Mitch Report

date generated: 2024-01-18

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
A1BG	-0.0067997
A1BG-AS1	-0.0099339
A1CF	0.0013692
A2M	-0.0010046
A2M-AS1	-0.0086328
A2ML1	0.0048024

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	1654
num_genes_in_profile	22007
duplicated_genes_present	0
num_profile_genes_in_sets	10383
num_profile_genes_not_in_sets	11624

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: c2.cp.reactome.v2023.1.Hs.symbols.gmt

Gene set metrics

	Gene sets metrics
num_genesets	1654
num_genesets_excluded	365
num_genesets_included	1289

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
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set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME METABOLISM OF RNA	675	5.95e-19	0.2010	9.78e-16
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	263	2.82e-12	0.2500	2.32e-09
REACTOME KERATINIZATION	210	1.51e-11	-0.2700	8.29e-09
REACTOME CELL CYCLE	666	1.61e-10	0.1450	6.63e-08
REACTOME OLFACTORY SIGNALING PATHWAY	348	4.18e-10	-0.1950	1.37e-07
REACTOME MRNA SPLICING	197	3.66e-09	0.2440	1.00e-06
REACTOME RNA POLYMERASE II TRANSCRIPTION	1336	8.63e-09	0.0938	2.02e-06
REACTOME CELL CYCLE MITOTIC	539	1.71e-08	0.1420	3.51e-06
REACTOME TRANSCRIPTIONAL REGULATION BY TP53	351	5.06e-08	0.1690	9.24e-06
REACTOME CELLULAR RESPONSES TO STIMULI	779	7.00e-08	0.1140	1.15e-05
REACTOME ADAPTIVE IMMUNE SYSTEM	729	2.50e-07	0.1120	3.45e-05
REACTOME INFECTIOUS DISEASE	910	2.52e-07	0.1010	3.45e-05
REACTOME TRANSLATION	278	2.83e-07	0.1790	3.57e-05
REACTOME FORMATION OF THE CORNIFIED ENVELOPE	125	3.38e-07	-0.2640	3.96e-05
REACTOME CHROMATIN MODIFYING ENZYMES	252	5.82e-07	0.1830	6.37e-05
REACTOME SENSORY PERCEPTION	555	7.94e-07	-0.1230	8.15e-05
REACTOME M PHASE	398	1.18e-06	0.1420	1.14e-04
REACTOME CELL CYCLE CHECKPOINTS	284	3.59e-06	0.1600	3.27e-04
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	1356	9.35e-06	0.0717	8.08e-04
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	361	1.75e-05	0.1320	1.43e-03
REACTOME HIV INFECTION	223	1.90e-05	0.1660	1.48e-03
REACTOME TCR SIGNALING	113	2.39e-05	0.2300	1.78e-03
REACTOME UNFOLDED PROTEIN RESPONSE UPR	88	3.01e-05	0.2570	2.07e-03
REACTOME MITOTIC PROMETAPHASE	194	3.02e-05	0.1740	2.07e-03
REACTOME SUMOYLATION	179	3.75e-05	0.1790	2.46e-03
REACTOME PTEN REGULATION	135	5.59e-05	0.2010	3.53e-03
REACTOME MITOTIC METAPHASE AND ANAPHASE	228	6.39e-05	0.1540	3.89e-03
REACTOME HOST INTERACTIONS OF HIV FACTORS	127	7.45e-05	0.2040	4.36e-03
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	296	7.70e-05	0.1340	4.36e-03
REACTOME SARS COV INFECTIONS	392	9.22e-05	0.1150	5.04e-03
REACTOME SNRNP ASSEMBLY	53	1.23e-04	0.3050	6.47e-03
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	418	1.26e-04	0.1090	6.47e-03
REACTOME RRNA PROCESSING	192	1.37e-04	0.1600	6.80e-03
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	78	1.74e-04	0.2460	8.39e-03
REACTOME S PHASE	159	2.03e-04	0.1710	9.53e-03
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	86	2.11e-04	0.2310	9.62e-03
REACTOME REGULATION OF TP53 ACTIVITY	156	2.36e-04	0.1710	1.05e-02
REACTOME SUMOYLATION OF DNA REPLICATION PROTEINS	46	2.59e-04	0.3110	1.12e-02
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	291	3.77e-04	-0.1210	1.59e-02
REACTOME SARS COV 2 HOST INTERACTIONS	191	4.15e-04	0.1480	1.71e-02
REACTOME SEPARATION OF SISTER CHROMATIDS	184	4.45e-04	0.1500	1.78e-02
REACTOME UB SPECIFIC PROCESSING PROTEASES	187	4.90e-04	0.1480	1.90e-02
REACTOME DNA REPAIR	321	4.98e-04	0.1130	1.90e-02
REACTOME NEDDYLATION	235	5.65e-04	0.1310	2.11e-02
REACTOME SARS COV 2 INFECTION	281	6.14e-04	0.1190	2.23e-02
REACTOME PROTEIN LOCALIZATION	153	6.26e-04	0.1600	2.23e-02
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION	59	7.30e-04	0.2540	2.55e-02
REACTOME G2 M CHECKPOINTS	162	8.15e-04	0.1520	2.79e-02
REACTOME COSTIMULATION BY THE CD28 FAMILY	64	8.73e-04	0.2410	2.92e-02
REACTOME O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	38	8.97e-04	-0.3110	2.94e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
REACTOME METABOLISM OF RNA	675	5.95e-19	0.201000	9.78e-16
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	263	2.82e-12	0.250000	2.32e-09
REACTOME KERATINIZATION	210	1.51e-11	-0.270000	8.29e-09
REACTOME CELL CYCLE	666	1.61e-10	0.145000	6.63e-08
REACTOME OLFACTORY SIGNALING PATHWAY	348	4.18e-10	-0.195000	1.37e-07
REACTOME MRNA SPLICING	197	3.66e-09	0.244000	1.00e-06
REACTOME RNA POLYMERASE II TRANSCRIPTION	1336	8.63e-09	0.093800	2.02e-06
REACTOME CELL CYCLE MITOTIC	539	1.71e-08	0.142000	3.51e-06
REACTOME TRANSCRIPTIONAL REGULATION BY TP53	351	5.06e-08	0.169000	9.24e-06
REACTOME CELLULAR RESPONSES TO STIMULI	779	7.00e-08	0.114000	1.15e-05
REACTOME ADAPTIVE IMMUNE SYSTEM	729	2.50e-07	0.112000	3.45e-05
REACTOME INFECTIOUS DISEASE	910	2.52e-07	0.101000	3.45e-05
REACTOME TRANSLATION	278	2.83e-07	0.179000	3.57e-05
REACTOME FORMATION OF THE CORNIFIED ENVELOPE	125	3.38e-07	-0.264000	3.96e-05
REACTOME CHROMATIN MODIFYING ENZYMES	252	5.82e-07	0.183000	6.37e-05
REACTOME SENSORY PERCEPTION	555	7.94e-07	-0.123000	8.15e-05
REACTOME M PHASE	398	1.18e-06	0.142000	1.14e-04
REACTOME CELL CYCLE CHECKPOINTS	284	3.59e-06	0.160000	3.27e-04
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	1356	9.35e-06	0.071700	8.08e-04
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	361	1.75e-05	0.132000	1.43e-03
REACTOME HIV INFECTION	223	1.90e-05	0.166000	1.48e-03
REACTOME TCR SIGNALING	113	2.39e-05	0.230000	1.78e-03
REACTOME UNFOLDED PROTEIN RESPONSE UPR	88	3.01e-05	0.257000	2.07e-03
REACTOME MITOTIC PROMETAPHASE	194	3.02e-05	0.174000	2.07e-03
REACTOME SUMOYLATION	179	3.75e-05	0.179000	2.46e-03
REACTOME PTEN REGULATION	135	5.59e-05	0.201000	3.53e-03
REACTOME MITOTIC METAPHASE AND ANAPHASE	228	6.39e-05	0.154000	3.89e-03
REACTOME HOST INTERACTIONS OF HIV FACTORS	127	7.45e-05	0.204000	4.36e-03
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	296	7.70e-05	0.134000	4.36e-03
REACTOME SARS COV INFECTIONS	392	9.22e-05	0.115000	5.04e-03
REACTOME SNRNP ASSEMBLY	53	1.23e-04	0.305000	6.47e-03
REACTOME DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	418	1.26e-04	0.109000	6.47e-03
REACTOME RRNA PROCESSING	192	1.37e-04	0.160000	6.80e-03
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	78	1.74e-04	0.246000	8.39e-03
REACTOME S PHASE	159	2.03e-04	0.171000	9.53e-03
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	86	2.11e-04	0.231000	9.62e-03
REACTOME REGULATION OF TP53 ACTIVITY	156	2.36e-04	0.171000	1.05e-02
REACTOME SUMOYLATION OF DNA REPLICATION PROTEINS	46	2.59e-04	0.311000	1.12e-02
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	291	3.77e-04	-0.121000	1.59e-02
REACTOME SARS COV 2 HOST INTERACTIONS	191	4.15e-04	0.148000	1.71e-02
REACTOME SEPARATION OF SISTER CHROMATIDS	184	4.45e-04	0.150000	1.78e-02
REACTOME UB SPECIFIC PROCESSING PROTEASES	187	4.90e-04	0.148000	1.90e-02
REACTOME DNA REPAIR	321	4.98e-04	0.113000	1.90e-02
REACTOME NEDDYLATION	235	5.65e-04	0.131000	2.11e-02
REACTOME SARS COV 2 INFECTION	281	6.14e-04	0.119000	2.23e-02
REACTOME PROTEIN LOCALIZATION	153	6.26e-04	0.160000	2.23e-02
REACTOME REGULATION OF PTEN GENE TRANSCRIPTION	59	7.30e-04	0.254000	2.55e-02
REACTOME G2 M CHECKPOINTS	162	8.15e-04	0.152000	2.79e-02
REACTOME COSTIMULATION BY THE CD28 FAMILY	64	8.73e-04	0.241000	2.92e-02
REACTOME O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	38	8.97e-04	-0.311000	2.94e-02
REACTOME ORGANELLE BIOGENESIS AND MAINTENANCE	277	9.62e-04	0.115000	3.08e-02
REACTOME TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	9.76e-04	0.244000	3.08e-02
REACTOME MITOTIC G2 G2 M PHASES	194	1.02e-03	0.137000	3.11e-02
REACTOME ECM PROTEOGLYCANS	73	1.04e-03	-0.222000	3.11e-02
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX3	94	1.06e-03	0.195000	3.11e-02
REACTOME DEFENSINS	33	1.06e-03	-0.329000	3.11e-02
REACTOME SIGNALING BY WNT	318	1.10e-03	0.106000	3.17e-02
REACTOME MITOTIC G1 PHASE AND G1 S TRANSITION	145	1.12e-03	0.157000	3.17e-02
REACTOME TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	43	1.15e-03	0.287000	3.17e-02
REACTOME SIGNALING BY ROBO RECEPTORS	206	1.16e-03	0.131000	3.17e-02
REACTOME DEUBIQUITINATION	260	1.22e-03	0.116000	3.29e-02
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	18	1.27e-03	0.439000	3.36e-02
REACTOME SIGNALING BY NOTCH4	80	1.29e-03	0.208000	3.36e-02
REACTOME GENERATION OF SECOND MESSENGER MOLECULES	30	1.31e-03	0.339000	3.37e-02
REACTOME CILIUM ASSEMBLY	190	1.36e-03	0.135000	3.43e-02
REACTOME RNA POLYMERASE II TRANSCRIPTION TERMINATION	62	1.50e-03	0.233000	3.73e-02
REACTOME MITOTIC SPINDLE CHECKPOINT	109	1.57e-03	0.175000	3.79e-02
REACTOME KSRP KHSRP BINDS AND DESTABILIZES MRNA	17	1.57e-03	0.443000	3.79e-02
REACTOME RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	58	1.60e-03	0.240000	3.82e-02
REACTOME PD 1 SIGNALING	21	1.63e-03	0.397000	3.82e-02
REACTOME RESOLUTION OF SISTER CHROMATID COHESION	120	1.76e-03	0.165000	4.08e-02
REACTOME APOPTOSIS	173	1.96e-03	0.136000	4.46e-02
REACTOME RHO GTPASE EFFECTORS	305	1.98e-03	0.103000	4.46e-02
REACTOME MEMBRANE TRAFFICKING	603	2.26e-03	0.072800	4.72e-02
REACTOME METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	16	2.27e-03	-0.441000	4.72e-02
REACTOME ASPIRIN ADME	42	2.27e-03	-0.272000	4.72e-02
REACTOME REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	54	2.29e-03	0.240000	4.72e-02
REACTOME SIGNALING BY NOTCH	234	2.29e-03	0.116000	4.72e-02
REACTOME PROTEIN UBIQUITINATION	76	2.30e-03	0.202000	4.72e-02
REACTOME RHO GTPASES ACTIVATE FORMINS	136	2.30e-03	0.151000	4.72e-02
REACTOME REGULATION OF EXPRESSION OF SLITS AND ROBOS	161	2.38e-03	0.139000	4.82e-02
REACTOME TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	36	2.46e-03	0.292000	4.89e-02
REACTOME SUMOYLATION OF UBIQUITINYLATION PROTEINS	39	2.47e-03	0.280000	4.89e-02
REACTOME TRNA PROCESSING IN THE NUCLEUS	58	2.56e-03	0.229000	4.90e-02
REACTOME DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	2.56e-03	0.191000	4.90e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT	90	2.56e-03	0.184000	4.90e-02
REACTOME DRUG ADME	103	2.62e-03	-0.172000	4.95e-02
REACTOME NS1 MEDIATED EFFECTS ON HOST PATHWAYS	41	2.98e-03	0.268000	5.43e-02
REACTOME MAPK6 MAPK4 SIGNALING	91	3.03e-03	0.180000	5.43e-02
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	111	3.06e-03	0.163000	5.43e-02
REACTOME SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	74	3.06e-03	0.199000	5.43e-02
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	29	3.11e-03	0.317000	5.43e-02
REACTOME DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	61	3.15e-03	0.219000	5.43e-02
REACTOME TRNA PROCESSING	105	3.19e-03	0.167000	5.43e-02
REACTOME PERK REGULATES GENE EXPRESSION	31	3.22e-03	0.306000	5.43e-02
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX	57	3.23e-03	0.226000	5.43e-02
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	20	3.24e-03	0.380000	5.43e-02
REACTOME HIV LIFE CYCLE	145	3.24e-03	0.142000	5.43e-02
REACTOME ADHERENS JUNCTIONS INTERACTIONS	33	3.31e-03	-0.295000	5.49e-02
REACTOME SIGNALING BY BRAF AND RAF1 FUSIONS	63	3.50e-03	0.213000	5.71e-02
REACTOME PROCESSING OF INTRONLESS PRE MRNAS	19	3.52e-03	0.387000	5.71e-02
REACTOME SIGNALING BY NOTCH1	69	3.55e-03	0.203000	5.71e-02
REACTOME SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	54	3.76e-03	0.228000	5.97e-02
REACTOME SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	68	3.82e-03	0.203000	5.97e-02
REACTOME TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	3.82e-03	0.291000	5.97e-02
REACTOME HYALURONAN UPTAKE AND DEGRADATION	12	3.95e-03	0.481000	6.11e-02
REACTOME FCERI MEDIATED NF KB ACTIVATION	78	4.03e-03	0.188000	6.19e-02
REACTOME DEFECTIVE B4GALT1 CAUSES B4GALT1 CDG CDG 2D	8	4.15e-03	-0.585000	6.29e-02
REACTOME SYNTHESIS OF DNA	119	4.21e-03	0.152000	6.29e-02
REACTOME TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	222	4.26e-03	0.111000	6.29e-02
REACTOME SUMOYLATION OF SUMOYLATION PROTEINS	35	4.26e-03	0.279000	6.29e-02
REACTOME BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	42	4.33e-03	-0.254000	6.29e-02
REACTOME E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	58	4.33e-03	0.217000	6.29e-02
REACTOME MAP2K AND MAPK ACTIVATION	38	4.38e-03	0.267000	6.31e-02
REACTOME MITOCHONDRIAL TRANSLATION	93	4.44e-03	0.171000	6.34e-02
REACTOME ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	27	4.62e-03	0.315000	6.54e-02
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	688	4.81e-03	0.063100	6.69e-02
REACTOME ONCOGENIC MAPK SIGNALING	79	4.81e-03	0.183000	6.69e-02
REACTOME ANTIMICROBIAL PEPTIDES	76	5.02e-03	-0.186000	6.93e-02
REACTOME CELLULAR RESPONSE TO CHEMICAL STRESS	188	5.32e-03	0.118000	7.28e-02
REACTOME CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	19	5.47e-03	0.368000	7.33e-02
REACTOME C TYPE LECTIN RECEPTORS CLRS	136	5.51e-03	0.138000	7.33e-02
REACTOME HYALURONAN METABOLISM	17	5.55e-03	0.388000	7.33e-02
REACTOME CELLULAR RESPONSE TO HEAT STRESS	99	5.56e-03	0.161000	7.33e-02
REACTOME INFLUENZA INFECTION	149	5.58e-03	0.132000	7.33e-02
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	19	5.66e-03	0.367000	7.37e-02
REACTOME TOLL LIKE RECEPTOR 9 TLR9 CASCADE	100	5.74e-03	0.160000	7.37e-02
REACTOME SIGNALING BY TGFB FAMILY MEMBERS	119	5.74e-03	0.147000	7.37e-02
REACTOME AUTOPHAGY	144	5.84e-03	0.133000	7.44e-02
REACTOME CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	5.91e-03	0.174000	7.47e-02
REACTOME GASTRULATION	49	6.02e-03	0.227000	7.51e-02
REACTOME MRNA SPLICING MINOR PATHWAY	49	6.05e-03	0.227000	7.51e-02
REACTOME EXTENSION OF TELOMERES	49	6.14e-03	0.226000	7.51e-02
REACTOME DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	39	6.14e-03	0.254000	7.51e-02
REACTOME NEGATIVE REGULATION OF NOTCH4 SIGNALING	53	6.17e-03	0.217000	7.51e-02
REACTOME DNA DOUBLE STRAND BREAK REPAIR	162	6.29e-03	0.124000	7.53e-02
REACTOME INTERFERON SIGNALING	193	6.33e-03	0.114000	7.53e-02
REACTOME SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	679	6.33e-03	0.061400	7.53e-02
REACTOME STABILIZATION OF P53	56	6.44e-03	0.210000	7.58e-02
REACTOME SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	43	6.46e-03	0.240000	7.58e-02
REACTOME NUCLEAR ENVELOPE BREAKDOWN	52	6.68e-03	0.217000	7.78e-02
REACTOME RNA POLYMERASE II TRANSCRIBES SNRNA GENES	77	6.74e-03	0.179000	7.78e-02
REACTOME DNA REPLICATION PRE INITIATION	150	6.79e-03	0.128000	7.78e-02
REACTOME TP53 REGULATES METABOLIC GENES	81	6.82e-03	0.174000	7.78e-02
REACTOME SIGNALING BY NUCLEAR RECEPTORS	283	6.88e-03	0.093400	7.79e-02
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	81	7.09e-03	0.173000	7.97e-02
REACTOME TELOMERE C STRAND SYNTHESIS INITIATION	12	7.23e-03	0.448000	8.05e-02
REACTOME SUMOYLATION OF TRANSCRIPTION FACTORS	20	7.25e-03	0.347000	8.05e-02
REACTOME BETA CATENIN INDEPENDENT WNT SIGNALING	145	8.10e-03	0.127000	8.87e-02
REACTOME REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	81	8.11e-03	0.170000	8.87e-02
REACTOME CHROMOSOME MAINTENANCE	130	8.17e-03	0.134000	8.89e-02
REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	8.27e-03	0.288000	8.94e-02
REACTOME NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	11	8.41e-03	0.459000	9.01e-02
REACTOME NUCLEAR PORE COMPLEX NPC DISASSEMBLY	36	8.49e-03	0.253000	9.01e-02
REACTOME CLEC7A DECTIN 1 SIGNALING	97	8.50e-03	0.155000	9.01e-02
REACTOME EUKARYOTIC TRANSLATION INITIATION	110	8.59e-03	0.145000	9.04e-02
REACTOME IRE1ALPHA ACTIVATES CHAPERONES	48	8.68e-03	0.219000	9.07e-02
REACTOME DNA REPLICATION	178	8.77e-03	0.114000	9.11e-02
REACTOME DEGRADATION OF GLI1 BY THE PROTEASOME	59	9.07e-03	0.196000	9.37e-02
REACTOME KEAP1 NFE2L2 PATHWAY	104	9.20e-03	0.148000	9.44e-02
REACTOME BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	17	9.46e-03	0.364000	9.64e-02
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	20	9.59e-03	0.335000	9.72e-02
REACTOME UCH PROTEINASES	99	9.80e-03	0.150000	9.77e-02
REACTOME ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA	5	9.87e-03	0.666000	9.77e-02
REACTOME INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	37	9.88e-03	0.245000	9.77e-02
REACTOME ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	9.88e-03	0.311000	9.77e-02
REACTOME TRNA AMINOACYLATION	40	1.05e-02	0.234000	1.04e-01
REACTOME NUCLEAR EVENTS MEDIATED BY NFE2L2	77	1.12e-02	0.167000	1.09e-01
REACTOME CELLULAR RESPONSE TO STARVATION	147	1.13e-02	0.121000	1.09e-01
REACTOME PCP CE PATHWAY	91	1.13e-02	0.154000	1.09e-01
REACTOME GERM LAYER FORMATION AT GASTRULATION	17	1.15e-02	0.354000	1.10e-01
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	1.16e-02	0.165000	1.10e-01
REACTOME INTRACELLULAR SIGNALING BY SECOND MESSENGERS	299	1.18e-02	0.084700	1.11e-01
REACTOME EPIGENETIC REGULATION OF GENE EXPRESSION	138	1.18e-02	0.124000	1.11e-01
REACTOME RNA POLYMERASE II PRE TRANSCRIPTION EVENTS	77	1.21e-02	0.165000	1.13e-01
REACTOME STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING	9	1.22e-02	0.482000	1.14e-01
REACTOME NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	22	1.22e-02	0.308000	1.14e-01
REACTOME DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	77	1.25e-02	0.165000	1.15e-01
REACTOME HIV TRANSCRIPTION ELONGATION	42	1.32e-02	0.221000	1.21e-01
REACTOME FC EPSILON RECEPTOR FCERI SIGNALING	127	1.33e-02	0.127000	1.21e-01
REACTOME SIGNALING BY NOTCH2	32	1.34e-02	0.253000	1.22e-01
REACTOME FOXO MEDIATED TRANSCRIPTION	65	1.35e-02	0.177000	1.22e-01
REACTOME BETA DEFENSINS	27	1.36e-02	-0.274000	1.22e-01
REACTOME HATS ACETYLATE HISTONES	129	1.40e-02	0.125000	1.25e-01
REACTOME PROGRAMMED CELL DEATH	204	1.41e-02	0.099700	1.25e-01
REACTOME CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	1.42e-02	0.202000	1.25e-01
REACTOME THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	159	1.44e-02	0.112000	1.26e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	74	1.44e-02	0.164000	1.26e-01
REACTOME MTOR SIGNALLING	40	1.45e-02	0.223000	1.26e-01
REACTOME ALPHA DEFENSINS	6	1.46e-02	-0.576000	1.26e-01
REACTOME MITOCHONDRIAL CALCIUM ION TRANSPORT	23	1.49e-02	0.293000	1.28e-01
REACTOME SUMO IS TRANSFERRED FROM E1 TO E2 UBE2I UBC9	7	1.50e-02	0.531000	1.28e-01
REACTOME G1 S DNA DAMAGE CHECKPOINTS	67	1.51e-02	0.172000	1.28e-01
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	134	1.52e-02	-0.121000	1.28e-01
REACTOME ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	93	1.52e-02	0.146000	1.28e-01
REACTOME INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	198	1.53e-02	0.100000	1.28e-01
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	53	1.63e-02	0.191000	1.36e-01
REACTOME NONSENSE MEDIATED DECAY NMD	107	1.67e-02	0.134000	1.38e-01
REACTOME SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	91	1.67e-02	0.145000	1.38e-01
REACTOME DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15	8	1.68e-02	-0.488000	1.38e-01
REACTOME PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	77	1.70e-02	-0.157000	1.39e-01
REACTOME FORMATION OF THE EARLY ELONGATION COMPLEX	32	1.73e-02	0.243000	1.41e-01
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	73	1.76e-02	0.161000	1.41e-01
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	98	1.76e-02	0.139000	1.41e-01
REACTOME EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	33	1.77e-02	0.239000	1.41e-01
REACTOME TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	17	1.77e-02	0.332000	1.41e-01
REACTOME REGULATION OF RAS BY GAPS	66	1.79e-02	0.169000	1.41e-01
REACTOME SARS COV 2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES	118	1.79e-02	0.126000	1.41e-01
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	9	1.81e-02	0.455000	1.42e-01
REACTOME DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	66	1.81e-02	-0.168000	1.42e-01
REACTOME METABOLISM OF POLYAMINES	56	1.84e-02	0.182000	1.43e-01
REACTOME BLOOD GROUP SYSTEMS BIOSYNTHESIS	21	1.85e-02	-0.297000	1.43e-01
REACTOME PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	1.90e-02	0.311000	1.46e-01
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	106	1.93e-02	0.132000	1.48e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	91	1.96e-02	0.142000	1.48e-01
REACTOME RAB REGULATION OF TRAFFICKING	110	1.96e-02	0.129000	1.48e-01
REACTOME PKMTS METHYLATE HISTONE LYSINES	64	1.96e-02	0.169000	1.48e-01
REACTOME DEFECTIVE CHST6 CAUSES MCDC1	8	1.98e-02	-0.476000	1.48e-01
REACTOME CONDENSATION OF PROMETAPHASE CHROMOSOMES	11	1.98e-02	0.406000	1.48e-01
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	22	1.99e-02	-0.287000	1.48e-01
REACTOME MYD88 INDEPENDENT TLR4 CASCADE	103	2.00e-02	0.133000	1.48e-01
REACTOME TELOMERE MAINTENANCE	106	2.03e-02	0.130000	1.50e-01
REACTOME VIRAL MESSENGER RNA SYNTHESIS	44	2.04e-02	0.202000	1.50e-01
REACTOME HEDGEHOG LIGAND BIOGENESIS	64	2.04e-02	0.168000	1.50e-01
REACTOME VESICLE MEDIATED TRANSPORT	642	2.06e-02	0.053500	1.50e-01
REACTOME TOLL LIKE RECEPTOR CASCADES	158	2.07e-02	0.107000	1.50e-01
REACTOME ORC1 REMOVAL FROM CHROMATIN	70	2.07e-02	0.160000	1.50e-01
REACTOME INTRA GOLGI TRAFFIC	43	2.10e-02	0.203000	1.51e-01
REACTOME REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	84	2.12e-02	0.145000	1.52e-01
REACTOME TRANSLESION SYNTHESIS BY POLH	19	2.13e-02	0.305000	1.52e-01
REACTOME NUCLEAR IMPORT OF REV PROTEIN	34	2.18e-02	0.227000	1.55e-01
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	2.19e-02	0.149000	1.55e-01
REACTOME COMPLEMENT CASCADE	54	2.20e-02	-0.180000	1.55e-01
REACTOME RAB GEFS EXCHANGE GTP FOR GDP ON RABS	81	2.21e-02	0.147000	1.55e-01
REACTOME TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	16	2.23e-02	0.330000	1.56e-01
REACTOME APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	87	2.29e-02	0.141000	1.59e-01
REACTOME AMINO ACIDS REGULATE MTORC1	53	2.32e-02	0.180000	1.61e-01
REACTOME DEGRADATION OF AXIN	54	2.35e-02	0.178000	1.62e-01
REACTOME NEURONAL SYSTEM	388	2.40e-02	-0.066700	1.65e-01
REACTOME PLASMA LIPOPROTEIN CLEARANCE	37	2.40e-02	0.214000	1.65e-01
REACTOME SIGNALING BY PDGF	57	2.48e-02	-0.172000	1.68e-01
REACTOME SCAVENGING OF HEME FROM PLASMA	13	2.48e-02	-0.359000	1.68e-01
REACTOME TRAF6 MEDIATED NF KB ACTIVATION	24	2.55e-02	0.263000	1.72e-01
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	37	2.59e-02	0.212000	1.74e-01
REACTOME PHOSPHOLIPID METABOLISM	201	2.64e-02	0.090800	1.77e-01
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	35	2.64e-02	0.217000	1.77e-01
REACTOME METABOLISM OF STEROID HORMONES	35	2.66e-02	-0.217000	1.77e-01
REACTOME POLB DEPENDENT LONG PATCH BASE EXCISION REPAIR	8	2.67e-02	0.452000	1.77e-01
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	2.71e-02	0.329000	1.79e-01
REACTOME G0 AND EARLY G1	27	2.75e-02	0.245000	1.79e-01
REACTOME RHO GTPASES ACTIVATE WASPS AND WAVES	34	2.75e-02	0.218000	1.79e-01
REACTOME BETA CATENIN PHOSPHORYLATION CASCADE	16	2.75e-02	0.318000	1.79e-01
REACTOME SYNTHESIS OF DIPHTHAMIDE EEF2	8	2.77e-02	0.450000	1.80e-01
REACTOME MITOPHAGY	28	2.80e-02	0.240000	1.80e-01
REACTOME GLUCURONIDATION	23	2.80e-02	-0.265000	1.80e-01
REACTOME NUCLEOTIDE EXCISION REPAIR	107	2.82e-02	0.123000	1.81e-01
REACTOME NCAM1 INTERACTIONS	41	2.84e-02	-0.198000	1.82e-01
REACTOME CELLULAR RESPONSE TO HYPOXIA	74	2.86e-02	0.147000	1.82e-01
REACTOME POLO LIKE KINASE MEDIATED EVENTS	16	2.87e-02	0.316000	1.82e-01
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	32	2.88e-02	0.223000	1.82e-01
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	2.90e-02	0.326000	1.82e-01
REACTOME ETHANOL OXIDATION	12	2.95e-02	-0.363000	1.85e-01
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	30	2.99e-02	0.229000	1.87e-01
REACTOME PROCESSING AND ACTIVATION OF SUMO	10	3.03e-02	0.396000	1.88e-01
REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	20	3.09e-02	0.279000	1.91e-01
REACTOME REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	3.11e-02	0.227000	1.92e-01
REACTOME GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION	7	3.14e-02	-0.470000	1.93e-01
REACTOME BIOLOGICAL OXIDATIONS	210	3.17e-02	-0.086000	1.95e-01
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	14	3.19e-02	0.331000	1.95e-01
REACTOME MTORC1 MEDIATED SIGNALLING	23	3.24e-02	0.258000	1.96e-01
REACTOME G2 M DNA DAMAGE CHECKPOINT	90	3.25e-02	0.130000	1.96e-01
REACTOME ESR MEDIATED SIGNALING	210	3.25e-02	0.085600	1.96e-01
REACTOME FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	17	3.30e-02	0.299000	1.98e-01
REACTOME THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	77	3.30e-02	0.141000	1.98e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	14	3.35e-02	0.328000	2.00e-01
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	54	3.39e-02	0.167000	2.01e-01
REACTOME REGULATED PROTEOLYSIS OF P75NTR	11	3.40e-02	0.369000	2.01e-01
REACTOME BIOSYNTHESIS OF MARESINS	8	3.41e-02	-0.433000	2.01e-01
REACTOME REGULATION OF SIGNALING BY NODAL	9	3.42e-02	0.408000	2.01e-01
REACTOME THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	3.46e-02	0.235000	2.02e-01
REACTOME G2 M DNA REPLICATION CHECKPOINT	5	3.46e-02	0.545000	2.02e-01
REACTOME NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	36	3.47e-02	0.203000	2.02e-01
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	91	3.49e-02	0.128000	2.02e-01
REACTOME TNFR2 NON CANONICAL NF KB PATHWAY	96	3.49e-02	0.125000	2.02e-01
REACTOME INTERLEUKIN 1 FAMILY SIGNALING	146	3.53e-02	0.101000	2.03e-01
REACTOME PEPTIDE HORMONE BIOSYNTHESIS	13	3.58e-02	0.336000	2.05e-01
REACTOME NEGATIVE REGULATION OF MAPK PATHWAY	41	3.60e-02	0.189000	2.05e-01
REACTOME RAP1 SIGNALLING	16	3.60e-02	0.303000	2.05e-01
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	3.64e-02	0.237000	2.07e-01
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	80	3.68e-02	0.135000	2.08e-01
REACTOME INTEGRIN SIGNALING	27	3.69e-02	0.232000	2.08e-01
REACTOME CELL CELL COMMUNICATION	126	3.73e-02	-0.107000	2.10e-01
REACTOME ACTIVATION OF MATRIX METALLOPROTEINASES	30	3.79e-02	-0.219000	2.12e-01
REACTOME DISEASES OF GLYCOSYLATION	137	3.81e-02	-0.103000	2.12e-01
REACTOME POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	27	3.81e-02	0.231000	2.12e-01
REACTOME SUMO IS CONJUGATED TO E1 UBA2 SAE1	5	3.87e-02	0.534000	2.15e-01
REACTOME BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	3.92e-02	0.248000	2.17e-01
REACTOME HEDGEHOG ON STATE	85	3.94e-02	0.129000	2.17e-01
REACTOME POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	3.97e-02	0.238000	2.18e-01
REACTOME AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	4.11e-02	0.161000	2.25e-01
REACTOME MET INTERACTS WITH TNS PROTEINS	5	4.14e-02	-0.527000	2.26e-01
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	16	4.20e-02	0.294000	2.28e-01
REACTOME SUMOYLATION OF RNA BINDING PROTEINS	47	4.21e-02	0.171000	2.28e-01
REACTOME LAGGING STRAND SYNTHESIS	19	4.25e-02	0.269000	2.29e-01
REACTOME AURKA ACTIVATION BY TPX2	69	4.25e-02	0.141000	2.29e-01
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	4.28e-02	0.152000	2.30e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	4.31e-02	0.302000	2.30e-01
REACTOME SYNTHESIS OF 12 EICOSATETRAENOIC ACID DERIVATIVES	7	4.31e-02	0.441000	2.30e-01
REACTOME DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	30	4.33e-02	0.213000	2.30e-01
REACTOME DUAL INCISION IN TC NER	63	4.36e-02	0.147000	2.31e-01
REACTOME DEGRADATION OF DVL	56	4.40e-02	0.156000	2.32e-01
REACTOME FOLDING OF ACTIN BY CCT TRIC	10	4.45e-02	0.367000	2.33e-01
REACTOME SCAVENGING BY CLASS F RECEPTORS	6	4.46e-02	-0.474000	2.33e-01
REACTOME BINDING OF TCF LEF CTNNB1 TO TARGET GENE PROMOTERS	8	4.46e-02	0.410000	2.33e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	49	4.47e-02	0.166000	2.33e-01
REACTOME HIV ELONGATION ARREST AND RECOVERY	33	4.49e-02	0.202000	2.33e-01
REACTOME CELL CELL JUNCTION ORGANIZATION	64	4.53e-02	-0.145000	2.34e-01
REACTOME MITOTIC PROPHASE	134	4.54e-02	0.100000	2.34e-01
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	44	4.54e-02	0.174000	2.34e-01
REACTOME GLYCOLYSIS	70	4.61e-02	0.138000	2.37e-01
REACTOME INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	18	4.65e-02	0.271000	2.38e-01
REACTOME SYNTHESIS OF EPOXY EET AND DIHYDROXYEICOSATRIENOIC ACIDS DHET	8	4.72e-02	-0.405000	2.40e-01
REACTOME SARS COV 1 INFECTION	136	4.73e-02	0.098500	2.41e-01
REACTOME DNA STRAND ELONGATION	31	4.78e-02	0.205000	2.42e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	89	4.78e-02	0.121000	2.42e-01
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	13	4.89e-02	0.315000	2.46e-01
REACTOME UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	19	4.90e-02	-0.261000	2.46e-01
REACTOME RUNX3 REGULATES WNT SIGNALING	8	4.95e-02	0.401000	2.47e-01
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	54	4.95e-02	0.155000	2.47e-01
REACTOME RMTS METHYLATE HISTONE ARGININES	72	5.01e-02	0.133000	2.49e-01
REACTOME GENE SILENCING BY RNA	133	5.05e-02	0.098200	2.50e-01
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	105	5.05e-02	0.110000	2.50e-01
REACTOME SUPPRESSION OF PHAGOSOMAL MATURATION	13	5.14e-02	0.312000	2.53e-01
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	99	5.17e-02	0.113000	2.54e-01
REACTOME INTERFERON ALPHA BETA SIGNALING	70	5.27e-02	0.134000	2.58e-01
REACTOME REGULATION OF TP53 EXPRESSION AND DEGRADATION	37	5.30e-02	0.184000	2.59e-01
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	5.35e-02	0.145000	2.59e-01
REACTOME G PROTEIN BETA GAMMA SIGNALLING	30	5.35e-02	0.204000	2.59e-01
REACTOME ABACAVIR ADME	9	5.35e-02	-0.372000	2.59e-01
REACTOME RHOH GTPASE CYCLE	37	5.35e-02	0.183000	2.59e-01
REACTOME MITOTIC TELOPHASE CYTOKINESIS	11	5.48e-02	0.334000	2.64e-01
REACTOME REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	72	5.53e-02	0.131000	2.65e-01
REACTOME DIGESTION OF DIETARY CARBOHYDRATE	6	5.56e-02	-0.451000	2.66e-01
REACTOME POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	98	5.59e-02	0.112000	2.67e-01
REACTOME BIOSYNTHESIS OF MARESIN LIKE SPMS	6	5.64e-02	-0.450000	2.67e-01
REACTOME NUCLEAR ENVELOPE NE REASSEMBLY	74	5.64e-02	0.128000	2.67e-01
REACTOME NEUREXINS AND NEUROLIGINS	51	5.65e-02	-0.154000	2.67e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION INITIATION	45	5.68e-02	0.164000	2.67e-01
REACTOME DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	60	5.68e-02	0.142000	2.67e-01
REACTOME PINK1 PRKN MEDIATED MITOPHAGY	22	5.70e-02	0.234000	2.67e-01
REACTOME PARASITE INFECTION	57	5.72e-02	0.146000	2.67e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX2	117	5.78e-02	0.102000	2.68e-01
REACTOME DISORDERS OF TRANSMEMBRANE TRANSPORTERS	170	5.79e-02	0.084300	2.68e-01
REACTOME NEF MEDIATED CD8 DOWN REGULATION	7	5.80e-02	0.414000	2.68e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS	5	5.82e-02	-0.489000	2.68e-01
REACTOME DIGESTION AND ABSORPTION	22	5.84e-02	-0.233000	2.68e-01
REACTOME MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS	7	5.85e-02	0.413000	2.68e-01
REACTOME REGULATION OF PTEN STABILITY AND ACTIVITY	67	5.86e-02	0.134000	2.68e-01
REACTOME INTERLEUKIN 12 FAMILY SIGNALING	53	5.89e-02	0.150000	2.68e-01
REACTOME TRANSCRIPTION OF THE HIV GENOME	66	5.90e-02	0.134000	2.68e-01
REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	5.90e-02	0.177000	2.68e-01
REACTOME PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	93	5.93e-02	0.113000	2.69e-01
REACTOME DISEASES OF BASE EXCISION REPAIR	5	5.98e-02	-0.486000	2.70e-01
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	13	5.99e-02	0.301000	2.70e-01
REACTOME FRUCTOSE METABOLISM	7	5.99e-02	-0.411000	2.70e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	25	6.13e-02	0.216000	2.75e-01
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	9	6.16e-02	0.360000	2.75e-01
REACTOME SMALL INTERFERING RNA SIRNA BIOGENESIS	9	6.18e-02	0.359000	2.75e-01
REACTOME INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	20	6.19e-02	0.241000	2.75e-01
REACTOME PHASE I FUNCTIONALIZATION OF COMPOUNDS	101	6.26e-02	-0.107000	2.78e-01
REACTOME ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	6.30e-02	0.135000	2.79e-01
REACTOME ABC TRANSPORTER DISORDERS	76	6.32e-02	0.123000	2.79e-01
REACTOME TRANSLESION SYNTHESIS BY POLK	17	6.34e-02	0.260000	2.79e-01
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	353	6.40e-02	0.057400	2.81e-01
REACTOME SIGNALING BY ALK	26	6.41e-02	0.210000	2.81e-01
REACTOME PREVENTION OF PHAGOSOMAL LYSOSOMAL FUSION	9	6.46e-02	0.356000	2.82e-01
REACTOME SARS COV 2 MODULATES HOST TRANSLATION MACHINERY	46	6.63e-02	0.156000	2.89e-01
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	6.65e-02	0.156000	2.89e-01
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	11	6.71e-02	0.319000	2.91e-01
REACTOME PROTEIN FOLDING	96	6.77e-02	0.108000	2.92e-01
REACTOME CELLULAR SENESCENCE	189	6.78e-02	0.077000	2.92e-01
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	49	6.84e-02	0.151000	2.93e-01
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	6.84e-02	0.211000	2.93e-01
REACTOME RECYCLING OF BILE ACIDS AND SALTS	18	6.86e-02	-0.248000	2.93e-01
REACTOME TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	76	6.89e-02	0.121000	2.93e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	6.90e-02	0.281000	2.93e-01
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	18	6.92e-02	-0.247000	2.93e-01
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	30	6.93e-02	0.192000	2.93e-01
REACTOME G1 S SPECIFIC TRANSCRIPTION	28	7.07e-02	0.197000	2.98e-01
REACTOME INTERLEUKIN 1 SIGNALING	110	7.09e-02	0.099700	2.99e-01
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	7.24e-02	0.196000	3.04e-01
REACTOME GLUCONEOGENESIS	33	7.29e-02	-0.180000	3.05e-01
REACTOME IKBA VARIANT LEADS TO EDA ID	6	7.33e-02	0.422000	3.06e-01
REACTOME DIGESTION	17	7.39e-02	-0.250000	3.08e-01
REACTOME MHC CLASS II ANTIGEN PRESENTATION	121	7.43e-02	0.093900	3.09e-01
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	56	7.47e-02	0.138000	3.10e-01
REACTOME INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA	11	7.50e-02	-0.310000	3.10e-01
REACTOME PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	7.55e-02	-0.310000	3.11e-01
REACTOME SCAVENGING BY CLASS A RECEPTORS	19	7.60e-02	-0.235000	3.11e-01
REACTOME HCMV INFECTION	152	7.60e-02	0.083400	3.11e-01
REACTOME POTENTIAL THERAPEUTICS FOR SARS	92	7.61e-02	0.107000	3.11e-01
REACTOME TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	82	7.62e-02	-0.113000	3.11e-01
REACTOME COPI MEDIATED ANTEROGRADE TRANSPORT	101	7.69e-02	0.102000	3.13e-01
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	8	7.90e-02	0.359000	3.21e-01
REACTOME HDR THROUGH MMEJ ALT NHEJ	12	7.94e-02	0.292000	3.22e-01
REACTOME ONCOGENE INDUCED SENESCENCE	35	7.97e-02	0.171000	3.22e-01
REACTOME MAPK FAMILY SIGNALING CASCADES	314	8.11e-02	0.057300	3.27e-01
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	24	8.17e-02	0.205000	3.29e-01
REACTOME CD209 DC SIGN SIGNALING	20	8.23e-02	0.224000	3.30e-01
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	118	8.32e-02	-0.092300	3.33e-01
REACTOME CGMP EFFECTS	16	8.34e-02	-0.250000	3.33e-01
REACTOME HOMOLOGY DIRECTED REPAIR	132	8.37e-02	0.087200	3.33e-01
REACTOME KERATAN SULFATE BIOSYNTHESIS	28	8.45e-02	-0.188000	3.36e-01
REACTOME INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	25	8.48e-02	0.199000	3.36e-01
REACTOME BH3 ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI APOPTOTIC BCL 2 MEMBERS	9	8.71e-02	0.329000	3.45e-01
REACTOME RA BIOSYNTHESIS PATHWAY	22	8.74e-02	0.211000	3.45e-01
REACTOME PEROXISOMAL PROTEIN IMPORT	62	8.77e-02	0.125000	3.45e-01
REACTOME DISSOLUTION OF FIBRIN CLOT	13	8.79e-02	-0.273000	3.45e-01
REACTOME HDR THROUGH SINGLE STRAND ANNEALING SSA	37	8.86e-02	0.162000	3.46e-01
REACTOME COLLAGEN DEGRADATION	61	8.86e-02	-0.126000	3.46e-01
REACTOME INSULIN PROCESSING	24	8.88e-02	0.201000	3.46e-01
REACTOME LRR FLII INTERACTING PROTEIN 1 LRRFIP1 ACTIVATES TYPE I IFN PRODUCTION	5	8.89e-02	0.439000	3.46e-01
REACTOME TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	39	9.11e-02	0.156000	3.53e-01
REACTOME RECEPTOR MEDIATED MITOPHAGY	10	9.13e-02	0.308000	3.53e-01
REACTOME EPH EPHRIN SIGNALING	90	9.23e-02	0.103000	3.56e-01
REACTOME EPHB MEDIATED FORWARD SIGNALING	41	9.25e-02	0.152000	3.56e-01
REACTOME TRANSCRIPTIONAL REGULATION BY SMALL RNAS	100	9.25e-02	0.097300	3.56e-01
REACTOME LONG TERM POTENTIATION	22	9.27e-02	-0.207000	3.56e-01
REACTOME SMAC XIAP REGULATED APOPTOTIC RESPONSE	7	9.40e-02	0.366000	3.60e-01
REACTOME HS GAG BIOSYNTHESIS	28	9.41e-02	-0.183000	3.60e-01
REACTOME POST TRANSCRIPTIONAL SILENCING BY SMALL RNAS	7	9.48e-02	0.365000	3.61e-01
REACTOME LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	11	9.56e-02	0.290000	3.63e-01
REACTOME REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA CARBOXYLATED PROTEINS	8	9.66e-02	-0.339000	3.66e-01
REACTOME DEFECTIVE F9 ACTIVATION	5	9.67e-02	-0.429000	3.66e-01
REACTOME SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	21	9.73e-02	-0.209000	3.66e-01
REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	11	9.73e-02	0.289000	3.66e-01
REACTOME TAK1 DEPENDENT IKK AND NF KAPPA B ACTIVATION	41	9.79e-02	0.149000	3.67e-01
REACTOME RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA	7	9.80e-02	0.361000	3.67e-01
REACTOME PROTEIN METHYLATION	17	9.83e-02	0.232000	3.68e-01
REACTOME MITOCHONDRIAL PROTEIN IMPORT	58	9.88e-02	0.125000	3.69e-01
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	40	9.94e-02	0.151000	3.70e-01
REACTOME FIBRONECTIN MATRIX FORMATION	6	1.01e-01	-0.387000	3.74e-01
REACTOME SIGNALING BY NOTCH3	48	1.01e-01	0.137000	3.74e-01
REACTOME DEFECTS IN COBALAMIN B12 METABOLISM	13	1.02e-01	0.262000	3.75e-01
REACTOME NGF STIMULATED TRANSCRIPTION	38	1.02e-01	0.153000	3.75e-01
REACTOME DEX H BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION	7	1.02e-01	0.357000	3.75e-01
REACTOME COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	65	1.02e-01	-0.117000	3.76e-01
REACTOME CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	13	1.03e-01	0.261000	3.77e-01
REACTOME LIPID PARTICLE ORGANIZATION	6	1.03e-01	0.384000	3.77e-01
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	1.04e-01	0.169000	3.79e-01
REACTOME SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	14	1.04e-01	0.251000	3.80e-01
REACTOME SELECTIVE AUTOPHAGY	79	1.05e-01	0.105000	3.82e-01
REACTOME FORMATION OF TC NER PRE INCISION COMPLEX	51	1.06e-01	0.131000	3.82e-01
REACTOME O LINKED GLYCOSYLATION	109	1.06e-01	-0.089700	3.82e-01
REACTOME SYNTHESIS OF PIPS AT THE ER MEMBRANE	5	1.06e-01	0.417000	3.83e-01
REACTOME HCMV EARLY EVENTS	128	1.06e-01	0.082700	3.83e-01
REACTOME TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	109	1.07e-01	0.089400	3.84e-01
REACTOME CYP2E1 REACTIONS	10	1.07e-01	-0.294000	3.84e-01
REACTOME REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	1.07e-01	0.280000	3.84e-01
REACTOME ANDROGEN BIOSYNTHESIS	11	1.09e-01	-0.279000	3.87e-01
REACTOME FANCONI ANEMIA PATHWAY	35	1.09e-01	0.156000	3.87e-01
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	123	1.10e-01	0.083500	3.87e-01
REACTOME INTERLEUKIN 18 SIGNALING	8	1.10e-01	0.327000	3.87e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES	8	1.10e-01	-0.326000	3.87e-01
REACTOME SUMOYLATION OF TRANSCRIPTION COFACTORS	43	1.10e-01	0.141000	3.87e-01
REACTOME SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	17	1.10e-01	-0.224000	3.87e-01
REACTOME PROTEIN REPAIR	6	1.10e-01	-0.376000	3.87e-01
REACTOME DEPOLYMERISATION OF THE NUCLEAR LAMINA	14	1.10e-01	0.246000	3.87e-01
REACTOME DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	76	1.11e-01	0.106000	3.89e-01
REACTOME GPVI MEDIATED ACTIVATION CASCADE	35	1.11e-01	0.156000	3.89e-01
REACTOME INTERLEUKIN 23 SIGNALING	9	1.12e-01	0.306000	3.89e-01
REACTOME COLLAGEN CHAIN TRIMERIZATION	42	1.12e-01	-0.142000	3.89e-01
REACTOME SIGNALING BY INTERLEUKINS	444	1.12e-01	0.044000	3.89e-01
REACTOME RRNA PROCESSING IN THE MITOCHONDRION	9	1.13e-01	0.305000	3.90e-01
REACTOME SIGNALING BY ACTIVIN	15	1.13e-01	0.237000	3.90e-01
REACTOME GAP JUNCTION DEGRADATION	12	1.14e-01	0.264000	3.92e-01
REACTOME NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	1.14e-01	0.157000	3.92e-01
REACTOME NERVOUS SYSTEM DEVELOPMENT	552	1.14e-01	0.039300	3.92e-01
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	15	1.15e-01	0.235000	3.93e-01
REACTOME ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS	5	1.16e-01	-0.406000	3.96e-01
REACTOME SIGNALING BY INSULIN RECEPTOR	80	1.16e-01	0.102000	3.97e-01
REACTOME ESTROGEN DEPENDENT GENE EXPRESSION	140	1.17e-01	0.076800	3.97e-01
REACTOME RIP MEDIATED NFKB ACTIVATION VIA ZBP1	16	1.17e-01	0.226000	3.98e-01
REACTOME ER TO GOLGI ANTEROGRADE TRANSPORT	152	1.18e-01	0.073500	4.00e-01
REACTOME INFLAMMASOMES	21	1.18e-01	-0.197000	4.00e-01
REACTOME SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	8	1.19e-01	0.319000	4.01e-01
REACTOME DNA DAMAGE BYPASS	47	1.20e-01	0.131000	4.02e-01
REACTOME GLUTATHIONE CONJUGATION	33	1.20e-01	-0.157000	4.02e-01
REACTOME HCMV LATE EVENTS	110	1.22e-01	0.085400	4.09e-01
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	5	1.22e-01	-0.399000	4.09e-01
REACTOME DEFECTIVE CHSY1 CAUSES TPBS	7	1.22e-01	0.337000	4.09e-01
REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	21	1.23e-01	-0.195000	4.09e-01
REACTOME RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION	6	1.23e-01	0.364000	4.09e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	25	1.23e-01	0.178000	4.09e-01
REACTOME DISEASES OF IMMUNE SYSTEM	29	1.24e-01	0.165000	4.10e-01
REACTOME G BETA GAMMA SIGNALLING THROUGH CDC42	19	1.24e-01	0.204000	4.10e-01
REACTOME COMPLEX I BIOGENESIS	49	1.24e-01	0.127000	4.10e-01
REACTOME COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	98	1.24e-01	0.089800	4.10e-01
REACTOME EUKARYOTIC TRANSLATION ELONGATION	87	1.25e-01	0.095200	4.10e-01
REACTOME TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	29	1.25e-01	0.165000	4.10e-01
REACTOME SIGNALING BY NOTCH1 T 7 9 NOTCH1 M1580 K2555 TRANSLOCATION MUTANT	7	1.26e-01	0.334000	4.13e-01
REACTOME SIGNALING BY HEDGEHOG	148	1.26e-01	0.072800	4.13e-01
REACTOME RUNX3 REGULATES NOTCH SIGNALING	13	1.27e-01	0.245000	4.14e-01
REACTOME SYNAPTIC ADHESION LIKE MOLECULES	19	1.28e-01	-0.202000	4.16e-01
REACTOME DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS	25	1.28e-01	0.176000	4.17e-01
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	46	1.29e-01	0.129000	4.19e-01
REACTOME COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	38	1.29e-01	0.142000	4.19e-01
REACTOME CREB3 FACTORS ACTIVATE GENES	8	1.32e-01	0.308000	4.25e-01
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	9	1.32e-01	-0.290000	4.25e-01
REACTOME ERKS ARE INACTIVATED	13	1.32e-01	0.241000	4.25e-01
REACTOME BASIGIN INTERACTIONS	24	1.33e-01	0.177000	4.27e-01
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	67	1.34e-01	0.106000	4.29e-01
REACTOME TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	55	1.35e-01	0.117000	4.31e-01
REACTOME ATORVASTATIN ADME	9	1.35e-01	-0.288000	4.31e-01
REACTOME MEIOSIS	110	1.36e-01	0.082300	4.33e-01
REACTOME ESTABLISHMENT OF SISTER CHROMATID COHESION	9	1.37e-01	0.286000	4.36e-01
REACTOME GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	81	1.37e-01	0.095500	4.36e-01
REACTOME SYNTHESIS OF 15 EICOSATETRAENOIC ACID DERIVATIVES	6	1.37e-01	0.350000	4.36e-01
REACTOME RECYCLING OF EIF2 GDP	7	1.38e-01	0.323000	4.36e-01
REACTOME REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	19	1.38e-01	0.196000	4.36e-01
REACTOME CYTOPROTECTION BY HMOX1	59	1.38e-01	0.112000	4.36e-01
REACTOME REGULATION OF NF KAPPA B SIGNALING	17	1.39e-01	0.207000	4.36e-01
REACTOME NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	25	1.39e-01	0.171000	4.36e-01
REACTOME FORMATION OF AXIAL MESODERM	14	1.39e-01	0.228000	4.36e-01
REACTOME HDMS DEMETHYLATE HISTONES	40	1.40e-01	0.135000	4.36e-01
REACTOME CHYLOMICRON REMODELING	10	1.40e-01	-0.270000	4.36e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	20	1.41e-01	0.190000	4.36e-01
REACTOME SYNTHESIS OF PC	27	1.41e-01	0.164000	4.36e-01
REACTOME MRNA EDITING	10	1.42e-01	0.268000	4.36e-01
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	36	1.42e-01	0.142000	4.36e-01
REACTOME REGULATION OF IFNG SIGNALING	14	1.42e-01	0.227000	4.36e-01
REACTOME PROCESSING OF SMDT1	16	1.42e-01	0.212000	4.36e-01
REACTOME DUAL INCISION IN GG NER	39	1.42e-01	0.136000	4.36e-01
REACTOME TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION	12	1.42e-01	0.245000	4.36e-01
REACTOME VLDLR INTERNALISATION AND DEGRADATION	16	1.43e-01	0.212000	4.36e-01
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	19	1.43e-01	0.194000	4.36e-01
REACTOME CTLA4 INHIBITORY SIGNALING	21	1.43e-01	0.185000	4.36e-01
REACTOME SARS COV 1 HOST INTERACTIONS	92	1.43e-01	0.088400	4.36e-01
REACTOME FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS	8	1.43e-01	-0.299000	4.37e-01
REACTOME ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	68	1.44e-01	0.102000	4.37e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION	102	1.44e-01	0.083700	4.37e-01
REACTOME SELENOAMINO ACID METABOLISM	108	1.44e-01	0.081300	4.38e-01
REACTOME RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	1.45e-01	0.086900	4.38e-01
REACTOME PI METABOLISM	79	1.45e-01	0.094700	4.38e-01
REACTOME DEFECTIVE RIPK1 MEDIATED REGULATED NECROSIS	7	1.46e-01	0.317000	4.38e-01
REACTOME CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	12	1.46e-01	0.242000	4.38e-01
REACTOME EXTRA NUCLEAR ESTROGEN SIGNALING	74	1.46e-01	0.097700	4.38e-01
REACTOME PHASE II CONJUGATION OF COMPOUNDS	102	1.47e-01	-0.083200	4.38e-01
REACTOME SARS COV 1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS	16	1.47e-01	0.210000	4.38e-01
REACTOME FERTILIZATION	26	1.47e-01	-0.164000	4.38e-01
REACTOME XENOBIOTICS	22	1.47e-01	-0.178000	4.38e-01
REACTOME GOLGI TO ER RETROGRADE TRANSPORT	132	1.47e-01	0.073000	4.38e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF SATURATED FATTY ACIDS	11	1.47e-01	-0.252000	4.38e-01
REACTOME AMYLOID FIBER FORMATION	102	1.48e-01	0.082900	4.38e-01
REACTOME CLEC7A INFLAMMASOME PATHWAY	6	1.48e-01	0.341000	4.38e-01
REACTOME MRNA CAPPING	28	1.48e-01	0.158000	4.38e-01
REACTOME HDL ASSEMBLY	8	1.49e-01	0.295000	4.39e-01
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	28	1.49e-01	0.157000	4.39e-01
REACTOME MATURATION OF SARS COV 2 NUCLEOPROTEIN	15	1.51e-01	0.214000	4.42e-01
REACTOME GLUCOSE METABOLISM	90	1.51e-01	0.087600	4.42e-01
REACTOME P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1	6	1.51e-01	0.338000	4.42e-01
REACTOME ABC TRANSPORTERS IN LIPID HOMEOSTASIS	17	1.52e-01	0.201000	4.44e-01
REACTOME PI5P REGULATES TP53 ACETYLATION	9	1.53e-01	0.275000	4.45e-01
REACTOME APOPTOTIC FACTOR MEDIATED RESPONSE	19	1.53e-01	0.189000	4.45e-01
REACTOME LOSS OF FUNCTION OF SMAD2 3 IN CANCER	7	1.53e-01	0.312000	4.45e-01
REACTOME NONHOMOLOGOUS END JOINING NHEJ	64	1.54e-01	0.103000	4.46e-01
REACTOME CELL JUNCTION ORGANIZATION	89	1.55e-01	-0.087100	4.50e-01
REACTOME HEDGEHOG OFF STATE	111	1.56e-01	0.078000	4.50e-01
REACTOME FORMATION OF PARAXIAL MESODERM	22	1.56e-01	0.175000	4.50e-01
REACTOME RETINOID CYCLE DISEASE EVENTS	11	1.56e-01	-0.247000	4.50e-01
REACTOME ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	20	1.57e-01	0.183000	4.52e-01
REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	22	1.58e-01	0.174000	4.54e-01
REACTOME VITAMIN D CALCIFEROL METABOLISM	12	1.58e-01	0.235000	4.54e-01
REACTOME CD28 CO STIMULATION	32	1.59e-01	0.144000	4.54e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	20	1.59e-01	0.182000	4.54e-01
REACTOME SIGNALING BY ALK IN CANCER	53	1.59e-01	0.112000	4.54e-01
REACTOME COLLAGEN FORMATION	88	1.60e-01	-0.086700	4.54e-01
REACTOME CYTOSOLIC TRNA AMINOACYLATION	22	1.60e-01	0.173000	4.56e-01
REACTOME EFFECTS OF PIP2 HYDROLYSIS	26	1.61e-01	0.159000	4.58e-01
REACTOME SARS COV 2 MODULATES AUTOPHAGY	11	1.62e-01	0.244000	4.58e-01
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	37	1.62e-01	-0.133000	4.58e-01
REACTOME RAF ACTIVATION	33	1.62e-01	0.141000	4.58e-01
REACTOME TBC RABGAPS	40	1.64e-01	0.127000	4.62e-01
REACTOME RAF INDEPENDENT MAPK1 3 ACTIVATION	22	1.65e-01	0.171000	4.62e-01
REACTOME HDACS DEACETYLATE HISTONES	85	1.65e-01	0.087100	4.62e-01
REACTOME G PROTEIN ACTIVATION	24	1.65e-01	0.164000	4.62e-01
REACTOME TELOMERE EXTENSION BY TELOMERASE	22	1.65e-01	0.171000	4.62e-01
REACTOME REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	11	1.66e-01	0.241000	4.62e-01
REACTOME SIGNALING BY NODAL	20	1.70e-01	0.177000	4.74e-01
REACTOME FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	85	1.71e-01	0.086000	4.74e-01
REACTOME INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	21	1.71e-01	-0.173000	4.74e-01
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	16	1.72e-01	0.197000	4.78e-01
REACTOME KETONE BODY METABOLISM	9	1.73e-01	-0.262000	4.79e-01
REACTOME SIGNALING BY RETINOIC ACID	41	1.74e-01	0.123000	4.79e-01
REACTOME NUCLEOTIDE BIOSYNTHESIS	14	1.74e-01	0.210000	4.79e-01
REACTOME MIRO GTPASE CYCLE	8	1.74e-01	0.277000	4.81e-01
REACTOME ORGANIC CATION TRANSPORT	10	1.76e-01	-0.247000	4.84e-01
REACTOME CLATHRIN MEDIATED ENDOCYTOSIS	139	1.77e-01	0.066400	4.85e-01
REACTOME RHO GTPASES ACTIVATE CIT	19	1.78e-01	0.178000	4.88e-01
REACTOME SYNTHESIS OF GDP MANNOSE	5	1.79e-01	0.347000	4.88e-01
REACTOME NEPHRIN FAMILY INTERACTIONS	22	1.79e-01	-0.165000	4.88e-01
REACTOME SIGNALING BY BMP	27	1.79e-01	0.149000	4.88e-01
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	183	1.80e-01	0.057500	4.88e-01
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	29	1.80e-01	0.144000	4.88e-01
REACTOME FGFR2 ALTERNATIVE SPLICING	27	1.80e-01	0.149000	4.89e-01
REACTOME WAX AND PLASMALOGEN BIOSYNTHESIS	5	1.81e-01	0.345000	4.90e-01
REACTOME SHC1 EVENTS IN ERBB2 SIGNALING	22	1.81e-01	-0.165000	4.90e-01
REACTOME NTRK2 ACTIVATES RAC1	5	1.82e-01	-0.345000	4.90e-01
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	299	1.82e-01	0.044900	4.90e-01
REACTOME CS DS DEGRADATION	12	1.82e-01	0.222000	4.91e-01
REACTOME INTERLEUKIN 27 SIGNALING	11	1.83e-01	0.232000	4.91e-01
REACTOME IRS MEDIATED SIGNALLING	47	1.83e-01	0.112000	4.92e-01
REACTOME INTERFERON GAMMA SIGNALING	88	1.84e-01	0.082000	4.92e-01
REACTOME REGULATION OF BETA CELL DEVELOPMENT	41	1.84e-01	0.120000	4.93e-01
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	62	1.86e-01	-0.097100	4.96e-01
REACTOME PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	1.86e-01	0.167000	4.96e-01
REACTOME RESPONSE OF MTB TO PHAGOCYTOSIS	22	1.87e-01	0.163000	4.96e-01
REACTOME TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	71	1.88e-01	0.090400	4.99e-01
REACTOME SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	1.88e-01	0.196000	4.99e-01
REACTOME EGFR DOWNREGULATION	30	1.89e-01	-0.139000	5.00e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	1.90e-01	0.195000	5.03e-01
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	29	1.93e-01	0.140000	5.10e-01
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	11	1.94e-01	0.226000	5.10e-01
REACTOME SIGNALING BY NTRKS	132	1.94e-01	0.065400	5.10e-01
REACTOME PARACETAMOL ADME	26	1.95e-01	-0.147000	5.10e-01
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	1.95e-01	0.226000	5.10e-01
REACTOME SIGNALING BY ERBB2 IN CANCER	26	1.95e-01	-0.147000	5.10e-01
REACTOME STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	16	1.95e-01	-0.187000	5.10e-01
REACTOME SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	52	1.97e-01	0.103000	5.13e-01
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	16	1.97e-01	-0.186000	5.13e-01
REACTOME ER QUALITY CONTROL COMPARTMENT ERQC	21	1.99e-01	0.162000	5.17e-01
REACTOME LDL CLEARANCE	19	1.99e-01	0.170000	5.17e-01
REACTOME CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.99e-01	0.214000	5.17e-01
REACTOME NOSTRIN MEDIATED ENOS TRAFFICKING	5	2.00e-01	0.331000	5.17e-01
REACTOME VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	42	2.00e-01	0.114000	5.17e-01
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX IN CANCER	8	2.01e-01	0.261000	5.17e-01
REACTOME TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	30	2.01e-01	0.135000	5.17e-01
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH RAS	8	2.01e-01	-0.261000	5.17e-01
REACTOME HDL REMODELING	10	2.01e-01	0.233000	5.17e-01
REACTOME DNA DOUBLE STRAND BREAK RESPONSE	74	2.02e-01	0.085900	5.17e-01
REACTOME RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	47	2.02e-01	0.107000	5.17e-01
REACTOME SIGNAL AMPLIFICATION	33	2.02e-01	0.128000	5.17e-01
REACTOME ELASTIC FIBRE FORMATION	44	2.03e-01	-0.111000	5.17e-01
REACTOME SHC1 EVENTS IN EGFR SIGNALING	14	2.03e-01	-0.197000	5.17e-01
REACTOME PROTON COUPLED MONOCARBOXYLATE TRANSPORT	6	2.04e-01	0.299000	5.20e-01
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	15	2.05e-01	0.189000	5.20e-01
REACTOME UBIQUINOL BIOSYNTHESIS	8	2.06e-01	0.258000	5.22e-01
REACTOME CHOLINE CATABOLISM	6	2.06e-01	0.298000	5.22e-01
REACTOME ZINC TRANSPORTERS	15	2.06e-01	0.188000	5.22e-01
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	91	2.07e-01	-0.076600	5.22e-01
REACTOME HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	43	2.08e-01	0.111000	5.25e-01
REACTOME BIOTIN TRANSPORT AND METABOLISM	10	2.08e-01	-0.230000	5.25e-01
REACTOME RHO GTPASES ACTIVATE PAKS	19	2.09e-01	0.166000	5.25e-01
REACTOME RHOD GTPASE CYCLE	49	2.09e-01	-0.104000	5.25e-01
REACTOME SYNTHESIS OF PG	8	2.10e-01	0.256000	5.26e-01
REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	2.10e-01	-0.176000	5.26e-01
REACTOME MET RECEPTOR ACTIVATION	6	2.11e-01	-0.295000	5.26e-01
REACTOME ATTACHMENT AND ENTRY	16	2.11e-01	-0.181000	5.26e-01
REACTOME METABOLISM OF COFACTORS	19	2.11e-01	0.166000	5.26e-01
REACTOME PROLONGED ERK ACTIVATION EVENTS	14	2.12e-01	0.193000	5.28e-01
REACTOME DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1	9	2.13e-01	-0.240000	5.30e-01
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	11	2.15e-01	0.216000	5.33e-01
REACTOME DISEASES OF PROGRAMMED CELL DEATH	96	2.15e-01	0.073200	5.33e-01
REACTOME SYNTHESIS OF KETONE BODIES	8	2.16e-01	-0.253000	5.34e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS	9	2.17e-01	-0.238000	5.35e-01
REACTOME RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS	5	2.17e-01	-0.319000	5.35e-01
REACTOME TRIGLYCERIDE CATABOLISM	23	2.18e-01	0.148000	5.36e-01
REACTOME HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	66	2.19e-01	0.087600	5.37e-01
REACTOME HDL CLEARANCE	5	2.19e-01	0.318000	5.37e-01
REACTOME REGULATION OF NPAS4 MRNA TRANSLATION	9	2.19e-01	0.237000	5.37e-01
REACTOME GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	34	2.20e-01	0.121000	5.38e-01
REACTOME PLATELET SENSITIZATION BY LDL	17	2.20e-01	0.172000	5.38e-01
REACTOME REGULATION OF PTEN MRNA TRANSLATION	9	2.22e-01	0.235000	5.42e-01
REACTOME BETA OXIDATION OF BUTANOYL COA TO ACETYL COA	5	2.23e-01	-0.315000	5.42e-01
REACTOME P75NTR SIGNALS VIA NF KB	15	2.23e-01	0.182000	5.42e-01
REACTOME WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	2.25e-01	0.194000	5.45e-01
REACTOME SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	27	2.25e-01	0.135000	5.45e-01
REACTOME ERBB2 ACTIVATES PTK6 SIGNALING	13	2.25e-01	-0.194000	5.45e-01
REACTOME SIALIC ACID METABOLISM	33	2.25e-01	-0.122000	5.45e-01
REACTOME CARDIAC CONDUCTION	125	2.27e-01	-0.062600	5.45e-01
REACTOME PHOSPHORYLATION OF THE APC C	20	2.28e-01	0.156000	5.45e-01
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	250	2.28e-01	0.044300	5.45e-01
REACTOME GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	30	2.28e-01	-0.127000	5.45e-01
REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	2.28e-01	0.210000	5.45e-01
REACTOME DOPAMINE RECEPTORS	5	2.29e-01	-0.311000	5.45e-01
REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	2.29e-01	0.193000	5.45e-01
REACTOME DEATH RECEPTOR SIGNALING	143	2.29e-01	0.058300	5.45e-01
REACTOMEMATURATION OF SARS COV 1 NUCLEOPROTEIN	11	2.29e-01	0.209000	5.45e-01
REACTOME PREGNENOLONE BIOSYNTHESIS	12	2.29e-01	-0.201000	5.45e-01
REACTOME FCERI MEDIATED MAPK ACTIVATION	32	2.29e-01	0.123000	5.45e-01
REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	16	2.30e-01	0.173000	5.45e-01
REACTOME RRNA MODIFICATION IN THE MITOCHONDRION	6	2.30e-01	0.283000	5.45e-01
REACTOME COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	21	2.30e-01	0.151000	5.45e-01
REACTOME MEIOTIC SYNAPSIS	73	2.30e-01	0.081200	5.45e-01
REACTOME COHESIN LOADING ONTO CHROMATIN	8	2.31e-01	0.244000	5.45e-01
REACTOME POU5F1 OCT4 SOX2 NANOG ACTIVATE GENES RELATED TO PROLIFERATION	11	2.32e-01	0.208000	5.45e-01
REACTOME G ALPHA Q SIGNALLING EVENTS	206	2.32e-01	0.048300	5.45e-01
REACTOME REGULATION OF NPAS4 GENE EXPRESSION	13	2.32e-01	0.192000	5.45e-01
REACTOME AMINE LIGAND BINDING RECEPTORS	40	2.32e-01	-0.109000	5.46e-01
REACTOME SIGNALING BY MST1	5	2.34e-01	-0.307000	5.48e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	2.35e-01	0.172000	5.48e-01
REACTOME METABOLISM OF LIPIDS	709	2.35e-01	0.026200	5.48e-01
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	14	2.35e-01	-0.183000	5.48e-01
REACTOME RHOBTB2 GTPASE CYCLE	22	2.35e-01	0.146000	5.48e-01
REACTOME FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	83	2.35e-01	0.075400	5.48e-01
REACTOME TOXICITY OF BOTULINUM TOXIN TYPE D BOTD	5	2.36e-01	0.306000	5.49e-01
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	12	2.37e-01	-0.197000	5.49e-01
REACTOME NICOTINATE METABOLISM	31	2.37e-01	0.123000	5.49e-01
REACTOME NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY	6	2.37e-01	0.279000	5.50e-01
REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	45	2.39e-01	0.102000	5.52e-01
REACTOME RAB GERANYLGERANYLATION	57	2.39e-01	0.090100	5.52e-01
REACTOME REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	2.41e-01	-0.214000	5.55e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	15	2.41e-01	-0.175000	5.55e-01
REACTOME SERINE BIOSYNTHESIS	9	2.41e-01	0.226000	5.55e-01
REACTOME KERATAN SULFATE DEGRADATION	13	2.42e-01	-0.187000	5.57e-01
REACTOME MRNA EDITING C TO U CONVERSION	8	2.43e-01	0.239000	5.57e-01
REACTOME NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	100	2.45e-01	0.067300	5.58e-01
REACTOME SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	104	2.45e-01	0.066000	5.58e-01
REACTOME SODIUM COUPLED SULPHATE DI AND TRI CARBOXYLATE TRANSPORTERS	5	2.45e-01	-0.300000	5.58e-01
REACTOME CARGO CONCENTRATION IN THE ER	32	2.45e-01	-0.119000	5.58e-01
REACTOME BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	19	2.45e-01	-0.154000	5.58e-01
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	15	2.46e-01	-0.173000	5.59e-01
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	89	2.46e-01	0.071100	5.59e-01
REACTOME ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	41	2.46e-01	-0.105000	5.59e-01
REACTOME SARS COV 2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS	12	2.48e-01	0.193000	5.61e-01
REACTOME N GLYCAN ANTENNAE ELONGATION	15	2.49e-01	-0.172000	5.63e-01
REACTOME LYSOSOME VESICLE BIOGENESIS	33	2.50e-01	0.116000	5.64e-01
REACTOME METABOLISM OF VITAMINS AND COFACTORS	185	2.50e-01	0.049100	5.64e-01
REACTOME INTERLEUKIN 12 SIGNALING	43	2.51e-01	0.101000	5.64e-01
REACTOME REGULATION OF GENE EXPRESSION IN ENDOCRINE COMMITTED NEUROG3 PROGENITOR CELLS	5	2.51e-01	0.296000	5.65e-01
REACTOME MITOCHONDRIAL BIOGENESIS	87	2.53e-01	0.070900	5.69e-01
REACTOME TRIGLYCERIDE METABOLISM	35	2.53e-01	0.112000	5.69e-01
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	24	2.54e-01	0.135000	5.69e-01
REACTOME CREATINE METABOLISM	9	2.55e-01	0.219000	5.71e-01
REACTOME GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	14	2.56e-01	0.175000	5.71e-01
REACTOME INSULIN RECEPTOR RECYCLING	29	2.56e-01	0.122000	5.71e-01
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	23	2.58e-01	0.136000	5.74e-01
REACTOME VOLTAGE GATED POTASSIUM CHANNELS	42	2.58e-01	-0.101000	5.74e-01
REACTOME PYRIMIDINE CATABOLISM	12	2.59e-01	-0.188000	5.75e-01
REACTOME NR1H2 AND NR1H3 MEDIATED SIGNALING	46	2.59e-01	0.096200	5.75e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	121	2.60e-01	0.059300	5.75e-01
REACTOME ACETYLCHOLINE REGULATES INSULIN SECRETION	10	2.60e-01	-0.206000	5.75e-01
REACTOME FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	29	2.61e-01	0.121000	5.75e-01
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	188	2.61e-01	0.047500	5.75e-01
REACTOME REGULATION OF IFNA IFNB SIGNALING	23	2.61e-01	0.135000	5.75e-01
REACTOME DISEASES OF METABOLISM	237	2.61e-01	-0.042400	5.75e-01
REACTOME DEFECTIVE EXT2 CAUSES EXOSTOSES 2	12	2.62e-01	-0.187000	5.75e-01
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	39	2.62e-01	-0.104000	5.75e-01
REACTOME ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	20	2.62e-01	0.145000	5.75e-01
REACTOME ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA	9	2.63e-01	0.215000	5.77e-01
REACTOME THE PHOTOTRANSDUCTION CASCADE	32	2.64e-01	0.114000	5.77e-01
REACTOME NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES	7	2.65e-01	0.243000	5.78e-01
REACTOME CD22 MEDIATED BCR REGULATION	5	2.65e-01	0.288000	5.78e-01
REACTOME REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS	8	2.67e-01	0.227000	5.80e-01
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	53	2.67e-01	0.088200	5.80e-01
REACTOME GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	35	2.68e-01	0.108000	5.81e-01
REACTOME PREDNISONE ADME	10	2.68e-01	-0.202000	5.81e-01
REACTOME SIGNALING BY MAPK MUTANTS	6	2.68e-01	0.261000	5.81e-01
REACTOME SUMOYLATION OF IMMUNE RESPONSE PROTEINS	10	2.69e-01	0.202000	5.81e-01
REACTOME DEFECTIVE LFNG CAUSES SCDO3	5	2.69e-01	0.285000	5.81e-01
REACTOME SIGNALING BY ERBB2 ECD MUTANTS	16	2.70e-01	-0.159000	5.82e-01
REACTOME KERATAN SULFATE KERATIN METABOLISM	34	2.71e-01	-0.109000	5.82e-01
REACTOME IRF3 MEDIATED INDUCTION OF TYPE I IFN	13	2.71e-01	-0.176000	5.82e-01
REACTOME PYRIMIDINE SALVAGE	10	2.72e-01	-0.201000	5.82e-01
REACTOME MUSCARINIC ACETYLCHOLINE RECEPTORS	5	2.72e-01	-0.284000	5.82e-01
REACTOME CALNEXIN CALRETICULIN CYCLE	26	2.72e-01	0.124000	5.82e-01
REACTOME BASE EXCISION REPAIR	87	2.72e-01	0.068100	5.82e-01
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	112	2.72e-01	0.060000	5.82e-01
REACTOME DISEASES OF MITOTIC CELL CYCLE	37	2.73e-01	0.104000	5.83e-01
REACTOME PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING	5	2.73e-01	-0.283000	5.83e-01
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	14	2.74e-01	-0.169000	5.84e-01
REACTOME RHOB GTPASE CYCLE	67	2.75e-01	-0.077200	5.84e-01
REACTOME PHASE 4 RESTING MEMBRANE POTENTIAL	19	2.75e-01	-0.145000	5.84e-01
REACTOME PROLACTIN RECEPTOR SIGNALING	15	2.76e-01	-0.163000	5.84e-01
REACTOME INDUCTION OF CELL CELL FUSION	12	2.76e-01	-0.182000	5.84e-01
REACTOME TRANSCRIPTIONAL REGULATION BY MECP2	60	2.76e-01	0.081300	5.84e-01
REACTOME ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	2.77e-01	0.162000	5.84e-01
REACTOME INHIBITION OF DNA RECOMBINATION AT TELOMERE	63	2.77e-01	0.079200	5.84e-01
REACTOME RHOT1 GTPASE CYCLE	5	2.77e-01	0.281000	5.84e-01
REACTOME METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	122	2.77e-01	0.056900	5.84e-01
REACTOME ACTIVATION OF CASPASES THROUGH APOPTOSOME MEDIATED CLEAVAGE	5	2.78e-01	0.280000	5.84e-01
REACTOME INTERLEUKIN 9 SIGNALING	7	2.78e-01	0.237000	5.84e-01
REACTOME PLATELET CALCIUM HOMEOSTASIS	27	2.79e-01	0.120000	5.85e-01
REACTOME TRANSCRIPTIONAL REGULATION BY VENTX	41	2.79e-01	0.097600	5.85e-01
REACTOME DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS	14	2.80e-01	-0.167000	5.85e-01
REACTOME DARPP 32 EVENTS	24	2.80e-01	0.127000	5.85e-01
REACTOME ENDOSOMAL VACUOLAR PATHWAY	11	2.80e-01	0.188000	5.85e-01
REACTOME METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	2.83e-01	0.160000	5.87e-01
REACTOME ACTIVATION OF RAS IN B CELLS	5	2.83e-01	-0.277000	5.87e-01
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	10	2.83e-01	0.196000	5.87e-01
REACTOME TRANSCRIPTIONAL REGULATION BY E2F6	32	2.83e-01	0.110000	5.87e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	34	2.83e-01	0.106000	5.87e-01
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	16	2.84e-01	-0.155000	5.87e-01
REACTOME SARS COV 1 MODULATES HOST TRANSLATION MACHINERY	33	2.84e-01	0.108000	5.88e-01
REACTOME UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES	9	2.87e-01	0.205000	5.93e-01
REACTOME NEF MEDIATED CD4 DOWN REGULATION	9	2.87e-01	0.205000	5.93e-01
REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	17	2.88e-01	0.149000	5.93e-01
REACTOME DNA DAMAGE RECOGNITION IN GG NER	36	2.88e-01	0.102000	5.93e-01
REACTOME ERK MAPK TARGETS	20	2.89e-01	0.137000	5.93e-01
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	21	2.89e-01	0.134000	5.93e-01
REACTOME OAS ANTIVIRAL RESPONSE	8	2.90e-01	0.216000	5.94e-01
REACTOME APOPTOTIC EXECUTION PHASE	49	2.91e-01	0.087100	5.96e-01
REACTOME PHOSPHORYLATION OF EMI1	6	2.92e-01	0.248000	5.97e-01
REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	22	2.94e-01	0.129000	5.99e-01
REACTOME NONCANONICAL ACTIVATION OF NOTCH3	8	2.94e-01	0.214000	5.99e-01
REACTOME ACTIVATION OF NIMA KINASES NEK9 NEK6 NEK7	7	2.94e-01	0.229000	5.99e-01
REACTOME ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	113	2.94e-01	0.057100	5.99e-01
REACTOME PHENYLALANINE AND TYROSINE METABOLISM	11	2.95e-01	-0.182000	6.00e-01
REACTOME RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	16	2.96e-01	-0.151000	6.00e-01
REACTOME ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	23	2.96e-01	0.126000	6.00e-01
REACTOME FRUCTOSE CATABOLISM	5	2.97e-01	-0.269000	6.01e-01
REACTOME SULFUR AMINO ACID METABOLISM	27	2.97e-01	0.116000	6.01e-01
REACTOME RAS PROCESSING	22	2.98e-01	0.128000	6.01e-01
REACTOME RORA ACTIVATES GENE EXPRESSION	17	2.98e-01	0.146000	6.01e-01
REACTOME ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION	62	2.99e-01	0.076300	6.01e-01
REACTOME OTHER SEMAPHORIN INTERACTIONS	18	2.99e-01	-0.141000	6.01e-01
REACTOME CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	2.99e-01	-0.181000	6.01e-01
REACTOME FLT3 SIGNALING	38	2.99e-01	0.097300	6.01e-01
REACTOME NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	3.00e-01	0.173000	6.02e-01
REACTOME GLUTAMATE AND GLUTAMINE METABOLISM	13	3.01e-01	0.166000	6.04e-01
REACTOME TRANSCRIPTIONAL REGULATION BY NPAS4	33	3.02e-01	0.104000	6.04e-01
REACTOME DISINHIBITION OF SNARE FORMATION	5	3.03e-01	0.266000	6.05e-01
REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	23	3.03e-01	0.124000	6.05e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FYN	7	3.06e-01	-0.223000	6.10e-01
REACTOME INTEGRATION OF PROVIRUS	9	3.07e-01	0.197000	6.11e-01
REACTOME RUNX3 REGULATES BCL2L11 BIM TRANSCRIPTION	5	3.10e-01	0.262000	6.15e-01
REACTOME TRANSCRIPTIONAL REGULATION BY RUNX1	229	3.10e-01	0.038900	6.15e-01
REACTOME MATURATION OF SARS COV 2 SPIKE PROTEIN	35	3.10e-01	0.099100	6.15e-01
REACTOME MET ACTIVATES RAS SIGNALING	11	3.11e-01	-0.176000	6.16e-01
REACTOME REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	3.11e-01	0.151000	6.16e-01
REACTOME MASTL FACILITATES MITOTIC PROGRESSION	10	3.16e-01	0.183000	6.24e-01
REACTOME RHOC GTPASE CYCLE	71	3.16e-01	-0.068800	6.24e-01
REACTOME ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	3.17e-01	0.183000	6.24e-01
REACTOME RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION	8	3.18e-01	-0.204000	6.24e-01
REACTOME THE NLRP3 INFLAMMASOME	16	3.18e-01	-0.144000	6.24e-01
REACTOME SODIUM PROTON EXCHANGERS	7	3.18e-01	0.218000	6.24e-01
REACTOME LGI ADAM INTERACTIONS	14	3.19e-01	-0.154000	6.25e-01
REACTOME RHOV GTPASE CYCLE	36	3.19e-01	0.096000	6.25e-01
REACTOME CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	77	3.19e-01	-0.065700	6.25e-01
REACTOME RHOF GTPASE CYCLE	40	3.20e-01	-0.090900	6.25e-01
REACTOME BUTYROPHILIN BTN FAMILY INTERACTIONS	12	3.20e-01	-0.166000	6.25e-01
REACTOME TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE	10	3.22e-01	0.181000	6.27e-01
REACTOME TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	41	3.22e-01	0.089400	6.27e-01
REACTOME CA2 ACTIVATED K CHANNELS	9	3.22e-01	0.191000	6.27e-01
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	3.23e-01	0.080000	6.28e-01
REACTOME ERBB2 REGULATES CELL MOTILITY	15	3.24e-01	-0.147000	6.28e-01
REACTOME SIGNALING BY FGFR2 IN DISEASE	42	3.24e-01	0.087900	6.29e-01
REACTOME ACYL CHAIN REMODELLING OF PS	22	3.25e-01	-0.121000	6.29e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	27	3.25e-01	0.109000	6.29e-01
REACTOME ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY	5	3.26e-01	0.254000	6.29e-01
REACTOME MET ACTIVATES PTK2 SIGNALING	30	3.26e-01	-0.104000	6.29e-01
REACTOME RND2 GTPASE CYCLE	42	3.26e-01	0.087500	6.29e-01
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	255	3.29e-01	-0.035500	6.32e-01
REACTOME ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	13	3.29e-01	-0.156000	6.32e-01
REACTOME DEFECTS IN BIOTIN BTN METABOLISM	8	3.29e-01	-0.199000	6.32e-01
REACTOME REGULATION OF FZD BY UBIQUITINATION	21	3.31e-01	-0.123000	6.34e-01
REACTOME INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	14	3.31e-01	-0.150000	6.34e-01
REACTOME EGFR INTERACTS WITH PHOSPHOLIPASE C GAMMA	9	3.32e-01	-0.187000	6.35e-01
REACTOME PEXOPHAGY	11	3.32e-01	0.169000	6.35e-01
REACTOME SIGNALING BY FGFR IN DISEASE	62	3.34e-01	0.071000	6.37e-01
REACTOME RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	90	3.35e-01	0.058800	6.38e-01
REACTOME AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY	8	3.36e-01	-0.197000	6.40e-01
REACTOME VITAMINS	6	3.37e-01	0.226000	6.41e-01
REACTOME PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	26	3.38e-01	-0.109000	6.42e-01
REACTOME GLYCOGEN SYNTHESIS	13	3.39e-01	-0.153000	6.42e-01
REACTOME 2 LTR CIRCLE FORMATION	7	3.40e-01	0.208000	6.42e-01
REACTOME MISCELLANEOUS TRANSPORT AND BINDING EVENTS	24	3.40e-01	-0.113000	6.42e-01
REACTOME RHO GTPASES ACTIVATE ROCKS	19	3.40e-01	0.126000	6.42e-01
REACTOME RHO GTPASE CYCLE	423	3.41e-01	0.027000	6.42e-01
REACTOME INNATE IMMUNE SYSTEM	1002	3.41e-01	0.017800	6.42e-01
REACTOME FGFR2 MUTANT RECEPTOR ACTIVATION	32	3.41e-01	0.097300	6.42e-01
REACTOME SIGNALING BY EGFR IN CANCER	25	3.42e-01	-0.110000	6.42e-01
REACTOME CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	24	3.43e-01	0.112000	6.42e-01
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	3.43e-01	0.092500	6.42e-01
REACTOME SIGNALING BY ERBB2	50	3.44e-01	-0.077400	6.42e-01
REACTOME RELAXIN RECEPTORS	8	3.45e-01	0.193000	6.42e-01
REACTOME LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	3.45e-01	-0.125000	6.42e-01
REACTOME TNF SIGNALING	54	3.45e-01	0.074200	6.42e-01
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	14	3.46e-01	-0.146000	6.42e-01
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	11	3.46e-01	0.164000	6.42e-01
REACTOME CONSTITUTIVE SIGNALING BY EGFRVIII	15	3.46e-01	-0.140000	6.42e-01
REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	3.46e-01	0.116000	6.42e-01
REACTOME SIGNALING BY FGFR2 IIIA TM	19	3.46e-01	0.125000	6.42e-01
REACTOME FORMATION OF APOPTOSOME	10	3.47e-01	0.172000	6.42e-01
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	3.47e-01	0.164000	6.42e-01
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	10	3.47e-01	-0.172000	6.42e-01
REACTOME TRAIL SIGNALING	8	3.47e-01	-0.192000	6.42e-01
REACTOME ROLE OF ABL IN ROBO SLIT SIGNALING	8	3.49e-01	-0.191000	6.45e-01
REACTOME REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	3.49e-01	0.131000	6.45e-01
REACTOME RHOBTB GTPASE CYCLE	34	3.50e-01	0.092600	6.45e-01
REACTOME SENSORY PERCEPTION OF SALTY TASTE	6	3.50e-01	0.220000	6.45e-01
REACTOME RHOU GTPASE CYCLE	37	3.51e-01	0.088700	6.45e-01
REACTOME HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS	9	3.51e-01	0.180000	6.45e-01
REACTOME MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	17	3.51e-01	0.131000	6.45e-01
REACTOME TRANSPORT AND SYNTHESIS OF PAPS	6	3.52e-01	0.219000	6.45e-01
REACTOME REGULATION OF TLR BY ENDOGENOUS LIGAND	21	3.52e-01	-0.117000	6.45e-01
REACTOME NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	3.52e-01	0.162000	6.45e-01
REACTOME PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	21	3.53e-01	0.117000	6.46e-01
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	30	3.54e-01	-0.097900	6.46e-01
REACTOME REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	15	3.54e-01	-0.138000	6.46e-01
REACTOME PTK6 PROMOTES HIF1A STABILIZATION	6	3.55e-01	-0.218000	6.46e-01
REACTOME TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	16	3.55e-01	0.134000	6.46e-01
REACTOME MELANIN BIOSYNTHESIS	5	3.56e-01	-0.239000	6.46e-01
REACTOME FGFR2B LIGAND BINDING AND ACTIVATION	10	3.56e-01	-0.168000	6.47e-01
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	63	3.57e-01	-0.067100	6.48e-01
REACTOME UREA CYCLE	9	3.58e-01	-0.177000	6.50e-01
REACTOME INITIAL TRIGGERING OF COMPLEMENT	21	3.59e-01	-0.116000	6.50e-01
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	15	3.60e-01	0.137000	6.50e-01
REACTOME PENTOSE PHOSPHATE PATHWAY	12	3.61e-01	0.152000	6.51e-01
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	11	3.61e-01	0.159000	6.51e-01
REACTOME ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE	11	3.61e-01	0.159000	6.51e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE	8	3.62e-01	0.186000	6.51e-01
REACTOME RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	19	3.62e-01	-0.121000	6.51e-01
REACTOME MET ACTIVATES PI3K AKT SIGNALING	6	3.63e-01	-0.215000	6.52e-01
REACTOME MATURATION OF PROTEIN 3A	9	3.63e-01	0.175000	6.52e-01
REACTOME SUMO IS PROTEOLYTICALLY PROCESSED	6	3.64e-01	0.214000	6.52e-01
REACTOME B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	84	3.64e-01	0.057300	6.52e-01
REACTOME NEGATIVE REGULATION OF ACTIVITY OF TFAP2 AP 2 FAMILY TRANSCRIPTION FACTORS	10	3.65e-01	0.165000	6.53e-01
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	10	3.66e-01	-0.165000	6.54e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	3.68e-01	0.139000	6.58e-01
REACTOME MOLECULES ASSOCIATED WITH ELASTIC FIBRES	37	3.69e-01	-0.085400	6.58e-01
REACTOME TRYPTOPHAN CATABOLISM	14	3.69e-01	-0.139000	6.58e-01
REACTOME FCGR3A MEDIATED IL10 SYNTHESIS	36	3.70e-01	-0.086300	6.58e-01
REACTOME GLUCOCORTICOID BIOSYNTHESIS	10	3.71e-01	-0.163000	6.58e-01
REACTOME LATE SARS COV 2 INFECTION EVENTS	67	3.71e-01	0.063200	6.58e-01
REACTOME NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	12	3.71e-01	0.149000	6.58e-01
REACTOME FATTY ACIDS	15	3.71e-01	-0.133000	6.58e-01
REACTOME NEGATIVE REGULATION OF FLT3	15	3.72e-01	0.133000	6.58e-01
REACTOME SYNTHESIS OF 16 20 HYDROXYEICOSATETRAENOIC ACIDS HETE	9	3.73e-01	-0.171000	6.58e-01
REACTOME SIGNALING BY VEGF	102	3.73e-01	0.051000	6.58e-01
REACTOME PHENYLALANINE METABOLISM	6	3.74e-01	-0.210000	6.58e-01
REACTOME SUMOYLATION OF DNA METHYLATION PROTEINS	16	3.74e-01	-0.128000	6.58e-01
REACTOME RESOLUTION OF ABASIC SITES AP SITES	38	3.75e-01	0.083200	6.59e-01
REACTOME OPSINS	7	3.76e-01	-0.193000	6.59e-01
REACTOME FGFR3B LIGAND BINDING AND ACTIVATION	7	3.76e-01	-0.193000	6.59e-01
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	14	3.76e-01	0.137000	6.59e-01
REACTOME GLUCAGON TYPE LIGAND RECEPTORS	32	3.77e-01	0.090300	6.59e-01
REACTOME HISTIDINE CATABOLISM	8	3.77e-01	0.180000	6.59e-01
REACTOME POLYMERASE SWITCHING	13	3.79e-01	0.141000	6.62e-01
REACTOME MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	3.80e-01	0.141000	6.63e-01
REACTOME GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	3.80e-01	0.101000	6.63e-01
REACTOME SUMOYLATION OF INTRACELLULAR RECEPTORS	29	3.80e-01	0.094100	6.63e-01
REACTOME PI3K AKT ACTIVATION	9	3.81e-01	-0.169000	6.63e-01
REACTOME SLC TRANSPORTER DISORDERS	94	3.82e-01	0.052200	6.64e-01
REACTOME MULTIFUNCTIONAL ANION EXCHANGERS	9	3.82e-01	-0.168000	6.64e-01
REACTOME PHASE 1 INACTIVATION OF FAST NA CHANNELS	6	3.83e-01	-0.206000	6.65e-01
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	3.84e-01	0.139000	6.66e-01
REACTOME IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	17	3.86e-01	-0.121000	6.68e-01
REACTOME NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	20	3.86e-01	-0.112000	6.68e-01
REACTOME ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	87	3.87e-01	-0.053700	6.68e-01
REACTOME TERMINATION OF TRANSLESION DNA SYNTHESIS	32	3.87e-01	0.088300	6.69e-01
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	66	3.88e-01	0.061500	6.69e-01
REACTOME ACTIVATED NTRK3 SIGNALS THROUGH PI3K	6	3.91e-01	-0.202000	6.74e-01
REACTOME GAP JUNCTION ASSEMBLY	36	3.92e-01	-0.082500	6.74e-01
REACTOME EPHA MEDIATED GROWTH CONE COLLAPSE	29	3.94e-01	-0.091400	6.76e-01
REACTOME TRANSPORT OF SMALL MOLECULES	697	3.94e-01	0.018900	6.76e-01
REACTOME ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	3.94e-01	0.156000	6.76e-01
REACTOME ACTIVATION OF SMO	18	3.95e-01	0.116000	6.76e-01
REACTOME LEISHMANIA INFECTION	156	3.96e-01	0.039400	6.78e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS	9	3.97e-01	-0.163000	6.79e-01
REACTOME AMINO ACID CONJUGATION	9	3.97e-01	-0.163000	6.79e-01
REACTOME TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	52	3.98e-01	0.067700	6.80e-01
REACTOME TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	83	3.99e-01	0.053600	6.80e-01
REACTOME CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	16	3.99e-01	0.122000	6.80e-01
REACTOME MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	15	4.00e-01	0.126000	6.80e-01
REACTOME SIGNALLING TO RAS	20	4.00e-01	-0.109000	6.80e-01
REACTOME SIGNALING BY GPCR	673	4.02e-01	0.019000	6.82e-01
REACTOME INTEGRATION OF ENERGY METABOLISM	105	4.02e-01	-0.047300	6.83e-01
REACTOME GP1B IX V ACTIVATION SIGNALLING	11	4.03e-01	-0.146000	6.83e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY DVL INTERACTING PROTEINS	5	4.03e-01	0.216000	6.83e-01
REACTOME OXIDATIVE STRESS INDUCED SENESCENCE	118	4.08e-01	0.044100	6.90e-01
REACTOME RUNX3 REGULATES P14 ARF	10	4.10e-01	0.151000	6.92e-01
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	28	4.10e-01	0.090000	6.92e-01
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	48	4.11e-01	0.068600	6.92e-01
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	26	4.12e-01	0.093000	6.93e-01
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	12	4.12e-01	0.137000	6.93e-01
REACTOME NEUROTRANSMITTER CLEARANCE	9	4.14e-01	-0.157000	6.96e-01
REACTOME EARLY PHASE OF HIV LIFE CYCLE	14	4.16e-01	0.126000	6.98e-01
REACTOME INTRAFLAGELLAR TRANSPORT	50	4.16e-01	0.066500	6.98e-01
REACTOME DEADENYLATION OF MRNA	25	4.17e-01	0.093800	6.98e-01
REACTOME METALLOTHIONEINS BIND METALS	11	4.17e-01	0.141000	6.99e-01
REACTOME RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES TREGS	9	4.18e-01	-0.156000	6.99e-01
REACTOME ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE	9	4.19e-01	-0.156000	6.99e-01
REACTOME PROSTANOID LIGAND RECEPTORS	9	4.20e-01	-0.155000	7.01e-01
REACTOME EPH EPHRIN MEDIATED REPULSION OF CELLS	50	4.20e-01	0.065900	7.01e-01
REACTOME ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	24	4.25e-01	-0.094100	7.06e-01
REACTOME RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	4.25e-01	0.123000	7.06e-01
REACTOME ORGANIC ANION TRANSPORT	5	4.25e-01	0.206000	7.06e-01
REACTOME NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	15	4.26e-01	-0.119000	7.08e-01
REACTOME PI 3K CASCADE FGFR1	21	4.27e-01	0.100000	7.08e-01
REACTOME NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	24	4.29e-01	0.093200	7.11e-01
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	51	4.30e-01	0.063900	7.11e-01
REACTOME INTERLEUKIN 6 FAMILY SIGNALING	24	4.31e-01	-0.092900	7.13e-01
REACTOME TRIF MEDIATED PROGRAMMED CELL DEATH	9	4.31e-01	0.151000	7.13e-01
REACTOME SYNTHESIS OF UDP N ACETYL GLUCOSAMINE	7	4.32e-01	-0.171000	7.13e-01
REACTOME PECAM1 INTERACTIONS	12	4.32e-01	0.131000	7.13e-01
REACTOME GDP FUCOSE BIOSYNTHESIS	6	4.33e-01	0.185000	7.14e-01
REACTOME MET PROMOTES CELL MOTILITY	41	4.35e-01	-0.070400	7.16e-01
REACTOME SIGNALING BY NTRK2 TRKB	25	4.36e-01	-0.089900	7.16e-01
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	24	4.36e-01	0.091800	7.16e-01
REACTOME STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	4.37e-01	-0.142000	7.16e-01
REACTOME DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B	7	4.39e-01	-0.169000	7.19e-01
REACTOME ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	42	4.40e-01	0.068900	7.20e-01
REACTOME NUCLEOTIDE CATABOLISM	35	4.41e-01	-0.075300	7.21e-01
REACTOME FORMATION OF XYLULOSE 5 PHOSPHATE	5	4.42e-01	-0.199000	7.21e-01
REACTOME OPIOID SIGNALLING	89	4.42e-01	0.047100	7.21e-01
REACTOME DEFECTIVE CHST3 CAUSES SEDCJD	7	4.43e-01	0.167000	7.21e-01
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	4.43e-01	-0.060900	7.21e-01
REACTOME SIGNALING BY EGFR	49	4.43e-01	-0.063300	7.21e-01
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	4.44e-01	0.114000	7.22e-01
REACTOME DIGESTION OF DIETARY LIPID	7	4.45e-01	-0.167000	7.22e-01
REACTOME ACYL CHAIN REMODELING OF CL	5	4.48e-01	0.196000	7.26e-01
REACTOME ALK MUTANTS BIND TKIS	12	4.48e-01	0.126000	7.26e-01
REACTOME FCGR ACTIVATION	11	4.48e-01	-0.132000	7.26e-01
REACTOME CHL1 INTERACTIONS	9	4.49e-01	-0.146000	7.26e-01
REACTOME MEIOTIC RECOMBINATION	80	4.50e-01	0.048800	7.27e-01
REACTOME FREE FATTY ACID RECEPTORS	5	4.51e-01	0.195000	7.27e-01
REACTOME CELLULAR HEXOSE TRANSPORT	21	4.51e-01	0.095000	7.27e-01
REACTOME CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	45	4.51e-01	-0.064900	7.27e-01
REACTOME RHOA GTPASE CYCLE	142	4.52e-01	-0.036600	7.28e-01
REACTOME INACTIVATION OF CSF3 G CSF SIGNALING	25	4.53e-01	0.086800	7.28e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING	5	4.54e-01	-0.193000	7.30e-01
REACTOME STIMULI SENSING CHANNELS	100	4.55e-01	-0.043200	7.31e-01
REACTOME TRANSPORT OF RCBL WITHIN THE BODY	8	4.56e-01	0.152000	7.31e-01
REACTOME VLDL CLEARANCE	6	4.56e-01	0.176000	7.31e-01
REACTOME WNT LIGAND BIOGENESIS AND TRAFFICKING	25	4.58e-01	0.085800	7.32e-01
REACTOME MUCOPOLYSACCHARIDOSES	10	4.62e-01	0.134000	7.39e-01
REACTOME VEGFR2 MEDIATED CELL PROLIFERATION	19	4.62e-01	0.097400	7.39e-01
REACTOME REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	9	4.64e-01	-0.141000	7.39e-01
REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES	507	4.64e-01	0.019000	7.39e-01
REACTOME PI3K AKT SIGNALING IN CANCER	103	4.64e-01	-0.041700	7.39e-01
REACTOME SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	15	4.65e-01	0.109000	7.40e-01
REACTOME RHOBTB1 GTPASE CYCLE	22	4.66e-01	0.089900	7.40e-01
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT	236	4.67e-01	-0.027500	7.41e-01
REACTOME SPHINGOLIPID METABOLISM	84	4.67e-01	0.045900	7.41e-01
REACTOME MUSCLE CONTRACTION	197	4.67e-01	-0.030000	7.41e-01
REACTOME RAC2 GTPASE CYCLE	81	4.68e-01	0.046700	7.41e-01
REACTOME TYPE I HEMIDESMOSOME ASSEMBLY	11	4.69e-01	0.126000	7.42e-01
REACTOME VITAMIN B1 THIAMIN METABOLISM	5	4.70e-01	0.186000	7.43e-01
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	4.71e-01	0.077400	7.43e-01
REACTOME BICARBONATE TRANSPORTERS	10	4.71e-01	0.132000	7.43e-01
REACTOME GRB7 EVENTS IN ERBB2 SIGNALING	5	4.72e-01	-0.186000	7.43e-01
REACTOME ACYL CHAIN REMODELLING OF PE	29	4.72e-01	-0.077100	7.43e-01
REACTOME SIGNALING BY MRAS COMPLEX MUTANTS	7	4.73e-01	0.157000	7.43e-01
REACTOME EPITHELIAL MESENCHYMAL TRANSITION EMT DURING GASTRULATION	7	4.73e-01	0.157000	7.43e-01
REACTOME INTERLEUKIN 37 SIGNALING	20	4.73e-01	0.092700	7.43e-01
REACTOME ERYTHROPOIETIN ACTIVATES STAT5	7	4.75e-01	-0.156000	7.44e-01
REACTOME RHO GTPASES ACTIVATE PKNS	86	4.75e-01	0.044600	7.44e-01
REACTOME P75NTR REGULATES AXONOGENESIS	9	4.75e-01	0.137000	7.44e-01
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	4.76e-01	-0.084000	7.45e-01
REACTOME INTERLEUKIN 35 SIGNALLING	12	4.78e-01	0.118000	7.46e-01
REACTOME REPRODUCTION	136	4.79e-01	0.035100	7.48e-01
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	22	4.79e-01	0.087100	7.48e-01
REACTOME INWARDLY RECTIFYING K CHANNELS	35	4.81e-01	0.068900	7.48e-01
REACTOME PLATELET HOMEOSTASIS	85	4.81e-01	0.044200	7.48e-01
REACTOME ARACHIDONATE PRODUCTION FROM DAG	5	4.82e-01	0.182000	7.49e-01
REACTOME SHC MEDIATED CASCADE FGFR3	17	4.83e-01	-0.098300	7.50e-01
REACTOME HYDROLYSIS OF LPC	9	4.84e-01	0.135000	7.50e-01
REACTOME UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	4.84e-01	0.076400	7.51e-01
REACTOME METHYLATION	14	4.85e-01	0.108000	7.51e-01
REACTOME N GLYCAN TRIMMING AND ELONGATION IN THE CIS GOLGI	5	4.85e-01	0.180000	7.51e-01
REACTOME BETA OXIDATION OF PRISTANOYL COA	9	4.88e-01	-0.134000	7.54e-01
REACTOME CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	4.88e-01	-0.091800	7.54e-01
REACTOME ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	28	4.89e-01	0.075500	7.54e-01
REACTOME SIGNALING BY RNF43 MUTANTS	8	4.90e-01	-0.141000	7.54e-01
REACTOME TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	29	4.90e-01	0.074000	7.54e-01
REACTOME SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	4.91e-01	0.093800	7.54e-01
REACTOME ASSEMBLY OF THE HIV VIRION	16	4.91e-01	0.099300	7.54e-01
REACTOME CLASS A 1 RHODOPSIN LIKE RECEPTORS	312	4.91e-01	0.022600	7.54e-01
REACTOME ION HOMEOSTASIS	52	4.92e-01	-0.055100	7.54e-01
REACTOME PHYSIOLOGICAL FACTORS	14	4.92e-01	0.106000	7.54e-01
REACTOME POTASSIUM CHANNELS	102	4.93e-01	-0.039300	7.55e-01
REACTOME DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	4.93e-01	0.086300	7.55e-01
REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	16	4.94e-01	0.098700	7.55e-01
REACTOME NON INTEGRIN MEMBRANE ECM INTERACTIONS	55	4.95e-01	-0.053200	7.56e-01
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	83	4.98e-01	-0.043100	7.59e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS	12	4.98e-01	-0.113000	7.59e-01
REACTOME ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	4.98e-01	0.124000	7.59e-01
REACTOME IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN	5	5.00e-01	0.174000	7.60e-01
REACTOME INTESTINAL ABSORPTION	5	5.01e-01	-0.174000	7.61e-01
REACTOME DSCAM INTERACTIONS	11	5.01e-01	0.117000	7.61e-01
REACTOME METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS	6	5.02e-01	0.158000	7.61e-01
REACTOME INTERLEUKIN 2 FAMILY SIGNALING	40	5.02e-01	-0.061300	7.61e-01
REACTOME CHOLESTEROL BIOSYNTHESIS	25	5.02e-01	-0.077500	7.61e-01
REACTOME SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	16	5.03e-01	-0.096700	7.61e-01
REACTOME ACYL CHAIN REMODELLING OF PG	18	5.03e-01	-0.091100	7.61e-01
REACTOME CYCLIN D ASSOCIATED EVENTS IN G1	46	5.04e-01	0.056900	7.62e-01
REACTOME RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	5.05e-01	0.071500	7.62e-01
REACTOME RUNX3 REGULATES YAP1 MEDIATED TRANSCRIPTION	8	5.05e-01	0.136000	7.62e-01
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	19	5.06e-01	-0.088000	7.62e-01
REACTOME SYNTHESIS OF LIPOXINS LX	6	5.07e-01	-0.157000	7.62e-01
REACTOME MITOCHONDRIAL UNCOUPLING	5	5.08e-01	0.171000	7.65e-01
REACTOME HUR ELAVL1 BINDS AND STABILIZES MRNA	8	5.09e-01	0.135000	7.65e-01
REACTOME MISMATCH REPAIR	15	5.10e-01	0.098200	7.66e-01
REACTOME INTERLEUKIN RECEPTOR SHC SIGNALING	24	5.11e-01	-0.077500	7.66e-01
REACTOME REGULATION OF INSULIN SECRETION	77	5.11e-01	-0.043300	7.66e-01
REACTOME P2Y RECEPTORS	9	5.13e-01	0.126000	7.68e-01
REACTOME NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER	18	5.14e-01	0.088700	7.69e-01
REACTOME INACTIVATION OF CDC42 AND RAC1	8	5.15e-01	-0.133000	7.69e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH CDK5	6	5.17e-01	-0.153000	7.71e-01
REACTOME VXPX CARGO TARGETING TO CILIUM	20	5.17e-01	0.083700	7.71e-01
REACTOME HYALURONAN BIOSYNTHESIS AND EXPORT	5	5.17e-01	0.167000	7.71e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING	5	5.18e-01	-0.167000	7.71e-01
REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	15	5.19e-01	-0.096100	7.71e-01
REACTOME FATTY ACID METABOLISM	170	5.20e-01	-0.028600	7.71e-01
REACTOME MET ACTIVATES PTPN11	5	5.20e-01	-0.166000	7.71e-01
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	5.20e-01	0.065700	7.71e-01
REACTOME LTC4 CYSLTR MEDIATED IL4 PRODUCTION	6	5.20e-01	-0.151000	7.71e-01
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	14	5.22e-01	-0.098900	7.72e-01
REACTOME COBALAMIN CBL METABOLISM	7	5.22e-01	0.140000	7.72e-01
REACTOME PLASMA LIPOPROTEIN ASSEMBLY	19	5.22e-01	0.084800	7.72e-01
REACTOME INTERLEUKIN 7 SIGNALING	31	5.23e-01	0.066200	7.73e-01
REACTOME TNFR1 INDUCED PROAPOPTOTIC SIGNALING	23	5.24e-01	0.076700	7.74e-01
REACTOME AFLATOXIN ACTIVATION AND DETOXIFICATION	19	5.26e-01	-0.084100	7.74e-01
REACTOME GLYCOGEN STORAGE DISEASES	15	5.26e-01	-0.094600	7.74e-01
REACTOME ACTIVATION OF RAC1	12	5.26e-01	-0.106000	7.74e-01
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	17	5.26e-01	0.088700	7.74e-01
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	15	5.27e-01	0.094300	7.74e-01
REACTOME RHOJ GTPASE CYCLE	51	5.29e-01	-0.051000	7.76e-01
REACTOME SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	5.29e-01	-0.090900	7.76e-01
REACTOME ACTIVATION OF C3 AND C5	6	5.30e-01	-0.148000	7.76e-01
REACTOME UNWINDING OF DNA	12	5.30e-01	0.105000	7.76e-01
REACTOME MINERALOCORTICOID BIOSYNTHESIS	6	5.33e-01	0.147000	7.79e-01
REACTOME VITAMIN B2 RIBOFLAVIN METABOLISM	7	5.34e-01	-0.136000	7.79e-01
REACTOME NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	5.34e-01	0.114000	7.79e-01
REACTOME TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS	5	5.35e-01	0.160000	7.79e-01
REACTOME SYNTHESIS OF DOLICHYL PHOSPHATE	6	5.35e-01	0.146000	7.79e-01
REACTOME MODULATION BY MTB OF HOST IMMUNE SYSTEM	6	5.36e-01	0.146000	7.80e-01
REACTOME SHC RELATED EVENTS TRIGGERED BY IGF1R	9	5.38e-01	-0.119000	7.82e-01
REACTOME NUCLEOTIDE SALVAGE	21	5.39e-01	-0.077500	7.83e-01
REACTOME CRMPS IN SEMA3A SIGNALING	15	5.40e-01	-0.091300	7.84e-01
REACTOME SODIUM COUPLED PHOSPHATE COTRANSPORTERS	5	5.41e-01	0.158000	7.84e-01
REACTOME TIE2 SIGNALING	18	5.41e-01	-0.083200	7.84e-01
REACTOME SIGNALING BY WNT IN CANCER	32	5.42e-01	0.062300	7.84e-01
REACTOME TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION	5	5.43e-01	0.157000	7.84e-01
REACTOME PLATELET AGGREGATION PLUG FORMATION	39	5.43e-01	0.056300	7.84e-01
REACTOME COENZYME A BIOSYNTHESIS	8	5.43e-01	0.124000	7.84e-01
REACTOME REGULATION OF PTEN LOCALIZATION	8	5.44e-01	0.124000	7.84e-01
REACTOME OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS	8	5.45e-01	0.123000	7.86e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	5.46e-01	0.105000	7.86e-01
REACTOME FRS MEDIATED FGFR1 SIGNALING	23	5.46e-01	0.072700	7.86e-01
REACTOME TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	14	5.47e-01	0.092900	7.86e-01
REACTOME MISCELLANEOUS SUBSTRATES	12	5.47e-01	-0.100000	7.86e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES	33	5.49e-01	0.060300	7.87e-01
REACTOME NEGATIVE REGULATION OF MET ACTIVITY	20	5.49e-01	-0.077400	7.87e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	12	5.50e-01	-0.099800	7.87e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	14	5.50e-01	0.092300	7.87e-01
REACTOME EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	5.50e-01	-0.066400	7.87e-01
REACTOME ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	16	5.53e-01	-0.085700	7.87e-01
REACTOME MICRORNA MIRNA BIOGENESIS	25	5.53e-01	0.068500	7.87e-01
REACTOME HEME BIOSYNTHESIS	13	5.54e-01	-0.094800	7.87e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING	6	5.54e-01	0.140000	7.87e-01
REACTOME METABOLISM OF PORPHYRINS	26	5.54e-01	-0.067000	7.87e-01
REACTOME FORMATION OF LATERAL PLATE MESODERM	5	5.54e-01	0.153000	7.87e-01
REACTOME SARS COV 2 TARGETS PDZ PROTEINS IN CELL CELL JUNCTION	5	5.54e-01	0.153000	7.87e-01
REACTOME DOWNREGULATION OF ERBB4 SIGNALING	9	5.55e-01	0.114000	7.87e-01
REACTOME ARMS MEDIATED ACTIVATION	7	5.55e-01	0.129000	7.87e-01
REACTOME SCAVENGING BY CLASS B RECEPTORS	6	5.55e-01	0.139000	7.87e-01
REACTOME PIWI INTERACTING RNA PIRNA BIOGENESIS	29	5.57e-01	0.063000	7.89e-01
REACTOME RNA POLYMERASE I TRANSCRIPTION TERMINATION	30	5.59e-01	0.061600	7.92e-01
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	31	5.61e-01	0.060300	7.93e-01
REACTOME TRNA MODIFICATION IN THE MITOCHONDRION	8	5.62e-01	0.118000	7.94e-01
REACTOME LYSINE CATABOLISM	12	5.63e-01	0.096400	7.94e-01
REACTOME BUDDING AND MATURATION OF HIV VIRION	28	5.64e-01	0.063000	7.94e-01
REACTOME TYROSINE CATABOLISM	5	5.64e-01	-0.149000	7.94e-01
REACTOME SENSING OF DNA DOUBLE STRAND BREAKS	6	5.65e-01	0.136000	7.94e-01
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	5.65e-01	-0.096000	7.94e-01
REACTOME RECYCLING PATHWAY OF L1	43	5.65e-01	0.050700	7.94e-01
REACTOME COMMON PATHWAY OF FIBRIN CLOT FORMATION	21	5.68e-01	-0.071900	7.98e-01
REACTOME CA2 PATHWAY	62	5.68e-01	0.041900	7.98e-01
REACTOME ROS AND RNS PRODUCTION IN PHAGOCYTES	34	5.69e-01	0.056400	7.98e-01
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM	50	5.70e-01	-0.046400	7.98e-01
REACTOME DECTIN 2 FAMILY	26	5.70e-01	-0.064300	7.98e-01
REACTOME TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	10	5.72e-01	0.103000	8.00e-01
REACTOME G2 PHASE	5	5.72e-01	-0.146000	8.00e-01
REACTOME ESTROGEN BIOSYNTHESIS	6	5.73e-01	-0.133000	8.01e-01
REACTOME LAMININ INTERACTIONS	28	5.75e-01	-0.061300	8.01e-01
REACTOME SIGNALING BY FGFR1 IN DISEASE	38	5.75e-01	0.052600	8.01e-01
REACTOME CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	25	5.75e-01	0.064700	8.01e-01
REACTOME O LINKED GLYCOSYLATION OF MUCINS	61	5.75e-01	0.041500	8.01e-01
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE GIP	12	5.77e-01	0.093100	8.02e-01
REACTOME PHASE 0 RAPID DEPOLARISATION	31	5.78e-01	-0.057800	8.02e-01
REACTOME TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	20	5.79e-01	-0.071700	8.02e-01
REACTOME IRAK1 RECRUITS IKK COMPLEX	12	5.80e-01	0.092400	8.02e-01
REACTOME REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	5	5.80e-01	0.143000	8.02e-01
REACTOME REACTIONS SPECIFIC TO THE COMPLEX N GLYCAN SYNTHESIS PATHWAY	10	5.80e-01	0.101000	8.02e-01
REACTOME ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	10	5.80e-01	0.101000	8.02e-01
REACTOME REGULATION OF BACH1 ACTIVITY	11	5.81e-01	0.096100	8.03e-01
REACTOME DNA REPLICATION INITIATION	7	5.82e-01	0.120000	8.03e-01
REACTOME RHOQ GTPASE CYCLE	57	5.83e-01	-0.042100	8.03e-01
REACTOME RUNX3 REGULATES CDKN1A TRANSCRIPTION	7	5.83e-01	0.120000	8.03e-01
REACTOME NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	19	5.84e-01	0.072600	8.03e-01
REACTOME PROPIONYL COA CATABOLISM	5	5.84e-01	-0.141000	8.03e-01
REACTOME SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	52	5.84e-01	0.043900	8.03e-01
REACTOME NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	193	5.85e-01	-0.022800	8.03e-01
REACTOME FGFR1B LIGAND BINDING AND ACTIVATION	6	5.85e-01	0.129000	8.03e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS	7	5.88e-01	0.118000	8.06e-01
REACTOME ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION	10	5.88e-01	0.098800	8.06e-01
REACTOME DEFECTIVE CHST14 CAUSES EDS MUSCULOCONTRACTURAL TYPE	7	5.91e-01	0.117000	8.09e-01
REACTOME ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	9	5.92e-01	0.103000	8.10e-01
REACTOME CATION COUPLED CHLORIDE COTRANSPORTERS	7	5.92e-01	-0.117000	8.10e-01
REACTOME SYNTHESIS OF PE	13	5.93e-01	0.085700	8.10e-01
REACTOME SIGNALING BY MET	78	5.94e-01	-0.034900	8.11e-01
REACTOME P38MAPK EVENTS	13	5.96e-01	0.084900	8.11e-01
REACTOME DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A	5	5.97e-01	0.136000	8.11e-01
REACTOME ARACHIDONIC ACID METABOLISM	57	5.97e-01	-0.040500	8.11e-01
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA PLCG	7	5.98e-01	-0.115000	8.11e-01
REACTOME NEGATIVE REGULATION OF FGFR1 SIGNALING	32	5.98e-01	0.053900	8.11e-01
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	26	5.98e-01	-0.059700	8.11e-01
REACTOME RNA POLYMERASE I PROMOTER ESCAPE	83	5.98e-01	0.033500	8.11e-01
REACTOME SIGNALING BY FGFR2	72	6.00e-01	0.035800	8.11e-01
REACTOME EICOSANOIDS	12	6.00e-01	-0.087500	8.11e-01
REACTOME HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS	7	6.00e-01	0.115000	8.11e-01
REACTOME TACHYKININ RECEPTORS BIND TACHYKININS	5	6.00e-01	0.135000	8.11e-01
REACTOME FGFR2 LIGAND BINDING AND ACTIVATION	19	6.02e-01	-0.069100	8.13e-01
REACTOME DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	17	6.03e-01	0.072800	8.15e-01
REACTOME DISEASES OF CARBOHYDRATE METABOLISM	31	6.04e-01	0.053800	8.15e-01
REACTOME APEX1 INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	7	6.05e-01	0.113000	8.15e-01
REACTOME CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	6.05e-01	-0.090000	8.15e-01
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	20	6.06e-01	0.066500	8.16e-01
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	19	6.07e-01	-0.068200	8.16e-01
REACTOME FCERI MEDIATED CA 2 MOBILIZATION	30	6.08e-01	0.054100	8.17e-01
REACTOME TYSND1 CLEAVES PEROXISOMAL PROTEINS	7	6.09e-01	0.112000	8.17e-01
REACTOME SYNTHESIS OF 5 EICOSATETRAENOIC ACIDS	9	6.09e-01	-0.098300	8.17e-01
REACTOME NEUROTRANSMITTER RELEASE CYCLE	48	6.09e-01	-0.042600	8.17e-01
REACTOME RIPK1 MEDIATED REGULATED NECROSIS	30	6.13e-01	0.053300	8.21e-01
REACTOME PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1	9	6.16e-01	0.096500	8.25e-01
REACTOME TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	6.17e-01	0.068100	8.25e-01
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	7	6.18e-01	-0.109000	8.25e-01
REACTOME MET RECEPTOR RECYCLING	10	6.18e-01	0.091000	8.25e-01
REACTOME ROBO RECEPTORS BIND AKAP5	9	6.20e-01	0.095400	8.26e-01
REACTOME TRANSPORT OF NUCLEOTIDE SUGARS	8	6.20e-01	-0.101000	8.26e-01
REACTOME THE ACTIVATION OF ARYLSULFATASES	8	6.21e-01	0.101000	8.26e-01
REACTOME ACROSOME REACTION AND SPERM OOCYTE MEMBRANE BINDING	6	6.21e-01	-0.117000	8.26e-01
REACTOME DETOXIFICATION OF REACTIVE OXYGEN SPECIES	34	6.22e-01	0.048900	8.26e-01
REACTOME TRANSPORT OF FATTY ACIDS	8	6.23e-01	0.100000	8.26e-01
REACTOME SYNTHESIS OF PA	38	6.23e-01	-0.046100	8.26e-01
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	6.23e-01	-0.036100	8.26e-01
REACTOME SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA PHE	6	6.24e-01	-0.116000	8.26e-01
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	53	6.24e-01	-0.038900	8.26e-01
REACTOME ABACAVIR TRANSMEMBRANE TRANSPORT	5	6.24e-01	-0.126000	8.26e-01
REACTOME REGULATION BY C FLIP	11	6.25e-01	0.085000	8.26e-01
REACTOME FBXW7 MUTANTS AND NOTCH1 IN CANCER	5	6.26e-01	0.126000	8.26e-01
REACTOME PKA ACTIVATION IN GLUCAGON SIGNALLING	17	6.27e-01	-0.068200	8.27e-01
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	15	6.28e-01	0.072300	8.28e-01
REACTOME FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	6.29e-01	-0.088100	8.29e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE	5	6.30e-01	-0.124000	8.29e-01
REACTOME RHO GTPASES ACTIVATE KTN1	11	6.30e-01	0.083800	8.29e-01
REACTOME REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	53	6.32e-01	0.038000	8.31e-01
REACTOME LECTIN PATHWAY OF COMPLEMENT ACTIVATION	8	6.33e-01	-0.097600	8.31e-01
REACTOME NICOTINAMIDE SALVAGING	19	6.33e-01	0.063300	8.31e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	24	6.35e-01	0.056000	8.33e-01
REACTOME RHOG GTPASE CYCLE	71	6.36e-01	-0.032500	8.33e-01
REACTOME COPII MEDIATED VESICLE TRANSPORT	66	6.37e-01	0.033600	8.35e-01
REACTOME HIV TRANSCRIPTION INITIATION	43	6.39e-01	0.041300	8.36e-01
REACTOME NADE MODULATES DEATH SIGNALLING	5	6.42e-01	0.120000	8.39e-01
REACTOME PRE NOTCH PROCESSING IN GOLGI	18	6.43e-01	-0.063200	8.39e-01
REACTOME SIGNALING BY CSF1 M CSF IN MYELOID CELLS	30	6.46e-01	0.048500	8.43e-01
REACTOME CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	25	6.47e-01	-0.052900	8.44e-01
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	6.49e-01	0.058800	8.45e-01
REACTOME CREATION OF C4 AND C2 ACTIVATORS	14	6.49e-01	-0.070200	8.45e-01
REACTOME ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	59	6.50e-01	-0.034200	8.45e-01
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	55	6.50e-01	0.035300	8.45e-01
REACTOME SIGNALING BY FGFR4 IN DISEASE	11	6.53e-01	0.078300	8.48e-01
REACTOME SIGNALING BY SCF KIT	42	6.53e-01	0.040100	8.48e-01
REACTOME DEFECTIVE GALNT3 CAUSES HFTC	16	6.53e-01	0.064800	8.48e-01
REACTOME NR1H2 NR1H3 REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE	5	6.55e-01	0.115000	8.49e-01
REACTOME FATTY ACYL COA BIOSYNTHESIS	36	6.56e-01	-0.042900	8.50e-01
REACTOME RAC3 GTPASE CYCLE	85	6.58e-01	0.027800	8.51e-01
REACTOME MYOGENESIS	29	6.58e-01	0.047500	8.51e-01
REACTOME NECTIN NECL TRANS HETERODIMERIZATION	7	6.58e-01	0.096500	8.51e-01
REACTOME FLT3 SIGNALING BY CBL MUTANTS	7	6.61e-01	0.095600	8.53e-01
REACTOME NFE2L2 REGULATING ANTI OXIDANT DETOXIFICATION ENZYMES	17	6.61e-01	0.061300	8.53e-01
REACTOME CHYLOMICRON ASSEMBLY	10	6.62e-01	-0.079900	8.53e-01
REACTOME ACYL CHAIN REMODELING OF DAG AND TAG	5	6.63e-01	0.113000	8.53e-01
REACTOME ATTACHMENT OF GPI ANCHOR TO UPAR	7	6.63e-01	-0.095000	8.53e-01
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	23	6.64e-01	0.052400	8.53e-01
REACTOME INTERLEUKIN 21 SIGNALING	9	6.66e-01	0.083100	8.55e-01
REACTOME G PROTEIN MEDIATED EVENTS	53	6.66e-01	-0.034300	8.55e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	6.70e-01	0.046500	8.59e-01
REACTOME INOSITOL PHOSPHATE METABOLISM	45	6.70e-01	0.036700	8.59e-01
REACTOME PYROPTOSIS	27	6.72e-01	-0.047000	8.61e-01
REACTOME METAL ION SLC TRANSPORTERS	23	6.74e-01	0.050700	8.62e-01
REACTOME SENSORY PERCEPTION OF TASTE	47	6.76e-01	-0.035300	8.64e-01
REACTOME ION CHANNEL TRANSPORT	172	6.79e-01	-0.018300	8.67e-01
REACTOME REGULATION OF LIPID METABOLISM BY PPARALPHA	115	6.79e-01	0.022300	8.67e-01
REACTOME SIGNALING BY PDGFR IN DISEASE	20	6.80e-01	0.053300	8.67e-01
REACTOME MATURATION OF SARS COV 1 SPIKE PROTEIN	5	6.81e-01	0.106000	8.68e-01
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	122	6.82e-01	-0.021500	8.68e-01
REACTOME SIGNALING BY CSF3 G CSF	30	6.82e-01	0.043200	8.69e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	21	6.83e-01	0.051400	8.69e-01
REACTOME SIGNALING BY HIPPO	19	6.88e-01	-0.053200	8.74e-01
REACTOME KINESINS	59	6.88e-01	-0.030200	8.74e-01
REACTOME DAG AND IP3 SIGNALING	40	6.90e-01	-0.036400	8.76e-01
REACTOME COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	32	6.91e-01	0.040600	8.76e-01
REACTOME RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS	7	6.91e-01	-0.086700	8.76e-01
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	6.92e-01	0.057100	8.77e-01
REACTOME INTERLEUKIN 10 SIGNALING	43	6.93e-01	-0.034800	8.77e-01
REACTOME FLT3 SIGNALING THROUGH SRC FAMILY KINASES	6	6.95e-01	-0.092600	8.77e-01
REACTOME INTERLEUKIN 20 FAMILY SIGNALING	25	6.95e-01	-0.045400	8.77e-01
REACTOME NUCLEAR SIGNALING BY ERBB4	32	6.95e-01	0.040000	8.78e-01
REACTOME NEF AND SIGNAL TRANSDUCTION	8	6.96e-01	0.079800	8.78e-01
REACTOME ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	11	6.97e-01	0.067900	8.78e-01
REACTOME CONDENSATION OF PROPHASE CHROMOSOMES	66	6.98e-01	0.027600	8.79e-01
REACTOME NPAS4 REGULATES EXPRESSION OF TARGET GENES	21	7.00e-01	0.048600	8.79e-01
REACTOME GLUTATHIONE SYNTHESIS AND RECYCLING	12	7.00e-01	-0.064200	8.79e-01
REACTOME PLASMA LIPOPROTEIN REMODELING	33	7.00e-01	0.038800	8.79e-01
REACTOME INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	45	7.01e-01	-0.033100	8.79e-01
REACTOME REPRESSION OF WNT TARGET GENES	14	7.01e-01	0.059200	8.79e-01
REACTOME TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	7.02e-01	0.063900	8.79e-01
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	129	7.02e-01	-0.019500	8.80e-01
REACTOME DAP12 INTERACTIONS	37	7.05e-01	-0.036000	8.82e-01
REACTOME ACYL CHAIN REMODELLING OF PC	27	7.05e-01	0.042100	8.82e-01
REACTOME FGFR1 MUTANT RECEPTOR ACTIVATION	31	7.07e-01	0.039000	8.82e-01
REACTOME EGFR TRANSACTIVATION BY GASTRIN	9	7.08e-01	-0.072200	8.82e-01
REACTOME SARS COV 1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES	39	7.08e-01	0.034600	8.82e-01
REACTOME SENSORY PROCESSING OF SOUND	72	7.08e-01	0.025500	8.82e-01
REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	20	7.08e-01	-0.048300	8.82e-01
REACTOME RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	7.09e-01	0.035400	8.83e-01
REACTOME CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	63	7.11e-01	0.027000	8.84e-01
REACTOME DOWNREGULATION OF ERBB2 SIGNALING	29	7.12e-01	-0.039500	8.85e-01
REACTOME GABA B RECEPTOR ACTIVATION	43	7.14e-01	0.032300	8.85e-01
REACTOME ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	12	7.14e-01	0.061100	8.85e-01
REACTOME FLT3 SIGNALING IN DISEASE	28	7.15e-01	0.039900	8.85e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	11	7.15e-01	0.063600	8.85e-01
REACTOME ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS	7	7.15e-01	-0.079700	8.85e-01
REACTOME HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR IN THE PRESENCE OF LIGAND	55	7.16e-01	-0.028300	8.86e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION	41	7.17e-01	0.032700	8.87e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	24	7.18e-01	-0.042600	8.87e-01
REACTOME LINOLEIC ACID LA METABOLISM	7	7.19e-01	0.078600	8.87e-01
REACTOME CIRCADIAN CLOCK	68	7.19e-01	0.025200	8.87e-01
REACTOME INTERLEUKIN 1 PROCESSING	9	7.19e-01	-0.069200	8.87e-01
REACTOME RAC1 GTPASE CYCLE	172	7.20e-01	0.015800	8.87e-01
REACTOME DAP12 SIGNALING	27	7.21e-01	0.039700	8.88e-01
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	24	7.22e-01	0.041900	8.88e-01
REACTOME ION TRANSPORT BY P TYPE ATPASES	51	7.23e-01	-0.028700	8.88e-01
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	30	7.23e-01	0.037300	8.88e-01
REACTOME OVARIAN TUMOR DOMAIN PROTEASES	36	7.24e-01	0.034000	8.88e-01
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	23	7.25e-01	0.042400	8.88e-01
REACTOME SIGNALING BY MEMBRANE TETHERED FUSIONS OF PDGFRA OR PDGFRB	5	7.26e-01	0.090600	8.88e-01
REACTOME VASOPRESSIN LIKE RECEPTORS	5	7.26e-01	0.090500	8.88e-01
REACTOME TRANSPORT OF ORGANIC ANIONS	10	7.26e-01	-0.064000	8.88e-01
REACTOME GPER1 SIGNALING	45	7.26e-01	0.030200	8.88e-01
REACTOME METABOLISM OF FAT SOLUBLE VITAMINS	46	7.27e-01	-0.029800	8.88e-01
REACTOME BETA OXIDATION OF HEXANOYL COA TO BUTANOYL COA	5	7.28e-01	-0.089800	8.89e-01
REACTOME TERMINAL PATHWAY OF COMPLEMENT	8	7.29e-01	-0.070800	8.89e-01
REACTOME REGULATION OF NPAS4 GENE TRANSCRIPTION	5	7.30e-01	0.089300	8.89e-01
REACTOME CHREBP ACTIVATES METABOLIC GENE EXPRESSION	8	7.30e-01	-0.070500	8.89e-01
REACTOME PI 3K CASCADE FGFR2	22	7.30e-01	0.042500	8.89e-01
REACTOME FATTY ACIDS BOUND TO GPR40 FFAR1 REGULATE INSULIN SECRETION	8	7.32e-01	-0.069800	8.89e-01
REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	7.33e-01	-0.047800	8.89e-01
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	160	7.33e-01	-0.015600	8.89e-01
REACTOME JOSEPHIN DOMAIN DUBS	11	7.33e-01	0.059300	8.89e-01
REACTOME DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	38	7.34e-01	-0.031900	8.89e-01
REACTOME CDC42 GTPASE CYCLE	144	7.34e-01	-0.016400	8.89e-01
REACTOME METABOLISM OF AMINE DERIVED HORMONES	17	7.37e-01	-0.047100	8.92e-01
REACTOME REGULATION OF KIT SIGNALING	16	7.38e-01	0.048400	8.92e-01
REACTOME RUNX2 REGULATES BONE DEVELOPMENT	29	7.38e-01	0.035900	8.92e-01
REACTOME RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	27	7.39e-01	0.037000	8.93e-01
REACTOME ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	7.40e-01	0.055400	8.93e-01
REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	16	7.40e-01	0.047900	8.93e-01
REACTOME UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	7.41e-01	0.057600	8.93e-01
REACTOME SIGNAL ATTENUATION	10	7.42e-01	-0.060200	8.93e-01
REACTOME MAPK1 ERK2 ACTIVATION	9	7.42e-01	-0.063500	8.93e-01
REACTOME ACYL CHAIN REMODELLING OF PI	17	7.43e-01	0.045900	8.94e-01
REACTOME ESTROGEN STIMULATED SIGNALING THROUGH PRKCZ	6	7.43e-01	0.077200	8.94e-01
REACTOME ANCHORING FIBRIL FORMATION	13	7.46e-01	0.051900	8.96e-01
REACTOME SIGNALING BY FGFR3	39	7.46e-01	-0.029900	8.96e-01
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	18	7.47e-01	0.044000	8.96e-01
REACTOME SYNTHESIS OF PI	5	7.48e-01	0.082900	8.97e-01
REACTOME DNA DAMAGE REVERSAL	8	7.49e-01	-0.065300	8.97e-01
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	7.50e-01	0.036100	8.97e-01
REACTOME ACTIVATION OF TRKA RECEPTORS	6	7.51e-01	-0.074900	8.97e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	7.51e-01	0.034700	8.97e-01
REACTOME SIGNALING BY PTK6	54	7.52e-01	-0.024900	8.97e-01
REACTOME AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	9	7.52e-01	-0.060800	8.97e-01
REACTOME PI 3K CASCADE FGFR4	19	7.53e-01	0.041600	8.98e-01
REACTOME SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	60	7.58e-01	0.023000	9.03e-01
REACTOME SIGNALING BY FGFR	85	7.58e-01	0.019300	9.03e-01
REACTOME THYROXINE BIOSYNTHESIS	10	7.61e-01	-0.055600	9.05e-01
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	7.62e-01	0.055400	9.06e-01
REACTOME PTK6 REGULATES CELL CYCLE	6	7.63e-01	-0.071100	9.07e-01
REACTOME POU5F1 OCT4 SOX2 NANOG REPRESS GENES RELATED TO DIFFERENTIATION	10	7.65e-01	0.054700	9.08e-01
REACTOME GPCR LIGAND BINDING	444	7.66e-01	0.008250	9.08e-01
REACTOME RESPONSE TO METAL IONS	14	7.67e-01	0.045800	9.08e-01
REACTOME GLYCEROPHOSPHOLIPID CATABOLISM	7	7.67e-01	-0.064700	9.08e-01
REACTOME RSK ACTIVATION	5	7.67e-01	0.076400	9.08e-01
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	29	7.68e-01	-0.031600	9.08e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	13	7.69e-01	-0.047100	9.08e-01
REACTOME ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS	5	7.69e-01	-0.075800	9.08e-01
REACTOME ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	28	7.69e-01	-0.032000	9.08e-01
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	7.70e-01	0.043600	9.08e-01
REACTOME VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	7.71e-01	0.033000	9.09e-01
REACTOME SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	31	7.71e-01	-0.030100	9.09e-01
REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	7.73e-01	-0.038100	9.10e-01
REACTOME G ALPHA Z SIGNALLING EVENTS	48	7.75e-01	0.023900	9.11e-01
REACTOME LYSOSPHINGOLIPID AND LPA RECEPTORS	14	7.78e-01	0.043600	9.14e-01
REACTOME SIGNALLING TO ERKS	34	7.80e-01	0.027700	9.16e-01
REACTOME NETRIN 1 SIGNALING	49	7.83e-01	0.022800	9.17e-01
REACTOME TIGHT JUNCTION INTERACTIONS	29	7.83e-01	0.029500	9.17e-01
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	16	7.84e-01	0.039500	9.17e-01
REACTOME PP2A MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS	6	7.84e-01	0.064500	9.17e-01
REACTOME FRS MEDIATED FGFR3 SIGNALING	19	7.85e-01	-0.036200	9.17e-01
REACTOME METABOLISM OF STEROIDS	150	7.85e-01	-0.012900	9.17e-01
REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	17	7.86e-01	0.038100	9.17e-01
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	14	7.86e-01	-0.041900	9.17e-01
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	19	7.86e-01	0.035900	9.17e-01
REACTOME FGFR3 LIGAND BINDING AND ACTIVATION	12	7.87e-01	-0.045100	9.17e-01
REACTOME LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX	5	7.87e-01	0.069900	9.17e-01
REACTOME PASSIVE TRANSPORT BY AQUAPORINS	13	7.87e-01	0.043300	9.17e-01
REACTOME NRCAM INTERACTIONS	6	7.88e-01	-0.063300	9.17e-01
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	9	7.88e-01	-0.051700	9.17e-01
REACTOME SYNDECAN INTERACTIONS	26	7.89e-01	-0.030300	9.17e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION OF UNSATURATED FATTY ACIDS	6	7.90e-01	0.062900	9.17e-01
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	69	7.92e-01	0.018400	9.17e-01
REACTOME PHASE 2 PLATEAU PHASE	14	7.92e-01	-0.040800	9.17e-01
REACTOME CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	7.92e-01	0.048100	9.17e-01
REACTOME STRIATED MUSCLE CONTRACTION	35	7.93e-01	0.025700	9.17e-01
REACTOME CIPROFLOXACIN ADME	5	7.93e-01	-0.067700	9.17e-01
REACTOME DISEASES ASSOCIATED WITH SURFACTANT METABOLISM	9	7.93e-01	-0.050400	9.17e-01
REACTOME DISEASES OF DNA REPAIR	51	7.93e-01	0.021200	9.17e-01
REACTOME RAS SIGNALING DOWNSTREAM OF NF1 LOSS OF FUNCTION VARIANTS	7	7.94e-01	-0.057000	9.17e-01
REACTOME SHC MEDIATED CASCADE FGFR1	21	7.95e-01	0.032800	9.17e-01
REACTOME SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	7.96e-01	-0.029900	9.18e-01
REACTOME RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	52	7.98e-01	0.020500	9.18e-01
REACTOME TLR3 MEDIATED TICAM1 DEPENDENT PROGRAMMED CELL DEATH	6	7.98e-01	0.060300	9.18e-01
REACTOME BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	10	7.99e-01	0.046600	9.18e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	31	7.99e-01	0.026400	9.18e-01
REACTOME SIGNALING BY LRP5 MUTANTS	6	8.00e-01	0.059900	9.18e-01
REACTOME DRUG MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY	5	8.00e-01	-0.065500	9.18e-01
REACTOME PRE NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM	6	8.01e-01	0.059500	9.18e-01
REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV 1 INFECTION	5	8.01e-01	0.065000	9.18e-01
REACTOME HEME SIGNALING	47	8.04e-01	0.021000	9.18e-01
REACTOME SHC MEDIATED CASCADE FGFR4	19	8.04e-01	-0.032900	9.18e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	17	8.04e-01	0.034800	9.18e-01
REACTOME BETA OXIDATION OF DECANOYL COA TO OCTANOYL COA COA	6	8.04e-01	-0.058400	9.18e-01
REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	24	8.04e-01	-0.029200	9.18e-01
REACTOME VLDL ASSEMBLY	5	8.04e-01	0.064000	9.18e-01
REACTOME REDUCTION OF CYTOSOLIC CA LEVELS	11	8.05e-01	0.043000	9.18e-01
REACTOME TRIGLYCERIDE BIOSYNTHESIS	12	8.07e-01	0.040700	9.20e-01
REACTOME PURINE CATABOLISM	17	8.08e-01	0.034100	9.20e-01
REACTOME CD163 MEDIATING AN ANTI INFLAMMATORY RESPONSE	9	8.08e-01	-0.046800	9.20e-01
REACTOME BETA OXIDATION OF OCTANOYL COA TO HEXANOYL COA	5	8.10e-01	0.062000	9.20e-01
REACTOME G ALPHA I SIGNALLING EVENTS	304	8.11e-01	0.007990	9.20e-01
REACTOME INTERLEUKIN 17 SIGNALING	66	8.11e-01	0.017000	9.20e-01
REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	36	8.11e-01	-0.023000	9.20e-01
REACTOME SUPPRESSION OF APOPTOSIS	7	8.11e-01	-0.052100	9.20e-01
REACTOME CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	25	8.11e-01	0.027600	9.20e-01
REACTOME LDL REMODELING	6	8.13e-01	-0.055900	9.20e-01
REACTOME RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	22	8.13e-01	0.029200	9.20e-01
REACTOME SEMAPHORIN INTERACTIONS	61	8.15e-01	-0.017300	9.22e-01
REACTOME RELEASE OF HH NP FROM THE SECRETING CELL	8	8.16e-01	0.047600	9.22e-01
REACTOME ATTENUATION PHASE	27	8.16e-01	-0.025900	9.22e-01
REACTOME CROSSLINKING OF COLLAGEN FIBRILS	16	8.17e-01	-0.033500	9.22e-01
REACTOME CRISTAE FORMATION	27	8.18e-01	0.025600	9.22e-01
REACTOME WNT MEDIATED ACTIVATION OF DVL	8	8.19e-01	0.046800	9.22e-01
REACTOME NEUTROPHIL DEGRANULATION	460	8.19e-01	-0.006230	9.22e-01
REACTOME LIPOPHAGY	9	8.20e-01	0.043900	9.22e-01
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27 HYDROXYCHOLESTEROL	15	8.20e-01	0.034000	9.22e-01
REACTOME HORMONE LIGAND BINDING RECEPTORS	12	8.29e-01	-0.036100	9.31e-01
REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	9	8.29e-01	0.041700	9.31e-01
REACTOME SIGNAL TRANSDUCTION BY L1	20	8.29e-01	-0.027900	9.31e-01
REACTOME DNA METHYLATION	58	8.31e-01	-0.016200	9.33e-01
REACTOME ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	8.33e-01	0.029600	9.34e-01
REACTOME CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	100	8.34e-01	-0.012100	9.34e-01
REACTOME CARNITINE METABOLISM	13	8.35e-01	0.033500	9.34e-01
REACTOME NEGATIVE REGULATION OF FGFR3 SIGNALING	28	8.35e-01	-0.022700	9.34e-01
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	17	8.35e-01	0.029100	9.34e-01
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE FGFR4	14	8.36e-01	0.031900	9.34e-01
REACTOME SODIUM CALCIUM EXCHANGERS	11	8.36e-01	-0.036000	9.34e-01
REACTOME SIGNALING BY NTRK3 TRKC	17	8.36e-01	-0.028900	9.34e-01
REACTOME MAPK3 ERK1 ACTIVATION	10	8.37e-01	0.037500	9.34e-01
REACTOME DEFECTIVE C1GALT1C1 CAUSES TNPS	16	8.40e-01	0.029100	9.36e-01
REACTOME NGF INDEPENDANT TRKA ACTIVATION	5	8.41e-01	0.051900	9.36e-01
REACTOME RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	8.41e-01	-0.024100	9.36e-01
REACTOME RHO GTPASES ACTIVATE IQGAPS	31	8.42e-01	-0.020700	9.36e-01
REACTOME GLYCOSPHINGOLIPID METABOLISM	39	8.42e-01	-0.018400	9.36e-01
REACTOME METABOLISM OF INGESTED SEMET SEC MESEC INTO H2SE	7	8.42e-01	0.043400	9.36e-01
REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	26	8.44e-01	0.022200	9.37e-01
REACTOME BASE EXCISION REPAIR AP SITE FORMATION	59	8.45e-01	-0.014700	9.37e-01
REACTOME METABOLISM OF NUCLEOTIDES	94	8.46e-01	-0.011600	9.38e-01
REACTOME INTERLEUKIN 6 SIGNALING	11	8.47e-01	-0.033700	9.38e-01
REACTOME RET SIGNALING	40	8.49e-01	-0.017500	9.39e-01
REACTOME CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	9	8.49e-01	-0.036700	9.39e-01
REACTOME LIGAND RECEPTOR INTERACTIONS	8	8.50e-01	-0.038700	9.39e-01
REACTOME SIGNALING BY KIT IN DISEASE	20	8.50e-01	0.024400	9.39e-01
REACTOME RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS	9	8.51e-01	-0.036100	9.40e-01
REACTOME KILLING MECHANISMS	11	8.52e-01	0.032400	9.40e-01
REACTOME L1CAM INTERACTIONS	112	8.53e-01	-0.010200	9.40e-01
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	35	8.53e-01	0.018200	9.40e-01
REACTOME METABOLISM OF CARBOHYDRATES	279	8.54e-01	0.006410	9.40e-01
REACTOME RUNX2 REGULATES CHONDROCYTE MATURATION	5	8.54e-01	-0.047400	9.40e-01
REACTOME SIGNALING BY LEPTIN	11	8.58e-01	0.031300	9.42e-01
REACTOME PYRUVATE METABOLISM	29	8.58e-01	0.019100	9.42e-01
REACTOME TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	36	8.59e-01	0.017200	9.42e-01
REACTOME FRS MEDIATED FGFR2 SIGNALING	24	8.59e-01	0.020900	9.42e-01
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	122	8.60e-01	0.009250	9.42e-01
REACTOME GAP JUNCTION TRAFFICKING AND REGULATION	49	8.60e-01	0.014500	9.42e-01
REACTOME METHIONINE SALVAGE PATHWAY	6	8.60e-01	0.041500	9.42e-01
REACTOME HSF1 ACTIVATION	29	8.64e-01	0.018400	9.45e-01
REACTOME METABOLISM OF FOLATE AND PTERINES	17	8.64e-01	-0.023900	9.45e-01
REACTOME ORGANIC ANION TRANSPORTERS	10	8.65e-01	0.031100	9.45e-01
REACTOME G ALPHA S SIGNALLING EVENTS	155	8.65e-01	-0.007940	9.45e-01
REACTOME NEGATIVE REGULATION OF FGFR2 SIGNALING	33	8.68e-01	0.016800	9.47e-01
REACTOME TRP CHANNELS	27	8.68e-01	-0.018500	9.47e-01
REACTOME GLYCOGEN METABOLISM	22	8.69e-01	0.020300	9.48e-01
REACTOME ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	41	8.70e-01	0.014800	9.48e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH RAS	9	8.70e-01	-0.031400	9.48e-01
REACTOME TRAFFICKING OF AMPA RECEPTORS	29	8.72e-01	-0.017300	9.49e-01
REACTOME UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN	6	8.73e-01	-0.037800	9.49e-01
REACTOME HEME DEGRADATION	15	8.74e-01	-0.023700	9.50e-01
REACTOME IRS ACTIVATION	5	8.75e-01	-0.040800	9.50e-01
REACTOME GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	42	8.76e-01	0.013900	9.51e-01
REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	23	8.78e-01	0.018600	9.52e-01
REACTOME DERMATAN SULFATE BIOSYNTHESIS	10	8.79e-01	-0.027800	9.52e-01
REACTOME OTHER INTERLEUKIN SIGNALING	24	8.79e-01	0.017900	9.52e-01
REACTOME DISEASES OF MISMATCH REPAIR MMR	5	8.81e-01	-0.038700	9.52e-01
REACTOME DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	15	8.81e-01	0.022300	9.52e-01
REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	111	8.82e-01	0.008180	9.52e-01
REACTOME GABA RECEPTOR ACTIVATION	57	8.83e-01	-0.011300	9.52e-01
REACTOME CITRIC ACID CYCLE TCA CYCLE	21	8.83e-01	-0.018500	9.52e-01
REACTOME METALLOPROTEASE DUBS	36	8.84e-01	0.014100	9.52e-01
REACTOME HSF1 DEPENDENT TRANSACTIVATION	37	8.84e-01	-0.013900	9.52e-01
REACTOME HS GAG DEGRADATION	19	8.84e-01	-0.019400	9.52e-01
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	101	8.84e-01	-0.008380	9.52e-01
REACTOME SIGNALING BY FGFR4	40	8.86e-01	-0.013100	9.53e-01
REACTOME ASPARTATE AND ASPARAGINE METABOLISM	11	8.87e-01	-0.024800	9.53e-01
REACTOME CROSS PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS PHAGOSOMES	6	8.87e-01	0.033500	9.53e-01
REACTOME SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	8.87e-01	0.023600	9.53e-01
REACTOME PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	14	8.89e-01	-0.021500	9.54e-01
REACTOME COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	52	8.89e-01	-0.011200	9.54e-01
REACTOME BILE ACID AND BILE SALT METABOLISM	45	8.92e-01	0.011700	9.56e-01
REACTOME FRS MEDIATED FGFR4 SIGNALING	21	8.93e-01	0.017000	9.56e-01
REACTOME SOS MEDIATED SIGNALLING	7	8.93e-01	-0.029300	9.56e-01
REACTOME RND3 GTPASE CYCLE	41	8.96e-01	-0.011800	9.58e-01
REACTOME SPRY REGULATION OF FGF SIGNALING	16	8.97e-01	-0.018800	9.58e-01
REACTOME NEGATIVE REGULATION OF FGFR4 SIGNALING	30	8.97e-01	0.013700	9.58e-01
REACTOME ARYL HYDROCARBON RECEPTOR SIGNALLING	6	8.98e-01	-0.030100	9.58e-01
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	32	8.99e-01	0.013000	9.58e-01
REACTOME EARLY SARS COV 2 INFECTION EVENTS	34	8.99e-01	0.012600	9.58e-01
REACTOME MET ACTIVATES RAP1 AND RAC1	11	9.00e-01	0.021900	9.59e-01
REACTOME CHYLOMICRON CLEARANCE	5	9.01e-01	0.032200	9.59e-01
REACTOME ALPHA OXIDATION OF PHYTANATE	6	9.02e-01	0.029000	9.60e-01
REACTOME TNFR1 MEDIATED CERAMIDE PRODUCTION	6	9.04e-01	0.028500	9.61e-01
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	13	9.05e-01	0.019100	9.61e-01
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	93	9.05e-01	0.007150	9.61e-01
REACTOME IRON UPTAKE AND TRANSPORT	56	9.06e-01	-0.009130	9.61e-01
REACTOME AGGREPHAGY	42	9.06e-01	-0.010500	9.61e-01
REACTOME MYOCLONIC EPILEPSY OF LAFORA	9	9.08e-01	-0.022400	9.61e-01
REACTOME LATE ENDOSOMAL MICROAUTOPHAGY	33	9.08e-01	0.011700	9.61e-01
REACTOME INTERLEUKIN 2 SIGNALING	11	9.08e-01	-0.020100	9.62e-01
REACTOME GLYCOSAMINOGLYCAN METABOLISM	118	9.09e-01	-0.006080	9.62e-01
REACTOME ERYTHROPOIETIN ACTIVATES RAS	14	9.11e-01	-0.017300	9.62e-01
REACTOME ENOS ACTIVATION	11	9.11e-01	0.019500	9.62e-01
REACTOME SMOOTH MUSCLE CONTRACTION	43	9.11e-01	0.009820	9.62e-01
REACTOME FGFRL1 MODULATION OF FGFR1 SIGNALING	13	9.12e-01	-0.017700	9.62e-01
REACTOME EPHRIN SIGNALING	17	9.13e-01	0.015400	9.62e-01
REACTOME INTERLEUKIN 36 PATHWAY	7	9.14e-01	0.023600	9.63e-01
REACTOME RHOBTB3 ATPASE CYCLE	8	9.14e-01	-0.021900	9.63e-01
REACTOME PI 3K CASCADE FGFR3	17	9.15e-01	-0.015000	9.63e-01
REACTOME SIGNALING BY FGFR1	49	9.19e-01	-0.008360	9.67e-01
REACTOME VITAMIN C ASCORBATE METABOLISM	8	9.21e-01	0.020300	9.68e-01
REACTOME THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	23	9.22e-01	-0.011800	9.68e-01
REACTOME EICOSANOID LIGAND BINDING RECEPTORS	14	9.22e-01	0.015100	9.68e-01
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	14	9.23e-01	0.015000	9.68e-01
REACTOME DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	19	9.25e-01	0.012400	9.70e-01
REACTOME G ALPHA 12 13 SIGNALLING EVENTS	74	9.28e-01	-0.006030	9.71e-01
REACTOME TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	26	9.29e-01	0.010100	9.71e-01
REACTOME PHASE 3 RAPID REPOLARISATION	8	9.29e-01	-0.018200	9.71e-01
REACTOME SPERM MOTILITY AND TAXES	9	9.29e-01	-0.017200	9.71e-01
REACTOME INTERLEUKIN 15 SIGNALING	13	9.29e-01	0.014300	9.71e-01
REACTOME FGFR1C LIGAND BINDING AND ACTIVATION	11	9.30e-01	0.015300	9.72e-01
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	9.31e-01	-0.005720	9.72e-01
REACTOME PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS	8	9.32e-01	-0.017400	9.72e-01
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	51	9.32e-01	0.006910	9.72e-01
REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	30	9.33e-01	0.008830	9.72e-01
REACTOME IRAK4 DEFICIENCY TLR2 4	17	9.36e-01	-0.011200	9.75e-01
REACTOME CREB PHOSPHORYLATION	6	9.40e-01	-0.017900	9.77e-01
REACTOME REGULATED NECROSIS	57	9.40e-01	0.005780	9.77e-01
REACTOME INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	103	9.41e-01	-0.004220	9.77e-01
REACTOME SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	9.41e-01	0.011800	9.77e-01
REACTOME VISUAL PHOTOTRANSDUCTION	93	9.41e-01	0.004410	9.77e-01
REACTOME PRC2 METHYLATES HISTONES AND DNA	65	9.43e-01	0.005150	9.78e-01
REACTOME REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS	7	9.44e-01	0.015400	9.78e-01
REACTOME NOD1 2 SIGNALING PATHWAY	33	9.45e-01	0.006970	9.78e-01
REACTOME INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	28	9.46e-01	-0.007400	9.78e-01
REACTOME PTK6 EXPRESSION	5	9.47e-01	-0.017300	9.78e-01
REACTOME BIOSYNTHESIS OF EPA DERIVED SPMS	6	9.47e-01	0.015700	9.78e-01
REACTOME FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE	5	9.47e-01	-0.017000	9.78e-01
REACTOME CHAPERONE MEDIATED AUTOPHAGY	20	9.48e-01	0.008350	9.78e-01
REACTOME CALCINEURIN ACTIVATES NFAT	9	9.49e-01	-0.012400	9.78e-01
REACTOME FASL CD95L SIGNALING	5	9.49e-01	-0.016400	9.78e-01
REACTOME CA DEPENDENT EVENTS	36	9.50e-01	-0.006030	9.78e-01
REACTOME CALCITONIN LIKE LIGAND RECEPTORS	10	9.50e-01	-0.011400	9.78e-01
REACTOME ADRENOCEPTORS	9	9.50e-01	0.012000	9.78e-01
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	12	9.51e-01	-0.010200	9.78e-01
REACTOME SIGNALING BY ERYTHROPOIETIN	25	9.51e-01	0.007030	9.78e-01
REACTOME DEVELOPMENTAL BIOLOGY	1115	9.52e-01	0.001070	9.78e-01
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	14	9.52e-01	-0.009250	9.78e-01
REACTOME ENDOGENOUS STEROLS	26	9.53e-01	0.006730	9.78e-01
REACTOME ACTIVATED NTRK2 SIGNALS THROUGH PI3K	7	9.55e-01	0.012400	9.79e-01
REACTOME ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	59	9.55e-01	0.004260	9.79e-01
REACTOME STAT5 ACTIVATION	7	9.56e-01	0.012000	9.79e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	29	9.57e-01	0.005760	9.80e-01
REACTOME SIGNALING BY FLT3 FUSION PROTEINS	19	9.59e-01	0.006840	9.81e-01
REACTOME INLA MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS	9	9.60e-01	0.009640	9.82e-01
REACTOME NETRIN MEDIATED REPULSION SIGNALS	8	9.61e-01	-0.009900	9.82e-01
REACTOME PURINE SALVAGE	12	9.62e-01	0.007930	9.82e-01
REACTOME MOLYBDENUM COFACTOR BIOSYNTHESIS	6	9.62e-01	-0.011100	9.82e-01
REACTOME NEUROFASCIN INTERACTIONS	6	9.63e-01	0.011100	9.82e-01
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	11	9.64e-01	-0.007800	9.82e-01
REACTOME SEROTONIN RECEPTORS	11	9.64e-01	0.007800	9.82e-01
REACTOME SIGNALING BY ERBB4	57	9.64e-01	-0.003410	9.82e-01
REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	38	9.65e-01	-0.004110	9.82e-01
REACTOME CONJUGATION OF BENZOATE WITH GLYCINE	6	9.66e-01	-0.009940	9.83e-01
REACTOME SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION	8	9.67e-01	0.008440	9.83e-01
REACTOME ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	74	9.69e-01	-0.002590	9.84e-01
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	21	9.69e-01	0.004830	9.84e-01
REACTOME PEPTIDE HORMONE METABOLISM	84	9.71e-01	0.002270	9.85e-01
REACTOME RHO GTPASES ACTIVATE NADPH OXIDASES	21	9.73e-01	-0.004290	9.86e-01
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	20	9.75e-01	-0.004020	9.88e-01
REACTOME BETA OXIDATION OF LAUROYL COA TO DECANOYL COA COA	5	9.76e-01	-0.007930	9.88e-01
REACTOME PEROXISOMAL LIPID METABOLISM	28	9.76e-01	0.003270	9.88e-01
REACTOME SULFIDE OXIDATION TO SULFATE	6	9.77e-01	0.006860	9.88e-01
REACTOME TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	43	9.79e-01	0.002280	9.90e-01
REACTOME SURFACTANT METABOLISM	28	9.82e-01	-0.002450	9.92e-01
REACTOME HEMOSTASIS	591	9.84e-01	0.000497	9.92e-01
REACTOME METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	33	9.84e-01	0.001990	9.92e-01
REACTOME AZATHIOPRINE ADME	22	9.84e-01	0.002440	9.92e-01
REACTOME RIBAVIRIN ADME	11	9.86e-01	0.002980	9.94e-01
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	11	9.88e-01	0.002660	9.94e-01
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	52	9.88e-01	-0.001210	9.94e-01
REACTOME DEFECTIVE CSF2RB CAUSES SMDP5	7	9.92e-01	-0.002170	9.96e-01
REACTOME RND1 GTPASE CYCLE	41	9.93e-01	0.000824	9.96e-01
REACTOME RNA POLYMERASE III CHAIN ELONGATION	18	9.93e-01	0.001220	9.96e-01
REACTOME ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	18	9.94e-01	-0.001080	9.96e-01
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	26	9.94e-01	0.000885	9.96e-01
REACTOME RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION	6	9.94e-01	-0.001790	9.96e-01
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	45	9.95e-01	-0.000589	9.96e-01
REACTOME REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	11	9.95e-01	0.001020	9.97e-01
REACTOME REGULATION OF SIGNALING BY CBL	22	9.96e-01	-0.000595	9.97e-01
REACTOME GAB1 SIGNALOSOME	17	9.99e-01	-0.000214	9.99e-01

---

Detailed Gene set reports

REACTOME_METABOLISM_OF_RNA

REACTOME_METABOLISM_OF_RNA

	1313
set	REACTOME_METABOLISM_OF_RNA
setSize	675
pANOVA	5.95e-19
s.dist	0.201
p.adjustANOVA	9.78e-16

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SKIC8	11483
UPF1	11467
ZFP36	11423
RPL39L	11403
GLE1	11355
THUMPD1	11299
DDX39B	11243
DDX1	11163
PSMD3	11142
SARNP	11065
UTP14C	11061
TXNL4A	11060
WDR3	11008
AQR	10996
APOBEC2	10976
SF3B6	10955
PWP2	10897
NUP37	10891
SNRNP70	10869
SNRPC	10840

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SKIC8	11483.0
UPF1	11467.0
ZFP36	11423.0
RPL39L	11403.0
GLE1	11355.0
THUMPD1	11299.0
DDX39B	11243.0
DDX1	11163.0
PSMD3	11142.0
SARNP	11065.0
UTP14C	11061.0
TXNL4A	11060.0
WDR3	11008.0
AQR	10996.0
APOBEC2	10976.0
SF3B6	10955.0
PWP2	10897.0
NUP37	10891.0
SNRNP70	10869.0
SNRPC	10840.0
EXOSC9	10825.0
WDR12	10786.0
CWC25	10723.0
PHF5A	10688.0
SRRM1	10636.0
RPS24	10632.0
APOBEC3C	10626.0
HBS1L	10579.0
PRMT5	10556.0
HNRNPL	10528.0
RBM22	10483.0
EXOSC3	10479.0
TRMT44	10473.0
PRPF8	10442.0
CPSF1	10424.0
PSMC1	10399.0
SF3B4	10367.0
EBNA1BP2	10362.0
APOBEC1	10344.0
APOBEC4	10322.0
SNRNP27	10314.0
NIP7	10306.0
HNRNPK	10300.0
SNRPD2	10271.0
GTF2F1	10225.0
ZFP36L1	10195.0
PSMB1	10173.0
POLR2E	10170.0
UBA52	10169.0
SNRPF	10159.0
MAPK14	10146.0
NUP85	10105.0
SF1	10096.0
HEATR1	10026.0
GTF2H5	10024.0
TSR1	10023.0
NOP2	10004.0
DDX20	9996.0
RPL26	9894.0
PSMC6	9892.0
PRPF18	9854.0
RPL27	9834.0
RIOK2	9769.0
NCL	9768.0
RPP38	9763.0
EIF4A1	9727.0
U2AF1L4	9713.0
FAM32A	9712.0
XPO1	9708.0
DDX42	9704.0
SUPT5H	9702.0
NCBP2	9630.0
HNRNPM	9623.0
ELAVL1	9604.0
RRP7A	9602.0
SRRT	9591.0
RNPC3	9589.0
TRMT61B	9559.0
WBP4	9550.0
ISY1	9535.0
PAIP1	9519.0
TGS1	9515.0
NAT10	9505.0
DDX5	9484.0
SF3B5	9442.0
NCBP1	9433.0
DHX8	9422.0
UPF3A	9413.0
KRR1	9396.0
WDR77	9377.0
DNAJC8	9352.0
SRSF1	9323.0
EIF4G1	9315.0
PSMD4	9234.0
NXF1	9220.0
GEMIN4	9188.0
RPP40	9124.0
WDR43	9091.0
SMG7	9072.0
YJU2	9024.0
SEH1L	8981.0
KHSRP	8971.0
NOP14	8952.0
SDE2	8942.0
GTF2H1	8877.0
MRM3	8833.0
YWHAB	8801.0
DHX37	8774.0
GPATCH1	8758.0
CPSF6	8756.0
PSME3	8732.0
POLR2D	8613.0
MAGOHB	8573.0
GTF2H3	8555.0
DIS3	8527.0
RPL10A	8486.0
PUF60	8478.0
CDC40	8444.0
ZNF830	8437.0
PSMD13	8389.0
SMG1	8366.0
GSPT1	8361.0
CLNS1A	8360.0
RPS14	8357.0
QTRT2	8315.0
RPL24	8299.0
NUP88	8287.0
UTP4	8272.0
RPS20	8266.0
NUP42	8255.0
TSEN34	8244.0
BCAS2	8233.0
PPIG	8231.0
YWHAZ	8195.0
RPS27	8146.0
CSTF2T	8143.0
EXOSC8	8126.0
FAU	8073.0
ZMAT5	8063.0
PARN	8054.0
RPS5	8053.0
SMN1	8042.5
SMN2	8042.5
RBM42	8029.0
TCERG1	8023.0
ETF1	7992.0
PSMC3	7956.0
PPP1R8	7934.0
SNRPB2	7928.0
RPL35	7924.0
TRIT1	7830.0
NUP62	7784.0
PCBP2	7782.0
SNU13	7775.0
ZMAT2	7753.0
PSMA3	7703.0
LENG1	7689.0
SMNDC1	7668.0
SMG9	7610.0
ELAC2	7603.0
RPL36	7593.0
RRP36	7576.0
PCBP1	7569.0
DHX16	7471.0
PCF11	7470.0
METTL14	7463.0
POP5	7449.0
TPR	7435.0
OSGEP	7399.0
PRPF38A	7395.0
DCAF13	7394.0
RBM17	7389.0
PSMD7	7334.0
CPSF4	7318.0
RANBP2	7289.0
TYW5	7214.0
CTU2	7205.0
MRM2	7154.0
DUS2	7153.0
NHP2	7105.0
USP39	7097.0
UBL5	7094.0
THOC1	7060.0
SNRPD1	7057.0
CPSF7	7056.0
DHX38	7051.0
BUD31	7034.0
TRMT10C	7032.0
NUP93	6988.0
HNRNPF	6963.0
PPIL1	6953.0
EXOSC10	6925.0
RPS15	6917.0
ADAR	6912.0
RPS7	6908.0
PSMA7	6898.0
PSMA1	6861.0
RNMT	6733.0
NUDT21	6723.0
NUP214	6722.0
CSTF3	6719.0
FUS	6711.0
RPL22	6685.0
EXOSC6	6642.0
AKT1	6607.0
PPIE	6595.0
RPL37A	6589.0
PSMB2	6549.0
RPL5	6546.0
TYW1	6529.0
PSMC4	6484.0
CSTF1	6481.0
RPS18	6474.0
FIP1L1	6458.0
RAE1	6386.0
UBB	6377.0
NOC4L	6373.0
WDR33	6333.0
RPP21	6307.0
EXOSC2	6293.0
CPSF2	6288.0
WDR46	6282.0
NUP153	6267.0
PSMD9	6250.0
CWC22	6173.0
RPPH1	6122.0
NUP188	6088.0
BMS1	6062.0
WDR4	6056.0
ZBTB8OS	6048.0
PAPOLA	6042.0
SF3A1	6031.0
GAR1	5979.0
PPIL2	5968.0
RPP25	5963.0
PSMD14	5956.0
HNRNPA3	5950.0
PRPF31	5923.0
EFTUD2	5901.0
PATL1	5888.0
CDC5L	5869.0
TRMT5	5838.0
NUP54	5830.0
SRSF12	5821.0
SF3A2	5798.0
PSMA6	5773.0
RTCB	5637.0
HNRNPA2B1	5614.0
SYF2	5609.0
ANP32A	5599.0
RPS6	5583.0
LSM10	5521.0
NUP133	5499.0
DDX23	5444.0
SKIC2	5440.0
PSME2	5380.0
CTU1	5372.0
FBL	5371.0
RPL13	5324.0
PSMD11	5320.0
TEX10	5308.0
POLR2I	5240.0
CSNK1D	5214.0
PPWD1	5202.0
IMP3	5186.0
RPL18	5130.0
DDX6	5128.0
XPOT	5096.0
THOC6	5090.0
THOC5	5071.0
PSMB5	5052.0
EXOSC5	5051.0
EDC3	5045.0
POLR2A	5042.0
RPL11	5014.0
SNRNP200	5003.0
TRA2B	5002.0
NOB1	4999.0
QTRT1	4946.0
RPLP2	4945.0
RPL37	4942.0
SNW1	4927.0
RPL7	4893.0
NUP58	4880.0
PUS3	4857.0
RPL19	4852.0
PSMB3	4835.0
LTV1	4801.0
SUGP1	4734.0
AAAS	4718.0
SLBP	4710.0
TRMT1	4675.0
ZC3H11A	4653.0
RPL3L	4652.0
FYTTD1	4619.0
PHAX	4608.0
TRMT10A	4593.0
URM1	4538.0
SNRPA1	4531.0
SLU7	4525.0
NSUN2	4470.0
SNRNP35	4449.0
SRSF3	4433.0
PAN2	4416.0
HNRNPD	4380.0
NUP107	4332.0
DHX35	4323.0
SF3A3	4277.0
CNOT11	4259.0
NDC1	4258.0
DDX46	4257.0
PSME4	4171.0
POLR2F	4146.0
SRSF9	4130.0
ADAT2	4087.0
CNOT2	4080.0
TFIP11	4038.0
UTP18	4026.0
RPL8	4020.0
RBM28	3998.0
PSMD12	3928.0
CNOT1	3890.0
PNRC2	3872.0
SNRPA	3859.0
MPHOSPH6	3791.0
SART1	3784.0
POLR2H	3756.0
CNOT3	3742.0
SNRPD3	3720.0
PSMD5	3711.0
RPS23	3706.0
RPS13	3696.0
PSMB8	3681.0
MRM1	3676.0
NOL9	3663.0
ADAT3	3658.0
PSMA4	3640.0
POP7	3625.0
MPHOSPH10	3623.0
RPS11	3544.0
SRSF6	3503.0
RPLP0	3496.0
THG1L	3475.0
PTBP1	3420.0
DDX52	3393.0
WBP11	3381.0
PNN	3310.0
CDK7	3307.0
XRN2	3245.0
UPF2	3244.0
ADARB1	3243.0
EIF4E	3219.0
DHX9	3150.0
PSMD1	3063.0
NSRP1	3053.0
FTSJ3	3040.0
HNRNPU	2870.0
LSM6	2858.0
CHERP	2852.0
METTL3	2820.0
TRMT112	2809.0
NUP43	2770.0
SF3B2	2742.0
LSM5	2677.0
TRMT13	2661.0
CNOT4	2602.0
TFB1M	2592.0
NOP10	2587.0
ISG20L2	2585.0
CCAR1	2582.0
RTRAF	2577.0
RPL27A	2534.0
NUP98	2445.0
RPS21	2412.0
EIF4B	2411.0
RPL30	2387.0
ZCRB1	2379.0
PSMB9	2322.0
A1CF	2313.0
PPIH	2293.0
SAP18	2286.0
RPL35A	2255.0
PRPF4	2214.0
MAPK11	2152.0
GEMIN2	2137.0
HSPA8	2120.0
CNOT9	2082.0
RPS2	2069.0
RPL3	2052.0
NUP160	2051.0
DDX49	2004.0
TBL3	1987.0
TSR3	1974.0
TSEN54	1937.0
LSM4	1925.0
WTAP	1921.0
LUC7L3	1917.0
RBM39	1886.0
WDR36	1884.0
RPL18A	1823.0
DCP1A	1817.0
GCFC2	1807.0
DCP2	1742.0
TRMT61A	1728.0
ADAT1	1725.0
PRKRIP1	1536.0
NSUN6	1531.0
PSMC5	1519.0
RPL7A	1463.0
SMG6	1460.0
SNRNP40	1428.0
THADA	1392.0
TUT7	1374.0
RBM25	1372.0
PPP2CA	1345.0
UTP11	1318.0
TPRKB	1304.0
NSUN4	1296.0
CRNKL1	1295.0
RPS3	1291.0
EXOSC4	1271.0
THOC7	1161.0
RIOK1	1160.0
XRN1	1110.0
MNAT1	1066.0
NOP58	1062.0
GTF2H4	1040.0
RPL36AL	1019.5
POLR2B	1016.0
SRRM2	1013.0
PDCD7	996.0
CNOT7	961.0
SRSF2	951.0
UTP15	928.0
RPP14	904.0
SMG5	873.0
PPP2R1A	849.0
SNIP1	816.0
MAPKAPK2	775.0
PRPF40A	759.0
PRKCD	733.0
SRSF11	669.0
GTPBP3	617.0
TUT4	591.0
RPS27L	566.0
PDCD11	559.0
PPIL4	528.0
WDR70	500.0
LSM2	496.0
PAN3	493.0
U2AF2	490.0
PABPN1	485.0
RPL26L1	476.0
CASC3	449.0
C2orf49	441.0
ALYREF	429.0
CNOT10	382.0
RPL6	325.0
SF3B1	262.0
PUS7	249.0
BYSL	209.0
RPS9	183.0
LSM11	159.0
RPS10	102.0
BUD13	96.0
SRSF4	47.0
PSMF1	4.0
POP4	-17.0
MTERF4	-21.0
SENP3	-66.0
SKIC3	-80.0
FAM98B	-130.0
RBM8A	-178.0
RNPS1	-231.0
RPS3A	-233.0
LSM7	-245.0
RPS26	-319.0
U2SURP	-322.0
POLR2G	-351.0
SNRPB	-401.0
SEM1	-434.0
PELP1	-455.0
IMP4	-460.0
TNPO1	-470.0
PLRG1	-537.0
HNRNPR	-543.0
RPL9	-564.0
ZNF473	-566.0
PRKCA	-589.0
PRORP	-651.0
POLDIP3	-663.0
NUP35	-710.0
NOL6	-716.0
EPRS1	-737.0
RAN	-745.0
RPS19	-748.0
SF3B3	-785.0
CNOT8	-790.0
POLR2K	-795.0
LSM8	-818.0
PSMC2	-844.0
EDC4	-852.0
RPS25	-928.0
SNRPG	-949.0
PABPC1	-955.0
LSM3	-972.0
CWC27	-1023.0
PPIL3	-1034.0
DDX21	-1067.0
RPL17	-1074.0
SNUPN	-1115.0
RPS15A	-1190.0
RPL31	-1191.0
CACTIN	-1225.0
PUS1	-1299.0
RPL41	-1400.0
UTP3	-1415.0
RPL21	-1464.0
RBM5	-1483.0
POLR2C	-1547.0
RPS28	-1593.0
WDR75	-1596.0
SEC13	-1604.0
UTP6	-1641.0
MTREX	-1644.0
MAGOH	-1713.0
PRPF19	-1758.0
RPS29	-1802.0
RPL4	-1976.0
UTP20	-1990.0
DDX41	-2007.0
TSEN2	-2022.0
SRSF5	-2055.0
RPL14	-2101.0
SMG8	-2120.0
PSMD6	-2201.0
DCP1B	-2206.0
HNRNPC	-2240.0
GEMIN6	-2249.0
PSMD8	-2294.0
DIMT1	-2319.0
CWC15	-2330.0
GEMIN7	-2369.0
RIOK3	-2388.0
PPP2R2A	-2391.0
TRNT1	-2412.0
RPS16	-2419.0
RPS27A	-2472.0
SNRNP48	-2487.0
DDX39A	-2492.0
C1D	-2500.0
NOL11	-2551.0
TP53RK	-2553.0
RRP9	-2578.0
EXOSC7	-2604.0
EIF4A3	-2617.0
METTL1	-2623.0
TRDMT1	-2698.0
PSMA2	-2726.0
GNL3	-2739.0
PNO1	-2790.0
NOP56	-2797.0
EMG1	-2798.0
FCF1	-2838.0
TRMU	-2907.0
UTP25	-2959.0
NUP205	-3003.0
RPLP1	-3066.0
GTF2F2	-3076.0
IK	-3135.0
PRCC	-3164.0
PSMB4	-3191.0
RPL12	-3217.0
RPL38	-3220.0
MTO1	-3294.0
ACIN1	-3308.0
RPL32	-3366.0
BUD23	-3396.0
RPL28	-3461.0
PSMA8	-3478.0
GEMIN5	-3494.0
NUP50	-3509.0
HSPA1A	-3563.0
CWF19L2	-3618.0
CNOT6	-3666.0
NUP210	-3669.0
CTNNBL1	-3709.0
RNGTT	-3846.0
TRMT11	-3864.0
POM121	-3922.0
EXOSC1	-3957.0
PSMB10	-3966.0
XAB2	-3998.0
SET	-4012.0
RPL15	-4110.0
WDR18	-4242.0
PES1	-4261.0
PSMA5	-4274.0
IGF2BP3	-4290.0
RPL29	-4307.0
MFAP1	-4449.0
SRSF10	-4497.0
IGF2BP1	-4544.0
TRMT6	-4573.0
RBM7	-4612.0
HNRNPH1	-4659.0
BOP1	-4666.0
IGF2BP2	-4675.0
APOBEC3A	-4748.0
PSMB6	-4786.0
CHTOP	-4796.0
HNRNPA1	-4801.0
SRSF7	-4925.0
RPL22L1	-5004.0
NXT1	-5022.0
CPSF3	-5038.0
SRSF8	-5041.0
LSM1	-5082.0
RPS8	-5241.0
PSMB7	-5258.0
NOL12	-5293.0
CNOT6L	-5295.0
RRP1	-5326.0
APOBEC3H	-5355.0
ERCC3	-5361.0
DDX47	-5362.0
ALKBH8	-5372.0
TNKS1BP1	-5522.0
TRMT12	-5614.0
POP1	-5746.0
RPSA	-5754.0
ERCC2	-5783.0
DHX15	-5864.0
TSEN15	-5898.0
NUP155	-5949.0
TRMT9B	-5999.0
HSPB1	-6020.0
RPL34	-6070.0
SYMPK	-6153.0
PSMD2	-6176.0
NT5C3B	-6242.0
PRPF6	-6253.0
EIF4A2	-6271.0
THOC3	-6299.0
CLP1	-6423.0
YBX1	-6440.0
ERI1	-6509.0
CDKAL1	-6594.0
RCL1	-6667.0
SNRNP25	-6687.0
UBC	-6842.0
PRPF3	-6898.0
SMU1	-6901.0
APOBEC3B	-7018.0
SNRPE	-7134.0
DCPS	-7225.0
RPP30	-7497.0
RPL23	-7518.0
CCNH	-7541.0
SNRPN	-7665.0
POLR2L	-7683.0
PSME1	-7763.0
RPL13A	-7929.5
RPS12	-8043.0
POM121C	-8073.0
TYW3	-8080.0
C9orf78	-8096.0
RPL23A	-8127.0
CCDC12	-8221.0
PSMB11	-8541.0
LCMT2	-8666.0
CSNK1E	-8775.0
POLR2J	-9382.0
TNFSF13	-9435.0
RPL10L	-9546.0

---

REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

	1146
set	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA
setSize	263
pANOVA	2.82e-12
s.dist	0.25
p.adjustANOVA	2.32e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GLE1	11355
DDX39B	11243
SARNP	11065
TXNL4A	11060
AQR	10996
SF3B6	10955
NUP37	10891
SNRNP70	10869
SNRPC	10840
CWC25	10723
PHF5A	10688
SRRM1	10636
HNRNPL	10528
RBM22	10483
PRPF8	10442
CPSF1	10424
SF3B4	10367
SNRNP27	10314
HNRNPK	10300
SNRPD2	10271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GLE1	11355
DDX39B	11243
SARNP	11065
TXNL4A	11060
AQR	10996
SF3B6	10955
NUP37	10891
SNRNP70	10869
SNRPC	10840
CWC25	10723
PHF5A	10688
SRRM1	10636
HNRNPL	10528
RBM22	10483
PRPF8	10442
CPSF1	10424
SF3B4	10367
SNRNP27	10314
HNRNPK	10300
SNRPD2	10271
GTF2F1	10225
POLR2E	10170
SNRPF	10159
NUP85	10105
SF1	10096
PRPF18	9854
U2AF1L4	9713
FAM32A	9712
DDX42	9704
NCBP2	9630
HNRNPM	9623
SRRT	9591
RNPC3	9589
WBP4	9550
ISY1	9535
DDX5	9484
SF3B5	9442
NCBP1	9433
DHX8	9422
DNAJC8	9352
SRSF1	9323
NXF1	9220
YJU2	9024
SEH1L	8981
SDE2	8942
GPATCH1	8758
CPSF6	8756
POLR2D	8613
MAGOHB	8573
PUF60	8478
CDC40	8444
ZNF830	8437
NUP88	8287
NUP42	8255
BCAS2	8233
PPIG	8231
CSTF2T	8143
ZMAT5	8063
RBM42	8029
TCERG1	8023
PPP1R8	7934
SNRPB2	7928
NUP62	7784
PCBP2	7782
SNU13	7775
ZMAT2	7753
LENG1	7689
SMNDC1	7668
PCBP1	7569
DHX16	7471
PCF11	7470
METTL14	7463
TPR	7435
PRPF38A	7395
RBM17	7389
CPSF4	7318
RANBP2	7289
USP39	7097
UBL5	7094
THOC1	7060
SNRPD1	7057
CPSF7	7056
DHX38	7051
BUD31	7034
NUP93	6988
HNRNPF	6963
PPIL1	6953
NUDT21	6723
NUP214	6722
CSTF3	6719
FUS	6711
PPIE	6595
CSTF1	6481
FIP1L1	6458
RAE1	6386
WDR33	6333
CPSF2	6288
NUP153	6267
CWC22	6173
NUP188	6088
PAPOLA	6042
SF3A1	6031
PPIL2	5968
HNRNPA3	5950
PRPF31	5923
EFTUD2	5901
CDC5L	5869
NUP54	5830
SRSF12	5821
SF3A2	5798
HNRNPA2B1	5614
SYF2	5609
NUP133	5499
DDX23	5444
POLR2I	5240
PPWD1	5202
THOC6	5090
THOC5	5071
POLR2A	5042
SNRNP200	5003
TRA2B	5002
SNW1	4927
NUP58	4880
SUGP1	4734
AAAS	4718
SLBP	4710
ZC3H11A	4653
FYTTD1	4619
SNRPA1	4531
SLU7	4525
SNRNP35	4449
SRSF3	4433
HNRNPD	4380
NUP107	4332
DHX35	4323
SF3A3	4277
NDC1	4258
DDX46	4257
POLR2F	4146
SRSF9	4130
TFIP11	4038
SNRPA	3859
SART1	3784
POLR2H	3756
SNRPD3	3720
SRSF6	3503
PTBP1	3420
WBP11	3381
PNN	3310
EIF4E	3219
DHX9	3150
NSRP1	3053
HNRNPU	2870
LSM6	2858
CHERP	2852
METTL3	2820
NUP43	2770
SF3B2	2742
LSM5	2677
CCAR1	2582
NUP98	2445
ZCRB1	2379
PPIH	2293
SAP18	2286
PRPF4	2214
HSPA8	2120
NUP160	2051
LSM4	1925
WTAP	1921
LUC7L3	1917
RBM39	1886
GCFC2	1807
PRKRIP1	1536
SNRNP40	1428
RBM25	1372
CRNKL1	1295
THOC7	1161
POLR2B	1016
SRRM2	1013
PDCD7	996
SRSF2	951
SNIP1	816
PRPF40A	759
SRSF11	669
PPIL4	528
WDR70	500
LSM2	496
U2AF2	490
PABPN1	485
CASC3	449
ALYREF	429
SF3B1	262
BUD13	96
SRSF4	47
RBM8A	-178
RNPS1	-231
LSM7	-245
U2SURP	-322
POLR2G	-351
SNRPB	-401
PLRG1	-537
HNRNPR	-543
POLDIP3	-663
NUP35	-710
SF3B3	-785
POLR2K	-795
LSM8	-818
SNRPG	-949
LSM3	-972
CWC27	-1023
PPIL3	-1034
CACTIN	-1225
RBM5	-1483
POLR2C	-1547
SEC13	-1604
MTREX	-1644
MAGOH	-1713
PRPF19	-1758
DDX41	-2007
SRSF5	-2055
HNRNPC	-2240
CWC15	-2330
SNRNP48	-2487
DDX39A	-2492
EIF4A3	-2617
NUP205	-3003
GTF2F2	-3076
IK	-3135
PRCC	-3164
ACIN1	-3308
NUP50	-3509
CWF19L2	-3618
NUP210	-3669
CTNNBL1	-3709
POM121	-3922
XAB2	-3998
MFAP1	-4449
SRSF10	-4497
RBM7	-4612
HNRNPH1	-4659
CHTOP	-4796
HNRNPA1	-4801
SRSF7	-4925
NXT1	-5022
CPSF3	-5038
SRSF8	-5041
DHX15	-5864
NUP155	-5949
SYMPK	-6153
PRPF6	-6253
THOC3	-6299
CLP1	-6423
YBX1	-6440
SNRNP25	-6687
PRPF3	-6898
SMU1	-6901
SNRPE	-7134
SNRPN	-7665
POLR2L	-7683
POM121C	-8073
C9orf78	-8096
CCDC12	-8221
POLR2J	-9382

---

REACTOME_KERATINIZATION

REACTOME_KERATINIZATION

	1073
set	REACTOME_KERATINIZATION
setSize	210
pANOVA	1.51e-11
s.dist	-0.27
p.adjustANOVA	8.29e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRT17	-10182
SPRR2E	-10134
KRTAP21-1	-10032
KRTAP13-4	-9972
KRTAP19-8	-9950
LCE3D	-9941
LIPN	-9929
KRTAP5-2	-9915
KRTAP19-5	-9893
KRTAP19-4	-9877
KRT82	-9875
KRTAP1-1	-9842
KRT71	-9807
KRT37	-9764
KRTAP8-1	-9755
KRTAP10-9	-9667
KRTAP9-1	-9560
CSTA	-9499
KRTAP15-1	-9451
KRTAP2-4	-9441

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRT17	-10182
SPRR2E	-10134
KRTAP21-1	-10032
KRTAP13-4	-9972
KRTAP19-8	-9950
LCE3D	-9941
LIPN	-9929
KRTAP5-2	-9915
KRTAP19-5	-9893
KRTAP19-4	-9877
KRT82	-9875
KRTAP1-1	-9842
KRT71	-9807
KRT37	-9764
KRTAP8-1	-9755
KRTAP10-9	-9667
KRTAP9-1	-9560
CSTA	-9499
KRTAP15-1	-9451
KRTAP2-4	-9441
LCE1B	-9380
KRTAP2-2	-9350
KRTAP5-8	-9347
LCE3E	-9310
KRTAP24-1	-9260
KRT4	-9237
KRTAP16-1	-9173
KRTAP29-1	-9128
KRTAP13-1	-9110
LCE2B	-9107
FLG	-9083
KRT76	-9073
KRT33B	-9047
KRT26	-9036
KRTAP13-2	-9030
FURIN	-8937
KRTAP10-3	-8863
KRTAP5-1	-8840
KRT75	-8815
KRTAP11-1	-8794
KRTAP5-5	-8780
SPRR1B	-8770
KRTAP19-6	-8674
KRTAP3-2	-8657
KLK8	-8653
KRTAP4-7	-8629
SPRR3	-8621
LCE1A	-8504
KRT28	-8484
SPRR2G	-8469
KRT25	-8432
KRT38	-8395
KRTAP13-3	-8379
KRT40	-8371
KRTAP6-3	-8284
LCE5A	-8282
KRT83	-8213
KRTAP12-1	-8155
KRT23	-8134
KRTAP10-5	-8100
KRT36	-7921
KRT32	-7862
KRT35	-7861
KRT84	-7812
KRT39	-7790
KRTAP10-11	-7722
LCE1E	-7719
DSC3	-7711
KRT2	-7689
LCE3B	-7667
LCE1C	-7592
KRT81	-7571
KRT86	-7532
KRTAP20-2	-7347
KRT18	-7317
KRTAP20-1	-7017
KRTAP9-3	-6834
TGM1	-6675
KRT77	-6634
LIPJ	-6514
IVL	-6496
KRT7	-6404
KRT5	-6397
DSG3	-6381
KRT6B	-6258
KRTAP4-2	-6161
DSG4	-6155
KRTAP9-2	-6062
KRT74	-5992
JUP	-5938
KRTAP21-2	-5935
KRTAP19-3	-5789
KRTAP17-1	-5467
KRT72	-5465
KRTAP19-2	-5159
KRT24	-4945
CASP14	-4823
KRTAP23-1	-4808
KAZN	-4716
TGM5	-4605
ST14	-4465
DSC2	-4413
KRTAP4-3	-4317
KRT80	-4243
KRTAP5-6	-4159
PCSK6	-3887
KRTAP5-11	-3428
KRT85	-3226
KRT31	-2892
KRT78	-2826
KRTAP10-4	-2748
KRTAP10-10	-2699
KRTAP9-6	-2493
KRTAP10-6	-2389
KRTAP5-4	-2355
KRTAP9-4	-2306
KRTAP12-2	-2131
SPRR2F	-2050
TCHH	-2010
KRTAP4-8	-1989
PI3	-1985
PERP	-1563
CAPNS1	-1294
KRT1	-1195
CDSN	-1012
KRT3	-985
LCE6A	-832
CELA2A	-813
KRTAP6-1	-782
SPINK5	-777
KRT20	84
KRT33A	173
KRTAP10-7	226
LCE1F	228
KRTAP9-9	487
PRSS8	547
DSP	687
SPRR2A	708
KRTAP12-4	793
KRTAP5-9	828
KRTAP27-1	840
PKP2	968
PKP3	1188
KRT79	1196
KRT6C	1294
SPRR2D	1356
KRTAP19-1	1367
KRTAP4-1	1377
KRTAP10-8	1535
DSG1	1747
KLK14	1983
KRT15	1988
DSG2	2032
KRTAP22-1	2307
KRTAP6-2	2381
KRTAP1-5	2477
LIPK	2563
KRT9	2624
RPTN	2772
SPRR1A	3302
KRTAP10-12	3662
KRTAP5-7	3963
LCE2A	4078
KRTAP26-1	4086
KRT12	4200
KRTAP19-7	4306
KRT27	4351
PPL	4930
EVPL	5063
KRT10	5086
SPINK6	5100
KRTAP10-1	5142
KRT16	5158
LCE4A	5469
KLK5	6051
PKP4	6125
KRTAP2-1	6156
KRTAP12-3	6212
KRT6A	6384
KRTAP4-5	6455
KLK12	6913
KRTAP2-3	7464
CAPN1	7465
KRTAP5-3	7894
LCE2C	8509
LCE2D	8590
KRTAP1-3	8639
SPINK9	8652
LIPM	8674
KRT13	8967
PKP1	9133
LELP1	9165
KRT8	9177
KRTAP3-1	9328
KRT34	9616
KRT19	9928
KRT73	9988
LCE3A	10151
KRTAP25-1	10489
KRTAP10-2	10523
DSC1	10542
KLK13	10584
KRTAP5-10	10647
KRT14	10844
KRTAP4-4	11044
KRTAP4-6	11349
KRTAP21-3	11352
KRTAP4-11	11474
KRTAP1-4	11628
KRTAP3-3	11685

---

REACTOME_CELL_CYCLE

REACTOME_CELL_CYCLE

	190
set	REACTOME_CELL_CYCLE
setSize	666
pANOVA	1.61e-10
s.dist	0.145
p.adjustANOVA	6.63e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MZT2A	11630
E2F4	11443
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
CDKN2B	11226
H2AC14	11207
DYNC1LI2	11173
PSMD3	11142
LIN37	11039
STAG3	10941
NUP37	10891
NSL1	10890
KIF23	10843
PPP6C	10759
PPP2R5D	10754
H2BC3	10676
POLA2	10669
RCC2	10660

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MZT2A	11630.0
E2F4	11443.0
TUBB8	11383.0
TUBB1	11311.0
DYNLL2	11280.0
MAPRE1	11267.0
CDKN2B	11226.0
H2AC14	11207.0
DYNC1LI2	11173.0
PSMD3	11142.0
LIN37	11039.0
STAG3	10941.0
NUP37	10891.0
NSL1	10890.0
KIF23	10843.0
PPP6C	10759.0
PPP2R5D	10754.0
H2BC3	10676.0
POLA2	10669.0
RCC2	10660.0
HAUS6	10657.0
DAXX	10654.0
H3C3	10604.0
FKBP6	10599.0
NCAPG	10503.0
PIAS4	10486.0
SIRT2	10431.0
ANKLE2	10427.0
PSMC1	10399.0
CHTF8	10384.0
HAUS8	10351.0
UBE2I	10324.0
TUBG1	10274.0
MIS18BP1	10272.0
PCNA	10230.0
H3C8	10202.0
CCNB2	10190.0
CDKN2D	10181.0
PSMB1	10173.0
BTRC	10171.0
POLR2E	10170.0
UBA52	10169.0
B9D2	10123.0
NUP85	10105.0
NUMA1	10088.0
ATR	10067.0
OIP5	10064.0
PSMC6	9892.0
ZW10	9885.0
ORC1	9866.0
CDC23	9833.0
LMNA	9748.0
XPO1	9708.0
ORC6	9596.0
TP53	9551.0
H2BC14	9533.0
CCNB1	9488.0
REC8	9471.0
RAB1A	9448.0
BUB1B	9436.0
CEP192	9411.0
RAB8A	9327.0
RMI1	9316.0
PPP2R5A	9306.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
CSNK2A1	9219.0
RPA3	9109.0
RAD9B	9100.0
H4C8	9007.0
CEP250	9005.0
RNF168	8997.0
POT1	8988.0
SEH1L	8981.0
FEN1	8951.0
POLE	8919.0
DNA2	8886.0
KPNB1	8882.0
SUN2	8820.0
YWHAB	8801.0
TERF1	8790.0
TFDP2	8771.0
KIF20A	8767.0
H2AZ1	8737.0
PSME3	8732.0
CENPF	8713.0
BIRC5	8644.0
RAD9A	8617.0
POLR2D	8613.0
BABAM1	8594.0
HJURP	8582.0
POLD1	8554.0
SFI1	8531.0
CTDNEP1	8494.0
TUBA1B	8427.0
H2AC8	8407.0
ANAPC10	8406.0
PSMD13	8389.0
KIF2A	8369.0
TUBGCP2	8356.0
STN1	8354.0
NUP88	8287.0
NUP42	8255.0
E2F1	8248.0
WRAP53	8235.0
YWHAZ	8195.0
TEX15	8191.0
RPA1	8165.0
CHMP7	8148.0
RPS27	8146.0
RTEL1	8103.0
CDK11B	8099.0
PRIM1	7996.0
PCM1	7980.0
ZWILCH	7966.0
PRKACA	7965.0
TUBGCP6	7958.0
PSMC3	7956.0
NINL	7898.0
MAX	7890.0
CHMP4B	7852.0
GORASP2	7847.0
WRN	7786.0
NUP62	7784.0
H4C5	7742.0
CENPJ	7729.0
PSMC3IP	7712.0
PSMA3	7703.0
HDAC1	7688.0
DYNC1H1	7672.0
CEP76	7665.0
AKAP9	7637.0
CDK4	7586.0
CENPC	7578.0
KNL1	7549.0
H2BC10	7509.0
RAD50	7503.0
GINS2	7478.0
PHLDA1	7473.0
CHEK1	7457.0
CCP110	7454.0
TPR	7435.0
TAOK1	7414.0
LIN52	7370.0
LEMD3	7365.0
PSMD7	7334.0
RANBP2	7289.0
PDS5A	7273.0
RUVBL2	7250.0
SPO11	7229.0
TERF2IP	7210.0
MCM5	7141.0
MIS18A	7139.0
MASTL	7138.0
NHP2	7105.0
CEP152	7035.0
NUP93	6988.0
DIDO1	6984.0
EML4	6970.0
CTC1	6966.0
PSMA7	6898.0
H4C3	6897.0
HAUS2	6862.0
PSMA1	6861.0
TOP3A	6789.0
NUP214	6722.0
RRM2	6698.0
MAU2	6663.0
AKT1	6607.0
CDC25C	6560.0
PSMB2	6549.0
BANF1	6504.0
PSMC4	6484.0
ATM	6477.0
KIF2C	6395.0
RAE1	6386.0
UBB	6377.0
MCM7	6360.0
CDC16	6332.0
CDK1	6313.0
CENPO	6310.0
CNTRL	6286.0
PCNT	6271.0
NUP153	6267.0
PSMD9	6250.0
TUBB4B	6227.0
SRC	6197.0
DCTN1	6189.0
CEP57	6168.0
TFDP1	6154.0
KIF18A	6129.0
SKP2	6108.0
DYRK1A	6100.0
NUP188	6088.0
TUBB2B	6024.0
PPP2R5B	6021.0
CENPK	6007.0
SMARCA5	6005.0
SMC2	6000.0
MLH3	5995.0
ITGB3BP	5989.0
GAR1	5979.0
PSMD14	5956.0
MYC	5940.0
MZT2B	5904.0
AKT2	5870.0
NUP54	5830.0
TEN1	5781.0
RBX1	5779.0
H4C9	5774.0
PSMA6	5773.0
RANGAP1	5723.0
HAUS5	5711.0
RB1	5689.0
EP300	5668.0
ESCO1	5626.0
PKMYT1	5593.0
CHMP2A	5566.0
ESCO2	5535.0
TUBG2	5534.0
CDCA5	5505.0
NUP133	5499.0
TUBA1A	5468.0
MCM8	5436.0
PSME2	5380.0
PSMD11	5320.0
UBE2S	5276.0
POLR2I	5240.0
CSNK1D	5214.0
ARPP19	5206.0
CHEK2	5205.0
PHF20	5189.0
TUBGCP3	5178.0
CDC26	5157.0
H2AC18	5121.5
H2AC19	5121.5
RFC2	5115.0
ANAPC1	5092.0
CDKN1B	5083.0
H2BC8	5070.0
SHQ1	5064.0
PSMB5	5052.0
POLR2A	5042.0
PIF1	5036.0
PLK4	5013.0
NSD2	4961.0
COP1	4959.0
SPAST	4952.0
NUP58	4880.0
IST1	4868.0
PSMB3	4835.0
PPP2R1B	4800.0
LPIN3	4771.0
GINS1	4752.0
AAAS	4718.0
SDCCAG8	4662.0
CKS1B	4659.0
CENPP	4572.0
RPA2	4484.0
RBL2	4475.0
PPP1CB	4467.0
AURKB	4455.0
TEX12	4412.0
DYNC1LI1	4367.0
NUF2	4365.0
DCTN3	4358.0
NUP107	4332.0
LCMT1	4327.0
ORC4	4299.0
NDEL1	4296.0
NDC1	4258.0
PMF1	4252.0
PSME4	4171.0
H3C1	4153.0
POLR2F	4146.0
MAD1L1	4118.0
PPP2R5C	4099.0
PPP1R12B	4074.0
H3-3A	4052.0
MDM2	4051.0
H2BC11	4044.0
GSK3B	4021.0
CLSPN	4002.0
CEP41	3962.0
PSMD12	3928.0
TOPBP1	3907.0
RBBP4	3906.0
CCNE2	3867.0
CDKN2A	3849.0
RAD17	3845.0
ANAPC7	3809.0
TUBB3	3788.0
NEDD1	3782.0
CSNK2B	3763.0
POLR2H	3756.0
CENPU	3739.0
PSMD5	3711.0
NCAPG2	3707.0
PSMB8	3681.0
PSMA4	3640.0
HMMR	3595.0
ORC2	3590.0
NBN	3589.0
RFC4	3563.0
MDC1	3549.0
MIS12	3486.0
CHMP6	3463.0
RCC1	3413.0
PCBP4	3406.0
UIMC1	3376.0
ANAPC5	3355.0
FZR1	3328.0
ANAPC4	3312.0
CDK7	3307.0
INCENP	3298.0
MAD2L1	3280.0
BUB3	3260.0
MCM3	3239.0
STAG1	3161.0
PRKCB	3154.0
H3C6	3151.0
TOP2A	3104.0
H2AX	3086.0
PSMD1	3063.0
MZT1	3049.0
CEP43	3035.0
CC2D1B	2982.0
CDC25B	2961.0
AURKA	2948.0
ORC5	2938.0
CNEP1R1	2920.0
GMNN	2913.0
RAD21	2837.0
NUP43	2770.0
CKAP5	2726.0
RAB1B	2714.0
CDC27	2701.0
LPIN2	2646.0
HAUS4	2636.0
NOP10	2587.0
PPME1	2539.0
SMC3	2481.0
WEE1	2466.0
CLASP1	2462.0
NUP98	2445.0
RFC3	2420.0
GOLGA2	2395.0
NIPBL	2366.0
ACD	2358.5
PPP2R5E	2327.0
PSMB9	2322.0
NCAPD3	2318.0
ALMS1	2281.0
PDS5B	2276.0
H4C1	2273.0
SYCE3	2259.0
RFC1	2245.0
CDK11A	2235.0
VPS4A	2225.0
DMC1	2215.0
HSP90AB1	2115.0
MAPK3	2077.0
NUP160	2051.0
ZWINT	2046.0
ANAPC2	1989.0
NDC80	1973.0
SYCP2	1958.0
DBF4	1954.0
NCAPD2	1923.0
CCNA2	1874.0
CCND1	1840.0
SSNA1	1783.0
KNTC1	1764.0
RSF1	1755.0
PLK1	1754.0
RMI2	1748.0
NEK6	1744.0
MDM4	1716.0
GTSE1	1709.0
GINS4	1702.0
YWHAH	1632.0
TINF2	1628.0
CDCA8	1598.0
PPP2R2D	1578.0
DSN1	1571.0
PSMC5	1519.0
CDC6	1513.0
H2AC6	1509.0
TUBA8	1505.0
BRCA1	1471.0
SKP1	1470.0
H4C4	1434.0
BUB1	1430.0
RBL1	1386.0
FBXO5	1384.0
UBE2D1	1355.0
PPP2CA	1345.0
ACTR1A	1341.0
CDC45	1297.0
ZNF385A	1287.0
MND1	1278.0
PAFAH1B1	1262.0
POLE2	1257.0
LIG1	1254.0
FKBPL	1249.0
DHFR	1192.0
RBBP8	1178.0
YWHAQ	1114.0
MNAT1	1066.0
POLR2B	1016.0
H3C2	1002.0
TERF2	954.0
JAK2	952.0
WAPL	929.0
MAPK1	915.0
FOXM1	905.0
ODF2	864.0
H3-3B	859.0
PPP2R1A	849.0
FBXL18	842.0
LIN54	826.0
ORC3	791.0
CSNK2A2	723.0
MSH4	697.0
MCPH1	680.0
E2F2	656.0
NCAPH	632.0
DYNC1I2	583.0
LEMD2	434.0
CDC7	394.0
CEP290	370.0
SGO2	363.0
MCM2	327.0
LPIN1	305.0
TUBB6	295.0
CENPT	266.0
CENPL	253.0
BABAM2	234.0
CDC25A	220.0
KMT5A	190.0
CEP72	143.0
BORA	129.0
CEP70	10.0
PSMF1	4.0
CEP135	-44.0
TK1	-164.0
RAD51	-172.0
H2BC1	-192.0
H2BC4	-260.0
MYBL2	-268.0
EXO1	-290.0
CEP131	-335.0
POLR2G	-351.0
H2BC5	-354.0
MRE11	-382.0
RAD1	-410.0
PPP1R12A	-430.0
SEM1	-434.0
TNPO1	-470.0
PRKCA	-589.0
CCND3	-628.0
VRK2	-660.0
LBR	-679.0
NUP35	-710.0
RAN	-745.0
SMC4	-771.0
POLR2K	-795.0
PSMC2	-844.0
PRIM2	-897.0
CDT1	-944.0
E2F6	-962.0
CDC20	-1019.0
CDK6	-1114.0
HSPA2	-1150.0
CDKN2C	-1154.0
SGO1	-1205.0
HUS1	-1275.0
CENPN	-1337.0
CLASP2	-1411.0
YWHAG	-1477.0
CENPQ	-1502.0
POLR2C	-1547.0
ABRAXAS1	-1564.0
AKT3	-1580.0
SEC13	-1604.0
PPP6R3	-1620.0
SYNE1	-1638.0
SUMO1	-1643.0
H3C11	-1655.0
H4C12	-1743.0
MCM4	-1749.0
H2BC12	-1772.0
SYCE2	-1836.0
CEP164	-1927.0
ABL1	-1929.0
NUDC	-1933.0
BLM	-1963.0
H2BC17	-2040.0
TMPO	-2048.0
PTTG1	-2073.0
DSCC1	-2108.0
H2BC21	-2129.0
MCM10	-2132.0
BARD1	-2156.0
GORASP1	-2164.0
PSMD6	-2201.0
CDKN1A	-2242.0
FBXW11	-2247.0
PSMD8	-2294.0
ENSA	-2320.0
LYN	-2322.0
TUBA4A	-2325.0
E2F5	-2329.0
CEP78	-2378.0
TUBA4B	-2380.0
PPP2R2A	-2391.0
ESPL1	-2406.0
MLH1	-2409.0
RPS27A	-2472.0
NEK7	-2483.0
USO1	-2498.0
ANAPC11	-2624.0
SKA1	-2643.0
RHNO1	-2686.0
PSMA2	-2726.0
CLIP1	-2732.0
H4C13	-2741.0
E2F3	-2835.0
BLZF1	-2904.0
BRCA2	-2940.0
AHCTF1	-2954.0
NUP205	-3003.0
CENPM	-3005.0
TP53BP1	-3024.0
H2BC6	-3080.0
H2BC15	-3142.0
PSMB4	-3191.0
YWHAE	-3214.0
POLD3	-3223.0
H2AC20	-3235.0
NCAPH2	-3256.0
HSP90AA1	-3286.0
AJUBA	-3295.0
H3-4	-3300.0
PPP1CC	-3357.0
H2AZ2	-3381.0
PSMA8	-3478.0
CDK5RAP2	-3491.0
NUP50	-3509.0
CENPS	-3513.0
SKA2	-3548.0
MSH5	-3590.0
PTK6	-3658.0
NDE1	-3667.0
NUP210	-3669.0
NEK9	-3707.0
TPX2	-3710.0
TUBGCP5	-3712.0
H2BC9	-3718.5
H3C7	-3718.5
LMNB1	-3736.0
UBE2V2	-3757.0
CENPW	-3834.0
CDKN1C	-3854.0
CHMP3	-3897.0
POM121	-3922.0
PSMB10	-3966.0
TUBA1C	-3972.0
HAUS1	-3989.0
ANAPC16	-4002.0
CCNE1	-4003.0
SET	-4012.0
RNF8	-4058.0
RFC5	-4136.0
ANAPC15	-4142.0
H2BC26	-4236.0
MCM6	-4245.0
BRIP1	-4248.0
VRK1	-4259.0
PSMA5	-4274.0
TUBB	-4279.0
CDC14A	-4381.0
PRDM9	-4403.0
SUN1	-4431.0
HERC2	-4445.0
CHTF18	-4472.0
SYCE1	-4501.0
CCNA1	-4580.0
KAT5	-4633.0
SFN	-4660.0
NME7	-4679.0
PSMB6	-4786.0
TUBGCP4	-4854.0
ATRIP	-4882.0
RAD51C	-4886.0
SYCP3	-4927.0
DYNLL1	-4954.0
POLE3	-4968.0
SPC25	-5044.0
CENPA	-5151.0
OPTN	-5157.0
PSMB7	-5258.0
DYNC1I1	-5309.0
HAUS3	-5315.0
DCTN2	-5318.0
UBE2C	-5371.0
POLD2	-5490.0
CHMP2B	-5574.0
CENPH	-5646.0
SMC1B	-5711.0
ANKRD28	-5843.0
LIN9	-5919.0
NUP155	-5949.0
CHMP4A	-5994.0
PRKAR2B	-6011.0
H2AJ	-6028.0
TUBA3D	-6078.0
PPP2CB	-6157.0
PSMD2	-6176.0
POLD4	-6372.0
CUL1	-6388.0
RUVBL1	-6422.0
H4C6	-6464.0
CDK2	-6684.0
SPC24	-6708.0
UBE2N	-6780.0
UBC	-6842.0
FBXL7	-6924.0
NPM1	-6941.0
H4C2	-6995.0
TUBB4A	-7113.0
CENPE	-7223.0
CCND2	-7243.0
RAB2A	-7245.0
NEK2	-7458.0
SYNE2	-7469.0
CCNH	-7541.0
UBE2E1	-7595.0
TUBA3C	-7603.0
TERT	-7659.0
POLR2L	-7683.0
TYMS	-7748.0
PSME1	-7763.0
CEP63	-7908.0
SYCP1	-7985.0
H3C4	-8000.0
TUBB2A	-8021.0
POLE4	-8070.0
POM121C	-8073.0
H2AC4	-8140.0
H3C10	-8206.0
GINS3	-8210.0
PSMB11	-8541.0
H2AC7	-8707.5
H2BC7	-8707.5
TUBA3E	-8723.0
CABLES1	-8728.0
SPDL1	-8769.0
CSNK1E	-8775.0
TUBAL3	-9053.0
H3C12	-9106.0
H2BC13	-9329.0
CHMP4C	-9374.0
POLR2J	-9382.0
KIF2B	-9529.0

---

REACTOME_OLFACTORY_SIGNALING_PATHWAY

REACTOME_OLFACTORY_SIGNALING_PATHWAY

	628
set	REACTOME_OLFACTORY_SIGNALING_PATHWAY
setSize	348
pANOVA	4.18e-10
s.dist	-0.195
p.adjustANOVA	1.37e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR2S2	-10171
OR52E6	-10079
OR5T3	-10074
OR52L1	-9971
OR52K2	-9914
OR4D11	-9851
OR10AG1	-9837
OR2V2	-9835
OR10G8	-9831
OR10H3	-9826
OR51F2	-9810
OR1S2	-9798
OR5M10	-9756
OR5B21	-9727
OR5C1	-9722
OR5M3	-9718
OR4K15	-9709
OR5B17	-9682
OR2L5	-9676
OR4C16	-9673

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR2S2	-10171.0
OR52E6	-10079.0
OR5T3	-10074.0
OR52L1	-9971.0
OR52K2	-9914.0
OR4D11	-9851.0
OR10AG1	-9837.0
OR2V2	-9835.0
OR10G8	-9831.0
OR10H3	-9826.0
OR51F2	-9810.0
OR1S2	-9798.0
OR5M10	-9756.0
OR5B21	-9727.0
OR5C1	-9722.0
OR5M3	-9718.0
OR4K15	-9709.0
OR5B17	-9682.0
OR2L5	-9676.0
OR4C16	-9673.0
OR6Q1	-9662.0
OR1F1	-9657.0
OR6B3	-9645.0
OR5AC2	-9638.0
OR6N1	-9636.0
OR10AD1	-9632.0
OR2V1	-9619.0
OR56B4	-9591.0
OR5P3	-9582.0
OR51T1	-9576.0
OR5I1	-9525.0
OR1A1	-9518.0
OR2AT4	-9517.0
OR5A2	-9516.0
OR10G7	-9513.0
OR8I2	-9501.0
OR52E4	-9468.0
OR4K13	-9439.0
OR7C1	-9416.0
OR5J2	-9413.0
OR51E1	-9410.0
OR10A3	-9314.0
OR10J3	-9303.0
OR14J1	-9257.0
OR5A1	-9216.0
OR5D18	-9181.0
OR52J3	-9141.0
OR51B4	-9099.0
OR6M1	-9085.0
OR7G2	-9081.0
OR7E24	-9052.0
OR4A5	-9032.0
OR8B4	-9028.0
OR4F15	-9021.0
OR51D1	-9001.0
OR9I1	-8995.0
OR7G3	-8989.0
OR13C4	-8947.0
OR11A1	-8928.0
OR9G4	-8918.0
OR6C74	-8907.0
OR52I1	-8898.0
OR2M4	-8877.0
OR1L3	-8872.0
OR5M8	-8806.0
OR2G3	-8800.0
OR14A16	-8777.0
OR12D3	-8724.0
OR4D5	-8690.0
OR10G4	-8606.0
OR51I2	-8589.0
OR4X1	-8545.0
OR5H6	-8501.0
OR7D4	-8458.0
OR5M11	-8445.0
OR5AS1	-8402.0
OR2A12	-8353.0
OR8K1	-8346.0
OR6T1	-8331.0
OR4N2	-8280.0
OR9Q1	-8245.0
OR1L8	-8189.0
OR2T6	-8151.0
OR51B2	-8132.0
OR8D4	-8110.0
OR8U8	-8103.0
OR4E2	-8081.0
OR52N1	-8017.0
OR8B12	-7982.0
OR8K5	-7956.0
OR2F2	-7789.0
OR51F1	-7718.0
OR5AK2	-7678.0
OR8U3	-7669.0
OR8D1	-7626.0
OR8K3	-7610.0
OR6C68	-7456.0
OR13D1	-7437.0
OR1B1	-7301.0
OR6C65	-7219.0
OR56A3	-7182.0
OR9Q2	-7139.0
OR13C9	-7124.0
OR6F1	-7110.0
OR2K2	-7088.0
OR51A2	-7072.0
OR2H2	-6943.0
OR6B2	-6920.0
OR5L1	-6892.0
OR10A6	-6831.0
OR11L1	-6682.0
OR6P1	-6505.0
ANO2	-6297.0
OR2T8	-6208.0
EBF1	-6187.0
OR2A2	-6172.0
GNG13	-6148.0
OR5F1	-6009.0
OR1M1	-5979.0
OR51B6	-5909.0
OR8J1	-5740.0
OR2H1	-5650.0
OR8U1	-5631.0
OR5B12	-5609.0
OR2T3	-5604.0
OR1N1	-5591.0
OR4K1	-5447.0
OR51Q1	-5424.0
OR5M9	-5417.0
OR5K3	-5366.0
OR5K1	-5364.0
OR2C3	-5342.0
OR6C1	-5338.0
OR2Z1	-5296.0
OR13C2	-5219.0
OR10K1	-5131.0
OR10H2	-5107.0
OR8D2	-5098.0
OR52A5	-5085.0
OR8H3	-5063.0
OR5B3	-4984.0
OR4A16	-4980.0
OR2W3	-4962.0
RTP2	-4942.0
OR10S1	-4937.0
OR4C3	-4935.0
OR51L1	-4844.0
OR4D6	-4838.0
OR2C1	-4709.0
OR13G1	-4665.0
OR2Y1	-4609.0
OR52W1	-4508.0
OR51G1	-4506.0
OR8B2	-4484.0
OR5V1	-4473.0
OR2D3	-4425.0
OR8S1	-4284.0
OR5D14	-4098.0
OR5T1	-4021.0
OR13C3	-4007.0
OR1L1	-3994.0
OR51S1	-3964.0
OR1Q1	-3946.0
OR5H2	-3929.0
OR4F6	-3886.0
OR52B6	-3877.0
OR56A4	-3755.0
OR13F1	-3735.0
OR5AU1	-3535.0
OR4M1	-3504.0
OR52M1	-3456.0
OR51V1	-3408.0
OR51E2	-3373.0
OR1K1	-3348.0
OR51A7	-3177.0
OR1C1	-3171.0
OR2L2	-2975.0
REEP1	-2809.0
OR2F1	-2796.0
OR10A5	-2735.0
OR5AP2	-2656.0
OR7C2	-2555.0
OR5M1	-2449.0
OR9A4	-2336.0
OR6B1	-1919.0
OR2B2	-1824.0
OR4A47	-1774.0
OR6X1	-1697.0
OR9G1	-1653.5
OR9G9	-1653.5
OR7A17	-1605.0
OR6C76	-1603.0
OR4A15	-1380.0
OR5P2	-1293.0
OR7A10	-1250.0
OR10G2	-1224.0
OR4C6	-1051.0
OR2L13	-921.0
OR2B3	-853.0
OR2B11	-817.0
OR4K17	-797.0
OR2T1	-728.0
OR5W2	-636.0
OR10C1	-593.0
OR2T33	-569.0
OR4B1	19.0
OR10H4	41.0
LHX2	65.0
OR52I2	66.0
OR2AK2	69.0
OR2D2	238.0
OR2T27	284.0
OR5K4	322.0
OR6C4	329.0
OR5D13	396.0
OR5B2	581.0
OR5D16	593.0
OR52K1	636.0
OR51I1	690.0
OR1L4	972.0
OR51B5	1074.0
OR13C8	1129.0
OR10G3	1353.0
OR52H1	1399.0
OR4S1	1429.0
OR7D2	1712.0
GNB1	1912.0
CNGA4	2089.0
OR52B2	2267.0
OR10H5	2336.0
OR5T2	2380.0
OR10Q1	2522.0
OR2M2	2524.0
OR1G1	2609.0
OR52E8	2695.0
OR1L6	2710.0
OR6C70	2713.0
CNGB1	2821.0
OR10A2	2847.0
OR1J4	3050.0
RTP1	3070.0
OR4C15	3218.0
OR8H1	3349.0
OR9A2	3532.0
OR52R1	3558.0
OR1E2	3744.0
OR1D2	3751.0
OR10J1	3792.0
OR1S1	3841.0
OR6K3	3895.0
OR5AN1	3940.0
OR52N2	3946.0
OR12D2	3953.0
OR2A14	3990.0
OR1E1	4198.0
OR5H1	4201.0
OR9K2	4211.0
OR5L2	4250.0
OR52A1	4401.0
OR4C46	4521.0
OR6C6	4770.0
OR11G2	5195.0
OR8B8	5235.0
OR3A3	5264.0
OR2AG1	5329.0
OR1A2	5336.0
GNAL	5358.0
OR2T11	5399.0
OR5AR1	5631.0
OR5K2	5673.0
OR6C75	5703.0
OR4N5	5708.0
OR8G1	5757.0
OR4K2	5850.0
OR10X1	5891.0
OR2AP1	5967.0
OR7G1	5974.0
OR3A2	5991.0
OR8A1	6187.0
OR2L8	6353.0
ADCY3	6370.0
OR1N2	6676.0
OR6K2	6718.0
OR14C36	6790.0
OR2J2	6849.0
OR6K6	6883.0
OR6Y1	7007.0
OR51G2	7115.0
OR51M1	7218.0
OR1J2	7293.0
OR10Z1	7611.0
OR2A5	7635.0
OR4L1	7651.0
OR10H1	7697.0
OR1I1	7879.0
OR11H6	7978.0
OR10W1	8174.0
LDB1	8308.0
OR52D1	8394.0
OR2W1	8523.0
OR6C3	8682.0
OR13J1	8688.0
OR4X2	8978.0
OR4K5	9040.0
OR3A1	9127.0
OR6V1	9130.0
OR4C45	9176.0
OR2M7	9214.0
OR8J3	9246.0
OR10J5	9344.0
OR10G9	9390.0
OR13A1	9485.0
OR56A1	9563.0
OR56B1	9569.0
OR7A5	9645.0
OR6A2	9707.0
OR2M3	9859.0
OR10K2	10072.0
OR10V1	10090.0
OR4D10	10135.0
OR2L3	10144.0
OR4D2	10211.0
OR4C12	10313.0
OR1J1	10429.0
OR14I1	10571.0
OR6N2	10582.0
OR56A5	10645.0
OR2AE1	10656.0
OR2B6	10684.0
OR11H4	10714.0
OR52E2	10720.0
OR4D1	10778.0
OR10A7	10853.0
OR2T4	10920.0
OR5H15	10934.0
OR6C2	10990.0
OR10A4	11067.0
OR2G2	11166.0
OR2AG2	11198.0
OR6S1	11245.0
OR4K14	11340.0
OR2G6	11412.0
OR2M5	11516.0
OR2T12	11550.0
OR8G5	11592.0
OR10P1	11626.0
OR10T2	11732.0
OR4D9	11774.0

---

REACTOME_MRNA_SPLICING

REACTOME_MRNA_SPLICING

	1143
set	REACTOME_MRNA_SPLICING
setSize	197
pANOVA	3.66e-09
s.dist	0.244
p.adjustANOVA	1e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DDX39B	11243
TXNL4A	11060
AQR	10996
SF3B6	10955
SNRNP70	10869
SNRPC	10840
CWC25	10723
PHF5A	10688
SRRM1	10636
HNRNPL	10528
RBM22	10483
PRPF8	10442
SF3B4	10367
SNRNP27	10314
HNRNPK	10300
SNRPD2	10271
GTF2F1	10225
POLR2E	10170
SNRPF	10159
SF1	10096

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DDX39B	11243
TXNL4A	11060
AQR	10996
SF3B6	10955
SNRNP70	10869
SNRPC	10840
CWC25	10723
PHF5A	10688
SRRM1	10636
HNRNPL	10528
RBM22	10483
PRPF8	10442
SF3B4	10367
SNRNP27	10314
HNRNPK	10300
SNRPD2	10271
GTF2F1	10225
POLR2E	10170
SNRPF	10159
SF1	10096
PRPF18	9854
U2AF1L4	9713
FAM32A	9712
DDX42	9704
NCBP2	9630
HNRNPM	9623
SRRT	9591
RNPC3	9589
WBP4	9550
ISY1	9535
DDX5	9484
SF3B5	9442
NCBP1	9433
DHX8	9422
DNAJC8	9352
SRSF1	9323
YJU2	9024
SDE2	8942
GPATCH1	8758
POLR2D	8613
MAGOHB	8573
PUF60	8478
CDC40	8444
ZNF830	8437
BCAS2	8233
PPIG	8231
ZMAT5	8063
RBM42	8029
TCERG1	8023
PPP1R8	7934
SNRPB2	7928
PCBP2	7782
SNU13	7775
ZMAT2	7753
LENG1	7689
SMNDC1	7668
PCBP1	7569
DHX16	7471
PRPF38A	7395
RBM17	7389
USP39	7097
UBL5	7094
SNRPD1	7057
DHX38	7051
BUD31	7034
HNRNPF	6963
PPIL1	6953
FUS	6711
PPIE	6595
CWC22	6173
SF3A1	6031
PPIL2	5968
HNRNPA3	5950
PRPF31	5923
EFTUD2	5901
CDC5L	5869
SRSF12	5821
SF3A2	5798
HNRNPA2B1	5614
SYF2	5609
DDX23	5444
POLR2I	5240
PPWD1	5202
POLR2A	5042
SNRNP200	5003
TRA2B	5002
SNW1	4927
SUGP1	4734
SNRPA1	4531
SLU7	4525
SNRNP35	4449
SRSF3	4433
HNRNPD	4380
DHX35	4323
SF3A3	4277
DDX46	4257
POLR2F	4146
SRSF9	4130
TFIP11	4038
SNRPA	3859
SART1	3784
POLR2H	3756
SNRPD3	3720
SRSF6	3503
PTBP1	3420
WBP11	3381
PNN	3310
DHX9	3150
NSRP1	3053
HNRNPU	2870
LSM6	2858
CHERP	2852
SF3B2	2742
LSM5	2677
CCAR1	2582
ZCRB1	2379
PPIH	2293
SAP18	2286
PRPF4	2214
HSPA8	2120
LSM4	1925
LUC7L3	1917
RBM39	1886
GCFC2	1807
PRKRIP1	1536
SNRNP40	1428
RBM25	1372
CRNKL1	1295
POLR2B	1016
SRRM2	1013
PDCD7	996
SRSF2	951
SNIP1	816
PRPF40A	759
SRSF11	669
PPIL4	528
WDR70	500
LSM2	496
U2AF2	490
CASC3	449
ALYREF	429
SF3B1	262
BUD13	96
SRSF4	47
RBM8A	-178
RNPS1	-231
LSM7	-245
U2SURP	-322
POLR2G	-351
SNRPB	-401
PLRG1	-537
HNRNPR	-543
SF3B3	-785
POLR2K	-795
LSM8	-818
SNRPG	-949
LSM3	-972
CWC27	-1023
PPIL3	-1034
CACTIN	-1225
RBM5	-1483
POLR2C	-1547
MTREX	-1644
MAGOH	-1713
PRPF19	-1758
DDX41	-2007
SRSF5	-2055
HNRNPC	-2240
CWC15	-2330
SNRNP48	-2487
EIF4A3	-2617
GTF2F2	-3076
IK	-3135
PRCC	-3164
ACIN1	-3308
CWF19L2	-3618
CTNNBL1	-3709
XAB2	-3998
MFAP1	-4449
SRSF10	-4497
RBM7	-4612
HNRNPH1	-4659
HNRNPA1	-4801
SRSF7	-4925
SRSF8	-5041
DHX15	-5864
PRPF6	-6253
YBX1	-6440
SNRNP25	-6687
PRPF3	-6898
SMU1	-6901
SNRPE	-7134
SNRPN	-7665
POLR2L	-7683
C9orf78	-8096
CCDC12	-8221
POLR2J	-9382

---

REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

	1161
set	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION
setSize	1336
pANOVA	8.63e-09
s.dist	0.0938
p.adjustANOVA	2.02e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RETN	11771
CTLA4	11744
ZNF595	11723
RGCC	11573
SKIC8	11483
E2F4	11443
ZNF730	11374
KMT2B	11327
ZNF254	11273
DDB2	11268
ZNF586	11266
DDX39B	11243
CDKN2B	11226
NR1I3	11225
H2AC14	11207
ZNF506	11177
RFFL	11154
PSMD3	11142
HDAC5	11105
TRIM28	11100

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RETN	11771.0
CTLA4	11744.0
ZNF595	11723.0
RGCC	11573.0
SKIC8	11483.0
E2F4	11443.0
ZNF730	11374.0
KMT2B	11327.0
ZNF254	11273.0
DDB2	11268.0
ZNF586	11266.0
DDX39B	11243.0
CDKN2B	11226.0
NR1I3	11225.0
H2AC14	11207.0
ZNF506	11177.0
RFFL	11154.0
PSMD3	11142.0
HDAC5	11105.0
TRIM28	11100.0
CGB8	11085.0
SARNP	11065.0
SOX9	11050.0
ZNF337	11040.0
RORC	11033.0
ZNF782	11016.0
COX5A	10947.0
ZNF860	10900.0
ZNF577	10860.0
TCEA1	10805.0
POU4F2	10799.0
SMARCA4	10798.0
ZNF543	10757.0
RUNX3	10738.0
TGIF2	10737.0
ZNF585B	10694.0
ZSCAN25	10691.0
H2BC3	10676.0
DAXX	10654.0
SRRM1	10636.0
H3C3	10604.0
TCF7	10592.0
ZNF724	10589.0
PRMT5	10556.0
TNRC6C	10537.0
ZNF589	10494.0
USP2	10472.0
CPSF1	10424.0
PSMC1	10399.0
HDAC10	10397.0
RNF34	10341.0
UBE2I	10324.0
NELFB	10298.0
COX7A2L	10235.0
PCNA	10230.0
BCL2L11	10226.0
GTF2F1	10225.0
MEAF6	10219.0
SST	10217.0
SOX2	10212.0
ZNF253	10204.0
H3C8	10202.0
KCTD6	10198.0
BID	10197.0
PSMB1	10173.0
POLR2E	10170.0
UBA52	10169.0
SNRPF	10159.0
MAPK14	10146.0
ABCA6	10126.0
PDPK1	10091.0
ATXN3	10084.0
ATR	10067.0
CDK13	10057.0
MGA	10045.0
TAF15	10036.0
ZNF70	10032.0
GTF2H5	10024.0
ZNF564	10022.0
ZNF773	10009.0
TAF12	10008.0
NOP2	10004.0
SREBF1	9995.0
POU2F2	9987.0
MED17	9911.0
ZNF761	9906.0
PSMC6	9892.0
ZNF302	9879.0
INTS2	9869.0
ZNF701	9853.0
SMURF2	9848.0
ZNF17	9843.0
CDC23	9833.0
TCF3	9790.0
CEBPB	9779.0
CAMK2G	9730.0
JUN	9721.0
U2AF1L4	9713.0
XPO1	9708.0
ZKSCAN4	9705.0
SUPT5H	9702.0
SMAD2	9684.0
ZNF250	9679.0
KCTD15	9675.0
ZNF486	9665.0
ZNF700	9657.0
NCBP2	9630.0
LAMTOR4	9628.0
ZNF675	9606.0
NPPA	9597.0
SRRT	9591.0
PRKAA1	9578.0
SETD9	9577.0
ZNF570	9576.0
LEF1	9560.0
ZNF266	9557.0
ZNF614	9555.0
TP53	9551.0
ZNF551	9544.0
H2BC14	9533.0
NR2E1	9525.0
BTG1	9521.0
ZKSCAN8	9513.0
MED16	9508.0
PPP1R13L	9498.0
CCNB1	9488.0
ITGA2B	9472.0
COX14	9444.0
CCNG2	9441.0
NCBP1	9433.0
NFYB	9420.0
ZNF718	9393.0
MED26	9384.0
ZNF184	9349.0
ZNF668	9341.0
ZNF468	9340.0
ELF2	9324.0
SRSF1	9323.0
RMI1	9316.0
ZNF791	9295.0
COX4I1	9285.0
NR2F1	9283.0
HAND2	9273.0
ZNF416	9263.0
H4C16	9262.0
RBM14	9254.0
H4C11	9253.0
ZNF460	9250.0
TEAD4	9240.0
PSMD4	9234.0
ZNF286A	9231.0
ZNF559	9230.0
CSNK2A1	9219.0
COX6B1	9199.0
CCNC	9187.0
SIN3A	9180.0
ZNF485	9171.0
BRPF1	9147.0
RPRD2	9134.0
RPA3	9109.0
ELF1	9105.0
RAD9B	9100.0
ZNF213	9080.0
PTPN1	9077.0
ZNF19	9068.0
H4C8	9007.0
ZNF14	8970.0
RPAP2	8969.0
NELFCD	8950.0
GATAD2B	8932.0
INTS10	8918.0
DNA2	8886.0
GTF2H1	8877.0
PAF1	8840.0
ZNF714	8819.0
FOS	8811.0
YWHAB	8801.0
MLLT1	8776.0
TFDP2	8771.0
MED4	8770.0
CPSF6	8756.0
H2AZ1	8737.0
ZNF688	8733.0
PSME3	8732.0
CTDP1	8731.0
ZNF211	8678.0
HDAC3	8661.0
RNU11	8659.0
PMS2	8648.0
BIRC5	8644.0
RELA	8623.0
SETD1B	8620.0
RAD9A	8617.0
POLR2D	8613.0
PIP4P1	8609.0
GLS2	8596.0
ZNF160	8579.0
MAGOHB	8573.0
GTF2H3	8555.0
INTS4	8548.0
ZNF101	8533.0
CREBBP	8505.0
NR1D2	8491.0
HIPK1	8483.0
CDK12	8470.0
CDC40	8444.0
CHD3	8412.0
H2AC8	8407.0
ANAPC10	8406.0
DLX5	8402.0
PSMD13	8389.0
STK11	8335.0
ZNF707	8319.0
LDB1	8308.0
ZKSCAN1	8291.0
SMARCC1	8285.0
RRAGA	8261.0
E2F1	8248.0
NDUFA4	8243.0
CHD4	8242.0
ZC3H8	8241.0
INTS12	8217.0
REST	8214.0
YWHAZ	8195.0
SMARCB1	8185.0
ZNF334	8184.0
MED13	8167.0
RPA1	8165.0
ZNF490	8161.0
SMARCC2	8155.0
CSTF2T	8143.0
TIGAR	8107.0
RBBP5	8079.0
ZFP14	8070.0
SNAPC5	8064.0
SNAPC1	8028.0
PMAIP1	7972.0
PRKACA	7965.0
POU4F1	7961.0
PSMC3	7956.0
RRAGD	7937.0
RORB	7935.0
ZNF546	7912.0
ELOA	7897.0
MAX	7890.0
CYCS	7886.0
NOC2L	7862.0
GTF2E1	7861.0
INTS3	7842.0
BRD2	7810.0
FASLG	7809.0
HEY2	7797.0
WRN	7786.0
PIP4K2B	7785.0
ZNF776	7780.0
H4C5	7742.0
PBRM1	7734.0
CENPJ	7729.0
PPARD	7722.0
PSMA3	7703.0
HDAC1	7688.0
SUPT6H	7655.0
ZNF12	7643.0
TBX5	7626.0
TRIM33	7609.0
CBX3	7599.0
KMT2D	7592.0
CDK4	7586.0
ZNF333	7583.0
CITED2	7561.0
ZNF433	7554.0
TBP	7543.0
UCMA	7535.0
ZNF432	7525.0
CAT	7524.0
ZNF770	7519.0
H2BC10	7509.0
RAD50	7503.0
CARM1	7482.0
PCF11	7470.0
ZNF37A	7462.0
INTS1	7461.0
CHEK1	7457.0
PIDD1	7409.0
COX6A1	7404.0
APAF1	7377.0
TFAP2A	7347.0
PSMD7	7334.0
CPSF4	7318.0
CREB1	7306.0
SIRT1	7303.0
STAT1	7294.0
MED23	7243.0
PARP1	7236.0
MED1	7212.0
FBXW7	7200.0
SSU72	7189.0
DDIT3	7173.0
ZNF671	7170.0
TRIM63	7155.0
RARG	7122.0
RNF2	7121.0
USP7	7118.0
LEO1	7116.0
ZNF274	7114.0
G6PC1	7106.0
FANCD2	7092.0
ZNF569	7084.0
KMT2A	7072.0
THOC1	7060.0
CPSF7	7056.0
DLX6	7052.0
DHX38	7051.0
BCL2L14	7043.0
MED15	7037.0
ZNF420	7024.0
IL2RA	7014.0
AGO1	6991.0
ITGAL	6976.0
TAF9	6942.0
ACTL6A	6941.0
PF4	6931.0
PSMA7	6898.0
H4C3	6897.0
ZNF611	6866.0
PSMA1	6861.0
ZNF565	6827.0
ZNF225	6800.0
TOP3A	6789.0
ZFPM1	6763.0
ZNF706	6758.0
RNMT	6733.0
NUDT21	6723.0
CSTF3	6719.0
INTS14	6715.0
PPARA	6700.0
RRM2	6698.0
TACO1	6680.0
DDIT4	6677.0
TP53AIP1	6636.0
INTS6	6632.0
ZNF557	6628.0
GPX2	6622.0
NFKB1	6611.0
AKT1	6607.0
ZNF740	6594.0
BNIP3L	6593.0
CDC25C	6560.0
MED27	6557.0
PSMB2	6549.0
PML	6494.0
ZNF28	6485.0
PSMC4	6484.0
ZNF429	6482.0
CSTF1	6481.0
ATM	6477.0
NR5A2	6463.0
FIP1L1	6458.0
HDAC2	6444.0
NFYA	6428.0
GADD45A	6427.0
EPC1	6402.0
UBB	6377.0
WDR33	6333.0
CDC16	6332.0
PPM1D	6330.0
AGO2	6315.0
CDK1	6313.0
CPSF2	6288.0
GATA4	6287.0
NR1I2	6283.0
ZNF613	6273.0
IFNG	6252.0
PSMD9	6250.0
LAMTOR5	6246.0
E2F8	6237.0
MED24	6232.0
ZNF548	6210.0
SLC2A3	6208.0
NOTCH2	6202.0
SRC	6197.0
TRPC3	6183.0
CBX8	6182.0
TFDP1	6154.0
TRIAP1	6140.0
TNRC6B	6127.0
SKP2	6108.0
ZNF227	6094.0
NCOR1	6071.0
ITCH	6063.0
PAPOLA	6042.0
ZNF136	6016.0
POMC	6010.0
TEAD3	5990.0
WDR5	5961.0
PSMD14	5956.0
MYC	5940.0
SMAD7	5937.0
OPRM1	5936.0
ZNF624	5917.0
CTNNB1	5893.0
ZNF195	5889.0
AKT2	5870.0
ATAD2	5852.0
ESR2	5832.0
ZKSCAN5	5809.0
ESRRA	5788.0
RBX1	5779.0
H4C9	5774.0
PSMA6	5773.0
NR1H2	5767.0
COX5B	5725.0
GATAD2A	5722.0
RB1	5689.0
EP300	5668.0
PTPN11	5640.0
ZFP69B	5632.0
ZNF282	5623.0
ARNT	5594.0
ZNF324	5553.0
ATF2	5532.0
CCNT1	5525.0
LSM10	5521.0
ARID3A	5493.0
ZNF563	5465.0
ZNF354B	5461.0
EAF1	5460.0
ZNF664	5437.0
NELFE	5395.0
ZNF180	5394.0
CBFB	5386.0
PSME2	5380.0
SETD1A	5361.0
PSMD11	5320.0
SMAD4	5313.0
KRBOX5	5301.0
ZNF264	5281.0
UBE2S	5276.0
COX8A	5268.0
ZNF418	5244.0
POLR2I	5240.0
CBX4	5225.0
SUPT4H1	5215.0
CHEK2	5205.0
PHF20	5189.0
ZNF749	5187.0
CDC26	5157.0
ELL3	5132.0
H2AC18	5121.5
H2AC19	5121.5
RFC2	5115.0
ZNF43	5107.0
ANAPC1	5092.0
THOC6	5090.0
JUNB	5088.0
CDKN1B	5083.0
EED	5078.0
THOC5	5071.0
H2BC8	5070.0
PSMB5	5052.0
POLR2A	5042.0
CALM1	5021.0
ELOB	5019.0
ZNF721	4993.0
ZNF709	4957.0
SNW1	4927.0
BANP	4905.0
PPP1R13B	4877.0
ZNF114	4861.0
ZSCAN32	4848.0
PSMB3	4835.0
SCMH1	4833.0
TFAP2D	4827.0
PPP2R1B	4800.0
ZNF215	4781.0
KDM5B	4754.0
SUPT16H	4733.0
CAMK4	4719.0
SLBP	4710.0
AGO3	4706.0
ZNF25	4699.0
ZNF750	4684.0
SKI	4679.0
ZNF354A	4672.0
FBXO32	4667.0
ZC3H11A	4653.0
FYTTD1	4619.0
MSTN	4615.0
PHAX	4608.0
ZNF324B	4597.0
SP1	4581.0
PRDX2	4555.0
FANCI	4548.0
VDR	4546.0
SLU7	4525.0
KAT2A	4523.0
RPRD1B	4522.0
NR5A1	4492.0
ZNF764	4485.0
RPA2	4484.0
JAG1	4477.0
RBL2	4475.0
ZNF708	4466.0
ZNF30	4465.0
AURKB	4455.0
PRKAG3	4451.0
NELFA	4446.0
NOTCH4	4439.0
IWS1	4436.0
SRSF3	4433.0
RRAGC	4408.0
PITX2	4405.0
TFAP2B	4362.0
CDK8	4344.0
RHEB	4311.0
CNOT11	4259.0
BMP2	4255.0
PRELID1	4226.0
PGR	4206.0
ZNF552	4191.0
CAMK2B	4182.0
PSME4	4171.0
CASP2	4166.0
H3C1	4153.0
ZNF669	4150.0
POLR2F	4146.0
SRSF9	4130.0
BAX	4105.0
PPP2R5C	4099.0
COX16	4096.0
ING2	4091.0
CNOT2	4080.0
H3-3A	4052.0
MDM2	4051.0
ZNF655	4047.0
H2BC11	4044.0
UBE2D3	4033.0
RABGGTB	4023.0
GSK3B	4021.0
PRKAB1	3970.0
ZNF394	3965.0
SNAPC2	3959.0
ZFP69	3954.0
PLK2	3943.0
SLC38A9	3942.0
ELOC	3936.0
PSMD12	3928.0
MAP2K6	3919.0
ZNF311	3912.0
TOPBP1	3907.0
RBBP4	3906.0
CNOT1	3890.0
CCNE2	3867.0
CDKN2A	3849.0
RAD17	3845.0
TAF2	3833.0
ANAPC7	3809.0
IHH	3787.0
NRBP1	3785.0
CSNK2B	3763.0
TNFRSF10B	3762.0
CAV1	3760.0
POLR2H	3756.0
CNOT3	3742.0
COX7C	3738.0
PRMT1	3725.0
ZNF775	3724.0
SNRPD3	3720.0
HIPK2	3717.0
PSMD5	3711.0
RBPJ	3704.0
YAP1	3699.0
PSMB8	3681.0
RTF1	3666.0
MAML3	3654.0
ZNF235	3653.0
PSMA4	3640.0
INS	3627.0
MBD3	3615.0
RARA	3613.0
TSC2	3609.0
SCO1	3592.0
NBN	3589.0
ZNF92	3577.0
HDAC4	3576.0
RFC4	3563.0
MDC1	3549.0
SRSF6	3503.0
ZNF140	3497.0
ZNF287	3492.0
SESN3	3469.0
ZNF226	3414.0
PCBP4	3406.0
ANAPC5	3355.0
FZR1	3328.0
ZNF212	3326.0
MYB	3324.0
ZNF774	3323.0
COX11	3319.0
ANAPC4	3312.0
CDK7	3307.0
GAMT	3294.0
GTF2A1	3275.0
ZNF670	3236.0
ZNF587	3223.0
RXRB	3213.0
KMT2C	3189.0
PRKCB	3154.0
H3C6	3151.0
CDC73	3140.0
LGALS3	3113.0
LAMTOR3	3112.0
ZNF697	3095.0
ZNF74	3088.0
H2AX	3086.0
L3MBTL2	3084.0
SMARCD1	3080.0
PSMD1	3063.0
DYRK2	3062.0
ZNF233	3054.0
ZNF680	3036.0
ZNF582	2989.0
FOXG1	2959.0
BRD7	2958.0
ZNF197	2950.0
AURKA	2948.0
LAMTOR2	2942.0
NOTCH1	2914.0
RPTOR	2905.0
ZNF2	2811.0
ZNF710	2794.0
ZNF500	2788.0
PIN1	2737.0
ZNF431	2723.0
CDC27	2701.0
SP7	2698.0
ZNF34	2683.0
NFYC	2680.0
MED20	2667.0
DGCR8	2651.0
SATB2	2643.0
DLL1	2611.0
CNOT4	2602.0
ARID2	2584.0
HDAC11	2567.0
HSPD1	2554.0
INTS8	2541.0
ZNF248	2531.0
CTR9	2523.0
PRKCQ	2519.0
POU2F1	2493.0
NR3C1	2470.0
NR2C2	2439.0
NR2C1	2430.0
RFC3	2420.0
KCTD1	2407.0
SMAD6	2399.0
SMARCE1	2388.0
ZNF605	2349.0
SSRP1	2333.0
RICTOR	2329.0
PSMB9	2322.0
ZNF547	2303.0
ZNF143	2302.0
H4C1	2273.0
ZNF696	2262.0
TNFRSF10A	2222.0
APOE	2205.0
ZNF529	2153.0
MAPK11	2152.0
ZNF221	2094.0
CTSK	2090.0
CNOT9	2082.0
MAPK3	2077.0
ZNF100	2071.0
ZNF200	2064.0
MAPKAP1	2024.0
ZNF267	2021.0
SESN1	2010.0
BRPF3	2008.0
ZNF268	1990.0
ANAPC2	1989.0
ZNF493	1982.0
SMYD2	1940.0
HEY1	1919.0
ZFP90	1875.0
CCNA2	1874.0
EAF2	1848.0
CCND1	1840.0
ZNF257	1831.0
NAMPT	1810.0
NR4A2	1800.0
ZNF556	1775.0
NPAS4	1753.0
RMI2	1748.0
TCF7L1	1734.0
ZNF443	1730.0
MDM4	1716.0
ZNF620	1692.0
MED31	1680.0
ZNF678	1673.0
PTPN4	1641.0
YWHAH	1632.0
ARID1B	1602.0
PTEN	1587.0
WWP1	1551.0
COL1A1	1543.0
BDNF	1541.0
EHMT2	1533.0
PSMC5	1519.0
H2AC6	1509.0
ZNF304	1496.0
BMI1	1490.0
ZNF566	1476.0
BRCA1	1471.0
SKP1	1470.0
MAML1	1461.0
SMARCD3	1435.0
H4C4	1434.0
IQSEC3	1423.0
BBC3	1421.0
RBL1	1386.0
UBE2D1	1355.0
PPP2CA	1345.0
INTS7	1332.0
ZNF385A	1287.0
PPM1A	1263.0
GTF2E2	1248.0
MTOR	1229.0
RBBP8	1178.0
AGO4	1166.0
THOC7	1161.0
ZNF571	1149.0
PRDX5	1143.0
ZNF792	1142.0
YWHAQ	1114.0
MNAT1	1066.0
GTF2H4	1040.0
INTS13	1036.0
ZNF561	1018.0
POLR2B	1016.0
H3C2	1002.0
CNOT7	961.0
ZNF568	955.0
HNF4A	953.0
SRSF2	951.0
AXIN1	936.0
MAPK1	915.0
PPARGC1B	912.0
ZNF573	895.0
PRKAG1	875.0
H3-3B	859.0
PPP2R1A	849.0
TP73	845.0
ING5	838.0
ZNF786	822.0
HES1	805.0
ZNF615	790.0
TAF3	788.0
ZNF641	786.0
GAD2	782.0
FOXO3	729.0
CSNK2A2	723.0
MED25	704.0
TGFB1	696.0
ZNF627	691.0
SRSF11	669.0
ZNF133	663.0
TBL1XR1	644.0
VEGFA	633.0
PRMT6	602.0
ZNF398	590.0
ZNF430	552.0
U2AF2	490.0
ZNF689	489.0
PABPN1	485.0
ZFP1	475.0
MOBP	461.0
CASC3	449.0
NDRG1	444.0
TAF13	443.0
LRPPRC	440.0
ALYREF	429.0
PRKAG2	412.0
CDC7	394.0
CNOT10	382.0
GPI	353.0
SUZ12	349.0
TXNRD1	268.0
MAF	261.0
ZNF202	243.0
NOTCH3	227.0
KMT5A	190.0
ARID1A	189.0
ZNF20	168.0
LSM11	159.0
KMT2E	148.0
GPRIN1	121.0
GEM	111.0
SNAPC3	104.0
ZNF484	91.0
ZNF350	88.0
JMY	49.0
SRSF4	47.0
PSMF1	4.0
TAF10	-28.0
CCN2	-37.0
SIN3B	-46.0
ZNF530	-59.0
MIR132	-73.0
NR0B2	-85.0
ASH2L	-118.0
ZNF567	-126.0
ZNF660	-132.0
ZNF554	-152.0
RAD51	-172.0
RBM8A	-178.0
H2BC1	-192.0
ZNF343	-196.0
PLAGL1	-215.0
RNPS1	-231.0
ZNF33A	-235.0
BLK	-243.0
ZNF726	-244.0
H2BC4	-260.0
MYBL2	-268.0
ZNF616	-270.0
ZNF771	-273.0
EHMT1	-280.0
EXO1	-290.0
THRA	-326.0
GLS	-334.0
EZH2	-344.0
POLR2G	-351.0
H2BC5	-354.0
RPRD1A	-362.0
ZNF175	-369.0
MRE11	-382.0
ICE1	-395.0
SNRPB	-401.0
ERBB2	-402.0
RAD1	-410.0
SEM1	-434.0
BRD1	-440.0
ZNF496	-450.0
TAF4	-484.0
ZNF778	-493.0
ITGA4	-497.0
INTS5	-507.0
MEN1	-532.0
INTS11	-563.0
ZNF473	-566.0
PRDM7	-611.0
CCND3	-628.0
ZFHX3	-631.0
POLDIP3	-663.0
ZNF626	-665.0
LBR	-679.0
PRDM1	-686.0
HTT	-717.0
RRM2B	-724.0
IGFBP3	-725.0
MED8	-727.0
GPAM	-733.0
ELL	-755.0
ZNF777	-761.0
SIRT3	-779.0
KRBA1	-780.0
OCLN	-784.0
CNOT8	-790.0
ZNF746	-791.0
POLR2K	-795.0
PSMC2	-844.0
SMARCA2	-856.0
ZNF141	-884.0
MSH2	-904.0
NABP2	-909.0
TGIF1	-929.0
SOCS4	-945.0
SNRPG	-949.0
ZNF555	-960.0
E2F6	-962.0
PRELID3A	-984.0
SRF	-991.0
PRDX1	-1010.0
ZNF549	-1016.0
YY1	-1037.0
GAD1	-1063.0
CRH	-1087.0
TAF5	-1088.0
DPY30	-1108.0
CDK6	-1114.0
ZNF737	-1120.0
PRR5	-1177.0
ZNF585A	-1212.0
MYL9	-1229.0
RNF111	-1255.0
NKX2-5	-1266.0
HUS1	-1275.0
ICE2	-1283.0
KAT6A	-1324.0
PIP4K2C	-1350.0
CCNK	-1375.0
COX18	-1408.0
ZNF470	-1416.0
CCNT2	-1429.0
ZNF256	-1449.0
ZNF425	-1451.0
YWHAG	-1477.0
COX19	-1493.0
TWIST1	-1501.0
ZNF528	-1504.0
POLR2C	-1547.0
PERP	-1563.0
COL1A2	-1569.0
AKT3	-1580.0
PRKAB2	-1585.0
ZNF234	-1589.0
ZNF772	-1595.0
ZNF154	-1606.0
TNFRSF10D	-1621.0
SUMO1	-1643.0
H3C11	-1655.0
PLXNA4	-1660.0
SERPINE1	-1662.0
NABP1	-1670.0
NPY	-1705.0
CGA	-1710.0
MAGOH	-1713.0
MED6	-1727.0
H4C12	-1743.0
ZNF417	-1770.0
H2BC12	-1772.0
NR2F6	-1784.0
SESN2	-1789.0
ZNF729	-1800.0
GTF2A2	-1840.0
RSPO3	-1855.0
ZNF317	-1867.0
MED30	-1873.0
ZNF713	-1875.0
ZNF415	-1884.0
ABL1	-1929.0
MAPKAPK5	-1948.0
BLM	-1963.0
E2F7	-1999.0
H2BC17	-2040.0
SMURF1	-2045.0
SURF1	-2049.0
SRSF5	-2055.0
CTSV	-2071.0
MLST8	-2078.0
TTC5	-2091.0
PINK1	-2102.0
TNRC6A	-2107.0
MET	-2113.0
TAF4B	-2117.0
H2BC21	-2129.0
ZNF3	-2130.0
ZNF479	-2148.0
ZFP2	-2150.0
INTS9	-2153.0
BARD1	-2156.0
FKBP5	-2158.0
PSMD6	-2201.0
YAF2	-2236.0
CDKN1A	-2242.0
MAML2	-2253.0
PAX5	-2258.0
GPS2	-2268.0
PSMD8	-2294.0
GATA2	-2298.0
LIFR	-2303.0
CDK5	-2315.0
E2F5	-2329.0
YES1	-2333.0
ZNF560	-2362.0
CDK5R1	-2377.0
TFAP2E	-2385.0
ZNF510	-2402.0
MLH1	-2409.0
ZNF599	-2433.0
SMARCD2	-2447.0
ZNF684	-2460.0
RPS27A	-2472.0
GCK	-2478.0
PHC3	-2479.0
ZNF26	-2490.0
KCNIP3	-2491.0
DDX39A	-2492.0
NR6A1	-2496.0
DEK	-2520.0
SOD2	-2532.0
ZNF704	-2545.0
TP53RK	-2553.0
RBFOX3	-2583.0
TCF12	-2614.0
EIF4A3	-2617.0
ARNT2	-2619.0
ANAPC11	-2624.0
RXRG	-2625.0
RHNO1	-2686.0
TEAD1	-2689.0
PSMA2	-2726.0
PCGF6	-2734.0
H4C13	-2741.0
ZNF23	-2779.0
GRIN2B	-2801.0
ZFP30	-2817.0
TFAP2C	-2934.0
ZNF426	-2962.0
ZNF607	-3014.0
ZNF440	-3037.0
ZNF716	-3050.0
GTF2F2	-3076.0
H2BC6	-3080.0
TP53INP1	-3087.0
NR2E3	-3134.0
H2BC15	-3142.0
PSMB4	-3191.0
TAF11	-3192.0
ZNF596	-3210.0
YWHAE	-3214.0
H2AC20	-3235.0
RING1	-3272.0
ZNF461	-3275.0
ZNF331	-3310.0
WWTR1	-3351.0
STUB1	-3378.0
H2AZ2	-3381.0
PLK3	-3410.0
ZNF682	-3418.0
ZNF738	-3424.0
NR1H3	-3438.0
ZNF692	-3450.0
PSMA8	-3478.0
ZNF169	-3483.0
ZNF584	-3600.0
ZNF790	-3622.0
KAT2B	-3652.0
NR1D1	-3664.0
CNOT6	-3666.0
TMEM219	-3691.0
TP53BP2	-3693.0
MED10	-3700.0
IL6	-3702.0
TPX2	-3710.0
CRADD	-3717.0
H2BC9	-3718.5
H3C7	-3718.5
GSR	-3723.0
ZNF799	-3724.0
MTA2	-3732.0
ZNF699	-3737.0
ELL2	-3785.0
AIFM2	-3793.0
ESR1	-3799.0
ZNF649	-3806.0
FAS	-3819.0
RUNX2	-3825.0
PPARG	-3832.0
RNGTT	-3846.0
RAD51D	-3866.0
YEATS4	-3918.0
MEF2C	-3930.0
ZNF540	-3932.0
PSMB10	-3966.0
ZNF703	-3977.0
TAF8	-3995.0
ANAPC16	-4002.0
CCNE1	-4003.0
ZNF436	-4025.0
RARB	-4041.0
CAMK2A	-4043.0
CASP6	-4088.0
LAMTOR1	-4126.0
LMO2	-4131.0
RFC5	-4136.0
ANAPC15	-4142.0
LMO1	-4145.0
PPARGC1A	-4177.0
AFF4	-4207.0
ZNF214	-4209.0
H2BC26	-4236.0
MSX2	-4238.0
BRIP1	-4248.0
ESRRB	-4250.0
NR3C2	-4264.0
ZNF793	-4269.0
PSMA5	-4274.0
ZNF138	-4275.0
RNU12	-4276.0
ZNF273	-4277.0
ZNF562	-4283.0
ZNF33B	-4325.0
TJP1	-4334.0
CTSL	-4367.0
ZKSCAN7	-4385.0
ZNF727	-4392.0
ZNF189	-4416.0
ZNF18	-4420.0
BMAL1	-4422.0
GTF2B	-4430.0
NR2C2AP	-4440.0
ZNF839	-4459.0
PHC2	-4460.0
PRKAA2	-4524.0
TCF7L2	-4535.0
CCNA1	-4580.0
ZNF230	-4606.0
KAT5	-4633.0
ZNF263	-4641.0
GRIA2	-4652.0
SFN	-4660.0
HIVEP3	-4671.0
ZNF625	-4682.0
ZNF224	-4695.0
GLI3	-4762.0
SPP1	-4765.0
PSMB6	-4786.0
MOV10	-4794.0
CHTOP	-4796.0
RYBP	-4848.0
ATRIP	-4882.0
SRSF7	-4925.0
L3MBTL1	-4987.0
TSC1	-4997.0
CPSF3	-5038.0
ZIK1	-5096.0
ZNF681	-5104.0
ACTL6B	-5120.0
ZNF205	-5129.0
ZNF606	-5141.0
TEAD2	-5149.0
ZNF483	-5192.0
ZNF662	-5209.0
NCOR2	-5218.0
ZNF691	-5237.0
PSMB7	-5258.0
CNOT6L	-5295.0
RET	-5314.0
ZNF480	-5317.0
TNFRSF10C	-5335.0
ZNF45	-5347.0
SKIL	-5359.0
ERCC3	-5361.0
UBE2C	-5371.0
CAMK2D	-5437.0
CDK9	-5440.0
TP53I3	-5473.0
TNKS1BP1	-5522.0
KLF4	-5540.0
IGFBP1	-5545.0
KIT	-5560.0
ZKSCAN3	-5595.0
WWOX	-5691.0
GRIN2A	-5734.0
PCGF2	-5737.0
CBX5	-5750.0
ZNF382	-5766.0
HDAC7	-5767.0
ERCC2	-5783.0
ZNF77	-5794.0
NR4A3	-5824.0
ZNF471	-5848.0
PVALB	-5897.0
NKX3-2	-5921.0
ZIM3	-5939.0
CBX6	-5952.0
FOXO1	-5960.0
CSF1R	-5990.0
BCL6	-6002.0
CR1	-6023.0
H2AJ	-6028.0
SYT10	-6033.0
ZNF519	-6040.0
NR1H4	-6111.0
SYMPK	-6153.0
RXRA	-6154.0
PPP2CB	-6157.0
SERPINB13	-6163.0
PSMD2	-6176.0
ZNF347	-6188.0
ZNF517	-6218.0
CITED4	-6228.0
COX20	-6251.0
ZNF804B	-6273.0
ZNF667	-6284.0
THOC3	-6299.0
CCNG1	-6312.0
SCO2	-6335.0
CUL1	-6388.0
CLP1	-6423.0
YBX1	-6440.0
H4C6	-6464.0
PIP4K2A	-6480.0
ZNF441	-6501.0
CLDN5	-6512.0
SGK1	-6558.0
VENTX	-6569.0
MLLT3	-6628.0
TWIST2	-6635.0
BTG2	-6659.0
CDK2	-6684.0
CASP1	-6717.0
ZNF445	-6720.0
ZNF521	-6736.0
ZNF544	-6743.0
ZNF583	-6745.0
NRBF2	-6776.0
TAF7	-6785.0
SMAD1	-6789.0
FANCC	-6835.0
MMP13	-6839.0
UBC	-6842.0
ZNF619	-6854.0
ZNF785	-6878.0
ZNF442	-6937.0
NPM1	-6941.0
ESRRG	-6972.0
TGFA	-6980.0
H4C2	-6995.0
RORA	-7027.0
OPRK1	-7068.0
SNRPE	-7134.0
ZNF79	-7160.0
ZNF665	-7166.0
PCGF5	-7178.0
ZNF222	-7188.0
ZNF419	-7233.0
CCND2	-7243.0
HDAC9	-7248.0
RUNX1	-7252.0
RBFOX1	-7259.0
IL2	-7294.0
RABGGTA	-7330.0
ZNF446	-7381.0
STEAP3	-7393.0
ZNF71	-7417.0
THBS1	-7436.0
MED7	-7449.0
ZNF610	-7465.0
GLI2	-7486.0
CBX2	-7506.0
ZNF112	-7513.0
ZNF135	-7535.0
CCNH	-7541.0
RNU4ATAC	-7544.0
TP63	-7582.0
UBE2E1	-7595.0
ZNF747	-7622.0
ZFP28	-7658.0
KRAS	-7660.0
POLR2L	-7683.0
ZNF658	-7690.0
ZNF736	-7699.0
CASP10	-7728.0
GATA3	-7751.0
AUTS2	-7762.0
PSME1	-7763.0
PCK1	-7816.0
ZNF514	-7829.0
MIR24-1	-7841.0
AGRP	-7863.0
ZNF223	-7888.0
ZNF677	-7892.0
ZNF875	-7912.0
ZNF558	-7916.0
NR4A1	-7934.0
ZNF600	-7942.0
EGFR	-7980.0
ZNF75A	-7981.0
ZNF354C	-7988.0
H3C4	-8000.0
ZNF454	-8046.0
TAF1L	-8088.0
ZNF320	-8101.0
ZIM2	-8121.0
H2AC4	-8140.0
COX6C	-8152.0
THRB	-8179.0
ITGBL1	-8197.0
H3C10	-8206.0
NEDD4L	-8238.0
TAL1	-8239.0
TXN	-8397.0
NFATC2	-8401.0
SNAPC4	-8413.0
ZNF208	-8415.0
ZNF155	-8423.0
ZNF99	-8425.0
ZNF439	-8428.0
MIR137	-8446.0
ZNF735	-8503.0
ZNF492	-8518.0
PSMB11	-8541.0
SMAD3	-8542.0
ZNF717	-8598.0
NUAK1	-8604.0
FOXO6	-8616.0
ZNF621	-8651.0
ZNF10	-8701.0
H2AC7	-8707.5
H2BC7	-8707.5
ZNF124	-8793.0
SPI1	-8820.0
HNF4G	-8897.0
ITGA5	-8904.0
SOCS3	-8908.0
FURIN	-8937.0
ZNF597	-8939.0
ZFP37	-8988.0
PHC1	-9004.0
ZNF550	-9013.0
H3C12	-9106.0
ZNF300	-9108.0
TAF6	-9176.0
ZNF676	-9212.0
H2BC13	-9329.0
POLR2J	-9382.0
NLRC4	-9452.0
GP1BA	-9470.0
ELOA2	-9527.0
TNFRSF18	-9578.0
NFE2	-9677.0
ZNF732	-9777.0
ZNF679	-9799.0
ZNF383	-9812.0
MIR27A	-9874.0
ZNF285	-9910.0
CGB5	-9962.0
MIR24-2	-10026.0
BGLAP	-10040.0
IL3	-10081.0
TXNIP	-10089.0
CSF2	-10097.0

---

REACTOME_CELL_CYCLE_MITOTIC

REACTOME_CELL_CYCLE_MITOTIC

	1112
set	REACTOME_CELL_CYCLE_MITOTIC
setSize	539
pANOVA	1.71e-08
s.dist	0.142
p.adjustANOVA	3.51e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MZT2A	11630
E2F4	11443
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
CDKN2B	11226
H2AC14	11207
DYNC1LI2	11173
PSMD3	11142
LIN37	11039
NUP37	10891
NSL1	10890
KIF23	10843
PPP2R5D	10754
H2BC3	10676
POLA2	10669
RCC2	10660
HAUS6	10657
H3C3	10604

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MZT2A	11630.0
E2F4	11443.0
TUBB8	11383.0
TUBB1	11311.0
DYNLL2	11280.0
MAPRE1	11267.0
CDKN2B	11226.0
H2AC14	11207.0
DYNC1LI2	11173.0
PSMD3	11142.0
LIN37	11039.0
NUP37	10891.0
NSL1	10890.0
KIF23	10843.0
PPP2R5D	10754.0
H2BC3	10676.0
POLA2	10669.0
RCC2	10660.0
HAUS6	10657.0
H3C3	10604.0
NCAPG	10503.0
SIRT2	10431.0
ANKLE2	10427.0
PSMC1	10399.0
HAUS8	10351.0
UBE2I	10324.0
TUBG1	10274.0
PCNA	10230.0
H3C8	10202.0
CCNB2	10190.0
CDKN2D	10181.0
PSMB1	10173.0
BTRC	10171.0
UBA52	10169.0
B9D2	10123.0
NUP85	10105.0
NUMA1	10088.0
PSMC6	9892.0
ZW10	9885.0
ORC1	9866.0
CDC23	9833.0
LMNA	9748.0
XPO1	9708.0
ORC6	9596.0
TP53	9551.0
H2BC14	9533.0
CCNB1	9488.0
RAB1A	9448.0
BUB1B	9436.0
CEP192	9411.0
RAB8A	9327.0
PPP2R5A	9306.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
CSNK2A1	9219.0
RPA3	9109.0
H4C8	9007.0
CEP250	9005.0
SEH1L	8981.0
FEN1	8951.0
POLE	8919.0
DNA2	8886.0
KPNB1	8882.0
TFDP2	8771.0
KIF20A	8767.0
H2AZ1	8737.0
PSME3	8732.0
CENPF	8713.0
BIRC5	8644.0
POLD1	8554.0
SFI1	8531.0
CTDNEP1	8494.0
TUBA1B	8427.0
H2AC8	8407.0
ANAPC10	8406.0
PSMD13	8389.0
KIF2A	8369.0
TUBGCP2	8356.0
NUP88	8287.0
NUP42	8255.0
E2F1	8248.0
RPA1	8165.0
CHMP7	8148.0
RPS27	8146.0
CDK11B	8099.0
PRIM1	7996.0
PCM1	7980.0
ZWILCH	7966.0
PRKACA	7965.0
TUBGCP6	7958.0
PSMC3	7956.0
NINL	7898.0
MAX	7890.0
CHMP4B	7852.0
GORASP2	7847.0
NUP62	7784.0
H4C5	7742.0
CENPJ	7729.0
PSMA3	7703.0
HDAC1	7688.0
DYNC1H1	7672.0
CEP76	7665.0
AKAP9	7637.0
CDK4	7586.0
CENPC	7578.0
KNL1	7549.0
H2BC10	7509.0
GINS2	7478.0
PHLDA1	7473.0
CCP110	7454.0
TPR	7435.0
TAOK1	7414.0
LIN52	7370.0
LEMD3	7365.0
PSMD7	7334.0
RANBP2	7289.0
PDS5A	7273.0
MCM5	7141.0
MASTL	7138.0
CEP152	7035.0
NUP93	6988.0
EML4	6970.0
PSMA7	6898.0
H4C3	6897.0
HAUS2	6862.0
PSMA1	6861.0
NUP214	6722.0
RRM2	6698.0
MAU2	6663.0
AKT1	6607.0
CDC25C	6560.0
PSMB2	6549.0
BANF1	6504.0
PSMC4	6484.0
KIF2C	6395.0
RAE1	6386.0
UBB	6377.0
MCM7	6360.0
CDC16	6332.0
CDK1	6313.0
CENPO	6310.0
CNTRL	6286.0
PCNT	6271.0
NUP153	6267.0
PSMD9	6250.0
TUBB4B	6227.0
SRC	6197.0
DCTN1	6189.0
CEP57	6168.0
TFDP1	6154.0
KIF18A	6129.0
SKP2	6108.0
DYRK1A	6100.0
NUP188	6088.0
TUBB2B	6024.0
PPP2R5B	6021.0
CENPK	6007.0
SMC2	6000.0
ITGB3BP	5989.0
PSMD14	5956.0
MYC	5940.0
MZT2B	5904.0
AKT2	5870.0
NUP54	5830.0
RBX1	5779.0
H4C9	5774.0
PSMA6	5773.0
RANGAP1	5723.0
HAUS5	5711.0
RB1	5689.0
EP300	5668.0
ESCO1	5626.0
PKMYT1	5593.0
CHMP2A	5566.0
ESCO2	5535.0
TUBG2	5534.0
CDCA5	5505.0
NUP133	5499.0
TUBA1A	5468.0
MCM8	5436.0
PSME2	5380.0
PSMD11	5320.0
UBE2S	5276.0
CSNK1D	5214.0
ARPP19	5206.0
TUBGCP3	5178.0
CDC26	5157.0
H2AC18	5121.5
H2AC19	5121.5
RFC2	5115.0
ANAPC1	5092.0
CDKN1B	5083.0
H2BC8	5070.0
PSMB5	5052.0
PLK4	5013.0
SPAST	4952.0
NUP58	4880.0
IST1	4868.0
PSMB3	4835.0
PPP2R1B	4800.0
LPIN3	4771.0
GINS1	4752.0
AAAS	4718.0
SDCCAG8	4662.0
CKS1B	4659.0
CENPP	4572.0
RPA2	4484.0
RBL2	4475.0
PPP1CB	4467.0
AURKB	4455.0
DYNC1LI1	4367.0
NUF2	4365.0
DCTN3	4358.0
NUP107	4332.0
LCMT1	4327.0
ORC4	4299.0
NDEL1	4296.0
NDC1	4258.0
PMF1	4252.0
PSME4	4171.0
H3C1	4153.0
MAD1L1	4118.0
PPP2R5C	4099.0
PPP1R12B	4074.0
H3-3A	4052.0
H2BC11	4044.0
GSK3B	4021.0
CEP41	3962.0
PSMD12	3928.0
RBBP4	3906.0
CCNE2	3867.0
CDKN2A	3849.0
ANAPC7	3809.0
TUBB3	3788.0
NEDD1	3782.0
CSNK2B	3763.0
CENPU	3739.0
PSMD5	3711.0
NCAPG2	3707.0
PSMB8	3681.0
PSMA4	3640.0
HMMR	3595.0
ORC2	3590.0
RFC4	3563.0
MIS12	3486.0
CHMP6	3463.0
RCC1	3413.0
ANAPC5	3355.0
FZR1	3328.0
ANAPC4	3312.0
CDK7	3307.0
INCENP	3298.0
MAD2L1	3280.0
BUB3	3260.0
MCM3	3239.0
STAG1	3161.0
PRKCB	3154.0
H3C6	3151.0
TOP2A	3104.0
H2AX	3086.0
PSMD1	3063.0
MZT1	3049.0
CEP43	3035.0
CC2D1B	2982.0
CDC25B	2961.0
AURKA	2948.0
ORC5	2938.0
CNEP1R1	2920.0
GMNN	2913.0
RAD21	2837.0
NUP43	2770.0
CKAP5	2726.0
RAB1B	2714.0
CDC27	2701.0
LPIN2	2646.0
HAUS4	2636.0
PPME1	2539.0
SMC3	2481.0
WEE1	2466.0
CLASP1	2462.0
NUP98	2445.0
RFC3	2420.0
GOLGA2	2395.0
NIPBL	2366.0
PPP2R5E	2327.0
PSMB9	2322.0
NCAPD3	2318.0
ALMS1	2281.0
PDS5B	2276.0
H4C1	2273.0
RFC1	2245.0
CDK11A	2235.0
VPS4A	2225.0
HSP90AB1	2115.0
MAPK3	2077.0
NUP160	2051.0
ZWINT	2046.0
ANAPC2	1989.0
NDC80	1973.0
DBF4	1954.0
NCAPD2	1923.0
CCNA2	1874.0
CCND1	1840.0
SSNA1	1783.0
KNTC1	1764.0
PLK1	1754.0
NEK6	1744.0
GTSE1	1709.0
GINS4	1702.0
CDCA8	1598.0
PPP2R2D	1578.0
DSN1	1571.0
PSMC5	1519.0
CDC6	1513.0
H2AC6	1509.0
TUBA8	1505.0
SKP1	1470.0
H4C4	1434.0
BUB1	1430.0
RBL1	1386.0
FBXO5	1384.0
UBE2D1	1355.0
PPP2CA	1345.0
ACTR1A	1341.0
CDC45	1297.0
PAFAH1B1	1262.0
POLE2	1257.0
LIG1	1254.0
FKBPL	1249.0
DHFR	1192.0
MNAT1	1066.0
H3C2	1002.0
JAK2	952.0
WAPL	929.0
MAPK1	915.0
FOXM1	905.0
ODF2	864.0
H3-3B	859.0
PPP2R1A	849.0
FBXL18	842.0
LIN54	826.0
ORC3	791.0
CSNK2A2	723.0
MCPH1	680.0
E2F2	656.0
NCAPH	632.0
DYNC1I2	583.0
LEMD2	434.0
CDC7	394.0
CEP290	370.0
SGO2	363.0
MCM2	327.0
LPIN1	305.0
TUBB6	295.0
CENPT	266.0
CENPL	253.0
CDC25A	220.0
KMT5A	190.0
CEP72	143.0
BORA	129.0
CEP70	10.0
PSMF1	4.0
CEP135	-44.0
TK1	-164.0
H2BC1	-192.0
H2BC4	-260.0
MYBL2	-268.0
CEP131	-335.0
H2BC5	-354.0
PPP1R12A	-430.0
SEM1	-434.0
TNPO1	-470.0
PRKCA	-589.0
CCND3	-628.0
VRK2	-660.0
LBR	-679.0
NUP35	-710.0
RAN	-745.0
SMC4	-771.0
PSMC2	-844.0
PRIM2	-897.0
CDT1	-944.0
E2F6	-962.0
CDC20	-1019.0
CDK6	-1114.0
CDKN2C	-1154.0
SGO1	-1205.0
CENPN	-1337.0
CLASP2	-1411.0
YWHAG	-1477.0
CENPQ	-1502.0
AKT3	-1580.0
SEC13	-1604.0
SUMO1	-1643.0
H3C11	-1655.0
H4C12	-1743.0
MCM4	-1749.0
H2BC12	-1772.0
CEP164	-1927.0
ABL1	-1929.0
NUDC	-1933.0
H2BC17	-2040.0
TMPO	-2048.0
PTTG1	-2073.0
H2BC21	-2129.0
MCM10	-2132.0
GORASP1	-2164.0
PSMD6	-2201.0
CDKN1A	-2242.0
FBXW11	-2247.0
PSMD8	-2294.0
ENSA	-2320.0
LYN	-2322.0
TUBA4A	-2325.0
E2F5	-2329.0
CEP78	-2378.0
TUBA4B	-2380.0
PPP2R2A	-2391.0
ESPL1	-2406.0
RPS27A	-2472.0
NEK7	-2483.0
USO1	-2498.0
ANAPC11	-2624.0
SKA1	-2643.0
PSMA2	-2726.0
CLIP1	-2732.0
H4C13	-2741.0
E2F3	-2835.0
BLZF1	-2904.0
AHCTF1	-2954.0
NUP205	-3003.0
CENPM	-3005.0
H2BC6	-3080.0
H2BC15	-3142.0
PSMB4	-3191.0
YWHAE	-3214.0
POLD3	-3223.0
H2AC20	-3235.0
NCAPH2	-3256.0
HSP90AA1	-3286.0
AJUBA	-3295.0
H3-4	-3300.0
PPP1CC	-3357.0
H2AZ2	-3381.0
PSMA8	-3478.0
CDK5RAP2	-3491.0
NUP50	-3509.0
CENPS	-3513.0
SKA2	-3548.0
PTK6	-3658.0
NDE1	-3667.0
NUP210	-3669.0
NEK9	-3707.0
TPX2	-3710.0
TUBGCP5	-3712.0
H2BC9	-3718.5
H3C7	-3718.5
LMNB1	-3736.0
CDKN1C	-3854.0
CHMP3	-3897.0
POM121	-3922.0
PSMB10	-3966.0
TUBA1C	-3972.0
HAUS1	-3989.0
ANAPC16	-4002.0
CCNE1	-4003.0
SET	-4012.0
RFC5	-4136.0
ANAPC15	-4142.0
H2BC26	-4236.0
MCM6	-4245.0
VRK1	-4259.0
PSMA5	-4274.0
TUBB	-4279.0
CDC14A	-4381.0
CCNA1	-4580.0
NME7	-4679.0
PSMB6	-4786.0
TUBGCP4	-4854.0
DYNLL1	-4954.0
POLE3	-4968.0
SPC25	-5044.0
CENPA	-5151.0
OPTN	-5157.0
PSMB7	-5258.0
DYNC1I1	-5309.0
HAUS3	-5315.0
DCTN2	-5318.0
UBE2C	-5371.0
POLD2	-5490.0
CHMP2B	-5574.0
CENPH	-5646.0
LIN9	-5919.0
NUP155	-5949.0
CHMP4A	-5994.0
PRKAR2B	-6011.0
H2AJ	-6028.0
TUBA3D	-6078.0
PPP2CB	-6157.0
PSMD2	-6176.0
POLD4	-6372.0
CUL1	-6388.0
H4C6	-6464.0
CDK2	-6684.0
SPC24	-6708.0
UBC	-6842.0
FBXL7	-6924.0
H4C2	-6995.0
TUBB4A	-7113.0
CENPE	-7223.0
CCND2	-7243.0
RAB2A	-7245.0
NEK2	-7458.0
CCNH	-7541.0
UBE2E1	-7595.0
TUBA3C	-7603.0
TYMS	-7748.0
PSME1	-7763.0
CEP63	-7908.0
H3C4	-8000.0
TUBB2A	-8021.0
POLE4	-8070.0
POM121C	-8073.0
H2AC4	-8140.0
H3C10	-8206.0
GINS3	-8210.0
PSMB11	-8541.0
H2AC7	-8707.5
H2BC7	-8707.5
TUBA3E	-8723.0
CABLES1	-8728.0
SPDL1	-8769.0
CSNK1E	-8775.0
TUBAL3	-9053.0
H3C12	-9106.0
H2BC13	-9329.0
CHMP4C	-9374.0
KIF2B	-9529.0

---

REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53

REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53

	591
set	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53
setSize	351
pANOVA	5.06e-08
s.dist	0.169
p.adjustANOVA	9.24e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RGCC	11573
E2F4	11443
DDB2	11268
RFFL	11154
COX5A	10947
TCEA1	10805
POU4F2	10799
DAXX	10654
PRMT5	10556
TNRC6C	10537
USP2	10472
RNF34	10341
NELFB	10298
COX7A2L	10235
PCNA	10230
GTF2F1	10225
MEAF6	10219
BID	10197
POLR2E	10170
UBA52	10169

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RGCC	11573
E2F4	11443
DDB2	11268
RFFL	11154
COX5A	10947
TCEA1	10805
POU4F2	10799
DAXX	10654
PRMT5	10556
TNRC6C	10537
USP2	10472
RNF34	10341
NELFB	10298
COX7A2L	10235
PCNA	10230
GTF2F1	10225
MEAF6	10219
BID	10197
POLR2E	10170
UBA52	10169
MAPK14	10146
PDPK1	10091
ATR	10067
CDK13	10057
TAF15	10036
GTF2H5	10024
TAF12	10008
JUN	9721
SUPT5H	9702
LAMTOR4	9628
PRKAA1	9578
SETD9	9577
TP53	9551
PPP1R13L	9498
CCNB1	9488
COX14	9444
RMI1	9316
COX4I1	9285
CSNK2A1	9219
COX6B1	9199
BRPF1	9147
RPA3	9109
RAD9B	9100
NELFCD	8950
GATAD2B	8932
DNA2	8886
GTF2H1	8877
FOS	8811
YWHAB	8801
TFDP2	8771
CTDP1	8731
PMS2	8648
BIRC5	8644
RAD9A	8617
POLR2D	8613
PIP4P1	8609
GLS2	8596
GTF2H3	8555
CREBBP	8505
HIPK1	8483
CDK12	8470
CHD3	8412
STK11	8335
RRAGA	8261
E2F1	8248
NDUFA4	8243
CHD4	8242
YWHAZ	8195
RPA1	8165
TIGAR	8107
PMAIP1	7972
POU4F1	7961
RRAGD	7937
ELOA	7897
CYCS	7886
NOC2L	7862
WRN	7786
PIP4K2B	7785
CENPJ	7729
HDAC1	7688
TBP	7543
RAD50	7503
CARM1	7482
CHEK1	7457
PIDD1	7409
COX6A1	7404
APAF1	7377
USP7	7118
FANCD2	7092
BCL2L14	7043
ZNF420	7024
AGO1	6991
TAF9	6942
TOP3A	6789
TACO1	6680
DDIT4	6677
TP53AIP1	6636
GPX2	6622
AKT1	6607
BNIP3L	6593
CDC25C	6560
PML	6494
ATM	6477
HDAC2	6444
GADD45A	6427
UBB	6377
AGO2	6315
CDK1	6313
LAMTOR5	6246
E2F8	6237
TFDP1	6154
TRIAP1	6140
TNRC6B	6127
AKT2	5870
COX5B	5725
GATAD2A	5722
EP300	5668
ATF2	5532
CCNT1	5525
ARID3A	5493
NELFE	5395
COX8A	5268
POLR2I	5240
SUPT4H1	5215
CHEK2	5205
PHF20	5189
RFC2	5115
CDKN1B	5083
POLR2A	5042
ELOB	5019
BANP	4905
PPP1R13B	4877
PPP2R1B	4800
SUPT16H	4733
AGO3	4706
PRDX2	4555
FANCI	4548
RPA2	4484
RBL2	4475
AURKB	4455
PRKAG3	4451
NELFA	4446
RRAGC	4408
RHEB	4311
CNOT11	4259
PRELID1	4226
CASP2	4166
POLR2F	4146
BAX	4105
PPP2R5C	4099
COX16	4096
ING2	4091
CNOT2	4080
MDM2	4051
RABGGTB	4023
PRKAB1	3970
PLK2	3943
SLC38A9	3942
ELOC	3936
MAP2K6	3919
TOPBP1	3907
RBBP4	3906
CNOT1	3890
CCNE2	3867
CDKN2A	3849
RAD17	3845
TAF2	3833
CSNK2B	3763
TNFRSF10B	3762
POLR2H	3756
CNOT3	3742
COX7C	3738
PRMT1	3725
HIPK2	3717
MBD3	3615
TSC2	3609
SCO1	3592
NBN	3589
RFC4	3563
MDC1	3549
SESN3	3469
PCBP4	3406
COX11	3319
CDK7	3307
LAMTOR3	3112
DYRK2	3062
BRD7	2958
AURKA	2948
LAMTOR2	2942
RPTOR	2905
PIN1	2737
CNOT4	2602
RFC3	2420
SSRP1	2333
RICTOR	2329
TNFRSF10A	2222
MAPK11	2152
CNOT9	2082
MAPKAP1	2024
SESN1	2010
BRPF3	2008
SMYD2	1940
CCNA2	1874
RMI2	1748
MDM4	1716
YWHAH	1632
PTEN	1587
EHMT2	1533
BRCA1	1471
BBC3	1421
RBL1	1386
PPP2CA	1345
ZNF385A	1287
MTOR	1229
RBBP8	1178
AGO4	1166
PRDX5	1143
YWHAQ	1114
MNAT1	1066
GTF2H4	1040
POLR2B	1016
CNOT7	961
PRKAG1	875
PPP2R1A	849
TP73	845
ING5	838
TAF3	788
CSNK2A2	723
NDRG1	444
TAF13	443
LRPPRC	440
PRKAG2	412
CNOT10	382
GPI	353
TXNRD1	268
KMT5A	190
JMY	49
TAF10	-28
PLAGL1	-215
EHMT1	-280
EXO1	-290
GLS	-334
POLR2G	-351
MRE11	-382
RAD1	-410
BRD1	-440
TAF4	-484
PRDM1	-686
RRM2B	-724
IGFBP3	-725
ELL	-755
CNOT8	-790
POLR2K	-795
MSH2	-904
PRELID3A	-984
PRDX1	-1010
TAF5	-1088
PRR5	-1177
HUS1	-1275
KAT6A	-1324
PIP4K2C	-1350
CCNK	-1375
COX18	-1408
CCNT2	-1429
YWHAG	-1477
COX19	-1493
POLR2C	-1547
PERP	-1563
AKT3	-1580
PRKAB2	-1585
TNFRSF10D	-1621
SESN2	-1789
MAPKAPK5	-1948
BLM	-1963
E2F7	-1999
SURF1	-2049
MLST8	-2078
TTC5	-2091
TNRC6A	-2107
TAF4B	-2117
BARD1	-2156
CDKN1A	-2242
CDK5	-2315
CDK5R1	-2377
MLH1	-2409
RPS27A	-2472
TP53RK	-2553
RHNO1	-2686
GTF2F2	-3076
TP53INP1	-3087
TAF11	-3192
YWHAE	-3214
PLK3	-3410
CNOT6	-3666
TMEM219	-3691
TP53BP2	-3693
TPX2	-3710
CRADD	-3717
GSR	-3723
MTA2	-3732
AIFM2	-3793
FAS	-3819
RAD51D	-3866
CCNE1	-4003
CASP6	-4088
LAMTOR1	-4126
RFC5	-4136
BRIP1	-4248
PRKAA2	-4524
CCNA1	-4580
KAT5	-4633
SFN	-4660
MOV10	-4794
ATRIP	-4882
L3MBTL1	-4987
TSC1	-4997
CNOT6L	-5295
TNFRSF10C	-5335
ERCC3	-5361
CDK9	-5440
TP53I3	-5473
TNKS1BP1	-5522
ERCC2	-5783
BCL6	-6002
PPP2CB	-6157
COX20	-6251
CCNG1	-6312
SCO2	-6335
PIP4K2A	-6480
SGK1	-6558
BTG2	-6659
CDK2	-6684
CASP1	-6717
TAF7	-6785
FANCC	-6835
UBC	-6842
NPM1	-6941
RABGGTA	-7330
STEAP3	-7393
CCNH	-7541
TP63	-7582
POLR2L	-7683
CASP10	-7728
TAF1L	-8088
COX6C	-8152
TXN	-8397
NUAK1	-8604
TAF6	-9176
POLR2J	-9382
NLRC4	-9452
ELOA2	-9527

---

REACTOME_CELLULAR_RESPONSES_TO_STIMULI

REACTOME_CELLULAR_RESPONSES_TO_STIMULI

	1314
set	REACTOME_CELLULAR_RESPONSES_TO_STIMULI
setSize	779
pANOVA	7e-08
s.dist	0.114
p.adjustANOVA	1.15e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
P4HB	11751
SOD3	11617
PREB	11612
MT1B	11489
RPL39L	11403
TUBB8	11383
TUBB1	11311
DYNLL2	11280
CDKN2B	11226
H2AC14	11207
DYNC1LI2	11173
MAFK	11159
PSMD3	11142
SYVN1	11015
COX5A	10947
GSTP1	10904
NUP37	10891
ATP6V0C	10831
EXOSC9	10825
MEF2D	10782

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
P4HB	11751.0
SOD3	11617.0
PREB	11612.0
MT1B	11489.0
RPL39L	11403.0
TUBB8	11383.0
TUBB1	11311.0
DYNLL2	11280.0
CDKN2B	11226.0
H2AC14	11207.0
DYNC1LI2	11173.0
MAFK	11159.0
PSMD3	11142.0
SYVN1	11015.0
COX5A	10947.0
GSTP1	10904.0
NUP37	10891.0
ATP6V0C	10831.0
EXOSC9	10825.0
MEF2D	10782.0
TATDN2	10756.0
H2BC3	10676.0
HSPA4L	10661.0
ACTR10	10640.0
RPS24	10632.0
H3C3	10604.0
ASF1A	10602.0
CREB3L3	10553.0
EIF2AK3	10539.0
TNRC6C	10537.0
EXOSC3	10479.0
TLN1	10454.0
PSMC1	10399.0
DNAJC7	10381.0
ERF	10360.0
AQP8	10355.0
ZBTB17	10348.0
CCL2	10342.0
MT1A	10269.0
COX7A2L	10235.0
H3C8	10202.0
CDKN2D	10181.0
PSMB1	10173.0
BTRC	10171.0
UBA52	10169.0
MAPK14	10146.0
NUP85	10105.0
EXTL1	10082.0
EP400	10070.0
ATR	10067.0
RPL26	9894.0
PSMC6	9892.0
RPL27	9834.0
CDC23	9833.0
CEBPB	9779.0
CASTOR1	9754.0
LMNA	9748.0
ATP6V1D	9745.0
CAMK2G	9730.0
HSPA14	9728.0
JUN	9721.0
XPO1	9708.0
CXCL8	9677.0
MT2A	9671.0
DNAJA4	9633.0
LAMTOR4	9628.0
MYDGF	9611.0
TP53	9551.0
H2BC14	9533.0
TGS1	9515.0
COX14	9444.0
NFYB	9420.0
BLVRB	9400.0
TALDO1	9355.0
COX4I1	9285.0
SERP1	9268.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
CSNK2A1	9219.0
HSBP1	9218.0
COX6B1	9199.0
SIN3A	9180.0
STAT3	9135.0
RPA3	9109.0
TCIRG1	9096.0
NPLOC4	9066.0
DNAJB9	9063.0
H4C8	9007.0
POT1	8988.0
SEH1L	8981.0
KHSRP	8971.0
TLR4	8957.0
HIRA	8927.0
HSPA6	8902.0
ATP6V0E1	8899.0
FOS	8811.0
TERF1	8790.0
TFDP2	8771.0
H2AZ1	8737.0
PSME3	8732.0
DNAJA2	8681.0
HDAC3	8661.0
RELA	8623.0
SRPRB	8622.0
EIF2S1	8553.0
DIS3	8527.0
CREBBP	8505.0
RPL10A	8486.0
ATF6	8448.0
UBN1	8447.0
TUBA1B	8427.0
H2AC8	8407.0
ANAPC10	8406.0
PSMD13	8389.0
BMT2	8386.0
RPS14	8357.0
RPS19BP1	8343.0
RPL24	8299.0
NUP88	8287.0
MIOS	8284.0
RPS20	8266.0
RRAGA	8261.0
NUP42	8255.0
E2F1	8248.0
NDUFA4	8243.0
MAP2K7	8207.0
RPA1	8165.0
RPS27	8146.0
UBXN7	8130.0
EXOSC8	8126.0
KPTN	8091.0
BLVRA	8090.0
FAU	8073.0
PARN	8054.0
RPS5	8053.0
PSMC3	7956.0
RRAGD	7937.0
RPL35	7924.0
UFD1	7888.0
CYCS	7886.0
VHL	7882.0
ATP6V1G2	7876.0
GSK3A	7873.0
ATF5	7858.0
NUP62	7784.0
H4C5	7742.0
PSMA3	7703.0
DYNC1H1	7672.0
RPL36	7593.0
CDK4	7586.0
CITED2	7561.0
CAT	7524.0
BAG5	7523.0
H2BC10	7509.0
RAD50	7503.0
ATP6V0D1	7494.0
KDELR3	7486.0
CARM1	7482.0
TPR	7435.0
PPP1R15A	7419.0
COX6A1	7404.0
PSMD7	7334.0
CREB1	7306.0
SIRT1	7303.0
RANBP2	7289.0
ATP6V1H	7249.0
BAG1	7232.0
GPX7	7217.0
DNAJB11	7213.0
MED1	7212.0
TERF2IP	7210.0
TXNRD2	7175.0
DDIT3	7173.0
RNF2	7121.0
AGO1	6991.0
NUP93	6988.0
RPS15	6917.0
RPS7	6908.0
PSMA7	6898.0
H4C3	6897.0
PSMA1	6861.0
ATP6V0B	6860.0
H1-0	6839.0
FLCN	6777.0
GCLM	6726.0
NUP214	6722.0
PPARA	6700.0
CREB3L1	6689.0
RPL22	6685.0
TACO1	6680.0
EXOSC6	6642.0
IDH1	6625.0
GPX2	6622.0
NFKB1	6611.0
AKT1	6607.0
RPL37A	6589.0
PSMB2	6549.0
RPL5	6546.0
PSMC4	6484.0
ATM	6477.0
PDIA5	6475.0
RPS18	6474.0
MBTPS1	6456.0
NFYA	6428.0
EDEM1	6403.0
RAE1	6386.0
UBB	6377.0
CDC16	6332.0
CREB3L4	6319.0
CRTC2	6317.0
EEF1A1	6294.0
EXOSC2	6293.0
NUP153	6267.0
PSMD9	6250.0
LAMTOR5	6246.0
LY96	6229.0
TUBB4B	6227.0
HSPB8	6214.0
DCTN1	6189.0
CBX8	6182.0
TFDP1	6154.0
TNRC6B	6127.0
HSPA4	6111.0
SKP2	6108.0
CA9	6102.0
NUP188	6088.0
NCOR1	6071.0
PALB2	6043.0
TUBB2B	6024.0
PPP2R5B	6021.0
PSMD14	5956.0
MYC	5940.0
AKT2	5870.0
NUP54	5830.0
H1-5	5825.0
MAP1LC3B	5812.0
RBX1	5779.0
H4C9	5774.0
PSMA6	5773.0
DCTN5	5764.0
CUL7	5727.0
COX5B	5725.0
RB1	5689.0
EP300	5668.0
NPRL2	5651.0
ARNT	5594.0
RPS6	5583.0
HIF1A	5570.0
CABIN1	5545.0
ATF2	5532.0
NUP133	5499.0
TUBA1A	5468.0
NCF2	5455.0
VCP	5453.0
PSME2	5380.0
HSPA9	5350.0
HSPB2	5349.0
HSPH1	5347.0
ST13	5345.0
RPL13	5324.0
PSMD11	5320.0
UBE2S	5276.0
COX8A	5268.0
CBX4	5225.0
NOX5	5171.0
CDC26	5157.0
RPL18	5130.0
H2AC18	5121.5
H2AC19	5121.5
GCLC	5097.0
ANAPC1	5092.0
CDKN1B	5083.0
EED	5078.0
H2BC8	5070.0
PSMB5	5052.0
EXOSC5	5051.0
ELOB	5019.0
RPL11	5014.0
RPLP2	4945.0
RPL37	4942.0
RPL7	4893.0
BAG3	4888.0
NUP58	4880.0
RPL19	4852.0
HSPA1B	4850.0
PSMB3	4835.0
SCMH1	4833.0
AAAS	4718.0
AGO3	4706.0
ATP6V1G1	4680.0
RPL3L	4652.0
CYBA	4649.0
NPRL3	4609.0
SP1	4581.0
FKBP14	4563.0
PRDX2	4555.0
RPA2	4484.0
EXTL3	4472.0
CREB3	4432.0
RRAGC	4408.0
DEDD2	4384.0
DYNC1LI1	4367.0
DCTN3	4358.0
SEC31A	4349.0
NUP107	4332.0
CEBPG	4312.0
RHEB	4311.0
NDC1	4258.0
SRPRA	4244.0
TXN2	4223.0
PGR	4206.0
CAMK2B	4182.0
PSME4	4171.0
SLC7A11	4164.0
H3C1	4153.0
COX16	4096.0
HSF1	4062.0
H3-3A	4052.0
MDM2	4051.0
H2BC11	4044.0
UBE2D3	4033.0
GSK3B	4021.0
RPL8	4020.0
GSTA1	3984.0
SLC38A9	3942.0
ELOC	3936.0
PSMD12	3928.0
MAP2K6	3919.0
RBBP4	3906.0
CCNE2	3867.0
CREB3L2	3850.0
CDKN2A	3849.0
ANAPC7	3809.0
TUBB3	3788.0
CSNK2B	3763.0
COX7C	3738.0
MAPK7	3714.0
PSMD5	3711.0
RPS23	3706.0
HDGF	3703.0
RPS13	3696.0
PSMB8	3681.0
MAP4K4	3644.0
PSMA4	3640.0
HSPA12B	3620.0
DEPDC5	3608.0
SCO1	3592.0
NBN	3589.0
RPS11	3544.0
RPLP0	3496.0
H1-4	3395.0
ANAPC5	3355.0
CLOCK	3329.0
FZR1	3328.0
COX11	3319.0
ANAPC4	3312.0
CTDSP2	3311.0
DNAJC3	3289.0
ATOX1	3263.0
HMOX2	3234.0
EIF2AK1	3232.0
KICS2	3230.0
H1-1	3228.0
HMOX1	3178.0
H3C6	3151.0
CREBRF	3142.0
LAMTOR3	3112.0
HSP90B1	3092.0
H2AX	3086.0
GOSR2	3081.0
PSMD1	3063.0
H1-2	3039.0
WDR59	3025.0
MT1E	2997.0
EGLN1	2979.0
LAMTOR2	2942.0
NOTCH1	2914.0
WIPI1	2907.0
RPTOR	2905.0
MT1G	2832.0
ATP6V1C1	2816.0
CXXC1	2806.0
MINK1	2802.0
UBE2D2	2801.0
GPX1	2797.0
ATP6V1G3	2773.0
NUP43	2770.0
CDC27	2701.0
IFNB1	2681.0
NFYC	2680.0
ATP6V1B1	2634.0
TKT	2548.0
RPL27A	2534.0
LIMD1	2483.0
NR3C1	2470.0
NUP98	2445.0
NCOA6	2419.0
RPS21	2412.0
RPL30	2387.0
ACD	2358.5
PSMB9	2322.0
H4C1	2273.0
RPL35A	2255.0
TPP1	2211.0
MAPK8	2156.0
MAPK11	2152.0
HSPA8	2120.0
HIF3A	2118.0
HSP90AB1	2115.0
SNCB	2114.0
MAPK3	2077.0
RPS2	2069.0
RPL3	2052.0
NUP160	2051.0
SESN1	2010.0
ANAPC2	1989.0
EIF2AK4	1936.0
PRDX3	1876.0
CCNA2	1874.0
RPL18A	1823.0
DCP2	1742.0
MDM4	1716.0
PGD	1693.0
TINF2	1628.0
EHMT2	1533.0
PSMC5	1519.0
H2AC6	1509.0
TUBA8	1505.0
BMI1	1490.0
BRCA1	1471.0
SKP1	1470.0
RPL7A	1463.0
SMARCD3	1435.0
H4C4	1434.0
UBE2D1	1355.0
ACTR1A	1341.0
CLEC1B	1328.0
RPS3	1291.0
EXOSC4	1271.0
MTOR	1229.0
EPO	1200.0
ARFGAP1	1182.0
AGO4	1166.0
PRDX5	1143.0
RPL36AL	1019.5
KDM6B	1017.0
H3C2	1002.0
APOA1	983.0
SZT2	980.0
ALB	974.0
CRYAB	959.0
TERF2	954.0
IMPACT	949.0
DNAJB1	920.0
MAPK1	915.0
FKBP4	878.0
DCTN6	866.0
H3-3B	859.0
ADD1	856.0
MAPKAPK2	775.0
MAP2K4	749.0
PRKCD	733.0
CSNK2A2	723.0
HMGA2	684.0
E2F2	656.0
TBL1XR1	644.0
VEGFA	633.0
DYNC1I2	583.0
RPS27L	566.0
ID1	539.0
RPL26L1	476.0
LRPPRC	440.0
SUZ12	349.0
MT1X	335.0
RPL6	325.0
MUL1	313.0
TUBB6	295.0
TXNRD1	268.0
TRIB3	187.0
RPS9	183.0
MT1M	170.0
XBP1	140.0
MAPKAPK3	135.0
RPS10	102.0
NQO1	82.0
NCOA1	37.0
PSMF1	4.0
SIN3B	-46.0
NOX4	-69.0
RPS6KA2	-110.0
HSPA13	-122.0
HIKESHI	-153.0
CRTC1	-163.0
H2BC1	-192.0
EXTL2	-220.0
RPS3A	-233.0
H2BC4	-260.0
EHMT1	-280.0
RPS26	-319.0
WTIP	-339.0
EZH2	-344.0
H2BC5	-354.0
MRE11	-382.0
CUL3	-394.0
SEM1	-434.0
EIF2S2	-483.0
BACH1	-552.0
HM13	-554.0
RPL9	-564.0
MT1F	-600.0
FNIP2	-669.0
NUP35	-710.0
RPS19	-748.0
ATP6V1E2	-762.0
EPAS1	-831.0
PSMC2	-844.0
KEAP1	-855.0
KLHDC3	-891.0
RPS25	-928.0
PRDX1	-1010.0
MAP2K3	-1030.0
GCN1	-1039.0
GPX8	-1062.0
RPL17	-1074.0
CDK6	-1114.0
HSPA2	-1150.0
CDKN2C	-1154.0
RPS15A	-1190.0
RPL31	-1191.0
ETS1	-1217.0
NFE2L2	-1323.0
SSR1	-1346.0
ATF3	-1381.0
RPL41	-1400.0
COX18	-1408.0
HMGA1	-1414.0
HSPA12A	-1460.0
RPL21	-1464.0
MTF1	-1490.0
COX19	-1493.0
MT1H	-1576.0
AKT3	-1580.0
RPS28	-1593.0
SEC13	-1604.0
FNIP1	-1631.0
H3C11	-1655.0
BAG4	-1668.0
H4C12	-1743.0
H2BC12	-1772.0
SERPINH1	-1788.0
SESN2	-1789.0
RPS29	-1802.0
TNFRSF21	-1835.0
DPP3	-1853.0
MAPKAPK5	-1948.0
SQSTM1	-1966.0
RPL4	-1976.0
WDR24	-2029.0
MAFG	-2037.0
H2BC17	-2040.0
SURF1	-2049.0
MLST8	-2078.0
HBA1	-2095.0
RPL14	-2101.0
TNRC6A	-2107.0
H2BC21	-2129.0
FKBP5	-2158.0
PSMD6	-2201.0
NCOA2	-2231.0
CDKN1A	-2242.0
PSMD8	-2294.0
TUBA4A	-2325.0
HSPA1L	-2361.0
TUBA4B	-2380.0
PLA2G4B	-2415.0
RPS16	-2419.0
DNAJA1	-2443.0
RPS27A	-2472.0
PHC3	-2479.0
CUL2	-2524.0
SOD2	-2532.0
GRB10	-2556.0
EXOSC7	-2604.0
ANAPC11	-2624.0
HELZ2	-2684.0
PSMA2	-2726.0
H4C13	-2741.0
MRPL18	-2783.0
E2F3	-2835.0
CRTC3	-2839.0
BAG2	-2842.0
DNAJC2	-2895.0
NLRP3	-2898.0
ABCC1	-2902.0
GFPT1	-2928.0
NUP205	-3003.0
RPLP1	-3066.0
H2BC6	-3080.0
CAPZA2	-3094.0
H2BC15	-3142.0
CAPZA1	-3166.0
ATP6V1C2	-3189.0
PSMB4	-3191.0
PDIA6	-3199.0
YWHAE	-3214.0
RPL12	-3217.0
RPL38	-3220.0
H2AC20	-3235.0
RING1	-3272.0
HSP90AA1	-3286.0
AJUBA	-3295.0
H3-4	-3300.0
CHAC1	-3315.0
ATP6V1A	-3322.0
RPL32	-3366.0
H2AZ2	-3381.0
ATP6V0D2	-3402.0
RPL28	-3461.0
PSMA8	-3478.0
NUP50	-3509.0
GPX3	-3540.0
AKT1S1	-3551.0
TNIK	-3554.0
NCF4	-3559.0
HSPA1A	-3563.0
ATP6V1F	-3574.0
SLC46A1	-3595.0
PTK6	-3658.0
NR1D1	-3664.0
NUP210	-3669.0
IL6	-3702.0
H2BC9	-3718.5
H3C7	-3718.5
GSR	-3723.0
LMNB1	-3736.0
CAPZB	-3829.0
POM121	-3922.0
MEF2C	-3930.0
EXOSC1	-3957.0
PSMB10	-3966.0
TUBA1C	-3972.0
ANAPC16	-4002.0
CCNE1	-4003.0
HIGD1A	-4014.0
CAMK2A	-4043.0
RPL15	-4110.0
LAMTOR1	-4126.0
RAI1	-4137.0
ANAPC15	-4142.0
PPARGC1A	-4177.0
H2BC26	-4236.0
NR3C2	-4264.0
PSMA5	-4274.0
FBXL17	-4280.0
RPL29	-4307.0
FABP1	-4322.0
CCAR2	-4391.0
BMAL1	-4422.0
PHC2	-4460.0
YIF1A	-4467.0
MT3	-4529.0
CRYBA4	-4575.0
CCNA1	-4580.0
CCS	-4626.0
KAT5	-4633.0
HSPA5	-4707.0
CHD9	-4719.0
RPS6KA1	-4727.0
ERN1	-4747.0
PSMB6	-4786.0
MOV10	-4794.0
NPAS2	-4830.0
H1-3	-4858.0
SHC1	-4863.0
ATP6V1B2	-4870.0
ASNS	-4949.0
DYNLL1	-4954.0
HERPUD1	-4975.0
RPL22L1	-5004.0
MT4	-5078.0
NUDT2	-5143.0
SOD1	-5185.0
NCOR2	-5218.0
IGFBP7	-5236.0
RPS8	-5241.0
PSMB7	-5258.0
DYNC1I1	-5309.0
DCTN2	-5318.0
STAP2	-5325.0
UBE2C	-5371.0
ERO1A	-5406.0
CALR	-5434.0
CAMK2D	-5437.0
DNAJB6	-5443.0
DDX11	-5483.0
ATF4	-5542.0
IGFBP1	-5545.0
MAPK9	-5628.0
EGLN2	-5644.0
GSTA3	-5655.0
PTGES3	-5736.0
RPSA	-5754.0
GML	-5800.0
SRXN1	-5806.0
STIP1	-5817.0
ATP6V0E2	-5841.0
NUP155	-5949.0
CBX6	-5952.0
HSPB1	-6020.0
USP46	-6024.0
H2AJ	-6028.0
RPL34	-6070.0
TUBA3D	-6078.0
WFS1	-6121.0
RXRA	-6154.0
PSMD2	-6176.0
APOB	-6247.0
COX20	-6251.0
ATP6V1E1	-6310.0
SCO2	-6335.0
CUL1	-6388.0
DCTN4	-6447.0
H4C6	-6464.0
VENTX	-6569.0
CDK2	-6684.0
IL1A	-6686.0
UBC	-6842.0
H4C2	-6995.0
RORA	-7027.0
GPX5	-7101.0
TUBB4A	-7113.0
SH3BP4	-7116.0
ME1	-7332.0
CBX2	-7506.0
RPL23	-7518.0
UBE2E1	-7595.0
TUBA3C	-7603.0
ETS2	-7691.0
MAPK10	-7702.0
PSME1	-7763.0
HYOU1	-7835.0
MIR24-1	-7841.0
PRDX6	-7871.0
MAP3K5	-7881.0
DCSTAMP	-7882.0
RPL13A	-7929.5
H3C4	-8000.0
TUBB2A	-8021.0
RPS12	-8043.0
POM121C	-8073.0
HIF1AN	-8122.0
RPL23A	-8127.0
H2AC4	-8140.0
COX6C	-8152.0
H3C10	-8206.0
CSRP1	-8230.0
TXN	-8397.0
PSMB11	-8541.0
HBB	-8569.0
NRIP1	-8667.0
H2AC7	-8707.5
H2BC7	-8707.5
TUBA3E	-8723.0
EGLN3	-8792.0
CAPZA3	-8975.0
PHC1	-9004.0
TUBAL3	-9053.0
H3C12	-9106.0
ACADVL	-9132.0
ITFG2	-9183.0
TRIM21	-9251.0
H2BC13	-9329.0
GPX6	-9458.0
RPL10L	-9546.0
HBA2	-9572.0
MIR24-2	-10026.0
TXNIP	-10089.0
RLN1	-10188.0

---

REACTOME_ADAPTIVE_IMMUNE_SYSTEM

REACTOME_ADAPTIVE_IMMUNE_SYSTEM

	79
set	REACTOME_ADAPTIVE_IMMUNE_SYSTEM
setSize	729
pANOVA	2.5e-07
s.dist	0.112
p.adjustANOVA	3.45e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD3D	11806
CTLA4	11744
CD3G	11740
PILRB	11713
LCK	11679
CD19	11678
KLRF1	11662
TRIM69	11636
CD8B	11589
BTLA	11502
GRAP2	11494
PDCD1	11469
CD3E	11468
CD209	11464
RNF114	11462
TUBB8	11383
LILRB3	11381
CD247	11377
ASB10	11362
RASGRP2	11346

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD3D	11806
CTLA4	11744
CD3G	11740
PILRB	11713
LCK	11679
CD19	11678
KLRF1	11662
TRIM69	11636
CD8B	11589
BTLA	11502
GRAP2	11494
PDCD1	11469
CD3E	11468
CD209	11464
RNF114	11462
TUBB8	11383
LILRB3	11381
CD247	11377
ASB10	11362
RASGRP2	11346
TUBB1	11311
TRIM41	11303
S100A1	11297
DYNLL2	11280
CD79A	11237
CTSE	11222
HLA-DQA1	11196
DYNC1LI2	11173
STX4	11170
CLEC2D	11160
PSMD3	11142
VAV1	11098
MYLIP	11009
ICAM3	10918
FBXL22	10901
VASP	10862
KIF23	10843
PPP2R5D	10754
CTSS	10734
CSK	10710
HLA-F	10704
ACTR10	10640
CD300C	10578
NFKBIE	10535
SLAMF7	10468
KIF5A	10456
ASB16	10434
PSMC1	10399
CD1C	10393
SLAMF6	10382
BCL10	10375
RNF34	10341
TRIM37	10316
RNF14	10277
KCTD6	10198
IKBKB	10186
HLA-DMB	10184
UBE2M	10180
PSMB1	10173
BTRC	10171
UBA52	10169
LAT	10161
FBXL14	10148
UBA5	10140
PDPK1	10091
HECTD1	10078
AP1M2	10055
KIF5B	10054
HLA-DOB	10034
AP1B1	9985
PTPN22	9969
UBE2K	9963
KIF15	9909
NFATC3	9905
PSMC6	9892
PJA2	9890
SMURF2	9848
CDC23	9833
KBTBD6	9793
UBE2G2	9792
LILRA4	9788
RAP1B	9757
RNF138	9666
KLHL21	9661
RAP1GAP2	9624
UBE2W	9585
DTX3L	9562
ITGB2	9461
UBA3	9455
AP2A2	9440
LCP2	9437
RAB7A	9383
TREML4	9345
CD81	9339
FBXL3	9325
PPP2R5A	9306
ORAI1	9238
PSMD4	9234
HLA-E	9228
FBXL15	9202
TAPBP	9184
HERC4	9143
JAML	9117
CD74	9106
HMGB1	9074
CD160	9048
DNM2	9028
TLR4	8957
UBE2L3	8944
CLTC	8900
ICAM5	8887
YWHAB	8801
KIF20A	8767
FBXO44	8757
PSME3	8732
SEC61G	8671
RELA	8623
SOCS1	8601
ATG14	8600
B2M	8560
RNF7	8452
KIF11	8438
TUBA1B	8427
HCST	8421
ANAPC10	8406
PSMD13	8389
PIK3R4	8377
KIF2A	8369
FBXL16	8317
KCTD7	8268
KLRD1	8222
YWHAZ	8195
REL	8087
GLMN	8081
FGA	8035
PRKACB	8013
RNF41	8004
ORAI2	7989
RNF123	7984
CCNF	7968
PRKACA	7965
ULBP1	7959
PSMC3	7956
ERAP2	7941
KBTBD7	7923
VHL	7882
NRAS	7875
AP2A1	7850
UBE2Q2	7817
FBXO30	7801
SAR1B	7795
KIF3A	7774
HECTD3	7769
PSMA3	7703
CD28	7686
MKRN1	7684
PTPN6	7678
UBOX5	7677
DYNC1H1	7672
GAN	7657
CD40	7644
LAIR1	7617
ASB7	7598
FBXO21	7551
KLRK1	7506
ICAM1	7440
CLEC4G	7408
KIF22	7405
BLMH	7385
PSMD7	7334
LRR1	7332
PIK3CD	7276
FBXW7	7200
TRIM63	7155
CDC42	7131
RNF126	7064
KIF3B	7019
OSBPL1A	6977
ITGAL	6976
FBXO6	6972
PSMA7	6898
PSMA1	6861
FBXO7	6820
RBBP6	6670
KLHL11	6653
NFKB1	6611
AKT1	6607
BTN2A1	6597
PSMB2	6549
SIPA1	6545
SIGLEC1	6491
PSMC4	6484
UBE2Q1	6472
MYD88	6416
FBXO15	6407
MEX3C	6406
FBXO41	6404
KIF2C	6395
UBB	6377
COL3A1	6367
ASB6	6351
FBXW2	6343
CDC16	6332
KLC1	6303
PSMD9	6250
LY96	6229
TUBB4B	6227
SRC	6197
DCTN1	6189
THEM4	6166
CD8A	6141
KIF18A	6129
SKP2	6108
CD79B	6090
VAMP8	6082
HLA-DPA1	6073
SEC61A1	6064
ITCH	6063
TUBB2B	6024
PPP2R5B	6021
HLA-B	6020
UBE2V1	6001
PSMD14	5956
ASB8	5939
RNF19B	5919
UBE2O	5875
AKT2	5870
CD300LF	5836
DNM1	5833
RAF1	5793
PTPRC	5790
RBX1	5779
PSMA6	5773
DCTN5	5764
RIPK2	5736
CD200	5734
CUL7	5727
FBXW4	5726
KLHL22	5724
NECTIN2	5717
VCAM1	5678
PTPRJ	5677
PAK2	5671
C3	5665
SEC23A	5642
PTPN11	5640
DAPP1	5622
UBE4A	5618
UBE3A	5579
SEC24A	5482
RAP1GAP	5472
TUBA1A	5468
NCF2	5455
TRIM50	5450
ENAH	5407
PSME2	5380
TREML2	5364
PSMD11	5320
UBE2S	5276
CDC26	5157
SIGLEC10	5155
ZAP70	5143
IFI30	5138
FBXL4	5136
CD300E	5135
ANAPC1	5092
HLA-DRB1	5087
PSMB5	5052
FBXO2	5041
CALM1	5021
ELOB	5019
TRIM36	4996
MGRN1	4994
PPL	4930
LTN1	4906
INPP5D	4892
HERC1	4846
CTSC	4842
PSMB3	4835
RCHY1	4826
PPP2R1B	4800
ACTR1B	4795
RNF19A	4782
UBR2	4779
PAK1	4761
TPP2	4712
FBXO32	4667
CYBA	4649
KLHL9	4642
FBXW5	4627
HLA-DRA	4610
PLCG1	4604
NPEPPS	4564
SEC61B	4500
NCR3LG1	4479
UNKL	4478
RNF4	4464
AP1G1	4423
SPSB1	4397
DYNC1LI1	4367
DCTN3	4358
SEC31A	4349
RBCK1	4346
SIGLEC6	4301
MALT1	4261
PIK3CA	4175
PSME4	4171
CHUK	4148
EVL	4121
PPP2R5C	4099
LONRF1	4057
UBE2D3	4033
AP2S1	4029
TRPC1	3988
ELOC	3936
PSMD12	3928
NCR1	3901
UBE2B	3873
BTN3A1	3819
ANAPC7	3809
TUBB3	3788
UFL1	3753
CD33	3729
RAP1A	3718
PSMD5	3711
PSMB8	3681
MICB	3643
PSMA4	3640
DZIP3	3495
HERC5	3473
RNF115	3445
UBA6	3394
TRIM9	3392
CD274	3380
FGB	3371
WSB1	3370
ANAPC5	3355
FBXL20	3335
FZR1	3328
ANAPC4	3312
SNAP23	3273
UBAC1	3221
PRKCB	3154
SEC24C	3133
AP1M1	3128
PSMD1	3063
PIK3R3	3043
TAP1	3001
PVR	2929
PPP3CB	2916
SOS1	2865
CTSB	2805
UBE2D2	2801
TRAF7	2766
LAIR2	2748
FYB1	2718
CDC27	2701
HLA-DRB5	2685
FBXW8	2672
AP1S1	2669
CTSH	2638
THOP1	2590
PPIA	2546
PRKCQ	2519
TREM1	2448
TRIM11	2436
STIM1	2360
RICTOR	2329
PPP2R5E	2327
PSMB9	2322
UBR1	2321
UBR4	2290
PIK3C3	2277
SPTBN2	2275
KLHL3	2247
PDCD1LG2	2185
ITK	2180
ASB14	2176
SPSB2	2174
DCAF1	2142
CTSK	2090
MAPKAP1	2024
LILRB4	2020
ANAPC2	1989
FBXL8	1967
TRIM39	1960
BLNK	1918
CDC34	1908
CTSA	1820
ITGAV	1791
FBXO9	1741
UBE2D4	1732
FBXL13	1679
UBE2F	1669
VAMP3	1589
RNF25	1588
PTEN	1587
RACGAP1	1566
WWP1	1551
COL1A1	1543
TRIP12	1530
PSMC5	1519
ITPR3	1510
TUBA8	1505
KLHL41	1501
SKP1	1470
UBE2D1	1355
PPP2CA	1345
ACTR1A	1341
RNF213	1338
HERC6	1320
CD36	1267
AREL1	1242
MTOR	1229
ITPR2	1217
HLA-C	1212
CD96	1207
MIB2	1138
TAB2	1079
ASB3	1069
TREML1	975
CD1A	971
SIAH1	935
FBXO31	872
DCTN6	866
PPP2R1A	849
FBXL18	842
KLHL2	812
UBE2R2	801
CD101	780
HLA-DPB1	768
AP2B1	724
HLA-DMA	698
PIK3R2	686
BTBD6	681
SPSB4	645
FBXL5	635
ARIH2	594
DYNC1I2	583
LILRA5	466
TRAT1	420
FCGR3A	410
TUBB6	295
UBE3B	237
KLHL20	219
TRIB3	187
CANX	160
SH3RF1	147
FBXW12	74
FBXL19	44
CBLB	40
PSMF1	4
HRAS	-31
MAP3K8	-54
MAP3K14	-62
TAP2	-129
FKBP1A	-210
TRAIP	-216
BLK	-243
PPP3R1	-256
PAG1	-266
CARD11	-272
MADCAM1	-311
SIAH2	-371
BTBD1	-380
RNF130	-383
CUL3	-394
FBXO40	-404
SEM1	-434
ITGB7	-449
BTNL9	-456
LRRC41	-487
ITGA4	-497
KIR2DL4	-550
TRAF6	-626
HLA-G	-673
CDH1	-689
IFITM1	-719
ASB13	-732
PSMC2	-844
KEAP1	-855
NFKBIA	-865
RILP	-880
FBXO22	-886
FGG	-894
HLA-A	-902
UBE2E3	-961
CDC20	-1019
MRC2	-1027
UBE2G1	-1045
ERAP1	-1076
HLA-DQB1	-1110
FBXL12	-1121
RNF6	-1165
PRR5	-1177
AP1S3	-1188
UBE2U	-1201
CD34	-1228
RNF111	-1255
TLR2	-1307
GRB2	-1330
ASB1	-1365
CD14	-1377
MAP3K7	-1507
COL1A2	-1569
AKT3	-1580
SEC13	-1604
PRKACG	-1626
KIF3C	-1639
UBE3C	-1645
KIF26A	-1658
NFKBIB	-1738
SELL	-1794
LRSAM1	-1811
TLR1	-1972
ARF1	-1980
SEC22B	-2002
ZNRF2	-2034
SMURF1	-2045
CTSV	-2071
MLST8	-2078
PRKG1	-2157
PSMD6	-2201
NFATC1	-2209
HERC3	-2238
FBXW11	-2247
UBE2J2	-2266
LILRA3	-2277
PSMD8	-2294
LYN	-2322
TUBA4A	-2325
YES1	-2333
TUBA4B	-2380
CD80	-2384
KLC2	-2422
RPS27A	-2472
COL17A1	-2486
CUL2	-2524
ITGB5	-2538
HACE1	-2566
ANAPC11	-2624
FBXO11	-2639
PSMA2	-2726
PIK3R1	-2742
RAC1	-2752
CD22	-2800
TRIM71	-2816
FBXO17	-2873
RNF182	-2877
NCK1	-2888
UBE2E2	-2908
FBXW9	-2921
ICAM4	-2926
COL2A1	-2938
CLEC2B	-2955
BTNL8	-2976
KLHL25	-2989
KBTBD8	-2991
CAPZA2	-3094
SEC24D	-3129
CAPZA1	-3166
BECN1	-3180
PSMB4	-3191
CRTAM	-3205
PIK3CB	-3212
PPP3CA	-3255
ASB4	-3303
AP2M1	-3365
STUB1	-3378
AHCYL1	-3425
PSMA8	-3478
LGMN	-3501
NCF4	-3559
HECTD2	-3565
CXADR	-3694
CLTA	-3747
UBE2V2	-3757
XDH	-3763
LMO7	-3805
BTN1A1	-3810
CAPZB	-3829
SEC24B	-3858
ULBP3	-3898
PSMB10	-3966
TUBA1C	-3972
RAPGEF4	-3981
KIFAP3	-4114
TIRAP	-4162
CD1D	-4192
PSMA5	-4274
KLRG1	-4298
NCR3	-4338
CTSL	-4367
LNX1	-4398
NCR2	-4401
HERC2	-4445
UBE2Z	-4475
KLC3	-4481
SEC61A2	-4521
DNM3	-4545
KIR3DL1	-4613
UBA7	-4653
PIANP	-4699
HSPA5	-4707
RASGRP1	-4771
SIGLEC7	-4778
PSMB6	-4786
CUL5	-4806
MICA	-4847
UBE2H	-4933
DYNLL1	-4954
ITPR1	-5018
RNF220	-5019
KIF4B	-5023
SH2D1B	-5028
NEDD4	-5049
SYK	-5067
ZBTB16	-5134
FBXO27	-5179
ASB17	-5180
PSMB7	-5258
DYNC1I1	-5309
DCTN2	-5318
KLRB1	-5340
UBE2C	-5371
RNF217	-5389
FBXO4	-5429
CALR	-5434
CD1B	-5451
CD200R1	-5518
CD300LD	-5647
KLHL5	-5697
SIGLEC12	-5765
FYN	-5782
HLA-DQB2	-5823
PDIA3	-5865
HLA-DQA2	-5890
TRIM4	-5899
CTSO	-5968
PLCG2	-6046
UBE2L6	-6074
TUBA3D	-6078
PPP2CB	-6157
PSMD2	-6176
BTN3A3	-6347
CUL1	-6388
LILRA2	-6405
COLEC12	-6433
DCTN4	-6447
HLA-DOA	-6468
RAPGEF3	-6478
NPDC1	-6565
UBE2J1	-6610
RASGRP3	-6620
BTNL2	-6658
HECW2	-6728
RAET1E	-6734
UBE2N	-6780
LNPEP	-6802
UBC	-6842
DET1	-6890
BTN2A2	-6906
PRKN	-6909
FBXW10	-6910
FBXL7	-6924
ASB15	-6959
ASB18	-6966
CD300LG	-7037
CD86	-7049
UBE3D	-7074
KLC4	-7078
TUBB4A	-7113
CENPE	-7223
ASB5	-7360
ATG7	-7371
ITGB1	-7482
UBE2E1	-7595
TUBA3C	-7603
KLHL42	-7605
KRAS	-7660
CD226	-7695
PSME1	-7763
LILRB5	-7785
SH3GL2	-7827
ANAPC13	-7845
LILRB2	-7932
PILRA	-8014
TUBB2A	-8021
BTN3A2	-8057
KIR3DL2	-8066
CD4	-8069
TRIM32	-8141
NEDD4L	-8238
CTSF	-8392
NFATC2	-8401
RNF144B	-8520
PSMB11	-8541
ICAM2	-8577
TUBA3E	-8723
SIGLEC5	-8743
PIK3AP1	-8790
SIGLEC11	-8853
LILRB1	-8888
SOCS3	-8908
CAPZA3	-8975
CTSD	-9046
TUBAL3	-9053
ASB2	-9069
S100A9	-9088
TLR6	-9151
SIGLEC9	-9160
CD207	-9200
TRIM21	-9251
S100A8	-9296
LAG3	-9305
ICOS	-9358
FBXO10	-9381
CD300A	-9391
LILRA1	-9404
CD300LB	-9412
SIGLEC8	-9444
KIF2B	-9529
SFTPD	-9589
OSCAR	-9637
TREM2	-9828
TYROBP	-9882
KLRC1	-9883
ZNRF1	-9889
KIR2DL1	-9904

---

REACTOME_INFECTIOUS_DISEASE

REACTOME_INFECTIOUS_DISEASE

	974
set	REACTOME_INFECTIOUS_DISEASE
setSize	910
pANOVA	2.52e-07
s.dist	0.101
p.adjustANOVA	3.45e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNGT2	11803
CD3G	11740
LCK	11679
GNGT1	11651
CD8B	11589
TAB1	11522
PDCD1	11469
CRB3	11436
PARP10	11422
RPL39L	11403
CORO1A	11396
TUBB8	11383
GNB3	11378
CD247	11377
TLR9	11359
TUBB1	11311
DYNLL2	11280
IFNA1	11270
CD79A	11237
H2AC14	11207

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNGT2	11803.0
CD3G	11740.0
LCK	11679.0
GNGT1	11651.0
CD8B	11589.0
TAB1	11522.0
PDCD1	11469.0
CRB3	11436.0
PARP10	11422.0
RPL39L	11403.0
CORO1A	11396.0
TUBB8	11383.0
GNB3	11378.0
CD247	11377.0
TLR9	11359.0
TUBB1	11311.0
DYNLL2	11280.0
IFNA1	11270.0
CD79A	11237.0
H2AC14	11207.0
IFNGR1	11180.0
DYNC1LI2	11173.0
PSMD3	11142.0
TRIM28	11100.0
VAV1	11098.0
ST6GALNAC4	11041.0
ISG15	10963.0
VPS33B	10926.0
NUP37	10891.0
IRF7	10885.0
ACTR3	10838.0
TCEA1	10805.0
HLA-F	10704.0
VPS28	10677.0
H2BC3	10676.0
DAXX	10654.0
ARPC4	10649.0
RPS24	10632.0
RCAN3	10631.0
GNAI2	10624.0
DPEP2	10607.0
H3C3	10604.0
LTF	10554.0
IFNA13	10532.0
MTA3	10531.0
ZDHHC8	10428.0
PSMC1	10399.0
GNB2	10374.0
UBE2I	10324.0
HNRNPK	10300.0
NELFB	10298.0
SNRPD2	10271.0
TUFM	10261.0
GTF2F1	10225.0
H3C8	10202.0
IKBKB	10186.0
PSMB1	10173.0
BTRC	10171.0
POLR2E	10170.0
UBA52	10169.0
SNRPF	10159.0
PRKCSH	10158.0
MAPK14	10146.0
VPS39	10128.0
NUP85	10105.0
PDPK1	10091.0
ABI1	10089.0
AP1M2	10055.0
ZBP1	10043.0
TAF15	10036.0
GTF2H5	10024.0
TAF12	10008.0
DDX20	9996.0
AP1B1	9985.0
ANO10	9945.0
RPL26	9894.0
PSMC6	9892.0
CXCR4	9856.0
RPL27	9834.0
DUSP16	9820.0
JUN	9721.0
S1PR1	9720.0
XPO1	9708.0
SUPT5H	9702.0
FXYD6	9670.0
BRMS1	9660.0
NCBP2	9630.0
H2BC14	9533.0
DDX5	9484.0
AP2A2	9440.0
NCBP1	9433.0
VAMP2	9416.0
RAB7A	9383.0
ISCU	9371.0
ATP1B2	9300.0
UBAP1	9272.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
HLA-E	9228.0
NCKIPSD	9227.0
STAT2	9208.0
GEMIN4	9188.0
IFNA16	9121.0
PTK2	9047.0
VPS4B	9032.0
ST6GAL1	9031.0
H4C8	9007.0
IFNA8	8989.0
SEH1L	8981.0
FEN1	8951.0
NELFCD	8950.0
GATAD2B	8932.0
MYO9B	8913.0
RIGI	8912.0
CLTC	8900.0
KPNB1	8882.0
GTF2H1	8877.0
VPS25	8855.0
ACTB	8836.0
SIGMAR1	8829.0
YWHAB	8801.0
ANO8	8798.0
ACTG1	8780.0
PSME3	8732.0
CTDP1	8731.0
HDAC3	8661.0
DDOST	8630.0
RELA	8623.0
POLR2D	8613.0
ATG14	8600.0
B2M	8560.0
GTF2H3	8555.0
CREBBP	8505.0
RPL10A	8486.0
H2AC16	8457.0
TUBA1B	8427.0
CHD3	8412.0
H2AC8	8407.0
IFNAR1	8400.0
PSMD13	8389.0
PIK3R4	8377.0
RPS14	8357.0
GPC2	8334.0
RPL24	8299.0
NUP88	8287.0
RPS20	8266.0
NUP42	8255.0
CHD4	8242.0
PPIG	8231.0
SRPK1	8218.0
REST	8214.0
MAP2K7	8207.0
YWHAZ	8195.0
CHMP7	8148.0
RPS27	8146.0
IMPDH2	8108.0
MAP2K1	8096.0
CYFIP2	8093.0
FAU	8073.0
RPS5	8053.0
SMN1	8042.5
SMN2	8042.5
PRKACB	8013.0
PARP9	7970.0
LIG4	7969.0
PRKACA	7965.0
PSMC3	7956.0
RPL35	7924.0
NMT2	7911.0
ELOA	7897.0
VHL	7882.0
GSK3A	7873.0
GTF2E1	7861.0
CHMP4B	7852.0
AP2A1	7850.0
SAR1B	7795.0
NUP62	7784.0
PCBP2	7782.0
GSDMD	7759.0
H4C5	7742.0
PSMA3	7703.0
HDAC1	7688.0
CD28	7686.0
KPNA5	7685.0
PTPN6	7678.0
DYNC1H1	7672.0
RPL36	7593.0
TBP	7543.0
H2BC10	7509.0
DAD1	7467.0
TPR	7435.0
GUCY2C	7351.0
PSMD7	7334.0
MYO5A	7331.0
CPSF4	7318.0
CREB1	7306.0
STAT1	7294.0
RANBP2	7289.0
CRK	7282.0
EEF2	7278.0
H2AC17	7258.0
XRCC5	7254.0
ATP6V1H	7249.0
PARP1	7236.0
MAVS	7199.0
BRK1	7162.0
IFIH1	7159.0
IFNA6	7135.0
CDC42	7131.0
ST3GAL2	7128.0
ST3GAL1	7090.0
CNBP	7083.0
BAIAP2	7071.0
ARPC5	7068.0
SNRPD1	7057.0
PRKAR1A	7017.0
NUP93	6988.0
TAF9	6942.0
ZDHHC5	6937.0
RPS15	6917.0
RPS7	6908.0
PSMA7	6898.0
H4C3	6897.0
GNG11	6877.0
PSMA1	6861.0
FXYD3	6830.0
ACTR2	6793.0
RNMT	6733.0
NUP214	6722.0
PALS1	6697.0
RPL22	6685.0
VPS37D	6666.0
NFKB1	6611.0
AKT1	6607.0
RPL37A	6589.0
PSMB2	6549.0
RPL5	6546.0
G3BP1	6534.0
DVL1	6513.0
BANF1	6504.0
PML	6494.0
P2RX4	6490.0
PSMC4	6484.0
RPS18	6474.0
HDAC2	6444.0
RAE1	6386.0
UBB	6377.0
ADCY3	6370.0
PDCD6IP	6334.0
EEF1A1	6294.0
NUP153	6267.0
PRKAR2A	6251.0
PSMD9	6250.0
TUBB4B	6227.0
SRC	6197.0
PACS1	6174.0
STT3A	6155.0
GRSF1	6143.0
CD79B	6090.0
NUP188	6088.0
NCOR1	6071.0
ITCH	6063.0
VPS11	6041.0
TUBB2B	6024.0
HLA-B	6020.0
UBE2V1	6001.0
PSMD14	5956.0
VAMP1	5953.0
CTNNB1	5893.0
STX1B	5880.0
AKT2	5870.0
H2AC11	5849.0
NUP54	5830.0
MAP1LC3B	5812.0
RBX1	5779.0
H4C9	5774.0
PSMA6	5773.0
SAP30	5739.0
RIPK2	5736.0
RANGAP1	5723.0
GATAD2A	5722.0
RB1	5689.0
PAK2	5671.0
EP300	5668.0
C3	5665.0
SEC23A	5642.0
PTPN11	5640.0
RPS6	5583.0
CHMP2A	5566.0
VPS33A	5529.0
CCNT1	5525.0
ADCY6	5523.0
VPS41	5508.0
NUP133	5499.0
SEC24A	5482.0
TUBA1A	5468.0
VCP	5453.0
KPNA7	5433.0
NELFE	5395.0
PSME2	5380.0
CEBPD	5331.0
RPL13	5324.0
PSMD11	5320.0
SMAD4	5313.0
CHMP5	5312.0
IRF3	5278.0
POLR2I	5240.0
SUPT4H1	5215.0
SUGT1	5185.0
ANO9	5173.0
FXYD4	5144.0
RPL18	5130.0
H2AC18	5121.5
H2AC19	5121.5
JAK3	5080.0
EED	5078.0
PARP4	5077.0
SIKE1	5076.0
CD163	5075.0
H2BC8	5070.0
PSMB5	5052.0
POLR2A	5042.0
CALM1	5021.0
ARID4A	5020.0
ELOB	5019.0
MASP2	5017.0
RPL11	5014.0
MYH9	4989.0
NT5E	4985.0
ENTPD5	4956.0
RPLP2	4945.0
RPL37	4942.0
PYCARD	4931.0
H2AC15	4918.0
VPS37A	4916.0
MGAT1	4900.0
RPL7	4893.0
NUP58	4880.0
GNG5	4863.0
RPL19	4852.0
PSMB3	4835.0
GNAZ	4813.0
ABI2	4753.0
SUPT16H	4733.0
AAAS	4718.0
FZD7	4686.0
RPL3L	4652.0
CYBA	4649.0
LARP1	4613.0
PLCG1	4604.0
SP1	4581.0
MTA1	4534.0
DOCK2	4518.0
NELFA	4446.0
AP1G1	4423.0
MGAT5	4389.0
GNG3	4372.0
DYNC1LI1	4367.0
MAP2K2	4356.0
NUP107	4332.0
WASF1	4330.0
ANO7	4328.0
MASP1	4288.0
MYO1C	4280.0
IL1B	4268.0
WASL	4260.0
NDC1	4258.0
WASF2	4208.0
TRAF3	4183.0
PSME4	4171.0
H3C1	4153.0
CHUK	4148.0
POLR2F	4146.0
H2BC11	4044.0
FNTB	4031.0
AP2S1	4029.0
NFKB2	4022.0
GSK3B	4021.0
RPL8	4020.0
ARPC2	3978.0
PLK2	3943.0
ELOC	3936.0
PSMD12	3928.0
XRCC6	3920.0
MAP2K6	3919.0
GNG2	3918.0
RBBP4	3906.0
DPEP3	3855.0
TAF2	3833.0
TUBB3	3788.0
TOMM70	3776.0
CAV1	3760.0
POLR2H	3756.0
PRMT1	3725.0
SNRPD3	3720.0
PSMD5	3711.0
RPS23	3706.0
RPS13	3696.0
PSMB8	3681.0
SYT2	3678.0
PSMA4	3640.0
GOLGA7	3629.0
MBD3	3615.0
ATP1B3	3607.0
RPS11	3544.0
NOXO1	3514.0
RPLP0	3496.0
CSNK1A1	3493.0
ARPC3	3483.0
CHMP6	3463.0
RCC1	3413.0
TBK1	3387.0
HGS	3373.0
ADORA2B	3348.0
CDK7	3307.0
EDEM2	3303.0
DNAJC3	3289.0
GTF2A1	3275.0
SFPQ	3266.0
PATJ	3257.0
GANAB	3184.0
HMOX1	3178.0
H3C6	3151.0
RIPK1	3149.0
SEC24C	3133.0
AP1M1	3128.0
FUT8	3099.0
PSMD1	3063.0
TRIM25	3005.0
PHF21A	2921.0
FXYD7	2893.0
SOS1	2865.0
ARPC1A	2833.0
UVRAG	2780.0
NUP43	2770.0
APOBEC3G	2696.0
IFNB1	2681.0
AP1S1	2669.0
GPC1	2591.0
PPIA	2546.0
RPL27A	2534.0
KPNA1	2495.0
NR3C1	2470.0
NUP98	2445.0
SDC3	2435.0
SV2C	2433.0
RPS21	2412.0
RPL30	2387.0
ZCRB1	2379.0
SSRP1	2333.0
PSMB9	2322.0
ROCK1	2300.0
PPIH	2293.0
SAP18	2286.0
PIK3C3	2277.0
H4C1	2273.0
G3BP2	2271.0
SV2B	2265.0
RPL35A	2255.0
GNAT3	2243.0
VPS4A	2225.0
MAPK8	2156.0
GEMIN2	2137.0
HSP90AB1	2115.0
CBX1	2097.0
MAPK3	2077.0
RPS2	2069.0
RPL3	2052.0
NUP160	2051.0
ATP1A3	2017.0
P2RX7	2000.0
SDC4	1931.0
BLNK	1918.0
GNB1	1912.0
GNG7	1870.0
MAN1B1	1853.0
RPL18A	1823.0
ST3GAL3	1802.0
GNAI3	1770.0
TSG101	1714.0
RANBP1	1690.0
WASF3	1670.0
EPS15	1635.0
YWHAH	1632.0
ZDHHC2	1621.0
CBL	1574.0
PSMC5	1519.0
ITPR3	1510.0
H2AC6	1509.0
TUBA8	1505.0
APP	1473.0
SKP1	1470.0
RPL7A	1463.0
H4C4	1434.0
FNTA	1406.0
RNF213	1338.0
IFNGR2	1310.0
RPS3	1291.0
ELMO2	1279.0
KPNA2	1259.0
LIG1	1254.0
GTF2E2	1248.0
ITPR2	1217.0
HMG20B	1213.0
HLA-C	1212.0
YWHAQ	1114.0
ANO6	1091.0
KDM1A	1089.0
TAB2	1079.0
MNAT1	1066.0
GTF2H4	1040.0
KPNA3	1035.0
VPS36	1023.0
MGAT2	1019.5
RPL36AL	1019.5
POLR2B	1016.0
H3C2	1002.0
NLRP12	976.0
JAK2	952.0
RPN1	944.0
MAPK1	915.0
FKBP4	878.0
SV2A	806.0
TAF3	788.0
ST6GALNAC2	766.0
MAP2K4	749.0
ADCY9	728.0
AP2B1	724.0
TGFB1	696.0
EIF2AK2	654.0
TBL1XR1	644.0
VEGFA	633.0
DYNC1I2	583.0
RPS27L	566.0
PABPN1	485.0
RPL26L1	476.0
DPEP1	451.0
TAF13	443.0
FCGR3A	410.0
SNAP25	407.0
SUZ12	349.0
RPL6	325.0
TYK2	306.0
TUBB6	295.0
ATP1A1	278.0
TXNRD1	268.0
SDC2	259.0
XRCC4	193.0
RPS9	183.0
RAB5A	180.0
GNG4	174.0
CANX	160.0
HAVCR1	142.0
DVL2	134.0
RPS10	102.0
PSMF1	4.0
RHBDF2	-26.0
TAF10	-28.0
MYO10	-78.0
ARPC1B	-92.0
NCKAP1L	-115.0
GNB4	-125.0
CD9	-175.0
PARP14	-177.0
KPNA4	-188.0
H2BC1	-192.0
FKBP1A	-210.0
GPC6	-225.0
RPS3A	-233.0
H2BC4	-260.0
NRP1	-269.0
RPS26	-319.0
VPS37B	-333.0
EZH2	-344.0
POLR2G	-351.0
H2BC5	-354.0
CUL3	-394.0
SNRPB	-401.0
SEM1	-434.0
MGAT4A	-459.0
TAF4	-484.0
ITGA4	-497.0
BCL2L1	-528.0
ROCK2	-555.0
RPL9	-564.0
TRAF6	-626.0
HLA-G	-673.0
CDH1	-689.0
NUP35	-710.0
RAN	-745.0
RPS19	-748.0
IFNAR2	-751.0
ELL	-755.0
POLR2K	-795.0
PSMC2	-844.0
KEAP1	-855.0
STAM2	-857.0
NFKBIA	-865.0
NMI	-893.0
HLA-A	-902.0
RPS25	-928.0
SAP30L	-933.0
SNRPG	-949.0
SLC25A4	-1021.0
MAP2K3	-1030.0
RPL17	-1074.0
TAF5	-1088.0
H2AC21	-1139.0
AP1S3	-1188.0
RPS15A	-1190.0
RPL31	-1191.0
TLR2	-1307.0
NFE2L2	-1323.0
SUDS3	-1326.0
GRB2	-1330.0
VAV2	-1367.0
CCNK	-1375.0
RPL41	-1400.0
HMGA1	-1414.0
ZDHHC3	-1425.0
CCNT2	-1429.0
CRBN	-1463.0
RPL21	-1464.0
YWHAG	-1477.0
MAP3K7	-1507.0
POLR2C	-1547.0
AKT3	-1580.0
RPS28	-1593.0
SEC13	-1604.0
PRKACG	-1626.0
SUMO1	-1643.0
H3C11	-1655.0
SERPINE1	-1662.0
H4C12	-1743.0
H2BC12	-1772.0
RPS29	-1802.0
GNAS	-1823.0
GTF2A2	-1840.0
SH3GL1	-1846.0
ABL1	-1929.0
TLR1	-1972.0
GNG8	-1974.0
RPL4	-1976.0
ARF1	-1980.0
GNG12	-2009.0
PARP8	-2021.0
H2BC17	-2040.0
RPL14	-2101.0
MET	-2113.0
TAF4B	-2117.0
H2BC21	-2129.0
RPN2	-2137.0
JAK1	-2142.0
ADCY7	-2188.0
PSMD6	-2201.0
SRPK2	-2203.0
GEMIN6	-2249.0
GPS2	-2268.0
PSMD8	-2294.0
VAV3	-2312.0
LYN	-2322.0
TUBA4A	-2325.0
YES1	-2333.0
GEMIN7	-2369.0
TUBA4B	-2380.0
RPS16	-2419.0
MAN2A1	-2420.0
ANO5	-2450.0
RPS27A	-2472.0
MVB12B	-2505.0
IL17RC	-2527.0
WNT5A	-2587.0
WIPF3	-2589.0
H2AC1	-2599.0
PRKAR1B	-2606.0
PSIP1	-2714.0
ST3GAL4	-2716.0
PSMA2	-2726.0
H4C13	-2741.0
RAC1	-2752.0
SNF8	-2761.0
ARID4B	-2813.0
ADAM17	-2880.0
NCK1	-2888.0
NLRP3	-2898.0
RIPK3	-2933.0
NUP205	-3003.0
RPLP1	-3066.0
GTF2F2	-3076.0
H2BC6	-3080.0
GGT1	-3088.0
DOCK1	-3123.0
SEC24D	-3129.0
H2BC15	-3142.0
BECN1	-3180.0
PSMB4	-3191.0
TAF11	-3192.0
YWHAE	-3214.0
RPL12	-3217.0
RPL38	-3220.0
PARP6	-3228.0
H2AC20	-3235.0
PKLR	-3258.0
HSP90AA1	-3286.0
HSPG2	-3297.0
COMT	-3307.0
ST6GALNAC3	-3321.0
AP2M1	-3365.0
RPL32	-3366.0
AHCYL1	-3425.0
RPL28	-3461.0
PSMA8	-3478.0
GEMIN5	-3494.0
NUP50	-3509.0
HSPA1A	-3563.0
ZDHHC20	-3586.0
MGAT4C	-3605.0
NUP210	-3669.0
IL6	-3702.0
H2BC9	-3718.5
H3C7	-3718.5
MTA2	-3732.0
CLTA	-3747.0
IFNA5	-3827.0
HBEGF	-3838.0
RNGTT	-3846.0
SEC24B	-3858.0
ANTXR1	-3893.0
CHMP3	-3897.0
ATP1A4	-3912.0
POM121	-3922.0
VPS37C	-3928.0
TRIM27	-3949.0
PSMB10	-3966.0
TUBA1C	-3972.0
GPC5	-4096.0
RPL15	-4110.0
CBLL1	-4119.0
H2BC26	-4236.0
VTA1	-4251.0
PSMA5	-4274.0
TUBB	-4279.0
WIPF1	-4281.0
RPL29	-4307.0
TJP1	-4334.0
CTSL	-4367.0
SYT1	-4371.0
IFNA14	-4373.0
IPO5	-4399.0
H2AC25	-4404.0
ADCY1	-4407.0
GTF2B	-4430.0
SDC1	-4540.0
GJA1	-4611.0
ADCY2	-4657.0
SFN	-4660.0
ATP1A2	-4692.0
CHMP1A	-4694.0
VPS18	-4731.0
ANO3	-4733.0
PSMB6	-4786.0
HNRNPA1	-4801.0
CUL5	-4806.0
MVB12A	-4809.0
ANO1	-4872.0
ELMO1	-4914.0
DYNLL1	-4954.0
GNB5	-4967.0
RPL22L1	-5004.0
PPIB	-5006.0
ITPR1	-5018.0
SYK	-5067.0
NCOR2	-5218.0
RPS8	-5241.0
PSMB7	-5258.0
ADCY8	-5290.0
DYNC1I1	-5309.0
ERCC3	-5361.0
PARP16	-5384.0
STAM	-5412.0
IL17RA	-5414.0
CALR	-5434.0
NCKAP1	-5439.0
CDK9	-5440.0
CYFIP1	-5543.0
CHMP2B	-5574.0
RCOR1	-5587.0
FGR	-5701.0
NMT1	-5717.0
PTGES3	-5736.0
MGAT4B	-5741.0
RPSA	-5754.0
FYN	-5782.0
ERCC2	-5783.0
ADCY5	-5795.0
STX1A	-5888.0
TRIM4	-5899.0
NUP155	-5949.0
IL10	-5955.0
NOS2	-5986.0
CHMP4A	-5994.0
PRKAR2B	-6011.0
PLCG2	-6046.0
RPL34	-6070.0
TUBA3D	-6078.0
AGRN	-6085.0
GNG13	-6148.0
PSMD2	-6176.0
IL17A	-6179.0
ZDHHC11	-6205.0
SH3GL3	-6210.0
GALNT1	-6215.0
IMPDH1	-6245.0
CTNND1	-6279.0
IRAK2	-6294.0
ANO2	-6297.0
HCK	-6307.0
ATP1B1	-6338.0
ADCY4	-6452.0
H4C6	-6464.0
NOXA1	-6543.0
DVL3	-6670.0
IL1A	-6686.0
CASP1	-6717.0
UBE2N	-6780.0
TAF7	-6785.0
UBC	-6842.0
PSTPIP1	-6900.0
VPS16	-6919.0
NPM1	-6941.0
ANTXR2	-6953.0
VPS45	-6974.0
H4C2	-6995.0
C3AR1	-7054.0
TUBB4A	-7113.0
IFNA21	-7128.0
SNRPE	-7134.0
IL6R	-7164.0
WIPF2	-7227.0
RUNX1	-7252.0
IKBKE	-7451.0
MYH2	-7477.0
ITGB1	-7482.0
CYSLTR2	-7494.0
NOD1	-7516.0
RPL23	-7518.0
CCNH	-7541.0
IL18	-7581.0
TUBA3C	-7603.0
RNF135	-7633.0
ENTPD1	-7671.0
POLR2L	-7683.0
GNAI1	-7726.0
PSME1	-7763.0
SH3GL2	-7827.0
GNG10	-7898.0
RPL13A	-7929.5
EGFR	-7980.0
H3C4	-8000.0
TKFC	-8012.0
TUBB2A	-8021.0
RPS12	-8043.0
CD4	-8069.0
POM121C	-8073.0
TAF1L	-8088.0
CCR5	-8092.0
RPL23A	-8127.0
BST2	-8139.0
H2AC4	-8140.0
ANO4	-8143.0
TMPRSS2	-8173.0
TUSC3	-8180.0
H3C10	-8206.0
NEDD4L	-8238.0
IL1R1	-8298.0
TXN	-8397.0
MEFV	-8400.0
BRD4	-8512.0
MOGS	-8526.0
PSMB11	-8541.0
SMAD3	-8542.0
H2AC12	-8592.0
H2AC7	-8707.5
H2BC7	-8707.5
TUBA3E	-8723.0
FURIN	-8937.0
TUBAL3	-9053.0
H3C12	-9106.0
TAF6	-9176.0
H2AC13	-9179.0
IL17F	-9252.0
FCGR2A	-9280.0
H2BC13	-9329.0
CHMP4C	-9374.0
POLR2J	-9382.0
ENO1	-9461.0
GGT5	-9476.0
ELOA2	-9527.0
RPL10L	-9546.0
FXYD1	-9554.0
SFTPD	-9589.0
IFNA7	-9606.0
NOD2	-9647.0
STING1	-9782.0
CTSG	-9867.0
MBL2	-9921.0
FXYD2	-9980.0
IFNA2	-10019.0
TXNIP	-10089.0

---

REACTOME_TRANSLATION

REACTOME_TRANSLATION

	1152
set	REACTOME_TRANSLATION
setSize	278
pANOVA	2.83e-07
s.dist	0.179
p.adjustANOVA	3.57e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL39L	11403
GADD45GIP1	11391
MRPL4	11169
EIF3J	10922
MRPL40	10889
EIF2B5	10807
MRPL10	10746
LARS1	10662
MRPL12	10637
RPS24	10632
MRPS7	10520
MRPS31	10484
MRPL54	10410
TUFM	10261
UBA52	10169
AURKAIP1	10040
EIF3B	10018
MRPL34	9991
AARS2	9898
RPL26	9894

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL39L	11403.0
GADD45GIP1	11391.0
MRPL4	11169.0
EIF3J	10922.0
MRPL40	10889.0
EIF2B5	10807.0
MRPL10	10746.0
LARS1	10662.0
MRPL12	10637.0
RPS24	10632.0
MRPS7	10520.0
MRPS31	10484.0
MRPL54	10410.0
TUFM	10261.0
UBA52	10169.0
AURKAIP1	10040.0
EIF3B	10018.0
MRPL34	9991.0
AARS2	9898.0
RPL26	9894.0
MRPL9	9884.0
RPL27	9834.0
EIF4A1	9727.0
AIMP2	9566.0
EIF4G1	9315.0
YARS2	9093.0
SRP54	8752.0
MRPS14	8704.0
SEC61G	8671.0
DDOST	8630.0
SRPRB	8622.0
EIF2S1	8553.0
RPL10A	8486.0
MRPL15	8480.0
GSPT1	8361.0
RPS14	8357.0
MRPL57	8340.0
EIF4H	8323.0
RPL24	8299.0
EIF3D	8289.0
MRPL55	8267.0
RPS20	8266.0
IARS1	8220.0
EIF2B1	8168.0
RPS27	8146.0
MARS2	8089.0
FAU	8073.0
RPS5	8053.0
MRPS17	8052.0
TARS2	8026.0
ETF1	7992.0
RPL35	7924.0
MRPL58	7838.0
MRPL44	7709.0
YARS1	7700.0
EARS2	7676.0
RARS2	7629.0
RPL36	7593.0
MRPS11	7469.0
SRP9	7373.0
MRPL22	7320.0
MRPS15	7295.0
EEF2	7278.0
MTRF1L	7266.0
MRPS16	7182.0
MRPL49	6940.0
RPS15	6917.0
RPS7	6908.0
MRPL30	6774.0
MRPL51	6735.0
CHCHD1	6731.0
RPL22	6685.0
MRPL42	6652.0
MRPL27	6619.0
RPL37A	6589.0
SRP14	6572.0
RPL5	6546.0
HARS1	6507.0
RPS18	6474.0
EIF3G	6327.0
EEF1A1	6294.0
SRP68	6206.0
EIF5	6130.0
MRPS10	6103.0
SEC61A1	6064.0
MRPL52	5922.0
EEF1A2	5918.0
WARS2	5915.0
MRPL1	5822.0
MRPL41	5751.0
SEC11A	5743.0
MRPL48	5680.0
SSR2	5675.0
RPS6	5583.0
EIF3F	5542.0
MRPS24	5500.0
SRP19	5474.0
EIF3K	5464.0
EIF3A	5419.0
RARS1	5416.0
RPL13	5324.0
HARS2	5209.0
RPL18	5130.0
RPL11	5014.0
RPLP2	4945.0
RPL37	4942.0
PARS2	4908.0
MTIF3	4904.0
RPL7	4893.0
RPL19	4852.0
EIF5B	4837.0
APEH	4797.0
SPCS1	4735.0
RPL3L	4652.0
CARS1	4596.0
MRPS28	4570.0
EEF1D	4554.0
MRPS35	4539.0
EIF3M	4506.0
SEC61B	4500.0
NARS1	4414.0
SARS2	4404.0
SRPRA	4244.0
MRPL43	4134.0
MRPS22	4103.0
RPL8	4020.0
MRPL23	3925.0
MRPL17	3844.0
GFM2	3716.0
RPS23	3706.0
RPS13	3696.0
MRPL21	3642.0
MRPS30	3602.0
RPS11	3544.0
TARS1	3518.0
RPLP0	3496.0
EEF1B2	3476.0
EIF4EBP1	3433.0
MRPL16	3428.0
VARS2	3383.0
MRPL47	3362.0
MARS1	3321.0
EIF4E	3219.0
MRPS34	3177.0
CARS2	3144.0
EIF2B4	3134.0
SPCS3	3107.0
TRMT112	2809.0
KARS1	2734.0
NARS2	2717.0
EIF2B2	2599.0
ERAL1	2566.0
MRPL38	2550.0
RPL27A	2534.0
RPS21	2412.0
EIF4B	2411.0
RPL30	2387.0
MTFMT	2304.0
PTCD3	2301.0
MRPL14	2278.0
RPL35A	2255.0
DARS1	2136.0
MRPS12	2131.0
RPS2	2069.0
RPL3	2052.0
MRPS18A	2038.0
DAP3	1914.0
IARS2	1891.0
MRPL32	1873.0
RPL18A	1823.0
EIF3E	1822.0
PPA2	1684.0
RPL7A	1463.0
MRPL46	1395.0
N6AMT1	1319.0
RPS3	1291.0
MRPL39	1216.0
WARS1	1031.0
RPL36AL	1019.5
MRPS27	1000.0
RPN1	944.0
OXA1L	869.0
EIF3L	803.0
MRPS26	613.0
MRPL20	585.0
RPS27L	566.0
MRPL24	526.0
RPL26L1	476.0
SRP72	463.0
MRRF	457.0
PPA1	438.0
AARS1	364.0
RPL6	325.0
RPS9	183.0
MRPL19	166.0
RPS10	102.0
FARSA	-161.0
RPS3A	-233.0
RPS26	-319.0
EIF2S2	-483.0
RPL9	-564.0
FARSB	-588.0
GARS1	-683.0
EPRS1	-737.0
MRPS25	-744.0
RPS19	-748.0
RPS25	-928.0
PABPC1	-955.0
MRPS18B	-1059.0
RPL17	-1074.0
GFM1	-1186.0
RPS15A	-1190.0
RPL31	-1191.0
MRPS2	-1199.0
VARS1	-1336.0
SSR1	-1346.0
RPL41	-1400.0
RPL21	-1464.0
RPS28	-1593.0
LARS2	-1646.0
AIMP1	-1683.0
TRAM1	-1725.0
RPS29	-1802.0
RPL4	-1976.0
SPCS2	-1988.0
RPL14	-2101.0
RPN2	-2137.0
EIF3H	-2182.0
EIF2B3	-2212.0
FARS2	-2273.0
MRPL50	-2416.0
RPS16	-2419.0
RPS27A	-2472.0
MRPS9	-2641.0
MRPL18	-2783.0
RPLP1	-3066.0
RPL12	-3217.0
RPL38	-3220.0
RPL32	-3366.0
RPL28	-3461.0
MRPL13	-3818.0
MRPL28	-4038.0
MRPS23	-4107.0
RPL15	-4110.0
MRPL11	-4132.0
MTIF2	-4231.0
RPL29	-4307.0
DARS2	-4313.0
MRPL36	-4376.0
SEC61A2	-4521.0
EIF3I	-4555.0
RPL22L1	-5004.0
MRPL37	-5161.0
RPS8	-5241.0
MRPS33	-5348.0
MRPL53	-5448.0
RPSA	-5754.0
EEF1E1	-5831.0
TSFM	-5889.0
SSR3	-5901.0
MRPL45	-6006.0
RPL34	-6070.0
EIF4A2	-6271.0
SEC11C	-6758.0
MRPL3	-6857.0
MRPS6	-6874.0
EEF1G	-6875.0
MRPL33	-6970.0
MRPS5	-7118.0
MRPL2	-7391.0
RPL23	-7518.0
MRPS18C	-7600.0
RPL13A	-7929.5
RPS12	-8043.0
RPL23A	-8127.0
MRPL35	-8209.0
MRPS21	-8527.0
RPL10L	-9546.0

---

REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

	1082
set	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE
setSize	125
pANOVA	3.38e-07
s.dist	-0.264
p.adjustANOVA	3.96e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KRT17	-10182
SPRR2E	-10134
LCE3D	-9941
LIPN	-9929
KRT82	-9875
KRT71	-9807
KRT37	-9764
CSTA	-9499
LCE1B	-9380
LCE3E	-9310
KRT4	-9237
LCE2B	-9107
FLG	-9083
KRT76	-9073
KRT33B	-9047
KRT26	-9036
FURIN	-8937
KRT75	-8815
SPRR1B	-8770
KLK8	-8653

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KRT17	-10182
SPRR2E	-10134
LCE3D	-9941
LIPN	-9929
KRT82	-9875
KRT71	-9807
KRT37	-9764
CSTA	-9499
LCE1B	-9380
LCE3E	-9310
KRT4	-9237
LCE2B	-9107
FLG	-9083
KRT76	-9073
KRT33B	-9047
KRT26	-9036
FURIN	-8937
KRT75	-8815
SPRR1B	-8770
KLK8	-8653
SPRR3	-8621
LCE1A	-8504
KRT28	-8484
SPRR2G	-8469
KRT25	-8432
KRT38	-8395
KRT40	-8371
LCE5A	-8282
KRT83	-8213
KRT23	-8134
KRT36	-7921
KRT32	-7862
KRT35	-7861
KRT84	-7812
KRT39	-7790
LCE1E	-7719
DSC3	-7711
KRT2	-7689
LCE3B	-7667
LCE1C	-7592
KRT81	-7571
KRT86	-7532
KRT18	-7317
TGM1	-6675
KRT77	-6634
LIPJ	-6514
IVL	-6496
KRT7	-6404
KRT5	-6397
DSG3	-6381
KRT6B	-6258
DSG4	-6155
KRT74	-5992
JUP	-5938
KRT72	-5465
KRT24	-4945
CASP14	-4823
KAZN	-4716
TGM5	-4605
ST14	-4465
DSC2	-4413
KRT80	-4243
PCSK6	-3887
KRT85	-3226
KRT31	-2892
KRT78	-2826
SPRR2F	-2050
TCHH	-2010
PI3	-1985
PERP	-1563
CAPNS1	-1294
KRT1	-1195
CDSN	-1012
KRT3	-985
LCE6A	-832
CELA2A	-813
SPINK5	-777
KRT20	84
KRT33A	173
LCE1F	228
PRSS8	547
DSP	687
SPRR2A	708
PKP2	968
PKP3	1188
KRT79	1196
KRT6C	1294
SPRR2D	1356
DSG1	1747
KLK14	1983
KRT15	1988
DSG2	2032
LIPK	2563
KRT9	2624
RPTN	2772
SPRR1A	3302
LCE2A	4078
KRT12	4200
KRT27	4351
PPL	4930
EVPL	5063
KRT10	5086
SPINK6	5100
KRT16	5158
LCE4A	5469
KLK5	6051
PKP4	6125
KRT6A	6384
KLK12	6913
CAPN1	7465
LCE2C	8509
LCE2D	8590
SPINK9	8652
LIPM	8674
KRT13	8967
PKP1	9133
LELP1	9165
KRT8	9177
KRT34	9616
KRT19	9928
KRT73	9988
LCE3A	10151
DSC1	10542
KLK13	10584
KRT14	10844

---

REACTOME_CHROMATIN_MODIFYING_ENZYMES

REACTOME_CHROMATIN_MODIFYING_ENZYMES

	558
set	REACTOME_CHROMATIN_MODIFYING_ENZYMES
setSize	252
pANOVA	5.82e-07
s.dist	0.183
p.adjustANOVA	6.37e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
KMT2B	11327
H2AC14	11207
SMARCA4	10798
H2BC3	10676
H3C3	10604
TADA1	10583
PRMT5	10556
MTA3	10531
TADA2B	10501
HDAC10	10397
MEAF6	10219
KDM5A	10205
H3C8	10202
USP22	10127
EP400	10070
TAF12	10008
KDM2A	9941
BRMS1	9660
PAX3	9656
H2BC14	9533

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
KMT2B	11327.0
H2AC14	11207.0
SMARCA4	10798.0
H2BC3	10676.0
H3C3	10604.0
TADA1	10583.0
PRMT5	10556.0
MTA3	10531.0
TADA2B	10501.0
HDAC10	10397.0
MEAF6	10219.0
KDM5A	10205.0
H3C8	10202.0
USP22	10127.0
EP400	10070.0
TAF12	10008.0
KDM2A	9941.0
BRMS1	9660.0
PAX3	9656.0
H2BC14	9533.0
MSL1	9415.0
WDR77	9377.0
H4C16	9262.0
H4C11	9253.0
KDM4A	9224.0
BRPF1	9147.0
SUV39H2	9087.0
SETD3	9009.0
H4C8	9007.0
KDM3B	8933.0
GATAD2B	8932.0
KMT5C	8847.0
ACTB	8836.0
ZZZ3	8769.0
H2AZ1	8737.0
HDAC3	8661.0
RELA	8623.0
SETD1B	8620.0
CREBBP	8505.0
H2AC16	8457.0
CHD3	8412.0
H2AC8	8407.0
KDM4B	8392.0
SAP130	8298.0
SMARCC1	8285.0
CHD4	8242.0
REST	8214.0
SMARCB1	8185.0
SMARCC2	8155.0
HAT1	8144.0
RBBP5	8079.0
TAF5L	7913.0
DOT1L	7896.0
PADI3	7818.0
H4C5	7742.0
PBRM1	7734.0
TADA3	7721.0
SETD7	7701.0
HDAC1	7688.0
KMT2D	7592.0
CDK4	7586.0
MBIP	7518.0
H2BC10	7509.0
CARM1	7482.0
KAT7	7432.0
JADE1	7339.0
H2AC17	7258.0
RUVBL2	7250.0
KMT2A	7072.0
TAF9	6942.0
ACTL6A	6941.0
H4C3	6897.0
KDM7A	6808.0
BRWD1	6668.0
NFKB1	6611.0
PHF2	6520.0
HDAC2	6444.0
EPC1	6402.0
KMT5B	6344.0
PADI6	6253.0
SETD2	6221.0
NCOR1	6071.0
WDR5	5961.0
H2AC11	5849.0
PRMT3	5841.0
H4C9	5774.0
MSL2	5755.0
SAP30	5739.0
GATAD2A	5722.0
EP300	5668.0
NSD3	5595.0
ATF2	5532.0
KAT6B	5467.0
SETD1A	5361.0
KDM2B	5294.0
MCRS1	5265.0
SETDB1	5217.0
PHF20	5189.0
H2AC18	5121.5
H2AC19	5121.5
EED	5078.0
H2BC8	5070.0
PADI2	5038.0
ARID4A	5020.0
NSD2	4961.0
H2AC15	4918.0
KDM5B	4754.0
MTA1	4534.0
KAT2A	4523.0
DMAP1	4391.0
H3C1	4153.0
ELP5	4060.0
H2BC11	4044.0
NFKB2	4022.0
RBBP4	3906.0
ELP2	3876.0
COPRS	3821.0
PRMT1	3725.0
ELP6	3675.0
MBD3	3615.0
AEBP2	3489.0
KDM3A	3401.0
CLOCK	3329.0
KMT2C	3189.0
MRGBP	3164.0
H3C6	3151.0
H2AX	3086.0
SMARCD1	3080.0
TADA2A	3057.0
TAF6L	3023.0
PHF21A	2921.0
SGF29	2644.0
ARID2	2584.0
ATXN7L3	2471.0
ELP1	2441.0
SMARCE1	2388.0
BRD8	2382.0
SAP18	2286.0
H4C1	2273.0
PRMT7	2264.0
DNMT3A	2244.0
MORF4L1	2162.0
RPS2	2069.0
BRPF3	2008.0
JADE2	1955.0
SMYD2	1940.0
CCND1	1840.0
SETDB2	1718.0
KDM4C	1695.0
MECOM	1613.0
ARID1B	1602.0
ELP3	1591.0
EHMT2	1533.0
H2AC6	1509.0
SMARCD3	1435.0
H4C4	1434.0
KANSL1	1325.0
TRRAP	1239.0
HMG20B	1213.0
KDM1A	1089.0
KDM6B	1017.0
H3C2	1002.0
JAK2	952.0
ATXN7	886.0
ING5	838.0
KANSL2	814.0
KDM1B	672.0
TBL1XR1	644.0
PRMT6	602.0
NSD1	415.0
SUZ12	349.0
KMT5A	190.0
ARID1A	189.0
ASH1L	150.0
KMT2E	148.0
NCOA1	37.0
TAF10	-28.0
SUPT20H	-101.0
ASH2L	-118.0
VPS72	-144.0
H2BC1	-192.0
H2BC4	-260.0
PADI4	-276.0
EHMT1	-280.0
ENY2	-342.0
EZH2	-344.0
H2BC5	-354.0
BRD1	-440.0
YEATS2	-472.0
KANSL3	-711.0
SUPT7L	-824.0
SMARCA2	-856.0
SAP30L	-933.0
JMJD6	-993.0
SETD6	-999.0
DPY30	-1108.0
H2AC21	-1139.0
KAT6A	-1324.0
SUDS3	-1326.0
H3C11	-1655.0
H4C12	-1743.0
H2BC12	-1772.0
H2BC17	-2040.0
H2BC21	-2129.0
NCOA2	-2231.0
GPS2	-2268.0
SMARCD2	-2447.0
H2AC1	-2599.0
H4C13	-2741.0
ARID4B	-2813.0
ING4	-2859.0
H2BC6	-3080.0
H2BC15	-3142.0
H2AC20	-3235.0
PADI1	-3369.0
H2AZ2	-3381.0
DR1	-3480.0
ELP4	-3499.0
KAT2B	-3652.0
KDM4D	-3688.0
H2BC9	-3718.5
H3C7	-3718.5
MTA2	-3732.0
YEATS4	-3918.0
SUPT3H	-4201.0
H2BC26	-4236.0
PRDM9	-4403.0
H2AC25	-4404.0
KAT5	-4633.0
ACTL6B	-5120.0
NCOR2	-5218.0
RCOR1	-5587.0
RIOX2	-6013.0
H2AJ	-6028.0
ING3	-6348.0
RUVBL1	-6422.0
H4C6	-6464.0
PRDM16	-6556.0
H4C2	-6995.0
SMYD3	-7122.0
KAT8	-7563.0
ARID5B	-7698.0
H3C4	-8000.0
H2AC4	-8140.0
H3C10	-8206.0
H2AC12	-8592.0
H2AC7	-8707.5
H2BC7	-8707.5
ATF7IP	-8818.0
H3C12	-9106.0
H2AC13	-9179.0
H2BC13	-9329.0

---

REACTOME_SENSORY_PERCEPTION

REACTOME_SENSORY_PERCEPTION

	1581
set	REACTOME_SENSORY_PERCEPTION
setSize	555
pANOVA	7.94e-07
s.dist	-0.123
p.adjustANOVA	8.15e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
OR2S2	-10171
OR52E6	-10079
OR5T3	-10074
TAS2R39	-10042
OR52L1	-9971
OR52K2	-9914
OR4D11	-9851
OR10AG1	-9837
OR2V2	-9835
OR10G8	-9831
OR10H3	-9826
OR51F2	-9810
OR1S2	-9798
OR5M10	-9756
OR5B21	-9727
OR5C1	-9722
OR5M3	-9718
OR4K15	-9709
OR5B17	-9682
OR2L5	-9676

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
OR2S2	-10171.0
OR52E6	-10079.0
OR5T3	-10074.0
TAS2R39	-10042.0
OR52L1	-9971.0
OR52K2	-9914.0
OR4D11	-9851.0
OR10AG1	-9837.0
OR2V2	-9835.0
OR10G8	-9831.0
OR10H3	-9826.0
OR51F2	-9810.0
OR1S2	-9798.0
OR5M10	-9756.0
OR5B21	-9727.0
OR5C1	-9722.0
OR5M3	-9718.0
OR4K15	-9709.0
OR5B17	-9682.0
OR2L5	-9676.0
OR4C16	-9673.0
OR6Q1	-9662.0
OR1F1	-9657.0
OR6B3	-9645.0
OR5AC2	-9638.0
OR6N1	-9636.0
OR10AD1	-9632.0
OR2V1	-9619.0
OR56B4	-9591.0
OR5P3	-9582.0
OR51T1	-9576.0
OPN1SW	-9556.0
OR5I1	-9525.0
OR1A1	-9518.0
OR2AT4	-9517.0
OR5A2	-9516.0
OR10G7	-9513.0
OR8I2	-9501.0
OR52E4	-9468.0
OR4K13	-9439.0
OR7C1	-9416.0
OR5J2	-9413.0
OR51E1	-9410.0
OR10A3	-9314.0
OR10J3	-9303.0
OR14J1	-9257.0
OR5A1	-9216.0
TAS2R41	-9196.0
OR5D18	-9181.0
RBP3	-9166.0
OR52J3	-9141.0
TAS2R20	-9109.0
OR51B4	-9099.0
OR6M1	-9085.0
OR7G2	-9081.0
OR7E24	-9052.0
OR4A5	-9032.0
OR8B4	-9028.0
OR4F15	-9021.0
OR51D1	-9001.0
OR9I1	-8995.0
OR7G3	-8989.0
PCDH15	-8972.0
OR13C4	-8947.0
OR11A1	-8928.0
OR9G4	-8918.0
OR6C74	-8907.0
OR52I1	-8898.0
OR2M4	-8877.0
OR1L3	-8872.0
OR5M8	-8806.0
OR2G3	-8800.0
OR14A16	-8777.0
OR12D3	-8724.0
OR4D5	-8690.0
OR10G4	-8606.0
OR51I2	-8589.0
APOC2	-8552.0
OR4X1	-8545.0
OR5H6	-8501.0
TAS1R3	-8474.0
OR7D4	-8458.0
OR5M11	-8445.0
OR5AS1	-8402.0
LRP12	-8381.0
OR2A12	-8353.0
OR8K1	-8346.0
OR6T1	-8331.0
OR4N2	-8280.0
OR9Q1	-8245.0
OR1L8	-8189.0
OR2T6	-8151.0
OR51B2	-8132.0
OR8D4	-8110.0
OR8U8	-8103.0
OR4E2	-8081.0
TAS2R4	-8079.0
OR52N1	-8017.0
PNLIP	-8009.0
OR8B12	-7982.0
TAS2R5	-7968.0
OR8K5	-7956.0
CHRNA9	-7884.0
OR2F2	-7789.0
OR51F1	-7718.0
OR5AK2	-7678.0
OR8U3	-7669.0
OR8D1	-7626.0
PDE6A	-7620.0
OR8K3	-7610.0
OR6C68	-7456.0
OR13D1	-7437.0
TTR	-7413.0
OR1B1	-7301.0
ABCA4	-7274.0
OR6C65	-7219.0
EPB41L3	-7202.0
RCVRN	-7199.0
RBP4	-7193.0
OR56A3	-7182.0
OR9Q2	-7139.0
OR13C9	-7124.0
APOA2	-7112.0
OR6F1	-7110.0
OR2K2	-7088.0
PCLO	-7086.0
OR51A2	-7072.0
RBP2	-7001.0
OR2H2	-6943.0
OR6B2	-6920.0
OR5L1	-6892.0
RLBP1	-6877.0
OR10A6	-6831.0
SCN3A	-6825.0
LDLR	-6795.0
OR11L1	-6682.0
BSN	-6535.0
OR6P1	-6505.0
ANO2	-6297.0
APOB	-6247.0
TMC1	-6240.0
DHRS3	-6225.0
OR2T8	-6208.0
GSN	-6193.0
EBF1	-6187.0
OR2A2	-6172.0
TAS2R40	-6156.0
GNG13	-6148.0
AGRN	-6085.0
OR5F1	-6009.0
ESPN	-5985.0
OR1M1	-5979.0
OR51B6	-5909.0
STX1A	-5888.0
KCNMA1	-5801.0
TAS2R16	-5773.0
TAS2R1	-5770.0
OR8J1	-5740.0
NMT1	-5717.0
OR2H1	-5650.0
MYO15A	-5635.0
OR8U1	-5631.0
OR5B12	-5609.0
OR2T3	-5604.0
OR1N1	-5591.0
GRXCR1	-5521.0
GRK1	-5474.0
OR4K1	-5447.0
OR51Q1	-5424.0
OR5M9	-5417.0
OR5K3	-5366.0
OR5K1	-5364.0
OR2C3	-5342.0
OR6C1	-5338.0
OR2Z1	-5296.0
OR13C2	-5219.0
OR10K1	-5131.0
OR10H2	-5107.0
OR8D2	-5098.0
OR52A5	-5085.0
OR8H3	-5063.0
OR5B3	-4984.0
OR4A16	-4980.0
GNB5	-4967.0
OR2W3	-4962.0
RTP2	-4942.0
OR10S1	-4937.0
OR4C3	-4935.0
OR51L1	-4844.0
OR4D6	-4838.0
PLCB2	-4803.0
OR2C1	-4709.0
OR13G1	-4665.0
OR2Y1	-4609.0
SDC1	-4540.0
OTOGL	-4537.0
OR52W1	-4508.0
OR51G1	-4506.0
OR8B2	-4484.0
OR5V1	-4473.0
OR2D3	-4425.0
AKR1C1	-4393.0
CACNB2	-4300.0
OR8S1	-4284.0
OR5D14	-4098.0
GPC5	-4096.0
MYO3B	-4077.0
KCNJ2	-4062.0
OR5T1	-4021.0
OR13C3	-4007.0
OR1L1	-3994.0
OR51S1	-3964.0
TAS2R46	-3954.0
OR1Q1	-3946.0
OR5H2	-3929.0
OR4F6	-3886.0
OR52B6	-3877.0
CAPZB	-3829.0
WHRN	-3817.0
OR56A4	-3755.0
OR13F1	-3735.0
GRXCR2	-3662.0
XIRP2	-3608.0
OR5AU1	-3535.0
OR4M1	-3504.0
RDX	-3488.0
OR52M1	-3456.0
OR51V1	-3408.0
OR51E2	-3373.0
CLIC5	-3367.0
OR1K1	-3348.0
HSPG2	-3297.0
OR51A7	-3177.0
OR1C1	-3171.0
CAPZA1	-3166.0
CAPZA2	-3094.0
LRP2	-3013.0
OR2L2	-2975.0
EPS8	-2931.0
TRPM5	-2879.0
REEP1	-2809.0
HSD17B1	-2805.0
OR2F1	-2796.0
OR10A5	-2735.0
OTOG	-2681.0
SCNN1A	-2662.0
OR5AP2	-2656.0
OR7C2	-2555.0
APOA4	-2521.0
RPE65	-2508.0
RBP1	-2501.0
GRM4	-2482.0
OR5M1	-2449.0
OTOF	-2353.0
RHO	-2349.0
RGS9	-2347.0
OR9A4	-2336.0
SCN2B	-2309.0
PDE6B	-2270.0
CACNA1D	-2004.0
OR6B1	-1919.0
OR2B2	-1824.0
OR4A47	-1774.0
EZR	-1756.0
OR6X1	-1697.0
OR9G1	-1653.5
OR9G9	-1653.5
OR7A17	-1605.0
OR6C76	-1603.0
CABP2	-1567.0
OR4A15	-1380.0
OR5P2	-1293.0
STRA6	-1269.0
OR7A10	-1250.0
OR10G2	-1224.0
SCN9A	-1145.0
OR4C6	-1051.0
CTBP2	-973.0
OR2L13	-921.0
CYP4V2	-907.0
OR2B3	-853.0
OR2B11	-817.0
OR4K17	-797.0
OR2T1	-728.0
LRP8	-715.0
OR5W2	-636.0
OR10C1	-593.0
PRKCA	-589.0
OR2T33	-569.0
CACNA2D2	-545.0
CAMKMT	-503.0
MYO3A	-495.0
ATP2B2	-279.0
GPC6	-225.0
SCNN1B	-221.0
GRM1	-79.0
TAS2R8	-60.0
OR4B1	19.0
OR10H4	41.0
LHX2	65.0
OR52I2	66.0
OR2AK2	69.0
DHRS9	113.0
TWF1	145.0
TAS1R2	212.0
OR2D2	238.0
SDC2	259.0
OR2T27	284.0
OR5K4	322.0
OR6C4	329.0
SLC24A1	361.0
TMC2	369.0
OR5D13	396.0
SNAP25	407.0
OR5B2	581.0
OR5D16	593.0
TAS2R30	603.0
GRK4	628.0
OR52K1	636.0
SPTAN1	668.0
OR51I1	690.0
EPB41L1	746.0
OR1L4	972.0
APOA1	983.0
OR51B5	1074.0
OR13C8	1129.0
LRAT	1270.0
APOC3	1289.0
OR10G3	1353.0
GNAT1	1362.0
KCNN2	1370.0
OR52H1	1399.0
FNTA	1406.0
GPIHBP1	1414.0
OR4S1	1429.0
TAS2R7	1436.0
ITPR3	1510.0
RDH10	1525.0
TAS2R43	1539.0
CALHM3	1550.0
OR7D2	1712.0
RAB3A	1751.0
SCN2A	1786.0
CNGA1	1837.0
GNB1	1912.0
SDC4	1931.0
CHRNA10	2060.0
CNGA4	2089.0
SPTBN1	2163.0
SCNN1D	2201.0
APOE	2205.0
GNAT3	2243.0
OR52B2	2267.0
OR10H5	2336.0
RDH12	2351.0
OR5T2	2380.0
SDC3	2435.0
PRKCQ	2519.0
OR10Q1	2522.0
OR2M2	2524.0
GPC1	2591.0
USH1C	2596.0
OR1G1	2609.0
OR52E8	2695.0
OR1L6	2710.0
OR6C70	2713.0
TRIOBP	2756.0
APOM	2785.0
CNGB1	2821.0
OR10A2	2847.0
OR1J4	3050.0
RTP1	3070.0
GUCY2D	3124.0
SLC26A5	3163.0
ESPNL	3217.0
OR4C15	3218.0
OR8H1	3349.0
TWF2	3402.0
KCNQ4	3446.0
OR9A2	3532.0
OR52R1	3558.0
OR1E2	3744.0
OR1D2	3751.0
GUCA1B	3768.0
OR10J1	3792.0
OR1S1	3841.0
OR6K3	3895.0
BCO2	3904.0
OR5AN1	3940.0
OR52N2	3946.0
OR12D2	3953.0
OR2A14	3990.0
CABP1	4011.0
TAS2R10	4028.0
FNTB	4031.0
BCO1	4085.0
AKR1B10	4151.0
OR1E1	4198.0
OR5H1	4201.0
METAP2	4210.0
OR9K2	4211.0
OR5L2	4250.0
MYO1C	4280.0
RGS9BP	4316.0
OR52A1	4401.0
CDH23	4516.0
OR4C46	4521.0
OTOP1	4644.0
TAS1R1	4708.0
OR6C6	4770.0
PLS1	4907.0
RETSAT	4967.0
MYH9	4989.0
CALM1	5021.0
MYO7A	5098.0
OR11G2	5195.0
SCN4B	5222.0
OR8B8	5235.0
OR3A3	5264.0
RDH8	5285.0
OR2AG1	5329.0
LPL	5333.0
OR1A2	5336.0
GNAL	5358.0
OR2T11	5399.0
GRK7	5510.0
OR5AR1	5631.0
SDR9C7	5655.0
OR5K2	5673.0
RIPOR2	5697.0
OR6C75	5703.0
OR4N5	5708.0
OR8G1	5757.0
OR4K2	5850.0
OR10X1	5891.0
OR2AP1	5967.0
OR7G1	5974.0
OR3A2	5991.0
TAS2R14	6050.0
NAPEPLD	6081.0
TRPM4	6085.0
PJVK	6097.0
OR8A1	6187.0
OR2L8	6353.0
LRP1	6355.0
ADCY3	6370.0
SCN1B	6381.0
TPRN	6469.0
CLPS	6500.0
OR1N2	6676.0
OR6K2	6718.0
GUCA1C	6738.0
OR14C36	6790.0
METAP1	6809.0
TAS2R3	6817.0
OR2J2	6849.0
OR6K6	6883.0
OR6Y1	7007.0
OR51G2	7115.0
OR51M1	7218.0
OR1J2	7293.0
USH1G	7453.0
PLB1	7560.0
OR10Z1	7611.0
OR2A5	7635.0
OR4L1	7651.0
AKR1C4	7666.0
OR10H1	7697.0
OR1I1	7879.0
TAS2R50	7906.0
NMT2	7911.0
OR11H6	7978.0
RDH16	8019.0
SCNN1G	8031.0
ATP2B1	8095.0
TAS2R38	8138.0
OR10W1	8174.0
RDH11	8253.0
SLC17A8	8307.0
LDB1	8308.0
LRP10	8314.0
EPS8L2	8318.0
GPC2	8334.0
OR52D1	8394.0
OR2W1	8523.0
OR6C3	8682.0
OR13J1	8688.0
GUCA1A	8706.0
ACTG1	8780.0
ACTB	8836.0
OR4X2	8978.0
OR4K5	9040.0
CIB2	9126.0
OR3A1	9127.0
OR6V1	9130.0
OR4C45	9176.0
OR2M7	9214.0
PDE6G	9236.0
OR8J3	9246.0
OR10J5	9344.0
OR10G9	9390.0
VAMP2	9416.0
AKR1C3	9438.0
FSCN2	9469.0
OR13A1	9485.0
OR56A1	9563.0
OR56B1	9569.0
OR7A5	9645.0
OR6A2	9707.0
OR2M3	9859.0
LHFPL5	9933.0
OR10K2	10072.0
OR10V1	10090.0
KCNMB1	10129.0
OR4D10	10135.0
TMIE	10138.0
OR2L3	10144.0
OR4D2	10211.0
DNAJC5	10295.0
OR4C12	10313.0
LRRC52	10337.0
OR1J1	10429.0
CALHM1	10493.0
OR14I1	10571.0
OR6N2	10582.0
OR56A5	10645.0
OR2AE1	10656.0
OR2B6	10684.0
OR11H4	10714.0
OR52E2	10720.0
OR4D1	10778.0
HSD17B6	10828.0
OR10A7	10853.0
STRC	10909.0
OR2T4	10920.0
OR5H15	10934.0
OR6C2	10990.0
OR10A4	11067.0
OR2G2	11166.0
SAG	11184.0
OR2AG2	11198.0
OR6S1	11245.0
OR4K14	11340.0
GNB3	11378.0
RDH5	11400.0
OR2G6	11412.0
TAS2R31	11514.0
OR2M5	11516.0
OR2T12	11550.0
OR8G5	11592.0
TAS2R13	11619.0
OR10P1	11626.0
GNGT1	11651.0
OR10T2	11732.0
OR4D9	11774.0

---

REACTOME_M_PHASE

REACTOME_M_PHASE

	1096
set	REACTOME_M_PHASE
setSize	398
pANOVA	1.18e-06
s.dist	0.142
p.adjustANOVA	0.000114

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MZT2A	11630
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
H2AC14	11207
DYNC1LI2	11173
PSMD3	11142
NUP37	10891
NSL1	10890
KIF23	10843
PPP2R5D	10754
H2BC3	10676
RCC2	10660
HAUS6	10657
H3C3	10604
NCAPG	10503
SIRT2	10431
ANKLE2	10427
PSMC1	10399

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MZT2A	11630.0
TUBB8	11383.0
TUBB1	11311.0
DYNLL2	11280.0
MAPRE1	11267.0
H2AC14	11207.0
DYNC1LI2	11173.0
PSMD3	11142.0
NUP37	10891.0
NSL1	10890.0
KIF23	10843.0
PPP2R5D	10754.0
H2BC3	10676.0
RCC2	10660.0
HAUS6	10657.0
H3C3	10604.0
NCAPG	10503.0
SIRT2	10431.0
ANKLE2	10427.0
PSMC1	10399.0
HAUS8	10351.0
UBE2I	10324.0
TUBG1	10274.0
H3C8	10202.0
CCNB2	10190.0
PSMB1	10173.0
UBA52	10169.0
B9D2	10123.0
NUP85	10105.0
NUMA1	10088.0
PSMC6	9892.0
ZW10	9885.0
CDC23	9833.0
LMNA	9748.0
XPO1	9708.0
H2BC14	9533.0
CCNB1	9488.0
RAB1A	9448.0
BUB1B	9436.0
CEP192	9411.0
PPP2R5A	9306.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
CSNK2A1	9219.0
H4C8	9007.0
CEP250	9005.0
SEH1L	8981.0
KPNB1	8882.0
KIF20A	8767.0
H2AZ1	8737.0
PSME3	8732.0
CENPF	8713.0
BIRC5	8644.0
SFI1	8531.0
CTDNEP1	8494.0
TUBA1B	8427.0
H2AC8	8407.0
ANAPC10	8406.0
PSMD13	8389.0
KIF2A	8369.0
TUBGCP2	8356.0
NUP88	8287.0
NUP42	8255.0
CHMP7	8148.0
RPS27	8146.0
PCM1	7980.0
ZWILCH	7966.0
PRKACA	7965.0
TUBGCP6	7958.0
PSMC3	7956.0
NINL	7898.0
CHMP4B	7852.0
GORASP2	7847.0
NUP62	7784.0
H4C5	7742.0
CENPJ	7729.0
PSMA3	7703.0
DYNC1H1	7672.0
CEP76	7665.0
AKAP9	7637.0
CENPC	7578.0
KNL1	7549.0
H2BC10	7509.0
CCP110	7454.0
TPR	7435.0
TAOK1	7414.0
LEMD3	7365.0
PSMD7	7334.0
RANBP2	7289.0
PDS5A	7273.0
MASTL	7138.0
CEP152	7035.0
NUP93	6988.0
EML4	6970.0
PSMA7	6898.0
H4C3	6897.0
HAUS2	6862.0
PSMA1	6861.0
NUP214	6722.0
MAU2	6663.0
PSMB2	6549.0
BANF1	6504.0
PSMC4	6484.0
KIF2C	6395.0
RAE1	6386.0
UBB	6377.0
CDC16	6332.0
CDK1	6313.0
CENPO	6310.0
CNTRL	6286.0
PCNT	6271.0
NUP153	6267.0
PSMD9	6250.0
TUBB4B	6227.0
DCTN1	6189.0
CEP57	6168.0
KIF18A	6129.0
NUP188	6088.0
TUBB2B	6024.0
PPP2R5B	6021.0
CENPK	6007.0
SMC2	6000.0
ITGB3BP	5989.0
PSMD14	5956.0
MZT2B	5904.0
NUP54	5830.0
H4C9	5774.0
PSMA6	5773.0
RANGAP1	5723.0
HAUS5	5711.0
RB1	5689.0
CHMP2A	5566.0
TUBG2	5534.0
CDCA5	5505.0
NUP133	5499.0
TUBA1A	5468.0
PSME2	5380.0
PSMD11	5320.0
UBE2S	5276.0
CSNK1D	5214.0
ARPP19	5206.0
TUBGCP3	5178.0
CDC26	5157.0
H2AC18	5121.5
H2AC19	5121.5
ANAPC1	5092.0
H2BC8	5070.0
PSMB5	5052.0
PLK4	5013.0
SPAST	4952.0
NUP58	4880.0
IST1	4868.0
PSMB3	4835.0
PPP2R1B	4800.0
LPIN3	4771.0
AAAS	4718.0
SDCCAG8	4662.0
CENPP	4572.0
AURKB	4455.0
DYNC1LI1	4367.0
NUF2	4365.0
DCTN3	4358.0
NUP107	4332.0
NDEL1	4296.0
NDC1	4258.0
PMF1	4252.0
PSME4	4171.0
H3C1	4153.0
MAD1L1	4118.0
PPP2R5C	4099.0
H3-3A	4052.0
H2BC11	4044.0
CEP41	3962.0
PSMD12	3928.0
ANAPC7	3809.0
TUBB3	3788.0
NEDD1	3782.0
CSNK2B	3763.0
CENPU	3739.0
PSMD5	3711.0
NCAPG2	3707.0
PSMB8	3681.0
PSMA4	3640.0
MIS12	3486.0
CHMP6	3463.0
RCC1	3413.0
ANAPC5	3355.0
ANAPC4	3312.0
INCENP	3298.0
MAD2L1	3280.0
BUB3	3260.0
STAG1	3161.0
PRKCB	3154.0
H3C6	3151.0
H2AX	3086.0
PSMD1	3063.0
MZT1	3049.0
CEP43	3035.0
CC2D1B	2982.0
CNEP1R1	2920.0
RAD21	2837.0
NUP43	2770.0
CKAP5	2726.0
RAB1B	2714.0
CDC27	2701.0
LPIN2	2646.0
HAUS4	2636.0
SMC3	2481.0
CLASP1	2462.0
NUP98	2445.0
GOLGA2	2395.0
NIPBL	2366.0
PPP2R5E	2327.0
PSMB9	2322.0
NCAPD3	2318.0
ALMS1	2281.0
PDS5B	2276.0
H4C1	2273.0
VPS4A	2225.0
MAPK3	2077.0
NUP160	2051.0
ZWINT	2046.0
ANAPC2	1989.0
NDC80	1973.0
NCAPD2	1923.0
SSNA1	1783.0
KNTC1	1764.0
PLK1	1754.0
NEK6	1744.0
CDCA8	1598.0
PPP2R2D	1578.0
DSN1	1571.0
PSMC5	1519.0
H2AC6	1509.0
TUBA8	1505.0
H4C4	1434.0
BUB1	1430.0
FBXO5	1384.0
UBE2D1	1355.0
PPP2CA	1345.0
ACTR1A	1341.0
PAFAH1B1	1262.0
H3C2	1002.0
WAPL	929.0
MAPK1	915.0
ODF2	864.0
H3-3B	859.0
PPP2R1A	849.0
CSNK2A2	723.0
MCPH1	680.0
NCAPH	632.0
DYNC1I2	583.0
LEMD2	434.0
CEP290	370.0
SGO2	363.0
LPIN1	305.0
TUBB6	295.0
CENPT	266.0
CENPL	253.0
KMT5A	190.0
CEP72	143.0
CEP70	10.0
PSMF1	4.0
CEP135	-44.0
H2BC1	-192.0
H2BC4	-260.0
CEP131	-335.0
H2BC5	-354.0
SEM1	-434.0
TNPO1	-470.0
PRKCA	-589.0
VRK2	-660.0
LBR	-679.0
NUP35	-710.0
RAN	-745.0
SMC4	-771.0
PSMC2	-844.0
CDC20	-1019.0
SGO1	-1205.0
CENPN	-1337.0
CLASP2	-1411.0
YWHAG	-1477.0
CENPQ	-1502.0
SEC13	-1604.0
SUMO1	-1643.0
H3C11	-1655.0
H4C12	-1743.0
H2BC12	-1772.0
CEP164	-1927.0
NUDC	-1933.0
H2BC17	-2040.0
TMPO	-2048.0
PTTG1	-2073.0
H2BC21	-2129.0
GORASP1	-2164.0
PSMD6	-2201.0
PSMD8	-2294.0
ENSA	-2320.0
TUBA4A	-2325.0
CEP78	-2378.0
TUBA4B	-2380.0
PPP2R2A	-2391.0
ESPL1	-2406.0
RPS27A	-2472.0
NEK7	-2483.0
USO1	-2498.0
ANAPC11	-2624.0
SKA1	-2643.0
PSMA2	-2726.0
CLIP1	-2732.0
H4C13	-2741.0
BLZF1	-2904.0
AHCTF1	-2954.0
NUP205	-3003.0
CENPM	-3005.0
H2BC6	-3080.0
H2BC15	-3142.0
PSMB4	-3191.0
YWHAE	-3214.0
H2AC20	-3235.0
NCAPH2	-3256.0
HSP90AA1	-3286.0
H3-4	-3300.0
PPP1CC	-3357.0
H2AZ2	-3381.0
PSMA8	-3478.0
CDK5RAP2	-3491.0
NUP50	-3509.0
CENPS	-3513.0
SKA2	-3548.0
NDE1	-3667.0
NUP210	-3669.0
NEK9	-3707.0
TUBGCP5	-3712.0
H2BC9	-3718.5
H3C7	-3718.5
LMNB1	-3736.0
CHMP3	-3897.0
POM121	-3922.0
PSMB10	-3966.0
TUBA1C	-3972.0
HAUS1	-3989.0
ANAPC16	-4002.0
SET	-4012.0
ANAPC15	-4142.0
H2BC26	-4236.0
VRK1	-4259.0
PSMA5	-4274.0
TUBB	-4279.0
NME7	-4679.0
PSMB6	-4786.0
TUBGCP4	-4854.0
DYNLL1	-4954.0
SPC25	-5044.0
CENPA	-5151.0
PSMB7	-5258.0
DYNC1I1	-5309.0
HAUS3	-5315.0
DCTN2	-5318.0
UBE2C	-5371.0
CHMP2B	-5574.0
CENPH	-5646.0
NUP155	-5949.0
CHMP4A	-5994.0
PRKAR2B	-6011.0
H2AJ	-6028.0
TUBA3D	-6078.0
PPP2CB	-6157.0
PSMD2	-6176.0
H4C6	-6464.0
SPC24	-6708.0
UBC	-6842.0
H4C2	-6995.0
TUBB4A	-7113.0
CENPE	-7223.0
RAB2A	-7245.0
NEK2	-7458.0
UBE2E1	-7595.0
TUBA3C	-7603.0
PSME1	-7763.0
CEP63	-7908.0
H3C4	-8000.0
TUBB2A	-8021.0
POM121C	-8073.0
H2AC4	-8140.0
H3C10	-8206.0
PSMB11	-8541.0
H2AC7	-8707.5
H2BC7	-8707.5
TUBA3E	-8723.0
SPDL1	-8769.0
CSNK1E	-8775.0
TUBAL3	-9053.0
H3C12	-9106.0
H2BC13	-9329.0
CHMP4C	-9374.0
KIF2B	-9529.0

---

REACTOME_CELL_CYCLE_CHECKPOINTS

REACTOME_CELL_CYCLE_CHECKPOINTS

	1120
set	REACTOME_CELL_CYCLE_CHECKPOINTS
setSize	284
pANOVA	3.59e-06
s.dist	0.16
p.adjustANOVA	0.000327

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
PSMD3	11142
NUP37	10891
NSL1	10890
PPP2R5D	10754
H2BC3	10676
RCC2	10660
PIAS4	10486
PSMC1	10399
CCNB2	10190
PSMB1	10173
UBA52	10169
B9D2	10123
NUP85	10105
ATR	10067
PSMC6	9892
ZW10	9885
ORC1	9866

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DYNLL2	11280.0
MAPRE1	11267.0
DYNC1LI2	11173.0
PSMD3	11142.0
NUP37	10891.0
NSL1	10890.0
PPP2R5D	10754.0
H2BC3	10676.0
RCC2	10660.0
PIAS4	10486.0
PSMC1	10399.0
CCNB2	10190.0
PSMB1	10173.0
UBA52	10169.0
B9D2	10123.0
NUP85	10105.0
ATR	10067.0
PSMC6	9892.0
ZW10	9885.0
ORC1	9866.0
CDC23	9833.0
XPO1	9708.0
ORC6	9596.0
TP53	9551.0
H2BC14	9533.0
CCNB1	9488.0
BUB1B	9436.0
RMI1	9316.0
PPP2R5A	9306.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
RPA3	9109.0
RAD9B	9100.0
H4C8	9007.0
RNF168	8997.0
SEH1L	8981.0
DNA2	8886.0
YWHAB	8801.0
PSME3	8732.0
CENPF	8713.0
BIRC5	8644.0
RAD9A	8617.0
BABAM1	8594.0
ANAPC10	8406.0
PSMD13	8389.0
KIF2A	8369.0
YWHAZ	8195.0
RPA1	8165.0
RPS27	8146.0
ZWILCH	7966.0
PSMC3	7956.0
WRN	7786.0
H4C5	7742.0
PSMA3	7703.0
DYNC1H1	7672.0
CENPC	7578.0
KNL1	7549.0
H2BC10	7509.0
RAD50	7503.0
CHEK1	7457.0
TAOK1	7414.0
PSMD7	7334.0
RANBP2	7289.0
MCM5	7141.0
PSMA7	6898.0
H4C3	6897.0
PSMA1	6861.0
TOP3A	6789.0
CDC25C	6560.0
PSMB2	6549.0
PSMC4	6484.0
ATM	6477.0
KIF2C	6395.0
UBB	6377.0
MCM7	6360.0
CDC16	6332.0
CDK1	6313.0
CENPO	6310.0
PSMD9	6250.0
KIF18A	6129.0
PPP2R5B	6021.0
CENPK	6007.0
ITGB3BP	5989.0
PSMD14	5956.0
H4C9	5774.0
PSMA6	5773.0
RANGAP1	5723.0
PKMYT1	5593.0
NUP133	5499.0
MCM8	5436.0
PSME2	5380.0
PSMD11	5320.0
UBE2S	5276.0
CHEK2	5205.0
PHF20	5189.0
CDC26	5157.0
RFC2	5115.0
ANAPC1	5092.0
CDKN1B	5083.0
H2BC8	5070.0
PSMB5	5052.0
NSD2	4961.0
COP1	4959.0
PSMB3	4835.0
PPP2R1B	4800.0
CENPP	4572.0
RPA2	4484.0
AURKB	4455.0
DYNC1LI1	4367.0
NUF2	4365.0
NUP107	4332.0
ORC4	4299.0
NDEL1	4296.0
PMF1	4252.0
PSME4	4171.0
MAD1L1	4118.0
PPP2R5C	4099.0
MDM2	4051.0
H2BC11	4044.0
CLSPN	4002.0
PSMD12	3928.0
TOPBP1	3907.0
CCNE2	3867.0
CDKN2A	3849.0
RAD17	3845.0
ANAPC7	3809.0
CENPU	3739.0
PSMD5	3711.0
PSMB8	3681.0
PSMA4	3640.0
ORC2	3590.0
NBN	3589.0
RFC4	3563.0
MDC1	3549.0
MIS12	3486.0
PCBP4	3406.0
UIMC1	3376.0
ANAPC5	3355.0
ANAPC4	3312.0
INCENP	3298.0
MAD2L1	3280.0
BUB3	3260.0
MCM3	3239.0
H2AX	3086.0
PSMD1	3063.0
ORC5	2938.0
NUP43	2770.0
CKAP5	2726.0
CDC27	2701.0
WEE1	2466.0
CLASP1	2462.0
NUP98	2445.0
RFC3	2420.0
PPP2R5E	2327.0
PSMB9	2322.0
H4C1	2273.0
NUP160	2051.0
ZWINT	2046.0
ANAPC2	1989.0
NDC80	1973.0
DBF4	1954.0
CCNA2	1874.0
KNTC1	1764.0
PLK1	1754.0
RMI2	1748.0
MDM4	1716.0
GTSE1	1709.0
YWHAH	1632.0
CDCA8	1598.0
DSN1	1571.0
PSMC5	1519.0
CDC6	1513.0
BRCA1	1471.0
H4C4	1434.0
BUB1	1430.0
UBE2D1	1355.0
PPP2CA	1345.0
CDC45	1297.0
ZNF385A	1287.0
PAFAH1B1	1262.0
RBBP8	1178.0
YWHAQ	1114.0
PPP2R1A	849.0
ORC3	791.0
DYNC1I2	583.0
CDC7	394.0
SGO2	363.0
MCM2	327.0
CENPT	266.0
CENPL	253.0
BABAM2	234.0
CDC25A	220.0
PSMF1	4.0
H2BC1	-192.0
H2BC4	-260.0
EXO1	-290.0
H2BC5	-354.0
MRE11	-382.0
RAD1	-410.0
SEM1	-434.0
PSMC2	-844.0
CDC20	-1019.0
SGO1	-1205.0
HUS1	-1275.0
CENPN	-1337.0
CLASP2	-1411.0
YWHAG	-1477.0
CENPQ	-1502.0
ABRAXAS1	-1564.0
SEC13	-1604.0
H4C12	-1743.0
MCM4	-1749.0
H2BC12	-1772.0
NUDC	-1933.0
BLM	-1963.0
H2BC17	-2040.0
H2BC21	-2129.0
MCM10	-2132.0
BARD1	-2156.0
PSMD6	-2201.0
CDKN1A	-2242.0
PSMD8	-2294.0
RPS27A	-2472.0
ANAPC11	-2624.0
SKA1	-2643.0
RHNO1	-2686.0
PSMA2	-2726.0
CLIP1	-2732.0
H4C13	-2741.0
AHCTF1	-2954.0
CENPM	-3005.0
TP53BP1	-3024.0
H2BC6	-3080.0
H2BC15	-3142.0
PSMB4	-3191.0
YWHAE	-3214.0
H3-4	-3300.0
PPP1CC	-3357.0
PSMA8	-3478.0
CENPS	-3513.0
SKA2	-3548.0
NDE1	-3667.0
H2BC9	-3718.5
UBE2V2	-3757.0
PSMB10	-3966.0
ANAPC16	-4002.0
CCNE1	-4003.0
RNF8	-4058.0
RFC5	-4136.0
ANAPC15	-4142.0
H2BC26	-4236.0
MCM6	-4245.0
BRIP1	-4248.0
PSMA5	-4274.0
HERC2	-4445.0
CCNA1	-4580.0
KAT5	-4633.0
SFN	-4660.0
PSMB6	-4786.0
ATRIP	-4882.0
DYNLL1	-4954.0
SPC25	-5044.0
CENPA	-5151.0
PSMB7	-5258.0
DYNC1I1	-5309.0
UBE2C	-5371.0
CENPH	-5646.0
PPP2CB	-6157.0
PSMD2	-6176.0
H4C6	-6464.0
CDK2	-6684.0
SPC24	-6708.0
UBE2N	-6780.0
UBC	-6842.0
H4C2	-6995.0
CENPE	-7223.0
UBE2E1	-7595.0
PSME1	-7763.0
PSMB11	-8541.0
H2BC7	-8707.5
SPDL1	-8769.0
H2BC13	-9329.0
KIF2B	-9529.0

---

REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

	1024
set	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION
setSize	1356
pANOVA	9.35e-06
s.dist	0.0717
p.adjustANOVA	0.000808

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LYPD8	11804
P4HB	11751
B3GNT7	11748
SATB1	11652
PREB	11612
HRC	11539
TAB1	11522
SKIC8	11483
MUC5AC	11476
SPRN	11458
VGF	11410
TUBB8	11383
ASB10	11362
RAB5C	11356
LYPD3	11345
AMDHD2	11315
TUBB1	11311
RAB25	11281
DYNLL2	11280
CHML	11271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LYPD8	11804.0
P4HB	11751.0
B3GNT7	11748.0
SATB1	11652.0
PREB	11612.0
HRC	11539.0
TAB1	11522.0
SKIC8	11483.0
MUC5AC	11476.0
SPRN	11458.0
VGF	11410.0
TUBB8	11383.0
ASB10	11362.0
RAB5C	11356.0
LYPD3	11345.0
AMDHD2	11315.0
TUBB1	11311.0
RAB25	11281.0
DYNLL2	11280.0
CHML	11271.0
DDB2	11268.0
H2AC14	11207.0
DYNC1LI2	11173.0
PSMD3	11142.0
TRIM28	11100.0
NSMCE3	11058.0
RNF181	11051.0
MAN2A2	11043.0
ST6GALNAC4	11041.0
SYVN1	11015.0
PMM1	11013.0
RNF40	11002.0
MAN1C1	10949.0
MSLN	10936.0
FBXL22	10901.0
NUP37	10891.0
TTL	10884.0
A4GNT	10882.0
NAPA	10847.0
SCG3	10824.0
PPP6C	10759.0
HLTF	10690.0
H2BC3	10676.0
LY6G6D	10667.0
DAXX	10654.0
ACTR10	10640.0
TMEM129	10616.0
CD52	10606.0
UBA2	10516.0
TADA2B	10501.0
PIAS4	10486.0
USP2	10472.0
EEF2KMT	10462.0
USP44	10450.0
ASB16	10434.0
FCSK	10402.0
PSMC1	10399.0
USP33	10378.0
BCL10	10375.0
UBE2I	10324.0
MRTFA	10318.0
DPH2	10312.0
HNRNPK	10300.0
TFPT	10255.0
GCNT7	10252.0
USP8	10243.0
F10	10236.0
PCNA	10230.0
KCTD6	10198.0
UBE2M	10180.0
PSMB1	10173.0
BTRC	10171.0
UBA52	10169.0
ADRB2	10166.0
PRKCSH	10158.0
FBXL14	10148.0
TTLL13	10137.0
USP22	10127.0
ARF5	10109.0
NUP85	10105.0
ATXN3	10084.0
TMED9	10059.0
DHPS	10033.0
CHGB	9965.0
UBE2K	9963.0
NAPG	9921.0
RAB22A	9908.0
PSMC6	9892.0
SMURF2	9848.0
COMMD7	9807.0
COG8	9798.0
KBTBD6	9793.0
UBE2G2	9792.0
DCAF16	9780.0
DCAF10	9756.0
KDELR1	9735.0
SMAD2	9684.0
BET1L	9669.0
ABRAXAS2	9667.0
KLHL21	9661.0
FKBP8	9642.0
COG1	9635.0
ADRM1	9610.0
RFT1	9601.0
UBE2W	9585.0
TGFBR1	9558.0
TP53	9551.0
DDA1	9548.0
H2BC14	9533.0
COPA	9517.0
PPP6R1	9503.0
YKT6	9491.0
DDX5	9484.0
UBA3	9455.0
TPGS1	9452.0
RAB1A	9448.0
LHB	9421.0
RAB7A	9383.0
FN3KRP	9351.0
RAB8A	9327.0
FBXL3	9325.0
RAB21	9307.0
SHPRH	9288.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
MUC20	9203.0
FBXL15	9202.0
ENAM	9183.0
SIN3A	9180.0
POFUT2	9161.0
FAM20A	9104.0
NPLOC4	9066.0
ST6GALNAC1	9064.0
BST1	9061.0
SPSB3	9039.0
ST6GAL1	9031.0
VDAC2	9021.0
H4C8	9007.0
RNF168	8997.0
SEH1L	8981.0
SAE1	8966.0
FSTL3	8965.0
HIC1	8956.0
UBE2L3	8944.0
RIGI	8912.0
DPH1	8864.0
PAF1	8840.0
ACTB	8836.0
ANO8	8798.0
RAB40C	8783.0
FBXO44	8757.0
SEC22C	8748.0
VCPIP1	8740.0
PSME3	8732.0
RAB11B	8725.0
NRN1	8714.0
SPTB	8693.0
BIRC5	8644.0
DDOST	8630.0
RELA	8623.0
BABAM1	8594.0
NUS1	8556.0
AHSG	8511.0
CREBBP	8505.0
PTP4A2	8468.0
SELENOS	8464.0
H2AC16	8457.0
RNF7	8452.0
TUBA1B	8427.0
SUMO2	8422.0
CHD3	8412.0
H2AC8	8407.0
PSMD13	8389.0
ADAMTSL4	8348.0
TTLL10	8320.0
FBXL16	8317.0
SCG2	8310.0
NUP88	8287.0
KCTD7	8268.0
RRAGA	8261.0
NUP42	8255.0
CUL4A	8254.0
ARF4	8225.0
RPA1	8165.0
UBXN7	8130.0
TOMM20	8125.0
RBBP5	8079.0
DERL1	8060.0
POLB	8057.0
FGA	8035.0
MBD6	8003.0
RNF123	7984.0
RAB39A	7981.0
FEM1A	7975.0
UGGT1	7973.0
CCNF	7968.0
PSMC3	7956.0
KBTBD7	7923.0
GALNT8	7910.0
VASH2	7904.0
UFD1	7888.0
VHL	7882.0
FUOM	7826.0
UBE2Q2	7817.0
TDG	7808.0
FBXO30	7801.0
SAR1B	7795.0
WRN	7786.0
NUP62	7784.0
TTLL12	7777.0
MUCL1	7768.0
MUC6	7745.0
H4C5	7742.0
RAB5B	7736.0
TRAPPC5	7735.0
POMK	7731.0
RAB17	7730.0
TADA3	7721.0
RAB8B	7720.0
ALG11	7706.0
PSMA3	7703.0
HDAC1	7688.0
ARSJ	7675.0
DYNC1H1	7672.0
GAN	7657.0
IDE	7653.0
UBE2T	7607.0
ASB7	7598.0
COPE	7577.0
B3GALNT2	7556.0
DPH3	7555.0
FBXO21	7551.0
FEM1C	7539.0
MUC3A	7534.0
DPH7	7520.0
H2BC10	7509.0
PMM2	7507.0
GALNT6	7493.0
KDELR3	7486.0
ASXL1	7481.0
DAD1	7467.0
CCP110	7454.0
TPR	7435.0
TMED3	7427.0
ST8SIA3	7420.0
MVD	7397.0
DCAF13	7394.0
ARCN1	7391.0
ZNF131	7363.0
TFAP2A	7347.0
PSMD7	7334.0
LRR1	7332.0
QSOX1	7314.0
RAB3B	7309.0
ZRANB1	7307.0
RANBP2	7289.0
LGALS1	7279.0
EEF2	7278.0
EDEM3	7263.0
H2AC17	7258.0
WAC	7253.0
ARF3	7245.0
PARP1	7236.0
TOP2B	7207.0
FBXW7	7200.0
MAVS	7199.0
FOLR2	7198.0
PENK	7179.0
IFIH1	7159.0
SUMO3	7150.0
COPG1	7147.0
LY6E	7144.0
ST3GAL2	7128.0
RNF2	7121.0
USP7	7118.0
LEO1	7116.0
ST3GAL1	7090.0
WDR20	7074.0
NUCB1	7055.0
NSF	7053.0
ARSK	7009.0
NUP93	6988.0
MBD1	6986.0
NEDD8	6981.0
FBXO6	6972.0
COPS4	6956.0
SENP1	6955.0
TPST1	6944.0
ACTL6A	6941.0
ACTR8	6934.0
PSMA7	6898.0
H4C3	6897.0
ALG1	6872.0
KDELR2	6871.0
B3GNT6	6865.0
PSMA1	6861.0
OTUB1	6847.0
DCAF6	6845.0
EEF1AKMT2	6842.0
GALNT12	6836.0
ETFB	6834.0
FBXO7	6820.0
ADAMTS5	6796.0
LMAN2	6788.0
PIAS2	6771.0
USP12	6750.0
INO80E	6749.0
COG5	6736.0
ALG5	6724.0
NUP214	6722.0
FOXK2	6705.0
PPARA	6700.0
GCNT1	6694.0
KLHL11	6653.0
RNF144A	6618.0
B3GLCT	6586.0
PSMB2	6549.0
GALNT11	6498.0
PML	6494.0
PSMC4	6484.0
PEX12	6471.0
LMAN1	6470.0
NR5A2	6463.0
LYPD6B	6462.0
MBTPS1	6456.0
HDAC2	6444.0
COL7A1	6429.0
BIRC2	6410.0
COMMD5	6408.0
FBXO15	6407.0
FBXO41	6404.0
EDEM1	6403.0
RAE1	6386.0
UBB	6377.0
SPTA1	6372.0
ASB6	6351.0
FBXW2	6343.0
IL33	6335.0
CDK1	6313.0
APLP2	6312.0
EEF1A1	6294.0
NR1I2	6283.0
NUP153	6267.0
PSMD9	6250.0
COMMD8	6238.0
TUBB4B	6227.0
DCTN1	6189.0
CBX8	6182.0
STT3A	6155.0
DPH6	6147.0
SKP2	6108.0
B4GALT3	6107.0
LY6D	6099.0
EIF5A	6093.0
NUP188	6088.0
LYPD4	6076.0
SAFB	6049.0
PALB2	6043.0
TUBB2B	6024.0
COMMD10	6013.0
USP15	6004.0
RNF185	5994.0
ALG3	5987.0
WDR5	5961.0
PSMD14	5956.0
SEC16A	5944.0
MYC	5940.0
ASB8	5939.0
SMAD7	5937.0
ST8SIA5	5899.0
MELTF	5874.0
H2AC11	5849.0
PRMT3	5841.0
NUP54	5830.0
ASXL2	5808.0
VDAC3	5792.0
RBX1	5779.0
H4C9	5774.0
PSMA6	5773.0
ADAM10	5772.0
NR1H2	5767.0
DCTN5	5764.0
DCUN1D2	5753.0
ALG10B	5744.0
RIPK2	5736.0
SOCS5	5731.0
CUL7	5727.0
FBXW4	5726.0
KLHL22	5724.0
RANGAP1	5723.0
GFUS	5706.0
KTN1	5705.0
BET1	5686.0
EP300	5668.0
C3	5665.0
RTN4RL1	5662.0
SEC23A	5642.0
FEM1B	5603.0
ALPL	5582.0
DCUN1D5	5578.0
ULBP2	5575.0
F5	5573.0
HIF1A	5570.0
CCDC8	5568.0
TRAPPC9	5522.0
NUP133	5499.0
TRAPPC6A	5486.0
SEC24A	5482.0
TUBA1A	5468.0
VCP	5453.0
ALG2	5447.0
PIGP	5428.0
PIGB	5426.0
DOHH	5406.0
SERPIND1	5400.0
PSME2	5380.0
FOXL2	5363.0
PSMD11	5320.0
SMAD4	5313.0
UBE2S	5276.0
MCRS1	5265.0
TOP1	5250.0
PIGQ	5247.0
TPGS2	5242.0
GALNT3	5226.0
CBX4	5225.0
CSNK1D	5214.0
NRN1L	5213.0
ASGR2	5204.0
COPB2	5181.0
FBXL4	5136.0
H2AC18	5121.5
H2AC19	5121.5
DNAJC24	5112.0
CALU	5095.0
H2BC8	5070.0
PSMB5	5052.0
FBXO2	5041.0
CALM1	5021.0
ELOB	5019.0
RAB24	5005.0
RAB18	4983.0
PIGX	4977.0
PEX14	4973.0
COP1	4959.0
VNN1	4943.0
ARFGAP2	4921.0
H2AC15	4918.0
MGAT1	4900.0
DCUN1D3	4896.0
MUC12	4894.0
NUP58	4880.0
CTSC	4842.0
RAB11A	4839.0
PSMB3	4835.0
SCMH1	4833.0
GBF1	4829.0
SERPINA10	4817.0
VDAC1	4793.0
PEX10	4750.0
AAAS	4718.0
SOCS6	4701.0
USP47	4689.0
UHRF2	4669.0
FBXO32	4667.0
KLHL9	4642.0
FBXW5	4627.0
USP42	4623.0
ADAMTSL5	4584.0
PGM3	4560.0
VDR	4546.0
MTA1	4534.0
MAT2B	4530.0
KAT2A	4523.0
RECK	4507.0
NR5A1	4492.0
OTUD7B	4486.0
TMEM132A	4457.0
AURKB	4455.0
NFRKB	4427.0
COPS6	4422.0
MITF	4419.0
PEX2	4402.0
SPSB1	4397.0
PUM2	4392.0
MGAT5	4389.0
USP14	4377.0
DYNC1LI1	4367.0
TFAP2B	4362.0
DCTN3	4358.0
MUC21	4357.0
STC2	4354.0
SEC31A	4349.0
NUP107	4332.0
ITIH2	4320.0
NEGR1	4305.0
ARSG	4298.0
INO80D	4272.0
PIGT	4264.0
NDC1	4258.0
OTULIN	4254.0
SERPINC1	4218.0
PGR	4206.0
TRAF3	4183.0
PRKDC	4181.0
PSME4	4171.0
COPB1	4158.0
USP24	4149.0
COMMD2	4123.0
ING2	4091.0
ALG8	4072.0
MDM2	4051.0
H2BC11	4044.0
UBE2D3	4033.0
RABGGTB	4023.0
NFKB2	4022.0
CLSPN	4002.0
PIGW	3939.0
ELOC	3936.0
PSMD12	3928.0
ETFBKMT	3923.0
UBE2B	3873.0
GMPPB	3870.0
CDKN2A	3849.0
ARRB2	3835.0
SMC5	3826.0
CSF1	3813.0
UCHL5	3789.0
TUBB3	3788.0
GALNT14	3786.0
TOMM70	3776.0
TGFBR2	3758.0
HIPK2	3717.0
PSMD5	3711.0
PSMB8	3681.0
RTF1	3666.0
PSMA4	3640.0
GCNT4	3632.0
INS	3627.0
RARA	3613.0
COPS2	3612.0
HDAC4	3576.0
TRAPPC10	3575.0
AGBL5	3555.0
MDC1	3549.0
NSMCE2	3533.0
STAMBPL1	3531.0
EEF1AKMT1	3528.0
NSMCE4A	3515.0
LARGE2	3472.0
RAB4A	3465.0
RAB20	3451.0
PCSK9	3448.0
RAB33B	3439.0
UBA6	3394.0
RCN1	3385.0
UIMC1	3376.0
HGS	3373.0
WSB1	3370.0
FBXL20	3335.0
RAB29	3334.0
EDEM2	3303.0
INCENP	3298.0
DNAJC3	3289.0
PIAS1	3286.0
CNIH3	3278.0
RNF152	3207.0
B3GNT5	3196.0
NANP	3186.0
GANAB	3184.0
RAB36	3183.0
TRAF2	3169.0
STAG1	3161.0
RIPK1	3149.0
PIGL	3145.0
CDC73	3140.0
SEC24C	3133.0
USP16	3126.0
TOP2A	3104.0
FUT8	3099.0
PLAUR	3093.0
HSP90B1	3092.0
ARRB1	3085.0
L3MBTL2	3084.0
GOSR2	3081.0
RAB31	3078.0
GOSR1	3074.0
RAD52	3071.0
PSMD1	3063.0
COMMD6	3028.0
ICMT	3009.0
TRIM25	3005.0
USP20	2996.0
PIGN	2971.0
AURKA	2948.0
DPM1	2943.0
JOSD1	2934.0
SOCS2	2900.0
B4GALT4	2896.0
MUC4	2880.0
RAD21	2837.0
NSMCE1	2817.0
RWDD3	2812.0
B3GNTL1	2810.0
UBE2D2	2801.0
FBN1	2787.0
TNKS	2784.0
NUP43	2770.0
RAB23	2763.0
RCE1	2749.0
POMT1	2739.0
RAB1B	2714.0
TRAPPC6B	2693.0
FBXW8	2672.0
DERL2	2662.0
SATB2	2643.0
AXIN2	2631.0
GALNT2	2620.0
FUCA1	2600.0
IGFBP5	2564.0
ADAMTS4	2533.0
CTR9	2523.0
SMC3	2481.0
NR3C1	2470.0
PIGZ	2465.0
NUP98	2445.0
NR2C1	2430.0
PIGF	2429.0
PEX5	2404.0
GOLGA2	2395.0
COG3	2373.0
JOSD2	2354.0
RAET1L	2347.0
TTLL5	2340.0
SBSPON	2331.0
PSMB9	2322.0
SPTBN2	2275.0
H4C1	2273.0
KLHL3	2247.0
DNMT3A	2244.0
APC	2233.0
RHOA	2230.0
COPG2	2223.0
APOE	2205.0
ASB14	2176.0
SPSB2	2174.0
WDTC1	2168.0
SPTBN1	2163.0
HSPA8	2120.0
ARFGAP3	2119.0
HIF3A	2118.0
B4GAT1	2117.0
RAB12	2086.0
COPZ2	2075.0
RPS2	2069.0
NUP160	2051.0
DOLPP1	2012.0
KIN	1970.0
FBXL8	1967.0
GGCX	1966.0
LMAN2L	1944.0
TBC1D20	1930.0
CDC34	1908.0
CCNA2	1874.0
SPTBN4	1858.0
MAN1B1	1853.0
CHST8	1847.0
CNIH2	1845.0
UGGT2	1838.0
USP25	1833.0
CTSA	1820.0
RAB10	1814.0
PIGC	1808.0
ST3GAL3	1802.0
NR4A2	1800.0
COPS3	1756.0
RAB3A	1751.0
FBXO9	1741.0
B3GNT3	1739.0
SP3	1720.0
RAB14	1719.0
MDM4	1716.0
KNG1	1700.0
FBXL13	1679.0
UBE2F	1669.0
CD55	1667.0
DCAF7	1646.0
RAB19	1633.0
CDCA8	1598.0
PTEN	1587.0
LAMB2	1584.0
PSMC5	1519.0
H2AC6	1509.0
GALNT7	1507.0
TUBA8	1505.0
KLHL41	1501.0
PIGU	1500.0
GMPPA	1498.0
BMI1	1490.0
TEX101	1486.0
FOXK1	1482.0
FPGT	1475.0
APP	1473.0
BRCA1	1471.0
SKP1	1470.0
RNF103	1467.0
H4C4	1434.0
SVBP	1431.0
AGBL3	1418.0
GPIHBP1	1414.0
NAE1	1413.0
UBE2D1	1355.0
AFP	1347.0
ACTR1A	1341.0
MXRA8	1333.0
GALNT16	1300.0
NANS	1277.0
USP30	1266.0
RHOT1	1244.0
TRRAP	1239.0
SEL1L	1220.0
DCUN1D4	1214.0
GLB1	1210.0
ARFGAP1	1182.0
TRIM13	1179.0
ADAMTS8	1145.0
TTLL9	1131.0
RAET1G	1111.0
ASB3	1069.0
NOP58	1062.0
UBXN1	1026.0
MGAT2	1019.5
MGAT3	988.0
APOA1	983.0
ALB	974.0
SENP2	956.0
SUMF1	945.0
RPN1	944.0
AXIN1	936.0
VCPKMT	932.0
GALNT15	926.0
ATXN7	886.0
FBXO31	872.0
DCTN6	866.0
FBXL18	842.0
KLHL2	812.0
UBE2R2	801.0
MAN1A1	795.0
ST6GALNAC2	766.0
GALNT10	754.0
COMMD3	741.0
NEU2	713.0
TGFB1	696.0
BTBD6	681.0
DDX17	675.0
KDM1B	672.0
SPTAN1	668.0
SPSB4	645.0
FBXL5	635.0
DHDDS	630.0
INO80	601.0
RNF146	589.0
PIGH	588.0
DYNC1I2	583.0
PROZ	573.0
NEU1	542.0
FAM20C	538.0
SUMF2	531.0
GALNT4	522.0
ALG14	473.0
ANK1	472.0
CMAS	454.0
RAD23B	413.0
USP3	399.0
TNIP1	354.0
SUZ12	349.0
MUL1	313.0
LYPD2	296.0
TUBB6	295.0
EID3	269.0
SDC2	259.0
DAG1	257.0
BABAM2	234.0
TOPORS	232.0
CDC25A	220.0
KLHL20	219.0
XRCC4	193.0
RAB5A	180.0
WSB2	165.0
CANX	160.0
MCFD2	137.0
ST3GAL5	122.0
ZNF350	88.0
USP37	85.0
FBXW12	74.0
PEX13	54.0
FBXL19	44.0
ALG9	39.0
NCOA1	37.0
MLEC	34.0
SENP8	8.0
PSMF1	4.0
GMDS	-13.0
CD109	-27.0
TAF10	-28.0
MAN1A2	-34.0
OBSL1	-39.0
MUC16	-87.0
YOD1	-90.0
USP49	-114.0
OS9	-137.0
GOLM1	-142.0
TTLL11	-168.0
TRAPPC4	-184.0
H2BC1	-192.0
H2BC4	-260.0
ADAMTS12	-262.0
RNF139	-277.0
USP5	-289.0
PTRH2	-293.0
RAB26	-298.0
TPST2	-302.0
AMFR	-321.0
THRA	-326.0
BAP1	-345.0
H2BC5	-354.0
SIAH2	-371.0
BTBD1	-380.0
NEURL2	-392.0
CUL3	-394.0
FBXO40	-404.0
FGF23	-421.0
B4GALNT2	-429.0
SEM1	-434.0
EIF5A2	-451.0
ARSI	-457.0
MGAT4A	-459.0
LRRC41	-487.0
PIGK	-502.0
CAMKMT	-503.0
DPAGT1	-518.0
MEN1	-532.0
AGTPBP1	-544.0
PIAS3	-565.0
DTL	-613.0
PIGM	-615.0
SP100	-617.0
CCN1	-618.0
TRAF6	-626.0
RAB3C	-640.0
ALPG	-674.0
GPS1	-685.0
CST3	-688.0
ART4	-699.0
NUP35	-710.0
IGFBP3	-725.0
ASB13	-732.0
MPI	-734.0
PROS1	-772.0
DDB1	-806.0
B3GNT4	-815.0
ADAMTS20	-825.0
EPAS1	-831.0
CPM	-842.0
PSMC2	-844.0
KEAP1	-855.0
STAM2	-857.0
NFKBIA	-865.0
FUT3	-879.0
AMTN	-881.0
FBXO22	-886.0
FGG	-894.0
HLA-A	-902.0
STX17	-947.0
SMC6	-948.0
SNX3	-957.0
UBE2E3	-961.0
RAB40B	-1002.0
CDC20	-1019.0
RAB43	-1025.0
YY1	-1037.0
UBE2G1	-1045.0
LRRC49	-1054.0
C1GALT1	-1058.0
GOLGB1	-1078.0
COG7	-1080.0
SCFD1	-1086.0
LAMB1	-1090.0
THBS2	-1099.0
MARCHF6	-1100.0
TNKS2	-1105.0
FBXL12	-1121.0
H2AC21	-1139.0
PIGG	-1144.0
SPTBN5	-1170.0
TTLL7	-1193.0
PIGV	-1241.0
USP19	-1244.0
NTNG1	-1253.0
ADAMTS13	-1264.0
TGOLN2	-1267.0
NFE2L2	-1323.0
SUDS3	-1326.0
B4GALT6	-1327.0
RAB30	-1357.0
ASB1	-1365.0
RTN4RL2	-1369.0
ADAMTS6	-1374.0
GALNT9	-1386.0
ADAMTS3	-1387.0
NTNG2	-1420.0
ALG10	-1423.0
RAB2B	-1467.0
VASH1	-1472.0
USP28	-1488.0
TTLL1	-1492.0
MAP3K7	-1507.0
UAP1	-1511.0
PRSS21	-1521.0
RAB4B	-1524.0
DCAF17	-1537.0
ABRAXAS1	-1564.0
SEMA5B	-1582.0
SEC13	-1604.0
WDR48	-1608.0
SHISA5	-1617.0
PPP6R3	-1620.0
SUMO1	-1643.0
CGA	-1710.0
DOLK	-1714.0
SERPINA1	-1732.0
H4C12	-1743.0
STAMBP	-1764.0
H2BC12	-1772.0
RAB27B	-1780.0
GALNTL6	-1790.0
NUDT14	-1826.0
ARSA	-1842.0
TULP4	-1850.0
DPP3	-1853.0
PLET1	-1866.0
SEC22A	-1898.0
ART3	-1940.0
TNFAIP3	-1941.0
BLM	-1963.0
SQSTM1	-1966.0
XPC	-1967.0
ARF1	-1980.0
RAB44	-1984.0
SEC22B	-2002.0
H2BC17	-2040.0
AGBL2	-2046.0
USP13	-2080.0
THSD4	-2087.0
PGAP1	-2092.0
H2BC21	-2129.0
RPN2	-2137.0
BARD1	-2156.0
GORASP1	-2164.0
BMP4	-2196.0
PSMD6	-2201.0
TMED7	-2215.0
AMBN	-2228.0
NCOA2	-2231.0
HNRNPC	-2240.0
CDKN1A	-2242.0
FBXW11	-2247.0
UBE2J2	-2266.0
PSMD8	-2294.0
PARK7	-2305.0
TUBA4A	-2325.0
MFGE8	-2364.0
SRD5A3	-2374.0
METTL21A	-2376.0
TUBA4B	-2380.0
USP34	-2403.0
CKAP4	-2418.0
MAN2A1	-2420.0
USP48	-2423.0
ST8SIA4	-2436.0
SEC23IP	-2437.0
LSAMP	-2469.0
RPS27A	-2472.0
PHC3	-2479.0
RAB27A	-2485.0
USO1	-2498.0
CUL2	-2524.0
MIA2	-2536.0
NGLY1	-2549.0
DCAF8	-2582.0
H2AC1	-2599.0
FBXO11	-2639.0
MANEA	-2655.0
TRAPPC1	-2657.0
POMT2	-2695.0
ST3GAL4	-2716.0
CEACAM5	-2718.0
MBD5	-2723.0
USP10	-2725.0
PSMA2	-2726.0
TECTA	-2733.0
H4C13	-2741.0
ARSB	-2792.0
OTOA	-2799.0
TTLL8	-2802.0
ACTR5	-2814.0
ALG6	-2829.0
SENP5	-2850.0
OTUB2	-2869.0
FBXO17	-2873.0
TFG	-2891.0
NLRP3	-2898.0
B3GNT9	-2901.0
FBXW9	-2921.0
SSPOP	-2924.0
GFPT1	-2928.0
FN1	-2929.0
TFAP2C	-2934.0
KLHL25	-2989.0
KBTBD8	-2991.0
COPS8	-2997.0
NUP205	-3003.0
CNIH1	-3022.0
TP53BP1	-3024.0
RAB6A	-3077.0
H2BC6	-3080.0
NUB1	-3082.0
CAPZA2	-3094.0
PSCA	-3118.0
SEC24D	-3129.0
H2BC15	-3142.0
CAPZA1	-3166.0
RNF5	-3178.0
BECN1	-3180.0
PSMB4	-3191.0
PDIA6	-3199.0
ASGR1	-3202.0
H2AC20	-3235.0
MATN3	-3239.0
PROC	-3241.0
PIGS	-3268.0
RING1	-3272.0
OTUD3	-3284.0
ASB4	-3303.0
ST6GALNAC3	-3321.0
PRSS23	-3334.0
SPON2	-3361.0
CFTR	-3432.0
NR1H3	-3438.0
ADAMTS7	-3441.0
SPACA4	-3472.0
PSMA8	-3478.0
NUP50	-3509.0
NOTUM	-3519.0
GNE	-3527.0
F7	-3552.0
INO80B	-3583.0
VNN2	-3596.0
MGAT4C	-3605.0
PIGO	-3643.0
KAT2B	-3652.0
TTLL3	-3668.0
NUP210	-3669.0
IL6	-3702.0
H2BC9	-3718.5
UBE2V2	-3757.0
RNF20	-3774.0
TNIP3	-3786.0
ESR1	-3799.0
RAB35	-3803.0
LMO7	-3805.0
CAPZB	-3829.0
PPARG	-3832.0
SLC17A5	-3839.0
SEC24B	-3858.0
INO80C	-3882.0
TRAPPC2L	-3889.0
COG6	-3915.0
LY6H	-3916.0
CYLD	-3921.0
POM121	-3922.0
TRIM27	-3949.0
IGFBP4	-3950.0
COPZ1	-3956.0
PSMB10	-3966.0
TUBA1C	-3972.0
NEU3	-4020.0
LAMC1	-4032.0
POMGNT1	-4034.0
MUC5B	-4060.0
SEC16B	-4129.0
PPARGC1A	-4177.0
H2BC26	-4236.0
DCAF11	-4256.0
NR3C2	-4264.0
PSMA5	-4274.0
USP4	-4331.0
NAPB	-4352.0
H2AC25	-4404.0
HERC2	-4445.0
PHC2	-4460.0
DCAF5	-4471.0
UBE2Z	-4475.0
GALNT5	-4490.0
GALNTL5	-4525.0
GALNT18	-4548.0
ALG12	-4550.0
RAB37	-4554.0
CCNA1	-4580.0
ANK3	-4596.0
ADAMTSL3	-4604.0
ERCC8	-4624.0
CTBP1	-4646.0
GPAA1	-4647.0
SPON1	-4670.0
PIGY	-4672.0
SPP1	-4765.0
COPS5	-4770.0
PSMB6	-4786.0
MUC7	-4805.0
CUL5	-4806.0
ADAMTS18	-4814.0
CHST10	-4817.0
STX5	-4820.0
COPS7B	-4924.0
UBE2H	-4933.0
TRAPPC3	-4941.0
DYNLL1	-4954.0
CNTN5	-4956.0
LYPD5	-5012.0
COG4	-5014.0
VCAN	-5103.0
RAB15	-5108.0
ZBTB16	-5134.0
TMEM115	-5148.0
MIA3	-5155.0
UCHL1	-5167.0
UCHL3	-5172.0
FBXO27	-5179.0
ASB17	-5180.0
USP21	-5187.0
COMMD1	-5190.0
NCOR2	-5218.0
IGFBP7	-5236.0
CNTN4	-5242.0
PSMB7	-5258.0
DYNC1I1	-5309.0
ADAMTS10	-5316.0
DCTN2	-5318.0
UBE2C	-5371.0
DMP1	-5373.0
STAM	-5412.0
GALNT13	-5423.0
FBXO4	-5429.0
MYSM1	-5431.0
CALR	-5434.0
CAND1	-5476.0
DNMT3B	-5480.0
RAD23A	-5485.0
MPDU1	-5514.0
MUC17	-5527.0
IGFBP1	-5545.0
POMGNT2	-5632.0
DPM3	-5653.0
TF	-5680.0
KLHL5	-5697.0
ADAMTSL2	-5731.0
ALPI	-5732.0
PCGF2	-5737.0
MGAT4B	-5741.0
CBX5	-5750.0
ST8SIA2	-5755.0
HDAC7	-5767.0
ADAMTS17	-5768.0
RAB38	-5785.0
PRND	-5805.0
GRIA1	-5814.0
LTBP1	-5819.0
ANK2	-5829.0
GCNT3	-5832.0
TMED2	-5837.0
ANKRD28	-5843.0
PDIA3	-5865.0
COG2	-5873.0
TRIM4	-5899.0
MDGA2	-5900.0
THSD7A	-5903.0
COMMD9	-5911.0
ST8SIA6	-5944.0
NUP155	-5949.0
NAGK	-5982.0
CHST4	-6059.0
RAB3D	-6066.0
TUBA3D	-6078.0
DCAF4	-6104.0
NR1H4	-6111.0
TNC	-6113.0
WFS1	-6121.0
SEMA5A	-6127.0
RXRA	-6154.0
ST6GALNAC6	-6158.0
PSMD2	-6176.0
GFPT2	-6186.0
GALNT1	-6215.0
ADAMTS15	-6221.0
DPM2	-6230.0
CEACAM7	-6239.0
APOB	-6247.0
OTUD7A	-6254.0
CD59	-6280.0
RAB32	-6289.0
ADAMTS19	-6311.0
ADAMTS1	-6344.0
USP18	-6354.0
NEU4	-6366.0
CUL1	-6388.0
RUVBL1	-6422.0
DCTN4	-6447.0
THSD7B	-6455.0
H4C6	-6464.0
FUCA2	-6474.0
LYPD1	-6489.0
CUL9	-6504.0
UBD	-6591.0
ST8SIA1	-6605.0
B4GALT2	-6642.0
CISH	-6648.0
DCUN1D1	-6665.0
NTM	-6666.0
ST6GALNAC5	-6694.0
MEPE	-6697.0
ST3GAL6	-6707.0
ADAMTS14	-6721.0
MUC13	-6740.0
B4GALT1	-6744.0
RAB6B	-6747.0
SLC35A1	-6755.0
DPH5	-6757.0
UBE2N	-6780.0
THSD1	-6782.0
B3GNT8	-6788.0
SMAD1	-6789.0
GNPNAT1	-6807.0
UBC	-6842.0
GPLD1	-6905.0
BPIFB2	-6907.0
PRKN	-6909.0
FBXW10	-6910.0
ST6GAL2	-6911.0
FBXL7	-6924.0
NPM1	-6941.0
ASB15	-6959.0
ASB18	-6966.0
SPARCL1	-6968.0
TGFA	-6980.0
H4C2	-6995.0
ENGASE	-7004.0
MDGA1	-7025.0
RORA	-7027.0
PRSS41	-7053.0
LY6G6C	-7082.0
CP	-7100.0
APOA2	-7112.0
TUBB4A	-7113.0
TNIP2	-7133.0
B4GALT5	-7138.0
LY6K	-7143.0
ADAMTS2	-7149.0
FOLR1	-7168.0
FN3K	-7177.0
COPS7A	-7190.0
RAD18	-7192.0
AGBL1	-7206.0
RAB2A	-7245.0
B3GNT2	-7261.0
RABGGTA	-7330.0
RAB13	-7343.0
ASB5	-7360.0
MUC1	-7378.0
THBS1	-7436.0
IKBKE	-7451.0
DNMT1	-7491.0
CTSZ	-7493.0
CBX2	-7506.0
AREG	-7512.0
NOD1	-7516.0
AGBL4	-7558.0
ANKRD9	-7585.0
UBE2E1	-7595.0
TTLL6	-7597.0
TUBA3C	-7603.0
KLHL42	-7605.0
RNF135	-7633.0
F2	-7650.0
CDH2	-7653.0
ADAMTS9	-7672.0
FSTL1	-7687.0
APOL1	-7742.0
GATA3	-7751.0
PSME1	-7763.0
OPCML	-7787.0
TUBB2A	-8021.0
POM121C	-8073.0
ADAMTSL1	-8077.0
TMED10	-8116.0
MUC15	-8136.0
H2AC4	-8140.0
VWA1	-8166.0
THRB	-8179.0
TUSC3	-8180.0
TECTB	-8193.0
LARGE1	-8263.0
NPL	-8323.0
APOA5	-8348.0
SLC35C1	-8351.0
UMOD	-8417.0
TTLL4	-8420.0
LMAN1L	-8471.0
CNTN3	-8475.0
GALNT17	-8482.0
MOGS	-8526.0
PSMB11	-8541.0
SMAD3	-8542.0
IZUMO1R	-8551.0
H2AC12	-8592.0
METTL22	-8645.0
NRIP1	-8667.0
BIRC3	-8670.0
H2AC7	-8707.5
H2BC7	-8707.5
TUBA3E	-8723.0
COMMD4	-8830.0
SOCS3	-8908.0
FURIN	-8937.0
ADAMTS16	-8974.0
CAPZA3	-8975.0
PHC1	-9004.0
THY1	-9007.0
EVA1A	-9018.0
TUBAL3	-9053.0
ASB2	-9069.0
H2AC13	-9179.0
GP2	-9286.0
H2BC13	-9329.0
FBXO10	-9381.0
SPP2	-9390.0
PNPLA2	-9426.0
TTLL2	-9530.0
NOD2	-9647.0
NICN1	-9660.0
RAB42	-9779.0
C4A	-9849.5
RAB34	-10008.0
BGLAP	-10040.0
FCGR3B	-10179.0

---

REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

	1636
set	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION
setSize	361
pANOVA	1.75e-05
s.dist	0.132
p.adjustANOVA	0.00143

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIM69	11636
RNF114	11462
ASB10	11362
TRIM41	11303
S100A1	11297
STX4	11170
PSMD3	11142
MYLIP	11009
FBXL22	10901
CTSS	10734
HLA-F	10704
ASB16	10434
PSMC1	10399
RNF34	10341
TRIM37	10316
RNF14	10277
KCTD6	10198
IKBKB	10186
UBE2M	10180
PSMB1	10173

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIM69	11636
RNF114	11462
ASB10	11362
TRIM41	11303
S100A1	11297
STX4	11170
PSMD3	11142
MYLIP	11009
FBXL22	10901
CTSS	10734
HLA-F	10704
ASB16	10434
PSMC1	10399
RNF34	10341
TRIM37	10316
RNF14	10277
KCTD6	10198
IKBKB	10186
UBE2M	10180
PSMB1	10173
BTRC	10171
UBA52	10169
FBXL14	10148
UBA5	10140
HECTD1	10078
UBE2K	9963
PSMC6	9892
PJA2	9890
SMURF2	9848
CDC23	9833
KBTBD6	9793
UBE2G2	9792
RNF138	9666
KLHL21	9661
UBE2W	9585
DTX3L	9562
UBA3	9455
FBXL3	9325
PSMD4	9234
HLA-E	9228
FBXL15	9202
TAPBP	9184
HERC4	9143
HMGB1	9074
TLR4	8957
UBE2L3	8944
FBXO44	8757
PSME3	8732
SEC61G	8671
SOCS1	8601
ATG14	8600
B2M	8560
RNF7	8452
ANAPC10	8406
PSMD13	8389
PIK3R4	8377
FBXL16	8317
KCTD7	8268
GLMN	8081
FGA	8035
RNF41	8004
RNF123	7984
CCNF	7968
PSMC3	7956
ERAP2	7941
KBTBD7	7923
VHL	7882
UBE2Q2	7817
FBXO30	7801
SAR1B	7795
HECTD3	7769
PSMA3	7703
MKRN1	7684
UBOX5	7677
GAN	7657
ASB7	7598
FBXO21	7551
BLMH	7385
PSMD7	7334
LRR1	7332
FBXW7	7200
TRIM63	7155
RNF126	7064
FBXO6	6972
PSMA7	6898
PSMA1	6861
FBXO7	6820
RBBP6	6670
KLHL11	6653
PSMB2	6549
PSMC4	6484
UBE2Q1	6472
MYD88	6416
FBXO15	6407
MEX3C	6406
FBXO41	6404
UBB	6377
ASB6	6351
FBXW2	6343
CDC16	6332
PSMD9	6250
LY96	6229
SKP2	6108
VAMP8	6082
SEC61A1	6064
ITCH	6063
HLA-B	6020
UBE2V1	6001
PSMD14	5956
ASB8	5939
RNF19B	5919
UBE2O	5875
RBX1	5779
PSMA6	5773
CUL7	5727
FBXW4	5726
KLHL22	5724
SEC23A	5642
UBE4A	5618
UBE3A	5579
SEC24A	5482
NCF2	5455
TRIM50	5450
PSME2	5380
PSMD11	5320
UBE2S	5276
CDC26	5157
FBXL4	5136
ANAPC1	5092
PSMB5	5052
FBXO2	5041
ELOB	5019
TRIM36	4996
MGRN1	4994
LTN1	4906
HERC1	4846
PSMB3	4835
RCHY1	4826
RNF19A	4782
UBR2	4779
TPP2	4712
FBXO32	4667
CYBA	4649
KLHL9	4642
FBXW5	4627
NPEPPS	4564
SEC61B	4500
UNKL	4478
RNF4	4464
SPSB1	4397
SEC31A	4349
RBCK1	4346
PSME4	4171
CHUK	4148
LONRF1	4057
UBE2D3	4033
ELOC	3936
PSMD12	3928
UBE2B	3873
ANAPC7	3809
UFL1	3753
PSMD5	3711
PSMB8	3681
PSMA4	3640
DZIP3	3495
HERC5	3473
RNF115	3445
UBA6	3394
TRIM9	3392
FGB	3371
WSB1	3370
ANAPC5	3355
FBXL20	3335
FZR1	3328
ANAPC4	3312
SNAP23	3273
UBAC1	3221
SEC24C	3133
PSMD1	3063
TAP1	3001
UBE2D2	2801
TRAF7	2766
CDC27	2701
FBXW8	2672
THOP1	2590
TRIM11	2436
PSMB9	2322
UBR1	2321
UBR4	2290
PIK3C3	2277
KLHL3	2247
ASB14	2176
SPSB2	2174
DCAF1	2142
ANAPC2	1989
FBXL8	1967
TRIM39	1960
CDC34	1908
ITGAV	1791
FBXO9	1741
UBE2D4	1732
FBXL13	1679
UBE2F	1669
VAMP3	1589
RNF25	1588
WWP1	1551
TRIP12	1530
PSMC5	1519
KLHL41	1501
SKP1	1470
UBE2D1	1355
RNF213	1338
HERC6	1320
CD36	1267
AREL1	1242
HLA-C	1212
MIB2	1138
ASB3	1069
SIAH1	935
FBXO31	872
FBXL18	842
KLHL2	812
UBE2R2	801
BTBD6	681
SPSB4	645
FBXL5	635
ARIH2	594
UBE3B	237
KLHL20	219
CANX	160
SH3RF1	147
FBXW12	74
FBXL19	44
CBLB	40
PSMF1	4
TAP2	-129
TRAIP	-216
SIAH2	-371
BTBD1	-380
RNF130	-383
CUL3	-394
FBXO40	-404
SEM1	-434
LRRC41	-487
HLA-G	-673
ASB13	-732
PSMC2	-844
KEAP1	-855
FBXO22	-886
FGG	-894
HLA-A	-902
UBE2E3	-961
CDC20	-1019
MRC2	-1027
UBE2G1	-1045
ERAP1	-1076
FBXL12	-1121
RNF6	-1165
UBE2U	-1201
RNF111	-1255
TLR2	-1307
ASB1	-1365
CD14	-1377
SEC13	-1604
UBE3C	-1645
LRSAM1	-1811
TLR1	-1972
SEC22B	-2002
ZNRF2	-2034
SMURF1	-2045
CTSV	-2071
PSMD6	-2201
HERC3	-2238
FBXW11	-2247
UBE2J2	-2266
PSMD8	-2294
RPS27A	-2472
CUL2	-2524
ITGB5	-2538
HACE1	-2566
ANAPC11	-2624
FBXO11	-2639
PSMA2	-2726
TRIM71	-2816
FBXO17	-2873
RNF182	-2877
UBE2E2	-2908
FBXW9	-2921
KLHL25	-2989
KBTBD8	-2991
SEC24D	-3129
BECN1	-3180
PSMB4	-3191
ASB4	-3303
STUB1	-3378
PSMA8	-3478
NCF4	-3559
HECTD2	-3565
UBE2V2	-3757
LMO7	-3805
SEC24B	-3858
PSMB10	-3966
TIRAP	-4162
PSMA5	-4274
CTSL	-4367
LNX1	-4398
HERC2	-4445
UBE2Z	-4475
SEC61A2	-4521
UBA7	-4653
HSPA5	-4707
PSMB6	-4786
CUL5	-4806
UBE2H	-4933
RNF220	-5019
NEDD4	-5049
ZBTB16	-5134
FBXO27	-5179
ASB17	-5180
PSMB7	-5258
UBE2C	-5371
RNF217	-5389
FBXO4	-5429
CALR	-5434
KLHL5	-5697
PDIA3	-5865
TRIM4	-5899
UBE2L6	-6074
PSMD2	-6176
CUL1	-6388
UBE2J1	-6610
HECW2	-6728
UBE2N	-6780
LNPEP	-6802
UBC	-6842
DET1	-6890
PRKN	-6909
FBXW10	-6910
FBXL7	-6924
ASB15	-6959
ASB18	-6966
UBE3D	-7074
ASB5	-7360
ATG7	-7371
UBE2E1	-7595
KLHL42	-7605
PSME1	-7763
ANAPC13	-7845
TRIM32	-8141
NEDD4L	-8238
RNF144B	-8520
PSMB11	-8541
SOCS3	-8908
ASB2	-9069
S100A9	-9088
TLR6	-9151
CD207	-9200
TRIM21	-9251
S100A8	-9296
FBXO10	-9381
ZNRF1	-9889

---

REACTOME_HIV_INFECTION

REACTOME_HIV_INFECTION

	175
set	REACTOME_HIV_INFECTION
setSize	223
pANOVA	1.9e-05
s.dist	0.166
p.adjustANOVA	0.00148

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	11679
CD8B	11589
CD247	11377
PSMD3	11142
NUP37	10891
TCEA1	10805
VPS28	10677
PSMC1	10399
NELFB	10298
GTF2F1	10225
PSMB1	10173
BTRC	10171
POLR2E	10170
UBA52	10169
NUP85	10105
AP1M2	10055
TAF15	10036
GTF2H5	10024
TAF12	10008
AP1B1	9985

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	11679
CD8B	11589
CD247	11377
PSMD3	11142
NUP37	10891
TCEA1	10805
VPS28	10677
PSMC1	10399
NELFB	10298
GTF2F1	10225
PSMB1	10173
BTRC	10171
POLR2E	10170
UBA52	10169
NUP85	10105
AP1M2	10055
TAF15	10036
GTF2H5	10024
TAF12	10008
AP1B1	9985
PSMC6	9892
CXCR4	9856
XPO1	9708
SUPT5H	9702
NCBP2	9630
AP2A2	9440
NCBP1	9433
UBAP1	9272
PSMD4	9234
VPS4B	9032
SEH1L	8981
FEN1	8951
NELFCD	8950
KPNB1	8882
GTF2H1	8877
PSME3	8732
CTDP1	8731
POLR2D	8613
B2M	8560
GTF2H3	8555
PSMD13	8389
NUP88	8287
NUP42	8255
CHMP7	8148
LIG4	7969
PSMC3	7956
NMT2	7911
ELOA	7897
GTF2E1	7861
CHMP4B	7852
AP2A1	7850
NUP62	7784
PSMA3	7703
CD28	7686
TBP	7543
TPR	7435
PSMD7	7334
RANBP2	7289
XRCC5	7254
ATP6V1H	7249
NUP93	6988
TAF9	6942
PSMA7	6898
PSMA1	6861
RNMT	6733
NUP214	6722
VPS37D	6666
PSMB2	6549
BANF1	6504
PSMC4	6484
RAE1	6386
UBB	6377
PDCD6IP	6334
NUP153	6267
PSMD9	6250
PACS1	6174
NUP188	6088
PSMD14	5956
NUP54	5830
RBX1	5779
PSMA6	5773
RANGAP1	5723
PAK2	5671
CHMP2A	5566
CCNT1	5525
NUP133	5499
NELFE	5395
PSME2	5380
PSMD11	5320
CHMP5	5312
POLR2I	5240
SUPT4H1	5215
PSMB5	5052
POLR2A	5042
ELOB	5019
VPS37A	4916
NUP58	4880
PSMB3	4835
SUPT16H	4733
AAAS	4718
DOCK2	4518
NELFA	4446
AP1G1	4423
NUP107	4332
NDC1	4258
PSME4	4171
POLR2F	4146
AP2S1	4029
ELOC	3936
PSMD12	3928
XRCC6	3920
TAF2	3833
POLR2H	3756
PSMD5	3711
PSMB8	3681
PSMA4	3640
CHMP6	3463
RCC1	3413
CDK7	3307
GTF2A1	3275
AP1M1	3128
PSMD1	3063
NUP43	2770
APOBEC3G	2696
AP1S1	2669
PPIA	2546
KPNA1	2495
NUP98	2445
SSRP1	2333
PSMB9	2322
VPS4A	2225
NUP160	2051
TSG101	1714
RANBP1	1690
PSMC5	1519
SKP1	1470
LIG1	1254
GTF2E2	1248
MNAT1	1066
GTF2H4	1040
POLR2B	1016
TAF3	788
AP2B1	724
TAF13	443
XRCC4	193
PSMF1	4
TAF10	-28
VPS37B	-333
POLR2G	-351
SEM1	-434
TAF4	-484
NUP35	-710
RAN	-745
ELL	-755
POLR2K	-795
PSMC2	-844
HLA-A	-902
SLC25A4	-1021
TAF5	-1088
AP1S3	-1188
CCNK	-1375
HMGA1	-1414
CCNT2	-1429
POLR2C	-1547
SEC13	-1604
GTF2A2	-1840
ARF1	-1980
TAF4B	-2117
PSMD6	-2201
PSMD8	-2294
RPS27A	-2472
MVB12B	-2505
PSIP1	-2714
PSMA2	-2726
RAC1	-2752
NUP205	-3003
GTF2F2	-3076
PSMB4	-3191
TAF11	-3192
AP2M1	-3365
PSMA8	-3478
NUP50	-3509
NUP210	-3669
RNGTT	-3846
CHMP3	-3897
POM121	-3922
VPS37C	-3928
PSMB10	-3966
VTA1	-4251
PSMA5	-4274
GTF2B	-4430
PSMB6	-4786
CUL5	-4806
MVB12A	-4809
ELMO1	-4914
PSMB7	-5258
ERCC3	-5361
CDK9	-5440
CHMP2B	-5574
NMT1	-5717
FYN	-5782
ERCC2	-5783
NUP155	-5949
CHMP4A	-5994
PSMD2	-6176
HCK	-6307
TAF7	-6785
UBC	-6842
NPM1	-6941
CCNH	-7541
POLR2L	-7683
PSME1	-7763
CD4	-8069
POM121C	-8073
TAF1L	-8088
CCR5	-8092
NEDD4L	-8238
PSMB11	-8541
FURIN	-8937
TAF6	-9176
CHMP4C	-9374
POLR2J	-9382
ELOA2	-9527

---

REACTOME_TCR_SIGNALING

REACTOME_TCR_SIGNALING

	391
set	REACTOME_TCR_SIGNALING
setSize	113
pANOVA	2.39e-05
s.dist	0.23
p.adjustANOVA	0.00178

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD3D	11806
CD3G	11740
LCK	11679
GRAP2	11494
CD3E	11468
CD247	11377
HLA-DQA1	11196
PSMD3	11142
VASP	10862
CSK	10710
PSMC1	10399
BCL10	10375
IKBKB	10186
PSMB1	10173
BTRC	10171
UBA52	10169
LAT	10161
PDPK1	10091
PTPN22	9969
PSMC6	9892

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD3D	11806
CD3G	11740
LCK	11679
GRAP2	11494
CD3E	11468
CD247	11377
HLA-DQA1	11196
PSMD3	11142
VASP	10862
CSK	10710
PSMC1	10399
BCL10	10375
IKBKB	10186
PSMB1	10173
BTRC	10171
UBA52	10169
LAT	10161
PDPK1	10091
PTPN22	9969
PSMC6	9892
LCP2	9437
PSMD4	9234
PSME3	8732
RELA	8623
PSMD13	8389
PSMC3	7956
PSMA3	7703
PSMD7	7334
PSMA7	6898
PSMA1	6861
NFKB1	6611
PSMB2	6549
PSMC4	6484
UBB	6377
PSMD9	6250
HLA-DPA1	6073
UBE2V1	6001
PSMD14	5956
PTPRC	5790
PSMA6	5773
RIPK2	5736
PTPRJ	5677
PAK2	5671
ENAH	5407
PSME2	5380
PSMD11	5320
ZAP70	5143
HLA-DRB1	5087
PSMB5	5052
INPP5D	4892
PSMB3	4835
PAK1	4761
HLA-DRA	4610
PLCG1	4604
MALT1	4261
PIK3CA	4175
PSME4	4171
CHUK	4148
EVL	4121
PSMD12	3928
PSMD5	3711
PSMB8	3681
PSMA4	3640
PSMD1	3063
UBE2D2	2801
FYB1	2718
HLA-DRB5	2685
PRKCQ	2519
PSMB9	2322
ITK	2180
CDC34	1908
PTEN	1587
PSMC5	1519
SKP1	1470
UBE2D1	1355
TAB2	1079
CD101	780
HLA-DPB1	768
PIK3R2	686
TRAT1	420
PSMF1	4
PAG1	-266
CARD11	-272
SEM1	-434
TRAF6	-626
PSMC2	-844
NFKBIA	-865
HLA-DQB1	-1110
MAP3K7	-1507
PSMD6	-2201
FBXW11	-2247
PSMD8	-2294
RPS27A	-2472
PSMA2	-2726
PIK3R1	-2742
NCK1	-2888
PSMB4	-3191
PIK3CB	-3212
PSMA8	-3478
PSMB10	-3966
PSMA5	-4274
PSMB6	-4786
PSMB7	-5258
HLA-DQB2	-5823
HLA-DQA2	-5890
PLCG2	-6046
PSMD2	-6176
CUL1	-6388
UBE2N	-6780
UBC	-6842
PSME1	-7763
CD4	-8069
PSMB11	-8541

---

REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

	623
set	REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR
setSize	88
pANOVA	3.01e-05
s.dist	0.257
p.adjustANOVA	0.00207

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PREB	11612
SYVN1	11015
EXOSC9	10825
TATDN2	10756
CREB3L3	10553
EIF2AK3	10539
EXOSC3	10479
TLN1	10454
ZBTB17	10348
CCL2	10342
EXTL1	10082
CEBPB	9779
LMNA	9748
CXCL8	9677
MYDGF	9611
NFYB	9420
SERP1	9268
DNAJB9	9063
KHSRP	8971
SRPRB	8622

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PREB	11612
SYVN1	11015
EXOSC9	10825
TATDN2	10756
CREB3L3	10553
EIF2AK3	10539
EXOSC3	10479
TLN1	10454
ZBTB17	10348
CCL2	10342
EXTL1	10082
CEBPB	9779
LMNA	9748
CXCL8	9677
MYDGF	9611
NFYB	9420
SERP1	9268
DNAJB9	9063
KHSRP	8971
SRPRB	8622
EIF2S1	8553
DIS3	8527
ATF6	8448
EXOSC8	8126
PARN	8054
GSK3A	7873
ATP6V0D1	7494
KDELR3	7486
DNAJB11	7213
DDIT3	7173
CREB3L1	6689
EXOSC6	6642
PDIA5	6475
MBTPS1	6456
NFYA	6428
EDEM1	6403
CREB3L4	6319
EXOSC2	6293
DCTN1	6189
PPP2R5B	6021
CUL7	5727
EXOSC5	5051
FKBP14	4563
EXTL3	4472
CREB3	4432
SEC31A	4349
CEBPG	4312
SRPRA	4244
CREB3L2	3850
HDGF	3703
CTDSP2	3311
DNAJC3	3289
CREBRF	3142
HSP90B1	3092
GOSR2	3081
WIPI1	2907
CXXC1	2806
NFYC	2680
TPP1	2211
DCP2	1742
EXOSC4	1271
ARFGAP1	1182
ADD1	856
XBP1	140
EXTL2	-220
EIF2S2	-483
KLHDC3	-891
SSR1	-1346
ATF3	-1381
PLA2G4B	-2415
EXOSC7	-2604
GFPT1	-2928
PDIA6	-3199
EXOSC1	-3957
YIF1A	-4467
HSPA5	-4707
ERN1	-4747
SHC1	-4863
ASNS	-4949
HERPUD1	-4975
CALR	-5434
DDX11	-5483
ATF4	-5542
IGFBP1	-5545
WFS1	-6121
HYOU1	-7835
DCSTAMP	-7882
ACADVL	-9132

---

REACTOME_MITOTIC_PROMETAPHASE

REACTOME_MITOTIC_PROMETAPHASE

	1094
set	REACTOME_MITOTIC_PROMETAPHASE
setSize	194
pANOVA	3.02e-05
s.dist	0.174
p.adjustANOVA	0.00207

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MZT2A	11630
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
NUP37	10891
NSL1	10890
PPP2R5D	10754
RCC2	10660
HAUS6	10657
NCAPG	10503
HAUS8	10351
TUBG1	10274
CCNB2	10190
B9D2	10123
NUP85	10105
NUMA1	10088
ZW10	9885
XPO1	9708

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MZT2A	11630
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
NUP37	10891
NSL1	10890
PPP2R5D	10754
RCC2	10660
HAUS6	10657
NCAPG	10503
HAUS8	10351
TUBG1	10274
CCNB2	10190
B9D2	10123
NUP85	10105
NUMA1	10088
ZW10	9885
XPO1	9708
CCNB1	9488
BUB1B	9436
CEP192	9411
PPP2R5A	9306
CSNK2A1	9219
CEP250	9005
SEH1L	8981
CENPF	8713
BIRC5	8644
SFI1	8531
TUBA1B	8427
KIF2A	8369
TUBGCP2	8356
RPS27	8146
PCM1	7980
ZWILCH	7966
PRKACA	7965
TUBGCP6	7958
NINL	7898
CENPJ	7729
DYNC1H1	7672
CEP76	7665
AKAP9	7637
CENPC	7578
KNL1	7549
CCP110	7454
TAOK1	7414
RANBP2	7289
PDS5A	7273
CEP152	7035
EML4	6970
HAUS2	6862
KIF2C	6395
CDK1	6313
CENPO	6310
CNTRL	6286
PCNT	6271
TUBB4B	6227
DCTN1	6189
CEP57	6168
KIF18A	6129
TUBB2B	6024
PPP2R5B	6021
CENPK	6007
SMC2	6000
ITGB3BP	5989
MZT2B	5904
RANGAP1	5723
HAUS5	5711
TUBG2	5534
CDCA5	5505
NUP133	5499
TUBA1A	5468
CSNK1D	5214
TUBGCP3	5178
PLK4	5013
PPP2R1B	4800
SDCCAG8	4662
CENPP	4572
AURKB	4455
DYNC1LI1	4367
NUF2	4365
DCTN3	4358
NUP107	4332
NDEL1	4296
PMF1	4252
MAD1L1	4118
PPP2R5C	4099
CEP41	3962
TUBB3	3788
NEDD1	3782
CSNK2B	3763
CENPU	3739
MIS12	3486
INCENP	3298
MAD2L1	3280
BUB3	3260
STAG1	3161
MZT1	3049
CEP43	3035
RAD21	2837
NUP43	2770
CKAP5	2726
HAUS4	2636
SMC3	2481
CLASP1	2462
NUP98	2445
PPP2R5E	2327
ALMS1	2281
PDS5B	2276
NUP160	2051
ZWINT	2046
NDC80	1973
NCAPD2	1923
SSNA1	1783
KNTC1	1764
PLK1	1754
NEK6	1744
CDCA8	1598
DSN1	1571
TUBA8	1505
BUB1	1430
PPP2CA	1345
ACTR1A	1341
PAFAH1B1	1262
WAPL	929
ODF2	864
PPP2R1A	849
CSNK2A2	723
NCAPH	632
DYNC1I2	583
CEP290	370
SGO2	363
TUBB6	295
CENPT	266
CENPL	253
CEP72	143
CEP70	10
CEP135	-44
CEP131	-335
SMC4	-771
CDC20	-1019
SGO1	-1205
CENPN	-1337
CLASP2	-1411
YWHAG	-1477
CENPQ	-1502
SEC13	-1604
CEP164	-1927
NUDC	-1933
TUBA4A	-2325
CEP78	-2378
TUBA4B	-2380
NEK7	-2483
SKA1	-2643
CLIP1	-2732
AHCTF1	-2954
CENPM	-3005
YWHAE	-3214
HSP90AA1	-3286
PPP1CC	-3357
CDK5RAP2	-3491
CENPS	-3513
SKA2	-3548
NDE1	-3667
NEK9	-3707
TUBGCP5	-3712
TUBA1C	-3972
HAUS1	-3989
TUBB	-4279
NME7	-4679
TUBGCP4	-4854
DYNLL1	-4954
SPC25	-5044
CENPA	-5151
DYNC1I1	-5309
HAUS3	-5315
DCTN2	-5318
CENPH	-5646
PRKAR2B	-6011
TUBA3D	-6078
PPP2CB	-6157
SPC24	-6708
TUBB4A	-7113
CENPE	-7223
NEK2	-7458
TUBA3C	-7603
CEP63	-7908
TUBB2A	-8021
TUBA3E	-8723
SPDL1	-8769
CSNK1E	-8775
TUBAL3	-9053
KIF2B	-9529

---

REACTOME_SUMOYLATION

REACTOME_SUMOYLATION

	531
set	REACTOME_SUMOYLATION
setSize	179
pANOVA	3.75e-05
s.dist	0.179
p.adjustANOVA	0.00246

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SATB1	11652
TRIM28	11100
NSMCE3	11058
NUP37	10891
DAXX	10654
UBA2	10516
PIAS4	10486
UBE2I	10324
MRTFA	10318
HNRNPK	10300
PCNA	10230
NUP85	10105
TP53	9551
DDX5	9484
H4C16	9262
H4C11	9253
SIN3A	9180
H4C8	9007
RNF168	8997
SEH1L	8981

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SATB1	11652
TRIM28	11100
NSMCE3	11058
NUP37	10891
DAXX	10654
UBA2	10516
PIAS4	10486
UBE2I	10324
MRTFA	10318
HNRNPK	10300
PCNA	10230
NUP85	10105
TP53	9551
DDX5	9484
H4C16	9262
H4C11	9253
SIN3A	9180
H4C8	9007
RNF168	8997
SEH1L	8981
SAE1	8966
HIC1	8956
BIRC5	8644
RELA	8623
CREBBP	8505
SUMO2	8422
CHD3	8412
NUP88	8287
NUP42	8255
RPA1	8165
VHL	7882
TDG	7808
WRN	7786
NUP62	7784
H4C5	7742
HDAC1	7688
TPR	7435
ZNF131	7363
TFAP2A	7347
RANBP2	7289
PARP1	7236
TOP2B	7207
SUMO3	7150
RNF2	7121
NUP93	6988
MBD1	6986
SENP1	6955
H4C3	6897
PIAS2	6771
NUP214	6722
PPARA	6700
PML	6494
NR5A2	6463
HDAC2	6444
RAE1	6386
NR1I2	6283
NUP153	6267
CBX8	6182
NUP188	6088
SAFB	6049
NUP54	5830
H4C9	5774
NR1H2	5767
RANGAP1	5723
EP300	5668
NUP133	5499
FOXL2	5363
TOP1	5250
CBX4	5225
NUP58	4880
SCMH1	4833
AAAS	4718
UHRF2	4669
VDR	4546
MTA1	4534
NR5A1	4492
AURKB	4455
MITF	4419
TFAP2B	4362
NUP107	4332
NDC1	4258
PGR	4206
ING2	4091
MDM2	4051
NFKB2	4022
CDKN2A	3849
SMC5	3826
HIPK2	3717
RARA	3613
HDAC4	3576
MDC1	3549
NSMCE2	3533
NSMCE4A	3515
INCENP	3298
PIAS1	3286
STAG1	3161
TOP2A	3104
L3MBTL2	3084
RAD52	3071
AURKA	2948
RAD21	2837
NSMCE1	2817
RWDD3	2812
NUP43	2770
SATB2	2643
SMC3	2481
NR3C1	2470
NUP98	2445
NR2C1	2430
H4C1	2273
DNMT3A	2244
NUP160	2051
NR4A2	1800
SP3	1720
CDCA8	1598
BMI1	1490
BRCA1	1471
H4C4	1434
NOP58	1062
SENP2	956
DDX17	675
SUZ12	349
EID3	269
TOPORS	232
XRCC4	193
ZNF350	88
NCOA1	37
THRA	-326
PIAS3	-565
SP100	-617
NUP35	-710
NFKBIA	-865
SMC6	-948
SEC13	-1604
SUMO1	-1643
H4C12	-1743
BLM	-1963
XPC	-1967
NCOA2	-2231
HNRNPC	-2240
PARK7	-2305
PHC3	-2479
H4C13	-2741
SENP5	-2850
TFAP2C	-2934
NUP205	-3003
TP53BP1	-3024
RING1	-3272
NR1H3	-3438
NUP50	-3509
NUP210	-3669
ESR1	-3799
PPARG	-3832
POM121	-3922
TRIM27	-3949
PPARGC1A	-4177
NR3C2	-4264
HERC2	-4445
PHC2	-4460
CTBP1	-4646
NCOR2	-5218
DNMT3B	-5480
PCGF2	-5737
CBX5	-5750
HDAC7	-5767
NUP155	-5949
NR1H4	-6111
RXRA	-6154
H4C6	-6464
NPM1	-6941
H4C2	-6995
RORA	-7027
IKBKE	-7451
DNMT1	-7491
CBX2	-7506
POM121C	-8073
THRB	-8179
NRIP1	-8667
PHC1	-9004

---

REACTOME_PTEN_REGULATION

REACTOME_PTEN_REGULATION

	1079
set	REACTOME_PTEN_REGULATION
setSize	135
pANOVA	5.59e-05
s.dist	0.201
p.adjustANOVA	0.00353

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMD3	11142
HDAC5	11105
TNRC6C	10537
MTA3	10531
PSMC1	10399
SNAI2	10258
PSMB1	10173
UBA52	10169
PSMC6	9892
JUN	9721
LAMTOR4	9628
TP53	9551
NR2E1	9525
SNAI1	9520
PSMD4	9234
CSNK2A1	9219
ATN1	9128
GATAD2B	8932
PSME3	8732
HDAC3	8661

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMD3	11142
HDAC5	11105
TNRC6C	10537
MTA3	10531
PSMC1	10399
SNAI2	10258
PSMB1	10173
UBA52	10169
PSMC6	9892
JUN	9721
LAMTOR4	9628
TP53	9551
NR2E1	9525
SNAI1	9520
PSMD4	9234
CSNK2A1	9219
ATN1	9128
GATAD2B	8932
PSME3	8732
HDAC3	8661
CHD3	8412
PSMD13	8389
RRAGA	8261
CHD4	8242
REST	8214
PSMC3	7956
RRAGD	7937
PSMA3	7703
HDAC1	7688
MKRN1	7684
MAF1	7508
PSMD7	7334
RNF2	7121
USP7	7118
AGO1	6991
PSMA7	6898
PSMA1	6861
AKT1	6607
PSMB2	6549
PML	6494
PSMC4	6484
WWP2	6452
HDAC2	6444
UBB	6377
AGO2	6315
PSMD9	6250
LAMTOR5	6246
EGR1	6207
CBX8	6182
TNRC6B	6127
PSMD14	5956
AKT2	5870
PSMA6	5773
GATAD2A	5722
ATF2	5532
PSME2	5380
PSMD11	5320
CBX4	5225
EED	5078
PSMB5	5052
SALL4	5044
PSMB3	4835
SCMH1	4833
AGO3	4706
MTA1	4534
RRAGC	4408
RHEB	4311
PSME4	4171
SLC38A9	3942
PSMD12	3928
RBBP4	3906
CSNK2B	3763
PSMD5	3711
PSMB8	3681
PSMA4	3640
MBD3	3615
LAMTOR3	3112
PSMD1	3063
LAMTOR2	2942
RPTOR	2905
TNKS	2784
PSMB9	2322
MAPK3	2077
MECOM	1613
PTEN	1587
PSMC5	1519
BMI1	1490
MTOR	1229
AGO4	1166
KDM1A	1089
MAPK1	915
CSNK2A2	723
RNF146	589
SUZ12	349
PSMF1	4
EZH2	-344
SEM1	-434
PSMC2	-844
TNKS2	-1105
PREX2	-1398
AKT3	-1580
MLST8	-2078
USP13	-2080
TNRC6A	-2107
PSMD6	-2201
PSMD8	-2294
RPS27A	-2472
PHC3	-2479
PSMA2	-2726
PSMB4	-3191
RING1	-3272
OTUD3	-3284
STUB1	-3378
PSMA8	-3478
MTA2	-3732
PPARG	-3832
TRIM27	-3949
PSMB10	-3966
LAMTOR1	-4126
PSMA5	-4274
PHC2	-4460
FRK	-4708
PSMB6	-4786
MOV10	-4794
NEDD4	-5049
PSMB7	-5258
RCOR1	-5587
HDAC7	-5767
CBX6	-5952
PSMD2	-6176
UBC	-6842
CBX2	-7506
PSME1	-7763
PSMB11	-8541
PHC1	-9004

---

REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

	500
set	REACTOME_MITOTIC_METAPHASE_AND_ANAPHASE
setSize	228
pANOVA	6.39e-05
s.dist	0.154
p.adjustANOVA	0.00389

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
PSMD3	11142
NUP37	10891
NSL1	10890
PPP2R5D	10754
RCC2	10660
SIRT2	10431
ANKLE2	10427
PSMC1	10399
UBE2I	10324
CCNB2	10190
PSMB1	10173
UBA52	10169
B9D2	10123
NUP85	10105
PSMC6	9892

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
PSMD3	11142
NUP37	10891
NSL1	10890
PPP2R5D	10754
RCC2	10660
SIRT2	10431
ANKLE2	10427
PSMC1	10399
UBE2I	10324
CCNB2	10190
PSMB1	10173
UBA52	10169
B9D2	10123
NUP85	10105
PSMC6	9892
ZW10	9885
CDC23	9833
LMNA	9748
XPO1	9708
CCNB1	9488
BUB1B	9436
PPP2R5A	9306
PSMD4	9234
SEH1L	8981
KPNB1	8882
PSME3	8732
CENPF	8713
BIRC5	8644
TUBA1B	8427
ANAPC10	8406
PSMD13	8389
KIF2A	8369
CHMP7	8148
RPS27	8146
ZWILCH	7966
PSMC3	7956
CHMP4B	7852
NUP62	7784
PSMA3	7703
DYNC1H1	7672
CENPC	7578
KNL1	7549
TAOK1	7414
LEMD3	7365
PSMD7	7334
RANBP2	7289
PDS5A	7273
NUP93	6988
PSMA7	6898
PSMA1	6861
PSMB2	6549
BANF1	6504
PSMC4	6484
KIF2C	6395
UBB	6377
CDC16	6332
CDK1	6313
CENPO	6310
PSMD9	6250
TUBB4B	6227
KIF18A	6129
NUP188	6088
TUBB2B	6024
PPP2R5B	6021
CENPK	6007
ITGB3BP	5989
PSMD14	5956
NUP54	5830
PSMA6	5773
RANGAP1	5723
CHMP2A	5566
CDCA5	5505
NUP133	5499
TUBA1A	5468
PSME2	5380
PSMD11	5320
UBE2S	5276
CDC26	5157
ANAPC1	5092
PSMB5	5052
SPAST	4952
NUP58	4880
IST1	4868
PSMB3	4835
PPP2R1B	4800
CENPP	4572
AURKB	4455
DYNC1LI1	4367
NUF2	4365
NUP107	4332
NDEL1	4296
NDC1	4258
PMF1	4252
PSME4	4171
MAD1L1	4118
PPP2R5C	4099
PSMD12	3928
ANAPC7	3809
TUBB3	3788
CENPU	3739
PSMD5	3711
PSMB8	3681
PSMA4	3640
MIS12	3486
CHMP6	3463
RCC1	3413
ANAPC5	3355
ANAPC4	3312
INCENP	3298
MAD2L1	3280
BUB3	3260
STAG1	3161
PSMD1	3063
CC2D1B	2982
RAD21	2837
NUP43	2770
CKAP5	2726
CDC27	2701
SMC3	2481
CLASP1	2462
NUP98	2445
PPP2R5E	2327
PSMB9	2322
PDS5B	2276
VPS4A	2225
NUP160	2051
ZWINT	2046
ANAPC2	1989
NDC80	1973
KNTC1	1764
PLK1	1754
CDCA8	1598
DSN1	1571
PSMC5	1519
TUBA8	1505
BUB1	1430
FBXO5	1384
UBE2D1	1355
PPP2CA	1345
PAFAH1B1	1262
WAPL	929
PPP2R1A	849
DYNC1I2	583
LEMD2	434
SGO2	363
TUBB6	295
CENPT	266
CENPL	253
PSMF1	4
SEM1	-434
TNPO1	-470
VRK2	-660
LBR	-679
NUP35	-710
RAN	-745
PSMC2	-844
CDC20	-1019
SGO1	-1205
CENPN	-1337
CLASP2	-1411
CENPQ	-1502
SEC13	-1604
SUMO1	-1643
NUDC	-1933
TMPO	-2048
PTTG1	-2073
PSMD6	-2201
PSMD8	-2294
TUBA4A	-2325
TUBA4B	-2380
PPP2R2A	-2391
ESPL1	-2406
RPS27A	-2472
ANAPC11	-2624
SKA1	-2643
PSMA2	-2726
CLIP1	-2732
AHCTF1	-2954
NUP205	-3003
CENPM	-3005
PSMB4	-3191
PPP1CC	-3357
PSMA8	-3478
CENPS	-3513
SKA2	-3548
NDE1	-3667
LMNB1	-3736
CHMP3	-3897
POM121	-3922
PSMB10	-3966
TUBA1C	-3972
ANAPC16	-4002
ANAPC15	-4142
VRK1	-4259
PSMA5	-4274
PSMB6	-4786
DYNLL1	-4954
SPC25	-5044
CENPA	-5151
PSMB7	-5258
DYNC1I1	-5309
UBE2C	-5371
CHMP2B	-5574
CENPH	-5646
NUP155	-5949
CHMP4A	-5994
TUBA3D	-6078
PPP2CB	-6157
PSMD2	-6176
SPC24	-6708
UBC	-6842
TUBB4A	-7113
CENPE	-7223
UBE2E1	-7595
TUBA3C	-7603
PSME1	-7763
TUBB2A	-8021
PSMB11	-8541
TUBA3E	-8723
SPDL1	-8769
TUBAL3	-9053
CHMP4C	-9374
KIF2B	-9529

---

REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS

REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS

	176
set	REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS
setSize	127
pANOVA	7.45e-05
s.dist	0.204
p.adjustANOVA	0.00436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	11679
CD8B	11589
CD247	11377
PSMD3	11142
NUP37	10891
PSMC1	10399
PSMB1	10173
BTRC	10171
UBA52	10169
NUP85	10105
AP1M2	10055
AP1B1	9985
PSMC6	9892
XPO1	9708
AP2A2	9440
PSMD4	9234
SEH1L	8981
KPNB1	8882
PSME3	8732
B2M	8560

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	11679
CD8B	11589
CD247	11377
PSMD3	11142
NUP37	10891
PSMC1	10399
PSMB1	10173
BTRC	10171
UBA52	10169
NUP85	10105
AP1M2	10055
AP1B1	9985
PSMC6	9892
XPO1	9708
AP2A2	9440
PSMD4	9234
SEH1L	8981
KPNB1	8882
PSME3	8732
B2M	8560
PSMD13	8389
NUP88	8287
NUP42	8255
PSMC3	7956
AP2A1	7850
NUP62	7784
PSMA3	7703
CD28	7686
TPR	7435
PSMD7	7334
RANBP2	7289
ATP6V1H	7249
NUP93	6988
PSMA7	6898
PSMA1	6861
NUP214	6722
PSMB2	6549
BANF1	6504
PSMC4	6484
RAE1	6386
UBB	6377
NUP153	6267
PSMD9	6250
PACS1	6174
NUP188	6088
PSMD14	5956
NUP54	5830
RBX1	5779
PSMA6	5773
RANGAP1	5723
PAK2	5671
CCNT1	5525
NUP133	5499
PSME2	5380
PSMD11	5320
PSMB5	5052
ELOB	5019
NUP58	4880
PSMB3	4835
AAAS	4718
DOCK2	4518
AP1G1	4423
NUP107	4332
NDC1	4258
PSME4	4171
AP2S1	4029
ELOC	3936
PSMD12	3928
PSMD5	3711
PSMB8	3681
PSMA4	3640
RCC1	3413
AP1M1	3128
PSMD1	3063
NUP43	2770
APOBEC3G	2696
AP1S1	2669
PPIA	2546
KPNA1	2495
NUP98	2445
PSMB9	2322
NUP160	2051
RANBP1	1690
PSMC5	1519
SKP1	1470
AP2B1	724
PSMF1	4
SEM1	-434
NUP35	-710
RAN	-745
PSMC2	-844
HLA-A	-902
SLC25A4	-1021
AP1S3	-1188
HMGA1	-1414
SEC13	-1604
ARF1	-1980
PSMD6	-2201
PSMD8	-2294
RPS27A	-2472
PSIP1	-2714
PSMA2	-2726
RAC1	-2752
NUP205	-3003
PSMB4	-3191
AP2M1	-3365
PSMA8	-3478
NUP50	-3509
NUP210	-3669
POM121	-3922
PSMB10	-3966
PSMA5	-4274
PSMB6	-4786
CUL5	-4806
ELMO1	-4914
PSMB7	-5258
CDK9	-5440
FYN	-5782
NUP155	-5949
PSMD2	-6176
HCK	-6307
UBC	-6842
NPM1	-6941
PSME1	-7763
CD4	-8069
POM121C	-8073
PSMB11	-8541

---

REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

	1635
set	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION
setSize	296
pANOVA	7.7e-05
s.dist	0.134
p.adjustANOVA	0.00436

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRIM69	11636
RNF114	11462
ASB10	11362
TRIM41	11303
PSMD3	11142
MYLIP	11009
FBXL22	10901
ASB16	10434
PSMC1	10399
RNF34	10341
TRIM37	10316
RNF14	10277
KCTD6	10198
UBE2M	10180
PSMB1	10173
BTRC	10171
UBA52	10169
FBXL14	10148
UBA5	10140
HECTD1	10078

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRIM69	11636
RNF114	11462
ASB10	11362
TRIM41	11303
PSMD3	11142
MYLIP	11009
FBXL22	10901
ASB16	10434
PSMC1	10399
RNF34	10341
TRIM37	10316
RNF14	10277
KCTD6	10198
UBE2M	10180
PSMB1	10173
BTRC	10171
UBA52	10169
FBXL14	10148
UBA5	10140
HECTD1	10078
UBE2K	9963
PSMC6	9892
PJA2	9890
SMURF2	9848
CDC23	9833
KBTBD6	9793
UBE2G2	9792
RNF138	9666
KLHL21	9661
UBE2W	9585
DTX3L	9562
UBA3	9455
FBXL3	9325
PSMD4	9234
FBXL15	9202
HERC4	9143
UBE2L3	8944
FBXO44	8757
PSME3	8732
SOCS1	8601
RNF7	8452
ANAPC10	8406
PSMD13	8389
FBXL16	8317
KCTD7	8268
GLMN	8081
RNF41	8004
RNF123	7984
CCNF	7968
PSMC3	7956
KBTBD7	7923
VHL	7882
UBE2Q2	7817
FBXO30	7801
HECTD3	7769
PSMA3	7703
MKRN1	7684
UBOX5	7677
GAN	7657
ASB7	7598
FBXO21	7551
BLMH	7385
PSMD7	7334
LRR1	7332
FBXW7	7200
TRIM63	7155
RNF126	7064
FBXO6	6972
PSMA7	6898
PSMA1	6861
FBXO7	6820
RBBP6	6670
KLHL11	6653
PSMB2	6549
PSMC4	6484
UBE2Q1	6472
FBXO15	6407
MEX3C	6406
FBXO41	6404
UBB	6377
ASB6	6351
FBXW2	6343
CDC16	6332
PSMD9	6250
SKP2	6108
ITCH	6063
UBE2V1	6001
PSMD14	5956
ASB8	5939
RNF19B	5919
UBE2O	5875
RBX1	5779
PSMA6	5773
CUL7	5727
FBXW4	5726
KLHL22	5724
UBE4A	5618
UBE3A	5579
TRIM50	5450
PSME2	5380
PSMD11	5320
UBE2S	5276
CDC26	5157
FBXL4	5136
ANAPC1	5092
PSMB5	5052
FBXO2	5041
ELOB	5019
TRIM36	4996
MGRN1	4994
LTN1	4906
HERC1	4846
PSMB3	4835
RCHY1	4826
RNF19A	4782
UBR2	4779
TPP2	4712
FBXO32	4667
KLHL9	4642
FBXW5	4627
NPEPPS	4564
UNKL	4478
RNF4	4464
SPSB1	4397
RBCK1	4346
PSME4	4171
LONRF1	4057
UBE2D3	4033
ELOC	3936
PSMD12	3928
UBE2B	3873
ANAPC7	3809
UFL1	3753
PSMD5	3711
PSMB8	3681
PSMA4	3640
DZIP3	3495
HERC5	3473
RNF115	3445
UBA6	3394
TRIM9	3392
WSB1	3370
ANAPC5	3355
FBXL20	3335
FZR1	3328
ANAPC4	3312
UBAC1	3221
PSMD1	3063
UBE2D2	2801
TRAF7	2766
CDC27	2701
FBXW8	2672
THOP1	2590
TRIM11	2436
PSMB9	2322
UBR1	2321
UBR4	2290
KLHL3	2247
ASB14	2176
SPSB2	2174
DCAF1	2142
ANAPC2	1989
FBXL8	1967
TRIM39	1960
CDC34	1908
FBXO9	1741
UBE2D4	1732
FBXL13	1679
UBE2F	1669
RNF25	1588
WWP1	1551
TRIP12	1530
PSMC5	1519
KLHL41	1501
SKP1	1470
UBE2D1	1355
RNF213	1338
HERC6	1320
AREL1	1242
MIB2	1138
ASB3	1069
SIAH1	935
FBXO31	872
FBXL18	842
KLHL2	812
UBE2R2	801
BTBD6	681
SPSB4	645
FBXL5	635
ARIH2	594
UBE3B	237
KLHL20	219
SH3RF1	147
FBXW12	74
FBXL19	44
CBLB	40
PSMF1	4
TRAIP	-216
SIAH2	-371
BTBD1	-380
RNF130	-383
CUL3	-394
FBXO40	-404
SEM1	-434
LRRC41	-487
ASB13	-732
PSMC2	-844
KEAP1	-855
FBXO22	-886
UBE2E3	-961
CDC20	-1019
UBE2G1	-1045
FBXL12	-1121
RNF6	-1165
UBE2U	-1201
RNF111	-1255
ASB1	-1365
UBE3C	-1645
LRSAM1	-1811
ZNRF2	-2034
SMURF1	-2045
PSMD6	-2201
HERC3	-2238
FBXW11	-2247
UBE2J2	-2266
PSMD8	-2294
RPS27A	-2472
CUL2	-2524
HACE1	-2566
ANAPC11	-2624
FBXO11	-2639
PSMA2	-2726
TRIM71	-2816
FBXO17	-2873
RNF182	-2877
UBE2E2	-2908
FBXW9	-2921
KLHL25	-2989
KBTBD8	-2991
PSMB4	-3191
ASB4	-3303
STUB1	-3378
PSMA8	-3478
HECTD2	-3565
UBE2V2	-3757
LMO7	-3805
PSMB10	-3966
PSMA5	-4274
LNX1	-4398
HERC2	-4445
UBE2Z	-4475
UBA7	-4653
PSMB6	-4786
CUL5	-4806
UBE2H	-4933
RNF220	-5019
NEDD4	-5049
ZBTB16	-5134
FBXO27	-5179
ASB17	-5180
PSMB7	-5258
UBE2C	-5371
RNF217	-5389
FBXO4	-5429
KLHL5	-5697
TRIM4	-5899
UBE2L6	-6074
PSMD2	-6176
CUL1	-6388
UBE2J1	-6610
HECW2	-6728
UBE2N	-6780
LNPEP	-6802
UBC	-6842
DET1	-6890
PRKN	-6909
FBXW10	-6910
FBXL7	-6924
ASB15	-6959
ASB18	-6966
UBE3D	-7074
ASB5	-7360
ATG7	-7371
UBE2E1	-7595
KLHL42	-7605
PSME1	-7763
ANAPC13	-7845
TRIM32	-8141
NEDD4L	-8238
RNF144B	-8520
PSMB11	-8541
SOCS3	-8908
ASB2	-9069
TRIM21	-9251
FBXO10	-9381
ZNRF1	-9889

---

REACTOME_SARS_COV_INFECTIONS

REACTOME_SARS_COV_INFECTIONS

	1541
set	REACTOME_SARS_COV_INFECTIONS
setSize	392
pANOVA	9.22e-05
s.dist	0.115
p.adjustANOVA	0.00504

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAB1	11522
PDCD1	11469
CRB3	11436
PARP10	11422
TLR9	11359
IFNA1	11270
CD79A	11237
IFNGR1	11180
VAV1	11098
ST6GALNAC4	11041
ISG15	10963
VPS33B	10926
NUP37	10891
IRF7	10885
HLA-F	10704
RPS24	10632
RCAN3	10631
IFNA13	10532
MTA3	10531
ZDHHC8	10428

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAB1	11522.0
PDCD1	11469.0
CRB3	11436.0
PARP10	11422.0
TLR9	11359.0
IFNA1	11270.0
CD79A	11237.0
IFNGR1	11180.0
VAV1	11098.0
ST6GALNAC4	11041.0
ISG15	10963.0
VPS33B	10926.0
NUP37	10891.0
IRF7	10885.0
HLA-F	10704.0
RPS24	10632.0
RCAN3	10631.0
IFNA13	10532.0
MTA3	10531.0
ZDHHC8	10428.0
UBE2I	10324.0
SNRPD2	10271.0
TUFM	10261.0
IKBKB	10186.0
UBA52	10169.0
SNRPF	10159.0
PRKCSH	10158.0
VPS39	10128.0
NUP85	10105.0
PDPK1	10091.0
ZBP1	10043.0
DDX20	9996.0
ANO10	9945.0
PSMC6	9892.0
S1PR1	9720.0
FXYD6	9670.0
BRMS1	9660.0
DDX5	9484.0
AP2A2	9440.0
ISCU	9371.0
ATP1B2	9300.0
HLA-E	9228.0
STAT2	9208.0
GEMIN4	9188.0
IFNA16	9121.0
ST6GAL1	9031.0
IFNA8	8989.0
SEH1L	8981.0
GATAD2B	8932.0
RIGI	8912.0
KPNB1	8882.0
SIGMAR1	8829.0
YWHAB	8801.0
ANO8	8798.0
DDOST	8630.0
RELA	8623.0
ATG14	8600.0
B2M	8560.0
CREBBP	8505.0
CHD3	8412.0
IFNAR1	8400.0
PIK3R4	8377.0
RPS14	8357.0
GPC2	8334.0
NUP88	8287.0
RPS20	8266.0
NUP42	8255.0
CHD4	8242.0
PPIG	8231.0
SRPK1	8218.0
REST	8214.0
YWHAZ	8195.0
CHMP7	8148.0
RPS27	8146.0
IMPDH2	8108.0
FAU	8073.0
RPS5	8053.0
SMN1	8042.5
SMN2	8042.5
PARP9	7970.0
VHL	7882.0
GSK3A	7873.0
CHMP4B	7852.0
AP2A1	7850.0
SAR1B	7795.0
NUP62	7784.0
PCBP2	7782.0
HDAC1	7688.0
PTPN6	7678.0
DAD1	7467.0
TPR	7435.0
STAT1	7294.0
RANBP2	7289.0
MAVS	7199.0
IFIH1	7159.0
IFNA6	7135.0
ST3GAL2	7128.0
ST3GAL1	7090.0
CNBP	7083.0
SNRPD1	7057.0
NUP93	6988.0
ZDHHC5	6937.0
RPS15	6917.0
RPS7	6908.0
FXYD3	6830.0
NUP214	6722.0
PALS1	6697.0
NFKB1	6611.0
AKT1	6607.0
G3BP1	6534.0
RPS18	6474.0
HDAC2	6444.0
RAE1	6386.0
UBB	6377.0
EEF1A1	6294.0
NUP153	6267.0
STT3A	6155.0
CD79B	6090.0
NUP188	6088.0
ITCH	6063.0
VPS11	6041.0
HLA-B	6020.0
UBE2V1	6001.0
AKT2	5870.0
NUP54	5830.0
MAP1LC3B	5812.0
RBX1	5779.0
SAP30	5739.0
RIPK2	5736.0
GATAD2A	5722.0
RB1	5689.0
EP300	5668.0
SEC23A	5642.0
PTPN11	5640.0
RPS6	5583.0
CHMP2A	5566.0
VPS33A	5529.0
VPS41	5508.0
NUP133	5499.0
SEC24A	5482.0
VCP	5453.0
SMAD4	5313.0
IRF3	5278.0
ANO9	5173.0
FXYD4	5144.0
JAK3	5080.0
PARP4	5077.0
SIKE1	5076.0
ARID4A	5020.0
MASP2	5017.0
PYCARD	4931.0
MGAT1	4900.0
NUP58	4880.0
AAAS	4718.0
LARP1	4613.0
SP1	4581.0
MTA1	4534.0
MGAT5	4389.0
NUP107	4332.0
ANO7	4328.0
MASP1	4288.0
NDC1	4258.0
TRAF3	4183.0
CHUK	4148.0
FNTB	4031.0
AP2S1	4029.0
GSK3B	4021.0
RBBP4	3906.0
TOMM70	3776.0
CAV1	3760.0
PRMT1	3725.0
SNRPD3	3720.0
RPS23	3706.0
RPS13	3696.0
GOLGA7	3629.0
MBD3	3615.0
ATP1B3	3607.0
RPS11	3544.0
CSNK1A1	3493.0
CHMP6	3463.0
TBK1	3387.0
EDEM2	3303.0
PATJ	3257.0
GANAB	3184.0
RIPK1	3149.0
SEC24C	3133.0
FUT8	3099.0
TRIM25	3005.0
PHF21A	2921.0
FXYD7	2893.0
SOS1	2865.0
UVRAG	2780.0
NUP43	2770.0
IFNB1	2681.0
GPC1	2591.0
PPIA	2546.0
NR3C1	2470.0
NUP98	2445.0
SDC3	2435.0
RPS21	2412.0
ZCRB1	2379.0
ROCK1	2300.0
PPIH	2293.0
SAP18	2286.0
PIK3C3	2277.0
G3BP2	2271.0
GEMIN2	2137.0
HSP90AB1	2115.0
RPS2	2069.0
NUP160	2051.0
ATP1A3	2017.0
SDC4	1931.0
BLNK	1918.0
MAN1B1	1853.0
ST3GAL3	1802.0
YWHAH	1632.0
ZDHHC2	1621.0
FNTA	1406.0
IFNGR2	1310.0
RPS3	1291.0
KPNA2	1259.0
HMG20B	1213.0
HLA-C	1212.0
YWHAQ	1114.0
ANO6	1091.0
KDM1A	1089.0
TAB2	1079.0
MGAT2	1019.5
NLRP12	976.0
JAK2	952.0
RPN1	944.0
FKBP4	878.0
ST6GALNAC2	766.0
AP2B1	724.0
VEGFA	633.0
RPS27L	566.0
TYK2	306.0
ATP1A1	278.0
SDC2	259.0
RPS9	183.0
CANX	160.0
HAVCR1	142.0
RPS10	102.0
PARP14	-177.0
FKBP1A	-210.0
GPC6	-225.0
RPS3A	-233.0
NRP1	-269.0
RPS26	-319.0
CUL3	-394.0
SNRPB	-401.0
MGAT4A	-459.0
ITGA4	-497.0
BCL2L1	-528.0
ROCK2	-555.0
TRAF6	-626.0
HLA-G	-673.0
NUP35	-710.0
RPS19	-748.0
IFNAR2	-751.0
KEAP1	-855.0
NFKBIA	-865.0
NMI	-893.0
HLA-A	-902.0
RPS25	-928.0
SAP30L	-933.0
SNRPG	-949.0
RPS15A	-1190.0
TLR2	-1307.0
NFE2L2	-1323.0
SUDS3	-1326.0
GRB2	-1330.0
ZDHHC3	-1425.0
CRBN	-1463.0
YWHAG	-1477.0
MAP3K7	-1507.0
AKT3	-1580.0
RPS28	-1593.0
SEC13	-1604.0
SUMO1	-1643.0
SERPINE1	-1662.0
RPS29	-1802.0
TLR1	-1972.0
PARP8	-2021.0
RPN2	-2137.0
JAK1	-2142.0
SRPK2	-2203.0
GEMIN6	-2249.0
GEMIN7	-2369.0
RPS16	-2419.0
MAN2A1	-2420.0
ANO5	-2450.0
RPS27A	-2472.0
IL17RC	-2527.0
ST3GAL4	-2716.0
ARID4B	-2813.0
NCK1	-2888.0
NLRP3	-2898.0
RIPK3	-2933.0
NUP205	-3003.0
SEC24D	-3129.0
BECN1	-3180.0
YWHAE	-3214.0
PARP6	-3228.0
PKLR	-3258.0
HSP90AA1	-3286.0
HSPG2	-3297.0
COMT	-3307.0
ST6GALNAC3	-3321.0
AP2M1	-3365.0
GEMIN5	-3494.0
NUP50	-3509.0
ZDHHC20	-3586.0
MGAT4C	-3605.0
NUP210	-3669.0
MTA2	-3732.0
IFNA5	-3827.0
SEC24B	-3858.0
CHMP3	-3897.0
ATP1A4	-3912.0
POM121	-3922.0
GPC5	-4096.0
TUBB	-4279.0
TJP1	-4334.0
CTSL	-4367.0
IFNA14	-4373.0
SDC1	-4540.0
GJA1	-4611.0
SFN	-4660.0
ATP1A2	-4692.0
VPS18	-4731.0
ANO3	-4733.0
HNRNPA1	-4801.0
ANO1	-4872.0
PPIB	-5006.0
SYK	-5067.0
RPS8	-5241.0
PARP16	-5384.0
IL17RA	-5414.0
CHMP2B	-5574.0
RCOR1	-5587.0
PTGES3	-5736.0
MGAT4B	-5741.0
RPSA	-5754.0
TRIM4	-5899.0
NUP155	-5949.0
CHMP4A	-5994.0
PLCG2	-6046.0
AGRN	-6085.0
IL17A	-6179.0
ZDHHC11	-6205.0
GALNT1	-6215.0
IMPDH1	-6245.0
IRAK2	-6294.0
ANO2	-6297.0
ATP1B1	-6338.0
CASP1	-6717.0
UBE2N	-6780.0
UBC	-6842.0
VPS16	-6919.0
NPM1	-6941.0
VPS45	-6974.0
IFNA21	-7128.0
SNRPE	-7134.0
IL6R	-7164.0
RUNX1	-7252.0
IKBKE	-7451.0
ITGB1	-7482.0
NOD1	-7516.0
RNF135	-7633.0
TKFC	-8012.0
RPS12	-8043.0
POM121C	-8073.0
BST2	-8139.0
ANO4	-8143.0
TMPRSS2	-8173.0
TUSC3	-8180.0
IL1R1	-8298.0
BRD4	-8512.0
MOGS	-8526.0
SMAD3	-8542.0
FURIN	-8937.0
IL17F	-9252.0
CHMP4C	-9374.0
FXYD1	-9554.0
SFTPD	-9589.0
IFNA7	-9606.0
NOD2	-9647.0
STING1	-9782.0
MBL2	-9921.0
FXYD2	-9980.0
IFNA2	-10019.0

---

REACTOME_SNRNP_ASSEMBLY

REACTOME_SNRNP_ASSEMBLY

	322
set	REACTOME_SNRNP_ASSEMBLY
setSize	53
pANOVA	0.000123
s.dist	0.305
p.adjustANOVA	0.00647

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP37	10891.0
PRMT5	10556.0
SNRPD2	10271.0
SNRPF	10159.0
NUP85	10105.0
DDX20	9996.0
NCBP2	9630.0
TGS1	9515.0
NCBP1	9433.0
WDR77	9377.0
GEMIN4	9188.0
SEH1L	8981.0
CLNS1A	8360.0
NUP88	8287.0
NUP42	8255.0
SMN1	8042.5
SMN2	8042.5
NUP62	7784.0
TPR	7435.0
RANBP2	7289.0

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP37	10891.0
PRMT5	10556.0
SNRPD2	10271.0
SNRPF	10159.0
NUP85	10105.0
DDX20	9996.0
NCBP2	9630.0
TGS1	9515.0
NCBP1	9433.0
WDR77	9377.0
GEMIN4	9188.0
SEH1L	8981.0
CLNS1A	8360.0
NUP88	8287.0
NUP42	8255.0
SMN1	8042.5
SMN2	8042.5
NUP62	7784.0
TPR	7435.0
RANBP2	7289.0
SNRPD1	7057.0
NUP93	6988.0
NUP214	6722.0
RAE1	6386.0
NUP153	6267.0
NUP188	6088.0
NUP54	5830.0
NUP133	5499.0
NUP58	4880.0
AAAS	4718.0
PHAX	4608.0
NUP107	4332.0
NDC1	4258.0
SNRPD3	3720.0
NUP43	2770.0
NUP98	2445.0
GEMIN2	2137.0
NUP160	2051.0
SNRPB	-401.0
NUP35	-710.0
SNRPG	-949.0
SNUPN	-1115.0
SEC13	-1604.0
GEMIN6	-2249.0
GEMIN7	-2369.0
NUP205	-3003.0
GEMIN5	-3494.0
NUP50	-3509.0
NUP210	-3669.0
POM121	-3922.0
NUP155	-5949.0
SNRPE	-7134.0
POM121C	-8073.0

---

REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

	973
set	REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS
setSize	418
pANOVA	0.000126
s.dist	0.109
p.adjustANOVA	0.00647

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LCK	11679
CD19	11678
DKK4	11567
PSMD3	11142
HDAC5	11105
VAV1	11098
SYVN1	11015
PPP2R5D	10754
CSK	10710
EIF2AK3	10539
RAC2	10466
TLN1	10454
PSMC1	10399
HDAC10	10397
TRIP11	10388
BCL2L11	10226
GTF2F1	10225
PSMB1	10173
POLR2E	10170
UBA52	10169

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LCK	11679
CD19	11678
DKK4	11567
PSMD3	11142
HDAC5	11105
VAV1	11098
SYVN1	11015
PPP2R5D	10754
CSK	10710
EIF2AK3	10539
RAC2	10466
TLN1	10454
PSMC1	10399
HDAC10	10397
TRIP11	10388
BCL2L11	10226
GTF2F1	10225
PSMB1	10173
POLR2E	10170
UBA52	10169
PDPK1	10091
KIF5B	10054
DLL4	9986
MYO18A	9927
FLT3LG	9918
PSMC6	9892
DUSP16	9820
BIN2	9781
CEBPB	9779
RAP1B	9757
LMNA	9748
CAMK2G	9730
SMAD2	9684
NCBP2	9630
PSENEN	9567
TGFBR1	9558
ITGA2B	9472
FGF22	9453
NCBP1	9433
SPRED3	9310
PPP2R5A	9306
BIRC6	9264
PSMD4	9234
ZFYVE9	9200
CCNC	9187
STAT3	9135
MPRIP	9131
CLTC	8900
ACTB	8836
YWHAB	8801
ACTG1	8780
CPSF6	8756
PSME3	8732
HDAC3	8661
POLR2D	8613
DUSP7	8593
VCL	8514
CREBBP	8505
JAG2	8496
PSMD13	8389
FGF5	8332
WDCP	8309
ZC3HAV1	8296
FGF6	8209
PEBP1	8150
MAP2K1	8096
FGA	8035
PSMC3	7956
ERBB3	7954
NRAS	7875
GSK3A	7873
HEY2	7797
PSMA3	7703
HDAC1	7688
CD28	7686
AKAP9	7637
FRS2	7490
TPR	7435
PSMD7	7334
PSEN1	7325
APBB1IP	7319
CREB1	7306
STAT1	7294
RANBP2	7289
PIK3CD	7276
AGGF1	7256
FBXW7	7200
EREG	7091
PRKAR1A	7017
EML4	6970
FGF2	6920
ATIC	6901
PSMA7	6898
PSMA1	6861
DHH	6822
KDM7A	6808
TRAK1	6617
DUSP6	6610
AKT1	6607
PSMB2	6549
PSMC4	6484
FIP1L1	6458
HDAC2	6444
UBB	6377
KLC1	6303
CNTRL	6286
PSMD9	6250
SRC	6197
DCTN1	6189
NCOR1	6071
APH1A	6068
PPP2R5B	6021
PSMD14	5956
AGK	5951
MYC	5940
FGF9	5906
CTNNB1	5893
AKT2	5870
ESR2	5832
RAF1	5793
RBX1	5779
PSMA6	5773
ADAM10	5772
EP300	5668
PTPN11	5640
RPS6	5583
NCSTN	5565
VCP	5453
PSME2	5380
KREMEN1	5321
PSMD11	5320
SMAD4	5313
GCC2	5259
POLR2I	5240
TPM3	5234
BRAP	5133
JUNB	5088
CDKN1B	5083
PSMB5	5052
POLR2A	5042
CALM1	5021
MYH9	4989
SNW1	4927
RPS6KB2	4840
PSMB3	4835
PPP2R1B	4800
ESRP1	4762
FGF10	4692
PLCG1	4604
CARS1	4596
KAT2A	4523
SND1	4487
JAG1	4477
PPP1CB	4467
IRS2	4442
FGF20	4406
MAP2K2	4356
SEC31A	4349
CDK8	4344
FZD5	4282
CAMK2B	4182
PIK3CA	4175
PSME4	4171
CHUK	4148
POLR2F	4146
PPP2R5C	4099
MDM2	4051
GSK3B	4021
SHOC2	3979
STAT5B	3960
FGFR4	3935
PSMD12	3928
BTC	3853
ARRB2	3835
IHH	3787
TGFBR2	3758
POLR2H	3756
KL	3732
KREMEN2	3721
RAP1A	3718
PSMD5	3711
RBPJ	3704
PSMB8	3681
MAML3	3654
PSMA4	3640
MARK3	3628
NF1	3618
TSC2	3609
HDAC4	3576
FAM131B	3505
CSNK1A1	3493
FGB	3371
IQGAP1	3357
ARRB1	3085
PSMD1	3063
PIK3R3	3043
CEP43	3035
NOTCH1	2914
SOS1	2865
LRRFIP1	2863
WNT3A	2856
TNKS	2784
LRP6	2743
DERL2	2662
GAB2	2647
DLL1	2611
HDAC11	2567
MIB1	2557
ERBB4	2545
RICTOR	2329
PPP2R5E	2327
VWF	2325
RRBP1	2324
PSMB9	2322
APC	2233
SPTBN1	2163
MAPK3	2077
KLB	2055
APH1B	2027
MAPKAP1	2024
BRAF	2001
HEY1	1919
KANK1	1859
NEURL1	1707
SHH	1614
PTEN	1587
CBL	1574
PSMC5	1519
SKP1	1470
MAML1	1461
ETV6	1451
CUX1	1363
PPP2CA	1345
RNF213	1338
EPGN	1237
TENT4A	1232
MTOR	1229
SEL1L	1220
STRN	1201
MIB2	1138
FGF19	1105
DUSP8	1104
AP3B1	1085
POLR2B	1016
PSEN2	989
JAK2	952
AXIN1	936
MAPK1	915
PPP2R1A	849
HES1	805
FGF18	748
FOXO3	729
TGFB1	696
PIK3R2	686
TBL1XR1	644
NEURL1B	512
TRIM24	453
TRAT1	420
HES5	378
PDGFA	242
PHB1	63
PSMF1	4
PPM1B	-24
HRAS	-31
RNF43	-53
NOX4	-69
OS9	-137
CNKSR1	-176
FKBP1A	-210
POLR2G	-351
ERBB2	-402
FGF23	-421
SEM1	-434
GOLGA4	-442
BCL2L1	-528
FXR1	-580
HIP1	-650
POLR2K	-795
GAB1	-805
PSMC2	-844
ERLEC1	-889
FGG	-894
FGF3	-930
CTBP2	-973
GOLGB1	-1078
TNKS2	-1105
HEYL	-1147
QKI	-1149
PRR5	-1177
ALK	-1317
GRB2	-1330
PIM1	-1362
FGFR1	-1379
PPFIBP1	-1443
POLR2C	-1547
ITGB3	-1557
AKT3	-1580
WDR48	-1608
EGF	-1667
BAG4	-1668
NRG2	-1726
CDC37	-1768
SQSTM1	-1966
ERBIN	-2075
MLST8	-2078
BAD	-2110
MET	-2113
FGF17	-2121
KSR2	-2194
PSMD6	-2201
CDKN1A	-2242
MAML2	-2253
PTPN12	-2285
PSMD8	-2294
LYN	-2322
YES1	-2333
CD80	-2384
RPS27A	-2472
FAM114A2	-2502
FZD6	-2690
PSMA2	-2726
PIK3R1	-2742
RAC1	-2752
IRS1	-2755
ADAM17	-2880
TFG	-2891
FN1	-2929
FGFR1OP2	-2945
GTF2F2	-3076
PSMB4	-3191
PIK3CB	-3212
HSP90AA1	-3286
PPP1CC	-3357
PSMA8	-3478
LRP5	-3485
AKT1S1	-3551
ZMYM2	-3589
DKK1	-3604
KDR	-3623
KAT2B	-3652
MAP3K11	-3722
BCL2A1	-3734
ZC3HC1	-3768
CLCN6	-3797
ESR1	-3799
LMO7	-3805
HBEGF	-3838
ERLIN2	-3845
KITLG	-3872
PAPSS1	-3924
MRAS	-3959
PSMB10	-3966
CAMK2A	-4043
NRG1	-4113
FZD4	-4123
PDGFRA	-4229
PSMA5	-4274
FGFR2	-4518
TCF7L2	-4535
CTBP1	-4646
DKK2	-4714
SPRED2	-4750
PSMB6	-4786
SHC1	-4863
DUSP10	-4970
NCOR2	-5218
PSMB7	-5258
FGF1	-5409
CAMK2D	-5437
FZD8	-5463
KIT	-5560
FRS3	-5568
BCL11A	-5637
FLT3	-5698
HDAC7	-5767
FYN	-5782
FGF7	-5924
FOXO1	-5960
HHAT	-5973
PDGFB	-6088
RHOG	-6108
PDGFRB	-6138
FGFR3	-6141
PPP2CB	-6157
PSMD2	-6176
CUL1	-6388
HGF	-6494
FGF8	-6616
NRG4	-6629
CASP9	-6765
UBC	-6842
KIAA1549	-6845
EEF1G	-6875
NPM1	-6941
TGFA	-6980
TPM4	-7011
CD86	-7049
FGF4	-7080
SPRED1	-7085
HDAC9	-7248
ATG7	-7371
AREG	-7512
BCR	-7617
KRAS	-7660
POLR2L	-7683
PSME1	-7763
KSR1	-7764
NR4A1	-7934
EGFR	-7980
PSMB11	-8541
SMAD3	-8542
STAT5A	-8548
FOXO6	-8616
NRG3	-8684
PIK3AP1	-8790
ICOS	-9358
POLR2J	-9382
AGTRAP	-9704

---

REACTOME_RRNA_PROCESSING

REACTOME_RRNA_PROCESSING

	1148
set	REACTOME_RRNA_PROCESSING
setSize	192
pANOVA	0.000137
s.dist	0.16
p.adjustANOVA	0.0068

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL39L	11403
THUMPD1	11299
UTP14C	11061
WDR3	11008
PWP2	10897
EXOSC9	10825
WDR12	10786
RPS24	10632
EXOSC3	10479
EBNA1BP2	10362
NIP7	10306
UBA52	10169
HEATR1	10026
TSR1	10023
NOP2	10004
RPL26	9894
RPL27	9834
RIOK2	9769
NCL	9768
RPP38	9763

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL39L	11403.0
THUMPD1	11299.0
UTP14C	11061.0
WDR3	11008.0
PWP2	10897.0
EXOSC9	10825.0
WDR12	10786.0
RPS24	10632.0
EXOSC3	10479.0
EBNA1BP2	10362.0
NIP7	10306.0
UBA52	10169.0
HEATR1	10026.0
TSR1	10023.0
NOP2	10004.0
RPL26	9894.0
RPL27	9834.0
RIOK2	9769.0
NCL	9768.0
RPP38	9763.0
RRP7A	9602.0
NAT10	9505.0
KRR1	9396.0
RPP40	9124.0
WDR43	9091.0
NOP14	8952.0
MRM3	8833.0
DHX37	8774.0
DIS3	8527.0
RPL10A	8486.0
RPS14	8357.0
RPL24	8299.0
UTP4	8272.0
RPS20	8266.0
RPS27	8146.0
EXOSC8	8126.0
FAU	8073.0
RPS5	8053.0
RPL35	7924.0
SNU13	7775.0
ELAC2	7603.0
RPL36	7593.0
RRP36	7576.0
DCAF13	7394.0
MRM2	7154.0
NHP2	7105.0
TRMT10C	7032.0
EXOSC10	6925.0
RPS15	6917.0
RPS7	6908.0
RPL22	6685.0
EXOSC6	6642.0
RPL37A	6589.0
RPL5	6546.0
RPS18	6474.0
NOC4L	6373.0
RPP21	6307.0
EXOSC2	6293.0
WDR46	6282.0
BMS1	6062.0
GAR1	5979.0
RPP25	5963.0
RPS6	5583.0
FBL	5371.0
RPL13	5324.0
TEX10	5308.0
CSNK1D	5214.0
IMP3	5186.0
RPL18	5130.0
EXOSC5	5051.0
RPL11	5014.0
NOB1	4999.0
RPLP2	4945.0
RPL37	4942.0
RPL7	4893.0
RPL19	4852.0
LTV1	4801.0
RPL3L	4652.0
UTP18	4026.0
RPL8	4020.0
RBM28	3998.0
MPHOSPH6	3791.0
RPS23	3706.0
RPS13	3696.0
MRM1	3676.0
NOL9	3663.0
MPHOSPH10	3623.0
RPS11	3544.0
RPLP0	3496.0
DDX52	3393.0
XRN2	3245.0
FTSJ3	3040.0
TRMT112	2809.0
TFB1M	2592.0
NOP10	2587.0
ISG20L2	2585.0
RPL27A	2534.0
RPS21	2412.0
RPL30	2387.0
RPL35A	2255.0
RPS2	2069.0
RPL3	2052.0
DDX49	2004.0
TBL3	1987.0
TSR3	1974.0
WDR36	1884.0
RPL18A	1823.0
RPL7A	1463.0
UTP11	1318.0
NSUN4	1296.0
RPS3	1291.0
EXOSC4	1271.0
RIOK1	1160.0
NOP58	1062.0
RPL36AL	1019.5
UTP15	928.0
RPP14	904.0
RPS27L	566.0
PDCD11	559.0
RPL26L1	476.0
RPL6	325.0
BYSL	209.0
RPS9	183.0
RPS10	102.0
MTERF4	-21.0
SENP3	-66.0
RPS3A	-233.0
RPS26	-319.0
PELP1	-455.0
IMP4	-460.0
RPL9	-564.0
PRORP	-651.0
NOL6	-716.0
RPS19	-748.0
RPS25	-928.0
DDX21	-1067.0
RPL17	-1074.0
RPS15A	-1190.0
RPL31	-1191.0
RPL41	-1400.0
UTP3	-1415.0
RPL21	-1464.0
RPS28	-1593.0
WDR75	-1596.0
UTP6	-1641.0
MTREX	-1644.0
RPS29	-1802.0
RPL4	-1976.0
UTP20	-1990.0
RPL14	-2101.0
DIMT1	-2319.0
RIOK3	-2388.0
RPS16	-2419.0
RPS27A	-2472.0
C1D	-2500.0
NOL11	-2551.0
RRP9	-2578.0
EXOSC7	-2604.0
GNL3	-2739.0
PNO1	-2790.0
NOP56	-2797.0
EMG1	-2798.0
FCF1	-2838.0
UTP25	-2959.0
RPLP1	-3066.0
RPL12	-3217.0
RPL38	-3220.0
RPL32	-3366.0
BUD23	-3396.0
RPL28	-3461.0
EXOSC1	-3957.0
RPL15	-4110.0
WDR18	-4242.0
PES1	-4261.0
RPL29	-4307.0
BOP1	-4666.0
RPL22L1	-5004.0
RPS8	-5241.0
NOL12	-5293.0
RRP1	-5326.0
DDX47	-5362.0
RPSA	-5754.0
RPL34	-6070.0
ERI1	-6509.0
RCL1	-6667.0
RPP30	-7497.0
RPL23	-7518.0
RPL13A	-7929.5
RPS12	-8043.0
RPL23A	-8127.0
CSNK1E	-8775.0
RPL10L	-9546.0

---

REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

	1145
set	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM
setSize	78
pANOVA	0.000174
s.dist	0.246
p.adjustANOVA	0.00839

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GLE1	11355
DDX39B	11243
SARNP	11065
NUP37	10891
SRRM1	10636
CPSF1	10424
NUP85	10105
U2AF1L4	9713
NCBP2	9630
NCBP1	9433
SRSF1	9323
NXF1	9220
SEH1L	8981
MAGOHB	8573
CDC40	8444
NUP88	8287
NUP42	8255
NUP62	7784
TPR	7435
CPSF4	7318

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GLE1	11355
DDX39B	11243
SARNP	11065
NUP37	10891
SRRM1	10636
CPSF1	10424
NUP85	10105
U2AF1L4	9713
NCBP2	9630
NCBP1	9433
SRSF1	9323
NXF1	9220
SEH1L	8981
MAGOHB	8573
CDC40	8444
NUP88	8287
NUP42	8255
NUP62	7784
TPR	7435
CPSF4	7318
RANBP2	7289
THOC1	7060
DHX38	7051
NUP93	6988
NUP214	6722
FIP1L1	6458
RAE1	6386
WDR33	6333
CPSF2	6288
NUP153	6267
NUP188	6088
NUP54	5830
NUP133	5499
THOC6	5090
THOC5	5071
NUP58	4880
AAAS	4718
SLBP	4710
ZC3H11A	4653
FYTTD1	4619
SLU7	4525
SRSF3	4433
NUP107	4332
NDC1	4258
SRSF9	4130
SRSF6	3503
EIF4E	3219
NUP43	2770
NUP98	2445
NUP160	2051
THOC7	1161
SRSF2	951
SRSF11	669
U2AF2	490
CASC3	449
ALYREF	429
SRSF4	47
RBM8A	-178
RNPS1	-231
POLDIP3	-663
NUP35	-710
SEC13	-1604
MAGOH	-1713
SRSF5	-2055
DDX39A	-2492
EIF4A3	-2617
NUP205	-3003
NUP50	-3509
NUP210	-3669
POM121	-3922
CHTOP	-4796
SRSF7	-4925
NXT1	-5022
CPSF3	-5038
NUP155	-5949
SYMPK	-6153
THOC3	-6299
POM121C	-8073

---

REACTOME_S_PHASE

REACTOME_S_PHASE

	1110
set	REACTOME_S_PHASE
setSize	159
pANOVA	0.000203
s.dist	0.171
p.adjustANOVA	0.00953

Top enriched genes

Top 20 genes

GeneID	Gene Rank
E2F4	11443
PSMD3	11142
LIN37	11039
POLA2	10669
PSMC1	10399
PCNA	10230
PSMB1	10173
UBA52	10169
PSMC6	9892
ORC1	9866
CDC23	9833
ORC6	9596
PSMD4	9234
RPA3	9109
FEN1	8951
POLE	8919
DNA2	8886
TFDP2	8771
PSME3	8732
POLD1	8554

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
E2F4	11443
PSMD3	11142
LIN37	11039
POLA2	10669
PSMC1	10399
PCNA	10230
PSMB1	10173
UBA52	10169
PSMC6	9892
ORC1	9866
CDC23	9833
ORC6	9596
PSMD4	9234
RPA3	9109
FEN1	8951
POLE	8919
DNA2	8886
TFDP2	8771
PSME3	8732
POLD1	8554
ANAPC10	8406
PSMD13	8389
E2F1	8248
RPA1	8165
PRIM1	7996
PSMC3	7956
MAX	7890
PSMA3	7703
CDK4	7586
GINS2	7478
LIN52	7370
PSMD7	7334
PDS5A	7273
MCM5	7141
PSMA7	6898
PSMA1	6861
AKT1	6607
PSMB2	6549
PSMC4	6484
UBB	6377
MCM7	6360
CDC16	6332
PSMD9	6250
TFDP1	6154
SKP2	6108
PSMD14	5956
MYC	5940
AKT2	5870
RBX1	5779
PSMA6	5773
RB1	5689
ESCO1	5626
ESCO2	5535
CDCA5	5505
MCM8	5436
PSME2	5380
PSMD11	5320
UBE2S	5276
CDC26	5157
RFC2	5115
ANAPC1	5092
CDKN1B	5083
PSMB5	5052
PSMB3	4835
GINS1	4752
CKS1B	4659
RPA2	4484
RBL2	4475
ORC4	4299
PSME4	4171
GSK3B	4021
PSMD12	3928
RBBP4	3906
CCNE2	3867
ANAPC7	3809
PSMD5	3711
PSMB8	3681
PSMA4	3640
ORC2	3590
RFC4	3563
ANAPC5	3355
FZR1	3328
ANAPC4	3312
CDK7	3307
MCM3	3239
STAG1	3161
PSMD1	3063
CDC25B	2961
ORC5	2938
GMNN	2913
RAD21	2837
CDC27	2701
SMC3	2481
WEE1	2466
RFC3	2420
PSMB9	2322
PDS5B	2276
RFC1	2245
ANAPC2	1989
CCNA2	1874
CCND1	1840
GINS4	1702
PSMC5	1519
CDC6	1513
SKP1	1470
UBE2D1	1355
CDC45	1297
POLE2	1257
LIG1	1254
MNAT1	1066
WAPL	929
LIN54	826
ORC3	791
MCM2	327
CDC25A	220
PSMF1	4
SEM1	-434
PSMC2	-844
PRIM2	-897
CDT1	-944
AKT3	-1580
MCM4	-1749
PSMD6	-2201
CDKN1A	-2242
PSMD8	-2294
E2F5	-2329
RPS27A	-2472
ANAPC11	-2624
PSMA2	-2726
PSMB4	-3191
POLD3	-3223
PSMA8	-3478
PTK6	-3658
PSMB10	-3966
ANAPC16	-4002
CCNE1	-4003
RFC5	-4136
ANAPC15	-4142
MCM6	-4245
PSMA5	-4274
CCNA1	-4580
PSMB6	-4786
POLE3	-4968
PSMB7	-5258
UBE2C	-5371
POLD2	-5490
LIN9	-5919
PSMD2	-6176
POLD4	-6372
CUL1	-6388
CDK2	-6684
UBC	-6842
CCNH	-7541
UBE2E1	-7595
PSME1	-7763
POLE4	-8070
GINS3	-8210
PSMB11	-8541
CABLES1	-8728

---

REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS

REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS

	810
set	REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS
setSize	86
pANOVA	0.000211
s.dist	0.231
p.adjustANOVA	0.00962

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ZFP36	11423
PSMD3	11142
EXOSC9	10825
EXOSC3	10479
PSMC1	10399
ZFP36L1	10195
PSMB1	10173
UBA52	10169
MAPK14	10146
PSMC6	9892
XPO1	9708
ELAVL1	9604
EIF4G1	9315
PSMD4	9234
KHSRP	8971
YWHAB	8801
PSME3	8732
DIS3	8527
PSMD13	8389
YWHAZ	8195

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ZFP36	11423
PSMD3	11142
EXOSC9	10825
EXOSC3	10479
PSMC1	10399
ZFP36L1	10195
PSMB1	10173
UBA52	10169
MAPK14	10146
PSMC6	9892
XPO1	9708
ELAVL1	9604
EIF4G1	9315
PSMD4	9234
KHSRP	8971
YWHAB	8801
PSME3	8732
DIS3	8527
PSMD13	8389
YWHAZ	8195
EXOSC8	8126
PARN	8054
PSMC3	7956
PSMA3	7703
PSMD7	7334
PSMA7	6898
PSMA1	6861
NUP214	6722
EXOSC6	6642
AKT1	6607
PSMB2	6549
PSMC4	6484
UBB	6377
EXOSC2	6293
PSMD9	6250
PSMD14	5956
PSMA6	5773
ANP32A	5599
PSME2	5380
PSMD11	5320
PSMB5	5052
EXOSC5	5051
PSMB3	4835
HNRNPD	4380
PSME4	4171
PSMD12	3928
PSMD5	3711
PSMB8	3681
PSMA4	3640
PSMD1	3063
PSMB9	2322
MAPK11	2152
HSPA8	2120
DCP1A	1817
DCP2	1742
PSMC5	1519
EXOSC4	1271
XRN1	1110
MAPKAPK2	775
PRKCD	733
PSMF1	4
SEM1	-434
TNPO1	-470
PRKCA	-589
PSMC2	-844
PABPC1	-955
PSMD6	-2201
PSMD8	-2294
RPS27A	-2472
EXOSC7	-2604
PSMA2	-2726
PSMB4	-3191
PSMA8	-3478
HSPA1A	-3563
EXOSC1	-3957
PSMB10	-3966
SET	-4012
PSMA5	-4274
PSMB6	-4786
PSMB7	-5258
HSPB1	-6020
PSMD2	-6176
UBC	-6842
PSME1	-7763
PSMB11	-8541
TNFSF13	-9435

---

REACTOME_REGULATION_OF_TP53_ACTIVITY

REACTOME_REGULATION_OF_TP53_ACTIVITY

	926
set	REACTOME_REGULATION_OF_TP53_ACTIVITY
setSize	156
pANOVA	0.000236
s.dist	0.171
p.adjustANOVA	0.0105

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RFFL	11154
POU4F2	10799
DAXX	10654
PRMT5	10556
USP2	10472
RNF34	10341
MEAF6	10219
UBA52	10169
MAPK14	10146
PDPK1	10091
ATR	10067
TAF15	10036
TAF12	10008
PRKAA1	9578
SETD9	9577
TP53	9551
PPP1R13L	9498
RMI1	9316
CSNK2A1	9219
BRPF1	9147

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RFFL	11154
POU4F2	10799
DAXX	10654
PRMT5	10556
USP2	10472
RNF34	10341
MEAF6	10219
UBA52	10169
MAPK14	10146
PDPK1	10091
ATR	10067
TAF15	10036
TAF12	10008
PRKAA1	9578
SETD9	9577
TP53	9551
PPP1R13L	9498
RMI1	9316
CSNK2A1	9219
BRPF1	9147
RPA3	9109
RAD9B	9100
GATAD2B	8932
DNA2	8886
RAD9A	8617
PIP4P1	8609
HIPK1	8483
CHD3	8412
STK11	8335
CHD4	8242
RPA1	8165
POU4F1	7961
NOC2L	7862
WRN	7786
PIP4K2B	7785
HDAC1	7688
TBP	7543
RAD50	7503
CHEK1	7457
USP7	7118
TAF9	6942
TOP3A	6789
AKT1	6607
PML	6494
ATM	6477
HDAC2	6444
UBB	6377
CDK1	6313
AKT2	5870
GATAD2A	5722
EP300	5668
CHEK2	5205
PHF20	5189
RFC2	5115
BANP	4905
PPP1R13B	4877
PPP2R1B	4800
SUPT16H	4733
RPA2	4484
AURKB	4455
PRKAG3	4451
PPP2R5C	4099
ING2	4091
MDM2	4051
PRKAB1	3970
MAP2K6	3919
TOPBP1	3907
RBBP4	3906
CDKN2A	3849
RAD17	3845
TAF2	3833
CSNK2B	3763
HIPK2	3717
MBD3	3615
NBN	3589
RFC4	3563
DYRK2	3062
BRD7	2958
AURKA	2948
PIN1	2737
RFC3	2420
SSRP1	2333
RICTOR	2329
MAPK11	2152
MAPKAP1	2024
BRPF3	2008
SMYD2	1940
CCNA2	1874
RMI2	1748
MDM4	1716
EHMT2	1533
BRCA1	1471
PPP2CA	1345
ZNF385A	1287
MTOR	1229
RBBP8	1178
PRKAG1	875
PPP2R1A	849
TP73	845
ING5	838
TAF3	788
CSNK2A2	723
TAF13	443
PRKAG2	412
KMT5A	190
JMY	49
TAF10	-28
EHMT1	-280
EXO1	-290
MRE11	-382
RAD1	-410
BRD1	-440
TAF4	-484
PRDM1	-686
TAF5	-1088
PRR5	-1177
HUS1	-1275
KAT6A	-1324
PIP4K2C	-1350
AKT3	-1580
PRKAB2	-1585
MAPKAPK5	-1948
BLM	-1963
MLST8	-2078
TTC5	-2091
TAF4B	-2117
BARD1	-2156
CDK5	-2315
CDK5R1	-2377
RPS27A	-2472
TP53RK	-2553
RHNO1	-2686
TP53INP1	-3087
TAF11	-3192
PLK3	-3410
TP53BP2	-3693
TPX2	-3710
MTA2	-3732
RFC5	-4136
BRIP1	-4248
PRKAA2	-4524
CCNA1	-4580
KAT5	-4633
ATRIP	-4882
L3MBTL1	-4987
PPP2CB	-6157
CCNG1	-6312
PIP4K2A	-6480
SGK1	-6558
CDK2	-6684
TAF7	-6785
UBC	-6842
TP63	-7582
TAF1L	-8088
NUAK1	-8604
TAF6	-9176

---

REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

	822
set	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS
setSize	46
pANOVA	0.000259
s.dist	0.311
p.adjustANOVA	0.0112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NUP37	10891
PIAS4	10486
UBE2I	10324
PCNA	10230
NUP85	10105
SEH1L	8981
BIRC5	8644
SUMO2	8422
NUP88	8287
NUP42	8255
NUP62	7784
TPR	7435
RANBP2	7289
TOP2B	7207
SUMO3	7150
NUP93	6988
NUP214	6722
RAE1	6386
NUP153	6267
NUP188	6088

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NUP37	10891
PIAS4	10486
UBE2I	10324
PCNA	10230
NUP85	10105
SEH1L	8981
BIRC5	8644
SUMO2	8422
NUP88	8287
NUP42	8255
NUP62	7784
TPR	7435
RANBP2	7289
TOP2B	7207
SUMO3	7150
NUP93	6988
NUP214	6722
RAE1	6386
NUP153	6267
NUP188	6088
NUP54	5830
RANGAP1	5723
NUP133	5499
TOP1	5250
NUP58	4880
AAAS	4718
AURKB	4455
NUP107	4332
NDC1	4258
INCENP	3298
TOP2A	3104
AURKA	2948
NUP43	2770
NUP98	2445
NUP160	2051
CDCA8	1598
PIAS3	-565
NUP35	-710
SEC13	-1604
SUMO1	-1643
NUP205	-3003
NUP50	-3509
NUP210	-3669
POM121	-3922
NUP155	-5949
POM121C	-8073

---

REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

	116
set	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION
setSize	291
pANOVA	0.000377
s.dist	-0.121
p.adjustANOVA	0.0159

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTSG	-9867
LUM	-9833
MUSK	-9507
PCOLCE2	-9204
PXDN	-9103
CAPN14	-9080
CTSD	-9046
ADAMTS16	-8974
CEACAM8	-8954
FURIN	-8937
MFAP4	-8923
ITGA5	-8904
FMOD	-8857
ITGAX	-8710
TNR	-8608
ICAM2	-8577
ELANE	-8567
COL22A1	-8416
PLG	-8410
DSPP	-8357

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTSG	-9867
LUM	-9833
MUSK	-9507
PCOLCE2	-9204
PXDN	-9103
CAPN14	-9080
CTSD	-9046
ADAMTS16	-8974
CEACAM8	-8954
FURIN	-8937
MFAP4	-8923
ITGA5	-8904
FMOD	-8857
ITGAX	-8710
TNR	-8608
ICAM2	-8577
ELANE	-8567
COL22A1	-8416
PLG	-8410
DSPP	-8357
LAMB3	-8264
MMP16	-8008
MMP14	-8003
CAPN13	-7876
PHYKPL	-7859
ADAMTS9	-7672
OPTC	-7661
ITGAM	-7654
ITGB1	-7482
THBS1	-7436
TTR	-7413
TLL1	-7281
ADAMTS2	-7149
MFAP2	-7136
MMP7	-6946
GDF5	-6916
SPARC	-6899
MMP13	-6839
HAPLN1	-6809
COL20A1	-6726
ADAMTS14	-6721
COL6A6	-6597
FBN3	-6595
TGFB2	-6559
KLKB1	-6527
ADAM12	-6479
COL6A3	-6462
KLK2	-6349
ADAMTS1	-6344
COL5A1	-6342
MMP2	-6333
CMA1	-6314
ITGA7	-6252
ITGB8	-6182
BMP10	-6128
TNC	-6113
COL12A1	-6101
LOXL2	-6091
PDGFB	-6088
AGRN	-6085
P3H2	-6079
TGFB3	-5988
NCAM1	-5916
COL4A2	-5905
LTBP1	-5819
LOXL1	-5715
COL19A1	-5573
MMP1	-5559
COL9A2	-5516
PLOD1	-5509
COL27A1	-5435
HTRA1	-5378
DMP1	-5373
ADAM8	-5358
COL25A1	-5339
FBN2	-5163
ELN	-5123
VCAN	-5103
SPOCK3	-5101
PLEC	-5058
PPIB	-5006
CAPN2	-5001
ADAM19	-4948
TNXB	-4912
ITGA3	-4906
ADAMTS18	-4814
SPP1	-4765
COL13A1	-4698
CAPN8	-4678
CTRB2	-4623
SDC1	-4540
CTSL	-4367
NID1	-4361
ITGAD	-4254
PLOD2	-4230
ASPN	-4226
LAMA1	-4189
CAPN5	-4093
LAMC1	-4032
COL9A1	-3784
COLGALT2	-3714
LAMA2	-3637
KDR	-3623
COL11A2	-3562
PECAM1	-3505
COL6A1	-3349
HSPG2	-3297
TNN	-3246
DCN	-3245
MATN3	-3239
ACAN	-3157
EMILIN1	-3145
CAPN9	-3016
CAPN7	-3006
NID2	-2996
COL2A1	-2938
FN1	-2929
ICAM4	-2926
COL26A1	-2923
ADAM17	-2880
COL6A2	-2552
ITGB5	-2538
COL17A1	-2486
NRXN1	-2432
LRP4	-2425
COL28A1	-2381
BMP4	-2196
MMP12	-2125
PTPRS	-2098
CTSV	-2071
MFAP3	-2027
IBSP	-2024
CRTAP	-1979
DDR2	-1918
CAPN12	-1869
MMP20	-1860
COL24A1	-1854
SERPINH1	-1788
SERPINE1	-1662
ITGA1	-1636
A2M	-1610
COL1A2	-1569
ITGB3	-1557
MMP9	-1455
JAM3	-1392
ADAMTS3	-1387
LAMA4	-1320
CAPNS1	-1294
COL5A3	-1157
LAMB1	-1090
ADAM15	-1003
SH3PXD2A	-939
FGG	-894
CAPN3	-870
COL15A1	-743
CDH1	-689
COL4A1	-634
PRKCA	-589
ITGA4	-497
ITGB7	-449
MMP11	-391
MADCAM1	-311
TRAPPC4	-184
FBLN1	32
COL23A1	43
SCUBE1	128
DST	210
PDGFA	242
DAG1	257
SDC2	259
KLK7	543
COL8A1	563
NTN4	623
PLOD3	631
JAM2	658
TGFB1	696
COL5A2	711
BMP7	857
COL18A1	942
ADAM9	1010
LAMC3	1056
ADAMTS8	1145
ITGA11	1416
APP	1473
P4HA3	1526
COL1A1	1543
LOX	1555
LAMB2	1584
FBLN2	1631
ITGAV	1791
CAPN10	1815
COL9A3	1887
SDC4	1931
COL21A1	2007
TIMP2	2070
CTSK	2090
MMP24	2161
MMP17	2207
COL4A4	2254
BMP1	2316
VWF	2325
ITGA2	2338
ITGAE	2393
SDC3	2435
ITGA9	2475
ADAMTS4	2533
NCAN	2612
MATN4	2727
LAMC2	2744
FBN1	2787
CTSB	2805
MMP19	2829
COL16A1	3042
CEACAM1	3131
MMP25	3247
ITGB6	3248
FGB	3371
COL6A5	3521
EMILIN2	3569
F11R	3591
MMP15	3646
P4HA2	3932
EFEMP1	4246
BMP2	4255
CD151	4376
CEACAM6	4456
LTBP2	4549
COMP	5010
PCOLCE	5058
VTN	5218
P3H1	5310
CAPN15	5411
NCSTN	5565
VCAM1	5678
P3H3	5759
ADAM10	5772
LTBP4	6217
FBLN5	6265
COL3A1	6367
CASP3	6396
COL7A1	6429
P4HA1	6528
COL10A1	6605
COL14A1	6786
ADAMTS5	6796
CD47	6815
BSG	6867
ACTN1	6903
CAST	6904
FGF2	6920
ITGAL	6976
CAPNS2	7093
MFAP5	7100
PSEN1	7325
LOXL3	7328
MATN1	7379
SCUBE3	7383
CD44	7396
MMP8	7400
ICAM1	7440
TLL2	7458
CAPN1	7465
LOXL4	7487
BCAN	7522
CTRB1	7755
LTBP3	7899
FGA	8035
LAMA5	8115
COL4A3	8355
ITGA8	8439
ITGA6	8772
ICAM5	8887
MMP10	8897
ITGB4	8921
EMILIN3	9198
COL11A1	9248
ITGB2	9461
ITGA2B	9472
TMPRSS6	9473
ITGA10	9514
EFEMP2	9651
COLGALT1	10239
LAMA3	10497
CTSS	10734
CAPN11	10735
MMP3	10821
ICAM3	10918
PRSS1	11133
DDR1	11240
COL8A2	11344
P4HB	11751

---

REACTOME_SARS_COV_2_HOST_INTERACTIONS

REACTOME_SARS_COV_2_HOST_INTERACTIONS

	1571
set	REACTOME_SARS_COV_2_HOST_INTERACTIONS
setSize	191
pANOVA	0.000415
s.dist	0.148
p.adjustANOVA	0.0171

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAB1	11522
CRB3	11436
IFNA1	11270
ISG15	10963
VPS33B	10926
NUP37	10891
IRF7	10885
HLA-F	10704
RPS24	10632
IFNA13	10532
SNRPD2	10271
TUFM	10261
IKBKB	10186
UBA52	10169
SNRPF	10159
VPS39	10128
NUP85	10105
PDPK1	10091
DDX20	9996
HLA-E	9228

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAB1	11522.0
CRB3	11436.0
IFNA1	11270.0
ISG15	10963.0
VPS33B	10926.0
NUP37	10891.0
IRF7	10885.0
HLA-F	10704.0
RPS24	10632.0
IFNA13	10532.0
SNRPD2	10271.0
TUFM	10261.0
IKBKB	10186.0
UBA52	10169.0
SNRPF	10159.0
VPS39	10128.0
NUP85	10105.0
PDPK1	10091.0
DDX20	9996.0
HLA-E	9228.0
STAT2	9208.0
GEMIN4	9188.0
IFNA16	9121.0
IFNA8	8989.0
SEH1L	8981.0
RIGI	8912.0
YWHAB	8801.0
ATG14	8600.0
B2M	8560.0
CREBBP	8505.0
IFNAR1	8400.0
PIK3R4	8377.0
RPS14	8357.0
NUP88	8287.0
RPS20	8266.0
NUP42	8255.0
YWHAZ	8195.0
RPS27	8146.0
FAU	8073.0
RPS5	8053.0
SMN1	8042.5
SMN2	8042.5
SAR1B	7795.0
NUP62	7784.0
PTPN6	7678.0
TPR	7435.0
STAT1	7294.0
RANBP2	7289.0
MAVS	7199.0
IFIH1	7159.0
IFNA6	7135.0
CNBP	7083.0
SNRPD1	7057.0
NUP93	6988.0
RPS15	6917.0
RPS7	6908.0
NUP214	6722.0
PALS1	6697.0
AKT1	6607.0
G3BP1	6534.0
RPS18	6474.0
RAE1	6386.0
UBB	6377.0
NUP153	6267.0
NUP188	6088.0
VPS11	6041.0
HLA-B	6020.0
UBE2V1	6001.0
AKT2	5870.0
NUP54	5830.0
MAP1LC3B	5812.0
RIPK2	5736.0
SEC23A	5642.0
PTPN11	5640.0
RPS6	5583.0
VPS33A	5529.0
VPS41	5508.0
NUP133	5499.0
SEC24A	5482.0
IRF3	5278.0
SIKE1	5076.0
MASP2	5017.0
NUP58	4880.0
AAAS	4718.0
LARP1	4613.0
NUP107	4332.0
MASP1	4288.0
NDC1	4258.0
TRAF3	4183.0
CHUK	4148.0
TOMM70	3776.0
CAV1	3760.0
SNRPD3	3720.0
RPS23	3706.0
RPS13	3696.0
RPS11	3544.0
TBK1	3387.0
PATJ	3257.0
SEC24C	3133.0
TRIM25	3005.0
UVRAG	2780.0
NUP43	2770.0
IFNB1	2681.0
NUP98	2445.0
RPS21	2412.0
PIK3C3	2277.0
G3BP2	2271.0
GEMIN2	2137.0
HSP90AB1	2115.0
RPS2	2069.0
NUP160	2051.0
YWHAH	1632.0
RPS3	1291.0
KPNA2	1259.0
HLA-C	1212.0
YWHAQ	1114.0
TAB2	1079.0
NLRP12	976.0
RPS27L	566.0
TYK2	306.0
RPS9	183.0
RPS10	102.0
RPS3A	-233.0
RPS26	-319.0
SNRPB	-401.0
TRAF6	-626.0
HLA-G	-673.0
NUP35	-710.0
RPS19	-748.0
IFNAR2	-751.0
HLA-A	-902.0
RPS25	-928.0
SNRPG	-949.0
RPS15A	-1190.0
TLR2	-1307.0
YWHAG	-1477.0
MAP3K7	-1507.0
AKT3	-1580.0
RPS28	-1593.0
SEC13	-1604.0
RPS29	-1802.0
TLR1	-1972.0
JAK1	-2142.0
GEMIN6	-2249.0
GEMIN7	-2369.0
RPS16	-2419.0
RPS27A	-2472.0
IL17RC	-2527.0
NLRP3	-2898.0
NUP205	-3003.0
SEC24D	-3129.0
BECN1	-3180.0
YWHAE	-3214.0
HSP90AA1	-3286.0
GEMIN5	-3494.0
NUP50	-3509.0
NUP210	-3669.0
IFNA5	-3827.0
SEC24B	-3858.0
POM121	-3922.0
TJP1	-4334.0
IFNA14	-4373.0
GJA1	-4611.0
SFN	-4660.0
VPS18	-4731.0
RPS8	-5241.0
IL17RA	-5414.0
RPSA	-5754.0
TRIM4	-5899.0
NUP155	-5949.0
IL17A	-6179.0
IRAK2	-6294.0
UBE2N	-6780.0
UBC	-6842.0
VPS16	-6919.0
VPS45	-6974.0
IFNA21	-7128.0
SNRPE	-7134.0
IKBKE	-7451.0
NOD1	-7516.0
RNF135	-7633.0
TKFC	-8012.0
RPS12	-8043.0
POM121C	-8073.0
IL17F	-9252.0
SFTPD	-9589.0
IFNA7	-9606.0
NOD2	-9647.0
STING1	-9782.0
MBL2	-9921.0
IFNA2	-10019.0

---

REACTOME_SEPARATION_OF_SISTER_CHROMATIDS

REACTOME_SEPARATION_OF_SISTER_CHROMATIDS

	492
set	REACTOME_SEPARATION_OF_SISTER_CHROMATIDS
setSize	184
pANOVA	0.000445
s.dist	0.15
p.adjustANOVA	0.0178

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
PSMD3	11142
NUP37	10891
NSL1	10890
PPP2R5D	10754
RCC2	10660
PSMC1	10399
PSMB1	10173
UBA52	10169
B9D2	10123
NUP85	10105
PSMC6	9892
ZW10	9885
CDC23	9833
XPO1	9708
BUB1B	9436

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TUBB8	11383
TUBB1	11311
DYNLL2	11280
MAPRE1	11267
DYNC1LI2	11173
PSMD3	11142
NUP37	10891
NSL1	10890
PPP2R5D	10754
RCC2	10660
PSMC1	10399
PSMB1	10173
UBA52	10169
B9D2	10123
NUP85	10105
PSMC6	9892
ZW10	9885
CDC23	9833
XPO1	9708
BUB1B	9436
PPP2R5A	9306
PSMD4	9234
SEH1L	8981
PSME3	8732
CENPF	8713
BIRC5	8644
TUBA1B	8427
ANAPC10	8406
PSMD13	8389
KIF2A	8369
RPS27	8146
ZWILCH	7966
PSMC3	7956
PSMA3	7703
DYNC1H1	7672
CENPC	7578
KNL1	7549
TAOK1	7414
PSMD7	7334
RANBP2	7289
PDS5A	7273
PSMA7	6898
PSMA1	6861
PSMB2	6549
PSMC4	6484
KIF2C	6395
UBB	6377
CDC16	6332
CENPO	6310
PSMD9	6250
TUBB4B	6227
KIF18A	6129
TUBB2B	6024
PPP2R5B	6021
CENPK	6007
ITGB3BP	5989
PSMD14	5956
PSMA6	5773
RANGAP1	5723
CDCA5	5505
NUP133	5499
TUBA1A	5468
PSME2	5380
PSMD11	5320
UBE2S	5276
CDC26	5157
ANAPC1	5092
PSMB5	5052
PSMB3	4835
PPP2R1B	4800
CENPP	4572
AURKB	4455
DYNC1LI1	4367
NUF2	4365
NUP107	4332
NDEL1	4296
PMF1	4252
PSME4	4171
MAD1L1	4118
PPP2R5C	4099
PSMD12	3928
ANAPC7	3809
TUBB3	3788
CENPU	3739
PSMD5	3711
PSMB8	3681
PSMA4	3640
MIS12	3486
ANAPC5	3355
ANAPC4	3312
INCENP	3298
MAD2L1	3280
BUB3	3260
STAG1	3161
PSMD1	3063
RAD21	2837
NUP43	2770
CKAP5	2726
CDC27	2701
SMC3	2481
CLASP1	2462
NUP98	2445
PPP2R5E	2327
PSMB9	2322
PDS5B	2276
NUP160	2051
ZWINT	2046
ANAPC2	1989
NDC80	1973
KNTC1	1764
PLK1	1754
CDCA8	1598
DSN1	1571
PSMC5	1519
TUBA8	1505
BUB1	1430
UBE2D1	1355
PPP2CA	1345
PAFAH1B1	1262
WAPL	929
PPP2R1A	849
DYNC1I2	583
SGO2	363
TUBB6	295
CENPT	266
CENPL	253
PSMF1	4
SEM1	-434
PSMC2	-844
CDC20	-1019
SGO1	-1205
CENPN	-1337
CLASP2	-1411
CENPQ	-1502
SEC13	-1604
NUDC	-1933
PTTG1	-2073
PSMD6	-2201
PSMD8	-2294
TUBA4A	-2325
TUBA4B	-2380
ESPL1	-2406
RPS27A	-2472
ANAPC11	-2624
SKA1	-2643
PSMA2	-2726
CLIP1	-2732
AHCTF1	-2954
CENPM	-3005
PSMB4	-3191
PPP1CC	-3357
PSMA8	-3478
CENPS	-3513
SKA2	-3548
NDE1	-3667
PSMB10	-3966
TUBA1C	-3972
ANAPC16	-4002
ANAPC15	-4142
PSMA5	-4274
PSMB6	-4786
DYNLL1	-4954
SPC25	-5044
CENPA	-5151
PSMB7	-5258
DYNC1I1	-5309
UBE2C	-5371
CENPH	-5646
TUBA3D	-6078
PPP2CB	-6157
PSMD2	-6176
SPC24	-6708
UBC	-6842
TUBB4A	-7113
CENPE	-7223
UBE2E1	-7595
TUBA3C	-7603
PSME1	-7763
TUBB2A	-8021
PSMB11	-8541
TUBA3E	-8723
SPDL1	-8769
TUBAL3	-9053
KIF2B	-9529

---

REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

	1004
set	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES
setSize	187
pANOVA	0.00049
s.dist	0.148
p.adjustANOVA	0.019

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAB1	11522
DDB2	11268
H2AC14	11207
PSMD3	11142
H2BC3	10676
TADA2B	10501
USP2	10472
USP44	10450
PSMC1	10399
USP33	10378
USP8	10243
PSMB1	10173
UBA52	10169
ADRB2	10166
USP22	10127
PSMC6	9892
SMURF2	9848
SMAD2	9684
FKBP8	9642
ADRM1	9610

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAB1	11522.0
DDB2	11268.0
H2AC14	11207.0
PSMD3	11142.0
H2BC3	10676.0
TADA2B	10501.0
USP2	10472.0
USP44	10450.0
PSMC1	10399.0
USP33	10378.0
USP8	10243.0
PSMB1	10173.0
UBA52	10169.0
ADRB2	10166.0
USP22	10127.0
PSMC6	9892.0
SMURF2	9848.0
SMAD2	9684.0
FKBP8	9642.0
ADRM1	9610.0
TGFBR1	9558.0
TP53	9551.0
H2BC14	9533.0
PSMD4	9234.0
VDAC2	9021.0
RIGI	8912.0
PSME3	8732.0
H2AC16	8457.0
H2AC8	8407.0
PSMD13	8389.0
TOMM20	8125.0
POLB	8057.0
RNF123	7984.0
PSMC3	7956.0
UFD1	7888.0
TADA3	7721.0
PSMA3	7703.0
IDE	7653.0
H2BC10	7509.0
CCP110	7454.0
PSMD7	7334.0
H2AC17	7258.0
IFIH1	7159.0
USP7	7118.0
WDR20	7074.0
PSMA7	6898.0
PSMA1	6861.0
OTUB1	6847.0
USP12	6750.0
PSMB2	6549.0
PSMC4	6484.0
BIRC2	6410.0
UBB	6377.0
IL33	6335.0
PSMD9	6250.0
SKP2	6108.0
USP15	6004.0
PSMD14	5956.0
MYC	5940.0
SMAD7	5937.0
H2AC11	5849.0
VDAC3	5792.0
PSMA6	5773.0
HIF1A	5570.0
PSME2	5380.0
PSMD11	5320.0
SMAD4	5313.0
H2AC18	5121.5
H2AC19	5121.5
H2BC8	5070.0
PSMB5	5052.0
H2AC15	4918.0
PSMB3	4835.0
VDAC1	4793.0
USP47	4689.0
USP42	4623.0
MAT2B	4530.0
KAT2A	4523.0
USP14	4377.0
PSME4	4171.0
USP24	4149.0
MDM2	4051.0
H2BC11	4044.0
CLSPN	4002.0
PSMD12	3928.0
ARRB2	3835.0
TOMM70	3776.0
PSMD5	3711.0
PSMB8	3681.0
PSMA4	3640.0
HGS	3373.0
TRAF2	3169.0
RIPK1	3149.0
USP16	3126.0
ARRB1	3085.0
PSMD1	3063.0
USP20	2996.0
TNKS	2784.0
RCE1	2749.0
AXIN2	2631.0
PSMB9	2322.0
CCNA2	1874.0
USP25	1833.0
MDM4	1716.0
PTEN	1587.0
PSMC5	1519.0
H2AC6	1509.0
USP30	1266.0
RHOT1	1244.0
TRRAP	1239.0
AXIN1	936.0
ATXN7	886.0
RNF146	589.0
USP3	399.0
MUL1	313.0
CDC25A	220.0
USP37	85.0
PSMF1	4.0
TAF10	-28.0
USP49	-114.0
H2BC1	-192.0
H2BC4	-260.0
USP5	-289.0
PTRH2	-293.0
H2BC5	-354.0
SIAH2	-371.0
SEM1	-434.0
TRAF6	-626.0
PSMC2	-844.0
KEAP1	-855.0
STAM2	-857.0
NFKBIA	-865.0
SNX3	-957.0
CDC20	-1019.0
TNKS2	-1105.0
H2AC21	-1139.0
USP19	-1244.0
SUDS3	-1326.0
USP28	-1488.0
MAP3K7	-1507.0
WDR48	-1608.0
H2BC12	-1772.0
H2BC17	-2040.0
USP13	-2080.0
H2BC21	-2129.0
PSMD6	-2201.0
PSMD8	-2294.0
USP34	-2403.0
USP48	-2423.0
RPS27A	-2472.0
H2AC1	-2599.0
USP10	-2725.0
PSMA2	-2726.0
H2BC6	-3080.0
H2BC15	-3142.0
BECN1	-3180.0
PSMB4	-3191.0
H2AC20	-3235.0
CFTR	-3432.0
PSMA8	-3478.0
H2BC9	-3718.5
CYLD	-3921.0
PSMB10	-3966.0
H2BC26	-4236.0
PSMA5	-4274.0
USP4	-4331.0
H2AC25	-4404.0
CCNA1	-4580.0
PSMB6	-4786.0
USP21	-5187.0
PSMB7	-5258.0
PSMD2	-6176.0
USP18	-6354.0
RUVBL1	-6422.0
SMAD1	-6789.0
UBC	-6842.0
GATA3	-7751.0
PSME1	-7763.0
H2AC4	-8140.0
PSMB11	-8541.0
SMAD3	-8542.0
H2AC12	-8592.0
BIRC3	-8670.0
H2AC7	-8707.5
H2BC7	-8707.5
H2AC13	-9179.0
H2BC13	-9329.0

---

REACTOME_DNA_REPAIR

REACTOME_DNA_REPAIR

	1168
set	REACTOME_DNA_REPAIR
setSize	321
pANOVA	0.000498
s.dist	0.113
p.adjustANOVA	0.019

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DDB2	11268
H2AC14	11207
AQR	10996
ISG15	10963
TCEA1	10805
H2BC3	10676
PIAS4	10486
EME1	10436
MUS81	10392
UBE2I	10324
BAZ1B	10263
TFPT	10255
PCNA	10230
DCLRE1C	10199
POLR2E	10170
UBA52	10169
FANCF	10155
ATR	10067
APBB1	10049
GTF2H5	10024

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DDB2	11268.0
H2AC14	11207.0
AQR	10996.0
ISG15	10963.0
TCEA1	10805.0
H2BC3	10676.0
PIAS4	10486.0
EME1	10436.0
MUS81	10392.0
UBE2I	10324.0
BAZ1B	10263.0
TFPT	10255.0
PCNA	10230.0
DCLRE1C	10199.0
POLR2E	10170.0
UBA52	10169.0
FANCF	10155.0
ATR	10067.0
APBB1	10049.0
GTF2H5	10024.0
REV3L	9729.0
ADPRS	9662.0
TP53	9551.0
ISY1	9535.0
H2BC14	9533.0
RMI1	9316.0
POLN	9290.0
H4C16	9262.0
H4C11	9253.0
KDM4A	9224.0
RPA3	9109.0
RAD9B	9100.0
FAAP100	9092.0
NPLOC4	9066.0
H4C8	9007.0
RNF168	8997.0
POT1	8988.0
FEN1	8951.0
POLE	8919.0
DNA2	8886.0
GTF2H1	8877.0
USP45	8866.0
ACTB	8836.0
TERF1	8790.0
H2AZ1	8737.0
ERCC5	8707.0
PMS2	8648.0
RAD9A	8617.0
POLR2D	8613.0
BABAM1	8594.0
GTF2H3	8555.0
POLD1	8554.0
ZNF830	8437.0
SUMO2	8422.0
H2AC8	8407.0
KDM4B	8392.0
POLI	8256.0
CUL4A	8254.0
RPA1	8165.0
RTEL1	8103.0
POLB	8057.0
LIG4	7969.0
UFD1	7888.0
HMGN1	7839.0
TDG	7808.0
WRN	7786.0
H4C5	7742.0
UBE2T	7607.0
PPP4R2	7541.0
REV1	7529.0
TDP2	7510.0
H2BC10	7509.0
RAD50	7503.0
CHEK1	7457.0
FAN1	7349.0
XRCC1	7338.0
XRCC5	7254.0
PARP1	7236.0
TERF2IP	7210.0
SUMO3	7150.0
USP7	7118.0
FANCD2	7092.0
COPS4	6956.0
ACTL6A	6941.0
ACTR8	6934.0
H4C3	6897.0
TOP3A	6789.0
INO80E	6749.0
PPIE	6595.0
ATM	6477.0
UBB	6377.0
PNKP	6225.0
PALB2	6043.0
SMARCA5	6005.0
NHEJ1	5952.0
XRCC3	5805.0
RBX1	5779.0
H4C9	5774.0
EP300	5668.0
LIG3	5475.0
VCP	5453.0
ASCC2	5448.0
APEX1	5390.0
MCRS1	5265.0
POLR2I	5240.0
CHEK2	5205.0
ASCC1	5156.0
H2AC18	5121.5
H2AC19	5121.5
RFC2	5115.0
H2BC8	5070.0
FANCM	5050.0
POLR2A	5042.0
USP43	5028.0
NSD2	4961.0
PARP2	4913.0
RCHY1	4826.0
PAXIP1	4778.0
MSH3	4655.0
FANCI	4548.0
RPA2	4484.0
RNF4	4464.0
NFRKB	4427.0
COPS6	4422.0
ERCC6	4285.0
INO80D	4272.0
POLM	4203.0
PRKDC	4181.0
PPP4C	4155.0
POLR2F	4146.0
H2BC11	4044.0
CLSPN	4002.0
TIMELESS	3947.0
XRCC6	3920.0
TOPBP1	3907.0
UBE2B	3873.0
RAD17	3845.0
POLR2H	3756.0
COPS2	3612.0
NBN	3589.0
TDP1	3585.0
RFC4	3563.0
MDC1	3549.0
UIMC1	3376.0
CDK7	3307.0
PIAS1	3286.0
FANCG	3277.0
RIF1	3203.0
PPP5C	3158.0
EYA3	3109.0
H2AX	3086.0
RAD52	3071.0
TRIM25	3005.0
XPA	2975.0
SPRTN	2953.0
EME2	2732.0
RFC3	2420.0
FAAP20	2414.0
POLQ	2374.0
ACD	2358.5
FANCA	2294.0
H4C1	2273.0
RFC1	2245.0
MAPK8	2156.0
CCNA2	1874.0
ALKBH2	1872.0
COPS3	1756.0
RMI2	1748.0
MAD2L2	1683.0
UVSSA	1682.0
TINF2	1628.0
H2AC6	1509.0
BRCA1	1471.0
H4C4	1434.0
POLL	1419.0
KPNA2	1259.0
POLE2	1257.0
ALKBH5	1256.0
LIG1	1254.0
RBBP8	1178.0
PCLAF	1093.0
MNAT1	1066.0
GTF2H4	1040.0
UBXN1	1026.0
POLR2B	1016.0
TERF2	954.0
SPIDR	860.0
PARG	821.0
INO80	601.0
POLH	479.0
RAD23B	413.0
DCLRE1A	286.0
BABAM2	234.0
ERCC4	207.0
XRCC4	193.0
ALKBH3	-4.0
RAD51	-172.0
H2BC1	-192.0
H2BC4	-260.0
EXO1	-290.0
BAP1	-345.0
POLR2G	-351.0
H2BC5	-354.0
MRE11	-382.0
RAD1	-410.0
SEM1	-434.0
USP1	-475.0
PIAS3	-565.0
DTL	-613.0
TIPIN	-666.0
GPS1	-685.0
ELL	-755.0
POLR2K	-795.0
DDB1	-806.0
MSH2	-904.0
SIRT6	-942.0
YY1	-1037.0
RNF111	-1255.0
HUS1	-1275.0
POLR2C	-1547.0
ERCC1	-1559.0
ABRAXAS1	-1564.0
WDR48	-1608.0
SUMO1	-1643.0
UNG	-1694.0
H4C12	-1743.0
PRPF19	-1758.0
H2BC12	-1772.0
MBD4	-1902.0
ABL1	-1929.0
BLM	-1963.0
XPC	-1967.0
FTO	-2000.0
H2BC17	-2040.0
NEIL3	-2042.0
H2BC21	-2129.0
BARD1	-2156.0
NEIL2	-2392.0
MLH1	-2409.0
RPS27A	-2472.0
RHNO1	-2686.0
USP10	-2725.0
H4C13	-2741.0
FANCE	-2810.0
ACTR5	-2814.0
OGG1	-2890.0
BRCA2	-2940.0
COPS8	-2997.0
EYA4	-3004.0
TP53BP1	-3024.0
H2BC6	-3080.0
H2BC15	-3142.0
POLD3	-3223.0
H2AC20	-3235.0
H3-4	-3300.0
H2AZ2	-3381.0
CENPS	-3513.0
INO80B	-3583.0
H2BC9	-3718.5
UBE2V2	-3757.0
RAD51D	-3866.0
SMUG1	-3879.0
INO80C	-3882.0
SLX4	-3945.0
XAB2	-3998.0
RNF8	-4058.0
EYA2	-4117.0
RFC5	-4136.0
MUTYH	-4221.0
H2BC26	-4236.0
BRIP1	-4248.0
RAD51B	-4319.0
HERC2	-4445.0
CCNA1	-4580.0
ERCC8	-4624.0
KAT5	-4633.0
UBA7	-4653.0
GEN1	-4735.0
COPS5	-4770.0
ATRIP	-4882.0
RAD51C	-4886.0
RAD51AP1	-4887.0
COPS7B	-4924.0
POLE3	-4968.0
POLK	-5000.0
MGMT	-5102.0
ERCC3	-5361.0
FAAP24	-5407.0
RAD23A	-5485.0
POLD2	-5490.0
ERCC2	-5783.0
FANCL	-5857.0
ASCC3	-5904.0
DCLRE1B	-5954.0
H2AJ	-6028.0
UBE2L6	-6074.0
NTHL1	-6090.0
EYA1	-6159.0
POLD4	-6372.0
RUVBL1	-6422.0
H4C6	-6464.0
CDK2	-6684.0
XRCC2	-6703.0
UBE2N	-6780.0
FANCC	-6835.0
UBC	-6842.0
H4C2	-6995.0
COPS7A	-7190.0
RAD18	-7192.0
NEIL1	-7453.0
CCNH	-7541.0
POLR2L	-7683.0
POLE4	-8070.0
MSH6	-8075.0
H2AC4	-8140.0
CHD1L	-8655.0
H2AC7	-8707.5
H2BC7	-8707.5
MPG	-8950.0
H2BC13	-9329.0
POLR2J	-9382.0

---

REACTOME_NEDDYLATION

REACTOME_NEDDYLATION

	1308
set	REACTOME_NEDDYLATION
setSize	235
pANOVA	0.000565
s.dist	0.131
p.adjustANOVA	0.0211

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ASB10	11362
DDB2	11268
PSMD3	11142
FBXL22	10901
ASB16	10434
PSMC1	10399
KCTD6	10198
UBE2M	10180
PSMB1	10173
BTRC	10171
UBA52	10169
FBXL14	10148
PSMC6	9892
COMMD7	9807
KBTBD6	9793
DCAF16	9780
DCAF10	9756
KLHL21	9661
DDA1	9548
UBA3	9455

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ASB10	11362
DDB2	11268
PSMD3	11142
FBXL22	10901
ASB16	10434
PSMC1	10399
KCTD6	10198
UBE2M	10180
PSMB1	10173
BTRC	10171
UBA52	10169
FBXL14	10148
PSMC6	9892
COMMD7	9807
KBTBD6	9793
DCAF16	9780
DCAF10	9756
KLHL21	9661
DDA1	9548
UBA3	9455
FBXL3	9325
PSMD4	9234
FBXL15	9202
NPLOC4	9066
SPSB3	9039
FBXO44	8757
PSME3	8732
BIRC5	8644
RNF7	8452
PSMD13	8389
FBXL16	8317
KCTD7	8268
CUL4A	8254
UBXN7	8130
RBBP5	8079
FEM1A	7975
CCNF	7968
PSMC3	7956
KBTBD7	7923
UFD1	7888
VHL	7882
FBXO30	7801
PSMA3	7703
GAN	7657
ASB7	7598
FBXO21	7551
FEM1C	7539
DCAF13	7394
PSMD7	7334
LRR1	7332
FBXW7	7200
NEDD8	6981
FBXO6	6972
COPS4	6956
PSMA7	6898
PSMA1	6861
DCAF6	6845
FBXO7	6820
KLHL11	6653
PSMB2	6549
PSMC4	6484
COMMD5	6408
FBXO15	6407
FBXO41	6404
UBB	6377
ASB6	6351
FBXW2	6343
PSMD9	6250
COMMD8	6238
SKP2	6108
PALB2	6043
COMMD10	6013
WDR5	5961
PSMD14	5956
ASB8	5939
RBX1	5779
PSMA6	5773
DCUN1D2	5753
SOCS5	5731
CUL7	5727
FBXW4	5726
KLHL22	5724
FEM1B	5603
DCUN1D5	5578
HIF1A	5570
CCDC8	5568
VCP	5453
PSME2	5380
PSMD11	5320
FBXL4	5136
PSMB5	5052
FBXO2	5041
ELOB	5019
COP1	4959
DCUN1D3	4896
PSMB3	4835
SOCS6	4701
FBXO32	4667
KLHL9	4642
FBXW5	4627
COPS6	4422
SPSB1	4397
PUM2	4392
PSME4	4171
COMMD2	4123
UBE2D3	4033
ELOC	3936
PSMD12	3928
PSMD5	3711
PSMB8	3681
PSMA4	3640
COPS2	3612
WSB1	3370
FBXL20	3335
PSMD1	3063
COMMD6	3028
SOCS2	2900
UBE2D2	2801
FBXW8	2672
PSMB9	2322
KLHL3	2247
ASB14	2176
SPSB2	2174
WDTC1	2168
HIF3A	2118
FBXL8	1967
COPS3	1756
FBXO9	1741
FBXL13	1679
UBE2F	1669
DCAF7	1646
PSMC5	1519
KLHL41	1501
BRCA1	1471
SKP1	1470
NAE1	1413
UBE2D1	1355
DCUN1D4	1214
ASB3	1069
FBXO31	872
FBXL18	842
KLHL2	812
COMMD3	741
BTBD6	681
SPSB4	645
FBXL5	635
MUL1	313
KLHL20	219
WSB2	165
FBXW12	74
FBXL19	44
SENP8	8
PSMF1	4
OBSL1	-39
BTBD1	-380
NEURL2	-392
CUL3	-394
FBXO40	-404
SEM1	-434
LRRC41	-487
DTL	-613
GPS1	-685
ASB13	-732
DDB1	-806
EPAS1	-831
PSMC2	-844
KEAP1	-855
FBXO22	-886
FBXL12	-1121
NFE2L2	-1323
ASB1	-1365
DCAF17	-1537
TULP4	-1850
DPP3	-1853
SQSTM1	-1966
PSMD6	-2201
CDKN1A	-2242
FBXW11	-2247
PSMD8	-2294
RPS27A	-2472
CUL2	-2524
DCAF8	-2582
FBXO11	-2639
PSMA2	-2726
FBXO17	-2873
FBXW9	-2921
KLHL25	-2989
KBTBD8	-2991
COPS8	-2997
NUB1	-3082
PSMB4	-3191
ASB4	-3303
PSMA8	-3478
LMO7	-3805
PSMB10	-3966
DCAF11	-4256
PSMA5	-4274
DCAF5	-4471
ERCC8	-4624
COPS5	-4770
PSMB6	-4786
CUL5	-4806
COPS7B	-4924
ZBTB16	-5134
UCHL3	-5172
FBXO27	-5179
ASB17	-5180
COMMD1	-5190
PSMB7	-5258
FBXO4	-5429
CAND1	-5476
KLHL5	-5697
COMMD9	-5911
DCAF4	-6104
PSMD2	-6176
CUL1	-6388
CUL9	-6504
UBD	-6591
CISH	-6648
DCUN1D1	-6665
UBC	-6842
FBXW10	-6910
FBXL7	-6924
ASB15	-6959
ASB18	-6966
COPS7A	-7190
ASB5	-7360
ANKRD9	-7585
KLHL42	-7605
PSME1	-7763
PSMB11	-8541
COMMD4	-8830
SOCS3	-8908
ASB2	-9069
FBXO10	-9381

---

REACTOME_SARS_COV_2_INFECTION

REACTOME_SARS_COV_2_INFECTION

	1553
set	REACTOME_SARS_COV_2_INFECTION
setSize	281
pANOVA	0.000614
s.dist	0.119
p.adjustANOVA	0.0223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TAB1	11522
CRB3	11436
PARP10	11422
IFNA1	11270
ST6GALNAC4	11041
ISG15	10963
VPS33B	10926
NUP37	10891
IRF7	10885
HLA-F	10704
RPS24	10632
IFNA13	10532
ZDHHC8	10428
UBE2I	10324
SNRPD2	10271
TUFM	10261
IKBKB	10186
UBA52	10169
SNRPF	10159
PRKCSH	10158

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TAB1	11522.0
CRB3	11436.0
PARP10	11422.0
IFNA1	11270.0
ST6GALNAC4	11041.0
ISG15	10963.0
VPS33B	10926.0
NUP37	10891.0
IRF7	10885.0
HLA-F	10704.0
RPS24	10632.0
IFNA13	10532.0
ZDHHC8	10428.0
UBE2I	10324.0
SNRPD2	10271.0
TUFM	10261.0
IKBKB	10186.0
UBA52	10169.0
SNRPF	10159.0
PRKCSH	10158.0
VPS39	10128.0
NUP85	10105.0
PDPK1	10091.0
DDX20	9996.0
ANO10	9945.0
DDX5	9484.0
ISCU	9371.0
HLA-E	9228.0
STAT2	9208.0
GEMIN4	9188.0
IFNA16	9121.0
ST6GAL1	9031.0
IFNA8	8989.0
SEH1L	8981.0
RIGI	8912.0
YWHAB	8801.0
ANO8	8798.0
DDOST	8630.0
ATG14	8600.0
B2M	8560.0
CREBBP	8505.0
IFNAR1	8400.0
PIK3R4	8377.0
RPS14	8357.0
GPC2	8334.0
NUP88	8287.0
RPS20	8266.0
NUP42	8255.0
SRPK1	8218.0
YWHAZ	8195.0
CHMP7	8148.0
RPS27	8146.0
FAU	8073.0
RPS5	8053.0
SMN1	8042.5
SMN2	8042.5
PARP9	7970.0
VHL	7882.0
GSK3A	7873.0
CHMP4B	7852.0
SAR1B	7795.0
NUP62	7784.0
PTPN6	7678.0
DAD1	7467.0
TPR	7435.0
STAT1	7294.0
RANBP2	7289.0
MAVS	7199.0
IFIH1	7159.0
IFNA6	7135.0
ST3GAL2	7128.0
ST3GAL1	7090.0
CNBP	7083.0
SNRPD1	7057.0
NUP93	6988.0
ZDHHC5	6937.0
RPS15	6917.0
RPS7	6908.0
NUP214	6722.0
PALS1	6697.0
AKT1	6607.0
G3BP1	6534.0
RPS18	6474.0
RAE1	6386.0
UBB	6377.0
NUP153	6267.0
STT3A	6155.0
NUP188	6088.0
VPS11	6041.0
HLA-B	6020.0
UBE2V1	6001.0
AKT2	5870.0
NUP54	5830.0
MAP1LC3B	5812.0
RIPK2	5736.0
RB1	5689.0
SEC23A	5642.0
PTPN11	5640.0
RPS6	5583.0
CHMP2A	5566.0
VPS33A	5529.0
VPS41	5508.0
NUP133	5499.0
SEC24A	5482.0
VCP	5453.0
IRF3	5278.0
ANO9	5173.0
PARP4	5077.0
SIKE1	5076.0
MASP2	5017.0
MGAT1	4900.0
NUP58	4880.0
AAAS	4718.0
LARP1	4613.0
MGAT5	4389.0
NUP107	4332.0
ANO7	4328.0
MASP1	4288.0
NDC1	4258.0
TRAF3	4183.0
CHUK	4148.0
GSK3B	4021.0
TOMM70	3776.0
CAV1	3760.0
PRMT1	3725.0
SNRPD3	3720.0
RPS23	3706.0
RPS13	3696.0
GOLGA7	3629.0
RPS11	3544.0
CSNK1A1	3493.0
CHMP6	3463.0
TBK1	3387.0
EDEM2	3303.0
PATJ	3257.0
GANAB	3184.0
SEC24C	3133.0
FUT8	3099.0
TRIM25	3005.0
UVRAG	2780.0
NUP43	2770.0
IFNB1	2681.0
GPC1	2591.0
NUP98	2445.0
SDC3	2435.0
RPS21	2412.0
ZCRB1	2379.0
PIK3C3	2277.0
G3BP2	2271.0
GEMIN2	2137.0
HSP90AB1	2115.0
RPS2	2069.0
NUP160	2051.0
SDC4	1931.0
MAN1B1	1853.0
ST3GAL3	1802.0
YWHAH	1632.0
ZDHHC2	1621.0
RPS3	1291.0
KPNA2	1259.0
HLA-C	1212.0
YWHAQ	1114.0
ANO6	1091.0
TAB2	1079.0
MGAT2	1019.5
NLRP12	976.0
RPN1	944.0
ST6GALNAC2	766.0
RPS27L	566.0
TYK2	306.0
SDC2	259.0
RPS9	183.0
CANX	160.0
HAVCR1	142.0
RPS10	102.0
PARP14	-177.0
GPC6	-225.0
RPS3A	-233.0
NRP1	-269.0
RPS26	-319.0
SNRPB	-401.0
MGAT4A	-459.0
TRAF6	-626.0
HLA-G	-673.0
NUP35	-710.0
RPS19	-748.0
IFNAR2	-751.0
HLA-A	-902.0
RPS25	-928.0
SNRPG	-949.0
RPS15A	-1190.0
TLR2	-1307.0
ZDHHC3	-1425.0
YWHAG	-1477.0
MAP3K7	-1507.0
AKT3	-1580.0
RPS28	-1593.0
SEC13	-1604.0
SUMO1	-1643.0
RPS29	-1802.0
TLR1	-1972.0
PARP8	-2021.0
RPN2	-2137.0
JAK1	-2142.0
SRPK2	-2203.0
GEMIN6	-2249.0
GEMIN7	-2369.0
RPS16	-2419.0
MAN2A1	-2420.0
ANO5	-2450.0
RPS27A	-2472.0
IL17RC	-2527.0
ST3GAL4	-2716.0
NLRP3	-2898.0
NUP205	-3003.0
SEC24D	-3129.0
BECN1	-3180.0
YWHAE	-3214.0
PARP6	-3228.0
HSP90AA1	-3286.0
HSPG2	-3297.0
ST6GALNAC3	-3321.0
GEMIN5	-3494.0
NUP50	-3509.0
ZDHHC20	-3586.0
MGAT4C	-3605.0
NUP210	-3669.0
IFNA5	-3827.0
SEC24B	-3858.0
CHMP3	-3897.0
POM121	-3922.0
GPC5	-4096.0
TJP1	-4334.0
CTSL	-4367.0
IFNA14	-4373.0
SDC1	-4540.0
GJA1	-4611.0
SFN	-4660.0
VPS18	-4731.0
ANO3	-4733.0
ANO1	-4872.0
RPS8	-5241.0
PARP16	-5384.0
IL17RA	-5414.0
CHMP2B	-5574.0
MGAT4B	-5741.0
RPSA	-5754.0
TRIM4	-5899.0
NUP155	-5949.0
CHMP4A	-5994.0
AGRN	-6085.0
IL17A	-6179.0
ZDHHC11	-6205.0
GALNT1	-6215.0
IRAK2	-6294.0
ANO2	-6297.0
UBE2N	-6780.0
UBC	-6842.0
VPS16	-6919.0
VPS45	-6974.0
IFNA21	-7128.0
SNRPE	-7134.0
IKBKE	-7451.0
NOD1	-7516.0
RNF135	-7633.0
TKFC	-8012.0
RPS12	-8043.0
POM121C	-8073.0
ANO4	-8143.0
TMPRSS2	-8173.0
TUSC3	-8180.0
MOGS	-8526.0
FURIN	-8937.0
IL17F	-9252.0
CHMP4C	-9374.0
SFTPD	-9589.0
IFNA7	-9606.0
NOD2	-9647.0
STING1	-9782.0
MBL2	-9921.0
IFNA2	-10019.0

---

REACTOME_PROTEIN_LOCALIZATION

REACTOME_PROTEIN_LOCALIZATION

	1461
set	REACTOME_PROTEIN_LOCALIZATION
setSize	153
pANOVA	0.000626
s.dist	0.16
p.adjustANOVA	0.0223

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GSTK1	11450
SLC27A2	11293
PIPOX	11262
ATAD1	11107
ACOT4	11086
TIMM50	10785
TOMM40	10593
GET3	10543
GET4	10420
TIMM22	10264
UBA52	10169
SAMM50	9837
MPV17	9527
HSCB	9456
PEX11B	9435
VAMP2	9416
PEX16	9392
SERP1	9268
COX17	8876
SEC61G	8671

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GSTK1	11450
SLC27A2	11293
PIPOX	11262
ATAD1	11107
ACOT4	11086
TIMM50	10785
TOMM40	10593
GET3	10543
GET4	10420
TIMM22	10264
UBA52	10169
SAMM50	9837
MPV17	9527
HSCB	9456
PEX11B	9435
VAMP2	9416
PEX16	9392
SERP1	9268
COX17	8876
SEC61G	8671
CHCHD7	8608
AGPS	8489
TOMM6	8432
PMPCB	8352
TOMM20	8125
PEX26	8101
TOMM5	8021
ALDH3A2	8018
TIMM17A	8016
TYSND1	8000
COA6	7919
IDE	7653
CAMLG	7601
PXMP2	7568
CAT	7524
DECR2	7413
GFER	7369
ABCD2	7151
MTX2	7103
PXMP4	6954
DHRS4	6684
IDH1	6625
PEX12	6471
UBB	6377
ECH1	6376
TIMM10B	6067
GNPAT	6061
TIMM13	5949
ACO2	5616
HSPA9	5350
PEX14	4973
VDAC1	4793
PEX10	4750
TOMM22	4746
ATP5F1A	4744
SEC61B	4500
PEX2	4402
PEX3	4387
CYC1	4335
ABCD3	4294
UBE2D3	4033
ZFAND6	3994
BCS1L	3985
LONP2	3944
TOMM70	3776
TIMM23	3765
CYB5A	3560
AMACR	3504
BAAT	3397
PMPCA	3290
SGTA	3267
HMOX1	3178
COA4	3147
HAO2	3135
PEX7	2890
PEX6	2842
UBE2D2	2801
GRPEL2	2736
PEX1	2622
ACOX3	2615
ACOT8	2610
HSPD1	2554
PEX5	2404
SCP2	2345
ACOT2	2253
VAPA	2173
SLC25A12	2129
ACBD5	1855
SLC25A17	1828
TIMM21	1804
FXN	1703
BAG6	1699
FIS1	1592
NUDT19	1477
APP	1473
UBE2D1	1355
ACAA1	1231
NUDT7	1184
SLC25A13	1155
GET1	1122
CHCHD5	957
DNAJC19	907
GRPEL1	833
GDAP1	739
MLYCD	731
EHHADH	700
TIMM44	379
PEX13	54
CROT	-50
TIMM9	-107
CS	-133
ACOX1	-358
PRNP	-374
HSD17B4	-523
ECI2	-756
TIMM8B	-989
SLC25A4	-1021
COX19	-1493
DDO	-1656
COQ2	-1783
CMC2	-2204
UBE2J2	-2266
ATP5MC1	-2318
OTOF	-2353
RPS27A	-2472
TOMM7	-2637
CHCHD2	-3067
PAOX	-3316
HMGCL	-4172
PECR	-4183
LDHD	-4461
ATP5F1B	-4655
STX5	-4820
PHYH	-4928
PITRM1	-4953
CHCHD4	-5077
HACL1	-5262
EPHX2	-5271
HAO1	-5331
CRAT	-5498
STX1A	-5888
CHCHD3	-5959
NOS2	-5986
PEX19	-6060
MTX1	-6149
CHCHD10	-6241
UBC	-6842
DAO	-7231
ACOX2	-7780
NDUFB8	-8523
PAM16	-8852
TIMM10	-9172
AGXT	-9744

---

REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

	1298
set	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION
setSize	59
pANOVA	0.00073
s.dist	0.254
p.adjustANOVA	0.0255

Top enriched genes

Top 20 genes

GeneID	Gene Rank
HDAC5	11105
MTA3	10531
SNAI2	10258
JUN	9721
LAMTOR4	9628
TP53	9551
NR2E1	9525
SNAI1	9520
ATN1	9128
GATAD2B	8932
HDAC3	8661
CHD3	8412
RRAGA	8261
CHD4	8242
REST	8214
RRAGD	7937
HDAC1	7688
MAF1	7508
RNF2	7121
HDAC2	6444

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
HDAC5	11105
MTA3	10531
SNAI2	10258
JUN	9721
LAMTOR4	9628
TP53	9551
NR2E1	9525
SNAI1	9520
ATN1	9128
GATAD2B	8932
HDAC3	8661
CHD3	8412
RRAGA	8261
CHD4	8242
REST	8214
RRAGD	7937
HDAC1	7688
MAF1	7508
RNF2	7121
HDAC2	6444
LAMTOR5	6246
EGR1	6207
CBX8	6182
GATAD2A	5722
ATF2	5532
CBX4	5225
EED	5078
SALL4	5044
SCMH1	4833
MTA1	4534
RRAGC	4408
RHEB	4311
SLC38A9	3942
RBBP4	3906
MBD3	3615
LAMTOR3	3112
LAMTOR2	2942
RPTOR	2905
MAPK3	2077
MECOM	1613
PTEN	1587
BMI1	1490
MTOR	1229
KDM1A	1089
MAPK1	915
SUZ12	349
EZH2	-344
MLST8	-2078
PHC3	-2479
RING1	-3272
MTA2	-3732
PPARG	-3832
LAMTOR1	-4126
PHC2	-4460
RCOR1	-5587
HDAC7	-5767
CBX6	-5952
CBX2	-7506
PHC1	-9004

---

REACTOME_G2_M_CHECKPOINTS

REACTOME_G2_M_CHECKPOINTS

	1116
set	REACTOME_G2_M_CHECKPOINTS
setSize	162
pANOVA	0.000815
s.dist	0.152
p.adjustANOVA	0.0279

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PSMD3	11142
H2BC3	10676
PIAS4	10486
PSMC1	10399
CCNB2	10190
PSMB1	10173
UBA52	10169
ATR	10067
PSMC6	9892
ORC1	9866
ORC6	9596
TP53	9551
H2BC14	9533
CCNB1	9488
RMI1	9316
H4C16	9262
H4C11	9253
PSMD4	9234
RPA3	9109
RAD9B	9100

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PSMD3	11142.0
H2BC3	10676.0
PIAS4	10486.0
PSMC1	10399.0
CCNB2	10190.0
PSMB1	10173.0
UBA52	10169.0
ATR	10067.0
PSMC6	9892.0
ORC1	9866.0
ORC6	9596.0
TP53	9551.0
H2BC14	9533.0
CCNB1	9488.0
RMI1	9316.0
H4C16	9262.0
H4C11	9253.0
PSMD4	9234.0
RPA3	9109.0
RAD9B	9100.0
H4C8	9007.0
RNF168	8997.0
DNA2	8886.0
YWHAB	8801.0
PSME3	8732.0
RAD9A	8617.0
BABAM1	8594.0
PSMD13	8389.0
YWHAZ	8195.0
RPA1	8165.0
PSMC3	7956.0
WRN	7786.0
H4C5	7742.0
PSMA3	7703.0
H2BC10	7509.0
RAD50	7503.0
CHEK1	7457.0
PSMD7	7334.0
MCM5	7141.0
PSMA7	6898.0
H4C3	6897.0
PSMA1	6861.0
TOP3A	6789.0
CDC25C	6560.0
PSMB2	6549.0
PSMC4	6484.0
ATM	6477.0
UBB	6377.0
MCM7	6360.0
CDK1	6313.0
PSMD9	6250.0
PSMD14	5956.0
H4C9	5774.0
PSMA6	5773.0
PKMYT1	5593.0
MCM8	5436.0
PSME2	5380.0
PSMD11	5320.0
CHEK2	5205.0
RFC2	5115.0
H2BC8	5070.0
PSMB5	5052.0
NSD2	4961.0
PSMB3	4835.0
RPA2	4484.0
ORC4	4299.0
PSME4	4171.0
H2BC11	4044.0
CLSPN	4002.0
PSMD12	3928.0
TOPBP1	3907.0
RAD17	3845.0
PSMD5	3711.0
PSMB8	3681.0
PSMA4	3640.0
ORC2	3590.0
NBN	3589.0
RFC4	3563.0
MDC1	3549.0
UIMC1	3376.0
MCM3	3239.0
H2AX	3086.0
PSMD1	3063.0
ORC5	2938.0
WEE1	2466.0
RFC3	2420.0
PSMB9	2322.0
H4C1	2273.0
DBF4	1954.0
RMI2	1748.0
GTSE1	1709.0
YWHAH	1632.0
PSMC5	1519.0
CDC6	1513.0
BRCA1	1471.0
H4C4	1434.0
CDC45	1297.0
RBBP8	1178.0
YWHAQ	1114.0
ORC3	791.0
CDC7	394.0
MCM2	327.0
BABAM2	234.0
CDC25A	220.0
PSMF1	4.0
H2BC1	-192.0
H2BC4	-260.0
EXO1	-290.0
H2BC5	-354.0
MRE11	-382.0
RAD1	-410.0
SEM1	-434.0
PSMC2	-844.0
HUS1	-1275.0
YWHAG	-1477.0
ABRAXAS1	-1564.0
H4C12	-1743.0
MCM4	-1749.0
H2BC12	-1772.0
BLM	-1963.0
H2BC17	-2040.0
H2BC21	-2129.0
MCM10	-2132.0
BARD1	-2156.0
PSMD6	-2201.0
PSMD8	-2294.0
RPS27A	-2472.0
RHNO1	-2686.0
PSMA2	-2726.0
H4C13	-2741.0
TP53BP1	-3024.0
H2BC6	-3080.0
H2BC15	-3142.0
PSMB4	-3191.0
YWHAE	-3214.0
H3-4	-3300.0
PSMA8	-3478.0
H2BC9	-3718.5
UBE2V2	-3757.0
PSMB10	-3966.0
RNF8	-4058.0
RFC5	-4136.0
H2BC26	-4236.0
MCM6	-4245.0
BRIP1	-4248.0
PSMA5	-4274.0
HERC2	-4445.0
KAT5	-4633.0
SFN	-4660.0
PSMB6	-4786.0
ATRIP	-4882.0
PSMB7	-5258.0
PSMD2	-6176.0
H4C6	-6464.0
CDK2	-6684.0
UBE2N	-6780.0
UBC	-6842.0
H4C2	-6995.0
PSME1	-7763.0
PSMB11	-8541.0
H2BC7	-8707.5
H2BC13	-9329.0

---

REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

	635
set	REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY
setSize	64
pANOVA	0.000873
s.dist	0.241
p.adjustANOVA	0.0292

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CD3D	11806
CTLA4	11744
CD3G	11740
LCK	11679
BTLA	11502
GRAP2	11494
PDCD1	11469
CD3E	11468
CD247	11377
HLA-DQA1	11196
VAV1	11098
PPP2R5D	10754
CSK	10710
PDPK1	10091
PPP2R5A	9306
CD28	7686
PTPN6	7678
CDC42	7131
AKT1	6607
SRC	6197

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CD3D	11806
CTLA4	11744
CD3G	11740
LCK	11679
BTLA	11502
GRAP2	11494
PDCD1	11469
CD3E	11468
CD247	11377
HLA-DQA1	11196
VAV1	11098
PPP2R5D	10754
CSK	10710
PDPK1	10091
PPP2R5A	9306
CD28	7686
PTPN6	7678
CDC42	7131
AKT1	6607
SRC	6197
THEM4	6166
HLA-DPA1	6073
PPP2R5B	6021
AKT2	5870
PAK2	5671
PTPN11	5640
HLA-DRB1	5087
PPP2R1B	4800
PAK1	4761
HLA-DRA	4610
PIK3CA	4175
PPP2R5C	4099
CD274	3380
PIK3R3	3043
HLA-DRB5	2685
RICTOR	2329
PPP2R5E	2327
PDCD1LG2	2185
MAPKAP1	2024
PPP2CA	1345
MTOR	1229
PPP2R1A	849
HLA-DPB1	768
PIK3R2	686
TRIB3	187
MAP3K8	-54
MAP3K14	-62
HLA-DQB1	-1110
PRR5	-1177
GRB2	-1330
AKT3	-1580
MLST8	-2078
LYN	-2322
YES1	-2333
CD80	-2384
PIK3R1	-2742
RAC1	-2752
FYN	-5782
HLA-DQB2	-5823
HLA-DQA2	-5890
PPP2CB	-6157
CD86	-7049
CD4	-8069
ICOS	-9358

---

REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

	842
set	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS
setSize	38
pANOVA	0.000897
s.dist	-0.311
p.adjustANOVA	0.0294

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ADAMTS16	-8974
ADAMTSL1	-8077
ADAMTS9	-7672
THBS1	-7436
ADAMTS2	-7149
THSD1	-6782
ADAMTS14	-6721
THSD7B	-6455
ADAMTS1	-6344
ADAMTS19	-6311
ADAMTS15	-6221
SEMA5A	-6127
THSD7A	-5903
ADAMTS17	-5768
ADAMTSL2	-5731
ADAMTS10	-5316
ADAMTS18	-4814
SPON1	-4670
ADAMTSL3	-4604
ADAMTS7	-3441

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ADAMTS16	-8974
ADAMTSL1	-8077
ADAMTS9	-7672
THBS1	-7436
ADAMTS2	-7149
THSD1	-6782
ADAMTS14	-6721
THSD7B	-6455
ADAMTS1	-6344
ADAMTS19	-6311
ADAMTS15	-6221
SEMA5A	-6127
THSD7A	-5903
ADAMTS17	-5768
ADAMTSL2	-5731
ADAMTS10	-5316
ADAMTS18	-4814
SPON1	-4670
ADAMTSL3	-4604
ADAMTS7	-3441
SPON2	-3361
SSPOP	-2924
THSD4	-2087
SEMA5B	-1582
ADAMTS3	-1387
ADAMTS6	-1374
ADAMTS13	-1264
THBS2	-1099
ADAMTS20	-825
ADAMTS12	-262
ADAMTS8	1145
SBSPON	2331
ADAMTS4	2533
ADAMTSL5	4584
B3GLCT	6586
ADAMTS5	6796
ADAMTSL4	8348
POFUT2	9161

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.2 (2023-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.3.3                                      
##  [2] GGally_2.2.0                                       
##  [3] ggplot2_3.4.4                                      
##  [4] reshape2_1.4.4                                     
##  [5] gtools_3.9.5                                       
##  [6] tibble_3.2.1                                       
##  [7] dplyr_1.1.4                                        
##  [8] echarts4r_0.4.5                                    
##  [9] png_0.1-8                                          
## [10] gridExtra_2.3                                      
## [11] missMethyl_1.36.0                                  
## [12] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1 
## [13] beeswarm_0.4.0                                     
## [14] kableExtra_1.3.4                                   
## [15] gplots_3.1.3                                       
## [16] mitch_1.15.0                                       
## [17] tictoc_1.2                                         
## [18] HGNChelper_0.8.1                                   
## [19] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [20] IlluminaHumanMethylation450kmanifest_0.4.0         
## [21] minfi_1.48.0                                       
## [22] bumphunter_1.44.0                                  
## [23] locfit_1.5-9.8                                     
## [24] iterators_1.0.14                                   
## [25] foreach_1.5.2                                      
## [26] Biostrings_2.70.1                                  
## [27] XVector_0.42.0                                     
## [28] SummarizedExperiment_1.32.0                        
## [29] Biobase_2.62.0                                     
## [30] MatrixGenerics_1.14.0                              
## [31] matrixStats_1.2.0                                  
## [32] GenomicRanges_1.54.1                               
## [33] GenomeInfoDb_1.38.2                                
## [34] IRanges_2.36.0                                     
## [35] S4Vectors_0.40.2                                   
## [36] BiocGenerics_0.48.1                                
## [37] eulerr_7.0.0                                       
## [38] limma_3.58.1                                       
## 
## loaded via a namespace (and not attached):
##   [1] splines_4.3.2             later_1.3.2              
##   [3] BiocIO_1.12.0             bitops_1.0-7             
##   [5] filelock_1.0.3            preprocessCore_1.64.0    
##   [7] XML_3.99-0.16             lifecycle_1.0.4          
##   [9] lattice_0.22-5            MASS_7.3-60              
##  [11] base64_2.0.1              scrime_1.3.5             
##  [13] magrittr_2.0.3            sass_0.4.8               
##  [15] rmarkdown_2.25            jquerylib_0.1.4          
##  [17] yaml_2.3.8                httpuv_1.6.13            
##  [19] doRNG_1.8.6               askpass_1.2.0            
##  [21] DBI_1.1.3                 RColorBrewer_1.1-3       
##  [23] abind_1.4-5               zlibbioc_1.48.0          
##  [25] rvest_1.0.3               quadprog_1.5-8           
##  [27] purrr_1.0.2               RCurl_1.98-1.13          
##  [29] rappdirs_0.3.3            GenomeInfoDbData_1.2.11  
##  [31] genefilter_1.84.0         annotate_1.80.0          
##  [33] svglite_2.1.3             DelayedMatrixStats_1.24.0
##  [35] codetools_0.2-19          DelayedArray_0.28.0      
##  [37] xml2_1.3.6                tidyselect_1.2.0         
##  [39] beanplot_1.3.1            BiocFileCache_2.10.1     
##  [41] webshot_0.5.5             illuminaio_0.44.0        
##  [43] GenomicAlignments_1.38.0  jsonlite_1.8.8           
##  [45] multtest_2.58.0           ellipsis_0.3.2           
##  [47] survival_3.5-7            systemfonts_1.0.5        
##  [49] tools_4.3.2               progress_1.2.3           
##  [51] Rcpp_1.0.11               glue_1.6.2               
##  [53] SparseArray_1.2.2         xfun_0.41                
##  [55] HDF5Array_1.30.0          withr_2.5.2              
##  [57] fastmap_1.1.1             rhdf5filters_1.14.1      
##  [59] fansi_1.0.6               openssl_2.1.1            
##  [61] caTools_1.18.2            digest_0.6.33            
##  [63] R6_2.5.1                  mime_0.12                
##  [65] colorspace_2.1-0          biomaRt_2.58.0           
##  [67] RSQLite_2.3.4             utf8_1.2.4               
##  [69] tidyr_1.3.0               generics_0.1.3           
##  [71] data.table_1.14.10        rtracklayer_1.62.0       
##  [73] prettyunits_1.2.0         httr_1.4.7               
##  [75] htmlwidgets_1.6.4         S4Arrays_1.2.0           
##  [77] ggstats_0.5.1             pkgconfig_2.0.3          
##  [79] gtable_0.3.4              blob_1.2.4               
##  [81] siggenes_1.76.0           htmltools_0.5.7          
##  [83] scales_1.3.0              rstudioapi_0.15.0        
##  [85] knitr_1.45                tzdb_0.4.0               
##  [87] rjson_0.2.21              nlme_3.1-163             
##  [89] curl_5.2.0                org.Hs.eg.db_3.18.0      
##  [91] cachem_1.0.8              rhdf5_2.46.1             
##  [93] stringr_1.5.1             KernSmooth_2.23-22       
##  [95] AnnotationDbi_1.64.1      restfulr_0.0.15          
##  [97] GEOquery_2.70.0           pillar_1.9.0             
##  [99] grid_4.3.2                reshape_0.8.9            
## [101] vctrs_0.6.5               promises_1.2.1           
## [103] dbplyr_2.4.0              xtable_1.8-4             
## [105] evaluate_0.23             readr_2.1.4              
## [107] GenomicFeatures_1.54.1    cli_3.6.2                
## [109] compiler_4.3.2            Rsamtools_2.18.0         
## [111] rlang_1.1.2               crayon_1.5.2             
## [113] rngtools_1.5.2            nor1mix_1.3-2            
## [115] mclust_6.0.1              plyr_1.8.9               
## [117] stringi_1.8.3             viridisLite_0.4.2        
## [119] BiocParallel_1.36.0       munsell_0.5.0            
## [121] Matrix_1.6-1.1            hms_1.1.3                
## [123] sparseMatrixStats_1.14.0  bit64_4.0.5              
## [125] Rhdf5lib_1.24.1           KEGGREST_1.42.0          
## [127] statmod_1.5.0             shiny_1.8.0              
## [129] highr_0.10                memoise_2.0.1            
## [131] bslib_0.6.1               bit_4.0.5

END of report