Mitch Report

date generated: 2024-01-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
A1BG	0.0053106
A1BG-AS1	0.0024687
A1CF	0.0002532
A2M	0.0034872
A2M-AS1	0.0099358
A2ML1	0.0062461

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	1654
num_genes_in_profile	22007
duplicated_genes_present	0
num_profile_genes_in_sets	10383
num_profile_genes_not_in_sets	11624

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: c2.cp.reactome.v2023.1.Hs.symbols.gmt

Gene set metrics

	Gene sets metrics
num_genesets	1654
num_genesets_excluded	365
num_genesets_included	1289

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME RNA POLYMERASE II TRANSCRIPTION	1336	8.52e-11	-0.1060	1.40e-07
REACTOME CELL CYCLE	666	2.83e-09	-0.1350	2.32e-06
REACTOME CELL CYCLE MITOTIC	539	1.70e-08	-0.1420	7.86e-06
REACTOME M PHASE	398	1.92e-08	-0.1640	7.86e-06
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	121	9.19e-07	-0.2580	3.02e-04
REACTOME ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION	62	4.37e-06	-0.3370	9.81e-04
REACTOME DNA REPLICATION	178	4.76e-06	-0.1990	9.81e-04
REACTOME MEIOTIC RECOMBINATION	80	4.78e-06	-0.2960	9.81e-04
REACTOME FORMATION OF THE CORNIFIED ENVELOPE	125	5.73e-06	0.2350	1.05e-03
REACTOME CELL CYCLE CHECKPOINTS	284	1.00e-05	-0.1520	1.51e-03
REACTOME ESTROGEN DEPENDENT GENE EXPRESSION	140	1.22e-05	-0.2140	1.51e-03
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE	118	1.23e-05	-0.2330	1.51e-03
REACTOME CONDENSATION OF PROPHASE CHROMOSOMES	66	1.28e-05	-0.3110	1.51e-03
REACTOME DNA REPLICATION PRE INITIATION	150	1.28e-05	-0.2060	1.51e-03
REACTOME DNA METHYLATION	58	1.45e-05	-0.3290	1.57e-03
REACTOME B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	84	1.60e-05	-0.2720	1.57e-03
REACTOME PRC2 METHYLATES HISTONES AND DNA	65	1.62e-05	-0.3090	1.57e-03
REACTOME RNA POLYMERASE I PROMOTER ESCAPE	83	1.92e-05	-0.2710	1.76e-03
REACTOME SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	60	2.46e-05	-0.3150	2.13e-03
REACTOME ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	59	2.74e-05	-0.3160	2.23e-03
REACTOME TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	83	2.86e-05	-0.2660	2.23e-03
REACTOME CELLULAR SENESCENCE	189	3.19e-05	-0.1750	2.38e-03
REACTOME ESR MEDIATED SIGNALING	210	3.96e-05	-0.1650	2.83e-03
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1	229	5.89e-05	-0.1540	4.03e-03
REACTOME DNA REPAIR	321	6.38e-05	-0.1300	4.10e-03
REACTOME NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	100	6.63e-05	-0.2310	4.10e-03
REACTOME DISEASES OF PROGRAMMED CELL DEATH	96	6.74e-05	-0.2350	4.10e-03
REACTOME MEIOSIS	110	7.55e-05	-0.2180	4.42e-03
REACTOME HCMV LATE EVENTS	110	7.99e-05	-0.2180	4.52e-03
REACTOME MITOTIC PROPHASE	134	8.45e-05	-0.1970	4.62e-03
REACTOME G2 M CHECKPOINTS	162	9.11e-05	-0.1780	4.83e-03
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	222	9.65e-05	-0.1520	4.89e-03
REACTOME KERATINIZATION	210	9.84e-05	0.1560	4.89e-03
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	90	1.18e-04	-0.2350	5.70e-03
REACTOME TRANSCRIPTIONAL REGULATION BY SMALL RNAS	100	1.60e-04	-0.2180	7.26e-03
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	113	1.63e-04	-0.2050	7.26e-03
REACTOME CILIUM ASSEMBLY	190	1.64e-04	-0.1590	7.26e-03
REACTOME FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	85	1.99e-04	-0.2330	8.61e-03
REACTOME REPRODUCTION	136	2.36e-04	-0.1830	9.95e-03
REACTOME SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	104	2.97e-04	-0.2050	1.22e-02
REACTOME HCMV EARLY EVENTS	128	3.31e-04	-0.1840	1.33e-02
REACTOME HCMV INFECTION	152	3.42e-04	-0.1680	1.34e-02
REACTOME RHO GTPASES ACTIVATE PKNS	86	3.54e-04	-0.2230	1.35e-02
REACTOME INFECTIOUS DISEASE	910	3.61e-04	-0.0697	1.35e-02
REACTOME METABOLISM OF RNA	675	3.73e-04	-0.0803	1.36e-02
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	66	4.65e-04	-0.2490	1.66e-02
REACTOME POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	98	4.97e-04	-0.2040	1.74e-02
REACTOME EPIGENETIC REGULATION OF GENE EXPRESSION	138	5.47e-04	-0.1700	1.87e-02
REACTOME MITOTIC PROMETAPHASE	194	6.44e-04	-0.1420	2.16e-02
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	68	8.16e-04	-0.2350	2.68e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME RNA POLYMERASE II TRANSCRIPTION	1336	8.52e-11	-1.06e-01	1.40e-07
REACTOME CELL CYCLE	666	2.83e-09	-1.35e-01	2.32e-06
REACTOME CELL CYCLE MITOTIC	539	1.70e-08	-1.42e-01	7.86e-06
REACTOME M PHASE	398	1.92e-08	-1.64e-01	7.86e-06
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	121	9.19e-07	-2.58e-01	3.02e-04
REACTOME ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION	62	4.37e-06	-3.37e-01	9.81e-04
REACTOME DNA REPLICATION	178	4.76e-06	-1.99e-01	9.81e-04
REACTOME MEIOTIC RECOMBINATION	80	4.78e-06	-2.96e-01	9.81e-04
REACTOME FORMATION OF THE CORNIFIED ENVELOPE	125	5.73e-06	2.35e-01	1.05e-03
REACTOME CELL CYCLE CHECKPOINTS	284	1.00e-05	-1.52e-01	1.51e-03
REACTOME ESTROGEN DEPENDENT GENE EXPRESSION	140	1.22e-05	-2.14e-01	1.51e-03
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE	118	1.23e-05	-2.33e-01	1.51e-03
REACTOME CONDENSATION OF PROPHASE CHROMOSOMES	66	1.28e-05	-3.11e-01	1.51e-03
REACTOME DNA REPLICATION PRE INITIATION	150	1.28e-05	-2.06e-01	1.51e-03
REACTOME DNA METHYLATION	58	1.45e-05	-3.29e-01	1.57e-03
REACTOME B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	84	1.60e-05	-2.72e-01	1.57e-03
REACTOME PRC2 METHYLATES HISTONES AND DNA	65	1.62e-05	-3.09e-01	1.57e-03
REACTOME RNA POLYMERASE I PROMOTER ESCAPE	83	1.92e-05	-2.71e-01	1.76e-03
REACTOME SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	60	2.46e-05	-3.15e-01	2.13e-03
REACTOME ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	59	2.74e-05	-3.16e-01	2.23e-03
REACTOME TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	83	2.86e-05	-2.66e-01	2.23e-03
REACTOME CELLULAR SENESCENCE	189	3.19e-05	-1.75e-01	2.38e-03
REACTOME ESR MEDIATED SIGNALING	210	3.96e-05	-1.65e-01	2.83e-03
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1	229	5.89e-05	-1.54e-01	4.03e-03
REACTOME DNA REPAIR	321	6.38e-05	-1.30e-01	4.10e-03
REACTOME NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	100	6.63e-05	-2.31e-01	4.10e-03
REACTOME DISEASES OF PROGRAMMED CELL DEATH	96	6.74e-05	-2.35e-01	4.10e-03
REACTOME MEIOSIS	110	7.55e-05	-2.18e-01	4.42e-03
REACTOME HCMV LATE EVENTS	110	7.99e-05	-2.18e-01	4.52e-03
REACTOME MITOTIC PROPHASE	134	8.45e-05	-1.97e-01	4.62e-03
REACTOME G2 M CHECKPOINTS	162	9.11e-05	-1.78e-01	4.83e-03
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	222	9.65e-05	-1.52e-01	4.89e-03
REACTOME KERATINIZATION	210	9.84e-05	1.56e-01	4.89e-03
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	90	1.18e-04	-2.35e-01	5.70e-03
REACTOME TRANSCRIPTIONAL REGULATION BY SMALL RNAS	100	1.60e-04	-2.18e-01	7.26e-03
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	113	1.63e-04	-2.05e-01	7.26e-03
REACTOME CILIUM ASSEMBLY	190	1.64e-04	-1.59e-01	7.26e-03
REACTOME FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	85	1.99e-04	-2.33e-01	8.61e-03
REACTOME REPRODUCTION	136	2.36e-04	-1.83e-01	9.95e-03
REACTOME SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	104	2.97e-04	-2.05e-01	1.22e-02
REACTOME HCMV EARLY EVENTS	128	3.31e-04	-1.84e-01	1.33e-02
REACTOME HCMV INFECTION	152	3.42e-04	-1.68e-01	1.34e-02
REACTOME RHO GTPASES ACTIVATE PKNS	86	3.54e-04	-2.23e-01	1.35e-02
REACTOME INFECTIOUS DISEASE	910	3.61e-04	-6.97e-02	1.35e-02
REACTOME METABOLISM OF RNA	675	3.73e-04	-8.03e-02	1.36e-02
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	66	4.65e-04	-2.49e-01	1.66e-02
REACTOME POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	98	4.97e-04	-2.04e-01	1.74e-02
REACTOME EPIGENETIC REGULATION OF GENE EXPRESSION	138	5.47e-04	-1.70e-01	1.87e-02
REACTOME MITOTIC PROMETAPHASE	194	6.44e-04	-1.42e-01	2.16e-02
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	68	8.16e-04	-2.35e-01	2.68e-02
REACTOME RNA POLYMERASE I TRANSCRIPTION	102	8.64e-04	-1.91e-01	2.78e-02
REACTOME DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	76	1.27e-03	-2.14e-01	4.01e-02
REACTOME G2 M DNA DAMAGE CHECKPOINT	90	1.41e-03	-1.95e-01	4.29e-02
REACTOME MITOTIC G2 G2 M PHASES	194	1.41e-03	-1.33e-01	4.29e-02
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE	277	1.47e-03	-1.11e-01	4.37e-02
REACTOME RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	52	1.50e-03	-2.55e-01	4.37e-02
REACTOME SIGNALING BY NOTCH	234	1.52e-03	-1.20e-01	4.37e-02
REACTOME SIGNALING BY NUCLEAR RECEPTORS	283	1.55e-03	-1.09e-01	4.40e-02
REACTOME UCH PROTEINASES	99	1.60e-03	-1.84e-01	4.44e-02
REACTOME MITOTIC METAPHASE AND ANAPHASE	228	1.65e-03	-1.21e-01	4.49e-02
REACTOME INTERLEUKIN 1 SIGNALING	110	1.67e-03	-1.73e-01	4.49e-02
REACTOME SIGNALING BY WNT	318	1.80e-03	-1.02e-01	4.76e-02
REACTOME RHO GTPASE EFFECTORS	305	1.95e-03	-1.03e-01	5.07e-02
REACTOME ABC TRANSPORTER DISORDERS	76	2.11e-03	-2.04e-01	5.43e-02
REACTOME INHIBITION OF DNA RECOMBINATION AT TELOMERE	63	2.32e-03	-2.22e-01	5.87e-02
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	112	2.41e-03	-1.66e-01	5.98e-02
REACTOME TCR SIGNALING	113	2.85e-03	-1.62e-01	6.99e-02
REACTOME PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	93	3.15e-03	-1.77e-01	7.53e-02
REACTOME ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	93	3.17e-03	-1.77e-01	7.53e-02
REACTOME G1 S DNA DAMAGE CHECKPOINTS	67	3.43e-03	-2.07e-01	8.04e-02
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	3.74e-03	-1.89e-01	8.65e-02
REACTOME BASE EXCISION REPAIR AP SITE FORMATION	59	3.81e-03	-2.18e-01	8.70e-02
REACTOME CELLULAR RESPONSES TO STIMULI	779	3.96e-03	-6.07e-02	8.91e-02
REACTOME DEUBIQUITINATION	260	4.63e-03	-1.02e-01	1.01e-01
REACTOME SUMOYLATION	179	4.73e-03	-1.22e-01	1.01e-01
REACTOME CREATINE METABOLISM	9	4.74e-03	5.44e-01	1.01e-01
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	1356	4.77e-03	-4.57e-02	1.01e-01
REACTOME GENE SILENCING BY RNA	133	4.81e-03	-1.42e-01	1.01e-01
REACTOME UB SPECIFIC PROCESSING PROTEASES	187	4.89e-03	-1.19e-01	1.02e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX2	117	5.21e-03	-1.50e-01	1.06e-01
REACTOME NONHOMOLOGOUS END JOINING NHEJ	64	5.24e-03	-2.02e-01	1.06e-01
REACTOME MUSCLE CONTRACTION	197	5.42e-03	1.15e-01	1.08e-01
REACTOME SURFACTANT METABOLISM	28	5.51e-03	3.03e-01	1.09e-01
REACTOME MEIOTIC SYNAPSIS	73	5.73e-03	-1.87e-01	1.11e-01
REACTOME CHYLOMICRON REMODELING	10	5.77e-03	5.04e-01	1.11e-01
REACTOME DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	60	5.94e-03	-2.05e-01	1.13e-01
REACTOME FC EPSILON RECEPTOR FCERI SIGNALING	127	5.96e-03	-1.41e-01	1.13e-01
REACTOME HDACS DEACETYLATE HISTONES	85	6.70e-03	-1.70e-01	1.25e-01
REACTOME CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	6.99e-03	-1.70e-01	1.29e-01
REACTOME SIGNALING BY GPCR	673	7.40e-03	6.05e-02	1.35e-01
REACTOME CHROMOSOME MAINTENANCE	130	7.64e-03	-1.35e-01	1.37e-01
REACTOME MITOTIC G1 PHASE AND G1 S TRANSITION	145	7.65e-03	-1.28e-01	1.37e-01
REACTOME ORGANIC CATION TRANSPORT	10	7.83e-03	-4.86e-01	1.38e-01
REACTOME DEGRADATION OF GLI1 BY THE PROTEASOME	59	8.03e-03	-2.00e-01	1.40e-01
REACTOME REGULATION OF RAS BY GAPS	66	8.84e-03	-1.86e-01	1.53e-01
REACTOME HATS ACETYLATE HISTONES	129	9.02e-03	-1.33e-01	1.54e-01
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	9.26e-03	-1.96e-01	1.57e-01
REACTOME DEGRADATION OF DVL	56	9.90e-03	-1.99e-01	1.65e-01
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	16	9.97e-03	3.72e-01	1.65e-01
REACTOME BASE EXCISION REPAIR	87	1.02e-02	-1.59e-01	1.66e-01
REACTOME COENZYME A BIOSYNTHESIS	8	1.02e-02	5.25e-01	1.66e-01
REACTOME DNA DAMAGE RECOGNITION IN GG NER	36	1.03e-02	-2.47e-01	1.66e-01
REACTOME DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	1.09e-02	-1.62e-01	1.73e-01
REACTOME S PHASE	159	1.10e-02	-1.17e-01	1.73e-01
REACTOME DEGRADATION OF AXIN	54	1.12e-02	-1.99e-01	1.73e-01
REACTOME TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	109	1.13e-02	-1.41e-01	1.73e-01
REACTOME STRIATED MUSCLE CONTRACTION	35	1.14e-02	2.47e-01	1.73e-01
REACTOME MAPK6 MAPK4 SIGNALING	91	1.14e-02	-1.53e-01	1.73e-01
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	20	1.19e-02	-3.25e-01	1.80e-01
REACTOME SIGNALING BY INTERLEUKINS	444	1.27e-02	-6.90e-02	1.85e-01
REACTOME NEDDYLATION	235	1.28e-02	-9.43e-02	1.85e-01
REACTOME SENSORY PERCEPTION OF TASTE	47	1.29e-02	2.10e-01	1.85e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	99	1.29e-02	-1.45e-01	1.85e-01
REACTOME GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	81	1.30e-02	-1.60e-01	1.85e-01
REACTOME CREATION OF C4 AND C2 ACTIVATORS	14	1.31e-02	3.83e-01	1.85e-01
REACTOME TNFR2 NON CANONICAL NF KB PATHWAY	96	1.32e-02	-1.46e-01	1.85e-01
REACTOME STABILIZATION OF P53	56	1.32e-02	-1.91e-01	1.85e-01
REACTOME TELOMERE MAINTENANCE	106	1.33e-02	-1.39e-01	1.85e-01
REACTOME DNA DOUBLE STRAND BREAK REPAIR	162	1.35e-02	-1.12e-01	1.85e-01
REACTOME SEPARATION OF SISTER CHROMATIDS	184	1.35e-02	-1.06e-01	1.85e-01
REACTOME METALLOPROTEASE DUBS	36	1.37e-02	-2.37e-01	1.86e-01
REACTOME ION CHANNEL TRANSPORT	172	1.40e-02	1.09e-01	1.88e-01
REACTOME REGULATION OF PTEN STABILITY AND ACTIVITY	67	1.42e-02	-1.73e-01	1.90e-01
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	263	1.53e-02	-8.69e-02	2.02e-01
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS	8	1.56e-02	-4.94e-01	2.02e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	54	1.56e-02	-1.90e-01	2.02e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	10	1.56e-02	-4.42e-01	2.02e-01
REACTOME RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	58	1.57e-02	-1.83e-01	2.02e-01
REACTOME DNA DOUBLE STRAND BREAK RESPONSE	74	1.59e-02	-1.62e-01	2.02e-01
REACTOME REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	54	1.64e-02	-1.89e-01	2.07e-01
REACTOME TRP CHANNELS	27	1.67e-02	2.66e-01	2.09e-01
REACTOME HOMOLOGY DIRECTED REPAIR	132	1.69e-02	-1.20e-01	2.09e-01
REACTOME ASPIRIN ADME	42	1.69e-02	-2.13e-01	2.09e-01
REACTOME GLUCURONIDATION	23	1.72e-02	-2.87e-01	2.10e-01
REACTOME PROTEIN UBIQUITINATION	76	1.78e-02	-1.57e-01	2.17e-01
REACTOME E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	58	1.80e-02	-1.80e-01	2.18e-01
REACTOME ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	1.85e-02	-3.30e-01	2.21e-01
REACTOME HDMS DEMETHYLATE HISTONES	40	1.86e-02	-2.15e-01	2.22e-01
REACTOME REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	72	1.94e-02	-1.59e-01	2.29e-01
REACTOME SIGNALING BY ERBB4	57	2.00e-02	-1.78e-01	2.34e-01
REACTOME REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	84	2.01e-02	-1.47e-01	2.34e-01
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	679	2.10e-02	-5.19e-02	2.42e-01
REACTOME INITIAL TRIGGERING OF COMPLEMENT	21	2.10e-02	2.91e-01	2.42e-01
REACTOME MITOCHONDRIAL TRANSLATION	93	2.16e-02	-1.38e-01	2.47e-01
REACTOME NUCLEOTIDE EXCISION REPAIR	107	2.21e-02	-1.28e-01	2.50e-01
REACTOME AURKA ACTIVATION BY TPX2	69	2.28e-02	-1.58e-01	2.56e-01
REACTOME SYNTHESIS OF DNA	119	2.34e-02	-1.20e-01	2.61e-01
REACTOME CONDENSATION OF PROMETAPHASE CHROMOSOMES	11	2.41e-02	-3.93e-01	2.65e-01
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	11	2.41e-02	-3.93e-01	2.65e-01
REACTOME NEGATIVE REGULATION OF NOTCH4 SIGNALING	53	2.43e-02	-1.79e-01	2.65e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	101	2.46e-02	1.29e-01	2.65e-01
REACTOME ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	2.48e-02	-1.64e-01	2.65e-01
REACTOME TRNA AMINOACYLATION	40	2.48e-02	-2.05e-01	2.65e-01
REACTOME ONCOGENE INDUCED SENESCENCE	35	2.48e-02	-2.19e-01	2.65e-01
REACTOME PLASMA LIPOPROTEIN REMODELING	33	2.56e-02	2.25e-01	2.71e-01
REACTOME SIGNALING BY ROBO RECEPTORS	206	2.63e-02	-8.98e-02	2.74e-01
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	14	2.65e-02	-3.42e-01	2.74e-01
REACTOME MRNA SPLICING	197	2.66e-02	-9.16e-02	2.74e-01
REACTOME MOLECULES ASSOCIATED WITH ELASTIC FIBRES	37	2.67e-02	2.11e-01	2.74e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN	70	2.67e-02	-1.53e-01	2.74e-01
REACTOME HEDGEHOG OFF STATE	111	2.69e-02	-1.22e-01	2.75e-01
REACTOME HEDGEHOG LIGAND BIOGENESIS	64	2.84e-02	-1.58e-01	2.86e-01
REACTOME HIV INFECTION	223	2.84e-02	-8.52e-02	2.86e-01
REACTOME THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	23	2.89e-02	2.63e-01	2.90e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	2.95e-02	-2.68e-01	2.94e-01
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	122	3.15e-02	-1.13e-01	3.12e-01
REACTOME THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	159	3.19e-02	-9.86e-02	3.13e-01
REACTOME INTERFERON GAMMA SIGNALING	88	3.21e-02	1.32e-01	3.13e-01
REACTOME ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA	5	3.22e-02	-5.53e-01	3.13e-01
REACTOME AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	3.26e-02	-1.68e-01	3.15e-01
REACTOME INTERLEUKIN 1 FAMILY SIGNALING	146	3.31e-02	-1.02e-01	3.18e-01
REACTOME PKMTS METHYLATE HISTONE LYSINES	64	3.33e-02	-1.54e-01	3.18e-01
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	12	3.39e-02	3.54e-01	3.22e-01
REACTOME DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15	8	3.42e-02	-4.32e-01	3.23e-01
REACTOME FASL CD95L SIGNALING	5	3.46e-02	-5.46e-01	3.25e-01
REACTOME STIMULI SENSING CHANNELS	100	3.51e-02	1.22e-01	3.27e-01
REACTOME ERK MAPK TARGETS	20	3.52e-02	-2.72e-01	3.27e-01
REACTOME ADAPTIVE IMMUNE SYSTEM	729	3.55e-02	-4.57e-02	3.27e-01
REACTOME MYD88 INDEPENDENT TLR4 CASCADE	103	3.59e-02	-1.20e-01	3.30e-01
REACTOME CHYLOMICRON ASSEMBLY	10	3.65e-02	3.82e-01	3.30e-01
REACTOME PREGNENOLONE BIOSYNTHESIS	12	3.66e-02	-3.48e-01	3.30e-01
REACTOME TOLL LIKE RECEPTOR CASCADES	158	3.66e-02	-9.63e-02	3.30e-01
REACTOME PROGRAMMED CELL DEATH	204	3.68e-02	-8.48e-02	3.30e-01
REACTOME SIGNALING BY ERBB2 IN CANCER	26	3.75e-02	-2.36e-01	3.35e-01
REACTOME INFLUENZA INFECTION	149	3.83e-02	-9.83e-02	3.39e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	49	3.84e-02	-1.71e-01	3.39e-01
REACTOME TRANSLATION	278	3.96e-02	-7.17e-02	3.46e-01
REACTOME PYRIMIDINE SALVAGE	10	3.96e-02	3.76e-01	3.46e-01
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	19	4.06e-02	2.71e-01	3.51e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS	12	4.06e-02	3.41e-01	3.51e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	106	4.11e-02	-1.15e-01	3.54e-01
REACTOME NUCLEAR SIGNALING BY ERBB4	32	4.19e-02	-2.08e-01	3.56e-01
REACTOME MISCELLANEOUS SUBSTRATES	12	4.19e-02	3.39e-01	3.56e-01
REACTOME MUSCARINIC ACETYLCHOLINE RECEPTORS	5	4.21e-02	5.25e-01	3.56e-01
REACTOME REGULATION OF EXPRESSION OF SLITS AND ROBOS	161	4.28e-02	-9.25e-02	3.60e-01
REACTOME DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A	5	4.30e-02	5.23e-01	3.60e-01
REACTOME TYPE I HEMIDESMOSOME ASSEMBLY	11	4.33e-02	3.52e-01	3.61e-01
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	688	4.44e-02	-4.49e-02	3.69e-01
REACTOME FLT3 SIGNALING IN DISEASE	28	4.55e-02	-2.18e-01	3.70e-01
REACTOME HOST INTERACTIONS OF HIV FACTORS	127	4.59e-02	-1.03e-01	3.70e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	4.59e-02	-1.70e-01	3.70e-01
REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	23	4.63e-02	2.40e-01	3.70e-01
REACTOME PLATELET CALCIUM HOMEOSTASIS	27	4.66e-02	2.21e-01	3.70e-01
REACTOME TOLL LIKE RECEPTOR 9 TLR9 CASCADE	100	4.67e-02	-1.15e-01	3.70e-01
REACTOME FCERI MEDIATED NF KB ACTIVATION	78	4.67e-02	-1.30e-01	3.70e-01
REACTOME VISUAL PHOTOTRANSDUCTION	93	4.68e-02	1.19e-01	3.70e-01
REACTOME PHASE 4 RESTING MEMBRANE POTENTIAL	19	4.71e-02	2.63e-01	3.70e-01
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	20	4.73e-02	2.56e-01	3.70e-01
REACTOME PI 3K CASCADE FGFR4	19	4.74e-02	2.63e-01	3.70e-01
REACTOME THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	77	4.76e-02	-1.31e-01	3.70e-01
REACTOME TRANSPORT OF SMALL MOLECULES	697	4.77e-02	4.40e-02	3.70e-01
REACTOME GPCR LIGAND BINDING	444	4.78e-02	5.48e-02	3.70e-01
REACTOME RMTS METHYLATE HISTONE ARGININES	72	4.85e-02	-1.34e-01	3.71e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	4.90e-02	-1.29e-01	3.71e-01
REACTOME INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	18	4.91e-02	-2.68e-01	3.71e-01
REACTOME HIV LIFE CYCLE	145	4.93e-02	-9.46e-02	3.71e-01
REACTOME G ALPHA I SIGNALLING EVENTS	304	4.96e-02	6.55e-02	3.71e-01
REACTOME WNT MEDIATED ACTIVATION OF DVL	8	4.98e-02	-4.01e-01	3.71e-01
REACTOME FATTY ACIDS	15	4.99e-02	2.92e-01	3.71e-01
REACTOME TRIGLYCERIDE METABOLISM	35	5.00e-02	1.91e-01	3.71e-01
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	91	5.01e-02	-1.19e-01	3.71e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	16	5.01e-02	-2.83e-01	3.71e-01
REACTOME DRUG ADME	103	5.17e-02	-1.11e-01	3.81e-01
REACTOME INTERLEUKIN 7 SIGNALING	31	5.22e-02	-2.01e-01	3.83e-01
REACTOME P75NTR REGULATES AXONOGENESIS	9	5.27e-02	3.73e-01	3.83e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	80	5.28e-02	-1.25e-01	3.83e-01
REACTOME CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	5.35e-02	3.53e-01	3.87e-01
REACTOME CARGO CONCENTRATION IN THE ER	32	5.41e-02	-1.97e-01	3.88e-01
REACTOME RRNA PROCESSING	192	5.42e-02	-8.06e-02	3.88e-01
REACTOME DEFECTIVE GALNT3 CAUSES HFTC	16	5.50e-02	2.77e-01	3.91e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX3	94	5.51e-02	-1.14e-01	3.91e-01
REACTOME SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	91	5.53e-02	-1.16e-01	3.91e-01
REACTOME TIGHT JUNCTION INTERACTIONS	29	5.55e-02	2.05e-01	3.91e-01
REACTOME SIGNALING BY NOTCH4	80	5.61e-02	-1.24e-01	3.94e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR4	14	5.63e-02	2.95e-01	3.94e-01
REACTOME FGFR1C LIGAND BINDING AND ACTIVATION	11	5.72e-02	3.31e-01	3.97e-01
REACTOME KEAP1 NFE2L2 PATHWAY	104	5.73e-02	-1.08e-01	3.97e-01
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	12	5.83e-02	3.16e-01	4.02e-01
REACTOME CLASS A 1 RHODOPSIN LIKE RECEPTORS	312	5.85e-02	6.23e-02	4.02e-01
REACTOME VLDL ASSEMBLY	5	5.91e-02	4.87e-01	4.04e-01
REACTOME RAS PROCESSING	22	5.93e-02	-2.32e-01	4.04e-01
REACTOME SENSORY PROCESSING OF SOUND	72	5.96e-02	1.28e-01	4.04e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	22	6.03e-02	-2.31e-01	4.07e-01
REACTOME INDUCTION OF CELL CELL FUSION	12	6.07e-02	3.13e-01	4.08e-01
REACTOME FGFR3 LIGAND BINDING AND ACTIVATION	12	6.08e-02	3.13e-01	4.08e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION	39	6.17e-02	1.73e-01	4.12e-01
REACTOME METABOLISM OF POLYAMINES	56	6.28e-02	-1.44e-01	4.18e-01
REACTOME ELASTIC FIBRE FORMATION	44	6.37e-02	1.62e-01	4.21e-01
REACTOME G ALPHA Q SIGNALLING EVENTS	206	6.41e-02	7.48e-02	4.21e-01
REACTOME DISEASES OF MISMATCH REPAIR MMR	5	6.41e-02	-4.78e-01	4.21e-01
REACTOME TRANSPORT AND SYNTHESIS OF PAPS	6	6.48e-02	4.35e-01	4.24e-01
REACTOME TOXICITY OF BOTULINUM TOXIN TYPE D BOTD	5	6.54e-02	4.76e-01	4.26e-01
REACTOME KILLING MECHANISMS	11	6.63e-02	-3.20e-01	4.30e-01
REACTOME HDL REMODELING	10	6.87e-02	3.32e-01	4.44e-01
REACTOME NEUROTRANSMITTER RELEASE CYCLE	48	6.96e-02	1.51e-01	4.48e-01
REACTOME MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	15	6.99e-02	-2.70e-01	4.48e-01
REACTOME GLYCOGEN SYNTHESIS	13	7.01e-02	-2.90e-01	4.48e-01
REACTOME DISEASES OF BASE EXCISION REPAIR	5	7.10e-02	4.66e-01	4.51e-01
REACTOME CELL JUNCTION ORGANIZATION	89	7.12e-02	1.11e-01	4.51e-01
REACTOME APOPTOSIS	173	7.30e-02	-7.90e-02	4.61e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY	19	7.42e-02	2.37e-01	4.67e-01
REACTOME SIGNALING BY PTK6	54	7.47e-02	-1.40e-01	4.68e-01
REACTOME MITOTIC SPINDLE CHECKPOINT	109	7.49e-02	-9.87e-02	4.68e-01
REACTOME INTRAFLAGELLAR TRANSPORT	50	7.53e-02	-1.45e-01	4.68e-01
REACTOME SHC1 EVENTS IN ERBB2 SIGNALING	22	7.60e-02	-2.19e-01	4.70e-01
REACTOME RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	47	7.63e-02	-1.49e-01	4.70e-01
REACTOME PI 3K CASCADE FGFR2	22	7.66e-02	2.18e-01	4.70e-01
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	15	7.69e-02	-2.64e-01	4.70e-01
REACTOME HISTIDINE CATABOLISM	8	7.73e-02	3.61e-01	4.70e-01
REACTOME ERKS ARE INACTIVATED	13	7.75e-02	-2.83e-01	4.70e-01
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	36	7.78e-02	-1.70e-01	4.70e-01
REACTOME NS1 MEDIATED EFFECTS ON HOST PATHWAYS	41	7.79e-02	-1.59e-01	4.70e-01
REACTOME HYDROLYSIS OF LPC	9	7.84e-02	3.39e-01	4.72e-01
REACTOME ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY	5	7.87e-02	-4.54e-01	4.72e-01
REACTOME INTERLEUKIN 18 SIGNALING	8	7.97e-02	3.58e-01	4.76e-01
REACTOME UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	8.06e-02	-3.04e-01	4.77e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	53	8.07e-02	1.39e-01	4.77e-01
REACTOME RESPIRATORY ELECTRON TRANSPORT	90	8.07e-02	-1.07e-01	4.77e-01
REACTOME PROPIONYL COA CATABOLISM	5	8.13e-02	-4.50e-01	4.79e-01
REACTOME DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	39	8.17e-02	-1.61e-01	4.79e-01
REACTOME ERBB2 REGULATES CELL MOTILITY	15	8.30e-02	-2.59e-01	4.82e-01
REACTOME CELLULAR RESPONSE TO CHEMICAL STRESS	188	8.30e-02	-7.33e-02	4.82e-01
REACTOME PHYSIOLOGICAL FACTORS	14	8.31e-02	-2.67e-01	4.82e-01
REACTOME RESOLUTION OF SISTER CHROMATID COHESION	120	8.39e-02	-9.14e-02	4.85e-01
REACTOME GENERATION OF SECOND MESSENGER MOLECULES	30	8.44e-02	-1.82e-01	4.86e-01
REACTOME PHASE 0 RAPID DEPOLARISATION	31	8.47e-02	1.79e-01	4.86e-01
REACTOME NCAM1 INTERACTIONS	41	8.54e-02	1.55e-01	4.89e-01
REACTOME HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	43	8.59e-02	-1.51e-01	4.90e-01
REACTOME COMMON PATHWAY OF FIBRIN CLOT FORMATION	21	8.72e-02	-2.16e-01	4.93e-01
REACTOME DISEASES OF DNA REPAIR	51	8.72e-02	-1.38e-01	4.93e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	129	8.77e-02	-8.71e-02	4.93e-01
REACTOME EICOSANOIDS	12	8.78e-02	2.85e-01	4.93e-01
REACTOME COMPLEX I BIOGENESIS	49	8.84e-02	-1.41e-01	4.96e-01
REACTOME PI5P REGULATES TP53 ACETYLATION	9	8.93e-02	-3.27e-01	4.97e-01
REACTOME SODIUM PROTON EXCHANGERS	7	8.93e-02	3.71e-01	4.97e-01
REACTOME RHO GTPASES ACTIVATE FORMINS	136	9.04e-02	-8.41e-02	5.01e-01
REACTOME APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	87	9.05e-02	-1.05e-01	5.01e-01
REACTOME ACROSOME REACTION AND SPERM OOCYTE MEMBRANE BINDING	6	9.15e-02	3.98e-01	5.03e-01
REACTOME INTERLEUKIN 17 SIGNALING	66	9.23e-02	-1.20e-01	5.03e-01
REACTOME FGFR2 LIGAND BINDING AND ACTIVATION	19	9.23e-02	2.23e-01	5.03e-01
REACTOME GLYCOLYSIS	70	9.34e-02	-1.16e-01	5.03e-01
REACTOME DISORDERS OF TRANSMEMBRANE TRANSPORTERS	170	9.36e-02	-7.45e-02	5.03e-01
REACTOME INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	198	9.37e-02	-6.91e-02	5.03e-01
REACTOME CHOLINE CATABOLISM	6	9.38e-02	3.95e-01	5.03e-01
REACTOME CLEC7A DECTIN 1 SIGNALING	97	9.38e-02	-9.85e-02	5.03e-01
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	32	9.41e-02	-1.71e-01	5.03e-01
REACTOME DECTIN 2 FAMILY	26	9.42e-02	1.90e-01	5.03e-01
REACTOME TRANSCRIPTIONAL REGULATION BY TP53	351	9.43e-02	-5.20e-02	5.03e-01
REACTOME ACTIVATION OF RAS IN B CELLS	5	9.73e-02	-4.28e-01	5.17e-01
REACTOME ORGANIC ANION TRANSPORTERS	10	9.89e-02	3.01e-01	5.22e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	17	9.89e-02	2.31e-01	5.22e-01
REACTOME SYNAPTIC ADHESION LIKE MOLECULES	19	9.92e-02	2.18e-01	5.22e-01
REACTOME CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	1.01e-01	-2.86e-01	5.27e-01
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	73	1.01e-01	-1.11e-01	5.27e-01
REACTOME PASSIVE TRANSPORT BY AQUAPORINS	13	1.01e-01	2.63e-01	5.27e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	1.03e-01	-1.23e-01	5.32e-01
REACTOME PI 3K CASCADE FGFR3	17	1.03e-01	2.28e-01	5.32e-01
REACTOME DEFECTIVE C1GALT1C1 CAUSES TNPS	16	1.03e-01	2.35e-01	5.32e-01
REACTOME WAX AND PLASMALOGEN BIOSYNTHESIS	5	1.04e-01	-4.20e-01	5.32e-01
REACTOME SUMOYLATION OF TRANSCRIPTION COFACTORS	43	1.04e-01	-1.43e-01	5.32e-01
REACTOME TRANSPORT OF ORGANIC ANIONS	10	1.05e-01	2.96e-01	5.37e-01
REACTOME HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	66	1.06e-01	-1.15e-01	5.37e-01
REACTOME SIGNALING BY FLT3 FUSION PROTEINS	19	1.06e-01	-2.14e-01	5.37e-01
REACTOME SIGNALING BY HEDGEHOG	148	1.06e-01	-7.69e-02	5.37e-01
REACTOME SNRNP ASSEMBLY	53	1.06e-01	-1.28e-01	5.37e-01
REACTOME NUCLEAR EVENTS MEDIATED BY NFE2L2	77	1.07e-01	-1.06e-01	5.37e-01
REACTOME PURINE CATABOLISM	17	1.07e-01	-2.26e-01	5.39e-01
REACTOME INTERLEUKIN 23 SIGNALING	9	1.09e-01	3.09e-01	5.45e-01
REACTOME IRS ACTIVATION	5	1.10e-01	4.13e-01	5.48e-01
REACTOME POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	1.11e-01	-1.84e-01	5.51e-01
REACTOME DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	61	1.11e-01	-1.18e-01	5.52e-01
REACTOME CYCLIN D ASSOCIATED EVENTS IN G1	46	1.12e-01	-1.36e-01	5.52e-01
REACTOME PCP CE PATHWAY	91	1.13e-01	-9.61e-02	5.58e-01
REACTOME SMAC XIAP REGULATED APOPTOTIC RESPONSE	7	1.14e-01	-3.45e-01	5.59e-01
REACTOME IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	17	1.14e-01	2.21e-01	5.59e-01
REACTOME SENSORY PERCEPTION	555	1.16e-01	3.91e-02	5.60e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	122	1.16e-01	8.25e-02	5.60e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	236	1.16e-01	5.94e-02	5.60e-01
REACTOME RAC3 GTPASE CYCLE	85	1.16e-01	-9.86e-02	5.60e-01
REACTOME LDL REMODELING	6	1.16e-01	3.70e-01	5.60e-01
REACTOME EICOSANOID LIGAND BINDING RECEPTORS	14	1.16e-01	2.42e-01	5.60e-01
REACTOME TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	26	1.17e-01	-1.78e-01	5.62e-01
REACTOME SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	21	1.19e-01	1.97e-01	5.68e-01
REACTOME HDR THROUGH SINGLE STRAND ANNEALING SSA	37	1.19e-01	-1.48e-01	5.68e-01
REACTOME MATURATION OF SARS COV 1 SPIKE PROTEIN	5	1.19e-01	4.02e-01	5.69e-01
REACTOME THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	1.21e-01	1.72e-01	5.72e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	29	1.21e-01	-1.66e-01	5.72e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	54	1.21e-01	-1.22e-01	5.72e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS	9	1.22e-01	-2.98e-01	5.72e-01
REACTOME PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	14	1.23e-01	-2.38e-01	5.76e-01
REACTOME SIGNAL AMPLIFICATION	33	1.23e-01	-1.55e-01	5.76e-01
REACTOME RHOBTB1 GTPASE CYCLE	22	1.24e-01	-1.90e-01	5.76e-01
REACTOME NUCLEAR ENVELOPE NE REASSEMBLY	74	1.24e-01	-1.03e-01	5.76e-01
REACTOME ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	10	1.25e-01	-2.80e-01	5.76e-01
REACTOME CHYLOMICRON CLEARANCE	5	1.25e-01	3.96e-01	5.76e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	17	1.25e-01	-2.15e-01	5.76e-01
REACTOME PYROPTOSIS	27	1.25e-01	-1.70e-01	5.76e-01
REACTOME BETA CATENIN INDEPENDENT WNT SIGNALING	145	1.27e-01	-7.34e-02	5.83e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE	5	1.28e-01	-3.93e-01	5.84e-01
REACTOME SARS COV 1 HOST INTERACTIONS	92	1.29e-01	-9.15e-02	5.89e-01
REACTOME CARDIAC CONDUCTION	125	1.30e-01	7.85e-02	5.90e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	74	1.30e-01	1.02e-01	5.91e-01
REACTOME TRNA PROCESSING	105	1.31e-01	-8.54e-02	5.91e-01
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	111	1.33e-01	-8.26e-02	5.97e-01
REACTOME OAS ANTIVIRAL RESPONSE	8	1.33e-01	-3.07e-01	5.97e-01
REACTOME OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS	8	1.33e-01	3.06e-01	5.97e-01
REACTOME SCAVENGING BY CLASS A RECEPTORS	19	1.33e-01	1.99e-01	5.97e-01
REACTOME SIGNALING BY LRP5 MUTANTS	6	1.35e-01	3.53e-01	5.97e-01
REACTOME SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	68	1.35e-01	-1.05e-01	5.97e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE	8	1.35e-01	3.05e-01	5.97e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	9	1.36e-01	2.87e-01	5.97e-01
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	17	1.37e-01	-2.08e-01	5.97e-01
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.37e-01	2.72e-01	5.97e-01
REACTOME REGULATION OF IFNG SIGNALING	14	1.37e-01	2.30e-01	5.97e-01
REACTOME PI 3K CASCADE FGFR1	21	1.37e-01	1.87e-01	5.97e-01
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	1.37e-01	2.59e-01	5.97e-01
REACTOME INTESTINAL ABSORPTION	5	1.37e-01	3.84e-01	5.97e-01
REACTOME INTERFERON ALPHA BETA SIGNALING	70	1.39e-01	1.02e-01	6.02e-01
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION	8	1.40e-01	3.02e-01	6.03e-01
REACTOME ACTIVATION OF C3 AND C5	6	1.40e-01	3.48e-01	6.03e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	1.40e-01	-1.91e-01	6.03e-01
REACTOME GABA RECEPTOR ACTIVATION	57	1.41e-01	-1.13e-01	6.04e-01
REACTOME PI3K AKT SIGNALING IN CANCER	103	1.41e-01	8.40e-02	6.04e-01
REACTOME INTEGRATION OF PROVIRUS	9	1.42e-01	-2.83e-01	6.08e-01
REACTOME CA DEPENDENT EVENTS	36	1.43e-01	1.41e-01	6.11e-01
REACTOME ERBB2 ACTIVATES PTK6 SIGNALING	13	1.44e-01	-2.34e-01	6.11e-01
REACTOME SENSORY PERCEPTION OF SALTY TASTE	6	1.44e-01	3.44e-01	6.11e-01
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	86	1.46e-01	-9.08e-02	6.15e-01
REACTOME SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	52	1.46e-01	1.17e-01	6.15e-01
REACTOME CELLULAR RESPONSE TO HYPOXIA	74	1.47e-01	-9.76e-02	6.17e-01
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	15	1.47e-01	2.16e-01	6.17e-01
REACTOME LEISHMANIA INFECTION	156	1.48e-01	-6.71e-02	6.19e-01
REACTOME ANTIMICROBIAL PEPTIDES	76	1.49e-01	9.58e-02	6.19e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	38	1.49e-01	1.35e-01	6.19e-01
REACTOME REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	9	1.49e-01	-2.78e-01	6.19e-01
REACTOME SYNTHESIS OF PG	8	1.50e-01	2.94e-01	6.19e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	89	1.51e-01	8.81e-02	6.19e-01
REACTOME HEDGEHOG ON STATE	85	1.51e-01	-9.01e-02	6.19e-01
REACTOME G1 S SPECIFIC TRANSCRIPTION	28	1.51e-01	-1.57e-01	6.19e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	188	1.51e-01	6.07e-02	6.19e-01
REACTOME REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	81	1.51e-01	-9.22e-02	6.19e-01
REACTOME PROTEIN FOLDING	96	1.52e-01	-8.45e-02	6.22e-01
REACTOME EXTRA NUCLEAR ESTROGEN SIGNALING	74	1.53e-01	-9.61e-02	6.24e-01
REACTOME SARS COV 1 INFECTION	136	1.54e-01	-7.08e-02	6.26e-01
REACTOME NEF MEDIATED CD8 DOWN REGULATION	7	1.55e-01	3.10e-01	6.28e-01
REACTOME TERMINAL PATHWAY OF COMPLEMENT	8	1.55e-01	2.90e-01	6.28e-01
REACTOME MYOCLONIC EPILEPSY OF LAFORA	9	1.56e-01	-2.73e-01	6.29e-01
REACTOME SARS COV 2 MODULATES HOST TRANSLATION MACHINERY	46	1.57e-01	-1.21e-01	6.30e-01
REACTOME TRANSCRIPTIONAL REGULATION BY E2F6	32	1.58e-01	-1.44e-01	6.32e-01
REACTOME SARS COV 2 HOST INTERACTIONS	191	1.58e-01	-5.93e-02	6.32e-01
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	29	1.58e-01	-1.51e-01	6.33e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	22	1.59e-01	1.73e-01	6.36e-01
REACTOME BUDDING AND MATURATION OF HIV VIRION	28	1.61e-01	-1.53e-01	6.37e-01
REACTOME SARS COV 1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS	16	1.61e-01	-2.03e-01	6.37e-01
REACTOME EARLY PHASE OF HIV LIFE CYCLE	14	1.61e-01	-2.16e-01	6.37e-01
REACTOME CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	19	1.61e-01	-1.86e-01	6.37e-01
REACTOME INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	37	1.63e-01	-1.33e-01	6.41e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	15	1.65e-01	2.07e-01	6.46e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	299	1.65e-01	-4.66e-02	6.48e-01
REACTOME INTRA GOLGI TRAFFIC	43	1.66e-01	-1.22e-01	6.49e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	14	1.67e-01	-2.13e-01	6.50e-01
REACTOME NUCLEOTIDE SALVAGE	21	1.68e-01	1.74e-01	6.52e-01
REACTOME CALCINEURIN ACTIVATES NFAT	9	1.68e-01	-2.65e-01	6.53e-01
REACTOME COPII MEDIATED VESICLE TRANSPORT	66	1.69e-01	-9.80e-02	6.53e-01
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	9	1.70e-01	2.64e-01	6.55e-01
REACTOME NEURONAL SYSTEM	388	1.70e-01	4.06e-02	6.55e-01
REACTOME NUCLEAR IMPORT OF REV PROTEIN	34	1.70e-01	-1.36e-01	6.55e-01
REACTOME LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	1.71e-01	-1.81e-01	6.56e-01
REACTOME AMYLOID FIBER FORMATION	102	1.72e-01	-7.83e-02	6.56e-01
REACTOME KERATAN SULFATE DEGRADATION	13	1.72e-01	-2.19e-01	6.56e-01
REACTOME SARS COV 2 MODULATES AUTOPHAGY	11	1.72e-01	-2.38e-01	6.57e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	15	1.73e-01	-2.03e-01	6.57e-01
REACTOME SUMOYLATION OF RNA BINDING PROTEINS	47	1.74e-01	-1.15e-01	6.60e-01
REACTOME RUNX2 REGULATES BONE DEVELOPMENT	29	1.75e-01	-1.46e-01	6.60e-01
REACTOME POLYMERASE SWITCHING	13	1.76e-01	-2.17e-01	6.65e-01
REACTOME SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	74	1.77e-01	-9.08e-02	6.65e-01
REACTOME TRNA PROCESSING IN THE NUCLEUS	58	1.78e-01	-1.02e-01	6.67e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	35	1.81e-01	-1.31e-01	6.77e-01
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	52	1.81e-01	-1.07e-01	6.77e-01
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES	30	1.82e-01	-1.41e-01	6.77e-01
REACTOME ER QUALITY CONTROL COMPARTMENT ERQC	21	1.82e-01	-1.68e-01	6.78e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	69	1.83e-01	9.28e-02	6.78e-01
REACTOME SIGNALING BY ERBB2	50	1.83e-01	-1.09e-01	6.78e-01
REACTOME PROTEIN REPAIR	6	1.83e-01	-3.14e-01	6.78e-01
REACTOME REGULATION OF NPAS4 GENE TRANSCRIPTION	5	1.86e-01	3.41e-01	6.86e-01
REACTOME REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	1.87e-01	-2.30e-01	6.86e-01
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	30	1.87e-01	1.39e-01	6.86e-01
REACTOME SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	16	1.88e-01	-1.90e-01	6.88e-01
REACTOME DNA REPLICATION INITIATION	7	1.89e-01	-2.87e-01	6.92e-01
REACTOME ER TO GOLGI ANTEROGRADE TRANSPORT	152	1.90e-01	-6.16e-02	6.92e-01
REACTOME TRYPTOPHAN CATABOLISM	14	1.90e-01	-2.02e-01	6.93e-01
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION	10	1.91e-01	-2.39e-01	6.93e-01
REACTOME METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	33	1.92e-01	-1.31e-01	6.93e-01
REACTOME INLA MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS	9	1.92e-01	-2.51e-01	6.93e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS	5	1.92e-01	-3.37e-01	6.94e-01
REACTOME NUCLEAR ENVELOPE BREAKDOWN	52	1.93e-01	-1.04e-01	6.96e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY DVL INTERACTING PROTEINS	5	1.94e-01	-3.35e-01	6.96e-01
REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	1.94e-01	1.72e-01	6.96e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	49	1.95e-01	-1.07e-01	6.99e-01
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS	5	1.96e-01	-3.34e-01	6.99e-01
REACTOME NICOTINATE METABOLISM	31	1.97e-01	-1.34e-01	7.00e-01
REACTOME DNA DAMAGE REVERSAL	8	1.97e-01	-2.63e-01	7.00e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	1.98e-01	-1.31e-01	7.02e-01
REACTOME ESTROGEN BIOSYNTHESIS	6	1.99e-01	3.03e-01	7.06e-01
REACTOME INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	103	2.01e-01	-7.30e-02	7.07e-01
REACTOME REGULATED NECROSIS	57	2.01e-01	-9.80e-02	7.07e-01
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	2.01e-01	1.91e-01	7.07e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	2.02e-01	2.04e-01	7.07e-01
REACTOME CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	77	2.02e-01	8.41e-02	7.07e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	27	2.03e-01	-1.41e-01	7.10e-01
REACTOME SIGNALING BY EGFR IN CANCER	25	2.04e-01	-1.47e-01	7.13e-01
REACTOME SULFUR AMINO ACID METABOLISM	27	2.06e-01	1.41e-01	7.15e-01
REACTOME RSK ACTIVATION	5	2.07e-01	-3.26e-01	7.16e-01
REACTOME G PROTEIN MEDIATED EVENTS	53	2.08e-01	1.00e-01	7.16e-01
REACTOME CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	24	2.08e-01	-1.49e-01	7.16e-01
REACTOME MEMBRANE TRAFFICKING	603	2.08e-01	-3.00e-02	7.16e-01
REACTOME CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	2.08e-01	-1.67e-01	7.16e-01
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	9	2.10e-01	-2.41e-01	7.20e-01
REACTOME GDP FUCOSE BIOSYNTHESIS	6	2.12e-01	-2.94e-01	7.21e-01
REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	24	2.13e-01	1.47e-01	7.21e-01
REACTOME PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING	5	2.13e-01	-3.22e-01	7.21e-01
REACTOME RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA	7	2.13e-01	-2.72e-01	7.21e-01
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	78	2.13e-01	-8.15e-02	7.21e-01
REACTOME G0 AND EARLY G1	27	2.13e-01	-1.38e-01	7.21e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	160	2.14e-01	-5.69e-02	7.21e-01
REACTOME NEGATIVE REGULATION OF FGFR4 SIGNALING	30	2.14e-01	1.31e-01	7.21e-01
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	14	2.15e-01	-1.92e-01	7.21e-01
REACTOME VLDL CLEARANCE	6	2.15e-01	2.92e-01	7.21e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	2.15e-01	-1.16e-01	7.21e-01
REACTOME SYNTHESIS OF GDP MANNOSE	5	2.15e-01	-3.20e-01	7.21e-01
REACTOME RUNX3 REGULATES WNT SIGNALING	8	2.16e-01	2.53e-01	7.21e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH CDC42	19	2.16e-01	-1.64e-01	7.22e-01
REACTOME VASOPRESSIN LIKE RECEPTORS	5	2.17e-01	3.19e-01	7.24e-01
REACTOME TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	76	2.18e-01	-8.18e-02	7.24e-01
REACTOME GLUCOSE METABOLISM	90	2.18e-01	-7.51e-02	7.24e-01
REACTOME DEFECTIVE CHST6 CAUSES MCDC1	8	2.19e-01	-2.51e-01	7.24e-01
REACTOME PROTON COUPLED MONOCARBOXYLATE TRANSPORT	6	2.21e-01	-2.89e-01	7.29e-01
REACTOME ARACHIDONIC ACID METABOLISM	57	2.21e-01	9.37e-02	7.29e-01
REACTOME EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	33	2.23e-01	-1.23e-01	7.32e-01
REACTOME SIGNALING BY CSF1 M CSF IN MYELOID CELLS	30	2.23e-01	-1.28e-01	7.32e-01
REACTOME NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	36	2.23e-01	1.17e-01	7.32e-01
REACTOME ROBO RECEPTORS BIND AKAP5	9	2.24e-01	-2.34e-01	7.32e-01
REACTOME DEFECTIVE B4GALT1 CAUSES B4GALT1 CDG CDG 2D	8	2.25e-01	-2.48e-01	7.34e-01
REACTOME AGGREPHAGY	42	2.26e-01	-1.08e-01	7.35e-01
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	39	2.27e-01	1.12e-01	7.39e-01
REACTOME CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	2.28e-01	-9.95e-02	7.40e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	98	2.29e-01	-7.02e-02	7.41e-01
REACTOME SUMO IS PROTEOLYTICALLY PROCESSED	6	2.30e-01	2.83e-01	7.41e-01
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	37	2.30e-01	-1.14e-01	7.41e-01
REACTOME RAS SIGNALING DOWNSTREAM OF NF1 LOSS OF FUNCTION VARIANTS	7	2.31e-01	-2.62e-01	7.43e-01
REACTOME INTERLEUKIN 27 SIGNALING	11	2.32e-01	2.08e-01	7.45e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	2.33e-01	-1.30e-01	7.48e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	46	2.34e-01	1.01e-01	7.48e-01
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	55	2.35e-01	-9.26e-02	7.49e-01
REACTOME RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	22	2.35e-01	-1.46e-01	7.49e-01
REACTOME ROLE OF ABL IN ROBO SLIT SIGNALING	8	2.37e-01	-2.41e-01	7.52e-01
REACTOME REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	11	2.37e-01	2.06e-01	7.52e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	14	2.38e-01	-1.82e-01	7.52e-01
REACTOME SIGNALING BY INSULIN RECEPTOR	80	2.39e-01	7.61e-02	7.52e-01
REACTOME SHC MEDIATED CASCADE FGFR4	19	2.39e-01	1.56e-01	7.52e-01
REACTOME GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	42	2.40e-01	-1.05e-01	7.52e-01
REACTOME FORMATION OF TC NER PRE INCISION COMPLEX	51	2.40e-01	-9.51e-02	7.52e-01
REACTOME CYTOPROTECTION BY HMOX1	59	2.40e-01	-8.84e-02	7.52e-01
REACTOME SYNTHESIS OF 12 EICOSATETRAENOIC ACID DERIVATIVES	7	2.41e-01	2.56e-01	7.52e-01
REACTOME SUMOYLATION OF DNA REPLICATION PROTEINS	46	2.41e-01	-9.99e-02	7.52e-01
REACTOME FGFR3B LIGAND BINDING AND ACTIVATION	7	2.41e-01	2.56e-01	7.52e-01
REACTOME FATTY ACIDS BOUND TO GPR40 FFAR1 REGULATE INSULIN SECRETION	8	2.42e-01	2.39e-01	7.52e-01
REACTOME VIRAL MESSENGER RNA SYNTHESIS	44	2.44e-01	-1.02e-01	7.52e-01
REACTOME ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	27	2.44e-01	1.30e-01	7.52e-01
REACTOME SUMOYLATION OF TRANSCRIPTION FACTORS	20	2.44e-01	-1.50e-01	7.52e-01
REACTOME RECYCLING OF BILE ACIDS AND SALTS	18	2.45e-01	1.58e-01	7.52e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES	33	2.45e-01	-1.17e-01	7.52e-01
REACTOME DUAL INCISION IN GG NER	39	2.45e-01	-1.08e-01	7.52e-01
REACTOME VESICLE MEDIATED TRANSPORT	642	2.46e-01	-2.69e-02	7.52e-01
REACTOME BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	2.46e-01	-1.40e-01	7.52e-01
REACTOME NEGATIVE REGULATION OF MAPK PATHWAY	41	2.46e-01	-1.05e-01	7.52e-01
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS	55	2.46e-01	9.04e-02	7.52e-01
REACTOME TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION	41	2.47e-01	-1.04e-01	7.52e-01
REACTOME DNA DAMAGE BYPASS	47	2.48e-01	-9.74e-02	7.52e-01
REACTOME HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS	7	2.48e-01	2.52e-01	7.52e-01
REACTOME HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND	55	2.48e-01	-9.01e-02	7.52e-01
REACTOME DEADENYLATION OF MRNA	25	2.48e-01	-1.33e-01	7.52e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	5	2.49e-01	2.98e-01	7.52e-01
REACTOME CHL1 INTERACTIONS	9	2.50e-01	-2.22e-01	7.52e-01
REACTOME MET ACTIVATES PTPN11	5	2.50e-01	2.97e-01	7.52e-01
REACTOME TRANSCRIPTIONAL REGULATION BY NPAS4	33	2.50e-01	1.16e-01	7.52e-01
REACTOME DISEASES OF MITOTIC CELL CYCLE	37	2.51e-01	-1.09e-01	7.53e-01
REACTOME COBALAMIN CBL METABOLISM	7	2.51e-01	-2.50e-01	7.53e-01
REACTOME G2 PHASE	5	2.54e-01	-2.95e-01	7.54e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	45	2.54e-01	9.83e-02	7.54e-01
REACTOME DARPP 32 EVENTS	24	2.55e-01	-1.34e-01	7.54e-01
REACTOME FCERI MEDIATED MAPK ACTIVATION	32	2.55e-01	-1.16e-01	7.54e-01
REACTOME FGFR1 MUTANT RECEPTOR ACTIVATION	31	2.55e-01	1.18e-01	7.54e-01
REACTOME DEFECTS IN COBALAMIN B12 METABOLISM	13	2.55e-01	-1.82e-01	7.54e-01
REACTOME CLEC7A INFLAMMASOME PATHWAY	6	2.56e-01	-2.68e-01	7.54e-01
REACTOME NUCLEAR PORE COMPLEX NPC DISASSEMBLY	36	2.57e-01	-1.09e-01	7.54e-01
REACTOME BILE ACID AND BILE SALT METABOLISM	45	2.57e-01	9.76e-02	7.54e-01
REACTOME RNA POLYMERASE III CHAIN ELONGATION	18	2.60e-01	-1.53e-01	7.54e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	19	2.60e-01	-1.49e-01	7.54e-01
REACTOME NEGATIVE REGULATION OF FGFR2 SIGNALING	33	2.60e-01	1.13e-01	7.54e-01
REACTOME RUNX3 REGULATES YAP1 MEDIATED TRANSCRIPTION	8	2.60e-01	2.30e-01	7.54e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	2.61e-01	-1.62e-01	7.54e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS	9	2.61e-01	-2.16e-01	7.54e-01
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	81	2.62e-01	-7.21e-02	7.54e-01
REACTOME INTERLEUKIN 6 FAMILY SIGNALING	24	2.62e-01	1.32e-01	7.54e-01
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	8	2.63e-01	-2.29e-01	7.54e-01
REACTOME GPER1 SIGNALING	45	2.63e-01	-9.65e-02	7.54e-01
REACTOME ESTROGEN STIMULATED SIGNALING THROUGH PRKCZ	6	2.64e-01	-2.64e-01	7.54e-01
REACTOME HS GAG BIOSYNTHESIS	28	2.64e-01	-1.22e-01	7.54e-01
REACTOME SIGNALING BY ALK IN CANCER	53	2.64e-01	-8.88e-02	7.54e-01
REACTOME CTLA4 INHIBITORY SIGNALING	21	2.66e-01	1.40e-01	7.54e-01
REACTOME SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	2.66e-01	-1.61e-01	7.54e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	20	2.66e-01	-1.44e-01	7.54e-01
REACTOME METABOLISM OF FAT SOLUBLE VITAMINS	46	2.67e-01	9.46e-02	7.54e-01
REACTOME COLLAGEN DEGRADATION	61	2.67e-01	-8.21e-02	7.54e-01
REACTOME DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS	14	2.67e-01	1.71e-01	7.54e-01
REACTOME SIGNAL TRANSDUCTION BY L1	20	2.67e-01	-1.43e-01	7.54e-01
REACTOME DAG AND IP3 SIGNALING	40	2.67e-01	1.01e-01	7.54e-01
REACTOME INSULIN RECEPTOR RECYCLING	29	2.68e-01	1.19e-01	7.54e-01
REACTOME RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	16	2.68e-01	-1.60e-01	7.54e-01
REACTOME G ALPHA 12 13 SIGNALLING EVENTS	74	2.69e-01	7.43e-02	7.54e-01
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	19	2.69e-01	-1.46e-01	7.54e-01
REACTOME NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY	6	2.69e-01	-2.60e-01	7.54e-01
REACTOME CHROMATIN MODIFYING ENZYMES	252	2.70e-01	-4.04e-02	7.54e-01
REACTOME CALCITONIN LIKE LIGAND RECEPTORS	10	2.70e-01	2.02e-01	7.54e-01
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	26	2.70e-01	1.25e-01	7.54e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	62	2.70e-01	8.10e-02	7.54e-01
REACTOME INTEGRIN SIGNALING	27	2.70e-01	1.23e-01	7.54e-01
REACTOME LYSOSOME VESICLE BIOGENESIS	33	2.71e-01	1.11e-01	7.54e-01
REACTOME DEFECTIVE CHST14 CAUSES EDS MUSCULOCONTRACTURAL TYPE	7	2.71e-01	2.40e-01	7.54e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	89	2.72e-01	-6.74e-02	7.54e-01
REACTOME DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	15	2.72e-01	1.64e-01	7.54e-01
REACTOME PARACETAMOL ADME	26	2.72e-01	-1.24e-01	7.54e-01
REACTOME ZINC TRANSPORTERS	15	2.73e-01	-1.64e-01	7.54e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	16	2.75e-01	-1.58e-01	7.58e-01
REACTOME GAP JUNCTION ASSEMBLY	36	2.77e-01	1.05e-01	7.59e-01
REACTOME METABOLISM OF COFACTORS	19	2.77e-01	-1.44e-01	7.59e-01
REACTOME TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE	10	2.77e-01	1.99e-01	7.59e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	2.77e-01	-8.04e-02	7.60e-01
REACTOME SIGNALING BY ERBB2 ECD MUTANTS	16	2.79e-01	-1.56e-01	7.61e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	32	2.79e-01	-1.11e-01	7.61e-01
REACTOME PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	2.79e-01	1.88e-01	7.61e-01
REACTOME RELAXIN RECEPTORS	8	2.81e-01	2.20e-01	7.65e-01
REACTOME LATE ENDOSOMAL MICROAUTOPHAGY	33	2.81e-01	-1.08e-01	7.65e-01
REACTOME SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	14	2.82e-01	-1.66e-01	7.65e-01
REACTOME TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	2.85e-01	-1.08e-01	7.71e-01
REACTOME CATION COUPLED CHLORIDE COTRANSPORTERS	7	2.85e-01	2.33e-01	7.71e-01
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	418	2.86e-01	-3.04e-02	7.71e-01
REACTOME TYSND1 CLEAVES PEROXISOMAL PROTEINS	7	2.86e-01	-2.33e-01	7.71e-01
REACTOME DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	2.87e-01	-1.34e-01	7.71e-01
REACTOME POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	27	2.89e-01	-1.18e-01	7.71e-01
REACTOME SIGNALING BY NTRKS	132	2.89e-01	-5.35e-02	7.71e-01
REACTOME FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	2.89e-01	1.94e-01	7.71e-01
REACTOME SIGNALING BY VEGF	102	2.89e-01	-6.08e-02	7.71e-01
REACTOME SMOOTH MUSCLE CONTRACTION	43	2.89e-01	9.34e-02	7.71e-01
REACTOME INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA	11	2.89e-01	-1.85e-01	7.71e-01
REACTOME EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	2.90e-01	1.18e-01	7.71e-01
REACTOME NFE2L2 REGULATING ANTI OXIDANT DETOXIFICATION ENZYMES	17	2.90e-01	1.48e-01	7.71e-01
REACTOME PTEN REGULATION	135	2.92e-01	-5.26e-02	7.74e-01
REACTOME CONSTITUTIVE SIGNALING BY EGFRVIII	15	2.92e-01	-1.57e-01	7.74e-01
REACTOME TYROSINE CATABOLISM	5	2.93e-01	-2.72e-01	7.74e-01
REACTOME SARS COV 2 INFECTION	281	2.93e-01	-3.64e-02	7.74e-01
REACTOME 2 LTR CIRCLE FORMATION	7	2.94e-01	-2.29e-01	7.75e-01
REACTOME SIGNALING BY EGFR	49	2.95e-01	-8.64e-02	7.75e-01
REACTOME MULTIFUNCTIONAL ANION EXCHANGERS	9	2.95e-01	2.01e-01	7.75e-01
REACTOME HIV TRANSCRIPTION INITIATION	43	2.96e-01	-9.22e-02	7.75e-01
REACTOME SUMOYLATION OF DNA METHYLATION PROTEINS	16	2.96e-01	-1.51e-01	7.76e-01
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE	5	3.00e-01	2.68e-01	7.82e-01
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	23	3.00e-01	1.25e-01	7.82e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS	6	3.00e-01	2.44e-01	7.82e-01
REACTOME REGULATION OF NPAS4 GENE EXPRESSION	13	3.01e-01	1.66e-01	7.83e-01
REACTOME MAPK FAMILY SIGNALING CASCADES	314	3.02e-01	-3.39e-02	7.83e-01
REACTOME PERK REGULATES GENE EXPRESSION	31	3.02e-01	1.07e-01	7.83e-01
REACTOME RIBAVIRIN ADME	11	3.03e-01	-1.79e-01	7.84e-01
REACTOME INTERLEUKIN 9 SIGNALING	7	3.03e-01	2.25e-01	7.84e-01
REACTOME GLYCOGEN STORAGE DISEASES	15	3.05e-01	-1.53e-01	7.87e-01
REACTOME TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	29	3.06e-01	-1.10e-01	7.87e-01
REACTOME HDL CLEARANCE	5	3.07e-01	2.64e-01	7.87e-01
REACTOME METAL ION SLC TRANSPORTERS	23	3.07e-01	-1.23e-01	7.87e-01
REACTOME PYRUVATE METABOLISM	29	3.07e-01	-1.10e-01	7.87e-01
REACTOME ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	74	3.08e-01	-6.86e-02	7.87e-01
REACTOME DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	77	3.08e-01	-6.72e-02	7.87e-01
REACTOME CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	13	3.09e-01	-1.63e-01	7.88e-01
REACTOME THE NLRP3 INFLAMMASOME	16	3.10e-01	-1.47e-01	7.88e-01
REACTOME REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	3.10e-01	1.07e-01	7.88e-01
REACTOME NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	20	3.11e-01	1.31e-01	7.88e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	24	3.13e-01	-1.19e-01	7.88e-01
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	291	3.13e-01	3.44e-02	7.88e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	3.13e-01	-1.22e-01	7.88e-01
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	3.13e-01	1.62e-01	7.88e-01
REACTOME COMPLEMENT CASCADE	54	3.13e-01	7.93e-02	7.88e-01
REACTOME UBIQUINOL BIOSYNTHESIS	8	3.13e-01	-2.06e-01	7.88e-01
REACTOME MODULATION BY MTB OF HOST IMMUNE SYSTEM	6	3.14e-01	-2.37e-01	7.88e-01
REACTOME ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	42	3.14e-01	-8.98e-02	7.88e-01
REACTOME WNT LIGAND BIOGENESIS AND TRAFFICKING	25	3.15e-01	1.16e-01	7.88e-01
REACTOME SUMOYLATION OF UBIQUITINYLATION PROTEINS	39	3.15e-01	-9.29e-02	7.89e-01
REACTOME INTERLEUKIN 15 SIGNALING	13	3.16e-01	1.61e-01	7.89e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	30	3.16e-01	-1.06e-01	7.89e-01
REACTOME VITAMIN B1 THIAMIN METABOLISM	5	3.17e-01	2.58e-01	7.91e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	20	3.18e-01	1.29e-01	7.92e-01
REACTOME SCAVENGING BY CLASS B RECEPTORS	6	3.19e-01	2.35e-01	7.92e-01
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	3.19e-01	1.48e-01	7.92e-01
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	13	3.21e-01	-1.59e-01	7.94e-01
REACTOME SULFIDE OXIDATION TO SULFATE	6	3.21e-01	2.34e-01	7.94e-01
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	66	3.22e-01	7.05e-02	7.94e-01
REACTOME SARS COV 1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES	39	3.23e-01	-9.15e-02	7.94e-01
REACTOME SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	52	3.25e-01	7.90e-02	7.94e-01
REACTOME BETA OXIDATION OF LAUROYL COA TO DECANOYL COA COA	5	3.25e-01	-2.54e-01	7.94e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	250	3.25e-01	3.61e-02	7.94e-01
REACTOME UNWINDING OF DNA	12	3.26e-01	-1.64e-01	7.94e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	16	3.26e-01	1.42e-01	7.94e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES	51	3.26e-01	7.95e-02	7.94e-01
REACTOME DNA STRAND ELONGATION	31	3.28e-01	-1.01e-01	7.94e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE	5	3.29e-01	-2.52e-01	7.94e-01
REACTOME RECYCLING PATHWAY OF L1	43	3.29e-01	8.60e-02	7.94e-01
REACTOME SYNTHESIS OF DIPHTHAMIDE EEF2	8	3.29e-01	-1.99e-01	7.94e-01
REACTOME RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	3.30e-01	-1.05e-01	7.94e-01
REACTOME DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	17	3.30e-01	1.37e-01	7.94e-01
REACTOME FGFR2 MUTANT RECEPTOR ACTIVATION	32	3.30e-01	9.95e-02	7.94e-01
REACTOME CELL CELL JUNCTION ORGANIZATION	64	3.31e-01	7.03e-02	7.94e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	11	3.32e-01	-1.69e-01	7.94e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	40	3.32e-01	-8.86e-02	7.94e-01
REACTOME GLUTATHIONE CONJUGATION	33	3.32e-01	9.76e-02	7.94e-01
REACTOME ALK MUTANTS BIND TKIS	12	3.32e-01	-1.62e-01	7.94e-01
REACTOME EPITHELIAL MESENCHYMAL TRANSITION EMT DURING GASTRULATION	7	3.33e-01	-2.11e-01	7.94e-01
REACTOME GAP JUNCTION TRAFFICKING AND REGULATION	49	3.34e-01	7.98e-02	7.94e-01
REACTOME ACTIVATION OF CASPASES THROUGH APOPTOSOME MEDIATED CLEAVAGE	5	3.34e-01	-2.49e-01	7.94e-01
REACTOME ERYTHROPOIETIN ACTIVATES RAS	14	3.34e-01	-1.49e-01	7.94e-01
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	10	3.34e-01	-1.76e-01	7.94e-01
REACTOME RAB GERANYLGERANYLATION	57	3.35e-01	-7.38e-02	7.94e-01
REACTOME INFLAMMASOMES	21	3.35e-01	-1.21e-01	7.94e-01
REACTOME ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	18	3.36e-01	1.31e-01	7.94e-01
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH RAS	8	3.37e-01	-1.96e-01	7.94e-01
REACTOME SIGNAL ATTENUATION	10	3.37e-01	1.75e-01	7.94e-01
REACTOME DISINHIBITION OF SNARE FORMATION	5	3.37e-01	-2.48e-01	7.94e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	23	3.37e-01	1.16e-01	7.94e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	53	3.37e-01	7.62e-02	7.94e-01
REACTOME TNFR1 MEDIATED CERAMIDE PRODUCTION	6	3.38e-01	-2.26e-01	7.94e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	32	3.40e-01	-9.75e-02	7.95e-01
REACTOME UREA CYCLE	9	3.41e-01	1.83e-01	7.95e-01
REACTOME CARNITINE METABOLISM	13	3.41e-01	-1.53e-01	7.95e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	3.41e-01	-7.56e-02	7.95e-01
REACTOME METABOLISM OF STEROID HORMONES	35	3.41e-01	-9.30e-02	7.95e-01
REACTOME ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	41	3.43e-01	-8.56e-02	7.95e-01
REACTOME NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	3.43e-01	-9.39e-02	7.95e-01
REACTOME UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	3.44e-01	-1.03e-01	7.95e-01
REACTOME THE ACTIVATION OF ARYLSULFATASES	8	3.45e-01	1.93e-01	7.95e-01
REACTOME RUNX3 REGULATES BCL2L11 BIM TRANSCRIPTION	5	3.45e-01	2.44e-01	7.95e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	91	3.45e-01	5.73e-02	7.95e-01
REACTOME DEATH RECEPTOR SIGNALING	143	3.45e-01	4.57e-02	7.95e-01
REACTOME NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	3.46e-01	1.57e-01	7.95e-01
REACTOME C TYPE LECTIN RECEPTORS CLRS	136	3.46e-01	-4.68e-02	7.95e-01
REACTOME TELOMERE C STRAND SYNTHESIS INITIATION	12	3.47e-01	-1.57e-01	7.95e-01
REACTOME ACTIVATION OF RAC1	12	3.47e-01	-1.57e-01	7.95e-01
REACTOME SIGNALING BY NTRK3 TRKC	17	3.47e-01	-1.32e-01	7.95e-01
REACTOME ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	41	3.47e-01	8.48e-02	7.95e-01
REACTOME DUAL INCISION IN TC NER	63	3.47e-01	-6.85e-02	7.95e-01
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	18	3.48e-01	1.28e-01	7.95e-01
REACTOME TRIGLYCERIDE CATABOLISM	23	3.48e-01	1.13e-01	7.95e-01
REACTOME NEUREXINS AND NEUROLIGINS	51	3.49e-01	7.58e-02	7.95e-01
REACTOME FORMATION OF AXIAL MESODERM	14	3.49e-01	-1.44e-01	7.95e-01
REACTOME GLUCOCORTICOID BIOSYNTHESIS	10	3.49e-01	-1.71e-01	7.95e-01
REACTOME SYNTHESIS OF PE	13	3.50e-01	-1.50e-01	7.96e-01
REACTOME CALNEXIN CALRETICULIN CYCLE	26	3.51e-01	-1.06e-01	7.96e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS	14	3.51e-01	-1.44e-01	7.96e-01
REACTOME APEX1 INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	7	3.52e-01	2.03e-01	7.96e-01
REACTOME SUMOYLATION OF SUMOYLATION PROTEINS	35	3.52e-01	-9.08e-02	7.96e-01
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	296	3.53e-01	-3.14e-02	7.96e-01
REACTOME RHOJ GTPASE CYCLE	51	3.54e-01	-7.51e-02	7.97e-01
REACTOME STAT5 ACTIVATION	7	3.55e-01	2.02e-01	7.97e-01
REACTOME NEGATIVE REGULATION OF FGFR3 SIGNALING	28	3.56e-01	1.01e-01	7.97e-01
REACTOME MITOCHONDRIAL CALCIUM ION TRANSPORT	23	3.56e-01	1.11e-01	7.97e-01
REACTOME INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	14	3.56e-01	-1.43e-01	7.97e-01
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	19	3.56e-01	-1.22e-01	7.97e-01
REACTOME REGULATION OF BETA CELL DEVELOPMENT	41	3.58e-01	-8.30e-02	7.98e-01
REACTOME FORMATION OF LATERAL PLATE MESODERM	5	3.58e-01	-2.38e-01	7.98e-01
REACTOME N GLYCAN TRIMMING AND ELONGATION IN THE CIS GOLGI	5	3.59e-01	2.37e-01	8.00e-01
REACTOME NEUTROPHIL DEGRANULATION	460	3.60e-01	2.49e-02	8.01e-01
REACTOME FGFRL1 MODULATION OF FGFR1 SIGNALING	13	3.61e-01	1.46e-01	8.01e-01
REACTOME PECAM1 INTERACTIONS	12	3.63e-01	1.52e-01	8.05e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	17	3.64e-01	-1.27e-01	8.05e-01
REACTOME EARLY SARS COV 2 INFECTION EVENTS	34	3.65e-01	-8.98e-02	8.05e-01
REACTOME PROSTANOID LIGAND RECEPTORS	9	3.65e-01	1.74e-01	8.05e-01
REACTOME FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS	8	3.65e-01	1.85e-01	8.05e-01
REACTOME ROS AND RNS PRODUCTION IN PHAGOCYTES	34	3.66e-01	8.95e-02	8.06e-01
REACTOME LONG TERM POTENTIATION	22	3.66e-01	1.11e-01	8.06e-01
REACTOME PLASMA LIPOPROTEIN CLEARANCE	37	3.67e-01	8.57e-02	8.06e-01
REACTOME RAC1 GTPASE CYCLE	172	3.68e-01	-3.98e-02	8.07e-01
REACTOME UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	19	3.69e-01	1.19e-01	8.07e-01
REACTOME APOPTOTIC FACTOR MEDIATED RESPONSE	19	3.69e-01	-1.19e-01	8.07e-01
REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	111	3.69e-01	4.93e-02	8.07e-01
REACTOME FRS MEDIATED FGFR4 SIGNALING	21	3.70e-01	1.13e-01	8.08e-01
REACTOME RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION	6	3.73e-01	2.10e-01	8.12e-01
REACTOME COPI MEDIATED ANTEROGRADE TRANSPORT	101	3.74e-01	-5.12e-02	8.13e-01
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE	9	3.74e-01	-1.71e-01	8.13e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	3.75e-01	-1.01e-01	8.14e-01
REACTOME RNA POLYMERASE II TRANSCRIPTION TERMINATION	62	3.75e-01	-6.51e-02	8.14e-01
REACTOME ENDOSOMAL VACUOLAR PATHWAY	11	3.77e-01	1.54e-01	8.16e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS	12	3.78e-01	1.47e-01	8.16e-01
REACTOME TRANSLESION SYNTHESIS BY POLH	19	3.78e-01	-1.17e-01	8.16e-01
REACTOME DOWNREGULATION OF ERBB4 SIGNALING	9	3.79e-01	-1.69e-01	8.16e-01
REACTOME NEGATIVE REGULATION OF FGFR1 SIGNALING	32	3.79e-01	8.99e-02	8.16e-01
REACTOME SIGNALING BY KIT IN DISEASE	20	3.80e-01	1.13e-01	8.16e-01
REACTOME CHAPERONE MEDIATED AUTOPHAGY	20	3.80e-01	-1.13e-01	8.16e-01
REACTOME CD22 MEDIATED BCR REGULATION	5	3.85e-01	2.25e-01	8.22e-01
REACTOME BH3 ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI APOPTOTIC BCL 2 MEMBERS	9	3.85e-01	1.67e-01	8.22e-01
REACTOME MATURATION OF SARS COV 2 NUCLEOPROTEIN	15	3.86e-01	-1.29e-01	8.22e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	19	3.86e-01	-1.15e-01	8.22e-01
REACTOME EGFR TRANSACTIVATION BY GASTRIN	9	3.86e-01	-1.67e-01	8.22e-01
REACTOME RNA POLYMERASE II TRANSCRIBES SNRNA GENES	77	3.86e-01	-5.71e-02	8.22e-01
REACTOME RHOF GTPASE CYCLE	40	3.86e-01	7.92e-02	8.22e-01
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	18	3.87e-01	1.18e-01	8.23e-01
REACTOME CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	16	3.88e-01	1.25e-01	8.23e-01
REACTOME DIGESTION AND ABSORPTION	22	3.89e-01	1.06e-01	8.23e-01
REACTOME RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION	6	3.89e-01	-2.03e-01	8.23e-01
REACTOME ADRENOCEPTORS	9	3.90e-01	1.66e-01	8.23e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS	28	3.90e-01	-9.39e-02	8.23e-01
REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES	507	3.90e-01	-2.23e-02	8.23e-01
REACTOME COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	38	3.91e-01	-8.05e-02	8.23e-01
REACTOME CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	25	3.93e-01	9.87e-02	8.27e-01
REACTOME HDR THROUGH MMEJ ALT NHEJ	12	3.94e-01	-1.42e-01	8.28e-01
REACTOME CELLULAR RESPONSE TO HEAT STRESS	99	3.95e-01	-4.95e-02	8.28e-01
REACTOME COHESIN LOADING ONTO CHROMATIN	8	3.95e-01	-1.74e-01	8.28e-01
REACTOME BETA CATENIN PHOSPHORYLATION CASCADE	16	3.95e-01	-1.23e-01	8.28e-01
REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV 1 INFECTION	5	3.96e-01	-2.19e-01	8.28e-01
REACTOME RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION	8	3.96e-01	1.73e-01	8.28e-01
REACTOME BIOTIN TRANSPORT AND METABOLISM	10	3.98e-01	-1.54e-01	8.29e-01
REACTOME REGULATION OF KIT SIGNALING	16	3.98e-01	1.22e-01	8.29e-01
REACTOME SARS COV INFECTIONS	392	3.99e-01	-2.48e-02	8.29e-01
REACTOME REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	53	4.00e-01	-6.68e-02	8.29e-01
REACTOME BASIGIN INTERACTIONS	24	4.01e-01	-9.91e-02	8.29e-01
REACTOME SIGNALING BY HIPPO	19	4.01e-01	-1.11e-01	8.29e-01
REACTOME OPIOID SIGNALLING	89	4.01e-01	5.15e-02	8.29e-01
REACTOME IRE1ALPHA ACTIVATES CHAPERONES	48	4.01e-01	-7.01e-02	8.29e-01
REACTOME NPAS4 REGULATES EXPRESSION OF TARGET GENES	21	4.02e-01	1.06e-01	8.29e-01
REACTOME TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	82	4.02e-01	-5.35e-02	8.29e-01
REACTOME INTERLEUKIN 2 FAMILY SIGNALING	40	4.03e-01	7.65e-02	8.29e-01
REACTOME EPH EPHRIN SIGNALING	90	4.03e-01	5.10e-02	8.29e-01
REACTOME LDL CLEARANCE	19	4.04e-01	1.11e-01	8.29e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	37	4.04e-01	-7.93e-02	8.29e-01
REACTOME REGULATION OF INSULIN SECRETION	77	4.05e-01	5.49e-02	8.30e-01
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	361	4.06e-01	-2.55e-02	8.31e-01
REACTOME NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	4.07e-01	1.51e-01	8.32e-01
REACTOME MATURATION OF SARS COV 2 SPIKE PROTEIN	35	4.08e-01	8.08e-02	8.32e-01
REACTOME METABOLISM OF INGESTED SEMET SEC MESEC INTO H2SE	7	4.08e-01	1.81e-01	8.32e-01
REACTOME GOLGI TO ER RETROGRADE TRANSPORT	132	4.09e-01	-4.16e-02	8.32e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE	35	4.09e-01	8.07e-02	8.32e-01
REACTOME SIGNALING BY ERYTHROPOIETIN	25	4.12e-01	-9.48e-02	8.38e-01
REACTOME DISEASES OF CARBOHYDRATE METABOLISM	31	4.13e-01	-8.50e-02	8.38e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	255	4.13e-01	2.98e-02	8.38e-01
REACTOME DEFECTIVE CSF2RB CAUSES SMDP5	7	4.14e-01	1.78e-01	8.39e-01
REACTOME BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	42	4.16e-01	7.25e-02	8.41e-01
REACTOME SIGNALING BY ACTIVIN	15	4.17e-01	-1.21e-01	8.41e-01
REACTOME GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	30	4.18e-01	8.55e-02	8.42e-01
REACTOME ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA	9	4.18e-01	-1.56e-01	8.42e-01
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	134	4.21e-01	-4.03e-02	8.46e-01
REACTOME RUNX3 REGULATES P14 ARF	10	4.23e-01	-1.46e-01	8.49e-01
REACTOME HDL ASSEMBLY	8	4.24e-01	-1.63e-01	8.49e-01
REACTOME CD28 CO STIMULATION	32	4.25e-01	8.16e-02	8.49e-01
REACTOME ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS	7	4.25e-01	1.74e-01	8.49e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	4.26e-01	1.39e-01	8.49e-01
REACTOME TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	71	4.26e-01	-5.47e-02	8.49e-01
REACTOME SELECTIVE AUTOPHAGY	79	4.26e-01	-5.18e-02	8.49e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	50	4.27e-01	-6.49e-02	8.49e-01
REACTOME NEF MEDIATED CD4 DOWN REGULATION	9	4.28e-01	1.53e-01	8.49e-01
REACTOME DEFECTIVE CHST3 CAUSES SEDCJD	7	4.28e-01	1.73e-01	8.49e-01
REACTOME VEGFR2 MEDIATED CELL PROLIFERATION	19	4.28e-01	-1.05e-01	8.49e-01
REACTOME PIWI INTERACTING RNA PIRNA BIOGENESIS	29	4.29e-01	8.49e-02	8.49e-01
REACTOME GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	14	4.29e-01	-1.22e-01	8.49e-01
REACTOME HEMOSTASIS	591	4.30e-01	-1.90e-02	8.49e-01
REACTOME RNA POLYMERASE II PRE TRANSCRIPTION EVENTS	77	4.30e-01	-5.20e-02	8.49e-01
REACTOME DOWNREGULATION OF ERBB2 SIGNALING	29	4.31e-01	-8.45e-02	8.49e-01
REACTOME SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	4.31e-01	9.10e-02	8.49e-01
REACTOME DAP12 SIGNALING	27	4.31e-01	-8.75e-02	8.49e-01
REACTOME VXPX CARGO TARGETING TO CILIUM	20	4.32e-01	-1.02e-01	8.49e-01
REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	22	4.32e-01	9.67e-02	8.49e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	35	4.34e-01	-7.65e-02	8.49e-01
REACTOME CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	25	4.34e-01	9.05e-02	8.49e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM	34	4.34e-01	-7.76e-02	8.49e-01
REACTOME BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	10	4.35e-01	-1.43e-01	8.49e-01
REACTOME AFLATOXIN ACTIVATION AND DETOXIFICATION	19	4.35e-01	1.03e-01	8.49e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING	5	4.36e-01	-2.01e-01	8.49e-01
REACTOME PRE NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM	6	4.36e-01	-1.84e-01	8.49e-01
REACTOME SHC MEDIATED CASCADE FGFR3	17	4.36e-01	1.09e-01	8.49e-01
REACTOME METABOLISM OF CARBOHYDRATES	279	4.37e-01	-2.70e-02	8.49e-01
REACTOME FGFR1B LIGAND BINDING AND ACTIVATION	6	4.39e-01	1.83e-01	8.51e-01
REACTOME MATURATION OF PROTEIN 3A	9	4.39e-01	1.49e-01	8.51e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION	41	4.39e-01	-6.98e-02	8.51e-01
REACTOME IRS MEDIATED SIGNALLING	47	4.41e-01	6.50e-02	8.51e-01
REACTOME FRS MEDIATED FGFR2 SIGNALING	24	4.41e-01	9.08e-02	8.51e-01
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	63	4.42e-01	5.61e-02	8.51e-01
REACTOME COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	21	4.42e-01	-9.69e-02	8.51e-01
REACTOME ION HOMEOSTASIS	52	4.42e-01	6.16e-02	8.51e-01
REACTOME INWARDLY RECTIFYING K CHANNELS	35	4.42e-01	-7.50e-02	8.51e-01
REACTOME ASSEMBLY OF THE HIV VIRION	16	4.43e-01	-1.11e-01	8.51e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	28	4.44e-01	8.37e-02	8.51e-01
REACTOME SIGNALLING TO ERKS	34	4.45e-01	-7.58e-02	8.51e-01
REACTOME PHENYLALANINE AND TYROSINE METABOLISM	11	4.45e-01	-1.33e-01	8.51e-01
REACTOME TIE2 SIGNALING	18	4.46e-01	-1.04e-01	8.52e-01
REACTOME SELENOAMINO ACID METABOLISM	108	4.46e-01	-4.24e-02	8.52e-01
REACTOME SIGNALING BY NOTCH3	48	4.47e-01	6.34e-02	8.52e-01
REACTOME MET PROMOTES CELL MOTILITY	41	4.48e-01	6.84e-02	8.54e-01
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	14	4.49e-01	1.17e-01	8.54e-01
REACTOME L1CAM INTERACTIONS	112	4.49e-01	4.14e-02	8.54e-01
REACTOME CELL CELL COMMUNICATION	126	4.50e-01	3.89e-02	8.55e-01
REACTOME FORMATION OF PARAXIAL MESODERM	22	4.51e-01	9.29e-02	8.55e-01
REACTOME TRANSCRIPTION OF THE HIV GENOME	66	4.52e-01	-5.36e-02	8.55e-01
REACTOME MET ACTIVATES PI3K AKT SIGNALING	6	4.52e-01	1.77e-01	8.55e-01
REACTOME TRNA MODIFICATION IN THE MITOCHONDRION	8	4.53e-01	-1.53e-01	8.55e-01
REACTOME RHOBTB GTPASE CYCLE	34	4.53e-01	-7.43e-02	8.55e-01
REACTOME SIGNALING BY FGFR1 IN DISEASE	38	4.54e-01	7.02e-02	8.56e-01
REACTOME LATE SARS COV 2 INFECTION EVENTS	67	4.56e-01	5.27e-02	8.56e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	51	4.56e-01	-6.03e-02	8.56e-01
REACTOME TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	10	4.56e-01	-1.36e-01	8.56e-01
REACTOME TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	36	4.56e-01	-7.17e-02	8.56e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	83	4.58e-01	4.71e-02	8.59e-01
REACTOME FLT3 SIGNALING	38	4.59e-01	-6.94e-02	8.60e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	4.61e-01	-7.20e-02	8.60e-01
REACTOME GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	4.61e-01	-8.52e-02	8.60e-01
REACTOME ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	28	4.61e-01	8.04e-02	8.60e-01
REACTOME CITRIC ACID CYCLE TCA CYCLE	21	4.62e-01	-9.27e-02	8.60e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	4.62e-01	1.14e-01	8.60e-01
REACTOME RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS	9	4.63e-01	1.41e-01	8.60e-01
REACTOME PROCESSING OF SMDT1	16	4.64e-01	1.06e-01	8.60e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH RAS	9	4.64e-01	-1.41e-01	8.60e-01
REACTOME BLOOD GROUP SYSTEMS BIOSYNTHESIS	21	4.65e-01	-9.20e-02	8.61e-01
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH PI3K	6	4.66e-01	-1.72e-01	8.61e-01
REACTOME SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	4.66e-01	-1.17e-01	8.61e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	4.66e-01	8.26e-02	8.61e-01
REACTOME SIGNALING BY PDGFR IN DISEASE	20	4.69e-01	-9.36e-02	8.62e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	31	4.69e-01	-7.52e-02	8.62e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	12	4.69e-01	-1.21e-01	8.62e-01
REACTOME FGFR2 ALTERNATIVE SPLICING	27	4.69e-01	-8.04e-02	8.62e-01
REACTOME LTC4 CYSLTR MEDIATED IL4 PRODUCTION	6	4.70e-01	1.70e-01	8.62e-01
REACTOME PLATELET HOMEOSTASIS	85	4.70e-01	4.53e-02	8.62e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH CDK5	6	4.70e-01	1.70e-01	8.62e-01
REACTOME METABOLISM OF AMINE DERIVED HORMONES	17	4.71e-01	1.01e-01	8.62e-01
REACTOME SIGNALING BY TGFB FAMILY MEMBERS	119	4.72e-01	-3.82e-02	8.62e-01
REACTOME SHC MEDIATED CASCADE FGFR1	21	4.72e-01	9.07e-02	8.62e-01
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	11	4.74e-01	1.25e-01	8.64e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS	7	4.75e-01	-1.56e-01	8.64e-01
REACTOME PEXOPHAGY	11	4.75e-01	-1.24e-01	8.64e-01
REACTOME PHASE 3 RAPID REPOLARISATION	8	4.75e-01	1.46e-01	8.64e-01
REACTOME PROTEIN LOCALIZATION	153	4.76e-01	-3.34e-02	8.65e-01
REACTOME SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	4.77e-01	-1.19e-01	8.65e-01
REACTOME SYNTHESIS OF UDP N ACETYL GLUCOSAMINE	7	4.79e-01	1.55e-01	8.68e-01
REACTOME ASPARTATE AND ASPARAGINE METABOLISM	11	4.81e-01	1.23e-01	8.69e-01
REACTOME FCGR ACTIVATION	11	4.81e-01	-1.23e-01	8.69e-01
REACTOME O LINKED GLYCOSYLATION	109	4.82e-01	3.90e-02	8.69e-01
REACTOME TRANSCRIPTIONAL REGULATION BY MECP2	60	4.82e-01	5.24e-02	8.69e-01
REACTOME RHO GTPASE CYCLE	423	4.83e-01	-1.99e-02	8.69e-01
REACTOME FLT3 SIGNALING THROUGH SRC FAMILY KINASES	6	4.83e-01	1.65e-01	8.69e-01
REACTOME CRISTAE FORMATION	27	4.86e-01	7.75e-02	8.71e-01
REACTOME ORGANIC ANION TRANSPORT	5	4.86e-01	1.80e-01	8.71e-01
REACTOME BIOSYNTHESIS OF EPA DERIVED SPMS	6	4.86e-01	-1.64e-01	8.71e-01
REACTOME TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	39	4.86e-01	-6.45e-02	8.71e-01
REACTOME CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	45	4.87e-01	5.99e-02	8.72e-01
REACTOME OVARIAN TUMOR DOMAIN PROTEASES	36	4.88e-01	-6.67e-02	8.73e-01
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION	59	4.88e-01	5.21e-02	8.73e-01
REACTOME POLB DEPENDENT LONG PATCH BASE EXCISION REPAIR	8	4.90e-01	-1.41e-01	8.75e-01
REACTOME REGULATION OF TP53 ACTIVITY	156	4.93e-01	-3.18e-02	8.77e-01
REACTOME HYALURONAN UPTAKE AND DEGRADATION	12	4.93e-01	-1.14e-01	8.77e-01
REACTOME TACHYKININ RECEPTORS BIND TACHYKININS	5	4.93e-01	-1.77e-01	8.77e-01
REACTOME SHC RELATED EVENTS TRIGGERED BY IGF1R	9	4.94e-01	-1.32e-01	8.77e-01
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	11	4.95e-01	1.19e-01	8.78e-01
REACTOME REACTIONS SPECIFIC TO THE COMPLEX N GLYCAN SYNTHESIS PATHWAY	10	4.96e-01	1.24e-01	8.79e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	4.96e-01	-7.43e-02	8.79e-01
REACTOME RHO GTPASES ACTIVATE KTN1	11	4.98e-01	1.18e-01	8.80e-01
REACTOME SYNTHESIS OF LIPOXINS LX	6	4.98e-01	1.60e-01	8.81e-01
REACTOME TP53 REGULATES METABOLIC GENES	81	4.99e-01	-4.34e-02	8.81e-01
REACTOME VITAMIN C ASCORBATE METABOLISM	8	4.99e-01	1.38e-01	8.81e-01
REACTOME INTERLEUKIN 20 FAMILY SIGNALING	25	5.01e-01	7.78e-02	8.82e-01
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	15	5.01e-01	-1.00e-01	8.82e-01
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	5.03e-01	-6.96e-02	8.83e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	21	5.03e-01	-8.44e-02	8.83e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	29	5.09e-01	7.09e-02	8.91e-01
REACTOME SYNTHESIS OF 5 EICOSATETRAENOIC ACIDS	9	5.09e-01	-1.27e-01	8.91e-01
REACTOME METABOLISM OF LIPIDS	709	5.10e-01	1.45e-02	8.91e-01
REACTOME FANCONI ANEMIA PATHWAY	35	5.11e-01	-6.43e-02	8.91e-01
REACTOME CROSS PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS PHAGOSOMES	6	5.12e-01	1.55e-01	8.91e-01
REACTOME KSRP KHSRP BINDS AND DESTABILIZES MRNA	17	5.12e-01	9.19e-02	8.91e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	5.13e-01	9.77e-02	8.91e-01
REACTOME NGF STIMULATED TRANSCRIPTION	38	5.14e-01	-6.11e-02	8.91e-01
REACTOME CS DS DEGRADATION	12	5.14e-01	1.09e-01	8.91e-01
REACTOME INTEGRATION OF ENERGY METABOLISM	105	5.15e-01	3.68e-02	8.91e-01
REACTOME RAP1 SIGNALLING	16	5.15e-01	-9.40e-02	8.91e-01
REACTOME SPERM MOTILITY AND TAXES	9	5.16e-01	-1.25e-01	8.91e-01
REACTOME COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	98	5.16e-01	-3.79e-02	8.91e-01
REACTOME TERMINATION OF TRANSLESION DNA SYNTHESIS	32	5.16e-01	-6.63e-02	8.91e-01
REACTOME SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	8	5.17e-01	1.32e-01	8.91e-01
REACTOME SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	27	5.17e-01	-7.20e-02	8.91e-01
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	5.17e-01	-4.29e-02	8.91e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	18	5.18e-01	-8.79e-02	8.91e-01
REACTOME ADHERENS JUNCTIONS INTERACTIONS	33	5.19e-01	-6.49e-02	8.91e-01
REACTOME SYNTHESIS OF 15 EICOSATETRAENOIC ACID DERIVATIVES	6	5.19e-01	1.52e-01	8.91e-01
REACTOME MUCOPOLYSACCHARIDOSES	10	5.19e-01	-1.18e-01	8.91e-01
REACTOME CD209 DC SIGN SIGNALING	20	5.20e-01	-8.31e-02	8.91e-01
REACTOME CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	5.20e-01	-1.07e-01	8.91e-01
REACTOME RA BIOSYNTHESIS PATHWAY	22	5.23e-01	7.87e-02	8.91e-01
REACTOME AMINE LIGAND BINDING RECEPTORS	40	5.23e-01	5.84e-02	8.91e-01
REACTOME PINK1 PRKN MEDIATED MITOPHAGY	22	5.23e-01	7.86e-02	8.91e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	56	5.24e-01	-4.92e-02	8.91e-01
REACTOME DETOXIFICATION OF REACTIVE OXYGEN SPECIES	34	5.24e-01	6.31e-02	8.91e-01
REACTOME MET ACTIVATES PTK2 SIGNALING	30	5.24e-01	6.72e-02	8.91e-01
REACTOME INTERFERON SIGNALING	193	5.24e-01	2.66e-02	8.91e-01
REACTOME SUMOYLATION OF INTRACELLULAR RECEPTORS	29	5.24e-01	-6.83e-02	8.91e-01
REACTOME SIGNALING BY PDGF	57	5.26e-01	-4.86e-02	8.91e-01
REACTOME ACYL CHAIN REMODELING OF DAG AND TAG	5	5.26e-01	-1.64e-01	8.91e-01
REACTOME FORMATION OF XYLULOSE 5 PHOSPHATE	5	5.26e-01	1.64e-01	8.91e-01
REACTOME RORA ACTIVATES GENE EXPRESSION	17	5.27e-01	-8.87e-02	8.91e-01
REACTOME PEPTIDE HORMONE BIOSYNTHESIS	13	5.27e-01	1.01e-01	8.91e-01
REACTOME SIGNALING BY FGFR4 IN DISEASE	11	5.28e-01	-1.10e-01	8.91e-01
REACTOME PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	26	5.29e-01	-7.14e-02	8.91e-01
REACTOME PHASE 2 PLATEAU PHASE	14	5.30e-01	9.70e-02	8.91e-01
REACTOME PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	77	5.30e-01	4.14e-02	8.91e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	183	5.31e-01	-2.69e-02	8.91e-01
REACTOME TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	52	5.32e-01	-5.01e-02	8.91e-01
REACTOME P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1	6	5.32e-01	1.47e-01	8.91e-01
REACTOME RHOA GTPASE CYCLE	142	5.32e-01	3.03e-02	8.91e-01
REACTOME MYOGENESIS	29	5.32e-01	6.70e-02	8.91e-01
REACTOME REGULATION OF LIPID METABOLISM BY PPARALPHA	115	5.33e-01	3.37e-02	8.91e-01
REACTOME DISEASES OF METABOLISM	237	5.33e-01	-2.35e-02	8.91e-01
REACTOME TNFR1 INDUCED PROAPOPTOTIC SIGNALING	23	5.34e-01	7.49e-02	8.91e-01
REACTOME ABACAVIR TRANSMEMBRANE TRANSPORT	5	5.34e-01	-1.60e-01	8.91e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI	18	5.35e-01	8.44e-02	8.91e-01
REACTOME PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1	9	5.36e-01	-1.19e-01	8.91e-01
REACTOME POTENTIAL THERAPEUTICS FOR SARS	92	5.36e-01	3.73e-02	8.91e-01
REACTOME VITAMIN D CALCIFEROL METABOLISM	12	5.37e-01	1.03e-01	8.91e-01
REACTOME IRON UPTAKE AND TRANSPORT	56	5.38e-01	4.75e-02	8.91e-01
REACTOME RETINOID CYCLE DISEASE EVENTS	11	5.38e-01	1.07e-01	8.91e-01
REACTOME GLYCOGEN METABOLISM	22	5.39e-01	-7.57e-02	8.91e-01
REACTOME INTERLEUKIN 37 SIGNALING	20	5.39e-01	7.94e-02	8.91e-01
REACTOME INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	45	5.40e-01	-5.28e-02	8.91e-01
REACTOME SYNDECAN INTERACTIONS	26	5.40e-01	6.94e-02	8.91e-01
REACTOME SYNTHESIS OF PI	5	5.40e-01	1.58e-01	8.91e-01
REACTOME N GLYCAN ANTENNAE ELONGATION	15	5.41e-01	9.12e-02	8.91e-01
REACTOME P2Y RECEPTORS	9	5.41e-01	1.18e-01	8.91e-01
REACTOME NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER	18	5.42e-01	-8.31e-02	8.91e-01
REACTOME RHOG GTPASE CYCLE	71	5.42e-01	-4.19e-02	8.91e-01
REACTOME PEROXISOMAL LIPID METABOLISM	28	5.43e-01	-6.65e-02	8.91e-01
REACTOME BINDING OF TCF LEF CTNNB1 TO TARGET GENE PROMOTERS	8	5.47e-01	1.23e-01	8.96e-01
REACTOME EGFR DOWNREGULATION	30	5.48e-01	-6.34e-02	8.96e-01
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	15	5.48e-01	8.96e-02	8.96e-01
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	5.48e-01	-1.10e-01	8.96e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	26	5.49e-01	6.80e-02	8.96e-01
REACTOME CHREBP ACTIVATES METABOLIC GENE EXPRESSION	8	5.51e-01	-1.22e-01	8.99e-01
REACTOME PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	21	5.51e-01	-7.51e-02	8.99e-01
REACTOME PTK6 PROMOTES HIF1A STABILIZATION	6	5.53e-01	-1.40e-01	9.00e-01
REACTOME MAPK1 ERK2 ACTIVATION	9	5.54e-01	1.14e-01	9.00e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	5.55e-01	-6.33e-02	9.00e-01
REACTOME SPHINGOLIPID METABOLISM	84	5.55e-01	3.72e-02	9.00e-01
REACTOME HYALURONAN BIOSYNTHESIS AND EXPORT	5	5.56e-01	1.52e-01	9.00e-01
REACTOME GLYCOSPHINGOLIPID METABOLISM	39	5.56e-01	5.44e-02	9.00e-01
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	11	5.56e-01	-1.02e-01	9.00e-01
REACTOME ABACAVIR ADME	9	5.57e-01	-1.13e-01	9.00e-01
REACTOME SIGNALING BY RNF43 MUTANTS	8	5.57e-01	1.20e-01	9.00e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS	29	5.58e-01	6.29e-02	9.00e-01
REACTOME TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	29	5.59e-01	6.27e-02	9.01e-01
REACTOME SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	43	5.60e-01	5.14e-02	9.02e-01
REACTOME OLFACTORY SIGNALING PATHWAY	348	5.61e-01	-1.81e-02	9.03e-01
REACTOME GASTRULATION	49	5.61e-01	-4.80e-02	9.03e-01
REACTOME VLDLR INTERNALISATION AND DEGRADATION	16	5.62e-01	-8.38e-02	9.03e-01
REACTOME REGULATION OF NPAS4 MRNA TRANSLATION	9	5.63e-01	1.11e-01	9.04e-01
REACTOME FLT3 SIGNALING BY CBL MUTANTS	7	5.64e-01	-1.26e-01	9.04e-01
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	9	5.66e-01	1.11e-01	9.05e-01
REACTOME FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	83	5.66e-01	-3.65e-02	9.05e-01
REACTOME TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	41	5.66e-01	-5.18e-02	9.05e-01
REACTOME IRAK4 DEFICIENCY TLR2 4	17	5.67e-01	-8.02e-02	9.05e-01
REACTOME ABC TRANSPORTERS IN LIPID HOMEOSTASIS	17	5.68e-01	-8.00e-02	9.05e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	48	5.68e-01	-4.76e-02	9.05e-01
REACTOME INTERLEUKIN 12 FAMILY SIGNALING	53	5.68e-01	4.53e-02	9.05e-01
REACTOME POTASSIUM CHANNELS	102	5.70e-01	3.25e-02	9.07e-01
REACTOME NEGATIVE REGULATION OF FLT3	15	5.72e-01	-8.43e-02	9.09e-01
REACTOME BUTYROPHILIN BTN FAMILY INTERACTIONS	12	5.73e-01	-9.41e-02	9.09e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	5.73e-01	-4.14e-02	9.09e-01
REACTOME SIGNALING BY FGFR2 IN DISEASE	42	5.74e-01	5.01e-02	9.09e-01
REACTOME FRUCTOSE CATABOLISM	5	5.74e-01	1.45e-01	9.09e-01
REACTOME SIGNALING BY LEPTIN	11	5.75e-01	9.75e-02	9.09e-01
REACTOME REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS	7	5.76e-01	1.22e-01	9.09e-01
REACTOME BIOSYNTHESIS OF MARESIN LIKE SPMS	6	5.76e-01	-1.32e-01	9.09e-01
REACTOME ACYL CHAIN REMODELING OF CL	5	5.76e-01	1.44e-01	9.09e-01
REACTOME LINOLEIC ACID LA METABOLISM	7	5.77e-01	1.22e-01	9.10e-01
REACTOME SYNTHESIS OF PA	38	5.78e-01	-5.22e-02	9.10e-01
REACTOME CYP2E1 REACTIONS	10	5.79e-01	-1.01e-01	9.11e-01
REACTOME TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	43	5.81e-01	-4.87e-02	9.12e-01
REACTOME COLLAGEN FORMATION	88	5.82e-01	3.39e-02	9.12e-01
REACTOME ATTACHMENT OF GPI ANCHOR TO UPAR	7	5.82e-01	1.20e-01	9.12e-01
REACTOME PROLACTIN RECEPTOR SIGNALING	15	5.83e-01	-8.20e-02	9.12e-01
REACTOME DISEASES ASSOCIATED WITH SURFACTANT METABOLISM	9	5.83e-01	1.06e-01	9.12e-01
REACTOME DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS	25	5.83e-01	-6.34e-02	9.12e-01
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	26	5.85e-01	6.19e-02	9.12e-01
REACTOME ARYL HYDROCARBON RECEPTOR SIGNALLING	6	5.85e-01	1.29e-01	9.12e-01
REACTOME SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA PHE	6	5.85e-01	-1.29e-01	9.12e-01
REACTOME RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	5.87e-01	8.39e-02	9.14e-01
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	51	5.87e-01	4.39e-02	9.14e-01
REACTOME CIPROFLOXACIN ADME	5	5.88e-01	1.40e-01	9.15e-01
REACTOME GABA B RECEPTOR ACTIVATION	43	5.90e-01	-4.75e-02	9.16e-01
REACTOME INACTIVATION OF CDC42 AND RAC1	8	5.90e-01	-1.10e-01	9.16e-01
REACTOME LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX	5	5.91e-01	1.39e-01	9.16e-01
REACTOME MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	17	5.91e-01	7.53e-02	9.16e-01
REACTOME SUPPRESSION OF APOPTOSIS	7	5.92e-01	-1.17e-01	9.16e-01
REACTOME INOSITOL PHOSPHATE METABOLISM	45	5.94e-01	4.60e-02	9.18e-01
REACTOME SARS COV 2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES	118	5.96e-01	-2.83e-02	9.20e-01
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	118	5.96e-01	2.82e-02	9.20e-01
REACTOME RHO GTPASES ACTIVATE IQGAPS	31	5.97e-01	-5.49e-02	9.20e-01
REACTOME FGFR2B LIGAND BINDING AND ACTIVATION	10	5.99e-01	9.60e-02	9.23e-01
REACTOME PTK6 EXPRESSION	5	6.01e-01	1.35e-01	9.24e-01
REACTOME LIPID PARTICLE ORGANIZATION	6	6.01e-01	1.23e-01	9.24e-01
REACTOME VITAMINS	6	6.01e-01	1.23e-01	9.24e-01
REACTOME SIGNALING BY MST1	5	6.02e-01	1.35e-01	9.24e-01
REACTOME RHO GTPASES ACTIVATE CIT	19	6.04e-01	6.87e-02	9.25e-01
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	6.05e-01	9.46e-02	9.25e-01
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	7	6.06e-01	-1.13e-01	9.25e-01
REACTOME ACETYLCHOLINE REGULATES INSULIN SECRETION	10	6.06e-01	9.42e-02	9.25e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS	7	6.06e-01	-1.12e-01	9.25e-01
REACTOME RAC2 GTPASE CYCLE	81	6.06e-01	-3.31e-02	9.25e-01
REACTOME SLC TRANSPORTER DISORDERS	94	6.08e-01	3.06e-02	9.26e-01
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS	6	6.08e-01	1.21e-01	9.26e-01
REACTOME P38MAPK EVENTS	13	6.09e-01	-8.19e-02	9.26e-01
REACTOME HSF1 DEPENDENT TRANSACTIVATION	37	6.09e-01	4.85e-02	9.26e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS	36	6.10e-01	4.92e-02	9.26e-01
REACTOME POST TRANSCRIPTIONAL SILENCING BY SMALL RNAS	7	6.10e-01	1.11e-01	9.26e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	36	6.11e-01	-4.90e-02	9.27e-01
REACTOME ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	6.12e-01	-9.25e-02	9.27e-01
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	15	6.13e-01	-7.54e-02	9.27e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	29	6.13e-01	5.42e-02	9.27e-01
REACTOME RND3 GTPASE CYCLE	41	6.14e-01	-4.55e-02	9.27e-01
REACTOME FRS MEDIATED FGFR3 SIGNALING	19	6.15e-01	6.66e-02	9.27e-01
REACTOME REGULATION OF IFNA IFNB SIGNALING	23	6.16e-01	6.04e-02	9.27e-01
REACTOME INTERLEUKIN RECEPTOR SHC SIGNALING	24	6.16e-01	5.91e-02	9.27e-01
REACTOME DIGESTION OF DIETARY CARBOHYDRATE	6	6.17e-01	-1.18e-01	9.27e-01
REACTOME MRNA CAPPING	28	6.17e-01	-5.46e-02	9.27e-01
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS	10	6.18e-01	-9.10e-02	9.27e-01
REACTOME PENTOSE PHOSPHATE PATHWAY	12	6.18e-01	8.30e-02	9.27e-01
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	6.19e-01	6.43e-02	9.27e-01
REACTOME MRNA EDITING	10	6.20e-01	9.06e-02	9.27e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	20	6.21e-01	6.39e-02	9.27e-01
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	16	6.22e-01	-7.13e-02	9.27e-01
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	15	6.22e-01	7.35e-02	9.27e-01
REACTOME AMINO ACID CONJUGATION	9	6.22e-01	-9.48e-02	9.27e-01
REACTOME ETHANOL OXIDATION	12	6.22e-01	-8.21e-02	9.27e-01
REACTOME APOPTOTIC EXECUTION PHASE	49	6.23e-01	-4.06e-02	9.27e-01
REACTOME EXTENSION OF TELOMERES	49	6.23e-01	-4.06e-02	9.27e-01
REACTOME GLYCEROPHOSPHOLIPID CATABOLISM	7	6.23e-01	1.07e-01	9.27e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS	11	6.25e-01	-8.51e-02	9.28e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	6.26e-01	-7.53e-02	9.28e-01
REACTOME MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	6.27e-01	-7.79e-02	9.28e-01
REACTOME SOS MEDIATED SIGNALLING	7	6.28e-01	-1.06e-01	9.28e-01
REACTOME TRANSPORT OF NUCLEOTIDE SUGARS	8	6.28e-01	9.89e-02	9.28e-01
REACTOME FRUCTOSE METABOLISM	7	6.28e-01	1.06e-01	9.28e-01
REACTOME NEUROTRANSMITTER CLEARANCE	9	6.29e-01	9.31e-02	9.28e-01
REACTOME ECM PROTEOGLYCANS	73	6.29e-01	3.27e-02	9.28e-01
REACTOME REGULATION BY C FLIP	11	6.29e-01	8.41e-02	9.28e-01
REACTOME NRCAM INTERACTIONS	6	6.30e-01	1.13e-01	9.29e-01
REACTOME ACYL CHAIN REMODELLING OF PC	27	6.32e-01	5.33e-02	9.29e-01
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	16	6.32e-01	-6.92e-02	9.29e-01
REACTOME CA2 PATHWAY	62	6.32e-01	-3.52e-02	9.29e-01
REACTOME RAB GEFS EXCHANGE GTP FOR GDP ON RABS	81	6.32e-01	3.07e-02	9.29e-01
REACTOME NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	24	6.33e-01	5.63e-02	9.29e-01
REACTOME FRS MEDIATED FGFR1 SIGNALING	23	6.35e-01	5.72e-02	9.30e-01
REACTOME IRAK1 RECRUITS IKK COMPLEX	12	6.35e-01	-7.92e-02	9.30e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	29	6.36e-01	5.07e-02	9.31e-01
REACTOME NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	12	6.38e-01	-7.84e-02	9.31e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS	26	6.38e-01	-5.33e-02	9.31e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS	61	6.38e-01	3.48e-02	9.31e-01
REACTOME INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	20	6.39e-01	-6.06e-02	9.31e-01
REACTOME LAGGING STRAND SYNTHESIS	19	6.40e-01	-6.20e-02	9.31e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	20	6.41e-01	-6.03e-02	9.31e-01
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA PLCG	7	6.41e-01	-1.02e-01	9.31e-01
REACTOME OTHER INTERLEUKIN SIGNALING	24	6.41e-01	5.50e-02	9.31e-01
REACTOME SUMO IS TRANSFERRED FROM E1 TO E2 UBE2I UBC9	7	6.42e-01	-1.02e-01	9.32e-01
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	6.43e-01	-7.74e-02	9.32e-01
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	21	6.43e-01	-5.84e-02	9.32e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	6.44e-01	3.74e-02	9.32e-01
REACTOME SPRY REGULATION OF FGF SIGNALING	16	6.45e-01	-6.66e-02	9.33e-01
REACTOME CROSSLINKING OF COLLAGEN FIBRILS	16	6.48e-01	-6.58e-02	9.37e-01
REACTOME ENOS ACTIVATION	11	6.49e-01	-7.93e-02	9.37e-01
REACTOME RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS	5	6.49e-01	1.17e-01	9.37e-01
REACTOME SIGNALING BY ALK	26	6.50e-01	-5.14e-02	9.37e-01
REACTOME ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	11	6.51e-01	-7.89e-02	9.37e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE GIP	12	6.56e-01	-7.43e-02	9.44e-01
REACTOME MET ACTIVATES RAP1 AND RAC1	11	6.57e-01	7.74e-02	9.44e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	6.57e-01	-5.13e-02	9.44e-01
REACTOME RHOT1 GTPASE CYCLE	5	6.59e-01	-1.14e-01	9.45e-01
REACTOME RHO GTPASES ACTIVATE WASPS AND WAVES	34	6.60e-01	-4.36e-02	9.45e-01
REACTOME GRB7 EVENTS IN ERBB2 SIGNALING	5	6.60e-01	-1.14e-01	9.45e-01
REACTOME SIGNALING BY NOTCH1 T 7 9 NOTCH1 M1580 K2555 TRANSLOCATION MUTANT	7	6.61e-01	-9.59e-02	9.46e-01
REACTOME MICRORNA MIRNA BIOGENESIS	25	6.62e-01	5.05e-02	9.46e-01
REACTOME RAB REGULATION OF TRAFFICKING	110	6.63e-01	2.41e-02	9.46e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION TERMINATION	30	6.63e-01	-4.59e-02	9.46e-01
REACTOME PYRIMIDINE CATABOLISM	12	6.64e-01	7.25e-02	9.46e-01
REACTOME MET RECEPTOR RECYCLING	10	6.64e-01	7.94e-02	9.46e-01
REACTOME SIGNALING BY FGFR	85	6.65e-01	-2.71e-02	9.47e-01
REACTOME SMALL INTERFERING RNA SIRNA BIOGENESIS	9	6.67e-01	8.29e-02	9.49e-01
REACTOME RIP MEDIATED NFKB ACTIVATION VIA ZBP1	16	6.69e-01	6.18e-02	9.50e-01
REACTOME INTERLEUKIN 6 SIGNALING	11	6.69e-01	7.44e-02	9.50e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING	30	6.70e-01	-4.49e-02	9.50e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	29	6.70e-01	-4.57e-02	9.50e-01
REACTOME RHOD GTPASE CYCLE	49	6.71e-01	-3.51e-02	9.50e-01
REACTOME LRR FLII INTERACTING PROTEIN 1 LRRFIP1 ACTIVATES TYPE I IFN PRODUCTION	5	6.73e-01	1.09e-01	9.51e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	31	6.73e-01	4.38e-02	9.51e-01
REACTOME SENSING OF DNA DOUBLE STRAND BREAKS	6	6.74e-01	-9.90e-02	9.52e-01
REACTOME TRANSPORT OF FATTY ACIDS	8	6.75e-01	8.57e-02	9.52e-01
REACTOME PD 1 SIGNALING	21	6.75e-01	5.28e-02	9.52e-01
REACTOME RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES TREGS	9	6.76e-01	8.06e-02	9.52e-01
REACTOME SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	15	6.76e-01	6.23e-02	9.52e-01
REACTOME NUCLEOTIDE CATABOLISM	35	6.80e-01	-4.03e-02	9.55e-01
REACTOME RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	6.80e-01	-2.46e-02	9.55e-01
REACTOME AMINO ACIDS REGULATE MTORC1	53	6.80e-01	3.28e-02	9.55e-01
REACTOME SCAVENGING OF HEME FROM PLASMA	13	6.81e-01	-6.59e-02	9.55e-01
REACTOME NOSTRIN MEDIATED ENOS TRAFFICKING	5	6.82e-01	1.06e-01	9.55e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	91	6.82e-01	-2.48e-02	9.55e-01
REACTOME DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B	7	6.83e-01	8.92e-02	9.55e-01
REACTOME RRNA MODIFICATION IN THE MITOCHONDRION	6	6.85e-01	9.56e-02	9.55e-01
REACTOME NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	25	6.88e-01	4.63e-02	9.55e-01
REACTOME ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	23	6.89e-01	4.82e-02	9.55e-01
REACTOME COSTIMULATION BY THE CD28 FAMILY	64	6.90e-01	2.88e-02	9.55e-01
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	24	6.91e-01	4.69e-02	9.55e-01
REACTOME TNF SIGNALING	54	6.91e-01	-3.12e-02	9.55e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH PI3K	7	6.91e-01	8.66e-02	9.55e-01
REACTOME LAMININ INTERACTIONS	28	6.91e-01	-4.33e-02	9.55e-01
REACTOME TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	30	6.92e-01	4.17e-02	9.55e-01
REACTOME CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	6.93e-01	-6.87e-02	9.55e-01
REACTOME NR1H2 AND NR1H3 MEDIATED SIGNALING	46	6.94e-01	3.35e-02	9.55e-01
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	16	6.97e-01	5.63e-02	9.55e-01
REACTOME GAB1 SIGNALOSOME	17	6.97e-01	5.46e-02	9.55e-01
REACTOME ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	20	6.97e-01	5.02e-02	9.55e-01
REACTOME REPRESSION OF WNT TARGET GENES	14	6.97e-01	-6.00e-02	9.55e-01
REACTOME BICARBONATE TRANSPORTERS	10	6.98e-01	7.08e-02	9.55e-01
REACTOME REGULATION OF NF KAPPA B SIGNALING	17	6.98e-01	-5.43e-02	9.55e-01
REACTOME MITOTIC TELOPHASE CYTOKINESIS	11	7.00e-01	-6.71e-02	9.55e-01
REACTOME SIGNALING BY WNT IN CANCER	32	7.00e-01	3.93e-02	9.55e-01
REACTOME REGULATION OF SIGNALING BY NODAL	9	7.00e-01	7.41e-02	9.55e-01
REACTOME RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	19	7.01e-01	5.08e-02	9.55e-01
REACTOME PHASE II CONJUGATION OF COMPOUNDS	102	7.02e-01	-2.19e-02	9.55e-01
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	7.02e-01	4.18e-02	9.55e-01
REACTOME MRNA SPLICING MINOR PATHWAY	49	7.03e-01	-3.15e-02	9.55e-01
REACTOME ENDOGENOUS STEROLS	26	7.03e-01	4.32e-02	9.55e-01
REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX	32	7.03e-01	-3.89e-02	9.55e-01
REACTOME TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	36	7.05e-01	-3.65e-02	9.55e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	16	7.05e-01	5.47e-02	9.55e-01
REACTOME BETA OXIDATION OF BUTANOYL COA TO ACETYL COA	5	7.05e-01	-9.78e-02	9.55e-01
REACTOME REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	7.05e-01	-5.65e-02	9.55e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	11	7.05e-01	-6.58e-02	9.55e-01
REACTOME BIOSYNTHESIS OF MARESINS	8	7.06e-01	-7.71e-02	9.55e-01
REACTOME ACYL CHAIN REMODELLING OF PE	29	7.07e-01	-4.04e-02	9.55e-01
REACTOME INNATE IMMUNE SYSTEM	1002	7.07e-01	7.01e-03	9.55e-01
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	14	7.07e-01	-5.79e-02	9.55e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	21	7.08e-01	4.73e-02	9.55e-01
REACTOMEMATURATION OF SARS COV 1 NUCLEOPROTEIN	11	7.08e-01	-6.53e-02	9.55e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX IN CANCER	8	7.08e-01	-7.65e-02	9.55e-01
REACTOME RECEPTOR MEDIATED MITOPHAGY	10	7.09e-01	-6.81e-02	9.55e-01
REACTOME ATORVASTATIN ADME	9	7.09e-01	7.17e-02	9.55e-01
REACTOME TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	14	7.10e-01	-5.74e-02	9.55e-01
REACTOME SIGNALING BY MAPK MUTANTS	6	7.10e-01	-8.76e-02	9.55e-01
REACTOME GAP JUNCTION DEGRADATION	12	7.10e-01	-6.20e-02	9.55e-01
REACTOME CIRCADIAN CLOCK	68	7.10e-01	-2.60e-02	9.55e-01
REACTOME INTERLEUKIN 35 SIGNALLING	12	7.12e-01	6.16e-02	9.55e-01
REACTOME SYNTHESIS OF EPOXY EET AND DIHYDROXYEICOSATRIENOIC ACIDS DHET	8	7.12e-01	-7.54e-02	9.55e-01
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	57	7.12e-01	-2.83e-02	9.55e-01
REACTOME SARS COV 1 MODULATES HOST TRANSLATION MACHINERY	33	7.12e-01	-3.71e-02	9.55e-01
REACTOME IRF3 MEDIATED INDUCTION OF TYPE I IFN	13	7.12e-01	-5.91e-02	9.55e-01
REACTOME INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	25	7.12e-01	4.26e-02	9.55e-01
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	7.12e-01	6.42e-02	9.55e-01
REACTOME SIGNALING BY FGFR IN DISEASE	62	7.13e-01	2.70e-02	9.55e-01
REACTOME NEPHRIN FAMILY INTERACTIONS	22	7.14e-01	-4.52e-02	9.55e-01
REACTOME SIGNALING BY SCF KIT	42	7.14e-01	-3.27e-02	9.55e-01
REACTOME TRIF MEDIATED PROGRAMMED CELL DEATH	9	7.15e-01	7.02e-02	9.55e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	14	7.16e-01	5.62e-02	9.55e-01
REACTOME MET ACTIVATES RAS SIGNALING	11	7.17e-01	6.32e-02	9.55e-01
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	67	7.17e-01	2.56e-02	9.55e-01
REACTOME BETA DEFENSINS	27	7.18e-01	4.02e-02	9.55e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	7.18e-01	-6.28e-02	9.55e-01
REACTOME RHOBTB2 GTPASE CYCLE	22	7.18e-01	-4.44e-02	9.55e-01
REACTOME SERINE BIOSYNTHESIS	9	7.19e-01	6.92e-02	9.55e-01
REACTOME SIGNALLING TO RAS	20	7.19e-01	-4.64e-02	9.55e-01
REACTOME MTOR SIGNALLING	40	7.20e-01	-3.28e-02	9.55e-01
REACTOME LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	11	7.21e-01	-6.22e-02	9.55e-01
REACTOME EPH EPHRIN MEDIATED REPULSION OF CELLS	50	7.21e-01	2.92e-02	9.55e-01
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	16	7.21e-01	5.15e-02	9.55e-01
REACTOME DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	30	7.22e-01	-3.76e-02	9.55e-01
REACTOME NETRIN 1 SIGNALING	49	7.24e-01	2.92e-02	9.57e-01
REACTOME TRANSPORT OF RCBL WITHIN THE BODY	8	7.25e-01	-7.18e-02	9.58e-01
REACTOME NICOTINAMIDE SALVAGING	19	7.26e-01	-4.65e-02	9.58e-01
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	7.27e-01	4.89e-02	9.59e-01
REACTOME NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	193	7.28e-01	-1.45e-02	9.59e-01
REACTOME SIGNALING BY NODAL	20	7.29e-01	4.48e-02	9.59e-01
REACTOME REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA CARBOXYLATED PROTEINS	8	7.30e-01	-7.05e-02	9.60e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM	118	7.30e-01	-1.84e-02	9.60e-01
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	19	7.31e-01	4.56e-02	9.60e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	30	7.32e-01	3.61e-02	9.61e-01
REACTOME RESPONSE OF MTB TO PHAGOCYTOSIS	22	7.33e-01	4.20e-02	9.61e-01
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	9	7.33e-01	-6.56e-02	9.61e-01
REACTOME FORMATION OF APOPTOSOME	10	7.35e-01	-6.19e-02	9.61e-01
REACTOME TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	7.35e-01	-5.65e-02	9.61e-01
REACTOME PROTEIN METHYLATION	17	7.37e-01	4.71e-02	9.63e-01
REACTOME NUCLEOTIDE BIOSYNTHESIS	14	7.37e-01	-5.19e-02	9.63e-01
REACTOME TRAF6 MEDIATED NF KB ACTIVATION	24	7.40e-01	3.92e-02	9.65e-01
REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	9	7.41e-01	-6.36e-02	9.65e-01
REACTOME DERMATAN SULFATE BIOSYNTHESIS	10	7.41e-01	6.03e-02	9.65e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	25	7.41e-01	-3.82e-02	9.65e-01
REACTOME MAP2K AND MAPK ACTIVATION	38	7.43e-01	3.08e-02	9.65e-01
REACTOME COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	65	7.43e-01	2.35e-02	9.65e-01
REACTOME TLR3 MEDIATED TICAM1 DEPENDENT PROGRAMMED CELL DEATH	6	7.43e-01	-7.72e-02	9.65e-01
REACTOME MRNA EDITING C TO U CONVERSION	8	7.43e-01	-6.69e-02	9.65e-01
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	53	7.44e-01	-2.59e-02	9.65e-01
REACTOME TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION	5	7.45e-01	-8.41e-02	9.65e-01
REACTOME ARACHIDONATE PRODUCTION FROM DAG	5	7.46e-01	-8.38e-02	9.66e-01
REACTOME FIBRONECTIN MATRIX FORMATION	6	7.47e-01	7.61e-02	9.66e-01
REACTOME PEPTIDE HORMONE METABOLISM	84	7.47e-01	2.04e-02	9.66e-01
REACTOME ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	7.49e-01	-3.85e-02	9.67e-01
REACTOME DISEASES OF GLYCOSYLATION	137	7.49e-01	1.58e-02	9.67e-01
REACTOME NTRK2 ACTIVATES RAC1	5	7.50e-01	-8.24e-02	9.67e-01
REACTOME GLUTAMATE AND GLUTAMINE METABOLISM	13	7.52e-01	-5.05e-02	9.69e-01
REACTOME BETA OXIDATION OF PRISTANOYL COA	9	7.53e-01	-6.05e-02	9.69e-01
REACTOME CRMPS IN SEMA3A SIGNALING	15	7.54e-01	4.67e-02	9.69e-01
REACTOME RHOQ GTPASE CYCLE	57	7.55e-01	-2.39e-02	9.69e-01
REACTOME MITOCHONDRIAL UNCOUPLING	5	7.55e-01	-8.06e-02	9.69e-01
REACTOME HEME BIOSYNTHESIS	13	7.55e-01	5.00e-02	9.69e-01
REACTOME KETONE BODY METABOLISM	9	7.57e-01	5.95e-02	9.70e-01
REACTOME SYNTHESIS OF PC	27	7.58e-01	-3.43e-02	9.70e-01
REACTOME RIPK1 MEDIATED REGULATED NECROSIS	30	7.58e-01	-3.25e-02	9.70e-01
REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	7.58e-01	5.37e-02	9.70e-01
REACTOME TBC RABGAPS	40	7.58e-01	2.81e-02	9.70e-01
REACTOME REGULATION OF TLR BY ENDOGENOUS LIGAND	21	7.59e-01	3.86e-02	9.70e-01
REACTOME REGULATION OF SIGNALING BY CBL	22	7.60e-01	-3.77e-02	9.70e-01
REACTOME CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	12	7.62e-01	-5.04e-02	9.71e-01
REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	7.64e-01	-4.21e-02	9.71e-01
REACTOME MISCELLANEOUS TRANSPORT AND BINDING EVENTS	24	7.64e-01	-3.54e-02	9.71e-01
REACTOME LIGAND RECEPTOR INTERACTIONS	8	7.64e-01	-6.12e-02	9.71e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	25	7.67e-01	-3.42e-02	9.71e-01
REACTOME RRNA PROCESSING IN THE MITOCHONDRION	9	7.69e-01	5.65e-02	9.71e-01
REACTOME DEPOLYMERISATION OF THE NUCLEAR LAMINA	14	7.69e-01	-4.53e-02	9.71e-01
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE	29	7.70e-01	3.14e-02	9.71e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	44	7.70e-01	-2.54e-02	9.71e-01
REACTOME SIGNALING BY NTRK2 TRKB	25	7.71e-01	-3.36e-02	9.71e-01
REACTOME MET INTERACTS WITH TNS PROTEINS	5	7.72e-01	7.47e-02	9.71e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES	8	7.73e-01	-5.90e-02	9.71e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	24	7.73e-01	-3.40e-02	9.71e-01
REACTOME MISMATCH REPAIR	15	7.74e-01	-4.29e-02	9.71e-01
REACTOME STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	7.74e-01	5.25e-02	9.71e-01
REACTOME ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	24	7.74e-01	-3.38e-02	9.71e-01
REACTOME OPSINS	7	7.76e-01	-6.22e-02	9.71e-01
REACTOME AUTOPHAGY	144	7.77e-01	-1.37e-02	9.71e-01
REACTOME RHOB GTPASE CYCLE	67	7.77e-01	2.00e-02	9.71e-01
REACTOME LGI ADAM INTERACTIONS	14	7.78e-01	4.35e-02	9.71e-01
REACTOME RUNX2 REGULATES CHONDROCYTE MATURATION	5	7.80e-01	7.22e-02	9.71e-01
REACTOME RECYCLING OF EIF2 GDP	7	7.81e-01	-6.07e-02	9.71e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	20	7.81e-01	3.58e-02	9.71e-01
REACTOME PHASE I FUNCTIONALIZATION OF COMPOUNDS	101	7.81e-01	1.60e-02	9.71e-01
REACTOME KINESINS	59	7.82e-01	-2.08e-02	9.71e-01
REACTOME SIGNALING BY FGFR2	72	7.82e-01	-1.88e-02	9.71e-01
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	23	7.82e-01	-3.33e-02	9.71e-01
REACTOME RHO GTPASES ACTIVATE PAKS	19	7.83e-01	-3.66e-02	9.71e-01
REACTOME MASTL FACILITATES MITOTIC PROGRESSION	10	7.83e-01	5.04e-02	9.71e-01
REACTOME SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	17	7.83e-01	3.86e-02	9.71e-01
REACTOME ATTACHMENT AND ENTRY	16	7.83e-01	-3.97e-02	9.71e-01
REACTOME DEFECTS IN BIOTIN BTN METABOLISM	8	7.84e-01	-5.60e-02	9.71e-01
REACTOME MOLYBDENUM COFACTOR BIOSYNTHESIS	6	7.84e-01	6.46e-02	9.71e-01
REACTOME LYSOSPHINGOLIPID AND LPA RECEPTORS	14	7.85e-01	-4.21e-02	9.71e-01
REACTOME CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	9	7.85e-01	5.24e-02	9.71e-01
REACTOME TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	7.86e-01	-3.70e-02	9.71e-01
REACTOME EUKARYOTIC TRANSLATION INITIATION	110	7.86e-01	-1.50e-02	9.71e-01
REACTOME DSCAM INTERACTIONS	11	7.86e-01	4.72e-02	9.71e-01
REACTOME HEME SIGNALING	47	7.87e-01	-2.28e-02	9.71e-01
REACTOME DAP12 INTERACTIONS	37	7.88e-01	-2.55e-02	9.71e-01
REACTOME FBXW7 MUTANTS AND NOTCH1 IN CANCER	5	7.88e-01	-6.93e-02	9.71e-01
REACTOME PTK6 REGULATES CELL CYCLE	6	7.88e-01	-6.33e-02	9.71e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	13	7.88e-01	-4.30e-02	9.71e-01
REACTOME PREDNISONE ADME	10	7.90e-01	-4.88e-02	9.71e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	7.90e-01	3.98e-02	9.71e-01
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS	5	7.91e-01	6.85e-02	9.71e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION	121	7.91e-01	-1.40e-02	9.71e-01
REACTOME NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	7.91e-01	-4.62e-02	9.71e-01
REACTOME DEFENSINS	33	7.91e-01	2.66e-02	9.71e-01
REACTOME ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	87	7.92e-01	1.64e-02	9.71e-01
REACTOME VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	7.94e-01	-2.96e-02	9.71e-01
REACTOME G ALPHA Z SIGNALLING EVENTS	48	7.94e-01	2.18e-02	9.71e-01
REACTOME FERTILIZATION	26	7.94e-01	-2.96e-02	9.71e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	45	7.97e-01	2.22e-02	9.71e-01
REACTOME HYALURONAN METABOLISM	17	7.97e-01	-3.60e-02	9.71e-01
REACTOME CELLULAR HEXOSE TRANSPORT	21	7.97e-01	3.24e-02	9.71e-01
REACTOME G PROTEIN ACTIVATION	24	7.98e-01	3.02e-02	9.71e-01
REACTOME DOPAMINE RECEPTORS	5	7.98e-01	-6.61e-02	9.71e-01
REACTOME NOD1 2 SIGNALING PATHWAY	33	7.99e-01	-2.57e-02	9.71e-01
REACTOME TRANSCRIPTIONAL REGULATION BY VENTX	41	7.99e-01	2.30e-02	9.71e-01
REACTOME BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	17	7.99e-01	3.56e-02	9.71e-01
REACTOME RHOH GTPASE CYCLE	37	8.00e-01	-2.41e-02	9.71e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	38	8.00e-01	2.38e-02	9.71e-01
REACTOME RND1 GTPASE CYCLE	41	8.00e-01	-2.29e-02	9.71e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	24	8.00e-01	-2.98e-02	9.71e-01
REACTOME NONCANONICAL ACTIVATION OF NOTCH3	8	8.01e-01	-5.14e-02	9.71e-01
REACTOME CD163 MEDIATING AN ANTI INFLAMMATORY RESPONSE	9	8.01e-01	-4.84e-02	9.71e-01
REACTOME ESTABLISHMENT OF SISTER CHROMATID COHESION	9	8.02e-01	-4.84e-02	9.71e-01
REACTOME LIPOPHAGY	9	8.02e-01	-4.82e-02	9.71e-01
REACTOME PI3K AKT ACTIVATION	9	8.02e-01	4.82e-02	9.71e-01
REACTOME HS GAG DEGRADATION	19	8.04e-01	-3.30e-02	9.71e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	353	8.05e-01	-7.66e-03	9.71e-01
REACTOME UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES	9	8.06e-01	4.72e-02	9.71e-01
REACTOME ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION	10	8.06e-01	-4.48e-02	9.71e-01
REACTOME NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	11	8.07e-01	-4.25e-02	9.71e-01
REACTOME REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	8.10e-01	3.37e-02	9.71e-01
REACTOME NONSENSE MEDIATED DECAY NMD	107	8.10e-01	1.35e-02	9.71e-01
REACTOME PKA ACTIVATION IN GLUCAGON SIGNALLING	17	8.11e-01	-3.35e-02	9.71e-01
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	14	8.11e-01	3.69e-02	9.71e-01
REACTOME OTHER SEMAPHORIN INTERACTIONS	18	8.11e-01	3.26e-02	9.71e-01
REACTOME SIGNALING BY MRAS COMPLEX MUTANTS	7	8.11e-01	5.21e-02	9.71e-01
REACTOME ATTENUATION PHASE	27	8.11e-01	-2.65e-02	9.71e-01
REACTOME RND2 GTPASE CYCLE	42	8.12e-01	-2.12e-02	9.71e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS	8	8.12e-01	4.85e-02	9.71e-01
REACTOME GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION	7	8.13e-01	5.15e-02	9.71e-01
REACTOME ACYL CHAIN REMODELLING OF PG	18	8.13e-01	-3.21e-02	9.71e-01
REACTOME NERVOUS SYSTEM DEVELOPMENT	552	8.14e-01	5.87e-03	9.71e-01
REACTOME METALLOTHIONEINS BIND METALS	11	8.15e-01	4.06e-02	9.71e-01
REACTOME SODIUM CALCIUM EXCHANGERS	11	8.16e-01	4.06e-02	9.71e-01
REACTOME REGULATION OF PTEN LOCALIZATION	8	8.16e-01	4.76e-02	9.71e-01
REACTOME NADE MODULATES DEATH SIGNALLING	5	8.16e-01	6.01e-02	9.71e-01
REACTOME NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	22	8.16e-01	2.87e-02	9.71e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	24	8.16e-01	2.74e-02	9.71e-01
REACTOME G2 M DNA REPLICATION CHECKPOINT	5	8.16e-01	-6.00e-02	9.71e-01
REACTOME AZATHIOPRINE ADME	22	8.18e-01	-2.83e-02	9.72e-01
REACTOME INTRACELLULAR SIGNALING BY SECOND MESSENGERS	299	8.18e-01	7.72e-03	9.72e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	14	8.20e-01	-3.51e-02	9.72e-01
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	14	8.21e-01	3.50e-02	9.72e-01
REACTOME CREB3 FACTORS ACTIVATE GENES	8	8.22e-01	-4.60e-02	9.72e-01
REACTOME INTERLEUKIN 12 SIGNALING	43	8.22e-01	1.98e-02	9.72e-01
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	42	8.23e-01	2.00e-02	9.72e-01
REACTOME SYNTHESIS OF 16 20 HYDROXYEICOSATETRAENOIC ACIDS HETE	9	8.23e-01	4.31e-02	9.72e-01
REACTOME SIGNALING BY RETINOIC ACID	41	8.24e-01	2.01e-02	9.72e-01
REACTOME DIGESTION OF DIETARY LIPID	7	8.25e-01	4.82e-02	9.72e-01
REACTOME PURINE SALVAGE	12	8.26e-01	3.68e-02	9.72e-01
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	13	8.26e-01	-3.53e-02	9.72e-01
REACTOME CGMP EFFECTS	16	8.26e-01	3.17e-02	9.72e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27 HYDROXYCHOLESTEROL	15	8.27e-01	3.26e-02	9.72e-01
REACTOME INACTIVATION OF CSF3 G CSF SIGNALING	25	8.27e-01	2.52e-02	9.72e-01
REACTOME ALPHA OXIDATION OF PHYTANATE	6	8.27e-01	-5.14e-02	9.72e-01
REACTOME ACTIVATION OF NIMA KINASES NEK9 NEK6 NEK7	7	8.28e-01	-4.74e-02	9.72e-01
REACTOME ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS	5	8.29e-01	5.58e-02	9.72e-01
REACTOME TRAIL SIGNALING	8	8.29e-01	-4.41e-02	9.72e-01
REACTOME BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA	5	8.29e-01	5.57e-02	9.72e-01
REACTOME CREB PHOSPHORYLATION	6	8.30e-01	5.06e-02	9.72e-01
REACTOME MIRO GTPASE CYCLE	8	8.31e-01	4.35e-02	9.72e-01
REACTOME RUNX3 REGULATES NOTCH SIGNALING	13	8.32e-01	-3.40e-02	9.72e-01
REACTOME DEFECTIVE LFNG CAUSES SCDO3	5	8.32e-01	5.47e-02	9.72e-01
REACTOME INTERLEUKIN 36 PATHWAY	7	8.33e-01	4.60e-02	9.72e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	8.33e-01	3.14e-02	9.72e-01
REACTOME HEME DEGRADATION	15	8.34e-01	-3.13e-02	9.72e-01
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	30	8.36e-01	-2.18e-02	9.72e-01
REACTOME DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	19	8.37e-01	2.73e-02	9.72e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FYN	7	8.37e-01	-4.49e-02	9.72e-01
REACTOME INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	21	8.38e-01	-2.57e-02	9.72e-01
REACTOME SEMAPHORIN INTERACTIONS	61	8.39e-01	1.50e-02	9.72e-01
REACTOME SIGNALING BY NOTCH2	32	8.40e-01	-2.06e-02	9.72e-01
REACTOME RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	8.40e-01	-1.92e-02	9.72e-01
REACTOME SYNTHESIS OF PIPS AT THE ER MEMBRANE	5	8.40e-01	-5.21e-02	9.72e-01
REACTOME NEUROFASCIN INTERACTIONS	6	8.40e-01	-4.75e-02	9.72e-01
REACTOME MTORC1 MEDIATED SIGNALLING	23	8.41e-01	-2.41e-02	9.72e-01
REACTOME SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION	8	8.42e-01	4.06e-02	9.72e-01
REACTOME ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	8.43e-01	-3.31e-02	9.72e-01
REACTOME REGULATION OF PTEN MRNA TRANSLATION	9	8.44e-01	3.79e-02	9.72e-01
REACTOME CA2 ACTIVATED K CHANNELS	9	8.44e-01	3.79e-02	9.72e-01
REACTOME DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1	9	8.44e-01	3.79e-02	9.72e-01
REACTOME AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY	8	8.44e-01	-4.01e-02	9.72e-01
REACTOME GLUTATHIONE SYNTHESIS AND RECYCLING	12	8.45e-01	-3.26e-02	9.72e-01
REACTOME NETRIN MEDIATED REPULSION SIGNALS	8	8.45e-01	-3.99e-02	9.72e-01
REACTOME METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	8.45e-01	-2.91e-02	9.72e-01
REACTOME SODIUM COUPLED PHOSPHATE COTRANSPORTERS	5	8.46e-01	-5.01e-02	9.72e-01
REACTOME NEF AND SIGNAL TRANSDUCTION	8	8.47e-01	3.94e-02	9.72e-01
REACTOME DEX H BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION	7	8.47e-01	-4.21e-02	9.72e-01
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	13	8.48e-01	3.08e-02	9.72e-01
REACTOME THYROXINE BIOSYNTHESIS	10	8.48e-01	3.50e-02	9.72e-01
REACTOME INTERLEUKIN 1 PROCESSING	9	8.49e-01	-3.68e-02	9.72e-01
REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	17	8.49e-01	-2.66e-02	9.72e-01
REACTOME ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	28	8.50e-01	2.07e-02	9.72e-01
REACTOME SIGNALING BY MEMBRANE TETHERED FUSIONS OF PDGFRA OR PDGFRB	5	8.50e-01	4.89e-02	9.72e-01
REACTOME CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	100	8.51e-01	-1.09e-02	9.73e-01
REACTOME REGULATION OF TP53 EXPRESSION AND DEGRADATION	37	8.53e-01	-1.76e-02	9.73e-01
REACTOME HORMONE LIGAND BINDING RECEPTORS	12	8.53e-01	3.09e-02	9.73e-01
REACTOME PLATELET SENSITIZATION BY LDL	17	8.54e-01	2.58e-02	9.73e-01
REACTOME POU5F1 OCT4 SOX2 NANOG ACTIVATE GENES RELATED TO PROLIFERATION	11	8.54e-01	-3.21e-02	9.73e-01
REACTOME MITOPHAGY	28	8.54e-01	2.01e-02	9.73e-01
REACTOME PI METABOLISM	79	8.54e-01	-1.19e-02	9.73e-01
REACTOME INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	28	8.56e-01	-1.98e-02	9.73e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING	5	8.59e-01	-4.60e-02	9.73e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS	185	8.59e-01	7.55e-03	9.73e-01
REACTOME SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	54	8.60e-01	1.39e-02	9.73e-01
REACTOME CLATHRIN MEDIATED ENDOCYTOSIS	139	8.60e-01	-8.65e-03	9.73e-01
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	11	8.61e-01	3.06e-02	9.73e-01
REACTOME REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	8.61e-01	-3.20e-02	9.73e-01
REACTOME RAF ACTIVATION	33	8.61e-01	-1.76e-02	9.73e-01
REACTOME UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN	6	8.61e-01	-4.12e-02	9.73e-01
REACTOME DIGESTION	17	8.61e-01	2.45e-02	9.73e-01
REACTOME RELEASE OF HH NP FROM THE SECRETING CELL	8	8.62e-01	-3.55e-02	9.73e-01
REACTOME ACYL CHAIN REMODELLING OF PI	17	8.62e-01	2.43e-02	9.73e-01
REACTOME MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS	7	8.63e-01	3.76e-02	9.73e-01
REACTOME METHIONINE SALVAGE PATHWAY	6	8.63e-01	-4.06e-02	9.73e-01
REACTOME CONJUGATION OF BENZOATE WITH GLYCINE	6	8.64e-01	-4.03e-02	9.74e-01
REACTOME FOLDING OF ACTIN BY CCT TRIC	10	8.65e-01	-3.11e-02	9.74e-01
REACTOME IKBA VARIANT LEADS TO EDA ID	6	8.67e-01	3.95e-02	9.76e-01
REACTOME UNFOLDED PROTEIN RESPONSE UPR	88	8.68e-01	-1.02e-02	9.76e-01
REACTOME SIGNALING BY FGFR2 IIIA TM	19	8.69e-01	-2.19e-02	9.76e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	23	8.70e-01	1.97e-02	9.77e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	30	8.71e-01	-1.72e-02	9.77e-01
REACTOME FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	17	8.72e-01	-2.26e-02	9.78e-01
REACTOME ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS	5	8.74e-01	-4.09e-02	9.80e-01
REACTOME GLUCONEOGENESIS	33	8.76e-01	-1.58e-02	9.80e-01
REACTOME SCAVENGING BY CLASS F RECEPTORS	6	8.76e-01	-3.66e-02	9.80e-01
REACTOME SIGNALING BY NOTCH1	69	8.77e-01	-1.08e-02	9.80e-01
REACTOME IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN	5	8.78e-01	3.97e-02	9.80e-01
REACTOME RUNX3 REGULATES CDKN1A TRANSCRIPTION	7	8.78e-01	-3.34e-02	9.80e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	8.78e-01	-1.67e-02	9.80e-01
REACTOME GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	35	8.78e-01	-1.50e-02	9.80e-01
REACTOME PREVENTION OF PHAGOSOMAL LYSOSOMAL FUSION	9	8.79e-01	2.93e-02	9.80e-01
REACTOME PHOSPHORYLATION OF THE APC C	20	8.80e-01	1.94e-02	9.81e-01
REACTOME LOSS OF FUNCTION OF SMAD2 3 IN CANCER	7	8.81e-01	-3.26e-02	9.81e-01
REACTOME ALPHA DEFENSINS	6	8.85e-01	-3.42e-02	9.83e-01
REACTOME COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	32	8.85e-01	1.48e-02	9.83e-01
REACTOME GP1B IX V ACTIVATION SIGNALLING	11	8.86e-01	2.50e-02	9.83e-01
REACTOME NGF INDEPENDANT TRKA ACTIVATION	5	8.87e-01	-3.65e-02	9.83e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	8.88e-01	-2.04e-02	9.83e-01
REACTOME INTERLEUKIN 21 SIGNALING	9	8.88e-01	2.71e-02	9.83e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	43	8.89e-01	1.23e-02	9.83e-01
REACTOME FATTY ACID METABOLISM	170	8.89e-01	6.21e-03	9.83e-01
REACTOME COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	52	8.89e-01	-1.12e-02	9.83e-01
REACTOME FCERI MEDIATED CA 2 MOBILIZATION	30	8.89e-01	-1.47e-02	9.83e-01
REACTOME SEROTONIN RECEPTORS	11	8.90e-01	-2.40e-02	9.84e-01
REACTOME SUMOYLATION OF IMMUNE RESPONSE PROTEINS	10	8.91e-01	2.51e-02	9.84e-01
REACTOME RHOU GTPASE CYCLE	37	8.92e-01	-1.29e-02	9.84e-01
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	12	8.92e-01	-2.26e-02	9.84e-01
REACTOME ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	8.93e-01	-2.01e-02	9.84e-01
REACTOME MELANIN BIOSYNTHESIS	5	8.95e-01	3.40e-02	9.85e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	8.95e-01	1.55e-02	9.85e-01
REACTOME TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION	12	8.96e-01	-2.17e-02	9.85e-01
REACTOME G ALPHA S SIGNALLING EVENTS	155	8.97e-01	6.05e-03	9.85e-01
REACTOME REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	15	8.99e-01	1.90e-02	9.86e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION INITIATION	45	8.99e-01	1.10e-02	9.86e-01
REACTOME REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	5	8.99e-01	3.27e-02	9.86e-01
REACTOME NEGATIVE REGULATION OF MET ACTIVITY	20	9.00e-01	1.62e-02	9.86e-01
REACTOME SYNTHESIS OF KETONE BODIES	8	9.01e-01	-2.54e-02	9.86e-01
REACTOME STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	16	9.02e-01	1.78e-02	9.86e-01
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	13	9.02e-01	1.97e-02	9.86e-01
REACTOME REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	11	9.02e-01	-2.13e-02	9.86e-01
REACTOME SIGNALING BY MET	78	9.03e-01	-8.00e-03	9.86e-01
REACTOME PHASE 1 INACTIVATION OF FAST NA CHANNELS	6	9.03e-01	2.87e-02	9.86e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT	58	9.05e-01	-9.06e-03	9.87e-01
REACTOME SIGNALING BY CSF3 G CSF	30	9.05e-01	1.26e-02	9.87e-01
REACTOME TELOMERE EXTENSION BY TELOMERASE	22	9.06e-01	1.45e-02	9.87e-01
REACTOME PHOSPHOLIPID METABOLISM	201	9.07e-01	-4.77e-03	9.88e-01
REACTOME JOSEPHIN DOMAIN DUBS	11	9.08e-01	-2.02e-02	9.88e-01
REACTOME LYSINE CATABOLISM	12	9.09e-01	-1.92e-02	9.88e-01
REACTOME HIV ELONGATION ARREST AND RECOVERY	33	9.10e-01	-1.13e-02	9.88e-01
REACTOME DRUG MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY	5	9.10e-01	2.91e-02	9.88e-01
REACTOME NECTIN NECL TRANS HETERODIMERIZATION	7	9.12e-01	2.42e-02	9.88e-01
REACTOME SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	9.12e-01	-1.50e-02	9.88e-01
REACTOME DISEASES OF IMMUNE SYSTEM	29	9.12e-01	1.18e-02	9.88e-01
REACTOME INSULIN PROCESSING	24	9.13e-01	-1.29e-02	9.88e-01
REACTOME STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING	9	9.15e-01	-2.06e-02	9.90e-01
REACTOME SIALIC ACID METABOLISM	33	9.16e-01	1.06e-02	9.90e-01
REACTOME FREE FATTY ACID RECEPTORS	5	9.17e-01	-2.70e-02	9.90e-01
REACTOME NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES	7	9.17e-01	-2.27e-02	9.90e-01
REACTOME SIGNALING BY BMP	27	9.17e-01	-1.15e-02	9.90e-01
REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	21	9.18e-01	1.29e-02	9.90e-01
REACTOME CDC42 GTPASE CYCLE	144	9.19e-01	-4.89e-03	9.90e-01
REACTOME VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	42	9.20e-01	-8.96e-03	9.90e-01
REACTOME PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	9.20e-01	1.33e-02	9.90e-01
REACTOME ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	9.21e-01	-1.82e-02	9.90e-01
REACTOME SIGNALING BY FGFR4	40	9.21e-01	9.10e-03	9.90e-01
REACTOME RHOC GTPASE CYCLE	71	9.22e-01	-6.69e-03	9.90e-01
REACTOME HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS	9	9.24e-01	-1.84e-02	9.90e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	26	9.24e-01	1.08e-02	9.90e-01
REACTOME EPHRIN SIGNALING	17	9.24e-01	1.34e-02	9.90e-01
REACTOME MITOCHONDRIAL BIOGENESIS	87	9.25e-01	-5.86e-03	9.90e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	28	9.27e-01	1.01e-02	9.90e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	24	9.27e-01	-1.07e-02	9.90e-01
REACTOME RHOBTB3 ATPASE CYCLE	8	9.28e-01	1.85e-02	9.90e-01
REACTOME INTERLEUKIN 10 SIGNALING	43	9.29e-01	7.90e-03	9.90e-01
REACTOME RET SIGNALING	40	9.29e-01	8.17e-03	9.90e-01
REACTOME PHOSPHORYLATION OF EMI1	6	9.30e-01	-2.07e-02	9.90e-01
REACTOME COLLAGEN CHAIN TRIMERIZATION	42	9.30e-01	7.79e-03	9.90e-01
REACTOME HSF1 ACTIVATION	29	9.30e-01	9.37e-03	9.90e-01
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	14	9.31e-01	1.34e-02	9.90e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING	6	9.32e-01	2.01e-02	9.90e-01
REACTOME METHYLATION	14	9.33e-01	-1.31e-02	9.90e-01
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	9	9.33e-01	-1.62e-02	9.90e-01
REACTOME DISSOLUTION OF FIBRIN CLOT	13	9.33e-01	-1.34e-02	9.90e-01
REACTOME METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	122	9.33e-01	-4.38e-03	9.90e-01
REACTOME CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	63	9.34e-01	-6.04e-03	9.90e-01
REACTOME DEFECTIVE RIPK1 MEDIATED REGULATED NECROSIS	7	9.34e-01	1.80e-02	9.90e-01
REACTOME INTERLEUKIN 2 SIGNALING	11	9.34e-01	-1.44e-02	9.90e-01
REACTOME CELLULAR RESPONSE TO STARVATION	147	9.34e-01	-3.93e-03	9.90e-01
REACTOME SARS COV 2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS	12	9.37e-01	-1.32e-02	9.91e-01
REACTOME SARS COV 2 TARGETS PDZ PROTEINS IN CELL CELL JUNCTION	5	9.38e-01	-2.00e-02	9.91e-01
REACTOME REGULATION OF FZD BY UBIQUITINATION	21	9.39e-01	-9.63e-03	9.91e-01
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	9.40e-01	1.12e-02	9.91e-01
REACTOME PHENYLALANINE METABOLISM	6	9.40e-01	-1.76e-02	9.91e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	19	9.40e-01	9.91e-03	9.91e-01
REACTOME DEFECTIVE F9 ACTIVATION	5	9.41e-01	-1.92e-02	9.91e-01
REACTOME XENOBIOTICS	22	9.41e-01	-9.13e-03	9.91e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	34	9.41e-01	-7.27e-03	9.91e-01
REACTOME REGULATED PROTEOLYSIS OF P75NTR	11	9.43e-01	-1.25e-02	9.91e-01
REACTOME RHOV GTPASE CYCLE	36	9.43e-01	-6.90e-03	9.91e-01
REACTOME BIOLOGICAL OXIDATIONS	210	9.43e-01	2.86e-03	9.91e-01
REACTOME ACTIVATION OF SMO	18	9.43e-01	-9.67e-03	9.91e-01
REACTOME ACYL CHAIN REMODELLING OF PS	22	9.45e-01	-8.46e-03	9.92e-01
REACTOME CHOLESTEROL BIOSYNTHESIS	25	9.46e-01	-7.83e-03	9.93e-01
REACTOME SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	9.50e-01	9.40e-03	9.93e-01
REACTOME SYNTHESIS OF DOLICHYL PHOSPHATE	6	9.50e-01	-1.48e-02	9.93e-01
REACTOME EGFR INTERACTS WITH PHOSPHOLIPASE C GAMMA	9	9.50e-01	1.20e-02	9.93e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	9.52e-01	9.39e-03	9.93e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	16	9.52e-01	8.77e-03	9.93e-01
REACTOME PEROXISOMAL PROTEIN IMPORT	62	9.52e-01	-4.39e-03	9.93e-01
REACTOME RAF INDEPENDENT MAPK1 3 ACTIVATION	22	9.53e-01	-7.27e-03	9.93e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	93	9.53e-01	3.52e-03	9.93e-01
REACTOME TRANSLESION SYNTHESIS BY POLK	17	9.54e-01	8.11e-03	9.93e-01
REACTOME SIGNALING BY FGFR1	49	9.55e-01	-4.67e-03	9.93e-01
REACTOME PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	9.55e-01	-7.10e-03	9.93e-01
REACTOME THE PHOTOTRANSDUCTION CASCADE	32	9.55e-01	-5.71e-03	9.93e-01
REACTOME REGULATION OF BACH1 ACTIVITY	11	9.56e-01	-9.60e-03	9.93e-01
REACTOME TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	55	9.57e-01	-4.20e-03	9.93e-01
REACTOME MINERALOCORTICOID BIOSYNTHESIS	6	9.57e-01	1.27e-02	9.93e-01
REACTOME SIGNALING BY BRAF AND RAF1 FUSIONS	63	9.57e-01	-3.89e-03	9.93e-01
REACTOME RHO GTPASES ACTIVATE ROCKS	19	9.58e-01	7.06e-03	9.93e-01
REACTOME FCGR3A MEDIATED IL10 SYNTHESIS	36	9.58e-01	-5.08e-03	9.93e-01
REACTOME SIGNALING BY FGFR3	39	9.59e-01	-4.80e-03	9.93e-01
REACTOME RESOLUTION OF ABASIC SITES AP SITES	38	9.59e-01	-4.86e-03	9.93e-01
REACTOME RHO GTPASES ACTIVATE NADPH OXIDASES	21	9.60e-01	-6.33e-03	9.93e-01
REACTOME GERM LAYER FORMATION AT GASTRULATION	17	9.61e-01	-6.91e-03	9.93e-01
REACTOME DEFECTIVE EXT2 CAUSES EXOSTOSES 2	12	9.61e-01	8.21e-03	9.93e-01
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	22	9.61e-01	-6.02e-03	9.93e-01
REACTOME POLO LIKE KINASE MEDIATED EVENTS	16	9.66e-01	-6.08e-03	9.98e-01
REACTOME TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	17	9.68e-01	5.70e-03	9.99e-01
REACTOME P75NTR SIGNALS VIA NF KB	15	9.69e-01	5.87e-03	9.99e-01
REACTOME HIV TRANSCRIPTION ELONGATION	42	9.69e-01	3.47e-03	9.99e-01
REACTOME ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE	11	9.70e-01	-6.52e-03	9.99e-01
REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	9.71e-01	4.54e-03	9.99e-01
REACTOME MET RECEPTOR ACTIVATION	6	9.72e-01	8.33e-03	9.99e-01
REACTOME DEFECTIVE CHSY1 CAUSES TPBS	7	9.73e-01	-7.52e-03	9.99e-01
REACTOME ANDROGEN BIOSYNTHESIS	11	9.73e-01	-5.92e-03	9.99e-01
REACTOME O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	38	9.74e-01	-3.01e-03	9.99e-01
REACTOME TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	16	9.75e-01	4.60e-03	9.99e-01
REACTOME SUPPRESSION OF PHAGOSOMAL MATURATION	13	9.75e-01	4.96e-03	9.99e-01
REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	9.77e-01	-4.71e-03	9.99e-01
REACTOME BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA	5	9.77e-01	-7.54e-03	9.99e-01
REACTOME METABOLISM OF NUCLEOTIDES	94	9.77e-01	1.72e-03	9.99e-01
REACTOME HUR ELAVL1 BINDS AND STABILIZES MRNA	8	9.77e-01	-5.88e-03	9.99e-01
REACTOME METABOLISM OF FOLATE AND PTERINES	17	9.77e-01	4.00e-03	9.99e-01
REACTOME ARMS MEDIATED ACTIVATION	7	9.79e-01	-5.78e-03	1.00e+00
REACTOME EPHB MEDIATED FORWARD SIGNALING	41	9.80e-01	-2.26e-03	1.00e+00
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	27	9.82e-01	2.54e-03	1.00e+00
REACTOME EUKARYOTIC TRANSLATION ELONGATION	87	9.82e-01	1.37e-03	1.00e+00
REACTOME ACTIVATION OF TRKA RECEPTORS	6	9.83e-01	-5.08e-03	1.00e+00
REACTOME SUMO IS CONJUGATED TO E1 UBA2 SAE1	5	9.83e-01	-5.44e-03	1.00e+00
REACTOME ONCOGENIC MAPK SIGNALING	79	9.84e-01	-1.32e-03	1.00e+00
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	123	9.84e-01	-1.03e-03	1.00e+00
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	11	9.84e-01	3.41e-03	1.00e+00
REACTOME GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	34	9.85e-01	-1.92e-03	1.00e+00
REACTOME VITAMIN B2 RIBOFLAVIN METABOLISM	7	9.86e-01	-3.81e-03	1.00e+00
REACTOME SODIUM COUPLED SULPHATE DI AND TRI CARBOXYLATE TRANSPORTERS	5	9.87e-01	-4.15e-03	1.00e+00
REACTOME PARASITE INFECTION	57	9.89e-01	-1.05e-03	1.00e+00
REACTOME PP2A MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS	6	9.89e-01	-3.20e-03	1.00e+00
REACTOME DEVELOPMENTAL BIOLOGY	1115	9.89e-01	-2.39e-04	1.00e+00
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	15	9.89e-01	-1.97e-03	1.00e+00
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	12	9.90e-01	-2.11e-03	1.00e+00
REACTOME BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	19	9.91e-01	-1.55e-03	1.00e+00
REACTOME NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	19	9.91e-01	-1.47e-03	1.00e+00
REACTOME CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	25	9.91e-01	-1.28e-03	1.00e+00
REACTOME PROCESSING AND ACTIVATION OF SUMO	10	9.93e-01	1.57e-03	1.00e+00
REACTOME REDUCTION OF CYTOSOLIC CA LEVELS	11	9.93e-01	1.47e-03	1.00e+00
REACTOME RESPONSE TO METAL IONS	14	9.93e-01	1.27e-03	1.00e+00
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	16	9.95e-01	-9.66e-04	1.00e+00
REACTOME METABOLISM OF STEROIDS	150	9.95e-01	3.03e-04	1.00e+00
REACTOME TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	20	9.95e-01	-7.96e-04	1.00e+00
REACTOME ANCHORING FIBRIL FORMATION	13	9.96e-01	-7.97e-04	1.00e+00
REACTOME ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	20	9.96e-01	-6.37e-04	1.00e+00
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	105	9.97e-01	2.35e-04	1.00e+00
REACTOME ERYTHROPOIETIN ACTIVATES STAT5	7	9.97e-01	8.96e-04	1.00e+00
REACTOME MAPK3 ERK1 ACTIVATION	10	9.97e-01	-7.36e-04	1.00e+00
REACTOME FOXO MEDIATED TRANSCRIPTION	65	9.97e-01	-2.54e-04	1.00e+00
REACTOME SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	31	9.99e-01	-1.82e-04	1.00e+00
REACTOME ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	59	9.99e-01	-8.65e-05	1.00e+00
REACTOME METABOLISM OF PORPHYRINS	26	1.00e+00	3.50e-05	1.00e+00
REACTOME BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA	6	1.00e+00	-4.55e-05	1.00e+00

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Detailed Gene set reports

REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

	1161
set	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION
setSize	1336
pANOVA	8.52e-11
s.dist	-0.106
p.adjustANOVA	1.4e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ZNF676	-11231
ZIM2	-11171
ZNF383	-11161
THOC3	-11116
ZNF732	-11101
GP1BA	-11099
ZNF445	-11074
CTSL	-11021
MIR24-2	-10989
ZNF738	-10970
MIR27A	-10966
ZNF208	-10947
UBE2S	-10880
ZNF468	-10874
ZNF562	-10857
CCNG1	-10833
POU4F1	-10825
H2BC13	-10817
ZNF443	-10814
GATA3	-10779

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ZNF676	-11231.0
ZIM2	-11171.0
ZNF383	-11161.0
THOC3	-11116.0
ZNF732	-11101.0
GP1BA	-11099.0
ZNF445	-11074.0
CTSL	-11021.0
MIR24-2	-10989.0
ZNF738	-10970.0
MIR27A	-10966.0
ZNF208	-10947.0
UBE2S	-10880.0
ZNF468	-10874.0
ZNF562	-10857.0
CCNG1	-10833.0
POU4F1	-10825.0
H2BC13	-10817.0
ZNF443	-10814.0
GATA3	-10779.0
ZNF613	-10763.0
TNFRSF10C	-10746.0
H2BC10	-10719.0
PIP4K2C	-10714.0
NKX3-2	-10709.0
ZNF19	-10667.0
ZNF627	-10665.0
H2AC7	-10629.5
H2BC7	-10629.5
BMP2	-10624.0
ZNF792	-10616.0
H3C12	-10612.0
IL2	-10597.0
ZNF625	-10588.0
ZNF331	-10571.0
H3C8	-10552.0
CSF2	-10550.0
ZNF224	-10472.0
ZNF660	-10422.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
RHNO1	-10392.0
RNU4ATAC	-10375.0
E2F1	-10358.0
ZNF124	-10341.0
PGR	-10303.0
RB1	-10297.0
ZNF607	-10246.0
ZNF776	-10240.0
ZNF669	-10238.0
ZNF679	-10222.0
ZNF416	-10215.0
ZNF667	-10162.0
ZNF431	-10155.0
YWHAB	-10128.0
VEGFA	-10112.0
ZNF429	-10111.0
SERPINE1	-10104.0
PCBP4	-10096.0
H3C4	-10062.0
ZFP2	-10037.0
ZNF484	-10007.0
ZNF71	-9992.0
ZNF74	-9985.0
INTS14	-9947.0
COX5B	-9937.0
ZNF20	-9931.0
TOP3A	-9928.0
ZNF804B	-9907.0
ZNF30	-9897.0
H4C9	-9887.0
ZNF112	-9858.0
SOCS3	-9851.0
H4C12	-9845.0
ZNF761	-9842.0
ZNF273	-9813.0
TFDP1	-9800.0
MAF	-9790.0
KMT2C	-9762.0
AIFM2	-9750.0
INTS7	-9738.0
CBX8	-9733.0
PIP4K2B	-9724.0
PSMD8	-9717.0
AGRP	-9693.0
ZNF197	-9680.0
H2AC8	-9679.0
PSMC6	-9675.0
ZNF671	-9669.0
NR4A3	-9622.0
ZNF585A	-9614.0
CBX4	-9601.0
ZNF614	-9593.0
H2BC8	-9584.0
CCNE2	-9570.0
ZNF681	-9565.0
SRSF9	-9561.0
TXNIP	-9525.0
ZNF554	-9522.0
ZC3H11A	-9520.0
H2BC17	-9503.0
SNRPB	-9483.0
H3C10	-9467.0
PSMD14	-9466.0
KRBOX5	-9448.0
UBE2C	-9436.0
FBXO32	-9426.0
IL3	-9418.0
ZNF222	-9382.0
H2BC9	-9375.5
H3C7	-9375.5
ZNF302	-9366.0
CTDP1	-9365.0
TFAP2C	-9345.0
H2AC4	-9326.0
MAML1	-9302.0
ZNF550	-9300.0
ZNF471	-9278.0
YWHAQ	-9275.0
ZNF333	-9274.0
ZNF426	-9271.0
ZNF268	-9270.0
SKIL	-9267.0
CASP10	-9252.0
CTR9	-9231.0
PSMC3	-9217.0
ZNF225	-9215.0
PARP1	-9214.0
ZNF337	-9189.0
PRKAG1	-9183.0
NRBF2	-9175.0
XPO1	-9161.0
ZNF334	-9145.0
FOXG1	-9135.0
ZNF350	-9131.0
BCL2L14	-9122.0
EAF1	-9118.0
ZNF200	-9108.0
RBL1	-9102.0
BRCA1	-9099.0
CDKN2B	-9096.0
PSMA7	-9072.0
TXN	-9040.0
NPM1	-9022.0
H3C11	-9013.0
GTF2F1	-8995.0
ZNF543	-8991.0
NR1I3	-8974.0
TFAP2A	-8963.0
PRDX1	-8962.0
PRDM1	-8935.0
MAPKAPK5	-8927.0
ZNF699	-8899.0
ZNF737	-8894.0
BIRC5	-8888.0
PSMD9	-8887.0
EAF2	-8865.0
RAD51D	-8859.0
ZNF460	-8851.0
ZNF223	-8842.0
NR1H2	-8827.0
ZNF184	-8814.0
HDAC9	-8812.0
YY1	-8801.0
PSMA6	-8781.0
MED6	-8775.0
GTF2A1	-8765.0
PSMB10	-8751.0
ZNF793	-8746.0
CASP6	-8718.0
PRKACA	-8712.0
ZNF45	-8708.0
RSPO3	-8699.0
MRE11	-8696.0
MSTN	-8691.0
ZNF749	-8647.0
JAG1	-8645.0
H2BC15	-8620.0
ZNF696	-8595.0
SATB2	-8577.0
TRIM28	-8574.0
ZKSCAN3	-8547.0
PIP4P1	-8531.0
PSMC2	-8506.0
RBBP5	-8494.0
ZNF706	-8469.0
ZNF500	-8461.0
ZNF347	-8425.0
RFC5	-8423.0
ZC3H8	-8415.0
KLF4	-8412.0
TAF3	-8410.0
ZNF678	-8346.0
NR2E1	-8344.0
ZNF544	-8323.0
PSMB11	-8322.0
ZNF17	-8306.0
H2AX	-8295.0
H3-3B	-8282.0
ZNF99	-8274.0
NPPA	-8260.0
TTC5	-8250.0
ZFP28	-8228.0
ZNF248	-8197.0
ZNF510	-8165.0
ZNF670	-8107.0
CPSF6	-8104.0
FANCC	-8101.0
GTF2A2	-8087.0
CDKN2A	-8076.0
HES1	-8063.0
CPSF2	-8062.0
SESN2	-8041.0
ZNF750	-8030.0
TWIST1	-7975.0
ZNF546	-7959.0
TAF11	-7947.0
MSX2	-7943.0
ZNF790	-7941.0
H4C13	-7923.0
H3C6	-7918.0
ZNF778	-7910.0
TCF12	-7906.0
ZNF703	-7900.0
CDC7	-7868.0
PSMF1	-7828.0
ZNF551	-7820.0
ZNF785	-7801.0
NR2E3	-7800.0
ERCC3	-7795.0
TAF13	-7780.0
TAL1	-7764.0
ZNF619	-7742.0
CSNK2A2	-7701.0
RBBP8	-7671.0
ZNF493	-7660.0
COX19	-7657.0
ITGA4	-7639.0
NR6A1	-7636.0
PITX2	-7618.0
PSMB3	-7613.0
MAPK3	-7607.0
NKX2-5	-7602.0
SOX9	-7596.0
PRMT5	-7574.0
PRDX2	-7551.0
THOC1	-7547.0
CDK4	-7529.0
ATM	-7508.0
ZNF33B	-7476.0
ZNF286A	-7475.0
CASP2	-7460.0
ATRIP	-7443.0
BGLAP	-7441.0
ZNF221	-7431.0
ALYREF	-7406.0
ICE2	-7393.0
SGK1	-7370.0
TACO1	-7368.0
ZNF700	-7363.0
CSTF3	-7348.0
TOPBP1	-7343.0
ZNF343	-7316.0
ZNF777	-7301.0
ZNF26	-7271.0
CASC3	-7261.0
PMS2	-7243.0
SETD1A	-7232.0
ZNF519	-7231.0
FIP1L1	-7227.0
INTS10	-7213.0
RPTOR	-7125.0
NR3C2	-7120.0
KRAS	-7071.0
LBR	-7065.0
CCNE1	-7048.0
ZNF425	-7024.0
SESN3	-7021.0
SNAPC3	-6977.0
ZNF718	-6973.0
RNF34	-6956.0
PSMA4	-6953.0
ZNF385A	-6942.0
ERBB2	-6935.0
YES1	-6925.0
ZNF43	-6909.0
SKP1	-6898.0
GAD1	-6890.0
ZNF548	-6867.0
ZNF92	-6833.0
ZNF682	-6826.0
NR2C2	-6822.0
ZNF595	-6818.0
ZNF764	-6803.0
HAND2	-6802.0
EZH2	-6787.0
SRSF6	-6777.0
MDM2	-6733.0
PSMB8	-6727.0
ZNF485	-6725.0
ZNF234	-6687.0
ZNF263	-6647.0
CNOT2	-6646.0
FOS	-6639.0
ZNF587	-6637.0
CCNT2	-6619.0
MLH1	-6596.0
OPRK1	-6593.0
MBD3	-6559.0
CCNC	-6540.0
PRKAB2	-6537.0
RABGGTB	-6522.0
ZFP69	-6500.0
ZNF253	-6481.0
ZNF418	-6460.0
PSMB1	-6458.0
INTS4	-6440.0
SIRT3	-6421.0
INTS9	-6415.0
COX14	-6412.0
TGFB1	-6399.0
YEATS4	-6394.0
NR5A2	-6389.0
RFC4	-6357.0
CNOT1	-6330.0
PPP2R1B	-6311.0
TAF2	-6310.0
ZNF496	-6303.0
PTPN11	-6297.0
PRDM7	-6268.0
CDK7	-6225.0
NOTCH3	-6204.0
KCTD6	-6190.0
ANAPC5	-6173.0
RAD51	-6165.0
ZNF549	-6156.0
POLR2G	-6150.0
HNF4G	-6141.0
INTS12	-6137.0
MAGOHB	-6119.0
COX6A1	-6078.0
ZNF420	-6075.0
CHTOP	-6070.0
ZNF555	-6066.0
RBL2	-6043.0
COX7C	-6031.0
ZNF77	-6029.0
ZNF585B	-6008.0
ZNF454	-5995.0
H4C8	-5994.0
CDC73	-5992.0
H2BC26	-5963.0
SUPT16H	-5961.0
H2BC6	-5953.0
ZNF775	-5952.0
H4C1	-5951.0
ZNF774	-5947.0
ZNF724	-5941.0
YWHAH	-5939.0
RPS27A	-5922.0
ASH2L	-5916.0
NFYA	-5900.0
ZNF446	-5859.0
ZNF135	-5853.0
ITGAL	-5847.0
ZNF697	-5836.0
AUTS2	-5833.0
CENPJ	-5832.0
CCN2	-5822.0
ZNF561	-5801.0
CBX3	-5783.0
H2AZ2	-5775.0
RING1	-5768.0
H2BC11	-5756.0
TAF1L	-5747.0
GPI	-5741.0
ZNF300	-5739.0
ZNF138	-5736.0
ELOC	-5705.0
BCL6	-5704.0
ZNF616	-5640.0
DLL1	-5616.0
ZNF3	-5615.0
ZNF433	-5611.0
SNRPG	-5578.0
ZFP30	-5577.0
KMT2D	-5563.0
ING5	-5548.0
CCNT1	-5531.0
SOD2	-5530.0
ZNF114	-5502.0
PCK1	-5499.0
CPSF7	-5495.0
HDAC4	-5485.0
ARID2	-5478.0
TNRC6B	-5455.0
PSMD4	-5443.0
ZNF441	-5424.0
RNF111	-5415.0
ZNF304	-5411.0
FASLG	-5399.0
ZNF530	-5396.0
SMARCD3	-5384.0
PTPN4	-5375.0
ZNF582	-5365.0
CHEK1	-5363.0
PSMB5	-5303.0
TSC1	-5300.0
CSNK2B	-5291.0
SMAD1	-5284.0
WWP1	-5282.0
LGALS3	-5279.0
UBB	-5278.0
GTF2B	-5265.0
TRIM33	-5210.0
GPAM	-5201.0
ZNF12	-5199.0
PPM1A	-5167.0
ZNF213	-5154.0
CCNB1	-5146.0
MED20	-5139.0
ZNF605	-5122.0
INTS13	-5112.0
LDB1	-5103.0
NCOR1	-5091.0
RNMT	-5078.0
MMP13	-5052.0
BDNF	-5050.0
PSMA3	-5040.0
SLC2A3	-5029.0
ZNF615	-5018.0
ZNF620	-4996.0
E2F8	-4985.0
TAF4	-4973.0
RHEB	-4959.0
MLLT1	-4947.0
RORB	-4941.0
SMAD2	-4901.0
H3C2	-4876.0
RBM14	-4862.0
RUNX1	-4859.0
ELF2	-4857.0
KAT2B	-4853.0
TCF3	-4833.0
POLR2H	-4815.0
GTF2H5	-4812.0
POLDIP3	-4797.0
ZSCAN32	-4787.0
CALM1	-4778.0
ZNF473	-4764.0
PMAIP1	-4756.0
INTS8	-4753.0
IFNG	-4723.0
VDR	-4717.0
PRKCQ	-4715.0
CNOT10	-4711.0
ZNF714	-4671.0
ZNF704	-4668.0
ZNF677	-4664.0
CNOT6L	-4649.0
SP1	-4636.0
ZNF610	-4625.0
PPARGC1A	-4617.0
CGA	-4601.0
NBN	-4575.0
MAGOH	-4562.0
ZNF266	-4554.0
GRIA2	-4518.0
ZNF684	-4506.0
ATR	-4504.0
SCMH1	-4488.0
MYB	-4476.0
GLS	-4464.0
ZNF540	-4452.0
RPRD2	-4445.0
ZNF624	-4439.0
PERP	-4437.0
MNAT1	-4434.0
CEBPB	-4430.0
HSPD1	-4382.0
SIN3B	-4370.0
PVALB	-4355.0
ZIK1	-4331.0
ZNF470	-4327.0
PHC3	-4300.0
ZNF480	-4288.0
GATA4	-4277.0
PPP2R1A	-4275.0
SMAD6	-4240.0
AFF4	-4212.0
BBC3	-4194.0
CYCS	-4191.0
ZNF708	-4173.0
ZNF354A	-4171.0
ZNF483	-4146.0
TGFA	-4134.0
SRSF2	-4120.0
NR2C2AP	-4072.0
POLR2L	-4064.0
GSK3B	-4058.0
MOV10	-4030.0
MED30	-4026.0
CCNA1	-4010.0
ACTL6A	-4005.0
GTF2F2	-4002.0
SUPT4H1	-4001.0
ZNF521	-3997.0
SRSF4	-3993.0
FOXO1	-3987.0
BARD1	-3957.0
TCF7	-3950.0
TP53	-3947.0
MEF2C	-3937.0
PRDX5	-3932.0
ZKSCAN7	-3915.0
NELFE	-3914.0
COL1A2	-3910.0
COX6B1	-3896.0
ZNF354C	-3831.0
ZNF264	-3817.0
SRSF3	-3801.0
TEAD2	-3774.0
ZNF621	-3762.0
ZNF713	-3738.0
ZNF746	-3712.0
ZNF233	-3662.0
SARNP	-3648.0
NFKB1	-3646.0
PRMT1	-3642.0
ZNF436	-3615.0
TFAP2B	-3614.0
CBX2	-3609.0
BLM	-3594.0
PPM1D	-3590.0
PLK2	-3578.0
THOC5	-3569.0
RMI2	-3522.0
TAF4B	-3511.0
FURIN	-3491.0
BRIP1	-3490.0
MEAF6	-3483.0
ZNF10	-3478.0
NR2C1	-3476.0
TFAP2D	-3473.0
TNRC6A	-3455.0
WRN	-3454.0
MED15	-3427.0
ZNF394	-3404.0
LAMTOR5	-3379.0
RBPJ	-3370.0
ZNF2	-3365.0
MED1	-3348.0
BRD1	-3347.0
ZNF28	-3333.0
PCGF6	-3316.0
TFDP2	-3304.0
KDM5B	-3294.0
ZNF257	-3275.0
RNGTT	-3274.0
SMAD3	-3269.0
WDR5	-3255.0
HDAC1	-3246.0
FAS	-3226.0
PSMB7	-3196.0
TGIF1	-3183.0
ZNF34	-3182.0
ZNF440	-3170.0
DLX6	-3168.0
ZFHX3	-3148.0
WWTR1	-3118.0
ZNF33A	-3106.0
RBBP4	-3061.0
MAPK14	-3056.0
ANAPC10	-3050.0
BLK	-3048.0
PSMA1	-3041.0
SESN1	-3034.0
POLR2I	-2974.0
H4C4	-2969.0
RAD17	-2958.0
PIN1	-2937.0
ZNF100	-2911.0
TPX2	-2887.0
ZNF254	-2878.0
ESRRB	-2843.0
MAX	-2796.0
ZNF398	-2782.0
USP2	-2777.0
TBX5	-2776.0
ZNF180	-2767.0
PCGF5	-2747.0
HEY1	-2737.0
SCO1	-2736.0
NOTCH1	-2718.0
HNF4A	-2713.0
ZNF786	-2702.0
YAF2	-2696.0
PPARA	-2694.0
SOX2	-2653.0
DEK	-2635.0
ZNF589	-2601.0
PSMC5	-2598.0
RICTOR	-2592.0
PSMD7	-2547.0
INTS2	-2542.0
ZNF729	-2539.0
H4C11	-2506.0
PBRM1	-2503.0
ANAPC11	-2468.0
DLX5	-2466.0
LEO1	-2458.0
MDC1	-2451.0
ZNF235	-2442.0
ZNF285	-2429.0
RET	-2407.0
APAF1	-2405.0
ZNF571	-2391.0
PDPK1	-2363.0
CNOT4	-2357.0
LRPPRC	-2344.0
CNOT7	-2342.0
DPY30	-2335.0
CDC40	-2333.0
ZNF37A	-2332.0
OCLN	-2331.0
SRSF11	-2320.0
HEY2	-2313.0
FBXW7	-2293.0
ZNF324B	-2288.0
LMO2	-2271.0
UBE2D1	-2260.0
MED10	-2239.0
ZNF211	-2216.0
ING2	-2211.0
CSF1R	-2210.0
ZNF490	-2174.0
H2BC4	-2161.0
ZNF25	-2154.0
EHMT2	-2146.0
ELL3	-2141.0
RXRA	-2115.0
YWHAZ	-2100.0
ZNF558	-2094.0
AGO2	-2087.0
UBC	-2067.0
H2AC6	-2051.0
RETN	-2045.0
DDB2	-2043.0
ZNF771	-2037.0
ZNF773	-2012.0
NR2F1	-2007.0
NCBP2	-1986.0
IHH	-1982.0
MET	-1981.0
TSC2	-1976.0
ZNF735	-1942.0
SMARCE1	-1928.0
RFC3	-1900.0
ITCH	-1877.0
RMI1	-1872.0
CSNK2A1	-1846.0
PPP2R5C	-1840.0
RORA	-1838.0
NEDD4L	-1832.0
CNOT8	-1830.0
ANAPC4	-1807.0
ZNF439	-1795.0
ZNF250	-1779.0
TAF9	-1757.0
ZNF267	-1750.0
ZNF517	-1724.0
COX4I1	-1719.0
ZNF596	-1711.0
ZNF215	-1709.0
PRKCB	-1707.0
NFYB	-1691.0
SRSF5	-1688.0
ZNF227	-1674.0
POU2F1	-1664.0
PLAGL1	-1645.0
NR1H3	-1624.0
ESR2	-1612.0
ZNF324	-1610.0
PRKAA1	-1598.0
ZNF584	-1577.0
SLC38A9	-1568.0
IL2RA	-1554.0
IGFBP3	-1539.0
ZNF140	-1533.0
RBFOX1	-1511.0
CSTF2T	-1503.0
PTEN	-1491.0
CRADD	-1481.0
RXRB	-1460.0
TBL1XR1	-1458.0
EP300	-1428.0
H4C5	-1423.0
CARM1	-1419.0
NAMPT	-1389.0
U2AF1L4	-1363.0
CNOT6	-1349.0
MEN1	-1348.0
H3-3A	-1342.0
SIN3A	-1299.0
RRAGA	-1253.0
ZNF568	-1244.0
HUS1	-1217.0
SPI1	-1209.0
MED13	-1201.0
DNA2	-1169.0
POLR2F	-1161.0
SLBP	-1160.0
NDUFA4	-1155.0
CCNH	-1145.0
SETD9	-1136.0
SOCS4	-1119.0
GSR	-1116.0
JUNB	-1099.0
PSMB6	-1085.0
SYT10	-1083.0
NR4A2	-1052.0
ZNF317	-1037.0
WWOX	-1034.0
ZFP69B	-1024.0
H2BC5	-999.0
THBS1	-977.0
PSMA5	-964.0
PSMB4	-949.0
NABP2	-895.0
COL1A1	-869.0
EED	-862.0
CCND2	-858.0
ZNF432	-820.0
MLLT3	-814.0
ZNF707	-789.0
LAMTOR1	-782.0
YWHAG	-766.0
BANP	-761.0
ICE1	-759.0
L3MBTL1	-753.0
L3MBTL2	-746.0
PSMA2	-698.0
POLR2A	-696.0
JUN	-686.0
LSM11	-660.0
TXNRD1	-647.0
EHMT1	-638.0
HIPK1	-635.0
CLP1	-624.0
MOBP	-616.0
CDC16	-598.0
CNOT3	-591.0
COX5A	-586.0
CCNK	-584.0
AXIN1	-582.0
GRIN2A	-578.0
DYRK2	-551.0
SRSF7	-534.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
ZNF655	-434.0
ZFP1	-431.0
SMARCD2	-427.0
COX11	-418.0
ZNF354B	-408.0
MAPKAP1	-395.0
WDR33	-392.0
YAP1	-378.0
PRELID1	-368.0
ITGBL1	-364.0
SNAPC4	-316.0
RPA3	-298.0
ZNF492	-294.0
MTOR	-291.0
AKT3	-289.0
UBE2D3	-275.0
RBX1	-261.0
ZNF566	-258.0
CNOT11	-218.0
SRC	-215.0
ESRRG	-209.0
GTF2H1	-188.0
ZFP14	-169.0
CDK8	-155.0
THOC6	-137.0
CDC26	-126.0
NLRC4	-117.0
ZNF506	-116.0
FOXO3	-113.0
ESR1	-109.0
NRBP1	-61.0
LEF1	-58.0
NOTCH4	-52.0
PSMD11	-47.0
CDKN1A	1.0
MAPK11	20.0
IQSEC3	31.0
MED8	40.0
BRD2	42.0
IL6	43.0
CDK9	48.0
PCNA	79.0
HIVEP3	85.0
ZNF875	96.0
GCK	102.0
SUZ12	106.0
RNPS1	109.0
ZKSCAN8	136.0
SRSF1	160.0
THRB	164.0
SKP2	169.0
HIPK2	199.0
NR3C1	227.0
ZNF564	239.0
CCNA2	268.0
ZNF160	282.0
PSME3	308.0
SKI	320.0
PRKAB1	336.0
ZNF189	344.0
NELFB	359.0
NELFA	403.0
ZNF133	404.0
H4C3	423.0
HDAC7	431.0
GADD45A	445.0
SNW1	461.0
ZNF782	466.0
ATAD2	469.0
TBP	561.0
UBE2I	584.0
GRIN2B	587.0
CTNNB1	601.0
CDK1	604.0
ZNF573	610.0
SIRT1	613.0
PSMB9	675.0
ZNF226	702.0
MAP2K6	747.0
ZNF547	780.0
CDK6	783.0
ZNF600	788.0
KCTD1	789.0
PLXNA4	800.0
SUMO1	802.0
PML	823.0
ZNF709	824.0
ANAPC7	838.0
KMT5A	861.0
PHC2	864.0
FOXO6	877.0
ZNF721	910.0
NCOR2	927.0
AGO3	957.0
COX16	964.0
SETD1B	971.0
ZNF75A	989.0
ZNF570	1025.0
ZNF169	1039.0
RAD50	1099.0
SRRT	1115.0
PSMD5	1121.0
EGFR	1128.0
NFATC2	1132.0
CAMK2G	1138.0
TP53I3	1164.0
GTF2E2	1185.0
PPARG	1193.0
CDC25C	1212.0
CNOT9	1230.0
SNAPC5	1232.0
TAF6	1262.0
NABP1	1286.0
ZNF256	1292.0
NR1D2	1313.0
H4C16	1337.0
ZNF772	1343.0
DHX38	1365.0
ZNF567	1369.0
RELA	1384.0
BMI1	1398.0
PRKAA2	1405.0
RNU12	1420.0
RPAP2	1425.0
CBFB	1427.0
SERPINB13	1436.0
REST	1451.0
ZNF282	1465.0
MYC	1474.0
PSMD12	1518.0
AGO4	1527.0
ZNF461	1542.0
ATF2	1544.0
INTS5	1548.0
PHC1	1550.0
MAPK1	1551.0
SMURF1	1566.0
PRKAG3	1580.0
ZNF143	1609.0
FANCI	1630.0
PRKAG2	1640.0
KCTD15	1643.0
ABL1	1646.0
LAMTOR2	1659.0
CDC23	1666.0
RRAGC	1685.0
ZNF668	1698.0
H2AJ	1704.0
SNRPD3	1725.0
ZNF557	1729.0
FYTTD1	1760.0
COX20	1778.0
PAPOLA	1779.0
SMYD2	1781.0
MAML2	1782.0
SSRP1	1806.0
PSMD13	1814.0
YWHAE	1817.0
BTG1	1854.0
SMARCA2	1891.0
CDK2	1892.0
HDAC3	1918.0
PPP1R13B	1925.0
CBX5	1947.0
IGFBP1	1954.0
ZFP37	1964.0
H2BC3	1965.0
PSMC4	1992.0
ZNF552	2046.0
RBM8A	2115.0
ZNF658	2139.0
KCNIP3	2141.0
JMY	2162.0
ZNF195	2177.0
GEM	2201.0
TP53AIP1	2240.0
SNAPC1	2253.0
SMARCD1	2272.0
RFC2	2285.0
MED4	2304.0
TP63	2305.0
RUNX2	2370.0
ZNF415	2374.0
H2BC21	2421.0
SMAD4	2454.0
THOC7	2458.0
SRRM1	2471.0
MED16	2484.0
PHF20	2500.0
INTS3	2522.0
ZNF565	2567.0
PSMD3	2572.0
CPSF4	2598.0
RAD1	2602.0
ZNF212	2606.0
MSH2	2623.0
ZNF606	2627.0
SKIC8	2640.0
KAT6A	2676.0
ATXN3	2681.0
PSMB2	2710.0
TNKS1BP1	2711.0
CDK13	2713.0
NR1D1	2727.0
RNF2	2733.0
ELL	2755.0
ZKSCAN5	2759.0
H2AZ1	2761.0
ANAPC2	2780.0
NFE2	2798.0
POLR2B	2810.0
TP53BP2	2833.0
RBFOX3	2842.0
ZNF839	2853.0
LIFR	2863.0
PCGF2	2874.0
TAF15	2884.0
UBA52	2905.0
CAMK2D	2908.0
HDAC10	2927.0
NR1I2	2938.0
RARA	2942.0
TJP1	2956.0
CCND1	2977.0
TAF12	2983.0
ZNF154	2988.0
SNAPC2	3023.0
MED25	3030.0
NUDT21	3088.0
ZKSCAN4	3122.0
CPSF3	3160.0
RARB	3164.0
RPRD1B	3169.0
SLU7	3203.0
HTT	3208.0
PIP4K2A	3219.0
GLS2	3220.0
POU4F2	3221.0
FKBP5	3222.0
ZNF649	3233.0
ZNF14	3296.0
RRM2	3305.0
BCL2L11	3314.0
TIGAR	3317.0
CRH	3367.0
EIF4A3	3370.0
SYMPK	3397.0
ZKSCAN1	3424.0
E2F6	3430.0
ZNF641	3434.0
RTF1	3475.0
RAD9A	3485.0
ZNF611	3495.0
MIR132	3525.0
ZNF230	3530.0
TAF5	3532.0
GAD2	3533.0
PSMC1	3545.0
EXO1	3564.0
SMURF2	3581.0
ACTL6B	3600.0
GLI3	3601.0
BAX	3602.0
CDKN1B	3615.0
CHD4	3616.0
CITED2	3626.0
GTF2E1	3630.0
NOC2L	3638.0
STAT1	3655.0
ZNF442	3674.0
AURKA	3712.0
FANCD2	3740.0
NR1H4	3746.0
CAV1	3754.0
GAMT	3772.0
PSME4	3824.0
MED23	3830.0
ZNF479	3835.0
AKT2	3850.0
GATAD2B	3897.0
E2F7	3902.0
NR5A1	3908.0
NPY	3915.0
TRIAP1	3930.0
TWIST2	3932.0
NUAK1	3956.0
ARNT2	3963.0
CITED4	3994.0
CDK5	4008.0
PABPN1	4016.0
ZNF597	4041.0
PRMT6	4052.0
ZNF419	4061.0
ZNF141	4069.0
SREBF1	4098.0
GPX2	4116.0
POLR2J	4123.0
CREBBP	4132.0
ZNF664	4157.0
BRPF3	4165.0
ZNF155	4197.0
ARID1B	4198.0
TEAD1	4218.0
GPRIN1	4287.0
SPP1	4314.0
ZNF560	4333.0
TMEM219	4340.0
TNRC6C	4348.0
ZFP90	4361.0
TCF7L2	4369.0
RXRG	4393.0
H4C2	4419.0
ELOB	4422.0
TNFRSF10D	4428.0
STEAP3	4437.0
NCBP1	4442.0
CCND3	4478.0
APOE	4484.0
PSME2	4493.0
CSTF1	4494.0
MAML3	4519.0
DGCR8	4527.0
ZNF688	4555.0
SMARCC2	4576.0
POLR2C	4579.0
FZR1	4599.0
GTF2H4	4615.0
SUPT5H	4635.0
KMT2A	4645.0
PPP2CB	4668.0
CGB5	4693.0
COX6C	4732.0
ZNF529	4746.0
TCF7L1	4753.0
ITGA5	4830.0
PAX5	4856.0
PSMA8	4885.0
H3C3	4893.0
RAD9B	4895.0
LAMTOR4	4911.0
ZNF710	4950.0
ZNF689	4955.0
POU2F2	4958.0
TRPC3	4968.0
YBX1	4979.0
SNRPF	5009.0
CHEK2	5010.0
ZNF18	5025.0
CBX6	5032.0
SSU72	5052.0
KMT2E	5064.0
ZNF528	5125.0
INTS11	5133.0
H2AC20	5150.0
ZNF70	5202.0
BRD7	5215.0
AURKB	5224.0
SURF1	5237.0
PRELID3A	5250.0
ZNF665	5288.0
GTF2H3	5292.0
MLST8	5301.0
ELL2	5323.0
CDC27	5348.0
MED17	5362.0
ZNF691	5395.0
ZNF770	5404.0
ZNF740	5439.0
SMARCA4	5513.0
ZNF599	5536.0
ZIM3	5537.0
PINK1	5544.0
ABCA6	5580.0
RABGGTA	5626.0
ZNF311	5628.0
AKT1	5667.0
ZNF175	5673.0
SST	5695.0
ELF1	5709.0
ELOA2	5752.0
ELOA	5760.0
ZNF692	5766.0
ZNF79	5770.0
NPAS4	5772.0
ANAPC1	5774.0
CAMK4	5829.0
ANAPC15	5844.0
KRBA1	5868.0
PTPN1	5875.0
BNIP3L	5884.0
GLI2	5894.0
KIT	5906.0
MED26	5932.0
TP73	5955.0
ZNF747	5986.0
H2BC14	6016.0
LMO1	6031.0
CTSV	6040.0
TNFRSF18	6070.0
PPARGC1B	6076.0
TNFRSF10A	6101.0
ZNF559	6142.0
RNU11	6149.0
HDAC2	6155.0
RPA1	6175.0
PIDD1	6180.0
EPC1	6183.0
MGA	6189.0
ZNF417	6191.0
ZNF726	6194.0
MIR137	6205.0
GATAD2A	6214.0
HDAC5	6223.0
MED31	6224.0
ANAPC16	6225.0
ZSCAN25	6235.0
ZNF430	6253.0
RPRD1A	6273.0
H2BC1	6290.0
ZNF23	6291.0
PRR5	6292.0
SMAD7	6293.0
PSME1	6314.0
CASP1	6316.0
SP7	6349.0
MED7	6389.0
RGCC	6395.0
MED27	6453.0
PPARD	6457.0
H3C1	6458.0
ZNF136	6501.0
POLR2E	6530.0
PLK3	6538.0
E2F5	6570.0
ZNF730	6571.0
CREB1	6597.0
CUL1	6606.0
ZNF680	6619.0
ZNF205	6677.0
UBE2E1	6712.0
ZNF799	6729.0
PPP2CA	6732.0
PAF1	6756.0
PF4	6765.0
TNFRSF10B	6771.0
DDX39A	6778.0
COX7A2L	6791.0
INTS1	6802.0
ZNF701	6851.0
MED24	6882.0
BMAL1	6885.0
LAMTOR3	6901.0
H4C6	6913.0
ZNF662	6925.0
RARG	6965.0
POLR2D	6966.0
ZNF556	6973.0
NR4A1	7011.0
IWS1	7043.0
STK11	7060.0
PPP1R13L	7087.0
INTS6	7094.0
MIR24-1	7107.0
ZNF791	7109.0
TGIF2	7115.0
GATA2	7123.0
G6PC1	7140.0
PCF11	7189.0
DAXX	7214.0
BID	7226.0
NFYC	7262.0
ZNF563	7327.0
ZNF586	7362.0
RFFL	7379.0
ESRRA	7396.0
SNRPE	7418.0
SRF	7428.0
SMARCB1	7448.0
NOP2	7475.0
CLDN5	7517.0
DDIT4	7546.0
COX18	7562.0
CR1	7578.0
E2F4	7589.0
ERCC2	7598.0
THRA	7615.0
ZNF214	7630.0
DDX39B	7649.0
KAT5	7650.0
ARID1A	7657.0
LSM10	7678.0
RRAGD	7725.0
U2AF2	7762.0
OPRM1	7763.0
ZNF287	7818.0
ITGA2B	7920.0
ZNF577	7939.0
CAMK2B	7941.0
HDAC11	8052.0
TP53RK	8056.0
BRPF1	8061.0
NDRG1	8118.0
PHAX	8204.0
TP53INP1	8218.0
NOTCH2	8250.0
CAT	8268.0
CHD3	8284.0
ZNF736	8301.0
ZNF202	8305.0
ZNF382	8309.0
DDIT3	8338.0
CAMK2A	8344.0
TEAD3	8352.0
USP7	8359.0
CDK12	8371.0
SUPT6H	8377.0
CCNG2	8380.0
TCEA1	8431.0
RRM2B	8442.0
MTA2	8453.0
VENTX	8480.0
MYBL2	8516.0
ZNF727	8536.0
ZFPM1	8576.0
ZNF514	8601.0
TEAD4	8672.0
ZNF626	8772.0
ZNF583	8780.0
KAT2A	8790.0
COX8A	8793.0
ZNF274	8872.0
NR0B2	8928.0
TRIM63	8969.0
MYL9	9010.0
ZNF569	9015.0
TAF8	9095.0
TFAP2E	9106.0
POMC	9158.0
ZNF716	9218.0
ARNT	9225.0
STUB1	9249.0
NR2F6	9258.0
SMARCC1	9261.0
RYBP	9263.0
RUNX3	9284.0
ZNF101	9328.0
TAF10	9342.0
SEM1	9392.0
CPSF1	9453.0
ARID3A	9522.0
GPS2	9588.0
KMT2B	9642.0
RPA2	9677.0
ZNF717	9779.0
SFN	9832.0
ZNF675	9842.0
SCO2	9843.0
NELFCD	9891.0
H2AC14	9915.0
TAF7	9925.0
ZNF860	9956.0
CTSK	9957.0
CDK5R1	9974.0
ZNF486	10005.0
MDM4	10012.0
CGB8	10031.0
INS	10119.0
BTG2	10120.0
ZNF320	10213.0
RORC	10235.0
AGO1	10289.0
CTLA4	10350.0
UCMA	10395.0

---

REACTOME_CELL_CYCLE

REACTOME_CELL_CYCLE

	190
set	REACTOME_CELL_CYCLE
setSize	666
pANOVA	2.83e-09
s.dist	-0.135
p.adjustANOVA	2.32e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
TEX15	-10877.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
RHNO1	-10392.0
TUBAL3	-10372.0
CHMP4C	-10367.0
E2F1	-10358.0
RB1	-10297.0
TUBB2A	-10278.0
GOLGA2	-10275.0
POLE4	-10274.0
ZWINT	-10230.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
TEX15	-10877.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
RHNO1	-10392.0
TUBAL3	-10372.0
CHMP4C	-10367.0
E2F1	-10358.0
RB1	-10297.0
TUBB2A	-10278.0
GOLGA2	-10275.0
POLE4	-10274.0
ZWINT	-10230.0
CDKN1C	-10191.0
YWHAB	-10128.0
NUP85	-10122.0
PCBP4	-10096.0
H3C4	-10062.0
DYNLL1	-10008.0
ODF2	-9954.0
CENPE	-9941.0
TOP3A	-9928.0
GINS3	-9921.0
H4C9	-9887.0
REC8	-9877.0
H4C12	-9845.0
CCP110	-9836.0
TFDP1	-9800.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
RUVBL1	-9655.0
SPC24	-9653.0
NEK9	-9647.0
SMC4	-9624.0
TYMS	-9613.0
H2BC8	-9584.0
CCNE2	-9570.0
NCAPH	-9566.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
YWHAQ	-9275.0
PSMC3	-9217.0
XPO1	-9161.0
CNEP1R1	-9147.0
MIS18A	-9146.0
RBL1	-9102.0
BRCA1	-9099.0
CDKN2B	-9096.0
PSMA7	-9072.0
HAUS5	-9053.0
NPM1	-9022.0
CEP76	-9017.0
H3C11	-9013.0
MIS12	-8977.0
DYNLL2	-8918.0
BIRC5	-8888.0
PSMD9	-8887.0
MSH4	-8868.0
MCM4	-8837.0
DSCC1	-8823.0
PSMA6	-8781.0
WAPL	-8778.0
CENPW	-8754.0
PSMB10	-8751.0
CHMP4B	-8724.0
PRKACA	-8712.0
MRE11	-8696.0
H2BC15	-8620.0
CDC25B	-8586.0
PSMC2	-8506.0
OPTN	-8433.0
RFC5	-8423.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
TUBGCP4	-8249.0
PLK4	-8111.0
HJURP	-8086.0
HAUS6	-8080.0
CDKN2A	-8076.0
CDK5RAP2	-7957.0
H4C13	-7923.0
H3C6	-7918.0
CDC7	-7868.0
PSMF1	-7828.0
CSNK1E	-7784.0
NDC1	-7758.0
DCTN2	-7732.0
CSNK2A2	-7701.0
VRK2	-7676.0
RBBP8	-7671.0
PSMB3	-7613.0
MAPK3	-7607.0
SPC25	-7594.0
WEE1	-7583.0
FKBPL	-7556.0
CDK4	-7529.0
NINL	-7514.0
BUB1	-7509.0
ATM	-7508.0
SKA1	-7499.0
ATRIP	-7443.0
NUP153	-7417.0
TUBB	-7392.0
PPP1R12A	-7391.0
UBE2V2	-7378.0
POLD2	-7345.0
TOPBP1	-7343.0
BRCA2	-7328.0
CEP63	-7295.0
PRIM2	-7259.0
TMPO	-7209.0
TOP2A	-7200.0
FBXO5	-7188.0
KIF2B	-7174.0
TERF2IP	-7165.0
NUP50	-7103.0
CEP152	-7092.0
DCTN3	-7069.0
LBR	-7065.0
CCNE1	-7048.0
CENPA	-7025.0
PSMA4	-6953.0
ZNF385A	-6942.0
ORC1	-6900.0
SKP1	-6898.0
CENPF	-6868.0
SIRT2	-6851.0
MCM8	-6772.0
NEDD1	-6757.0
HSP90AA1	-6752.0
MDM2	-6733.0
PSMB8	-6727.0
E2F2	-6669.0
SGO2	-6645.0
ORC5	-6642.0
MLH1	-6596.0
BABAM2	-6564.0
SYCE3	-6558.0
GINS1	-6555.0
KNL1	-6549.0
CNTRL	-6497.0
PSMB1	-6458.0
TINF2	-6451.0
MZT2B	-6428.0
LIG1	-6397.0
MAD2L1	-6363.0
RFC4	-6357.0
NUP35	-6340.0
PPP2R1B	-6311.0
CDK7	-6225.0
PPP2R5B	-6192.0
ANAPC5	-6173.0
RAD51	-6165.0
POLR2G	-6150.0
VRK1	-6053.0
RBL2	-6043.0
RAB2A	-6038.0
RCC1	-6013.0
H4C8	-5994.0
PPP2R5D	-5981.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
YWHAH	-5939.0
PRIM1	-5927.0
RPS27A	-5922.0
TERF2	-5913.0
CHMP4A	-5881.0
ANKLE2	-5870.0
NCAPD2	-5867.0
NUP107	-5851.0
CENPJ	-5832.0
SMC2	-5782.0
H2AZ2	-5775.0
E2F3	-5757.0
H2BC11	-5756.0
TUBB8	-5716.0
RFC1	-5699.0
ANKRD28	-5670.0
MLH3	-5618.0
WRAP53	-5607.0
BTRC	-5601.0
MAU2	-5574.0
KPNB1	-5545.0
DBF4	-5544.0
PCNT	-5487.0
NDC80	-5484.0
PSMD4	-5443.0
DYNC1LI1	-5413.0
MCPH1	-5392.0
CHEK1	-5363.0
DHFR	-5360.0
GORASP1	-5340.0
PSMB5	-5303.0
CSNK2B	-5291.0
UBB	-5278.0
SMARCA5	-5263.0
POLA2	-5226.0
USO1	-5204.0
SGO1	-5198.0
NUDC	-5184.0
FOXM1	-5178.0
MZT2A	-5166.0
HAUS4	-5164.0
CCNB1	-5146.0
COP1	-5111.0
CHTF18	-5081.0
PSMA3	-5040.0
CENPP	-4981.0
KIF2A	-4900.0
ESCO1	-4891.0
H3C2	-4876.0
POLR2H	-4815.0
TUBG1	-4811.0
TUBB4A	-4807.0
NUP160	-4777.0
SPO11	-4713.0
SMC3	-4651.0
NBN	-4575.0
AJUBA	-4514.0
ATR	-4504.0
CLASP2	-4463.0
MNAT1	-4434.0
EML4	-4389.0
BANF1	-4346.0
CDC45	-4296.0
PDS5B	-4294.0
PPP2R1A	-4275.0
MAD1L1	-4226.0
NUP93	-4202.0
RANBP2	-4186.0
KIF2C	-4164.0
TNPO1	-4140.0
NUP37	-4123.0
SEC13	-4109.0
PCM1	-4085.0
POM121	-4065.0
POLR2L	-4064.0
GSK3B	-4058.0
CCNA1	-4010.0
MAPRE1	-4007.0
BARD1	-3957.0
TP53	-3947.0
NUP98	-3940.0
CKS1B	-3938.0
MASTL	-3904.0
DYRK1A	-3900.0
LIN52	-3889.0
SPDL1	-3860.0
LCMT1	-3857.0
NUP88	-3822.0
HAUS3	-3760.0
POLE3	-3713.0
LEMD3	-3710.0
ZWILCH	-3655.0
PPME1	-3645.0
GINS2	-3613.0
CENPL	-3607.0
BLM	-3594.0
TUBGCP2	-3575.0
RMI2	-3522.0
BRIP1	-3490.0
CHTF8	-3481.0
AKAP9	-3477.0
HAUS1	-3468.0
WRN	-3454.0
CEP43	-3422.0
SKA2	-3415.0
TUBGCP5	-3405.0
TFDP2	-3304.0
INCENP	-3300.0
NUP54	-3291.0
HDAC1	-3246.0
PSMB7	-3196.0
DYNC1I1	-3186.0
CEP164	-3164.0
MCM3	-3095.0
PPP2R2A	-3068.0
NCAPG2	-3067.0
RBBP4	-3061.0
ANAPC10	-3050.0
PSMA1	-3041.0
RAB1B	-3018.0
HMMR	-2983.0
POLR2I	-2974.0
H4C4	-2969.0
RAD17	-2958.0
CC2D1B	-2934.0
TUBA1B	-2907.0
TPX2	-2887.0
NIPBL	-2883.0
CEP70	-2853.0
TUBA1C	-2799.0
MAX	-2796.0
RSF1	-2759.0
TP53BP1	-2701.0
TPR	-2693.0
ORC4	-2672.0
ORC6	-2669.0
NUP205	-2604.0
PSMC5	-2598.0
IST1	-2589.0
PSMD7	-2547.0
NEK7	-2533.0
H4C11	-2506.0
CENPQ	-2491.0
CHMP2A	-2484.0
CHMP7	-2480.0
ANAPC11	-2468.0
MDC1	-2451.0
KIF18A	-2373.0
CDC14A	-2349.0
UBE2D1	-2260.0
CEP72	-2259.0
SYCP2	-2199.0
TUBA8	-2181.0
POLE	-2169.0
H2BC4	-2161.0
YWHAZ	-2100.0
UBC	-2067.0
NUP214	-2055.0
H2AC6	-2051.0
UBE2N	-2050.0
NDEL1	-2044.0
TUBA3C	-2009.0
CLSPN	-1972.0
DYNC1LI2	-1905.0
CENPC	-1901.0
RFC3	-1900.0
RMI1	-1872.0
MND1	-1870.0
POM121C	-1851.0
CSNK2A1	-1846.0
PPP2R5C	-1840.0
ANAPC4	-1807.0
SYNE1	-1758.0
PRKCB	-1707.0
FBXL7	-1634.0
VPS4A	-1614.0
OIP5	-1613.0
MCM6	-1605.0
PIF1	-1457.0
KIF23	-1455.0
LMNA	-1442.0
EP300	-1428.0
STAG1	-1424.0
H4C5	-1423.0
H3-3A	-1342.0
MCM10	-1302.0
SHQ1	-1250.0
HUS1	-1217.0
PAFAH1B1	-1210.0
SYNE2	-1194.0
HSP90AB1	-1174.0
DNA2	-1169.0
POLR2F	-1161.0
CCNH	-1145.0
RANGAP1	-1144.0
PSMB6	-1085.0
B9D2	-1005.0
H2BC5	-999.0
RNF8	-986.0
UIMC1	-983.0
PSMA5	-964.0
PSMB4	-949.0
PRKAR2B	-934.0
NCAPD3	-911.0
CCNB2	-898.0
ENSA	-882.0
CCND2	-858.0
CDC25A	-853.0
YWHAG	-766.0
PSMA2	-698.0
POLR2A	-696.0
CTDNEP1	-683.0
NME7	-669.0
NOP10	-668.0
KNTC1	-667.0
DSN1	-642.0
TUBA3E	-637.0
PPP2R5E	-634.0
ACTR1A	-611.0
TUBB2B	-608.0
CDC16	-598.0
SUN1	-595.0
GINS4	-496.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
CDC6	-419.0
RPA3	-298.0
AKT3	-289.0
NSD2	-283.0
RBX1	-261.0
ITGB3BP	-255.0
NCAPG	-250.0
POT1	-227.0
HSPA2	-223.0
SRC	-215.0
PTK6	-182.0
CEP78	-180.0
CDC26	-126.0
ORC2	-95.0
ALMS1	-87.0
PSMD11	-47.0
CDKN1A	1.0
RAB8A	4.0
FKBP6	47.0
PCNA	79.0
CLASP1	104.0
BLZF1	123.0
SKP2	169.0
CDC20	243.0
DCTN1	261.0
CCNA2	268.0
PSME3	308.0
SDCCAG8	367.0
H4C3	423.0
PPP1R12B	442.0
LPIN1	489.0
CSNK1D	501.0
PPP6R3	529.0
LIN54	530.0
PRKCA	547.0
CEP41	582.0
UBE2I	584.0
CDK1	604.0
CDT1	645.0
LEMD2	667.0
PSMB9	675.0
CDCA5	744.0
CENPU	759.0
CEP192	764.0
CDK6	783.0
NEK2	796.0
SUMO1	802.0
ANAPC7	838.0
KMT5A	861.0
PPP2R5A	866.0
CLIP1	884.0
PHLDA1	907.0
GAR1	953.0
TEX12	994.0
CKAP5	1008.0
PSMC3IP	1060.0
RAD50	1099.0
STAG3	1111.0
CENPN	1116.0
POLD1	1119.0
PSMD5	1121.0
CDC25C	1212.0
AHCTF1	1236.0
H4C16	1337.0
HERC2	1352.0
NCAPH2	1353.0
AAAS	1385.0
TEN1	1470.0
MYC	1474.0
PSMD12	1518.0
MCM2	1539.0
MAPK1	1551.0
HAUS2	1587.0
TUBGCP3	1594.0
ABL1	1646.0
CDC23	1666.0
H2AJ	1704.0
NUP133	1721.0
ESPL1	1759.0
SMC1B	1798.0
PSMD13	1814.0
YWHAE	1817.0
LMNB1	1840.0
NUP155	1883.0
CDK2	1892.0
TERF1	1919.0
H2BC3	1965.0
CHMP3	1967.0
PSMC4	1992.0
CENPT	2001.0
ACD	2104.5
NUP58	2106.0
CEP290	2164.0
RFC2	2285.0
H3-4	2321.0
MSH5	2404.0
CENPO	2415.0
H2BC21	2421.0
PHF20	2500.0
NUF2	2503.0
PSMD3	2572.0
NDE1	2582.0
PIAS4	2600.0
RAD1	2602.0
SEH1L	2648.0
CEP135	2694.0
CDCA8	2698.0
PSMB2	2710.0
FBXL18	2726.0
H2AZ1	2761.0
FBXW11	2768.0
ANAPC2	2780.0
DIDO1	2794.0
POLR2B	2810.0
CTC1	2901.0
UBA52	2905.0
CCND1	2977.0
TUBA4B	3110.0
CABLES1	3111.0
LIN9	3136.0
SPAST	3237.0
ORC3	3240.0
DYNC1I2	3247.0
SYCP3	3255.0
RRM2	3305.0
TAOK1	3350.0
PLK1	3423.0
E2F6	3430.0
LIN37	3448.0
CENPH	3473.0
RAD9A	3485.0
PTTG1	3519.0
PSMC1	3545.0
EXO1	3564.0
DYNC1H1	3577.0
BUB3	3598.0
CDKN1B	3615.0
RAE1	3695.0
AURKA	3712.0
TUBB3	3736.0
POLD3	3753.0
PSME4	3824.0
AKT2	3850.0
MIS18BP1	3889.0
RAD21	3920.0
POLR2J	4123.0
KIF20A	4150.0
RAN	4175.0
HAUS8	4192.0
SFI1	4288.0
PPP2R2D	4394.0
NUP188	4396.0
NUP42	4406.0
CEP57	4409.0
H4C2	4419.0
CCND3	4478.0
ZW10	4480.0
PSME2	4493.0
RPS27	4496.0
SUN2	4523.0
NUMA1	4544.0
SYCE1	4551.0
POLR2C	4579.0
FZR1	4599.0
SYCP1	4612.0
PPP2CB	4668.0
CDKN2C	4767.0
STN1	4861.0
TUBG2	4879.0
PSMA8	4885.0
H3C3	4893.0
RAD9B	4895.0
CDK11A	4942.0
BABAM1	4984.0
GTSE1	4995.0
CHEK2	5010.0
SSNA1	5028.0
H2AC20	5150.0
RAB1A	5210.0
AURKB	5224.0
PPP1CB	5293.0
CDC27	5348.0
CDK11B	5358.0
CENPK	5388.0
POLD4	5396.0
NSL1	5459.0
TUBA4A	5567.0
PDS5A	5596.0
AKT1	5667.0
ANAPC1	5774.0
TERT	5815.0
ESCO2	5838.0
ANAPC15	5844.0
RUVBL2	5893.0
CEP250	5926.0
SYCE2	5965.0
H2BC14	6016.0
TUBA1A	6100.0
NUP43	6107.0
ARPP19	6160.0
RPA1	6175.0
ANAPC16	6225.0
H2BC1	6290.0
PSME1	6314.0
LPIN2	6336.0
LYN	6357.0
H3C1	6458.0
RNF168	6513.0
POLR2E	6530.0
E2F5	6570.0
PPP1CC	6592.0
CUL1	6606.0
CHMP6	6620.0
LPIN3	6693.0
UBE2E1	6712.0
PPP2CA	6732.0
CEP131	6826.0
TUBB4B	6910.0
H4C6	6913.0
DMC1	6937.0
CHMP2B	6950.0
MZT1	6960.0
POLR2D	6966.0
TUBB6	7030.0
TK1	7102.0
DAXX	7214.0
RCC2	7254.0
JAK2	7276.0
CENPM	7288.0
ABRAXAS1	7405.0
E2F4	7589.0
NHP2	7635.0
KAT5	7650.0
BUB1B	7699.0
TUBB1	7729.0
NUP210	7811.0
MCM7	7817.0
BORA	7844.0
NUP62	7909.0
FEN1	7913.0
PKMYT1	7970.0
GMNN	7984.0
RAD51C	7987.0
RTEL1	8029.0
NEK6	8099.0
PMF1	8129.0
TUBGCP6	8154.0
SET	8189.0
PRDM9	8445.0
MYBL2	8516.0
CENPS	8690.0
PPP6C	8843.0
TUBA3D	8852.0
GORASP2	8919.0
SEM1	9392.0
RPA2	9677.0
SFN	9832.0
H2AC14	9915.0
MDM4	10012.0
MCM5	10021.0
CDKN2D	10040.0
POLE2	10051.0

---

REACTOME_CELL_CYCLE_MITOTIC

REACTOME_CELL_CYCLE_MITOTIC

	1112
set	REACTOME_CELL_CYCLE_MITOTIC
setSize	539
pANOVA	1.7e-08
s.dist	-0.142
p.adjustANOVA	7.86e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
CHMP4C	-10367.0
E2F1	-10358.0
RB1	-10297.0
TUBB2A	-10278.0
GOLGA2	-10275.0
POLE4	-10274.0
ZWINT	-10230.0
CDKN1C	-10191.0
NUP85	-10122.0
H3C4	-10062.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
CHMP4C	-10367.0
E2F1	-10358.0
RB1	-10297.0
TUBB2A	-10278.0
GOLGA2	-10275.0
POLE4	-10274.0
ZWINT	-10230.0
CDKN1C	-10191.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
ODF2	-9954.0
CENPE	-9941.0
GINS3	-9921.0
H4C9	-9887.0
H4C12	-9845.0
CCP110	-9836.0
TFDP1	-9800.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
SPC24	-9653.0
NEK9	-9647.0
SMC4	-9624.0
TYMS	-9613.0
H2BC8	-9584.0
CCNE2	-9570.0
NCAPH	-9566.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
XPO1	-9161.0
CNEP1R1	-9147.0
RBL1	-9102.0
CDKN2B	-9096.0
PSMA7	-9072.0
HAUS5	-9053.0
CEP76	-9017.0
H3C11	-9013.0
MIS12	-8977.0
DYNLL2	-8918.0
BIRC5	-8888.0
PSMD9	-8887.0
MCM4	-8837.0
PSMA6	-8781.0
WAPL	-8778.0
PSMB10	-8751.0
CHMP4B	-8724.0
PRKACA	-8712.0
H2BC15	-8620.0
CDC25B	-8586.0
PSMC2	-8506.0
OPTN	-8433.0
RFC5	-8423.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
TUBGCP4	-8249.0
PLK4	-8111.0
HAUS6	-8080.0
CDKN2A	-8076.0
CDK5RAP2	-7957.0
H4C13	-7923.0
H3C6	-7918.0
CDC7	-7868.0
PSMF1	-7828.0
CSNK1E	-7784.0
NDC1	-7758.0
DCTN2	-7732.0
CSNK2A2	-7701.0
VRK2	-7676.0
PSMB3	-7613.0
MAPK3	-7607.0
SPC25	-7594.0
WEE1	-7583.0
FKBPL	-7556.0
CDK4	-7529.0
NINL	-7514.0
BUB1	-7509.0
SKA1	-7499.0
NUP153	-7417.0
TUBB	-7392.0
PPP1R12A	-7391.0
POLD2	-7345.0
CEP63	-7295.0
PRIM2	-7259.0
TMPO	-7209.0
TOP2A	-7200.0
FBXO5	-7188.0
KIF2B	-7174.0
NUP50	-7103.0
CEP152	-7092.0
DCTN3	-7069.0
LBR	-7065.0
CCNE1	-7048.0
CENPA	-7025.0
PSMA4	-6953.0
ORC1	-6900.0
SKP1	-6898.0
CENPF	-6868.0
SIRT2	-6851.0
MCM8	-6772.0
NEDD1	-6757.0
HSP90AA1	-6752.0
PSMB8	-6727.0
E2F2	-6669.0
SGO2	-6645.0
ORC5	-6642.0
GINS1	-6555.0
KNL1	-6549.0
CNTRL	-6497.0
PSMB1	-6458.0
MZT2B	-6428.0
LIG1	-6397.0
MAD2L1	-6363.0
RFC4	-6357.0
NUP35	-6340.0
PPP2R1B	-6311.0
CDK7	-6225.0
PPP2R5B	-6192.0
ANAPC5	-6173.0
VRK1	-6053.0
RBL2	-6043.0
RAB2A	-6038.0
RCC1	-6013.0
H4C8	-5994.0
PPP2R5D	-5981.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
PRIM1	-5927.0
RPS27A	-5922.0
CHMP4A	-5881.0
ANKLE2	-5870.0
NCAPD2	-5867.0
NUP107	-5851.0
CENPJ	-5832.0
SMC2	-5782.0
H2AZ2	-5775.0
E2F3	-5757.0
H2BC11	-5756.0
TUBB8	-5716.0
RFC1	-5699.0
BTRC	-5601.0
MAU2	-5574.0
KPNB1	-5545.0
DBF4	-5544.0
PCNT	-5487.0
NDC80	-5484.0
PSMD4	-5443.0
DYNC1LI1	-5413.0
MCPH1	-5392.0
DHFR	-5360.0
GORASP1	-5340.0
PSMB5	-5303.0
CSNK2B	-5291.0
UBB	-5278.0
POLA2	-5226.0
USO1	-5204.0
SGO1	-5198.0
NUDC	-5184.0
FOXM1	-5178.0
MZT2A	-5166.0
HAUS4	-5164.0
CCNB1	-5146.0
PSMA3	-5040.0
CENPP	-4981.0
KIF2A	-4900.0
ESCO1	-4891.0
H3C2	-4876.0
TUBG1	-4811.0
TUBB4A	-4807.0
NUP160	-4777.0
SMC3	-4651.0
AJUBA	-4514.0
CLASP2	-4463.0
MNAT1	-4434.0
EML4	-4389.0
BANF1	-4346.0
CDC45	-4296.0
PDS5B	-4294.0
PPP2R1A	-4275.0
MAD1L1	-4226.0
NUP93	-4202.0
RANBP2	-4186.0
KIF2C	-4164.0
TNPO1	-4140.0
NUP37	-4123.0
SEC13	-4109.0
PCM1	-4085.0
POM121	-4065.0
GSK3B	-4058.0
CCNA1	-4010.0
MAPRE1	-4007.0
TP53	-3947.0
NUP98	-3940.0
CKS1B	-3938.0
MASTL	-3904.0
DYRK1A	-3900.0
LIN52	-3889.0
SPDL1	-3860.0
LCMT1	-3857.0
NUP88	-3822.0
HAUS3	-3760.0
POLE3	-3713.0
LEMD3	-3710.0
ZWILCH	-3655.0
PPME1	-3645.0
GINS2	-3613.0
CENPL	-3607.0
TUBGCP2	-3575.0
AKAP9	-3477.0
HAUS1	-3468.0
CEP43	-3422.0
SKA2	-3415.0
TUBGCP5	-3405.0
TFDP2	-3304.0
INCENP	-3300.0
NUP54	-3291.0
HDAC1	-3246.0
PSMB7	-3196.0
DYNC1I1	-3186.0
CEP164	-3164.0
MCM3	-3095.0
PPP2R2A	-3068.0
NCAPG2	-3067.0
RBBP4	-3061.0
ANAPC10	-3050.0
PSMA1	-3041.0
RAB1B	-3018.0
HMMR	-2983.0
H4C4	-2969.0
CC2D1B	-2934.0
TUBA1B	-2907.0
TPX2	-2887.0
NIPBL	-2883.0
CEP70	-2853.0
TUBA1C	-2799.0
MAX	-2796.0
TPR	-2693.0
ORC4	-2672.0
ORC6	-2669.0
NUP205	-2604.0
PSMC5	-2598.0
IST1	-2589.0
PSMD7	-2547.0
NEK7	-2533.0
H4C11	-2506.0
CENPQ	-2491.0
CHMP2A	-2484.0
CHMP7	-2480.0
ANAPC11	-2468.0
KIF18A	-2373.0
CDC14A	-2349.0
UBE2D1	-2260.0
CEP72	-2259.0
TUBA8	-2181.0
POLE	-2169.0
H2BC4	-2161.0
UBC	-2067.0
NUP214	-2055.0
H2AC6	-2051.0
NDEL1	-2044.0
TUBA3C	-2009.0
DYNC1LI2	-1905.0
CENPC	-1901.0
RFC3	-1900.0
POM121C	-1851.0
CSNK2A1	-1846.0
PPP2R5C	-1840.0
ANAPC4	-1807.0
PRKCB	-1707.0
FBXL7	-1634.0
VPS4A	-1614.0
MCM6	-1605.0
KIF23	-1455.0
LMNA	-1442.0
EP300	-1428.0
STAG1	-1424.0
H4C5	-1423.0
H3-3A	-1342.0
MCM10	-1302.0
PAFAH1B1	-1210.0
HSP90AB1	-1174.0
DNA2	-1169.0
CCNH	-1145.0
RANGAP1	-1144.0
PSMB6	-1085.0
B9D2	-1005.0
H2BC5	-999.0
PSMA5	-964.0
PSMB4	-949.0
PRKAR2B	-934.0
NCAPD3	-911.0
CCNB2	-898.0
ENSA	-882.0
CCND2	-858.0
CDC25A	-853.0
YWHAG	-766.0
PSMA2	-698.0
CTDNEP1	-683.0
NME7	-669.0
KNTC1	-667.0
DSN1	-642.0
TUBA3E	-637.0
PPP2R5E	-634.0
ACTR1A	-611.0
TUBB2B	-608.0
CDC16	-598.0
GINS4	-496.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
CDC6	-419.0
RPA3	-298.0
AKT3	-289.0
RBX1	-261.0
ITGB3BP	-255.0
NCAPG	-250.0
SRC	-215.0
PTK6	-182.0
CEP78	-180.0
CDC26	-126.0
ORC2	-95.0
ALMS1	-87.0
PSMD11	-47.0
CDKN1A	1.0
RAB8A	4.0
PCNA	79.0
CLASP1	104.0
BLZF1	123.0
SKP2	169.0
CDC20	243.0
DCTN1	261.0
CCNA2	268.0
PSME3	308.0
SDCCAG8	367.0
H4C3	423.0
PPP1R12B	442.0
LPIN1	489.0
CSNK1D	501.0
LIN54	530.0
PRKCA	547.0
CEP41	582.0
UBE2I	584.0
CDK1	604.0
CDT1	645.0
LEMD2	667.0
PSMB9	675.0
CDCA5	744.0
CENPU	759.0
CEP192	764.0
CDK6	783.0
NEK2	796.0
SUMO1	802.0
ANAPC7	838.0
KMT5A	861.0
PPP2R5A	866.0
CLIP1	884.0
PHLDA1	907.0
CKAP5	1008.0
CENPN	1116.0
POLD1	1119.0
PSMD5	1121.0
CDC25C	1212.0
AHCTF1	1236.0
H4C16	1337.0
NCAPH2	1353.0
AAAS	1385.0
MYC	1474.0
PSMD12	1518.0
MCM2	1539.0
MAPK1	1551.0
HAUS2	1587.0
TUBGCP3	1594.0
ABL1	1646.0
CDC23	1666.0
H2AJ	1704.0
NUP133	1721.0
ESPL1	1759.0
PSMD13	1814.0
YWHAE	1817.0
LMNB1	1840.0
NUP155	1883.0
CDK2	1892.0
H2BC3	1965.0
CHMP3	1967.0
PSMC4	1992.0
CENPT	2001.0
NUP58	2106.0
CEP290	2164.0
RFC2	2285.0
H3-4	2321.0
CENPO	2415.0
H2BC21	2421.0
NUF2	2503.0
PSMD3	2572.0
NDE1	2582.0
SEH1L	2648.0
CEP135	2694.0
CDCA8	2698.0
PSMB2	2710.0
FBXL18	2726.0
H2AZ1	2761.0
FBXW11	2768.0
ANAPC2	2780.0
UBA52	2905.0
CCND1	2977.0
TUBA4B	3110.0
CABLES1	3111.0
LIN9	3136.0
SPAST	3237.0
ORC3	3240.0
DYNC1I2	3247.0
RRM2	3305.0
TAOK1	3350.0
PLK1	3423.0
E2F6	3430.0
LIN37	3448.0
CENPH	3473.0
PTTG1	3519.0
PSMC1	3545.0
DYNC1H1	3577.0
BUB3	3598.0
CDKN1B	3615.0
RAE1	3695.0
AURKA	3712.0
TUBB3	3736.0
POLD3	3753.0
PSME4	3824.0
AKT2	3850.0
RAD21	3920.0
KIF20A	4150.0
RAN	4175.0
HAUS8	4192.0
SFI1	4288.0
PPP2R2D	4394.0
NUP188	4396.0
NUP42	4406.0
CEP57	4409.0
H4C2	4419.0
CCND3	4478.0
ZW10	4480.0
PSME2	4493.0
RPS27	4496.0
NUMA1	4544.0
FZR1	4599.0
PPP2CB	4668.0
CDKN2C	4767.0
TUBG2	4879.0
PSMA8	4885.0
H3C3	4893.0
CDK11A	4942.0
GTSE1	4995.0
SSNA1	5028.0
H2AC20	5150.0
RAB1A	5210.0
AURKB	5224.0
PPP1CB	5293.0
CDC27	5348.0
CDK11B	5358.0
CENPK	5388.0
POLD4	5396.0
NSL1	5459.0
TUBA4A	5567.0
PDS5A	5596.0
AKT1	5667.0
ANAPC1	5774.0
ESCO2	5838.0
ANAPC15	5844.0
CEP250	5926.0
H2BC14	6016.0
TUBA1A	6100.0
NUP43	6107.0
ARPP19	6160.0
RPA1	6175.0
ANAPC16	6225.0
H2BC1	6290.0
PSME1	6314.0
LPIN2	6336.0
LYN	6357.0
H3C1	6458.0
E2F5	6570.0
PPP1CC	6592.0
CUL1	6606.0
CHMP6	6620.0
LPIN3	6693.0
UBE2E1	6712.0
PPP2CA	6732.0
CEP131	6826.0
TUBB4B	6910.0
H4C6	6913.0
CHMP2B	6950.0
MZT1	6960.0
TUBB6	7030.0
TK1	7102.0
RCC2	7254.0
JAK2	7276.0
CENPM	7288.0
E2F4	7589.0
BUB1B	7699.0
TUBB1	7729.0
NUP210	7811.0
MCM7	7817.0
BORA	7844.0
NUP62	7909.0
FEN1	7913.0
PKMYT1	7970.0
GMNN	7984.0
NEK6	8099.0
PMF1	8129.0
TUBGCP6	8154.0
SET	8189.0
MYBL2	8516.0
CENPS	8690.0
TUBA3D	8852.0
GORASP2	8919.0
SEM1	9392.0
RPA2	9677.0
H2AC14	9915.0
MCM5	10021.0
CDKN2D	10040.0
POLE2	10051.0

---

REACTOME_M_PHASE

REACTOME_M_PHASE

	1096
set	REACTOME_M_PHASE
setSize	398
pANOVA	1.92e-08
s.dist	-0.164
p.adjustANOVA	7.86e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
CHMP4C	-10367.0
RB1	-10297.0
TUBB2A	-10278.0
GOLGA2	-10275.0
ZWINT	-10230.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
ODF2	-9954.0
CENPE	-9941.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
CHMP4C	-10367.0
RB1	-10297.0
TUBB2A	-10278.0
GOLGA2	-10275.0
ZWINT	-10230.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
ODF2	-9954.0
CENPE	-9941.0
H4C9	-9887.0
H4C12	-9845.0
CCP110	-9836.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
SPC24	-9653.0
NEK9	-9647.0
SMC4	-9624.0
H2BC8	-9584.0
NCAPH	-9566.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
XPO1	-9161.0
CNEP1R1	-9147.0
PSMA7	-9072.0
HAUS5	-9053.0
CEP76	-9017.0
H3C11	-9013.0
MIS12	-8977.0
DYNLL2	-8918.0
BIRC5	-8888.0
PSMD9	-8887.0
PSMA6	-8781.0
WAPL	-8778.0
PSMB10	-8751.0
CHMP4B	-8724.0
PRKACA	-8712.0
H2BC15	-8620.0
PSMC2	-8506.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
TUBGCP4	-8249.0
PLK4	-8111.0
HAUS6	-8080.0
CDK5RAP2	-7957.0
H4C13	-7923.0
H3C6	-7918.0
PSMF1	-7828.0
CSNK1E	-7784.0
NDC1	-7758.0
DCTN2	-7732.0
CSNK2A2	-7701.0
VRK2	-7676.0
PSMB3	-7613.0
MAPK3	-7607.0
SPC25	-7594.0
NINL	-7514.0
BUB1	-7509.0
SKA1	-7499.0
NUP153	-7417.0
TUBB	-7392.0
CEP63	-7295.0
TMPO	-7209.0
FBXO5	-7188.0
KIF2B	-7174.0
NUP50	-7103.0
CEP152	-7092.0
DCTN3	-7069.0
LBR	-7065.0
CENPA	-7025.0
PSMA4	-6953.0
CENPF	-6868.0
SIRT2	-6851.0
NEDD1	-6757.0
HSP90AA1	-6752.0
PSMB8	-6727.0
SGO2	-6645.0
KNL1	-6549.0
CNTRL	-6497.0
PSMB1	-6458.0
MZT2B	-6428.0
MAD2L1	-6363.0
NUP35	-6340.0
PPP2R1B	-6311.0
PPP2R5B	-6192.0
ANAPC5	-6173.0
VRK1	-6053.0
RAB2A	-6038.0
RCC1	-6013.0
H4C8	-5994.0
PPP2R5D	-5981.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
CHMP4A	-5881.0
ANKLE2	-5870.0
NCAPD2	-5867.0
NUP107	-5851.0
CENPJ	-5832.0
SMC2	-5782.0
H2AZ2	-5775.0
H2BC11	-5756.0
TUBB8	-5716.0
MAU2	-5574.0
KPNB1	-5545.0
PCNT	-5487.0
NDC80	-5484.0
PSMD4	-5443.0
DYNC1LI1	-5413.0
MCPH1	-5392.0
GORASP1	-5340.0
PSMB5	-5303.0
CSNK2B	-5291.0
UBB	-5278.0
USO1	-5204.0
SGO1	-5198.0
NUDC	-5184.0
MZT2A	-5166.0
HAUS4	-5164.0
CCNB1	-5146.0
PSMA3	-5040.0
CENPP	-4981.0
KIF2A	-4900.0
H3C2	-4876.0
TUBG1	-4811.0
TUBB4A	-4807.0
NUP160	-4777.0
SMC3	-4651.0
CLASP2	-4463.0
EML4	-4389.0
BANF1	-4346.0
PDS5B	-4294.0
PPP2R1A	-4275.0
MAD1L1	-4226.0
NUP93	-4202.0
RANBP2	-4186.0
KIF2C	-4164.0
TNPO1	-4140.0
NUP37	-4123.0
SEC13	-4109.0
PCM1	-4085.0
POM121	-4065.0
MAPRE1	-4007.0
NUP98	-3940.0
MASTL	-3904.0
SPDL1	-3860.0
NUP88	-3822.0
HAUS3	-3760.0
LEMD3	-3710.0
ZWILCH	-3655.0
CENPL	-3607.0
TUBGCP2	-3575.0
AKAP9	-3477.0
HAUS1	-3468.0
CEP43	-3422.0
SKA2	-3415.0
TUBGCP5	-3405.0
INCENP	-3300.0
NUP54	-3291.0
PSMB7	-3196.0
DYNC1I1	-3186.0
CEP164	-3164.0
PPP2R2A	-3068.0
NCAPG2	-3067.0
ANAPC10	-3050.0
PSMA1	-3041.0
RAB1B	-3018.0
H4C4	-2969.0
CC2D1B	-2934.0
TUBA1B	-2907.0
NIPBL	-2883.0
CEP70	-2853.0
TUBA1C	-2799.0
TPR	-2693.0
NUP205	-2604.0
PSMC5	-2598.0
IST1	-2589.0
PSMD7	-2547.0
NEK7	-2533.0
H4C11	-2506.0
CENPQ	-2491.0
CHMP2A	-2484.0
CHMP7	-2480.0
ANAPC11	-2468.0
KIF18A	-2373.0
UBE2D1	-2260.0
CEP72	-2259.0
TUBA8	-2181.0
H2BC4	-2161.0
UBC	-2067.0
NUP214	-2055.0
H2AC6	-2051.0
NDEL1	-2044.0
TUBA3C	-2009.0
DYNC1LI2	-1905.0
CENPC	-1901.0
POM121C	-1851.0
CSNK2A1	-1846.0
PPP2R5C	-1840.0
ANAPC4	-1807.0
PRKCB	-1707.0
VPS4A	-1614.0
KIF23	-1455.0
LMNA	-1442.0
STAG1	-1424.0
H4C5	-1423.0
H3-3A	-1342.0
PAFAH1B1	-1210.0
RANGAP1	-1144.0
PSMB6	-1085.0
B9D2	-1005.0
H2BC5	-999.0
PSMA5	-964.0
PSMB4	-949.0
PRKAR2B	-934.0
NCAPD3	-911.0
CCNB2	-898.0
ENSA	-882.0
YWHAG	-766.0
PSMA2	-698.0
CTDNEP1	-683.0
NME7	-669.0
KNTC1	-667.0
DSN1	-642.0
TUBA3E	-637.0
PPP2R5E	-634.0
ACTR1A	-611.0
TUBB2B	-608.0
CDC16	-598.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
ITGB3BP	-255.0
NCAPG	-250.0
CEP78	-180.0
CDC26	-126.0
ALMS1	-87.0
PSMD11	-47.0
CLASP1	104.0
BLZF1	123.0
CDC20	243.0
DCTN1	261.0
PSME3	308.0
SDCCAG8	367.0
H4C3	423.0
LPIN1	489.0
CSNK1D	501.0
PRKCA	547.0
CEP41	582.0
UBE2I	584.0
CDK1	604.0
LEMD2	667.0
PSMB9	675.0
CDCA5	744.0
CENPU	759.0
CEP192	764.0
NEK2	796.0
SUMO1	802.0
ANAPC7	838.0
KMT5A	861.0
PPP2R5A	866.0
CLIP1	884.0
CKAP5	1008.0
CENPN	1116.0
PSMD5	1121.0
AHCTF1	1236.0
H4C16	1337.0
NCAPH2	1353.0
AAAS	1385.0
PSMD12	1518.0
MAPK1	1551.0
HAUS2	1587.0
TUBGCP3	1594.0
CDC23	1666.0
H2AJ	1704.0
NUP133	1721.0
ESPL1	1759.0
PSMD13	1814.0
YWHAE	1817.0
LMNB1	1840.0
NUP155	1883.0
H2BC3	1965.0
CHMP3	1967.0
PSMC4	1992.0
CENPT	2001.0
NUP58	2106.0
CEP290	2164.0
H3-4	2321.0
CENPO	2415.0
H2BC21	2421.0
NUF2	2503.0
PSMD3	2572.0
NDE1	2582.0
SEH1L	2648.0
CEP135	2694.0
CDCA8	2698.0
PSMB2	2710.0
H2AZ1	2761.0
ANAPC2	2780.0
UBA52	2905.0
TUBA4B	3110.0
SPAST	3237.0
DYNC1I2	3247.0
TAOK1	3350.0
PLK1	3423.0
CENPH	3473.0
PTTG1	3519.0
PSMC1	3545.0
DYNC1H1	3577.0
BUB3	3598.0
RAE1	3695.0
TUBB3	3736.0
PSME4	3824.0
RAD21	3920.0
KIF20A	4150.0
RAN	4175.0
HAUS8	4192.0
SFI1	4288.0
PPP2R2D	4394.0
NUP188	4396.0
NUP42	4406.0
CEP57	4409.0
H4C2	4419.0
ZW10	4480.0
PSME2	4493.0
RPS27	4496.0
NUMA1	4544.0
PPP2CB	4668.0
TUBG2	4879.0
PSMA8	4885.0
H3C3	4893.0
SSNA1	5028.0
H2AC20	5150.0
RAB1A	5210.0
AURKB	5224.0
CDC27	5348.0
CENPK	5388.0
NSL1	5459.0
TUBA4A	5567.0
PDS5A	5596.0
ANAPC1	5774.0
ANAPC15	5844.0
CEP250	5926.0
H2BC14	6016.0
TUBA1A	6100.0
NUP43	6107.0
ARPP19	6160.0
ANAPC16	6225.0
H2BC1	6290.0
PSME1	6314.0
LPIN2	6336.0
H3C1	6458.0
PPP1CC	6592.0
CHMP6	6620.0
LPIN3	6693.0
UBE2E1	6712.0
PPP2CA	6732.0
CEP131	6826.0
TUBB4B	6910.0
H4C6	6913.0
CHMP2B	6950.0
MZT1	6960.0
TUBB6	7030.0
RCC2	7254.0
CENPM	7288.0
BUB1B	7699.0
TUBB1	7729.0
NUP210	7811.0
NUP62	7909.0
NEK6	8099.0
PMF1	8129.0
TUBGCP6	8154.0
SET	8189.0
CENPS	8690.0
TUBA3D	8852.0
GORASP2	8919.0
SEM1	9392.0
H2AC14	9915.0

---

REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS

REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS

	1282
set	REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS
setSize	121
pANOVA	9.19e-07
s.dist	-0.258
p.adjustANOVA	0.000302

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
H2BC9	-9375.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
PSMA7	-9072.0
H3C11	-9013.0
PSMD9	-8887.0
PSMA6	-8781.0
PSMB10	-8751.0
H2BC15	-8620.0
PSMC2	-8506.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
TCF12	-7906.0
PSMF1	-7828.0
TAL1	-7764.0
PSMB3	-7613.0
PSMA4	-6953.0
PSMB8	-6727.0
PSMB1	-6458.0
CDK7	-6225.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
H2AZ2	-5775.0
H2BC11	-5756.0
PSMD4	-5443.0
PSMB5	-5303.0
UBB	-5278.0
LDB1	-5103.0
PSMA3	-5040.0
H3C2	-4876.0
RUNX1	-4859.0
TCF3	-4833.0
MYB	-4476.0
MNAT1	-4434.0
PSMB7	-3196.0
PSMA1	-3041.0
H4C4	-2969.0
PSMC5	-2598.0
PSMD7	-2547.0
H4C11	-2506.0
LMO2	-2271.0
H2BC4	-2161.0
UBC	-2067.0
H2AC6	-2051.0
ITCH	-1877.0
H4C5	-1423.0
H3-3A	-1342.0
SPI1	-1209.0
CCNH	-1145.0
PSMB6	-1085.0
H2BC5	-999.0
PSMA5	-964.0
PSMB4	-949.0
PSMA2	-698.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
YAP1	-378.0
PSMD11	-47.0
PSME3	308.0
H4C3	423.0
PSMB9	675.0
PSMD5	1121.0
H4C16	1337.0
CBFB	1427.0
PSMD12	1518.0
ABL1	1646.0
H2AJ	1704.0
PSMD13	1814.0
H2BC3	1965.0
PSMC4	1992.0
H2BC21	2421.0
PSMD3	2572.0
PSMB2	2710.0
H2AZ1	2761.0
UBA52	2905.0
PSMC1	3545.0
PSME4	3824.0
H4C2	4419.0
PSME2	4493.0
KMT2A	4645.0
PSMA8	4885.0
H3C3	4893.0
H2AC20	5150.0
TP73	5955.0
H2BC14	6016.0
LMO1	6031.0
H2BC1	6290.0
PSME1	6314.0
H3C1	6458.0
H4C6	6913.0
GATA2	7123.0
SEM1	9392.0
H2AC14	9915.0

---

REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION

REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION

	1091
set	REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION
setSize	62
pANOVA	4.37e-06
s.dist	-0.337
p.adjustANOVA	0.000981

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
ORC1	-6900.0
ORC5	-6642.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
KPNB1	-5545.0
H3C2	-4876.0
KPNA6	-3185.0
H4C4	-2969.0
ORC4	-2672.0
ORC6	-2669.0
H4C11	-2506.0
KPNA1	-2173.0
H2BC4	-2161.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
H2BC12	-482.0
ORC2	-95.0
H4C3	423.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
ORC3	3240.0
H4C2	4419.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
H2AC14	9915.0

---

REACTOME_DNA_REPLICATION

REACTOME_DNA_REPLICATION

	1113
set	REACTOME_DNA_REPLICATION
setSize	178
pANOVA	4.76e-06
s.dist	-0.199
p.adjustANOVA	0.000981

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLE4	-10274.0
H3C4	-10062.0
GINS3	-9921.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
H2BC8	-9584.0
CCNE2	-9570.0
H2BC17	-9503.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLE4	-10274.0
H3C4	-10062.0
GINS3	-9921.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
H2BC8	-9584.0
CCNE2	-9570.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
PSMA7	-9072.0
H3C11	-9013.0
PSMD9	-8887.0
MCM4	-8837.0
PSMA6	-8781.0
PSMB10	-8751.0
H2BC15	-8620.0
PSMC2	-8506.0
RFC5	-8423.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
CDC7	-7868.0
PSMF1	-7828.0
PSMB3	-7613.0
POLD2	-7345.0
PRIM2	-7259.0
CCNE1	-7048.0
PSMA4	-6953.0
ORC1	-6900.0
SKP1	-6898.0
MCM8	-6772.0
PSMB8	-6727.0
ORC5	-6642.0
GINS1	-6555.0
PSMB1	-6458.0
LIG1	-6397.0
RFC4	-6357.0
ANAPC5	-6173.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
PRIM1	-5927.0
RPS27A	-5922.0
H2AZ2	-5775.0
H2BC11	-5756.0
RFC1	-5699.0
KPNB1	-5545.0
DBF4	-5544.0
PSMD4	-5443.0
PSMB5	-5303.0
UBB	-5278.0
POLA2	-5226.0
PSMA3	-5040.0
H3C2	-4876.0
CDC45	-4296.0
CCNA1	-4010.0
POLE3	-3713.0
GINS2	-3613.0
PSMB7	-3196.0
KPNA6	-3185.0
MCM3	-3095.0
ANAPC10	-3050.0
PSMA1	-3041.0
H4C4	-2969.0
ORC4	-2672.0
ORC6	-2669.0
PSMC5	-2598.0
PSMD7	-2547.0
H4C11	-2506.0
ANAPC11	-2468.0
UBE2D1	-2260.0
KPNA1	-2173.0
POLE	-2169.0
H2BC4	-2161.0
UBC	-2067.0
H2AC6	-2051.0
RFC3	-1900.0
ANAPC4	-1807.0
MCM6	-1605.0
H4C5	-1423.0
H3-3A	-1342.0
MCM10	-1302.0
DNA2	-1169.0
PSMB6	-1085.0
H2BC5	-999.0
PSMA5	-964.0
PSMB4	-949.0
PSMA2	-698.0
CDC16	-598.0
GINS4	-496.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
CDC6	-419.0
RPA3	-298.0
RBX1	-261.0
CDC26	-126.0
ORC2	-95.0
PSMD11	-47.0
PCNA	79.0
SKP2	169.0
CCNA2	268.0
PSME3	308.0
H4C3	423.0
CDT1	645.0
PSMB9	675.0
ANAPC7	838.0
POLD1	1119.0
PSMD5	1121.0
H4C16	1337.0
PSMD12	1518.0
MCM2	1539.0
CDC23	1666.0
H2AJ	1704.0
PSMD13	1814.0
CDK2	1892.0
H2BC3	1965.0
PSMC4	1992.0
RFC2	2285.0
H2BC21	2421.0
PSMD3	2572.0
PSMB2	2710.0
H2AZ1	2761.0
ANAPC2	2780.0
UBA52	2905.0
ORC3	3240.0
PSMC1	3545.0
POLD3	3753.0
PSME4	3824.0
H4C2	4419.0
PSME2	4493.0
FZR1	4599.0
PSMA8	4885.0
H3C3	4893.0
H2AC20	5150.0
CDC27	5348.0
POLD4	5396.0
ANAPC1	5774.0
ANAPC15	5844.0
H2BC14	6016.0
RPA1	6175.0
ANAPC16	6225.0
H2BC1	6290.0
PSME1	6314.0
H3C1	6458.0
CUL1	6606.0
UBE2E1	6712.0
H4C6	6913.0
MCM7	7817.0
FEN1	7913.0
GMNN	7984.0
SEM1	9392.0
RPA2	9677.0
H2AC14	9915.0
MCM5	10021.0
POLE2	10051.0

---

REACTOME_MEIOTIC_RECOMBINATION

REACTOME_MEIOTIC_RECOMBINATION

	1433
set	REACTOME_MEIOTIC_RECOMBINATION
setSize	80
pANOVA	4.78e-06
s.dist	-0.296
p.adjustANOVA	0.000981

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TEX15	-10877.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
TOP3A	-9928.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TEX15	-10877.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
TOP3A	-9928.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
BRCA1	-9099.0
H3C11	-9013.0
MSH4	-8868.0
MRE11	-8696.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
RBBP8	-7671.0
CDK4	-7529.0
ATM	-7508.0
BRCA2	-7328.0
MLH1	-6596.0
RAD51	-6165.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
MLH3	-5618.0
H3C2	-4876.0
SPO11	-4713.0
NBN	-4575.0
BLM	-3594.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
MND1	-1870.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
H2BC12	-482.0
RPA3	-298.0
H4C3	423.0
PSMC3IP	1060.0
RAD50	1099.0
H4C16	1337.0
H2AJ	1704.0
CDK2	1892.0
H2BC3	1965.0
H3-4	2321.0
MSH5	2404.0
H2BC21	2421.0
H2AZ1	2761.0
H4C2	4419.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
RPA1	6175.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
DMC1	6937.0
RAD51C	7987.0
PRDM9	8445.0
RPA2	9677.0
H2AC14	9915.0

---

REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

	1082
set	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
setSize	125
pANOVA	5.73e-06
s.dist	0.235
p.adjustANOVA	0.00105

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRT72	10550
SPRR2E	10471
KRT14	10405
LIPN	10355
LCE2B	10325
KRT38	10315
KRT13	10264
KRT4	10023
KRT83	9983
KRT6B	9911
KRT78	9820
KRT79	9727
KRT86	9682
KRT80	9678
KRT2	9537
KRT24	9367
CELA2A	9331
SPRR1B	9264
KRT74	9057
SPINK6	9038

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRT72	10550
SPRR2E	10471
KRT14	10405
LIPN	10355
LCE2B	10325
KRT38	10315
KRT13	10264
KRT4	10023
KRT83	9983
KRT6B	9911
KRT78	9820
KRT79	9727
KRT86	9682
KRT80	9678
KRT2	9537
KRT24	9367
CELA2A	9331
SPRR1B	9264
KRT74	9057
SPINK6	9038
LCE6A	9034
KLK14	8967
KRT3	8913
LIPK	8854
PKP1	8839
SPRR3	8713
KRT6A	8602
KRT73	8248
KRT18	8217
TCHH	8090
KRT25	8068
PRSS8	7877
KRT40	7759
CDSN	7750
LCE2C	7702
KRT82	7466
PKP3	7441
TGM1	7395
KLK13	7244
KRT36	6627
KRT33A	6618
CSTA	6608
KRT7	6541
KRT81	6424
LCE1C	6186
KRT23	6084
EVPL	6052
LCE5A	5827
LCE1F	5696
DSC1	5683
LCE3A	5518
LELP1	5435
SPINK5	5320
KLK5	5268
KRT19	5145
LCE2D	5082
DSG2	5002
KAZN	4986
KRT75	4909
PCSK6	4864
LCE1E	4489
RPTN	4449
KRT15	4357
KRT17	4302
PPL	4122
KRT28	4046
KRT77	3979
KRT8	3767
LCE1B	3730
KRT71	3417
LCE1A	2636
KRT32	2557
DSG3	2373
PKP2	2310
KRT34	2018
LCE3E	1948
CAPN1	1832
PI3	1030
KLK8	993
JUP	492
SPINK9	420
KRT20	322
ST14	203
DSG4	108
KRT26	13
KRT27	-159
IVL	-812
PKP4	-852
SPRR2A	-1275
KRT6C	-1515
KLK12	-2062
SPRR2D	-2997
SPRR1A	-3276
DSP	-3441
LIPM	-3466
FURIN	-3491
LIPJ	-3968
CAPNS1	-4078
PERP	-4437
KRT12	-5161
KRT85	-5434
KRT10	-5539
KRT5	-5660
SPRR2F	-5830
KRT33B	-6359
KRT1	-6379
KRT9	-6600
FLG	-6893
KRT39	-7535
LCE3B	-8050
LCE2A	-8472
KRT84	-8618
KRT37	-8836
SPRR2G	-9031
KRT31	-9188
LCE4A	-9396
CASP14	-9605
DSC3	-9829
KRT76	-10430
TGM5	-10823
KRT35	-10886
DSC2	-10901
DSG1	-10935
LCE3D	-11055
KRT16	-11331

---

REACTOME_CELL_CYCLE_CHECKPOINTS

REACTOME_CELL_CYCLE_CHECKPOINTS

	1120
set	REACTOME_CELL_CYCLE_CHECKPOINTS
setSize	284
pANOVA	1e-05
s.dist	-0.152
p.adjustANOVA	0.00151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2BC7	-10629.5
RHNO1	-10392.0
ZWINT	-10230.0
YWHAB	-10128.0
NUP85	-10122.0
PCBP4	-10096.0
DYNLL1	-10008.0
CENPE	-9941.0
TOP3A	-9928.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
PSMC6	-9675.0
SPC24	-9653.0
H2BC8	-9584.0
CCNE2	-9570.0
H2BC17	-9503.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2BC7	-10629.5
RHNO1	-10392.0
ZWINT	-10230.0
YWHAB	-10128.0
NUP85	-10122.0
PCBP4	-10096.0
DYNLL1	-10008.0
CENPE	-9941.0
TOP3A	-9928.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
PSMC6	-9675.0
SPC24	-9653.0
H2BC8	-9584.0
CCNE2	-9570.0
H2BC17	-9503.0
PSMD14	-9466.0
UBE2C	-9436.0
H2BC9	-9375.5
YWHAQ	-9275.0
PSMC3	-9217.0
XPO1	-9161.0
BRCA1	-9099.0
PSMA7	-9072.0
MIS12	-8977.0
DYNLL2	-8918.0
BIRC5	-8888.0
PSMD9	-8887.0
MCM4	-8837.0
PSMA6	-8781.0
PSMB10	-8751.0
MRE11	-8696.0
H2BC15	-8620.0
PSMC2	-8506.0
RFC5	-8423.0
PSMB11	-8322.0
H2AX	-8295.0
CDKN2A	-8076.0
H4C13	-7923.0
CDC7	-7868.0
PSMF1	-7828.0
RBBP8	-7671.0
PSMB3	-7613.0
SPC25	-7594.0
WEE1	-7583.0
BUB1	-7509.0
ATM	-7508.0
SKA1	-7499.0
ATRIP	-7443.0
UBE2V2	-7378.0
TOPBP1	-7343.0
KIF2B	-7174.0
CCNE1	-7048.0
CENPA	-7025.0
PSMA4	-6953.0
ZNF385A	-6942.0
ORC1	-6900.0
CENPF	-6868.0
MCM8	-6772.0
MDM2	-6733.0
PSMB8	-6727.0
SGO2	-6645.0
ORC5	-6642.0
BABAM2	-6564.0
KNL1	-6549.0
PSMB1	-6458.0
MAD2L1	-6363.0
RFC4	-6357.0
PPP2R1B	-6311.0
PPP2R5B	-6192.0
ANAPC5	-6173.0
H4C8	-5994.0
PPP2R5D	-5981.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
YWHAH	-5939.0
RPS27A	-5922.0
NUP107	-5851.0
H2BC11	-5756.0
DBF4	-5544.0
NDC80	-5484.0
PSMD4	-5443.0
DYNC1LI1	-5413.0
CHEK1	-5363.0
PSMB5	-5303.0
UBB	-5278.0
SGO1	-5198.0
NUDC	-5184.0
CCNB1	-5146.0
COP1	-5111.0
PSMA3	-5040.0
CENPP	-4981.0
KIF2A	-4900.0
NUP160	-4777.0
NBN	-4575.0
ATR	-4504.0
CLASP2	-4463.0
CDC45	-4296.0
PPP2R1A	-4275.0
MAD1L1	-4226.0
RANBP2	-4186.0
KIF2C	-4164.0
NUP37	-4123.0
SEC13	-4109.0
CCNA1	-4010.0
MAPRE1	-4007.0
BARD1	-3957.0
TP53	-3947.0
NUP98	-3940.0
SPDL1	-3860.0
ZWILCH	-3655.0
CENPL	-3607.0
BLM	-3594.0
RMI2	-3522.0
BRIP1	-3490.0
WRN	-3454.0
SKA2	-3415.0
INCENP	-3300.0
PSMB7	-3196.0
DYNC1I1	-3186.0
MCM3	-3095.0
ANAPC10	-3050.0
PSMA1	-3041.0
H4C4	-2969.0
RAD17	-2958.0
TP53BP1	-2701.0
ORC4	-2672.0
ORC6	-2669.0
PSMC5	-2598.0
PSMD7	-2547.0
H4C11	-2506.0
CENPQ	-2491.0
ANAPC11	-2468.0
MDC1	-2451.0
KIF18A	-2373.0
UBE2D1	-2260.0
H2BC4	-2161.0
YWHAZ	-2100.0
UBC	-2067.0
UBE2N	-2050.0
NDEL1	-2044.0
CLSPN	-1972.0
DYNC1LI2	-1905.0
CENPC	-1901.0
RFC3	-1900.0
RMI1	-1872.0
PPP2R5C	-1840.0
ANAPC4	-1807.0
MCM6	-1605.0
H4C5	-1423.0
MCM10	-1302.0
HUS1	-1217.0
PAFAH1B1	-1210.0
DNA2	-1169.0
RANGAP1	-1144.0
PSMB6	-1085.0
B9D2	-1005.0
H2BC5	-999.0
RNF8	-986.0
UIMC1	-983.0
PSMA5	-964.0
PSMB4	-949.0
CCNB2	-898.0
CDC25A	-853.0
YWHAG	-766.0
PSMA2	-698.0
KNTC1	-667.0
DSN1	-642.0
PPP2R5E	-634.0
CDC16	-598.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
CDC6	-419.0
RPA3	-298.0
NSD2	-283.0
ITGB3BP	-255.0
CDC26	-126.0
ORC2	-95.0
PSMD11	-47.0
CDKN1A	1.0
CLASP1	104.0
CDC20	243.0
CCNA2	268.0
PSME3	308.0
H4C3	423.0
CDK1	604.0
PSMB9	675.0
CENPU	759.0
ANAPC7	838.0
PPP2R5A	866.0
CLIP1	884.0
CKAP5	1008.0
RAD50	1099.0
CENPN	1116.0
PSMD5	1121.0
CDC25C	1212.0
AHCTF1	1236.0
H4C16	1337.0
HERC2	1352.0
PSMD12	1518.0
MCM2	1539.0
CDC23	1666.0
NUP133	1721.0
PSMD13	1814.0
YWHAE	1817.0
CDK2	1892.0
H2BC3	1965.0
PSMC4	1992.0
CENPT	2001.0
RFC2	2285.0
H3-4	2321.0
CENPO	2415.0
H2BC21	2421.0
PHF20	2500.0
NUF2	2503.0
PSMD3	2572.0
NDE1	2582.0
PIAS4	2600.0
RAD1	2602.0
SEH1L	2648.0
CDCA8	2698.0
PSMB2	2710.0
ANAPC2	2780.0
UBA52	2905.0
ORC3	3240.0
DYNC1I2	3247.0
TAOK1	3350.0
PLK1	3423.0
CENPH	3473.0
RAD9A	3485.0
PSMC1	3545.0
EXO1	3564.0
DYNC1H1	3577.0
BUB3	3598.0
CDKN1B	3615.0
PSME4	3824.0
H4C2	4419.0
ZW10	4480.0
PSME2	4493.0
RPS27	4496.0
PPP2CB	4668.0
PSMA8	4885.0
RAD9B	4895.0
BABAM1	4984.0
GTSE1	4995.0
CHEK2	5010.0
AURKB	5224.0
CDC27	5348.0
CENPK	5388.0
NSL1	5459.0
ANAPC1	5774.0
ANAPC15	5844.0
H2BC14	6016.0
NUP43	6107.0
RPA1	6175.0
ANAPC16	6225.0
H2BC1	6290.0
PSME1	6314.0
RNF168	6513.0
PPP1CC	6592.0
UBE2E1	6712.0
PPP2CA	6732.0
H4C6	6913.0
RCC2	7254.0
CENPM	7288.0
ABRAXAS1	7405.0
KAT5	7650.0
BUB1B	7699.0
MCM7	7817.0
PKMYT1	7970.0
PMF1	8129.0
CENPS	8690.0
SEM1	9392.0
RPA2	9677.0
SFN	9832.0
MDM4	10012.0
MCM5	10021.0

---

REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

	1395
set	REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION
setSize	140
pANOVA	1.22e-05
s.dist	-0.214
p.adjustANOVA	0.00151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
PGR	-10303.0
H3C4	-10062.0
FOXA1	-9911.0
H4C9	-9887.0
H4C12	-9845.0
CTSD	-9727.0
H2AC8	-9679.0
FKBP4	-9610.0
H2BC8	-9584.0
NRIP1	-9567.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
PGR	-10303.0
H3C4	-10062.0
FOXA1	-9911.0
H4C9	-9887.0
H4C12	-9845.0
CTSD	-9727.0
H2AC8	-9679.0
FKBP4	-9610.0
H2BC8	-9584.0
NRIP1	-9567.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
GTF2F1	-8995.0
YY1	-8801.0
GTF2A1	-8765.0
H2BC15	-8620.0
NCOA1	-8514.0
H2AX	-8295.0
EBAG9	-8292.0
H3-3B	-8282.0
GTF2A2	-8087.0
CXCL12	-8045.0
H4C13	-7923.0
H3C6	-7918.0
HSP90AA1	-6752.0
FOS	-6639.0
NR5A2	-6389.0
DDX5	-6380.0
ERBB4	-6250.0
KCTD6	-6190.0
POLR2G	-6150.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
CCNT1	-5531.0
TNRC6B	-5455.0
GPAM	-5201.0
H3C2	-4876.0
RUNX1	-4859.0
KAT2B	-4853.0
POLR2H	-4815.0
SMC3	-4651.0
SP1	-4636.0
MYB	-4476.0
TGFA	-4134.0
POLR2L	-4064.0
MOV10	-4030.0
GTF2F2	-4002.0
PRMT1	-3642.0
TNRC6A	-3455.0
MED1	-3348.0
HDAC1	-3246.0
NCOA3	-3134.0
POLR2I	-2974.0
H4C4	-2969.0
H4C11	-2506.0
NCOA2	-2193.0
H2BC4	-2161.0
AGO2	-2087.0
H2AC6	-2051.0
FOSB	-1684.0
POU2F1	-1664.0
PTGES3	-1522.0
EP300	-1428.0
STAG1	-1424.0
H4C5	-1423.0
CARM1	-1419.0
H3-3A	-1342.0
HSP90AB1	-1174.0
BCL2	-1166.0
POLR2F	-1161.0
H2BC5	-999.0
KDM4B	-876.0
TLE3	-833.0
POLR2A	-696.0
JUN	-686.0
AXIN1	-582.0
H2BC12	-482.0
ESR1	-109.0
CDK9	48.0
USF2	218.0
USF1	385.0
H4C3	423.0
TBP	561.0
AGO3	957.0
H4C16	1337.0
CBFB	1427.0
MYC	1474.0
AGO4	1527.0
ATF2	1544.0
KDM1A	1556.0
H2AJ	1704.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
POLR2B	2810.0
CCND1	2977.0
KPNA2	3395.0
JUND	3587.0
RAD21	3920.0
POLR2J	4123.0
CREBBP	4132.0
CXXC5	4203.0
TNRC6C	4348.0
H4C2	4419.0
POLR2C	4579.0
H3C3	4893.0
H2AC20	5150.0
KANK1	5411.0
CHD1	5763.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
POLR2D	6966.0
GREB1	7239.0
TFF3	7520.0
KAT5	7650.0
TFF1	8627.0
ZNF217	9736.0
H2AC14	9915.0
AGO1	10289.0

---

REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE

REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE

	501
set	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE
setSize	118
pANOVA	1.23e-05
s.dist	-0.233
p.adjustANOVA	0.00151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MIR24-2	-10989.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
E2F1	-10358.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
TFDP1	-9800.0
CBX8	-9733.0
H2AC8	-9679.0
CBX4	-9601.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MIR24-2	-10989.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
E2F1	-10358.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
TFDP1	-9800.0
CBX8	-9733.0
H2AC8	-9679.0
CBX4	-9601.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
CDKN2B	-9096.0
TXN	-9040.0
H3C11	-9013.0
MAPKAPK5	-8927.0
H2BC15	-8620.0
MAP2K4	-8500.0
H2AX	-8295.0
H3-3B	-8282.0
CDKN2A	-8076.0
H4C13	-7923.0
H3C6	-7918.0
MAPK3	-7607.0
CDK4	-7529.0
MAP3K5	-7175.0
EZH2	-6787.0
MDM2	-6733.0
E2F2	-6669.0
MAPK8	-6659.0
FOS	-6639.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
H2AZ2	-5775.0
RING1	-5768.0
E2F3	-5757.0
H2BC11	-5756.0
TNRC6B	-5455.0
UBB	-5278.0
H3C2	-4876.0
SCMH1	-4488.0
KDM6B	-4338.0
PHC3	-4300.0
MOV10	-4030.0
TP53	-3947.0
CBX2	-3609.0
TNRC6A	-3455.0
TFDP2	-3304.0
RBBP4	-3061.0
MAPK14	-3056.0
H4C4	-2969.0
MINK1	-2938.0
H4C11	-2506.0
H2BC4	-2161.0
UBC	-2067.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
MAP2K7	-1008.0
H2BC5	-999.0
EED	-862.0
JUN	-686.0
H2BC12	-482.0
MAPK11	20.0
SUZ12	106.0
H4C3	423.0
MAP2K6	747.0
CDK6	783.0
PHC2	864.0
AGO3	957.0
MAPKAPK3	1077.0
H4C16	1337.0
BMI1	1398.0
AGO4	1527.0
PHC1	1550.0
MAPK1	1551.0
H2AJ	1704.0
MAPK9	1762.0
H2BC3	1965.0
H2BC21	2421.0
RNF2	2733.0
H2AZ1	2761.0
UBA52	2905.0
TNRC6C	4348.0
H4C2	4419.0
TNIK	4606.0
CDKN2C	4767.0
H3C3	4893.0
MAP2K3	5017.0
CBX6	5032.0
MAP4K4	5044.0
H2AC20	5150.0
MAPKAPK2	5464.0
H2BC14	6016.0
MAPK10	6096.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
MIR24-1	7107.0
IFNB1	9714.0
H2AC14	9915.0
MDM4	10012.0
CDKN2D	10040.0
AGO1	10289.0

---

REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES

REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES

	480
set	REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES
setSize	66
pANOVA	1.28e-05
s.dist	-0.311
p.adjustANOVA	0.00151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
RB1	-10297.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
SMC4	-9624.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
RB1	-10297.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
SMC4	-9624.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
SMC2	-5782.0
H2AZ2	-5775.0
H2BC11	-5756.0
MCPH1	-5392.0
CCNB1	-5146.0
H3C2	-4876.0
NCAPG2	-3067.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
NCAPD3	-911.0
H2BC12	-482.0
H4C3	423.0
CDK1	604.0
KMT5A	861.0
H4C16	1337.0
NCAPH2	1353.0
H2AJ	1704.0
H2BC3	1965.0
H3-4	2321.0
H2BC21	2421.0
H2AZ1	2761.0
PLK1	3423.0
H4C2	4419.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
SET	8189.0
H2AC14	9915.0

---

REACTOME_DNA_REPLICATION_PRE_INITIATION

REACTOME_DNA_REPLICATION_PRE_INITIATION

	1101
set	REACTOME_DNA_REPLICATION_PRE_INITIATION
setSize	150
pANOVA	1.28e-05
s.dist	-0.206
p.adjustANOVA	0.00151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLE4	-10274.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLE4	-10274.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
PSMA7	-9072.0
H3C11	-9013.0
PSMD9	-8887.0
MCM4	-8837.0
PSMA6	-8781.0
PSMB10	-8751.0
H2BC15	-8620.0
PSMC2	-8506.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
CDC7	-7868.0
PSMF1	-7828.0
PSMB3	-7613.0
PRIM2	-7259.0
PSMA4	-6953.0
ORC1	-6900.0
MCM8	-6772.0
PSMB8	-6727.0
ORC5	-6642.0
PSMB1	-6458.0
ANAPC5	-6173.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
PRIM1	-5927.0
RPS27A	-5922.0
H2AZ2	-5775.0
H2BC11	-5756.0
KPNB1	-5545.0
DBF4	-5544.0
PSMD4	-5443.0
PSMB5	-5303.0
UBB	-5278.0
POLA2	-5226.0
PSMA3	-5040.0
H3C2	-4876.0
CDC45	-4296.0
POLE3	-3713.0
PSMB7	-3196.0
KPNA6	-3185.0
MCM3	-3095.0
ANAPC10	-3050.0
PSMA1	-3041.0
H4C4	-2969.0
ORC4	-2672.0
ORC6	-2669.0
PSMC5	-2598.0
PSMD7	-2547.0
H4C11	-2506.0
ANAPC11	-2468.0
UBE2D1	-2260.0
KPNA1	-2173.0
POLE	-2169.0
H2BC4	-2161.0
UBC	-2067.0
H2AC6	-2051.0
ANAPC4	-1807.0
MCM6	-1605.0
H4C5	-1423.0
H3-3A	-1342.0
MCM10	-1302.0
PSMB6	-1085.0
H2BC5	-999.0
PSMA5	-964.0
PSMB4	-949.0
PSMA2	-698.0
CDC16	-598.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
CDC6	-419.0
RPA3	-298.0
CDC26	-126.0
ORC2	-95.0
PSMD11	-47.0
PSME3	308.0
H4C3	423.0
CDT1	645.0
PSMB9	675.0
ANAPC7	838.0
PSMD5	1121.0
H4C16	1337.0
PSMD12	1518.0
MCM2	1539.0
CDC23	1666.0
H2AJ	1704.0
PSMD13	1814.0
CDK2	1892.0
H2BC3	1965.0
PSMC4	1992.0
H2BC21	2421.0
PSMD3	2572.0
PSMB2	2710.0
H2AZ1	2761.0
ANAPC2	2780.0
UBA52	2905.0
ORC3	3240.0
PSMC1	3545.0
H4C2	4419.0
PSME2	4493.0
FZR1	4599.0
H3C3	4893.0
H2AC20	5150.0
CDC27	5348.0
ANAPC1	5774.0
ANAPC15	5844.0
H2BC14	6016.0
RPA1	6175.0
ANAPC16	6225.0
H2BC1	6290.0
PSME1	6314.0
H3C1	6458.0
UBE2E1	6712.0
H4C6	6913.0
MCM7	7817.0
GMNN	7984.0
SEM1	9392.0
RPA2	9677.0
H2AC14	9915.0
MCM5	10021.0
POLE2	10051.0

---

REACTOME_DNA_METHYLATION

REACTOME_DNA_METHYLATION

	858
set	REACTOME_DNA_METHYLATION
setSize	58
pANOVA	1.45e-05
s.dist	-0.329
p.adjustANOVA	0.00157

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
UHRF1	-9253.0
H3C11	-9013.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
UHRF1	-9253.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
DNMT1	-5876.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
DNMT3A	-3540.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
H2BC12	-482.0
H4C3	423.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
DNMT3B	3986.0
H4C2	4419.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
DNMT3L	9357.0
H2AC14	9915.0

---

REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION

REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION

	852
set	REACTOME_B_WICH_COMPLEX_POSITIVELY_REGULATES_RRNA_EXPRESSION
setSize	84
pANOVA	1.6e-05
s.dist	-0.272
p.adjustANOVA	0.00157

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
POLR1E	-7855.0
POLR1B	-7397.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
SMARCA5	-5263.0
H3C2	-4876.0
KAT2B	-4853.0
POLR2H	-4815.0
POLR1G	-4538.0
POLR1D	-4307.0
POLR2L	-4064.0
GSK3B	-4058.0
POLR1C	-3745.0
ACTB	-3090.0
H4C4	-2969.0
DEK	-2635.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
BAZ1B	-1820.0
DDX21	-1785.0
ERCC6	-1695.0
EP300	-1428.0
H4C5	-1423.0
H3-3A	-1342.0
POLR1H	-1267.0
POLR2F	-1161.0
MYBBP1A	-1095.0
H2BC5	-999.0
H2BC12	-482.0
MYO1C	-267.0
H4C3	423.0
TAF1A	554.0
TBP	561.0
H4C16	1337.0
SF3B1	1485.0
H2AJ	1704.0
H2BC3	1965.0
TAF1C	2010.0
H2BC21	2421.0
POLR1F	2760.0
H2AZ1	2761.0
TAF1B	3685.0
H4C2	4419.0
POLR1A	4622.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
KAT2A	8790.0
H2AC14	9915.0

---

REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA

REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA

	440
set	REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA
setSize	65
pANOVA	1.62e-05
s.dist	-0.309
p.adjustANOVA	0.00157

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
EZH2	-6787.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
DNMT1	-5876.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
DNMT3A	-3540.0
JARID2	-3082.0
RBBP4	-3061.0
H4C4	-2969.0
MTF2	-2900.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
PHF19	-867.0
EED	-862.0
H2BC12	-482.0
SUZ12	106.0
H4C3	423.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
PHF1	1976.0
AEBP2	2137.0
H2BC21	2421.0
H2AZ1	2761.0
DNMT3B	3986.0
H4C2	4419.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
H2AC14	9915.0

---

REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE

REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE

	1157
set	REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE
setSize	83
pANOVA	1.92e-05
s.dist	-0.271
p.adjustANOVA	0.00176

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0
H3C11	-9013.0
H2BC15	-8620.0
RRN3	-8589.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
POLR1E	-7855.0
ERCC3	-7795.0
POLR1B	-7397.0
CDK7	-6225.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
CBX3	-5783.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
POLR2H	-4815.0
GTF2H5	-4812.0
POLR1G	-4538.0
MNAT1	-4434.0
POLR1D	-4307.0
POLR2L	-4064.0
POLR1C	-3745.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
POLR1H	-1267.0
POLR2F	-1161.0
CCNH	-1145.0
H2BC5	-999.0
H2BC12	-482.0
GTF2H1	-188.0
H4C3	423.0
TAF1A	554.0
TBP	561.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
TAF1C	2010.0
H2BC21	2421.0
POLR1F	2760.0
H2AZ1	2761.0
TAF1B	3685.0
H4C2	4419.0
GTF2H4	4615.0
POLR1A	4622.0
H3C3	4893.0
H2AC20	5150.0
GTF2H3	5292.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
ERCC2	7598.0
UBTF	7947.0
H2AC14	9915.0

---

REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION

REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION

	737
set	REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION
setSize	60
pANOVA	2.46e-05
s.dist	-0.315
p.adjustANOVA	0.00213

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0
H3C11	-9013.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
RRP8	-2160.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
H2BC12	-482.0
H4C3	423.0
TAF1A	554.0
TBP	561.0
SIRT1	613.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
TAF1C	2010.0
H2BC21	2421.0
H2AZ1	2761.0
TAF1B	3685.0
H4C2	4419.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
H2AC14	9915.0

---

REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3

REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3

	916
set	REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3
setSize	59
pANOVA	2.74e-05
s.dist	-0.316
p.adjustANOVA	0.00223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
KDM4C	-6407.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
KLK3	-4993.0
H3C2	-4876.0
H4C4	-2969.0
H4C11	-2506.0
NCOA2	-2193.0
H2BC4	-2161.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
H2BC12	-482.0
H4C3	423.0
H4C16	1337.0
KDM1A	1556.0
H2AJ	1704.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
H4C2	4419.0
H3C3	4893.0
KLK2	4985.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
PKN1	6503.0
H4C6	6913.0
H2AC14	9915.0

---

REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS

REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS

	1476
set	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS
setSize	83
pANOVA	2.86e-05
s.dist	-0.266
p.adjustANOVA	0.00223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
E2F1	-10358.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
TFDP1	-9800.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
E2F1	-10358.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
TFDP1	-9800.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
CEBPA	-7939.0
H4C13	-7923.0
H3C6	-7918.0
CEBPE	-7809.0
TAL1	-7764.0
CDK4	-7529.0
CSF3R	-6546.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
KLF5	-5910.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
RUNX1	-4859.0
MYB	-4476.0
CEBPB	-4430.0
TFDP2	-3304.0
H4C4	-2969.0
GFI1	-2763.0
DEK	-2635.0
H4C11	-2506.0
H2BC4	-2161.0
RXRA	-2115.0
H2AC6	-2051.0
EP300	-1428.0
H4C5	-1423.0
H3-3A	-1342.0
SPI1	-1209.0
H2BC5	-999.0
H2BC12	-482.0
LEF1	-58.0
CDKN1A	1.0
H4C3	423.0
PML	823.0
H4C16	1337.0
CBFB	1427.0
MYC	1474.0
H2AJ	1704.0
CDK2	1892.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
RARA	2942.0
FLI1	4226.0
H4C2	4419.0
KMT2A	4645.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
IL6R	6346.0
H3C1	6458.0
CREB1	6597.0
H4C6	6913.0
GATA2	7123.0
STAT3	7142.0
H2AC14	9915.0

---

REACTOME_CELLULAR_SENESCENCE

REACTOME_CELLULAR_SENESCENCE

	503
set	REACTOME_CELLULAR_SENESCENCE
setSize	189
pANOVA	3.19e-05
s.dist	-0.175
p.adjustANOVA	0.00238

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MIR24-2	-10989.0
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
E2F1	-10358.0
RB1	-10297.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
HMGA1	-9808.0
TFDP1	-9800.0
CBX8	-9733.0
H2AC8	-9679.0
CBX4	-9601.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MIR24-2	-10989.0
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
E2F1	-10358.0
RB1	-10297.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
HMGA1	-9808.0
TFDP1	-9800.0
CBX8	-9733.0
H2AC8	-9679.0
CBX4	-9601.0
H2BC8	-9584.0
CCNE2	-9570.0
H2BC17	-9503.0
H3C10	-9467.0
UBE2C	-9436.0
ETS2	-9400.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
CDKN2B	-9096.0
TXN	-9040.0
H3C11	-9013.0
MAPKAPK5	-8927.0
ERF	-8782.0
MRE11	-8696.0
H2BC15	-8620.0
MAP2K4	-8500.0
H2AX	-8295.0
H3-3B	-8282.0
CDKN2A	-8076.0
MAPK7	-7934.0
H4C13	-7923.0
H3C6	-7918.0
UBN1	-7634.0
MAPK3	-7607.0
CDK4	-7529.0
ATM	-7508.0
MAP3K5	-7175.0
TERF2IP	-7165.0
CCNE1	-7048.0
EZH2	-6787.0
MDM2	-6733.0
E2F2	-6669.0
CABIN1	-6663.0
MAPK8	-6659.0
FOS	-6639.0
TINF2	-6451.0
RPS6KA1	-6373.0
ANAPC5	-6173.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
TERF2	-5913.0
H2AZ2	-5775.0
RING1	-5768.0
E2F3	-5757.0
H2BC11	-5756.0
TNRC6B	-5455.0
UBB	-5278.0
H3C2	-4876.0
RPS6KA2	-4871.0
SP1	-4636.0
NBN	-4575.0
SCMH1	-4488.0
CEBPB	-4430.0
KDM6B	-4338.0
PHC3	-4300.0
MOV10	-4030.0
CCNA1	-4010.0
TP53	-3947.0
H1-3	-3670.0
IGFBP7	-3651.0
NFKB1	-3646.0
CBX2	-3609.0
TNRC6A	-3455.0
TFDP2	-3304.0
RBBP4	-3061.0
MAPK14	-3056.0
ANAPC10	-3050.0
H4C4	-2969.0
MINK1	-2938.0
H1-2	-2683.0
H4C11	-2506.0
ANAPC11	-2468.0
UBE2D1	-2260.0
ETS1	-2206.0
H2BC4	-2161.0
EHMT2	-2146.0
UBC	-2067.0
H2AC6	-2051.0
ANAPC4	-1807.0
HIRA	-1482.0
H4C5	-1423.0
H3-3A	-1342.0
MAP2K7	-1008.0
H2BC5	-999.0
EED	-862.0
JUN	-686.0
EHMT1	-638.0
CXCL8	-621.0
CDC16	-598.0
H2BC12	-482.0
IL1A	-391.0
POT1	-227.0
CDC26	-126.0
CDKN1A	1.0
MAPK11	20.0
IL6	43.0
SUZ12	106.0
H1-4	209.0
CCNA2	268.0
EP400	406.0
H4C3	423.0
ID1	591.0
MAP2K6	747.0
CDK6	783.0
ANAPC7	838.0
PHC2	864.0
AGO3	957.0
MAPKAPK3	1077.0
RAD50	1099.0
H4C16	1337.0
RELA	1384.0
BMI1	1398.0
AGO4	1527.0
PHC1	1550.0
MAPK1	1551.0
CDC23	1666.0
H2AJ	1704.0
MAPK9	1762.0
LMNB1	1840.0
CDK2	1892.0
TERF1	1919.0
H2BC3	1965.0
ACD	2104.5
H3-4	2321.0
H2BC21	2421.0
RNF2	2733.0
H2AZ1	2761.0
ANAPC2	2780.0
UBA52	2905.0
CDKN1B	3615.0
H1-5	4081.0
TNRC6C	4348.0
H4C2	4419.0
FZR1	4599.0
TNIK	4606.0
CDKN2C	4767.0
H3C3	4893.0
MAP2K3	5017.0
CBX6	5032.0
MAP4K4	5044.0
HMGA2	5071.0
H2AC20	5150.0
CDC27	5348.0
MAPKAPK2	5464.0
ANAPC1	5774.0
ANAPC15	5844.0
H2BC14	6016.0
MAPK10	6096.0
ANAPC16	6225.0
H2BC1	6290.0
H3C1	6458.0
UBE2E1	6712.0
H4C6	6913.0
MIR24-1	7107.0
STAT3	7142.0
H1-0	7164.0
KAT5	7650.0
ASF1A	7787.0
VENTX	8480.0
H1-1	9460.0
IFNB1	9714.0
H2AC14	9915.0
MDM4	10012.0
CDKN2D	10040.0
AGO1	10289.0

---

REACTOME_ESR_MEDIATED_SIGNALING

REACTOME_ESR_MEDIATED_SIGNALING

	1281
set	REACTOME_ESR_MEDIATED_SIGNALING
setSize	210
pANOVA	3.96e-05
s.dist	-0.165
p.adjustANOVA	0.00283

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NRAS	-11029.0
MMP9	-10883.0
H2BC13	-10817.0
GNAI1	-10788.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
PGR	-10303.0
GNG8	-10248.0
H3C4	-10062.0
GNGT1	-10012.0
GNG10	-10006.0
FOXA1	-9911.0
H4C9	-9887.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NRAS	-11029.0
MMP9	-10883.0
H2BC13	-10817.0
GNAI1	-10788.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
PGR	-10303.0
GNG8	-10248.0
H3C4	-10062.0
GNGT1	-10012.0
GNG10	-10006.0
FOXA1	-9911.0
H4C9	-9887.0
H4C12	-9845.0
CTSD	-9727.0
H2AC8	-9679.0
FKBP4	-9610.0
GNG11	-9609.0
H2BC8	-9584.0
NRIP1	-9567.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
XPO1	-9161.0
MMP2	-9092.0
H3C11	-9013.0
GTF2F1	-8995.0
YY1	-8801.0
GTF2A1	-8765.0
H2BC15	-8620.0
NCOA1	-8514.0
BTC	-8332.0
H2AX	-8295.0
EBAG9	-8292.0
H3-3B	-8282.0
GNAI3	-8276.0
GTF2A2	-8087.0
CXCL12	-8045.0
GNG4	-8043.0
H4C13	-7923.0
H3C6	-7918.0
MAPK3	-7607.0
ZDHHC21	-7455.0
HBEGF	-7429.0
KRAS	-7071.0
HSP90AA1	-6752.0
GNG2	-6750.0
FOS	-6639.0
NR5A2	-6389.0
DDX5	-6380.0
GNB4	-6331.0
ERBB4	-6250.0
GNB2	-6210.0
KCTD6	-6190.0
GNAT3	-6176.0
POLR2G	-6150.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
PIK3R1	-5723.0
PIK3CA	-5572.0
CCNT1	-5531.0
TNRC6B	-5455.0
EREG	-5261.0
GPAM	-5201.0
H3C2	-4876.0
RUNX1	-4859.0
KAT2B	-4853.0
POLR2H	-4815.0
CALM1	-4778.0
SMC3	-4651.0
SP1	-4636.0
STRN	-4549.0
MYB	-4476.0
TGFA	-4134.0
GNG12	-4121.0
POLR2L	-4064.0
MOV10	-4030.0
GTF2F2	-4002.0
PRMT1	-3642.0
TNRC6A	-3455.0
MED1	-3348.0
HDAC1	-3246.0
NCOA3	-3134.0
CAV2	-3015.0
POLR2I	-2974.0
H4C4	-2969.0
H4C11	-2506.0
PDPK1	-2363.0
NCOA2	-2193.0
H2BC4	-2161.0
PTK2	-2119.0
AGO2	-2087.0
H2AC6	-2051.0
IGF1R	-1752.0
FOSB	-1684.0
POU2F1	-1664.0
GNG5	-1641.0
ESR2	-1612.0
PTGES3	-1522.0
EP300	-1428.0
STAG1	-1424.0
H4C5	-1423.0
CARM1	-1419.0
H3-3A	-1342.0
SHC1	-1314.0
HSP90AB1	-1174.0
BCL2	-1166.0
POLR2F	-1161.0
H2BC5	-999.0
PRKCZ	-960.0
NOS3	-925.0
KDM4B	-876.0
TLE3	-833.0
UHMK1	-788.0
POLR2A	-696.0
JUN	-686.0
AXIN1	-582.0
ZDHHC7	-555.0
H2BC12	-482.0
GNAI2	-343.0
AKT3	-289.0
SRC	-215.0
FOXO3	-113.0
ESR1	-109.0
CDK9	48.0
USF2	218.0
HRAS	379.0
USF1	385.0
H4C3	423.0
TBP	561.0
PPP5C	716.0
AGO3	957.0
EGFR	1128.0
H4C16	1337.0
CBFB	1427.0
MYC	1474.0
AGO4	1527.0
ATF2	1544.0
MAPK1	1551.0
KDM1A	1556.0
MMP3	1604.0
H2AJ	1704.0
H2BC3	1965.0
SPHK1	2003.0
MMP7	2259.0
GNG13	2411.0
H2BC21	2421.0
H2AZ1	2761.0
POLR2B	2810.0
CCND1	2977.0
FKBP5	3222.0
KPNA2	3395.0
JUND	3587.0
CDKN1B	3615.0
CAV1	3754.0
PIK3R3	3791.0
AKT2	3850.0
RAD21	3920.0
POLR2J	4123.0
CREBBP	4132.0
CXXC5	4203.0
TNRC6C	4348.0
H4C2	4419.0
POLR2C	4579.0
GNB1	4690.0
GNB5	4873.0
GNG7	4891.0
H3C3	4893.0
H2AC20	5150.0
KANK1	5411.0
AKT1	5667.0
CHD1	5763.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
S1PR3	6471.0
POLR2E	6530.0
CREB1	6597.0
EGF	6736.0
H4C6	6913.0
POLR2D	6966.0
HSPB1	7147.0
PPID	7150.0
GREB1	7239.0
SRF	7428.0
TFF3	7520.0
KAT5	7650.0
GNG3	7803.0
GNB3	8333.0
TFF1	8627.0
AREG	8661.0
EPGN	8968.0
PIK3R2	9202.0
ZNF217	9736.0
H2AC14	9915.0
AGO1	10289.0
GNGT2	10321.0

---

REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

	1272
set	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1
setSize	229
pANOVA	5.89e-05
s.dist	-0.154
p.adjustANOVA	0.00403

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GP1BA	-11099.0
CTSL	-11021.0
MIR27A	-10966.0
H2BC13	-10817.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
IL2	-10597.0
H3C8	-10552.0
CSF2	-10550.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
SOCS3	-9851.0
H4C12	-9845.0
KMT2C	-9762.0
CBX8	-9733.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GP1BA	-11099.0
CTSL	-11021.0
MIR27A	-10966.0
H2BC13	-10817.0
GATA3	-10779.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
IL2	-10597.0
H3C8	-10552.0
CSF2	-10550.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
SOCS3	-9851.0
H4C12	-9845.0
KMT2C	-9762.0
CBX8	-9733.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
NR4A3	-9622.0
CBX4	-9601.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
IL3	-9418.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
PSMA7	-9072.0
H3C11	-9013.0
PSMD9	-8887.0
PSMA6	-8781.0
PSMB10	-8751.0
RSPO3	-8699.0
H2BC15	-8620.0
PSMC2	-8506.0
RBBP5	-8494.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
TCF12	-7906.0
PSMF1	-7828.0
TAL1	-7764.0
CSNK2A2	-7701.0
PSMB3	-7613.0
SETD1A	-7232.0
PSMA4	-6953.0
PSMB8	-6727.0
PSMB1	-6458.0
PTPN11	-6297.0
CDK7	-6225.0
KCTD6	-6190.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
ASH2L	-5916.0
AUTS2	-5833.0
H2AZ2	-5775.0
RING1	-5768.0
H2BC11	-5756.0
KMT2D	-5563.0
ARID2	-5478.0
TNRC6B	-5455.0
PSMD4	-5443.0
SMARCD3	-5384.0
PSMB5	-5303.0
CSNK2B	-5291.0
LGALS3	-5279.0
UBB	-5278.0
GPAM	-5201.0
LDB1	-5103.0
PSMA3	-5040.0
H3C2	-4876.0
RUNX1	-4859.0
ELF2	-4857.0
KAT2B	-4853.0
TCF3	-4833.0
IFNG	-4723.0
PRKCQ	-4715.0
SCMH1	-4488.0
MYB	-4476.0
MNAT1	-4434.0
SIN3B	-4370.0
PHC3	-4300.0
MOV10	-4030.0
ACTL6A	-4005.0
PRMT1	-3642.0
CBX2	-3609.0
TNRC6A	-3455.0
WDR5	-3255.0
HDAC1	-3246.0
PSMB7	-3196.0
BLK	-3048.0
PSMA1	-3041.0
H4C4	-2969.0
PCGF5	-2747.0
YAF2	-2696.0
PSMC5	-2598.0
PSMD7	-2547.0
H4C11	-2506.0
PBRM1	-2503.0
DPY30	-2335.0
OCLN	-2331.0
LMO2	-2271.0
H2BC4	-2161.0
AGO2	-2087.0
UBC	-2067.0
H2AC6	-2051.0
SMARCE1	-1928.0
ITCH	-1877.0
CSNK2A1	-1846.0
PRKCB	-1707.0
IL2RA	-1554.0
EP300	-1428.0
H4C5	-1423.0
H3-3A	-1342.0
SIN3A	-1299.0
SPI1	-1209.0
CCNH	-1145.0
SOCS4	-1119.0
PSMB6	-1085.0
H2BC5	-999.0
THBS1	-977.0
PSMA5	-964.0
PSMB4	-949.0
CCND2	-858.0
PSMA2	-698.0
AXIN1	-582.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
SMARCD2	-427.0
YAP1	-378.0
SRC	-215.0
ESR1	-109.0
PSMD11	-47.0
HIPK2	199.0
PSME3	308.0
H4C3	423.0
PSMB9	675.0
CDK6	783.0
PML	823.0
PHC2	864.0
AGO3	957.0
SETD1B	971.0
PSMD5	1121.0
NFATC2	1132.0
H4C16	1337.0
BMI1	1398.0
CBFB	1427.0
SERPINB13	1436.0
PSMD12	1518.0
AGO4	1527.0
PHC1	1550.0
ABL1	1646.0
H2AJ	1704.0
PSMD13	1814.0
SMARCA2	1891.0
H2BC3	1965.0
PSMC4	1992.0
SMARCD1	2272.0
RUNX2	2370.0
H2BC21	2421.0
PSMD3	2572.0
PSMB2	2710.0
RNF2	2733.0
H2AZ1	2761.0
NFE2	2798.0
LIFR	2863.0
UBA52	2905.0
TJP1	2956.0
CCND1	2977.0
PSMC1	3545.0
ACTL6B	3600.0
PSME4	3824.0
PRMT6	4052.0
CREBBP	4132.0
ARID1B	4198.0
TNRC6C	4348.0
H4C2	4419.0
CCND3	4478.0
PSME2	4493.0
SMARCC2	4576.0
KMT2A	4645.0
PAX5	4856.0
PSMA8	4885.0
H3C3	4893.0
CBX6	5032.0
KMT2E	5064.0
H2AC20	5150.0
SMARCA4	5513.0
ELF1	5709.0
TP73	5955.0
H2BC14	6016.0
LMO1	6031.0
CTSV	6040.0
TNFRSF18	6070.0
H2BC1	6290.0
PSME1	6314.0
H3C1	6458.0
PF4	6765.0
H4C6	6913.0
GATA2	7123.0
SMARCB1	7448.0
CLDN5	7517.0
CR1	7578.0
ARID1A	7657.0
ITGA2B	7920.0
ZFPM1	8576.0
MYL9	9010.0
SMARCC1	9261.0
RYBP	9263.0
SEM1	9392.0
KMT2B	9642.0
H2AC14	9915.0
CTSK	9957.0
AGO1	10289.0
CTLA4	10350.0

---

REACTOME_DNA_REPAIR

REACTOME_DNA_REPAIR

	1168
set	REACTOME_DNA_REPAIR
setSize	321
pANOVA	6.38e-05
s.dist	-0.13
p.adjustANOVA	0.0041

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
PARG	-10802.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
RHNO1	-10392.0
POLE4	-10274.0
MPG	-10098.0
MSH6	-10092.0
FANCE	-10019.0
TOP3A	-9928.0
ASCC3	-9895.0
H4C9	-9887.0
UBA7	-9885.0
H4C12	-9845.0
UFD1	-9742.0
FAAP24	-9690.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
PARG	-10802.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
RHNO1	-10392.0
POLE4	-10274.0
MPG	-10098.0
MSH6	-10092.0
FANCE	-10019.0
TOP3A	-9928.0
ASCC3	-9895.0
H4C9	-9887.0
UBA7	-9885.0
H4C12	-9845.0
UFD1	-9742.0
FAAP24	-9690.0
H2AC8	-9679.0
AQR	-9667.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
ISG15	-9405.0
H2BC9	-9375.5
H2AC4	-9326.0
MBD4	-9288.0
ASCC2	-9225.0
PARP1	-9214.0
COPS8	-9115.0
BRCA1	-9099.0
ERCC8	-8981.0
RAD51D	-8859.0
DTL	-8843.0
RAD18	-8825.0
YY1	-8801.0
EYA4	-8733.0
MRE11	-8696.0
ACTR8	-8658.0
TFPT	-8653.0
H2BC15	-8620.0
INO80B	-8570.0
FANCG	-8516.0
COPS6	-8489.0
RFC5	-8423.0
H2AX	-8295.0
USP1	-8102.0
FANCC	-8101.0
LIG4	-8095.0
EYA3	-7980.0
H4C13	-7923.0
ERCC3	-7795.0
TDG	-7678.0
RBBP8	-7671.0
CHD1L	-7540.0
ATM	-7508.0
ATRIP	-7443.0
TIMELESS	-7424.0
UBE2V2	-7378.0
CUL4A	-7356.0
POLD2	-7345.0
TOPBP1	-7343.0
COPS5	-7337.0
BRCA2	-7328.0
PAXIP1	-7318.0
XPA	-7275.0
PMS2	-7243.0
TERF2IP	-7165.0
PIAS3	-6918.0
MSH3	-6744.0
DCLRE1A	-6672.0
COPS2	-6664.0
MAPK8	-6659.0
MLH1	-6596.0
FTO	-6571.0
BABAM2	-6564.0
RAD23B	-6499.0
TINF2	-6451.0
VCP	-6433.0
LIG1	-6397.0
RFC4	-6357.0
CDK7	-6225.0
RAD51	-6165.0
POLR2G	-6150.0
POLM	-6062.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
FANCL	-5945.0
RPS27A	-5922.0
TERF2	-5913.0
H2AZ2	-5775.0
H2BC11	-5756.0
INO80D	-5703.0
RFC1	-5699.0
RNF111	-5415.0
ISY1	-5387.0
CHEK1	-5363.0
UBB	-5278.0
SMARCA5	-5263.0
FAAP100	-5095.0
COPS7A	-4964.0
RCHY1	-4898.0
POLR2H	-4815.0
PPP4C	-4813.0
GTF2H5	-4812.0
ALKBH2	-4709.0
NFRKB	-4698.0
POLL	-4654.0
ERCC5	-4580.0
NBN	-4575.0
ATR	-4504.0
TDP1	-4483.0
POLK	-4469.0
MNAT1	-4434.0
UVSSA	-4198.0
MGMT	-4155.0
PPP4R2	-4154.0
DCLRE1B	-4128.0
POLR2L	-4064.0
CCNA1	-4010.0
ACTL6A	-4005.0
BARD1	-3957.0
TP53	-3947.0
COPS4	-3725.0
POLE3	-3713.0
FANCF	-3696.0
BLM	-3594.0
XRCC2	-3533.0
RMI2	-3522.0
MCRS1	-3515.0
BRIP1	-3490.0
PARP2	-3484.0
SPIDR	-3463.0
WRN	-3454.0
USP10	-3341.0
PRKDC	-3303.0
ACTB	-3090.0
KDM4A	-3074.0
HMGN1	-3001.0
POLR2I	-2974.0
H4C4	-2969.0
RAD17	-2958.0
PALB2	-2951.0
APEX1	-2732.0
TP53BP1	-2701.0
XRCC1	-2668.0
RIF1	-2562.0
H4C11	-2506.0
MDC1	-2451.0
SIRT6	-2376.0
POLE	-2169.0
H2BC4	-2161.0
UBC	-2067.0
H2AC6	-2051.0
UBE2N	-2050.0
DDB2	-2043.0
CLSPN	-1972.0
RFC3	-1900.0
RMI1	-1872.0
XRCC6	-1860.0
BAZ1B	-1820.0
POLH	-1776.0
ERCC6	-1695.0
USP43	-1650.0
EME2	-1571.0
EP300	-1428.0
H4C5	-1423.0
SLX4	-1260.0
HUS1	-1217.0
GEN1	-1199.0
DCLRE1C	-1175.0
DNA2	-1169.0
POLR2F	-1161.0
CCNH	-1145.0
INO80C	-1139.0
H2BC5	-999.0
RNF8	-986.0
UIMC1	-983.0
POLI	-918.0
RAD51B	-910.0
ALKBH3	-890.0
RAD51AP1	-887.0
KDM4B	-876.0
USP45	-868.0
EME1	-823.0
FAAP20	-817.0
FANCM	-803.0
POLR2A	-696.0
PRPF19	-636.0
LIG3	-612.0
H2BC12	-482.0
XRCC4	-358.0
RPA3	-298.0
NSD2	-283.0
RBX1	-261.0
ERCC1	-249.0
POT1	-227.0
PCLAF	-213.0
GTF2H1	-188.0
DDB1	-146.0
POLB	-129.0
INO80E	-94.0
PCNA	79.0
ERCC4	192.0
NPLOC4	265.0
CCNA2	268.0
ZNF830	409.0
H4C3	423.0
UBE2I	584.0
NEIL3	631.0
XAB2	633.0
PPP5C	716.0
EYA2	756.0
SUMO1	802.0
NEIL1	900.0
PIAS1	926.0
RAD50	1099.0
FANCA	1109.0
POLD1	1119.0
NEIL2	1221.0
H4C16	1337.0
HERC2	1352.0
XPC	1358.0
INO80	1408.0
REV3L	1601.0
FANCI	1630.0
ABL1	1646.0
H2AJ	1704.0
CDK2	1892.0
TERF1	1919.0
H2BC3	1965.0
ACD	2104.5
SMUG1	2274.0
PPIE	2282.0
RFC2	2285.0
H3-4	2321.0
UBE2L6	2372.0
H2BC21	2421.0
PIAS4	2600.0
RAD1	2602.0
MSH2	2623.0
ALKBH5	2692.0
ELL	2755.0
H2AZ1	2761.0
POLR2B	2810.0
POLQ	2891.0
BAP1	2903.0
UBA52	2905.0
WDR48	3105.0
KPNA2	3395.0
RAD9A	3485.0
EXO1	3564.0
FANCD2	3740.0
POLD3	3753.0
ACTR5	3806.0
FAN1	4110.0
POLR2J	4123.0
UBXN1	4169.0
NHEJ1	4222.0
COPS3	4246.0
SUMO2	4383.0
H4C2	4419.0
TIPIN	4439.0
SUMO3	4467.0
MUTYH	4565.0
POLR2C	4579.0
GTF2H4	4615.0
APBB1	4666.0
RAD9B	4895.0
UBE2B	4953.0
BABAM1	4984.0
CHEK2	5010.0
XRCC5	5142.0
H2AC20	5150.0
GTF2H3	5292.0
TDP2	5313.0
PNKP	5338.0
POLD4	5396.0
EYA1	5503.0
TRIM25	5607.0
UNG	5756.0
MUS81	5791.0
H2BC14	6016.0
MAD2L2	6079.0
RPA1	6175.0
H2BC1	6290.0
SPRTN	6369.0
RNF168	6513.0
POLR2E	6530.0
ASCC1	6779.0
H4C6	6913.0
POLR2D	6966.0
REV1	7178.0
POLN	7200.0
ABRAXAS1	7405.0
RAD23A	7523.0
RNF4	7590.0
ERCC2	7598.0
KAT5	7650.0
FEN1	7913.0
RAD51C	7987.0
RTEL1	8029.0
COPS7B	8086.0
USP7	8359.0
TCEA1	8431.0
NTHL1	8655.0
CENPS	8690.0
OGG1	9143.0
RAD52	9375.0
SEM1	9392.0
GPS1	9515.0
ADPRS	9653.0
RPA2	9677.0
UBE2T	9717.0
H2AC14	9915.0
XRCC3	10022.0
POLE2	10051.0

---

REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

	853
set	REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION
setSize	100
pANOVA	6.63e-05
s.dist	-0.231
p.adjustANOVA	0.0041

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0
H3C11	-9013.0
SAP30	-9007.0
MBD2	-8673.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
SAP30BP	-7965.0
H4C13	-7923.0
H3C6	-7918.0
POLR1E	-7855.0
ERCC3	-7795.0
POLR1B	-7397.0
CDK7	-6225.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
DNMT1	-5876.0
H2AZ2	-5775.0
H2BC11	-5756.0
SUDS3	-5467.0
SMARCA5	-5263.0
H3C2	-4876.0
POLR2H	-4815.0
GTF2H5	-4812.0
POLR1G	-4538.0
MNAT1	-4434.0
SIN3B	-4370.0
POLR1D	-4307.0
ARID4B	-4090.0
POLR2L	-4064.0
POLR1C	-3745.0
HDAC1	-3246.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
RRP8	-2160.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
SIN3A	-1299.0
POLR1H	-1267.0
POLR2F	-1161.0
CCNH	-1145.0
H2BC5	-999.0
H2BC12	-482.0
GTF2H1	-188.0
H4C3	423.0
TAF1A	554.0
TBP	561.0
SIRT1	613.0
H4C16	1337.0
H2AJ	1704.0
SAP18	1866.0
H2BC3	1965.0
TAF1C	2010.0
H2BC21	2421.0
POLR1F	2760.0
H2AZ1	2761.0
TTF1	3503.0
TAF1B	3685.0
DNMT3B	3986.0
SAP130	4097.0
H4C2	4419.0
GTF2H4	4615.0
POLR1A	4622.0
H3C3	4893.0
H2AC20	5150.0
BAZ2A	5271.0
GTF2H3	5292.0
SAP30L	5623.0
H2BC14	6016.0
HDAC2	6155.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
ERCC2	7598.0
UBTF	7947.0
H2AC14	9915.0

---

REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH

REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH

	1502
set	REACTOME_DISEASES_OF_PROGRAMMED_CELL_DEATH
setSize	96
pANOVA	6.74e-05
s.dist	-0.235
p.adjustANOVA	0.0041

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
GOLGA2	-10275.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
MLKL	-9178.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
GOLGA2	-10275.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
MLKL	-9178.0
H3C11	-9013.0
PRDX1	-8962.0
FADD	-8690.0
H2BC15	-8620.0
CDC25B	-8586.0
CAST	-8311.0
H2AX	-8295.0
H3-3B	-8282.0
CDKN2A	-8076.0
H4C13	-7923.0
H3C6	-7918.0
PRDX2	-7551.0
PRIM2	-7259.0
EZH2	-6787.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
PRIM1	-5927.0
DNMT1	-5876.0
H2AZ2	-5775.0
H2BC11	-5756.0
SOD2	-5530.0
FASLG	-5399.0
POLA2	-5226.0
CASP8	-5197.0
H3C2	-4876.0
CAPNS1	-4078.0
TP53	-3947.0
DNMT3A	-3540.0
RBBP4	-3061.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
H2AC6	-2051.0
LMNA	-1442.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
EED	-862.0
CDC25A	-853.0
JUN	-686.0
H2BC12	-482.0
FOXO3	-113.0
SUZ12	106.0
H4C3	423.0
CDC25C	1212.0
H4C16	1337.0
H2AJ	1704.0
YWHAE	1817.0
CAPN1	1832.0
LMNB1	1840.0
H2BC3	1965.0
H2BC21	2421.0
RIPK1	2479.0
H2AZ1	2761.0
CAPN2	3057.0
BCL2L11	3314.0
DNMT3B	3986.0
CDK5	4008.0
H4C2	4419.0
C1QBP	4571.0
H3C3	4893.0
GSDME	5048.0
H2AC20	5150.0
RIPK3	5201.0
TRADD	5589.0
APP	5881.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
TRAF2	8733.0
H2AC14	9915.0
CDK5R1	9974.0
CAPNS2	10132.0

---

REACTOME_MEIOSIS

REACTOME_MEIOSIS

	138
set	REACTOME_MEIOSIS
setSize	110
pANOVA	7.55e-05
s.dist	-0.218
p.adjustANOVA	0.00442

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TEX15	-10877.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
TOP3A	-9928.0
H4C9	-9887.0
REC8	-9877.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TEX15	-10877.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
TOP3A	-9928.0
H4C9	-9887.0
REC8	-9877.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
BRCA1	-9099.0
H3C11	-9013.0
MSH4	-8868.0
MRE11	-8696.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
RBBP8	-7671.0
CDK4	-7529.0
ATM	-7508.0
BRCA2	-7328.0
TERF2IP	-7165.0
MLH1	-6596.0
SYCE3	-6558.0
TINF2	-6451.0
RAD51	-6165.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
TERF2	-5913.0
H2AZ2	-5775.0
H2BC11	-5756.0
MLH3	-5618.0
H3C2	-4876.0
SPO11	-4713.0
SMC3	-4651.0
NBN	-4575.0
ATR	-4504.0
BLM	-3594.0
H4C4	-2969.0
H4C11	-2506.0
SYCP2	-2199.0
H2BC4	-2161.0
H2AC6	-2051.0
MND1	-1870.0
SYNE1	-1758.0
LMNA	-1442.0
STAG1	-1424.0
H4C5	-1423.0
H3-3A	-1342.0
SYNE2	-1194.0
H2BC5	-999.0
SUN1	-595.0
H2BC12	-482.0
RPA3	-298.0
POT1	-227.0
HSPA2	-223.0
FKBP6	47.0
H4C3	423.0
UBE2I	584.0
TEX12	994.0
PSMC3IP	1060.0
RAD50	1099.0
STAG3	1111.0
H4C16	1337.0
H2AJ	1704.0
SMC1B	1798.0
LMNB1	1840.0
CDK2	1892.0
TERF1	1919.0
H2BC3	1965.0
ACD	2104.5
H3-4	2321.0
MSH5	2404.0
H2BC21	2421.0
H2AZ1	2761.0
DIDO1	2794.0
SYCP3	3255.0
RAD21	3920.0
H4C2	4419.0
SUN2	4523.0
SYCE1	4551.0
SYCP1	4612.0
H3C3	4893.0
H2AC20	5150.0
SYCE2	5965.0
H2BC14	6016.0
RPA1	6175.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
DMC1	6937.0
RAD51C	7987.0
PRDM9	8445.0
RPA2	9677.0
H2AC14	9915.0

---

REACTOME_HCMV_LATE_EVENTS

REACTOME_HCMV_LATE_EVENTS

	1466
set	REACTOME_HCMV_LATE_EVENTS
setSize	110
pANOVA	7.99e-05
s.dist	-0.218
p.adjustANOVA	0.00452

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
CHMP4C	-10367.0
NUP85	-10122.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
CHMP4C	-10367.0
NUP85	-10122.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
CHMP4B	-8724.0
H2BC15	-8620.0
H2AC13	-8341.0
H4C13	-7923.0
H3C6	-7918.0
NDC1	-7758.0
NUP153	-7417.0
CEBPD	-7233.0
NUP50	-7103.0
CHMP1A	-6807.0
VPS37D	-6738.0
NUP35	-6340.0
H2AC17	-6215.0
HNRNPK	-6138.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
CHMP4A	-5881.0
NUP107	-5851.0
H2AC25	-5804.0
H2BC11	-5756.0
H2AC15	-5344.0
H3C2	-4876.0
NUP160	-4777.0
NUP93	-4202.0
RANBP2	-4186.0
NUP37	-4123.0
SEC13	-4109.0
POM121	-4065.0
NUP98	-3940.0
NUP88	-3822.0
VPS37B	-3682.0
H2AC11	-3666.0
VPS37C	-3663.0
NUP54	-3291.0
H4C4	-2969.0
TPR	-2693.0
NUP205	-2604.0
H4C11	-2506.0
CHMP2A	-2484.0
CHMP7	-2480.0
H2BC4	-2161.0
NUP214	-2055.0
H2AC6	-2051.0
TSG101	-1904.0
POM121C	-1851.0
VPS4A	-1614.0
H2AC16	-1553.0
H4C5	-1423.0
H2BC5	-999.0
H2AC21	-716.0
H2BC12	-482.0
VPS25	-336.0
H4C3	423.0
VPS37A	642.0
MVB12B	928.0
H4C16	1337.0
AAAS	1385.0
NUP133	1721.0
NUP155	1883.0
H2BC3	1965.0
MVB12A	1966.0
CHMP3	1967.0
NUP58	2106.0
H2BC21	2421.0
SEH1L	2648.0
VPS28	3267.0
VPS36	3426.0
RAE1	3695.0
UBAP1	4024.0
NUP188	4396.0
NUP42	4406.0
H4C2	4419.0
H2AC1	4742.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
NUP43	6107.0
H2BC1	6290.0
H3C1	6458.0
CHMP6	6620.0
H4C6	6913.0
CHMP2B	6950.0
SNF8	7597.0
NUP210	7811.0
NUP62	7909.0
H2AC12	8376.0
H2AC14	9915.0

---

REACTOME_MITOTIC_PROPHASE

REACTOME_MITOTIC_PROPHASE

	1093
set	REACTOME_MITOTIC_PROPHASE
setSize	134
pANOVA	8.45e-05
s.dist	-0.197
p.adjustANOVA	0.00462

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
RB1	-10297.0
GOLGA2	-10275.0
NUP85	-10122.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
NEK9	-9647.0
SMC4	-9624.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
RB1	-10297.0
GOLGA2	-10275.0
NUP85	-10122.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
NEK9	-9647.0
SMC4	-9624.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
CNEP1R1	-9147.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
NDC1	-7758.0
VRK2	-7676.0
MAPK3	-7607.0
NUP153	-7417.0
TMPO	-7209.0
NUP50	-7103.0
NUP35	-6340.0
PPP2R1B	-6311.0
VRK1	-6053.0
RAB2A	-6038.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
NUP107	-5851.0
SMC2	-5782.0
H2AZ2	-5775.0
H2BC11	-5756.0
MCPH1	-5392.0
GORASP1	-5340.0
USO1	-5204.0
CCNB1	-5146.0
H3C2	-4876.0
NUP160	-4777.0
BANF1	-4346.0
PPP2R1A	-4275.0
NUP93	-4202.0
RANBP2	-4186.0
NUP37	-4123.0
SEC13	-4109.0
POM121	-4065.0
NUP98	-3940.0
MASTL	-3904.0
NUP88	-3822.0
LEMD3	-3710.0
NUP54	-3291.0
NCAPG2	-3067.0
RAB1B	-3018.0
H4C4	-2969.0
TPR	-2693.0
NUP205	-2604.0
NEK7	-2533.0
H4C11	-2506.0
H2BC4	-2161.0
NUP214	-2055.0
H2AC6	-2051.0
POM121C	-1851.0
PRKCB	-1707.0
LMNA	-1442.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
NCAPD3	-911.0
CCNB2	-898.0
ENSA	-882.0
CTDNEP1	-683.0
H2BC12	-482.0
BLZF1	123.0
H4C3	423.0
LPIN1	489.0
PRKCA	547.0
CDK1	604.0
LEMD2	667.0
KMT5A	861.0
H4C16	1337.0
NCAPH2	1353.0
AAAS	1385.0
MAPK1	1551.0
H2AJ	1704.0
NUP133	1721.0
LMNB1	1840.0
NUP155	1883.0
H2BC3	1965.0
NUP58	2106.0
H3-4	2321.0
H2BC21	2421.0
SEH1L	2648.0
H2AZ1	2761.0
PLK1	3423.0
RAE1	3695.0
PPP2R2D	4394.0
NUP188	4396.0
NUP42	4406.0
H4C2	4419.0
NUMA1	4544.0
PPP2CB	4668.0
H3C3	4893.0
H2AC20	5150.0
RAB1A	5210.0
H2BC14	6016.0
NUP43	6107.0
ARPP19	6160.0
H2BC1	6290.0
LPIN2	6336.0
H3C1	6458.0
LPIN3	6693.0
PPP2CA	6732.0
H4C6	6913.0
NUP210	7811.0
NUP62	7909.0
NEK6	8099.0
SET	8189.0
GORASP2	8919.0
H2AC14	9915.0

---

REACTOME_G2_M_CHECKPOINTS

REACTOME_G2_M_CHECKPOINTS

	1116
set	REACTOME_G2_M_CHECKPOINTS
setSize	162
pANOVA	9.11e-05
s.dist	-0.178
p.adjustANOVA	0.00483

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2BC7	-10629.5
RHNO1	-10392.0
YWHAB	-10128.0
TOP3A	-9928.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
PSMC6	-9675.0
H2BC8	-9584.0
H2BC17	-9503.0
PSMD14	-9466.0
H2BC9	-9375.5
YWHAQ	-9275.0
PSMC3	-9217.0
BRCA1	-9099.0
PSMA7	-9072.0
PSMD9	-8887.0
MCM4	-8837.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2BC7	-10629.5
RHNO1	-10392.0
YWHAB	-10128.0
TOP3A	-9928.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
PSMC6	-9675.0
H2BC8	-9584.0
H2BC17	-9503.0
PSMD14	-9466.0
H2BC9	-9375.5
YWHAQ	-9275.0
PSMC3	-9217.0
BRCA1	-9099.0
PSMA7	-9072.0
PSMD9	-8887.0
MCM4	-8837.0
PSMA6	-8781.0
PSMB10	-8751.0
MRE11	-8696.0
H2BC15	-8620.0
PSMC2	-8506.0
RFC5	-8423.0
PSMB11	-8322.0
H2AX	-8295.0
H4C13	-7923.0
CDC7	-7868.0
PSMF1	-7828.0
RBBP8	-7671.0
PSMB3	-7613.0
WEE1	-7583.0
ATM	-7508.0
ATRIP	-7443.0
UBE2V2	-7378.0
TOPBP1	-7343.0
PSMA4	-6953.0
ORC1	-6900.0
MCM8	-6772.0
PSMB8	-6727.0
ORC5	-6642.0
BABAM2	-6564.0
PSMB1	-6458.0
RFC4	-6357.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
YWHAH	-5939.0
RPS27A	-5922.0
H2BC11	-5756.0
DBF4	-5544.0
PSMD4	-5443.0
CHEK1	-5363.0
PSMB5	-5303.0
UBB	-5278.0
CCNB1	-5146.0
PSMA3	-5040.0
NBN	-4575.0
ATR	-4504.0
CDC45	-4296.0
BARD1	-3957.0
TP53	-3947.0
BLM	-3594.0
RMI2	-3522.0
BRIP1	-3490.0
WRN	-3454.0
PSMB7	-3196.0
MCM3	-3095.0
PSMA1	-3041.0
H4C4	-2969.0
RAD17	-2958.0
TP53BP1	-2701.0
ORC4	-2672.0
ORC6	-2669.0
PSMC5	-2598.0
PSMD7	-2547.0
H4C11	-2506.0
MDC1	-2451.0
H2BC4	-2161.0
YWHAZ	-2100.0
UBC	-2067.0
UBE2N	-2050.0
CLSPN	-1972.0
RFC3	-1900.0
RMI1	-1872.0
MCM6	-1605.0
H4C5	-1423.0
MCM10	-1302.0
HUS1	-1217.0
DNA2	-1169.0
PSMB6	-1085.0
H2BC5	-999.0
RNF8	-986.0
UIMC1	-983.0
PSMA5	-964.0
PSMB4	-949.0
CCNB2	-898.0
CDC25A	-853.0
YWHAG	-766.0
PSMA2	-698.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
CDC6	-419.0
RPA3	-298.0
NSD2	-283.0
ORC2	-95.0
PSMD11	-47.0
PSME3	308.0
H4C3	423.0
CDK1	604.0
PSMB9	675.0
RAD50	1099.0
PSMD5	1121.0
CDC25C	1212.0
H4C16	1337.0
HERC2	1352.0
PSMD12	1518.0
MCM2	1539.0
PSMD13	1814.0
YWHAE	1817.0
CDK2	1892.0
H2BC3	1965.0
PSMC4	1992.0
RFC2	2285.0
H3-4	2321.0
H2BC21	2421.0
PSMD3	2572.0
PIAS4	2600.0
RAD1	2602.0
PSMB2	2710.0
UBA52	2905.0
ORC3	3240.0
RAD9A	3485.0
PSMC1	3545.0
EXO1	3564.0
PSME4	3824.0
H4C2	4419.0
PSME2	4493.0
PSMA8	4885.0
RAD9B	4895.0
BABAM1	4984.0
GTSE1	4995.0
CHEK2	5010.0
H2BC14	6016.0
RPA1	6175.0
H2BC1	6290.0
PSME1	6314.0
RNF168	6513.0
H4C6	6913.0
ABRAXAS1	7405.0
KAT5	7650.0
MCM7	7817.0
PKMYT1	7970.0
SEM1	9392.0
RPA2	9677.0
SFN	9832.0
MCM5	10021.0

---

REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

	379
set	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT
setSize	222
pANOVA	9.65e-05
s.dist	-0.152
p.adjustANOVA	0.00489

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
RSPO2	-10134.0
H3C4	-10062.0
PYGO1	-9986.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
RSPO2	-10134.0
H3C4	-10062.0
PYGO1	-9986.0
H4C9	-9887.0
H4C12	-9845.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PSMD14	-9466.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
PSMC3	-9217.0
XPO1	-9161.0
PSMA7	-9072.0
H3C11	-9013.0
CSNK1A1	-8958.0
PSMD9	-8887.0
PSMA6	-8781.0
PSMB10	-8751.0
RSPO3	-8699.0
H2BC15	-8620.0
WNT8B	-8597.0
PSMC2	-8506.0
RBBP5	-8494.0
AXIN2	-8451.0
PSMB11	-8322.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
DKK1	-7858.0
KLHL12	-7831.0
PSMF1	-7828.0
CSNK1E	-7784.0
CSNK2A2	-7701.0
PSMB3	-7613.0
SOX9	-7596.0
PSMA4	-6953.0
PSMB8	-6727.0
FZD2	-6598.0
PSMB1	-6458.0
FZD8	-6317.0
PPP2R1B	-6311.0
DVL1	-6273.0
PPP2R5B	-6192.0
H4C8	-5994.0
CDC73	-5992.0
PPP2R5D	-5981.0
H2BC26	-5963.0
TLE1	-5957.0
RYK	-5956.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
ASH2L	-5916.0
SOX4	-5862.0
H2AZ2	-5775.0
H2BC11	-5756.0
SOX17	-5673.0
BTRC	-5601.0
DVL2	-5575.0
KMT2D	-5563.0
PSMD4	-5443.0
CXXC4	-5348.0
PSMB5	-5303.0
CSNK2B	-5291.0
TLE4	-5289.0
UBB	-5278.0
BCL9	-5176.0
WNT5A	-5085.0
PSMA3	-5040.0
FZD1	-4931.0
H3C2	-4876.0
SOX7	-4630.0
APC	-4513.0
PPP2R1A	-4275.0
WIF1	-4181.0
DVL3	-4170.0
ZNRF3	-4125.0
GSK3B	-4058.0
TCF7	-3950.0
TNKS	-3719.0
LGR4	-3543.0
WNT3A	-3457.0
HDAC1	-3246.0
PSMB7	-3196.0
PYGO2	-3184.0
CTNNBIP1	-3144.0
PSMA1	-3041.0
H4C4	-2969.0
SOX2	-2653.0
FZD6	-2651.0
PSMC5	-2598.0
SFRP2	-2591.0
PSMD7	-2547.0
H4C11	-2506.0
LEO1	-2458.0
RNF146	-2315.0
TNKS2	-2222.0
H2BC4	-2161.0
YWHAZ	-2100.0
UBC	-2067.0
H2AC6	-2051.0
CSNK2A1	-1846.0
PPP2R5C	-1840.0
FRAT1	-1809.0
EP300	-1428.0
H4C5	-1423.0
MEN1	-1348.0
H3-3A	-1342.0
PSMB6	-1085.0
H2BC5	-999.0
PSMA5	-964.0
PSMB4	-949.0
TLE3	-833.0
PSMA2	-698.0
PPP2R5E	-634.0
AXIN1	-582.0
CBY1	-559.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
FZD4	-310.0
RBX1	-261.0
LEF1	-58.0
PSMD11	-47.0
DACT1	76.0
SOX6	116.0
PSME3	308.0
H4C3	423.0
PIP5K1B	590.0
CTNNB1	601.0
PSMB9	675.0
SOX13	734.0
PPP2R5A	866.0
USP34	912.0
CHD8	930.0
PSMD5	1121.0
CCDC88C	1170.0
H4C16	1337.0
LRP6	1367.0
MYC	1474.0
DKK2	1493.0
PSMD12	1518.0
H2AJ	1704.0
PSMD13	1814.0
H2BC3	1965.0
TLE2	1987.0
LGR6	1988.0
PSMC4	1992.0
CUL3	2108.0
H3-4	2321.0
LGR5	2384.0
H2BC21	2421.0
PSMD3	2572.0
TRRAP	2621.0
PSMB2	2710.0
H2AZ1	2761.0
UBA52	2905.0
SOST	3232.0
HECW1	3295.0
TCF4	3383.0
USP8	3412.0
WNT4	3459.0
PSMC1	3545.0
SMURF2	3581.0
CAV1	3754.0
PSME4	3824.0
AKT2	3850.0
RNF43	3938.0
KREMEN1	4051.0
CREBBP	4132.0
TCF7L2	4369.0
H4C2	4419.0
PSME2	4493.0
PPP2CB	4668.0
TCF7L1	4753.0
CTBP1	4845.0
PSMA8	4885.0
H3C3	4893.0
FRAT2	5101.0
H2AC20	5150.0
RSPO4	5233.0
WNT3	5387.0
LRP5	5499.0
SMARCA4	5513.0
AKT1	5667.0
TERT	5815.0
H2BC14	6016.0
H2BC1	6290.0
PSME1	6314.0
H3C1	6458.0
RSPO1	6524.0
PPP2CA	6732.0
H4C6	6913.0
WNT9A	7149.0
WNT8A	7467.0
KAT5	7650.0
CSNK1G2	7793.0
KREMEN2	7860.0
SFRP1	7875.0
WNT1	8335.0
RUNX3	9284.0
SEM1	9392.0
FZD5	9681.0
H2AC14	9915.0
DKK4	10128.0
BCL9L	10351.0

---

REACTOME_KERATINIZATION

REACTOME_KERATINIZATION

	1073
set	REACTOME_KERATINIZATION
setSize	210
pANOVA	9.84e-05
s.dist	0.156
p.adjustANOVA	0.00489

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRTAP3-3	10552
KRT72	10550
SPRR2E	10471
KRT14	10405
LIPN	10355
LCE2B	10325
KRT38	10315
KRT13	10264
KRTAP10-10	10192
KRT4	10023
KRTAP1-4	9997
KRT83	9983
KRTAP2-2	9975
KRT6B	9911
KRT78	9820
KRTAP12-4	9795
KRT79	9727
KRTAP29-1	9720
KRT86	9682
KRT80	9678

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRTAP3-3	10552
KRT72	10550
SPRR2E	10471
KRT14	10405
LIPN	10355
LCE2B	10325
KRT38	10315
KRT13	10264
KRTAP10-10	10192
KRT4	10023
KRTAP1-4	9997
KRT83	9983
KRTAP2-2	9975
KRT6B	9911
KRT78	9820
KRTAP12-4	9795
KRT79	9727
KRTAP29-1	9720
KRT86	9682
KRT80	9678
KRTAP17-1	9547
KRT2	9537
KRTAP9-1	9502
KRTAP19-2	9380
KRT24	9367
KRTAP10-4	9346
CELA2A	9331
KRTAP5-11	9275
SPRR1B	9264
KRTAP4-6	9229
KRT74	9057
SPINK6	9038
LCE6A	9034
KRTAP10-6	8996
KLK14	8967
KRT3	8913
LIPK	8854
PKP1	8839
KRTAP5-7	8751
SPRR3	8713
KRTAP4-11	8603
KRT6A	8602
KRTAP4-3	8252
KRT73	8248
KRT18	8217
TCHH	8090
KRT25	8068
KRTAP4-8	7946
PRSS8	7877
KRT40	7759
CDSN	7750
LCE2C	7702
KRT82	7466
KRTAP3-1	7444
PKP3	7441
KRTAP4-4	7430
KRTAP10-3	7411
TGM1	7395
KRTAP4-5	7338
KRTAP5-10	7261
KLK13	7244
KRTAP6-1	6977
KRTAP3-2	6962
KRTAP13-1	6793
KRTAP10-7	6704
KRT36	6627
KRT33A	6618
CSTA	6608
KRTAP9-6	6564
KRT7	6541
KRTAP5-4	6435
KRT81	6424
KRTAP19-4	6260
LCE1C	6186
KRT23	6084
EVPL	6052
KRTAP16-1	5870
LCE5A	5827
LCE1F	5696
DSC1	5683
LCE3A	5518
LELP1	5435
SPINK5	5320
KLK5	5268
KRT19	5145
LCE2D	5082
KRTAP15-1	5037
DSG2	5002
KAZN	4986
KRT75	4909
PCSK6	4864
KRTAP13-2	4574
LCE1E	4489
RPTN	4449
KRT15	4357
KRT17	4302
KRTAP5-5	4256
KRTAP8-1	4217
KRTAP10-12	4125
PPL	4122
KRT28	4046
KRT77	3979
KRT8	3767
LCE1B	3730
KRT71	3417
KRTAP19-7	3387
KRTAP21-3	3359
LCE1A	2636
KRT32	2557
DSG3	2373
PKP2	2310
KRTAP12-3	2232
KRT34	2018
LCE3E	1948
CAPN1	1832
KRTAP21-2	1553
KRTAP4-1	1245
KRTAP11-1	1226
KRTAP23-1	1194
PI3	1030
KLK8	993
KRTAP1-5	938
JUP	492
SPINK9	420
KRT20	322
ST14	203
DSG4	108
KRTAP9-4	34
KRT26	13
KRT27	-159
KRTAP13-3	-287
KRTAP20-1	-369
KRTAP4-7	-736
IVL	-812
PKP4	-852
KRTAP1-3	-1061
SPRR2A	-1275
KRTAP2-1	-1325
KRT6C	-1515
KLK12	-2062
KRTAP19-3	-2716
KRTAP27-1	-2828
SPRR2D	-2997
KRTAP2-4	-3072
KRTAP10-2	-3234
SPRR1A	-3276
KRTAP21-1	-3310
DSP	-3441
LIPM	-3466
KRTAP12-2	-3489
FURIN	-3491
KRTAP5-2	-3592
LIPJ	-3968
CAPNS1	-4078
KRTAP19-8	-4103
KRTAP19-6	-4213
PERP	-4437
KRTAP9-9	-4565
KRTAP9-2	-5023
KRT12	-5161
KRTAP24-1	-5308
KRT85	-5434
KRT10	-5539
KRTAP6-3	-5653
KRT5	-5660
SPRR2F	-5830
KRT33B	-6359
KRT1	-6379
KRT9	-6600
KRTAP22-1	-6652
KRTAP26-1	-6872
FLG	-6893
KRTAP12-1	-7203
KRTAP25-1	-7419
KRTAP20-2	-7423
KRT39	-7535
LCE3B	-8050
LCE2A	-8472
KRT84	-8618
KRT37	-8836
SPRR2G	-9031
KRTAP5-9	-9038
KRT31	-9188
KRTAP13-4	-9289
LCE4A	-9396
CASP14	-9605
DSC3	-9829
KRTAP9-3	-9868
KRTAP6-2	-9917
KRTAP10-1	-10038
KRTAP4-2	-10188
KRT76	-10430
KRTAP5-3	-10479
KRTAP19-5	-10510
KRTAP10-8	-10708
KRTAP1-1	-10795
TGM5	-10823
KRT35	-10886
DSC2	-10901
KRTAP10-11	-10916
DSG1	-10935
KRTAP5-6	-10976
KRTAP2-3	-11015
KRTAP19-1	-11035
KRTAP10-5	-11041
LCE3D	-11055
KRTAP5-8	-11182
KRTAP10-9	-11290
KRTAP5-1	-11321
KRT16	-11331

---

REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

	1279
set	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION
setSize	90
pANOVA	0.000118
s.dist	-0.235
p.adjustANOVA	0.0057

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GP1BA	-11099.0
MIR27A	-10966.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
KMT2C	-9762.0
H2AC8	-9679.0
NR4A3	-9622.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GP1BA	-11099.0
MIR27A	-10966.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
KMT2C	-9762.0
H2AC8	-9679.0
NR4A3	-9622.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
RBBP5	-8494.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
SETD1A	-7232.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
ASH2L	-5916.0
H2AZ2	-5775.0
H2BC11	-5756.0
KMT2D	-5563.0
TNRC6B	-5455.0
H3C2	-4876.0
RUNX1	-4859.0
KAT2B	-4853.0
PRKCQ	-4715.0
SIN3B	-4370.0
MOV10	-4030.0
PRMT1	-3642.0
TNRC6A	-3455.0
WDR5	-3255.0
HDAC1	-3246.0
H4C4	-2969.0
H4C11	-2506.0
DPY30	-2335.0
H2BC4	-2161.0
H2AC6	-2051.0
EP300	-1428.0
H4C5	-1423.0
H3-3A	-1342.0
SIN3A	-1299.0
H2BC5	-999.0
THBS1	-977.0
H2BC12	-482.0
H4C3	423.0
AGO3	957.0
SETD1B	971.0
H4C16	1337.0
CBFB	1427.0
AGO4	1527.0
H2AJ	1704.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
NFE2	2798.0
PRMT6	4052.0
TNRC6C	4348.0
H4C2	4419.0
KMT2A	4645.0
H3C3	4893.0
KMT2E	5064.0
H2AC20	5150.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
PF4	6765.0
H4C6	6913.0
ITGA2B	7920.0
ZFPM1	8576.0
MYL9	9010.0
KMT2B	9642.0
H2AC14	9915.0
AGO1	10289.0

---

REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

	887
set	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS
setSize	100
pANOVA	0.00016
s.dist	-0.218
p.adjustANOVA	0.00726

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
NUP85	-10122.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
NUP85	-10122.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
NDC1	-7758.0
NUP153	-7417.0
IPO8	-7264.0
NUP50	-7103.0
NUP35	-6340.0
POLR2G	-6150.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
NUP107	-5851.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
POLR2H	-4815.0
NUP160	-4777.0
NUP93	-4202.0
RANBP2	-4186.0
NUP37	-4123.0
SEC13	-4109.0
POM121	-4065.0
POLR2L	-4064.0
NUP98	-3940.0
NUP88	-3822.0
TNRC6A	-3455.0
NUP54	-3291.0
POLR2I	-2974.0
H4C4	-2969.0
TPR	-2693.0
NUP205	-2604.0
H4C11	-2506.0
H2BC4	-2161.0
AGO2	-2087.0
NUP214	-2055.0
H2AC6	-2051.0
POM121C	-1851.0
H4C5	-1423.0
H3-3A	-1342.0
POLR2F	-1161.0
H2BC5	-999.0
POLR2A	-696.0
H2BC12	-482.0
H4C3	423.0
H4C16	1337.0
AAAS	1385.0
H2AJ	1704.0
NUP133	1721.0
NUP155	1883.0
H2BC3	1965.0
NUP58	2106.0
H2BC21	2421.0
SEH1L	2648.0
H2AZ1	2761.0
POLR2B	2810.0
RAE1	3695.0
POLR2J	4123.0
RAN	4175.0
NUP188	4396.0
NUP42	4406.0
H4C2	4419.0
POLR2C	4579.0
H3C3	4893.0
H2AC20	5150.0
H2BC14	6016.0
NUP43	6107.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
POLR2D	6966.0
NUP210	7811.0
NUP62	7909.0
H2AC14	9915.0
AGO1	10289.0

---

REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

	901
set	REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS
setSize	113
pANOVA	0.000163
s.dist	-0.205
p.adjustANOVA	0.00726

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
KMT2C	-9762.0
PAX6	-9707.0
H2AC8	-9679.0
HOXB4	-9612.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
KMT2C	-9762.0
PAX6	-9707.0
H2AC8	-9679.0
HOXB4	-9612.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
YY1	-8801.0
H2BC15	-8620.0
RBBP5	-8494.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
HOXA1	-7899.0
PAXIP1	-7318.0
EZH2	-6787.0
POLR2G	-6150.0
HOXB2	-6074.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
ASH2L	-5916.0
H2AZ2	-5775.0
H2BC11	-5756.0
PIAS2	-5746.0
MAFB	-5603.0
KMT2D	-5563.0
HOXA2	-5353.0
NCOR1	-5091.0
H3C2	-4876.0
POLR2H	-4815.0
AJUBA	-4514.0
HOXC4	-4394.0
POLR2L	-4064.0
HOXD1	-3757.0
WDR5	-3255.0
NCOA3	-3134.0
RBBP4	-3061.0
CTCF	-3026.0
POLR2I	-2974.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
RXRA	-2115.0
H2AC6	-2051.0
HOXD3	-1920.0
EP300	-1428.0
H4C5	-1423.0
CNOT6	-1349.0
H3-3A	-1342.0
POLR2F	-1161.0
H2BC5	-999.0
ZNF335	-963.0
EED	-862.0
POLR2A	-696.0
JUN	-686.0
H2BC12	-482.0
SUZ12	106.0
H4C3	423.0
PKNOX1	791.0
HOXB1	1101.0
CNOT9	1230.0
H4C16	1337.0
H2AJ	1704.0
HDAC3	1918.0
H2BC3	1965.0
MEIS1	2074.0
HOXD4	2173.0
H2BC21	2421.0
H2AZ1	2761.0
POLR2B	2810.0
PCGF2	2874.0
RARA	2942.0
RARB	3164.0
POLR2J	4123.0
CREBBP	4132.0
H4C2	4419.0
POLR2C	4579.0
NCOA6	4823.0
H3C3	4893.0
H2AC20	5150.0
EGR2	5545.0
H2BC14	6016.0
PAGR1	6279.0
H2BC1	6290.0
PBX1	6384.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
RARG	6965.0
POLR2D	6966.0
HOXA3	8407.0
HOXA4	8635.0
HOXB3	8888.0
H2AC14	9915.0

---

REACTOME_CILIUM_ASSEMBLY

REACTOME_CILIUM_ASSEMBLY

	902
set	REACTOME_CILIUM_ASSEMBLY
setSize	190
pANOVA	0.000164
s.dist	-0.159
p.adjustANOVA	0.00726

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBAL3	-10372
BBS1	-10355
TUBB2A	-10278
MKKS	-10154
EXOC1	-10055
DYNLL1	-10008
B9D1	-9979
ODF2	-9954
CCP110	-9836
CC2D2A	-9794
NPHP1	-9735
KIFAP3	-9713
IFT122	-9589
RPGRIP1L	-9569
TRIP11	-9508
IQCB1	-9429
BBS12	-9420
ARF4	-9333
ARL3	-9279
GBF1	-9104

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBAL3	-10372
BBS1	-10355
TUBB2A	-10278
MKKS	-10154
EXOC1	-10055
DYNLL1	-10008
B9D1	-9979
ODF2	-9954
CCP110	-9836
CC2D2A	-9794
NPHP1	-9735
KIFAP3	-9713
IFT122	-9589
RPGRIP1L	-9569
TRIP11	-9508
IQCB1	-9429
BBS12	-9420
ARF4	-9333
ARL3	-9279
GBF1	-9104
HAUS5	-9053
PKD2	-9029
CEP76	-9017
DYNLL2	-8918
CEP89	-8870
PRKACA	-8712
CCT2	-8511
EXOC5	-8488
TRAF3IP1	-8426
FBF1	-8352
KIF24	-8248
PLK4	-8111
HAUS6	-8080
DYNC2LI1	-8039
CDK5RAP2	-7957
CSNK1E	-7784
IFT81	-7757
DCTN2	-7732
NINL	-7514
WDR35	-7506
TUBB	-7392
KIF3C	-7310
CEP63	-7295
CEP152	-7092
DCTN3	-7069
DYNLRB1	-7059
BBS9	-6881
NEDD1	-6757
HSP90AA1	-6752
IFT52	-6504
CNTRL	-6497
DYNLT5	-6390
IFT46	-6285
DYNC2H1	-6200
IFT43	-6126
BBS4	-5936
EXOC4	-5931
DYNLT2	-5852
CENPJ	-5832
TUBB8	-5716
PCNT	-5487
NPHP3	-5457
NPHP4	-5398
DYNC2I1	-5313
IFT74	-5266
TTC8	-5258
EXOC6	-5165
HAUS4	-5164
TCP1	-4934
TMEM67	-4845
TUBG1	-4811
TUBB4A	-4807
BBS7	-4792
IFT22	-4752
IFT88	-4500
RAB3IP	-4456
PPP2R1A	-4275
TTC21B	-4256
MKS1	-4246
ASAP1	-4220
TNPO1	-4140
PCM1	-4085
MAPRE1	-4007
HAUS3	-3760
BBS10	-3611
AKAP9	-3477
HAUS1	-3468
CEP43	-3422
TCTN3	-3217
CEP164	-3164
C2CD3	-3158
TUBA1B	-2907
CEP70	-2853
TUBA1C	-2799
MCHR1	-2483
BBIP1	-2432
TTBK2	-2400
ARL13B	-2319
CEP72	-2259
TUBA8	-2181
IFT20	-2137
TUBA3C	-2009
MARK4	-1826
AHI1	-1800
CCT5	-1718
CCT8	-1236
WDR19	-1235
PAFAH1B1	-1210
B9D2	-1005
PRKAR2B	-934
YWHAG	-766
TUBA3E	-637
ACTR1A	-611
TUBB2B	-608
CYS1	-413
EXOC2	-296
CEP78	-180
EXOC3	-133
ALMS1	-87
RAB8A	4
CLASP1	104
ARL6	139
DCTN1	261
SDCCAG8	367
CSNK1D	501
CEP41	582
CDK1	604
CEP192	764
NEK2	796
CKAP5	1008
DYNLRB2	1421
DYNLT2B	1572
HAUS2	1587
TCTN1	1746
YWHAE	1817
IFT80	1931
CEP162	2060
CEP290	2164
IFT172	2379
SCLT1	2575
NDE1	2582
IFT27	2673
CEP135	2694
LZTFL1	2725
DYNC2I2	2839
PKD1	2845
TUBA4B	3110
TCTN2	3143
KIF17	3194
DYNC1I2	3247
RAB11A	3379
PLK1	3423
CNGA4	3548
DYNC1H1	3577
TUBB3	3736
BBS2	3950
KIF3A	4034
CCT4	4113
RHO	4176
HAUS8	4192
SFI1	4288
ATAT1	4328
CEP57	4409
UNC119B	4695
INPP5E	4698
IFT140	4812
RAB11FIP3	4852
EXOC8	4967
SSNA1	5028
EXOC7	5200
KIF3B	5304
TUBA4A	5567
CEP97	5602
PDE6D	5656
CEP250	5926
TUBA1A	6100
CLUAP1	6306
CCT3	6405
IFT57	6498
BBS5	6786
CEP131	6826
TUBB4B	6910
TUBB6	7030
SMO	7034
CEP83	7153
SSTR3	7616
TUBB1	7729
CNGB1	7915
TUBA3D	8852
TMEM216	9647

---

REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

	381
set	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX
setSize	85
pANOVA	0.000199
s.dist	-0.233
p.adjustANOVA	0.00861

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
PYGO1	-9986.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
PYGO1	-9986.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
RBBP5	-8494.0
AXIN2	-8451.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
H4C8	-5994.0
CDC73	-5992.0
H2BC26	-5963.0
TLE1	-5957.0
H2BC6	-5953.0
H4C1	-5951.0
ASH2L	-5916.0
H2AZ2	-5775.0
H2BC11	-5756.0
KMT2D	-5563.0
TLE4	-5289.0
BCL9	-5176.0
H3C2	-4876.0
TCF7	-3950.0
HDAC1	-3246.0
PYGO2	-3184.0
H4C4	-2969.0
H4C11	-2506.0
LEO1	-2458.0
H2BC4	-2161.0
H2AC6	-2051.0
EP300	-1428.0
H4C5	-1423.0
MEN1	-1348.0
H3-3A	-1342.0
H2BC5	-999.0
TLE3	-833.0
H2BC12	-482.0
LEF1	-58.0
H4C3	423.0
CTNNB1	601.0
H4C16	1337.0
MYC	1474.0
H2AJ	1704.0
H2BC3	1965.0
TLE2	1987.0
H3-4	2321.0
H2BC21	2421.0
TRRAP	2621.0
H2AZ1	2761.0
TCF4	3383.0
CREBBP	4132.0
TCF7L2	4369.0
H4C2	4419.0
TCF7L1	4753.0
H3C3	4893.0
H2AC20	5150.0
SMARCA4	5513.0
TERT	5815.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
KAT5	7650.0
RUNX3	9284.0
H2AC14	9915.0
BCL9L	10351.0

---

REACTOME_REPRODUCTION

REACTOME_REPRODUCTION

	114
set	REACTOME_REPRODUCTION
setSize	136
pANOVA	0.000236
s.dist	-0.183
p.adjustANOVA	0.00995

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TEX15	-10877.0
H2BC13	-10817.0
ADAM30	-10741.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
CATSPER3	-10327.0
H3C4	-10062.0
TOP3A	-9928.0
ZP2	-9923.0
H4C9	-9887.0
REC8	-9877.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TEX15	-10877.0
H2BC13	-10817.0
ADAM30	-10741.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
CATSPER3	-10327.0
H3C4	-10062.0
TOP3A	-9928.0
ZP2	-9923.0
H4C9	-9887.0
REC8	-9877.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
BRCA1	-9099.0
H3C11	-9013.0
MSH4	-8868.0
MRE11	-8696.0
H2BC15	-8620.0
ZP3	-8553.0
ADAM2	-8534.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
KCNU1	-7785.0
RBBP8	-7671.0
CDK4	-7529.0
CATSPERB	-7519.0
ATM	-7508.0
BRCA2	-7328.0
TERF2IP	-7165.0
CATSPERG	-7075.0
ACR	-6729.0
MLH1	-6596.0
SYCE3	-6558.0
CATSPER1	-6508.0
TINF2	-6451.0
RAD51	-6165.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
TERF2	-5913.0
H2AZ2	-5775.0
H2BC11	-5756.0
MLH3	-5618.0
H3C2	-4876.0
SPO11	-4713.0
SMC3	-4651.0
NBN	-4575.0
ATR	-4504.0
ADAM21	-3876.0
BLM	-3594.0
H4C4	-2969.0
H4C11	-2506.0
SYCP2	-2199.0
H2BC4	-2161.0
H2AC6	-2051.0
MND1	-1870.0
SYNE1	-1758.0
LMNA	-1442.0
STAG1	-1424.0
H4C5	-1423.0
H3-3A	-1342.0
ADAM20	-1261.0
SYNE2	-1194.0
H2BC5	-999.0
SUN1	-595.0
H2BC12	-482.0
ZP1	-346.0
RPA3	-298.0
POT1	-227.0
HSPA2	-223.0
FKBP6	47.0
H4C3	423.0
UBE2I	584.0
TEX12	994.0
PSMC3IP	1060.0
RAD50	1099.0
STAG3	1111.0
ZP4	1291.0
H4C16	1337.0
H2AJ	1704.0
SMC1B	1798.0
LMNB1	1840.0
CDK2	1892.0
TERF1	1919.0
H2BC3	1965.0
ACD	2104.5
H3-4	2321.0
MSH5	2404.0
H2BC21	2421.0
IZUMO2	2720.0
H2AZ1	2761.0
DIDO1	2794.0
OVGP1	3034.0
CATSPERD	3120.0
SYCP3	3255.0
SPAM1	3663.0
RAD21	3920.0
CATSPER2	4215.0
H4C2	4419.0
SUN2	4523.0
SYCE1	4551.0
SYCP1	4612.0
H3C3	4893.0
H2AC20	5150.0
IZUMO4	5226.0
SYCE2	5965.0
H2BC14	6016.0
RPA1	6175.0
H2BC1	6290.0
H3C1	6458.0
IZUMO1	6751.0
H4C6	6913.0
DMC1	6937.0
CD9	7032.0
CATSPER4	7494.0
RAD51C	7987.0
PRDM9	8445.0
HVCN1	8848.0
B4GALT1	9067.0
IZUMO3	9159.0
RPA2	9677.0
H2AC14	9915.0

---

REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP

REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP

	502
set	REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP
setSize	104
pANOVA	0.000297
s.dist	-0.205
p.adjustANOVA	0.0122

Top enriched genes

Top 20 genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
UBE2S	-10880.0
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
UBE2C	-9436.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
CDKN2B	-9096.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
CDKN2A	-8076.0
MAPK7	-7934.0
H4C13	-7923.0
H3C6	-7918.0
MAPK3	-7607.0
CDK4	-7529.0
FOS	-6639.0
RPS6KA1	-6373.0
ANAPC5	-6173.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
RPS27A	-5922.0
H2AZ2	-5775.0
H2BC11	-5756.0
UBB	-5278.0
H3C2	-4876.0
RPS6KA2	-4871.0
CEBPB	-4430.0
CCNA1	-4010.0
IGFBP7	-3651.0
NFKB1	-3646.0
ANAPC10	-3050.0
H4C4	-2969.0
H4C11	-2506.0
ANAPC11	-2468.0
UBE2D1	-2260.0
H2BC4	-2161.0
EHMT2	-2146.0
UBC	-2067.0
H2AC6	-2051.0
ANAPC4	-1807.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
JUN	-686.0
EHMT1	-638.0
CXCL8	-621.0
CDC16	-598.0
H2BC12	-482.0
IL1A	-391.0
CDC26	-126.0
CDKN1A	1.0
IL6	43.0
CCNA2	268.0
H4C3	423.0
CDK6	783.0
ANAPC7	838.0
H4C16	1337.0
RELA	1384.0
MAPK1	1551.0
CDC23	1666.0
H2AJ	1704.0
CDK2	1892.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
ANAPC2	2780.0
UBA52	2905.0
CDKN1B	3615.0
H4C2	4419.0
FZR1	4599.0
CDKN2C	4767.0
H3C3	4893.0
H2AC20	5150.0
CDC27	5348.0
ANAPC1	5774.0
ANAPC15	5844.0
H2BC14	6016.0
ANAPC16	6225.0
H2BC1	6290.0
H3C1	6458.0
UBE2E1	6712.0
H4C6	6913.0
STAT3	7142.0
VENTX	8480.0
H2AC14	9915.0
CDKN2D	10040.0

---

REACTOME_HCMV_EARLY_EVENTS

REACTOME_HCMV_EARLY_EVENTS

	1464
set	REACTOME_HCMV_EARLY_EVENTS
setSize	128
pANOVA	0.000331
s.dist	-0.184
p.adjustANOVA	0.0133

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
TUBB2A	-10278.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
TUBB2A	-10278.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
DYNLL2	-8918.0
H2BC15	-8620.0
TRIM28	-8574.0
H2AC13	-8341.0
H4C13	-7923.0
H3C6	-7918.0
CBX1	-7859.0
NDC1	-7758.0
NUP153	-7417.0
ITGB1	-7124.0
NUP50	-7103.0
EZH2	-6787.0
NUP35	-6340.0
H2AC17	-6215.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
NUP107	-5851.0
H2AC25	-5804.0
H2BC11	-5756.0
TUBB8	-5716.0
DYNC1LI1	-5413.0
H2AC15	-5344.0
NCOR1	-5091.0
H3C2	-4876.0
TUBB4A	-4807.0
NUP160	-4777.0
NUP93	-4202.0
RANBP2	-4186.0
NUP37	-4123.0
SEC13	-4109.0
POM121	-4065.0
NUP98	-3940.0
NUP88	-3822.0
H2AC11	-3666.0
NFKB1	-3646.0
NUP54	-3291.0
DYNC1I1	-3186.0
RBBP4	-3061.0
H4C4	-2969.0
TUBA1B	-2907.0
TUBA1C	-2799.0
TPR	-2693.0
NUP205	-2604.0
H4C11	-2506.0
TUBA8	-2181.0
H2BC4	-2161.0
NUP214	-2055.0
H2AC6	-2051.0
TUBA3C	-2009.0
DYNC1LI2	-1905.0
POM121C	-1851.0
H2AC16	-1553.0
TBL1XR1	-1458.0
H4C5	-1423.0
H2BC5	-999.0
EED	-862.0
H2AC21	-716.0
TUBA3E	-637.0
TUBB2B	-608.0
H2BC12	-482.0
SUZ12	106.0
H4C3	423.0
PML	823.0
NCOR2	927.0
EGFR	1128.0
H4C16	1337.0
AAAS	1385.0
NUP133	1721.0
NUP155	1883.0
HDAC3	1918.0
H2BC3	1965.0
NUP58	2106.0
H2BC21	2421.0
SEH1L	2648.0
TUBA4B	3110.0
DYNC1I2	3247.0
DYNC1H1	3577.0
RAE1	3695.0
TUBB3	3736.0
NUP188	4396.0
NUP42	4406.0
H4C2	4419.0
H2AC1	4742.0
H3C3	4893.0
H2AC20	5150.0
TUBA4A	5567.0
H2BC14	6016.0
TUBA1A	6100.0
NUP43	6107.0
H2BC1	6290.0
H3C1	6458.0
CREB1	6597.0
TUBB4B	6910.0
H4C6	6913.0
TUBB6	7030.0
DAXX	7214.0
TUBB1	7729.0
NUP210	7811.0
NUP62	7909.0
H2AC12	8376.0
TUBA3D	8852.0
GPS2	9588.0
H2AC14	9915.0

---

REACTOME_HCMV_INFECTION

REACTOME_HCMV_INFECTION

	1463
set	REACTOME_HCMV_INFECTION
setSize	152
pANOVA	0.000342
s.dist	-0.168
p.adjustANOVA	0.0134

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
CHMP4C	-10367.0
TUBB2A	-10278.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
TUBAL3	-10372.0
CHMP4C	-10367.0
TUBB2A	-10278.0
NUP85	-10122.0
H3C4	-10062.0
DYNLL1	-10008.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
DYNLL2	-8918.0
CHMP4B	-8724.0
H2BC15	-8620.0
TRIM28	-8574.0
H2AC13	-8341.0
H4C13	-7923.0
H3C6	-7918.0
CBX1	-7859.0
NDC1	-7758.0
NUP153	-7417.0
CEBPD	-7233.0
ITGB1	-7124.0
NUP50	-7103.0
CHMP1A	-6807.0
EZH2	-6787.0
VPS37D	-6738.0
NUP35	-6340.0
H2AC17	-6215.0
HNRNPK	-6138.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
CHMP4A	-5881.0
NUP107	-5851.0
H2AC25	-5804.0
H2BC11	-5756.0
TUBB8	-5716.0
DYNC1LI1	-5413.0
H2AC15	-5344.0
NCOR1	-5091.0
H3C2	-4876.0
TUBB4A	-4807.0
NUP160	-4777.0
NUP93	-4202.0
RANBP2	-4186.0
NUP37	-4123.0
SEC13	-4109.0
POM121	-4065.0
NUP98	-3940.0
NUP88	-3822.0
VPS37B	-3682.0
H2AC11	-3666.0
VPS37C	-3663.0
NFKB1	-3646.0
NUP54	-3291.0
DYNC1I1	-3186.0
RBBP4	-3061.0
H4C4	-2969.0
TUBA1B	-2907.0
TUBA1C	-2799.0
TPR	-2693.0
NUP205	-2604.0
H4C11	-2506.0
CHMP2A	-2484.0
CHMP7	-2480.0
TUBA8	-2181.0
H2BC4	-2161.0
NUP214	-2055.0
H2AC6	-2051.0
TUBA3C	-2009.0
DYNC1LI2	-1905.0
TSG101	-1904.0
POM121C	-1851.0
VPS4A	-1614.0
H2AC16	-1553.0
TBL1XR1	-1458.0
H4C5	-1423.0
H2BC5	-999.0
EED	-862.0
H2AC21	-716.0
TUBA3E	-637.0
TUBB2B	-608.0
H2BC12	-482.0
VPS25	-336.0
SUZ12	106.0
H4C3	423.0
VPS37A	642.0
PML	823.0
NCOR2	927.0
MVB12B	928.0
EGFR	1128.0
H4C16	1337.0
AAAS	1385.0
NUP133	1721.0
NUP155	1883.0
HDAC3	1918.0
H2BC3	1965.0
MVB12A	1966.0
CHMP3	1967.0
NUP58	2106.0
H2BC21	2421.0
SEH1L	2648.0
TUBA4B	3110.0
DYNC1I2	3247.0
VPS28	3267.0
VPS36	3426.0
DYNC1H1	3577.0
RAE1	3695.0
TUBB3	3736.0
UBAP1	4024.0
NUP188	4396.0
NUP42	4406.0
H4C2	4419.0
H2AC1	4742.0
H3C3	4893.0
H2AC20	5150.0
TUBA4A	5567.0
H2BC14	6016.0
TUBA1A	6100.0
NUP43	6107.0
H2BC1	6290.0
H3C1	6458.0
CREB1	6597.0
CHMP6	6620.0
TUBB4B	6910.0
H4C6	6913.0
CHMP2B	6950.0
TUBB6	7030.0
DAXX	7214.0
SNF8	7597.0
TUBB1	7729.0
NUP210	7811.0
NUP62	7909.0
H2AC12	8376.0
TUBA3D	8852.0
GPS2	9588.0
H2AC14	9915.0

---

REACTOME_RHO_GTPASES_ACTIVATE_PKNS

REACTOME_RHO_GTPASES_ACTIVATE_PKNS

	915
set	REACTOME_RHO_GTPASES_ACTIVATE_PKNS
setSize	86
pANOVA	0.000354
s.dist	-0.223
p.adjustANOVA	0.0135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
YWHAB	-10128.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PAK1	-9451.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
YWHAB	-10128.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
PAK1	-9451.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
YWHAQ	-9275.0
H3C11	-9013.0
H2BC15	-8620.0
PKN3	-8308.0
H2AX	-8295.0
H3-3B	-8282.0
RHOC	-8220.0
H4C13	-7923.0
H3C6	-7918.0
PPP1R12A	-7391.0
KDM4C	-6407.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
YWHAH	-5939.0
H2AZ2	-5775.0
H2BC11	-5756.0
KLK3	-4993.0
H3C2	-4876.0
RAC1	-3237.0
H4C4	-2969.0
H4C11	-2506.0
PDPK1	-2363.0
MYH14	-2346.0
NCOA2	-2193.0
H2BC4	-2161.0
YWHAZ	-2100.0
H2AC6	-2051.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
MYL6	-913.0
YWHAG	-766.0
H2BC12	-482.0
PKN2	-214.0
H4C3	423.0
MYH11	440.0
PPP1R12B	442.0
MYH10	778.0
RHOA	920.0
CDC25C	1212.0
H4C16	1337.0
KDM1A	1556.0
H2AJ	1704.0
YWHAE	1817.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
MYL12B	2820.0
H4C2	4419.0
H3C3	4893.0
KLK2	4985.0
H2AC20	5150.0
PPP1CB	5293.0
H2BC14	6016.0
H2BC1	6290.0
H3C1	6458.0
PKN1	6503.0
MYH9	6542.0
H4C6	6913.0
PPP1R14A	7492.0
RHOB	8926.0
MYL9	9010.0
SFN	9832.0
H2AC14	9915.0

---

REACTOME_INFECTIOUS_DISEASE

REACTOME_INFECTIOUS_DISEASE

	974
set	REACTOME_INFECTIOUS_DISEASE
setSize	910
pANOVA	0.000361
s.dist	-0.0697
p.adjustANOVA	0.0135

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STING1	-11280.0
IFNA16	-11111.0
GNAS	-11071.0
GEMIN6	-11067.0
GEMIN2	-11040.0
CD79B	-11039.0
CTSL	-11021.0
IL1B	-10950.0
IFNA2	-10939.0
PSTPIP1	-10937.0
H2BC13	-10817.0
GNAI1	-10788.0
MAP2K1	-10776.0
H2BC10	-10719.0
RPL23	-10697.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
RPL39L	-10606.0
H3C8	-10552.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STING1	-11280.0
IFNA16	-11111.0
GNAS	-11071.0
GEMIN6	-11067.0
GEMIN2	-11040.0
CD79B	-11039.0
CTSL	-11021.0
IL1B	-10950.0
IFNA2	-10939.0
PSTPIP1	-10937.0
H2BC13	-10817.0
GNAI1	-10788.0
MAP2K1	-10776.0
H2BC10	-10719.0
RPL23	-10697.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
RPL39L	-10606.0
H3C8	-10552.0
RIGI	-10533.0
IFNA21	-10453.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
TUBAL3	-10372.0
CHMP4C	-10367.0
RB1	-10297.0
RPS10	-10283.0
TUBB2A	-10278.0
GNG8	-10248.0
FCGR2A	-10233.0
JAK3	-10219.0
GEMIN7	-10182.0
PPIG	-10171.0
SFTPD	-10145.0
YWHAB	-10128.0
NUP85	-10122.0
VEGFA	-10112.0
SERPINE1	-10104.0
H3C4	-10062.0
IFNAR2	-10016.0
RPL6	-10014.0
GNGT1	-10012.0
DYNLL1	-10008.0
GNG10	-10006.0
CBL	-9998.0
PARP14	-9951.0
H4C9	-9887.0
GRSF1	-9886.0
H4C12	-9845.0
IL17RA	-9812.0
HMGA1	-9808.0
RPS9	-9761.0
PSMD8	-9717.0
H2AC8	-9679.0
PSMC6	-9675.0
RPL4	-9642.0
FKBP4	-9610.0
GNG11	-9609.0
H2BC8	-9584.0
RPL3	-9583.0
KPNA7	-9535.0
TXNIP	-9525.0
H2BC17	-9503.0
SNRPB	-9483.0
H3C10	-9467.0
PSMD14	-9466.0
NT5E	-9425.0
ISG15	-9405.0
H2BC9	-9375.5
H3C7	-9375.5
CTDP1	-9365.0
TLR1	-9346.0
H2AC4	-9326.0
ELMO2	-9290.0
YWHAQ	-9275.0
GUCY2C	-9251.0
PSMC3	-9217.0
PARP1	-9214.0
PARP8	-9196.0
XPO1	-9161.0
PSMA7	-9072.0
TXN	-9040.0
NPM1	-9022.0
H3C11	-9013.0
SAP30	-9007.0
GTF2F1	-8995.0
CSNK1A1	-8958.0
CTNND1	-8956.0
SIKE1	-8928.0
KPNA5	-8922.0
DYNLL2	-8918.0
PSMD9	-8887.0
PPIA	-8875.0
VPS16	-8807.0
PSMA6	-8781.0
GTF2A1	-8765.0
PSMB10	-8751.0
CHMP4B	-8724.0
PRKACA	-8712.0
IFNA1	-8684.0
H2BC15	-8620.0
RPL13	-8609.0
TRIM28	-8574.0
PSMC2	-8506.0
MAP2K4	-8500.0
RAB5A	-8428.0
TAF3	-8410.0
RPL17	-8398.0
EDEM2	-8395.0
FXYD7	-8386.0
IFNA14	-8378.0
H2AC13	-8341.0
PSMB11	-8322.0
CXCR4	-8307.0
FNTA	-8301.0
ZCRB1	-8277.0
GNAI3	-8276.0
PRKACG	-8257.0
RPS23	-8097.0
LIG4	-8095.0
GTF2A2	-8087.0
GNG4	-8043.0
IMPDH1	-8007.0
SDC1	-7963.0
TAF11	-7947.0
H4C13	-7923.0
H3C6	-7918.0
WASF1	-7901.0
RPS20	-7897.0
CBLL1	-7889.0
CBX1	-7859.0
ADCY4	-7838.0
IPO5	-7835.0
PSMF1	-7828.0
ERCC3	-7795.0
TAF13	-7780.0
TLR2	-7770.0
NDC1	-7758.0
ZDHHC2	-7711.0
RIPK2	-7686.0
DNAJC3	-7682.0
ITGA4	-7639.0
MAP2K2	-7626.0
PSMB3	-7613.0
MAPK3	-7607.0
ZDHHC3	-7563.0
MAN2A1	-7495.0
ELMO1	-7490.0
MAP1LC3B	-7470.0
RPN2	-7445.0
HBEGF	-7429.0
NUP153	-7417.0
SRPK2	-7404.0
IFIH1	-7403.0
TUBB	-7392.0
CD4	-7354.0
RPS26	-7342.0
WIPF1	-7336.0
PDCD6IP	-7324.0
IFNA6	-7323.0
RPL37	-7268.0
WASL	-7241.0
RPS27L	-7238.0
TBK1	-7236.0
CEBPD	-7233.0
RPL11	-7228.0
ST3GAL3	-7182.0
FXYD2	-7173.0
BCL2L1	-7168.0
ITGB1	-7124.0
SOS1	-7110.0
NUP50	-7103.0
STX1A	-7100.0
ATP1B1	-7070.0
BRK1	-7045.0
ADAM17	-7015.0
RPS12	-6965.0
PSMA4	-6953.0
ARPC3	-6943.0
YES1	-6925.0
SKP1	-6898.0
CHMP1A	-6807.0
EZH2	-6787.0
HSP90AA1	-6752.0
GNG2	-6750.0
VPS37D	-6738.0
PSMB8	-6727.0
FXYD4	-6721.0
RPL26	-6681.0
MAPK8	-6659.0
EPS15	-6654.0
SNRPD1	-6623.0
CCNT2	-6619.0
NOD1	-6604.0
KPNA3	-6592.0
NFKB2	-6591.0
FGR	-6590.0
GJA1	-6588.0
MBD3	-6559.0
TUFM	-6501.0
PSMB1	-6458.0
CYBA	-6447.0
VCP	-6433.0
ABI2	-6431.0
TGFB1	-6399.0
LIG1	-6397.0
DDX5	-6380.0
NCKAP1L	-6352.0
NUP35	-6340.0
GNB4	-6331.0
TAF2	-6310.0
PTPN11	-6297.0
TRIM27	-6295.0
DVL1	-6273.0
CDK7	-6225.0
H2AC17	-6215.0
GNB2	-6210.0
GNAT3	-6176.0
SDC2	-6172.0
POLR2G	-6150.0
HNRNPK	-6138.0
RCC1	-6013.0
H4C8	-5994.0
NRP1	-5990.0
MGAT4A	-5989.0
VTA1	-5982.0
NFE2L2	-5975.0
H2BC26	-5963.0
SUPT16H	-5961.0
H2BC6	-5953.0
H4C1	-5951.0
YWHAH	-5939.0
RPS27A	-5922.0
CHMP4A	-5881.0
NOD2	-5861.0
NUP107	-5851.0
H2AC25	-5804.0
VPS39	-5761.0
H2BC11	-5756.0
TAF1L	-5747.0
GGT1	-5719.0
TUBB8	-5716.0
ELOC	-5705.0
VPS41	-5684.0
BTRC	-5601.0
SNRPG	-5578.0
DVL2	-5575.0
KPNB1	-5545.0
CCNT1	-5531.0
PRKAR1A	-5512.0
ST3GAL4	-5494.0
MGAT5	-5483.0
SUDS3	-5467.0
PSMD4	-5443.0
STAM	-5438.0
DYNC1LI1	-5413.0
PRKAR1B	-5394.0
RPS16	-5355.0
H2AC15	-5344.0
NOXA1	-5341.0
ENTPD5	-5338.0
PSMB5	-5303.0
CALR	-5288.0
UBB	-5278.0
GTF2B	-5265.0
ANO6	-5173.0
RPL30	-5126.0
ATG14	-5116.0
NCOR1	-5091.0
WNT5A	-5085.0
CYSLTR2	-5079.0
RNMT	-5078.0
PSMA3	-5040.0
VPS11	-5035.0
FZD7	-5001.0
TAF4	-4973.0
H3C2	-4876.0
RUNX1	-4859.0
RPL22L1	-4844.0
POLR2H	-4815.0
GTF2H5	-4812.0
TUBB4A	-4807.0
HSPA1A	-4799.0
CALM1	-4778.0
NUP160	-4777.0
SAR1B	-4680.0
RPS28	-4667.0
GGT5	-4661.0
SP1	-4636.0
RPL18	-4599.0
PIK3R4	-4595.0
PLCG2	-4592.0
FKBP1A	-4577.0
ARPC1A	-4527.0
RPL37A	-4494.0
TAB1	-4468.0
MNAT1	-4434.0
PARP4	-4407.0
ROCK1	-4395.0
RPS6	-4391.0
WASF2	-4386.0
HCK	-4367.0
RPSA	-4359.0
BANF1	-4346.0
AP1M2	-4314.0
KPNA4	-4243.0
SEC24B	-4239.0
TAB2	-4238.0
NUP93	-4202.0
RANBP2	-4186.0
ARF1	-4184.0
CLTC	-4177.0
DVL3	-4170.0
NUP37	-4123.0
GNG12	-4121.0
SEC13	-4109.0
RPL27	-4094.0
ARID4B	-4090.0
POM121	-4065.0
POLR2L	-4064.0
GSK3B	-4058.0
NMI	-4017.0
GTF2F2	-4002.0
SUPT4H1	-4001.0
ACTG1	-3986.0
NUP98	-3940.0
GPC5	-3929.0
NELFE	-3914.0
VPS45	-3859.0
RPLP2	-3834.0
NUP88	-3822.0
GSK3A	-3813.0
ATP1A3	-3782.0
RPL13A	-3764.5
HMOX1	-3692.0
CUL5	-3691.0
VPS37B	-3682.0
GALNT1	-3672.0
H2AC11	-3666.0
VPS37C	-3663.0
NFKB1	-3646.0
PRMT1	-3642.0
RPS15A	-3600.0
SEC23A	-3585.0
PLK2	-3578.0
ATP1B3	-3549.0
SFPQ	-3542.0
S1PR1	-3529.0
TAF4B	-3511.0
FURIN	-3491.0
SNRPD2	-3471.0
GSDMD	-3421.0
ITPR2	-3392.0
EIF2AK2	-3360.0
RPL12	-3302.0
NUP54	-3291.0
MEFV	-3283.0
RNGTT	-3274.0
SMAD3	-3269.0
HDAC1	-3246.0
RAC1	-3237.0
FUT8	-3224.0
RPL41	-3199.0
PSMB7	-3196.0
NLRP3	-3194.0
DYNC1I1	-3186.0
ACTB	-3090.0
STAT2	-3084.0
RBBP4	-3061.0
MAPK14	-3056.0
PSMA1	-3041.0
ADORA2B	-3014.0
POLR2I	-2974.0
H4C4	-2969.0
SYT1	-2966.0
CHMP5	-2921.0
TUBA1B	-2907.0
IRF3	-2859.0
PPIB	-2822.0
RPL22	-2808.0
TUBA1C	-2799.0
RPS15	-2797.0
SYT2	-2754.0
WASF3	-2730.0
RPL27A	-2722.0
TPR	-2693.0
MYO5A	-2667.0
NUP205	-2604.0
PSMC5	-2598.0
SYK	-2585.0
DDX20	-2580.0
STAM2	-2574.0
SEC24C	-2567.0
PSMD7	-2547.0
CANX	-2541.0
STT3A	-2507.0
H4C11	-2506.0
PHF21A	-2500.0
AP2M1	-2486.0
CHMP2A	-2484.0
CHMP7	-2480.0
CRB3	-2463.0
GEMIN4	-2447.0
NCKAP1	-2444.0
IFNGR2	-2394.0
PDPK1	-2363.0
CD163	-2362.0
G3BP1	-2355.0
RPL5	-2353.0
ZDHHC5	-2336.0
HNRNPA1	-2312.0
PLCG1	-2298.0
TUSC3	-2278.0
TUBA8	-2181.0
KPNA1	-2173.0
H2BC4	-2161.0
PTK2	-2119.0
YWHAZ	-2100.0
UBC	-2067.0
NUP214	-2055.0
H2AC6	-2051.0
UBE2N	-2050.0
RPL35A	-2036.0
FCGR3A	-2035.0
GPC6	-2025.0
TUBA3C	-2009.0
NCBP2	-1986.0
MET	-1981.0
ADCY3	-1924.0
SUGT1	-1911.0
DYNC1LI2	-1905.0
TSG101	-1904.0
ITCH	-1877.0
XRCC6	-1860.0
VPS18	-1854.0
POM121C	-1851.0
NEDD4L	-1832.0
ADCY2	-1831.0
RPL7	-1829.0
CDC42	-1774.0
RPS7	-1770.0
TAF9	-1757.0
SMN1	-1725.5
SMN2	-1725.5
SH3GL2	-1679.0
GNG5	-1641.0
VPS4A	-1614.0
ATP6V1H	-1607.0
ANTXR1	-1584.0
H2AC16	-1553.0
RPL38	-1552.0
ARID4A	-1540.0
RHBDF2	-1538.0
PTGES3	-1522.0
TBL1XR1	-1458.0
RPLP1	-1436.0
EP300	-1428.0
H4C5	-1423.0
BRMS1	-1404.0
CRBN	-1350.0
ANTXR2	-1327.0
LARP1	-1319.0
PPIH	-1240.0
CDH1	-1212.0
ROCK2	-1183.0
HSP90AB1	-1174.0
POLR2F	-1161.0
CCNH	-1145.0
RANGAP1	-1144.0
GPC2	-1137.0
PSMB6	-1085.0
MAP2K7	-1008.0
SH3GL1	-1003.0
H2BC5	-999.0
PSMA5	-964.0
C3	-953.0
PSMB4	-949.0
ITPR1	-948.0
IL17RC	-946.0
PRKAR2B	-934.0
NCK1	-922.0
EED	-862.0
WIPF2	-826.0
YWHAG	-766.0
PSIP1	-749.0
CRK	-734.0
PIK3C3	-723.0
FYN	-717.0
H2AC21	-716.0
PSMA2	-698.0
POLR2A	-696.0
JUN	-686.0
MAN1B1	-684.0
TXNRD1	-647.0
ANO3	-639.0
TUBA3E	-637.0
VAV1	-625.0
TUBB2B	-608.0
CCNK	-584.0
CHUK	-484.0
H2BC12	-482.0
PSMD2	-461.0
PSMD6	-450.0
PSMD1	-441.0
GEMIN5	-414.0
IL1A	-391.0
PAK2	-377.0
XRCC4	-358.0
HLA-B	-344.0
GNAI2	-343.0
VPS25	-336.0
AKT3	-289.0
MYO10	-271.0
MYO1C	-267.0
RBX1	-261.0
HGS	-220.0
SRC	-215.0
RNF213	-202.0
GTF2H1	-188.0
CD79A	-121.0
RPS18	-119.0
ARPC2	-51.0
PSMD11	-47.0
IL6	43.0
CDK9	48.0
RPS14	100.0
SUZ12	106.0
FXYD3	185.0
NR3C1	227.0
PSME3	308.0
PKLR	309.0
B2M	357.0
NELFB	359.0
MAP3K7	364.0
NELFA	403.0
DAD1	414.0
H4C3	423.0
RPL34	464.0
NMT1	470.0
RPL21	477.0
ST3GAL2	484.0
ATP1A4	560.0
TBP	561.0
TOMM70	567.0
BST2	581.0
UBE2I	584.0
CTNNB1	601.0
VPS37A	642.0
PSMB9	675.0
PARP9	678.0
FNTB	685.0
ANO10	687.0
AP1G1	705.0
STX1B	730.0
MAP2K6	747.0
RPS21	801.0
SUMO1	802.0
SNAP25	810.0
PRKACB	818.0
SLC25A4	821.0
PML	823.0
NCOR2	927.0
MVB12B	928.0
ANO4	995.0
PSMD5	1121.0
EGFR	1128.0
PATJ	1129.0
CYFIP1	1145.0
GTF2E2	1185.0
TRAF6	1231.0
HLA-A	1249.0
TAF6	1262.0
ST6GALNAC2	1284.0
H4C16	1337.0
RELA	1384.0
AAAS	1385.0
REST	1451.0
MAVS	1498.0
PSMD12	1518.0
VPS4B	1528.0
MAPK1	1551.0
KDM1A	1556.0
RPS11	1577.0
ABL1	1646.0
ZBP1	1658.0
SV2C	1678.0
RPL8	1720.0
NUP133	1721.0
SNRPD3	1725.0
SSRP1	1806.0
PSMD13	1814.0
YWHAE	1817.0
RPN1	1855.0
SAP18	1866.0
ARPC4	1875.0
NUP155	1883.0
HDAC3	1918.0
H2BC3	1965.0
MVB12A	1966.0
CHMP3	1967.0
AP2A1	1983.0
PSMC4	1992.0
PACS1	2025.0
IL18	2064.0
SEC24D	2095.0
NUP58	2106.0
CUL3	2108.0
PALS1	2117.0
UBE2V1	2118.0
IMPDH2	2184.0
EEF1A1	2194.0
ACTR3	2195.0
NLRP12	2225.0
RPS5	2306.0
HMG20B	2307.0
HAVCR1	2313.0
AHCYL1	2328.0
GNG13	2411.0
H2BC21	2421.0
GOLGA7	2433.0
SMAD4	2454.0
RIPK1	2479.0
PSMD3	2572.0
CPSF4	2598.0
SEH1L	2648.0
PSMB2	2710.0
RPL24	2722.0
ZDHHC20	2744.0
ELL	2755.0
POLR2B	2810.0
NMT2	2817.0
CNBP	2826.0
VAV3	2835.0
TAF15	2884.0
UBA52	2905.0
ANO5	2947.0
TJP1	2956.0
VPS33A	2973.0
TAF12	2983.0
UVRAG	3024.0
RPL32	3032.0
RPL26L1	3044.0
RPLP0	3047.0
MTA1	3060.0
ISCU	3082.0
TRIM4	3086.0
MGAT4C	3097.0
TUBA4B	3110.0
ST3GAL1	3170.0
HLA-C	3192.0
RPL9	3195.0
RPS19	3242.0
DYNC1I2	3247.0
VPS28	3267.0
RPL31	3289.0
TRAF3	3337.0
SDC3	3347.0
NCKIPSD	3374.0
KPNA2	3395.0
VPS36	3426.0
G3BP2	3441.0
CYFIP2	3456.0
TAF5	3532.0
PSMC1	3545.0
RCAN3	3546.0
P2RX7	3566.0
DYNC1H1	3577.0
AP1M1	3603.0
CHD4	3616.0
ADCY6	3629.0
GTF2E1	3630.0
RPS3A	3651.0
STAT1	3655.0
ATP1B2	3669.0
RAE1	3695.0
TUBB3	3736.0
CAV1	3754.0
SH3GL3	3759.0
AP2B1	3761.0
PYCARD	3769.0
IRF7	3799.0
PSME4	3824.0
AKT2	3850.0
DPEP1	3873.0
GATAD2B	3897.0
FXYD6	3926.0
PABPN1	4016.0
UBAP1	4024.0
PARP6	4025.0
SV2B	4029.0
AP2A2	4033.0
TKFC	4095.0
ARPC5	4114.0
POLR2J	4123.0
CREBBP	4132.0
EEF2	4148.0
JAK1	4160.0
RAN	4175.0
DOCK2	4179.0
CD3G	4210.0
RPL10L	4242.0
DDOST	4283.0
SV2A	4307.0
DOCK1	4377.0
NUP188	4396.0
ZDHHC11	4397.0
CD247	4400.0
NUP42	4406.0
RPS29	4414.0
H4C2	4419.0
ELOB	4422.0
NCBP1	4442.0
PRKCSH	4458.0
PSME2	4493.0
RPS27	4496.0
PARP16	4497.0
RPL28	4510.0
GPC1	4545.0
POLR2C	4579.0
BAIAP2	4598.0
GTF2H4	4615.0
SUPT5H	4635.0
RPS3	4667.0
IKBKB	4680.0
GNB1	4690.0
MASP2	4739.0
H2AC1	4742.0
ADCY1	4774.0
PRKAR2A	4789.0
GNB5	4873.0
PSMA8	4885.0
GNG7	4891.0
H3C3	4893.0
MTA3	4897.0
TYK2	4921.0
SEC24A	4933.0
RPS13	4948.0
ACTR2	4966.0
CLTA	4993.0
SNRPF	5009.0
MAP2K3	5017.0
KEAP1	5065.0
AP1S1	5093.0
RPL7A	5102.0
XRCC5	5142.0
H2AC20	5150.0
ADCY8	5156.0
RPS25	5161.0
NFKBIA	5163.0
HLA-E	5175.0
SRPK1	5178.0
RIPK3	5201.0
GTF2H3	5292.0
TMPRSS2	5339.0
GANAB	5347.0
IFNA13	5349.0
CORO1A	5405.0
TUBA4A	5567.0
TRIM25	5607.0
SAP30L	5623.0
MASP1	5632.0
AKT1	5667.0
NOS2	5737.0
ELOA2	5752.0
ELOA	5760.0
C3AR1	5792.0
ITPR3	5809.0
WIPF3	5813.0
ADCY7	5820.0
VHL	5824.0
ABI1	5836.0
ST6GALNAC3	5840.0
ANO9	5876.0
RPL18A	5878.0
APP	5881.0
HSPG2	5882.0
NOXO1	5935.0
PCBP2	5938.0
H2BC14	6016.0
RPS2	6067.0
RANBP1	6094.0
TUBA1A	6100.0
NUP43	6107.0
MGAT1	6130.0
HDAC2	6155.0
RCOR1	6193.0
GATAD2A	6214.0
CD8B	6230.0
IL1R1	6280.0
MGAT2	6285.5
RPL36AL	6285.5
H2BC1	6290.0
PSME1	6314.0
CASP1	6316.0
ADCY9	6321.0
IL6R	6346.0
LYN	6357.0
VPS33B	6381.0
H3C1	6458.0
IL10	6509.0
POLR2E	6530.0
MYH9	6542.0
CREB1	6597.0
CHMP6	6620.0
ANO1	6648.0
VAMP2	6666.0
SDC4	6670.0
RPL19	6671.0
RPL14	6785.0
AP1B1	6903.0
TUBB4B	6910.0
H4C6	6913.0
CHMP2B	6950.0
IFNAR1	6955.0
POLR2D	6966.0
RAB7A	6971.0
MOGS	6972.0
FAU	6980.0
ANO8	7006.0
TUBB6	7030.0
CD9	7032.0
RPL23A	7062.0
IKBKE	7074.0
CCR5	7083.0
RPL15	7171.0
MBL2	7202.0
DAXX	7214.0
JAK2	7276.0
BECN1	7340.0
SIGMAR1	7383.0
AP1S3	7393.0
SNRPE	7418.0
AGRN	7485.0
HLA-G	7563.0
MYH2	7580.0
SNF8	7597.0
ERCC2	7598.0
BLNK	7599.0
P2RX4	7602.0
IFNGR1	7611.0
COMT	7654.0
GNAZ	7691.0
TUBB1	7729.0
VAMP1	7742.0
RPS8	7774.0
VAV2	7788.0
GNG3	7803.0
NUP210	7811.0
ST6GAL1	7856.0
IL17A	7872.0
LTF	7905.0
NUP62	7909.0
FEN1	7913.0
ADCY5	7951.0
DUSP16	7955.0
ANO2	7961.0
IRAK2	8025.0
RPL3L	8039.0
CD28	8117.0
LCK	8280.0
CHD3	8284.0
MYO9B	8285.0
GNB3	8333.0
TLR9	8366.0
H2AC12	8376.0
PDCD1	8382.0
RPL29	8421.0
TCEA1	8431.0
CTSG	8446.0
MTA2	8453.0
ATP1A1	8534.0
ATP1A2	8668.0
HLA-F	8802.0
TUBA3D	8852.0
ARPC1B	8864.0
ANO7	8904.0
MGAT4B	8949.0
RPL10A	9024.0
PARP10	9087.0
FXYD1	9131.0
IL17F	9150.0
ENTPD1	9161.0
RPL35	9213.0
ST6GALNAC4	9308.0
GRB2	9310.0
TAF10	9342.0
SEM1	9392.0
RPS24	9490.0
AP2S1	9534.0
BRD4	9578.0
GPS2	9588.0
RNF135	9664.0
IFNB1	9714.0
ENO1	9815.0
SFN	9832.0
ZDHHC8	9846.0
RPL36	9849.0
NELFCD	9891.0
H2AC14	9915.0
TAF7	9925.0
APOBEC3G	9972.0
IFNA5	10215.0
GNGT2	10321.0
DPEP2	10347.0
DPEP3	10375.0
IFNA7	10388.0
PTPN6	10472.0
IFNA8	10507.0

---

REACTOME_METABOLISM_OF_RNA

REACTOME_METABOLISM_OF_RNA

	1313
set	REACTOME_METABOLISM_OF_RNA
setSize	675
pANOVA	0.000373
s.dist	-0.0803
p.adjustANOVA	0.0136

Top enriched genes

Top 20 genes

GeneID	Gene Rank
THOC3	-11116
GEMIN6	-11067
GEMIN2	-11040
TYW1	-10735
RPL23	-10697
RPL39L	-10606
SNU13	-10583
GTPBP3	-10523
UTP20	-10478
APOBEC2	-10455
POLR2K	-10397
RPS10	-10283
GEMIN7	-10182
PPIG	-10171
YWHAB	-10128
NUP85	-10122
ERI1	-10025
RPL6	-10014
WDR43	-9880
MRM2	-9787

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
THOC3	-11116.0
GEMIN6	-11067.0
GEMIN2	-11040.0
TYW1	-10735.0
RPL23	-10697.0
RPL39L	-10606.0
SNU13	-10583.0
GTPBP3	-10523.0
UTP20	-10478.0
APOBEC2	-10455.0
POLR2K	-10397.0
RPS10	-10283.0
GEMIN7	-10182.0
PPIG	-10171.0
YWHAB	-10128.0
NUP85	-10122.0
ERI1	-10025.0
RPL6	-10014.0
WDR43	-9880.0
MRM2	-9787.0
RPS9	-9761.0
PSMD8	-9717.0
EXOSC5	-9710.0
PSMC6	-9675.0
AQR	-9667.0
RPL4	-9642.0
HNRNPR	-9636.0
RPL3	-9583.0
SRSF9	-9561.0
MPHOSPH10	-9557.0
APOBEC1	-9549.0
WDR4	-9542.0
ZC3H11A	-9520.0
SNRPB	-9483.0
PSMD14	-9466.0
EIF4A2	-9465.0
BCAS2	-9428.0
RPP30	-9403.0
PSMC3	-9217.0
WDR75	-9201.0
HEATR1	-9180.0
XPO1	-9161.0
UTP4	-9141.0
RTCB	-9123.0
WDR36	-9120.0
FCF1	-9101.0
PSMA7	-9072.0
GTF2F1	-8995.0
PSMD9	-8887.0
PSMA6	-8781.0
CDKAL1	-8771.0
PSMB10	-8751.0
NIP7	-8747.0
SMU1	-8716.0
WDR70	-8714.0
PNO1	-8627.0
RPL13	-8609.0
PSMC2	-8506.0
RPL17	-8398.0
TRNT1	-8393.0
TRIT1	-8374.0
PSMB11	-8322.0
ZCRB1	-8277.0
NOP56	-8259.0
TRA2B	-8175.0
TRMT12	-8141.0
FAM98B	-8112.0
CPSF6	-8104.0
RPS23	-8097.0
ACIN1	-8065.0
CPSF2	-8062.0
IGF2BP1	-8026.0
EIF4A1	-8021.0
BUD31	-7962.0
C9orf78	-7958.0
RPS20	-7897.0
NSUN6	-7894.0
THUMPD1	-7890.0
PDCD7	-7863.0
RPP40	-7852.0
PSMF1	-7828.0
ERCC3	-7795.0
CSNK1E	-7784.0
NDC1	-7758.0
RPPH1	-7693.0
WDR12	-7672.0
QTRT2	-7620.0
PSMB3	-7613.0
PRMT5	-7574.0
THOC1	-7547.0
BUD13	-7525.0
UTP6	-7502.0
PRPF31	-7446.0
SNRPA	-7439.0
NUP153	-7417.0
ALYREF	-7406.0
DIS3	-7387.0
CSTF3	-7348.0
RPS26	-7342.0
RPL37	-7268.0
CASC3	-7261.0
DDX23	-7244.0
RPS27L	-7238.0
RPL11	-7228.0
FIP1L1	-7227.0
FBL	-7221.0
NOL11	-7194.0
YJU2	-7145.0
RRP9	-7109.0
NUP50	-7103.0
SART1	-7057.0
APOBEC3C	-7050.0
RPS12	-6965.0
SNUPN	-6961.0
PSMA4	-6953.0
SF3B5	-6946.0
UTP25	-6928.0
EIF4B	-6916.0
ANP32A	-6908.0
SYF2	-6905.0
WBP4	-6800.0
SRSF6	-6777.0
IMP4	-6764.0
OSGEP	-6730.0
PSMB8	-6727.0
DDX46	-6699.0
RPL26	-6681.0
LTV1	-6675.0
CNOT2	-6646.0
SNRPD1	-6623.0
WDR18	-6612.0
TRMT11	-6557.0
TRMT112	-6520.0
ADAT2	-6512.0
PAN2	-6494.0
PSMB1	-6458.0
PNRC2	-6401.0
DDX5	-6380.0
RIOK2	-6344.0
NUP35	-6340.0
CNOT1	-6330.0
CWF19L2	-6258.0
CDK7	-6225.0
SMNDC1	-6167.0
POLR2G	-6150.0
SRSF10	-6139.0
HNRNPK	-6138.0
PABPC1	-6124.0
MAGOHB	-6119.0
CHTOP	-6070.0
IK	-6027.0
LSM6	-5977.0
RPS27A	-5922.0
SF3B2	-5906.0
NUP107	-5851.0
FAM32A	-5837.0
KRR1	-5773.0
PHF5A	-5633.0
EFTUD2	-5630.0
RPP25	-5605.0
SNRPG	-5578.0
MTREX	-5573.0
CPSF7	-5495.0
TSEN15	-5492.0
PSMD4	-5443.0
ISY1	-5387.0
DDX49	-5382.0
RPS16	-5355.0
PUS3	-5346.0
POP7	-5329.0
SKIC3	-5312.0
MTO1	-5305.0
PSMB5	-5303.0
UBB	-5278.0
SNIP1	-5267.0
HNRNPH1	-5243.0
PES1	-5232.0
TRDMT1	-5194.0
CWC15	-5137.0
RPL30	-5126.0
RNMT	-5078.0
TUT7	-5064.0
PSMA3	-5040.0
NOP58	-5004.0
TRMT6	-4986.0
NAT10	-4972.0
WTAP	-4963.0
PPIL2	-4856.0
RPL22L1	-4844.0
POLR2H	-4815.0
GTF2H5	-4812.0
PRPF40A	-4806.0
HSPA1A	-4799.0
POLDIP3	-4797.0
DNAJC8	-4796.0
NUP160	-4777.0
RBM42	-4765.0
ZNF473	-4764.0
NOL12	-4751.0
CNOT10	-4711.0
DDX52	-4689.0
LSM1	-4687.0
DHX16	-4672.0
RPS28	-4667.0
CNOT6L	-4649.0
METTL3	-4646.0
SENP3	-4622.0
RPL18	-4599.0
MAGOH	-4562.0
LSM3	-4557.0
UTP14C	-4525.0
RPL37A	-4494.0
PCBP1	-4477.0
SNRNP40	-4438.0
MNAT1	-4434.0
RPS6	-4391.0
POP1	-4369.0
RPSA	-4359.0
PLRG1	-4345.0
PPP2R1A	-4275.0
IGF2BP3	-4207.0
NUP93	-4202.0
XRN2	-4193.0
RANBP2	-4186.0
SUGP1	-4163.0
TNPO1	-4140.0
NUP37	-4123.0
SRSF2	-4120.0
SEC13	-4109.0
BUD23	-4108.0
RPL27	-4094.0
PRPF3	-4076.0
RPP21	-4069.0
POM121	-4065.0
POLR2L	-4064.0
CCAR1	-4046.0
GTF2F2	-4002.0
HBS1L	-3999.0
SRSF4	-3993.0
PRPF38A	-3960.0
NSRP1	-3954.0
NUP98	-3940.0
LSM8	-3913.0
EXOSC8	-3911.0
HNRNPL	-3870.0
DDX6	-3849.0
RPLP2	-3834.0
NUP88	-3822.0
LENG1	-3814.0
SRSF3	-3801.0
DCPS	-3787.0
METTL1	-3785.0
CWC25	-3781.0
RPL13A	-3764.5
THG1L	-3698.0
RTRAF	-3697.0
EXOSC7	-3684.0
SARNP	-3648.0
MFAP1	-3628.0
RPS15A	-3600.0
THOC5	-3569.0
U2SURP	-3567.0
CWC22	-3555.0
SNRPD2	-3471.0
TYW3	-3469.0
HNRNPF	-3435.0
RPL12	-3302.0
NUP54	-3291.0
RNGTT	-3274.0
PRCC	-3261.0
NOL6	-3256.0
RPL41	-3199.0
PSMB7	-3196.0
PTBP1	-3191.0
RPP38	-3151.0
PUF60	-3085.0
PPP2R2A	-3068.0
MAPK14	-3056.0
PSMA1	-3041.0
LSM2	-2990.0
POLR2I	-2974.0
RRP1	-2867.0
SNRPC	-2866.0
RPL22	-2808.0
NOB1	-2803.0
RPS15	-2797.0
RBM25	-2738.0
RPL27A	-2722.0
SF3B4	-2719.0
TPR	-2693.0
PPIL4	-2679.0
FUS	-2664.0
TSEN34	-2625.0
NUP205	-2604.0
PSMC5	-2598.0
DDX20	-2580.0
TRMT10C	-2568.0
SNRPN	-2560.0
PSMD7	-2547.0
SF3A2	-2469.0
GEMIN4	-2447.0
IMP3	-2426.0
SNRPA1	-2397.0
C2orf49	-2380.0
CNOT4	-2357.0
RPL5	-2353.0
CNOT7	-2342.0
CDC40	-2333.0
SRSF11	-2320.0
HNRNPA1	-2312.0
YWHAZ	-2100.0
UBC	-2067.0
DHX8	-2058.0
NUP214	-2055.0
RPL35A	-2036.0
NCBP2	-1986.0
CHERP	-1866.0
POM121C	-1851.0
RBM7	-1842.0
CNOT8	-1830.0
RPL7	-1829.0
DDX21	-1785.0
DCP1A	-1777.0
RPS7	-1770.0
EXOSC9	-1736.0
SMN1	-1725.5
SMN2	-1725.5
SRSF5	-1688.0
TCERG1	-1625.0
TSEN2	-1615.0
UTP3	-1595.0
RPL38	-1552.0
CSTF2T	-1503.0
PAN3	-1500.0
NXT1	-1479.0
FTSJ3	-1473.0
RPLP1	-1436.0
U2AF1L4	-1363.0
BYSL	-1360.0
CNOT6	-1349.0
PPIH	-1240.0
RBM39	-1189.0
POLR2F	-1161.0
SLBP	-1160.0
CCNH	-1145.0
WDR3	-1108.0
PSMB6	-1085.0
IGF2BP2	-1053.0
TRMT10A	-972.0
PSMA5	-964.0
PSMB4	-949.0
HNRNPA3	-844.0
TFB1M	-830.0
C1D	-785.0
EPRS1	-769.0
TRMT13	-724.0
PSMA2	-698.0
POLR2A	-696.0
NOP10	-668.0
LSM11	-660.0
CWC27	-659.0
XRN1	-658.0
PRPF19	-636.0
CLP1	-624.0
ADAT1	-615.0
CNOT3	-591.0
SRSF7	-534.0
ELAC2	-503.0
HNRNPA2B1	-468.0
PSMD2	-461.0
TNFSF13	-454.0
PSMD6	-450.0
PSMD1	-441.0
GEMIN5	-414.0
WDR33	-392.0
CRNKL1	-342.0
HNRNPD	-337.0
EBNA1BP2	-314.0
MPHOSPH6	-276.0
CNOT11	-218.0
TFIP11	-192.0
GTF2H1	-188.0
THOC6	-137.0
PPIL3	-125.0
RPS18	-119.0
ZBTB8OS	-118.0
PPIL1	-55.0
PSMD11	-47.0
LSM4	-34.0
NSUN4	-17.0
MAPK11	20.0
TXNL4A	93.0
RPS14	100.0
RNPS1	109.0
CTU2	145.0
SRSF1	160.0
TRMT61B	176.0
PRPF18	242.0
SRSF12	258.0
UTP18	296.0
PSME3	308.0
EDC3	341.0
RIOK1	342.0
A1CF	378.0
DCP1B	402.0
ZNF830	409.0
LUC7L3	422.0
RCL1	439.0
SNW1	461.0
SNRNP35	463.0
RPL34	464.0
RPL21	477.0
HSPA8	486.0
CSNK1D	501.0
UPF2	513.0
PRKCA	547.0
ELAVL1	577.0
SNRPB2	600.0
XAB2	633.0
PSMB9	675.0
NSUN2	709.0
UTP15	768.0
UBL5	785.0
RPS21	801.0
TSR3	832.0
ISG20L2	837.0
HNRNPU	845.0
SKIC2	846.0
APOBEC4	858.0
SMG7	897.0
EMG1	941.0
GAR1	953.0
DCAF13	954.0
ZFP36L1	975.0
SRRT	1115.0
PSMD5	1121.0
CNOT9	1230.0
SMG1	1237.0
PRORP	1301.0
TRMT1	1320.0
DHX38	1365.0
AAAS	1385.0
GSPT1	1402.0
EXOSC2	1431.0
EXOSC1	1467.0
SF3B1	1485.0
PSMD12	1518.0
TRMT5	1555.0
RPS11	1577.0
ZMAT5	1663.0
EXOSC10	1697.0
URM1	1708.0
RPL8	1720.0
NUP133	1721.0
SNRPD3	1725.0
FYTTD1	1760.0
PAPOLA	1779.0
PSMD13	1814.0
SAP18	1866.0
NOC4L	1868.0
DDX41	1873.0
NUP155	1883.0
DDX47	1900.0
MRM3	1938.0
PATL1	1980.0
PSMC4	1992.0
HNRNPM	2088.0
NUP58	2106.0
RBM8A	2115.0
GNL3	2176.0
WDR77	2182.0
SNRNP48	2198.0
PPP1R8	2217.0
SRSF8	2224.0
PPIE	2282.0
CLNS1A	2296.0
TUT4	2297.0
RPS5	2306.0
TEX10	2329.0
BMS1	2355.0
NOP14	2368.0
THOC7	2458.0
SRRM1	2471.0
SNRNP27	2497.0
PSMD3	2572.0
PARN	2596.0
CPSF4	2598.0
SF3A1	2601.0
SNRNP25	2609.0
SKIC8	2640.0
SEH1L	2648.0
PNN	2670.0
DHX15	2703.0
PSMB2	2710.0
TNKS1BP1	2711.0
RRP36	2715.0
RPL24	2722.0
POLR2B	2810.0
SMG6	2836.0
UBA52	2905.0
DHX35	2917.0
TSEN54	2963.0
SMG9	2990.0
ADAT3	3012.0
QTRT1	3026.0
RPL32	3032.0
THADA	3037.0
RPL26L1	3044.0
RPLP0	3047.0
NUDT21	3088.0
SDE2	3102.0
CPSF3	3160.0
RPL9	3195.0
SLU7	3203.0
RPS19	3242.0
METTL14	3263.0
CDC5L	3279.0
RPL31	3289.0
LSM5	3312.0
TPRKB	3319.0
APOBEC3H	3369.0
EIF4A3	3370.0
CACTIN	3390.0
SYMPK	3397.0
GCFC2	3410.0
DIMT1	3450.0
SMG8	3482.0
PSMC1	3545.0
UTP11	3583.0
RNPC3	3606.0
SNRNP70	3607.0
RPS3A	3651.0
PRPF6	3664.0
RAE1	3695.0
TBL3	3797.0
PSME4	3824.0
RBM17	3883.0
PUS1	3911.0
TRMT9B	3921.0
PELP1	3965.0
PABPN1	4016.0
HNRNPC	4092.0
GLE1	4117.0
POLR2J	4123.0
PPWD1	4173.0
RAN	4175.0
PAIP1	4181.0
RPL10L	4242.0
EIF4E	4273.0
BOP1	4274.0
SMG5	4317.0
SF3B3	4320.0
MTERF4	4364.0
NUP188	4396.0
NUP42	4406.0
RPS29	4414.0
CTU1	4433.0
NCBP1	4442.0
GPATCH1	4481.0
PSME2	4493.0
CSTF1	4494.0
RPS27	4496.0
RPL28	4510.0
WBP11	4532.0
POLR2C	4579.0
DUS2	4608.0
GTF2H4	4615.0
SUPT5H	4635.0
RPS3	4667.0
TGS1	4689.0
USP39	4706.0
RBM5	4712.0
PDCD11	4764.0
PRPF4	4785.0
DHX37	4835.0
TSR1	4842.0
TYW5	4875.0
PSMA8	4885.0
PRPF8	4910.0
RPS13	4948.0
YBX1	4979.0
WDR46	4992.0
SNRPF	5009.0
SRRM2	5057.0
TRMU	5100.0
RPL7A	5102.0
RPS25	5161.0
TRMT61A	5164.0
ZFP36	5188.0
EXOSC3	5199.0
XPOT	5213.0
GTF2H3	5292.0
LCMT2	5318.0
PUS7	5368.0
SF3A3	5455.0
MAPKAPK2	5464.0
ETF1	5469.0
DHX9	5500.0
DDX1	5558.0
AKT1	5667.0
CTNNBL1	5715.0
POP4	5724.0
DCP2	5768.0
RIOK3	5860.0
RPL18A	5878.0
EXOSC4	5890.0
PCBP2	5938.0
PRKCD	5948.0
RPS2	6067.0
NUP43	6107.0
PRKRIP1	6134.0
RPL36AL	6285.5
RPP14	6298.0
PSME1	6314.0
LSM7	6322.0
DDX42	6325.0
APOBEC3B	6523.0
POLR2E	6530.0
UPF3A	6647.0
RPL19	6671.0
PPP2CA	6732.0
DDX39A	6778.0
RPL14	6785.0
KHSRP	6934.0
POLR2D	6966.0
FAU	6980.0
RPL23A	7062.0
NXF1	7106.0
HSPB1	7147.0
RPL15	7171.0
PCF11	7189.0
APOBEC3A	7240.0
ALKBH8	7408.0
SNRPE	7418.0
NOP2	7475.0
ADARB1	7518.0
NCL	7569.0
ERCC2	7598.0
NHP2	7635.0
ADAR	7637.0
DDX39B	7649.0
LSM10	7678.0
NOL9	7689.0
EDC4	7717.0
U2AF2	7762.0
RPS8	7774.0
SNRNP200	7779.0
NUP210	7811.0
EXOSC6	7840.0
CCDC12	7886.0
NUP62	7909.0
RPL3L	8039.0
TP53RK	8056.0
SET	8189.0
PHAX	8204.0
RBM22	8205.0
UPF1	8257.0
TRMT44	8392.0
RPL29	8421.0
NT5C3B	8443.0
RBM28	8508.0
SF1	8538.0
EIF4G1	8539.0
MRM1	8541.0
SF3B6	8877.0
POP5	8972.0
RPL10A	9024.0
RPL35	9213.0
ZMAT2	9362.0
SEM1	9392.0
CPSF1	9453.0
RPS24	9490.0
RRP7A	9666.0
RPL36	9849.0
PWP2	9913.0

---

REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE

REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE

	1025
set	REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE
setSize	66
pANOVA	0.000465
s.dist	-0.249
p.adjustANOVA	0.0166

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H2AC18	-10402.5
H2AC19	-10402.5
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
H2BC9	-9375.5
H2AC4	-9326.0
MIS18A	-9146.0
NPM1	-9022.0
CENPW	-8754.0
H2BC15	-8620.0
H2AX	-8295.0
HJURP	-8086.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H2AC18	-10402.5
H2AC19	-10402.5
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
RUVBL1	-9655.0
H2BC8	-9584.0
H2BC17	-9503.0
H2BC9	-9375.5
H2AC4	-9326.0
MIS18A	-9146.0
NPM1	-9022.0
CENPW	-8754.0
H2BC15	-8620.0
H2AX	-8295.0
HJURP	-8086.0
H4C13	-7923.0
CENPA	-7025.0
KNL1	-6549.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
H2AZ2	-5775.0
H2BC11	-5756.0
SMARCA5	-5263.0
CENPP	-4981.0
CENPL	-3607.0
RBBP4	-3061.0
H4C4	-2969.0
RSF1	-2759.0
H4C11	-2506.0
CENPQ	-2491.0
H2BC4	-2161.0
H2AC6	-2051.0
CENPC	-1901.0
OIP5	-1613.0
H4C5	-1423.0
H2BC5	-999.0
H2BC12	-482.0
ITGB3BP	-255.0
H4C3	423.0
CENPU	759.0
CENPN	1116.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
CENPT	2001.0
CENPO	2415.0
H2BC21	2421.0
H2AZ1	2761.0
CENPH	3473.0
MIS18BP1	3889.0
H4C2	4419.0
H2AC20	5150.0
CENPK	5388.0
H2BC14	6016.0
H2BC1	6290.0
H4C6	6913.0
CENPM	7288.0
CENPS	8690.0
H2AC14	9915.0

---

REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

	851
set	REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION
setSize	98
pANOVA	0.000497
s.dist	-0.204
p.adjustANOVA	0.0174

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
TAF1D	-9084.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
POLR1E	-7855.0
POLR1B	-7397.0
MBD3	-6559.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
CBX3	-5783.0
H2AZ2	-5775.0
H2BC11	-5756.0
SMARCA5	-5263.0
H3C2	-4876.0
KAT2B	-4853.0
POLR2H	-4815.0
POLR1G	-4538.0
POLR1D	-4307.0
POLR2L	-4064.0
GSK3B	-4058.0
POLR1C	-3745.0
HDAC1	-3246.0
ACTB	-3090.0
RBBP4	-3061.0
H4C4	-2969.0
DEK	-2635.0
H4C11	-2506.0
H2BC4	-2161.0
EHMT2	-2146.0
H2AC6	-2051.0
BAZ1B	-1820.0
DDX21	-1785.0
ERCC6	-1695.0
EP300	-1428.0
H4C5	-1423.0
H3-3A	-1342.0
POLR1H	-1267.0
POLR2F	-1161.0
MYBBP1A	-1095.0
H2BC5	-999.0
H2BC12	-482.0
MYO1C	-267.0
H4C3	423.0
TAF1A	554.0
TBP	561.0
H4C16	1337.0
SF3B1	1485.0
H2AJ	1704.0
H2BC3	1965.0
TAF1C	2010.0
H2BC21	2421.0
POLR1F	2760.0
H2AZ1	2761.0
MTA1	3060.0
TTF1	3503.0
CHD4	3616.0
TAF1B	3685.0
GATAD2B	3897.0
H4C2	4419.0
POLR1A	4622.0
H3C3	4893.0
MTA3	4897.0
H2AC20	5150.0
H2BC14	6016.0
HDAC2	6155.0
GATAD2A	6214.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
CHD3	8284.0
MTA2	8453.0
KAT2A	8790.0
H2AC14	9915.0

---

REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

	437
set	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION
setSize	138
pANOVA	0.000547
s.dist	-0.17
p.adjustANOVA	0.0187

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
UHRF1	-9253.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
POLR2K	-10397.0
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
UHRF1	-9253.0
TAF1D	-9084.0
H3C11	-9013.0
SAP30	-9007.0
MBD2	-8673.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
SAP30BP	-7965.0
H4C13	-7923.0
H3C6	-7918.0
POLR1E	-7855.0
ERCC3	-7795.0
TDG	-7678.0
POLR1B	-7397.0
EZH2	-6787.0
MBD3	-6559.0
CDK7	-6225.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
DNMT1	-5876.0
CBX3	-5783.0
H2AZ2	-5775.0
H2BC11	-5756.0
SUDS3	-5467.0
SMARCA5	-5263.0
H3C2	-4876.0
KAT2B	-4853.0
POLR2H	-4815.0
GTF2H5	-4812.0
TET3	-4724.0
POLR1G	-4538.0
MNAT1	-4434.0
SIN3B	-4370.0
POLR1D	-4307.0
ARID4B	-4090.0
POLR2L	-4064.0
GSK3B	-4058.0
POLR1C	-3745.0
DNMT3A	-3540.0
TET2	-3338.0
HDAC1	-3246.0
ACTB	-3090.0
JARID2	-3082.0
RBBP4	-3061.0
H4C4	-2969.0
MTF2	-2900.0
DEK	-2635.0
H4C11	-2506.0
H2BC4	-2161.0
RRP8	-2160.0
EHMT2	-2146.0
H2AC6	-2051.0
BAZ1B	-1820.0
DDX21	-1785.0
ERCC6	-1695.0
EP300	-1428.0
H4C5	-1423.0
H3-3A	-1342.0
SIN3A	-1299.0
POLR1H	-1267.0
POLR2F	-1161.0
CCNH	-1145.0
MYBBP1A	-1095.0
H2BC5	-999.0
PHF19	-867.0
EED	-862.0
H2BC12	-482.0
MYO1C	-267.0
GTF2H1	-188.0
SUZ12	106.0
H4C3	423.0
TAF1A	554.0
TBP	561.0
SIRT1	613.0
H4C16	1337.0
SF3B1	1485.0
H2AJ	1704.0
SAP18	1866.0
H2BC3	1965.0
PHF1	1976.0
TAF1C	2010.0
AEBP2	2137.0
H2BC21	2421.0
POLR1F	2760.0
H2AZ1	2761.0
MTA1	3060.0
TET1	3421.0
TTF1	3503.0
CHD4	3616.0
TAF1B	3685.0
GATAD2B	3897.0
DNMT3B	3986.0
SAP130	4097.0
H4C2	4419.0
GTF2H4	4615.0
POLR1A	4622.0
H3C3	4893.0
MTA3	4897.0
H2AC20	5150.0
BAZ2A	5271.0
GTF2H3	5292.0
SAP30L	5623.0
H2BC14	6016.0
HDAC2	6155.0
GATAD2A	6214.0
H2BC1	6290.0
H3C1	6458.0
POLR2E	6530.0
H4C6	6913.0
ERCC2	7598.0
UBTF	7947.0
CHD3	8284.0
MTA2	8453.0
KAT2A	8790.0
DNMT3L	9357.0
H2AC14	9915.0

---

REACTOME_MITOTIC_PROMETAPHASE

REACTOME_MITOTIC_PROMETAPHASE

	1094
set	REACTOME_MITOTIC_PROMETAPHASE
setSize	194
pANOVA	0.000644
s.dist	-0.142
p.adjustANOVA	0.0216

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBAL3	-10372
TUBB2A	-10278
ZWINT	-10230
NUP85	-10122
DYNLL1	-10008
ODF2	-9954
CENPE	-9941
CCP110	-9836
SPC24	-9653
NEK9	-9647
SMC4	-9624
NCAPH	-9566
XPO1	-9161
HAUS5	-9053
CEP76	-9017
MIS12	-8977
DYNLL2	-8918
BIRC5	-8888
WAPL	-8778
PRKACA	-8712

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBAL3	-10372
TUBB2A	-10278
ZWINT	-10230
NUP85	-10122
DYNLL1	-10008
ODF2	-9954
CENPE	-9941
CCP110	-9836
SPC24	-9653
NEK9	-9647
SMC4	-9624
NCAPH	-9566
XPO1	-9161
HAUS5	-9053
CEP76	-9017
MIS12	-8977
DYNLL2	-8918
BIRC5	-8888
WAPL	-8778
PRKACA	-8712
TUBGCP4	-8249
PLK4	-8111
HAUS6	-8080
CDK5RAP2	-7957
CSNK1E	-7784
DCTN2	-7732
CSNK2A2	-7701
SPC25	-7594
NINL	-7514
BUB1	-7509
SKA1	-7499
TUBB	-7392
CEP63	-7295
KIF2B	-7174
CEP152	-7092
DCTN3	-7069
CENPA	-7025
CENPF	-6868
NEDD1	-6757
HSP90AA1	-6752
SGO2	-6645
KNL1	-6549
CNTRL	-6497
MZT2B	-6428
MAD2L1	-6363
PPP2R1B	-6311
PPP2R5B	-6192
PPP2R5D	-5981
NCAPD2	-5867
NUP107	-5851
CENPJ	-5832
SMC2	-5782
TUBB8	-5716
PCNT	-5487
NDC80	-5484
DYNC1LI1	-5413
CSNK2B	-5291
SGO1	-5198
NUDC	-5184
MZT2A	-5166
HAUS4	-5164
CCNB1	-5146
CENPP	-4981
KIF2A	-4900
TUBG1	-4811
TUBB4A	-4807
NUP160	-4777
SMC3	-4651
CLASP2	-4463
EML4	-4389
PDS5B	-4294
PPP2R1A	-4275
MAD1L1	-4226
RANBP2	-4186
KIF2C	-4164
NUP37	-4123
SEC13	-4109
PCM1	-4085
MAPRE1	-4007
NUP98	-3940
SPDL1	-3860
HAUS3	-3760
ZWILCH	-3655
CENPL	-3607
TUBGCP2	-3575
AKAP9	-3477
HAUS1	-3468
CEP43	-3422
SKA2	-3415
TUBGCP5	-3405
INCENP	-3300
DYNC1I1	-3186
CEP164	-3164
TUBA1B	-2907
CEP70	-2853
TUBA1C	-2799
NEK7	-2533
CENPQ	-2491
KIF18A	-2373
CEP72	-2259
TUBA8	-2181
NDEL1	-2044
TUBA3C	-2009
DYNC1LI2	-1905
CENPC	-1901
CSNK2A1	-1846
PPP2R5C	-1840
STAG1	-1424
PAFAH1B1	-1210
RANGAP1	-1144
B9D2	-1005
PRKAR2B	-934
CCNB2	-898
YWHAG	-766
NME7	-669
KNTC1	-667
DSN1	-642
TUBA3E	-637
PPP2R5E	-634
ACTR1A	-611
TUBB2B	-608
ITGB3BP	-255
NCAPG	-250
CEP78	-180
ALMS1	-87
CLASP1	104
CDC20	243
DCTN1	261
SDCCAG8	367
CSNK1D	501
CEP41	582
CDK1	604
CDCA5	744
CENPU	759
CEP192	764
NEK2	796
PPP2R5A	866
CLIP1	884
CKAP5	1008
CENPN	1116
AHCTF1	1236
HAUS2	1587
TUBGCP3	1594
NUP133	1721
YWHAE	1817
CENPT	2001
CEP290	2164
CENPO	2415
NUF2	2503
NDE1	2582
SEH1L	2648
CEP135	2694
CDCA8	2698
TUBA4B	3110
DYNC1I2	3247
TAOK1	3350
PLK1	3423
CENPH	3473
DYNC1H1	3577
BUB3	3598
TUBB3	3736
RAD21	3920
HAUS8	4192
SFI1	4288
CEP57	4409
ZW10	4480
RPS27	4496
NUMA1	4544
PPP2CB	4668
TUBG2	4879
SSNA1	5028
AURKB	5224
CENPK	5388
NSL1	5459
TUBA4A	5567
PDS5A	5596
CEP250	5926
TUBA1A	6100
NUP43	6107
PPP1CC	6592
PPP2CA	6732
CEP131	6826
TUBB4B	6910
MZT1	6960
TUBB6	7030
RCC2	7254
CENPM	7288
BUB1B	7699
TUBB1	7729
NEK6	8099
PMF1	8129
TUBGCP6	8154
CENPS	8690
TUBA3D	8852

---

REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION

REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION

	738
set	REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION
setSize	68
pANOVA	0.000816
s.dist	-0.235
p.adjustANOVA	0.0268

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2BC13	-10817.0
H2BC10	-10719.0
H2AC7	-10629.5
H2BC7	-10629.5
H3C12	-10612.0
H3C8	-10552.0
H2AC18	-10402.5
H2AC19	-10402.5
H3C4	-10062.0
H4C9	-9887.0
H4C12	-9845.0
H2AC8	-9679.0
H2BC8	-9584.0
H2BC17	-9503.0
H3C10	-9467.0
H2BC9	-9375.5
H3C7	-9375.5
H2AC4	-9326.0
H3C11	-9013.0
H2BC15	-8620.0
H2AX	-8295.0
H3-3B	-8282.0
H4C13	-7923.0
H3C6	-7918.0
MBD3	-6559.0
H4C8	-5994.0
H2BC26	-5963.0
H2BC6	-5953.0
H4C1	-5951.0
CBX3	-5783.0
H2AZ2	-5775.0
H2BC11	-5756.0
H3C2	-4876.0
HDAC1	-3246.0
RBBP4	-3061.0
H4C4	-2969.0
H4C11	-2506.0
H2BC4	-2161.0
EHMT2	-2146.0
H2AC6	-2051.0
ERCC6	-1695.0
H4C5	-1423.0
H3-3A	-1342.0
H2BC5	-999.0
H2BC12	-482.0
H4C3	423.0
H4C16	1337.0
H2AJ	1704.0
H2BC3	1965.0
H2BC21	2421.0
H2AZ1	2761.0
MTA1	3060.0
TTF1	3503.0
CHD4	3616.0
GATAD2B	3897.0
H4C2	4419.0
H3C3	4893.0
MTA3	4897.0
H2AC20	5150.0
H2BC14	6016.0
HDAC2	6155.0
GATAD2A	6214.0
H2BC1	6290.0
H3C1	6458.0
H4C6	6913.0
CHD3	8284.0
MTA2	8453.0
H2AC14	9915.0

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.2.0                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gtools_3.9.5                                       
##  [6] tibble_3.2.1                                       
##  [7] dplyr_1.1.4                                        
##  [8] echarts4r_0.4.5                                    
##  [9] png_0.1-8                                          
## [10] gridExtra_2.3                                      
## [11] missMethyl_1.36.0                                  
## [12] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [13] beeswarm_0.4.0                                     
## [14] kableExtra_1.3.4                                   
## [15] gplots_3.1.3                                       
## [16] mitch_1.15.0                                       
## [17] tictoc_1.2                                         
## [18] HGNChelper_0.8.1                                   
## [19] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [20] IlluminaHumanMethylation450kmanifest_0.4.0         
## [21] minfi_1.48.0                                       
## [22] bumphunter_1.44.0                                  
## [23] locfit_1.5-9.8                                     
## [24] iterators_1.0.14                                   
## [25] foreach_1.5.2                                      
## [26] Biostrings_2.70.1                                  
## [27] XVector_0.42.0                                     
## [28] SummarizedExperiment_1.32.0                        
## [29] Biobase_2.62.0                                     
## [30] MatrixGenerics_1.14.0                              
## [31] matrixStats_1.2.0                                  
## [32] GenomicRanges_1.54.1                               
## [33] GenomeInfoDb_1.38.2                                
## [34] IRanges_2.36.0                                     
## [35] S4Vectors_0.40.2                                   
## [36] BiocGenerics_0.48.1                                
## [37] eulerr_7.0.0                                       
## [38] limma_3.58.1                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.2              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.3            preprocessCore_1.64.0    
##   [7] XML_3.99-0.16             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.8               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.8                httpuv_1.6.13            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.3             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.6                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] webshot_0.5.5             illuminaio_0.44.0        
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.8           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.3           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] SparseArray_1.2.2         xfun_0.41                
##  [55] HDF5Array_1.30.0          withr_2.5.2              
##  [57] fastmap_1.1.1             rhdf5filters_1.14.1      
##  [59] fansi_1.0.6               openssl_2.1.1            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.58.0           
##  [67] RSQLite_2.3.4             utf8_1.2.4               
##  [69] tidyr_1.3.0               generics_0.1.3           
##  [71] data.table_1.14.10        rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.4         S4Arrays_1.2.0           
##  [77] ggstats_0.5.1             pkgconfig_2.0.3          
##  [79] gtable_0.3.4              blob_1.2.4               
##  [81] siggenes_1.76.0           htmltools_0.5.7          
##  [83] scales_1.3.0              rstudioapi_0.15.0        
##  [85] knitr_1.45                tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-163             
##  [89] curl_5.2.0                org.Hs.eg.db_3.18.0      
##  [91] cachem_1.0.8              rhdf5_2.46.1             
##  [93] stringr_1.5.1             KernSmooth_2.23-22       
##  [95] AnnotationDbi_1.64.1      restfulr_0.0.15          
##  [97] GEOquery_2.70.0           pillar_1.9.0             
##  [99] grid_4.3.2                reshape_0.8.9            
## [101] vctrs_0.6.5               promises_1.2.1           
## [103] dbplyr_2.4.0              xtable_1.8-4             
## [105] evaluate_0.23             readr_2.1.4              
## [107] GenomicFeatures_1.54.1    cli_3.6.2                
## [109] compiler_4.3.2            Rsamtools_2.18.0         
## [111] rlang_1.1.2               crayon_1.5.2             
## [113] rngtools_1.5.2            nor1mix_1.3-2            
## [115] mclust_6.0.1              plyr_1.8.9               
## [117] stringi_1.8.3             viridisLite_0.4.2        
## [119] BiocParallel_1.36.0       munsell_0.5.0            
## [121] Matrix_1.6-1.1            hms_1.1.3                
## [123] sparseMatrixStats_1.14.0  bit64_4.0.5              
## [125] Rhdf5lib_1.24.1           KEGGREST_1.42.0          
## [127] statmod_1.5.0             shiny_1.8.0              
## [129] highr_0.10                memoise_2.0.1            
## [131] bslib_0.6.1               bit_4.0.5

END of report