date generated: 2024-01-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
A1BG 0.0005084
A1BG-AS1 -0.0002091
A1CF 0.0012441
A2M -0.0000746
A2M-AS1 0.0046779
A2ML1 0.0016693

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1654
num_genes_in_profile 22007
duplicated_genes_present 0
num_profile_genes_in_sets 10383
num_profile_genes_not_in_sets 11624

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: c2.cp.reactome.v2023.1.Hs.symbols.gmt
Gene set metrics
Gene sets metrics
num_genesets 1654
num_genesets_excluded 365
num_genesets_included 1289

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
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set setSize pANOVA s.dist p.adjustANOVA
REACTOME SENSORY PERCEPTION 555 1.94e-06 -0.1180 0.00318
REACTOME OLFACTORY SIGNALING PATHWAY 348 3.38e-04 -0.1120 0.27700
REACTOME CD22 MEDIATED BCR REGULATION 5 7.01e-04 0.8750 0.38400
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES 30 1.57e-03 -0.3330 0.48900
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 1356 1.80e-03 0.0505 0.48900
REACTOME CREATION OF C4 AND C2 ACTIVATORS 14 1.96e-03 -0.4780 0.48900
REACTOME FORMATION OF THE CORNIFIED ENVELOPE 125 2.09e-03 -0.1590 0.48900
REACTOME RAC3 GTPASE CYCLE 85 3.08e-03 0.1860 0.55700
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 134 3.37e-03 -0.1470 0.55700
REACTOME LEISHMANIA INFECTION 156 3.39e-03 0.1360 0.55700
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 28 4.87e-03 0.3070 0.68800
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 16 5.98e-03 0.3970 0.68800
REACTOME WAX AND PLASMALOGEN BIOSYNTHESIS 5 6.56e-03 0.7020 0.68800
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION 8 6.67e-03 -0.5540 0.68800
REACTOME INITIAL TRIGGERING OF COMPLEMENT 21 6.93e-03 -0.3400 0.68800
REACTOME FERTILIZATION 26 7.20e-03 -0.3040 0.68800
REACTOME BASE EXCISION REPAIR 87 9.55e-03 0.1610 0.68800
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 66 1.02e-02 0.1830 0.68800
REACTOME DEUBIQUITINATION 260 1.04e-02 0.0923 0.68800
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE 118 1.05e-02 0.1360 0.68800
REACTOME REGULATION OF SIGNALING BY CBL 22 1.08e-02 0.3140 0.68800
REACTOME DRUG ADME 103 1.21e-02 -0.1430 0.68800
REACTOME HCMV LATE EVENTS 110 1.21e-02 0.1380 0.68800
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR4 14 1.27e-02 -0.3840 0.68800
REACTOME HDACS DEACETYLATE HISTONES 85 1.31e-02 0.1560 0.68800
REACTOME PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.40e-02 -0.4280 0.68800
REACTOME FCGR ACTIVATION 11 1.43e-02 0.4260 0.68800
REACTOME GLUCOCORTICOID BIOSYNTHESIS 10 1.52e-02 -0.4430 0.68800
REACTOME MET ACTIVATES RAP1 AND RAC1 11 1.53e-02 0.4220 0.68800
REACTOME SUMOYLATION 179 1.53e-02 0.1050 0.68800
REACTOME TRANSPORT OF SMALL MOLECULES 697 1.57e-02 -0.0537 0.68800
REACTOME MEIOTIC SYNAPSIS 73 1.61e-02 0.1630 0.68800
REACTOME RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 52 1.67e-02 0.1920 0.68800
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 39 1.73e-02 -0.2200 0.68800
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION 15 1.74e-02 -0.3550 0.68800
REACTOME SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 1.78e-02 0.3800 0.68800
REACTOME FGFR1C LIGAND BINDING AND ACTIVATION 11 1.78e-02 -0.4130 0.68800
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION 59 1.78e-02 0.1780 0.68800
REACTOME SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 68 1.81e-02 0.1660 0.68800
REACTOME FRS MEDIATED FGFR1 SIGNALING 23 1.83e-02 -0.2840 0.68800
REACTOME FRS MEDIATED FGFR4 SIGNALING 21 1.86e-02 -0.2970 0.68800
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 15 1.90e-02 0.3500 0.68800
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 1.93e-02 -0.2880 0.68800
REACTOME BASE EXCISION REPAIR AP SITE FORMATION 59 2.01e-02 0.1750 0.68800
REACTOME VISUAL PHOTOTRANSDUCTION 93 2.04e-02 -0.1390 0.68800
REACTOME CELL CYCLE 666 2.07e-02 0.0526 0.68800
REACTOME FGFR2 LIGAND BINDING AND ACTIVATION 19 2.10e-02 -0.3060 0.68800
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 112 2.12e-02 0.1260 0.68800
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 68 2.16e-02 0.1610 0.68800
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 42 2.17e-02 -0.2050 0.68800


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REACTOME SENSORY PERCEPTION 555 1.94e-06 -0.118000 0.00318
REACTOME OLFACTORY SIGNALING PATHWAY 348 3.38e-04 -0.112000 0.27700
REACTOME CD22 MEDIATED BCR REGULATION 5 7.01e-04 0.875000 0.38400
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES 30 1.57e-03 -0.333000 0.48900
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 1356 1.80e-03 0.050500 0.48900
REACTOME CREATION OF C4 AND C2 ACTIVATORS 14 1.96e-03 -0.478000 0.48900
REACTOME FORMATION OF THE CORNIFIED ENVELOPE 125 2.09e-03 -0.159000 0.48900
REACTOME RAC3 GTPASE CYCLE 85 3.08e-03 0.186000 0.55700
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 134 3.37e-03 -0.147000 0.55700
REACTOME LEISHMANIA INFECTION 156 3.39e-03 0.136000 0.55700
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 28 4.87e-03 0.307000 0.68800
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 16 5.98e-03 0.397000 0.68800
REACTOME WAX AND PLASMALOGEN BIOSYNTHESIS 5 6.56e-03 0.702000 0.68800
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION 8 6.67e-03 -0.554000 0.68800
REACTOME INITIAL TRIGGERING OF COMPLEMENT 21 6.93e-03 -0.340000 0.68800
REACTOME FERTILIZATION 26 7.20e-03 -0.304000 0.68800
REACTOME BASE EXCISION REPAIR 87 9.55e-03 0.161000 0.68800
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 66 1.02e-02 0.183000 0.68800
REACTOME DEUBIQUITINATION 260 1.04e-02 0.092300 0.68800
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE 118 1.05e-02 0.136000 0.68800
REACTOME REGULATION OF SIGNALING BY CBL 22 1.08e-02 0.314000 0.68800
REACTOME DRUG ADME 103 1.21e-02 -0.143000 0.68800
REACTOME HCMV LATE EVENTS 110 1.21e-02 0.138000 0.68800
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR4 14 1.27e-02 -0.384000 0.68800
REACTOME HDACS DEACETYLATE HISTONES 85 1.31e-02 0.156000 0.68800
REACTOME PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.40e-02 -0.428000 0.68800
REACTOME FCGR ACTIVATION 11 1.43e-02 0.426000 0.68800
REACTOME GLUCOCORTICOID BIOSYNTHESIS 10 1.52e-02 -0.443000 0.68800
REACTOME MET ACTIVATES RAP1 AND RAC1 11 1.53e-02 0.422000 0.68800
REACTOME SUMOYLATION 179 1.53e-02 0.105000 0.68800
REACTOME TRANSPORT OF SMALL MOLECULES 697 1.57e-02 -0.053700 0.68800
REACTOME MEIOTIC SYNAPSIS 73 1.61e-02 0.163000 0.68800
REACTOME RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 52 1.67e-02 0.192000 0.68800
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 39 1.73e-02 -0.220000 0.68800
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION 15 1.74e-02 -0.355000 0.68800
REACTOME SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 1.78e-02 0.380000 0.68800
REACTOME FGFR1C LIGAND BINDING AND ACTIVATION 11 1.78e-02 -0.413000 0.68800
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION 59 1.78e-02 0.178000 0.68800
REACTOME SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 68 1.81e-02 0.166000 0.68800
REACTOME FRS MEDIATED FGFR1 SIGNALING 23 1.83e-02 -0.284000 0.68800
REACTOME FRS MEDIATED FGFR4 SIGNALING 21 1.86e-02 -0.297000 0.68800
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 15 1.90e-02 0.350000 0.68800
REACTOME CYTOSOLIC TRNA AMINOACYLATION 22 1.93e-02 -0.288000 0.68800
REACTOME BASE EXCISION REPAIR AP SITE FORMATION 59 2.01e-02 0.175000 0.68800
REACTOME VISUAL PHOTOTRANSDUCTION 93 2.04e-02 -0.139000 0.68800
REACTOME CELL CYCLE 666 2.07e-02 0.052600 0.68800
REACTOME FGFR2 LIGAND BINDING AND ACTIVATION 19 2.10e-02 -0.306000 0.68800
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 112 2.12e-02 0.126000 0.68800
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 68 2.16e-02 0.161000 0.68800
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 42 2.17e-02 -0.205000 0.68800
REACTOME TRANSLATION 278 2.18e-02 -0.080000 0.68800
REACTOME RHO GTPASES ACTIVATE NADPH OXIDASES 21 2.18e-02 0.289000 0.68800
REACTOME UB SPECIFIC PROCESSING PROTEASES 187 2.30e-02 0.096400 0.70900
REACTOME PHOSPHOLIPID METABOLISM 201 2.38e-02 0.092500 0.70900
REACTOME LTC4 CYSLTR MEDIATED IL4 PRODUCTION 6 2.40e-02 0.532000 0.70900
REACTOME NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 2.42e-02 0.223000 0.70900
REACTOME POLB DEPENDENT LONG PATCH BASE EXCISION REPAIR 8 2.47e-02 0.459000 0.71000
REACTOME ASPIRIN ADME 42 2.54e-02 -0.199000 0.71400
REACTOME MEIOSIS 110 2.59e-02 0.123000 0.71400
REACTOME TRANSCRIPTIONAL REGULATION BY NPAS4 33 2.61e-02 0.224000 0.71400
REACTOME PROSTANOID LIGAND RECEPTORS 9 2.83e-02 0.422000 0.72300
REACTOME CD28 CO STIMULATION 32 2.88e-02 0.223000 0.72300
REACTOME VITAMIN C ASCORBATE METABOLISM 8 3.01e-02 0.443000 0.72300
REACTOME CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 45 3.09e-02 -0.186000 0.72300
REACTOME TYPE I HEMIDESMOSOME ASSEMBLY 11 3.24e-02 -0.373000 0.72300
REACTOME RHO GTPASE EFFECTORS 305 3.33e-02 0.070900 0.72300
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 688 3.33e-02 0.047600 0.72300
REACTOME INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA 11 3.37e-02 -0.370000 0.72300
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 679 3.37e-02 0.047800 0.72300
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 12 3.39e-02 0.354000 0.72300
REACTOME DNA REPAIR 321 3.40e-02 0.068800 0.72300
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION 12 3.42e-02 -0.353000 0.72300
REACTOME KERATINIZATION 210 3.43e-02 -0.084700 0.72300
REACTOME SPERM MOTILITY AND TAXES 9 3.45e-02 -0.407000 0.72300
REACTOME PI METABOLISM 79 3.54e-02 0.137000 0.72300
REACTOME PARASITE INFECTION 57 3.61e-02 0.160000 0.72300
REACTOME SURFACTANT METABOLISM 28 3.62e-02 -0.229000 0.72300
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 25 3.66e-02 0.241000 0.72300
REACTOME DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 30 3.69e-02 -0.220000 0.72300
REACTOME HCMV INFECTION 152 3.74e-02 0.097800 0.72300
REACTOME ION CHANNEL TRANSPORT 172 3.76e-02 -0.091900 0.72300
REACTOME REGULATION OF NPAS4 GENE EXPRESSION 13 3.78e-02 0.333000 0.72300
REACTOME INTERFERON ALPHA BETA SIGNALING 70 3.83e-02 0.143000 0.72300
REACTOME CELLULAR SENESCENCE 189 3.89e-02 0.087100 0.72300
REACTOME ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 74 3.91e-02 0.139000 0.72300
REACTOME TRANSCRIPTIONAL REGULATION BY TP53 351 3.96e-02 0.063900 0.72300
REACTOME SELENOAMINO ACID METABOLISM 108 4.01e-02 -0.114000 0.72300
REACTOME DISEASES OF MISMATCH REPAIR MMR 5 4.05e-02 0.529000 0.72300
REACTOME PTEN REGULATION 135 4.07e-02 0.102000 0.72300
REACTOME RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 4.14e-02 -0.122000 0.72300
REACTOME RAC2 GTPASE CYCLE 81 4.15e-02 0.131000 0.72300
REACTOME TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 21 4.24e-02 0.256000 0.72300
REACTOME TRAIL SIGNALING 8 4.25e-02 0.414000 0.72300
REACTOME DNA DOUBLE STRAND BREAK REPAIR 162 4.25e-02 0.092400 0.72300
REACTOME GPVI MEDIATED ACTIVATION CASCADE 35 4.27e-02 0.198000 0.72300
REACTOME NEURONAL SYSTEM 388 4.27e-02 -0.059900 0.72300
REACTOME SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 21 4.27e-02 0.255000 0.72300
REACTOME DISEASES OF PROGRAMMED CELL DEATH 96 4.33e-02 0.119000 0.72600
REACTOME SIGNALING BY TGFB FAMILY MEMBERS 119 4.44e-02 0.107000 0.73700
REACTOME MATURATION OF PROTEIN 3A 9 4.55e-02 0.385000 0.74200
REACTOME G PROTEIN BETA GAMMA SIGNALLING 30 4.56e-02 0.211000 0.74200
REACTOME POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 98 4.64e-02 0.116000 0.74700
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 22 4.71e-02 0.245000 0.75100
REACTOME PTK6 EXPRESSION 5 4.85e-02 0.509000 0.75200
REACTOME SHC MEDIATED CASCADE FGFR1 21 4.91e-02 -0.248000 0.75200
REACTOME INFECTIOUS DISEASE 910 4.95e-02 0.038400 0.75200
REACTOME DEFECTIVE F9 ACTIVATION 5 4.96e-02 0.507000 0.75200
REACTOME REGULATION OF NPAS4 MRNA TRANSLATION 9 5.11e-02 0.376000 0.75200
REACTOME RET SIGNALING 40 5.12e-02 0.178000 0.75200
REACTOME RNA POLYMERASE II TRANSCRIPTION 1336 5.13e-02 0.031800 0.75200
REACTOME PENTOSE PHOSPHATE PATHWAY 12 5.13e-02 0.325000 0.75200
REACTOME SHC MEDIATED CASCADE FGFR4 19 5.16e-02 -0.258000 0.75200
REACTOME POTENTIAL THERAPEUTICS FOR SARS 92 5.20e-02 0.117000 0.75200
REACTOME UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES 9 5.30e-02 -0.372000 0.75200
REACTOME RAB GEFS EXCHANGE GTP FOR GDP ON RABS 81 5.30e-02 0.124000 0.75200
REACTOME HOMOLOGY DIRECTED REPAIR 132 5.37e-02 0.097200 0.75200
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 113 5.44e-02 0.105000 0.75200
REACTOME THE PHOTOTRANSDUCTION CASCADE 32 5.45e-02 -0.196000 0.75200
REACTOME OPSINS 7 5.45e-02 -0.420000 0.75200
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 49 5.49e-02 0.158000 0.75200
REACTOME SENSORY PROCESSING OF SOUND 72 5.78e-02 -0.129000 0.76300
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 17 5.84e-02 -0.265000 0.76300
REACTOME RSK ACTIVATION 5 5.85e-02 0.489000 0.76300
REACTOME FRS MEDIATED FGFR2 SIGNALING 24 5.86e-02 -0.223000 0.76300
REACTOME DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B 7 5.91e-02 0.412000 0.76300
REACTOME INTERFERON SIGNALING 193 5.92e-02 0.078800 0.76300
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 5.94e-02 0.079700 0.76300
REACTOME ELASTIC FIBRE FORMATION 44 5.97e-02 0.164000 0.76300
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 14 5.99e-02 -0.290000 0.76300
REACTOME DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 17 6.12e-02 -0.262000 0.77200
REACTOME CA2 PATHWAY 62 6.16e-02 0.137000 0.77200
REACTOME MET ACTIVATES PI3K AKT SIGNALING 6 6.57e-02 0.434000 0.79800
REACTOME ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 59 6.60e-02 -0.138000 0.79800
REACTOME ACETYLCHOLINE REGULATES INSULIN SECRETION 10 6.67e-02 0.335000 0.79800
REACTOME CELL CYCLE MITOTIC 539 6.72e-02 0.046100 0.79800
REACTOME P2Y RECEPTORS 9 6.83e-02 -0.351000 0.79800
REACTOME DOPAMINE RECEPTORS 5 6.84e-02 0.471000 0.79800
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 13 6.84e-02 0.292000 0.79800
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 17 6.90e-02 0.255000 0.79800
REACTOME ANTIMICROBIAL PEPTIDES 76 6.93e-02 -0.121000 0.79800
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 55 7.02e-02 0.141000 0.79800
REACTOME EUKARYOTIC TRANSLATION ELONGATION 87 7.05e-02 -0.112000 0.79800
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 7.08e-02 0.301000 0.79800
REACTOME MEIOTIC RECOMBINATION 80 7.10e-02 0.117000 0.79800
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 105 7.15e-02 -0.102000 0.79800
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 32 7.20e-02 0.184000 0.79800
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 29 7.21e-02 0.193000 0.79800
REACTOME RNA POLYMERASE I TRANSCRIPTION 102 7.26e-02 0.103000 0.79800
REACTOME EUKARYOTIC TRANSLATION INITIATION 110 7.28e-02 -0.099000 0.79800
REACTOME FRS MEDIATED FGFR3 SIGNALING 19 7.29e-02 -0.238000 0.79800
REACTOME CELLULAR RESPONSE TO STARVATION 147 7.37e-02 -0.085500 0.79800
REACTOME SIGNAL ATTENUATION 10 7.38e-02 0.326000 0.79800
REACTOME CHROMOSOME MAINTENANCE 130 7.52e-02 0.090400 0.80300
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION 36 7.53e-02 0.171000 0.80300
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 91 7.60e-02 0.108000 0.80500
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 17 7.70e-02 0.248000 0.81000
REACTOME DNA REPLICATION INITIATION 7 7.75e-02 0.385000 0.81000
REACTOME HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS 7 7.85e-02 -0.384000 0.81300
REACTOME NEGATIVE REGULATION OF FGFR1 SIGNALING 32 7.95e-02 -0.179000 0.81300
REACTOME FGFR2 MUTANT RECEPTOR ACTIVATION 32 8.03e-02 -0.179000 0.81300
REACTOME CHYLOMICRON CLEARANCE 5 8.04e-02 0.452000 0.81300
REACTOME CELL CYCLE CHECKPOINTS 284 8.09e-02 0.060200 0.81300
REACTOME EICOSANOID LIGAND BINDING RECEPTORS 14 8.13e-02 0.269000 0.81300
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 48 8.22e-02 0.145000 0.81300
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 353 8.28e-02 -0.053700 0.81300
REACTOME ERYTHROPOIETIN ACTIVATES RAS 14 8.35e-02 0.267000 0.81300
REACTOME FGFR3 LIGAND BINDING AND ACTIVATION 12 8.37e-02 -0.288000 0.81300
REACTOME FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 83 8.41e-02 0.110000 0.81300
REACTOME PI 3K CASCADE FGFR1 21 8.43e-02 -0.218000 0.81300
REACTOME BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 42 8.50e-02 -0.154000 0.81300
REACTOME NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 12 8.50e-02 0.287000 0.81300
REACTOME PP2A MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 6 8.55e-02 -0.405000 0.81300
REACTOME ACTIVATION OF NIMA KINASES NEK9 NEK6 NEK7 7 8.57e-02 0.375000 0.81300
REACTOME NEGATIVE REGULATION OF FGFR4 SIGNALING 30 8.65e-02 -0.181000 0.81600
REACTOME RAC1 GTPASE CYCLE 172 8.92e-02 0.075100 0.83700
REACTOME PI 3K CASCADE FGFR4 19 9.04e-02 -0.224000 0.84000
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE 5 9.05e-02 -0.437000 0.84000
REACTOME MITOTIC PROPHASE 134 9.25e-02 0.084200 0.85000
REACTOME ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 11 9.31e-02 -0.292000 0.85000
REACTOME LDL REMODELING 6 9.32e-02 0.396000 0.85000
REACTOME SIGNALING BY NOTCH 234 9.41e-02 0.063500 0.85200
REACTOME DISEASES OF DNA REPAIR 51 9.47e-02 0.135000 0.85200
REACTOME PRC2 METHYLATES HISTONES AND DNA 65 9.49e-02 0.120000 0.85200
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 236 9.61e-02 -0.062900 0.85800
REACTOME ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 18 9.82e-02 -0.225000 0.87200
REACTOME ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 28 9.89e-02 -0.180000 0.87300
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 1.00e-01 0.171000 0.87600
REACTOME DEADENYLATION OF MRNA 25 1.01e-01 0.189000 0.87600
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE 277 1.02e-01 -0.057100 0.87600
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 26 1.03e-01 -0.185000 0.87600
REACTOME PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 26 1.04e-01 0.184000 0.87600
REACTOME NEPHRIN FAMILY INTERACTIONS 22 1.04e-01 0.200000 0.87600
REACTOME EPIGENETIC REGULATION OF GENE EXPRESSION 138 1.04e-01 0.080200 0.87600
REACTOME DEFECTIVE CHST3 CAUSES SEDCJD 7 1.05e-01 -0.354000 0.87600
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 90 1.05e-01 0.099000 0.87600
REACTOME HDR THROUGH MMEJ ALT NHEJ 12 1.05e-01 0.270000 0.87600
REACTOME STIMULI SENSING CHANNELS 100 1.06e-01 -0.093700 0.87600
REACTOME COMPLEMENT CASCADE 54 1.06e-01 -0.127000 0.87600
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 19 1.07e-01 0.213000 0.87800
REACTOME FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 8 1.07e-01 0.329000 0.87800
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 29 1.08e-01 0.173000 0.87800
REACTOME ROLE OF ABL IN ROBO SLIT SIGNALING 8 1.08e-01 0.328000 0.87900
REACTOME NEUROFASCIN INTERACTIONS 6 1.09e-01 -0.378000 0.88300
REACTOME SIGNALING BY FGFR 85 1.10e-01 -0.100000 0.88300
REACTOME INTRAFLAGELLAR TRANSPORT 50 1.11e-01 -0.130000 0.88400
REACTOME SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA PHE 6 1.11e-01 0.376000 0.88400
REACTOME MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.12e-01 0.255000 0.88600
REACTOME TRANSCRIPTIONAL REGULATION BY E2F6 32 1.14e-01 0.161000 0.89800
REACTOME ROS AND RNS PRODUCTION IN PHAGOCYTES 34 1.14e-01 -0.156000 0.89800
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 250 1.17e-01 0.057500 0.90100
REACTOME ACYL CHAIN REMODELLING OF PI 17 1.17e-01 -0.219000 0.90100
REACTOME RESOLUTION OF ABASIC SITES AP SITES 38 1.18e-01 0.147000 0.90100
REACTOME M PHASE 398 1.18e-01 0.045700 0.90100
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 31 1.19e-01 -0.162000 0.90100
REACTOME HATS ACETYLATE HISTONES 129 1.20e-01 0.079300 0.90100
REACTOME FASL CD95L SIGNALING 5 1.20e-01 0.402000 0.90100
REACTOME FCERI MEDIATED CA 2 MOBILIZATION 30 1.20e-01 0.164000 0.90100
REACTOME FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 85 1.21e-01 0.097300 0.90100
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 80 1.22e-01 0.100000 0.90100
REACTOME NONHOMOLOGOUS END JOINING NHEJ 64 1.22e-01 0.112000 0.90100
REACTOME METABOLISM OF NUCLEOTIDES 94 1.22e-01 0.092300 0.90100
REACTOME HEMOSTASIS 591 1.23e-01 0.037200 0.90100
REACTOME DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS 25 1.23e-01 0.178000 0.90100
REACTOME SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 104 1.23e-01 0.087400 0.90100
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 1.24e-01 0.150000 0.90100
REACTOME SIGNALING BY FGFR2 IN DISEASE 42 1.24e-01 -0.137000 0.90100
REACTOME DISEASES OF BASE EXCISION REPAIR 5 1.25e-01 0.397000 0.90100
REACTOME ADHERENS JUNCTIONS INTERACTIONS 33 1.25e-01 -0.154000 0.90100
REACTOME TRNA AMINOACYLATION 40 1.26e-01 -0.140000 0.90100
REACTOME TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 83 1.26e-01 0.097000 0.90300
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 11 1.30e-01 -0.264000 0.92000
REACTOME DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 14 1.30e-01 0.233000 0.92000
REACTOME DEFECTIVE CSF2RB CAUSES SMDP5 7 1.31e-01 -0.330000 0.92000
REACTOME PROTEIN METHYLATION 17 1.31e-01 -0.211000 0.92100
REACTOME SIGNALING BY ACTIVIN 15 1.33e-01 0.224000 0.92900
REACTOME G1 S SPECIFIC TRANSCRIPTION 28 1.34e-01 0.164000 0.92900
REACTOME RAB REGULATION OF TRAFFICKING 110 1.35e-01 0.082500 0.92900
REACTOME DNA REPLICATION PRE INITIATION 150 1.35e-01 0.070600 0.92900
REACTOME INHIBITION OF DNA RECOMBINATION AT TELOMERE 63 1.36e-01 0.109000 0.92900
REACTOME ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 62 1.36e-01 0.110000 0.92900
REACTOME VASOPRESSIN LIKE RECEPTORS 5 1.37e-01 0.384000 0.93300
REACTOME NUCLEAR ENVELOPE BREAKDOWN 52 1.38e-01 0.119000 0.93300
REACTOME AMINE LIGAND BINDING RECEPTORS 40 1.38e-01 -0.136000 0.93300
REACTOME THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 23 1.39e-01 -0.178000 0.93400
REACTOME MITOCHONDRIAL CALCIUM ION TRANSPORT 23 1.40e-01 0.178000 0.93400
REACTOME RAP1 SIGNALLING 16 1.40e-01 0.213000 0.93400
REACTOME CONDENSATION OF PROPHASE CHROMOSOMES 66 1.42e-01 0.104000 0.94200
REACTOME REGULATION OF PTEN MRNA TRANSLATION 9 1.45e-01 0.281000 0.94200
REACTOME CILIUM ASSEMBLY 190 1.46e-01 -0.061200 0.94200
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 1.46e-01 -0.233000 0.94200
REACTOME TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 36 1.47e-01 0.140000 0.94200
REACTOME HCMV EARLY EVENTS 128 1.47e-01 0.074200 0.94200
REACTOME SIGNALING BY HIPPO 19 1.48e-01 -0.192000 0.94200
REACTOME ION HOMEOSTASIS 52 1.48e-01 -0.116000 0.94200
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 1.48e-01 0.158000 0.94200
REACTOME NPAS4 REGULATES EXPRESSION OF TARGET GENES 21 1.48e-01 0.182000 0.94200
REACTOME DISEASES ASSOCIATED WITH SURFACTANT METABOLISM 9 1.48e-01 -0.278000 0.94200
REACTOME SIGNALING BY ERYTHROPOIETIN 25 1.51e-01 0.166000 0.94200
REACTOME TELOMERE C STRAND SYNTHESIS INITIATION 12 1.53e-01 0.238000 0.94200
REACTOME VITAMIN D CALCIFEROL METABOLISM 12 1.54e-01 -0.238000 0.94200
REACTOME ACYL CHAIN REMODELLING OF PG 18 1.55e-01 -0.194000 0.94200
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS 11 1.55e-01 0.247000 0.94200
REACTOME SARS COV 2 MODULATES HOST TRANSLATION MACHINERY 46 1.56e-01 -0.121000 0.94200
REACTOME RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 27 1.56e-01 0.158000 0.94200
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 111 1.58e-01 -0.077500 0.94200
REACTOME RHOV GTPASE CYCLE 36 1.59e-01 0.136000 0.94200
REACTOME SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 52 1.59e-01 -0.113000 0.94200
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 1.59e-01 0.163000 0.94200
REACTOME NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 36 1.60e-01 0.135000 0.94200
REACTOME REGULATION OF TP53 ACTIVITY 156 1.60e-01 0.065300 0.94200
REACTOME DEFECTIVE CHST14 CAUSES EDS MUSCULOCONTRACTURAL TYPE 7 1.60e-01 -0.307000 0.94200
REACTOME RESOLUTION OF D LOOP STRUCTURES 33 1.60e-01 0.141000 0.94200
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.60e-01 -0.159000 0.94200
REACTOME COLLAGEN DEGRADATION 61 1.63e-01 -0.103000 0.94200
REACTOME CDC42 GTPASE CYCLE 144 1.64e-01 0.067200 0.94200
REACTOME DNA REPLICATION 178 1.64e-01 0.060500 0.94200
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.65e-01 0.201000 0.94200
REACTOME THE ACTIVATION OF ARYLSULFATASES 8 1.65e-01 0.284000 0.94200
REACTOME UREA CYCLE 9 1.65e-01 -0.267000 0.94200
REACTOME INTRACELLULAR SIGNALING BY SECOND MESSENGERS 299 1.66e-01 0.046500 0.94200
REACTOME DNA METHYLATION 58 1.67e-01 0.105000 0.94200
REACTOME NFE2L2 REGULATING ANTI OXIDANT DETOXIFICATION ENZYMES 17 1.67e-01 -0.194000 0.94200
REACTOME RHOU GTPASE CYCLE 37 1.67e-01 0.131000 0.94200
REACTOME OTHER INTERLEUKIN SIGNALING 24 1.68e-01 -0.163000 0.94200
REACTOME APOPTOTIC EXECUTION PHASE 49 1.69e-01 0.114000 0.94200
REACTOME AMYLOID FIBER FORMATION 102 1.70e-01 0.078600 0.94200
REACTOME NEGATIVE REGULATION OF FGFR2 SIGNALING 33 1.71e-01 -0.138000 0.94200
REACTOME SIGNALING BY FGFR IN DISEASE 62 1.71e-01 -0.100000 0.94200
REACTOME REGULATION OF KIT SIGNALING 16 1.72e-01 0.197000 0.94200
REACTOME CHROMATIN MODIFYING ENZYMES 252 1.72e-01 0.050000 0.94200
REACTOME SUMOYLATION OF IMMUNE RESPONSE PROTEINS 10 1.73e-01 -0.249000 0.94200
REACTOME TRANSCRIPTIONAL REGULATION BY SMALL RNAS 100 1.73e-01 0.078800 0.94200
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 106 1.73e-01 0.076600 0.94200
REACTOME SYNTHESIS OF EPOXY EET AND DIHYDROXYEICOSATRIENOIC ACIDS DHET 8 1.73e-01 -0.278000 0.94200
REACTOME INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 45 1.74e-01 0.117000 0.94200
REACTOME DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 76 1.74e-01 0.090200 0.94200
REACTOME RHOQ GTPASE CYCLE 57 1.75e-01 0.104000 0.94200
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 14 1.75e-01 0.209000 0.94200
REACTOME RESPIRATORY ELECTRON TRANSPORT 90 1.77e-01 -0.082400 0.94200
REACTOME OVARIAN TUMOR DOMAIN PROTEASES 36 1.78e-01 0.130000 0.94200
REACTOME POTASSIUM CHANNELS 102 1.78e-01 -0.077100 0.94200
REACTOME ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 41 1.79e-01 -0.121000 0.94200
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 16 1.79e-01 -0.194000 0.94200
REACTOME GENE SILENCING BY RNA 133 1.80e-01 0.067300 0.94200
REACTOME SIGNALING BY BMP 27 1.80e-01 0.149000 0.94200
REACTOME SHC MEDIATED CASCADE FGFR3 17 1.81e-01 -0.188000 0.94200
REACTOME TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 20 1.81e-01 -0.173000 0.94200
REACTOME NUCLEOTIDE SALVAGE 21 1.81e-01 0.169000 0.94200
REACTOME NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 25 1.81e-01 -0.155000 0.94200
REACTOME SIGNALING BY FGFR4 40 1.81e-01 -0.122000 0.94200
REACTOME SIGNALING BY NUCLEAR RECEPTORS 283 1.82e-01 0.046100 0.94200
REACTOME TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION 5 1.82e-01 0.345000 0.94200
REACTOME SIGNALING BY FGFR2 72 1.82e-01 -0.090900 0.94200
REACTOME REGULATION OF NPAS4 GENE TRANSCRIPTION 5 1.83e-01 0.344000 0.94200
REACTOME PREGNENOLONE BIOSYNTHESIS 12 1.83e-01 0.222000 0.94200
REACTOME RAF ACTIVATION 33 1.86e-01 -0.133000 0.94200
REACTOME PHASE 0 RAPID DEPOLARISATION 31 1.87e-01 -0.137000 0.94200
REACTOME POST TRANSCRIPTIONAL SILENCING BY SMALL RNAS 7 1.88e-01 0.288000 0.94200
REACTOME SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 1.88e-01 -0.196000 0.94200
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 101 1.88e-01 -0.075800 0.94200
REACTOME CD163 MEDIATING AN ANTI INFLAMMATORY RESPONSE 9 1.88e-01 0.253000 0.94200
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 291 1.89e-01 -0.044800 0.94200
REACTOME ADRENOCEPTORS 9 1.89e-01 -0.253000 0.94200
REACTOME ABACAVIR ADME 9 1.89e-01 -0.253000 0.94200
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 15 1.90e-01 0.195000 0.94200
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 22 1.91e-01 -0.161000 0.94200
REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 1.92e-01 -0.161000 0.94200
REACTOME ASSEMBLY OF THE HIV VIRION 16 1.92e-01 0.188000 0.94200
REACTOME SIGNALING BY FGFR1 49 1.92e-01 -0.108000 0.94200
REACTOME TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 29 1.93e-01 0.140000 0.94200
REACTOME G2 M DNA DAMAGE CHECKPOINT 90 1.94e-01 0.079200 0.94200
REACTOME PROCESSING OF SMDT1 16 1.95e-01 0.187000 0.94200
REACTOME MISMATCH REPAIR 15 1.95e-01 0.193000 0.94200
REACTOME COLLAGEN CHAIN TRIMERIZATION 42 1.96e-01 -0.115000 0.94200
REACTOME INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 37 1.97e-01 0.123000 0.94200
REACTOME RHOD GTPASE CYCLE 49 1.97e-01 0.107000 0.94200
REACTOME NUCLEAR PORE COMPLEX NPC DISASSEMBLY 36 1.97e-01 0.124000 0.94200
REACTOME DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 77 1.98e-01 0.084800 0.94200
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 15 1.99e-01 0.192000 0.94200
REACTOME INTERLEUKIN 35 SIGNALLING 12 1.99e-01 0.214000 0.94200
REACTOME MITOTIC SPINDLE CHECKPOINT 109 2.00e-01 0.071000 0.94200
REACTOME TRANSCRIPTIONAL REGULATION BY VENTX 41 2.00e-01 0.116000 0.94200
REACTOME FGFR3B LIGAND BINDING AND ACTIVATION 7 2.01e-01 -0.279000 0.94200
REACTOME SIGNALING BY ALK IN CANCER 53 2.02e-01 0.101000 0.94200
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1 229 2.02e-01 0.048900 0.94200
REACTOME INTERLEUKIN 23 SIGNALING 9 2.03e-01 0.245000 0.94200
REACTOME TELOMERE MAINTENANCE 106 2.03e-01 0.071500 0.94200
REACTOME RHO GTPASES ACTIVATE PKNS 86 2.03e-01 0.079400 0.94200
REACTOME GERM LAYER FORMATION AT GASTRULATION 17 2.03e-01 0.178000 0.94200
REACTOME TIGHT JUNCTION INTERACTIONS 29 2.04e-01 0.136000 0.94200
REACTOME LATE ENDOSOMAL MICROAUTOPHAGY 33 2.05e-01 0.128000 0.94200
REACTOME GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 30 2.06e-01 -0.133000 0.94200
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 29 2.07e-01 -0.135000 0.94200
REACTOME PHOSPHORYLATION OF EMI1 6 2.07e-01 0.297000 0.94200
REACTOME SIGNALING BY NTRKS 132 2.07e-01 0.063600 0.94200
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 8 2.07e-01 0.257000 0.94200
REACTOME DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1 9 2.08e-01 0.242000 0.94200
REACTOME CARDIAC CONDUCTION 125 2.08e-01 -0.065200 0.94200
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 2.09e-01 -0.098000 0.94200
REACTOME NONSENSE MEDIATED DECAY NMD 107 2.10e-01 -0.070200 0.94200
REACTOME B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 84 2.11e-01 0.079000 0.94200
REACTOME AFLATOXIN ACTIVATION AND DETOXIFICATION 19 2.11e-01 0.166000 0.94200
REACTOME PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 2.11e-01 0.158000 0.94200
REACTOME PI 3K CASCADE FGFR2 22 2.11e-01 -0.154000 0.94200
REACTOME SIGNALING BY CSF1 M CSF IN MYELOID CELLS 30 2.12e-01 0.132000 0.94200
REACTOME CELLULAR RESPONSE TO HEAT STRESS 99 2.12e-01 -0.072500 0.94200
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 123 2.13e-01 0.065000 0.94200
REACTOME ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 59 2.13e-01 0.093700 0.94200
REACTOME METABOLISM OF LIPIDS 709 2.13e-01 0.027400 0.94200
REACTOME HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 66 2.15e-01 0.088200 0.94200
REACTOME ORGANIC ANION TRANSPORT 5 2.16e-01 -0.320000 0.94200
REACTOME SERINE BIOSYNTHESIS 9 2.16e-01 0.238000 0.94200
REACTOME MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 17 2.16e-01 0.173000 0.94200
REACTOME DNA STRAND ELONGATION 31 2.17e-01 0.128000 0.94200
REACTOME INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 2.18e-01 0.135000 0.94200
REACTOME MITOTIC G2 G2 M PHASES 194 2.19e-01 -0.051200 0.94200
REACTOME RHO GTPASE CYCLE 423 2.19e-01 0.034800 0.94200
REACTOME VLDL ASSEMBLY 5 2.19e-01 0.317000 0.94200
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 24 2.21e-01 0.144000 0.94200
REACTOME REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 11 2.22e-01 0.213000 0.94200
REACTOME CELLULAR HEXOSE TRANSPORT 21 2.22e-01 -0.154000 0.94200
REACTOME RUNX3 REGULATES YAP1 MEDIATED TRANSCRIPTION 8 2.24e-01 -0.248000 0.94200
REACTOME NEGATIVE REGULATION OF FGFR3 SIGNALING 28 2.25e-01 -0.133000 0.94200
REACTOME TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 14 2.26e-01 0.187000 0.94200
REACTOME RHOA GTPASE CYCLE 142 2.27e-01 0.058800 0.94200
REACTOME GLUCURONIDATION 23 2.27e-01 -0.146000 0.94200
REACTOME GLYCOGEN STORAGE DISEASES 15 2.27e-01 -0.180000 0.94200
REACTOME PYROPTOSIS 27 2.27e-01 0.134000 0.94200
REACTOME STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 2.27e-01 -0.221000 0.94200
REACTOME REGULATION OF TP53 EXPRESSION AND DEGRADATION 37 2.29e-01 0.114000 0.94200
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 46 2.29e-01 0.103000 0.94200
REACTOME FREE FATTY ACID RECEPTORS 5 2.30e-01 0.310000 0.94200
REACTOME DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 61 2.30e-01 -0.088800 0.94200
REACTOME ATTACHMENT AND ENTRY 16 2.31e-01 -0.173000 0.94200
REACTOME FORMATION OF TC NER PRE INCISION COMPLEX 51 2.31e-01 -0.097000 0.94200
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 49 2.32e-01 0.098700 0.94200
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 15 2.32e-01 -0.178000 0.94200
REACTOME RHOF GTPASE CYCLE 40 2.33e-01 0.109000 0.94200
REACTOME NECTIN NECL TRANS HETERODIMERIZATION 7 2.34e-01 -0.259000 0.94200
REACTOME NRCAM INTERACTIONS 6 2.35e-01 -0.280000 0.94200
REACTOME FCGR3A MEDIATED IL10 SYNTHESIS 36 2.35e-01 0.114000 0.94200
REACTOME SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 15 2.35e-01 -0.177000 0.94200
REACTOME CYTOPROTECTION BY HMOX1 59 2.35e-01 -0.089300 0.94200
REACTOME FGFRL1 MODULATION OF FGFR1 SIGNALING 13 2.37e-01 -0.189000 0.94200
REACTOME GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 42 2.37e-01 0.105000 0.94200
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 99 2.38e-01 -0.068600 0.94200
REACTOME DISEASES OF METABOLISM 237 2.38e-01 -0.044500 0.94200
REACTOME TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 43 2.40e-01 0.103000 0.94200
REACTOME RHO GTPASES ACTIVATE IQGAPS 31 2.41e-01 -0.122000 0.94200
REACTOME DISEASES OF CARBOHYDRATE METABOLISM 31 2.41e-01 -0.122000 0.94200
REACTOME HS GAG DEGRADATION 19 2.43e-01 -0.155000 0.94200
REACTOME COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 21 2.43e-01 -0.147000 0.94200
REACTOME SEMAPHORIN INTERACTIONS 61 2.44e-01 0.086300 0.94200
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 10 2.44e-01 0.213000 0.94200
REACTOME RHOJ GTPASE CYCLE 51 2.44e-01 0.094300 0.94200
REACTOME RIBAVIRIN ADME 11 2.45e-01 -0.203000 0.94200
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 83 2.45e-01 -0.073800 0.94200
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 24 2.45e-01 0.137000 0.94200
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX IN CANCER 8 2.46e-01 0.237000 0.94200
REACTOME SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 2.46e-01 0.158000 0.94200
REACTOME REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 2.46e-01 -0.052900 0.94200
REACTOME NEGATIVE REGULATION OF MAPK PATHWAY 41 2.47e-01 -0.104000 0.94200
REACTOME PYRIMIDINE SALVAGE 10 2.47e-01 0.211000 0.94200
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH CDK5 6 2.47e-01 0.273000 0.94200
REACTOME SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 2.48e-01 -0.167000 0.94200
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 121 2.48e-01 0.060800 0.94200
REACTOME GABA RECEPTOR ACTIVATION 57 2.49e-01 0.088300 0.94200
REACTOME NEUREXINS AND NEUROLIGINS 51 2.50e-01 -0.093200 0.94200
REACTOME COSTIMULATION BY THE CD28 FAMILY 64 2.52e-01 0.082900 0.94200
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS 6 2.52e-01 0.270000 0.94200
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 40 2.52e-01 -0.105000 0.94200
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 13 2.53e-01 0.183000 0.94200
REACTOME TRAF6 MEDIATED NF KB ACTIVATION 24 2.53e-01 0.135000 0.94200
REACTOME NEUTROPHIL DEGRANULATION 460 2.54e-01 0.031000 0.94200
REACTOME JOSEPHIN DOMAIN DUBS 11 2.54e-01 -0.199000 0.94200
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 26 2.55e-01 -0.129000 0.94200
REACTOME SIGNALLING TO ERKS 34 2.55e-01 0.113000 0.94200
REACTOME REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 81 2.57e-01 -0.072800 0.94200
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 255 2.57e-01 -0.041200 0.94200
REACTOME RNA POLYMERASE I TRANSCRIPTION INITIATION 45 2.57e-01 0.097600 0.94200
REACTOME RELAXIN RECEPTORS 8 2.57e-01 -0.231000 0.94200
REACTOME SUMO IS TRANSFERRED FROM E1 TO E2 UBE2I UBC9 7 2.58e-01 -0.247000 0.94200
REACTOME IRAK1 RECRUITS IKK COMPLEX 12 2.58e-01 -0.189000 0.94200
REACTOME SELECTIVE AUTOPHAGY 79 2.59e-01 -0.073500 0.94200
REACTOME SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 43 2.59e-01 -0.099500 0.94200
REACTOME G2 M CHECKPOINTS 162 2.59e-01 0.051400 0.94200
REACTOME ESR MEDIATED SIGNALING 210 2.59e-01 0.045200 0.94200
REACTOME FGFR2B LIGAND BINDING AND ACTIVATION 10 2.60e-01 -0.206000 0.94200
REACTOME AMINO ACID CONJUGATION 9 2.60e-01 -0.217000 0.94200
REACTOME RHOB GTPASE CYCLE 67 2.60e-01 0.079500 0.94200
REACTOME CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 12 2.60e-01 -0.188000 0.94200
REACTOME TERMINAL PATHWAY OF COMPLEMENT 8 2.61e-01 0.230000 0.94200
REACTOME LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7 2.61e-01 0.245000 0.94200
REACTOME ROBO RECEPTORS BIND AKAP5 9 2.62e-01 0.216000 0.94200
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 56 2.62e-01 0.086700 0.94200
REACTOME ESTROGEN DEPENDENT GENE EXPRESSION 140 2.62e-01 0.054900 0.94200
REACTOME ION TRANSPORT BY P TYPE ATPASES 51 2.63e-01 -0.090600 0.94200
REACTOME ESTROGEN BIOSYNTHESIS 6 2.63e-01 -0.264000 0.94200
REACTOME L1CAM INTERACTIONS 112 2.64e-01 -0.061200 0.94200
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS 30 2.64e-01 -0.118000 0.94200
REACTOME MULTIFUNCTIONAL ANION EXCHANGERS 9 2.65e-01 -0.215000 0.94200
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 25 2.66e-01 0.128000 0.94600
REACTOME NETRIN MEDIATED REPULSION SIGNALS 8 2.68e-01 -0.226000 0.94900
REACTOME PROLONGED ERK ACTIVATION EVENTS 14 2.69e-01 0.171000 0.94900
REACTOME EGFR TRANSACTIVATION BY GASTRIN 9 2.70e-01 -0.212000 0.94900
REACTOME MAPK3 ERK1 ACTIVATION 10 2.71e-01 0.201000 0.94900
REACTOME GASTRULATION 49 2.71e-01 0.090800 0.94900
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 14 2.72e-01 0.170000 0.94900
REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 2.73e-01 0.191000 0.94900
REACTOME SIGNALING BY FGFR1 IN DISEASE 38 2.74e-01 -0.103000 0.94900
REACTOME NUCLEOTIDE EXCISION REPAIR 107 2.75e-01 -0.061100 0.94900
REACTOME MUCOPOLYSACCHARIDOSES 10 2.75e-01 -0.200000 0.94900
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 24 2.75e-01 -0.129000 0.94900
REACTOME MAP2K AND MAPK ACTIVATION 38 2.75e-01 -0.102000 0.94900
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH PI3K 7 2.77e-01 0.237000 0.94900
REACTOME EPITHELIAL MESENCHYMAL TRANSITION EMT DURING GASTRULATION 7 2.78e-01 0.237000 0.94900
REACTOME INTERLEUKIN 10 SIGNALING 43 2.78e-01 0.095700 0.94900
REACTOME ASPARTATE AND ASPARAGINE METABOLISM 11 2.78e-01 0.189000 0.94900
REACTOME CHL1 INTERACTIONS 9 2.78e-01 0.209000 0.94900
REACTOME PURINE CATABOLISM 17 2.79e-01 0.152000 0.94900
REACTOME INFLUENZA INFECTION 149 2.79e-01 -0.051400 0.94900
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 36 2.79e-01 0.104000 0.94900
REACTOME FORMATION OF LATERAL PLATE MESODERM 5 2.80e-01 0.279000 0.94900
REACTOME VLDL CLEARANCE 6 2.81e-01 0.254000 0.94900
REACTOME METALLOPROTEASE DUBS 36 2.81e-01 0.104000 0.94900
REACTOME BIOSYNTHESIS OF MARESINS 8 2.82e-01 -0.220000 0.94900
REACTOME NEDDYLATION 235 2.82e-01 0.040700 0.94900
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 418 2.83e-01 0.030600 0.94900
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 2.83e-01 0.122000 0.94900
REACTOME TYSND1 CLEAVES PEROXISOMAL PROTEINS 7 2.84e-01 0.234000 0.94900
REACTOME MOLECULES ASSOCIATED WITH ELASTIC FIBRES 37 2.84e-01 0.102000 0.94900
REACTOME PI 3K CASCADE FGFR3 17 2.84e-01 -0.150000 0.94900
REACTOME NR1H2 AND NR1H3 MEDIATED SIGNALING 46 2.86e-01 0.091000 0.95200
REACTOME MITOPHAGY 28 2.89e-01 -0.116000 0.95800
REACTOME SYNTHESIS OF UDP N ACETYL GLUCOSAMINE 7 2.89e-01 -0.231000 0.95800
REACTOME MITOTIC METAPHASE AND ANAPHASE 228 2.90e-01 0.040700 0.95800
REACTOME SULFIDE OXIDATION TO SULFATE 6 2.90e-01 -0.249000 0.95800
REACTOME MITOCHONDRIAL TRANSLATION 93 2.91e-01 -0.063400 0.95800
REACTOME FATTY ACIDS BOUND TO GPR40 FFAR1 REGULATE INSULIN SECRETION 8 2.91e-01 0.215000 0.95800
REACTOME INTEGRIN SIGNALING 27 2.92e-01 0.117000 0.95800
REACTOME PRE NOTCH PROCESSING IN GOLGI 18 2.93e-01 0.143000 0.95800
REACTOME SCAVENGING BY CLASS A RECEPTORS 19 2.93e-01 -0.139000 0.95800
REACTOME SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 52 2.93e-01 -0.084200 0.95800
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY 24 2.94e-01 0.124000 0.95900
REACTOME TRANSCRIPTIONAL REGULATION BY MECP2 60 2.96e-01 0.077900 0.96100
REACTOME BETA CATENIN PHOSPHORYLATION CASCADE 16 2.97e-01 -0.151000 0.96100
REACTOME MET ACTIVATES PTPN11 5 2.97e-01 0.269000 0.96100
REACTOME HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS 9 2.97e-01 -0.201000 0.96100
REACTOME LYSOSOME VESICLE BIOGENESIS 33 2.98e-01 0.105000 0.96100
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 31 2.99e-01 0.108000 0.96100
REACTOME PROCESSING OF INTRONLESS PRE MRNAS 19 2.99e-01 0.138000 0.96100
REACTOME G ALPHA S SIGNALLING EVENTS 155 3.00e-01 -0.048200 0.96200
REACTOME PI3K AKT ACTIVATION 9 3.00e-01 0.199000 0.96200
REACTOME GAP JUNCTION ASSEMBLY 36 3.02e-01 -0.099400 0.96300
REACTOME MRNA EDITING 10 3.03e-01 0.188000 0.96300
REACTOME DERMATAN SULFATE BIOSYNTHESIS 10 3.03e-01 -0.188000 0.96300
REACTOME TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 13 3.03e-01 -0.165000 0.96300
REACTOME PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 77 3.04e-01 -0.067700 0.96400
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION 23 3.05e-01 0.124000 0.96400
REACTOME PROTEIN FOLDING 96 3.05e-01 0.060500 0.96400
REACTOME SIGNALING BY NOTCH1 T 7 9 NOTCH1 M1580 K2555 TRANSLOCATION MUTANT 7 3.06e-01 -0.223000 0.96400
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 9 3.08e-01 -0.196000 0.96500
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT 15 3.08e-01 -0.152000 0.96500
REACTOME ADAPTIVE IMMUNE SYSTEM 729 3.09e-01 0.022100 0.96500
REACTOME REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 7 3.09e-01 0.222000 0.96500
REACTOME SARS COV INFECTIONS 392 3.10e-01 0.029900 0.96500
REACTOME RHO GTPASES ACTIVATE WASPS AND WAVES 34 3.10e-01 0.101000 0.96500
REACTOME TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 36 3.11e-01 0.097500 0.96500
REACTOME LAGGING STRAND SYNTHESIS 19 3.12e-01 0.134000 0.96500
REACTOME HDL REMODELING 10 3.12e-01 0.185000 0.96500
REACTOME BIOLOGICAL OXIDATIONS 210 3.12e-01 -0.040500 0.96500
REACTOME PROTON COUPLED MONOCARBOXYLATE TRANSPORT 6 3.13e-01 0.238000 0.96500
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 98 3.15e-01 -0.058700 0.96500
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 3.16e-01 -0.075500 0.96500
REACTOME RHO GTPASES ACTIVATE CIT 19 3.16e-01 0.133000 0.96500
REACTOME RNA POLYMERASE I PROMOTER ESCAPE 83 3.16e-01 0.063700 0.96500
REACTOME SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 14 3.17e-01 -0.155000 0.96500
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS 5 3.17e-01 0.258000 0.96500
REACTOME NUCLEAR IMPORT OF REV PROTEIN 34 3.17e-01 0.099100 0.96500
REACTOME SENSORY PERCEPTION OF TASTE 47 3.18e-01 -0.084300 0.96500
REACTOME METABOLISM OF AMINE DERIVED HORMONES 17 3.20e-01 -0.139000 0.97200
REACTOME ERKS ARE INACTIVATED 13 3.21e-01 -0.159000 0.97300
REACTOME SUMOYLATION OF RNA BINDING PROTEINS 47 3.22e-01 0.083500 0.97300
REACTOME PHENYLALANINE METABOLISM 6 3.23e-01 0.233000 0.97300
REACTOME PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 3.24e-01 0.131000 0.97300
REACTOME HORMONE LIGAND BINDING RECEPTORS 12 3.24e-01 -0.165000 0.97300
REACTOME CLEC7A INFLAMMASOME PATHWAY 6 3.24e-01 0.232000 0.97300
REACTOME FIBRONECTIN MATRIX FORMATION 6 3.26e-01 0.232000 0.97300
REACTOME IRS MEDIATED SIGNALLING 47 3.28e-01 -0.082500 0.97300
REACTOME COPI MEDIATED ANTEROGRADE TRANSPORT 101 3.28e-01 -0.056300 0.97300
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 51 3.31e-01 0.078700 0.97300
REACTOME TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 3.31e-01 -0.132000 0.97300
REACTOME SIGNALING BY INTERLEUKINS 444 3.32e-01 0.026800 0.97300
REACTOME DNA DAMAGE RECOGNITION IN GG NER 36 3.34e-01 -0.093000 0.97300
REACTOME HIV ELONGATION ARREST AND RECOVERY 33 3.34e-01 -0.097100 0.97300
REACTOME HEDGEHOG OFF STATE 111 3.35e-01 -0.053000 0.97300
REACTOME ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 11 3.35e-01 0.168000 0.97300
REACTOME GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 81 3.35e-01 -0.061900 0.97300
REACTOME AGGREPHAGY 42 3.36e-01 -0.085800 0.97300
REACTOME SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 31 3.36e-01 -0.099800 0.97300
REACTOME BETA OXIDATION OF BUTANOYL COA TO ACETYL COA 5 3.36e-01 0.248000 0.97300
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY DVL INTERACTING PROTEINS 5 3.37e-01 -0.248000 0.97300
REACTOME G PROTEIN ACTIVATION 24 3.38e-01 0.113000 0.97300
REACTOME REGULATED PROTEOLYSIS OF P75NTR 11 3.38e-01 0.167000 0.97300
REACTOME DIGESTION 17 3.40e-01 -0.134000 0.97300
REACTOME RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS 5 3.40e-01 0.246000 0.97300
REACTOME SEROTONIN RECEPTORS 11 3.41e-01 -0.166000 0.97300
REACTOME REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 3.41e-01 0.100000 0.97300
REACTOME ACTIVATION OF RAC1 12 3.42e-01 0.158000 0.97300
REACTOME RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 16 3.43e-01 -0.137000 0.97300
REACTOME DIGESTION AND ABSORPTION 22 3.43e-01 -0.117000 0.97300
REACTOME SIGNALING BY INSULIN RECEPTOR 80 3.43e-01 -0.061300 0.97300
REACTOME DNA DOUBLE STRAND BREAK RESPONSE 74 3.45e-01 0.063500 0.97300
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 91 3.46e-01 -0.057100 0.97300
REACTOME NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 193 3.46e-01 -0.039300 0.97300
REACTOME DEFECTIVE RIPK1 MEDIATED REGULATED NECROSIS 7 3.47e-01 -0.205000 0.97300
REACTOME NEGATIVE REGULATION OF MET ACTIVITY 20 3.47e-01 0.121000 0.97300
REACTOME ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 23 3.48e-01 0.113000 0.97300
REACTOME DEATH RECEPTOR SIGNALING 143 3.48e-01 0.045400 0.97300
REACTOME INACTIVATION OF CSF3 G CSF SIGNALING 25 3.49e-01 -0.108000 0.97300
REACTOME IRON UPTAKE AND TRANSPORT 56 3.49e-01 -0.072300 0.97300
REACTOME APEX1 INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY 7 3.49e-01 0.204000 0.97300
REACTOME RESOLUTION OF SISTER CHROMATID COHESION 120 3.50e-01 0.049400 0.97300
REACTOME PHENYLALANINE AND TYROSINE METABOLISM 11 3.50e-01 0.163000 0.97300
REACTOME ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 3.51e-01 -0.131000 0.97300
REACTOME N GLYCAN ANTENNAE ELONGATION 15 3.51e-01 0.139000 0.97300
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 32 3.52e-01 0.095200 0.97300
REACTOME GLYCEROPHOSPHOLIPID CATABOLISM 7 3.53e-01 -0.203000 0.97300
REACTOME INSULIN RECEPTOR RECYCLING 29 3.53e-01 -0.099700 0.97300
REACTOME TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS 12 3.54e-01 0.155000 0.97300
REACTOME PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 21 3.54e-01 0.117000 0.97300
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 23 3.55e-01 -0.112000 0.97300
REACTOME TRIGLYCERIDE BIOSYNTHESIS 12 3.55e-01 0.154000 0.97300
REACTOME G ALPHA Q SIGNALLING EVENTS 206 3.55e-01 0.037400 0.97300
REACTOME SIGNALING BY FGFR3 39 3.56e-01 -0.085400 0.97300
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 13 3.56e-01 -0.148000 0.97300
REACTOME HYALURONAN UPTAKE AND DEGRADATION 12 3.57e-01 0.154000 0.97300
REACTOME DEFECTIVE B4GALT1 CAUSES B4GALT1 CDG CDG 2D 8 3.57e-01 0.188000 0.97300
REACTOME DEFECTIVE C1GALT1C1 CAUSES TNPS 16 3.57e-01 -0.133000 0.97300
REACTOME OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 8 3.57e-01 -0.188000 0.97300
REACTOME INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 18 3.58e-01 0.125000 0.97300
REACTOME TOXICITY OF BOTULINUM TOXIN TYPE D BOTD 5 3.59e-01 0.237000 0.97300
REACTOME ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA 5 3.60e-01 0.237000 0.97300
REACTOME TRNA PROCESSING 105 3.60e-01 0.051700 0.97300
REACTOME REGULATION OF BACH1 ACTIVITY 11 3.62e-01 -0.159000 0.97300
REACTOME ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 87 3.62e-01 -0.056500 0.97300
REACTOME SUMOYLATION OF DNA METHYLATION PROTEINS 16 3.62e-01 0.132000 0.97300
REACTOME HDMS DEMETHYLATE HISTONES 40 3.63e-01 0.083200 0.97300
REACTOME DAG AND IP3 SIGNALING 40 3.64e-01 -0.083000 0.97300
REACTOME TRNA PROCESSING IN THE NUCLEUS 58 3.64e-01 0.068900 0.97300
REACTOME MAPK6 MAPK4 SIGNALING 91 3.64e-01 0.055000 0.97300
REACTOME COMMON PATHWAY OF FIBRIN CLOT FORMATION 21 3.64e-01 -0.114000 0.97300
REACTOME THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 159 3.65e-01 -0.041600 0.97300
REACTOME BLOOD GROUP SYSTEMS BIOSYNTHESIS 21 3.67e-01 0.114000 0.97300
REACTOME INSULIN PROCESSING 24 3.67e-01 0.106000 0.97300
REACTOME CD28 DEPENDENT VAV1 PATHWAY 11 3.68e-01 0.157000 0.97300
REACTOME CALNEXIN CALRETICULIN CYCLE 26 3.69e-01 0.102000 0.97300
REACTOME O LINKED GLYCOSYLATION OF MUCINS 61 3.69e-01 0.066500 0.97300
REACTOME MEMBRANE TRAFFICKING 603 3.70e-01 0.021400 0.97300
REACTOME ER QUALITY CONTROL COMPARTMENT ERQC 21 3.70e-01 0.113000 0.97300
REACTOME PHASE I FUNCTIONALIZATION OF COMPOUNDS 101 3.70e-01 -0.051600 0.97300
REACTOME G0 AND EARLY G1 27 3.71e-01 0.099500 0.97300
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE 11 3.71e-01 -0.156000 0.97300
REACTOME SYNTHESIS OF LIPOXINS LX 6 3.71e-01 0.211000 0.97300
REACTOME METAL ION SLC TRANSPORTERS 23 3.71e-01 0.108000 0.97300
REACTOME TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 29 3.72e-01 0.095700 0.97300
REACTOME CREB3 FACTORS ACTIVATE GENES 8 3.73e-01 -0.182000 0.97300
REACTOME MITOTIC G1 PHASE AND G1 S TRANSITION 145 3.73e-01 0.042900 0.97300
REACTOME SIGNALING BY LEPTIN 11 3.73e-01 -0.155000 0.97300
REACTOME PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 93 3.74e-01 0.053300 0.97300
REACTOME INDUCTION OF CELL CELL FUSION 12 3.76e-01 0.148000 0.97300
REACTOME PIWI INTERACTING RNA PIRNA BIOGENESIS 29 3.76e-01 -0.095000 0.97300
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 129 3.77e-01 0.045000 0.97300
REACTOME G BETA GAMMA SIGNALLING THROUGH CDC42 19 3.77e-01 0.117000 0.97300
REACTOME RORA ACTIVATES GENE EXPRESSION 17 3.77e-01 -0.124000 0.97300
REACTOME GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 34 3.78e-01 0.087300 0.97300
REACTOME NEGATIVE REGULATION OF NOTCH4 SIGNALING 53 3.79e-01 -0.069900 0.97300
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE 8 3.79e-01 -0.179000 0.97300
REACTOME PINK1 PRKN MEDIATED MITOPHAGY 22 3.80e-01 -0.108000 0.97300
REACTOME KINESINS 59 3.81e-01 -0.066000 0.97300
REACTOME MITOTIC TELOPHASE CYTOKINESIS 11 3.81e-01 0.153000 0.97300
REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 21 3.83e-01 -0.110000 0.97300
REACTOME ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 3.84e-01 -0.063400 0.97300
REACTOME ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.84e-01 0.145000 0.97300
REACTOME GLUTATHIONE SYNTHESIS AND RECYCLING 12 3.84e-01 0.145000 0.97300
REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 3.85e-01 -0.139000 0.97300
REACTOME RUNX3 REGULATES BCL2L11 BIM TRANSCRIPTION 5 3.85e-01 0.224000 0.97300
REACTOME DISEASES OF GLYCOSYLATION 137 3.86e-01 -0.042900 0.97300
REACTOME RAF INDEPENDENT MAPK1 3 ACTIVATION 22 3.86e-01 0.107000 0.97300
REACTOME SUMO IS PROTEOLYTICALLY PROCESSED 6 3.87e-01 -0.204000 0.97300
REACTOME TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 52 3.88e-01 -0.069300 0.97300
REACTOME PHASE II CONJUGATION OF COMPOUNDS 102 3.88e-01 -0.049500 0.97300
REACTOME FGFR1 MUTANT RECEPTOR ACTIVATION 31 3.88e-01 -0.089600 0.97300
REACTOME BIOSYNTHESIS OF MARESIN LIKE SPMS 6 3.88e-01 -0.203000 0.97300
REACTOME METABOLISM OF CARBOHYDRATES 279 3.89e-01 0.030000 0.97300
REACTOME NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY 6 3.90e-01 0.203000 0.97300
REACTOME FC EPSILON RECEPTOR FCERI SIGNALING 127 3.91e-01 0.044100 0.97300
REACTOME PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1 9 3.91e-01 0.165000 0.97300
REACTOME RUNX2 REGULATES BONE DEVELOPMENT 29 3.91e-01 0.091900 0.97300
REACTOME COHESIN LOADING ONTO CHROMATIN 8 3.93e-01 0.175000 0.97300
REACTOME MRNA EDITING C TO U CONVERSION 8 3.93e-01 0.174000 0.97300
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 37 3.93e-01 0.081100 0.97300
REACTOME BETA CATENIN INDEPENDENT WNT SIGNALING 145 3.95e-01 0.040900 0.97300
REACTOME RAS SIGNALING DOWNSTREAM OF NF1 LOSS OF FUNCTION VARIANTS 7 3.95e-01 -0.186000 0.97300
REACTOME CELLULAR RESPONSE TO CHEMICAL STRESS 188 3.96e-01 -0.035900 0.97300
REACTOME GLYCOLYSIS 70 3.97e-01 0.058600 0.97300
REACTOME TRANSLESION SYNTHESIS BY POLH 19 3.97e-01 -0.112000 0.97300
REACTOME TRANSPORT OF ORGANIC ANIONS 10 3.98e-01 -0.154000 0.97300
REACTOME CLEC7A DECTIN 1 SIGNALING 97 4.00e-01 -0.049400 0.97300
REACTOME ACTIVATION OF C3 AND C5 6 4.01e-01 0.198000 0.97300
REACTOME RMTS METHYLATE HISTONE ARGININES 72 4.01e-01 0.057300 0.97300
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 18 4.01e-01 -0.114000 0.97300
REACTOME DOWNREGULATION OF ERBB2 SIGNALING 29 4.01e-01 -0.090100 0.97300
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 20 4.02e-01 -0.108000 0.97300
REACTOME PRE NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 6 4.03e-01 -0.197000 0.97300
REACTOME FLT3 SIGNALING 38 4.03e-01 0.078400 0.97300
REACTOME FCERI MEDIATED MAPK ACTIVATION 32 4.03e-01 0.085400 0.97300
REACTOME O LINKED GLYCOSYLATION 109 4.04e-01 0.046300 0.97300
REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV 1 INFECTION 5 4.04e-01 -0.215000 0.97300
REACTOME MATURATION OF SARS COV 2 SPIKE PROTEIN 35 4.06e-01 0.081100 0.97300
REACTOME TLR3 MEDIATED TICAM1 DEPENDENT PROGRAMMED CELL DEATH 6 4.06e-01 0.196000 0.97300
REACTOME RHOBTB GTPASE CYCLE 34 4.08e-01 -0.082100 0.97300
REACTOME MRNA SPLICING MINOR PATHWAY 49 4.08e-01 -0.068300 0.97300
REACTOME ECM PROTEOGLYCANS 73 4.09e-01 -0.055900 0.97300
REACTOME REPRODUCTION 136 4.09e-01 0.041000 0.97300
REACTOME COLLAGEN FORMATION 88 4.09e-01 -0.050900 0.97300
REACTOME THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 77 4.10e-01 -0.054400 0.97300
REACTOME FGFR1B LIGAND BINDING AND ACTIVATION 6 4.10e-01 -0.194000 0.97300
REACTOME CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 4.10e-01 -0.150000 0.97300
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 4.10e-01 0.080400 0.97300
REACTOME RAS PROCESSING 22 4.11e-01 -0.101000 0.97300
REACTOME METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 122 4.11e-01 0.043100 0.97300
REACTOME INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 20 4.11e-01 -0.106000 0.97300
REACTOME DRUG MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY 5 4.12e-01 -0.212000 0.97300
REACTOME CELL JUNCTION ORGANIZATION 89 4.13e-01 -0.050300 0.97300
REACTOME SIGNALING BY FGFR2 IIIA TM 19 4.13e-01 -0.109000 0.97300
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 53 4.13e-01 -0.065000 0.97300
REACTOME S PHASE 159 4.14e-01 0.037600 0.97300
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE GIP 12 4.15e-01 0.136000 0.97300
REACTOME IRS ACTIVATION 5 4.16e-01 0.210000 0.97300
REACTOME BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 4.18e-01 -0.097700 0.97300
REACTOME REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 4.18e-01 -0.051100 0.97300
REACTOME STAT5 ACTIVATION 7 4.18e-01 -0.177000 0.97300
REACTOME BUDDING AND MATURATION OF HIV VIRION 28 4.18e-01 0.088400 0.97300
REACTOME MHC CLASS II ANTIGEN PRESENTATION 121 4.18e-01 -0.042600 0.97300
REACTOME GAB1 SIGNALOSOME 17 4.19e-01 0.113000 0.97300
REACTOME P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 6 4.19e-01 0.190000 0.97300
REACTOME SIGNALING BY GPCR 673 4.20e-01 -0.018200 0.97300
REACTOME VXPX CARGO TARGETING TO CILIUM 20 4.20e-01 0.104000 0.97300
REACTOME GLUTAMATE AND GLUTAMINE METABOLISM 13 4.21e-01 -0.129000 0.97300
REACTOME SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 16 4.23e-01 0.116000 0.97700
REACTOME RHO GTPASES ACTIVATE FORMINS 136 4.23e-01 0.039700 0.97700
REACTOME INTERLEUKIN 1 SIGNALING 110 4.25e-01 0.044000 0.97900
REACTOME TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 4.26e-01 0.080000 0.97900
REACTOME SIALIC ACID METABOLISM 33 4.27e-01 0.079900 0.97900
REACTOME SIGNALING BY LRP5 MUTANTS 6 4.28e-01 -0.187000 0.97900
REACTOME SIGNALING BY RETINOIC ACID 41 4.30e-01 0.071300 0.97900
REACTOME ABC TRANSPORTER DISORDERS 76 4.30e-01 -0.052300 0.97900
REACTOME INTERLEUKIN 20 FAMILY SIGNALING 25 4.30e-01 -0.091100 0.97900
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 19 4.32e-01 0.104000 0.97900
REACTOME ATORVASTATIN ADME 9 4.33e-01 -0.151000 0.97900
REACTOME CROSS PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS PHAGOSOMES 6 4.33e-01 -0.185000 0.97900
REACTOME RHOBTB3 ATPASE CYCLE 8 4.33e-01 -0.160000 0.97900
REACTOME COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 38 4.34e-01 0.073300 0.97900
REACTOME SODIUM COUPLED PHOSPHATE COTRANSPORTERS 5 4.34e-01 -0.202000 0.97900
REACTOME SIGNALING BY VEGF 102 4.35e-01 0.044800 0.97900
REACTOME TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 76 4.35e-01 -0.051800 0.97900
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 91 4.36e-01 0.047300 0.97900
REACTOME SIGNAL AMPLIFICATION 33 4.36e-01 0.078400 0.97900
REACTOME OAS ANTIVIRAL RESPONSE 8 4.36e-01 0.159000 0.97900
REACTOME RNA POLYMERASE II TRANSCRIBES SNRNA GENES 77 4.36e-01 -0.051300 0.97900
REACTOME MOLYBDENUM COFACTOR BIOSYNTHESIS 6 4.37e-01 0.183000 0.97900
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 22 4.37e-01 0.095700 0.97900
REACTOME KERATAN SULFATE DEGRADATION 13 4.39e-01 0.124000 0.98100
REACTOME TRP CHANNELS 27 4.39e-01 -0.086000 0.98100
REACTOME DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 19 4.41e-01 -0.102000 0.98300
REACTOME METABOLISM OF INGESTED SEMET SEC MESEC INTO H2SE 7 4.43e-01 -0.167000 0.98700
REACTOME NGF STIMULATED TRANSCRIPTION 38 4.44e-01 0.071700 0.98800
REACTOME MITOCHONDRIAL BIOGENESIS 87 4.46e-01 -0.047300 0.99000
REACTOME MIRO GTPASE CYCLE 8 4.47e-01 0.155000 0.99200
REACTOME DEFECTIVE GALNT3 CAUSES HFTC 16 4.48e-01 -0.110000 0.99200
REACTOME INTERLEUKIN 7 SIGNALING 31 4.52e-01 0.078100 0.99400
REACTOME RUNX3 REGULATES P14 ARF 10 4.52e-01 -0.137000 0.99400
REACTOME TERMINATION OF TRANSLESION DNA SYNTHESIS 32 4.53e-01 0.076600 0.99400
REACTOME MTOR SIGNALLING 40 4.54e-01 0.068400 0.99400
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 15 4.56e-01 0.111000 0.99400
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS 45 4.56e-01 -0.064200 0.99400
REACTOME PTK6 REGULATES CELL CYCLE 6 4.57e-01 -0.175000 0.99400
REACTOME CIPROFLOXACIN ADME 5 4.57e-01 -0.192000 0.99400
REACTOME PROCESSING AND ACTIVATION OF SUMO 10 4.57e-01 -0.136000 0.99400
REACTOME SUMOYLATION OF TRANSCRIPTION COFACTORS 43 4.58e-01 0.065500 0.99400
REACTOME SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 60 4.58e-01 0.055400 0.99400
REACTOME INTERLEUKIN 12 FAMILY SIGNALING 53 4.58e-01 0.058900 0.99400
REACTOME NUCLEAR EVENTS MEDIATED BY NFE2L2 77 4.59e-01 -0.048800 0.99400
REACTOME INTERLEUKIN 1 FAMILY SIGNALING 146 4.60e-01 0.035500 0.99400
REACTOME RND1 GTPASE CYCLE 41 4.61e-01 0.066600 0.99400
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 4.62e-01 -0.080300 0.99400
REACTOME RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION 8 4.62e-01 0.150000 0.99400
REACTOME GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION 7 4.63e-01 -0.160000 0.99400
REACTOME NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 100 4.64e-01 0.042400 0.99400
REACTOME SYNTHESIS OF PG 8 4.65e-01 -0.149000 0.99400
REACTOME TOLL LIKE RECEPTOR 9 TLR9 CASCADE 100 4.67e-01 0.042100 0.99400
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 38 4.69e-01 -0.067900 0.99400
REACTOME KSRP KHSRP BINDS AND DESTABILIZES MRNA 17 4.69e-01 0.101000 0.99400
REACTOME CHOLESTEROL BIOSYNTHESIS 25 4.70e-01 0.083400 0.99400
REACTOME DISORDERS OF TRANSMEMBRANE TRANSPORTERS 170 4.73e-01 -0.031900 0.99400
REACTOME C TYPE LECTIN RECEPTORS CLRS 136 4.73e-01 -0.035600 0.99400
REACTOME MET RECEPTOR ACTIVATION 6 4.73e-01 0.169000 0.99400
REACTOME SIGNALING BY WNT 318 4.73e-01 0.023400 0.99400
REACTOME CHOLINE CATABOLISM 6 4.75e-01 -0.169000 0.99400
REACTOME GLUCONEOGENESIS 33 4.76e-01 0.071600 0.99400
REACTOME NS1 MEDIATED EFFECTS ON HOST PATHWAYS 41 4.77e-01 0.064200 0.99400
REACTOME COENZYME A BIOSYNTHESIS 8 4.77e-01 0.145000 0.99400
REACTOME NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 22 4.77e-01 -0.087500 0.99400
REACTOME UNWINDING OF DNA 12 4.78e-01 0.118000 0.99400
REACTOME HYALURONAN METABOLISM 17 4.78e-01 0.099300 0.99400
REACTOME METABOLISM OF RNA 675 4.78e-01 0.016000 0.99400
REACTOME TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 4.79e-01 0.118000 0.99400
REACTOME MET ACTIVATES RAS SIGNALING 11 4.79e-01 0.123000 0.99400
REACTOME COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 52 4.80e-01 -0.056700 0.99400
REACTOME MATURATION OF SARS COV 2 NUCLEOPROTEIN 15 4.80e-01 -0.105000 0.99400
REACTOME FLT3 SIGNALING IN DISEASE 28 4.81e-01 -0.076900 0.99400
REACTOME SIGNALING BY CSF3 G CSF 30 4.83e-01 -0.074000 0.99400
REACTOME DNA DAMAGE REVERSAL 8 4.84e-01 0.143000 0.99400
REACTOME MISCELLANEOUS SUBSTRATES 12 4.84e-01 0.117000 0.99400
REACTOME HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 43 4.85e-01 0.061600 0.99400
REACTOME INTERLEUKIN 2 FAMILY SIGNALING 40 4.85e-01 0.063900 0.99400
REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS 23 4.85e-01 0.084200 0.99400
REACTOME SIGNALING BY BRAF AND RAF1 FUSIONS 63 4.85e-01 0.050800 0.99400
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 53 4.87e-01 -0.055200 0.99400
REACTOME PHYSIOLOGICAL FACTORS 14 4.88e-01 0.107000 0.99400
REACTOME PURINE SALVAGE 12 4.88e-01 0.116000 0.99400
REACTOME HIV LIFE CYCLE 145 4.88e-01 0.033300 0.99400
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 30 4.89e-01 -0.073000 0.99400
REACTOME SYNTHESIS OF PIPS AT THE ER MEMBRANE 5 4.91e-01 0.178000 0.99400
REACTOME INOSITOL PHOSPHATE METABOLISM 45 4.92e-01 0.059200 0.99400
REACTOME HIV TRANSCRIPTION ELONGATION 42 4.92e-01 -0.061300 0.99400
REACTOME ALK MUTANTS BIND TKIS 12 4.92e-01 0.114000 0.99400
REACTOME OTHER SEMAPHORIN INTERACTIONS 18 4.93e-01 0.093400 0.99400
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX 8 4.93e-01 0.140000 0.99400
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 14 4.93e-01 0.106000 0.99400
REACTOME RND3 GTPASE CYCLE 41 4.93e-01 -0.061900 0.99400
REACTOME GAP JUNCTION TRAFFICKING AND REGULATION 49 4.93e-01 -0.056500 0.99400
REACTOME SYNTHESIS OF DIPHTHAMIDE EEF2 8 4.94e-01 0.140000 0.99400
REACTOME SIGNALING BY NTRK3 TRKC 17 4.95e-01 -0.095600 0.99400
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 296 4.96e-01 0.023000 0.99400
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 4.97e-01 0.051200 0.99400
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 21 4.98e-01 0.085500 0.99400
REACTOME SIGNALING BY PDGF 57 5.00e-01 -0.051700 0.99400
REACTOME TOLL LIKE RECEPTOR CASCADES 158 5.00e-01 0.031100 0.99400
REACTOME CGMP EFFECTS 16 5.01e-01 -0.097100 0.99400
REACTOME SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 74 5.03e-01 0.045100 0.99400
REACTOME FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.03e-01 0.122000 0.99400
REACTOME REGULATION OF TLR BY ENDOGENOUS LIGAND 21 5.04e-01 -0.084200 0.99400
REACTOME SIGNALING BY NOTCH2 32 5.04e-01 -0.068200 0.99400
REACTOME SARS COV 1 INFECTION 136 5.05e-01 0.033100 0.99400
REACTOME SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 17 5.06e-01 -0.093200 0.99400
REACTOME PROLACTIN RECEPTOR SIGNALING 15 5.06e-01 -0.099200 0.99400
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 5.06e-01 0.062300 0.99400
REACTOME SPHINGOLIPID METABOLISM 84 5.07e-01 -0.041900 0.99400
REACTOME THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 5.07e-01 0.073700 0.99400
REACTOME RELEASE OF HH NP FROM THE SECRETING CELL 8 5.09e-01 0.135000 0.99400
REACTOME ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA 9 5.09e-01 -0.127000 0.99400
REACTOME DEGRADATION OF DVL 56 5.09e-01 -0.051000 0.99400
REACTOME DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 5.10e-01 -0.041800 0.99400
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY 23 5.11e-01 -0.079200 0.99400
REACTOME GAP JUNCTION DEGRADATION 12 5.11e-01 0.110000 0.99400
REACTOME SMOOTH MUSCLE CONTRACTION 43 5.13e-01 0.057700 0.99400
REACTOME MET ACTIVATES PTK2 SIGNALING 30 5.13e-01 -0.069100 0.99400
REACTOME TNFR1 INDUCED PROAPOPTOTIC SIGNALING 23 5.13e-01 0.078800 0.99400
REACTOME SYNDECAN INTERACTIONS 26 5.13e-01 -0.074100 0.99400
REACTOME G ALPHA I SIGNALLING EVENTS 304 5.14e-01 -0.021700 0.99400
REACTOME APOPTOTIC FACTOR MEDIATED RESPONSE 19 5.14e-01 0.086400 0.99400
REACTOME CARGO CONCENTRATION IN THE ER 32 5.15e-01 0.066600 0.99400
REACTOME DEFECTIVE CHSY1 CAUSES TPBS 7 5.15e-01 -0.142000 0.99400
REACTOME UBIQUINOL BIOSYNTHESIS 8 5.15e-01 -0.133000 0.99400
REACTOME METALLOTHIONEINS BIND METALS 11 5.15e-01 -0.113000 0.99400
REACTOME LINOLEIC ACID LA METABOLISM 7 5.15e-01 0.142000 0.99400
REACTOME TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION 12 5.15e-01 0.108000 0.99400
REACTOME DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15 8 5.16e-01 0.133000 0.99400
REACTOME RECYCLING OF EIF2 GDP 7 5.16e-01 -0.142000 0.99400
REACTOME CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 63 5.17e-01 -0.047200 0.99400
REACTOME PYRIMIDINE CATABOLISM 12 5.21e-01 -0.107000 0.99400
REACTOME CA DEPENDENT EVENTS 36 5.21e-01 -0.061900 0.99400
REACTOME TNFR2 NON CANONICAL NF KB PATHWAY 96 5.21e-01 -0.037900 0.99400
REACTOME APOPTOSIS 173 5.21e-01 0.028300 0.99400
REACTOME INTERLEUKIN RECEPTOR SHC SIGNALING 24 5.22e-01 0.075500 0.99400
REACTOME SEPARATION OF SISTER CHROMATIDS 184 5.22e-01 0.027300 0.99400
REACTOME ESTABLISHMENT OF SISTER CHROMATID COHESION 9 5.23e-01 0.123000 0.99400
REACTOME PD 1 SIGNALING 21 5.23e-01 -0.080400 0.99400
REACTOME VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 42 5.24e-01 0.056800 0.99400
REACTOME G2 PHASE 5 5.25e-01 -0.164000 0.99400
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA PLCG 7 5.25e-01 0.139000 0.99400
REACTOME CLASS A 1 RHODOPSIN LIKE RECEPTORS 312 5.26e-01 0.020900 0.99400
REACTOME ONCOGENIC MAPK SIGNALING 79 5.27e-01 0.041200 0.99400
REACTOME INWARDLY RECTIFYING K CHANNELS 35 5.28e-01 0.061600 0.99400
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS 9 5.29e-01 0.121000 0.99400
REACTOME DISEASES OF MITOTIC CELL CYCLE 37 5.29e-01 -0.059700 0.99400
REACTOME DEFECTIVE EXT2 CAUSES EXOSTOSES 2 12 5.31e-01 -0.105000 0.99400
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 26 5.32e-01 0.070900 0.99400
REACTOME DEPOLYMERISATION OF THE NUCLEAR LAMINA 14 5.32e-01 0.096500 0.99400
REACTOME RNA POLYMERASE III CHAIN ELONGATION 18 5.32e-01 -0.085000 0.99400
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 24 5.32e-01 0.073600 0.99400
REACTOME PHOSPHORYLATION OF THE APC C 20 5.33e-01 0.080600 0.99400
REACTOME CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 24 5.33e-01 0.073500 0.99400
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING 6 5.33e-01 0.147000 0.99400
REACTOME RIPK1 MEDIATED REGULATED NECROSIS 30 5.34e-01 -0.065600 0.99400
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 30 5.35e-01 -0.065500 0.99400
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 15 5.36e-01 0.092300 0.99400
REACTOME PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 7 5.37e-01 0.135000 0.99400
REACTOME ONCOGENE INDUCED SENESCENCE 35 5.38e-01 0.060200 0.99400
REACTOME MRNA CAPPING 28 5.38e-01 -0.067200 0.99400
REACTOME CROSSLINKING OF COLLAGEN FIBRILS 16 5.39e-01 0.088800 0.99400
REACTOME SARS COV 1 MODULATES HOST TRANSLATION MACHINERY 33 5.39e-01 -0.061800 0.99400
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 43 5.39e-01 0.054100 0.99400
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE 5 5.40e-01 0.158000 0.99400
REACTOME MET INTERACTS WITH TNS PROTEINS 5 5.41e-01 0.158000 0.99400
REACTOME MUSCARINIC ACETYLCHOLINE RECEPTORS 5 5.41e-01 -0.158000 0.99400
REACTOME SARS COV 2 TARGETS PDZ PROTEINS IN CELL CELL JUNCTION 5 5.42e-01 0.157000 0.99400
REACTOME PROTEIN UBIQUITINATION 76 5.43e-01 0.040400 0.99400
REACTOME CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 19 5.43e-01 -0.080700 0.99400
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 16 5.44e-01 0.087600 0.99400
REACTOME AQUAPORIN MEDIATED TRANSPORT 51 5.48e-01 0.048700 0.99400
REACTOME PROGRAMMED CELL DEATH 204 5.48e-01 0.024400 0.99400
REACTOME REGULATION BY C FLIP 11 5.49e-01 0.104000 0.99400
REACTOME REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 54 5.50e-01 -0.047100 0.99400
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX2 117 5.50e-01 0.032000 0.99400
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 27 5.52e-01 -0.066000 0.99400
REACTOME INTERLEUKIN 18 SIGNALING 8 5.53e-01 0.121000 0.99400
REACTOME TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 26 5.53e-01 0.067200 0.99400
REACTOME GP1B IX V ACTIVATION SIGNALLING 11 5.54e-01 0.103000 0.99400
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 44 5.54e-01 0.051600 0.99400
REACTOME HIV INFECTION 223 5.54e-01 0.023000 0.99400
REACTOME CALCINEURIN ACTIVATES NFAT 9 5.56e-01 0.113000 0.99400
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 20 5.56e-01 0.076000 0.99400
REACTOME SIGNALING BY NOTCH1 69 5.57e-01 0.040900 0.99400
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 16 5.57e-01 -0.084700 0.99400
REACTOME NEUROTRANSMITTER CLEARANCE 9 5.57e-01 -0.113000 0.99400
REACTOME RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 5.57e-01 0.055700 0.99400
REACTOME SUMO IS CONJUGATED TO E1 UBA2 SAE1 5 5.57e-01 -0.151000 0.99400
REACTOME METABOLISM OF STEROIDS 150 5.58e-01 -0.027700 0.99400
REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK 111 5.58e-01 0.032200 0.99400
REACTOME CS DS DEGRADATION 12 5.61e-01 0.096800 0.99400
REACTOME ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 41 5.62e-01 0.052300 0.99400
REACTOME HEME DEGRADATION 15 5.63e-01 -0.086300 0.99400
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 11 5.64e-01 -0.100000 0.99400
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS 9 5.64e-01 0.111000 0.99400
REACTOME RETINOID CYCLE DISEASE EVENTS 11 5.64e-01 -0.100000 0.99400
REACTOME RECYCLING OF BILE ACIDS AND SALTS 18 5.65e-01 -0.078400 0.99400
REACTOME ALPHA DEFENSINS 6 5.65e-01 -0.136000 0.99400
REACTOME MELANIN BIOSYNTHESIS 5 5.65e-01 0.148000 0.99400
REACTOME SARS COV 2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS 12 5.66e-01 0.095700 0.99400
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS 34 5.67e-01 0.056800 0.99400
REACTOME PROTEIN LOCALIZATION 153 5.68e-01 -0.026700 0.99400
REACTOME EFFECTS OF PIP2 HYDROLYSIS 26 5.69e-01 0.064600 0.99400
REACTOME HDR THROUGH SINGLE STRAND ANNEALING SSA 37 5.69e-01 0.054100 0.99400
REACTOME CYCLIN D ASSOCIATED EVENTS IN G1 46 5.69e-01 -0.048500 0.99400
REACTOME MITOTIC PROMETAPHASE 194 5.70e-01 0.023700 0.99400
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 19 5.71e-01 0.075100 0.99400
REACTOME POLO LIKE KINASE MEDIATED EVENTS 16 5.71e-01 0.081800 0.99400
REACTOME AURKA ACTIVATION BY TPX2 69 5.71e-01 -0.039400 0.99400
REACTOME BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 17 5.72e-01 0.079200 0.99400
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 16 5.73e-01 0.081300 0.99400
REACTOME TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 12 5.75e-01 0.093500 0.99400
REACTOME PCP CE PATHWAY 91 5.76e-01 -0.033900 0.99400
REACTOME ATTACHMENT OF GPI ANCHOR TO UPAR 7 5.76e-01 0.122000 0.99400
REACTOME INACTIVATION OF CDC42 AND RAC1 8 5.77e-01 -0.114000 0.99400
REACTOME EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 33 5.78e-01 0.056000 0.99400
REACTOME SIGNALING BY NODAL 20 5.78e-01 0.071900 0.99400
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY 14 5.79e-01 -0.085600 0.99400
REACTOME TRANSPORT OF FATTY ACIDS 8 5.79e-01 -0.113000 0.99400
REACTOME COPII MEDIATED VESICLE TRANSPORT 66 5.79e-01 0.039500 0.99400
REACTOME DISINHIBITION OF SNARE FORMATION 5 5.79e-01 0.143000 0.99400
REACTOME TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 30 5.80e-01 -0.058400 0.99400
REACTOME THYROXINE BIOSYNTHESIS 10 5.80e-01 -0.101000 0.99400
REACTOME REPRESSION OF WNT TARGET GENES 14 5.80e-01 0.085400 0.99400
REACTOME FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 29 5.80e-01 -0.059300 0.99400
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 20 5.81e-01 0.071300 0.99400
REACTOME INTERLEUKIN 12 SIGNALING 43 5.82e-01 0.048500 0.99400
REACTOME DEFECTIVE CHST6 CAUSES MCDC1 8 5.82e-01 0.112000 0.99400
REACTOME ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION 10 5.83e-01 0.100000 0.99400
REACTOME TIE2 SIGNALING 18 5.83e-01 0.074800 0.99400
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 5.83e-01 0.059900 0.99400
REACTOME BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA 6 5.83e-01 0.129000 0.99400
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 23 5.84e-01 0.065900 0.99400
REACTOME SYNTHESIS OF 12 EICOSATETRAENOIC ACID DERIVATIVES 7 5.85e-01 -0.119000 0.99400
REACTOME INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 198 5.86e-01 -0.022500 0.99400
REACTOME AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 5.86e-01 -0.042900 0.99400
REACTOME REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 11 5.86e-01 0.094800 0.99400
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING 5 5.87e-01 -0.140000 0.99400
REACTOME SIGNALING BY FLT3 FUSION PROTEINS 19 5.87e-01 -0.072000 0.99400
REACTOME SODIUM CALCIUM EXCHANGERS 11 5.88e-01 -0.094300 0.99400
REACTOME NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 19 5.88e-01 0.071700 0.99400
REACTOME BASIGIN INTERACTIONS 24 5.89e-01 0.063700 0.99400
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 5.89e-01 -0.086600 0.99400
REACTOME SIGNALING BY PDGFR IN DISEASE 20 5.89e-01 0.069800 0.99400
REACTOME ARACHIDONIC ACID METABOLISM 57 5.91e-01 -0.041200 0.99400
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 29 5.92e-01 -0.057600 0.99400
REACTOME WNT LIGAND BIOGENESIS AND TRAFFICKING 25 5.92e-01 -0.061900 0.99400
REACTOME SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 8 5.93e-01 0.109000 0.99400
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 53 5.94e-01 -0.042300 0.99400
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 54 5.95e-01 0.041800 0.99400
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 11 5.96e-01 0.092200 0.99400
REACTOME REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 5.97e-01 -0.092200 0.99400
REACTOME REGULATION OF BETA CELL DEVELOPMENT 41 5.98e-01 0.047600 0.99400
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 81 5.98e-01 0.033900 0.99400
REACTOME PREVENTION OF PHAGOSOMAL LYSOSOMAL FUSION 9 5.98e-01 0.101000 0.99400
REACTOME METABOLISM OF PORPHYRINS 26 5.99e-01 -0.059600 0.99400
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 50 5.99e-01 -0.043000 0.99400
REACTOME ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 5 6.00e-01 0.136000 0.99400
REACTOME NADE MODULATES DEATH SIGNALLING 5 6.00e-01 0.135000 0.99400
REACTOME AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 9 6.00e-01 0.101000 0.99400
REACTOME CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 25 6.01e-01 0.060500 0.99400
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 6.01e-01 -0.044600 0.99400
REACTOME TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION 41 6.01e-01 0.047200 0.99400
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 5 6.02e-01 0.135000 0.99400
REACTOME REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 9 6.02e-01 0.100000 0.99400
REACTOME METABOLISM OF FOLATE AND PTERINES 17 6.02e-01 0.073000 0.99400
REACTOME BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA 5 6.03e-01 0.134000 0.99400
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS 6 6.03e-01 0.123000 0.99400
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 11 6.03e-01 0.090500 0.99400
REACTOME SUPPRESSION OF APOPTOSIS 7 6.04e-01 -0.113000 0.99400
REACTOME XENOBIOTICS 22 6.04e-01 -0.063900 0.99400
REACTOME TRANSPORT AND SYNTHESIS OF PAPS 6 6.04e-01 0.122000 0.99400
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 15 6.04e-01 -0.077300 0.99400
REACTOME CREB PHOSPHORYLATION 6 6.05e-01 0.122000 0.99400
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS 16 6.05e-01 0.074700 0.99400
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 15 6.05e-01 -0.077100 0.99400
REACTOME INTERLEUKIN 36 PATHWAY 7 6.05e-01 -0.113000 0.99400
REACTOME CELLULAR RESPONSE TO HYPOXIA 74 6.06e-01 -0.034700 0.99400
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 6.06e-01 -0.094300 0.99400
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 6.06e-01 -0.056400 0.99400
REACTOME PLATELET CALCIUM HOMEOSTASIS 27 6.08e-01 0.057000 0.99400
REACTOME INTERFERON GAMMA SIGNALING 88 6.08e-01 0.031600 0.99400
REACTOME RECYCLING PATHWAY OF L1 43 6.10e-01 -0.044900 0.99400
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 11 6.11e-01 0.088500 0.99400
REACTOME TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 82 6.12e-01 -0.032400 0.99400
REACTOME SIGNALING BY NOTCH3 48 6.12e-01 -0.042300 0.99400
REACTOME GLUCAGON TYPE LIGAND RECEPTORS 32 6.12e-01 0.051800 0.99400
REACTOME RHOT1 GTPASE CYCLE 5 6.13e-01 0.131000 0.99400
REACTOME ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 10 6.13e-01 -0.092400 0.99400
REACTOME REGULATION OF INSULIN SECRETION 77 6.14e-01 0.033300 0.99400
REACTOME RHOBTB1 GTPASE CYCLE 22 6.14e-01 -0.062100 0.99400
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION 10 6.15e-01 0.091900 0.99400
REACTOME SUMOYLATION OF TRANSCRIPTION FACTORS 20 6.15e-01 -0.065000 0.99400
REACTOME IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 17 6.16e-01 -0.070300 0.99400
REACTOME SIGNALING BY WNT IN CANCER 32 6.16e-01 -0.051300 0.99400
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 16 6.16e-01 -0.072500 0.99400
REACTOME RA BIOSYNTHESIS PATHWAY 22 6.16e-01 0.061800 0.99400
REACTOME EICOSANOIDS 12 6.16e-01 -0.083600 0.99400
REACTOME DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 39 6.17e-01 0.046300 0.99400
REACTOME INTERLEUKIN 37 SIGNALING 20 6.17e-01 0.064600 0.99400
REACTOME CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 6.17e-01 0.083400 0.99400
REACTOME MUSCLE CONTRACTION 197 6.17e-01 -0.020700 0.99400
REACTOME HDL ASSEMBLY 8 6.18e-01 0.102000 0.99400
REACTOME DUAL INCISION IN GG NER 39 6.19e-01 0.046100 0.99400
REACTOME GRB7 EVENTS IN ERBB2 SIGNALING 5 6.19e-01 -0.129000 0.99400
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS 18 6.19e-01 -0.067800 0.99400
REACTOME SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 6.19e-01 0.082800 0.99400
REACTOME NTRK2 ACTIVATES RAC1 5 6.20e-01 0.128000 0.99400
REACTOME RAB GERANYLGERANYLATION 57 6.20e-01 0.038000 0.99400
REACTOME ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 93 6.20e-01 -0.029700 0.99400
REACTOME SMAC XIAP REGULATED APOPTOTIC RESPONSE 7 6.20e-01 -0.108000 0.99400
REACTOME PEROXISOMAL LIPID METABOLISM 28 6.21e-01 -0.054100 0.99400
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 52 6.21e-01 0.039700 0.99400
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH PI3K 6 6.22e-01 -0.116000 0.99400
REACTOME CALCITONIN LIKE LIGAND RECEPTORS 10 6.24e-01 -0.089500 0.99400
REACTOME SIGNALING BY ROBO RECEPTORS 206 6.24e-01 -0.019800 0.99400
REACTOME PLASMA LIPOPROTEIN CLEARANCE 37 6.25e-01 0.046500 0.99400
REACTOME PHASE 2 PLATEAU PHASE 14 6.25e-01 -0.075500 0.99400
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 67 6.25e-01 0.034500 0.99400
REACTOME COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 98 6.26e-01 -0.028500 0.99400
REACTOME ACYL CHAIN REMODELLING OF PS 22 6.26e-01 -0.060000 0.99400
REACTOME PI3K EVENTS IN ERBB2 SIGNALING 16 6.27e-01 0.070200 0.99400
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 9 6.27e-01 0.093600 0.99400
REACTOME CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 25 6.29e-01 0.055800 0.99400
REACTOME SIGNAL TRANSDUCTION BY L1 20 6.30e-01 0.062300 0.99400
REACTOME VESICLE MEDIATED TRANSPORT 642 6.30e-01 0.011100 0.99400
REACTOME ACTIVATION OF RAS IN B CELLS 5 6.30e-01 -0.124000 0.99400
REACTOME BIOTIN TRANSPORT AND METABOLISM 10 6.31e-01 0.087800 0.99400
REACTOME TRIF MEDIATED PROGRAMMED CELL DEATH 9 6.31e-01 -0.092500 0.99400
REACTOME P75NTR SIGNALS VIA NF KB 15 6.33e-01 0.071300 0.99400
REACTOME LIPID PARTICLE ORGANIZATION 6 6.34e-01 -0.112000 0.99400
REACTOME REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 53 6.34e-01 0.037800 0.99400
REACTOME DEFECTS IN BIOTIN BTN METABOLISM 8 6.35e-01 0.097000 0.99400
REACTOME COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 32 6.35e-01 -0.048500 0.99400
REACTOME CIRCADIAN CLOCK 68 6.36e-01 -0.033200 0.99400
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 30 6.36e-01 -0.050000 0.99400
REACTOME FATTY ACID METABOLISM 170 6.36e-01 0.021100 0.99400
REACTOME NEGATIVE REGULATION OF FLT3 15 6.36e-01 0.070500 0.99400
REACTOME DARPP 32 EVENTS 24 6.39e-01 -0.055300 0.99400
REACTOME METABOLISM OF COFACTORS 19 6.40e-01 -0.062100 0.99400
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 14 6.42e-01 0.071700 0.99400
REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 6.43e-01 -0.064900 0.99400
REACTOME MAPK1 ERK2 ACTIVATION 9 6.44e-01 0.089000 0.99400
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS 10 6.44e-01 0.084400 0.99400
REACTOME PLATELET AGGREGATION PLUG FORMATION 39 6.45e-01 0.042700 0.99400
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS 5 6.45e-01 0.119000 0.99400
REACTOME GLUCOSE METABOLISM 90 6.45e-01 0.028100 0.99400
REACTOME MTORC1 MEDIATED SIGNALLING 23 6.46e-01 0.055400 0.99400
REACTOME POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 27 6.46e-01 0.051100 0.99400
REACTOME SIGNALING BY SCF KIT 42 6.46e-01 0.040900 0.99400
REACTOME SYNTHESIS OF DNA 119 6.47e-01 0.024300 0.99400
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 9 6.49e-01 0.087500 0.99400
REACTOME LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 6.50e-01 0.060200 0.99400
REACTOME DEGRADATION OF GLI1 BY THE PROTEASOME 59 6.50e-01 -0.034100 0.99400
REACTOME RHO GTPASES ACTIVATE ROCKS 19 6.51e-01 0.060000 0.99400
REACTOME CHYLOMICRON ASSEMBLY 10 6.51e-01 0.082600 0.99400
REACTOME INTERLEUKIN 21 SIGNALING 9 6.52e-01 -0.086900 0.99400
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION 9 6.52e-01 0.086800 0.99400
REACTOME SIGNALING BY FGFR4 IN DISEASE 11 6.53e-01 -0.078300 0.99400
REACTOME ZINC TRANSPORTERS 15 6.53e-01 0.067100 0.99400
REACTOME SUPPRESSION OF PHAGOSOMAL MATURATION 13 6.53e-01 0.072000 0.99400
REACTOME ERBB2 REGULATES CELL MOTILITY 15 6.53e-01 0.067100 0.99400
REACTOME DNA DAMAGE BYPASS 47 6.53e-01 0.037900 0.99400
REACTOME ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 42 6.53e-01 0.040000 0.99400
REACTOME RUNX2 REGULATES CHONDROCYTE MATURATION 5 6.54e-01 -0.116000 0.99400
REACTOME SIGNALING BY RNF43 MUTANTS 8 6.54e-01 0.091500 0.99400
REACTOME INTERLEUKIN 6 SIGNALING 11 6.54e-01 0.078000 0.99400
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES 8 6.56e-01 -0.091100 0.99400
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 57 6.57e-01 -0.034000 0.99400
REACTOME KERATAN SULFATE KERATIN METABOLISM 34 6.57e-01 0.044000 0.99400
REACTOME EXTRA NUCLEAR ESTROGEN SIGNALING 74 6.58e-01 0.029800 0.99400
REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES 22 6.58e-01 -0.054400 0.99400
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS 5 6.59e-01 0.114000 0.99400
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS 12 6.59e-01 -0.073600 0.99400
REACTOME N GLYCAN TRIMMING AND ELONGATION IN THE CIS GOLGI 5 6.60e-01 -0.114000 0.99400
REACTOME RECEPTOR MEDIATED MITOPHAGY 10 6.60e-01 -0.080300 0.99400
REACTOME LRR FLII INTERACTING PROTEIN 1 LRRFIP1 ACTIVATES TYPE I IFN PRODUCTION 5 6.61e-01 -0.113000 0.99400
REACTOME VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 6.61e-01 0.049700 0.99400
REACTOME ERYTHROPOIETIN ACTIVATES STAT5 7 6.61e-01 0.095700 0.99400
REACTOME CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 6.62e-01 -0.027600 0.99400
REACTOME LATE SARS COV 2 INFECTION EVENTS 67 6.63e-01 0.030800 0.99400
REACTOME SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 27 6.63e-01 0.048500 0.99400
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 6.64e-01 0.046600 0.99400
REACTOME REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 6.64e-01 0.064800 0.99400
REACTOME SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 8 6.65e-01 -0.088400 0.99400
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 6.66e-01 -0.066700 0.99400
REACTOME HYDROLYSIS OF LPC 9 6.66e-01 -0.083000 0.99400
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 11 6.67e-01 0.074900 0.99400
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 19 6.67e-01 -0.057000 0.99400
REACTOME NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 20 6.67e-01 -0.055500 0.99400
REACTOME PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 74 6.68e-01 -0.028800 0.99500
REACTOME 2 LTR CIRCLE FORMATION 7 6.70e-01 -0.092900 0.99500
REACTOME FORMATION OF APOPTOSOME 10 6.70e-01 0.077700 0.99500
REACTOME SYNTHESIS OF DOLICHYL PHOSPHATE 6 6.71e-01 -0.100000 0.99500
REACTOME ETHANOL OXIDATION 12 6.72e-01 -0.070600 0.99500
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 122 6.72e-01 -0.022200 0.99500
REACTOME NONCANONICAL ACTIVATION OF NOTCH3 8 6.74e-01 0.085900 0.99500
REACTOME RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 6.74e-01 -0.050600 0.99500
REACTOME SYNTHESIS OF PA 38 6.75e-01 0.039300 0.99500
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 24 6.75e-01 0.049400 0.99500
REACTOME GLUTATHIONE CONJUGATION 33 6.75e-01 0.042100 0.99500
REACTOME LIGAND RECEPTOR INTERACTIONS 8 6.75e-01 0.085500 0.99500
REACTOME METABOLISM OF POLYAMINES 56 6.76e-01 -0.032300 0.99500
REACTOME RHO GTPASES ACTIVATE PAKS 19 6.76e-01 -0.055300 0.99500
REACTOME PYRUVATE METABOLISM 29 6.77e-01 0.044800 0.99500
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES 12 6.78e-01 0.069200 0.99500
REACTOME DAP12 SIGNALING 27 6.78e-01 0.046200 0.99500
REACTOME MYOGENESIS 29 6.79e-01 0.044400 0.99500
REACTOME DEVELOPMENTAL BIOLOGY 1115 6.80e-01 0.007320 0.99500
REACTOME INFLAMMASOMES 21 6.80e-01 -0.052000 0.99500
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 6.80e-01 0.061500 0.99500
REACTOME REGULATION OF RAS BY GAPS 66 6.81e-01 -0.029300 0.99500
REACTOME METABOLISM OF STEROID HORMONES 35 6.83e-01 -0.039900 0.99500
REACTOME GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 14 6.84e-01 0.062900 0.99500
REACTOME TRYPTOPHAN CATABOLISM 14 6.85e-01 -0.062600 0.99500
REACTOME METABOLISM OF VITAMINS AND COFACTORS 185 6.86e-01 0.017200 0.99500
REACTOME EPH EPHRIN MEDIATED REPULSION OF CELLS 50 6.86e-01 0.033000 0.99500
REACTOME RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 22 6.86e-01 0.049800 0.99500
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 35 6.86e-01 0.039500 0.99500
REACTOME SCAVENGING OF HEME FROM PLASMA 13 6.87e-01 -0.064600 0.99500
REACTOME MAPK FAMILY SIGNALING CASCADES 314 6.87e-01 0.013200 0.99500
REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 24 6.87e-01 -0.047500 0.99500
REACTOME EXTENSION OF TELOMERES 49 6.89e-01 0.033100 0.99500
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 51 6.89e-01 0.032300 0.99500
REACTOME VEGFR2 MEDIATED CELL PROLIFERATION 19 6.90e-01 -0.052800 0.99500
REACTOME PASSIVE TRANSPORT BY AQUAPORINS 13 6.91e-01 -0.063700 0.99500
REACTOME ACYL CHAIN REMODELING OF CL 5 6.92e-01 0.102000 0.99500
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 17 6.92e-01 -0.055500 0.99500
REACTOME FBXW7 MUTANTS AND NOTCH1 IN CANCER 5 6.93e-01 -0.102000 0.99500
REACTOME LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 11 6.94e-01 0.068500 0.99500
REACTOME SIGNALING BY ALK 26 6.94e-01 0.044500 0.99500
REACTOME G ALPHA Z SIGNALLING EVENTS 48 6.95e-01 -0.032700 0.99500
REACTOME ARYL HYDROCARBON RECEPTOR SIGNALLING 6 6.97e-01 -0.092000 0.99500
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 20 6.97e-01 0.050300 0.99500
REACTOME EPHRIN SIGNALING 17 6.98e-01 -0.054300 0.99500
REACTOME SIGNALING BY MEMBRANE TETHERED FUSIONS OF PDGFRA OR PDGFRB 5 6.98e-01 0.100000 0.99500
REACTOME SENSING OF DNA DOUBLE STRAND BREAKS 6 6.98e-01 -0.091400 0.99500
REACTOME BETA DEFENSINS 27 7.00e-01 0.042900 0.99500
REACTOME SYNTHESIS OF PC 27 7.00e-01 0.042900 0.99500
REACTOME RHOH GTPASE CYCLE 37 7.00e-01 0.036600 0.99500
REACTOME ENDOSOMAL VACUOLAR PATHWAY 11 7.00e-01 -0.067100 0.99500
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 11 7.00e-01 0.067000 0.99500
REACTOME GPER1 SIGNALING 45 7.00e-01 0.033200 0.99500
REACTOME GLYCOSAMINOGLYCAN METABOLISM 118 7.01e-01 0.020400 0.99500
REACTOME PEXOPHAGY 11 7.02e-01 -0.066700 0.99500
REACTOME REGULATED NECROSIS 57 7.03e-01 0.029200 0.99500
REACTOME ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS 7 7.03e-01 0.083100 0.99500
REACTOME NEF AND SIGNAL TRANSDUCTION 8 7.03e-01 0.077700 0.99500
REACTOME REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 5 7.04e-01 0.098000 0.99500
REACTOME TRIGLYCERIDE CATABOLISM 23 7.06e-01 -0.045500 0.99500
REACTOME HDL CLEARANCE 5 7.06e-01 -0.097300 0.99500
REACTOME GABA B RECEPTOR ACTIVATION 43 7.07e-01 0.033200 0.99500
REACTOME FLT3 SIGNALING THROUGH SRC FAMILY KINASES 6 7.07e-01 0.088600 0.99500
REACTOME ORGANIC CATION TRANSPORT 10 7.09e-01 -0.068100 0.99500
REACTOME CYP2E1 REACTIONS 10 7.11e-01 -0.067700 0.99500
REACTOME RRNA PROCESSING 192 7.15e-01 0.015300 0.99500
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS 16 7.15e-01 0.052700 0.99500
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 66 7.16e-01 -0.025900 0.99500
REACTOME CRMPS IN SEMA3A SIGNALING 15 7.16e-01 0.054200 0.99500
REACTOME REDUCTION OF CYTOSOLIC CA LEVELS 11 7.16e-01 0.063300 0.99500
REACTOME STRIATED MUSCLE CONTRACTION 35 7.17e-01 0.035400 0.99500
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 14 7.17e-01 0.056000 0.99500
REACTOME DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 15 7.17e-01 -0.054000 0.99500
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 7.18e-01 0.053900 0.99500
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION 13 7.18e-01 0.057900 0.99500
REACTOME RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION 6 7.18e-01 0.085000 0.99500
REACTOME GLYCOGEN SYNTHESIS 13 7.20e-01 -0.057500 0.99500
REACTOME RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 19 7.20e-01 -0.047500 0.99500
REACTOME TRANSLESION SYNTHESIS BY POLK 17 7.20e-01 -0.050200 0.99500
REACTOME CATION COUPLED CHLORIDE COTRANSPORTERS 7 7.20e-01 -0.078200 0.99500
REACTOME RUNX3 REGULATES WNT SIGNALING 8 7.21e-01 -0.072900 0.99500
REACTOME PEPTIDE HORMONE METABOLISM 84 7.21e-01 0.022500 0.99500
REACTOME NEF MEDIATED CD4 DOWN REGULATION 9 7.23e-01 -0.068100 0.99500
REACTOME SARS COV 2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES 118 7.24e-01 0.018800 0.99500
REACTOME SIGNALING BY MET 78 7.24e-01 -0.023100 0.99500
REACTOME NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 24 7.24e-01 0.041600 0.99500
REACTOME RIP MEDIATED NFKB ACTIVATION VIA ZBP1 16 7.25e-01 -0.050900 0.99500
REACTOME INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 103 7.25e-01 0.020100 0.99500
REACTOME SIGNALING BY MST1 5 7.25e-01 -0.090800 0.99500
REACTOME INTERLEUKIN 6 FAMILY SIGNALING 24 7.27e-01 -0.041100 0.99500
REACTOME DEFECTIVE LFNG CAUSES SCDO3 5 7.30e-01 -0.089200 0.99500
REACTOME RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION 6 7.30e-01 -0.081400 0.99500
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 14 7.30e-01 -0.053200 0.99500
REACTOME SYNTHESIS OF 15 EICOSATETRAENOIC ACID DERIVATIVES 6 7.31e-01 -0.081000 0.99500
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 263 7.31e-01 0.012300 0.99500
REACTOME BILE ACID AND BILE SALT METABOLISM 45 7.33e-01 -0.029400 0.99500
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 11 7.34e-01 0.059100 0.99500
REACTOME MISCELLANEOUS TRANSPORT AND BINDING EVENTS 24 7.34e-01 -0.040000 0.99500
REACTOME SIGNALING BY ERBB2 ECD MUTANTS 16 7.34e-01 -0.049000 0.99500
REACTOME EPH EPHRIN SIGNALING 90 7.36e-01 0.020600 0.99500
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH RAS 8 7.37e-01 -0.068700 0.99500
REACTOME COMPLEX I BIOGENESIS 49 7.37e-01 -0.027800 0.99500
REACTOME MATURATION OF SARS COV 1 SPIKE PROTEIN 5 7.38e-01 0.086400 0.99500
REACTOME INTEGRATION OF ENERGY METABOLISM 105 7.38e-01 0.018900 0.99500
REACTOME IKBA VARIANT LEADS TO EDA ID 6 7.39e-01 -0.078500 0.99500
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE 5 7.39e-01 -0.086000 0.99500
REACTOME GPCR LIGAND BINDING 444 7.39e-01 -0.009210 0.99500
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 361 7.40e-01 0.010200 0.99500
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 93 7.40e-01 -0.019900 0.99500
REACTOME CTLA4 INHIBITORY SIGNALING 21 7.41e-01 0.041700 0.99500
REACTOME TRANSCRIPTION OF THE HIV GENOME 66 7.41e-01 -0.023500 0.99500
REACTOME HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND 55 7.44e-01 -0.025500 0.99500
REACTOME AUTOPHAGY 144 7.45e-01 0.015700 0.99500
REACTOME MET RECEPTOR RECYCLING 10 7.46e-01 0.059200 0.99500
REACTOME SIGNALING BY NTRK2 TRKB 25 7.46e-01 0.037400 0.99500
REACTOME NOSTRIN MEDIATED ENOS TRAFFICKING 5 7.46e-01 -0.083600 0.99500
REACTOME SENSORY PERCEPTION OF SALTY TASTE 6 7.46e-01 0.076200 0.99500
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 29 7.47e-01 -0.034700 0.99500
REACTOME DECTIN 2 FAMILY 26 7.47e-01 0.036600 0.99500
REACTOME CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 7.48e-01 -0.042600 0.99500
REACTOME PI5P REGULATES TP53 ACETYLATION 9 7.48e-01 0.061800 0.99500
REACTOME SIGNALING BY KIT IN DISEASE 20 7.49e-01 0.041300 0.99500
REACTOME REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 89 7.49e-01 0.019600 0.99500
REACTOME SODIUM PROTON EXCHANGERS 7 7.51e-01 -0.069200 0.99500
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM 20 7.51e-01 -0.040900 0.99500
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS 9 7.52e-01 0.060900 0.99500
REACTOME RND2 GTPASE CYCLE 42 7.53e-01 -0.028100 0.99500
REACTOME REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 7.53e-01 0.044100 0.99500
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 54 7.54e-01 -0.024600 0.99500
REACTOME SULFUR AMINO ACID METABOLISM 27 7.55e-01 -0.034700 0.99500
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27 HYDROXYCHOLESTEROL 15 7.55e-01 -0.046500 0.99500
REACTOME NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.55e-01 0.054200 0.99500
REACTOME INTERLEUKIN 15 SIGNALING 13 7.56e-01 0.049800 0.99500
REACTOME METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 7.56e-01 0.046400 0.99500
REACTOME STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING 9 7.56e-01 0.059800 0.99500
REACTOME HOST INTERACTIONS OF HIV FACTORS 127 7.56e-01 0.015900 0.99500
REACTOME GOLGI TO ER RETROGRADE TRANSPORT 132 7.57e-01 -0.015600 0.99500
REACTOME PLATELET SENSITIZATION BY LDL 17 7.58e-01 -0.043200 0.99500
REACTOME MASTL FACILITATES MITOTIC PROGRESSION 10 7.58e-01 -0.056300 0.99500
REACTOME UCH PROTEINASES 99 7.58e-01 0.017900 0.99500
REACTOME NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES 7 7.60e-01 0.066700 0.99500
REACTOME BH3 ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI APOPTOTIC BCL 2 MEMBERS 9 7.60e-01 -0.058800 0.99500
REACTOME INTERLEUKIN 9 SIGNALING 7 7.61e-01 0.066500 0.99500
REACTOME SYNTHESIS OF GDP MANNOSE 5 7.61e-01 0.078600 0.99500
REACTOME TYROSINE CATABOLISM 5 7.61e-01 0.078500 0.99500
REACTOME KETONE BODY METABOLISM 9 7.61e-01 0.058500 0.99500
REACTOME CELL CELL JUNCTION ORGANIZATION 64 7.61e-01 -0.022000 0.99500
REACTOME CLATHRIN MEDIATED ENDOCYTOSIS 139 7.62e-01 -0.014900 0.99500
REACTOME FGFR2 ALTERNATIVE SPLICING 27 7.62e-01 -0.033600 0.99500
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 16 7.63e-01 -0.043600 0.99500
REACTOME ACTIVATION OF SMO 18 7.63e-01 0.041100 0.99500
REACTOME RNA POLYMERASE III TRANSCRIPTION 41 7.63e-01 -0.027200 0.99500
REACTOME PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS 8 7.64e-01 0.061400 0.99500
REACTOME NICOTINAMIDE SALVAGING 19 7.65e-01 0.039600 0.99500
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 7.66e-01 -0.044500 0.99500
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 86 7.66e-01 -0.018600 0.99500
REACTOME SMALL INTERFERING RNA SIRNA BIOGENESIS 9 7.66e-01 -0.057300 0.99500
REACTOME SIGNALING BY MRAS COMPLEX MUTANTS 7 7.66e-01 0.064900 0.99500
REACTOME SUMOYLATION OF DNA REPLICATION PROTEINS 46 7.67e-01 -0.025200 0.99500
REACTOME FATTY ACIDS 15 7.69e-01 0.043700 0.99500
REACTOME INTERLEUKIN 1 PROCESSING 9 7.70e-01 0.056400 0.99500
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 160 7.70e-01 0.013400 0.99500
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY 10 7.70e-01 -0.053400 0.99500
REACTOME CHYLOMICRON REMODELING 10 7.71e-01 -0.053200 0.99500
REACTOME LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX 5 7.71e-01 0.075000 0.99500
REACTOME PLASMA LIPOPROTEIN ASSEMBLY 19 7.71e-01 0.038500 0.99500
REACTOME RHOC GTPASE CYCLE 71 7.74e-01 0.019700 0.99500
REACTOME KERATAN SULFATE BIOSYNTHESIS 28 7.74e-01 0.031400 0.99500
REACTOME G ALPHA 12 13 SIGNALLING EVENTS 74 7.74e-01 -0.019300 0.99500
REACTOME HUR ELAVL1 BINDS AND STABILIZES MRNA 8 7.77e-01 -0.057800 0.99500
REACTOME AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 8 7.77e-01 -0.057700 0.99500
REACTOME INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 14 7.78e-01 0.043600 0.99500
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 7.78e-01 -0.043500 0.99500
REACTOME EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 7.78e-01 0.031300 0.99500
REACTOME CRISTAE FORMATION 27 7.79e-01 -0.031300 0.99500
REACTOME FATTY ACYL COA BIOSYNTHESIS 36 7.79e-01 0.027000 0.99500
REACTOME RRNA PROCESSING IN THE MITOCHONDRION 9 7.79e-01 0.054000 0.99500
REACTOME SIGNALING BY PTK6 54 7.80e-01 0.021900 0.99500
REACTOME SUMOYLATION OF UBIQUITINYLATION PROTEINS 39 7.80e-01 0.025800 0.99500
REACTOME APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 87 7.81e-01 -0.017200 0.99500
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 20 7.82e-01 0.035700 0.99500
REACTOME NICOTINATE METABOLISM 31 7.83e-01 0.028600 0.99500
REACTOME INTERLEUKIN 2 SIGNALING 11 7.83e-01 0.048000 0.99500
REACTOME TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 10 7.83e-01 0.050300 0.99500
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 7.85e-01 0.035300 0.99500
REACTOME LYSINE CATABOLISM 12 7.85e-01 -0.045400 0.99500
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 18 7.86e-01 0.037000 0.99500
REACTOME SHC RELATED EVENTS TRIGGERED BY IGF1R 9 7.87e-01 -0.052100 0.99500
REACTOME GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 7.87e-01 0.031300 0.99500
REACTOME P38MAPK EVENTS 13 7.89e-01 0.042900 0.99500
REACTOME CELL CELL COMMUNICATION 126 7.89e-01 0.013800 0.99500
REACTOME ORC1 REMOVAL FROM CHROMATIN 70 7.89e-01 -0.018500 0.99500
REACTOME DOWNREGULATION OF ERBB4 SIGNALING 9 7.89e-01 -0.051400 0.99500
REACTOME FORMATION OF XYLULOSE 5 PHOSPHATE 5 7.89e-01 -0.069000 0.99500
REACTOME POLYMERASE SWITCHING 13 7.90e-01 0.042700 0.99500
REACTOME PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING 5 7.90e-01 0.068800 0.99500
REACTOME SCAVENGING BY CLASS F RECEPTORS 6 7.91e-01 0.062400 0.99500
REACTOME REGULATION OF SIGNALING BY NODAL 9 7.92e-01 0.050900 0.99500
REACTOME INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 25 7.92e-01 0.030500 0.99500
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL 14 7.93e-01 -0.040500 0.99500
REACTOME CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 7.95e-01 0.045200 0.99500
REACTOME AMINO ACIDS REGULATE MTORC1 53 7.96e-01 -0.020600 0.99500
REACTOME METHYLATION 14 7.96e-01 -0.039900 0.99500
REACTOME ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 24 7.97e-01 0.030400 0.99500
REACTOME SNRNP ASSEMBLY 53 7.98e-01 -0.020400 0.99500
REACTOME KEAP1 NFE2L2 PATHWAY 104 7.98e-01 -0.014500 0.99500
REACTOME INNATE IMMUNE SYSTEM 1002 7.99e-01 0.004750 0.99500
REACTOME SLC TRANSPORTER DISORDERS 94 7.99e-01 -0.015200 0.99500
REACTOME STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 16 8.00e-01 0.036600 0.99500
REACTOME TRAFFICKING OF AMPA RECEPTORS 29 8.00e-01 -0.027100 0.99500
REACTOME PREDNISONE ADME 10 8.01e-01 -0.046100 0.99500
REACTOME PI3K AKT SIGNALING IN CANCER 103 8.03e-01 0.014200 0.99500
REACTOME NUCLEOTIDE BIOSYNTHESIS 14 8.03e-01 0.038400 0.99500
REACTOME CARNITINE METABOLISM 13 8.04e-01 0.039800 0.99500
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 122 8.04e-01 -0.013000 0.99500
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 19 8.04e-01 -0.032800 0.99500
REACTOME HSF1 DEPENDENT TRANSACTIVATION 37 8.05e-01 -0.023400 0.99500
REACTOME INTEGRATION OF PROVIRUS 9 8.05e-01 -0.047400 0.99500
REACTOME ARACHIDONATE PRODUCTION FROM DAG 5 8.06e-01 0.063500 0.99500
REACTOME DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 38 8.06e-01 -0.023100 0.99500
REACTOME PHASE 3 RAPID REPOLARISATION 8 8.06e-01 0.050200 0.99500
REACTOME RNA POLYMERASE I TRANSCRIPTION TERMINATION 30 8.06e-01 -0.025900 0.99500
REACTOME G PROTEIN MEDIATED EVENTS 53 8.07e-01 -0.019400 0.99500
REACTOME TP53 REGULATES METABOLIC GENES 81 8.07e-01 0.015700 0.99500
REACTOME REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 15 8.08e-01 -0.036300 0.99500
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 89 8.09e-01 0.014900 0.99500
REACTOME CA2 ACTIVATED K CHANNELS 9 8.09e-01 -0.046500 0.99500
REACTOME G1 S DNA DAMAGE CHECKPOINTS 67 8.10e-01 -0.017000 0.99500
REACTOME COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 65 8.11e-01 -0.017200 0.99500
REACTOME DISEASES OF IMMUNE SYSTEM 29 8.11e-01 0.025700 0.99500
REACTOME TRIGLYCERIDE METABOLISM 35 8.13e-01 0.023100 0.99500
REACTOME ABC TRANSPORTERS IN LIPID HOMEOSTASIS 17 8.14e-01 -0.033000 0.99500
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 73 8.14e-01 -0.015900 0.99500
REACTOME BETA OXIDATION OF LAUROYL COA TO DECANOYL COA COA 5 8.15e-01 0.060500 0.99500
REACTOME VITAMIN B1 THIAMIN METABOLISM 5 8.15e-01 -0.060400 0.99500
REACTOME CHAPERONE MEDIATED AUTOPHAGY 20 8.15e-01 -0.030200 0.99500
REACTOME REGULATION OF FZD BY UBIQUITINATION 21 8.16e-01 -0.029400 0.99500
REACTOME NCAM1 INTERACTIONS 41 8.17e-01 -0.020900 0.99500
REACTOME DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A 5 8.18e-01 -0.059400 0.99500
REACTOME INTESTINAL ABSORPTION 5 8.20e-01 -0.058900 0.99500
REACTOME BINDING OF TCF LEF CTNNB1 TO TARGET GENE PROMOTERS 8 8.21e-01 0.046300 0.99500
REACTOME CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 100 8.21e-01 -0.013100 0.99500
REACTOME O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 38 8.22e-01 0.021100 0.99500
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 8.22e-01 -0.016500 0.99500
REACTOME ATTENUATION PHASE 27 8.23e-01 -0.024900 0.99500
REACTOME MITOCHONDRIAL PROTEIN IMPORT 58 8.23e-01 -0.017000 0.99500
REACTOME ERK MAPK TARGETS 20 8.24e-01 0.028800 0.99500
REACTOME ACTIVATION OF TRKA RECEPTORS 6 8.24e-01 0.052300 0.99500
REACTOME UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 19 8.27e-01 0.029000 0.99500
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.27e-01 -0.038100 0.99500
REACTOME UNFOLDED PROTEIN RESPONSE UPR 88 8.27e-01 -0.013500 0.99500
REACTOME INLA MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS 9 8.29e-01 -0.041500 0.99500
REACTOME EGFR INTERACTS WITH PHOSPHOLIPASE C GAMMA 9 8.29e-01 -0.041500 0.99500
REACTOME REGULATION OF LIPID METABOLISM BY PPARALPHA 115 8.30e-01 0.011600 0.99500
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 10 8.30e-01 0.039300 0.99500
REACTOME SARS COV 1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES 39 8.33e-01 0.019500 0.99500
REACTOME ENDOGENOUS STEROLS 26 8.33e-01 -0.023900 0.99500
REACTOME FOXO MEDIATED TRANSCRIPTION 65 8.33e-01 0.015100 0.99500
REACTOME WNT MEDIATED ACTIVATION OF DVL 8 8.34e-01 -0.042700 0.99500
REACTOME CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 9 8.35e-01 -0.040200 0.99500
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 62 8.35e-01 0.015300 0.99500
REACTOME POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 8.37e-01 0.023800 0.99500
REACTOME RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 8.38e-01 0.022000 0.99500
REACTOME CHREBP ACTIVATES METABOLIC GENE EXPRESSION 8 8.38e-01 0.041800 0.99500
REACTOME FRUCTOSE METABOLISM 7 8.39e-01 0.044300 0.99500
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 24 8.39e-01 0.023900 0.99500
REACTOME UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 8.39e-01 0.022100 0.99500
REACTOME CREATINE METABOLISM 9 8.41e-01 0.038700 0.99500
REACTOME DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 15 8.42e-01 0.029700 0.99500
REACTOME AZATHIOPRINE ADME 22 8.43e-01 0.024500 0.99500
REACTOME PROTEIN REPAIR 6 8.43e-01 0.046800 0.99500
REACTOME SYNTHESIS OF 16 20 HYDROXYEICOSATETRAENOIC ACIDS HETE 9 8.44e-01 0.037900 0.99500
REACTOME IRAK4 DEFICIENCY TLR2 4 17 8.44e-01 -0.027600 0.99500
REACTOME CONJUGATION OF BENZOATE WITH GLYCINE 6 8.45e-01 -0.046100 0.99500
REACTOME BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 10 8.45e-01 -0.035600 0.99500
REACTOME TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 109 8.46e-01 0.010800 0.99500
REACTOME PHASE 4 RESTING MEMBRANE POTENTIAL 19 8.46e-01 -0.025800 0.99500
REACTOME MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS 7 8.46e-01 0.042400 0.99500
REACTOME PECAM1 INTERACTIONS 12 8.46e-01 -0.032300 0.99500
REACTOME ARMS MEDIATED ACTIVATION 7 8.46e-01 0.042300 0.99500
REACTOME HEME SIGNALING 47 8.47e-01 0.016300 0.99500
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FYN 7 8.47e-01 0.042200 0.99500
REACTOME DEX H BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 7 8.47e-01 0.042100 0.99500
REACTOME SODIUM COUPLED SULPHATE DI AND TRI CARBOXYLATE TRANSPORTERS 5 8.47e-01 -0.049800 0.99500
REACTOME SIGNALING BY NOTCH4 80 8.49e-01 -0.012400 0.99500
REACTOME SARS COV 1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS 16 8.49e-01 0.027500 0.99500
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 69 8.49e-01 -0.013200 0.99500
REACTOME SYNAPTIC ADHESION LIKE MOLECULES 19 8.49e-01 0.025200 0.99500
REACTOME CITRIC ACID CYCLE TCA CYCLE 21 8.50e-01 -0.023800 0.99500
REACTOME REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 72 8.52e-01 -0.012700 0.99500
REACTOME ABACAVIR TRANSMEMBRANE TRANSPORT 5 8.53e-01 -0.047900 0.99500
REACTOME TNFR1 MEDIATED CERAMIDE PRODUCTION 6 8.53e-01 0.043700 0.99500
REACTOME METABOLISM OF FAT SOLUBLE VITAMINS 46 8.53e-01 -0.015700 0.99500
REACTOME VITAMINS 6 8.54e-01 -0.043300 0.99500
REACTOME DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 60 8.55e-01 -0.013600 0.99500
REACTOME GLYCOGEN METABOLISM 22 8.56e-01 0.022400 0.99500
REACTOME ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 8.58e-01 0.032800 0.99500
REACTOME NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER 18 8.58e-01 -0.024400 0.99500
REACTOME TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 10 8.60e-01 0.032200 0.99500
REACTOME DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 8.61e-01 0.022000 0.99500
REACTOME EARLY PHASE OF HIV LIFE CYCLE 14 8.61e-01 0.027000 0.99500
REACTOME LAMININ INTERACTIONS 28 8.62e-01 0.019000 0.99500
REACTOME IRE1ALPHA ACTIVATES CHAPERONES 48 8.62e-01 0.014500 0.99500
REACTOME TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 8.62e-01 0.016100 0.99500
REACTOME MYOCLONIC EPILEPSY OF LAFORA 9 8.62e-01 -0.033400 0.99500
REACTOME STABILIZATION OF P53 56 8.62e-01 -0.013400 0.99500
REACTOME SYNTHESIS OF PE 13 8.63e-01 -0.027700 0.99500
REACTOME GLYCOSPHINGOLIPID METABOLISM 39 8.63e-01 -0.015900 0.99500
REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 9 8.63e-01 -0.033100 0.99500
REACTOME BETA OXIDATION OF PRISTANOYL COA 9 8.64e-01 -0.033000 0.99500
REACTOME SARS COV 2 HOST INTERACTIONS 191 8.64e-01 -0.007170 0.99500
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 37 8.65e-01 -0.016200 0.99500
REACTOME OPIOID SIGNALLING 89 8.65e-01 -0.010400 0.99500
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 8.66e-01 -0.024400 0.99500
REACTOME SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 91 8.66e-01 -0.010300 0.99500
REACTOME ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 8.66e-01 0.025100 0.99500
REACTOME PEPTIDE HORMONE BIOSYNTHESIS 13 8.66e-01 0.026900 0.99500
REACTOME PLATELET HOMEOSTASIS 85 8.67e-01 0.010500 0.99500
REACTOME DETOXIFICATION OF REACTIVE OXYGEN SPECIES 34 8.67e-01 -0.016600 0.99500
REACTOME SUMOYLATION OF INTRACELLULAR RECEPTORS 29 8.68e-01 -0.017800 0.99500
REACTOME PROPIONYL COA CATABOLISM 5 8.69e-01 0.042500 0.99500
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS 7 8.70e-01 -0.035700 0.99500
REACTOME UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 8.70e-01 0.028400 0.99500
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS 7 8.71e-01 -0.035500 0.99500
REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 8.71e-01 -0.022700 0.99500
REACTOME TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 71 8.72e-01 0.011100 0.99500
REACTOME NERVOUS SYSTEM DEVELOPMENT 552 8.72e-01 -0.004010 0.99500
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 8.72e-01 0.029400 0.99500
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 30 8.73e-01 -0.016900 0.99500
REACTOME ANDROGEN BIOSYNTHESIS 11 8.74e-01 0.027600 0.99500
REACTOME PEROXISOMAL PROTEIN IMPORT 62 8.75e-01 0.011600 0.99500
REACTOME HS GAG BIOSYNTHESIS 28 8.75e-01 -0.017200 0.99500
REACTOME SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 54 8.76e-01 0.012300 0.99500
REACTOME SIGNALING BY EGFR 49 8.77e-01 0.012800 0.99500
REACTOME P75NTR REGULATES AXONOGENESIS 9 8.77e-01 0.029800 0.99500
REACTOME TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 17 8.77e-01 0.021600 0.99500
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 183 8.77e-01 0.006620 0.99500
REACTOME NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 8.79e-01 -0.027900 0.99500
REACTOME CELLULAR RESPONSES TO STIMULI 779 8.79e-01 -0.003200 0.99500
REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 8.80e-01 -0.020000 0.99500
REACTOME CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 25 8.80e-01 -0.017400 0.99500
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 32 8.80e-01 0.015400 0.99500
REACTOME DEFECTS IN COBALAMIN B12 METABOLISM 13 8.80e-01 -0.024100 0.99500
REACTOME NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 8.80e-01 -0.025100 0.99500
REACTOME RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES TREGS 9 8.81e-01 0.028900 0.99500
REACTOME MRNA SPLICING 197 8.81e-01 -0.006190 0.99500
REACTOME BIOSYNTHESIS OF EPA DERIVED SPMS 6 8.82e-01 0.034900 0.99500
REACTOME RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS 9 8.83e-01 0.028400 0.99500
REACTOME RUNX3 REGULATES NOTCH SIGNALING 13 8.84e-01 -0.023300 0.99500
REACTOME NEUROTRANSMITTER RELEASE CYCLE 48 8.84e-01 0.012200 0.99500
REACTOME LYSOSPHINGOLIPID AND LPA RECEPTORS 14 8.85e-01 -0.022200 0.99500
REACTOME SIGNALLING TO RAS 20 8.86e-01 0.018600 0.99500
REACTOME RHOBTB2 GTPASE CYCLE 22 8.86e-01 -0.017700 0.99500
REACTOME ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS 5 8.86e-01 -0.037000 0.99500
REACTOME CD209 DC SIGN SIGNALING 20 8.88e-01 0.018200 0.99500
REACTOME HISTIDINE CATABOLISM 8 8.88e-01 -0.028600 0.99500
REACTOME INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 21 8.90e-01 0.017500 0.99500
REACTOME RHO GTPASES ACTIVATE KTN1 11 8.91e-01 -0.023900 0.99500
REACTOME MYD88 INDEPENDENT TLR4 CASCADE 103 8.91e-01 0.007810 0.99500
REACTOME ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 20 8.91e-01 -0.017700 0.99500
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 8.92e-01 -0.008850 0.99500
REACTOME ACYL CHAIN REMODELLING OF PE 29 8.92e-01 0.014600 0.99500
REACTOME SARS COV 1 HOST INTERACTIONS 92 8.92e-01 -0.008200 0.99500
REACTOME LONG TERM POTENTIATION 22 8.93e-01 -0.016500 0.99500
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM 16 8.93e-01 -0.019300 0.99500
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 8.94e-01 -0.008730 0.99500
REACTOME TNF SIGNALING 54 8.94e-01 0.010400 0.99500
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 118 8.95e-01 -0.007050 0.99500
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 28 8.95e-01 0.014400 0.99500
REACTOME TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 41 8.96e-01 0.011800 0.99500
REACTOME ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 8.96e-01 -0.015700 0.99500
REACTOME FORMATION OF AXIAL MESODERM 14 8.97e-01 0.020100 0.99500
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH RAS 9 8.98e-01 0.024600 0.99500
REACTOME TRANSPORT OF NUCLEOTIDE SUGARS 8 8.99e-01 -0.025900 0.99500
REACTOME ACROSOME REACTION AND SPERM OOCYTE MEMBRANE BINDING 6 9.00e-01 -0.029800 0.99500
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 222 9.00e-01 0.004910 0.99500
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 14 9.02e-01 -0.019100 0.99500
REACTOME PLASMA LIPOPROTEIN REMODELING 33 9.02e-01 -0.012400 0.99500
REACTOME REGULATION OF IFNA IFNB SIGNALING 23 9.02e-01 -0.014900 0.99500
REACTOME ENOS ACTIVATION 11 9.02e-01 -0.021500 0.99500
REACTOME ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS 5 9.04e-01 0.031200 0.99500
REACTOME HYALURONAN BIOSYNTHESIS AND EXPORT 5 9.04e-01 -0.031100 0.99500
REACTOME SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 9.04e-01 0.013900 0.99500
REACTOME KILLING MECHANISMS 11 9.04e-01 0.020900 0.99500
REACTOME BICARBONATE TRANSPORTERS 10 9.05e-01 -0.021900 0.99500
REACTOME SIGNALING BY ERBB4 57 9.05e-01 0.009160 0.99500
REACTOME REGULATION OF PTEN LOCALIZATION 8 9.06e-01 -0.024100 0.99500
REACTOME INTRA GOLGI TRAFFIC 43 9.07e-01 0.010300 0.99500
REACTOME ACYL CHAIN REMODELLING OF PC 27 9.07e-01 0.012900 0.99500
REACTOME RNA POLYMERASE II PRE TRANSCRIPTION EVENTS 77 9.08e-01 -0.007620 0.99500
REACTOME G2 M DNA REPLICATION CHECKPOINT 5 9.08e-01 0.029900 0.99500
REACTOME FLT3 SIGNALING BY CBL MUTANTS 7 9.08e-01 -0.025200 0.99500
REACTOME ALPHA OXIDATION OF PHYTANATE 6 9.09e-01 0.027000 0.99500
REACTOME VLDLR INTERNALISATION AND DEGRADATION 16 9.09e-01 -0.016500 0.99500
REACTOME NUCLEOTIDE CATABOLISM 35 9.09e-01 0.011100 0.99500
REACTOMEMATURATION OF SARS COV 1 NUCLEOPROTEIN 11 9.10e-01 -0.019800 0.99500
REACTOME DIGESTION OF DIETARY LIPID 7 9.10e-01 -0.024700 0.99500
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION 20 9.11e-01 0.014400 0.99500
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE 29 9.11e-01 0.011900 0.99500
REACTOME SPRY REGULATION OF FGF SIGNALING 16 9.12e-01 -0.015900 0.99500
REACTOME BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 19 9.12e-01 -0.014600 0.99500
REACTOME GDP FUCOSE BIOSYNTHESIS 6 9.14e-01 0.025500 0.99500
REACTOME MET PROMOTES CELL MOTILITY 41 9.14e-01 0.009760 0.99500
REACTOME DEGRADATION OF AXIN 54 9.14e-01 -0.008460 0.99500
REACTOME RESPONSE TO METAL IONS 14 9.16e-01 -0.016200 0.99500
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING 5 9.17e-01 -0.027000 0.99500
REACTOME DIGESTION OF DIETARY CARBOHYDRATE 6 9.17e-01 -0.024600 0.99500
REACTOME FRUCTOSE CATABOLISM 5 9.17e-01 -0.026800 0.99500
REACTOME DEFENSINS 33 9.18e-01 0.010400 0.99500
REACTOME SARS COV 2 INFECTION 281 9.19e-01 0.003510 0.99500
REACTOME PKA ACTIVATION IN GLUCAGON SIGNALLING 17 9.19e-01 0.014200 0.99500
REACTOME VIRAL MESSENGER RNA SYNTHESIS 44 9.20e-01 0.008740 0.99500
REACTOME TRANSPORT OF RCBL WITHIN THE BODY 8 9.22e-01 -0.020100 0.99500
REACTOME REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 19 9.22e-01 -0.013000 0.99500
REACTOME EARLY SARS COV 2 INFECTION EVENTS 34 9.22e-01 0.009700 0.99500
REACTOME SUMOYLATION OF SUMOYLATION PROTEINS 35 9.22e-01 0.009560 0.99500
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 20 9.22e-01 0.012600 0.99500
REACTOME MINERALOCORTICOID BIOSYNTHESIS 6 9.23e-01 0.022700 0.99500
REACTOME POU5F1 OCT4 SOX2 NANOG ACTIVATE GENES RELATED TO PROLIFERATION 11 9.23e-01 -0.016800 0.99500
REACTOME MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 15 9.24e-01 -0.014300 0.99500
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 9.24e-01 0.016600 0.99500
REACTOME REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 9.25e-01 0.017200 0.99500
REACTOME TCR SIGNALING 113 9.26e-01 0.005080 0.99500
REACTOME DSCAM INTERACTIONS 11 9.28e-01 0.015700 0.99500
REACTOME NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 11 9.28e-01 0.015700 0.99500
REACTOME PERK REGULATES GENE EXPRESSION 31 9.29e-01 -0.009250 0.99500
REACTOME ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 28 9.29e-01 -0.009710 0.99500
REACTOME METHIONINE SALVAGE PATHWAY 6 9.29e-01 0.020900 0.99500
REACTOME IRF3 MEDIATED INDUCTION OF TYPE I IFN 13 9.29e-01 -0.014200 0.99500
REACTOME PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 9.29e-01 -0.013700 0.99500
REACTOME PHASE 1 INACTIVATION OF FAST NA CHANNELS 6 9.30e-01 -0.020600 0.99500
REACTOME NEF MEDIATED CD8 DOWN REGULATION 7 9.30e-01 0.019000 0.99500
REACTOME SIGNALING BY HEDGEHOG 148 9.31e-01 -0.004120 0.99500
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS 21 9.32e-01 -0.010800 0.99500
REACTOME NOD1 2 SIGNALING PATHWAY 33 9.33e-01 0.008410 0.99500
REACTOME PTK6 PROMOTES HIF1A STABILIZATION 6 9.34e-01 0.019700 0.99500
REACTOME CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 9.34e-01 -0.006880 0.99500
REACTOME HEDGEHOG LIGAND BIOGENESIS 64 9.34e-01 0.005950 0.99500
REACTOME HSF1 ACTIVATION 29 9.34e-01 -0.008820 0.99500
REACTOME CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 13 9.35e-01 0.013100 0.99500
REACTOME NUCLEAR SIGNALING BY ERBB4 32 9.35e-01 -0.008290 0.99500
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 63 9.37e-01 -0.005790 0.99500
REACTOME REGULATION OF PTEN STABILITY AND ACTIVITY 67 9.38e-01 -0.005510 0.99500
REACTOME UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN 6 9.38e-01 0.018300 0.99500
REACTOME FCERI MEDIATED NF KB ACTIVATION 78 9.38e-01 0.005060 0.99500
REACTOME LGI ADAM INTERACTIONS 14 9.40e-01 -0.011700 0.99500
REACTOME RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA 7 9.40e-01 -0.016500 0.99500
REACTOME RHOG GTPASE CYCLE 71 9.40e-01 -0.005170 0.99500
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 45 9.40e-01 0.006450 0.99500
REACTOME TACHYKININ RECEPTORS BIND TACHYKININS 5 9.42e-01 -0.018900 0.99500
REACTOME INTERLEUKIN 17 SIGNALING 66 9.42e-01 -0.005210 0.99500
REACTOME PKMTS METHYLATE HISTONE LYSINES 64 9.42e-01 -0.005250 0.99500
REACTOME TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 9.42e-01 -0.005340 0.99500
REACTOME ACTIVATION OF CASPASES THROUGH APOPTOSOME MEDIATED CLEAVAGE 5 9.44e-01 0.018100 0.99600
REACTOME MODULATION BY MTB OF HOST IMMUNE SYSTEM 6 9.45e-01 -0.016200 0.99700
REACTOME TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 55 9.46e-01 0.005250 0.99700
REACTOME ERBB2 ACTIVATES PTK6 SIGNALING 13 9.49e-01 -0.010300 0.99800
REACTOME SCAVENGING BY CLASS B RECEPTORS 6 9.49e-01 0.015200 0.99800
REACTOME RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 58 9.49e-01 0.004870 0.99800
REACTOME SHC1 EVENTS IN ERBB2 SIGNALING 22 9.49e-01 -0.007880 0.99800
REACTOME REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA CARBOXYLATED PROTEINS 8 9.50e-01 0.012800 0.99800
REACTOME REGULATION OF IFNG SIGNALING 14 9.52e-01 0.009290 0.99900
REACTOME TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 16 9.53e-01 0.008500 0.99900
REACTOME REACTIONS SPECIFIC TO THE COMPLEX N GLYCAN SYNTHESIS PATHWAY 10 9.54e-01 0.010500 0.99900
REACTOME RNA POLYMERASE II TRANSCRIPTION TERMINATION 62 9.56e-01 0.004090 0.99900
REACTOME ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 9.56e-01 -0.010100 0.99900
REACTOME RUNX3 REGULATES CDKN1A TRANSCRIPTION 7 9.56e-01 -0.012100 0.99900
REACTOME REGULATION OF NF KAPPA B SIGNALING 17 9.57e-01 0.007610 0.99900
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 9.57e-01 0.007470 0.99900
REACTOME INTERLEUKIN 27 SIGNALING 11 9.58e-01 0.009230 0.99900
REACTOME HIV TRANSCRIPTION INITIATION 43 9.58e-01 -0.004610 0.99900
REACTOME HEME BIOSYNTHESIS 13 9.59e-01 -0.008180 0.99900
REACTOME SHC1 EVENTS IN EGFR SIGNALING 14 9.60e-01 0.007780 0.99900
REACTOME ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 27 9.61e-01 0.005450 0.99900
REACTOME BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA 5 9.62e-01 0.012300 0.99900
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 14 9.62e-01 -0.007320 0.99900
REACTOME METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 33 9.62e-01 0.004740 0.99900
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 26 9.64e-01 0.005180 0.99900
REACTOME CONSTITUTIVE SIGNALING BY EGFRVIII 15 9.66e-01 0.006420 0.99900
REACTOME NUCLEAR ENVELOPE NE REASSEMBLY 74 9.66e-01 0.002890 0.99900
REACTOME TELOMERE EXTENSION BY TELOMERASE 22 9.66e-01 -0.005290 0.99900
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 78 9.67e-01 0.002740 0.99900
REACTOME SIGNALING BY ERBB2 IN CANCER 26 9.67e-01 -0.004710 0.99900
REACTOME ACYL CHAIN REMODELING OF DAG AND TAG 5 9.68e-01 0.010500 0.99900
REACTOME HEDGEHOG ON STATE 85 9.68e-01 -0.002500 0.99900
REACTOME TBC RABGAPS 40 9.69e-01 -0.003500 0.99900
REACTOME RRNA MODIFICATION IN THE MITOCHONDRION 6 9.70e-01 -0.008760 0.99900
REACTOME EGFR DOWNREGULATION 30 9.71e-01 -0.003870 0.99900
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 9.71e-01 -0.002860 0.99900
REACTOME BUTYROPHILIN BTN FAMILY INTERACTIONS 12 9.71e-01 0.005990 0.99900
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 30 9.71e-01 -0.003790 0.99900
REACTOME FORMATION OF PARAXIAL MESODERM 22 9.71e-01 0.004410 0.99900
REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES 507 9.73e-01 -0.000882 0.99900
REACTOME LIPOPHAGY 9 9.73e-01 -0.006450 0.99900
REACTOME IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN 5 9.74e-01 0.008400 0.99900
REACTOME CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 16 9.74e-01 -0.004620 0.99900
REACTOME SOS MEDIATED SIGNALLING 7 9.75e-01 0.006970 0.99900
REACTOME PARACETAMOL ADME 26 9.75e-01 0.003590 0.99900
REACTOME CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 9.76e-01 -0.005160 0.99900
REACTOME SYNTHESIS OF 5 EICOSATETRAENOIC ACIDS 9 9.77e-01 0.005590 0.99900
REACTOME CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 77 9.78e-01 0.001850 0.99900
REACTOME SIGNALING BY EGFR IN CANCER 25 9.80e-01 0.002960 0.99900
REACTOME ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 20 9.81e-01 -0.003010 0.99900
REACTOME SIGNALING BY MAPK MUTANTS 6 9.82e-01 0.005300 0.99900
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.83e-01 0.003240 0.99900
REACTOME RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 9.83e-01 0.003350 0.99900
REACTOME ANCHORING FIBRIL FORMATION 13 9.83e-01 -0.003390 0.99900
REACTOME ESTROGEN STIMULATED SIGNALING THROUGH PRKCZ 6 9.84e-01 -0.004790 0.99900
REACTOME FOLDING OF ACTIN BY CCT TRIC 10 9.84e-01 -0.003660 0.99900
REACTOME RESPONSE OF MTB TO PHAGOCYTOSIS 22 9.85e-01 -0.002370 0.99900
REACTOME RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 47 9.85e-01 0.001540 0.99900
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 9.86e-01 0.001170 0.99900
REACTOME SARS COV 2 MODULATES AUTOPHAGY 11 9.86e-01 -0.002990 0.99900
REACTOME FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 17 9.87e-01 -0.002320 0.99900
REACTOME EPHB MEDIATED FORWARD SIGNALING 41 9.87e-01 -0.001490 0.99900
REACTOME DUAL INCISION IN TC NER 63 9.87e-01 -0.001190 0.99900
REACTOME E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 58 9.87e-01 -0.001210 0.99900
REACTOME NETRIN 1 SIGNALING 49 9.88e-01 -0.001280 0.99900
REACTOME MITOCHONDRIAL UNCOUPLING 5 9.89e-01 -0.003620 0.99900
REACTOME VITAMIN B2 RIBOFLAVIN METABOLISM 7 9.89e-01 -0.003050 0.99900
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 299 9.89e-01 -0.000465 0.99900
REACTOME TRNA MODIFICATION IN THE MITOCHONDRION 8 9.89e-01 0.002740 0.99900
REACTOME ORGANIC ANION TRANSPORTERS 10 9.89e-01 -0.002410 0.99900
REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX 32 9.90e-01 -0.001330 0.99900
REACTOME SYNTHESIS OF PI 5 9.90e-01 -0.003350 0.99900
REACTOME NGF INDEPENDANT TRKA ACTIVATION 5 9.91e-01 0.003020 0.99900
REACTOME ER TO GOLGI ANTEROGRADE TRANSPORT 152 9.92e-01 -0.000477 0.99900
REACTOME SYNTHESIS OF KETONE BODIES 8 9.93e-01 0.001910 0.99900
REACTOME COBALAMIN CBL METABOLISM 7 9.93e-01 0.002040 0.99900
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX3 94 9.93e-01 -0.000491 0.99900
REACTOME THE NLRP3 INFLAMMASOME 16 9.94e-01 -0.001100 0.99900
REACTOME CONDENSATION OF PROMETAPHASE CHROMOSOMES 11 9.95e-01 -0.001110 0.99900
REACTOME MICRORNA MIRNA BIOGENESIS 25 9.97e-01 -0.000499 0.99900
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 9 9.97e-01 -0.000818 0.99900
REACTOME LDL CLEARANCE 19 9.97e-01 -0.000436 0.99900
REACTOME FANCONI ANEMIA PATHWAY 35 9.97e-01 -0.000320 0.99900
REACTOME SIGNALING BY ERBB2 50 9.98e-01 -0.000246 0.99900
REACTOME DAP12 INTERACTIONS 37 9.99e-01 0.000135 1.00000
REACTOME GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 35 9.99e-01 0.000091 1.00000
REACTOME DISSOLUTION OF FIBRIN CLOT 13 1.00e+00 0.000021 1.00000


Detailed Gene set reports



REACTOME_SENSORY_PERCEPTION

REACTOME_SENSORY_PERCEPTION
1581
set REACTOME_SENSORY_PERCEPTION
setSize 555
pANOVA 1.94e-06
s.dist -0.118
p.adjustANOVA 0.00318



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR4K13 -11648
OR10J3 -11642
OR52E6 -11601
OR1K1 -11597
TAS2R14 -11573
GRXCR2 -11521
OR2Y1 -11499
OR8H3 -11496
OR8D2 -11495
CLPS -11492
OR1S2 -11488
OR51F2 -11475
OR6Q1 -11435
TAS2R31 -11408
OR2T12 -11315
OR2T11 -11301
OR2S2 -11276
RHO -11267
OR4X2 -11255
OR52I1 -11253

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR4K13 -11648.0
OR10J3 -11642.0
OR52E6 -11601.0
OR1K1 -11597.0
TAS2R14 -11573.0
GRXCR2 -11521.0
OR2Y1 -11499.0
OR8H3 -11496.0
OR8D2 -11495.0
CLPS -11492.0
OR1S2 -11488.0
OR51F2 -11475.0
OR6Q1 -11435.0
TAS2R31 -11408.0
OR2T12 -11315.0
OR2T11 -11301.0
OR2S2 -11276.0
RHO -11267.0
OR4X2 -11255.0
OR52I1 -11253.0
OR6A2 -11236.0
OR5H1 -11229.0
OR4B1 -11224.0
LRRC52 -11217.0
OPN1SW -11200.0
OR6C68 -11180.0
OR13C2 -11179.0
OR51B6 -11177.0
RTP1 -11158.0
OR52H1 -11155.0
OR6C3 -11138.0
OR8U3 -11137.0
OR2L3 -11127.0
GUCA1C -11120.0
OR51V1 -11074.0
OR6C74 -11064.0
OR13D1 -11060.0
OR6B3 -11058.0
OR5H6 -11050.0
CALHM3 -11045.0
RBP3 -10984.0
PNLIP -10981.0
TAS2R40 -10973.0
OR10S1 -10950.0
OR12D2 -10936.0
OR2M4 -10923.0
OTOG -10910.0
OR6N2 -10884.0
RCVRN -10873.0
TAS2R7 -10870.0
OR8B12 -10844.0
GUCA1A -10808.0
OR51A7 -10788.0
OR2AG1 -10780.0
TAS2R10 -10714.0
STRC -10700.0
OR2D2 -10651.0
OR4D6 -10633.0
OR4E2 -10602.0
OR2L5 -10540.0
OR2B6 -10522.0
STRA6 -10512.0
RTP2 -10505.0
OR4K5 -10498.0
GNAT3 -10495.0
OR4F15 -10485.0
OR56B4 -10482.0
OR56A3 -10474.0
OR4K15 -10427.0
OR2W3 -10384.0
OR6C2 -10381.0
OR10A4 -10360.0
OR9I1 -10354.0
OR6X1 -10351.0
OR5AP2 -10328.0
SDC3 -10286.0
OR6C75 -10266.0
OR52D1 -10254.0
OR9A2 -10240.0
OR8J3 -10228.0
OR51D1 -10187.0
OR51L1 -10157.0
HSD17B1 -10152.0
OR2F2 -10136.0
OTOGL -10121.0
OR2V1 -10107.0
OR51I1 -10061.0
CABP2 -10050.0
OR10C1 -10023.0
OR56A1 -10022.0
OR2M3 -10020.0
OR13C8 -9950.0
TAS1R3 -9946.0
OR3A2 -9850.0
OR2H2 -9836.0
OR1L8 -9794.0
OR5J2 -9775.0
APOC3 -9743.0
OR8K3 -9732.0
OR10H5 -9717.0
OR1S1 -9685.0
RDH16 -9671.0
OR10G7 -9653.0
OR4L1 -9639.0
OR5H2 -9607.0
OR4C3 -9589.0
OR11H4 -9582.0
OR5AN1 -9548.0
BSN -9539.0
OR1C1 -9534.0
OR10J1 -9525.0
RGS9BP -9508.0
OR52B6 -9495.0
OR2AK2 -9440.0
OR13C4 -9365.0
STX1A -9360.0
OR10A7 -9337.0
OR10G2 -9336.0
GNGT1 -9287.0
OR10A3 -9280.0
OR51A2 -9238.0
OR51G1 -9132.0
OR3A1 -9128.0
OR5D13 -8922.0
TAS2R16 -8857.0
OR1D2 -8829.0
OR8G1 -8816.0
OR10A2 -8791.0
OR5AU1 -8674.0
OR52R1 -8672.0
RDH12 -8652.0
AGRN -8628.0
TMC2 -8567.0
OR5F1 -8523.0
OR1L6 -8454.0
ESPNL -8447.0
SCN3A -8404.0
OR52E4 -8398.0
OR51T1 -8222.0
HSD17B6 -8208.0
MYO15A -8197.0
OR6B1 -8112.0
OR5V1 -7910.0
APOC2 -7859.0
OR52B2 -7854.0
HSPG2 -7846.0
OR5D14 -7825.0
OR9G4 -7759.0
PJVK -7730.0
TRPM5 -7724.0
TAS2R41 -7661.0
PDE6B -7649.0
GRM4 -7631.0
XIRP2 -7608.0
RLBP1 -7601.0
OR10H2 -7571.0
CACNA2D2 -7551.0
OR4K14 -7546.0
OR2T3 -7469.0
OR13J1 -7468.0
OR8J1 -7459.0
OR8B4 -7450.0
OR6C1 -7343.0
OR2B2 -7289.0
TAS2R39 -7282.0
TAS2R5 -7273.0
CYP4V2 -7265.0
RETSAT -7168.0
OR6M1 -7138.0
OR13C9 -7129.0
OR6F1 -7119.0
OR52A1 -7095.0
OR5K3 -6981.0
ABCA4 -6908.0
OR7G1 -6824.0
GUCA1B -6684.0
OR1M1 -6671.0
OTOP1 -6620.0
SLC24A1 -6610.0
OR10X1 -6607.0
TWF2 -6572.0
OR2M7 -6536.0
KCNMA1 -6430.0
SCNN1B -6429.0
OR2M5 -6361.0
OR9Q1 -6334.0
OR5K1 -6221.0
OR5D18 -6204.0
TAS2R8 -6196.0
OR51E1 -6172.0
OR8U8 -6094.0
OR8K5 -6080.0
OR10A5 -6075.0
OR52L1 -6035.0
OR2H1 -6013.0
KCNQ4 -5975.0
OR5AC2 -5945.0
OR6V1 -5883.0
CAMKMT -5877.0
ACTG1 -5857.0
AKR1C4 -5750.0
GNAT1 -5677.0
OR6N1 -5673.0
OR14I1 -5647.0
RDH8 -5593.0
OR2L2 -5544.0
GNB1 -5542.0
OR14J1 -5521.0
OR56B1 -5507.0
RGS9 -5471.0
ATP2B2 -5455.0
OR10H4 -5440.0
FNTA -5313.0
OR8B2 -5288.0
OR5K2 -5278.0
OR2A5 -5262.0
TAS2R46 -5231.0
OR9K2 -5161.0
OR2AT4 -5064.0
MYO3B -5049.0
LRP2 -4997.0
OR6T1 -4929.0
CNGA1 -4919.0
CAPZB -4876.0
OR1N1 -4849.0
OR4K2 -4768.0
OR51S1 -4753.0
MYO7A -4640.0
OR10W1 -4543.0
OR2L13 -4540.0
PDE6G -4530.0
OR4C16 -4429.0
EPB41L1 -4391.0
CHRNA9 -4373.0
APOA2 -4355.0
CDH23 -4317.0
OR2W1 -4262.0
LRP1 -4172.0
MYH9 -4157.0
ITPR3 -4089.0
RDH10 -4084.0
OR1F1 -3981.0
CTBP2 -3925.0
TAS1R2 -3920.0
GPC1 -3808.0
BCO2 -3773.0
OR8H1 -3683.0
OR10AG1 -3680.0
OR11H6 -3605.0
OR7D2 -3580.0
OR6K2 -3557.0
OR8K1 -3531.0
NMT2 -3529.0
OR51E2 -3484.0
PCDH15 -3461.0
OR13F1 -3378.0
OR10Z1 -3336.0
APOA4 -3324.0
OR52A5 -3309.0
OR2D3 -3272.0
GNB5 -3181.0
OR12D3 -3126.0
OR10AD1 -3074.0
TWF1 -2967.0
OR5M11 -2928.0
OR9A4 -2926.0
OR10Q1 -2923.0
OR5M10 -2910.0
SDC1 -2906.0
RDX -2882.0
OR1L1 -2879.0
TMC1 -2872.0
OR6C4 -2863.0
GPC2 -2818.0
OR4C46 -2687.0
OR11A1 -2661.0
VAMP2 -2659.0
OR8D1 -2656.0
CALM1 -2630.0
SLC17A8 -2608.0
LPL -2495.0
OR1L4 -2489.0
CHRNA10 -2482.0
OR7D4 -2473.0
OR6C70 -2450.0
EPS8L2 -2429.0
OR10G3 -2272.0
OR52M1 -2242.0
ESPN -2232.0
BCO1 -2229.0
TAS2R38 -2180.0
OR2L8 -2091.0
KCNN2 -2041.0
GRK1 -2035.0
EPS8 -2015.0
LRP12 -2005.0
EPB41L3 -1972.0
DNAJC5 -1967.0
OR13G1 -1855.0
OR4D1 -1851.0
OTOF -1842.0
PCLO -1774.0
TRIOBP -1748.0
OR10V1 -1685.0
CACNA1D -1662.0
OR1J2 -1604.0
ANO2 -1513.0
PLS1 -1509.0
USH1C -1507.0
OR5B2 -1503.0
GRXCR1 -1307.0
OR52J3 -1291.0
OR52N1 -1224.0
OR51B4 -1165.0
OR7A10 -1146.0
OR51B2 -1120.0
OR2B11 -1083.0
OR4C15 -1053.0
OR10G4 -949.0
AKR1B10 -892.0
OR11G2 -855.0
OR2C3 -839.0
SNAP25 -822.0
OR5L1 -788.0
OR52W1 -781.0
OR5M9 -692.0
SCNN1A -688.0
OR5A1 -661.0
OR4S1 -656.0
CACNB2 -566.0
OR6S1 -459.0
GRK7 -396.0
SPTBN1 -338.0
NMT1 -146.0
OR5T2 -114.0
TAS2R1 -47.0
OR2T1 -18.0
REEP1 64.0
OR2A2 151.0
APOM 175.0
OR3A3 191.0
OR2A14 422.0
TAS2R20 450.0
GPC6 479.0
LDLR 580.0
LDB1 601.0
SCN2B 648.0
OR6K3 669.0
OR5AR1 682.0
LRP8 698.0
RBP1 713.0
OR2T4 728.0
SCN4B 763.0
OR2G3 794.0
FNTB 854.0
OR2G2 888.0
OR4C45 926.0
GRK4 962.0
CAPZA1 973.0
TAS2R50 1027.0
OR5AK2 1083.0
OR2T33 1127.0
RBP2 1179.0
SCN2A 1202.0
CAPZA2 1226.0
GNAL 1231.0
OR1E1 1343.0
MYO3A 1371.0
PRKCQ 1412.0
USH1G 1484.0
OR51B5 1558.0
CLIC5 1570.0
OR4D10 1584.0
SDC2 1596.0
GPIHBP1 1719.0
OR6K6 1829.0
OR6C65 1856.0
OR8D4 1870.0
OR2V2 2072.0
OR2F1 2164.0
EBF1 2238.0
OR5L2 2254.0
OR4K1 2411.0
TMIE 2426.0
GRM1 2495.0
EZR 2513.0
OR2B3 2602.0
CIB2 2619.0
OR14C36 2627.0
OR7C2 2679.0
DHRS9 2703.0
CNGB1 2718.0
MYO1C 2747.0
OR2T8 2777.0
OR1B1 2856.0
AKR1C3 2861.0
GPC5 2943.0
TAS1R1 2946.0
OR5M1 2953.0
OR1I1 3042.0
NAPEPLD 3187.0
GNB3 3205.0
OR1E2 3230.0
OR51M1 3269.0
OR8U1 3299.0
SDC4 3350.0
OR13C3 3399.0
RDH11 3408.0
DHRS3 3421.0
SPTAN1 3489.0
OR2T6 3547.0
OR10A6 3554.0
SCN9A 3572.0
TPRN 3688.0
OR5B12 3725.0
SAG 3802.0
CABP1 3844.0
SCNN1D 3877.0
RAB3A 3898.0
OR51I2 3959.0
GNG13 4000.0
OR5M3 4032.0
PRKCA 4097.0
LHFPL5 4114.0
OR4C12 4125.0
OR6C76 4160.0
OR4N5 4210.0
OR52E8 4341.0
OR4X1 4461.0
LRAT 4471.0
SLC26A5 4561.0
METAP1 4756.0
OR10J5 4894.0
RBP4 4953.0
OR13A1 4999.0
OR2T27 5012.0
APOB 5074.0
OR1N2 5166.0
OR1G1 5248.0
RPE65 5253.0
PLCB2 5402.0
OR7A5 5413.0
OR4K17 5441.0
OR5D16 5519.0
OR2Z1 5524.0
OR5K4 5616.0
RIPOR2 5619.0
OR9Q2 5647.0
OR5A2 5655.0
OR2G6 5671.0
OR4M1 5672.0
GSN 5720.0
LHX2 5723.0
OR2M2 5773.0
KCNJ2 5777.0
TRPM4 5784.0
LRP10 5794.0
TAS2R30 5798.0
OR10T2 5803.0
TTR 5864.0
WHRN 5921.0
OR1Q1 6000.0
RDH5 6042.0
OR2J2 6044.0
OR11L1 6049.0
PDE6A 6083.0
ACTB 6159.0
OR6C6 6210.0
SCN1B 6298.0
SCNN1G 6316.0
OR1L3 6397.0
OR52K1 6524.0
ADCY3 6766.0
OR6B2 6948.0
OR5B21 6958.0
OR6Y1 7163.0
OR8S1 7207.0
OR51G2 7465.0
OR7G3 7474.0
APOA1 7545.0
OR56A5 7617.0
OR8A1 7684.0
OR51Q1 7737.0
OR6P1 7949.0
OR5P2 7981.0
OR7E24 7995.0
OR2AE1 8005.0
OR5AS1 8016.0
PLB1 8131.0
SDR9C7 8179.0
OR4D9 8188.0
OR1J1 8212.0
OR1A1 8268.0
OR4F6 8286.0
OR52N2 8291.0
OR5I1 8292.0
GUCY2D 8326.0
OR7G2 8333.0
OR8G5 8357.0
OR5B17 8366.0
OR4C6 8442.0
OR10G9 8526.0
OR4A5 8707.0
OR2C1 8729.0
OR2AG2 8769.0
CNGA4 8772.0
OR9G1 8850.5
OR9G9 8850.5
CALHM1 8907.0
OR5W2 8989.0
OR7A17 9015.0
FSCN2 9021.0
OR1A2 9043.0
OR4D2 9060.0
AKR1C1 9069.0
OR2A12 9091.0
ATP2B1 9150.0
OR5M8 9152.0
METAP2 9154.0
OR2K2 9218.0
OR4A15 9232.0
OR56A4 9244.0
APOE 9271.0
OR4A16 9283.0
OR10H3 9291.0
OR4D5 9350.0
OR5P3 9371.0
OR5B3 9400.0
OR8B8 9401.0
OR14A16 9428.0
TAS2R3 9429.0
OR52E2 9486.0
OR5T1 9487.0
TAS2R13 9492.0
OR51F1 9504.0
OR52I2 9582.0
OR4D11 9608.0
OR4N2 9616.0
OR10G8 9648.0
OR10K1 9697.0
OR10H1 9770.0
TAS2R4 9782.0
OR2AP1 9817.0
OR1J4 9846.0
OR7C1 9866.0
KCNMB1 9882.0
OR52K2 9926.0
OR10P1 10001.0
OR5H15 10025.0
OR8I2 10059.0
TAS2R43 10084.0
OR5C1 10101.0
OR5T3 10128.0
OR10K2 10203.0
OR4A47 10231.0


REACTOME_OLFACTORY_SIGNALING_PATHWAY

REACTOME_OLFACTORY_SIGNALING_PATHWAY
628
set REACTOME_OLFACTORY_SIGNALING_PATHWAY
setSize 348
pANOVA 0.000338
s.dist -0.112
p.adjustANOVA 0.277



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR4K13 -11648
OR10J3 -11642
OR52E6 -11601
OR1K1 -11597
OR2Y1 -11499
OR8H3 -11496
OR8D2 -11495
OR1S2 -11488
OR51F2 -11475
OR6Q1 -11435
OR2T12 -11315
OR2T11 -11301
OR2S2 -11276
OR4X2 -11255
OR52I1 -11253
OR6A2 -11236
OR5H1 -11229
OR4B1 -11224
OR6C68 -11180
OR13C2 -11179

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR4K13 -11648.0
OR10J3 -11642.0
OR52E6 -11601.0
OR1K1 -11597.0
OR2Y1 -11499.0
OR8H3 -11496.0
OR8D2 -11495.0
OR1S2 -11488.0
OR51F2 -11475.0
OR6Q1 -11435.0
OR2T12 -11315.0
OR2T11 -11301.0
OR2S2 -11276.0
OR4X2 -11255.0
OR52I1 -11253.0
OR6A2 -11236.0
OR5H1 -11229.0
OR4B1 -11224.0
OR6C68 -11180.0
OR13C2 -11179.0
OR51B6 -11177.0
RTP1 -11158.0
OR52H1 -11155.0
OR6C3 -11138.0
OR8U3 -11137.0
OR2L3 -11127.0
OR51V1 -11074.0
OR6C74 -11064.0
OR13D1 -11060.0
OR6B3 -11058.0
OR5H6 -11050.0
OR10S1 -10950.0
OR12D2 -10936.0
OR2M4 -10923.0
OR6N2 -10884.0
OR8B12 -10844.0
OR51A7 -10788.0
OR2AG1 -10780.0
OR2D2 -10651.0
OR4D6 -10633.0
OR4E2 -10602.0
OR2L5 -10540.0
OR2B6 -10522.0
RTP2 -10505.0
OR4K5 -10498.0
OR4F15 -10485.0
OR56B4 -10482.0
OR56A3 -10474.0
OR4K15 -10427.0
OR2W3 -10384.0
OR6C2 -10381.0
OR10A4 -10360.0
OR9I1 -10354.0
OR6X1 -10351.0
OR5AP2 -10328.0
OR6C75 -10266.0
OR52D1 -10254.0
OR9A2 -10240.0
OR8J3 -10228.0
OR51D1 -10187.0
OR51L1 -10157.0
OR2F2 -10136.0
OR2V1 -10107.0
OR51I1 -10061.0
OR10C1 -10023.0
OR56A1 -10022.0
OR2M3 -10020.0
OR13C8 -9950.0
OR3A2 -9850.0
OR2H2 -9836.0
OR1L8 -9794.0
OR5J2 -9775.0
OR8K3 -9732.0
OR10H5 -9717.0
OR1S1 -9685.0
OR10G7 -9653.0
OR4L1 -9639.0
OR5H2 -9607.0
OR4C3 -9589.0
OR11H4 -9582.0
OR5AN1 -9548.0
OR1C1 -9534.0
OR10J1 -9525.0
OR52B6 -9495.0
OR2AK2 -9440.0
OR13C4 -9365.0
OR10A7 -9337.0
OR10G2 -9336.0
OR10A3 -9280.0
OR51A2 -9238.0
OR51G1 -9132.0
OR3A1 -9128.0
OR5D13 -8922.0
OR1D2 -8829.0
OR8G1 -8816.0
OR10A2 -8791.0
OR5AU1 -8674.0
OR52R1 -8672.0
OR5F1 -8523.0
OR1L6 -8454.0
OR52E4 -8398.0
OR51T1 -8222.0
OR6B1 -8112.0
OR5V1 -7910.0
OR52B2 -7854.0
OR5D14 -7825.0
OR9G4 -7759.0
OR10H2 -7571.0
OR4K14 -7546.0
OR2T3 -7469.0
OR13J1 -7468.0
OR8J1 -7459.0
OR8B4 -7450.0
OR6C1 -7343.0
OR2B2 -7289.0
OR6M1 -7138.0
OR13C9 -7129.0
OR6F1 -7119.0
OR52A1 -7095.0
OR5K3 -6981.0
OR7G1 -6824.0
OR1M1 -6671.0
OR10X1 -6607.0
OR2M7 -6536.0
OR2M5 -6361.0
OR9Q1 -6334.0
OR5K1 -6221.0
OR5D18 -6204.0
OR51E1 -6172.0
OR8U8 -6094.0
OR8K5 -6080.0
OR10A5 -6075.0
OR52L1 -6035.0
OR2H1 -6013.0
OR5AC2 -5945.0
OR6V1 -5883.0
OR6N1 -5673.0
OR14I1 -5647.0
OR2L2 -5544.0
GNB1 -5542.0
OR14J1 -5521.0
OR56B1 -5507.0
OR10H4 -5440.0
OR8B2 -5288.0
OR5K2 -5278.0
OR2A5 -5262.0
OR9K2 -5161.0
OR2AT4 -5064.0
OR6T1 -4929.0
OR1N1 -4849.0
OR4K2 -4768.0
OR51S1 -4753.0
OR10W1 -4543.0
OR2L13 -4540.0
OR4C16 -4429.0
OR2W1 -4262.0
OR1F1 -3981.0
OR8H1 -3683.0
OR10AG1 -3680.0
OR11H6 -3605.0
OR7D2 -3580.0
OR6K2 -3557.0
OR8K1 -3531.0
OR51E2 -3484.0
OR13F1 -3378.0
OR10Z1 -3336.0
OR52A5 -3309.0
OR2D3 -3272.0
OR12D3 -3126.0
OR10AD1 -3074.0
OR5M11 -2928.0
OR9A4 -2926.0
OR10Q1 -2923.0
OR5M10 -2910.0
OR1L1 -2879.0
OR6C4 -2863.0
OR4C46 -2687.0
OR11A1 -2661.0
OR8D1 -2656.0
OR1L4 -2489.0
OR7D4 -2473.0
OR6C70 -2450.0
OR10G3 -2272.0
OR52M1 -2242.0
OR2L8 -2091.0
OR13G1 -1855.0
OR4D1 -1851.0
OR10V1 -1685.0
OR1J2 -1604.0
ANO2 -1513.0
OR5B2 -1503.0
OR52J3 -1291.0
OR52N1 -1224.0
OR51B4 -1165.0
OR7A10 -1146.0
OR51B2 -1120.0
OR2B11 -1083.0
OR4C15 -1053.0
OR10G4 -949.0
OR11G2 -855.0
OR2C3 -839.0
OR5L1 -788.0
OR52W1 -781.0
OR5M9 -692.0
OR5A1 -661.0
OR4S1 -656.0
OR6S1 -459.0
OR5T2 -114.0
OR2T1 -18.0
REEP1 64.0
OR2A2 151.0
OR3A3 191.0
OR2A14 422.0
LDB1 601.0
OR6K3 669.0
OR5AR1 682.0
OR2T4 728.0
OR2G3 794.0
OR2G2 888.0
OR4C45 926.0
OR5AK2 1083.0
OR2T33 1127.0
GNAL 1231.0
OR1E1 1343.0
OR51B5 1558.0
OR4D10 1584.0
OR6K6 1829.0
OR6C65 1856.0
OR8D4 1870.0
OR2V2 2072.0
OR2F1 2164.0
EBF1 2238.0
OR5L2 2254.0
OR4K1 2411.0
OR2B3 2602.0
OR14C36 2627.0
OR7C2 2679.0
CNGB1 2718.0
OR2T8 2777.0
OR1B1 2856.0
OR5M1 2953.0
OR1I1 3042.0
OR1E2 3230.0
OR51M1 3269.0
OR8U1 3299.0
OR13C3 3399.0
OR2T6 3547.0
OR10A6 3554.0
OR5B12 3725.0
OR51I2 3959.0
GNG13 4000.0
OR5M3 4032.0
OR4C12 4125.0
OR6C76 4160.0
OR4N5 4210.0
OR52E8 4341.0
OR4X1 4461.0
OR10J5 4894.0
OR13A1 4999.0
OR2T27 5012.0
OR1N2 5166.0
OR1G1 5248.0
OR7A5 5413.0
OR4K17 5441.0
OR5D16 5519.0
OR2Z1 5524.0
OR5K4 5616.0
OR9Q2 5647.0
OR5A2 5655.0
OR2G6 5671.0
OR4M1 5672.0
LHX2 5723.0
OR2M2 5773.0
OR10T2 5803.0
OR1Q1 6000.0
OR2J2 6044.0
OR11L1 6049.0
OR6C6 6210.0
OR1L3 6397.0
OR52K1 6524.0
ADCY3 6766.0
OR6B2 6948.0
OR5B21 6958.0
OR6Y1 7163.0
OR8S1 7207.0
OR51G2 7465.0
OR7G3 7474.0
OR56A5 7617.0
OR8A1 7684.0
OR51Q1 7737.0
OR6P1 7949.0
OR5P2 7981.0
OR7E24 7995.0
OR2AE1 8005.0
OR5AS1 8016.0
OR4D9 8188.0
OR1J1 8212.0
OR1A1 8268.0
OR4F6 8286.0
OR52N2 8291.0
OR5I1 8292.0
OR7G2 8333.0
OR8G5 8357.0
OR5B17 8366.0
OR4C6 8442.0
OR10G9 8526.0
OR4A5 8707.0
OR2C1 8729.0
OR2AG2 8769.0
CNGA4 8772.0
OR9G1 8850.5
OR9G9 8850.5
OR5W2 8989.0
OR7A17 9015.0
OR1A2 9043.0
OR4D2 9060.0
OR2A12 9091.0
OR5M8 9152.0
OR2K2 9218.0
OR4A15 9232.0
OR56A4 9244.0
OR4A16 9283.0
OR10H3 9291.0
OR4D5 9350.0
OR5P3 9371.0
OR5B3 9400.0
OR8B8 9401.0
OR14A16 9428.0
OR52E2 9486.0
OR5T1 9487.0
OR51F1 9504.0
OR52I2 9582.0
OR4D11 9608.0
OR4N2 9616.0
OR10G8 9648.0
OR10K1 9697.0
OR10H1 9770.0
OR2AP1 9817.0
OR1J4 9846.0
OR7C1 9866.0
OR52K2 9926.0
OR10P1 10001.0
OR5H15 10025.0
OR8I2 10059.0
OR5C1 10101.0
OR5T3 10128.0
OR10K2 10203.0
OR4A47 10231.0


REACTOME_CD22_MEDIATED_BCR_REGULATION

REACTOME_CD22_MEDIATED_BCR_REGULATION
1007
set REACTOME_CD22_MEDIATED_BCR_REGULATION
setSize 5
pANOVA 0.000701
s.dist 0.875
p.adjustANOVA 0.384



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD22 9937
CD79A 9546
CD79B 9354
PTPN6 8056
LYN 7833

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD22 9937
CD79A 9546
CD79B 9354
PTPN6 8056
LYN 7833


REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES
159
set REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES
setSize 30
pANOVA 0.00157
s.dist -0.333
p.adjustANOVA 0.489



Top enriched genes

Top 20 genes
GeneID Gene Rank
CMA1 -11344
CTRB2 -11288
MMP7 -11156
PLG -10695
CTRB1 -10554
CTSV -10437
MMP14 -9479
MMP16 -9444
MMP3 -9382
PRSS1 -8713
MMP11 -8464
ELANE -7993
MMP17 -7975
CTSG -7778
COL18A1 -7044
MMP24 -6677
KLKB1 -5810
TIMP2 -5285
SPOCK3 -5171
MMP2 -5141

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CMA1 -11344
CTRB2 -11288
MMP7 -11156
PLG -10695
CTRB1 -10554
CTSV -10437
MMP14 -9479
MMP16 -9444
MMP3 -9382
PRSS1 -8713
MMP11 -8464
ELANE -7993
MMP17 -7975
CTSG -7778
COL18A1 -7044
MMP24 -6677
KLKB1 -5810
TIMP2 -5285
SPOCK3 -5171
MMP2 -5141
MMP25 -3008
MMP13 326
KLK2 848
MMP9 1503
MMP15 3752
MMP10 4123
MMP1 7081
CTSK 7136
FURIN 7787
MMP8 9887


REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION
1024
set REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION
setSize 1356
pANOVA 0.0018
s.dist 0.0505
p.adjustANOVA 0.489



Top enriched genes

Top 20 genes
GeneID Gene Rank
SPRN 10236
H2AC14 10039
A4GNT 10026
GOLM1 9984
H2BC6 9804
SERPIND1 9803
KBTBD6 9789
TGFBR1 9787
DYNLL2 9781
SPON2 9740
AREG 9730
PRSS41 9725
CHML 9707
SMURF2 9689
GALNT8 9650
MBD6 9628
RAB13 9619
H4C9 9566
GOSR1 9473
OTUD7A 9449

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SPRN 10236.0
H2AC14 10039.0
A4GNT 10026.0
GOLM1 9984.0
H2BC6 9804.0
SERPIND1 9803.0
KBTBD6 9789.0
TGFBR1 9787.0
DYNLL2 9781.0
SPON2 9740.0
AREG 9730.0
PRSS41 9725.0
CHML 9707.0
SMURF2 9689.0
GALNT8 9650.0
MBD6 9628.0
RAB13 9619.0
H4C9 9566.0
GOSR1 9473.0
OTUD7A 9449.0
RAB12 9434.0
TMED3 9422.0
YOD1 9417.0
GALNT12 9403.0
SELENOS 9349.0
ZNF350 9314.0
USP7 9312.0
H4C5 9308.0
ARF3 9299.0
APOE 9271.0
H4C6 9192.0
GGCX 9188.0
H2BC14 9173.0
RAB22A 9140.0
AAAS 9113.0
IZUMO1R 9109.0
KLHL42 9080.0
COMMD3 9033.0
FUCA2 9025.0
KAT2A 9007.0
NUP93 8999.0
PSMB6 8978.0
USP21 8968.0
B3GNT7 8954.0
CHST4 8928.0
H2AC4 8927.0
ALG10 8919.0
RAB39A 8895.0
ASB3 8812.0
FEM1C 8809.0
B3GNT5 8802.0
DCAF13 8793.0
RAB24 8792.0
LY6G6D 8788.0
ANKRD9 8763.0
COMMD4 8723.0
ASB17 8720.0
DMP1 8666.0
RFT1 8660.0
MAN2A1 8645.0
COG3 8634.0
H2BC4 8612.0
PIGC 8588.0
HDAC1 8575.0
H2BC12 8544.0
KAT2B 8522.0
LYPD4 8506.0
RABGGTB 8505.0
KLHL20 8494.0
DPH7 8493.0
LY6K 8490.0
ALG11 8462.0
HLTF 8435.0
TRIM4 8416.0
CPM 8398.0
B3GNT8 8356.0
APP 8327.0
RAD18 8322.0
POLB 8304.0
VWA1 8281.0
PIGL 8269.0
CANX 8192.0
COMMD10 8191.0
RAB21 8187.0
BABAM2 8186.0
H2AC6 8154.0
CGA 8150.0
EPAS1 8145.0
COMMD2 8116.0
SPSB3 8106.0
IKBKE 8098.0
UBE2K 8071.0
SBSPON 8066.0
PIGW 8044.0
ARSK 8036.0
RAB18 8003.0
USP19 7983.0
PTRH2 7975.0
MUC20 7945.0
ADAMTS5 7943.0
MFGE8 7938.0
FBXW12 7907.0
NEURL2 7897.0
TRAPPC10 7889.0
PSMB2 7872.0
TRAF3 7838.0
PCGF2 7831.0
FURIN 7787.0
CDK1 7783.0
COL7A1 7748.0
CAND1 7719.0
OTULIN 7679.0
BST1 7675.0
PSMC3 7659.0
SUMF2 7643.0
RNF123 7621.0
RAET1G 7616.0
ZBTB16 7604.0
ARSI 7592.0
RAB7A 7589.0
MSLN 7576.0
H2AC15 7566.0
ST6GALNAC4 7552.0
APOA1 7545.0
RAB37 7531.0
USP18 7529.0
ALG10B 7526.0
COPS5 7523.0
H2BC15 7521.0
BGLAP 7519.0
CBX8 7514.0
C3 7498.0
FBXL12 7496.0
SEC16B 7473.0
TOP2B 7455.0
FBXO4 7448.0
UBXN7 7443.0
FBXW5 7433.0
DDB2 7393.0
SLC35C1 7344.0
MYSM1 7335.0
PEX13 7333.0
TRAPPC3 7331.0
ASB14 7308.0
TRAPPC1 7281.0
ST3GAL2 7265.0
USP24 7251.0
PRND 7245.0
USP15 7240.0
NOD2 7228.0
SERPINA1 7203.0
MRTFA 7147.0
UBE2H 7122.0
CHD3 7121.0
AMFR 7105.0
FBXW4 7087.0
ASB16 7082.0
DPH2 7057.0
HIPK2 7047.0
H4C16 7045.0
NLRP3 7029.0
FBXO40 7021.0
USP48 7012.0
FBXW8 7009.0
P4HB 6991.0
FBXL18 6990.0
CTSA 6984.0
H2BC13 6942.0
UBE2Q2 6935.0
KBTBD7 6926.0
RUVBL1 6916.0
NAPA 6913.0
NR1H3 6906.0
FEM1B 6867.0
PSMA5 6863.0
BMI1 6855.0
PIGM 6826.0
CD52 6818.0
NR1I2 6805.0
TTLL13 6800.0
SEL1L 6796.0
PSMA4 6785.0
MLEC 6775.0
GMPPA 6770.0
TUBA3D 6758.0
NCOA1 6757.0
KLHL3 6749.0
HRC 6739.0
FBXO7 6725.0
ZRANB1 6715.0
RANGAP1 6692.0
ARSB 6691.0
LEO1 6689.0
FBXL4 6658.0
MATN3 6654.0
CISH 6645.0
ST6GAL1 6602.0
TPST2 6583.0
SMAD3 6582.0
H2AC13 6574.0
WDR20 6551.0
SENP5 6511.0
CDC25A 6510.0
USP10 6496.0
ADAMTSL1 6464.0
NUP58 6427.0
ADAMTS20 6367.0
ASB8 6362.0
DCAF7 6317.0
PEX10 6308.0
KDELR2 6294.0
RAE1 6280.0
B3GNT3 6250.0
DYNC1I1 6233.0
SCG2 6232.0
ANKRD28 6224.0
RAB5A 6217.0
FBXO41 6213.0
H2AC12 6195.0
CCN1 6189.0
CBX4 6169.0
ACTB 6159.0
NSF 6148.0
NPM1 6135.0
THRB 6127.0
MARCHF6 6122.0
ADAMTS1 6110.0
COMMD5 6025.0
MIA3 6016.0
H4C8 6011.0
CBX5 6007.0
SATB2 5997.0
PRSS23 5981.0
GALNT10 5978.0
TTLL5 5964.0
ALPL 5944.0
PIGH 5909.0
ATXN3 5878.0
CLSPN 5858.0
IL6 5855.0
SPTBN5 5850.0
FBXO44 5848.0
RECK 5846.0
VDAC3 5825.0
POMGNT2 5816.0
SMC5 5810.0
ALG14 5802.0
RAB30 5801.0
COMMD7 5731.0
TFAP2C 5725.0
ST8SIA4 5711.0
HNRNPC 5675.0
GALNT13 5674.0
SEC24B 5666.0
SRD5A3 5662.0
PIGS 5654.0
USP42 5644.0
SMAD1 5630.0
ADAMTSL4 5615.0
PSMF1 5602.0
KCTD6 5601.0
UCHL3 5586.0
TUBB4A 5584.0
COMMD8 5561.0
PREB 5555.0
MPI 5554.0
SPON1 5550.0
KBTBD8 5535.0
MIA2 5499.0
STC2 5495.0
SEH1L 5491.0
NUP210 5481.0
NUP43 5466.0
FBXW2 5462.0
AXIN2 5457.0
PSMC1 5450.0
ARRB1 5446.0
PGR 5440.0
SIAH2 5437.0
ST3GAL4 5434.0
TAB1 5403.0
POM121C 5401.0
H2AC25 5376.0
MPDU1 5358.0
C4A 5353.5
ADAMTS19 5298.0
NAPG 5241.0
RNF7 5213.0
VDR 5209.0
RARA 5184.0
MXRA8 5170.0
CNTN4 5164.0
MBTPS1 5148.0
LY6G6C 5124.0
TUBAL3 5121.0
TNKS2 5118.0
MDM4 5114.0
HNRNPK 5091.0
MDM2 5079.0
APOB 5074.0
ARSA 5062.0
EDEM3 5031.0
TRAPPC5 5015.0
TAF10 4993.0
GOLGA2 4973.0
B4GALT1 4941.0
MAN2A2 4920.0
NOTUM 4915.0
RCE1 4913.0
ST6GALNAC6 4889.0
OS9 4856.0
SAE1 4847.0
PSMA8 4836.0
TTLL3 4835.0
B3GALNT2 4825.0
CCNA1 4815.0
DCAF11 4804.0
SPTA1 4802.0
DCAF4 4788.0
NGLY1 4773.0
COP1 4770.0
USP13 4768.0
STAM 4766.0
NRN1L 4760.0
DCAF8 4743.0
FSTL1 4732.0
LYPD1 4718.0
LAMC1 4715.0
WAC 4709.0
SEC22B 4703.0
PSMA1 4692.0
MUC7 4682.0
B4GALT5 4681.0
TFAP2A 4650.0
FBN1 4614.0
POMGNT1 4613.0
H4C3 4600.0
NUP62 4592.0
TP53BP1 4581.0
GMPPB 4542.0
SQSTM1 4535.0
ZNF131 4527.0
DTL 4513.0
VNN2 4501.0
DCTN2 4497.0
GMDS 4476.0
SMC3 4451.0
SAFB 4447.0
USP33 4414.0
DDOST 4408.0
DCUN1D5 4403.0
MUC5AC 4371.0
PPARGC1A 4347.0
PSMA7 4345.0
ST8SIA3 4342.0
KDELR3 4328.0
DERL1 4318.0
CDCA8 4262.0
COPB1 4261.0
DPM1 4239.0
SSPOP 4236.0
CTBP1 4233.0
BRCA1 4231.0
GALNT7 4223.0
NUP50 4208.0
ENAM 4206.0
NUP155 4169.0
OTUD3 4157.0
TOP1 4134.0
USP37 4116.0
NR5A2 4066.0
DDB1 4053.0
F7 4048.0
PIGB 4021.0
DYNC1LI2 4016.0
OTUB2 3994.0
RNF5 3973.0
PSME4 3949.0
FOLR2 3945.0
ADAMTS10 3916.0
RNF139 3903.0
RAB3A 3898.0
PPARG 3882.0
RING1 3881.0
SUZ12 3880.0
SMAD2 3835.0
TUSC3 3832.0
UBE2W 3818.0
H4C4 3780.0
FBXL15 3769.0
MAN1A1 3756.0
HDAC4 3726.0
PDIA6 3713.0
DPP3 3706.0
PLAUR 3694.0
POMT2 3687.0
FBXO11 3679.0
DNMT3B 3676.0
PEX14 3656.0
TPGS2 3645.0
LAMB2 3641.0
TNIP3 3609.0
RAB2A 3582.0
WDTC1 3578.0
CCP110 3574.0
IFIH1 3555.0
ST6GALNAC3 3544.0
CKAP4 3542.0
FBXO22 3531.0
DYNC1H1 3523.0
TUBB2A 3522.0
TUBB4B 3511.0
DYNC1I2 3507.0
ALG9 3498.0
SPTAN1 3489.0
COG5 3481.0
MUCL1 3476.0
RPN2 3475.0
LMAN2 3469.0
NUP88 3461.0
RAD52 3441.0
CTSZ 3424.0
PPARA 3420.0
B3GNT2 3412.0
HIF1A 3378.0
RAB20 3371.0
H2BC26 3341.0
THRA 3339.0
ST6GALNAC2 3334.0
NRIP1 3332.0
GFPT1 3314.0
PSMB7 3305.0
USP49 3288.0
VGF 3284.0
SEC22A 3278.0
RIGI 3274.0
INO80B 3273.0
RAB29 3208.0
MCRS1 3196.0
TRAPPC6B 3176.0
SEC23A 3175.0
GNE 3149.0
ADAMTS8 3141.0
CYLD 3134.0
MELTF 3123.0
SOCS6 3120.0
NFE2L2 3115.0
RAB38 3089.0
WRN 3067.0
FBXO2 3066.0
TADA2B 3059.0
DOHH 3053.0
UBA2 2996.0
RAB14 2991.0
MGAT1 2988.0
PSMC6 2973.0
DOLK 2971.0
H4C1 2954.0
NFRKB 2940.0
RNF135 2928.0
APLP2 2922.0
HDAC2 2921.0
ADAMTS7 2907.0
TOPORS 2904.0
AXIN1 2896.0
AGBL5 2892.0
PSMD7 2868.0
ART3 2855.0
SENP8 2799.0
CUL4A 2793.0
ADAMTS9 2779.0
ELOB 2769.0
SCFD1 2753.0
INO80 2743.0
PSMB1 2738.0
CD55 2737.0
TUBB1 2727.0
UBA6 2698.0
TULP4 2692.0
DCAF17 2682.0
KLHL5 2680.0
UBE2F 2676.0
DPH3 2674.0
GALNT11 2638.0
SP100 2610.0
TRIM13 2575.0
DNAJC3 2550.0
DCTN1 2525.0
STAG1 2515.0
FAM20A 2514.0
POMK 2507.0
MTA1 2479.0
INS 2470.0
SOCS5 2469.0
ARF1 2458.0
CDC20 2446.0
MYC 2434.0
FN3K 2428.0
STAMBPL1 2425.0
KDM1B 2422.0
RAB34 2417.0
YY1 2413.0
SPP1 2404.0
SLC35A1 2401.0
CAPZA3 2399.0
B4GALT4 2398.0
MAVS 2391.0
UBE2D3 2387.0
USP2 2382.0
RBBP5 2378.0
WSB2 2365.0
NR3C1 2348.0
MEPE 2347.0
RNF152 2326.0
COG8 2283.0
NSMCE3 2281.0
MAN1C1 2275.0
USP20 2270.0
PSCA 2262.0
FOXK2 2259.0
PGAP1 2220.0
TFAP2B 2211.0
PIAS1 2206.0
DCAF5 2176.0
GATA3 2129.0
DCAF10 2116.0
SLC17A5 2107.0
UBE2L3 2106.0
SNX3 2100.0
GFUS 2092.0
RAB5B 2085.0
CBX2 2064.0
CDKN1A 2061.0
DNMT3A 2025.0
NR3C2 2006.0
CHST10 2004.0
PLET1 1998.0
GALNT2 1932.0
SVBP 1919.0
POMT1 1889.0
BIRC2 1880.0
NUP35 1878.0
MUC17 1874.0
RIPK1 1868.0
PNPLA2 1867.0
KLHL21 1837.0
VASH2 1810.0
CALR 1804.0
RHOA 1803.0
BCL10 1788.0
JOSD1 1780.0
TMEM115 1761.0
PIGG 1756.0
AGBL3 1754.0
UIMC1 1750.0
UGGT1 1740.0
GPIHBP1 1719.0
MGAT5 1709.0
PPP6R3 1702.0
XRCC4 1686.0
CUL3 1683.0
GOLGB1 1677.0
LGALS1 1648.0
MUC13 1608.0
USP5 1603.0
RNF103 1597.0
SDC2 1596.0
MGAT4A 1592.0
USP30 1522.0
SMAD4 1521.0
CDKN2A 1520.0
KLHL25 1516.0
ST3GAL5 1506.0
NSMCE2 1476.0
CUL9 1469.0
RAB8B 1467.0
B3GLCT 1466.0
EEF1AKMT2 1442.0
ADAMTS3 1418.0
ST8SIA2 1388.0
PSMD14 1372.0
PALB2 1366.0
DPH5 1340.0
TNFAIP3 1332.0
PIAS2 1331.0
NTM 1328.0
MAP3K7 1321.0
RIPK2 1317.0
TFG 1304.0
SPSB1 1303.0
PIGN 1279.0
SKP1 1275.0
CD59 1245.0
NAPB 1234.0
CAPZA2 1226.0
CNTN3 1194.0
ALB 1153.0
NUP214 1146.0
SP3 1144.0
LMAN2L 1140.0
PHC3 1131.0
PIGY 1105.0
F2 1102.0
GAN 1060.0
SEC16A 1041.0
USP47 1037.0
ADAM10 1018.0
COMMD6 1012.0
RAB6A 984.0
CAPZA1 973.0
UBB 959.0
COPG1 950.0
DCUN1D1 949.0
RAD21 929.0
ST6GAL2 922.0
RNF168 921.0
PSMD12 913.0
STAM2 900.0
PRMT3 878.0
USP12 864.0
PIGF 840.0
VCAN 836.0
NTNG2 833.0
MUC6 832.0
VASH1 811.0
UBE2E3 808.0
B4GALT3 776.0
UBE2R2 766.0
SEC31A 759.0
NSMCE1 752.0
CSNK1D 725.0
HSPA8 717.0
TRAF6 630.0
PIGO 628.0
NUP160 623.0
PGM3 593.0
EEF1A1 547.0
GANAB 511.0
LY6H 496.0
PSMA6 489.0
COG4 460.0
COPA 441.0
GALNTL6 439.0
CEACAM5 434.0
TRAPPC9 430.0
H2AC7 427.5
H2BC7 427.5
TPST1 408.0
USP22 374.0
ADAMTS6 367.0
SPTBN4 363.0
RTF1 338.0
SHPRH 327.0
LY6E 309.0
RNF185 301.0
RAB32 295.0
MCFD2 285.0
HIF3A 253.0
PSMB5 238.0
MGAT4B 211.0
EDEM1 176.0
PIGV 165.0
EVA1A 142.0
UBE2G1 139.0
UFD1 127.0
SMC6 108.0
PARP1 99.0
KLHL22 72.0
ST3GAL3 67.0
PIGK 63.0
UGGT2 59.0
GRIA1 42.0
PSME3 41.0
LYPD3 37.0
DCAF6 29.0
RAB10 23.0
LHB 12.0
RAB17 -4.0
TF -11.0
CCNF -29.0
PARK7 -55.0
TRAPPC4 -77.0
RRAGA -80.0
CDC73 -127.0
RAB2B -152.0
TGFA -154.0
DYNC1LI1 -156.0
RNF40 -169.0
TUBA1A -177.0
SCMH1 -184.0
DPH6 -221.0
FBXO27 -238.0
THBS1 -293.0
NUP98 -301.0
PRKCSH -332.0
SPTBN1 -338.0
TP53 -362.0
B3GNT9 -394.0
CNIH2 -411.0
RAB15 -423.0
RAB27A -430.0
ST3GAL1 -432.0
NCOR2 -439.0
CDH2 -460.0
RHOT1 -501.0
DAXX -514.0
DNAJC24 -527.0
PSMA3 -531.0
MDGA2 -541.0
DDA1 -559.0
ACTR10 -578.0
SMAD7 -584.0
PSMD6 -607.0
ARSG -609.0
GPAA1 -621.0
TGFB1 -622.0
ST6GALNAC1 -624.0
UBE2B -628.0
NOD1 -634.0
USP28 -638.0
OBSL1 -653.0
IGFBP4 -655.0
POFUT2 -693.0
INO80D -709.0
CNIH1 -716.0
PIGQ -759.0
RAB8A -761.0
KCTD7 -764.0
NUB1 -797.0
FBXW7 -812.0
B4GALNT2 -831.0
COMMD1 -834.0
EEF2KMT -846.0
BET1L -856.0
KDELR1 -858.0
BMP4 -863.0
H2AC20 -868.0
ETFBKMT -881.0
LYPD6B -952.0
PML -953.0
ING2 -960.0
L3MBTL2 -961.0
BTBD6 -966.0
NUP153 -967.0
SEM1 -983.0
CUL2 -986.0
PSMB3 -999.0
TMED2 -1004.0
VDAC1 -1006.0
FOXL2 -1009.0
H2BC21 -1063.0
IDE -1067.0
RAB40C -1103.0
FBXL5 -1132.0
LMO7 -1153.0
INO80C -1187.0
B3GNT6 -1196.0
PEX2 -1226.0
H2BC17 -1228.0
NUP188 -1240.0
TTL -1242.0
AFP -1254.0
ARCN1 -1259.0
SATB1 -1265.0
H2AC21 -1268.0
FBXL20 -1279.0
CNTN5 -1299.0
NUP85 -1309.0
NEU1 -1321.0
ADAMTS2 -1338.0
FBXO10 -1342.0
FOXK1 -1349.0
COPB2 -1367.0
RAD23B -1385.0
ARFGAP3 -1389.0
GALNT1 -1395.0
DCAF16 -1399.0
SERPINA10 -1440.0
F5 -1445.0
H2BC5 -1467.0
EEF1AKMT1 -1469.0
LRRC49 -1483.0
TADA3 -1487.0
NPL -1492.0
CD109 -1515.0
PTEN -1517.0
ADAMTS17 -1519.0
GCNT7 -1525.0
ST6GALNAC5 -1529.0
RPS27A -1533.0
TRIM28 -1565.0
H2BC8 -1568.0
TNIP1 -1571.0
STX5 -1574.0
ASB2 -1585.0
BABAM1 -1603.0
NFKBIA -1622.0
VHL -1641.0
H2AC16 -1673.0
USP3 -1689.0
AGBL4 -1691.0
TUBA8 -1700.0
RPA1 -1712.0
ARFGAP2 -1734.0
SEC23IP -1755.0
RAB4A -1771.0
NTNG1 -1790.0
NANS -1793.0
SEC24D -1860.0
DCUN1D2 -1900.0
IGFBP3 -1914.0
INO80E -1929.0
VCPKMT -1942.0
MUC15 -1950.0
GALNT17 -1963.0
CMAS -2008.0
MUL1 -2029.0
RNF144A -2036.0
FBXO15 -2065.0
NUP107 -2066.0
PIGX -2068.0
FBXO6 -2111.0
CTR9 -2112.0
SENP2 -2121.0
ALG6 -2127.0
PEX5 -2154.0
OTUD7B -2201.0
SUDS3 -2206.0
USP44 -2236.0
TECTA -2237.0
UBE2T -2243.0
ASB10 -2245.0
HERC2 -2249.0
PSMB4 -2273.0
PSMB11 -2276.0
B3GNT4 -2279.0
HLA-A -2281.0
THSD4 -2313.0
ULBP2 -2334.0
SENP1 -2358.0
TUBB2B -2381.0
GALNT3 -2428.0
RAB19 -2435.0
TRAPPC2L -2455.0
KTN1 -2481.0
NCOA2 -2483.0
GALNT16 -2500.0
USP34 -2502.0
FBXL7 -2517.0
VCPIP1 -2519.0
UHRF2 -2548.0
AMTN -2561.0
FBXL22 -2601.0
CALM1 -2630.0
ST3GAL6 -2635.0
ST8SIA1 -2645.0
H2BC1 -2654.0
LMAN1 -2662.0
MBD5 -2667.0
ADAMTS12 -2671.0
RAB40B -2694.0
RORA -2741.0
ASB13 -2764.0
LYPD8 -2766.0
ST8SIA5 -2770.0
TTLL7 -2773.0
ACTR8 -2780.0
MUC21 -2791.0
SEC24C -2804.0
NR1H4 -2811.0
ASXL2 -2821.0
ATXN7 -2833.0
RELA -2850.0
PIGT -2858.0
MVD -2861.0
BAP1 -2897.0
UBE2G2 -2907.0
TNC -2937.0
TMED9 -2938.0
SPTB -2943.0
CHGB -2945.0
SPP2 -2958.0
PSMD13 -2965.0
RAB5C -2970.0
TECTB -2978.0
UBE2E1 -2989.0
GOSR2 -3018.0
STX17 -3029.0
RAB11B -3033.0
NPLOC4 -3046.0
CTSC -3049.0
PIGP -3057.0
TDG -3101.0
CCDC8 -3115.0
RAB25 -3127.0
TNKS -3129.0
ADAMTS18 -3137.0
NUP54 -3157.0
QSOX1 -3166.0
TTLL12 -3175.0
TTLL10 -3195.0
ASB4 -3216.0
MGAT4C -3233.0
DPAGT1 -3237.0
OPCML -3239.0
AGTPBP1 -3259.0
GALNT4 -3264.0
FBXL16 -3271.0
ASB18 -3276.0
FBXL13 -3285.0
PIGZ -3287.0
DDX5 -3289.0
EDEM2 -3294.0
TMED10 -3307.0
GFPT2 -3329.0
ELOC -3332.0
NR2C1 -3335.0
RABGGTA -3337.0
THSD7B -3368.0
NEGR1 -3371.0
ASB7 -3382.0
AURKB -3399.0
PSMD5 -3403.0
UBE2V2 -3410.0
DCTN5 -3434.0
PSMC5 -3453.0
ICMT -3466.0
RAB11A -3477.0
PCNA -3500.0
MAT2B -3508.0
PHC2 -3516.0
TOMM70 -3528.0
PIGU -3534.0
DPM2 -3545.0
UBXN1 -3556.0
TUBA4A -3571.0
SYVN1 -3589.0
IGFBP5 -3598.0
METTL22 -3655.0
SOCS2 -3674.0
RAB33B -3676.0
UBD -3682.0
COPS8 -3698.0
ADRB2 -3715.0
NFKB2 -3725.0
TRRAP -3741.0
SEMA5B -3745.0
H4C13 -3757.0
PRKDC -3761.0
APC -3771.0
ANK2 -3774.0
COG7 -3816.0
MDC1 -3823.0
TGFBR2 -3831.0
GALNT9 -3832.0
NRN1 -3837.0
BLM -3849.0
METTL21A -3861.0
UBE2D1 -3868.0
H2AC17 -3931.0
FBXL19 -3932.0
FUOM -3949.0
ANO8 -3992.0
CUL1 -3995.0
TRAPPC6A -3996.0
TRIM25 -3997.0
DCTN4 -4001.0
H4C12 -4032.0
DHDDS -4035.0
H2AC1 -4057.0
BET1 -4065.0
PRKN -4079.0
NUP42 -4112.0
GBF1 -4144.0
TOP2A -4160.0
CP -4173.0
TTLL6 -4183.0
NANP -4202.0
RNF2 -4210.0
GALNT6 -4221.0
ETFB -4235.0
BTBD1 -4237.0
CDC34 -4251.0
PRSS21 -4258.0
MEN1 -4264.0
COPZ1 -4289.0
COPS7B -4290.0
RNF181 -4293.0
ADAMTSL5 -4301.0
GNPNAT1 -4306.0
FBXO31 -4326.0
PHC1 -4338.0
PSMD4 -4342.0
INCENP -4343.0
APOA2 -4355.0
CREBBP -4376.0
UCHL1 -4392.0
IGFBP1 -4393.0
H4C11 -4396.0
ADAMTSL3 -4400.0
LTBP1 -4402.0
ADAMTS13 -4407.0
KEAP1 -4410.0
FUT3 -4414.0
CHST8 -4415.0
PSMB9 -4444.0
TTLL1 -4448.0
ARSJ -4453.0
UBE2J2 -4459.0
LAMB1 -4481.0
NUP133 -4485.0
GORASP1 -4494.0
ENGASE -4520.0
MGAT3 -4529.0
RAB31 -4536.0
TNIP2 -4566.0
SEMA5A -4598.0
ASXL1 -4603.0
AMBN -4667.0
PROC -4715.0
BTRC -4751.0
COPS7A -4754.0
COPS2 -4757.0
FBXO21 -4779.0
SUMO1 -4803.0
PENK -4814.0
PROZ -4825.0
EIF5A -4852.0
FBXO9 -4853.0
EP300 -4863.0
CAPZB -4876.0
TBC1D20 -4889.0
FPGT -4922.0
H4C2 -4924.0
PUM2 -4925.0
B4GALT6 -4947.0
RAB3D -4950.0
CSF1 -4973.0
ACTL6A -4981.0
RAB26 -5028.0
AURKA -5029.0
FBXW11 -5045.0
WSB1 -5104.0
RAB3C -5109.0
TFPT -5128.0
CST3 -5207.0
ALG1 -5275.0
H2AC11 -5298.0
LSAMP -5305.0
NUP205 -5309.0
FUCA1 -5331.0
KLHL2 -5346.0
MITF -5358.0
PSME2 -5360.0
H2AC18 -5374.5
H2AC19 -5374.5
NR1H2 -5389.0
USP25 -5425.0
NUP37 -5465.0
COG2 -5474.0
BARD1 -5487.0
USP4 -5518.0
DDX17 -5523.0
DOLPP1 -5570.0
LYPD5 -5577.0
UBE2I -5588.0
USO1 -5597.0
TMED7 -5603.0
FSTL3 -5650.0
TOMM20 -5667.0
TTLL8 -5680.0
ASGR1 -5692.0
DYNLL1 -5706.0
GCNT4 -5736.0
AGBL1 -5758.0
COPZ2 -5774.0
UBA52 -5785.0
EEF2 -5806.0
AMDHD2 -5828.0
NAE1 -5837.0
JOSD2 -5846.0
CAMKMT -5877.0
BIRC5 -5921.0
FBXL8 -5927.0
FGF23 -5931.0
FAM20C -5985.0
CUL7 -6006.0
YKT6 -6023.0
RAB42 -6027.0
SIN3A -6036.0
GALNTL5 -6047.0
GLB1 -6060.0
TRIM27 -6062.0
PSMB8 -6074.0
WDR48 -6081.0
FKBP8 -6098.0
ADAMTS16 -6102.0
ACTR1A -6110.0
COPG2 -6124.0
ANK3 -6134.0
ITIH2 -6141.0
VNN1 -6164.0
VCP -6166.0
DPH1 -6171.0
B4GALT2 -6213.0
RXRA -6219.0
FBXL14 -6234.0
PSMD1 -6278.0
DNMT1 -6281.0
SERPINC1 -6285.0
ANK1 -6296.0
ASB5 -6299.0
XPC -6305.0
LARGE1 -6321.0
CNIH3 -6324.0
UBC -6330.0
IGFBP7 -6339.0
LARGE2 -6350.0
PSMD11 -6358.0
STAMBP -6378.0
SPARCL1 -6382.0
RAB35 -6386.0
PMM2 -6395.0
SAR1B -6436.0
H2AC8 -6437.0
DERL2 -6446.0
MAN1B1 -6447.0
RWDD3 -6452.0
GALNT14 -6457.0
H2BC10 -6470.0
UAP1 -6487.0
ASB6 -6496.0
ALG3 -6502.0
MUC12 -6514.0
C1GALT1 -6530.0
PCSK9 -6532.0
NAGK -6534.0
TGOLN2 -6539.0
GCNT1 -6541.0
NR5A1 -6576.0
KIN -6598.0
DAG1 -6612.0
TUBB6 -6632.0
DCUN1D3 -6633.0
FUT8 -6650.0
THSD7A -6651.0
KLHL41 -6661.0
BIRC3 -6662.0
FGA -6725.0
F10 -6729.0
TPR -6736.0
TRAF2 -6761.0
PSMC4 -6772.0
UBA3 -6778.0
HGS -6788.0
SPSB4 -6800.0
COMMD9 -6827.0
TTLL4 -6857.0
EID3 -6878.0
NUS1 -6879.0
ADAMTSL2 -6880.0
UBE2S -6896.0
RAB23 -6932.0
ST8SIA6 -6969.0
PSMB10 -6982.0
THSD1 -6986.0
RAB1B -6991.0
VDAC2 -6995.0
APOL1 -7009.0
TTLL11 -7012.0
GALNT18 -7050.0
KLHL11 -7075.0
RCN1 -7096.0
USP14 -7103.0
DAD1 -7148.0
RAB6B -7150.0
SUMO3 -7184.0
TUBA4B -7208.0
TMEM129 -7246.0
FN3KRP -7260.0
UBE2Z -7287.0
PSMD2 -7294.0
LRR1 -7306.0
TMEM132A -7310.0
MUC1 -7326.0
DPM3 -7362.0
COPS3 -7365.0
B3GNTL1 -7366.0
SPTBN2 -7373.0
RTN4RL2 -7380.0
PSMD8 -7400.0
USP8 -7422.0
BPIFB2 -7424.0
RAB3B -7439.0
FCSK -7447.0
ADAMTS14 -7454.0
PSMA2 -7473.0
ALPI -7493.0
HIC1 -7499.0
RBX1 -7501.0
ALG5 -7531.0
TUBA1B -7561.0
RAB44 -7564.0
HSP90B1 -7565.0
CFTR -7584.0
RANBP2 -7590.0
SUMO2 -7598.0
PTP4A2 -7605.0
CALU -7639.0
KNG1 -7691.0
THY1 -7694.0
RAB43 -7716.0
IL33 -7740.0
NEU3 -7749.0
MUC3A -7780.0
CCNA2 -7800.0
DCUN1D4 -7807.0
ESR1 -7821.0
FGG -7833.0
MDGA1 -7841.0
NDC1 -7862.0
NEDD8 -7872.0
H2BC3 -7881.0
LRRC41 -7887.0
LYPD2 -7892.0
GALNT5 -7929.0
NR4A2 -7931.0
TPGS1 -7942.0
SCG3 -7958.0
RPN1 -7960.0
SEC13 -7989.0
MUC4 -8031.0
FBXL3 -8034.0
MBD1 -8066.0
PSMD3 -8072.0
NUCB1 -8098.0
UBE2D2 -8120.0
WDR5 -8127.0
SHISA5 -8157.0
ASB1 -8162.0
DCTN6 -8184.0
LMAN1L -8189.0
PEX12 -8218.0
ARFGAP1 -8240.0
RTN4RL1 -8260.0
COPS4 -8264.0
RAB4B -8281.0
H2BC11 -8289.0
COPE -8298.0
PPP6R1 -8303.0
ABRAXAS1 -8340.0
GCNT3 -8355.0
NEU4 -8385.0
ARRB2 -8388.0
DHPS -8409.0
MANEA -8410.0
PSME1 -8414.0
HDAC7 -8439.0
ART4 -8486.0
APOA5 -8501.0
MUC16 -8512.0
PROS1 -8518.0
PSMD9 -8531.0
GPLD1 -8535.0
ASB15 -8563.0
SPSB2 -8573.0
MGAT2 -8582.5
SEC22C -8630.0
FBXO17 -8688.0
SKP2 -8702.0
ALG2 -8716.0
ABRAXAS2 -8753.0
GPS1 -8787.0
UBE2C -8798.0
THBS2 -8841.0
UCHL5 -8847.0
CUL5 -8880.0
COG6 -8930.0
NSMCE4A -8942.0
TUBA3C -8978.0
B4GAT1 -8985.0
SEC24A -8999.0
RAD23A -9010.0
FBXO30 -9025.0
RAB27B -9059.0
FBXO32 -9081.0
TEX101 -9110.0
ADAMTS15 -9116.0
ARF5 -9166.0
PPP6C -9186.0
TTLL9 -9217.0
FN1 -9234.0
OTUB1 -9244.0
NOP58 -9254.0
AHSG -9290.0
RNF146 -9319.0
PAF1 -9326.0
TUBB3 -9409.0
PIAS4 -9417.0
ADRM1 -9464.0
ALG12 -9530.0
PMM1 -9559.0
USP16 -9581.0
UMOD -9618.0
MUC5B -9660.0
ADAMTS4 -9663.0
STT3A -9692.0
ACTR5 -9762.0
OTOA -9797.0
POM121 -9839.0
RAB36 -9855.0
WFS1 -9868.0
ARF4 -9892.0
RAB1A -9914.0
SKIC8 -9920.0
KLHL9 -9931.0
UBE2N -9943.0
TUBA1C -9991.0
SOCS3 -9994.0
ASGR2 -10001.0
MOGS -10014.0
PIAS3 -10029.0
FBXW9 -10051.0
ERCC8 -10092.0
GALNT15 -10094.0
NEU2 -10133.0
COG1 -10164.0
ALG8 -10189.0
DCTN3 -10196.0
MAN1A2 -10267.0
EIF5A2 -10270.0
NICN1 -10280.0
ALPG -10408.0
SUMF1 -10459.0
PSMC2 -10548.0
UBE2M -10559.0
RNF20 -10570.0
PDIA3 -10574.0
COPS6 -10624.0
SPACA4 -10715.0
RPS2 -10734.0
AGBL2 -10749.0
LY6D -10811.0
TUBA3E -10852.0
H2BC9 -10890.5
FBXW10 -10899.0
GP2 -10919.0
NUDT14 -10972.0
FEM1A -11014.0
BECN1 -11075.0
TTLL2 -11335.0
CEACAM7 -11349.0
FOLR1 -11363.0
RAET1L -11405.0
TUBB8 -11501.0
FCGR3B -11650.0


REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS
216
set REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS
setSize 14
pANOVA 0.00196
s.dist -0.478
p.adjustANOVA 0.489



Top enriched genes

Top 20 genes
GeneID Gene Rank
C1QA -10847
FCN3 -10790
MBL2 -10523
CRP -9789
COLEC10 -9678
FCN2 -9436
MASP2 -8568
MASP1 -6820
COLEC11 -6542
C1S -5156
C1QC -4515
C1QB -2895
C1R 4269
FCN1 8161

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C1QA -10847
FCN3 -10790
MBL2 -10523
CRP -9789
COLEC10 -9678
FCN2 -9436
MASP2 -8568
MASP1 -6820
COLEC11 -6542
C1S -5156
C1QC -4515
C1QB -2895
C1R 4269
FCN1 8161


REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
1082
set REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
setSize 125
pANOVA 0.00209
s.dist -0.159
p.adjustANOVA 0.489



Top enriched genes

Top 20 genes
GeneID Gene Rank
KRT6C -11517
KRT79 -11437
KRT16 -11412
LCE5A -11389
KRT39 -11284
KRT17 -11185
LCE4A -11061
KRT78 -10976
KRT38 -10925
KLK12 -10888
LCE2B -10863
KRT4 -10842
CASP14 -10761
KRT5 -10614
KRT75 -10565
KRT25 -10428
PKP1 -10350
KRT80 -10325
DSG2 -10146
EVPL -10113

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KRT6C -11517
KRT79 -11437
KRT16 -11412
LCE5A -11389
KRT39 -11284
KRT17 -11185
LCE4A -11061
KRT78 -10976
KRT38 -10925
KLK12 -10888
LCE2B -10863
KRT4 -10842
CASP14 -10761
KRT5 -10614
KRT75 -10565
KRT25 -10428
PKP1 -10350
KRT80 -10325
DSG2 -10146
EVPL -10113
KRT37 -10109
KRT83 -10083
LIPJ -10056
KRT86 -10047
LIPM -9936
SPINK5 -9883
CELA2A -9874
SPRR1B -9842
SPINK9 -9834
KRT14 -9799
SPRR2F -9733
KRT2 -9702
DSG1 -9621
FLG -9599
TGM1 -9596
LCE3D -9499
KRT82 -9393
KRT71 -9076
KLK14 -8900
KRT3 -8670
CDSN -8661
JUP -8506
KLK5 -8354
KAZN -7425
KLK8 -7330
KRT13 -7255
KRT76 -7251
RPTN -6883
DSG4 -6781
KRT18 -6776
PI3 -6732
KRT32 -6566
KRT33A -6484
LCE2D -6469
KRT84 -5988
KRT74 -5966
PPL -5531
PKP2 -5502
CSTA -5383
CAPN1 -5221
KRT23 -5070
KRT34 -4951
ST14 -4909
KRT36 -4245
KRT35 -3235
LCE3B -3153
LCE6A -2693
KRT7 -2454
LCE2A -2301
KRT85 -1481
CAPNS1 -1446
IVL -1361
PCSK6 -1098
SPRR2D -1056
PRSS8 -1049
KRT19 -660
SPRR3 -407
DSC2 -354
KRT9 -14
LIPN 291
PKP3 656
KRT24 908
LCE1C 972
KRT1 989
PERP 1670
KRT10 2442
KRT26 2881
LCE1B 2917
TGM5 3557
KRT31 3560
TCHH 4025
LCE3E 4139
PKP4 4187
KRT12 4254
LCE3A 4367
DSC3 4690
KRT33B 5197
KRT77 5400
KRT40 5835
SPRR2A 6211
KRT8 6495
KRT28 6578
SPRR2G 6836
KLK13 7183
LIPK 7336
KRT27 7558
DSG3 7772
FURIN 7787
KRT81 7903
DSP 8196
KRT72 8579
KRT15 8592
KRT20 9017
KRT6A 9166
SPRR1A 9180
SPINK6 9181
LELP1 9365
KRT73 9451
LCE2C 9511
LCE1E 9636
SPRR2E 9711
DSC1 9768
KRT6B 9885
LCE1A 10083
LCE1F 10206


REACTOME_RAC3_GTPASE_CYCLE

REACTOME_RAC3_GTPASE_CYCLE
1382
set REACTOME_RAC3_GTPASE_CYCLE
setSize 85
pANOVA 0.00308
s.dist 0.186
p.adjustANOVA 0.557



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARHGAP1 8901
ITGB1 8797
GIT2 8464
ARHGAP26 8399
GIT1 8353
LBR 8124
DEPDC1B 8107
TFRC 8027
ABL2 7657
RAB7A 7589
ARHGDIB 7571
WASF1 7373
STBD1 7364
BAIAP2L1 7212
VANGL1 7202
NOXO1 7088
WASF2 6701
ABI1 6546
ARHGAP15 6165
SNAP23 6134

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARHGAP1 8901
ITGB1 8797
GIT2 8464
ARHGAP26 8399
GIT1 8353
LBR 8124
DEPDC1B 8107
TFRC 8027
ABL2 7657
RAB7A 7589
ARHGDIB 7571
WASF1 7373
STBD1 7364
BAIAP2L1 7212
VANGL1 7202
NOXO1 7088
WASF2 6701
ABI1 6546
ARHGAP15 6165
SNAP23 6134
RAPGEF1 5691
SLITRK3 5549
BCR 5509
PIK3R1 5095
PREX1 5055
NCKAP1 4923
LAMTOR1 4874
PIK3R2 4716
SWAP70 4546
FERMT2 4333
TIAM1 4159
NOX3 3932
SYDE1 3876
SRGAP2 3805
PGRMC2 3722
TRIO 3681
ARAP2 3625
RACGAP1 3131
NOXA1 2824
TAOK3 2763
PAK4 2215
ARHGAP17 2177
ARAP3 1813
NCKAP1L 1771
RAC3 1628
SLITRK5 1614
CDC42EP1 1468
MPP7 1355
VAV2 1201
DOCK10 820
ARHGAP35 545
ABI2 413
PAK1 195
VAMP3 -30
ARHGAP21 -164
NCF4 -285
ARHGAP32 -327
ESYT1 -399
DIAPH3 -451
VRK2 -645
MCAM -821
CYBA -886
AMIGO2 -1752
ABR -1934
LMAN1 -2662
NCF2 -3009
SLC1A5 -4061
PAK2 -4190
BAIAP2 -4622
LEMD3 -4795
CDC42 -4898
IL32 -5052
CYFIP1 -5069
ERBIN -5182
ARHGAP42 -5489
YKT6 -6023
EPHA2 -6044
JAG1 -6764
CAV1 -6920
ARHGAP5 -8324
ARHGAP39 -9188
TMPO -9513
BRK1 -9918
DSG2 -10146
GARRE1 -10188


REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX
115
set REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX
setSize 134
pANOVA 0.00337
s.dist -0.147
p.adjustANOVA 0.557



Top enriched genes

Top 20 genes
GeneID Gene Rank
CMA1 -11344
CTRB2 -11288
MMP7 -11156
PLG -10695
KLK7 -10584
CTRB1 -10554
CTSV -10437
CAPN5 -10177
MMP12 -10114
COL5A1 -10063
CAPN13 -10017
OPTC -9771
CTSB -9687
MMP20 -9667
ADAMTS4 -9663
MMP14 -9479
MMP16 -9444
MMP3 -9382
ADAM15 -9250
FN1 -9234

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CMA1 -11344
CTRB2 -11288
MMP7 -11156
PLG -10695
KLK7 -10584
CTRB1 -10554
CTSV -10437
CAPN5 -10177
MMP12 -10114
COL5A1 -10063
CAPN13 -10017
OPTC -9771
CTSB -9687
MMP20 -9667
ADAMTS4 -9663
MMP14 -9479
MMP16 -9444
MMP3 -9382
ADAM15 -9250
FN1 -9234
COL10A1 -9142
CTSL -9042
BMP1 -9040
COL11A1 -8736
PRSS1 -8713
CAPN11 -8589
MMP11 -8464
COL5A3 -8320
SCUBE1 -8297
COL6A3 -8192
ELANE -7993
MMP17 -7975
COL17A1 -7891
HSPG2 -7846
SCUBE3 -7809
CTSD -7796
CTSG -7778
COL8A2 -7496
COL6A5 -7434
COL12A1 -7141
CAPN3 -7093
COL18A1 -7044
COL26A1 -6836
COL6A6 -6755
MMP24 -6677
COL13A1 -6600
COL16A1 -6417
ADAMTS16 -6102
CAPN10 -5892
PHYKPL -5833
KLKB1 -5810
TIMP2 -5285
CAPN1 -5221
SPOCK3 -5171
MMP2 -5141
COL4A3 -5125
LAMA3 -5047
BSG -4804
LAMB1 -4481
COL11A2 -4360
COL1A1 -3656
CAPN9 -3651
HTRA1 -3412
LAMB3 -3408
NCSTN -3226
ADAMTS18 -3137
MMP25 -3008
FBN3 -2944
COL3A1 -2892
ACAN -2354
DCN -1982
COL23A1 -1765
LAMC2 -1573
CAPNS1 -1446
CAPNS2 -1360
LAMA5 -1145
COL9A3 -1139
COL25A1 -1089
ELN -1055
CDH1 -937
COL4A2 -576
A2M -395
COL1A2 -289
CAST -222
TLL2 -188
MMP13 326
COL5A2 337
COL9A2 366
COL4A1 435
PSEN1 596
KLK2 848
BCAN 889
ADAM10 1018
MMP9 1503
COL19A1 1799
CAPN15 1996
CAPN8 2397
SPP1 2404
NID1 2615
ADAMTS9 2779
MMP19 3121
ADAMTS8 3141
ADAM17 3251
CAPN2 3312
COL6A1 3747
MMP15 3752
COL6A2 4075
MMP10 4123
CD44 4518
FBN1 4614
LAMC1 4715
FBN2 4949
COL4A4 5163
CAPN12 5242
CASP3 6002
ADAMTS1 6110
ADAM8 6113
TLL1 6205
COL15A1 6283
COL9A1 6648
COL14A1 6959
CAPN7 7002
ADAM9 7058
MMP1 7081
TMPRSS6 7119
CTSK 7136
CAPN14 7270
COL2A1 7578
COL8A1 7682
COL7A1 7748
FURIN 7787
ADAMTS5 7943
CTSS 8308
MMP8 9887


REACTOME_LEISHMANIA_INFECTION

REACTOME_LEISHMANIA_INFECTION
1509
set REACTOME_LEISHMANIA_INFECTION
setSize 156
pANOVA 0.00339
s.dist 0.136
p.adjustANOVA 0.557



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGR 9943
GNGT2 9520
GNG2 9409
FCGR2A 9160
CYSLTR2 8858
IL10 8662
FCGR3A 8638
APP 8327
GNG8 8220
DPEP3 8189
GNG11 8135
SUGT1 7888
LYN 7833
C3AR1 7790
FURIN 7787
DPEP2 7605
C3 7498
MAPK1 7485
WASF1 7373
WIPF1 7326

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGR 9943
GNGT2 9520
GNG2 9409
FCGR2A 9160
CYSLTR2 8858
IL10 8662
FCGR3A 8638
APP 8327
GNG8 8220
DPEP3 8189
GNG11 8135
SUGT1 7888
LYN 7833
C3AR1 7790
FURIN 7787
DPEP2 7605
C3 7498
MAPK1 7485
WASF1 7373
WIPF1 7326
NT5E 7103
NOXO1 7088
NLRP3 7029
IL1A 7015
YES1 6879
TXN 6870
ADCY3 6766
ELMO1 6713
WASF2 6701
IL18 6674
DVL1 6571
ABI1 6546
FYN 6383
GNAS 6225
ACTB 6159
NCKIPSD 6065
PRKACG 5903
IL6 5855
MYO5A 5838
ARPC3 5633
MAPK14 5500
ENTPD5 5318
GGT1 5171
MYO9B 5064
NFKB1 5042
VAV3 5004
WNT5A 4954
NCKAP1 4923
ITPR1 4603
GRB2 4512
ITPR2 4458
PTK2 4381
PRKAR1A 4152
GNAI1 4024
GNG13 4000
HSP90AB1 3800
IL1B 3779
ABL1 3708
PRKACB 3366
JUN 3276
ADAM17 3251
ADCY7 3216
GNB3 3205
SYK 3145
VAV1 2933
P2RX4 2852
NOXA1 2824
MYO1C 2747
ADCY9 2707
HCK 2444
ACTR3 2437
ADCY8 2346
GNB4 2294
ENTPD1 2181
NCKAP1L 1771
GNAI2 1483
GNG4 1353
PRKAR2B 1351
ARPC1B 1241
GNG3 1215
VAV2 1201
GGT5 1001
ELMO2 863
GNG5 843
ACTR2 660
ABI2 413
CYFIP2 267
DPEP1 198
NCK1 121
CD3G -153
ARPC1A -344
PSTPIP1 -569
TXNIP -592
CRK -627
GSDMD -744
CYBA -886
FZD7 -938
CREB1 -1008
RHBDF2 -1062
WIPF3 -1280
ARPC4 -1377
PLK2 -1883
MYH2 -2103
GNB2 -2299
RAC1 -2405
PYCARD -2515
CALM1 -2630
GNG12 -2742
RELA -2850
ARPC2 -2899
ADCY1 -2954
GNG7 -3023
MAPK3 -3148
GNB5 -3181
PRKACA -3304
DOCK1 -3369
CD247 -3468
NFKB2 -3725
ADORA2B -3815
ITPR3 -4089
MYH9 -4157
WIPF2 -4181
ADCY4 -4379
WASL -4607
BAIAP2 -4622
PRKAR1B -4706
PLCG1 -4734
CDC42 -4898
CD163 -5020
GNAI3 -5056
CYFIP1 -5069
ADCY2 -5332
WASF3 -5486
GNB1 -5542
ACTG1 -5857
GNG10 -5937
PLCG2 -6033
SRC -6713
ADCY5 -6975
ARPC5 -7230
MAPK8 -7474
AHCYL1 -7514
CTSG -7778
MYO10 -7921
CASP1 -7968
PRKAR2A -8009
GNAZ -8405
P2RX7 -8541
DVL2 -8584
GNGT1 -9287
ADCY6 -9314
DVL3 -9398
HMOX1 -9434
MEFV -9478
BRK1 -9918
GNAT3 -10495


REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS
1640
set REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS
setSize 28
pANOVA 0.00487
s.dist 0.307
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
CD22 9937
CD79A 9546
CD79B 9354
CD19 8561
PTPN6 8056
LYN 7833
BLNK 6992
FYN 6383
STIM1 5364
PIK3R1 5095
SOS1 4943
ITPR1 4603
GRB2 4512
ITPR2 4458
ORAI1 3927
BLK 3811
SYK 3145
VAV1 2933
DAPP1 2919
PIK3AP1 257

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CD22 9937
CD79A 9546
CD79B 9354
CD19 8561
PTPN6 8056
LYN 7833
BLNK 6992
FYN 6383
STIM1 5364
PIK3R1 5095
SOS1 4943
ITPR1 4603
GRB2 4512
ITPR2 4458
ORAI1 3927
BLK 3811
SYK 3145
VAV1 2933
DAPP1 2919
PIK3AP1 257
NCK1 121
PIK3CD -1420
CALM1 -2630
ITPR3 -4089
PLCG2 -6033
AHCYL1 -7514
TRPC1 -7597
ORAI2 -7977


REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION
520
set REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION
setSize 16
pANOVA 0.00598
s.dist 0.397
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
PDPK1 9029
LYN 7833
SHC1 7154
FCER1G 6792
FYN 6383
PIK3R1 5095
FCER1A 4946
SOS1 4943
PIK3R2 4716
GRB2 4512
SYK 3145
PIK3CB 2088
GAB2 1348
LAT2 507
PIK3CA 239
MS4A2 -9821

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PDPK1 9029
LYN 7833
SHC1 7154
FCER1G 6792
FYN 6383
PIK3R1 5095
FCER1A 4946
SOS1 4943
PIK3R2 4716
GRB2 4512
SYK 3145
PIK3CB 2088
GAB2 1348
LAT2 507
PIK3CA 239
MS4A2 -9821


REACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS

REACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS
1220
set REACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS
setSize 5
pANOVA 0.00656
s.dist 0.702
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
DHRS7B 9170
GNPAT 7715
AGPS 6572
FAR1 6402
FAR2 5339

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DHRS7B 9170
GNPAT 7715
AGPS 6572
FAR1 6402
FAR2 5339


REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION

REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION
213
set REACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION
setSize 8
pANOVA 0.00667
s.dist -0.554
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FCN3 -10790
MBL2 -10523
COLEC10 -9678
FCN2 -9436
MASP2 -8568
MASP1 -6820
COLEC11 -6542
FCN1 8161

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FCN3 -10790
MBL2 -10523
COLEC10 -9678
FCN2 -9436
MASP2 -8568
MASP1 -6820
COLEC11 -6542
FCN1 8161


REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT
214
set REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT
setSize 21
pANOVA 0.00693
s.dist -0.34
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
C1QA -10847.0
FCN3 -10790.0
MBL2 -10523.0
CRP -9789.0
COLEC10 -9678.0
GZMM -9631.0
FCN2 -9436.0
MASP2 -8568.0
CFB -8442.0
MASP1 -6820.0
C2 -6643.0
COLEC11 -6542.0
C1S -5156.0
C1QC -4515.0
CFD -3258.0
C1QB -2895.0
C1R 4269.0
C4A 5353.5
C4B 5353.5
C3 7498.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C1QA -10847.0
FCN3 -10790.0
MBL2 -10523.0
CRP -9789.0
COLEC10 -9678.0
GZMM -9631.0
FCN2 -9436.0
MASP2 -8568.0
CFB -8442.0
MASP1 -6820.0
C2 -6643.0
COLEC11 -6542.0
C1S -5156.0
C1QC -4515.0
CFD -3258.0
C1QB -2895.0
C1R 4269.0
C4A 5353.5
C4B 5353.5
C3 7498.0
FCN1 8161.0


REACTOME_FERTILIZATION

REACTOME_FERTILIZATION
53
set REACTOME_FERTILIZATION
setSize 26
pANOVA 0.0072
s.dist -0.304
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACR -11330
CATSPER3 -11275
OVGP1 -10920
ADAM2 -10455
CATSPER1 -10324
IZUMO2 -9904
ZP3 -9403
ZP4 -9291
ADAM21 -8872
CATSPERB -8434
CATSPERG -8155
CATSPERD -7420
ZP2 -7056
HVCN1 -6507
IZUMO4 -6482
SPAM1 -5213
CATSPER2 -5167
ZP1 -4277
ADAM30 3214
IZUMO1 4579

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACR -11330
CATSPER3 -11275
OVGP1 -10920
ADAM2 -10455
CATSPER1 -10324
IZUMO2 -9904
ZP3 -9403
ZP4 -9291
ADAM21 -8872
CATSPERB -8434
CATSPERG -8155
CATSPERD -7420
ZP2 -7056
HVCN1 -6507
IZUMO4 -6482
SPAM1 -5213
CATSPER2 -5167
ZP1 -4277
ADAM30 3214
IZUMO1 4579
B4GALT1 4941
ADAM20 5085
KCNU1 5258
CATSPER4 5591
CD9 6820
IZUMO3 10260


REACTOME_BASE_EXCISION_REPAIR

REACTOME_BASE_EXCISION_REPAIR
1164
set REACTOME_BASE_EXCISION_REPAIR
setSize 87
pANOVA 0.00955
s.dist 0.161
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
ADPRS 9895
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
H2AC4 8927
H2BC4 8612
H2BC12 8544
POLB 8304
APEX1 8290
H2AC6 8154
H2BC15 7521
H2AJ 7388
H4C16 7045
H2BC13 6942
POT1 6924
MPG 6840
RPA3 6839

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
ADPRS 9895.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
POLB 8304.0
APEX1 8290.0
H2AC6 8154.0
H2BC15 7521.0
H2AJ 7388.0
H4C16 7045.0
H2BC13 6942.0
POT1 6924.0
MPG 6840.0
RPA3 6839.0
TERF2 6539.0
FEN1 6533.0
POLE3 6416.0
LIG1 6203.0
H4C8 6011.0
TERF1 5383.0
RFC1 5369.0
PARP2 5059.0
NTHL1 5038.0
POLE4 4855.0
H4C3 4600.0
OGG1 4533.0
XRCC1 4510.0
MUTYH 4103.0
H4C4 3780.0
H2BC26 3341.0
NEIL1 3198.0
POLD4 2987.0
H4C1 2954.0
H2AZ2 2797.0
POLD2 2520.0
NEIL2 1658.0
NEIL3 1535.0
RFC2 1255.0
H2AC7 427.5
H2BC7 427.5
POLE 310.0
UNG 222.0
PARP1 99.0
MBD4 52.0
POLE2 -50.0
H3-4 -176.0
H2AC20 -868.0
H2BC21 -1063.0
RFC4 -1101.0
H2BC17 -1228.0
H2BC5 -1467.0
H2BC8 -1568.0
RPA1 -1712.0
ACD -2576.5
H2BC1 -2654.0
TERF2IP -2690.0
TDG -3101.0
PCNA -3500.0
H4C13 -3757.0
H4C12 -4032.0
POLD1 -4297.0
H4C11 -4396.0
RFC5 -4495.0
PNKP -4741.0
H4C2 -4924.0
H2AC18 -5374.5
H2AC19 -5374.5
POLD3 -6198.0
H2AC8 -6437.0
H2BC10 -6470.0
LIG3 -6509.0
H2AZ1 -7039.0
TINF2 -7736.0
RPA2 -7797.0
H2BC3 -7881.0
SMUG1 -8121.0
H2BC11 -8289.0
RFC3 -8673.0
H2AX -9438.0
PARG -9475.0
H2BC9 -10890.5


REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE

REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE
1025
set REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE
setSize 66
pANOVA 0.0102
s.dist 0.183
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
CENPW 9794
H4C9 9566
H4C5 9308
ITGB3BP 9201
H4C6 9192
H2BC14 9173
H2AC4 8927
H2BC4 8612
H2BC12 8544
MIS18BP1 8533
H2AC6 8154
H2BC15 7521
H2AJ 7388
H4C16 7045
H2BC13 6942
RUVBL1 6916
OIP5 6752
NPM1 6135

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
CENPW 9794.0
H4C9 9566.0
H4C5 9308.0
ITGB3BP 9201.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
MIS18BP1 8533.0
H2AC6 8154.0
H2BC15 7521.0
H2AJ 7388.0
H4C16 7045.0
H2BC13 6942.0
RUVBL1 6916.0
OIP5 6752.0
NPM1 6135.0
H4C8 6011.0
SMARCA5 4664.0
H4C3 4600.0
CENPO 4514.0
H4C4 3780.0
H2BC26 3341.0
H4C1 2954.0
H2AZ2 2797.0
CENPS 2767.0
CENPN 2046.0
CENPK 1809.0
CENPA 1642.0
CENPP 1631.0
CENPU 1542.0
CENPC 1539.0
CENPT 1453.0
H2AC7 427.5
H2BC7 427.5
MIS18A 351.0
RSF1 -580.0
H2AC20 -868.0
H2BC21 -1063.0
H2BC17 -1228.0
CENPH -1308.0
H2BC5 -1467.0
H2BC8 -1568.0
KNL1 -2061.0
H2BC1 -2654.0
CENPL -3214.0
H4C13 -3757.0
CENPQ -3921.0
H4C12 -4032.0
H4C11 -4396.0
H4C2 -4924.0
HJURP -5238.0
H2AC18 -5374.5
H2AC19 -5374.5
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
H2BC3 -7881.0
H2BC11 -8289.0
RBBP4 -8805.0
H2AX -9438.0
CENPM -10116.0
H2BC9 -10890.5


REACTOME_DEUBIQUITINATION

REACTOME_DEUBIQUITINATION
1000
set REACTOME_DEUBIQUITINATION
setSize 260
pANOVA 0.0104
s.dist 0.0923
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
TGFBR1 9787
SMURF2 9689
MBD6 9628
OTUD7A 9449
YOD1 9417
USP7 9312
H2BC14 9173
KAT2A 9007
PSMB6 8978
USP21 8968
H2AC4 8927
H2BC4 8612
H2BC12 8544
KAT2B 8522
TRIM4 8416
POLB 8304
BABAM2 8186
H2AC6 8154

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
TGFBR1 9787.0
SMURF2 9689.0
MBD6 9628.0
OTUD7A 9449.0
YOD1 9417.0
USP7 9312.0
H2BC14 9173.0
KAT2A 9007.0
PSMB6 8978.0
USP21 8968.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
KAT2B 8522.0
TRIM4 8416.0
POLB 8304.0
BABAM2 8186.0
H2AC6 8154.0
USP19 7983.0
PTRH2 7975.0
PSMB2 7872.0
TRAF3 7838.0
CDK1 7783.0
PSMC3 7659.0
RNF123 7621.0
H2AC15 7566.0
USP18 7529.0
H2BC15 7521.0
DDB2 7393.0
MYSM1 7335.0
USP24 7251.0
USP15 7240.0
NOD2 7228.0
NLRP3 7029.0
USP48 7012.0
H2BC13 6942.0
RUVBL1 6916.0
PSMA5 6863.0
PSMA4 6785.0
ZRANB1 6715.0
SMAD3 6582.0
H2AC13 6574.0
WDR20 6551.0
CDC25A 6510.0
USP10 6496.0
H2AC12 6195.0
ACTB 6159.0
ATXN3 5878.0
CLSPN 5858.0
VDAC3 5825.0
USP42 5644.0
SMAD1 5630.0
PSMF1 5602.0
UCHL3 5586.0
AXIN2 5457.0
PSMC1 5450.0
ARRB1 5446.0
SIAH2 5437.0
TAB1 5403.0
H2AC25 5376.0
TNKS2 5118.0
MDM4 5114.0
MDM2 5079.0
TAF10 4993.0
RCE1 4913.0
PSMA8 4836.0
CCNA1 4815.0
USP13 4768.0
STAM 4766.0
PSMA1 4692.0
USP33 4414.0
PSMA7 4345.0
BRCA1 4231.0
OTUD3 4157.0
USP37 4116.0
OTUB2 3994.0
PSME4 3949.0
SMAD2 3835.0
TNIP3 3609.0
CCP110 3574.0
IFIH1 3555.0
HIF1A 3378.0
H2BC26 3341.0
PSMB7 3305.0
USP49 3288.0
RIGI 3274.0
INO80B 3273.0
MCRS1 3196.0
CYLD 3134.0
TADA2B 3059.0
PSMC6 2973.0
NFRKB 2940.0
RNF135 2928.0
AXIN1 2896.0
PSMD7 2868.0
SENP8 2799.0
INO80 2743.0
PSMB1 2738.0
CDC20 2446.0
MYC 2434.0
STAMBPL1 2425.0
KDM1B 2422.0
YY1 2413.0
MAVS 2391.0
USP2 2382.0
USP20 2270.0
FOXK2 2259.0
GATA3 2129.0
SNX3 2100.0
BIRC2 1880.0
RIPK1 1868.0
RHOA 1803.0
JOSD1 1780.0
UIMC1 1750.0
USP5 1603.0
USP30 1522.0
SMAD4 1521.0
PSMD14 1372.0
TNFAIP3 1332.0
MAP3K7 1321.0
RIPK2 1317.0
USP47 1037.0
UBB 959.0
PSMD12 913.0
STAM2 900.0
USP12 864.0
TRAF6 630.0
PSMA6 489.0
H2AC7 427.5
H2BC7 427.5
USP22 374.0
PSMB5 238.0
UFD1 127.0
PSME3 41.0
TP53 -362.0
RHOT1 -501.0
PSMA3 -531.0
SMAD7 -584.0
PSMD6 -607.0
TGFB1 -622.0
NOD1 -634.0
USP28 -638.0
INO80D -709.0
H2AC20 -868.0
SEM1 -983.0
PSMB3 -999.0
VDAC1 -1006.0
H2BC21 -1063.0
IDE -1067.0
INO80C -1187.0
H2BC17 -1228.0
H2AC21 -1268.0
FOXK1 -1349.0
RAD23B -1385.0
H2BC5 -1467.0
TADA3 -1487.0
PTEN -1517.0
RPS27A -1533.0
H2BC8 -1568.0
TNIP1 -1571.0
BABAM1 -1603.0
NFKBIA -1622.0
H2AC16 -1673.0
USP3 -1689.0
INO80E -1929.0
MUL1 -2029.0
OTUD7B -2201.0
SUDS3 -2206.0
USP44 -2236.0
PSMB4 -2273.0
PSMB11 -2276.0
USP34 -2502.0
VCPIP1 -2519.0
H2BC1 -2654.0
MBD5 -2667.0
ACTR8 -2780.0
ASXL2 -2821.0
ATXN7 -2833.0
BAP1 -2897.0
PSMD13 -2965.0
TNKS -3129.0
PSMD5 -3403.0
PSMC5 -3453.0
MAT2B -3508.0
TOMM70 -3528.0
ADRB2 -3715.0
TRRAP -3741.0
APC -3771.0
TGFBR2 -3831.0
UBE2D1 -3868.0
H2AC17 -3931.0
TRIM25 -3997.0
H2AC1 -4057.0
PRKN -4079.0
PSMD4 -4342.0
UCHL1 -4392.0
KEAP1 -4410.0
PSMB9 -4444.0
TNIP2 -4566.0
ASXL1 -4603.0
EP300 -4863.0
ACTL6A -4981.0
TFPT -5128.0
H2AC11 -5298.0
PSME2 -5360.0
H2AC18 -5374.5
H2AC19 -5374.5
USP25 -5425.0
BARD1 -5487.0
USP4 -5518.0
TOMM20 -5667.0
UBA52 -5785.0
JOSD2 -5846.0
PSMB8 -6074.0
WDR48 -6081.0
FKBP8 -6098.0
VCP -6166.0
PSMD1 -6278.0
UBC -6330.0
PSMD11 -6358.0
STAMBP -6378.0
H2AC8 -6437.0
H2BC10 -6470.0
BIRC3 -6662.0
TRAF2 -6761.0
PSMC4 -6772.0
HGS -6788.0
PSMB10 -6982.0
VDAC2 -6995.0
USP14 -7103.0
PSMD2 -7294.0
PSMD8 -7400.0
USP8 -7422.0
PSMA2 -7473.0
CFTR -7584.0
IL33 -7740.0
CCNA2 -7800.0
ESR1 -7821.0
NEDD8 -7872.0
H2BC3 -7881.0
PSMD3 -8072.0
H2BC11 -8289.0
ABRAXAS1 -8340.0
ARRB2 -8388.0
PSME1 -8414.0
PSMD9 -8531.0
SKP2 -8702.0
ABRAXAS2 -8753.0
UCHL5 -8847.0
RAD23A -9010.0
OTUB1 -9244.0
RNF146 -9319.0
ADRM1 -9464.0
USP16 -9581.0
ACTR5 -9762.0
PSMC2 -10548.0
H2BC9 -10890.5
BECN1 -11075.0


REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE

REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE
501
set REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE
setSize 118
pANOVA 0.0105
s.dist 0.136
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
CDKN2B 9129
H2AC4 8927
TNRC6B 8777
IFNB1 8650
H2BC4 8612
H2BC12 8544
H2AC6 8154
AGO3 8091
MIR24-2 8075
TNRC6C 8050
H3C6 7745
H2BC15 7521
CBX8 7514
MAPK1 7485

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
CDKN2B 9129.0
H2AC4 8927.0
TNRC6B 8777.0
IFNB1 8650.0
H2BC4 8612.0
H2BC12 8544.0
H2AC6 8154.0
AGO3 8091.0
MIR24-2 8075.0
TNRC6C 8050.0
H3C6 7745.0
H2BC15 7521.0
CBX8 7514.0
MAPK1 7485.0
FOS 7396.0
H2AJ 7388.0
H4C16 7045.0
H2BC13 6942.0
TXN 6870.0
BMI1 6855.0
MINK1 6711.0
CBX4 6169.0
H3C1 6146.0
H4C8 6011.0
MOV10 5813.0
TNIK 5716.0
MAP2K3 5520.0
MAP4K4 5505.0
MAPK14 5500.0
MDM4 5114.0
MDM2 5079.0
CDKN2D 4610.0
H4C3 4600.0
EED 4516.0
H3C4 4214.0
MAPKAPK3 4120.0
RING1 3881.0
SUZ12 3880.0
H4C4 3780.0
TFDP2 3758.0
TFDP1 3439.0
MAP3K5 3358.0
H2BC26 3341.0
H3-3B 3307.0
JUN 3276.0
H4C1 2954.0
H2AZ2 2797.0
MAPKAPK5 2356.0
TNRC6A 2298.0
MAP2K4 2126.0
H3C2 2089.0
CBX2 2064.0
CDKN2A 1520.0
KDM6B 1294.0
PHC3 1131.0
UBB 959.0
MAP2K7 611.0
H2AC7 427.5
H2BC7 427.5
EZH2 -45.0
SCMH1 -184.0
TP53 -362.0
MIR24-1 -374.0
H3-3A -484.0
H2AC20 -868.0
H2BC21 -1063.0
H2BC17 -1228.0
H2BC5 -1467.0
RPS27A -1533.0
H2BC8 -1568.0
CDK6 -1610.0
MAPK11 -1965.0
H3C10 -2185.0
H2BC1 -2654.0
MAPK3 -3148.0
PHC2 -3516.0
E2F1 -3694.0
H4C13 -3757.0
MAPKAPK2 -3830.0
H4C12 -4032.0
RNF2 -4210.0
MAPK10 -4335.0
PHC1 -4338.0
H3C12 -4347.0
H4C11 -4396.0
MAP2K6 -4491.0
E2F3 -4573.0
H4C2 -4924.0
H3C11 -4941.0
H2AC18 -5374.5
H2AC19 -5374.5
AGO1 -5503.0
CDK4 -5599.0
UBA52 -5785.0
UBC -6330.0
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
CDKN2C -7269.0
MAPK8 -7474.0
CBX6 -7556.0
H2BC3 -7881.0
H2BC11 -8289.0
MAPK9 -8353.0
RBBP4 -8805.0
AGO4 -8898.0
H2AX -9438.0
H3C8 -9824.0
H3C3 -9982.0
E2F2 -10064.0
H2BC9 -10890.5
H3C7 -10890.5


REACTOME_REGULATION_OF_SIGNALING_BY_CBL

REACTOME_REGULATION_OF_SIGNALING_BY_CBL
1435
set REACTOME_REGULATION_OF_SIGNALING_BY_CBL
setSize 22
pANOVA 0.0108
s.dist 0.314
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL 9124
CBL 8324
LYN 7833
BLNK 6992
YES1 6879
FYN 6383
RAPGEF1 5691
PIK3R1 5095
PIK3R2 4716
GRB2 4512
SYK 3145
VAV1 2933
HCK 2444
PIK3CB 2088
UBB 959
PIK3CA 239
CRK -627
PIK3R3 -746
PIK3CD -1420
RPS27A -1533

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL 9124
CBL 8324
LYN 7833
BLNK 6992
YES1 6879
FYN 6383
RAPGEF1 5691
PIK3R1 5095
PIK3R2 4716
GRB2 4512
SYK 3145
VAV1 2933
HCK 2444
PIK3CB 2088
UBB 959
PIK3CA 239
CRK -627
PIK3R3 -746
PIK3CD -1420
RPS27A -1533
UBA52 -5785
UBC -6330


REACTOME_DRUG_ADME

REACTOME_DRUG_ADME
1593
set REACTOME_DRUG_ADME
setSize 103
pANOVA 0.0121
s.dist -0.143
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACSM2A -11621.0
CYP2C8 -11491.0
ADH1A -11486.0
UGT2B17 -11102.0
CES1 -10928.0
GSTA1 -10875.0
SULT1C4 -10765.0
PON1 -10687.0
UGT2B15 -10613.0
UGT2A2 -10597.0
GGT7 -10304.0
SLC22A7 -10171.0
ACSM5 -10003.0
HSD11B1 -9998.0
ACSM2B -9967.5
SULT1E1 -9695.0
SLCO2B1 -9629.0
SLCO1A2 -9311.0
UGT2B4 -9226.0
UGT2A1 -9088.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACSM2A -11621.0
CYP2C8 -11491.0
ADH1A -11486.0
UGT2B17 -11102.0
CES1 -10928.0
GSTA1 -10875.0
SULT1C4 -10765.0
PON1 -10687.0
UGT2B15 -10613.0
UGT2A2 -10597.0
GGT7 -10304.0
SLC22A7 -10171.0
ACSM5 -10003.0
HSD11B1 -9998.0
ACSM2B -9967.5
SULT1E1 -9695.0
SLCO2B1 -9629.0
SLCO1A2 -9311.0
UGT2B4 -9226.0
UGT2A1 -9088.0
HSD11B2 -8935.0
SULT2A1 -8346.0
SLC29A3 -8231.0
CYP2E1 -8092.0
CNDP2 -7746.0
ABCC3 -7443.0
SERPINA6 -7280.0
NME1 -7145.0
GSTA2 -7113.0
SLCO1B1 -6940.0
IMPDH1 -6816.0
CES2 -6748.0
UGT3A1 -6297.0
GLYATL1 -6051.0
SLC29A2 -5557.0
PCK1 -5524.0
PON3 -5318.0
NME2 -5155.0
BCHE -4942.0
BSG -4804.0
NT5C2 -4177.0
SLC22A2 -4011.0
ADAL -3952.0
SLC22A8 -3601.0
ADA -3308.0
ACY1 -3253.0
ABCC4 -2706.0
RAC1 -2405.0
UGT2B11 -2390.0
SLC29A1 -2213.0
SLCO1B3 -2097.0
GMPS -2017.0
ADK -1630.0
GLYATL2 -1611.0
CYP2C9 -1566.0
SLC22A1 -1337.0
ABCB1 -1292.0
ITPA -1246.0
SLC28A3 -1048.0
UGT1A4 -926.0
ABCG2 -882.0
SLC28A2 -847.0
SLC16A1 -714.0
GSTM1 -198.0
UGT3A2 -155.0
GLYAT 320.0
UGT1A3 824.0
GGT5 1001.0
ACSM4 1138.0
ALB 1153.0
VAV2 1201.0
SLC22A3 1475.0
UGT1A7 1551.0
UGT1A5 1639.0
UGT1A9 1831.0
GLYATL3 1921.0
UGT1A6 2271.0
CYP2D6 2536.0
UGT1A10 2701.0
UGT1A8 2804.0
TPMT 2840.0
VAV1 2933.0
PNP 2997.0
UGT1A1 3715.0
GSTP1 3953.0
ABCC5 4069.0
ABCC1 4331.0
VAV3 5004.0
GGT1 5171.0
UGT2A3 5196.0
NAT1 5471.0
XDH 5573.0
ABCC2 5652.0
NAT2 5961.0
NUDT15 6494.0
GUK1 7169.0
UGT2B7 7282.0
CYP2C19 7339.0
GGT6 7854.0
CYP3A4 8392.0
AKR1C1 9069.0
SULT1A1 9357.0
IMPDH2 9726.0


REACTOME_HCMV_LATE_EVENTS

REACTOME_HCMV_LATE_EVENTS
1466
set REACTOME_HCMV_LATE_EVENTS
setSize 110
pANOVA 0.0121
s.dist 0.138
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
VPS37B 9553
H4C5 9308
H4C6 9192
H2BC14 9173
AAAS 9113
NUP93 8999
H2AC4 8927
H2BC4 8612
H2BC12 8544
H2AC6 8154
CHMP3 8014
H3C6 7745
H2AC15 7566
H2BC15 7521
H4C16 7045
H2BC13 6942
VPS37A 6804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
VPS37B 9553.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
AAAS 9113.0
NUP93 8999.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
H2AC6 8154.0
CHMP3 8014.0
H3C6 7745.0
H2AC15 7566.0
H2BC15 7521.0
H4C16 7045.0
H2BC13 6942.0
VPS37A 6804.0
H2AC13 6574.0
NUP58 6427.0
RAE1 6280.0
H2AC12 6195.0
H3C1 6146.0
MVB12B 6109.0
CHMP4A 6039.0
H4C8 6011.0
CHMP7 5822.0
SEH1L 5491.0
NUP210 5481.0
NUP43 5466.0
POM121C 5401.0
H2AC25 5376.0
CHMP2A 5346.0
UBAP1 5341.0
HNRNPK 5091.0
VPS25 4725.0
H4C3 4600.0
NUP62 4592.0
H3C4 4214.0
NUP50 4208.0
NUP155 4169.0
H4C4 3780.0
NUP88 3461.0
H2BC26 3341.0
SNF8 3234.0
H4C1 2954.0
CHMP1A 2585.0
MVB12A 2352.0
H3C2 2089.0
VPS4A 1947.0
NUP35 1878.0
VPS37D 1662.0
NUP214 1146.0
CHMP2B 689.0
NUP160 623.0
CHMP4B 486.0
H2AC7 427.5
H2BC7 427.5
VPS37C 332.0
NUP98 -301.0
TSG101 -577.0
H2AC20 -868.0
NUP153 -967.0
H2BC21 -1063.0
H2BC17 -1228.0
NUP188 -1240.0
H2AC21 -1268.0
NUP85 -1309.0
H2BC5 -1467.0
H2BC8 -1568.0
H2AC16 -1673.0
NUP107 -2066.0
H3C10 -2185.0
H2BC1 -2654.0
NUP54 -3157.0
H4C13 -3757.0
H2AC17 -3931.0
H4C12 -4032.0
H2AC1 -4057.0
NUP42 -4112.0
CHMP4C -4164.0
VPS28 -4200.0
H3C12 -4347.0
H4C11 -4396.0
NUP133 -4485.0
H4C2 -4924.0
H3C11 -4941.0
H2AC11 -5298.0
NUP205 -5309.0
H2AC18 -5374.5
H2AC19 -5374.5
NUP37 -5465.0
H2AC8 -6437.0
H2BC10 -6470.0
TPR -6736.0
CEBPD -6774.0
RANBP2 -7590.0
NDC1 -7862.0
H2BC3 -7881.0
SEC13 -7989.0
H2BC11 -8289.0
VPS36 -8994.0
CHMP6 -9183.0
H3C8 -9824.0
POM121 -9839.0
H3C3 -9982.0
H2BC9 -10890.5
H3C7 -10890.5


REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4

REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4
936
set REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4
setSize 14
pANOVA 0.0127
s.dist -0.384
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF6 -10605
FGFR4 -9736
FGF4 -9155
FGF9 -8071
FGF1 -6320
KLB -6059
FGF23 -5931
FGF8 -5481
PLCG1 -4734
FGF20 -4013
FGF17 -1430
FGF18 -37
FGF2 217
FGF19 2618

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF6 -10605
FGFR4 -9736
FGF4 -9155
FGF9 -8071
FGF1 -6320
KLB -6059
FGF23 -5931
FGF8 -5481
PLCG1 -4734
FGF20 -4013
FGF17 -1430
FGF18 -37
FGF2 217
FGF19 2618


REACTOME_HDACS_DEACETYLATE_HISTONES

REACTOME_HDACS_DEACETYLATE_HISTONES
548
set REACTOME_HDACS_DEACETYLATE_HISTONES
setSize 85
pANOVA 0.0131
s.dist 0.156
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
H2AC4 8927
HMG20B 8656
H2BC4 8612
HDAC1 8575
H2BC12 8544
SAP30L 8265
H2AC6 8154
MTA2 7863
H3C6 7745
H2AC15 7566
H2BC15 7521
CHD3 7121
H4C16 7045
H2BC13 6942

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
HMG20B 8656.0
H2BC4 8612.0
HDAC1 8575.0
H2BC12 8544.0
SAP30L 8265.0
H2AC6 8154.0
MTA2 7863.0
H3C6 7745.0
H2AC15 7566.0
H2BC15 7521.0
CHD3 7121.0
H4C16 7045.0
H2BC13 6942.0
NCOR1 6827.0
H2AC13 6574.0
GATAD2A 6357.0
H2AC12 6195.0
H3C1 6146.0
PHF21A 6132.0
H4C8 6011.0
H2AC25 5376.0
MBD3 5260.0
RCOR1 4633.0
H4C3 4600.0
H3C4 4214.0
MTA3 4098.0
HDAC3 3941.0
H4C4 3780.0
KDM1A 3426.0
H2BC26 3341.0
H4C1 2954.0
HDAC2 2921.0
MTA1 2479.0
H3C2 2089.0
ARID4A 1271.0
H2AC7 427.5
H2BC7 427.5
SAP18 426.0
NCOR2 -439.0
H2AC20 -868.0
CHD4 -1019.0
H2BC21 -1063.0
TBL1XR1 -1114.0
H2BC17 -1228.0
H2AC21 -1268.0
H2BC5 -1467.0
H2BC8 -1568.0
H2AC16 -1673.0
GATAD2B -2140.0
H3C10 -2185.0
SUDS3 -2206.0
H2BC1 -2654.0
REST -2788.0
ARID4B -3522.0
SAP30 -3722.0
H4C13 -3757.0
H2AC17 -3931.0
H4C12 -4032.0
H2AC1 -4057.0
H3C12 -4347.0
H4C11 -4396.0
BRMS1 -4408.0
H4C2 -4924.0
H3C11 -4941.0
H2AC11 -5298.0
H2AC18 -5374.5
H2AC19 -5374.5
H2AC8 -6437.0
H2BC10 -6470.0
HDAC10 -7677.0
H2BC3 -7881.0
H2BC11 -8289.0
GPS2 -8498.0
RBBP4 -8805.0
H3C8 -9824.0
H3C3 -9982.0
H2BC9 -10890.5
H3C7 -10890.5


REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING
29
set REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING
setSize 11
pANOVA 0.014
s.dist -0.428
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
CACNG2 -9917
CACNA1A -8428
CACNB1 -7845
CACNA2D2 -7551
CACNG4 -5859
CACNA1E -4763
CACNA2D3 -4629
CACNB4 -4442
CACNA1B -3912
CACNB3 -1341
CACNB2 -566

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CACNG2 -9917
CACNA1A -8428
CACNB1 -7845
CACNA2D2 -7551
CACNG4 -5859
CACNA1E -4763
CACNA2D3 -4629
CACNB4 -4442
CACNA1B -3912
CACNB3 -1341
CACNB2 -566


REACTOME_FCGR_ACTIVATION

REACTOME_FCGR_ACTIVATION
400
set REACTOME_FCGR_ACTIVATION
setSize 11
pANOVA 0.0143
s.dist 0.426
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGR 9943
FCGR2A 9160
FCGR3A 8638
LYN 7833
YES1 6879
FYN 6383
SYK 3145
HCK 2444
CD3G -153
CD247 -3468
SRC -6713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGR 9943
FCGR2A 9160
FCGR3A 8638
LYN 7833
YES1 6879
FYN 6383
SYK 3145
HCK 2444
CD3G -153
CD247 -3468
SRC -6713


REACTOME_GLUCOCORTICOID_BIOSYNTHESIS

REACTOME_GLUCOCORTICOID_BIOSYNTHESIS
337
set REACTOME_GLUCOCORTICOID_BIOSYNTHESIS
setSize 10
pANOVA 0.0152
s.dist -0.443
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
CYP17A1 -10904
CYP11B2 -10229
HSD11B1 -9998
HSD3B1 -9854
HSD11B2 -8935
SERPINA6 -7280
CYP11B1 -6122
POMC -1564
HSD3B2 1403
CYP21A2 7927

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CYP17A1 -10904
CYP11B2 -10229
HSD11B1 -9998
HSD3B1 -9854
HSD11B2 -8935
SERPINA6 -7280
CYP11B1 -6122
POMC -1564
HSD3B2 1403
CYP21A2 7927


REACTOME_MET_ACTIVATES_RAP1_AND_RAC1

REACTOME_MET_ACTIVATES_RAP1_AND_RAC1
1262
set REACTOME_MET_ACTIVATES_RAP1_AND_RAC1
setSize 11
pANOVA 0.0153
s.dist 0.422
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
CRKL 9124
HGF 8313
RAP1B 6815
RAP1A 6630
RAPGEF1 5691
GRB2 4512
GAB1 4499
MET 1891
CRK -627
DOCK7 -851
RAC1 -2405

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CRKL 9124
HGF 8313
RAP1B 6815
RAP1A 6630
RAPGEF1 5691
GRB2 4512
GAB1 4499
MET 1891
CRK -627
DOCK7 -851
RAC1 -2405


REACTOME_SUMOYLATION

REACTOME_SUMOYLATION
531
set REACTOME_SUMOYLATION
setSize 179
pANOVA 0.0153
s.dist 0.105
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H4C9 9566
ZNF350 9314
H4C5 9308
H4C6 9192
AAAS 9113
NUP93 8999
HDAC1 8575
IKBKE 8098
PCGF2 7831
CBX8 7514
TOP2B 7455
MRTFA 7147
CHD3 7121
HIPK2 7047
H4C16 7045
NR1H3 6906
BMI1 6855
NR1I2 6805
NCOA1 6757
RANGAP1 6692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H4C9 9566
ZNF350 9314
H4C5 9308
H4C6 9192
AAAS 9113
NUP93 8999
HDAC1 8575
IKBKE 8098
PCGF2 7831
CBX8 7514
TOP2B 7455
MRTFA 7147
CHD3 7121
HIPK2 7047
H4C16 7045
NR1H3 6906
BMI1 6855
NR1I2 6805
NCOA1 6757
RANGAP1 6692
SENP5 6511
NUP58 6427
RAE1 6280
CBX4 6169
NPM1 6135
THRB 6127
H4C8 6011
CBX5 6007
SATB2 5997
SMC5 5810
TFAP2C 5725
HNRNPC 5675
SEH1L 5491
NUP210 5481
NUP43 5466
PGR 5440
POM121C 5401
VDR 5209
RARA 5184
HNRNPK 5091
MDM2 5079
SAE1 4847
TFAP2A 4650
H4C3 4600
NUP62 4592
TP53BP1 4581
ZNF131 4527
SMC3 4451
SAFB 4447
PPARGC1A 4347
CDCA8 4262
CTBP1 4233
BRCA1 4231
NUP50 4208
NUP155 4169
TOP1 4134
NR5A2 4066
PPARG 3882
RING1 3881
SUZ12 3880
H4C4 3780
HDAC4 3726
DNMT3B 3676
NUP88 3461
RAD52 3441
PPARA 3420
THRA 3339
NRIP1 3332
WRN 3067
UBA2 2996
H4C1 2954
HDAC2 2921
TOPORS 2904
SP100 2610
STAG1 2515
MTA1 2479
NR3C1 2348
NSMCE3 2281
TFAP2B 2211
PIAS1 2206
CBX2 2064
DNMT3A 2025
NR3C2 2006
NUP35 1878
XRCC4 1686
CDKN2A 1520
NSMCE2 1476
PIAS2 1331
NUP214 1146
SP3 1144
PHC3 1131
RAD21 929
RNF168 921
NSMCE1 752
NUP160 623
SMC6 108
PARP1 99
PARK7 -55
SCMH1 -184
NUP98 -301
TP53 -362
NCOR2 -439
DAXX -514
PML -953
ING2 -960
L3MBTL2 -961
NUP153 -967
FOXL2 -1009
NUP188 -1240
SATB1 -1265
NUP85 -1309
TRIM28 -1565
NFKBIA -1622
VHL -1641
RPA1 -1712
NUP107 -2066
SENP2 -2121
HERC2 -2249
SENP1 -2358
NCOA2 -2483
UHRF2 -2548
RORA -2741
NR1H4 -2811
RELA -2850
TDG -3101
NUP54 -3157
DDX5 -3289
NR2C1 -3335
AURKB -3399
PCNA -3500
PHC2 -3516
NFKB2 -3725
H4C13 -3757
MDC1 -3823
BLM -3849
H4C12 -4032
NUP42 -4112
TOP2A -4160
RNF2 -4210
PHC1 -4338
INCENP -4343
CREBBP -4376
H4C11 -4396
NUP133 -4485
SUMO1 -4803
EP300 -4863
H4C2 -4924
AURKA -5029
NUP205 -5309
MITF -5358
NR1H2 -5389
NUP37 -5465
DDX17 -5523
UBE2I -5588
BIRC5 -5921
SIN3A -6036
TRIM27 -6062
RXRA -6219
DNMT1 -6281
XPC -6305
RWDD3 -6452
NR5A1 -6576
TPR -6736
EID3 -6878
SUMO3 -7184
HIC1 -7499
RANBP2 -7590
SUMO2 -7598
ESR1 -7821
NDC1 -7862
NR4A2 -7931
SEC13 -7989
MBD1 -8066
HDAC7 -8439
NSMCE4A -8942
NOP58 -9254
PIAS4 -9417
POM121 -9839
PIAS3 -10029


REACTOME_TRANSPORT_OF_SMALL_MOLECULES

REACTOME_TRANSPORT_OF_SMALL_MOLECULES
630
set REACTOME_TRANSPORT_OF_SMALL_MOLECULES
setSize 697
pANOVA 0.0157
s.dist -0.0537
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF21 -11478
NIPAL1 -11147
SLC5A4 -11019
CSN1S1 -10987
CLCA1 -10941
SLC4A3 -10931
ATP1A2 -10853
AP2A1 -10826
CLCA4 -10779
SLC26A9 -10667
ABCC6 -10653
SLC9A4 -10622
LCN12 -10596
PLN -10591
PSMC2 -10548
SLC17A1 -10404
SLC9B2 -10401
AQP1 -10382
SLC6A12 -10377
FXYD3 -10215

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF21 -11478
NIPAL1 -11147
SLC5A4 -11019
CSN1S1 -10987
CLCA1 -10941
SLC4A3 -10931
ATP1A2 -10853
AP2A1 -10826
CLCA4 -10779
SLC26A9 -10667
ABCC6 -10653
SLC9A4 -10622
LCN12 -10596
PLN -10591
PSMC2 -10548
SLC17A1 -10404
SLC9B2 -10401
AQP1 -10382
SLC6A12 -10377
FXYD3 -10215
ABCC11 -10198
ATP6V0B -10175
SLC22A7 -10171
RSC1A1 -10071
ATP6V1E1 -10019
SLCO1C1 -9976
FTL -9923
SLC27A4 -9908
CLCNKA -9897
ASIC3 -9891
APOC1 -9841
FTMT -9832
TTYH2 -9811
APOC3 -9743
SLC1A1 -9729
CIDEC -9718
TRPV5 -9689
LPA -9675
SLCO2B1 -9629
SGK2 -9620
LCN9 -9517
AQP7 -9511
HMOX1 -9434
SLC7A9 -9432
TRPV4 -9421
SLC47A2 -9392
ATP6V0E1 -9379
ADCY6 -9314
SLCO1A2 -9311
NGB -9288
GNGT1 -9287
AZGP1 -9246
RHAG -9241
TRPV1 -9218
CASQ1 -9170
SLC34A1 -9163
CLCNKB -9154
RIPK3 -9111
ATP2A1 -9080
BMP1 -9040
TRPM8 -9029
TRPV6 -8996
SLC2A10 -8957
SLN -8882
AQP5 -8876
NALCN -8866
SLC5A5 -8795
ATP6V0E2 -8767
CYB5RL -8745
LMF1 -8693
MRS2 -8684
MFSD4B -8683
SLC7A10 -8671
PSMD9 -8531
SLC39A3 -8511
SLC38A3 -8507
APOA5 -8501
STEAP2 -8475
PSME1 -8414
SLC9B1 -8397
SLC26A3 -8394
SLC1A7 -8373
SLC2A4 -8256
SLC29A3 -8231
SLC38A4 -8228
LMF2 -8190
SLC2A13 -8145
ABCB9 -8134
MLKL -8100
PSMD3 -8072
ANGPTL8 -8013
PRKAR2A -8009
SLC6A5 -7997
SLC2A9 -7973
ATP10B -7946
NEDD8 -7872
SLC39A8 -7871
APOC2 -7859
GLRX3 -7813
SLC1A6 -7792
SLC12A2 -7786
SLC22A15 -7764
TRPM5 -7724
SLC15A3 -7657
FKBP1B -7638
ABCA7 -7613
CES3 -7612
TRPC1 -7597
CFTR -7584
SLC66A1 -7581
PLTP -7575
UNC79 -7535
SLC15A4 -7532
SLC2A7 -7497
PSMA2 -7473
ABCC3 -7443
TRPV3 -7429
NPC1 -7421
PSMD8 -7400
SLC5A6 -7378
ERLIN1 -7359
SCARB1 -7355
SLC24A5 -7298
PSMD2 -7294
ATP1A1 -7244
SLC30A8 -7211
ASIC1 -7094
STEAP3 -7034
VDAC2 -6995
PSMB10 -6982
ADCY5 -6975
ATP6V0A4 -6951
SLCO1B1 -6940
ABCA1 -6923
ABCC9 -6919
ABCA4 -6908
CLCN2 -6846
SLC25A18 -6831
CLCN7 -6805
SLC13A5 -6801
SLC35A3 -6794
ATP6V1E2 -6784
PSMC4 -6772
ATP8A1 -6689
ATP4A -6680
SLC6A9 -6644
ATP8B2 -6634
CUTC -6618
SLC24A1 -6610
SLC26A7 -6599
ABCC10 -6589
PCSK9 -6532
SLC44A1 -6527
ATP13A2 -6474
ATP6V0C -6467
DERL2 -6446
FTH1 -6442
SAR1B -6436
SCNN1B -6429
HFE -6419
SLC4A5 -6416
CSN3 -6402
ATP4B -6380
PSMD11 -6358
UBC -6330
CREB3L3 -6323
PSMD1 -6278
CA2 -6194
VCP -6166
SLC22A4 -6121
PSMB8 -6074
SLC4A7 -6068
AQP3 -6020
CLCA2 -6018
AMN -6011
SLC35D1 -5995
SLC22A6 -5991
ASIC4 -5972
GNG10 -5937
MYO5B -5895
SLC44A3 -5872
CAMK2G -5871
SLC10A6 -5855
ABCD2 -5798
UBA52 -5785
SLC8A2 -5767
ATP6V1D -5749
SLC6A2 -5717
TRPA1 -5696
MB -5690
CYB5R2 -5633
SLC29A2 -5557
GNB1 -5542
SLC26A6 -5499
ABCB4 -5461
ATP2B2 -5455
PCSK5 -5450
NR1H2 -5389
SLC11A1 -5387
ABCB6 -5366
PSME2 -5360
PHB2 -5353
SLC13A3 -5339
ABCA12 -5333
ADCY2 -5332
SLC7A11 -5321
SPG7 -5266
CYB5R1 -5255
SLC8A3 -5178
AQP10 -5123
ADD2 -5117
AQP2 -5106
SLC25A29 -5096
CUBN -5065
SLC2A6 -5058
LRRC8E -5009
SLC6A19 -4932
SLC9A5 -4918
TPCN2 -4903
ATP1A4 -4888
NIPA1 -4877
AP2B1 -4850
SLC35D2 -4845
BSG -4804
FXYD4 -4765
ASIC5 -4736
SLC9A3 -4714
PRKAR1B -4706
SGK3 -4703
SLC5A11 -4644
AQP11 -4628
ABCG8 -4618
STOML2 -4600
ATP1B2 -4588
SLC2A1 -4549
ANO4 -4525
PSMB9 -4444
TRPM1 -4437
ABCA2 -4431
TRDN -4426
SLC26A4 -4394
ADCY4 -4379
ASIC2 -4375
SLC5A3 -4365
APOA2 -4355
PSMD4 -4342
SLCO4C1 -4340
ABCA3 -4226
AFG3L2 -4185
CP -4173
CYB5R4 -4131
SLC36A4 -4129
STOM -4126
SLC7A5 -4081
SLC1A5 -4061
ABCB5 -4059
SLC22A2 -4011
RHCG -4006
CUL1 -3995
ANO8 -3992
ATP7B -3976
EIF2S1 -3962
SLC34A3 -3942
SLC20A1 -3936
SLC38A2 -3871
LCN2 -3866
SLC9A2 -3839
SLC4A4 -3794
IREB2 -3791
BSND -3686
SLC6A18 -3660
KCNJ11 -3653
SLC12A7 -3647
SLC27A1 -3645
ATP8B4 -3631
LIPA -3625
HBB -3618
SLC22A8 -3601
SLCO4A1 -3590
WNK1 -3544
RAB11A -3477
ARL2BP -3476
SLC2A14 -3465
PSMC5 -3453
PSMD5 -3403
ABCG4 -3379
APOA4 -3324
CAMK2A -3320
SLC3A1 -3318
PRKACA -3304
SLC6A20 -3302
ERLIN2 -3256
AQP9 -3254
ABCA5 -3242
SLC12A5 -3215
SLC5A1 -3199
GNB5 -3181
ABCA6 -3152
SLC6A7 -3105
SLC13A4 -3073
GNG7 -3023
SLC38A1 -3015
SLC22A11 -2991
ABCG5 -2975
PSMD13 -2965
ADCY1 -2954
SLC6A1 -2942
SLC4A9 -2860
ATP10A -2813
NIPA2 -2744
GNG12 -2742
RYR1 -2740
ABCC4 -2706
EIF2S2 -2702
SLC39A14 -2701
ABCA8 -2695
SLC17A3 -2689
ATP6V1G1 -2684
CLTA -2675
TCIRG1 -2669
NEDD4L -2637
CALM1 -2630
SLC16A8 -2627
WNK2 -2613
SLC17A8 -2608
SLC35B4 -2514
LPL -2495
SLC39A6 -2456
ABCG1 -2443
LRRC8C -2409
CAMK2B -2408
CTNS -2357
SLC44A2 -2347
AHCYL2 -2308
VLDLR -2303
GNB2 -2299
ATP10D -2293
PSMB11 -2276
PSMB4 -2273
SLC29A1 -2213
SLC25A4 -2212
FXYD1 -2133
SLCO1B3 -2097
SLC39A7 -1899
SLC2A11 -1891
ABCB10 -1871
SLC6A3 -1866
SLC12A3 -1796
NCEH1 -1773
ATP8B3 -1751
SLC24A3 -1743
SLC7A6 -1672
ANO1 -1668
SLC26A2 -1664
NPC2 -1646
LDLRAP1 -1591
ANO7 -1558
ATP6V1B1 -1556
RPS27A -1533
ANO2 -1513
TRPC7 -1511
ATP6V1C1 -1494
PMPCA -1458
SLC9C1 -1436
SLC44A4 -1422
BEST3 -1418
SLC5A2 -1417
ATP1A3 -1363
SLC22A1 -1337
SLC2A12 -1293
ABCB1 -1292
SLC22A18 -1266
LRRC8B -1212
SOAT1 -1170
FBXL5 -1132
PCSK6 -1098
ATP2C2 -1081
ATP8B1 -1052
SLC28A3 -1048
ATP6V0A1 -1032
VDAC1 -1006
PSMB3 -999
RYR3 -990
SEM1 -983
RAF1 -977
FLVCR1 -934
SMDT1 -932
SLC36A1 -904
RYR2 -888
MCOLN2 -885
ABCG2 -882
PEX3 -880
SLC28A2 -847
ADD1 -807
ABCB8 -799
SLC44A5 -772
SLC16A1 -714
HMOX2 -695
SCNN1A -688
CASQ2 -673
SLC25A10 -637
WWP1 -608
PSMD6 -607
HBA2 -590
SGK1 -589
PSMA3 -531
ATP6V1A -530
A2M -395
SLC39A1 -349
ATP9B -310
ATP6V0D2 -264
AQP8 -168
SLC26A11 -86
SLC8B1 -48
AP2S1 -13
TF -11
PSME3 41
SLC12A1 49
SLC30A2 138
PSMB5 238
RNF185 301
SLC2A8 307
SLC35B3 474
NIPAL3 487
PSMA6 489
MICU1 490
ANGPTL3 516
TRPM7 524
TRPC3 540
LDLR 580
FXYD7 693
SLC34A2 729
GNG5 843
SLC50A1 850
PHB1 891
PSMD12 913
SLC11A2 947
ATP13A5 953
UBB 959
ANGPTL4 1056
SLC30A5 1076
ALB 1153
SLC43A2 1158
CAMK2D 1211
GNG3 1215
FXYD6 1247
SLC6A6 1273
SKP1 1275
SLC12A6 1278
ATP9A 1313
ATP13A1 1318
PRKAR2B 1351
GNG4 1353
SLC24A4 1367
PSMD14 1372
SRI 1474
SLC22A3 1475
SLC5A10 1477
ATP11A 1507
SLC24A2 1577
SLC6A15 1586
ANO5 1588
SLC6A11 1634
SLC39A4 1672
GPIHBP1 1719
SLC22A12 1762
SLC20A2 1795
ATP2B4 1802
SLC43A1 1808
ATP8A2 1817
SLC46A1 1864
RIPK1 1868
MCUB 1902
LCN15 2009
SLC13A1 2010
ATP2A2 2091
SLC17A5 2107
HDLBP 2122
SLC6A13 2186
SLC35B2 2198
GNB4 2294
SLC9A8 2315
ADCY8 2346
SLC35A1 2401
ATP6V1H 2508
SLC31A1 2556
ANO9 2631
DMTN 2657
SLC15A2 2665
OSTM1 2694
ADCY9 2707
SLC26A1 2708
PSMB1 2738
TRPM2 2833
UNC80 2865
PSMD7 2868
PSMC6 2973
SLC4A2 2992
TRPM3 3013
SLC25A22 3031
ATP13A4 3034
SLC27A6 3036
ABCF1 3046
SLC32A1 3049
BEST1 3092
ANKH 3133
GNB3 3205
ADCY7 3216
TRPC4AP 3217
SLC39A5 3232
ANO6 3304
PSMB7 3305
SLC33A1 3335
SLC41A1 3338
PRKACB 3366
PMPCB 3406
SLC22A16 3415
MICU2 3423
SLC30A10 3490
RUNX1 3536
ATP6V0A2 3698
LCN1 3759
ABCA10 3787
TUSC3 3832
SCNN1D 3877
ATP6V1G2 3895
TRPC6 3901
PSME4 3949
SLC7A7 3952
LSR 3956
RNF5 3973
MAIP1 3975
SLC47A1 3996
NIPAL4 3997
GNG13 4000
RAB11FIP2 4033
SLC14A1 4035
SLC30A3 4037
SLC45A3 4042
ABCC5 4069
PRKAR1A 4152
ATP11B 4161
TTYH3 4178
ATP6V1C2 4183
SLC14A2 4196
RHBG 4212
SLC1A4 4232
ANO3 4275
DERL1 4318
SLC12A4 4324
ABCC1 4331
PSMA7 4345
TPCN1 4416
ACO1 4437
AP2A2 4438
DERL3 4460
SLC3A2 4540
ATP2C1 4573
SLC28A1 4617
PSMA1 4692
STOML3 4712
SLC41A2 4771
TTYH1 4774
SLC16A3 4822
PSMA8 4836
OS9 4856
PEX19 4875
TFR2 4887
ATP6V1G3 4938
SLC36A2 4961
ATP12A 4965
CLCN3 4989
LIPG 5018
APOB 5074
MTTP 5100
MBTPS1 5148
SLC40A1 5160
WNK4 5173
CA4 5202
SLC17A7 5236
SLC1A2 5262
SLC5A8 5272
APOF 5329
ANO10 5381
ATP6V1F 5385
PSMC1 5450
SLC16A7 5456
SLC9A9 5478
PSMF1 5602
MYLIP 5621
SLC39A10 5622
SLC7A8 5635
ABCC2 5652
TRPM4 5784
SLC7A2 5811
VDAC3 5825
SLCO3A1 5883
ATP6V0D1 5891
PRKACG 5903
LRRC8D 5943
SLC8A1 5950
TRPV2 5962
HBA1 5995
SLC30A1 6008
SLC7A1 6085
SLC4A1 6129
SLC9A1 6200
GNAS 6225
MCOLN3 6231
AKAP1 6310
SCNN1G 6316
ZDHHC8 6340
SLC18A1 6385
SLC1A3 6413
MICU3 6418
CA1 6480
SLC4A8 6532
SLC17A6 6544
MCU 6688
APOC4 6712
LRRC8A 6756
ADCY3 6766
PSMA4 6785
SEL1L 6796
MCOLN1 6807
TRPM6 6821
PSMA5 6863
NR1H3 6906
P4HB 6991
SLC16A10 7005
ABCD3 7036
SLC25A26 7041
SLC13A2 7055
AQP6 7062
ABCA9 7076
SLC5A12 7197
CLTC 7239
AP2M1 7256
CLCN6 7291
SLC35C1 7344
PIP 7368
TRPC4 7410
SLC4A10 7500
ASPH 7524
APOA1 7545
SLCO2A1 7654
PSMC3 7659
YME1L1 7664
CAND1 7719
ATP1B3 7739
ATP1B1 7764
FURIN 7787
ATP2A3 7794
ARL2 7797
SLC22A5 7837
BEST2 7871
PSMB2 7872
SLC29A4 7896
SLC18A2 7917
CYBRD1 7973
TFRC 8027
LIPC 8092
GNG11 8135
SOAT2 8142
GNG8 8220
CLCN1 8319
LETM1 8340
SLC22A17 8393
FXYD2 8496
ADD3 8518
AVP 8538
CYGB 8605
AQP4 8629
ERLEC1 8778
SLC15A1 8825
SLC2A2 8863
LCAT 8909
NIPAL2 8956
SLC5A7 8964
PARL 8965
PSMB6 8978
APOBR 9085
ATP2B1 9150
MIP 9157
CETP 9210
APOE 9271
ATP6V1B2 9309
GNG2 9409
APOD 9441
EMB 9484
SLC2A3 9509
GNGT2 9520
SLC9C2 9530
SLC5A9 9845
SLC39A2 10047
BEST4 10158
AQP12A 10246


REACTOME_MEIOTIC_SYNAPSIS

REACTOME_MEIOTIC_SYNAPSIS
54
set REACTOME_MEIOTIC_SYNAPSIS
setSize 73
pANOVA 0.0161
s.dist 0.163
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
H2AC4 8927
H2BC4 8612
H2BC12 8544
H2AC6 8154
SYCE3 7964
H2BC15 7521
H2AJ 7388
SYCP2 7223
H4C16 7045
SYCP3 6954
H2BC13 6942
POT1 6924
SYCE1 6755
REC8 6586

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
H2AC6 8154.0
SYCE3 7964.0
H2BC15 7521.0
H2AJ 7388.0
SYCP2 7223.0
H4C16 7045.0
SYCP3 6954.0
H2BC13 6942.0
POT1 6924.0
SYCE1 6755.0
REC8 6586.0
TERF2 6539.0
H4C8 6011.0
TERF1 5383.0
SYCE2 5106.0
H4C3 4600.0
SMC3 4451.0
DIDO1 4351.0
BRCA1 4231.0
H4C4 3780.0
SMC1B 3592.0
H2BC26 3341.0
H4C1 2954.0
H2AZ2 2797.0
STAG1 2515.0
LMNB1 1849.0
LMNA 1832.0
RAD21 929.0
SYNE2 705.0
H2AC7 427.5
H2BC7 427.5
SYCP1 -119.0
H3-4 -176.0
SYNE1 -369.0
H2AC20 -868.0
H2BC21 -1063.0
H2BC17 -1228.0
H2BC5 -1467.0
H2BC8 -1568.0
FKBP6 -2315.0
ACD -2576.5
H2BC1 -2654.0
TERF2IP -2690.0
SUN1 -3075.0
H4C13 -3757.0
STAG3 -3961.0
ATR -3983.0
H4C12 -4032.0
H4C11 -4396.0
H4C2 -4924.0
H2AC18 -5374.5
H2AC19 -5374.5
UBE2I -5588.0
TEX12 -6322.0
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
HSPA2 -7305.0
TINF2 -7736.0
H2BC3 -7881.0
H2BC11 -8289.0
SUN2 -8463.0
H2AX -9438.0
H2BC9 -10890.5


REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE

REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE
9
set REACTOME_RECOGNITION_AND_ASSOCIATION_OF_DNA_GLYCOSYLASE_WITH_SITE_CONTAINING_AN_AFFECTED_PURINE
setSize 52
pANOVA 0.0167
s.dist 0.192
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
H2AC4 8927
H2BC4 8612
H2BC12 8544
H2AC6 8154
H2BC15 7521
H2AJ 7388
H4C16 7045
H2BC13 6942
POT1 6924
MPG 6840
TERF2 6539
H4C8 6011
TERF1 5383
H4C3 4600

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
H2AC6 8154.0
H2BC15 7521.0
H2AJ 7388.0
H4C16 7045.0
H2BC13 6942.0
POT1 6924.0
MPG 6840.0
TERF2 6539.0
H4C8 6011.0
TERF1 5383.0
H4C3 4600.0
OGG1 4533.0
MUTYH 4103.0
H4C4 3780.0
H2BC26 3341.0
H4C1 2954.0
H2AZ2 2797.0
NEIL3 1535.0
H2AC7 427.5
H2BC7 427.5
H3-4 -176.0
H2AC20 -868.0
H2BC21 -1063.0
H2BC17 -1228.0
H2BC5 -1467.0
H2BC8 -1568.0
ACD -2576.5
H2BC1 -2654.0
TERF2IP -2690.0
H4C13 -3757.0
H4C12 -4032.0
H4C11 -4396.0
H4C2 -4924.0
H2AC18 -5374.5
H2AC19 -5374.5
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
TINF2 -7736.0
H2BC3 -7881.0
H2BC11 -8289.0
H2AX -9438.0
H2BC9 -10890.5


REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS
720
set REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS
setSize 39
pANOVA 0.0173
s.dist -0.22
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
TAS2R14 -11573
TAS2R31 -11408
TAS2R40 -10973
TAS2R60 -10938
TAS2R7 -10870
TAS2R10 -10714
TAS1R3 -9946
GPRC6A -9541
TAS2R19 -9120
TAS2R16 -8857
TAS2R41 -7661
GRM4 -7631
TAS2R39 -7282
TAS2R5 -7273
GABBR2 -6955
GRM6 -6500
GRM2 -6230
TAS2R8 -6196
TAS2R46 -5231
TAS2R42 -4558

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TAS2R14 -11573
TAS2R31 -11408
TAS2R40 -10973
TAS2R60 -10938
TAS2R7 -10870
TAS2R10 -10714
TAS1R3 -9946
GPRC6A -9541
TAS2R19 -9120
TAS2R16 -8857
TAS2R41 -7661
GRM4 -7631
TAS2R39 -7282
TAS2R5 -7273
GABBR2 -6955
GRM6 -6500
GRM2 -6230
TAS2R8 -6196
TAS2R46 -5231
TAS2R42 -4558
GABBR1 -4234
TAS1R2 -3920
GRM8 -3230
GRM3 -3102
TAS2R38 -2180
TAS2R1 -47
TAS2R20 450
GRM5 605
TAS2R50 1027
CASR 1726
GRM7 2429
GRM1 2495
TAS1R1 2946
TAS2R30 5798
TAS2R9 8932
TAS2R3 9429
TAS2R13 9492
TAS2R4 9782
TAS2R43 10084


REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION

REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION
309
set REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION
setSize 15
pANOVA 0.0174
s.dist -0.355
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF22 -10773
FGF6 -10605
FGF4 -9155
FGF9 -8071
FGF1 -6320
FGF23 -5931
FGF8 -5481
KL -4488
FGF20 -4013
FGFR1 -3965
FGF5 -2655
FGF3 -1593
FGF17 -1430
FGF2 217
FGF10 5528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF22 -10773
FGF6 -10605
FGF4 -9155
FGF9 -8071
FGF1 -6320
FGF23 -5931
FGF8 -5481
KL -4488
FGF20 -4013
FGFR1 -3965
FGF5 -2655
FGF3 -1593
FGF17 -1430
FGF2 217
FGF10 5528


REACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL

REACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL
291
set REACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL
setSize 13
pANOVA 0.0178
s.dist 0.38
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
INPP5J 9501
IMPA1 9281
INPP1 8643
INPP4A 6790
MTMR9 6458
INPP4B 5597
INPP5B 4819
IMPA2 3530
MIOX 2639
SYNJ1 -494
INPP5A -1830
MTMR7 -2432
ISYNA1 -7110

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
INPP5J 9501
IMPA1 9281
INPP1 8643
INPP4A 6790
MTMR9 6458
INPP4B 5597
INPP5B 4819
IMPA2 3530
MIOX 2639
SYNJ1 -494
INPP5A -1830
MTMR7 -2432
ISYNA1 -7110


REACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION

REACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION
312
set REACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION
setSize 11
pANOVA 0.0178
s.dist -0.413
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF6 -10605
FGF4 -9155
FGF9 -8071
FGF1 -6320
FGF23 -5931
FGF8 -5481
FGF20 -4013
FGFR1 -3965
FGF5 -2655
FGF17 -1430
FGF2 217

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF6 -10605
FGF4 -9155
FGF9 -8071
FGF1 -6320
FGF23 -5931
FGF8 -5481
FGF20 -4013
FGFR1 -3965
FGF5 -2655
FGF17 -1430
FGF2 217


REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION
1298
set REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION
setSize 59
pANOVA 0.0178
s.dist 0.178
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
SNAI1 9221
HDAC1 8575
MTA2 7863
CBX8 7514
MAPK1 7485
CHD3 7121
BMI1 6855
SLC38A9 6844
LAMTOR5 6567
GATAD2A 6357
SALL4 6315
CBX4 6169
ATN1 6168
MTOR 5718
MECOM 5518
MBD3 5260
LAMTOR1 4874
RCOR1 4633
EED 4516
MTA3 4098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SNAI1 9221
HDAC1 8575
MTA2 7863
CBX8 7514
MAPK1 7485
CHD3 7121
BMI1 6855
SLC38A9 6844
LAMTOR5 6567
GATAD2A 6357
SALL4 6315
CBX4 6169
ATN1 6168
MTOR 5718
MECOM 5518
MBD3 5260
LAMTOR1 4874
RCOR1 4633
EED 4516
MTA3 4098
HDAC3 3941
PPARG 3882
RING1 3881
SUZ12 3880
EGR1 3741
KDM1A 3426
JUN 3276
HDAC2 2921
LAMTOR3 2812
MTA1 2479
CBX2 2064
RHEB 1567
MAF1 1254
PHC3 1131
RRAGD 1013
EZH2 -45
RRAGA -80
SCMH1 -184
TP53 -362
RPTOR -829
CHD4 -1019
NR2E1 -1263
PTEN -1517
GATAD2B -2140
SNAI2 -2222
HDAC5 -2538
REST -2788
MAPK3 -3148
PHC2 -3516
RNF2 -4210
PHC1 -4338
LAMTOR2 -5925
ATF2 -6318
LAMTOR4 -6874
CBX6 -7556
HDAC7 -8439
RBBP4 -8805
RRAGC -9150
MLST8 -10464


REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS
818
set REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS
setSize 68
pANOVA 0.0181
s.dist 0.166
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H4C9 9566
H4C5 9308
H4C6 9192
AAAS 9113
NUP93 8999
HDAC1 8575
PCGF2 7831
CBX8 7514
CHD3 7121
H4C16 7045
BMI1 6855
NUP58 6427
RAE1 6280
CBX4 6169
H4C8 6011
CBX5 6007
SATB2 5997
SEH1L 5491
NUP210 5481
NUP43 5466

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H4C9 9566
H4C5 9308
H4C6 9192
AAAS 9113
NUP93 8999
HDAC1 8575
PCGF2 7831
CBX8 7514
CHD3 7121
H4C16 7045
BMI1 6855
NUP58 6427
RAE1 6280
CBX4 6169
H4C8 6011
CBX5 6007
SATB2 5997
SEH1L 5491
NUP210 5481
NUP43 5466
POM121C 5401
H4C3 4600
NUP62 4592
NUP50 4208
NUP155 4169
RING1 3881
SUZ12 3880
H4C4 3780
HDAC4 3726
NUP88 3461
H4C1 2954
HDAC2 2921
PIAS1 2206
CBX2 2064
NUP35 1878
PIAS2 1331
NUP214 1146
PHC3 1131
NUP160 623
SCMH1 -184
NUP98 -301
L3MBTL2 -961
NUP153 -967
NUP188 -1240
SATB1 -1265
NUP85 -1309
NUP107 -2066
NUP54 -3157
PHC2 -3516
H4C13 -3757
H4C12 -4032
NUP42 -4112
RNF2 -4210
PHC1 -4338
H4C11 -4396
NUP133 -4485
SUMO1 -4803
H4C2 -4924
NUP205 -5309
NUP37 -5465
UBE2I -5588
TPR -6736
SUMO3 -7184
RANBP2 -7590
SUMO2 -7598
NDC1 -7862
SEC13 -7989
POM121 -9839


REACTOME_FRS_MEDIATED_FGFR1_SIGNALING

REACTOME_FRS_MEDIATED_FGFR1_SIGNALING
940
set REACTOME_FRS_MEDIATED_FGFR1_SIGNALING
setSize 23
pANOVA 0.0183
s.dist -0.284
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF22 -10773
FGF6 -10605
FGF4 -9155
NRAS -8295
FGF9 -8071
HRAS -7878
PTPN11 -7815
FGF1 -6320
FGF23 -5931
FGF8 -5481
KL -4488
FGF20 -4013
FGFR1 -3965
KRAS -3275
FGF5 -2655
FRS2 -2350
FGF3 -1593
FGF17 -1430
FGF2 217
FRS3 1360

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF22 -10773
FGF6 -10605
FGF4 -9155
NRAS -8295
FGF9 -8071
HRAS -7878
PTPN11 -7815
FGF1 -6320
FGF23 -5931
FGF8 -5481
KL -4488
FGF20 -4013
FGFR1 -3965
KRAS -3275
FGF5 -2655
FRS2 -2350
FGF3 -1593
FGF17 -1430
FGF2 217
FRS3 1360
GRB2 4512
SOS1 4943
FGF10 5528


REACTOME_FRS_MEDIATED_FGFR4_SIGNALING

REACTOME_FRS_MEDIATED_FGFR4_SIGNALING
948
set REACTOME_FRS_MEDIATED_FGFR4_SIGNALING
setSize 21
pANOVA 0.0186
s.dist -0.297
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF6 -10605
FGFR4 -9736
FGF4 -9155
NRAS -8295
FGF9 -8071
HRAS -7878
PTPN11 -7815
FGF1 -6320
KLB -6059
FGF23 -5931
FGF8 -5481
FGF20 -4013
KRAS -3275
FRS2 -2350
FGF17 -1430
FGF18 -37
FGF2 217
FRS3 1360
FGF19 2618
GRB2 4512

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF6 -10605
FGFR4 -9736
FGF4 -9155
NRAS -8295
FGF9 -8071
HRAS -7878
PTPN11 -7815
FGF1 -6320
KLB -6059
FGF23 -5931
FGF8 -5481
FGF20 -4013
KRAS -3275
FRS2 -2350
FGF17 -1430
FGF18 -37
FGF2 217
FRS3 1360
FGF19 2618
GRB2 4512
SOS1 4943


REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN
1191
set REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN
setSize 15
pANOVA 0.019
s.dist 0.35
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
GP9 10261
GP1BA 9962
ITGB1 8797
ITGA2 8659
LYN 7833
ITGA10 7563
FCER1G 6792
FYN 6383
ITGA1 835
GP5 726
COL1A2 -289
GP1BB -2807
COL1A1 -3656
GP6 -5561
VWF -8042

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GP9 10261
GP1BA 9962
ITGB1 8797
ITGA2 8659
LYN 7833
ITGA10 7563
FCER1G 6792
FYN 6383
ITGA1 835
GP5 726
COL1A2 -289
GP1BB -2807
COL1A1 -3656
GP6 -5561
VWF -8042


REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION

REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
611
set REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION
setSize 22
pANOVA 0.0193
s.dist -0.288
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
EPRS1 -10225
MARS1 -9902
YARS1 -8545
PPA1 -8027
CARS1 -7622
NARS1 -6291
LARS1 -6167
EEF1E1 -6126
TARS1 -5905
AARS1 -5457
WARS1 -5373
KARS1 -5031
HARS1 -4887
FARSA -3574
IARS1 -3297
AIMP1 -1394
GARS1 -1369
RARS1 -962
FARSB 934
DARS1 3226

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EPRS1 -10225
MARS1 -9902
YARS1 -8545
PPA1 -8027
CARS1 -7622
NARS1 -6291
LARS1 -6167
EEF1E1 -6126
TARS1 -5905
AARS1 -5457
WARS1 -5373
KARS1 -5031
HARS1 -4887
FARSA -3574
IARS1 -3297
AIMP1 -1394
GARS1 -1369
RARS1 -962
FARSB 934
DARS1 3226
VARS1 3789
AIMP2 7532


REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION

REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION
1169
set REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION
setSize 59
pANOVA 0.0201
s.dist 0.175
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
H2AC4 8927
H2BC4 8612
H2BC12 8544
H2AC6 8154
H2BC15 7521
H2AJ 7388
H4C16 7045
H2BC13 6942
POT1 6924
MPG 6840
TERF2 6539
H4C8 6011
TERF1 5383
NTHL1 5038

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
H2BC4 8612.0
H2BC12 8544.0
H2AC6 8154.0
H2BC15 7521.0
H2AJ 7388.0
H4C16 7045.0
H2BC13 6942.0
POT1 6924.0
MPG 6840.0
TERF2 6539.0
H4C8 6011.0
TERF1 5383.0
NTHL1 5038.0
H4C3 4600.0
OGG1 4533.0
MUTYH 4103.0
H4C4 3780.0
H2BC26 3341.0
NEIL1 3198.0
H4C1 2954.0
H2AZ2 2797.0
NEIL2 1658.0
NEIL3 1535.0
H2AC7 427.5
H2BC7 427.5
UNG 222.0
MBD4 52.0
H3-4 -176.0
H2AC20 -868.0
H2BC21 -1063.0
H2BC17 -1228.0
H2BC5 -1467.0
H2BC8 -1568.0
ACD -2576.5
H2BC1 -2654.0
TERF2IP -2690.0
TDG -3101.0
H4C13 -3757.0
H4C12 -4032.0
H4C11 -4396.0
H4C2 -4924.0
H2AC18 -5374.5
H2AC19 -5374.5
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
TINF2 -7736.0
H2BC3 -7881.0
SMUG1 -8121.0
H2BC11 -8289.0
H2AX -9438.0
H2BC9 -10890.5


REACTOME_VISUAL_PHOTOTRANSDUCTION

REACTOME_VISUAL_PHOTOTRANSDUCTION
473
set REACTOME_VISUAL_PHOTOTRANSDUCTION
setSize 93
pANOVA 0.0204
s.dist -0.139
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
CLPS -11492
RHO -11267
OPN1SW -11200
GUCA1C -11120
RBP3 -10984
PNLIP -10981
RCVRN -10873
GUCA1A -10808
STRA6 -10512
SDC3 -10286
HSD17B1 -10152
APOC3 -9743
RDH16 -9671
RGS9BP -9508
GNGT1 -9287
RDH12 -8652
AGRN -8628
HSD17B6 -8208
APOC2 -7859
HSPG2 -7846

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CLPS -11492
RHO -11267
OPN1SW -11200
GUCA1C -11120
RBP3 -10984
PNLIP -10981
RCVRN -10873
GUCA1A -10808
STRA6 -10512
SDC3 -10286
HSD17B1 -10152
APOC3 -9743
RDH16 -9671
RGS9BP -9508
GNGT1 -9287
RDH12 -8652
AGRN -8628
HSD17B6 -8208
APOC2 -7859
HSPG2 -7846
PDE6B -7649
RLBP1 -7601
CYP4V2 -7265
RETSAT -7168
ABCA4 -6908
GUCA1B -6684
SLC24A1 -6610
CAMKMT -5877
AKR1C4 -5750
GNAT1 -5677
RDH8 -5593
GNB1 -5542
RGS9 -5471
FNTA -5313
LRP2 -4997
CNGA1 -4919
MYO7A -4640
PDE6G -4530
APOA2 -4355
LRP1 -4172
RDH10 -4084
GPC1 -3808
BCO2 -3773
NMT2 -3529
APOA4 -3324
GNB5 -3181
SDC1 -2906
GPC2 -2818
CALM1 -2630
LPL -2495
BCO1 -2229
GRK1 -2035
LRP12 -2005
AKR1B10 -892
GRK7 -396
NMT1 -146
APOM 175
GPC6 479
LDLR 580
LRP8 698
RBP1 713
FNTB 854
GRK4 962
RBP2 1179
PRKCQ 1412
SDC2 1596
GPIHBP1 1719
DHRS9 2703
CNGB1 2718
AKR1C3 2861
GPC5 2943
NAPEPLD 3187
SDC4 3350
RDH11 3408
DHRS3 3421
SAG 3802
PRKCA 4097
LRAT 4471
METAP1 4756
RBP4 4953
APOB 5074
RPE65 5253
LRP10 5794
TTR 5864
RDH5 6042
PDE6A 6083
APOA1 7545
PLB1 8131
SDR9C7 8179
GUCY2D 8326
AKR1C1 9069
METAP2 9154
APOE 9271


REACTOME_CELL_CYCLE

REACTOME_CELL_CYCLE
190
set REACTOME_CELL_CYCLE
setSize 666
pANOVA 0.0207
s.dist 0.0526
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
E2F6 10036
TEX15 10027
H2BC6 9804
CENPW 9794
DYNLL2 9781
H4C9 9566
MAD2L1 9372
H4C5 9308
SFN 9296
ITGB3BP 9201
CDK11A 9200
H4C6 9192
H2BC14 9173
CDKN2B 9129
RMI1 9120
AAAS 9113
RNF8 9094
NUP93 8999
PSMB6 8978

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
E2F6 10036.0
TEX15 10027.0
H2BC6 9804.0
CENPW 9794.0
DYNLL2 9781.0
H4C9 9566.0
MAD2L1 9372.0
H4C5 9308.0
SFN 9296.0
ITGB3BP 9201.0
CDK11A 9200.0
H4C6 9192.0
H2BC14 9173.0
CDKN2B 9129.0
RMI1 9120.0
AAAS 9113.0
RNF8 9094.0
NUP93 8999.0
PSMB6 8978.0
H2AC4 8927.0
BLZF1 8915.0
RTEL1 8859.0
ZWILCH 8829.0
DMC1 8711.0
ANAPC4 8697.0
H2BC4 8612.0
HDAC1 8575.0
RAD51C 8563.0
H2BC12 8544.0
MIS18BP1 8533.0
KIF2B 8460.0
POLR2C 8456.0
MZT1 8382.0
ANAPC15 8282.0
WAPL 8250.0
BABAM2 8186.0
RAD9A 8160.0
H2AC6 8154.0
TUBGCP3 8146.0
BORA 8130.0
LBR 8124.0
BUB1 8088.0
ANAPC10 8035.0
CHMP3 8014.0
CSNK2A2 7992.0
SYCE3 7964.0
PSMB2 7872.0
LYN 7833.0
PDS5B 7813.0
CDK1 7783.0
H3C6 7745.0
DNA2 7731.0
NME7 7713.0
PSMC3 7659.0
HAUS2 7624.0
FBXO5 7577.0
STN1 7561.0
H2BC15 7521.0
MAPK1 7485.0
CDC6 7453.0
H2AJ 7388.0
NEK6 7366.0
PRKCB 7313.0
PPP2R2D 7260.0
SYCP2 7223.0
SKA2 7219.0
CCNB2 7189.0
CEP41 7167.0
SHQ1 7102.0
H4C16 7045.0
ZW10 7031.0
MCM8 7023.0
FBXL18 6990.0
SYCP3 6954.0
H2BC13 6942.0
POT1 6924.0
RUVBL1 6916.0
ZWINT 6868.0
PSMA5 6863.0
PPP1CC 6850.0
RPA3 6839.0
PSMA4 6785.0
TUBA3D 6758.0
SYCE1 6755.0
OIP5 6752.0
RAD50 6740.0
LPIN2 6709.0
RANGAP1 6692.0
CDK5RAP2 6625.0
REC8 6586.0
TERF2 6539.0
FEN1 6533.0
CDC25A 6510.0
POLR2A 6509.0
POLR2B 6462.0
PTTG1 6441.0
BRIP1 6430.0
NUP58 6427.0
POLE3 6416.0
CLASP1 6369.0
RAE1 6280.0
DYNC1I1 6233.0
ANKRD28 6224.0
LIG1 6203.0
H3C1 6146.0
NPM1 6135.0
KPNB1 6064.0
CHMP4A 6039.0
H4C8 6011.0
AKT1 5992.0
SIRT2 5915.0
CLSPN 5858.0
NUMA1 5843.0
CHMP7 5822.0
PRIM2 5682.0
AKAP9 5680.0
CDC25C 5604.0
PSMF1 5602.0
TUBB4A 5584.0
ESPL1 5575.0
KMT5A 5574.0
CEP57 5570.0
ANAPC7 5551.0
SEH1L 5491.0
DHFR 5482.0
NUP210 5481.0
NUP43 5466.0
PSMC1 5450.0
TNPO1 5424.0
POM121C 5401.0
MCM6 5384.0
TERF1 5383.0
CENPF 5378.0
RFC1 5369.0
CHMP2A 5346.0
CLIP1 5331.0
RBL2 5227.0
ATRIP 5203.0
TUBAL3 5121.0
MDM4 5114.0
CDC16 5113.0
SYCE2 5106.0
POLR2K 5096.0
MDM2 5079.0
CKS1B 4996.0
NSD2 4994.0
GOLGA2 4973.0
AKT3 4944.0
POLE4 4855.0
PSMA8 4836.0
NUF2 4821.0
CCNA1 4815.0
COP1 4770.0
NEK7 4742.0
SPDL1 4714.0
MCPH1 4710.0
PSMA1 4692.0
MCM3 4683.0
SMARCA5 4664.0
CDKN2D 4610.0
SDCCAG8 4607.0
H4C3 4600.0
CDK7 4596.0
NUP62 4592.0
TP53BP1 4581.0
RAD9B 4530.0
CENPO 4514.0
LIN52 4504.0
DCTN2 4497.0
PPP2R2A 4477.0
SMC3 4451.0
CABLES1 4433.0
DIDO1 4351.0
PSMA7 4345.0
LIN54 4313.0
CDCA8 4262.0
BRCA1 4231.0
H3C4 4214.0
NUP50 4208.0
PCM1 4197.0
NUP155 4169.0
SGO1 4155.0
DYRK1A 4128.0
MCM4 4099.0
PRKCA 4097.0
CEP63 4090.0
CEP78 4089.0
CDKN1C 4054.0
CTDNEP1 4052.0
CCND3 4041.0
DYNC1LI2 4016.0
PSME4 3949.0
TUBG2 3948.0
PRIM1 3915.0
PLK1 3883.0
CNTRL 3854.0
GINS4 3830.0
HSP90AB1 3800.0
H4C4 3780.0
MYBL2 3771.0
POLA2 3770.0
TFDP2 3758.0
NCAPD2 3734.0
VRK1 3720.0
ABL1 3708.0
TOPBP1 3665.0
LPIN1 3631.0
SMC1B 3592.0
RAB2A 3582.0
CCP110 3574.0
YWHAQ 3525.0
DYNC1H1 3523.0
TUBB2A 3522.0
MAD1L1 3521.0
TUBB4B 3511.0
DYNC1I2 3507.0
NUP88 3461.0
NEDD1 3459.0
TFDP1 3439.0
MSH4 3422.0
H2BC26 3341.0
H3-3B 3307.0
PSMB7 3305.0
MCM10 3239.0
MASTL 3163.0
SGO2 3093.0
GMNN 3085.0
WRN 3067.0
GINS3 3015.0
AHCTF1 3005.0
PLK4 2993.0
POLD4 2987.0
PSMC6 2973.0
H4C1 2954.0
CDC7 2880.0
PSMD7 2868.0
YWHAG 2834.0
H2AZ2 2797.0
CENPS 2767.0
CEP250 2760.0
CDC25B 2755.0
PSMB1 2738.0
ORC3 2732.0
TUBB1 2727.0
MSH5 2716.0
TUBGCP4 2681.0
CDT1 2613.0
RBBP8 2583.0
PTK6 2560.0
CSNK1E 2537.0
DCTN1 2525.0
POLD2 2520.0
STAG1 2515.0
MCM5 2504.0
PCBP4 2497.0
FOXM1 2490.0
MND1 2481.0
CDC20 2446.0
MYC 2434.0
HAUS1 2213.0
CEP290 2173.0
H3C2 2089.0
PPP2CA 2075.0
CDKN1A 2061.0
CENPN 2046.0
VPS4A 1947.0
CEP70 1893.0
NUP35 1878.0
PPP1R12B 1852.0
LMNB1 1849.0
LMNA 1832.0
CENPK 1809.0
UIMC1 1750.0
PPP6R3 1702.0
MLH1 1661.0
CENPA 1642.0
CENPP 1631.0
CENPU 1542.0
CENPC 1539.0
CDKN2A 1520.0
TK1 1495.0
CENPT 1453.0
PPP2R5C 1426.0
YWHAZ 1414.0
PSMD14 1372.0
PRKAR2B 1351.0
CDC27 1330.0
SKP1 1275.0
ANAPC16 1261.0
RFC2 1255.0
TUBGCP2 1253.0
NCAPH2 1199.0
NUP214 1146.0
ORC4 1129.0
ANAPC5 1086.0
LCMT1 1045.0
UBB 959.0
NDEL1 932.0
RAD21 929.0
RNF168 921.0
PSMD12 913.0
SPC25 898.0
EXO1 877.0
NOP10 757.0
NCAPD3 738.0
CSNK1D 725.0
SYNE2 705.0
CHMP2B 689.0
CENPE 671.0
RAN 668.0
NUP160 623.0
KIF2C 573.0
PSMA6 489.0
CHMP4B 486.0
XPO1 477.0
RAD1 432.0
H2AC7 427.5
H2BC7 427.5
SKA1 415.0
PMF1 358.0
MIS18A 351.0
POLE 310.0
GINS1 308.0
TAOK1 281.0
PSMB5 238.0
CDC26 171.0
SPAST 140.0
CLASP2 124.0
NBN 122.0
LIN9 50.0
PSME3 41.0
NSL1 -1.0
POLE2 -50.0
KIF20A -93.0
SYCP1 -119.0
ORC6 -144.0
DYNC1LI1 -156.0
H3-4 -176.0
TUBA1A -177.0
MIS12 -233.0
NUP98 -301.0
TEN1 -302.0
BRCA2 -320.0
DBF4 -359.0
TP53 -362.0
SYNE1 -369.0
TOP3A -404.0
PPP2R5B -431.0
CEP192 -461.0
H3-3A -484.0
E2F5 -512.0
DAXX -514.0
PPME1 -526.0
PSMA3 -531.0
RSF1 -580.0
PSMD6 -607.0
VRK2 -645.0
MAX -694.0
PPP1R12A -735.0
RAB8A -761.0
H2AC20 -868.0
PHF20 -889.0
NUP153 -967.0
SEM1 -983.0
SMC4 -997.0
PSMB3 -999.0
EML4 -1024.0
H2BC21 -1063.0
RFC4 -1101.0
BUB1B -1107.0
TUBB -1135.0
RCC2 -1163.0
CDK2 -1193.0
KIF18A -1202.0
H2BC17 -1228.0
JAK2 -1231.0
NUP188 -1240.0
HSP90AA1 -1251.0
ALMS1 -1298.0
BANF1 -1306.0
CENPH -1308.0
NUP85 -1309.0
RAD51 -1314.0
RB1 -1329.0
FZR1 -1416.0
HAUS5 -1433.0
H2BC5 -1467.0
RPS27A -1533.0
H2BC8 -1568.0
BABAM1 -1603.0
CDK6 -1610.0
CENPJ -1657.0
MNAT1 -1663.0
TYMS -1682.0
TUBA8 -1700.0
RPA1 -1712.0
CEP152 -1778.0
MRE11 -1827.0
PPP2R5E -1853.0
NCAPG -1970.0
KNL1 -2061.0
NUP107 -2066.0
NEK9 -2118.0
CCNE1 -2144.0
POLR2H -2163.0
H3C10 -2185.0
ORC2 -2191.0
ANAPC1 -2202.0
PSMC3IP -2211.0
HMMR -2230.0
GSK3B -2244.0
HERC2 -2249.0
PSMB4 -2273.0
PSMB11 -2276.0
FKBP6 -2315.0
NIPBL -2362.0
TUBB2B -2381.0
ENSA -2419.0
BUB3 -2438.0
ZNF385A -2507.0
FBXL7 -2517.0
ESCO2 -2551.0
ACD -2576.5
SPO11 -2582.0
PCNT -2632.0
H2BC1 -2654.0
TERF2IP -2690.0
CHEK1 -2710.0
CEP76 -2719.0
KIF23 -2736.0
RBL1 -2771.0
CNEP1R1 -2772.0
FKBPL -2806.0
PDS5A -2857.0
PSMD13 -2965.0
UBE2E1 -2989.0
SET -3059.0
CDC23 -3072.0
SUN1 -3075.0
ORC5 -3083.0
CDK11B -3084.0
MAPK3 -3148.0
NUP54 -3157.0
RRM2 -3193.0
CENPL -3214.0
CTC1 -3219.0
PRKACA -3304.0
RCC1 -3348.0
ODF2 -3370.0
AURKB -3399.0
PSMD5 -3403.0
UBE2V2 -3410.0
PSMC5 -3453.0
PCNA -3500.0
E2F4 -3537.0
TUBA4A -3571.0
E2F1 -3694.0
ESCO1 -3702.0
MAPRE1 -3732.0
H4C13 -3757.0
MDC1 -3823.0
BLM -3849.0
MLH3 -3857.0
LEMD2 -3865.0
UBE2D1 -3868.0
CENPQ -3921.0
STAG3 -3961.0
ATR -3983.0
CUL1 -3995.0
H4C12 -4032.0
KIF2A -4051.0
POLR2F -4072.0
NUP42 -4112.0
RHNO1 -4124.0
PPP1CB -4125.0
TOP2A -4160.0
CHMP4C -4164.0
CDKN1B -4265.0
CEP164 -4276.0
POLD1 -4297.0
YWHAE -4316.0
PSMD4 -4342.0
INCENP -4343.0
GINS2 -4346.0
H3C12 -4347.0
H4C11 -4396.0
PSMB9 -4444.0
B9D2 -4469.0
NUDC -4470.0
NUP133 -4485.0
GORASP1 -4494.0
RFC5 -4495.0
ATM -4524.0
WEE1 -4526.0
E2F3 -4573.0
CHEK2 -4590.0
KAT5 -4635.0
PAFAH1B1 -4661.0
CCNB1 -4737.0
BTRC -4751.0
AKT2 -4789.0
LEMD3 -4795.0
SUMO1 -4803.0
EP300 -4863.0
H4C2 -4924.0
CEP43 -4933.0
GTSE1 -4939.0
H3C11 -4941.0
AURKA -5029.0
CCND1 -5032.0
FBXW11 -5045.0
PRDM9 -5119.0
WRAP53 -5163.0
NCAPH -5223.0
CEP72 -5226.0
SFI1 -5235.0
HJURP -5238.0
NUP205 -5309.0
PPP2R5A -5328.0
PSME2 -5360.0
H2AC18 -5374.5
H2AC19 -5374.5
PPP2CB -5388.0
NUP37 -5465.0
BARD1 -5487.0
DSN1 -5535.0
UBE2I -5588.0
USO1 -5597.0
CDK4 -5599.0
CSNK2B -5656.0
CHTF8 -5678.0
DYNLL1 -5706.0
PPP2R1A -5723.0
MCM7 -5728.0
POLR2I -5741.0
CCNH -5745.0
HUS1 -5768.0
UBA52 -5785.0
CHTF18 -5863.0
PPP2R1B -5897.0
BIRC5 -5921.0
TPX2 -5932.0
IST1 -5950.0
ANKLE2 -5962.0
ORC1 -6054.0
PSMB8 -6074.0
DSCC1 -6077.0
ACTR1A -6110.0
NHP2 -6117.0
POLD3 -6198.0
NCAPG2 -6206.0
TERT -6237.0
LPIN3 -6276.0
PSMD1 -6278.0
TUBGCP6 -6292.0
TEX12 -6322.0
UBC -6330.0
PSMD11 -6358.0
RUVBL2 -6379.0
KNTC1 -6406.0
H2AC8 -6437.0
H2BC10 -6470.0
HAUS6 -6488.0
HAUS8 -6558.0
CDC45 -6624.0
TUBB6 -6632.0
NDE1 -6638.0
ANAPC11 -6653.0
MCM2 -6712.0
SRC -6713.0
TPR -6736.0
CSNK2A1 -6744.0
PSMC4 -6772.0
CCND2 -6861.0
UBE2S -6896.0
PSMB10 -6982.0
RAB1B -6991.0
CCNE2 -7017.0
H2AZ1 -7039.0
POLR2J -7121.0
POLR2L -7128.0
TUBA4B -7208.0
NDC80 -7233.0
CDKN2C -7269.0
AJUBA -7286.0
PSMD2 -7294.0
HSPA2 -7305.0
HAUS3 -7347.0
GAR1 -7363.0
PSMD8 -7400.0
PSMA2 -7473.0
PKMYT1 -7477.0
RBX1 -7501.0
CEP131 -7506.0
TUBA1B -7561.0
RANBP2 -7590.0
CC2D1B -7726.0
TINF2 -7736.0
TUBGCP5 -7742.0
RPA2 -7797.0
CCNA2 -7800.0
NDC1 -7862.0
H2BC3 -7881.0
ANAPC2 -7903.0
POLR2G -7972.0
SEC13 -7989.0
PPP2R5D -8049.0
PSMD3 -8072.0
YWHAH -8187.0
H2BC11 -8289.0
ABRAXAS1 -8340.0
RMI2 -8360.0
YWHAB -8378.0
PSME1 -8414.0
SUN2 -8463.0
TUBG1 -8500.0
PSMD9 -8531.0
CKAP5 -8559.0
RFC3 -8673.0
SKP2 -8702.0
GORASP2 -8790.0
UBE2C -8798.0
CDCA5 -8801.0
RBBP4 -8805.0
PHLDA1 -8820.0
MAU2 -8838.0
RPS27 -8972.0
TUBA3C -8978.0
NEK2 -8980.0
SMC2 -9007.0
CDC14A -9050.0
SSNA1 -9061.0
PIF1 -9064.0
POLR2E -9075.0
ARPP19 -9134.0
CHMP6 -9183.0
PPP6C -9186.0
SPC24 -9282.0
TUBB3 -9409.0
PIAS4 -9417.0
H2AX -9438.0
RAD17 -9459.0
TMPO -9513.0
HAUS4 -9683.0
LIN37 -9808.0
H3C8 -9824.0
POM121 -9839.0
RAB1A -9914.0
CEP135 -9935.0
UBE2N -9943.0
OPTN -9963.0
H3C3 -9982.0
TUBA1C -9991.0
E2F2 -10064.0
CENPM -10116.0
DCTN3 -10196.0
MZT2B -10387.0
POLR2D -10447.0
PSMC2 -10548.0
NINL -10732.0
MZT2A -10786.0
TUBA3E -10852.0
H2BC9 -10890.5
H3C7 -10890.5
TUBB8 -11501.0


REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION

REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION
308
set REACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION
setSize 19
pANOVA 0.021
s.dist -0.306
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGF22 -10773
FGF6 -10605
FGFBP1 -9664
FGFBP3 -9232
FGF4 -9155
FGF9 -8071
FGF1 -6320
FGF23 -5931
FGF8 -5481
FGF20 -4013
FGF5 -2655
FGF3 -1593
FGFBP2 -1540
FGF17 -1430
FGFR2 -1302
FGF18 -37
FGF2 217
FGF7 5212
FGF10 5528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGF22 -10773
FGF6 -10605
FGFBP1 -9664
FGFBP3 -9232
FGF4 -9155
FGF9 -8071
FGF1 -6320
FGF23 -5931
FGF8 -5481
FGF20 -4013
FGF5 -2655
FGF3 -1593
FGFBP2 -1540
FGF17 -1430
FGFR2 -1302
FGF18 -37
FGF2 217
FGF7 5212
FGF10 5528


REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING
320
set REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING
setSize 112
pANOVA 0.0212
s.dist 0.126
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
KAT2A 9007
H2AC4 8927
TNRC6B 8777
NOTCH2 8693
H2BC4 8612
MIR200C 8580
H2BC12 8544
KAT2B 8522
H2AC6 8154
AGO3 8091
TNRC6C 8050
MIR200B 7845
ATP2A3 7794
FURIN 7787

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
KAT2A 9007.0
H2AC4 8927.0
TNRC6B 8777.0
NOTCH2 8693.0
H2BC4 8612.0
MIR200C 8580.0
H2BC12 8544.0
KAT2B 8522.0
H2AC6 8154.0
AGO3 8091.0
TNRC6C 8050.0
MIR200B 7845.0
ATP2A3 7794.0
FURIN 7787.0
H3C6 7745.0
H2BC15 7521.0
H2AJ 7388.0
H4C16 7045.0
H2BC13 6942.0
SEL1L 6796.0
MIR34B 6469.0
H3C1 6146.0
MAML3 6112.0
H4C8 6011.0
MOV10 5813.0
ST3GAL4 5434.0
MIR34C 5092.0
B4GALT1 4941.0
H4C3 4600.0
AGO2 4556.0
H3C4 4214.0
PRKCI 3984.0
H4C4 3780.0
TFDP2 3758.0
RUNX1 3536.0
TFDP1 3439.0
MIR449A 3402.0
H2BC26 3341.0
H3-3B 3307.0
JUN 3276.0
H4C1 2954.0
MFNG 2872.0
H2AZ2 2797.0
MAML1 2741.0
MAML2 2661.0
MIR302A 2367.5
TNRC6A 2298.0
ATP2A2 2091.0
H3C2 2089.0
MIR449B 2073.0
NOTCH1 2011.0
RAB6A 984.0
H2AC7 427.5
H2BC7 427.5
ST3GAL3 67.0
TP53 -362.0
H3-3A -484.0
MIR150 -690.0
H2AC20 -868.0
LFNG -942.0
ELF3 -978.0
TMED2 -1004.0
H2BC21 -1063.0
H2BC17 -1228.0
H2BC5 -1467.0
H2BC8 -1568.0
RFNG -1649.0
H3C10 -2185.0
ST3GAL6 -2635.0
H2BC1 -2654.0
MIR449C -2862.0
RBPJ -2983.0
E2F1 -3694.0
H4C13 -3757.0
H4C12 -4032.0
POFUT1 -4042.0
H3C12 -4347.0
CREBBP -4376.0
H4C11 -4396.0
SNW1 -4439.0
E2F3 -4573.0
EP300 -4863.0
H4C2 -4924.0
H3C11 -4941.0
CCND1 -5032.0
H2AC18 -5374.5
H2AC19 -5374.5
AGO1 -5503.0
POGLUT1 -5700.0
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
H2BC3 -7881.0
NOTCH4 -8210.0
H2BC11 -8289.0
AGO4 -8898.0
ATP2A1 -9080.0
H2AX -9438.0
H3C8 -9824.0
NOTCH3 -9867.0
H3C3 -9982.0
MIR206 -10323.0
MIR181C -10589.0
SIRT6 -10688.0
H2BC9 -10890.5
H3C7 -10890.5


REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION

REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION
738
set REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION
setSize 68
pANOVA 0.0216
s.dist 0.161
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AC14 10039
H2BC6 9804
H4C9 9566
H4C5 9308
H4C6 9192
H2BC14 9173
H2AC4 8927
H2BC4 8612
HDAC1 8575
H2BC12 8544
H2AC6 8154
MTA2 7863
H3C6 7745
H2BC15 7521
H2AJ 7388
CHD3 7121
H4C16 7045
H2BC13 6942
GATAD2A 6357
H3C1 6146

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AC14 10039.0
H2BC6 9804.0
H4C9 9566.0
H4C5 9308.0
H4C6 9192.0
H2BC14 9173.0
H2AC4 8927.0
H2BC4 8612.0
HDAC1 8575.0
H2BC12 8544.0
H2AC6 8154.0
MTA2 7863.0
H3C6 7745.0
H2BC15 7521.0
H2AJ 7388.0
CHD3 7121.0
H4C16 7045.0
H2BC13 6942.0
GATAD2A 6357.0
H3C1 6146.0
H4C8 6011.0
CBX3 5319.0
MBD3 5260.0
H4C3 4600.0
H3C4 4214.0
MTA3 4098.0
H4C4 3780.0
TTF1 3450.0
H2BC26 3341.0
H3-3B 3307.0
H4C1 2954.0
HDAC2 2921.0
H2AZ2 2797.0
MTA1 2479.0
H3C2 2089.0
EHMT2 1174.0
H2AC7 427.5
H2BC7 427.5
H3-3A -484.0
H2AC20 -868.0
CHD4 -1019.0
H2BC21 -1063.0
ERCC6 -1070.0
H2BC17 -1228.0
H2BC5 -1467.0
H2BC8 -1568.0
GATAD2B -2140.0
H3C10 -2185.0
H2BC1 -2654.0
H4C13 -3757.0
H4C12 -4032.0
H3C12 -4347.0
H4C11 -4396.0
H4C2 -4924.0
H3C11 -4941.0
H2AC18 -5374.5
H2AC19 -5374.5
H2AC8 -6437.0
H2BC10 -6470.0
H2AZ1 -7039.0
H2BC3 -7881.0
H2BC11 -8289.0
RBBP4 -8805.0
H2AX -9438.0
H3C8 -9824.0
H3C3 -9982.0
H2BC9 -10890.5
H3C7 -10890.5


REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
84
set REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS
setSize 42
pANOVA 0.0217
s.dist -0.205
p.adjustANOVA 0.688



Top enriched genes

Top 20 genes
GeneID Gene Rank
KCNA10 -10858
KCNH6 -9340
KCNA5 -9255
KCNG4 -8955
KCND3 -8172
KCNG3 -7966
KCND2 -6939
KCNF1 -6893
KCNA7 -6570
KCNA3 -6546
KCNAB1 -6460
KCNQ4 -5975
KCNH8 -5218
KCNC4 -5079
KCNG2 -5076
KCNB1 -4994
KCNH1 -4868
KCNA6 -4591
KCNC1 -4564
KCNA1 -4366

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
KCNA10 -10858
KCNH6 -9340
KCNA5 -9255
KCNG4 -8955
KCND3 -8172
KCNG3 -7966
KCND2 -6939
KCNF1 -6893
KCNA7 -6570
KCNA3 -6546
KCNAB1 -6460
KCNQ4 -5975
KCNH8 -5218
KCNC4 -5079
KCNG2 -5076
KCNB1 -4994
KCNH1 -4868
KCNA6 -4591
KCNC1 -4564
KCNA1 -4366
KCNC3 -3796
KCNH2 -3659
KCNH3 -3213
KCNG1 -3017
KCNS2 -2621
KCNQ3 -2363
KCNQ5 -1807
KCNH4 -981
KCNQ1 -835
KCNA2 -663
KCNQ2 -517
KCNH5 93
KCNA4 666
KCNS1 847
KCNH7 1369
KCNS3 1386
KCNC2 2242
KCNAB3 2774
KCNB2 2826
KCNV1 6617
KCNV2 6631
KCNAB2 7634


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.2.0                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gtools_3.9.5                                       
##  [6] tibble_3.2.1                                       
##  [7] dplyr_1.1.4                                        
##  [8] echarts4r_0.4.5                                    
##  [9] png_0.1-8                                          
## [10] gridExtra_2.3                                      
## [11] missMethyl_1.36.0                                  
## [12] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [13] beeswarm_0.4.0                                     
## [14] kableExtra_1.3.4                                   
## [15] gplots_3.1.3                                       
## [16] mitch_1.15.0                                       
## [17] tictoc_1.2                                         
## [18] HGNChelper_0.8.1                                   
## [19] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [20] IlluminaHumanMethylation450kmanifest_0.4.0         
## [21] minfi_1.48.0                                       
## [22] bumphunter_1.44.0                                  
## [23] locfit_1.5-9.8                                     
## [24] iterators_1.0.14                                   
## [25] foreach_1.5.2                                      
## [26] Biostrings_2.70.1                                  
## [27] XVector_0.42.0                                     
## [28] SummarizedExperiment_1.32.0                        
## [29] Biobase_2.62.0                                     
## [30] MatrixGenerics_1.14.0                              
## [31] matrixStats_1.2.0                                  
## [32] GenomicRanges_1.54.1                               
## [33] GenomeInfoDb_1.38.2                                
## [34] IRanges_2.36.0                                     
## [35] S4Vectors_0.40.2                                   
## [36] BiocGenerics_0.48.1                                
## [37] eulerr_7.0.0                                       
## [38] limma_3.58.1                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.2              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.3            preprocessCore_1.64.0    
##   [7] XML_3.99-0.16             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.8               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.8                httpuv_1.6.13            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.3             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.6                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] webshot_0.5.5             illuminaio_0.44.0        
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.8           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.3           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] SparseArray_1.2.2         xfun_0.41                
##  [55] HDF5Array_1.30.0          withr_2.5.2              
##  [57] fastmap_1.1.1             rhdf5filters_1.14.1      
##  [59] fansi_1.0.6               openssl_2.1.1            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.58.0           
##  [67] RSQLite_2.3.4             utf8_1.2.4               
##  [69] tidyr_1.3.0               generics_0.1.3           
##  [71] data.table_1.14.10        rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.4         S4Arrays_1.2.0           
##  [77] ggstats_0.5.1             pkgconfig_2.0.3          
##  [79] gtable_0.3.4              blob_1.2.4               
##  [81] siggenes_1.76.0           htmltools_0.5.7          
##  [83] scales_1.3.0              rstudioapi_0.15.0        
##  [85] knitr_1.45                tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-163             
##  [89] curl_5.2.0                org.Hs.eg.db_3.18.0      
##  [91] cachem_1.0.8              rhdf5_2.46.1             
##  [93] stringr_1.5.1             KernSmooth_2.23-22       
##  [95] AnnotationDbi_1.64.1      restfulr_0.0.15          
##  [97] GEOquery_2.70.0           pillar_1.9.0             
##  [99] grid_4.3.2                reshape_0.8.9            
## [101] vctrs_0.6.5               promises_1.2.1           
## [103] dbplyr_2.4.0              xtable_1.8-4             
## [105] evaluate_0.23             readr_2.1.4              
## [107] GenomicFeatures_1.54.1    cli_3.6.2                
## [109] compiler_4.3.2            Rsamtools_2.18.0         
## [111] rlang_1.1.2               crayon_1.5.2             
## [113] rngtools_1.5.2            nor1mix_1.3-2            
## [115] mclust_6.0.1              plyr_1.8.9               
## [117] stringi_1.8.3             viridisLite_0.4.2        
## [119] BiocParallel_1.36.0       munsell_0.5.0            
## [121] Matrix_1.6-1.1            hms_1.1.3                
## [123] sparseMatrixStats_1.14.0  bit64_4.0.5              
## [125] Rhdf5lib_1.24.1           KEGGREST_1.42.0          
## [127] statmod_1.5.0             shiny_1.8.0              
## [129] highr_0.10                memoise_2.0.1            
## [131] bslib_0.6.1               bit_4.0.5

END of report