06 0.36300 -0.058400 0.359000 3.76e-01 5.40e-08
Degradation of GLI2 by the proteasome 51 1.14e-07 1.24e-06 0.42500 -0.302000 0.299000 1.92e-04 2.20e-04
APC/C-mediated degradation of cell cycle proteins 65 1.20e-07 1.27e-06 0.37600 -0.265000 0.267000 2.17e-04 2.04e-04
Regulation of mitotic cell cycle 65 1.20e-07 1.27e-06 0.37600 -0.265000 0.267000 2.17e-04 2.04e-04
MyD88-independent TLR4 cascade 84 1.28e-07 1.34e-06 0.37900 0.241000 0.292000 1.36e-04 3.68e-06
TRIF(TICAM1)-mediated TLR4 signaling 84 1.28e-07 1.34e-06 0.37900 0.241000 0.292000 1.36e-04 3.68e-06
Transcriptional Regulation by TP53 292 1.43e-07 1.48e-06 0.19900 0.072200 0.186000 3.45e-02 5.27e-08
Negative regulation of NOTCH4 signaling 48 1.47e-07 1.51e-06 0.43500 -0.340000 0.272000 4.63e-05 1.13e-03
CDK-mediated phosphorylation and removal of Cdc6 57 1.66e-07 1.69e-06 0.39800 -0.299000 0.262000 9.51e-05 6.24e-04
Toll Like Receptor 3 (TLR3) Cascade 82 1.83e-07 1.85e-06 0.37800 0.222000 0.307000 5.31e-04 1.63e-06
Signaling by the B Cell Receptor (BCR) 89 2.06e-07 2.06e-06 0.31700 -0.184000 0.258000 2.66e-03 2.60e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 55 2.12e-07 2.09e-06 0.40200 -0.252000 0.313000 1.23e-03 5.96e-05
TP53 Regulates Metabolic Genes 70 2.13e-07 2.09e-06 0.38000 0.004260 0.380000 9.51e-01 3.83e-08
Hedgehog ligand biogenesis 49 2.14e-07 2.09e-06 0.42500 -0.321000 0.279000 1.01e-04 7.35e-04
Assembly of the pre-replicative complex 53 2.47e-07 2.39e-06 0.40900 -0.346000 0.218000 1.29e-05 6.09e-03
Regulation of RUNX2 expression and activity 59 2.67e-07 2.57e-06 0.39100 -0.156000 0.359000 3.89e-02 1.88e-06
Fc epsilon receptor (FCERI) signaling 109 2.72e-07 2.57e-06 0.29900 -0.024900 0.298000 6.53e-01 8.04e-08
Hh mutants abrogate ligand secretion 46 2.74e-07 2.57e-06 0.43500 -0.311000 0.304000 2.60e-04 3.65e-04
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 46 2.74e-07 2.57e-06 0.43500 -0.311000 0.304000 2.60e-04 3.65e-04
Defective CFTR causes cystic fibrosis 49 2.86e-07 2.66e-06 0.42100 -0.280000 0.315000 7.02e-04 1.39e-04
CDT1 association with the CDC6:ORC:origin complex 46 2.97e-07 2.74e-06 0.43500 -0.337000 0.274000 7.71e-05 1.30e-03
Separation of Sister Chromatids 123 3.09e-07 2.81e-06 0.27600 -0.058300 0.270000 2.65e-01 2.52e-07
Vpu mediated degradation of CD4 44 3.10e-07 2.81e-06 0.44400 -0.342000 0.282000 8.63e-05 1.21e-03
SCF-beta-TrCP mediated degradation of Emi1 46 3.11e-07 2.81e-06 0.43400 -0.327000 0.285000 1.25e-04 8.45e-04
Mitotic Anaphase 133 3.45e-07 3.09e-06 0.26700 -0.036900 0.264000 4.63e-01 1.50e-07
Toll Like Receptor 9 (TLR9) Cascade 80 3.53e-07 3.14e-06 0.37600 0.249000 0.282000 1.22e-04 1.32e-05
HIV Infection 189 3.80e-07 3.36e-06 0.21700 -0.087100 0.199000 3.96e-02 2.59e-06
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 43 3.90e-07 3.37e-06 0.44500 -0.347000 0.279000 8.21e-05 1.57e-03
p53-Independent DNA Damage Response 43 3.90e-07 3.37e-06 0.44500 -0.347000 0.279000 8.21e-05 1.57e-03
p53-Independent G1/S DNA damage checkpoint 43 3.90e-07 3.37e-06 0.44500 -0.347000 0.279000 8.21e-05 1.57e-03
Mitotic Metaphase and Anaphase 134 4.26e-07 3.66e-06 0.26400 -0.033100 0.262000 5.10e-01 1.66e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation 42 4.33e-07 3.69e-06 0.44900 -0.341000 0.291000 1.31e-04 1.09e-03
Dectin-1 mediated noncanonical NF-kB signaling 51 4.43e-07 3.73e-06 0.40800 -0.245000 0.326000 2.53e-03 5.64e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA 47 4.45e-07 3.73e-06 0.42500 -0.247000 0.346000 3.38e-03 4.19e-05
SCF(Skp2)-mediated degradation of p27/p21 47 4.80e-07 4.00e-06 0.42200 -0.304000 0.293000 3.12e-04 5.08e-04
Protein localization 125 5.42e-07 4.49e-06 0.26000 -0.138000 0.221000 7.92e-03 2.06e-05
NIK–>noncanonical NF-kB signaling 50 5.88e-07 4.84e-06 0.40800 -0.246000 0.325000 2.67e-03 6.94e-05
FLT3 Signaling 187 5.92e-07 4.84e-06 0.23600 0.081900 0.222000 5.41e-02 1.85e-07
Transcriptional regulation by RUNX2 96 8.45e-07 6.86e-06 0.31200 0.020100 0.312000 7.34e-01 1.33e-07
Ubiquitin-dependent degradation of Cyclin D 44 8.65e-07 6.97e-06 0.42800 -0.317000 0.287000 2.75e-04 9.88e-04
Regulation of Apoptosis 45 1.00e-06 8.01e-06 0.42100 -0.291000 0.304000 7.26e-04 4.30e-04
Regulation of PTEN stability and activity 58 1.02e-06 8.13e-06 0.37500 -0.169000 0.335000 2.63e-02 1.05e-05
Signaling by PDGF 44 1.15e-06 9.10e-06 0.44700 0.446000 -0.032500 3.14e-07 7.09e-01
Degradation of beta-catenin by the destruction complex 73 1.19e-06 9.33e-06 0.33500 -0.123000 0.312000 7.02e-02 4.18e-06
Cell Cycle 430 1.20e-06 9.33e-06 0.14800 0.010200 0.147000 7.20e-01 1.89e-07
Translocation of SLC2A4 (GLUT4) to the plasma membrane 46 1.32e-06 1.02e-05 0.45900 0.150000 0.434000 7.76e-02 3.54e-07
PPARA activates gene expression 97 1.38e-06 1.06e-05 0.32400 0.184000 0.267000 1.79e-03 5.60e-06
ABC-family proteins mediated transport 79 1.42e-06 1.09e-05 0.31400 -0.230000 0.214000 4.18e-04 1.03e-03
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 99 1.45e-06 1.09e-05 0.32100 0.185000 0.262000 1.50e-03 6.87e-06
Formation of the ternary complex, and subsequently, the 43S complex 39 1.45e-06 1.09e-05 0.46100 -0.448000 0.109000 1.30e-06 2.39e-01
Hemostasis 369 1.47e-06 1.11e-05 0.15900 0.158000 0.021300 2.19e-07 4.84e-01
MyD88 dependent cascade initiated on endosome 77 1.67e-06 1.24e-05 0.36300 0.244000 0.269000 2.18e-04 4.71e-05
Toll Like Receptor 7/8 (TLR7/8) Cascade 77 1.67e-06 1.24e-05 0.36300 0.244000 0.269000 2.18e-04 4.71e-05
RUNX1 regulates transcription of genes involved in differentiation of HSCs 63 1.76e-06 1.30e-05 0.35200 -0.169000 0.309000 2.05e-02 2.31e-05
Toll Like Receptor 4 (TLR4) Cascade 103 1.99e-06 1.45e-05 0.31100 0.247000 0.189000 1.50e-05 9.32e-04
Autodegradation of the E3 ubiquitin ligase COP1 44 2.07e-06 1.51e-05 0.41600 -0.342000 0.236000 8.77e-05 6.69e-03
Collagen chain trimerization 28 2.21e-06 1.60e-05 0.56200 -0.075600 -0.557000 4.89e-01 3.34e-07
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 76 2.36e-06 1.70e-05 0.36000 0.239000 0.269000 3.11e-04 5.04e-05
MAPK6/MAPK4 signaling 73 2.58e-06 1.85e-05 0.33600 -0.033500 0.334000 6.22e-01 8.11e-07
Toll-like Receptor Cascades 117 3.13e-06 2.22e-05 0.28800 0.217000 0.188000 5.01e-05 4.43e-04
Degradation of AXIN 46 3.14e-06 2.22e-05 0.39900 -0.281000 0.282000 9.77e-04 9.24e-04
PI3K/AKT Signaling in Cancer 65 3.18e-06 2.24e-05 0.38400 0.301000 0.239000 2.72e-05 8.82e-04
S Phase 129 3.25e-06 2.27e-05 0.23900 -0.155000 0.182000 2.44e-03 3.80e-04
ABC transporter disorders 60 3.59e-06 2.48e-05 0.34700 -0.243000 0.248000 1.15e-03 8.91e-04
FOXO-mediated transcription of cell cycle genes 15 3.60e-06 2.48e-05 0.79500 0.508000 0.611000 6.51e-04 4.13e-05
Transcriptional regulation of white adipocyte differentiation 69 3.64e-06 2.50e-05 0.37100 0.223000 0.296000 1.35e-03 2.17e-05
Cell Cycle Checkpoints 186 4.14e-06 2.82e-05 0.20800 -0.014300 0.208000 7.38e-01 1.09e-06
Regulation of ornithine decarboxylase (ODC) 40 4.57e-06 3.10e-05 0.42200 -0.334000 0.258000 2.63e-04 4.78e-03
Signaling by NOTCH1 65 4.83e-06 3.26e-05 0.37900 0.268000 0.267000 1.86e-04 1.96e-04
MyD88 cascade initiated on plasma membrane 74 4.92e-06 3.26e-05 0.35500 0.232000 0.268000 5.76e-04 6.68e-05
Toll Like Receptor 10 (TLR10) Cascade 74 4.92e-06 3.26e-05 0.35500 0.232000 0.268000 5.76e-04 6.68e-05
Toll Like Receptor 5 (TLR5) Cascade 74 4.92e-06 3.26e-05 0.35500 0.232000 0.268000 5.76e-04 6.68e-05
Stabilization of p53 47 5.02e-06 3.31e-05 0.38700 -0.294000 0.252000 4.94e-04 2.80e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 6.01e-06 3.87e-05 0.45900 0.263000 0.376000 2.91e-03 1.98e-05
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 79 6.02e-06 3.87e-05 0.34100 0.239000 0.243000 2.50e-04 1.91e-04
Toll Like Receptor 2 (TLR2) Cascade 79 6.02e-06 3.87e-05 0.34100 0.239000 0.243000 2.50e-04 1.91e-04
Toll Like Receptor TLR1:TLR2 Cascade 79 6.02e-06 3.87e-05 0.34100 0.239000 0.243000 2.50e-04 1.91e-04
Toll Like Receptor TLR6:TLR2 Cascade 79 6.02e-06 3.87e-05 0.34100 0.239000 0.243000 2.50e-04 1.91e-04
Assembly of collagen fibrils and other multimeric structures 41 6.74e-06 4.30e-05 0.44300 -0.048100 -0.440000 5.95e-01 1.07e-06
Glutathione conjugation 25 7.27e-06 4.62e-05 0.53900 -0.522000 0.136000 6.37e-06 2.40e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 46 7.79e-06 4.92e-05 0.39100 -0.359000 0.153000 2.51e-05 7.22e-02
Cellular Senescence 114 8.54e-06 5.27e-05 0.27900 0.163000 0.226000 2.65e-03 3.19e-05
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 52 8.61e-06 5.27e-05 0.41100 0.228000 0.341000 4.47e-03 2.07e-05
Constitutive Signaling by NOTCH1 PEST Domain Mutants 52 8.61e-06 5.27e-05 0.41100 0.228000 0.341000 4.47e-03 2.07e-05
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 52 8.61e-06 5.27e-05 0.41100 0.228000 0.341000 4.47e-03 2.07e-05
Signaling by NOTCH1 PEST Domain Mutants in Cancer 52 8.61e-06 5.27e-05 0.41100 0.228000 0.341000 4.47e-03 2.07e-05
Signaling by NOTCH1 in Cancer 52 8.61e-06 5.27e-05 0.41100 0.228000 0.341000 4.47e-03 2.07e-05
Translation initiation complex formation 45 9.18e-06 5.60e-05 0.39300 -0.364000 0.148000 2.45e-05 8.59e-02
Transcriptional activation of mitochondrial biogenesis 49 1.03e-05 6.22e-05 0.42000 0.232000 0.350000 4.91e-03 2.33e-05
C-type lectin receptors (CLRs) 102 1.05e-05 6.36e-05 0.26400 -0.060900 0.257000 2.88e-01 7.55e-06
SUMOylation 149 1.13e-05 6.81e-05 0.24200 0.167000 0.175000 4.35e-04 2.36e-04
Class A/1 (Rhodopsin-like receptors) 64 1.21e-05 7.26e-05 0.32000 0.189000 -0.259000 9.00e-03 3.46e-04
MAPK1/MAPK3 signaling 179 1.23e-05 7.32e-05 0.21500 0.075300 0.201000 8.33e-02 3.76e-06
Intrinsic Pathway for Apoptosis 44 1.26e-05 7.44e-05 0.43400 0.189000 0.391000 3.02e-02 7.31e-06
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 1.32e-05 7.79e-05 0.60300 0.311000 0.517000 9.89e-03 1.76e-05
Integrin cell surface interactions 43 1.33e-05 7.80e-05 0.38800 0.253000 -0.295000 4.15e-03 8.34e-04
ER to Golgi Anterograde Transport 114 1.34e-05 7.83e-05 0.26900 0.114000 0.244000 3.65e-02 6.89e-06
Signaling by NTRK1 (TRKA) 69 1.40e-05 8.09e-05 0.35100 0.225000 0.269000 1.22e-03 1.14e-04
Transport to the Golgi and subsequent modification 136 1.40e-05 8.09e-05 0.24700 0.115000 0.219000 2.12e-02 1.06e-05
Metabolism of polyamines 47 1.42e-05 8.15e-05 0.37100 -0.297000 0.223000 4.35e-04 8.31e-03
RAF/MAP kinase cascade 174 1.49e-05 8.53e-05 0.21400 0.059800 0.205000 1.74e-01 3.19e-06
Golgi Associated Vesicle Biogenesis 46 1.56e-05 8.89e-05 0.42600 0.253000 0.343000 2.96e-03 5.81e-05
Downstream signal transduction 27 1.58e-05 8.98e-05 0.54300 0.509000 0.187000 4.64e-06 9.29e-02
Ribosomal scanning and start codon recognition 45 1.69e-05 9.52e-05 0.38500 -0.367000 0.118000 2.10e-05 1.72e-01
MAP kinase activation 60 1.73e-05 9.70e-05 0.37000 0.193000 0.315000 9.70e-03 2.42e-05
Mitotic G1-G1/S phases 114 1.93e-05 1.08e-04 0.23800 -0.109000 0.211000 4.38e-02 1.03e-04
Signaling by NOTCH4 71 2.10e-05 1.17e-04 0.30100 -0.115000 0.279000 9.43e-02 4.96e-05
Cross-presentation of soluble exogenous antigens (endosomes) 39 2.12e-05 1.17e-04 0.40000 -0.327000 0.231000 4.17e-04 1.25e-02
Regulation of RUNX3 expression and activity 46 2.13e-05 1.17e-04 0.36700 -0.260000 0.259000 2.29e-03 2.37e-03
p53-Dependent G1 DNA Damage Response 52 2.20e-05 1.20e-04 0.34500 -0.239000 0.249000 2.88e-03 1.94e-03
p53-Dependent G1/S DNA damage checkpoint 52 2.20e-05 1.20e-04 0.34500 -0.239000 0.249000 2.88e-03 1.94e-03
Mitochondrial biogenesis 67 2.28e-05 1.24e-04 0.34200 0.140000 0.312000 4.80e-02 1.03e-05
G1/S Transition 100 2.35e-05 1.27e-04 0.24900 -0.153000 0.197000 8.43e-03 6.93e-04
Collagen formation 61 2.52e-05 1.36e-04 0.34100 -0.022900 -0.340000 7.57e-01 4.42e-06
Mitochondrial protein import 44 2.64e-05 1.41e-04 0.37300 -0.214000 0.306000 1.41e-02 4.57e-04
Cyclin E associated events during G1/S transition 68 2.80e-05 1.50e-04 0.30100 -0.146000 0.263000 3.71e-02 1.77e-04
Transcriptional regulation by RUNX3 82 2.93e-05 1.56e-04 0.29400 0.036700 0.292000 5.66e-01 4.91e-06
G1/S DNA Damage Checkpoints 54 3.17e-05 1.68e-04 0.33300 -0.224000 0.246000 4.35e-03 1.81e-03
Asymmetric localization of PCP proteins 53 3.36e-05 1.77e-04 0.33500 -0.226000 0.247000 4.49e-03 1.85e-03
Activation of HOX genes during differentiation 50 3.39e-05 1.77e-04 0.39500 0.248000 0.307000 2.41e-03 1.72e-04
Activation of anterior HOX genes in hindbrain development during early embryogenesis 50 3.39e-05 1.77e-04 0.39500 0.248000 0.307000 2.41e-03 1.72e-04
NOTCH1 Intracellular Domain Regulates Transcription 44 3.44e-05 1.79e-04 0.41500 0.182000 0.372000 3.68e-02 1.93e-05
PCP/CE pathway 74 3.55e-05 1.84e-04 0.28400 -0.163000 0.233000 1.56e-02 5.48e-04
Signaling by BMP 24 3.70e-05 1.91e-04 0.56800 0.423000 0.379000 3.39e-04 1.30e-03
The role of GTSE1 in G2/M progression after G2 checkpoint 49 4.17e-05 2.14e-04 0.34500 -0.240000 0.247000 3.72e-03 2.74e-03
Apoptotic execution phase 37 4.41e-05 2.25e-04 0.45300 0.274000 0.360000 3.93e-03 1.50e-04
Cyclin A:Cdk2-associated events at S phase entry 70 4.53e-05 2.30e-04 0.28900 -0.153000 0.245000 2.69e-02 3.93e-04
Cell Cycle, Mitotic 355 4.61e-05 2.34e-04 0.13700 -0.005760 0.137000 8.53e-01 1.10e-05
TGF-beta receptor signaling activates SMADs 30 5.21e-05 2.63e-04 0.49800 0.294000 0.402000 5.41e-03 1.38e-04
Extra-nuclear estrogen signaling 56 5.51e-05 2.77e-04 0.36300 0.299000 0.207000 1.12e-04 7.47e-03
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 5.67e-05 2.84e-04 0.60800 0.391000 0.466000 2.44e-03 3.11e-04
Muscle contraction 137 5.78e-05 2.88e-04 0.22100 0.026900 0.219000 5.87e-01 9.98e-06
Regulation of TP53 Degradation 28 6.26e-05 3.09e-04 0.49900 0.175000 0.467000 1.10e-01 1.87e-05
Regulation of TP53 Expression and Degradation 28 6.26e-05 3.09e-04 0.49900 0.175000 0.467000 1.10e-01 1.87e-05
Signaling by SCF-KIT 34 6.49e-05 3.20e-04 0.44800 0.431000 0.122000 1.39e-05 2.20e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 36 6.55e-05 3.21e-04 0.45100 0.337000 0.299000 4.65e-04 1.91e-03
Disorders of transmembrane transporters 119 6.74e-05 3.29e-04 0.21700 -0.132000 0.172000 1.27e-02 1.25e-03
Regulation of RAS by GAPs 58 7.51e-05 3.65e-04 0.30900 -0.172000 0.256000 2.34e-02 7.39e-04
Innate Immune System 647 7.59e-05 3.67e-04 0.10800 0.069000 0.083000 3.02e-03 3.61e-04
TNFR2 non-canonical NF-kB pathway 62 7.91e-05 3.81e-04 0.29700 -0.177000 0.239000 1.62e-02 1.14e-03
M Phase 251 8.01e-05 3.85e-04 0.15700 -0.008360 0.157000 8.20e-01 2.00e-05
SUMO E3 ligases SUMOylate target proteins 143 8.04e-05 3.85e-04 0.22500 0.157000 0.161000 1.19e-03 9.40e-04
HATs acetylate histones 74 8.32e-05 3.96e-04 0.30500 0.128000 0.277000 5.74e-02 3.79e-05
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 22 9.06e-05 4.30e-04 0.56500 0.331000 0.458000 7.29e-03 2.03e-04
Signaling by Hippo 19 9.49e-05 4.47e-04 0.60700 0.482000 0.368000 2.73e-04 5.52e-03
Collagen biosynthesis and modifying enzymes 44 9.49e-05 4.47e-04 0.37700 -0.042400 -0.375000 6.27e-01 1.69e-05
RHO GTPases Activate Formins 84 1.03e-04 4.84e-04 0.28800 0.169000 0.233000 7.57e-03 2.28e-04
Constitutive Signaling by AKT1 E17K in Cancer 23 1.05e-04 4.90e-04 0.54900 0.418000 0.357000 5.26e-04 3.05e-03
RHO GTPases activate PKNs 34 1.06e-04 4.95e-04 0.45200 0.324000 0.315000 1.08e-03 1.46e-03
Diseases associated with O-glycosylation of proteins 41 1.07e-04 4.96e-04 0.39000 -0.056600 -0.386000 5.31e-01 1.90e-05
Interleukin-17 signaling 63 1.09e-04 5.06e-04 0.33000 0.178000 0.278000 1.49e-02 1.39e-04
MAPK targets/ Nuclear events mediated by MAP kinases 29 1.12e-04 5.15e-04 0.48800 0.321000 0.368000 2.81e-03 6.14e-04
Asparagine N-linked glycosylation 235 1.17e-04 5.37e-04 0.16500 0.035600 0.161000 3.49e-01 2.23e-05
Signaling by NOTCH 155 1.20e-04 5.47e-04 0.20800 0.087500 0.188000 6.06e-02 5.47e-05
Signaling by EGFR 41 1.23e-04 5.60e-04 0.40800 0.267000 0.309000 3.16e-03 6.15e-04
Downregulation of TGF-beta receptor signaling 25 1.25e-04 5.68e-04 0.52100 0.327000 0.407000 4.73e-03 4.34e-04
Signaling by NTRKs 83 1.26e-04 5.68e-04 0.28700 0.189000 0.217000 3.02e-03 6.58e-04
Downstream TCR signaling 76 1.27e-04 5.72e-04 0.26800 -0.079800 0.256000 2.30e-01 1.15e-04
Attenuation phase 20 1.40e-04 6.25e-04 0.58000 0.427000 0.393000 9.45e-04 2.36e-03
Intra-Golgi and retrograde Golgi-to-ER traffic 144 1.51e-04 6.76e-04 0.20900 0.058200 0.201000 2.29e-01 3.39e-05
GPCR ligand binding 107 1.80e-04 8.00e-04 0.22700 0.027400 -0.225000 6.25e-01 5.89e-05
Transcriptional Regulation by MECP2 44 1.87e-04 8.29e-04 0.38300 0.218000 0.315000 1.23e-02 3.02e-04
Formation of the beta-catenin:TCF transactivating complex 30 2.22e-04 9.78e-04 0.46100 0.295000 0.354000 5.20e-03 7.83e-04
Beta-catenin independent WNT signaling 114 2.23e-04 9.81e-04 0.21400 -0.050000 0.208000 3.58e-01 1.27e-04
UCH proteinases 75 2.28e-04 1.00e-03 0.25400 -0.164000 0.195000 1.42e-02 3.60e-03
ER-Phagosome pathway 68 2.32e-04 1.01e-03 0.26700 -0.158000 0.216000 2.46e-02 2.10e-03
HSF1-dependent transactivation 29 2.52e-04 1.09e-03 0.46500 0.285000 0.367000 7.96e-03 6.20e-04
Myogenesis 25 2.54e-04 1.10e-03 0.49100 0.195000 0.451000 9.15e-02 9.66e-05
DARPP-32 events 21 2.58e-04 1.11e-03 0.52900 0.163000 0.504000 1.96e-01 6.46e-05
trans-Golgi Network Vesicle Budding 60 2.65e-04 1.14e-03 0.32100 0.180000 0.267000 1.62e-02 3.59e-04
Nuclear Receptor transcription pathway 41 2.66e-04 1.14e-03 0.38800 0.205000 0.329000 2.35e-02 2.67e-04
Platelet activation, signaling and aggregation 169 2.67e-04 1.14e-03 0.18900 0.174000 0.074900 1.00e-04 9.39e-02
Dectin-2 family 10 2.71e-04 1.15e-03 0.74100 -0.054000 -0.739000 7.67e-01 5.24e-05
COPI-mediated anterograde transport 71 2.84e-04 1.21e-03 0.28300 0.060000 0.277000 3.83e-01 5.61e-05
COPI-independent Golgi-to-ER retrograde traffic 28 3.06e-04 1.30e-03 0.46800 0.298000 0.361000 6.34e-03 9.62e-04
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 42 3.26e-04 1.38e-03 0.38100 0.284000 0.254000 1.44e-03 4.46e-03
VEGFA-VEGFR2 Pathway 78 3.55e-04 1.49e-03 0.27900 0.205000 0.189000 1.78e-03 3.98e-03
Mitotic G2-G2/M phases 149 3.63e-04 1.52e-03 0.17800 -0.083500 0.157000 7.92e-02 9.79e-04
Apoptotic cleavage of cellular proteins 28 3.68e-04 1.53e-03 0.46300 0.306000 0.347000 5.06e-03 1.48e-03
Resolution of Sister Chromatid Cohesion 69 3.71e-04 1.54e-03 0.29300 0.158000 0.247000 2.33e-02 3.92e-04
G2/M Transition 148 3.80e-04 1.57e-03 0.17700 -0.088000 0.154000 6.52e-02 1.25e-03
RORA activates gene expression 17 3.82e-04 1.58e-03 0.59300 0.424000 0.414000 2.48e-03 3.10e-03
Cellular response to heat stress 87 3.85e-04 1.58e-03 0.25700 0.099100 0.237000 1.11e-01 1.36e-04
O-glycosylation of TSR domain-containing proteins 26 4.24e-04 1.74e-03 0.44500 -0.021900 -0.445000 8.47e-01 8.66e-05
HDMs demethylate histones 21 4.27e-04 1.74e-03 0.53000 0.380000 0.369000 2.58e-03 3.43e-03
G2/M Checkpoints 103 4.28e-04 1.74e-03 0.21000 -0.113000 0.177000 4.79e-02 1.93e-03
Intra-Golgi traffic 35 4.36e-04 1.77e-03 0.39800 0.131000 0.376000 1.79e-01 1.19e-04
Interleukin-1 signaling 83 4.38e-04 1.77e-03 0.24100 -0.053400 0.235000 4.01e-01 2.24e-04
Peptide ligand-binding receptors 39 4.40e-04 1.77e-03 0.33900 0.194000 -0.278000 3.63e-02 2.63e-03
Signaling by VEGF 85 5.17e-04 2.08e-03 0.25900 0.214000 0.146000 6.42e-04 2.04e-02
Formation of Incision Complex in GG-NER 40 5.33e-04 2.13e-03 0.33300 -0.155000 0.295000 9.01e-02 1.26e-03
Signaling by MET 56 5.56e-04 2.22e-03 0.31900 0.209000 0.241000 6.79e-03 1.85e-03
Global Genome Nucleotide Excision Repair (GG-NER) 76 5.74e-04 2.28e-03 0.23800 -0.177000 0.160000 7.70e-03 1.63e-02
Regulation of localization of FOXO transcription factors 11 6.11e-04 2.42e-03 0.71400 0.486000 0.523000 5.23e-03 2.66e-03
Activation of BH3-only proteins 24 6.61e-04 2.61e-03 0.48100 0.326000 0.354000 5.77e-03 2.67e-03
Regulation of PTEN gene transcription 56 7.04e-04 2.77e-03 0.31200 0.169000 0.262000 2.85e-02 7.01e-04
Disassembly of the destruction complex and recruitment of AXIN to the membrane 25 7.69e-04 3.02e-03 0.45800 0.194000 0.415000 9.36e-02 3.26e-04
Negative regulation of MAPK pathway 39 7.73e-04 3.02e-03 0.35600 0.063600 0.350000 4.92e-01 1.56e-04
Oxidative Stress Induced Senescence 64 7.81e-04 3.05e-03 0.28800 0.139000 0.253000 5.48e-02 4.79e-04
TICAM1, RIP1-mediated IKK complex recruitment 18 8.14e-04 3.16e-03 0.52400 0.115000 0.512000 3.97e-01 1.72e-04
Elastic fibre formation 33 8.87e-04 3.44e-03 0.35000 0.242000 -0.254000 1.63e-02 1.17e-02
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 31 9.12e-04 3.52e-03 0.41400 0.284000 0.301000 6.15e-03 3.72e-03
Defective B3GALTL causes Peters-plus syndrome (PpS) 25 9.68e-04 3.73e-03 0.42600 0.005530 -0.426000 9.62e-01 2.30e-04
Regulation of TP53 Activity 130 9.99e-04 3.83e-03 0.20200 0.142000 0.143000 5.19e-03 4.94e-03
Cell-Cell communication 74 1.01e-03 3.85e-03 0.25600 0.248000 0.063100 2.24e-04 3.48e-01
IGF1R signaling cascade 30 1.11e-03 4.23e-03 0.41500 0.284000 0.303000 7.14e-03 4.11e-03
Signaling by FGFR2 52 1.12e-03 4.26e-03 0.31200 0.153000 0.272000 5.61e-02 7.12e-04
Mitotic Spindle Checkpoint 74 1.14e-03 4.34e-03 0.25600 0.081400 0.243000 2.27e-01 3.07e-04
TCR signaling 90 1.16e-03 4.39e-03 0.21700 -0.041300 0.213000 4.99e-01 4.90e-04
Signaling by FGFR1 in disease 31 1.18e-03 4.43e-03 0.40600 0.305000 0.269000 3.33e-03 9.60e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling 29 1.18e-03 4.45e-03 0.40900 0.383000 0.146000 3.64e-04 1.74e-01
Misspliced GSK3beta mutants stabilize beta-catenin 15 1.28e-03 4.69e-03 0.57700 0.319000 0.481000 3.25e-02 1.26e-03
S33 mutants of beta-catenin aren’t phosphorylated 15 1.28e-03 4.69e-03 0.57700 0.319000 0.481000 3.25e-02 1.26e-03
S37 mutants of beta-catenin aren’t phosphorylated 15 1.28e-03 4.69e-03 0.57700 0.319000 0.481000 3.25e-02 1.26e-03
S45 mutants of beta-catenin aren’t phosphorylated 15 1.28e-03 4.69e-03 0.57700 0.319000 0.481000 3.25e-02 1.26e-03
T41 mutants of beta-catenin aren’t phosphorylated 15 1.28e-03 4.69e-03 0.57700 0.319000 0.481000 3.25e-02 1.26e-03
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 1.28e-03 4.69e-03 0.57700 0.319000 0.481000 3.25e-02 1.26e-03
Phase II - Conjugation of compounds 50 1.28e-03 4.69e-03 0.27700 -0.188000 0.204000 2.19e-02 1.25e-02
Interleukin-6 signaling 11 1.32e-03 4.84e-03 0.66300 0.605000 0.270000 5.07e-04 1.21e-01
IRS-related events triggered by IGF1R 29 1.35e-03 4.93e-03 0.41600 0.274000 0.313000 1.07e-02 3.57e-03
Rho GTPase cycle 113 1.40e-03 5.10e-03 0.19300 0.191000 -0.022600 4.48e-04 6.79e-01
Death Receptor Signalling 114 1.41e-03 5.10e-03 0.20600 0.186000 0.090100 6.28e-04 9.71e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 39 1.42e-03 5.15e-03 0.32400 0.058200 -0.319000 5.30e-01 5.71e-04
Beta-catenin phosphorylation cascade 16 1.45e-03 5.23e-03 0.55300 0.300000 0.464000 3.76e-02 1.30e-03
Signaling by FGFR1 38 1.48e-03 5.30e-03 0.36100 0.259000 0.252000 5.83e-03 7.20e-03
RMTs methylate histone arginines 29 1.48e-03 5.30e-03 0.38800 0.029000 0.387000 7.87e-01 3.15e-04
Insulin receptor signalling cascade 31 1.52e-03 5.42e-03 0.39800 0.253000 0.308000 1.48e-02 3.05e-03
Gluconeogenesis 22 1.55e-03 5.51e-03 0.41900 -0.385000 0.165000 1.80e-03 1.80e-01
Nuclear Events (kinase and transcription factor activation) 23 1.57e-03 5.58e-03 0.45800 0.237000 0.391000 4.89e-02 1.16e-03
MECP2 regulates neuronal receptors and channels 11 1.64e-03 5.81e-03 0.65300 0.593000 0.273000 6.64e-04 1.16e-01
Meiosis 42 1.66e-03 5.85e-03 0.33200 0.118000 0.310000 1.86e-01 5.09e-04
Oncogenic MAPK signaling 58 1.66e-03 5.86e-03 0.29000 0.201000 0.209000 8.10e-03 6.02e-03
RAF activation 30 1.76e-03 6.17e-03 0.38400 0.088000 0.374000 4.04e-01 3.93e-04
Semaphorin interactions 55 1.83e-03 6.41e-03 0.27100 0.269000 -0.027800 5.61e-04 7.22e-01
IRS-mediated signalling 26 1.87e-03 6.51e-03 0.42800 0.274000 0.329000 1.58e-02 3.69e-03
Activation of BAD and translocation to mitochondria 13 1.87e-03 6.53e-03 0.59900 0.296000 0.520000 6.44e-02 1.16e-03
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 34 1.95e-03 6.77e-03 0.36900 0.184000 0.321000 6.38e-02 1.22e-03
Transcriptional regulation of granulopoiesis 26 1.97e-03 6.82e-03 0.42400 0.353000 0.235000 1.84e-03 3.82e-02
Signaling by FGFR 61 2.00e-03 6.90e-03 0.27700 0.159000 0.227000 3.24e-02 2.15e-03
SUMOylation of intracellular receptors 26 2.00e-03 6.90e-03 0.42600 0.292000 0.310000 9.97e-03 6.21e-03
Glycogen metabolism 24 2.06e-03 7.07e-03 0.41400 0.020700 0.413000 8.61e-01 4.59e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF) 51 2.07e-03 7.07e-03 0.30400 0.223000 0.206000 5.93e-03 1.09e-02
Cyclin D associated events in G1 38 2.24e-03 7.62e-03 0.34100 0.126000 0.317000 1.79e-01 7.30e-04
G1 Phase 38 2.24e-03 7.62e-03 0.34100 0.126000 0.317000 1.79e-01 7.30e-04
G alpha (12/13) signalling events 56 2.30e-03 7.79e-03 0.26200 0.260000 -0.033100 7.57e-04 6.69e-01
Mitochondrial calcium ion transport 21 2.31e-03 7.80e-03 0.40900 -0.322000 0.252000 1.06e-02 4.61e-02
Glycogen synthesis 13 2.36e-03 7.98e-03 0.55000 -0.009700 0.550000 9.52e-01 5.91e-04
Regulation of MECP2 expression and activity 28 2.42e-03 8.13e-03 0.39900 0.189000 0.351000 8.30e-02 1.29e-03
Signaling by NOTCH3 40 2.46e-03 8.24e-03 0.33800 0.232000 0.246000 1.11e-02 7.21e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 29 2.48e-03 8.29e-03 0.36200 -0.048100 0.359000 6.54e-01 8.36e-04
BMAL1:CLOCK,NPAS2 activates circadian gene expression 23 2.53e-03 8.44e-03 0.44400 0.339000 0.287000 4.95e-03 1.72e-02
COPII-mediated vesicle transport 57 2.54e-03 8.45e-03 0.28200 0.211000 0.188000 5.92e-03 1.43e-02
Meiotic synapsis 26 2.60e-03 8.63e-03 0.40800 0.162000 0.375000 1.52e-01 9.46e-04
mTOR signalling 37 2.65e-03 8.78e-03 0.32700 0.019700 0.326000 8.36e-01 5.95e-04
FOXO-mediated transcription of cell death genes 13 2.72e-03 8.98e-03 0.58500 0.340000 0.476000 3.39e-02 2.97e-03
HSF1 activation 24 2.73e-03 8.98e-03 0.43000 0.245000 0.353000 3.77e-02 2.73e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 60 2.78e-03 9.11e-03 0.27100 0.140000 0.232000 6.03e-02 1.93e-03
Amplification of signal from the kinetochores 60 2.78e-03 9.11e-03 0.27100 0.140000 0.232000 6.03e-02 1.93e-03
mRNA Splicing - Minor Pathway 39 2.79e-03 9.12e-03 0.29700 -0.149000 0.257000 1.08e-01 5.44e-03
RET signaling 27 2.96e-03 9.65e-03 0.39600 0.366000 0.151000 1.01e-03 1.75e-01
Deactivation of the beta-catenin transactivating complex 36 3.01e-03 9.78e-03 0.34900 0.209000 0.279000 3.00e-02 3.73e-03
Signaling by NODAL 11 3.03e-03 9.80e-03 0.63100 0.495000 0.392000 4.51e-03 2.43e-02
Autophagy 94 3.07e-03 9.90e-03 0.20600 0.036000 0.203000 5.47e-01 6.75e-04
MET activates RAP1 and RAC1 10 3.07e-03 9.90e-03 0.66100 0.401000 0.525000 2.80e-02 4.05e-03
Striated Muscle Contraction 30 3.11e-03 1.00e-02 0.34300 -0.092300 0.330000 3.82e-01 1.74e-03
Protein ubiquitination 59 3.13e-03 1.00e-02 0.26700 0.103000 0.246000 1.73e-01 1.08e-03
AMER1 mutants destabilize the destruction complex 14 3.18e-03 1.00e-02 0.55500 0.303000 0.465000 4.96e-02 2.62e-03
APC truncation mutants have impaired AXIN binding 14 3.18e-03 1.00e-02 0.55500 0.303000 0.465000 4.96e-02 2.62e-03
AXIN missense mutants destabilize the destruction complex 14 3.18e-03 1.00e-02 0.55500 0.303000 0.465000 4.96e-02 2.62e-03
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 3.18e-03 1.00e-02 0.55500 0.303000 0.465000 4.96e-02 2.62e-03
Truncations of AMER1 destabilize the destruction complex 14 3.18e-03 1.00e-02 0.55500 0.303000 0.465000 4.96e-02 2.62e-03
truncated APC mutants destabilize the destruction complex 14 3.18e-03 1.00e-02 0.55500 0.303000 0.465000 4.96e-02 2.62e-03
Nucleotide Excision Repair 97 3.33e-03 1.04e-02 0.18500 -0.133000 0.128000 2.36e-02 2.99e-02
tRNA processing 86 3.33e-03 1.04e-02 0.19800 -0.178000 0.087900 4.41e-03 1.59e-01
Nephrin family interactions 17 3.34e-03 1.04e-02 0.48500 0.469000 0.123000 8.06e-04 3.81e-01
Signaling by FGFR3 29 3.38e-03 1.05e-02 0.38500 0.242000 0.300000 2.39e-02 5.23e-03
Regulation of PTEN mRNA translation 12 3.38e-03 1.05e-02 0.60000 0.405000 0.442000 1.51e-02 8.05e-03
Phosphorylation of CD3 and TCR zeta chains 12 3.50e-03 1.08e-02 0.52600 0.254000 -0.460000 1.28e-01 5.78e-03
Signaling by BRAF and RAF fusions 54 3.50e-03 1.08e-02 0.28100 0.168000 0.226000 3.31e-02 4.11e-03
Hedgehog ‘on’ state 71 3.70e-03 1.14e-02 0.21400 -0.152000 0.150000 2.72e-02 2.88e-02
Constitutive Signaling by EGFRvIII 15 3.87e-03 1.19e-02 0.52800 0.428000 0.310000 4.15e-03 3.77e-02
Signaling by EGFRvIII in Cancer 15 3.87e-03 1.19e-02 0.52800 0.428000 0.310000 4.15e-03 3.77e-02
NRAGE signals death through JNK 44 3.99e-03 1.22e-02 0.28800 0.288000 0.007490 9.57e-04 9.32e-01
Glycogen storage diseases 13 4.01e-03 1.23e-02 0.50100 -0.219000 0.451000 1.72e-01 4.92e-03
Antigen processing-Cross presentation 77 4.05e-03 1.23e-02 0.20400 -0.111000 0.171000 9.13e-02 9.38e-03
RNA Polymerase II Transcription Termination 54 4.13e-03 1.25e-02 0.24300 -0.151000 0.190000 5.44e-02 1.61e-02
Retrograde transport at the Trans-Golgi-Network 44 4.14e-03 1.26e-02 0.29200 0.040900 0.289000 6.39e-01 9.25e-04
Diseases of glycosylation 97 4.23e-03 1.28e-02 0.19500 -0.015700 -0.194000 7.90e-01 9.64e-04
Post-translational modification: synthesis of GPI-anchored proteins 42 4.36e-03 1.31e-02 0.31300 -0.199000 -0.242000 2.54e-02 6.77e-03
IKK complex recruitment mediated by RIP1 20 4.39e-03 1.32e-02 0.44400 0.176000 0.408000 1.73e-01 1.58e-03
Activation of gene expression by SREBF (SREBP) 39 4.42e-03 1.33e-02 0.32500 0.218000 0.241000 1.88e-02 9.10e-03
Activation of GABAB receptors 23 4.70e-03 1.40e-02 0.36700 0.215000 -0.298000 7.40e-02 1.35e-02
GABA B receptor activation 23 4.70e-03 1.40e-02 0.36700 0.215000 -0.298000 7.40e-02 1.35e-02
Metabolism of lipids 509 4.80e-03 1.43e-02 0.08780 0.025000 0.084200 3.39e-01 1.25e-03
Cell-extracellular matrix interactions 15 4.89e-03 1.45e-02 0.51900 0.382000 0.351000 1.04e-02 1.87e-02
Smooth Muscle Contraction 35 4.94e-03 1.47e-02 0.32000 0.036100 0.318000 7.12e-01 1.12e-03
AKT phosphorylates targets in the nucleus 10 5.03e-03 1.49e-02 0.63300 0.478000 0.416000 8.92e-03 2.28e-02
Interleukin-1 family signaling 103 5.13e-03 1.51e-02 0.18400 -0.000140 0.184000 9.98e-01 1.30e-03
Tie2 Signaling 14 5.14e-03 1.51e-02 0.52600 0.470000 0.238000 2.34e-03 1.24e-01
Signaling by FGFR4 31 5.16e-03 1.52e-02 0.35900 0.243000 0.265000 1.95e-02 1.07e-02
Axon guidance 382 5.25e-03 1.54e-02 0.09640 0.001110 0.096400 9.70e-01 1.31e-03
DNA Repair 236 5.29e-03 1.55e-02 0.11500 -0.058000 0.099200 1.26e-01 8.89e-03
Signaling by EGFR in Cancer 21 5.38e-03 1.57e-02 0.43500 0.308000 0.307000 1.46e-02 1.50e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 48 5.43e-03 1.58e-02 0.26500 -0.014600 0.265000 8.61e-01 1.52e-03
Negative regulation of the PI3K/AKT network 73 5.50e-03 1.59e-02 0.23300 0.175000 0.154000 9.78e-03 2.33e-02
Signaling by NOTCH2 27 5.50e-03 1.59e-02 0.38200 0.302000 0.233000 6.54e-03 3.64e-02
Senescence-Associated Secretory Phenotype (SASP) 44 5.75e-03 1.66e-02 0.28700 0.068000 0.278000 4.35e-01 1.40e-03
PI3K Cascade 22 5.77e-03 1.66e-02 0.41900 0.224000 0.354000 6.87e-02 4.10e-03
Downstream signaling of activated FGFR2 17 5.98e-03 1.72e-02 0.47600 0.389000 0.274000 5.48e-03 5.04e-02
L1CAM interactions 69 6.22e-03 1.78e-02 0.23400 0.206000 0.110000 3.05e-03 1.16e-01
Platelet Aggregation (Plug Formation) 23 6.29e-03 1.80e-02 0.38100 0.381000 0.004610 1.58e-03 9.69e-01
Hedgehog ‘off’ state 88 6.33e-03 1.80e-02 0.18200 -0.131000 0.127000 3.40e-02 3.95e-02
APC-Cdc20 mediated degradation of Nek2A 20 6.37e-03 1.81e-02 0.38200 -0.235000 0.302000 6.92e-02 1.96e-02
Epigenetic regulation of gene expression 80 6.46e-03 1.83e-02 0.21900 0.138000 0.170000 3.32e-02 8.63e-03
Amino acid transport across the plasma membrane 21 6.63e-03 1.88e-02 0.37700 -0.153000 0.344000 2.24e-01 6.35e-03
Transport of small molecules 447 6.64e-03 1.88e-02 0.08190 -0.050400 0.064500 6.97e-02 2.03e-02
Glucose metabolism 72 6.75e-03 1.90e-02 0.20300 -0.087400 0.183000 2.00e-01 7.22e-03
Cell surface interactions at the vascular wall 76 7.17e-03 2.02e-02 0.20300 0.202000 -0.024300 2.36e-03 7.15e-01
Citric acid cycle (TCA cycle) 21 7.19e-03 2.02e-02 0.39600 0.028400 0.395000 8.22e-01 1.72e-03
Uptake and actions of bacterial toxins 22 7.33e-03 2.05e-02 0.40700 0.357000 0.196000 3.79e-03 1.12e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 14 7.35e-03 2.05e-02 0.50200 0.172000 0.472000 2.67e-01 2.24e-03
CD28 dependent PI3K/Akt signaling 14 7.41e-03 2.06e-02 0.51000 0.255000 0.442000 9.86e-02 4.20e-03
tRNA modification in the nucleus and cytosol 30 7.65e-03 2.13e-02 0.31400 -0.298000 0.098400 4.76e-03 3.51e-01
NOD1/2 Signaling Pathway 29 7.69e-03 2.13e-02 0.35700 0.258000 0.247000 1.63e-02 2.13e-02
Downstream signaling of activated FGFR1 21 7.77e-03 2.15e-02 0.41600 0.352000 0.222000 5.27e-03 7.83e-02
EGFR downregulation 25 7.83e-03 2.16e-02 0.38100 0.205000 0.321000 7.54e-02 5.48e-03
Deadenylation-dependent mRNA decay 50 7.88e-03 2.17e-02 0.26900 0.143000 0.228000 7.97e-02 5.29e-03
TNFR1-induced NFkappaB signaling pathway 24 7.95e-03 2.18e-02 0.38200 0.144000 0.354000 2.24e-01 2.68e-03
Regulation of RUNX1 Expression and Activity 17 8.04e-03 2.21e-02 0.44900 0.429000 0.133000 2.21e-03 3.43e-01
Integrin alphaIIb beta3 signaling 20 8.11e-03 2.21e-02 0.40700 0.400000 0.072600 1.94e-03 5.74e-01
Integrin signaling 20 8.11e-03 2.21e-02 0.40700 0.400000 0.072600 1.94e-03 5.74e-01
CLEC7A (Dectin-1) induces NFAT activation 11 8.18e-03 2.23e-02 0.53800 0.023900 0.538000 8.91e-01 2.02e-03
Synthesis of PIPs at the early endosome membrane 16 8.33e-03 2.26e-02 0.47700 0.333000 0.341000 2.12e-02 1.82e-02
Degradation of the extracellular matrix 58 8.35e-03 2.26e-02 0.21900 0.174000 -0.132000 2.17e-02 8.24e-02
GPCR downstream signalling 296 8.36e-03 2.26e-02 0.09920 0.091300 -0.038800 7.16e-03 2.52e-01
Pre-NOTCH Processing in Golgi 16 8.47e-03 2.29e-02 0.41400 0.299000 -0.287000 3.85e-02 4.70e-02
G alpha (q) signalling events 79 8.88e-03 2.39e-02 0.20500 0.199000 0.050600 2.27e-03 4.37e-01
Interleukin-12 family signaling 35 8.91e-03 2.39e-02 0.31000 0.093100 0.296000 3.41e-01 2.49e-03
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 25 8.95e-03 2.40e-02 0.37800 0.240000 0.292000 3.77e-02 1.16e-02
ERK/MAPK targets 20 9.09e-03 2.43e-02 0.41900 0.220000 0.356000 8.84e-02 5.80e-03
Downstream signaling of activated FGFR3 15 9.23e-03 2.46e-02 0.48400 0.404000 0.265000 6.69e-03 7.52e-02
Energy dependent regulation of mTOR by LKB1-AMPK 26 9.25e-03 2.46e-02 0.34400 0.002430 0.344000 9.83e-01 2.41e-03
Metabolism of nucleotides 77 9.26e-03 2.46e-02 0.19100 -0.177000 0.072600 7.44e-03 2.71e-01
Signaling by GPCR 321 9.27e-03 2.46e-02 0.09350 0.081300 -0.046200 1.27e-02 1.57e-01
Pre-NOTCH Expression and Processing 48 9.38e-03 2.48e-02 0.25700 0.255000 0.029100 2.25e-03 7.27e-01
Generation of second messenger molecules 18 9.39e-03 2.48e-02 0.38800 0.318000 -0.222000 1.96e-02 1.03e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 9.64e-03 2.54e-02 0.33500 0.178000 0.283000 8.57e-02 6.37e-03
Adenylate cyclase inhibitory pathway 12 9.69e-03 2.55e-02 0.47400 0.402000 -0.252000 1.58e-02 1.31e-01
Loss of function of MECP2 in Rett syndrome 11 9.83e-03 2.57e-02 0.53300 0.065400 0.529000 7.07e-01 2.36e-03
Pervasive developmental disorders 11 9.83e-03 2.57e-02 0.53300 0.065400 0.529000 7.07e-01 2.36e-03
DNA Damage Recognition in GG-NER 35 9.95e-03 2.60e-02 0.27600 -0.207000 0.182000 3.42e-02 6.23e-02
Detoxification of Reactive Oxygen Species 23 1.00e-02 2.61e-02 0.34000 -0.251000 0.229000 3.76e-02 5.72e-02
MET promotes cell motility 24 1.03e-02 2.69e-02 0.38000 0.296000 0.238000 1.22e-02 4.36e-02
Ion homeostasis 42 1.06e-02 2.76e-02 0.27400 0.055400 0.268000 5.35e-01 2.63e-03
Regulation of signaling by CBL 14 1.11e-02 2.86e-02 0.47900 0.455000 0.149000 3.21e-03 3.34e-01
EPH-Ephrin signaling 68 1.11e-02 2.86e-02 0.22400 0.177000 0.138000 1.18e-02 4.94e-02
activated TAK1 mediates p38 MAPK activation 18 1.13e-02 2.91e-02 0.43300 0.247000 0.356000 7.00e-02 9.03e-03
Factors involved in megakaryocyte development and platelet production 84 1.16e-02 2.97e-02 0.18900 0.188000 0.016400 2.86e-03 7.95e-01
VEGFR2 mediated vascular permeability 21 1.16e-02 2.97e-02 0.39600 0.184000 0.351000 1.44e-01 5.43e-03
Non-integrin membrane-ECM interactions 33 1.22e-02 3.11e-02 0.28700 0.278000 -0.070900 5.77e-03 4.81e-01
Binding and Uptake of Ligands by Scavenger Receptors 26 1.22e-02 3.11e-02 0.31500 0.166000 -0.267000 1.43e-01 1.84e-02
RUNX2 regulates bone development 26 1.22e-02 3.12e-02 0.35800 0.224000 0.279000 4.83e-02 1.37e-02
Signaling by FGFR3 in disease 12 1.23e-02 3.12e-02 0.52700 0.394000 0.350000 1.81e-02 3.59e-02
Signaling by FGFR3 point mutants in cancer 12 1.23e-02 3.12e-02 0.52700 0.394000 0.350000 1.81e-02 3.59e-02
Downstream signaling of activated FGFR4 17 1.24e-02 3.12e-02 0.43700 0.386000 0.206000 5.93e-03 1.41e-01
Peroxisomal protein import 50 1.24e-02 3.12e-02 0.22600 -0.139000 0.177000 8.86e-02 3.01e-02
Fcgamma receptor (FCGR) dependent phagocytosis 69 1.24e-02 3.13e-02 0.21700 0.194000 0.096500 5.34e-03 1.66e-01
RNA polymerase II transcribes snRNA genes 64 1.27e-02 3.19e-02 0.22600 0.122000 0.190000 9.06e-02 8.46e-03
Signaling by ERBB2 41 1.27e-02 3.19e-02 0.28300 0.162000 0.232000 7.27e-02 1.01e-02
CD28 co-stimulation 22 1.27e-02 3.19e-02 0.38600 0.219000 0.318000 7.57e-02 9.81e-03
Signaling by Erythropoietin 21 1.28e-02 3.20e-02 0.38400 0.366000 0.119000 3.72e-03 3.47e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 1.28e-02 3.20e-02 0.54800 0.364000 0.410000 3.67e-02 1.86e-02
PD-1 signaling 13 1.29e-02 3.21e-02 0.44100 0.240000 -0.370000 1.34e-01 2.08e-02
Processing of SMDT1 14 1.29e-02 3.22e-02 0.42600 -0.364000 0.221000 1.85e-02 1.52e-01
Signalling to ERKs 30 1.37e-02 3.41e-02 0.33000 0.235000 0.231000 2.60e-02 2.85e-02
Import of palmitoyl-CoA into the mitochondrial matrix 11 1.39e-02 3.43e-02 0.53900 0.458000 0.284000 8.57e-03 1.03e-01
p75 NTR receptor-mediated signalling 73 1.41e-02 3.49e-02 0.20400 0.195000 0.060100 4.02e-03 3.75e-01
Assembly of active LPL and LIPC lipase complexes 10 1.44e-02 3.55e-02 0.49600 0.407000 -0.283000 2.58e-02 1.21e-01
Activated NOTCH1 Transmits Signal to the Nucleus 26 1.45e-02 3.57e-02 0.33400 0.330000 0.052600 3.62e-03 6.43e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 1.46e-02 3.58e-02 0.47200 0.386000 -0.271000 2.66e-02 1.19e-01
Keratan sulfate biosynthesis 18 1.46e-02 3.58e-02 0.38600 0.384000 -0.041600 4.78e-03 7.60e-01
Nucleotide salvage 18 1.46e-02 3.58e-02 0.37000 -0.312000 0.199000 2.20e-02 1.45e-01
Deadenylation of mRNA 24 1.48e-02 3.62e-02 0.36500 0.240000 0.274000 4.15e-02 2.00e-02
Transcriptional regulation of pluripotent stem cells 11 1.49e-02 3.62e-02 0.53400 0.273000 0.459000 1.17e-01 8.44e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 62 1.50e-02 3.66e-02 0.19900 -0.110000 0.165000 1.33e-01 2.47e-02
Pre-NOTCH Transcription and Translation 34 1.51e-02 3.67e-02 0.30200 0.269000 0.137000 6.69e-03 1.68e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 21 1.52e-02 3.68e-02 0.38900 0.292000 0.257000 2.07e-02 4.12e-02
Rap1 signalling 13 1.55e-02 3.74e-02 0.49300 0.316000 0.378000 4.83e-02 1.84e-02
Cell death signalling via NRAGE, NRIF and NADE 58 1.55e-02 3.74e-02 0.22800 0.213000 0.082400 5.12e-03 2.78e-01
mRNA 3’-end processing 46 1.57e-02 3.78e-02 0.22900 -0.140000 0.181000 9.98e-02 3.43e-02
Syndecan interactions 15 1.60e-02 3.83e-02 0.40800 0.385000 -0.134000 9.81e-03 3.68e-01
NCAM1 interactions 21 1.61e-02 3.86e-02 0.35500 0.028600 -0.354000 8.21e-01 5.02e-03
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 67 1.62e-02 3.89e-02 0.21600 0.166000 0.139000 1.91e-02 4.95e-02
B-WICH complex positively regulates rRNA expression 30 1.66e-02 3.96e-02 0.32200 0.234000 0.222000 2.69e-02 3.54e-02
NR1H2 and NR1H3-mediated signaling 37 1.67e-02 3.98e-02 0.28600 0.133000 0.253000 1.62e-01 7.72e-03
DNA strand elongation 28 1.67e-02 3.98e-02 0.32300 -0.307000 -0.098400 4.91e-03 3.68e-01
Purine salvage 13 1.72e-02 4.09e-02 0.42600 -0.348000 0.245000 2.98e-02 1.27e-01
RUNX3 regulates NOTCH signaling 12 1.74e-02 4.13e-02 0.50400 0.408000 0.295000 1.43e-02 7.65e-02
Diseases of carbohydrate metabolism 27 1.79e-02 4.24e-02 0.29600 -0.262000 0.138000 1.84e-02 2.16e-01
Constitutive Signaling by Aberrant PI3K in Cancer 41 1.82e-02 4.30e-02 0.27100 0.221000 0.158000 1.45e-02 8.05e-02
Ovarian tumor domain proteases 34 1.83e-02 4.30e-02 0.29500 0.137000 0.261000 1.69e-01 8.35e-03
mTORC1-mediated signalling 21 1.84e-02 4.32e-02 0.34900 -0.032500 0.347000 7.97e-01 5.90e-03
Prolonged ERK activation events 12 1.86e-02 4.36e-02 0.49200 0.200000 0.450000 2.30e-01 7.02e-03
NOTCH3 Intracellular Domain Regulates Transcription 18 1.90e-02 4.44e-02 0.40500 0.347000 0.209000 1.08e-02 1.25e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 17 1.90e-02 4.44e-02 0.41600 0.205000 0.362000 1.44e-01 9.78e-03
Neurodegenerative Diseases 17 1.90e-02 4.44e-02 0.41600 0.205000 0.362000 1.44e-01 9.78e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 19 1.92e-02 4.47e-02 0.39700 0.251000 0.308000 5.87e-02 2.03e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 19 1.92e-02 4.47e-02 0.39700 0.251000 0.308000 5.87e-02 2.03e-02
Other semaphorin interactions 15 1.99e-02 4.61e-02 0.38800 0.277000 -0.271000 6.32e-02 6.90e-02
Protein methylation 14 2.01e-02 4.66e-02 0.40600 -0.172000 0.369000 2.67e-01 1.70e-02
Glycolysis 58 2.02e-02 4.67e-02 0.20400 -0.044900 0.199000 5.54e-01 8.72e-03
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 67 2.10e-02 4.84e-02 0.18500 -0.164000 0.085000 2.05e-02 2.29e-01
Interleukin-10 signaling 15 2.14e-02 4.92e-02 0.41200 0.412000 0.016800 5.78e-03 9.10e-01
Transcriptional Regulation by E2F6 31 2.18e-02 5.01e-02 0.30300 0.260000 0.155000 1.21e-02 1.34e-01
ECM proteoglycans 34 2.31e-02 5.31e-02 0.25600 0.231000 -0.111000 1.98e-02 2.64e-01
Platelet degranulation 85 2.36e-02 5.41e-02 0.17300 0.172000 0.017200 6.24e-03 7.85e-01
E3 ubiquitin ligases ubiquitinate target proteins 40 2.39e-02 5.45e-02 0.26300 0.125000 0.231000 1.71e-01 1.13e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 31 2.39e-02 5.45e-02 0.29500 0.104000 0.276000 3.16e-01 7.91e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 2.40e-02 5.45e-02 0.49400 0.172000 0.463000 3.22e-01 7.86e-03
Regulation of HSF1-mediated heat shock response 71 2.45e-02 5.56e-02 0.19500 0.075800 0.180000 2.70e-01 8.84e-03
RNA Polymerase III Transcription Termination 18 2.46e-02 5.57e-02 0.36700 0.000865 0.367000 9.95e-01 6.98e-03
Scavenging by Class A Receptors 13 2.49e-02 5.64e-02 0.41900 0.091800 -0.409000 5.67e-01 1.07e-02
Signaling by FGFR in disease 45 2.50e-02 5.65e-02 0.24900 0.197000 0.152000 2.23e-02 7.73e-02
Rab regulation of trafficking 103 2.51e-02 5.66e-02 0.16500 0.102000 0.129000 7.29e-02 2.35e-02
Extension of Telomeres 27 2.52e-02 5.66e-02 0.30200 -0.301000 -0.021700 6.78e-03 8.45e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 2.54e-02 5.70e-02 0.40000 0.349000 0.197000 1.28e-02 1.60e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 32 2.55e-02 5.70e-02 0.27300 -0.006390 0.273000 9.50e-01 7.49e-03
Signaling by Non-Receptor Tyrosine Kinases 45 2.55e-02 5.70e-02 0.24800 0.150000 0.198000 8.20e-02 2.17e-02
Signaling by PTK6 45 2.55e-02 5.70e-02 0.24800 0.150000 0.198000 8.20e-02 2.17e-02
Synthesis of glycosylphosphatidylinositol (GPI) 15 2.56e-02 5.70e-02 0.42000 -0.390000 -0.156000 8.86e-03 2.95e-01
Organelle biogenesis and maintenance 223 2.58e-02 5.74e-02 0.10900 0.032200 0.104000 4.09e-01 7.72e-03
Chromosome Maintenance 51 2.59e-02 5.74e-02 0.21200 -0.210000 0.033000 9.57e-03 6.84e-01
Gastrin-CREB signalling pathway via PKC and MAPK 13 2.62e-02 5.80e-02 0.46000 0.361000 0.285000 2.41e-02 7.54e-02
Dual Incision in GG-NER 36 2.67e-02 5.90e-02 0.24700 -0.235000 0.077000 1.48e-02 4.24e-01
Apoptotic factor-mediated response 16 2.67e-02 5.90e-02 0.38100 -0.026700 0.380000 8.53e-01 8.44e-03
PERK regulates gene expression 25 2.68e-02 5.90e-02 0.31500 0.052800 0.311000 6.48e-01 7.16e-03
Translesion synthesis by POLI 17 2.69e-02 5.92e-02 0.35300 -0.307000 0.174000 2.83e-02 2.15e-01
Membrane binding and targetting of GAG proteins 12 2.72e-02 5.97e-02 0.42400 -0.155000 0.395000 3.53e-01 1.80e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 12 2.72e-02 5.97e-02 0.42400 -0.155000 0.395000 3.53e-01 1.80e-02
PECAM1 interactions 10 2.73e-02 5.98e-02 0.45700 0.381000 -0.253000 3.71e-02 1.66e-01
SHC1 events in EGFR signaling 10 2.78e-02 6.06e-02 0.51400 0.458000 0.232000 1.21e-02 2.05e-01
Assembly Of The HIV Virion 14 2.83e-02 6.16e-02 0.39300 -0.120000 0.374000 4.38e-01 1.53e-02
Interleukin-7 signaling 12 2.87e-02 6.24e-02 0.47300 0.373000 0.291000 2.54e-02 8.08e-02
SUMOylation of transcription cofactors 40 2.87e-02 6.24e-02 0.26000 0.172000 0.194000 5.96e-02 3.35e-02
Other interleukin signaling 16 2.88e-02 6.24e-02 0.35800 0.216000 -0.285000 1.34e-01 4.83e-02
Inflammasomes 14 2.91e-02 6.29e-02 0.43400 0.372000 0.224000 1.61e-02 1.46e-01
Regulation of KIT signaling 14 2.92e-02 6.30e-02 0.39600 0.387000 -0.082800 1.22e-02 5.92e-01
Clathrin-mediated endocytosis 110 2.93e-02 6.33e-02 0.15700 0.111000 0.110000 4.43e-02 4.60e-02
APC/C:Cdc20 mediated degradation of Cyclin B 19 2.99e-02 6.43e-02 0.32700 -0.194000 0.263000 1.43e-01 4.72e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 26 3.01e-02 6.43e-02 0.28500 -0.098600 0.267000 3.85e-01 1.84e-02
Positive epigenetic regulation of rRNA expression 45 3.01e-02 6.43e-02 0.24300 0.183000 0.160000 3.34e-02 6.39e-02
Inactivation of APC/C via direct inhibition of the APC/C complex 16 3.01e-02 6.43e-02 0.35700 -0.190000 0.302000 1.88e-01 3.63e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 16 3.01e-02 6.43e-02 0.35700 -0.190000 0.302000 1.88e-01 3.63e-02
Signaling by Hedgehog 114 3.04e-02 6.48e-02 0.13400 -0.077500 0.109000 1.54e-01 4.47e-02
Mitotic Prometaphase 133 3.05e-02 6.49e-02 0.13900 0.053100 0.128000 2.91e-01 1.09e-02
mRNA decay by 5’ to 3’ exoribonuclease 13 3.06e-02 6.51e-02 0.44400 0.198000 0.398000 2.18e-01 1.31e-02
Synaptic adhesion-like molecules 12 3.07e-02 6.51e-02 0.46600 -0.256000 -0.390000 1.25e-01 1.94e-02
PRC2 methylates histones and DNA 16 3.08e-02 6.53e-02 0.40100 0.192000 0.352000 1.83e-01 1.47e-02
Budding and maturation of HIV virion 23 3.09e-02 6.53e-02 0.30200 -0.101000 0.285000 4.04e-01 1.81e-02
Resolution of Abasic Sites (AP sites) 35 3.10e-02 6.54e-02 0.26100 -0.257000 -0.043600 8.42e-03 6.56e-01
Signaling by Insulin receptor 47 3.11e-02 6.55e-02 0.23500 0.121000 0.201000 1.51e-01 1.70e-02
Interleukin-15 signaling 11 3.12e-02 6.57e-02 0.48900 0.363000 0.328000 3.72e-02 6.00e-02
FGFR1 mutant receptor activation 24 3.15e-02 6.62e-02 0.33100 0.245000 0.222000 3.81e-02 5.94e-02
Neurexins and neuroligins 29 3.16e-02 6.63e-02 0.26300 0.150000 -0.216000 1.62e-01 4.42e-02
O-linked glycosylation 62 3.17e-02 6.63e-02 0.18600 0.035800 -0.183000 6.27e-01 1.28e-02
Molecules associated with elastic fibres 23 3.20e-02 6.69e-02 0.29900 0.278000 -0.110000 2.09e-02 3.60e-01
Oncogene Induced Senescence 30 3.24e-02 6.75e-02 0.29300 0.164000 0.243000 1.19e-01 2.14e-02
Late Phase of HIV Life Cycle 113 3.26e-02 6.78e-02 0.14200 0.004170 0.142000 9.39e-01 9.28e-03
Defective B3GAT3 causes JDSSDHD 12 3.27e-02 6.79e-02 0.40600 0.317000 -0.253000 5.75e-02 1.29e-01
Response to elevated platelet cytosolic Ca2+ 88 3.29e-02 6.83e-02 0.16500 0.161000 0.037000 9.28e-03 5.49e-01
Signaling by ERBB4 40 3.32e-02 6.88e-02 0.25100 0.114000 0.223000 2.14e-01 1.45e-02
Activation of the pre-replicative complex 21 3.34e-02 6.89e-02 0.32600 -0.326000 -0.001810 9.74e-03 9.89e-01
PI-3K cascade:FGFR2 10 3.37e-02 6.95e-02 0.50700 0.370000 0.346000 4.25e-02 5.79e-02
GABA receptor activation 25 3.37e-02 6.95e-02 0.28100 0.157000 -0.233000 1.75e-01 4.41e-02
Keratan sulfate/keratin metabolism 22 3.38e-02 6.95e-02 0.31000 0.305000 -0.055100 1.32e-02 6.55e-01
Plasma lipoprotein remodeling 15 3.39e-02 6.95e-02 0.36300 0.186000 -0.312000 2.12e-01 3.67e-02
Cytochrome c-mediated apoptotic response 13 3.41e-02 6.99e-02 0.41700 0.033600 0.416000 8.34e-01 9.45e-03
Cell junction organization 47 3.44e-02 7.04e-02 0.22900 0.209000 0.093700 1.33e-02 2.67e-01
Ephrin signaling 15 3.48e-02 7.11e-02 0.41100 0.326000 0.251000 2.90e-02 9.24e-02
The NLRP3 inflammasome 10 3.55e-02 7.24e-02 0.49900 0.424000 0.263000 2.02e-02 1.49e-01
Interleukin-12 signaling 30 3.57e-02 7.26e-02 0.27000 0.003930 0.270000 9.70e-01 1.04e-02
Formation of apoptosome 11 3.61e-02 7.31e-02 0.44400 -0.005380 0.444000 9.75e-01 1.08e-02
Regulation of the apoptosome activity 11 3.61e-02 7.31e-02 0.44400 -0.005380 0.444000 9.75e-01 1.08e-02
HIV Life Cycle 125 3.61e-02 7.31e-02 0.13100 -0.010700 0.131000 8.37e-01 1.19e-02
Formation of TC-NER Pre-Incision Complex 44 3.61e-02 7.31e-02 0.21000 -0.179000 0.111000 4.06e-02 2.05e-01
Macroautophagy 76 3.69e-02 7.45e-02 0.17000 0.006130 0.170000 9.27e-01 1.06e-02
Adrenaline,noradrenaline inhibits insulin secretion 18 3.71e-02 7.48e-02 0.34300 0.022800 -0.342000 8.67e-01 1.19e-02
Protein-protein interactions at synapses 47 3.74e-02 7.52e-02 0.20300 0.097500 -0.178000 2.48e-01 3.51e-02
Regulation of actin dynamics for phagocytic cup formation 49 3.79e-02 7.61e-02 0.22400 0.186000 0.125000 2.43e-02 1.31e-01
Fanconi Anemia Pathway 27 3.83e-02 7.68e-02 0.26400 -0.184000 0.189000 9.80e-02 8.93e-02
PKMTs methylate histone lysines 37 3.89e-02 7.79e-02 0.25800 0.192000 0.172000 4.29e-02 7.03e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.92e-02 7.83e-02 0.44200 0.019800 0.441000 9.10e-01 1.13e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 11 3.94e-02 7.86e-02 0.47200 0.366000 0.297000 3.54e-02 8.83e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 14 4.01e-02 7.98e-02 0.40200 0.105000 0.388000 4.95e-01 1.19e-02
RAF-independent MAPK1/3 activation 21 4.08e-02 8.11e-02 0.33900 0.276000 0.196000 2.83e-02 1.21e-01
Synthesis of PIPs at the plasma membrane 46 4.10e-02 8.14e-02 0.23000 0.156000 0.169000 6.81e-02 4.73e-02
Recycling pathway of L1 22 4.14e-02 8.20e-02 0.31900 0.308000 0.085000 1.24e-02 4.90e-01
Signaling by FGFR4 in disease 11 4.16e-02 8.22e-02 0.46700 0.372000 0.282000 3.26e-02 1.05e-01
Dual incision in TC-NER 55 4.17e-02 8.23e-02 0.18500 -0.165000 0.083500 3.46e-02 2.84e-01
Signaling by WNT in cancer 27 4.32e-02 8.52e-02 0.29600 0.170000 0.243000 1.27e-01 2.92e-02
Telomere Maintenance 35 4.36e-02 8.59e-02 0.23300 -0.223000 0.069400 2.26e-02 4.77e-01
Notch-HLH transcription pathway 28 4.40e-02 8.65e-02 0.28900 0.247000 0.150000 2.39e-02 1.71e-01
RNA Polymerase III Abortive And Retractive Initiation 34 4.44e-02 8.70e-02 0.24300 -0.018800 0.242000 8.49e-01 1.47e-02
RNA Polymerase III Transcription 34 4.44e-02 8.70e-02 0.24300 -0.018800 0.242000 8.49e-01 1.47e-02
Signaling by Activin 12 4.45e-02 8.71e-02 0.44400 0.315000 0.312000 5.88e-02 6.11e-02
Mitochondrial iron-sulfur cluster biogenesis 10 4.47e-02 8.72e-02 0.42700 -0.374000 0.206000 4.07e-02 2.59e-01
RIP-mediated NFkB activation via ZBP1 13 4.50e-02 8.77e-02 0.42600 0.298000 0.304000 6.31e-02 5.77e-02
Mitotic Prophase 77 4.51e-02 8.77e-02 0.17500 0.128000 0.120000 5.27e-02 6.95e-02
PI-3K cascade:FGFR1 11 4.58e-02 8.90e-02 0.46100 0.337000 0.315000 5.29e-02 7.08e-02
Translesion synthesis by REV1 16 4.63e-02 8.99e-02 0.33400 -0.278000 0.185000 5.39e-02 2.01e-01
Regulation of IFNG signaling 12 4.66e-02 9.03e-02 0.43900 0.271000 0.346000 1.05e-01 3.80e-02
Cargo recognition for clathrin-mediated endocytosis 76 4.71e-02 9.12e-02 0.17500 0.107000 0.138000 1.08e-01 3.73e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF 36 4.78e-02 9.18e-02 0.25200 0.138000 0.211000 1.52e-01 2.89e-02
Signaling by RAS mutants 36 4.78e-02 9.18e-02 0.25200 0.138000 0.211000 1.52e-01 2.89e-02
Signaling by moderate kinase activity BRAF mutants 36 4.78e-02 9.18e-02 0.25200 0.138000 0.211000 1.52e-01 2.89e-02
Signaling downstream of RAS mutants 36 4.78e-02 9.18e-02 0.25200 0.138000 0.211000 1.52e-01 2.89e-02
Metabolism of steroids 103 4.92e-02 9.44e-02 0.14800 0.075500 0.127000 1.86e-01 2.57e-02
TNF signaling 39 5.01e-02 9.59e-02 0.23400 0.073500 0.222000 4.27e-01 1.63e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 5.02e-02 9.59e-02 0.40700 0.143000 0.381000 3.72e-01 1.74e-02
Transport of Mature Transcript to Cytoplasm 71 5.03e-02 9.61e-02 0.15600 -0.111000 0.109000 1.05e-01 1.12e-01
Class B/2 (Secretin family receptors) 40 5.04e-02 9.61e-02 0.23600 -0.201000 -0.124000 2.77e-02 1.75e-01
CD209 (DC-SIGN) signaling 16 5.15e-02 9.80e-02 0.37500 0.284000 0.244000 4.91e-02 9.05e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 24 5.23e-02 9.94e-02 0.29300 0.069600 0.285000 5.55e-01 1.57e-02
Signaling by cytosolic FGFR1 fusion mutants 18 5.36e-02 1.02e-01 0.35000 0.211000 0.280000 1.22e-01 3.98e-02
Defective B4GALT7 causes EDS, progeroid type 12 5.37e-02 1.02e-01 0.37500 0.277000 -0.252000 9.65e-02 1.31e-01
Reproduction 49 5.39e-02 1.02e-01 0.20400 0.043300 0.199000 6.01e-01 1.60e-02
G alpha (i) signalling events 161 5.41e-02 1.02e-01 0.10300 0.058800 -0.084700 1.99e-01 6.44e-02
Costimulation by the CD28 family 45 5.46e-02 1.03e-01 0.22100 0.178000 0.131000 3.93e-02 1.28e-01
Negative regulation of FGFR2 signaling 21 5.47e-02 1.03e-01 0.32000 0.147000 0.284000 2.44e-01 2.44e-02
NCAM signaling for neurite out-growth 40 5.53e-02 1.04e-01 0.20400 0.140000 -0.149000 1.27e-01 1.03e-01
ATF4 activates genes in response to endoplasmic reticulum stress 21 5.54e-02 1.04e-01 0.31100 0.079500 0.301000 5.29e-01 1.70e-02
Activation of the AP-1 family of transcription factors 10 5.61e-02 1.05e-01 0.46500 0.385000 0.261000 3.52e-02 1.53e-01
Base Excision Repair 43 5.65e-02 1.06e-01 0.20500 -0.202000 0.034700 2.21e-02 6.94e-01
Erythropoietin activates RAS 12 5.66e-02 1.06e-01 0.41200 0.394000 0.120000 1.81e-02 4.70e-01
DNA Double Strand Break Response 41 5.68e-02 1.06e-01 0.23000 0.148000 0.177000 1.01e-01 5.05e-02
DAP12 interactions 22 5.86e-02 1.09e-01 0.28500 0.282000 -0.040200 2.19e-02 7.44e-01
Interconversion of nucleotide di- and triphosphates 20 5.91e-02 1.10e-01 0.28600 -0.185000 0.218000 1.53e-01 9.19e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 6.00e-02 1.11e-01 0.32300 0.282000 0.159000 2.93e-02 2.20e-01
G2/M DNA damage checkpoint 50 6.12e-02 1.13e-01 0.20600 0.126000 0.162000 1.23e-01 4.71e-02
Mucopolysaccharidoses 11 6.18e-02 1.14e-01 0.43700 -0.353000 -0.257000 4.27e-02 1.40e-01
Biological oxidations 107 6.20e-02 1.14e-01 0.12300 -0.075500 0.097100 1.78e-01 8.32e-02
Negative regulation of FGFR1 signaling 22 6.25e-02 1.15e-01 0.30500 0.141000 0.271000 2.54e-01 2.80e-02
Regulation of beta-cell development 17 6.31e-02 1.16e-01 0.35100 0.260000 0.236000 6.33e-02 9.22e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 6.32e-02 1.16e-01 0.38200 0.334000 0.186000 3.04e-02 2.29e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 6.32e-02 1.16e-01 0.38200 0.334000 0.186000 3.04e-02 2.29e-01
Interleukin-6 family signaling 19 6.43e-02 1.18e-01 0.32700 0.287000 0.157000 3.04e-02 2.36e-01
FCERI mediated MAPK activation 25 6.65e-02 1.21e-01 0.27100 0.269000 0.032700 1.99e-02 7.77e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 6.65e-02 1.21e-01 0.34000 0.315000 0.127000 2.46e-02 3.63e-01
Chaperone Mediated Autophagy 18 6.65e-02 1.21e-01 0.32500 0.082900 0.315000 5.43e-01 2.09e-02
Phase 0 - rapid depolarisation 25 6.71e-02 1.22e-01 0.25000 -0.170000 0.183000 1.42e-01 1.14e-01
Translesion synthesis by POLK 17 6.76e-02 1.23e-01 0.30200 -0.227000 0.199000 1.05e-01 1.55e-01
RAB GEFs exchange GTP for GDP on RABs 77 6.82e-02 1.24e-01 0.16300 0.125000 0.104000 5.77e-02 1.14e-01
Regulation of TNFR1 signaling 31 6.83e-02 1.24e-01 0.23900 0.008400 0.239000 9.35e-01 2.12e-02
PI3K events in ERBB2 signaling 12 6.93e-02 1.25e-01 0.37800 -0.024200 0.378000 8.85e-01 2.35e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 40 6.99e-02 1.26e-01 0.22500 0.147000 0.170000 1.07e-01 6.31e-02
AKT phosphorylates targets in the cytosol 13 7.15e-02 1.29e-01 0.39100 0.313000 0.234000 5.05e-02 1.43e-01
A tetrasaccharide linker sequence is required for GAG synthesis 15 7.19e-02 1.30e-01 0.31800 0.194000 -0.252000 1.92e-01 9.09e-02
RUNX2 regulates osteoblast differentiation 20 7.29e-02 1.31e-01 0.31500 0.194000 0.248000 1.34e-01 5.49e-02
HDACs deacetylate histones 32 7.32e-02 1.32e-01 0.24000 0.064700 0.231000 5.27e-01 2.36e-02
CRMPs in Sema3A signaling 13 7.35e-02 1.32e-01 0.34100 0.270000 -0.208000 9.25e-02 1.94e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 7.47e-02 1.34e-01 0.31000 -0.134000 0.279000 3.54e-01 5.31e-02
CTLA4 inhibitory signaling 17 7.52e-02 1.35e-01 0.33900 0.263000 0.215000 6.06e-02 1.25e-01
GAB1 signalosome 13 7.53e-02 1.35e-01 0.38900 0.284000 0.265000 7.63e-02 9.79e-02
Frs2-mediated activation 10 7.57e-02 1.35e-01 0.41800 0.048200 0.415000 7.92e-01 2.31e-02
Telomere C-strand (Lagging Strand) Synthesis 22 7.64e-02 1.36e-01 0.28300 -0.279000 -0.047200 2.34e-02 7.01e-01
PI Metabolism 71 7.64e-02 1.36e-01 0.16600 0.130000 0.102000 5.77e-02 1.36e-01
Vasopressin regulates renal water homeostasis via Aquaporins 30 7.71e-02 1.37e-01 0.22200 0.156000 -0.158000 1.39e-01 1.35e-01
ERKs are inactivated 12 7.72e-02 1.37e-01 0.37800 0.028100 0.377000 8.66e-01 2.39e-02
Interleukin-2 family signaling 26 7.89e-02 1.40e-01 0.26400 0.250000 0.085600 2.73e-02 4.50e-01
Formation of Fibrin Clot (Clotting Cascade) 17 7.90e-02 1.40e-01 0.30100 0.092000 -0.286000 5.11e-01 4.09e-02
Metalloprotease DUBs 17 8.08e-02 1.43e-01 0.30200 -0.070800 0.294000 6.14e-01 3.62e-02
Cytosolic sensors of pathogen-associated DNA 48 8.09e-02 1.43e-01 0.19700 0.087800 0.176000 2.93e-01 3.52e-02
Laminin interactions 20 8.13e-02 1.43e-01 0.27600 0.263000 -0.083800 4.18e-02 5.17e-01
Diseases associated with glycosaminoglycan metabolism 27 8.30e-02 1.45e-01 0.23800 0.231000 -0.058100 3.78e-02 6.02e-01
IRAK2 mediated activation of TAK1 complex 10 8.30e-02 1.45e-01 0.40600 0.014700 0.405000 9.36e-01 2.65e-02
PI-3K cascade:FGFR4 10 8.30e-02 1.45e-01 0.43100 0.364000 0.231000 4.60e-02 2.06e-01
Ca2+ pathway 46 8.31e-02 1.45e-01 0.20300 0.144000 0.143000 9.13e-02 9.37e-02
Negative regulation of FGFR3 signaling 19 8.54e-02 1.49e-01 0.30800 0.134000 0.278000 3.13e-01 3.61e-02
Diseases associated with the TLR signaling cascade 18 8.58e-02 1.50e-01 0.32200 0.230000 0.226000 9.18e-02 9.76e-02
Diseases of Immune System 18 8.58e-02 1.50e-01 0.32200 0.230000 0.226000 9.18e-02 9.76e-02
Mitochondrial Fatty Acid Beta-Oxidation 27 8.77e-02 1.53e-01 0.22900 -0.189000 0.130000 9.01e-02 2.44e-01
SHC1 events in ERBB2 signaling 18 8.78e-02 1.53e-01 0.31800 0.171000 0.268000 2.10e-01 4.88e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 8.87e-02 1.54e-01 0.28200 0.162000 0.230000 1.78e-01 5.61e-02
FRS-mediated FGFR2 signaling 12 8.92e-02 1.54e-01 0.38400 0.347000 0.165000 3.75e-02 3.21e-01
VEGFR2 mediated cell proliferation 17 8.93e-02 1.54e-01 0.32600 0.274000 0.177000 5.06e-02 2.06e-01
Metabolism of carbohydrates 205 8.93e-02 1.54e-01 0.08960 0.007980 0.089200 8.44e-01 2.81e-02
DNA Damage/Telomere Stress Induced Senescence 24 9.00e-02 1.55e-01 0.27200 0.127000 0.241000 2.81e-01 4.12e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 12 9.03e-02 1.56e-01 0.34000 -0.205000 0.272000 2.19e-01 1.03e-01
G alpha (z) signalling events 30 9.11e-02 1.57e-01 0.22000 0.208000 -0.071400 4.90e-02 4.99e-01
Interferon Signaling 149 9.20e-02 1.58e-01 0.10900 0.096000 0.052700 4.36e-02 2.68e-01
Downregulation of ERBB2 signaling 22 9.20e-02 1.58e-01 0.25900 -0.058900 0.252000 6.33e-01 4.08e-02
RHO GTPases Activate WASPs and WAVEs 31 9.23e-02 1.58e-01 0.24000 0.135000 0.199000 1.92e-01 5.57e-02
Signaling by NTRK2 (TRKB) 19 9.28e-02 1.59e-01 0.30600 0.255000 0.170000 5.42e-02 2.01e-01
Aquaporin-mediated transport 31 9.28e-02 1.59e-01 0.21100 0.128000 -0.167000 2.18e-01 1.07e-01
HS-GAG degradation 13 9.38e-02 1.60e-01 0.35800 -0.095100 -0.345000 5.53e-01 3.12e-02
Triglyceride catabolism 16 9.41e-02 1.60e-01 0.29900 -0.097600 0.282000 4.99e-01 5.07e-02
BBSome-mediated cargo-targeting to cilium 18 9.60e-02 1.63e-01 0.30100 -0.294000 -0.063800 3.09e-02 6.40e-01
Cardiac conduction 78 9.69e-02 1.65e-01 0.14600 0.045300 0.139000 4.89e-01 3.38e-02
Cargo concentration in the ER 24 9.77e-02 1.66e-01 0.27000 0.224000 0.150000 5.75e-02 2.03e-01
Signaling by high-kinase activity BRAF mutants 27 9.79e-02 1.66e-01 0.25500 0.199000 0.160000 7.34e-02 1.51e-01
Retinoid metabolism and transport 23 1.02e-01 1.72e-01 0.24300 0.099400 -0.222000 4.10e-01 6.57e-02
Gene Silencing by RNA 65 1.04e-01 1.75e-01 0.16000 0.070400 0.144000 3.27e-01 4.48e-02
Effects of PIP2 hydrolysis 20 1.04e-01 1.76e-01 0.26300 -0.066600 0.255000 6.06e-01 4.86e-02
Golgi-to-ER retrograde transport 87 1.05e-01 1.77e-01 0.13900 0.066500 0.122000 2.84e-01 4.98e-02
ER Quality Control Compartment (ERQC) 19 1.06e-01 1.78e-01 0.28900 0.078100 0.278000 5.56e-01 3.58e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 14 1.07e-01 1.80e-01 0.34300 0.153000 0.307000 3.21e-01 4.70e-02
FRS-mediated FGFR1 signaling 13 1.07e-01 1.80e-01 0.35500 0.321000 0.152000 4.54e-02 3.41e-01
Integration of energy metabolism 75 1.07e-01 1.80e-01 0.14900 0.127000 0.078700 5.75e-02 2.39e-01
RNA Polymerase II Pre-transcription Events 62 1.10e-01 1.84e-01 0.16200 0.068600 0.147000 3.51e-01 4.62e-02
Insulin processing 15 1.11e-01 1.86e-01 0.29900 0.289000 -0.078300 5.28e-02 6.00e-01
Signaling by FGFR2 in disease 26 1.16e-01 1.93e-01 0.25000 0.201000 0.148000 7.55e-02 1.91e-01
Termination of O-glycan biosynthesis 13 1.17e-01 1.95e-01 0.32500 0.024300 -0.324000 8.79e-01 4.29e-02
Antiviral mechanism by IFN-stimulated genes 75 1.17e-01 1.95e-01 0.14600 0.125000 0.076300 6.17e-02 2.54e-01
MAP2K and MAPK activation 30 1.19e-01 1.98e-01 0.23100 0.186000 0.138000 7.82e-02 1.92e-01
Amyloid fiber formation 33 1.19e-01 1.98e-01 0.22100 0.162000 0.150000 1.07e-01 1.35e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 1.20e-01 1.98e-01 0.31900 -0.243000 0.207000 1.45e-01 2.14e-01
GPVI-mediated activation cascade 19 1.20e-01 1.99e-01 0.27200 0.271000 0.010100 4.07e-02 9.40e-01
Chondroitin sulfate biosynthesis 14 1.21e-01 1.99e-01 0.30400 0.294000 -0.078600 5.69e-02 6.11e-01
FRS-mediated FGFR4 signaling 12 1.21e-01 2.00e-01 0.34900 0.342000 0.069100 4.04e-02 6.79e-01
Endogenous sterols 17 1.23e-01 2.02e-01 0.26800 0.224000 -0.147000 1.10e-01 2.95e-01
Microautophagy 26 1.25e-01 2.06e-01 0.22400 -0.034300 0.222000 7.62e-01 5.06e-02
Gap-filling DNA repair synthesis and ligation in TC-NER 54 1.26e-01 2.07e-01 0.15600 -0.156000 0.016200 4.81e-02 8.37e-01
Cyclin A/B1/B2 associated events during G2/M transition 17 1.27e-01 2.08e-01 0.28200 0.001940 0.282000 9.89e-01 4.38e-02
Regulation of PLK1 Activity at G2/M Transition 74 1.27e-01 2.08e-01 0.14300 0.055300 0.131000 4.11e-01 5.08e-02
FRS-mediated FGFR3 signaling 10 1.28e-01 2.09e-01 0.38400 0.361000 0.131000 4.78e-02 4.74e-01
Activation of G protein gated Potassium channels 11 1.29e-01 2.09e-01 0.34800 0.010900 -0.348000 9.50e-01 4.59e-02
G protein gated Potassium channels 11 1.29e-01 2.09e-01 0.34800 0.010900 -0.348000 9.50e-01 4.59e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 1.29e-01 2.09e-01 0.34800 0.010900 -0.348000 9.50e-01 4.59e-02
Negative regulation of FGFR4 signaling 21 1.29e-01 2.09e-01 0.27000 0.144000 0.229000 2.53e-01 6.98e-02
tRNA processing in the nucleus 50 1.29e-01 2.09e-01 0.15400 -0.113000 0.104000 1.66e-01 2.03e-01
TP53 Regulates Transcription of Death Receptors and Ligands 10 1.31e-01 2.12e-01 0.34400 0.286000 -0.190000 1.17e-01 2.97e-01
ZBP1(DAI) mediated induction of type I IFNs 16 1.31e-01 2.13e-01 0.30700 0.268000 0.150000 6.37e-02 3.00e-01
Stimuli-sensing channels 52 1.32e-01 2.13e-01 0.15100 -0.085800 0.124000 2.85e-01 1.23e-01
Unfolded Protein Response (UPR) 74 1.35e-01 2.19e-01 0.14100 0.060400 0.128000 3.69e-01 5.82e-02
ISG15 antiviral mechanism 69 1.36e-01 2.20e-01 0.14800 0.114000 0.095200 1.03e-01 1.72e-01
Signal amplification 19 1.37e-01 2.21e-01 0.25900 0.257000 -0.024300 5.21e-02 8.55e-01
Synthesis of PIPs at the Golgi membrane 15 1.37e-01 2.21e-01 0.31200 0.280000 0.137000 6.02e-02 3.59e-01
Signaling by Retinoic Acid 33 1.38e-01 2.21e-01 0.20800 0.068700 0.196000 4.95e-01 5.15e-02
Nonhomologous End-Joining (NHEJ) 33 1.38e-01 2.21e-01 0.21400 0.157000 0.145000 1.18e-01 1.50e-01
Activation of SMO 13 1.38e-01 2.21e-01 0.30400 0.090500 -0.291000 5.72e-01 6.98e-02
SHC-mediated cascade:FGFR2 10 1.38e-01 2.22e-01 0.37800 0.351000 0.143000 5.50e-02 4.35e-01
Nitric oxide stimulates guanylate cyclase 17 1.39e-01 2.22e-01 0.26100 0.127000 -0.228000 3.65e-01 1.04e-01
G alpha (s) signalling events 66 1.40e-01 2.24e-01 0.14700 -0.056400 -0.136000 4.29e-01 5.63e-02
Glycosaminoglycan metabolism 80 1.41e-01 2.24e-01 0.12100 0.111000 -0.048100 8.61e-02 4.58e-01
PKA-mediated phosphorylation of CREB 17 1.41e-01 2.25e-01 0.26000 0.230000 -0.121000 1.01e-01 3.87e-01
Metabolism of fat-soluble vitamins 26 1.42e-01 2.26e-01 0.21000 0.098600 -0.185000 3.85e-01 1.02e-01
Glycogen breakdown (glycogenolysis) 13 1.43e-01 2.26e-01 0.32600 0.095100 0.312000 5.53e-01 5.16e-02
DAP12 signaling 20 1.43e-01 2.26e-01 0.25000 0.249000 -0.021800 5.44e-02 8.66e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 55 1.43e-01 2.27e-01 0.15800 0.044000 0.152000 5.73e-01 5.13e-02
Post NMDA receptor activation events 45 1.44e-01 2.28e-01 0.17800 0.078000 0.160000 3.66e-01 6.34e-02
EPHA-mediated growth cone collapse 14 1.45e-01 2.29e-01 0.29400 0.289000 -0.051700 6.12e-02 7.38e-01
NRIF signals cell death from the nucleus 12 1.47e-01 2.32e-01 0.31900 -0.028800 0.318000 8.63e-01 5.64e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 16 1.49e-01 2.35e-01 0.26700 -0.092400 0.251000 5.22e-01 8.23e-02
Sphingolipid de novo biosynthesis 31 1.51e-01 2.38e-01 0.21500 0.159000 0.144000 1.24e-01 1.65e-01
Ion transport by P-type ATPases 36 1.53e-01 2.40e-01 0.19900 0.148000 0.134000 1.25e-01 1.65e-01
ABC transporters in lipid homeostasis 11 1.54e-01 2.41e-01 0.35700 -0.304000 -0.187000 8.13e-02 2.83e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 12 1.54e-01 2.42e-01 0.30700 0.291000 -0.098100 8.12e-02 5.57e-01
Role of LAT2/NTAL/LAB on calcium mobilization 12 1.54e-01 2.42e-01 0.33700 0.307000 0.140000 6.56e-02 4.01e-01
Interleukin receptor SHC signaling 15 1.56e-01 2.45e-01 0.29900 0.277000 0.113000 6.32e-02 4.48e-01
TNFR1-induced proapoptotic signaling 12 1.57e-01 2.45e-01 0.32500 0.052000 0.321000 7.55e-01 5.42e-02
Alpha-protein kinase 1 signaling pathway 11 1.57e-01 2.45e-01 0.31500 -0.140000 0.282000 4.21e-01 1.05e-01
Translesion Synthesis by POLH 18 1.58e-01 2.45e-01 0.24400 -0.205000 0.133000 1.32e-01 3.30e-01
Interleukin-20 family signaling 14 1.58e-01 2.45e-01 0.28500 0.278000 -0.064700 7.22e-02 6.75e-01
Cleavage of the damaged pyrimidine 16 1.58e-01 2.45e-01 0.25800 -0.196000 0.168000 1.75e-01 2.46e-01
Depyrimidination 16 1.58e-01 2.45e-01 0.25800 -0.196000 0.168000 1.75e-01 2.46e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 16 1.58e-01 2.45e-01 0.25800 -0.196000 0.168000 1.75e-01 2.46e-01
Interferon alpha/beta signaling 44 1.60e-01 2.48e-01 0.16500 0.165000 -0.000205 5.81e-02 9.98e-01
Synthesis of PIPs at the late endosome membrane 11 1.61e-01 2.49e-01 0.35000 0.309000 0.164000 7.56e-02 3.48e-01
Basigin interactions 17 1.62e-01 2.51e-01 0.26100 -0.030200 0.259000 8.29e-01 6.48e-02
Metabolism of steroid hormones 16 1.63e-01 2.52e-01 0.25700 -0.220000 0.134000 1.28e-01 3.55e-01
GRB2 events in ERBB2 signaling 12 1.64e-01 2.53e-01 0.32800 0.105000 0.311000 5.27e-01 6.25e-02
SHC-mediated cascade:FGFR1 11 1.65e-01 2.54e-01 0.34400 0.319000 0.129000 6.69e-02 4.58e-01
SHC-mediated cascade:FGFR4 10 1.68e-01 2.58e-01 0.34600 0.344000 0.027000 5.93e-02 8.82e-01
Interaction between L1 and Ankyrins 16 1.70e-01 2.60e-01 0.28900 0.237000 0.165000 1.01e-01 2.52e-01
Base-Excision Repair, AP Site Formation 18 1.70e-01 2.60e-01 0.24200 -0.222000 0.097200 1.04e-01 4.75e-01
Spry regulation of FGF signaling 16 1.70e-01 2.60e-01 0.28400 0.109000 0.262000 4.50e-01 7.00e-02
ROS and RNS production in phagocytes 23 1.70e-01 2.60e-01 0.22000 0.033800 -0.217000 7.79e-01 7.12e-02
RHO GTPases activate CIT 18 1.71e-01 2.61e-01 0.26700 0.245000 0.107000 7.20e-02 4.31e-01
Keratinization 13 1.72e-01 2.61e-01 0.29500 0.021400 -0.294000 8.94e-01 6.62e-02
KSRP (KHSRP) binds and destabilizes mRNA 14 1.74e-01 2.64e-01 0.29800 0.085000 0.285000 5.82e-01 6.48e-02
Kinesins 23 1.74e-01 2.64e-01 0.21100 0.106000 -0.182000 3.78e-01 1.30e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 22 1.74e-01 2.64e-01 0.21500 -0.119000 0.179000 3.34e-01 1.46e-01
Trafficking of AMPA receptors 22 1.74e-01 2.64e-01 0.21500 -0.119000 0.179000 3.34e-01 1.46e-01
Cytochrome P450 - arranged by substrate type 25 1.74e-01 2.64e-01 0.20400 0.080800 -0.187000 4.84e-01 1.05e-01
FGFR2 alternative splicing 20 1.76e-01 2.66e-01 0.23900 0.000908 0.239000 9.94e-01 6.47e-02
Initiation of Nuclear Envelope Reformation 12 1.76e-01 2.66e-01 0.32900 0.182000 0.275000 2.76e-01 9.96e-02
Nuclear Envelope Reassembly 12 1.76e-01 2.66e-01 0.32900 0.182000 0.275000 2.76e-01 9.96e-02
Uptake and function of anthrax toxins 11 1.77e-01 2.66e-01 0.34200 0.297000 0.171000 8.85e-02 3.27e-01
ERBB2 Regulates Cell Motility 11 1.77e-01 2.67e-01 0.30500 -0.136000 0.273000 4.36e-01 1.17e-01
Ion channel transport 102 1.78e-01 2.68e-01 0.10400 -0.008270 0.104000 8.85e-01 6.97e-02
MHC class II antigen presentation 75 1.79e-01 2.69e-01 0.13200 0.095600 0.091300 1.53e-01 1.72e-01
Calnexin/calreticulin cycle 23 1.80e-01 2.69e-01 0.22800 0.046500 0.223000 6.99e-01 6.46e-02
Netrin-1 signaling 38 1.83e-01 2.74e-01 0.18200 0.159000 0.089200 9.03e-02 3.42e-01
Heparan sulfate/heparin (HS-GAG) metabolism 31 1.85e-01 2.77e-01 0.18900 0.000266 -0.189000 9.98e-01 6.88e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 1.85e-01 2.77e-01 0.29200 0.192000 0.220000 1.99e-01 1.40e-01
RAB geranylgeranylation 41 1.85e-01 2.77e-01 0.17000 0.040400 0.165000 6.55e-01 6.80e-02
Interleukin-37 signaling 17 1.86e-01 2.77e-01 0.24600 0.238000 -0.062000 8.89e-02 6.58e-01
WNT5A-dependent internalization of FZD4 12 1.86e-01 2.77e-01 0.30900 0.046600 0.306000 7.80e-01 6.68e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 10 1.87e-01 2.78e-01 0.35700 -0.250000 -0.254000 1.71e-01 1.64e-01
Phosphorylation of the APC/C 16 1.88e-01 2.78e-01 0.24600 -0.151000 0.194000 2.96e-01 1.79e-01
Intrinsic Pathway of Fibrin Clot Formation 11 1.88e-01 2.78e-01 0.31900 -0.026200 -0.318000 8.81e-01 6.79e-02
Formation of the cornified envelope 12 1.88e-01 2.78e-01 0.29100 0.087900 -0.277000 5.98e-01 9.65e-02
Negative regulation of MET activity 18 1.89e-01 2.80e-01 0.25600 0.071600 0.246000 5.99e-01 7.13e-02
Peroxisomal lipid metabolism 22 1.90e-01 2.81e-01 0.22400 -0.224000 -0.013100 6.94e-02 9.16e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 21 1.93e-01 2.84e-01 0.23700 0.225000 0.074100 7.48e-02 5.57e-01
Processing and activation of SUMO 10 1.93e-01 2.84e-01 0.34500 0.129000 0.320000 4.79e-01 7.98e-02
DNA Damage Bypass 42 1.94e-01 2.85e-01 0.15100 -0.089600 0.121000 3.15e-01 1.75e-01
Downregulation of ERBB2:ERBB3 signaling 12 1.94e-01 2.85e-01 0.28400 -0.256000 0.124000 1.25e-01 4.57e-01
Lagging Strand Synthesis 20 1.94e-01 2.85e-01 0.23200 -0.232000 -0.003100 7.25e-02 9.81e-01
Collagen degradation 18 1.94e-01 2.85e-01 0.23300 0.089000 -0.215000 5.14e-01 1.14e-01
Regulation of TP53 Activity through Phosphorylation 72 1.95e-01 2.85e-01 0.13200 0.090700 0.095400 1.84e-01 1.62e-01
RHO GTPases Activate ROCKs 19 1.96e-01 2.87e-01 0.25400 0.208000 0.146000 1.17e-01 2.71e-01
Mitochondrial tRNA aminoacylation 20 1.97e-01 2.87e-01 0.22600 -0.223000 0.036300 8.44e-02 7.79e-01
Neutrophil degranulation 318 1.97e-01 2.88e-01 0.06110 0.019600 0.057900 5.50e-01 7.73e-02
PCNA-Dependent Long Patch Base Excision Repair 18 1.98e-01 2.89e-01 0.24900 -0.245000 -0.046200 7.24e-02 7.34e-01
Meiotic recombination 20 1.99e-01 2.90e-01 0.24200 0.090700 0.224000 4.83e-01 8.29e-02
Diseases of metabolism 64 2.02e-01 2.94e-01 0.12000 -0.096200 0.072500 1.84e-01 3.16e-01
Activation of RAC1 10 2.03e-01 2.95e-01 0.33500 0.092400 0.322000 6.13e-01 7.76e-02
The role of Nef in HIV-1 replication and disease pathogenesis 20 2.06e-01 2.99e-01 0.22100 -0.048600 0.215000 7.07e-01 9.53e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 71 2.10e-01 3.05e-01 0.11300 0.071000 -0.087700 3.02e-01 2.02e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 23 2.11e-01 3.05e-01 0.21400 -0.213000 -0.026700 7.78e-02 8.25e-01
Pyruvate metabolism 26 2.14e-01 3.09e-01 0.19600 -0.008980 0.196000 9.37e-01 8.44e-02
IRAK1 recruits IKK complex 10 2.15e-01 3.09e-01 0.32900 0.318000 0.084100 8.18e-02 6.45e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 2.15e-01 3.09e-01 0.32900 0.318000 0.084100 8.18e-02 6.45e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.16e-01 3.12e-01 0.29400 -0.057100 0.289000 7.43e-01 9.75e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 63 2.21e-01 3.17e-01 0.13400 -0.116000 -0.067600 1.13e-01 3.54e-01
Endosomal/Vacuolar pathway 10 2.22e-01 3.19e-01 0.30300 0.293000 -0.079200 1.09e-01 6.65e-01
PKA activation 15 2.24e-01 3.22e-01 0.24200 0.214000 -0.113000 1.52e-01 4.48e-01
Recognition of DNA damage by PCNA-containing replication complex 27 2.26e-01 3.24e-01 0.17800 -0.134000 0.117000 2.28e-01 2.91e-01
Voltage gated Potassium channels 10 2.27e-01 3.24e-01 0.29500 0.254000 -0.149000 1.65e-01 4.14e-01
Post-translational protein phosphorylation 65 2.27e-01 3.24e-01 0.11500 0.084600 -0.077700 2.39e-01 2.79e-01
Transport of vitamins, nucleosides, and related molecules 25 2.27e-01 3.25e-01 0.20300 -0.198000 -0.046800 8.67e-02 6.86e-01
Cellular hexose transport 10 2.28e-01 3.25e-01 0.33400 -0.270000 -0.196000 1.39e-01 2.83e-01
SHC1 events in ERBB4 signaling 10 2.28e-01 3.25e-01 0.33500 0.233000 0.240000 2.01e-01 1.88e-01
Signaling by Leptin 10 2.29e-01 3.26e-01 0.32500 0.307000 0.105000 9.28e-02 5.65e-01
Regulation of innate immune responses to cytosolic DNA 11 2.29e-01 3.26e-01 0.30800 -0.295000 -0.085500 8.99e-02 6.23e-01
Sema4D in semaphorin signaling 23 2.31e-01 3.27e-01 0.22000 0.174000 0.133000 1.48e-01 2.68e-01
Termination of translesion DNA synthesis 27 2.31e-01 3.28e-01 0.18700 -0.187000 0.010800 9.32e-02 9.23e-01
Caspase-mediated cleavage of cytoskeletal proteins 11 2.32e-01 3.29e-01 0.31700 0.200000 0.246000 2.51e-01 1.58e-01
Diseases associated with N-glycosylation of proteins 14 2.35e-01 3.32e-01 0.27000 -0.260000 -0.073100 9.23e-02 6.36e-01
SUMOylation of chromatin organization proteins 55 2.35e-01 3.32e-01 0.14100 0.109000 0.090400 1.64e-01 2.47e-01
rRNA modification in the nucleus and cytosol 47 2.37e-01 3.34e-01 0.13300 -0.097800 0.090200 2.46e-01 2.85e-01
Arachidonic acid metabolism 23 2.40e-01 3.38e-01 0.21700 -0.139000 -0.167000 2.49e-01 1.67e-01
Carboxyterminal post-translational modifications of tubulin 23 2.45e-01 3.45e-01 0.20600 -0.042600 -0.202000 7.24e-01 9.43e-02
Activation of kainate receptors upon glutamate binding 19 2.52e-01 3.54e-01 0.23400 -0.140000 -0.187000 2.91e-01 1.57e-01
O-linked glycosylation of mucins 29 2.52e-01 3.54e-01 0.16700 0.142000 -0.086300 1.84e-01 4.22e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 34 2.55e-01 3.58e-01 0.15600 -0.147000 0.051700 1.38e-01 6.02e-01
Nucleobase biosynthesis 15 2.57e-01 3.60e-01 0.25700 -0.234000 -0.107000 1.16e-01 4.74e-01
Sema4D induced cell migration and growth-cone collapse 19 2.60e-01 3.64e-01 0.22400 0.215000 0.065000 1.05e-01 6.24e-01
Gap junction trafficking and regulation 15 2.61e-01 3.65e-01 0.24900 0.244000 0.051700 1.02e-01 7.29e-01
SLC-mediated transmembrane transport 131 2.61e-01 3.65e-01 0.08450 -0.083000 -0.016100 1.02e-01 7.51e-01
Surfactant metabolism 10 2.62e-01 3.65e-01 0.31100 -0.290000 -0.112000 1.12e-01 5.40e-01
RHO GTPases activate PAKs 20 2.64e-01 3.67e-01 0.22200 0.198000 0.099400 1.25e-01 4.42e-01
Prolactin receptor signaling 10 2.64e-01 3.68e-01 0.30000 0.035900 0.298000 8.44e-01 1.03e-01
Chemokine receptors bind chemokines 12 2.67e-01 3.70e-01 0.25200 0.175000 -0.181000 2.94e-01 2.78e-01
TP53 Regulates Transcription of Cell Cycle Genes 37 2.69e-01 3.73e-01 0.16300 0.083500 0.140000 3.80e-01 1.41e-01
Complement cascade 19 2.69e-01 3.74e-01 0.21200 0.006860 -0.212000 9.59e-01 1.10e-01
Signal regulatory protein family interactions 11 2.72e-01 3.77e-01 0.26400 0.122000 -0.234000 4.83e-01 1.79e-01
Trafficking of GluR2-containing AMPA receptors 12 2.72e-01 3.77e-01 0.25200 -0.119000 0.222000 4.75e-01 1.82e-01
FCERI mediated Ca+2 mobilization 21 2.73e-01 3.77e-01 0.21600 0.133000 0.171000 2.92e-01 1.76e-01
Activation of ATR in response to replication stress 26 2.73e-01 3.77e-01 0.17500 -0.169000 0.044300 1.35e-01 6.96e-01
Listeria monocytogenes entry into host cells 16 2.76e-01 3.81e-01 0.24400 0.120000 0.213000 4.06e-01 1.41e-01
VLDLR internalisation and degradation 11 2.78e-01 3.84e-01 0.27800 0.013400 0.277000 9.39e-01 1.11e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 12 2.80e-01 3.85e-01 0.27200 0.064200 0.265000 7.00e-01 1.12e-01
Metabolism of cofactors 16 2.81e-01 3.86e-01 0.22700 -0.010400 0.226000 9.43e-01 1.17e-01
Regulation of TP53 Activity through Acetylation 29 2.81e-01 3.86e-01 0.18000 0.158000 0.086300 1.41e-01 4.22e-01
Nuclear signaling by ERBB4 21 2.83e-01 3.87e-01 0.20500 0.047900 0.199000 7.04e-01 1.14e-01
Sema3A PAK dependent Axon repulsion 14 2.85e-01 3.90e-01 0.25400 0.239000 0.084800 1.22e-01 5.83e-01
TRAF6 mediated NF-kB activation 18 2.87e-01 3.92e-01 0.22900 0.177000 0.146000 1.94e-01 2.84e-01
SUMOylation of transcription factors 15 2.89e-01 3.95e-01 0.25000 0.195000 0.157000 1.91e-01 2.94e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 2.94e-01 4.01e-01 0.22100 0.157000 0.155000 2.35e-01 2.41e-01
Processive synthesis on the lagging strand 15 2.94e-01 4.01e-01 0.23400 -0.233000 -0.021100 1.18e-01 8.87e-01
Class I peroxisomal membrane protein import 15 2.95e-01 4.01e-01 0.22400 -0.056800 0.216000 7.04e-01 1.47e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 22 2.95e-01 4.01e-01 0.19600 -0.192000 -0.036400 1.18e-01 7.68e-01
Potassium Channels 34 2.95e-01 4.01e-01 0.14500 0.068000 -0.128000 4.93e-01 1.95e-01
PKA activation in glucagon signalling 15 2.96e-01 4.01e-01 0.21800 0.187000 -0.111000 2.10e-01 4.55e-01
Opioid Signalling 68 2.98e-01 4.03e-01 0.11700 0.085400 0.079400 2.24e-01 2.58e-01
Transcriptional regulation by small RNAs 45 2.98e-01 4.03e-01 0.14300 0.089600 0.111000 2.99e-01 1.97e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 16 2.98e-01 4.03e-01 0.21900 -0.029000 0.217000 8.41e-01 1.34e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 22 3.03e-01 4.09e-01 0.18100 -0.057200 0.172000 6.43e-01 1.62e-01
Signalling to RAS 17 3.03e-01 4.09e-01 0.22200 0.215000 0.056100 1.25e-01 6.89e-01
Interferon gamma signaling 63 3.04e-01 4.10e-01 0.10600 0.098500 -0.040200 1.77e-01 5.81e-01
Depolymerisation of the Nuclear Lamina 12 3.05e-01 4.10e-01 0.27100 0.235000 0.135000 1.58e-01 4.18e-01
Long-term potentiation 13 3.06e-01 4.12e-01 0.23500 -0.072600 0.223000 6.50e-01 1.63e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 20 3.11e-01 4.17e-01 0.21100 0.160000 0.137000 2.15e-01 2.90e-01
eNOS activation 11 3.14e-01 4.21e-01 0.28300 0.216000 0.182000 2.15e-01 2.95e-01
Signal transduction by L1 17 3.15e-01 4.23e-01 0.21500 0.033400 0.213000 8.12e-01 1.29e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 22 3.17e-01 4.25e-01 0.18800 0.022800 0.187000 8.53e-01 1.30e-01
Mitotic Telophase/Cytokinesis 10 3.19e-01 4.27e-01 0.28400 0.079100 0.273000 6.65e-01 1.35e-01
Josephin domain DUBs 11 3.24e-01 4.33e-01 0.25800 -0.010400 0.257000 9.52e-01 1.40e-01
EPH-ephrin mediated repulsion of cells 31 3.28e-01 4.38e-01 0.16200 0.148000 0.066600 1.55e-01 5.21e-01
TP53 Regulates Transcription of DNA Repair Genes 48 3.31e-01 4.41e-01 0.12500 0.017100 0.124000 8.38e-01 1.37e-01
Cristae formation 10 3.31e-01 4.41e-01 0.25400 -0.221000 0.126000 2.26e-01 4.92e-01
EPHB-mediated forward signaling 29 3.32e-01 4.41e-01 0.16900 0.093900 0.141000 3.82e-01 1.90e-01
MET activates PTK2 signaling 14 3.32e-01 4.41e-01 0.23900 0.221000 0.088900 1.51e-01 5.65e-01
Regulation of IFNA signaling 11 3.32e-01 4.41e-01 0.27500 0.223000 0.160000 2.00e-01 3.58e-01
Interactions of Vpr with host cellular proteins 34 3.33e-01 4.41e-01 0.14200 -0.030800 0.138000 7.56e-01 1.63e-01
Processing of DNA double-strand break ends 53 3.34e-01 4.42e-01 0.11500 -0.008430 0.115000 9.15e-01 1.47e-01
Synthesis of substrates in N-glycan biosythesis 50 3.37e-01 4.46e-01 0.12800 -0.077500 -0.102000 3.44e-01 2.12e-01
VxPx cargo-targeting to cilium 16 3.39e-01 4.48e-01 0.21000 0.210000 -0.002670 1.46e-01 9.85e-01
Amino acids regulate mTORC1 40 3.43e-01 4.51e-01 0.12400 -0.079000 0.096000 3.88e-01 2.94e-01
HIV Transcription Initiation 36 3.44e-01 4.51e-01 0.14100 0.009980 0.141000 9.18e-01 1.45e-01
RNA Polymerase II HIV Promoter Escape 36 3.44e-01 4.51e-01 0.14100 0.009980 0.141000 9.18e-01 1.45e-01
RNA Polymerase II Promoter Escape 36 3.44e-01 4.51e-01 0.14100 0.009980 0.141000 9.18e-01 1.45e-01
RNA Polymerase II Transcription Initiation 36 3.44e-01 4.51e-01 0.14100 0.009980 0.141000 9.18e-01 1.45e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 36 3.44e-01 4.51e-01 0.14100 0.009980 0.141000 9.18e-01 1.45e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 36 3.44e-01 4.51e-01 0.14100 0.009980 0.141000 9.18e-01 1.45e-01
Cleavage of the damaged purine 11 3.46e-01 4.52e-01 0.23800 -0.108000 0.212000 5.34e-01 2.23e-01
Depurination 11 3.46e-01 4.52e-01 0.23800 -0.108000 0.212000 5.34e-01 2.23e-01
Recognition and association of DNA glycosylase with site containing an affected purine 11 3.46e-01 4.52e-01 0.23800 -0.108000 0.212000 5.34e-01 2.23e-01
Platelet sensitization by LDL 15 3.49e-01 4.55e-01 0.23000 0.143000 0.181000 3.37e-01 2.26e-01
Formation of the Early Elongation Complex 25 3.49e-01 4.55e-01 0.16500 -0.165000 0.006190 1.53e-01 9.57e-01
Formation of the HIV-1 Early Elongation Complex 25 3.49e-01 4.55e-01 0.16500 -0.165000 0.006190 1.53e-01 9.57e-01
Phospholipid metabolism 155 3.51e-01 4.57e-01 0.07140 0.037600 0.060700 4.21e-01 1.93e-01
Plasma lipoprotein assembly, remodeling, and clearance 48 3.60e-01 4.68e-01 0.11900 0.119000 0.006100 1.54e-01 9.42e-01
NF-kB is activated and signals survival 11 3.62e-01 4.69e-01 0.23800 -0.058300 0.231000 7.38e-01 1.84e-01
Homology Directed Repair 81 3.62e-01 4.69e-01 0.08550 -0.049900 0.069400 4.38e-01 2.81e-01
G beta:gamma signalling through PLC beta 12 3.63e-01 4.69e-01 0.24600 -0.084900 -0.231000 6.11e-01 1.65e-01
Presynaptic function of Kainate receptors 12 3.63e-01 4.69e-01 0.24600 -0.084900 -0.231000 6.11e-01 1.65e-01
SIRT1 negatively regulates rRNA expression 11 3.68e-01 4.75e-01 0.26100 0.218000 0.144000 2.11e-01 4.10e-01
Transcription of the HIV genome 54 3.68e-01 4.75e-01 0.11700 0.058500 0.102000 4.57e-01 1.96e-01
Processive synthesis on the C-strand of the telomere 11 3.69e-01 4.76e-01 0.25700 -0.234000 -0.107000 1.79e-01 5.37e-01
Repression of WNT target genes 12 3.70e-01 4.77e-01 0.24600 0.223000 0.103000 1.80e-01 5.36e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 14 3.73e-01 4.80e-01 0.22600 0.208000 0.088700 1.77e-01 5.65e-01
tRNA Aminoacylation 39 3.74e-01 4.80e-01 0.12500 -0.122000 0.028900 1.89e-01 7.55e-01
Gap junction trafficking 13 3.75e-01 4.82e-01 0.23900 0.181000 0.157000 2.60e-01 3.27e-01
Removal of the Flap Intermediate 14 3.83e-01 4.91e-01 0.20700 -0.204000 0.035600 1.86e-01 8.18e-01
E2F mediated regulation of DNA replication 17 3.84e-01 4.93e-01 0.20400 0.098600 0.179000 4.82e-01 2.02e-01
Nuclear Envelope Breakdown 47 3.85e-01 4.93e-01 0.12300 0.106000 0.062800 2.09e-01 4.57e-01
CS/DS degradation 10 3.94e-01 5.03e-01 0.24000 0.054100 -0.234000 7.67e-01 2.01e-01
Regulation of Complement cascade 16 3.96e-01 5.06e-01 0.18300 0.103000 -0.152000 4.76e-01 2.94e-01
STING mediated induction of host immune responses 12 3.98e-01 5.08e-01 0.23300 -0.062000 -0.224000 7.10e-01 1.79e-01
TBC/RABGAPs 38 3.99e-01 5.08e-01 0.13500 0.070800 0.114000 4.50e-01 2.23e-01
Purine ribonucleoside monophosphate biosynthesis 12 3.99e-01 5.09e-01 0.22500 -0.224000 -0.005280 1.78e-01 9.75e-01
RNA Polymerase III Transcription Initiation 29 4.03e-01 5.13e-01 0.14200 -0.006040 0.142000 9.55e-01 1.85e-01
Metabolism of nitric oxide: eNOS activation and regulation 14 4.04e-01 5.13e-01 0.21800 0.196000 0.096000 2.04e-01 5.34e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 65 4.06e-01 5.15e-01 0.08970 -0.054700 0.071100 4.46e-01 3.22e-01
Chondroitin sulfate/dermatan sulfate metabolism 35 4.06e-01 5.16e-01 0.12200 0.067500 -0.102000 4.90e-01 2.96e-01
Growth hormone receptor signaling 16 4.09e-01 5.19e-01 0.20400 0.104000 0.175000 4.72e-01 2.24e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 22 4.12e-01 5.21e-01 0.17400 0.102000 0.141000 4.07e-01 2.52e-01
Zinc transporters 10 4.13e-01 5.21e-01 0.23000 0.087700 -0.212000 6.31e-01 2.45e-01
G-protein mediated events 44 4.15e-01 5.23e-01 0.10900 0.097200 -0.048800 2.65e-01 5.76e-01
Regulation of insulin secretion 49 4.15e-01 5.23e-01 0.11300 0.108000 0.032800 1.91e-01 6.91e-01
Nicotinate metabolism 23 4.15e-01 5.23e-01 0.16700 -0.153000 -0.066600 2.04e-01 5.80e-01
Branched-chain amino acid catabolism 18 4.23e-01 5.32e-01 0.17100 0.164000 -0.048500 2.29e-01 7.22e-01
Phase 2 - plateau phase 13 4.27e-01 5.37e-01 0.20400 -0.203000 0.019800 2.04e-01 9.02e-01
Early Phase of HIV Life Cycle 13 4.29e-01 5.39e-01 0.19800 -0.188000 0.063600 2.41e-01 6.91e-01
TICAM1-dependent activation of IRF3/IRF7 11 4.30e-01 5.40e-01 0.23100 0.051200 0.225000 7.69e-01 1.96e-01
SUMOylation of RNA binding proteins 45 4.32e-01 5.42e-01 0.11800 0.056900 0.103000 5.09e-01 2.32e-01
SLC transporter disorders 59 4.33e-01 5.42e-01 0.09410 -0.018900 0.092200 8.02e-01 2.21e-01
Glucagon signaling in metabolic regulation 23 4.37e-01 5.46e-01 0.14500 0.077700 -0.122000 5.19e-01 3.11e-01
Pink/Parkin Mediated Mitophagy 17 4.37e-01 5.46e-01 0.16900 -0.087400 0.144000 5.33e-01 3.04e-01
Glucagon-type ligand receptors 14 4.39e-01 5.48e-01 0.21100 -0.147000 -0.151000 3.40e-01 3.27e-01
Activated NTRK2 signals through FRS2 and FRS3 10 4.41e-01 5.50e-01 0.23800 0.233000 0.048800 2.02e-01 7.89e-01
Neuronal System 197 4.42e-01 5.50e-01 0.04960 0.042800 -0.025100 3.02e-01 5.44e-01
Metabolism of non-coding RNA 46 4.45e-01 5.53e-01 0.10300 -0.040700 0.094100 6.33e-01 2.70e-01
snRNP Assembly 46 4.45e-01 5.53e-01 0.10300 -0.040700 0.094100 6.33e-01 2.70e-01
InlB-mediated entry of Listeria monocytogenes into host cell 13 4.47e-01 5.55e-01 0.19900 -0.020200 0.198000 9.00e-01 2.17e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 19 4.50e-01 5.58e-01 0.16600 0.003290 0.166000 9.80e-01 2.09e-01
DNA Double-Strand Break Repair 107 4.51e-01 5.58e-01 0.07030 0.002050 0.070300 9.71e-01 2.10e-01
Regulation of TP53 Activity through Association with Co-factors 11 4.51e-01 5.58e-01 0.21500 0.214000 -0.018400 2.19e-01 9.16e-01
Formation of RNA Pol II elongation complex 43 4.52e-01 5.58e-01 0.11000 0.001610 0.110000 9.85e-01 2.11e-01
RNA Polymerase II Transcription Elongation 43 4.52e-01 5.58e-01 0.11000 0.001610 0.110000 9.85e-01 2.11e-01
Metabolism of folate and pterines 13 4.53e-01 5.59e-01 0.19200 0.063700 -0.181000 6.91e-01 2.59e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 28 4.56e-01 5.62e-01 0.14500 -0.082700 -0.119000 4.49e-01 2.74e-01
Mismatch Repair 13 4.58e-01 5.64e-01 0.19600 0.013000 -0.196000 9.35e-01 2.21e-01
SUMOylation of DNA damage response and repair proteins 71 4.59e-01 5.64e-01 0.08980 0.037600 0.081500 5.84e-01 2.35e-01
Condensation of Prophase Chromosomes 15 4.62e-01 5.68e-01 0.17300 0.143000 -0.096800 3.37e-01 5.16e-01
Triglyceride metabolism 24 4.65e-01 5.70e-01 0.13800 -0.053400 0.127000 6.51e-01 2.80e-01
RNA Pol II CTD phosphorylation and interaction with CE 20 4.65e-01 5.70e-01 0.15100 -0.136000 0.065200 2.94e-01 6.14e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 20 4.65e-01 5.70e-01 0.15100 -0.136000 0.065200 2.94e-01 6.14e-01
Gap junction degradation 10 4.67e-01 5.72e-01 0.23700 0.110000 0.210000 5.46e-01 2.50e-01
Role of phospholipids in phagocytosis 16 4.69e-01 5.73e-01 0.18900 0.156000 0.107000 2.82e-01 4.60e-01
Metabolism of porphyrins 13 4.69e-01 5.73e-01 0.19000 -0.185000 0.042500 2.49e-01 7.91e-01
CASP8 activity is inhibited 10 4.70e-01 5.73e-01 0.23500 -0.103000 -0.212000 5.72e-01 2.47e-01
Dimerization of procaspase-8 10 4.70e-01 5.73e-01 0.23500 -0.103000 -0.212000 5.72e-01 2.47e-01
Regulation by c-FLIP 10 4.70e-01 5.73e-01 0.23500 -0.103000 -0.212000 5.72e-01 2.47e-01
Glyoxylate metabolism and glycine degradation 21 4.71e-01 5.74e-01 0.15300 -0.004350 0.153000 9.72e-01 2.26e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 17 4.72e-01 5.74e-01 0.16500 0.038900 -0.160000 7.81e-01 2.52e-01
Peptide hormone metabolism 41 4.73e-01 5.74e-01 0.10300 0.061500 -0.082500 4.96e-01 3.61e-01
Deposition of new CENPA-containing nucleosomes at the centromere 20 4.77e-01 5.78e-01 0.15200 -0.149000 0.028000 2.48e-01 8.28e-01
Nucleosome assembly 20 4.77e-01 5.78e-01 0.15200 -0.149000 0.028000 2.48e-01 8.28e-01
Regulation of TP53 Activity through Methylation 16 4.78e-01 5.78e-01 0.18700 -0.135000 -0.130000 3.49e-01 3.70e-01
RNA Polymerase III Chain Elongation 13 4.79e-01 5.79e-01 0.19800 0.036900 0.194000 8.18e-01 2.26e-01
Fatty acid metabolism 105 4.80e-01 5.80e-01 0.06670 -0.066100 0.008880 2.43e-01 8.75e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 21 4.81e-01 5.81e-01 0.14900 -0.014400 0.148000 9.09e-01 2.39e-01
Activation of NMDA receptors and postsynaptic events 52 4.82e-01 5.81e-01 0.10200 0.050700 0.088800 5.27e-01 2.69e-01
Pentose phosphate pathway 11 4.84e-01 5.83e-01 0.20700 -0.007550 0.207000 9.65e-01 2.35e-01
Inactivation, recovery and regulation of the phototransduction cascade 15 4.85e-01 5.84e-01 0.17000 -0.061200 0.159000 6.82e-01 2.88e-01
LDL clearance 17 4.86e-01 5.84e-01 0.17800 0.089000 0.154000 5.25e-01 2.72e-01
Metal ion SLC transporters 14 4.89e-01 5.88e-01 0.17200 0.131000 -0.111000 3.97e-01 4.72e-01
IRF3-mediated induction of type I IFN 10 4.90e-01 5.88e-01 0.22500 -0.066000 -0.215000 7.18e-01 2.39e-01
Negative regulators of DDX58/IFIH1 signaling 33 4.94e-01 5.92e-01 0.11400 -0.036400 0.108000 7.17e-01 2.84e-01
Reduction of cytosolic Ca++ levels 10 4.94e-01 5.92e-01 0.20200 0.157000 -0.127000 3.91e-01 4.87e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 76 4.96e-01 5.93e-01 0.07390 -0.034200 0.065500 6.07e-01 3.24e-01
Bile acid and bile salt metabolism 24 5.03e-01 6.00e-01 0.13700 -0.000496 0.137000 9.97e-01 2.46e-01
Synthesis of bile acids and bile salts 24 5.03e-01 6.00e-01 0.13700 -0.000496 0.137000 9.97e-01 2.46e-01
Glutamate and glutamine metabolism 11 5.04e-01 6.01e-01 0.20600 0.204000 0.031500 2.42e-01 8.56e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 31 5.09e-01 6.05e-01 0.11300 -0.101000 0.051000 3.29e-01 6.23e-01
HIV Transcription Elongation 31 5.09e-01 6.05e-01 0.11300 -0.101000 0.051000 3.29e-01 6.23e-01
Tat-mediated elongation of the HIV-1 transcript 31 5.09e-01 6.05e-01 0.11300 -0.101000 0.051000 3.29e-01 6.23e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.13e-01 6.10e-01 0.19400 0.175000 0.084200 2.75e-01 5.99e-01
Iron uptake and transport 43 5.20e-01 6.16e-01 0.09990 -0.000064 0.099900 9.99e-01 2.57e-01
Loss of Nlp from mitotic centrosomes 60 5.20e-01 6.16e-01 0.09100 0.057000 0.070900 4.45e-01 3.43e-01
Loss of proteins required for interphase microtubule organization from the centrosome 60 5.20e-01 6.16e-01 0.09100 0.057000 0.070900 4.45e-01 3.43e-01
PLC beta mediated events 43 5.38e-01 6.37e-01 0.09320 0.087500 -0.032100 3.21e-01 7.16e-01
Resolution of D-Loop Structures 21 5.40e-01 6.38e-01 0.14200 -0.022600 -0.140000 8.58e-01 2.67e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 21 5.40e-01 6.38e-01 0.14200 -0.022600 -0.140000 8.58e-01 2.67e-01
SUMOylation of ubiquitinylation proteins 37 5.41e-01 6.38e-01 0.11200 0.066600 0.090000 4.84e-01 3.44e-01
G-protein activation 15 5.41e-01 6.38e-01 0.15400 0.081100 -0.131000 5.87e-01 3.78e-01
Platelet homeostasis 61 5.48e-01 6.45e-01 0.07550 0.054300 -0.052500 4.64e-01 4.78e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 5.52e-01 6.49e-01 0.15800 -0.023600 0.156000 8.74e-01 2.95e-01
Processing of Capped Intronless Pre-mRNA 25 5.53e-01 6.50e-01 0.11700 -0.098800 0.063500 3.93e-01 5.83e-01
p38MAPK events 13 5.54e-01 6.50e-01 0.18500 0.154000 0.102000 3.36e-01 5.26e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 13 5.58e-01 6.54e-01 0.16700 -0.163000 0.034300 3.08e-01 8.31e-01
TRAF3-dependent IRF activation pathway 11 5.59e-01 6.56e-01 0.19300 0.186000 0.052800 2.86e-01 7.62e-01
Dopamine Neurotransmitter Release Cycle 12 5.64e-01 6.59e-01 0.16900 0.063600 -0.157000 7.03e-01 3.48e-01
Interactions of Rev with host cellular proteins 35 5.64e-01 6.59e-01 0.10200 -0.008220 0.102000 9.33e-01 2.96e-01
Synthesis of IP3 and IP4 in the cytosol 22 5.65e-01 6.60e-01 0.12600 0.034400 -0.121000 7.80e-01 3.26e-01
Cell-cell junction organization 24 5.68e-01 6.62e-01 0.12600 0.125000 0.012600 2.87e-01 9.15e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 22 5.68e-01 6.62e-01 0.13300 -0.131000 -0.024000 2.88e-01 8.46e-01
Removal of the Flap Intermediate from the C-strand 10 5.70e-01 6.64e-01 0.19700 -0.193000 -0.036800 2.90e-01 8.41e-01
Association of TriC/CCT with target proteins during biosynthesis 32 5.72e-01 6.66e-01 0.11400 0.096100 0.062200 3.47e-01 5.43e-01
AURKA Activation by TPX2 62 5.75e-01 6.69e-01 0.08160 0.041500 0.070300 5.72e-01 3.39e-01
ADP signalling through P2Y purinoceptor 1 14 5.76e-01 6.69e-01 0.15100 0.107000 -0.106000 4.87e-01 4.94e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 27 5.78e-01 6.71e-01 0.12100 0.114000 0.040300 3.06e-01 7.17e-01
Retrograde neurotrophin signalling 10 5.79e-01 6.71e-01 0.19800 0.063700 0.187000 7.27e-01 3.06e-01
Transport of Ribonucleoproteins into the Host Nucleus 30 5.84e-01 6.76e-01 0.11600 0.063700 0.097000 5.46e-01 3.58e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 26 5.85e-01 6.77e-01 0.11800 -0.010200 -0.117000 9.28e-01 3.01e-01
TRAF6 mediated IRF7 activation 13 5.91e-01 6.83e-01 0.17400 0.148000 0.090200 3.54e-01 5.73e-01
Export of Viral Ribonucleoproteins from Nucleus 31 5.96e-01 6.88e-01 0.11200 0.057400 0.095700 5.80e-01 3.57e-01
Host Interactions with Influenza Factors 40 5.96e-01 6.88e-01 0.09810 0.085400 0.048300 3.50e-01 5.97e-01
Thromboxane signalling through TP receptor 13 6.03e-01 6.96e-01 0.15000 0.081100 -0.127000 6.13e-01 4.29e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 12 6.05e-01 6.97e-01 0.16900 -0.021900 -0.167000 8.95e-01 3.16e-01
Lysosome Vesicle Biogenesis 26 6.14e-01 7.07e-01 0.11600 0.041200 0.109000 7.16e-01 3.37e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 12 6.19e-01 7.12e-01 0.17200 0.081600 0.151000 6.25e-01 3.65e-01
DCC mediated attractive signaling 12 6.23e-01 7.15e-01 0.16700 0.161000 0.044300 3.35e-01 7.90e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 12 6.25e-01 7.16e-01 0.16500 -0.036600 -0.161000 8.26e-01 3.34e-01
Miscellaneous transport and binding events 19 6.25e-01 7.16e-01 0.13700 0.099500 0.094200 4.53e-01 4.77e-01
Visual phototransduction 47 6.26e-01 7.16e-01 0.08200 -0.007760 -0.081600 9.27e-01 3.33e-01
Regulation of FZD by ubiquitination 14 6.27e-01 7.18e-01 0.15600 0.064000 0.142000 6.79e-01 3.57e-01
Vpr-mediated nuclear import of PICs 32 6.29e-01 7.18e-01 0.09480 -0.020400 0.092600 8.42e-01 3.65e-01
G1/S-Specific Transcription 17 6.37e-01 7.27e-01 0.12700 0.123000 -0.034100 3.81e-01 8.07e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 10 6.39e-01 7.29e-01 0.18400 0.145000 0.113000 4.27e-01 5.36e-01
G0 and Early G1 17 6.42e-01 7.32e-01 0.13700 0.129000 0.044900 3.57e-01 7.49e-01
HDR through Single Strand Annealing (SSA) 30 6.47e-01 7.36e-01 0.09840 0.005740 0.098200 9.57e-01 3.52e-01
Rev-mediated nuclear export of HIV RNA 33 6.51e-01 7.40e-01 0.08880 -0.028300 0.084100 7.78e-01 4.03e-01
NS1 Mediated Effects on Host Pathways 38 6.51e-01 7.40e-01 0.09230 0.074500 0.054500 4.27e-01 5.61e-01
Nuclear Pore Complex (NPC) Disassembly 32 6.53e-01 7.41e-01 0.10100 0.073700 0.068500 4.71e-01 5.03e-01
Transport of bile salts and organic acids, metal ions and amine compounds 32 6.53e-01 7.41e-01 0.09580 -0.017400 -0.094200 8.65e-01 3.56e-01
WNT ligand biogenesis and trafficking 12 6.54e-01 7.41e-01 0.15000 -0.014200 0.150000 9.32e-01 3.70e-01
Transferrin endocytosis and recycling 20 6.56e-01 7.42e-01 0.11200 -0.103000 0.044200 4.25e-01 7.33e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 10 6.60e-01 7.46e-01 0.15500 -0.129000 0.087200 4.81e-01 6.33e-01
Thrombin signalling through proteinase activated receptors (PARs) 18 6.63e-01 7.49e-01 0.11500 0.060600 -0.098100 6.56e-01 4.71e-01
Hyaluronan metabolism 12 6.64e-01 7.50e-01 0.15200 -0.151000 -0.020000 3.66e-01 9.04e-01
NEP/NS2 Interacts with the Cellular Export Machinery 30 6.74e-01 7.60e-01 0.09640 0.025900 0.092800 8.06e-01 3.79e-01
Cytosolic tRNA aminoacylation 22 6.78e-01 7.63e-01 0.10600 -0.105000 0.011700 3.93e-01 9.24e-01
Transcription of E2F targets under negative control by DREAM complex 15 6.78e-01 7.63e-01 0.13300 0.131000 0.018800 3.78e-01 9.00e-01
Glycosphingolipid metabolism 33 6.80e-01 7.64e-01 0.09430 -0.062100 -0.070900 5.37e-01 4.81e-01
RIPK1-mediated regulated necrosis 14 6.84e-01 7.68e-01 0.13000 0.127000 -0.025100 4.09e-01 8.71e-01
Regulated Necrosis 14 6.84e-01 7.68e-01 0.13000 0.127000 -0.025100 4.09e-01 8.71e-01
mRNA Capping 22 6.84e-01 7.68e-01 0.10500 -0.104000 0.011600 3.98e-01 9.25e-01
SUMOylation of DNA replication proteins 39 6.87e-01 7.69e-01 0.08170 0.015800 0.080100 8.64e-01 3.87e-01
Sulfur amino acid metabolism 21 6.95e-01 7.77e-01 0.11500 -0.086700 -0.075100 4.92e-01 5.51e-01
Synthesis of very long-chain fatty acyl-CoAs 13 6.96e-01 7.78e-01 0.14000 0.035200 0.135000 8.26e-01 3.98e-01
Mitophagy 23 6.97e-01 7.78e-01 0.09650 -0.040400 0.087600 7.37e-01 4.67e-01
Chaperonin-mediated protein folding 65 6.97e-01 7.78e-01 0.06450 0.054400 0.034700 4.48e-01 6.29e-01
HS-GAG biosynthesis 17 6.98e-01 7.78e-01 0.11200 0.101000 -0.048600 4.72e-01 7.29e-01
HDR through Homologous Recombination (HRR) 49 6.99e-01 7.78e-01 0.07200 -0.069200 -0.019900 4.02e-01 8.10e-01
Prostacyclin signalling through prostacyclin receptor 10 7.00e-01 7.79e-01 0.16000 -0.151000 -0.054700 4.10e-01 7.65e-01
Platelet calcium homeostasis 19 7.01e-01 7.79e-01 0.10800 0.024000 -0.105000 8.56e-01 4.29e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 15 7.03e-01 7.81e-01 0.11900 -0.109000 0.045400 4.63e-01 7.61e-01
Signaling by NTRK3 (TRKC) 15 7.07e-01 7.84e-01 0.13000 0.119000 0.051200 4.24e-01 7.31e-01
Formation of HIV elongation complex in the absence of HIV Tat 33 7.07e-01 7.84e-01 0.07880 -0.071100 0.034000 4.80e-01 7.35e-01
Assembly and cell surface presentation of NMDA receptors 15 7.11e-01 7.87e-01 0.11800 -0.115000 0.028100 4.41e-01 8.51e-01
RHO GTPases Activate NADPH Oxidases 12 7.11e-01 7.87e-01 0.12800 -0.096200 0.084300 5.64e-01 6.13e-01
Plasma lipoprotein assembly 12 7.12e-01 7.87e-01 0.12800 -0.095700 0.084400 5.66e-01 6.13e-01
Cholesterol biosynthesis 20 7.12e-01 7.87e-01 0.10800 0.106000 0.021800 4.11e-01 8.66e-01
The phototransduction cascade 16 7.13e-01 7.87e-01 0.11100 -0.063500 0.090800 6.60e-01 5.30e-01
Adherens junctions interactions 14 7.14e-01 7.87e-01 0.12800 0.014000 0.127000 9.28e-01 4.12e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 21 7.17e-01 7.90e-01 0.10200 -0.002440 0.102000 9.85e-01 4.20e-01
cGMP effects 11 7.19e-01 7.91e-01 0.14800 -0.135000 -0.061200 4.39e-01 7.25e-01
CREB1 phosphorylation through the activation of Adenylate Cyclase 10 7.22e-01 7.94e-01 0.15500 0.140000 0.066100 4.44e-01 7.17e-01
Nuclear import of Rev protein 32 7.24e-01 7.96e-01 0.08350 0.015900 0.081900 8.76e-01 4.23e-01
Degradation of cysteine and homocysteine 11 7.25e-01 7.96e-01 0.14200 -0.139000 -0.030400 4.24e-01 8.61e-01
Diseases associated with glycosylation precursor biosynthesis 15 7.26e-01 7.97e-01 0.12100 -0.119000 -0.022100 4.24e-01 8.82e-01
SUMOylation of DNA methylation proteins 15 7.30e-01 8.00e-01 0.11300 0.107000 -0.034200 4.72e-01 8.18e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.36e-01 8.06e-01 0.11800 0.108000 -0.048900 5.02e-01 7.60e-01
RNA Polymerase I Transcription 48 7.39e-01 8.08e-01 0.06710 0.020100 0.064000 8.10e-01 4.43e-01
Sialic acid metabolism 26 7.40e-01 8.09e-01 0.09320 -0.050600 -0.078200 6.55e-01 4.90e-01
Receptor-type tyrosine-protein phosphatases 11 7.46e-01 8.14e-01 0.12400 0.085600 -0.089700 6.23e-01 6.07e-01
Negative epigenetic regulation of rRNA expression 44 7.53e-01 8.21e-01 0.06960 0.038300 0.058100 6.60e-01 5.05e-01
Caspase activation via extrinsic apoptotic signalling pathway 21 7.59e-01 8.26e-01 0.09930 0.083500 0.053700 5.08e-01 6.70e-01
Post-chaperonin tubulin folding pathway 15 7.59e-01 8.26e-01 0.11800 -0.079700 -0.087300 5.93e-01 5.58e-01
Sphingolipid metabolism 64 7.64e-01 8.31e-01 0.05640 0.045400 0.033400 5.31e-01 6.44e-01
SUMOylation of SUMOylation proteins 32 7.65e-01 8.31e-01 0.07400 -0.000793 0.074000 9.94e-01 4.69e-01
Pausing and recovery of Tat-mediated HIV elongation 22 7.66e-01 8.31e-01 0.08780 -0.010200 0.087200 9.34e-01 4.79e-01
Tat-mediated HIV elongation arrest and recovery 22 7.66e-01 8.31e-01 0.08780 -0.010200 0.087200 9.34e-01 4.79e-01
Formation of tubulin folding intermediates by CCT/TriC 16 7.68e-01 8.32e-01 0.09770 0.059500 -0.077500 6.80e-01 5.92e-01
Insulin receptor recycling 17 7.68e-01 8.32e-01 0.10400 -0.102000 -0.020600 4.69e-01 8.83e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 15 7.72e-01 8.36e-01 0.11400 0.078600 0.083000 5.98e-01 5.78e-01
Caspase activation via Death Receptors in the presence of ligand 13 7.75e-01 8.36e-01 0.10700 0.052400 -0.093600 7.44e-01 5.59e-01
CaM pathway 29 7.75e-01 8.36e-01 0.07120 0.054200 -0.046300 6.14e-01 6.66e-01
Calmodulin induced events 29 7.75e-01 8.36e-01 0.07120 0.054200 -0.046300 6.14e-01 6.66e-01
Biotin transport and metabolism 10 7.77e-01 8.36e-01 0.13800 0.111000 0.081200 5.42e-01 6.57e-01
p75NTR signals via NF-kB 14 7.77e-01 8.36e-01 0.11700 0.071400 0.092200 6.44e-01 5.50e-01
Leading Strand Synthesis 14 7.78e-01 8.36e-01 0.11000 -0.109000 -0.007860 4.79e-01 9.59e-01
Polymerase switching 14 7.78e-01 8.36e-01 0.11000 -0.109000 -0.007860 4.79e-01 9.59e-01
Polymerase switching on the C-strand of the telomere 14 7.78e-01 8.36e-01 0.11000 -0.109000 -0.007860 4.79e-01 9.59e-01
N-glycan antennae elongation in the medial/trans-Golgi 17 7.79e-01 8.36e-01 0.10600 0.071100 0.078200 6.12e-01 5.77e-01
RNA Polymerase I Transcription Termination 24 7.82e-01 8.38e-01 0.07740 -0.066700 0.039300 5.72e-01 7.39e-01
Plasma lipoprotein clearance 26 7.83e-01 8.38e-01 0.08060 0.014400 0.079300 8.99e-01 4.84e-01
Glycerophospholipid biosynthesis 85 7.84e-01 8.39e-01 0.04070 -0.030000 0.027600 6.33e-01 6.61e-01
Inwardly rectifying K+ channels 16 7.87e-01 8.41e-01 0.09800 0.008400 -0.097600 9.54e-01 4.99e-01
Metabolic disorders of biological oxidation enzymes 17 7.87e-01 8.41e-01 0.09590 -0.001360 0.095900 9.92e-01 4.94e-01
Neurotransmitter release cycle 26 7.96e-01 8.50e-01 0.07160 0.036000 -0.061900 7.51e-01 5.85e-01
Recruitment of NuMA to mitotic centrosomes 68 8.02e-01 8.54e-01 0.04690 0.004910 0.046700 9.44e-01 5.06e-01
Acyl chain remodelling of PC 13 8.02e-01 8.54e-01 0.10600 -0.106000 -0.003320 5.09e-01 9.83e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 11 8.02e-01 8.54e-01 0.10900 0.102000 -0.040500 5.59e-01 8.16e-01
RNA Polymerase I Promoter Clearance 47 8.04e-01 8.54e-01 0.05610 0.006240 0.055700 9.41e-01 5.09e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 11 8.05e-01 8.54e-01 0.11900 0.038100 0.113000 8.27e-01 5.18e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11 8.06e-01 8.54e-01 0.11100 0.109000 -0.018200 5.30e-01 9.17e-01
alpha-linolenic acid (ALA) metabolism 11 8.06e-01 8.54e-01 0.11100 0.109000 -0.018200 5.30e-01 9.17e-01
Synthesis of PE 10 8.06e-01 8.54e-01 0.11200 -0.086300 0.070700 6.36e-01 6.99e-01
Defects in vitamin and cofactor metabolism 18 8.07e-01 8.54e-01 0.09200 0.088100 0.026600 5.18e-01 8.45e-01
DAG and IP3 signaling 35 8.15e-01 8.63e-01 0.06610 0.056200 0.034800 5.66e-01 7.22e-01
Lysine catabolism 10 8.18e-01 8.65e-01 0.11100 -0.028900 0.107000 8.74e-01 5.58e-01
Defects in cobalamin (B12) metabolism 10 8.25e-01 8.71e-01 0.10600 0.093200 -0.051200 6.10e-01 7.79e-01
Regulation of necroptotic cell death 13 8.26e-01 8.72e-01 0.09930 0.098900 0.009130 5.37e-01 9.55e-01
TP53 Regulates Transcription of Cell Death Genes 36 8.27e-01 8.72e-01 0.05730 0.056200 -0.011000 5.60e-01 9.09e-01
Metabolism of vitamins and cofactors 128 8.28e-01 8.72e-01 0.02960 0.013100 -0.026600 7.99e-01 6.04e-01
COPI-dependent Golgi-to-ER retrograde traffic 59 8.29e-01 8.73e-01 0.04470 -0.044000 0.007730 5.59e-01 9.18e-01
Synthesis of PC 21 8.33e-01 8.77e-01 0.07650 0.007810 0.076100 9.51e-01 5.46e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 28 8.35e-01 8.77e-01 0.06800 0.023600 0.063800 8.29e-01 5.59e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 28 8.35e-01 8.77e-01 0.06800 0.023600 0.063800 8.29e-01 5.59e-01
ADP signalling through P2Y purinoceptor 12 12 8.44e-01 8.85e-01 0.09230 0.087300 -0.030000 6.01e-01 8.57e-01
mRNA decay by 3’ to 5’ exoribonuclease 13 8.46e-01 8.86e-01 0.09580 -0.091400 -0.028800 5.69e-01 8.57e-01
Purine catabolism 14 8.47e-01 8.87e-01 0.08280 -0.064700 0.051700 6.75e-01 7.38e-01
MicroRNA (miRNA) biogenesis 20 8.50e-01 8.89e-01 0.07810 0.065800 0.042000 6.10e-01 7.45e-01
G beta:gamma signalling through CDC42 12 8.51e-01 8.89e-01 0.08990 -0.084200 0.031400 6.14e-01 8.50e-01
RNA Polymerase I Promoter Escape 28 8.52e-01 8.89e-01 0.05890 -0.017500 0.056300 8.73e-01 6.06e-01
Prefoldin mediated transfer of substrate to CCT/TriC 20 8.52e-01 8.89e-01 0.07180 -0.004090 0.071700 9.75e-01 5.79e-01
Vitamin B5 (pantothenate) metabolism 13 8.59e-01 8.95e-01 0.08670 0.086400 -0.007110 5.90e-01 9.65e-01
Ca-dependent events 30 8.60e-01 8.96e-01 0.05450 0.048700 -0.024300 6.44e-01 8.18e-01
Transport of Mature mRNA Derived from an Intronless Transcript 40 8.63e-01 8.98e-01 0.05290 -0.037100 -0.037700 6.85e-01 6.80e-01
HIV elongation arrest and recovery 24 8.68e-01 9.02e-01 0.06530 0.023800 0.060800 8.40e-01 6.06e-01
Pausing and recovery of HIV elongation 24 8.68e-01 9.02e-01 0.06530 0.023800 0.060800 8.40e-01 6.06e-01
IL-6-type cytokine receptor ligand interactions 12 8.77e-01 9.09e-01 0.08240 -0.017700 0.080500 9.15e-01 6.29e-01
Synthesis of PA 22 8.77e-01 9.09e-01 0.06460 0.014900 0.062800 9.04e-01 6.10e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 41 8.77e-01 9.09e-01 0.04860 -0.023400 -0.042700 7.96e-01 6.37e-01
Hyaluronan uptake and degradation 10 8.79e-01 9.10e-01 0.09800 -0.050500 -0.084000 7.82e-01 6.46e-01
Viral Messenger RNA Synthesis 38 8.79e-01 9.10e-01 0.04780 0.005050 0.047600 9.57e-01 6.12e-01
Nicotinamide salvaging 12 8.83e-01 9.13e-01 0.07730 0.047000 -0.061400 7.78e-01 7.13e-01
Acyl chain remodelling of PE 11 8.89e-01 9.18e-01 0.08680 -0.083500 -0.023600 6.32e-01 8.92e-01
Phase I - Functionalization of compounds 55 8.94e-01 9.23e-01 0.03750 0.036800 0.007250 6.37e-01 9.26e-01
Anchoring of the basal body to the plasma membrane 85 9.00e-01 9.28e-01 0.03070 0.018900 0.024200 7.64e-01 7.00e-01
Intraflagellar transport 33 9.01e-01 9.28e-01 0.04800 -0.044000 -0.019000 6.62e-01 8.51e-01
Cilium Assembly 156 9.03e-01 9.29e-01 0.01950 -0.014700 0.012900 7.53e-01 7.82e-01
Signaling by FGFR2 IIIa TM 13 9.14e-01 9.40e-01 0.06960 -0.017200 -0.067500 9.14e-01 6.74e-01
IRE1alpha activates chaperones 42 9.16e-01 9.41e-01 0.04000 0.029200 0.027400 7.44e-01 7.59e-01
Metabolism of water-soluble vitamins and cofactors 86 9.17e-01 9.41e-01 0.02690 -0.008590 -0.025500 8.91e-01 6.83e-01
RNA Polymerase I Transcription Initiation 40 9.18e-01 9.41e-01 0.03890 0.010300 0.037500 9.10e-01 6.82e-01
NoRC negatively regulates rRNA expression 41 9.27e-01 9.50e-01 0.03720 0.020900 0.030800 8.17e-01 7.33e-01
FGFR2 mutant receptor activation 16 9.34e-01 9.55e-01 0.05250 0.052300 -0.004000 7.17e-01 9.78e-01
G beta:gamma signalling through PI3Kgamma 14 9.34e-01 9.55e-01 0.05570 0.006780 -0.055300 9.65e-01 7.20e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 18 9.34e-01 9.55e-01 0.05350 -0.043700 -0.030900 7.48e-01 8.21e-01
Protein folding 71 9.36e-01 9.56e-01 0.02650 0.014000 0.022500 8.38e-01 7.43e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 9.36e-01 9.56e-01 0.05840 -0.057400 0.010800 7.31e-01 9.48e-01
XBP1(S) activates chaperone genes 41 9.39e-01 9.58e-01 0.03360 0.015200 0.029900 8.66e-01 7.40e-01
PIWI-interacting RNA (piRNA) biogenesis 15 9.42e-01 9.60e-01 0.05140 0.051300 0.003370 7.31e-01 9.82e-01
Inositol phosphate metabolism 41 9.44e-01 9.61e-01 0.03180 0.029900 0.010800 7.40e-01 9.05e-01
Processing of Intronless Pre-mRNAs 17 9.46e-01 9.61e-01 0.04860 -0.044500 -0.019600 7.51e-01 8.89e-01
RA biosynthesis pathway 14 9.47e-01 9.61e-01 0.05040 -0.050400 0.002040 7.44e-01 9.89e-01
Neurotransmitter receptors and postsynaptic signal transmission 104 9.47e-01 9.61e-01 0.01770 0.016100 -0.007380 7.77e-01 8.97e-01
Cargo trafficking to the periciliary membrane 39 9.56e-01 9.69e-01 0.02640 -0.024500 0.009880 7.91e-01 9.15e-01
Cytosolic sulfonation of small molecules 11 9.59e-01 9.69e-01 0.04940 -0.006060 0.049000 9.72e-01 7.79e-01
Transmission across Chemical Synapses 140 9.59e-01 9.69e-01 0.01420 0.014200 0.000535 7.72e-01 9.91e-01
Glutamate Neurotransmitter Release Cycle 14 9.59e-01 9.69e-01 0.04760 0.026700 0.039400 8.63e-01 7.99e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 11 9.60e-01 9.69e-01 0.05250 0.045700 0.025700 7.93e-01 8.83e-01
Centrosome maturation 68 9.60e-01 9.69e-01 0.01950 -0.002300 0.019400 9.74e-01 7.82e-01
Recruitment of mitotic centrosome proteins and complexes 68 9.60e-01 9.69e-01 0.01950 -0.002300 0.019400 9.74e-01 7.82e-01
Fatty acyl-CoA biosynthesis 20 9.74e-01 9.82e-01 0.02890 0.028800 -0.002760 8.24e-01 9.83e-01
Presynaptic phase of homologous DNA pairing and strand exchange 30 9.80e-01 9.87e-01 0.01970 -0.014900 0.012900 8.88e-01 9.02e-01
Golgi Cisternae Pericentriolar Stack Reorganization 10 9.80e-01 9.87e-01 0.03750 0.035900 0.010800 8.44e-01 9.53e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 9.81e-01 9.87e-01 0.03440 -0.033900 -0.005550 8.46e-01 9.75e-01
Nucleobase catabolism 26 9.83e-01 9.88e-01 0.02130 -0.020800 -0.004780 8.55e-01 9.66e-01
G-protein beta:gamma signalling 20 9.86e-01 9.90e-01 0.02270 -0.021600 -0.006990 8.67e-01 9.57e-01
N-Glycan antennae elongation 11 9.87e-01 9.90e-01 0.02980 -0.018900 -0.023100 9.14e-01 8.95e-01
Homologous DNA Pairing and Strand Exchange 32 9.88e-01 9.90e-01 0.01710 -0.009680 -0.014100 9.25e-01 8.90e-01
Transport of the SLBP independent Mature mRNA 33 9.91e-01 9.92e-01 0.01290 -0.010300 0.007850 9.19e-01 9.38e-01
p75NTR recruits signalling complexes 11 9.92e-01 9.93e-01 0.02040 0.009860 -0.017800 9.55e-01 9.18e-01
Transport of the SLBP Dependant Mature mRNA 34 9.98e-01 9.98e-01 0.00552 0.005490 0.000548 9.56e-01 9.96e-01


Detailed Gene set reports


Signal Transduction





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Metabolism of RNA





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Translation





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Regulation of expression of SLITs and ROBOs





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Viral mRNA Translation





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Peptide chain elongation





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Eukaryotic Translation Elongation





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Selenocysteine synthesis





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SRP-dependent cotranslational protein targeting to membrane





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Immune System





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Formation of a pool of free 40S subunits





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Cap-dependent Translation Initiation





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Eukaryotic Translation Initiation





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Eukaryotic Translation Termination





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Selenoamino acid metabolism





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Gene expression (Transcription)





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Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.3 (2024-02-29)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] kableExtra_1.4.0 pkgload_1.3.4    GGally_2.2.1     ggplot2_3.5.0   
##  [5] reshape2_1.4.4   beeswarm_0.4.0   gplots_3.1.3.1   gtools_3.9.5    
##  [9] tibble_3.2.1     dplyr_1.1.4      echarts4r_0.4.5  mitch_1.15.2    
## 
## loaded via a namespace (and not attached):
##  [1] gtable_0.3.4       xfun_0.42          bslib_0.6.1        htmlwidgets_1.6.4 
##  [5] caTools_1.18.2     vctrs_0.6.5        tools_4.3.3        bitops_1.0-7      
##  [9] generics_0.1.3     parallel_4.3.3     fansi_1.0.6        highr_0.10        
## [13] pkgconfig_2.0.3    KernSmooth_2.23-22 RColorBrewer_1.1-3 lifecycle_1.0.4   
## [17] compiler_4.3.3     farver_2.1.1       stringr_1.5.1      munsell_0.5.0     
## [21] httpuv_1.6.14      sass_0.4.9         htmltools_0.5.7    yaml_2.3.8        
## [25] later_1.3.2        pillar_1.9.0       jquerylib_0.1.4    tidyr_1.3.1       
## [29] MASS_7.3-60.0.1    ellipsis_0.3.2     cachem_1.0.8       mime_0.12         
## [33] ggstats_0.5.1      tidyselect_1.2.1   digest_0.6.35      stringi_1.8.3     
## [37] purrr_1.0.2        labeling_0.4.3     fastmap_1.1.1      grid_4.3.3        
## [41] colorspace_2.1-0   cli_3.6.2          magrittr_2.0.3     utf8_1.2.4        
## [45] withr_3.0.0        scales_1.3.0       promises_1.2.1     rmarkdown_2.26    
## [49] gridExtra_2.3      shiny_1.8.0        evaluate_0.23      knitr_1.45        
## [53] viridisLite_0.4.2  rlang_1.1.3        Rcpp_1.0.12        xtable_1.8-4      
## [57] glue_1.7.0         xml2_1.3.6         jsonlite_1.8.8     svglite_2.1.3     
## [61] rstudioapi_0.15.0  R6_2.5.1           plyr_1.8.9         systemfonts_1.0.6

END of report