Mitch Report

date generated: 2021-10-11

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                     diab       PMX
## 0610006L08Rik -5.5412223 1.7043723
## 0610007P14Rik -0.5043192 0.5154128
## 0610009B22Rik -1.1468556 0.7601283
## 0610009E02Rik -1.0617246 0.7364015
## 0610009L18Rik -3.4134523 2.9613348
## 0610009O20Rik -1.1413048 1.7889029

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	28178
duplicated_genes_present	0
num_profile_genes_in_sets	9011
num_profile_genes_not_in_sets	19167
profile_pearson_correl	-0.74519
profile_spearman_correl	-0.68447

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways_mouse.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2504
num_genesets_excluded	1022
num_genesets_included	1482

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 312

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diab	s.PMX	p.diab	p.PMX
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	85	1.11e-34	1.65e-31	1.010	0.6650	-0.7570	2.47e-26	1.35e-33
Viral-mRNA-Translation	73	2.05e-33	1.52e-30	1.070	0.7010	-0.8020	3.15e-25	1.64e-32
Peptide-chain-elongation	73	1.36e-32	6.71e-30	1.050	0.6990	-0.7890	4.63e-25	1.69e-31
Formation-of-a-pool-of-free-40S-subunits	85	2.20e-32	8.16e-30	0.976	0.6530	-0.7250	2.00e-25	5.44e-31
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit	96	2.23e-31	6.62e-29	0.895	0.5780	-0.6840	1.14e-22	3.98e-31
Eukaryotic-Translation-Elongation	77	2.80e-31	6.91e-29	1.000	0.6650	-0.7530	5.05e-24	2.61e-30
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression	95	4.56e-30	9.66e-28	0.883	0.5740	-0.6710	3.79e-22	1.08e-29
Cellular-response-to-starvation	138	2.09e-29	3.87e-27	0.734	0.5170	-0.5210	8.43e-26	3.42e-26
Cap-dependent-Translation-Initiation	103	4.08e-29	5.92e-27	0.837	0.5510	-0.6300	4.15e-22	1.83e-28
Eukaryotic-Translation-Initiation	103	4.08e-29	5.92e-27	0.837	0.5510	-0.6300	4.15e-22	1.83e-28
Eukaryotic-Translation-Termination	77	4.39e-29	5.92e-27	0.970	0.6460	-0.7230	9.58e-23	4.67e-28
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	79	3.34e-27	4.12e-25	0.925	0.6170	-0.6900	2.42e-21	2.63e-26
Selenocysteine-synthesis	76	9.92e-27	1.13e-24	0.935	0.6240	-0.6960	4.92e-21	7.72e-26
SRP-dependent-cotranslational-protein-targeting-to-membrane	96	6.92e-26	7.33e-24	0.786	0.4650	-0.6330	3.24e-15	6.67e-27
Influenza-Viral-RNA-Transcription-and-Replication	118	8.50e-24	8.40e-22	0.711	0.4890	-0.5160	4.21e-20	3.11e-22
Regulation-of-expression-of-SLITs-and-ROBOs	149	4.28e-23	3.97e-21	0.608	0.3790	-0.4750	1.18e-15	1.16e-23
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	99	5.66e-23	4.66e-21	0.758	0.5070	-0.5640	2.59e-18	2.75e-22
Nonsense-Mediated-Decay-(NMD)	99	5.66e-23	4.66e-21	0.758	0.5070	-0.5640	2.59e-18	2.75e-22
Selenoamino-acid-metabolism	91	3.37e-21	2.63e-19	0.756	0.4960	-0.5700	2.52e-16	5.20e-21
Influenza-Infection	134	1.07e-20	7.91e-19	0.620	0.4230	-0.4540	2.72e-17	1.05e-19
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport	155	3.99e-20	2.82e-18	0.554	0.3440	-0.4340	1.30e-13	8.78e-21
Respiratory-electron-transport	99	3.24e-19	2.19e-17	0.681	0.4300	-0.5270	1.31e-13	1.07e-19
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	107	1.42e-18	9.15e-17	0.643	0.4060	-0.4990	3.53e-13	4.52e-19
Signaling-by-ROBO-receptors	192	3.39e-18	2.10e-16	0.478	0.3060	-0.3670	2.26e-13	1.58e-18
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex	46	2.88e-17	1.71e-15	0.963	0.6600	-0.7010	9.20e-15	1.88e-16
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol	162	6.41e-17	3.65e-15	0.492	0.3000	-0.3900	4.39e-11	9.57e-18
Ribosomal-scanning-and-start-codon-recognition	53	1.26e-15	6.90e-14	0.841	0.5450	-0.6410	6.61e-12	6.60e-16
rRNA-processing	191	1.49e-15	7.91e-14	0.434	0.2650	-0.3440	2.63e-10	2.28e-16
Translation	255	1.99e-15	1.02e-13	0.367	0.2130	-0.2980	4.53e-09	2.01e-16
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S	54	3.11e-15	1.53e-13	0.825	0.5410	-0.6230	6.13e-12	2.24e-15
rRNA-processing-in-the-nucleus-and-cytosol	172	6.74e-15	3.22e-13	0.444	0.2660	-0.3550	1.75e-09	8.42e-16
Translation-initiation-complex-formation	53	1.24e-14	5.72e-13	0.815	0.5320	-0.6170	1.96e-11	7.69e-15
Metabolism-of-amino-acids-and-derivatives	335	1.35e-13	6.06e-12	0.284	0.1470	-0.2430	3.54e-06	1.94e-14
Complex-I-biogenesis	54	7.15e-13	3.12e-11	0.757	0.5000	-0.5680	1.98e-10	5.21e-13
Metabolism	1892	1.65e-12	6.98e-11	0.131	0.0909	-0.0946	3.66e-11	5.66e-12
Extracellular-matrix-organization	274	3.06e-12	1.26e-10	0.217	-0.0423	0.2120	2.27e-01	1.35e-09
Cellular-responses-to-stress	635	5.02e-09	2.01e-07	0.169	0.0905	-0.1430	9.39e-05	6.95e-10
Neuronal-System	352	6.85e-09	2.67e-07	0.124	0.1210	0.0233	8.82e-05	4.52e-01
Cellular-responses-to-stimuli	639	8.37e-09	3.18e-07	0.166	0.0891	-0.1410	1.14e-04	1.17e-09
Gluconeogenesis	30	1.22e-08	4.53e-07	0.824	0.6000	-0.5650	1.25e-08	8.28e-08
Metabolism-of-RNA	646	3.60e-08	1.30e-06	0.128	0.0409	-0.1210	7.52e-02	1.26e-07
Axon-guidance	493	4.10e-08	1.45e-06	0.188	0.1530	-0.1090	5.64e-09	2.99e-05
Ion-channel-transport	167	1.65e-07	5.67e-06	0.202	0.2000	-0.0276	7.78e-06	5.38e-01
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell	94	1.69e-07	5.69e-06	0.419	-0.2580	0.3300	1.50e-05	3.11e-08
Nervous-system-development	517	2.12e-07	6.99e-06	0.176	0.1420	-0.1040	3.20e-08	4.78e-05
Separation-of-Sister-Chromatids	167	5.39e-07	1.74e-05	0.291	0.1640	-0.2410	2.46e-04	7.75e-08
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides	103	6.82e-07	2.15e-05	0.341	0.2990	-0.1640	1.60e-07	3.92e-03
Bicarbonate-transporters	10	1.09e-06	3.36e-05	0.631	0.6220	0.1040	6.55e-04	5.69e-01
Transport-of-small-molecules	677	1.16e-06	3.51e-05	0.145	0.1170	-0.0857	1.82e-07	1.35e-04
Phosphorylation-of-CD3-and-TCR-zeta-chains	17	1.36e-06	4.02e-05	0.896	-0.5230	0.7270	1.86e-04	2.08e-07

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.diab	s.PMX	p.diab	p.PMX
Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency	85	1.11e-34	1.65e-31	1.01000	6.65e-01	-0.757000	2.47e-26	1.35e-33
Viral-mRNA-Translation	73	2.05e-33	1.52e-30	1.07000	7.01e-01	-0.802000	3.15e-25	1.64e-32
Peptide-chain-elongation	73	1.36e-32	6.71e-30	1.05000	6.99e-01	-0.789000	4.63e-25	1.69e-31
Formation-of-a-pool-of-free-40S-subunits	85	2.20e-32	8.16e-30	0.97600	6.53e-01	-0.725000	2.00e-25	5.44e-31
GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit	96	2.23e-31	6.62e-29	0.89500	5.78e-01	-0.684000	1.14e-22	3.98e-31
Eukaryotic-Translation-Elongation	77	2.80e-31	6.91e-29	1.00000	6.65e-01	-0.753000	5.05e-24	2.61e-30
L13a-mediated-translational-silencing-of-Ceruloplasmin-expression	95	4.56e-30	9.66e-28	0.88300	5.74e-01	-0.671000	3.79e-22	1.08e-29
Cellular-response-to-starvation	138	2.09e-29	3.87e-27	0.73400	5.17e-01	-0.521000	8.43e-26	3.42e-26
Cap-dependent-Translation-Initiation	103	4.08e-29	5.92e-27	0.83700	5.51e-01	-0.630000	4.15e-22	1.83e-28
Eukaryotic-Translation-Initiation	103	4.08e-29	5.92e-27	0.83700	5.51e-01	-0.630000	4.15e-22	1.83e-28
Eukaryotic-Translation-Termination	77	4.39e-29	5.92e-27	0.97000	6.46e-01	-0.723000	9.58e-23	4.67e-28
Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)	79	3.34e-27	4.12e-25	0.92500	6.17e-01	-0.690000	2.42e-21	2.63e-26
Selenocysteine-synthesis	76	9.92e-27	1.13e-24	0.93500	6.24e-01	-0.696000	4.92e-21	7.72e-26
SRP-dependent-cotranslational-protein-targeting-to-membrane	96	6.92e-26	7.33e-24	0.78600	4.65e-01	-0.633000	3.24e-15	6.67e-27
Influenza-Viral-RNA-Transcription-and-Replication	118	8.50e-24	8.40e-22	0.71100	4.89e-01	-0.516000	4.21e-20	3.11e-22
Regulation-of-expression-of-SLITs-and-ROBOs	149	4.28e-23	3.97e-21	0.60800	3.79e-01	-0.475000	1.18e-15	1.16e-23
Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)	99	5.66e-23	4.66e-21	0.75800	5.07e-01	-0.564000	2.59e-18	2.75e-22
Nonsense-Mediated-Decay-(NMD)	99	5.66e-23	4.66e-21	0.75800	5.07e-01	-0.564000	2.59e-18	2.75e-22
Selenoamino-acid-metabolism	91	3.37e-21	2.63e-19	0.75600	4.96e-01	-0.570000	2.52e-16	5.20e-21
Influenza-Infection	134	1.07e-20	7.91e-19	0.62000	4.23e-01	-0.454000	2.72e-17	1.05e-19
The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport	155	3.99e-20	2.82e-18	0.55400	3.44e-01	-0.434000	1.30e-13	8.78e-21
Respiratory-electron-transport	99	3.24e-19	2.19e-17	0.68100	4.30e-01	-0.527000	1.31e-13	1.07e-19
Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.	107	1.42e-18	9.15e-17	0.64300	4.06e-01	-0.499000	3.53e-13	4.52e-19
Signaling-by-ROBO-receptors	192	3.39e-18	2.10e-16	0.47800	3.06e-01	-0.367000	2.26e-13	1.58e-18
Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex	46	2.88e-17	1.71e-15	0.96300	6.60e-01	-0.701000	9.20e-15	1.88e-16
Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol	162	6.41e-17	3.65e-15	0.49200	3.00e-01	-0.390000	4.39e-11	9.57e-18
Ribosomal-scanning-and-start-codon-recognition	53	1.26e-15	6.90e-14	0.84100	5.45e-01	-0.641000	6.61e-12	6.60e-16
rRNA-processing	191	1.49e-15	7.91e-14	0.43400	2.65e-01	-0.344000	2.63e-10	2.28e-16
Translation	255	1.99e-15	1.02e-13	0.36700	2.13e-01	-0.298000	4.53e-09	2.01e-16
Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S	54	3.11e-15	1.53e-13	0.82500	5.41e-01	-0.623000	6.13e-12	2.24e-15
rRNA-processing-in-the-nucleus-and-cytosol	172	6.74e-15	3.22e-13	0.44400	2.66e-01	-0.355000	1.75e-09	8.42e-16
Translation-initiation-complex-formation	53	1.24e-14	5.72e-13	0.81500	5.32e-01	-0.617000	1.96e-11	7.69e-15
Metabolism-of-amino-acids-and-derivatives	335	1.35e-13	6.06e-12	0.28400	1.47e-01	-0.243000	3.54e-06	1.94e-14
Complex-I-biogenesis	54	7.15e-13	3.12e-11	0.75700	5.00e-01	-0.568000	1.98e-10	5.21e-13
Metabolism	1892	1.65e-12	6.98e-11	0.13100	9.09e-02	-0.094600	3.66e-11	5.66e-12
Extracellular-matrix-organization	274	3.06e-12	1.26e-10	0.21700	-4.23e-02	0.212000	2.27e-01	1.35e-09
Cellular-responses-to-stress	635	5.02e-09	2.01e-07	0.16900	9.05e-02	-0.143000	9.39e-05	6.95e-10
Neuronal-System	352	6.85e-09	2.67e-07	0.12400	1.21e-01	0.023300	8.82e-05	4.52e-01
Cellular-responses-to-stimuli	639	8.37e-09	3.18e-07	0.16600	8.91e-02	-0.141000	1.14e-04	1.17e-09
Gluconeogenesis	30	1.22e-08	4.53e-07	0.82400	6.00e-01	-0.565000	1.25e-08	8.28e-08
Metabolism-of-RNA	646	3.60e-08	1.30e-06	0.12800	4.09e-02	-0.121000	7.52e-02	1.26e-07
Axon-guidance	493	4.10e-08	1.45e-06	0.18800	1.53e-01	-0.109000	5.64e-09	2.99e-05
Ion-channel-transport	167	1.65e-07	5.67e-06	0.20200	2.00e-01	-0.027600	7.78e-06	5.38e-01
Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell	94	1.69e-07	5.69e-06	0.41900	-2.58e-01	0.330000	1.50e-05	3.11e-08
Nervous-system-development	517	2.12e-07	6.99e-06	0.17600	1.42e-01	-0.104000	3.20e-08	4.78e-05
Separation-of-Sister-Chromatids	167	5.39e-07	1.74e-05	0.29100	1.64e-01	-0.241000	2.46e-04	7.75e-08
Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides	103	6.82e-07	2.15e-05	0.34100	2.99e-01	-0.164000	1.60e-07	3.92e-03
Bicarbonate-transporters	10	1.09e-06	3.36e-05	0.63100	6.22e-01	0.104000	6.55e-04	5.69e-01
Transport-of-small-molecules	677	1.16e-06	3.51e-05	0.14500	1.17e-01	-0.085700	1.82e-07	1.35e-04
Phosphorylation-of-CD3-and-TCR-zeta-chains	17	1.36e-06	4.02e-05	0.89600	-5.23e-01	0.727000	1.86e-04	2.08e-07
CDT1-association-with-the-CDC6:ORC:origin-complex	57	1.85e-06	5.37e-05	0.36300	1.04e-01	-0.348000	1.73e-01	5.49e-06
Glycosaminoglycan-metabolism	113	2.12e-06	6.04e-05	0.27000	-9.19e-02	0.254000	9.13e-02	2.97e-06
PD-1-signaling	17	2.65e-06	7.41e-05	0.89500	-5.55e-01	0.702000	7.37e-05	5.30e-07
Heparan-sulfate/heparin-(HS-GAG)-metabolism	50	2.92e-06	8.01e-05	0.38900	-1.20e-01	0.370000	1.43e-01	6.04e-06
G1/S-DNA-Damage-Checkpoints	64	3.19e-06	8.58e-05	0.36700	1.39e-01	-0.340000	5.40e-02	2.51e-06
Downstream-signaling-events-of-B-Cell-Receptor-(BCR)	79	3.30e-06	8.74e-05	0.27300	4.77e-02	-0.268000	4.63e-01	3.70e-05
NIK–>noncanonical-NF-kB-signaling	57	4.48e-06	1.16e-04	0.31600	5.42e-02	-0.311000	4.79e-01	4.79e-05
Metabolism-of-carbohydrates	266	4.82e-06	1.23e-04	0.09890	6.86e-02	0.071200	5.37e-02	4.54e-02
Dectin-1-mediated-noncanonical-NF-kB-signaling	60	5.21e-06	1.31e-04	0.31300	6.14e-02	-0.306000	4.11e-01	3.98e-05
Defective-CFTR-causes-cystic-fibrosis	59	5.49e-06	1.35e-04	0.22700	-7.31e-02	-0.215000	3.31e-01	4.35e-03
Vif-mediated-degradation-of-APOBEC3G	49	5.56e-06	1.35e-04	0.34400	6.67e-02	-0.338000	4.19e-01	4.31e-05
Cytoprotection-by-HMOX1	118	6.40e-06	1.51e-04	0.21600	3.58e-02	-0.213000	5.02e-01	6.57e-05
Protein-localization	156	6.46e-06	1.51e-04	0.17900	1.96e-02	-0.178000	6.73e-01	1.23e-04
Degradation-of-DVL	55	6.51e-06	1.51e-04	0.33100	7.41e-02	-0.323000	3.42e-01	3.39e-05
A-tetrasaccharide-linker-sequence-is-required-for-GAG-synthesis	24	6.79e-06	1.55e-04	0.59800	-2.44e-01	0.547000	3.87e-02	3.54e-06
Ubiquitin-Mediated-Degradation-of-Phosphorylated-Cdc25A	50	7.30e-06	1.56e-04	0.35000	8.23e-02	-0.340000	3.14e-01	3.21e-05
p53-Independent-DNA-Damage-Response	50	7.30e-06	1.56e-04	0.35000	8.23e-02	-0.340000	3.14e-01	3.21e-05
p53-Independent-G1/S-DNA-damage-checkpoint	50	7.30e-06	1.56e-04	0.35000	8.23e-02	-0.340000	3.14e-01	3.21e-05
p53-Dependent-G1-DNA-Damage-Response	62	7.35e-06	1.56e-04	0.35600	1.30e-01	-0.331000	7.61e-02	6.34e-06
p53-Dependent-G1/S-DNA-damage-checkpoint	62	7.35e-06	1.56e-04	0.35600	1.30e-01	-0.331000	7.61e-02	6.34e-06
APC/C:Cdc20-mediated-degradation-of-Securin	66	7.58e-06	1.58e-04	0.34600	1.28e-01	-0.321000	7.30e-02	6.27e-06
Stabilization-of-p53	54	8.61e-06	1.77e-04	0.33600	8.14e-02	-0.326000	3.00e-01	3.36e-05
Protein-protein-interactions-at-synapses	82	9.40e-06	1.88e-04	0.21400	2.14e-01	0.014400	8.11e-04	8.21e-01
CDK-mediated-phosphorylation-and-removal-of-Cdc6	70	9.40e-06	1.88e-04	0.33200	1.22e-01	-0.309000	7.74e-02	7.76e-06
AUF1-(hnRNP-D0)-binds-and-destabilizes-mRNA	53	9.72e-06	1.92e-04	0.31600	5.29e-02	-0.312000	5.05e-01	8.68e-05
Regulation-of-activated-PAK-2p34-by-proteasome-mediated-degradation	48	9.92e-06	1.94e-04	0.33500	6.03e-02	-0.330000	4.70e-01	7.68e-05
M-Phase	339	1.01e-05	1.95e-04	0.19600	1.37e-01	-0.140000	1.33e-05	8.80e-06
Cell-Cycle-Checkpoints	249	1.04e-05	1.97e-04	0.22700	1.53e-01	-0.168000	3.01e-05	4.81e-06
FCERI-mediated-NF-kB-activation	86	1.18e-05	2.21e-04	0.19900	-2.64e-02	-0.198000	6.73e-01	1.52e-03
SLC-mediated-transmembrane-transport	232	1.26e-05	2.32e-04	0.21500	1.81e-01	-0.117000	2.09e-06	2.09e-03
Cellular-response-to-chemical-stress	151	1.27e-05	2.32e-04	0.17600	1.77e-02	-0.175000	7.07e-01	2.09e-04
APC/C:Cdh1-mediated-degradation-of-Cdc20-and-other-APC/C:Cdh1-targeted-proteins-in-late-mitosis/early-G1	72	1.34e-05	2.41e-04	0.33800	1.39e-01	-0.308000	4.12e-02	6.34e-06
Autodegradation-of-the-E3-ubiquitin-ligase-COP1	50	1.48e-05	2.64e-04	0.33200	7.11e-02	-0.325000	3.84e-01	7.05e-05
Basigin-interactions	24	1.55e-05	2.74e-04	0.65500	5.53e-01	-0.351000	2.67e-06	2.93e-03
Activation-of-APC/C-and-APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	74	1.69e-05	2.95e-04	0.35700	1.76e-01	-0.311000	8.95e-03	3.73e-06
Activation-of-NF-kappaB-in-B-cells	65	1.80e-05	3.10e-04	0.26900	3.46e-02	-0.267000	6.29e-01	1.99e-04
APC/C:Cdc20-mediated-degradation-of-mitotic-proteins	73	1.85e-05	3.13e-04	0.35400	1.70e-01	-0.310000	1.19e-02	4.44e-06
Mitotic-Anaphase	222	1.86e-05	3.13e-04	0.23300	1.53e-01	-0.176000	8.08e-05	6.17e-06
ABC-transporter-disorders	76	1.93e-05	3.22e-04	0.19100	-5.76e-02	-0.182000	3.85e-01	6.09e-03
Translocation-of-ZAP-70-to-Immunological-synapse	14	2.05e-05	3.38e-04	0.89200	-5.35e-01	0.714000	5.27e-04	3.69e-06
Interleukin-1-signaling	96	2.11e-05	3.44e-04	0.28800	1.21e-01	-0.262000	4.08e-02	9.14e-06
Citric-acid-cycle-(TCA-cycle)	22	2.15e-05	3.47e-04	0.73800	5.01e-01	-0.542000	4.71e-05	1.06e-05
Developmental-Biology	833	2.36e-05	3.75e-04	0.11300	9.37e-02	-0.063100	3.91e-06	1.87e-03
Oxygen-dependent-proline-hydroxylation-of-Hypoxia-inducible-Factor-Alpha	62	2.43e-05	3.81e-04	0.25200	7.08e-03	-0.251000	9.23e-01	6.14e-04
Mitotic-Metaphase-and-Anaphase	223	2.44e-05	3.81e-04	0.23000	1.52e-01	-0.173000	9.34e-05	8.34e-06
FBXL7-down-regulates-AURKA-during-mitotic-entry-and-in-early-mitosis	53	2.54e-05	3.92e-04	0.30700	5.64e-02	-0.302000	4.78e-01	1.45e-04
Peroxisomal-protein-import	62	2.78e-05	4.25e-04	0.22000	-2.16e-01	-0.039900	3.25e-03	5.86e-01
Amino-acid-transport-across-the-plasma-membrane	33	2.84e-05	4.29e-04	0.58000	4.55e-01	-0.360000	5.94e-06	3.45e-04
Autodegradation-of-Cdh1-by-Cdh1:APC/C	62	2.93e-05	4.38e-04	0.33000	1.16e-01	-0.309000	1.15e-01	2.61e-05
Glucose-metabolism	85	3.13e-05	4.63e-04	0.35200	2.85e-01	-0.206000	5.39e-06	1.03e-03
Degradation-of-GLI2-by-the-proteasome	57	3.27e-05	4.76e-04	0.25500	1.88e-03	-0.255000	9.80e-01	8.68e-04
Stimuli-sensing-channels	93	3.27e-05	4.76e-04	0.22000	2.18e-01	-0.030200	2.76e-04	6.15e-01
APC:Cdc20-mediated-degradation-of-cell-cycle-proteins-prior-to-satisfation-of-the-cell-cycle-checkpoint	71	3.41e-05	4.87e-04	0.33700	1.50e-01	-0.301000	2.85e-02	1.11e-05
Hh-mutants-abrogate-ligand-secretion	57	3.42e-05	4.87e-04	0.24400	-1.29e-02	-0.244000	8.66e-01	1.43e-03
Chondroitin-sulfate/dermatan-sulfate-metabolism	48	3.46e-05	4.88e-04	0.45300	-2.50e-01	0.378000	2.71e-03	5.89e-06
Cellular-response-to-hypoxia	71	3.70e-05	5.18e-04	0.23700	1.55e-02	-0.236000	8.21e-01	5.73e-04
Negative-regulation-of-NOTCH4-signaling	51	4.08e-05	5.65e-04	0.35500	1.22e-01	-0.333000	1.31e-01	3.78e-05
Regulation-of-HMOX1-expression-and-activity	63	4.11e-05	5.65e-04	0.23400	-6.36e-03	-0.234000	9.30e-01	1.30e-03
Degradation-of-GLI1-by-the-proteasome	57	4.28e-05	5.82e-04	0.24000	-1.51e-02	-0.240000	8.43e-01	1.74e-03
Vpu-mediated-degradation-of-CD4	50	4.41e-05	5.89e-04	0.30400	5.13e-02	-0.299000	5.30e-01	2.50e-04
ER-Phagosome-pathway	81	4.43e-05	5.89e-04	0.23800	3.89e-02	-0.234000	5.45e-01	2.63e-04
Regulation-of-RAS-by-GAPs	66	4.45e-05	5.89e-04	0.26400	4.42e-02	-0.260000	5.34e-01	2.55e-04
Signal-Transduction	2281	4.57e-05	6.00e-04	0.04160	-7.98e-04	0.041600	9.50e-01	9.60e-04
Degradation-of-AXIN	53	4.69e-05	6.10e-04	0.32300	8.81e-02	-0.311000	2.67e-01	9.12e-05
Hh-mutants-are-degraded-by-ERAD	54	4.76e-05	6.13e-04	0.23900	-2.54e-02	-0.238000	7.46e-01	2.51e-03
Cdc20:Phospho-APC/C-mediated-degradation-of-Cyclin-A	70	4.96e-05	6.34e-04	0.32700	1.39e-01	-0.295000	4.36e-02	1.92e-05
SCF-beta-TrCP-mediated-degradation-of-Emi1	53	5.03e-05	6.37e-04	0.29900	5.79e-02	-0.294000	4.66e-01	2.16e-04
Signaling-by-PDGF	53	5.19e-05	6.52e-04	0.41300	-2.18e-01	0.351000	6.10e-03	9.66e-06
Regulation-of-Apoptosis	51	5.54e-05	6.90e-04	0.28200	2.97e-02	-0.281000	7.13e-01	5.24e-04
SCF(Skp2)-mediated-degradation-of-p27/p21	57	6.08e-05	7.51e-04	0.34300	1.33e-01	-0.317000	8.32e-02	3.48e-05
APC/C-mediated-degradation-of-cell-cycle-proteins	85	6.82e-05	8.29e-04	0.31000	1.52e-01	-0.271000	1.56e-02	1.57e-05
Regulation-of-mitotic-cell-cycle	85	6.82e-05	8.29e-04	0.31000	1.52e-01	-0.271000	1.56e-02	1.57e-05
Circadian-Clock	64	7.07e-05	8.50e-04	0.21300	-2.71e-02	-0.211000	7.08e-01	3.51e-03
ROS-sensing-by-NFE2L2	55	7.11e-05	8.50e-04	0.29000	5.73e-02	-0.284000	4.62e-01	2.68e-04
Interaction-between-L1-and-Ankyrins	26	7.45e-05	8.83e-04	0.57700	4.92e-01	-0.302000	1.42e-05	7.58e-03
Regulation-of-ornithine-decarboxylase-(ODC)	50	7.66e-05	9.01e-04	0.28100	3.01e-02	-0.279000	7.12e-01	6.38e-04
GLI3-is-processed-to-GLI3R-by-the-proteasome	57	8.46e-05	9.87e-04	0.26100	2.78e-02	-0.260000	7.16e-01	6.87e-04
Mitochondrial-protein-import	60	9.07e-05	1.05e-03	0.39500	2.29e-01	-0.322000	2.17e-03	1.62e-05
Generation-of-second-messenger-molecules	29	9.31e-05	1.07e-03	0.59800	-4.05e-01	0.440000	1.61e-04	4.15e-05
Cell-Cycle,-Mitotic	479	9.44e-05	1.08e-03	0.14200	1.14e-01	-0.084900	1.78e-05	1.41e-03
Insulin-receptor-recycling	25	1.02e-04	1.15e-03	0.50800	4.67e-01	-0.200000	5.22e-05	8.30e-02
ABC-family-proteins-mediated-transport	97	1.05e-04	1.18e-03	0.19100	1.10e-02	-0.191000	8.52e-01	1.17e-03
Peroxisomal-lipid-metabolism	29	1.07e-04	1.19e-03	0.26500	-2.30e-01	-0.132000	3.21e-02	2.19e-01
Collagen-biosynthesis-and-modifying-enzymes	66	1.14e-04	1.27e-03	0.28300	-8.43e-02	0.270000	2.36e-01	1.48e-04
Asymmetric-localization-of-PCP-proteins	62	1.22e-04	1.34e-03	0.24700	2.77e-02	-0.245000	7.06e-01	8.37e-04
Cell-Cycle	603	1.23e-04	1.34e-03	0.12300	1.01e-01	-0.071000	2.22e-05	2.83e-03
Regulation-of-APC/C-activators-between-G1/S-and-early-anaphase	78	1.29e-04	1.39e-03	0.30100	1.35e-01	-0.269000	3.94e-02	4.03e-05
RHOBTB1-GTPase-cycle	22	1.30e-04	1.40e-03	0.31400	-2.93e-01	-0.113000	1.73e-02	3.58e-01
Switching-of-origins-to-a-post-replicative-state	88	1.42e-04	1.51e-03	0.26100	9.72e-02	-0.242000	1.15e-01	8.68e-05
Regulation-of-mRNA-stability-by-proteins-that-bind-AU-rich-elements	85	1.45e-04	1.53e-03	0.20700	2.11e-02	-0.206000	7.36e-01	1.02e-03
Assembly-of-collagen-fibrils-and-other-multimeric-structures	56	1.50e-04	1.57e-03	0.20400	5.22e-02	0.197000	4.99e-01	1.06e-02
N-glycan-trimming-in-the-ER-and-Calnexin/Calreticulin-cycle	33	1.54e-04	1.60e-03	0.49900	-4.20e-01	0.268000	2.89e-05	7.69e-03
IKK-complex-recruitment-mediated-by-RIP1	21	1.56e-04	1.61e-03	0.48600	1.38e-01	-0.466000	2.74e-01	2.20e-04
The-role-of-GTSE1-in-G2/M-progression-after-G2-checkpoint	58	1.64e-04	1.69e-03	0.30300	9.75e-02	-0.286000	1.99e-01	1.60e-04
Signaling-by-GPCR	575	1.70e-04	1.73e-03	0.05870	2.86e-02	0.051300	2.40e-01	3.49e-02
HS-GAG-degradation	20	1.79e-04	1.82e-03	0.65100	-3.70e-01	0.536000	4.19e-03	3.27e-05
Transferrin-endocytosis-and-recycling	29	1.98e-04	2.00e-03	0.44500	4.13e-01	-0.166000	1.18e-04	1.21e-01
Crosslinking-of-collagen-fibrils	10	2.40e-04	2.41e-03	0.42300	3.44e-01	0.247000	5.98e-02	1.76e-01
TICAM1,-RIP1-mediated-IKK-complex-recruitment	17	2.54e-04	2.52e-03	0.54800	1.80e-01	-0.518000	1.98e-01	2.19e-04
Orc1-removal-from-chromatin	68	2.65e-04	2.61e-03	0.26300	7.53e-02	-0.252000	2.83e-01	3.33e-04
Collagen-formation	88	2.66e-04	2.61e-03	0.17100	1.65e-02	0.171000	7.89e-01	5.63e-03
Response-of-EIF2AK1-(HRI)-to-heme-deficiency	15	2.72e-04	2.65e-03	0.75900	4.66e-01	-0.599000	1.76e-03	5.85e-05
Diseases-of-glycosylation	130	2.88e-04	2.79e-03	0.13700	1.86e-02	0.136000	7.15e-01	7.33e-03
Ubiquitin-dependent-degradation-of-Cyclin-D	50	3.08e-04	2.96e-03	0.30300	8.63e-02	-0.290000	2.91e-01	3.83e-04
Transmission-across-Chemical-Synapses	227	3.10e-04	2.96e-03	0.11000	1.09e-01	0.004750	4.45e-03	9.02e-01
Mitochondrial-tRNA-aminoacylation	18	3.13e-04	2.97e-03	0.70500	-5.26e-01	0.468000	1.10e-04	5.79e-04
CD22-mediated-BCR-regulation	17	3.16e-04	2.98e-03	0.71200	-5.55e-01	0.447000	7.52e-05	1.40e-03
Plasma-lipoprotein-remodeling	30	3.18e-04	2.98e-03	0.43000	1.65e-01	-0.397000	1.18e-01	1.67e-04
Metabolism-of-proteins	1703	3.27e-04	3.05e-03	0.07420	4.85e-02	-0.056100	7.70e-04	1.01e-04
CLEC7A-(Dectin-1)-signaling	97	3.29e-04	3.05e-03	0.24800	1.05e-01	-0.225000	7.42e-02	1.25e-04
Cross-presentation-of-soluble-exogenous-antigens-(endosomes)	48	3.35e-04	3.08e-03	0.27400	4.25e-02	-0.270000	6.10e-01	1.19e-03
Hedgehog-ligand-biogenesis	63	3.59e-04	3.28e-03	0.18400	-4.42e-02	-0.179000	5.44e-01	1.41e-02
Mitotic-Spindle-Checkpoint	108	3.62e-04	3.29e-03	0.28300	2.16e-01	-0.183000	1.03e-04	9.83e-04
Platelet-calcium-homeostasis	27	3.67e-04	3.32e-03	0.39700	3.84e-01	-0.103000	5.57e-04	3.56e-01
Pyruvate-metabolism-and-Citric-Acid-(TCA)-cycle	52	3.74e-04	3.36e-03	0.38900	2.23e-01	-0.318000	5.34e-03	7.15e-05
Muscle-contraction	174	4.08e-04	3.64e-03	0.10700	1.02e-01	0.031900	1.96e-02	4.68e-01
Resolution-of-Sister-Chromatid-Cohesion	104	4.25e-04	3.77e-03	0.29000	2.09e-01	-0.201000	2.30e-04	3.99e-04
PCP/CE-pathway	88	4.54e-04	4.00e-03	0.18400	1.15e-02	-0.184000	8.52e-01	2.84e-03
Mitochondrial-translation-initiation	86	4.64e-04	4.05e-03	0.31700	2.24e-01	-0.224000	3.22e-04	3.24e-04
L1CAM-interactions	95	4.64e-04	4.05e-03	0.20000	1.95e-01	-0.041900	9.90e-04	4.80e-01
Fatty-acid-metabolism	155	4.94e-04	4.26e-03	0.13700	6.68e-03	-0.137000	8.86e-01	3.27e-03
Signaling-by-Hippo	20	4.95e-04	4.26e-03	0.34100	-3.39e-01	-0.040300	8.75e-03	7.55e-01
Signaling-by-NTRK3-(TRKC)	17	5.04e-04	4.32e-03	0.33500	3.18e-01	0.106000	2.33e-02	4.49e-01
Assembly-of-the-pre-replicative-complex	66	5.28e-04	4.50e-03	0.27500	1.00e-01	-0.256000	1.58e-01	3.13e-04
Mitochondrial-translation-termination	86	5.32e-04	4.51e-03	0.31400	2.20e-01	-0.224000	4.06e-04	3.31e-04
RHOB-GTPase-cycle	69	5.54e-04	4.66e-03	0.15200	1.01e-01	0.113000	1.46e-01	1.05e-01
Antigen-processing-Cross-presentation	95	5.64e-04	4.72e-03	0.17800	1.53e-02	-0.177000	7.97e-01	2.79e-03
Formation-of-the-beta-catenin:TCF-transactivating-complex	32	5.96e-04	4.96e-03	0.44400	-2.17e-01	0.388000	3.36e-02	1.46e-04
Regulation-of-PTEN-stability-and-activity	66	6.16e-04	5.10e-03	0.24200	5.86e-02	-0.235000	4.10e-01	9.61e-04
Regulation-of-RUNX3-expression-and-activity	52	6.40e-04	5.27e-03	0.25700	4.53e-02	-0.253000	5.72e-01	1.62e-03
Defective-B3GAT3-causes-JDSSDHD	18	6.49e-04	5.31e-03	0.52400	-1.95e-01	0.486000	1.51e-01	3.54e-04
Mitochondrial-translation-elongation	86	6.76e-04	5.50e-03	0.30900	2.21e-01	-0.217000	4.03e-04	5.13e-04
Interleukin-1-family-signaling	130	6.94e-04	5.62e-03	0.21000	9.43e-02	-0.188000	6.33e-02	2.16e-04
Signaling-by-Receptor-Tyrosine-Kinases	482	7.02e-04	5.65e-03	0.12000	-6.50e-02	0.101000	1.43e-02	1.42e-04
RHOA-GTPase-cycle	144	7.26e-04	5.81e-03	0.14100	-9.92e-03	0.140000	8.37e-01	3.63e-03
Integrin-cell-surface-interactions	64	7.60e-04	6.05e-03	0.25100	-6.97e-02	0.241000	3.35e-01	8.62e-04
MAPK6/MAPK4-signaling	85	7.64e-04	6.05e-03	0.20600	4.56e-02	-0.201000	4.67e-01	1.33e-03
Defective-B3GALT6-causes-EDSP2-and-SEMDJL1	18	7.95e-04	6.27e-03	0.52500	-2.03e-01	0.484000	1.35e-01	3.81e-04
Cargo-trafficking-to-the-periciliary-membrane	49	8.08e-04	6.34e-03	0.40200	-2.68e-01	0.299000	1.18e-03	2.87e-04
HS-GAG-biosynthesis	28	8.13e-04	6.34e-03	0.25900	6.70e-02	0.250000	5.40e-01	2.18e-02
Metabolism-of-polyamines	58	8.28e-04	6.43e-03	0.21300	7.34e-03	-0.213000	9.23e-01	4.93e-03
GPCR-downstream-signalling	513	8.58e-04	6.62e-03	0.05970	1.80e-02	0.056900	4.85e-01	2.69e-02
Laminin-interactions	23	8.65e-04	6.64e-03	0.25400	1.83e-01	0.176000	1.29e-01	1.43e-01
FCGR-activation	24	8.93e-04	6.82e-03	0.56200	-4.34e-01	0.357000	2.32e-04	2.43e-03
Amplification–of-signal-from-unattached–kinetochores-via-a-MAD2–inhibitory-signal	91	9.22e-04	6.97e-03	0.28600	2.24e-01	-0.179000	2.21e-04	3.20e-03
Amplification-of-signal-from-the-kinetochores	91	9.22e-04	6.97e-03	0.28600	2.24e-01	-0.179000	2.21e-04	3.20e-03
Receptor-type-tyrosine-protein-phosphatases	19	9.92e-04	7.46e-03	0.40100	3.97e-01	-0.058200	2.76e-03	6.60e-01
Other-semaphorin-interactions	19	1.00e-03	7.51e-03	0.44800	-1.22e-01	0.431000	3.57e-01	1.13e-03
Synaptic-adhesion-like-molecules	21	1.05e-03	7.80e-03	0.42600	4.10e-01	-0.117000	1.15e-03	3.52e-01
Regulation-of-KIT-signaling	16	1.06e-03	7.88e-03	0.67100	-4.12e-01	0.530000	4.28e-03	2.42e-04
Beta-oxidation-of-very-long-chain-fatty-acids	11	1.12e-03	8.23e-03	0.37200	-1.81e-01	-0.325000	2.98e-01	6.20e-02
RHO-GTPase-Effectors	236	1.15e-03	8.47e-03	0.17300	1.38e-01	-0.105000	2.54e-04	5.39e-03
Cardiac-conduction	112	1.17e-03	8.55e-03	0.13500	1.34e-01	0.018000	1.46e-02	7.42e-01
Diseases-associated-with-O-glycosylation-of-proteins	62	1.19e-03	8.66e-03	0.15100	1.08e-01	0.106000	1.40e-01	1.50e-01
Metabolism-of-steroids	139	1.25e-03	9.03e-03	0.16000	3.99e-02	-0.155000	4.17e-01	1.60e-03
Cyclin-E-associated-events-during-G1/S-transition	80	1.26e-03	9.09e-03	0.24500	9.84e-02	-0.224000	1.28e-01	5.34e-04
Defective-GALNT12-causes-colorectal-cancer-1-(CRCS1)	12	1.35e-03	9.66e-03	0.72900	6.06e-01	-0.405000	2.78e-04	1.50e-02
Defective-B4GALT7-causes-EDS,-progeroid-type	18	1.40e-03	1.00e-02	0.48800	-1.74e-01	0.456000	2.00e-01	8.11e-04
Glycerophospholipid-biosynthesis	114	1.43e-03	1.01e-02	0.25300	1.87e-01	-0.171000	5.46e-04	1.64e-03
tRNA-Aminoacylation	23	1.44e-03	1.01e-02	0.56500	-4.10e-01	0.388000	6.68e-04	1.26e-03
Kinesins	40	1.47e-03	1.03e-02	0.27900	2.74e-01	-0.053500	2.71e-03	5.58e-01
RHOBTB-GTPase-Cycle	32	1.52e-03	1.05e-02	0.28100	-2.80e-01	0.018400	6.02e-03	8.57e-01
Collagen-chain-trimerization	43	1.52e-03	1.05e-02	0.31500	-1.13e-01	0.294000	1.98e-01	8.58e-04
CDC42-GTPase-cycle	156	1.53e-03	1.05e-02	0.14600	-3.35e-02	0.142000	4.70e-01	2.17e-03
UCH-proteinases	83	1.53e-03	1.05e-02	0.16200	-6.30e-03	-0.162000	9.21e-01	1.06e-02
Interleukin-3,-Interleukin-5-and-GM-CSF-signaling	40	1.54e-03	1.05e-02	0.42600	-2.93e-01	0.310000	1.36e-03	7.02e-04
Cohesin-Loading-onto-Chromatin	10	1.54e-03	1.05e-02	0.39500	-1.47e-01	-0.366000	4.21e-01	4.49e-02
Elastic-fibre-formation	39	1.63e-03	1.11e-02	0.20400	6.35e-02	0.194000	4.93e-01	3.62e-02
Mitochondrial-Fatty-Acid-Beta-Oxidation	34	1.63e-03	1.11e-02	0.32000	8.39e-02	-0.309000	3.97e-01	1.83e-03
Amino-acids-regulate-mTORC1	53	1.65e-03	1.11e-02	0.31000	2.76e-01	-0.141000	5.01e-04	7.65e-02
Elevation-of-cytosolic-Ca2+-levels	15	1.71e-03	1.15e-02	0.51900	4.87e-01	-0.177000	1.08e-03	2.34e-01
Hedgehog-‘on’-state	83	1.74e-03	1.16e-02	0.13100	-6.60e-02	-0.113000	2.98e-01	7.60e-02
Mitotic-Prometaphase	182	1.75e-03	1.16e-02	0.19700	1.48e-01	-0.130000	5.81e-04	2.43e-03
Signaling-by-Hedgehog	132	1.86e-03	1.23e-02	0.17900	-1.66e-01	0.065800	9.76e-04	1.91e-01
ECM-proteoglycans	51	1.87e-03	1.23e-02	0.24300	-4.67e-02	0.238000	5.64e-01	3.23e-03
Calnexin/calreticulin-cycle	24	1.91e-03	1.25e-02	0.48500	-4.15e-01	0.251000	4.36e-04	3.35e-02
EML4-and-NUDC-in-mitotic-spindle-formation	95	1.93e-03	1.26e-02	0.26300	2.08e-01	-0.161000	4.50e-04	6.53e-03
Interleukin-2-family-signaling	40	1.94e-03	1.26e-02	0.41100	-2.61e-01	0.317000	4.26e-03	5.16e-04
Organic-cation/anion/zwitterion-transport	12	1.99e-03	1.29e-02	0.75700	-5.02e-01	0.567000	2.61e-03	6.75e-04
Metabolism-of-lipids	674	2.01e-03	1.30e-02	0.07690	2.59e-02	-0.072400	2.50e-01	1.30e-03
tRNA-processing-in-the-mitochondrion	16	2.12e-03	1.36e-02	0.65700	4.74e-01	-0.455000	1.04e-03	1.62e-03
C-type-lectin-receptors-(CLRs)	129	2.16e-03	1.38e-02	0.20200	9.86e-02	-0.176000	5.29e-02	5.52e-04
Membrane-Trafficking	578	2.43e-03	1.54e-02	0.10300	8.41e-02	-0.060200	5.27e-04	1.30e-02
Synthesis-of-PE	12	2.52e-03	1.60e-02	0.74800	5.28e-01	-0.530000	1.52e-03	1.48e-03
mitochondrial-fatty-acid-beta-oxidation-of-saturated-fatty-acids	10	2.56e-03	1.61e-02	0.35400	-2.52e-01	-0.249000	1.68e-01	1.72e-01
Signaling-by-the-B-Cell-Receptor-(BCR)	120	2.66e-03	1.67e-02	0.10200	-6.58e-02	-0.078500	2.13e-01	1.37e-01
RUNX1-interacts-with-co-factors-whose-precise-effect-on-RUNX1-targets-is-not-known	36	2.77e-03	1.73e-02	0.41100	-3.29e-01	0.246000	6.28e-04	1.06e-02
Signaling-by-Rho-GTPases,-Miro-GTPases-and-RHOBTB3	622	2.83e-03	1.76e-02	0.04740	4.31e-02	0.019700	6.54e-02	3.99e-01
alpha-linolenic-(omega3)-and-linoleic-(omega6)-acid-metabolism	12	2.91e-03	1.79e-02	0.47200	7.89e-02	-0.465000	6.36e-01	5.25e-03
alpha-linolenic-acid-(ALA)-metabolism	12	2.91e-03	1.79e-02	0.47200	7.89e-02	-0.465000	6.36e-01	5.25e-03
Synthesis-of-DNA	117	2.91e-03	1.79e-02	0.20700	1.01e-01	-0.180000	5.79e-02	7.49e-04
RHO-GTPases-Activate-Formins	115	3.07e-03	1.88e-02	0.23800	1.73e-01	-0.163000	1.35e-03	2.50e-03
Fc-epsilon-receptor-(FCERI)-signaling	138	3.08e-03	1.88e-02	0.12500	4.13e-03	-0.125000	9.33e-01	1.12e-02
Ub-specific-processing-proteases	158	3.16e-03	1.92e-02	0.16000	6.26e-02	-0.147000	1.74e-01	1.39e-03
STING-mediated-induction-of-host-immune-responses	12	3.31e-03	2.00e-02	0.71800	-4.59e-01	0.552000	5.94e-03	9.18e-04
MHC-class-II-antigen-presentation	95	3.33e-03	2.00e-02	0.22800	1.98e-01	-0.114000	8.40e-04	5.56e-02
Downstream-TCR-signaling	89	3.37e-03	2.02e-02	0.11900	-6.02e-02	-0.103000	3.26e-01	9.28e-02
Acetylcholine-regulates-insulin-secretion	10	3.40e-03	2.03e-02	0.79100	-5.20e-01	0.596000	4.40e-03	1.09e-03
NOTCH3-Intracellular-Domain-Regulates-Transcription	25	3.41e-03	2.03e-02	0.48100	-2.84e-01	0.389000	1.39e-02	7.67e-04
RMTs-methylate-histone-arginines	29	3.44e-03	2.04e-02	0.45400	-2.78e-01	0.358000	9.50e-03	8.32e-04
Cytosolic-iron-sulfur-cluster-assembly	11	3.53e-03	2.09e-02	0.36800	3.56e-01	0.094800	4.09e-02	5.86e-01
BBSome-mediated-cargo-targeting-to-cilium	21	3.65e-03	2.15e-02	0.54100	-4.11e-01	0.352000	1.11e-03	5.27e-03
DNA-Replication	124	3.76e-03	2.20e-02	0.20500	1.09e-01	-0.173000	3.55e-02	8.59e-04
Costimulation-by-the-CD28-family	63	3.81e-03	2.22e-02	0.29500	-1.67e-01	0.243000	2.15e-02	8.44e-04
Plasma-lipoprotein-assembly,-remodeling,-and-clearance	68	3.89e-03	2.26e-02	0.20300	4.55e-02	-0.198000	5.16e-01	4.70e-03
TNFR2-non-canonical-NF-kB-pathway	94	4.01e-03	2.32e-02	0.16000	2.17e-02	-0.158000	7.16e-01	7.90e-03
Antigen-activates-B-Cell-Receptor-(BCR)-leading-to-generation-of-second-messengers	42	4.05e-03	2.34e-02	0.38300	-2.79e-01	0.263000	1.74e-03	3.22e-03
DNA-Replication-Pre-Initiation	82	4.15e-03	2.38e-02	0.20700	7.24e-02	-0.194000	2.57e-01	2.33e-03
Semaphorin-interactions	63	4.24e-03	2.42e-02	0.15200	3.87e-02	0.147000	5.95e-01	4.39e-02
RHO-GTPase-cycle	436	4.47e-03	2.55e-02	0.07700	-1.41e-02	0.075700	6.12e-01	6.60e-03
Platelet-homeostasis	83	4.66e-03	2.65e-02	0.15800	1.58e-01	-0.009010	1.30e-02	8.87e-01
Cyclin-A:Cdk2-associated-events-at-S-phase-entry	82	4.69e-03	2.65e-02	0.22500	9.87e-02	-0.202000	1.22e-01	1.56e-03
Plasma-lipoprotein-assembly	17	4.75e-03	2.67e-02	0.40600	9.87e-02	-0.394000	4.81e-01	4.94e-03
Transcriptional-Regulation-by-TP53	338	4.79e-03	2.69e-02	0.11100	9.96e-02	-0.048400	1.61e-03	1.25e-01
Degradation-of-beta-catenin-by-the-destruction-complex	82	4.80e-03	2.69e-02	0.23900	1.20e-01	-0.207000	5.93e-02	1.21e-03
Glutamate-and-glutamine-metabolism	12	4.90e-03	2.72e-02	0.70000	4.63e-01	-0.525000	5.49e-03	1.65e-03
RHOC-GTPase-cycle	71	4.91e-03	2.72e-02	0.19900	-4.93e-02	0.193000	4.73e-01	4.94e-03
RAC2-GTPase-cycle	86	5.11e-03	2.82e-02	0.22400	-1.05e-01	0.198000	9.34e-02	1.49e-03
Signaling-by-SCF-KIT	42	5.16e-03	2.84e-02	0.36000	-2.17e-01	0.288000	1.52e-02	1.23e-03
Signaling-by-Rho-GTPases	607	5.17e-03	2.84e-02	0.04330	3.34e-02	0.027600	1.59e-01	2.44e-01
Cilium-Assembly	174	5.33e-03	2.92e-02	0.16300	-8.18e-02	0.141000	6.26e-02	1.36e-03
RUNX1-regulates-transcription-of-genes-involved-in-differentiation-of-HSCs	69	5.56e-03	3.03e-02	0.16100	-3.07e-03	-0.161000	9.65e-01	2.04e-02
O-linked-glycosylation	98	5.58e-03	3.03e-02	0.13600	1.04e-03	0.136000	9.86e-01	1.95e-02
GPVI-mediated-activation-cascade	31	5.70e-03	3.08e-02	0.43000	-2.85e-01	0.321000	6.04e-03	1.94e-03
SLC-transporter-disorders	93	5.71e-03	3.08e-02	0.13900	1.39e-01	0.001500	2.00e-02	9.80e-01
Glycolysis	66	5.74e-03	3.08e-02	0.24900	2.22e-01	-0.113000	1.79e-03	1.12e-01
SUMOylation-of-intracellular-receptors	30	5.80e-03	3.10e-02	0.26500	-2.64e-01	0.026300	1.23e-02	8.03e-01
Neurotransmitter-receptors-and-postsynaptic-signal-transmission	167	5.81e-03	3.10e-02	0.08130	6.41e-02	0.050000	1.53e-01	2.65e-01
LGI-ADAM-interactions	13	5.83e-03	3.10e-02	0.30700	1.18e-01	0.284000	4.61e-01	7.64e-02
Prefoldin-mediated-transfer-of-substrate–to-CCT/TriC	24	6.05e-03	3.20e-02	0.22700	-2.12e-01	-0.082100	7.23e-02	4.86e-01
Regulation-of-insulin-secretion	75	6.07e-03	3.20e-02	0.16300	1.62e-01	-0.010300	1.50e-02	8.77e-01
Chemokine-receptors-bind-chemokines	42	6.12e-03	3.22e-02	0.36800	-2.49e-01	0.271000	5.17e-03	2.39e-03
Synthesis,-secretion,-and-inactivation-of-Glucose-dependent-Insulinotropic-Polypeptide-(GIP)	11	6.34e-03	3.32e-02	0.37500	-4.45e-02	-0.372000	7.98e-01	3.26e-02
TCR-signaling	111	6.40e-03	3.34e-02	0.11700	-1.16e-01	-0.016000	3.50e-02	7.71e-01
PPARA-activates-gene-expression	114	6.42e-03	3.34e-02	0.09710	-7.48e-02	-0.061900	1.68e-01	2.53e-01
Neurexins-and-neuroligins	52	6.53e-03	3.38e-02	0.14300	9.16e-02	0.110000	2.53e-01	1.69e-01
Mitochondrial-translation	92	6.59e-03	3.40e-02	0.24700	1.67e-01	-0.182000	5.68e-03	2.51e-03
Regulation-of-lipid-metabolism-by-PPARalpha	116	6.94e-03	3.56e-02	0.09520	-7.01e-02	-0.064400	1.92e-01	2.30e-01
Heme-signaling	45	6.95e-03	3.56e-02	0.23900	-2.32e-01	0.056300	7.03e-03	5.13e-01
CRMPs-in-Sema3A-signaling	16	6.97e-03	3.56e-02	0.25600	1.90e-01	0.171000	1.88e-01	2.36e-01
Dual-Incision-in-GG-NER	40	7.17e-03	3.65e-02	0.20700	2.07e-01	0.003680	2.36e-02	9.68e-01
Termination-of-O-glycan-biosynthesis	19	7.35e-03	3.73e-02	0.39500	3.74e-01	-0.125000	4.72e-03	3.45e-01
SEMA3A-Plexin-repulsion-signaling-by-inhibiting-Integrin-adhesion	14	7.60e-03	3.84e-02	0.30200	8.07e-02	0.291000	6.01e-01	5.91e-02
Defective-EXT1-causes-exostoses-1,-TRPS2-and-CHDS	13	7.71e-03	3.85e-02	0.42600	-8.49e-02	0.417000	5.96e-01	9.22e-03
Defective-EXT2-causes-exostoses-2	13	7.71e-03	3.85e-02	0.42600	-8.49e-02	0.417000	5.96e-01	9.22e-03
Binding-and-Uptake-of-Ligands-by-Scavenger-Receptors	50	7.74e-03	3.85e-02	0.29600	-1.53e-01	0.253000	6.04e-02	1.94e-03
The-role-of-Nef-in-HIV-1-replication-and-disease-pathogenesis	27	7.75e-03	3.85e-02	0.36800	-1.58e-01	0.333000	1.56e-01	2.75e-03
Post-NMDA-receptor-activation-events	61	7.76e-03	3.85e-02	0.22000	2.09e-01	-0.070800	4.83e-03	3.38e-01
Activation-of-NMDA-receptors-and-postsynaptic-events	74	7.78e-03	3.85e-02	0.16800	1.67e-01	-0.021400	1.32e-02	7.50e-01
Diseases-associated-with-glycosaminoglycan-metabolism	36	8.05e-03	3.97e-02	0.32000	-1.39e-01	0.288000	1.50e-01	2.78e-03
Regulation-of-RUNX2-expression-and-activity	68	8.07e-03	3.97e-02	0.14500	-2.17e-02	-0.143000	7.57e-01	4.14e-02
DDX58/IFIH1-mediated-induction-of-interferon-alpha/beta	61	8.70e-03	4.27e-02	0.18700	2.89e-02	-0.185000	6.96e-01	1.26e-02
Alpha-protein-kinase-1-signaling-pathway	10	8.73e-03	4.27e-02	0.70300	4.27e-01	-0.559000	1.93e-02	2.20e-03
Branched-chain-amino-acid-catabolism	21	8.81e-03	4.29e-02	0.32900	-3.23e-01	0.064100	1.05e-02	6.11e-01
Interleukin-2-signaling	11	8.99e-03	4.37e-02	0.68700	-5.18e-01	0.451000	2.94e-03	9.61e-03
Phospholipid-metabolism	195	9.06e-03	4.39e-02	0.13700	1.23e-01	-0.060900	3.00e-03	1.42e-01
IRF3-mediated-induction-of-type-I-IFN	10	9.15e-03	4.42e-02	0.67500	-3.77e-01	0.559000	3.89e-02	2.19e-03
Cellular-hexose-transport	19	9.40e-03	4.52e-02	0.25300	2.43e-01	0.069400	6.64e-02	6.01e-01
Hedgehog-‘off’-state	96	9.42e-03	4.52e-02	0.11200	-1.07e-01	-0.032200	6.91e-02	5.86e-01
NCAM1-interactions	36	9.52e-03	4.55e-02	0.21400	-3.90e-04	0.214000	9.97e-01	2.59e-02
Fertilization	19	1.03e-02	4.92e-02	0.50000	3.99e-01	-0.302000	2.62e-03	2.26e-02
Glutamate-Neurotransmitter-Release-Cycle	24	1.05e-02	4.97e-02	0.43900	3.55e-01	-0.258000	2.57e-03	2.88e-02
Resolution-of-Abasic-Sites-(AP-sites)	37	1.07e-02	5.06e-02	0.20700	2.07e-01	0.002800	2.95e-02	9.77e-01
RHOBTB2-GTPase-cycle	20	1.09e-02	5.16e-02	0.40500	-3.69e-01	0.166000	4.22e-03	1.98e-01
RORA-activates-gene-expression	17	1.12e-02	5.28e-02	0.23600	-1.75e-01	-0.158000	2.12e-01	2.58e-01
S-Phase	159	1.13e-02	5.32e-02	0.16100	8.40e-02	-0.137000	6.72e-02	2.89e-03
WNT-ligand-biogenesis-and-trafficking	23	1.16e-02	5.41e-02	0.44100	2.56e-01	-0.359000	3.38e-02	2.84e-03
Neddylation	224	1.16e-02	5.42e-02	0.11000	3.46e-02	-0.104000	3.71e-01	7.19e-03
Mitotic-Telophase/Cytokinesis	13	1.17e-02	5.45e-02	0.39700	6.79e-02	-0.391000	6.72e-01	1.46e-02
Transcriptional-Regulation-by-MECP2	55	1.18e-02	5.46e-02	0.26900	-2.31e-01	0.138000	3.08e-03	7.68e-02
G-alpha-(q)-signalling-events	183	1.20e-02	5.56e-02	0.07550	3.10e-02	0.068800	4.69e-01	1.08e-01
Infectious-disease	735	1.27e-02	5.86e-02	0.08190	5.38e-02	-0.061700	1.27e-02	4.22e-03
Synthesis,-secretion,-and-deacylation-of-Ghrelin	15	1.28e-02	5.88e-02	0.40400	1.13e-01	-0.388000	4.47e-01	9.33e-03
Signaling-by-ERBB2-in-Cancer	25	1.34e-02	6.13e-02	0.24100	-8.99e-03	-0.241000	9.38e-01	3.69e-02
NCAM-signaling-for-neurite-out-growth	57	1.37e-02	6.25e-02	0.12800	7.16e-02	0.106000	3.50e-01	1.66e-01
Diseases-of-signal-transduction-by-growth-factor-receptors-and-second-messengers	412	1.38e-02	6.26e-02	0.04860	-4.24e-02	-0.023800	1.39e-01	4.07e-01
Mitotic-G2-G2/M-phases	178	1.38e-02	6.27e-02	0.15900	9.65e-02	-0.126000	2.61e-02	3.64e-03
ATF6-(ATF6-alpha)-activates-chaperones	12	1.39e-02	6.27e-02	0.54600	-4.79e-01	0.262000	4.05e-03	1.16e-01
PRC2-methylates-histones-and-DNA	14	1.42e-02	6.39e-02	0.52900	-4.49e-01	0.279000	3.65e-03	7.02e-02
Non-integrin-membrane-ECM-interactions	42	1.42e-02	6.40e-02	0.23800	-6.61e-02	0.229000	4.58e-01	1.04e-02
FCGR3A-mediated-IL10-synthesis	49	1.43e-02	6.41e-02	0.30600	-1.94e-01	0.237000	1.89e-02	4.16e-03
Budding-and-maturation-of-HIV-virion	25	1.47e-02	6.58e-02	0.43500	3.15e-01	-0.300000	6.39e-03	9.48e-03
Keratinization	59	1.50e-02	6.66e-02	0.28200	2.09e-01	-0.189000	5.52e-03	1.21e-02
Defective-B3GALTL-causes-Peters-plus-syndrome-(PpS)	37	1.50e-02	6.67e-02	0.17700	3.81e-02	0.173000	6.89e-01	6.91e-02
Anti-inflammatory-response-favouring-Leishmania-parasite-infection	152	1.54e-02	6.81e-02	0.14500	-6.24e-02	0.130000	1.84e-01	5.46e-03
Leishmania-parasite-growth-and-survival	152	1.54e-02	6.81e-02	0.14500	-6.24e-02	0.130000	1.84e-01	5.46e-03
Transcriptional-regulation-by-RUNX3	93	1.55e-02	6.83e-02	0.11200	-2.28e-02	-0.109000	7.04e-01	6.80e-02
Endosomal-Sorting-Complex-Required-For-Transport-(ESCRT)	28	1.56e-02	6.84e-02	0.40300	3.07e-01	-0.260000	4.88e-03	1.70e-02
Pentose-phosphate-pathway	12	1.61e-02	7.06e-02	0.29400	2.79e-01	0.093200	9.47e-02	5.76e-01
Inositol-phosphate-metabolism	46	1.62e-02	7.07e-02	0.13800	8.52e-02	0.109000	3.17e-01	2.02e-01
Inactivation-of-CSF3-(G-CSF)-signaling	22	1.64e-02	7.11e-02	0.21100	-1.94e-01	-0.082800	1.16e-01	5.01e-01
GPCR-ligand-binding	353	1.64e-02	7.11e-02	0.05630	1.35e-02	0.054700	6.64e-01	7.70e-02
Intraflagellar-transport	34	1.65e-02	7.15e-02	0.34200	-1.91e-01	0.284000	5.39e-02	4.19e-03
DNA-strand-elongation	32	1.67e-02	7.19e-02	0.16500	1.29e-01	0.103000	2.08e-01	3.13e-01
G2/M-Transition	176	1.67e-02	7.19e-02	0.15300	8.87e-02	-0.125000	4.22e-02	4.26e-03
Synthesis-of-PIPs-at-the-plasma-membrane	52	1.69e-02	7.25e-02	0.15100	2.46e-02	0.149000	7.59e-01	6.29e-02
Serotonin-Neurotransmitter-Release-Cycle	18	1.72e-02	7.33e-02	0.35300	3.39e-01	-0.095100	1.26e-02	4.85e-01
Cristae-formation	13	1.72e-02	7.34e-02	0.53400	4.55e-01	-0.281000	4.54e-03	7.96e-02
Signaling-by-NOTCH3	48	1.73e-02	7.35e-02	0.30800	-2.13e-01	0.222000	1.06e-02	7.67e-03
Erythropoietin-activates-Phosphoinositide-3-kinase-(PI3K)	12	1.74e-02	7.39e-02	0.29400	-2.81e-01	-0.085800	9.14e-02	6.07e-01
Lysosphingolipid-and-LPA-receptors	14	1.81e-02	7.63e-02	0.26400	2.47e-01	0.093400	1.09e-01	5.45e-01
NF-kB-activation-through-FADD/RIP-1-pathway-mediated-by-caspase-8-and–10	11	1.81e-02	7.63e-02	0.31000	-8.18e-02	-0.299000	6.39e-01	8.64e-02
ROS-and-RNS-production-in-phagocytes	35	1.85e-02	7.74e-02	0.20900	2.09e-01	-0.011000	3.27e-02	9.10e-01
ABC-transporters-in-lipid-homeostasis	17	1.85e-02	7.74e-02	0.45400	2.29e-01	-0.392000	1.02e-01	5.13e-03
O-glycosylation-of-TSR-domain-containing-proteins	38	1.86e-02	7.76e-02	0.16100	5.34e-02	0.152000	5.69e-01	1.04e-01
HDR-through-Single-Strand-Annealing-(SSA)	37	1.88e-02	7.84e-02	0.19700	1.97e-01	-0.002210	3.84e-02	9.81e-01
Deadenylation-of-mRNA	24	1.89e-02	7.85e-02	0.23800	-2.38e-01	-0.005810	4.34e-02	9.61e-01
Transcriptional-activity-of-SMAD2/SMAD3:SMAD4-heterotrimer	43	1.90e-02	7.88e-02	0.16900	-1.69e-01	-0.017300	5.58e-02	8.44e-01
Hemostasis	535	1.98e-02	8.16e-02	0.05210	-8.66e-04	0.052100	9.73e-01	3.89e-02
Norepinephrine-Neurotransmitter-Release-Cycle	18	1.98e-02	8.16e-02	0.41800	3.72e-01	-0.192000	6.33e-03	1.58e-01
Metabolism-of-Angiotensinogen-to-Angiotensins	12	2.00e-02	8.22e-02	0.60400	4.15e-01	-0.439000	1.28e-02	8.44e-03
Defective-GALNT3-causes-familial-hyperphosphatemic-tumoral-calcinosis-(HFTC)	12	2.02e-02	8.29e-02	0.55900	4.65e-01	-0.309000	5.24e-03	6.35e-02
Regulation-of-signaling-by-CBL	18	2.06e-02	8.40e-02	0.47800	-2.95e-01	0.376000	3.01e-02	5.77e-03
Class-I-MHC-mediated-antigen-processing-&-presentation	353	2.08e-02	8.48e-02	0.04850	-3.10e-02	-0.037300	3.16e-01	2.28e-01
Establishment-of-Sister-Chromatid-Cohesion	11	2.13e-02	8.63e-02	0.29200	-1.05e-01	-0.272000	5.46e-01	1.18e-01
Prolactin-receptor-signaling	10	2.13e-02	8.64e-02	0.38000	-3.80e-01	0.015500	3.76e-02	9.32e-01
Acetylcholine-Neurotransmitter-Release-Cycle	14	2.15e-02	8.70e-02	0.51500	4.28e-01	-0.288000	5.60e-03	6.24e-02
Regulation-of-PTEN-gene-transcription	59	2.17e-02	8.75e-02	0.25200	-1.42e-01	0.208000	5.85e-02	5.65e-03
Vesicle-mediated-transport	625	2.18e-02	8.75e-02	0.07180	6.33e-02	-0.034000	6.70e-03	1.46e-01
Aberrant-regulation-of-mitotic-G1/S-transition-in-cancer-due-to-RB1-defects	17	2.20e-02	8.79e-02	0.36900	3.50e-01	-0.119000	1.25e-02	3.97e-01
Defective-binding-of-RB1-mutants-to-E2F1,(E2F2,-E2F3)	17	2.20e-02	8.79e-02	0.36900	3.50e-01	-0.119000	1.25e-02	3.97e-01
TRAF6-mediated-NF-kB-activation	21	2.22e-02	8.83e-02	0.44900	3.02e-01	-0.333000	1.66e-02	8.30e-03
TRP-channels	24	2.23e-02	8.86e-02	0.30900	2.93e-01	-0.097400	1.30e-02	4.09e-01
Phase-2—plateau-phase	15	2.28e-02	9.03e-02	0.23100	1.80e-01	0.145000	2.28e-01	3.29e-01
Passive-transport-by-Aquaporins	11	2.29e-02	9.03e-02	0.58300	4.78e-01	-0.334000	6.01e-03	5.52e-02
Senescence-Associated-Secretory-Phenotype-(SASP)	48	2.29e-02	9.03e-02	0.29100	2.25e-01	-0.185000	6.93e-03	2.65e-02
Glutathione-synthesis-and-recycling	12	2.30e-02	9.03e-02	0.56200	-4.58e-01	0.327000	6.05e-03	4.99e-02
Translesion-synthesis-by-POLK	16	2.37e-02	9.27e-02	0.42100	3.80e-01	-0.181000	8.48e-03	2.09e-01
Golgi-Associated-Vesicle-Biogenesis	55	2.37e-02	9.27e-02	0.25300	1.37e-01	-0.213000	7.82e-02	6.30e-03
TBC/RABGAPs	43	2.38e-02	9.30e-02	0.30500	2.38e-01	-0.192000	7.02e-03	2.97e-02
TP53-Regulates-Transcription-of-DNA-Repair-Genes	57	2.45e-02	9.51e-02	0.16500	1.64e-01	-0.017900	3.24e-02	8.15e-01
Integration-of-energy-metabolism	104	2.57e-02	9.95e-02	0.09320	8.76e-02	0.031900	1.22e-01	5.74e-01
Zinc-transporters	17	2.57e-02	9.95e-02	0.22700	-8.74e-02	-0.209000	5.33e-01	1.36e-01
Gamma-carboxylation,-hypusine-formation-and-arylsulfatase-activation	37	2.60e-02	1.01e-01	0.26300	-1.04e-01	0.242000	2.75e-01	1.08e-02
PI-Metabolism	82	2.61e-02	1.01e-01	0.10300	3.88e-02	0.095900	5.43e-01	1.33e-01
Recognition-of-DNA-damage-by-PCNA-containing-replication-complex	29	2.63e-02	1.01e-01	0.35000	2.89e-01	-0.197000	6.99e-03	6.63e-02
RNA-Polymerase-I-Transcription-Initiation	44	2.64e-02	1.01e-01	0.26800	-1.34e-01	0.232000	1.24e-01	7.64e-03
Toll-like-Receptor-Cascades	143	2.66e-02	1.01e-01	0.15200	7.89e-02	-0.130000	1.03e-01	7.37e-03
Signaling-by-NOTCH4	79	2.66e-02	1.01e-01	0.12500	-3.56e-03	-0.125000	9.56e-01	5.41e-02
Transport-of-bile-salts-and-organic-acids,-metal-ions-and-amine-compounds	80	2.72e-02	1.04e-01	0.22000	1.39e-01	-0.171000	3.21e-02	8.16e-03
RNA-Polymerase-II-Transcription-Termination	62	2.73e-02	1.04e-01	0.18100	-1.74e-01	0.051400	1.79e-02	4.84e-01
Pyruvate-metabolism	28	2.74e-02	1.04e-01	0.31100	1.32e-01	-0.281000	2.25e-01	1.00e-02
Phase-0—rapid-depolarisation	29	2.75e-02	1.04e-01	0.22600	2.25e-01	-0.023000	3.62e-02	8.30e-01
NOTCH4-Intracellular-Domain-Regulates-Transcription	20	2.79e-02	1.05e-01	0.42000	-2.40e-01	0.345000	6.34e-02	7.48e-03
Activation-of-gene-expression-by-SREBF-(SREBP)	40	2.81e-02	1.06e-01	0.16900	-1.31e-02	-0.169000	8.86e-01	6.47e-02
Signaling-by-FGFR4-in-disease	11	2.85e-02	1.06e-01	0.43000	1.25e-01	-0.412000	4.72e-01	1.80e-02
RAF/MAP-kinase-cascade	263	2.90e-02	1.08e-01	0.07340	5.72e-03	-0.073200	8.73e-01	4.08e-02
Deubiquitination	232	2.91e-02	1.08e-01	0.09080	2.33e-02	-0.087800	5.41e-01	2.11e-02
CREB1-phosphorylation-through-NMDA-receptor-mediated-activation-of-RAS-signaling	28	2.93e-02	1.09e-01	0.35300	2.90e-01	-0.202000	7.88e-03	6.46e-02
RNA-Polymerase-I-Transcription	48	2.98e-02	1.11e-01	0.24700	-1.18e-01	0.217000	1.57e-01	9.25e-03
Scavenging-of-heme-from-plasma	23	3.02e-02	1.12e-01	0.33400	-3.04e-01	0.138000	1.16e-02	2.50e-01
Synthesis,-secretion,-and-inactivation-of-Glucagon-like-Peptide-1-(GLP-1)	15	3.03e-02	1.12e-01	0.27300	-2.20e-02	-0.272000	8.83e-01	6.82e-02
Interleukin-receptor-SHC-signaling	25	3.03e-02	1.12e-01	0.36100	-1.93e-01	0.305000	9.41e-02	8.35e-03
Cell-surface-interactions-at-the-vascular-wall	126	3.05e-02	1.12e-01	0.11200	-1.84e-02	0.111000	7.22e-01	3.14e-02
Glucagon-like-Peptide-1-(GLP1)-regulates-insulin-secretion	39	3.10e-02	1.13e-01	0.21700	2.10e-01	-0.053300	2.32e-02	5.65e-01
MET-activates-PTK2-signaling	18	3.18e-02	1.16e-01	0.27800	-2.50e-02	0.277000	8.55e-01	4.18e-02
Signaling-by-FGFR-in-disease	57	3.22e-02	1.17e-01	0.16900	3.17e-02	-0.166000	6.79e-01	3.00e-02
Apoptotic-factor-mediated-response	15	3.24e-02	1.18e-01	0.23400	8.88e-02	0.216000	5.51e-01	1.47e-01
G2/M-Checkpoints	130	3.36e-02	1.22e-01	0.15600	8.27e-02	-0.132000	1.03e-01	9.40e-03
Transcription-Coupled-Nucleotide-Excision-Repair-(TC-NER)	77	3.37e-02	1.22e-01	0.13400	1.33e-01	-0.012000	4.36e-02	8.56e-01
Cholesterol-biosynthesis	23	3.37e-02	1.22e-01	0.35000	1.67e-01	-0.308000	1.64e-01	1.06e-02
Organelle-biogenesis-and-maintenance	247	3.38e-02	1.22e-01	0.11100	-5.76e-02	0.095400	1.19e-01	9.69e-03
Homologous-DNA-Pairing-and-Strand-Exchange	42	3.43e-02	1.23e-01	0.14300	1.36e-01	0.043800	1.28e-01	6.23e-01
HIV-elongation-arrest-and-recovery	29	3.43e-02	1.23e-01	0.32700	2.78e-01	-0.173000	9.66e-03	1.08e-01
Pausing-and-recovery-of-HIV-elongation	29	3.43e-02	1.23e-01	0.32700	2.78e-01	-0.173000	9.66e-03	1.08e-01
Processing-of-Capped-Intronless-Pre-mRNA	25	3.47e-02	1.23e-01	0.26800	-2.59e-01	0.067900	2.49e-02	5.57e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G2-Cell-Cycle-Arrest	18	3.47e-02	1.23e-01	0.33100	3.15e-01	-0.100000	2.06e-02	4.63e-01
FCERI-mediated-Ca+2-mobilization	39	3.51e-02	1.24e-01	0.31000	-2.09e-01	0.228000	2.38e-02	1.36e-02
Defective-pyroptosis	13	3.52e-02	1.25e-01	0.53400	-3.98e-01	0.356000	1.30e-02	2.61e-02
Assembly-Of-The-HIV-Virion	14	3.56e-02	1.26e-01	0.48600	2.78e-01	-0.399000	7.22e-02	9.81e-03
Sodium/Calcium-exchangers	10	3.58e-02	1.26e-01	0.51000	4.57e-01	-0.227000	1.24e-02	2.14e-01
DNA-Double-Strand-Break-Repair	129	3.59e-02	1.26e-01	0.07470	4.30e-02	0.061100	3.98e-01	2.31e-01
Assembly-of-active-LPL-and-LIPC-lipase-complexes	18	3.59e-02	1.26e-01	0.35100	1.29e-01	-0.326000	3.43e-01	1.65e-02
EPH-Ephrin-signaling	85	3.60e-02	1.26e-01	0.18400	1.60e-01	-0.090800	1.09e-02	1.48e-01
Signaling-by-ERBB2-KD-Mutants	24	3.62e-02	1.26e-01	0.23400	1.81e-02	-0.233000	8.78e-01	4.77e-02
Epigenetic-regulation-of-gene-expression	85	3.65e-02	1.27e-01	0.20900	-1.41e-01	0.154000	2.50e-02	1.41e-02
ATF6-(ATF6-alpha)-activates-chaperone-genes	10	3.66e-02	1.27e-01	0.48200	-4.43e-01	0.190000	1.52e-02	2.98e-01
APC/C:Cdc20-mediated-degradation-of-Cyclin-B	23	3.67e-02	1.27e-01	0.40100	2.73e-01	-0.293000	2.34e-02	1.49e-02
DNA-Repair	276	3.68e-02	1.27e-01	0.05190	4.50e-02	0.025800	1.98e-01	4.60e-01
Synthesis-of-active-ubiquitin:-roles-of-E1-and-E2-enzymes	29	3.71e-02	1.28e-01	0.22000	2.67e-02	-0.218000	8.03e-01	4.21e-02
Signaling-by-TGFB-family-members	98	3.73e-02	1.28e-01	0.11400	6.26e-03	-0.113000	9.15e-01	5.22e-02
Dermatan-sulfate-biosynthesis	10	3.78e-02	1.30e-01	0.51300	-2.35e-01	0.455000	1.97e-01	1.26e-02
Toll-Like-Receptor-4-(TLR4)-Cascade	124	3.81e-02	1.30e-01	0.15800	8.63e-02	-0.133000	9.67e-02	1.07e-02
Deregulated-CDK5-triggers-multiple-neurodegenerative-pathways-in-Alzheimer’s-disease-models	22	3.81e-02	1.30e-01	0.40700	3.00e-01	-0.274000	1.47e-02	2.60e-02
Neurodegenerative-Diseases	22	3.81e-02	1.30e-01	0.40700	3.00e-01	-0.274000	1.47e-02	2.60e-02
Sema3A-PAK-dependent-Axon-repulsion	16	3.82e-02	1.30e-01	0.26200	1.06e-02	0.262000	9.42e-01	6.99e-02
Cyclin-A/B1/B2-associated-events-during-G2/M-transition	24	3.83e-02	1.30e-01	0.36000	3.01e-01	-0.198000	1.07e-02	9.32e-02
Apoptotic-execution-phase	44	3.90e-02	1.32e-01	0.15000	1.49e-01	0.017700	8.69e-02	8.39e-01
Interleukin-27-signaling	11	3.97e-02	1.34e-01	0.50400	-4.37e-01	0.250000	1.20e-02	1.51e-01
RHO-GTPases-Activate-WASPs-and-WAVEs	35	3.99e-02	1.34e-01	0.28300	1.41e-01	-0.245000	1.48e-01	1.20e-02
Defective-C1GALT1C1-causes-Tn-polyagglutination-syndrome-(TNPS)	13	4.01e-02	1.34e-01	0.52700	3.67e-01	-0.378000	2.20e-02	1.81e-02
Na+/Cl–dependent-neurotransmitter-transporters	18	4.01e-02	1.34e-01	0.43300	2.64e-01	-0.343000	5.26e-02	1.18e-02
Golgi-to-ER-retrograde-transport	109	4.02e-02	1.34e-01	0.13200	1.25e-01	-0.039800	2.35e-02	4.72e-01
G-alpha-(12/13)-signalling-events	77	4.08e-02	1.36e-01	0.10400	2.97e-02	0.099200	6.52e-01	1.32e-01
RHO-GTPases-Activate-ROCKs	18	4.10e-02	1.36e-01	0.40200	3.43e-01	-0.211000	1.18e-02	1.21e-01
mRNA-3’-end-processing	54	4.12e-02	1.37e-01	0.18800	-1.79e-01	0.059400	2.30e-02	4.50e-01
Interleukin-12-signaling	44	4.17e-02	1.38e-01	0.12900	-5.74e-02	-0.115000	5.10e-01	1.86e-01
Sensory-processing-of-sound	69	4.17e-02	1.38e-01	0.17600	1.63e-01	-0.064900	1.90e-02	3.51e-01
COPI-mediated-anterograde-transport	80	4.18e-02	1.38e-01	0.11200	1.11e-01	0.010800	8.57e-02	8.67e-01
Processing-of-Intronless-Pre-mRNAs	17	4.21e-02	1.38e-01	0.33100	-3.16e-01	0.101000	2.43e-02	4.70e-01
Glutamate-binding,-activation-of-AMPA-receptors-and-synaptic-plasticity	30	4.22e-02	1.38e-01	0.15300	1.33e-01	0.076900	2.09e-01	4.66e-01
Trafficking-of-AMPA-receptors	30	4.22e-02	1.38e-01	0.15300	1.33e-01	0.076900	2.09e-01	4.66e-01
DAG-and-IP3-signaling	39	4.24e-02	1.39e-01	0.14200	4.66e-02	0.134000	6.14e-01	1.47e-01
Interleukin-35-Signalling	12	4.29e-02	1.40e-01	0.52100	-4.16e-01	0.314000	1.25e-02	5.98e-02
Base-Excision-Repair	45	4.34e-02	1.41e-01	0.14000	1.37e-01	0.028200	1.13e-01	7.44e-01
DAP12-interactions	33	4.40e-02	1.43e-01	0.29800	-1.60e-01	0.251000	1.11e-01	1.26e-02
TICAM1,TRAF6-dependent-induction-of-TAK1-complex	10	4.43e-02	1.44e-01	0.58300	3.76e-01	-0.445000	3.97e-02	1.47e-02
Bile-acid-and-bile-salt-metabolism	39	4.46e-02	1.44e-01	0.21500	6.44e-02	-0.206000	4.86e-01	2.63e-02
Pausing-and-recovery-of-Tat-mediated-HIV-elongation	27	4.46e-02	1.44e-01	0.30700	2.71e-01	-0.144000	1.46e-02	1.94e-01
Tat-mediated-HIV-elongation-arrest-and-recovery	27	4.46e-02	1.44e-01	0.30700	2.71e-01	-0.144000	1.46e-02	1.94e-01
Signaling-by-EGFR-in-Cancer	23	4.49e-02	1.44e-01	0.22800	1.38e-02	-0.228000	9.09e-01	5.84e-02
RND2-GTPase-cycle	42	4.51e-02	1.44e-01	0.21000	-6.59e-02	0.200000	4.60e-01	2.52e-02
RHOD-GTPase-cycle	53	4.53e-02	1.44e-01	0.22000	-1.04e-01	0.194000	1.89e-01	1.47e-02
RNA-Polymerase-III-Transcription-Initiation-From-Type-3-Promoter	28	4.53e-02	1.44e-01	0.28400	1.17e-01	-0.259000	2.84e-01	1.78e-02
MyD88:MAL(TIRAP)-cascade-initiated-on-plasma-membrane	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Toll-Like-Receptor-2-(TLR2)-Cascade	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Toll-Like-Receptor-TLR1:TLR2-Cascade	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Toll-Like-Receptor-TLR6:TLR2-Cascade	95	4.55e-02	1.44e-01	0.19100	1.30e-01	-0.140000	2.81e-02	1.87e-02
Long-term-potentiation	23	4.59e-02	1.45e-01	0.29200	2.74e-01	-0.101000	2.28e-02	4.02e-01
Diseases-of-metabolism	222	4.60e-02	1.45e-01	0.08620	-2.17e-02	0.083400	5.78e-01	3.20e-02
RNA-Polymerase-I-Promoter-Clearance	47	4.65e-02	1.46e-01	0.23500	-1.14e-01	0.205000	1.77e-01	1.48e-02
Clathrin-mediated-endocytosis	134	4.68e-02	1.47e-01	0.15700	9.88e-02	-0.122000	4.82e-02	1.47e-02
Metal-ion-SLC-transporters	26	4.68e-02	1.47e-01	0.22100	2.41e-02	-0.220000	8.32e-01	5.21e-02
TP53-Regulates-Transcription-of-Cell-Cycle-Genes	46	4.69e-02	1.47e-01	0.21700	1.99e-01	-0.085600	1.95e-02	3.15e-01
N-Glycan-antennae-elongation	14	4.76e-02	1.49e-01	0.37900	3.53e-01	-0.138000	2.21e-02	3.71e-01
Iron-uptake-and-transport	55	4.77e-02	1.49e-01	0.23100	1.92e-01	-0.128000	1.37e-02	1.00e-01
Incretin-synthesis,-secretion,-and-inactivation	17	4.81e-02	1.49e-01	0.21900	-5.22e-02	-0.213000	7.09e-01	1.28e-01
Regulation-of-cholesterol-biosynthesis-by-SREBP-(SREBF)	53	4.81e-02	1.49e-01	0.15200	1.29e-02	-0.151000	8.71e-01	5.69e-02
Downregulation-of-ERBB2-signaling	27	4.91e-02	1.52e-01	0.19100	-1.13e-02	-0.191000	9.19e-01	8.57e-02
Adherens-junctions-interactions	23	4.94e-02	1.52e-01	0.25500	-5.42e-02	0.249000	6.53e-01	3.89e-02
Formation-of-the-Early-Elongation-Complex	33	5.02e-02	1.54e-01	0.14400	6.41e-02	0.129000	5.24e-01	1.99e-01
Formation-of-the-HIV-1-Early-Elongation-Complex	33	5.02e-02	1.54e-01	0.14400	6.41e-02	0.129000	5.24e-01	1.99e-01
Trafficking-of-GluR2-containing-AMPA-receptors	17	5.04e-02	1.55e-01	0.19900	1.75e-01	0.094200	2.10e-01	5.01e-01
Cooperation-of-Prefoldin-and-TriC/CCT–in-actin-and-tubulin-folding	27	5.05e-02	1.55e-01	0.16100	-1.46e-01	-0.066800	1.88e-01	5.48e-01
ERCC6-(CSB)-and-EHMT2-(G9a)-positively-regulate-rRNA-expression	16	5.06e-02	1.55e-01	0.42300	-2.34e-01	0.353000	1.05e-01	1.46e-02
Transcriptional-regulation-by-RUNX2	114	5.09e-02	1.55e-01	0.14400	6.58e-02	-0.129000	2.25e-01	1.76e-02
Activation-of-the-TFAP2-(AP-2)-family-of-transcription-factors	10	5.10e-02	1.55e-01	0.43800	4.10e-01	-0.154000	2.47e-02	4.00e-01
Ras-activation-upon-Ca2+-influx-through-NMDA-receptor	20	5.11e-02	1.55e-01	0.39000	3.14e-01	-0.231000	1.50e-02	7.36e-02
G1/S-Transition	127	5.15e-02	1.56e-01	0.14200	7.06e-02	-0.124000	1.69e-01	1.61e-02
Toll-Like-Receptor-7/8-(TLR7/8)-Cascade	86	5.15e-02	1.56e-01	0.19400	1.26e-01	-0.148000	4.39e-02	1.75e-02
Antigen-processing:-Ubiquitination-&-Proteasome-degradation	295	5.24e-02	1.58e-01	0.04690	-2.57e-02	-0.039200	4.47e-01	2.46e-01
Autophagy	125	5.26e-02	1.58e-01	0.16100	1.22e-01	-0.106000	1.85e-02	4.12e-02
Protein-ubiquitination	60	5.28e-02	1.59e-01	0.11300	-1.09e-01	-0.031200	1.46e-01	6.75e-01
Adrenaline,noradrenaline-inhibits-insulin-secretion	27	5.38e-02	1.61e-01	0.21900	2.16e-01	-0.031800	5.17e-02	7.75e-01
Mitotic-G1-phase-and-G1/S-transition	144	5.38e-02	1.61e-01	0.14000	7.75e-02	-0.117000	1.08e-01	1.57e-02
MAPK1/MAPK3-signaling	269	5.46e-02	1.63e-01	0.06200	-2.83e-04	-0.062000	9.94e-01	7.97e-02
Role-of-LAT2/NTAL/LAB-on-calcium-mobilization	24	5.47e-02	1.63e-01	0.34700	-2.84e-01	0.199000	1.60e-02	9.13e-02
Synthesis-of-very-long-chain-fatty-acyl-CoAs	21	5.50e-02	1.64e-01	0.36900	2.09e-01	-0.304000	9.73e-02	1.60e-02
Netrin-1-signaling	48	5.52e-02	1.64e-01	0.20600	-8.06e-02	0.189000	3.34e-01	2.33e-02
Signaling-by-BMP	26	5.55e-02	1.64e-01	0.15700	-7.93e-02	-0.136000	4.84e-01	2.31e-01
Mitophagy	28	5.65e-02	1.67e-01	0.30000	1.51e-01	-0.259000	1.66e-01	1.76e-02
Translesion-synthesis-by-REV1	15	5.68e-02	1.68e-01	0.42100	3.56e-01	-0.225000	1.69e-02	1.32e-01
RIPK1-mediated-regulated-necrosis	26	5.72e-02	1.68e-01	0.29500	1.33e-01	-0.263000	2.42e-01	2.02e-02
Regulation-of-necroptotic-cell-death	26	5.72e-02	1.68e-01	0.29500	1.33e-01	-0.263000	2.42e-01	2.02e-02
Formation-of-tubulin-folding-intermediates-by-CCT/TriC	20	5.73e-02	1.68e-01	0.28900	-2.76e-01	0.087100	3.28e-02	5.00e-01
Regulation-of-FOXO-transcriptional-activity-by-acetylation	10	5.92e-02	1.73e-01	0.36200	6.31e-02	-0.356000	7.30e-01	5.10e-02
Sensory-processing-of-sound-by-inner-hair-cells-of-the-cochlea	63	5.94e-02	1.74e-01	0.15000	1.46e-01	-0.033000	4.44e-02	6.51e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-GG-NER	24	5.95e-02	1.74e-01	0.20700	2.07e-01	-0.004800	7.85e-02	9.68e-01
rRNA-modification-in-the-nucleus-and-cytosol	58	5.98e-02	1.74e-01	0.10300	-8.49e-02	-0.057600	2.63e-01	4.47e-01
Unblocking-of-NMDA-receptors,-glutamate-binding-and-activation	21	6.01e-02	1.74e-01	0.31000	2.84e-01	-0.125000	2.45e-02	3.21e-01
Factors-involved-in-megakaryocyte-development-and-platelet-production	112	6.03e-02	1.74e-01	0.08110	2.18e-02	0.078100	6.89e-01	1.53e-01
Cargo-concentration-in-the-ER	33	6.07e-02	1.74e-01	0.13700	-1.18e-01	-0.070300	2.42e-01	4.85e-01
APC-truncation-mutants-have-impaired-AXIN-binding	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
AXIN-missense-mutants-destabilize-the-destruction-complex	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Signaling-by-AMER1-mutants	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Signaling-by-APC-mutants	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Signaling-by-AXIN-mutants	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Truncations-of-AMER1-destabilize-the-destruction-complex	14	6.08e-02	1.74e-01	0.32500	3.15e-01	-0.081200	4.11e-02	5.99e-01
Apoptotic-cleavage-of-cell-adhesion–proteins	10	6.09e-02	1.74e-01	0.34600	3.43e-01	-0.044100	6.00e-02	8.09e-01
ERBB2-Regulates-Cell-Motility	14	6.13e-02	1.75e-01	0.32500	8.05e-02	-0.314000	6.02e-01	4.16e-02
Growth-hormone-receptor-signaling	19	6.19e-02	1.76e-01	0.20400	-3.75e-02	-0.201000	7.77e-01	1.30e-01
PLC-beta-mediated-events	47	6.19e-02	1.76e-01	0.13700	1.12e-02	0.137000	8.94e-01	1.04e-01
HDR-through-Homologous-Recombination-(HRR)	65	6.23e-02	1.77e-01	0.14000	1.38e-01	-0.023000	5.47e-02	7.49e-01
Glucagon-signaling-in-metabolic-regulation	30	6.25e-02	1.77e-01	0.22500	-5.99e-02	0.217000	5.70e-01	3.99e-02
RAC3-GTPase-cycle	90	6.29e-02	1.78e-01	0.17300	-9.73e-02	0.143000	1.10e-01	1.87e-02
Deactivation-of-the-beta-catenin-transactivating-complex	38	6.35e-02	1.79e-01	0.25100	-1.26e-01	0.218000	1.80e-01	2.02e-02
Aspartate-and-asparagine-metabolism	11	6.37e-02	1.79e-01	0.48300	2.59e-01	-0.408000	1.37e-01	1.92e-02
Sphingolipid-de-novo-biosynthesis	42	6.41e-02	1.80e-01	0.11700	-8.18e-02	-0.084200	3.59e-01	3.45e-01
RAC1-GTPase-cycle	180	6.45e-02	1.81e-01	0.11000	-4.92e-02	0.098000	2.55e-01	2.31e-02
Regulation-of-TLR-by-endogenous-ligand	16	6.47e-02	1.81e-01	0.42300	2.57e-01	-0.336000	7.48e-02	2.01e-02
MAP3K8-(TPL2)-dependent-MAPK1/3-activation	15	6.54e-02	1.83e-01	0.33500	1.10e-01	-0.316000	4.61e-01	3.40e-02
Membrane-binding-and-targetting-of-GAG-proteins	12	6.65e-02	1.85e-01	0.46700	2.59e-01	-0.388000	1.20e-01	1.99e-02
Synthesis-And-Processing-Of-GAG,-GAGPOL-Polyproteins	12	6.65e-02	1.85e-01	0.46700	2.59e-01	-0.388000	1.20e-01	1.99e-02
Association-of-TriC/CCT-with-target-proteins-during-biosynthesis	37	6.66e-02	1.85e-01	0.12800	-1.11e-01	-0.063800	2.44e-01	5.01e-01
Class-I-peroxisomal-membrane-protein-import	20	6.67e-02	1.85e-01	0.24600	3.74e-02	-0.243000	7.72e-01	5.99e-02
mRNA-Splicing	185	6.73e-02	1.86e-01	0.06310	-1.46e-02	-0.061300	7.32e-01	1.50e-01
Inflammasomes	21	6.76e-02	1.87e-01	0.34400	-1.83e-01	0.292000	1.47e-01	2.07e-02
NOD1/2-Signaling-Pathway	30	6.81e-02	1.88e-01	0.13800	-8.70e-02	-0.107000	4.09e-01	3.11e-01
PIWI-interacting-RNA-(piRNA)-biogenesis	27	6.83e-02	1.88e-01	0.32700	2.54e-01	-0.206000	2.24e-02	6.41e-02
Dopamine-Neurotransmitter-Release-Cycle	23	6.85e-02	1.88e-01	0.27100	2.55e-01	-0.092400	3.42e-02	4.43e-01
Intra-Golgi-and-retrograde-Golgi-to-ER-traffic	173	6.88e-02	1.88e-01	0.10900	9.80e-02	-0.047000	2.60e-02	2.86e-01
Sealing-of-the-nuclear-envelope-(NE)-by-ESCRT-III	24	6.89e-02	1.88e-01	0.16100	1.45e-01	0.069300	2.19e-01	5.57e-01
MAPK-family-signaling-cascades	306	6.98e-02	1.91e-01	0.05410	-2.56e-03	-0.054000	9.39e-01	1.03e-01
G-alpha-(s)-signalling-events	117	7.00e-02	1.91e-01	0.08820	2.53e-03	0.088200	9.62e-01	9.92e-02
MET-receptor-recycling	10	7.04e-02	1.91e-01	0.39900	-3.79e-01	0.126000	3.80e-02	4.89e-01
SMAD2/SMAD3:SMAD4-heterotrimer-regulates-transcription	31	7.05e-02	1.91e-01	0.14400	-1.35e-01	-0.051600	1.94e-01	6.19e-01
Innate-Immune-System	899	7.08e-02	1.91e-01	0.05810	3.87e-02	-0.043300	4.80e-02	2.70e-02
Recycling-pathway-of-L1	27	7.08e-02	1.91e-01	0.15700	1.49e-01	0.049600	1.80e-01	6.56e-01
MyD88-dependent-cascade-initiated-on-endosome	85	7.09e-02	1.91e-01	0.18500	1.20e-01	-0.141000	5.62e-02	2.49e-02
Aberrant-regulation-of-mitotic-cell-cycle-due-to-RB1-defects	36	7.21e-02	1.94e-01	0.24700	2.17e-01	-0.119000	2.42e-02	2.17e-01
CaM-pathway	33	7.22e-02	1.94e-01	0.19600	-3.90e-02	0.192000	6.98e-01	5.58e-02
Calmodulin-induced-events	33	7.22e-02	1.94e-01	0.19600	-3.90e-02	0.192000	6.98e-01	5.58e-02
Presynaptic-phase-of-homologous-DNA-pairing-and-strand-exchange	39	7.23e-02	1.94e-01	0.14500	1.44e-01	0.015000	1.20e-01	8.71e-01
PCNA-Dependent-Long-Patch-Base-Excision-Repair	21	7.36e-02	1.97e-01	0.22700	2.26e-01	-0.024600	7.30e-02	8.45e-01
Regulation-of-TP53-Degradation	33	7.42e-02	1.98e-01	0.29800	2.09e-01	-0.212000	3.78e-02	3.49e-02
Synthesis-of-IP2,-IP,-and-Ins-in-the-cytosol	14	7.43e-02	1.98e-01	0.22400	5.27e-02	0.218000	7.33e-01	1.59e-01
eNOS-activation	11	7.46e-02	1.98e-01	0.41500	-3.78e-01	0.171000	2.99e-02	3.25e-01
Apoptotic-cleavage-of-cellular-proteins	37	7.47e-02	1.98e-01	0.14700	1.46e-01	0.016500	1.24e-01	8.62e-01
Synthesis-of-bile-acids-and-bile-salts-via-7alpha-hydroxycholesterol	21	7.52e-02	1.98e-01	0.21300	6.25e-03	-0.213000	9.60e-01	9.07e-02
Vitamin-B5-(pantothenate)-metabolism	16	7.53e-02	1.98e-01	0.19200	-1.72e-01	-0.086100	2.33e-01	5.51e-01
Diseases-of-mitotic-cell-cycle	38	7.53e-02	1.98e-01	0.24100	2.10e-01	-0.118000	2.49e-02	2.08e-01
Chromatin-modifying-enzymes	198	7.55e-02	1.98e-01	0.12000	-9.06e-02	0.079200	2.78e-02	5.45e-02
Chromatin-organization	198	7.55e-02	1.98e-01	0.12000	-9.06e-02	0.079200	2.78e-02	5.45e-02
Regulation-of-TP53-Activity	153	7.57e-02	1.98e-01	0.09270	9.03e-02	-0.020900	5.37e-02	6.56e-01
Peptide-hormone-metabolism	69	7.58e-02	1.98e-01	0.20400	1.35e-01	-0.152000	5.18e-02	2.87e-02
MyD88-cascade-initiated-on-plasma-membrane	78	7.59e-02	1.98e-01	0.19300	1.33e-01	-0.139000	4.19e-02	3.33e-02
Toll-Like-Receptor-10-(TLR10)-Cascade	78	7.59e-02	1.98e-01	0.19300	1.33e-01	-0.139000	4.19e-02	3.33e-02
Toll-Like-Receptor-5-(TLR5)-Cascade	78	7.59e-02	1.98e-01	0.19300	1.33e-01	-0.139000	4.19e-02	3.33e-02
ER-Quality-Control-Compartment-(ERQC)	19	7.63e-02	1.98e-01	0.30900	-2.84e-01	0.122000	3.22e-02	3.56e-01
Resolution-of-D-loop-Structures-through-Synthesis-Dependent-Strand-Annealing-(SDSA)	26	7.63e-02	1.98e-01	0.15400	1.43e-01	0.058300	2.08e-01	6.07e-01
Class-A/1-(Rhodopsin-like-receptors)	254	7.64e-02	1.98e-01	0.06140	-1.82e-03	0.061400	9.60e-01	9.16e-02
Nuclear-Receptor-transcription-pathway	51	7.66e-02	1.98e-01	0.18600	-1.72e-01	0.071100	3.36e-02	3.80e-01
Lagging-Strand-Synthesis	20	7.73e-02	2.00e-01	0.16400	1.16e-01	0.116000	3.68e-01	3.70e-01
Gap-filling-DNA-repair-synthesis-and-ligation-in-TC-NER	63	7.76e-02	2.00e-01	0.09760	8.90e-02	0.040100	2.22e-01	5.82e-01
Gene-and-protein-expression-by-JAK-STAT-signaling-after-Interleukin-12-stimulation	35	7.78e-02	2.00e-01	0.19400	4.61e-02	-0.189000	6.37e-01	5.30e-02
Deadenylation-dependent-mRNA-decay	54	7.82e-02	2.01e-01	0.12400	-1.23e-01	-0.008850	1.17e-01	9.10e-01
Macroautophagy	111	7.82e-02	2.01e-01	0.15800	1.22e-01	-0.100000	2.67e-02	6.73e-02
RHOG-GTPase-cycle	72	7.89e-02	2.02e-01	0.17300	-8.47e-02	0.151000	2.14e-01	2.63e-02
Signaling-by-CSF3-(G-CSF)	27	7.91e-02	2.02e-01	0.14400	-1.23e-01	-0.074500	2.67e-01	5.03e-01
Downregulation-of-SMAD2/3:SMAD4-transcriptional-activity	22	8.03e-02	2.05e-01	0.18600	-1.84e-01	-0.024500	1.35e-01	8.42e-01
Adaptive-Immune-System	672	8.06e-02	2.06e-01	0.06460	-4.95e-02	0.041500	2.81e-02	6.55e-02
Synthesis-of-bile-acids-and-bile-salts	31	8.13e-02	2.07e-01	0.23000	8.25e-02	-0.215000	4.27e-01	3.83e-02
Gamma-carboxylation-of-protein-precursors	10	8.13e-02	2.07e-01	0.36700	-9.38e-02	0.354000	6.07e-01	5.22e-02
NOTCH2-intracellular-domain-regulates-transcription	11	8.14e-02	2.07e-01	0.49800	-3.21e-01	0.381000	6.50e-02	2.86e-02
HCMV-Late-Events	52	8.19e-02	2.07e-01	0.19800	1.75e-01	-0.092600	2.87e-02	2.48e-01
Downstream-signal-transduction	29	8.25e-02	2.09e-01	0.30900	-2.06e-01	0.230000	5.48e-02	3.19e-02
Opioid-Signalling	84	8.30e-02	2.10e-01	0.08260	7.41e-02	0.036500	2.40e-01	5.63e-01
Regulation-of-MECP2-expression-and-activity	28	8.36e-02	2.11e-01	0.31100	-2.38e-01	0.200000	2.94e-02	6.67e-02
Interleukin-12-family-signaling	54	8.38e-02	2.11e-01	0.09950	-8.12e-02	-0.057500	3.02e-01	4.65e-01
APC-Cdc20-mediated-degradation-of-Nek2A	25	8.47e-02	2.13e-01	0.33200	2.44e-01	-0.224000	3.43e-02	5.21e-02
Degradation-of-the-extracellular-matrix	99	8.49e-02	2.13e-01	0.11100	-2.31e-02	0.108000	6.91e-01	6.21e-02
Keratan-sulfate-degradation	10	8.60e-02	2.15e-01	0.52200	-3.50e-01	0.388000	5.54e-02	3.38e-02
Synthesis-of-PA	34	8.60e-02	2.15e-01	0.27800	2.16e-01	-0.175000	2.90e-02	7.76e-02
Signaling-by-FLT3-fusion-proteins	19	8.65e-02	2.15e-01	0.22800	2.03e-02	-0.227000	8.78e-01	8.65e-02
Signaling-by-FGFR2-in-disease	38	8.65e-02	2.15e-01	0.25400	1.47e-01	-0.207000	1.17e-01	2.70e-02
Signaling-by-Leptin	10	8.67e-02	2.15e-01	0.42400	1.76e-01	-0.385000	3.35e-01	3.48e-02
PI3K-events-in-ERBB2-signaling	16	8.69e-02	2.15e-01	0.24500	1.80e-02	-0.245000	9.01e-01	9.02e-02
Nef-mediates-down-modulation-of-cell-surface-receptors-by-recruiting-them-to-clathrin-adapters	20	8.70e-02	2.15e-01	0.18900	3.00e-02	0.186000	8.17e-01	1.49e-01
IRAK2-mediated-activation-of-TAK1-complex-upon-TLR7/8-or-9-stimulation	14	8.70e-02	2.15e-01	0.38600	1.89e-01	-0.336000	2.21e-01	2.93e-02
Mismatch-repair-(MMR)-directed-by-MSH2:MSH3-(MutSbeta)	13	8.71e-02	2.15e-01	0.21600	2.04e-01	0.070600	2.02e-01	6.59e-01
Oncogenic-MAPK-signaling	79	8.72e-02	2.15e-01	0.16000	7.64e-02	-0.141000	2.40e-01	3.02e-02
Abortive-elongation-of-HIV-1-transcript-in-the-absence-of-Tat	23	8.86e-02	2.18e-01	0.19400	1.94e-01	-0.000422	1.08e-01	9.97e-01
Regulation-of-IFNA-signaling	12	8.88e-02	2.18e-01	0.42700	-2.22e-01	0.365000	1.83e-01	2.86e-02
Activation-of-Matrix-Metalloproteinases	25	8.97e-02	2.20e-01	0.23800	-7.19e-02	0.227000	5.33e-01	4.98e-02
Removal-of-aminoterminal-propeptides-from-gamma-carboxylated-proteins	10	9.01e-02	2.21e-01	0.30800	-2.34e-02	0.308000	8.98e-01	9.21e-02
TP53-Regulates-Metabolic-Genes	83	9.15e-02	2.24e-01	0.17000	9.78e-02	-0.139000	1.23e-01	2.88e-02
Regulation-of-BACH1-activity	10	9.18e-02	2.24e-01	0.23400	-1.04e-01	-0.210000	5.70e-01	2.50e-01
SUMOylation	166	9.21e-02	2.25e-01	0.12400	-9.72e-02	0.076400	3.05e-02	8.92e-02
The-NLRP3-inflammasome	16	9.31e-02	2.27e-01	0.32000	-1.24e-01	0.295000	3.92e-01	4.07e-02
Negative-regulators-of-DDX58/IFIH1-signaling	32	9.44e-02	2.29e-01	0.14500	-2.57e-02	-0.143000	8.02e-01	1.61e-01
Signaling-by-ERBB2	47	9.48e-02	2.30e-01	0.11700	-2.54e-02	-0.115000	7.63e-01	1.74e-01
Processing-of-Capped-Intron-Containing-Pre-mRNA	235	9.59e-02	2.32e-01	0.04650	-3.78e-02	-0.027100	3.17e-01	4.74e-01
Condensation-of-Prometaphase-Chromosomes	11	9.68e-02	2.34e-01	0.47400	3.73e-01	-0.293000	3.23e-02	9.26e-02
Telomere-C-strand-(Lagging-Strand)-Synthesis	34	9.70e-02	2.34e-01	0.13100	4.25e-02	0.124000	6.68e-01	2.12e-01
MASTL-Facilitates-Mitotic-Progression	10	9.71e-02	2.34e-01	0.50200	3.87e-01	-0.320000	3.41e-02	7.96e-02
Mismatch-repair-(MMR)-directed-by-MSH2:MSH6-(MutSalpha)	13	9.75e-02	2.35e-01	0.20900	1.95e-01	0.074800	2.24e-01	6.40e-01
Assembly-and-cell-surface-presentation-of-NMDA-receptors	25	9.83e-02	2.36e-01	0.14300	1.22e-01	0.074600	2.91e-01	5.18e-01
COPI-independent-Golgi-to-ER-retrograde-traffic	31	9.84e-02	2.36e-01	0.26100	2.22e-01	-0.136000	3.21e-02	1.91e-01
HDMs-demethylate-histones	23	9.89e-02	2.37e-01	0.15100	-1.34e-01	-0.070000	2.66e-01	5.61e-01
Phosphorylation-of-the-APC/C	20	9.91e-02	2.37e-01	0.36000	2.61e-01	-0.248000	4.33e-02	5.51e-02
Glucagon-type-ligand-receptors	28	1.01e-01	2.41e-01	0.13100	9.21e-02	0.093600	3.99e-01	3.91e-01
PKA-mediated-phosphorylation-of-CREB	19	1.02e-01	2.43e-01	0.25700	-6.93e-02	0.248000	6.01e-01	6.16e-02
Early-Phase-of-HIV-Life-Cycle	13	1.02e-01	2.43e-01	0.30100	2.93e-01	-0.071000	6.77e-02	6.57e-01
Signaling-by-ERBB2-ECD-mutants	15	1.02e-01	2.43e-01	0.18100	-1.06e-01	-0.146000	4.77e-01	3.27e-01
Diseases-of-DNA-repair	33	1.02e-01	2.43e-01	0.12700	1.15e-01	0.053200	2.52e-01	5.97e-01
Signaling-by-VEGF	100	1.03e-01	2.44e-01	0.15900	-1.19e-01	0.105000	3.98e-02	6.86e-02
EPHB-mediated-forward-signaling	32	1.03e-01	2.44e-01	0.28200	2.05e-01	-0.193000	4.45e-02	5.86e-02
Regulation-of-beta-cell-development	35	1.04e-01	2.44e-01	0.26700	-2.01e-01	0.175000	3.91e-02	7.25e-02
RUNX3-regulates-NOTCH-signaling	14	1.04e-01	2.44e-01	0.42000	-3.21e-01	0.270000	3.74e-02	7.98e-02
Positive-epigenetic-regulation-of-rRNA-expression	43	1.04e-01	2.45e-01	0.23900	-1.54e-01	0.183000	8.12e-02	3.74e-02
Initiation-of-Nuclear-Envelope-(NE)-Reformation	19	1.05e-01	2.47e-01	0.16300	1.41e-01	0.080700	2.87e-01	5.42e-01
Resolution-of-AP-sites-via-the-multiple-nucleotide-patch-replacement-pathway	24	1.05e-01	2.47e-01	0.20000	1.98e-01	-0.024600	9.25e-02	8.34e-01
Transport-to-the-Golgi-and-subsequent-modification	161	1.06e-01	2.47e-01	0.09650	8.98e-02	-0.035200	4.91e-02	4.40e-01
Negative-regulation-of-NMDA-receptor-mediated-neuronal-transmission	21	1.06e-01	2.47e-01	0.17900	1.78e-01	0.023700	1.59e-01	8.51e-01
Gamma-carboxylation,-transport,-and-amino-terminal-cleavage-of-proteins	11	1.06e-01	2.47e-01	0.34300	-1.01e-01	0.328000	5.62e-01	5.98e-02
TRAF6-mediated-induction-of-NFkB-and-MAP-kinases-upon-TLR7/8-or-9-activation	84	1.07e-01	2.48e-01	0.17000	1.09e-01	-0.131000	8.28e-02	3.84e-02
Mismatch-Repair	14	1.09e-01	2.52e-01	0.18300	1.32e-01	0.127000	3.93e-01	4.12e-01
G-alpha-(i)-signalling-events	248	1.09e-01	2.52e-01	0.04810	1.40e-02	0.046100	7.04e-01	2.11e-01
RND3-GTPase-cycle	41	1.09e-01	2.52e-01	0.14200	1.42e-01	-0.005690	1.15e-01	9.50e-01
Constitutive-Signaling-by-Aberrant-PI3K-in-Cancer	71	1.09e-01	2.52e-01	0.18000	-1.44e-01	0.108000	3.60e-02	1.14e-01
Beta-catenin-independent-WNT-signaling	140	1.09e-01	2.52e-01	0.07450	-9.10e-04	-0.074500	9.85e-01	1.28e-01
Molecules-associated-with-elastic-fibres	29	1.09e-01	2.52e-01	0.17300	-1.14e-02	0.172000	9.16e-01	1.08e-01
Constitutive-Signaling-by-Ligand-Responsive-EGFR-Cancer-Variants	18	1.10e-01	2.53e-01	0.16300	-9.24e-02	-0.134000	4.97e-01	3.25e-01
Signaling-by-Ligand-Responsive-EGFR-Variants-in-Cancer	18	1.10e-01	2.53e-01	0.16300	-9.24e-02	-0.134000	4.97e-01	3.25e-01
RAS-processing	18	1.11e-01	2.54e-01	0.29700	1.21e-01	-0.271000	3.74e-01	4.62e-02
FLT3-signaling-in-disease	27	1.11e-01	2.55e-01	0.14700	-3.82e-02	-0.142000	7.31e-01	2.03e-01
Regulation-of-innate-immune-responses-to-cytosolic-DNA	12	1.11e-01	2.55e-01	0.42100	-3.49e-01	0.236000	3.61e-02	1.57e-01
Signal-regulatory-protein-family-interactions	11	1.12e-01	2.55e-01	0.43700	-2.40e-01	0.364000	1.67e-01	3.63e-02
Fanconi-Anemia-Pathway	34	1.12e-01	2.55e-01	0.25500	2.07e-01	-0.149000	3.66e-02	1.32e-01
Dual-incision-in-TC-NER	64	1.12e-01	2.55e-01	0.10100	9.95e-02	0.014900	1.68e-01	8.37e-01
Post-translational-modification:-synthesis-of-GPI-anchored-proteins	76	1.14e-01	2.59e-01	0.14200	1.31e-01	-0.056300	4.90e-02	3.96e-01
RNA-Polymerase-I-Transcription-Termination	28	1.15e-01	2.60e-01	0.24000	-1.02e-01	0.218000	3.52e-01	4.61e-02
TRAF6-mediated-induction-of-TAK1-complex-within-TLR4-complex	15	1.15e-01	2.60e-01	0.36000	1.85e-01	-0.308000	2.14e-01	3.87e-02
Metabolic-disorders-of-biological-oxidation-enzymes	32	1.15e-01	2.61e-01	0.18300	3.89e-02	-0.179000	7.03e-01	7.99e-02
Blood-group-systems-biosynthesis	17	1.16e-01	2.62e-01	0.25000	-5.29e-02	0.245000	7.06e-01	8.07e-02
Lewis-blood-group-biosynthesis	15	1.18e-01	2.66e-01	0.25800	-4.65e-02	0.254000	7.55e-01	8.82e-02
MyD88-independent-TLR4-cascade	92	1.18e-01	2.66e-01	0.13000	5.28e-02	-0.118000	3.81e-01	4.95e-02
TRIF(TICAM1)-mediated-TLR4-signaling	92	1.18e-01	2.66e-01	0.13000	5.28e-02	-0.118000	3.81e-01	4.95e-02
Classical-antibody-mediated-complement-activation	18	1.20e-01	2.70e-01	0.25300	-2.44e-01	0.067200	7.26e-02	6.22e-01
Role-of-phospholipids-in-phagocytosis	36	1.20e-01	2.70e-01	0.25500	-1.68e-01	0.192000	8.15e-02	4.64e-02
trans-Golgi-Network-Vesicle-Budding	71	1.21e-01	2.71e-01	0.15000	6.45e-02	-0.136000	3.47e-01	4.82e-02
Rap1-signalling	14	1.21e-01	2.71e-01	0.26400	-2.60e-01	0.045400	9.22e-02	7.68e-01
S33-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
S37-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
S45-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
Signaling-by-CTNNB1-phospho-site-mutants	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
Signaling-by-GSK3beta-mutants	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
T41-mutants-of-beta-catenin-aren’t-phosphorylated	15	1.22e-01	2.71e-01	0.23100	2.31e-01	-0.012000	1.21e-01	9.36e-01
Programmed-Cell-Death	185	1.24e-01	2.74e-01	0.11000	6.83e-02	-0.086100	1.09e-01	4.31e-02
Reduction-of-cytosolic-Ca++-levels	12	1.25e-01	2.76e-01	0.25400	2.54e-01	-0.008870	1.28e-01	9.58e-01
RHO-GTPases-activate-PKNs	32	1.25e-01	2.77e-01	0.25200	2.08e-01	-0.143000	4.16e-02	1.62e-01
E3-ubiquitin-ligases-ubiquitinate-target-proteins	40	1.26e-01	2.77e-01	0.18400	-1.72e-01	0.065500	5.99e-02	4.73e-01
DAP12-signaling	28	1.26e-01	2.77e-01	0.28400	-1.83e-01	0.217000	9.32e-02	4.66e-02
RHO-GTPases-Activate-NADPH-Oxidases	23	1.26e-01	2.77e-01	0.31600	-2.10e-01	0.236000	8.06e-02	5.02e-02
Activation-of-ATR-in-response-to-replication-stress	37	1.28e-01	2.80e-01	0.12100	1.17e-01	0.031900	2.19e-01	7.37e-01
PKA-activation	17	1.28e-01	2.82e-01	0.26000	-7.19e-02	0.249000	6.08e-01	7.50e-02
Regulation-of-gene-expression-in-late-stage-(branching-morphogenesis)-pancreatic-bud-precursor-cells	14	1.29e-01	2.82e-01	0.40500	-2.92e-01	0.281000	5.84e-02	6.87e-02
rRNA-processing-in-the-mitochondrion	19	1.29e-01	2.83e-01	0.34700	2.53e-01	-0.237000	5.58e-02	7.36e-02
Viral-Messenger-RNA-Synthesis	42	1.31e-01	2.85e-01	0.17900	1.67e-01	-0.064400	6.17e-02	4.70e-01
VxPx-cargo-targeting-to-cilium	20	1.31e-01	2.85e-01	0.28300	-1.27e-01	0.253000	3.27e-01	5.04e-02
Condensation-of-Prophase-Chromosomes	14	1.34e-01	2.91e-01	0.37600	3.10e-01	-0.213000	4.48e-02	1.68e-01
Abacavir-transport-and-metabolism	10	1.35e-01	2.94e-01	0.39900	-1.81e-01	0.355000	3.22e-01	5.17e-02
Signaling-by-NTRKs	131	1.35e-01	2.94e-01	0.08890	-2.08e-02	0.086400	6.81e-01	8.75e-02
mRNA-Splicing—Major-Pathway	175	1.35e-01	2.94e-01	0.04950	-3.90e-02	-0.030400	3.73e-01	4.87e-01
Chromosome-Maintenance	88	1.36e-01	2.94e-01	0.11600	1.11e-01	-0.036300	7.27e-02	5.56e-01
Signaling-by-ERBB2-TMD/JMD-mutants	21	1.36e-01	2.94e-01	0.23300	6.73e-02	-0.223000	5.94e-01	7.70e-02
Mucopolysaccharidoses	11	1.36e-01	2.94e-01	0.37900	-3.38e-01	0.172000	5.24e-02	3.24e-01
Global-Genome-Nucleotide-Excision-Repair-(GG-NER)	82	1.37e-01	2.94e-01	0.07170	4.74e-02	0.053700	4.57e-01	4.00e-01
Regulation-of-RUNX1-Expression-and-Activity	17	1.37e-01	2.94e-01	0.33600	-1.86e-01	0.279000	1.84e-01	4.62e-02
PERK-regulates-gene-expression	29	1.37e-01	2.95e-01	0.18700	4.27e-02	-0.182000	6.91e-01	8.99e-02
Beta-catenin-phosphorylation-cascade	17	1.38e-01	2.95e-01	0.21300	2.12e-01	-0.013600	1.29e-01	9.23e-01
Homology-Directed-Repair	100	1.38e-01	2.95e-01	0.07360	7.17e-02	0.016700	2.15e-01	7.73e-01
DNA-Damage-Bypass	46	1.38e-01	2.95e-01	0.21000	1.69e-01	-0.124000	4.70e-02	1.47e-01
Scavenging-by-Class-A-Receptors	18	1.38e-01	2.95e-01	0.19300	6.55e-03	0.193000	9.62e-01	1.56e-01
RA-biosynthesis-pathway	19	1.38e-01	2.95e-01	0.32600	-2.63e-01	0.192000	4.72e-02	1.47e-01
Pyrimidine-catabolism	12	1.38e-01	2.95e-01	0.38500	1.99e-01	-0.330000	2.32e-01	4.80e-02
Receptor-Mediated-Mitophagy	11	1.39e-01	2.95e-01	0.33900	1.18e-01	-0.318000	4.99e-01	6.79e-02
RND1-GTPase-cycle	41	1.42e-01	3.02e-01	0.17700	-6.45e-02	0.165000	4.75e-01	6.71e-02
MET-activates-RAP1-and-RAC1	11	1.43e-01	3.03e-01	0.27400	-2.72e-01	0.033700	1.18e-01	8.46e-01
Negative-regulation-of-FLT3	14	1.43e-01	3.04e-01	0.26800	-2.60e-01	0.063400	9.17e-02	6.81e-01
ADORA2B-mediated-anti-inflammatory-cytokines-production	107	1.44e-01	3.05e-01	0.09460	-1.98e-02	0.092500	7.23e-01	9.83e-02
SUMOylation-of-transcription-cofactors	41	1.45e-01	3.06e-01	0.20100	-1.75e-01	0.099200	5.24e-02	2.72e-01
Signalling-to-RAS	20	1.45e-01	3.06e-01	0.22000	-4.79e-02	0.214000	7.11e-01	9.69e-02
Ketone-body-metabolism	10	1.45e-01	3.06e-01	0.33800	-3.21e-01	0.104000	7.85e-02	5.70e-01
Ca-dependent-events	35	1.46e-01	3.06e-01	0.14100	-2.04e-03	0.141000	9.83e-01	1.48e-01
Lysine-catabolism	12	1.46e-01	3.06e-01	0.40500	-3.26e-01	0.240000	5.04e-02	1.50e-01
Neutrophil-degranulation	420	1.46e-01	3.06e-01	0.06720	3.77e-02	-0.055700	1.85e-01	4.98e-02
Translesion-synthesis-by-POLI	16	1.47e-01	3.07e-01	0.32600	2.81e-01	-0.166000	5.19e-02	2.50e-01
Energy-dependent-regulation-of-mTOR-by-LKB1-AMPK	29	1.47e-01	3.08e-01	0.12900	1.22e-01	0.041200	2.56e-01	7.01e-01
Signaling-by-FGFR1-in-disease	34	1.49e-01	3.10e-01	0.14800	1.02e-02	-0.148000	9.18e-01	1.36e-01
Transcriptional-regulation-by-RUNX1	171	1.49e-01	3.11e-01	0.06070	-6.06e-02	-0.003430	1.71e-01	9.38e-01
Telomere-Maintenance	65	1.49e-01	3.11e-01	0.08360	7.71e-02	0.032300	2.82e-01	6.52e-01
Toll-Like-Receptor-3-(TLR3)-Cascade	88	1.50e-01	3.12e-01	0.13300	6.28e-02	-0.118000	3.08e-01	5.65e-02
Nuclear-Envelope-(NE)-Reassembly	68	1.51e-01	3.13e-01	0.08660	8.41e-02	0.020700	2.30e-01	7.68e-01
Ion-homeostasis	49	1.52e-01	3.14e-01	0.10200	9.97e-02	0.023200	2.27e-01	7.79e-01
Acyl-chain-remodelling-of-PS	18	1.52e-01	3.14e-01	0.34300	2.42e-01	-0.243000	7.51e-02	7.45e-02
Sema4D-induced-cell-migration-and-growth-cone-collapse	19	1.52e-01	3.15e-01	0.21400	2.11e-01	-0.037400	1.11e-01	7.78e-01
PINK1-PRKN-Mediated-Mitophagy	21	1.53e-01	3.15e-01	0.28500	1.49e-01	-0.243000	2.37e-01	5.36e-02
Triglyceride-metabolism	31	1.53e-01	3.15e-01	0.26000	1.91e-01	-0.176000	6.52e-02	8.95e-02
Signaling-by-Erythropoietin	25	1.54e-01	3.17e-01	0.18200	-1.80e-01	0.026800	1.19e-01	8.17e-01
Diseases-associated-with-glycosylation-precursor-biosynthesis	17	1.54e-01	3.17e-01	0.25500	2.43e-01	-0.078200	8.33e-02	5.76e-01
Negative-regulation-of-MAPK-pathway	42	1.56e-01	3.20e-01	0.20100	1.06e-01	-0.171000	2.34e-01	5.48e-02
FLT3-Signaling	37	1.56e-01	3.20e-01	0.17300	-1.65e-01	0.054600	8.30e-02	5.66e-01
Regulation-of-TP53-Expression-and-Degradation	34	1.57e-01	3.21e-01	0.24700	1.73e-01	-0.177000	8.01e-02	7.47e-02
HDR-through-MMEJ-(alt-NHEJ)	10	1.57e-01	3.21e-01	0.19700	1.36e-01	0.143000	4.56e-01	4.34e-01
Toll-Like-Receptor-9-(TLR9)-Cascade	89	1.57e-01	3.21e-01	0.15000	9.54e-02	-0.116000	1.19e-01	5.90e-02
RAF-activation	34	1.58e-01	3.22e-01	0.24100	1.52e-01	-0.188000	1.26e-01	5.82e-02
Nucleobase-biosynthesis	15	1.61e-01	3.27e-01	0.21000	2.10e-01	-0.002590	1.60e-01	9.86e-01
Carboxyterminal-post-translational-modifications-of-tubulin	34	1.62e-01	3.29e-01	0.12000	1.16e-01	0.028900	2.40e-01	7.71e-01
Dissolution-of-Fibrin-Clot	12	1.63e-01	3.30e-01	0.18300	-1.57e-01	-0.094400	3.48e-01	5.71e-01
Sensory-Perception	189	1.64e-01	3.32e-01	0.09820	8.01e-02	-0.056800	5.74e-02	1.77e-01
BMAL1:CLOCK,NPAS2-activates-circadian-gene-expression	25	1.64e-01	3.32e-01	0.15300	-1.10e-02	-0.152000	9.24e-01	1.87e-01
AURKA-Activation-by-TPX2	70	1.64e-01	3.32e-01	0.14600	1.29e-01	-0.069000	6.26e-02	3.18e-01
SUMO-E3-ligases-SUMOylate-target-proteins	160	1.65e-01	3.33e-01	0.10800	-8.65e-02	0.065000	5.87e-02	1.56e-01
Josephin-domain-DUBs	10	1.65e-01	3.33e-01	0.39700	-3.43e-01	0.200000	6.01e-02	2.73e-01
Regulated-Necrosis	47	1.65e-01	3.33e-01	0.19500	1.12e-01	-0.160000	1.83e-01	5.79e-02
Interleukin-6-signaling	11	1.67e-01	3.35e-01	0.42700	-2.91e-01	0.312000	9.49e-02	7.30e-02
Adenylate-cyclase-activating-pathway	10	1.67e-01	3.35e-01	0.38500	-1.83e-01	0.339000	3.17e-01	6.35e-02
Heme-biosynthesis	14	1.67e-01	3.35e-01	0.37800	-2.75e-01	0.259000	7.48e-02	9.28e-02
GRB2:SOS-provides-linkage-to-MAPK-signaling-for-Integrins	15	1.68e-01	3.35e-01	0.31200	2.76e-01	-0.146000	6.45e-02	3.28e-01
Repression-of-WNT-target-genes	13	1.68e-01	3.35e-01	0.20000	1.98e-01	0.031600	2.17e-01	8.43e-01
Disorders-of-Developmental-Biology	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Disorders-of-Nervous-System-Development	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Loss-of-function-of-MECP2-in-Rett-syndrome	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Pervasive-developmental-disorders	11	1.69e-01	3.37e-01	0.36600	-3.22e-01	0.174000	6.45e-02	3.18e-01
Sema4D-in-semaphorin-signaling	23	1.70e-01	3.38e-01	0.15800	1.57e-01	0.011400	1.92e-01	9.25e-01
Digestion-and-absorption	15	1.71e-01	3.39e-01	0.35600	2.76e-01	-0.226000	6.45e-02	1.30e-01
Signaling-by-NOTCH1	72	1.72e-01	3.40e-01	0.16500	-1.12e-01	0.122000	1.00e-01	7.41e-02
Signaling-by-FGFR	78	1.72e-01	3.41e-01	0.06920	-5.30e-02	-0.044400	4.18e-01	4.98e-01
Neurotransmitter-release-cycle	46	1.75e-01	3.45e-01	0.17900	1.57e-01	-0.086900	6.59e-02	3.07e-01
Zinc-influx-into-cells-by-the-SLC39-gene-family	10	1.75e-01	3.45e-01	0.25700	1.23e-02	-0.257000	9.46e-01	1.60e-01
Formation-of-HIV-1-elongation-complex-containing-HIV-1-Tat	39	1.75e-01	3.45e-01	0.09860	8.24e-02	0.054200	3.73e-01	5.58e-01
HIV-Transcription-Elongation	39	1.75e-01	3.45e-01	0.09860	8.24e-02	0.054200	3.73e-01	5.58e-01
Tat-mediated-elongation-of-the-HIV-1-transcript	39	1.75e-01	3.45e-01	0.09860	8.24e-02	0.054200	3.73e-01	5.58e-01
Reproduction	75	1.78e-01	3.49e-01	0.15600	1.23e-01	-0.095100	6.50e-02	1.54e-01
RHO-GTPases-activate-CIT	18	1.79e-01	3.50e-01	0.15100	1.40e-01	0.057500	3.04e-01	6.73e-01
PKA-activation-in-glucagon-signalling	16	1.79e-01	3.51e-01	0.29600	-1.39e-01	0.262000	3.36e-01	6.97e-02
Polo-like-kinase-mediated-events	16	1.80e-01	3.51e-01	0.34700	2.50e-01	-0.241000	8.36e-02	9.57e-02
Formation-of-the-cornified-envelope	35	1.80e-01	3.51e-01	0.23300	1.56e-01	-0.173000	1.10e-01	7.57e-02
SUMOylation-of-DNA-methylation-proteins	16	1.80e-01	3.52e-01	0.31800	-2.67e-01	0.173000	6.46e-02	2.32e-01
RHOV-GTPase-cycle	37	1.82e-01	3.54e-01	0.16400	4.88e-02	-0.156000	6.07e-01	9.99e-02
Regulation-of-TP53-Activity-through-Phosphorylation	88	1.84e-01	3.59e-01	0.11500	1.06e-01	-0.043700	8.51e-02	4.78e-01
RAF-independent-MAPK1/3-activation	23	1.85e-01	3.59e-01	0.15400	-1.54e-01	-0.010500	2.01e-01	9.30e-01
G-protein-mediated-events	51	1.86e-01	3.60e-01	0.09020	3.08e-02	0.084800	7.03e-01	2.95e-01
PI3K/AKT-Signaling-in-Cancer	98	1.87e-01	3.60e-01	0.13300	-1.07e-01	0.079100	6.81e-02	1.76e-01
Transcriptional-regulation-of-testis-differentiation	12	1.88e-01	3.60e-01	0.31000	2.86e-01	-0.120000	8.57e-02	4.72e-01
Disorders-of-transmembrane-transporters	169	1.88e-01	3.60e-01	0.09590	5.10e-02	-0.081200	2.52e-01	6.82e-02
Activated-NOTCH1-Transmits-Signal-to-the-Nucleus	30	1.88e-01	3.60e-01	0.22600	-1.92e-01	0.120000	6.85e-02	2.56e-01
Constitutive-Signaling-by-NOTCH1-HD+PEST-Domain-Mutants	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Constitutive-Signaling-by-NOTCH1-PEST-Domain-Mutants	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Signaling-by-NOTCH1-HD+PEST-Domain-Mutants-in-Cancer	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Signaling-by-NOTCH1-PEST-Domain-Mutants-in-Cancer	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
Signaling-by-NOTCH1-in-Cancer	56	1.88e-01	3.60e-01	0.17900	-1.39e-01	0.112000	7.12e-02	1.48e-01
RNA-Polymerase-III-Abortive-And-Retractive-Initiation	41	1.89e-01	3.60e-01	0.14700	3.67e-02	-0.142000	6.84e-01	1.15e-01
RNA-Polymerase-III-Transcription	41	1.89e-01	3.60e-01	0.14700	3.67e-02	-0.142000	6.84e-01	1.15e-01
HIV-Life-Cycle	137	1.89e-01	3.60e-01	0.09320	8.54e-02	-0.037200	8.40e-02	4.52e-01
Constitutive-Signaling-by-NOTCH1-HD-Domain-Mutants	14	1.89e-01	3.60e-01	0.25500	-2.46e-01	0.067300	1.12e-01	6.63e-01
Signaling-by-NOTCH1-HD-Domain-Mutants-in-Cancer	14	1.89e-01	3.60e-01	0.25500	-2.46e-01	0.067300	1.12e-01	6.63e-01
Regulation-of-Insulin-like-Growth-Factor-(IGF)-transport-and-uptake-by-Insulin-like-Growth-Factor-Binding-Proteins-(IGFBPs)	111	1.89e-01	3.60e-01	0.13000	9.17e-02	-0.092100	9.48e-02	9.34e-02
Potential-therapeutics-for-SARS	81	1.93e-01	3.67e-01	0.15100	-1.10e-01	0.103000	8.57e-02	1.10e-01
RNA-Polymerase-II-Transcription	1027	1.93e-01	3.67e-01	0.02220	-2.20e-02	-0.003200	2.31e-01	8.62e-01
Keratan-sulfate-biosynthesis	24	1.94e-01	3.67e-01	0.19100	-4.87e-02	0.185000	6.80e-01	1.17e-01
Activation-of-IRF3/IRF7-mediated-by-TBK1/IKK-epsilon	16	1.95e-01	3.69e-01	0.15000	-1.29e-01	-0.077200	3.72e-01	5.93e-01
Late-endosomal-microautophagy	29	1.95e-01	3.69e-01	0.24800	1.59e-01	-0.190000	1.37e-01	7.72e-02
SUMOylation-of-chromatin-organization-proteins	54	1.97e-01	3.72e-01	0.18200	-1.18e-01	0.138000	1.33e-01	7.94e-02
RHOQ-GTPase-cycle	59	1.99e-01	3.74e-01	0.15900	-8.37e-02	0.135000	2.66e-01	7.32e-02
p75NTR-recruits-signalling-complexes	12	1.99e-01	3.75e-01	0.20800	-1.47e-02	-0.208000	9.30e-01	2.12e-01
NoRC-negatively-regulates-rRNA-expression	44	1.99e-01	3.75e-01	0.19500	-1.17e-01	0.156000	1.80e-01	7.36e-02
Metabolism-of-folate-and-pterines	15	2.00e-01	3.75e-01	0.24200	2.33e-01	-0.063600	1.18e-01	6.70e-01
RHOF-GTPase-cycle	41	2.00e-01	3.75e-01	0.21000	-1.49e-01	0.148000	9.93e-02	1.00e-01
COPI-dependent-Golgi-to-ER-retrograde-traffic	78	2.00e-01	3.75e-01	0.08670	8.66e-02	-0.001540	1.86e-01	9.81e-01
Disease	1478	2.01e-01	3.76e-01	0.03290	2.76e-02	-0.017900	7.36e-02	2.45e-01
Fatty-acyl-CoA-biosynthesis	32	2.01e-01	3.76e-01	0.17400	5.60e-02	-0.165000	5.83e-01	1.06e-01
Cell-Cell-communication	110	2.02e-01	3.76e-01	0.08630	8.40e-02	-0.019700	1.28e-01	7.21e-01
Pre-NOTCH-Transcription-and-Translation	34	2.02e-01	3.76e-01	0.18700	-7.93e-02	0.170000	4.24e-01	8.64e-02
Creation-of-C4-and-C2-activators	23	2.02e-01	3.76e-01	0.18900	-1.84e-01	0.044200	1.27e-01	7.13e-01
Triglyceride-biosynthesis	11	2.03e-01	3.77e-01	0.34300	1.60e-01	-0.304000	3.58e-01	8.10e-02
Diseases-associated-with-the-TLR-signaling-cascade	29	2.04e-01	3.77e-01	0.22500	1.20e-01	-0.191000	2.64e-01	7.54e-02
Diseases-of-Immune-System	29	2.04e-01	3.77e-01	0.22500	1.20e-01	-0.191000	2.64e-01	7.54e-02
Synthesis-of-Leukotrienes-(LT)-and-Eoxins-(EX)	15	2.04e-01	3.77e-01	0.15200	8.50e-02	0.125000	5.68e-01	4.00e-01
ERBB2-Activates-PTK6-Signaling	13	2.04e-01	3.77e-01	0.20800	-3.85e-04	-0.208000	9.98e-01	1.94e-01
Post-translational-protein-phosphorylation	99	2.04e-01	3.77e-01	0.13300	1.00e-01	-0.087800	8.48e-02	1.31e-01
Cell-extracellular-matrix-interactions	16	2.04e-01	3.77e-01	0.15000	-1.32e-01	-0.070300	3.59e-01	6.27e-01
IL-6-type-cytokine-receptor-ligand-interactions	16	2.06e-01	3.79e-01	0.30400	-2.56e-01	0.164000	7.59e-02	2.55e-01
Resolution-of-D-Loop-Structures	33	2.06e-01	3.79e-01	0.10500	9.38e-02	0.046800	3.51e-01	6.42e-01
Signaling-by-Insulin-receptor	71	2.06e-01	3.79e-01	0.15100	1.22e-01	-0.089800	7.63e-02	1.91e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-2-Promoter	27	2.07e-01	3.80e-01	0.25200	1.93e-01	-0.163000	8.29e-02	1.43e-01
Signaling-by-Interleukins	409	2.08e-01	3.82e-01	0.03140	-2.99e-02	-0.009630	2.99e-01	7.38e-01
Gene-expression-(Transcription)	1158	2.09e-01	3.82e-01	0.02330	-2.32e-02	0.001300	1.80e-01	9.40e-01
Sensory-processing-of-sound-by-outer-hair-cells-of-the-cochlea	48	2.09e-01	3.82e-01	0.13500	1.30e-01	-0.037600	1.20e-01	6.52e-01
Gene-Silencing-by-RNA	74	2.10e-01	3.83e-01	0.07420	7.13e-02	0.020500	2.89e-01	7.61e-01
Constitutive-Signaling-by-Overexpressed-ERBB2	10	2.10e-01	3.83e-01	0.18300	-1.07e-01	-0.149000	5.60e-01	4.15e-01
Pyrimidine-salvage	10	2.10e-01	3.83e-01	0.41300	3.14e-01	-0.268000	8.55e-02	1.42e-01
Signaling-by-NOTCH2	31	2.11e-01	3.83e-01	0.23100	-1.81e-01	0.144000	8.08e-02	1.67e-01
tRNA-modification-in-the-nucleus-and-cytosol	41	2.12e-01	3.86e-01	0.20400	-1.32e-01	0.155000	1.42e-01	8.68e-02
Unwinding-of-DNA	12	2.14e-01	3.88e-01	0.17000	1.49e-01	0.081800	3.71e-01	6.24e-01
SARS-CoV-Infections	147	2.14e-01	3.88e-01	0.10900	-7.56e-02	0.078200	1.13e-01	1.01e-01
Leading-Strand-Synthesis	14	2.15e-01	3.88e-01	0.16100	1.47e-01	0.065400	3.42e-01	6.72e-01
Polymerase-switching	14	2.15e-01	3.88e-01	0.16100	1.47e-01	0.065400	3.42e-01	6.72e-01
Tight-junction-interactions	28	2.15e-01	3.88e-01	0.24600	1.61e-01	-0.186000	1.40e-01	8.88e-02
Constitutive-Signaling-by-EGFRvIII	15	2.15e-01	3.88e-01	0.16800	-1.64e-01	-0.036400	2.72e-01	8.07e-01
Signaling-by-EGFRvIII-in-Cancer	15	2.15e-01	3.88e-01	0.16800	-1.64e-01	-0.036400	2.72e-01	8.07e-01
Pre-NOTCH-Expression-and-Processing	50	2.15e-01	3.88e-01	0.13000	-3.53e-02	0.125000	6.66e-01	1.25e-01
Interleukin-6-family-signaling	23	2.16e-01	3.88e-01	0.27400	-1.93e-01	0.194000	1.10e-01	1.07e-01
Cell-junction-organization	78	2.17e-01	3.89e-01	0.14100	1.14e-01	-0.083000	8.08e-02	2.05e-01
Signaling-by-TGF-beta-Receptor-Complex	71	2.18e-01	3.92e-01	0.06960	-3.30e-02	-0.061300	6.30e-01	3.72e-01
Ovarian-tumor-domain-proteases	35	2.20e-01	3.94e-01	0.20300	1.12e-01	-0.170000	2.51e-01	8.20e-02
RNA-Polymerase-III-Chain-Elongation	18	2.21e-01	3.95e-01	0.30600	2.26e-01	-0.205000	9.65e-02	1.31e-01
Activation-of-HOX-genes-during-differentiation	61	2.21e-01	3.95e-01	0.16300	-1.02e-01	0.127000	1.66e-01	8.69e-02
Activation-of-anterior-HOX-genes-in-hindbrain-development-during-early-embryogenesis	61	2.21e-01	3.95e-01	0.16300	-1.02e-01	0.127000	1.66e-01	8.69e-02
RNA-polymerase-II-transcribes-snRNA-genes	77	2.21e-01	3.95e-01	0.07030	-2.20e-02	-0.066800	7.39e-01	3.10e-01
Formation-of-HIV-elongation-complex-in-the-absence-of-HIV-Tat	41	2.21e-01	3.95e-01	0.09910	9.60e-02	0.024500	2.87e-01	7.86e-01
Extension-of-Telomeres	50	2.22e-01	3.95e-01	0.08230	3.98e-02	0.072000	6.26e-01	3.78e-01
Synthesis-of-PIPs-at-the-late-endosome-membrane	11	2.26e-01	4.02e-01	0.22800	-1.25e-02	0.227000	9.43e-01	1.92e-01
NRAGE-signals-death-through-JNK	58	2.29e-01	4.06e-01	0.09170	4.79e-03	0.091600	9.50e-01	2.27e-01
Interactions-of-Rev-with-host-cellular-proteins	34	2.30e-01	4.06e-01	0.10100	4.13e-02	0.091900	6.77e-01	3.54e-01
Regulation-of-glycolysis-by-fructose-2,6-bisphosphate-metabolism	11	2.30e-01	4.06e-01	0.24300	2.40e-01	-0.035100	1.68e-01	8.40e-01
Tetrahydrobiopterin-(BH4)-synthesis,-recycling,-salvage-and-regulation	10	2.30e-01	4.06e-01	0.18900	-1.75e-01	-0.069100	3.37e-01	7.05e-01
MET-promotes-cell-motility	29	2.30e-01	4.06e-01	0.18600	-7.01e-02	0.172000	5.13e-01	1.09e-01
Signaling-by-WNT-in-cancer	33	2.31e-01	4.08e-01	0.14400	1.41e-01	-0.025200	1.60e-01	8.02e-01
Defects-in-vitamin-and-cofactor-metabolism	20	2.32e-01	4.08e-01	0.25400	-2.19e-01	0.128000	9.01e-02	3.21e-01
Extra-nuclear-estrogen-signaling	71	2.32e-01	4.08e-01	0.09570	9.47e-02	-0.014300	1.68e-01	8.35e-01
Metalloprotease-DUBs	19	2.32e-01	4.08e-01	0.28200	1.69e-01	-0.226000	2.01e-01	8.87e-02
PI3K-events-in-ERBB4-signaling	10	2.33e-01	4.10e-01	0.32800	1.38e-01	-0.298000	4.51e-01	1.03e-01
Smooth-Muscle-Contraction	36	2.34e-01	4.11e-01	0.17500	-7.62e-02	0.158000	4.29e-01	1.01e-01
RNA-Polymerase-I-Promoter-Escape	28	2.35e-01	4.11e-01	0.17100	-4.80e-02	0.164000	6.60e-01	1.34e-01
ER-to-Golgi-Anterograde-Transport	133	2.35e-01	4.11e-01	0.07750	7.46e-02	-0.020800	1.37e-01	6.78e-01
Interleukin-10-signaling	39	2.37e-01	4.14e-01	0.20300	-1.41e-01	0.147000	1.27e-01	1.13e-01
Presynaptic-depolarization-and-calcium-channel-opening	12	2.37e-01	4.14e-01	0.22500	2.24e-01	-0.026900	1.80e-01	8.72e-01
Erythrocytes-take-up-carbon-dioxide-and-release-oxygen	12	2.38e-01	4.14e-01	0.18900	2.57e-02	0.187000	8.78e-01	2.61e-01
O2/CO2-exchange-in-erythrocytes	12	2.38e-01	4.14e-01	0.18900	2.57e-02	0.187000	8.78e-01	2.61e-01
Neurotoxicity-of-clostridium-toxins	10	2.38e-01	4.14e-01	0.37600	2.15e-01	-0.309000	2.40e-01	9.03e-02
GRB2-events-in-ERBB2-signaling	16	2.39e-01	4.15e-01	0.26400	1.18e-01	-0.237000	4.14e-01	1.01e-01
Collagen-degradation	36	2.40e-01	4.16e-01	0.17400	-7.51e-02	0.157000	4.36e-01	1.04e-01
Signaling-by-FGFR3-in-disease	20	2.40e-01	4.16e-01	0.21000	6.89e-02	-0.198000	5.94e-01	1.25e-01
Signaling-by-FGFR3-point-mutants-in-cancer	20	2.40e-01	4.16e-01	0.21000	6.89e-02	-0.198000	5.94e-01	1.25e-01
Interactions-of-Vpr-with-host-cellular-proteins	34	2.41e-01	4.17e-01	0.17400	1.59e-01	-0.070800	1.09e-01	4.75e-01
PI-3K-cascade:FGFR4	17	2.42e-01	4.19e-01	0.13300	-8.49e-02	-0.102000	5.44e-01	4.65e-01
Negative-epigenetic-regulation-of-rRNA-expression	47	2.43e-01	4.19e-01	0.17200	-9.81e-02	0.142000	2.44e-01	9.24e-02
GRB2-events-in-EGFR-signaling	12	2.43e-01	4.19e-01	0.34500	2.02e-01	-0.280000	2.25e-01	9.31e-02
N-glycan-antennae-elongation-in-the-medial/trans-Golgi	23	2.44e-01	4.21e-01	0.18100	1.75e-01	-0.046500	1.46e-01	7.00e-01
Chaperone-Mediated-Autophagy	19	2.45e-01	4.21e-01	0.13700	-4.10e-02	-0.131000	7.57e-01	3.22e-01
Biotin-transport-and-metabolism	11	2.45e-01	4.21e-01	0.37800	-2.62e-01	0.273000	1.32e-01	1.17e-01
RNA-Polymerase-III-Transcription-Initiation	36	2.46e-01	4.21e-01	0.20100	1.21e-01	-0.161000	2.08e-01	9.54e-02
HDACs-deacetylate-histones	31	2.48e-01	4.24e-01	0.19000	-1.69e-01	0.086700	1.04e-01	4.03e-01
E2F-mediated-regulation-of-DNA-replication	22	2.48e-01	4.24e-01	0.26500	1.97e-01	-0.178000	1.10e-01	1.48e-01
KSRP-(KHSRP)-binds-and-destabilizes-mRNA	15	2.48e-01	4.25e-01	0.31600	-2.45e-01	0.199000	1.00e-01	1.82e-01
Inactivation-of-APC/C-via-direct-inhibition-of-the-APC/C-complex	21	2.50e-01	4.26e-01	0.25400	2.10e-01	-0.143000	9.58e-02	2.55e-01
Inhibition-of-the-proteolytic-activity-of-APC/C-required-for-the-onset-of-anaphase-by-mitotic-spindle-checkpoint-components	21	2.50e-01	4.26e-01	0.25400	2.10e-01	-0.143000	9.58e-02	2.55e-01
p75NTR-signals-via-NF-kB	15	2.51e-01	4.27e-01	0.23900	7.94e-02	-0.226000	5.94e-01	1.30e-01
Potassium-Channels	92	2.51e-01	4.27e-01	0.05830	5.13e-02	0.027600	3.95e-01	6.47e-01
MECP2-regulates-neuronal-receptors-and-channels	17	2.51e-01	4.27e-01	0.15600	-1.54e-01	-0.021900	2.72e-01	8.76e-01
Triglyceride-catabolism	20	2.52e-01	4.27e-01	0.23400	2.08e-01	-0.106000	1.07e-01	4.12e-01
Antimicrobial-peptides	35	2.58e-01	4.36e-01	0.11700	1.17e-01	0.000302	2.31e-01	9.98e-01
RNA-Polymerase-III-Transcription-Initiation-From-Type-1-Promoter	28	2.58e-01	4.36e-01	0.21900	1.80e-01	-0.126000	9.99e-02	2.48e-01
Interferon-gamma-signaling	70	2.58e-01	4.36e-01	0.11800	-4.76e-02	0.108000	4.91e-01	1.19e-01
Nucleotide-Excision-Repair	108	2.59e-01	4.36e-01	0.05470	5.04e-02	0.021300	3.66e-01	7.03e-01
Centrosome-maturation	77	2.59e-01	4.36e-01	0.11900	1.06e-01	-0.054700	1.09e-01	4.06e-01
Recruitment-of-mitotic-centrosome-proteins-and-complexes	77	2.59e-01	4.36e-01	0.11900	1.06e-01	-0.054700	1.09e-01	4.06e-01
Platelet-activation,-signaling-and-aggregation	244	2.59e-01	4.37e-01	0.07860	-5.25e-02	0.058500	1.57e-01	1.15e-01
Polymerase-switching-on-the-C-strand-of-the-telomere	26	2.60e-01	4.38e-01	0.12100	2.34e-02	0.118000	8.37e-01	2.96e-01
Glucuronidation	13	2.61e-01	4.39e-01	0.33800	2.25e-01	-0.252000	1.60e-01	1.15e-01
FOXO-mediated-transcription-of-cell-cycle-genes	15	2.62e-01	4.41e-01	0.31400	2.36e-01	-0.207000	1.14e-01	1.65e-01
p130Cas-linkage-to-MAPK-signaling-for-integrins	15	2.64e-01	4.43e-01	0.31200	2.36e-01	-0.203000	1.13e-01	1.72e-01
Downstream-signaling-of-activated-FGFR2	25	2.65e-01	4.43e-01	0.16200	3.37e-02	-0.158000	7.70e-01	1.71e-01
Signaling-by-ALK	26	2.66e-01	4.44e-01	0.23300	-1.82e-01	0.146000	1.08e-01	1.97e-01
Sialic-acid-metabolism	30	2.66e-01	4.44e-01	0.12400	1.30e-03	0.124000	9.90e-01	2.39e-01
Phospholipase-C-mediated-cascade;-FGFR2	13	2.67e-01	4.45e-01	0.28200	1.26e-01	-0.252000	4.33e-01	1.15e-01
Downstream-signaling-of-activated-FGFR4	24	2.67e-01	4.45e-01	0.11700	-3.87e-02	-0.110000	7.43e-01	3.49e-01
Transcriptional-regulation-by-small-RNAs	46	2.68e-01	4.46e-01	0.11400	1.13e-01	-0.018500	1.86e-01	8.28e-01
Regulation-of-PLK1-Activity-at-G2/M-Transition	84	2.71e-01	4.51e-01	0.13200	9.22e-02	-0.094700	1.44e-01	1.33e-01
Class-B/2-(Secretin-family-receptors)	79	2.72e-01	4.51e-01	0.06080	5.29e-02	0.030000	4.16e-01	6.45e-01
Activation-of-SMO	17	2.73e-01	4.52e-01	0.28600	-2.23e-01	0.179000	1.11e-01	2.02e-01
Nicotinamide-salvaging	18	2.73e-01	4.53e-01	0.27700	1.72e-01	-0.217000	2.06e-01	1.11e-01
Nuclear-Pore-Complex-(NPC)-Disassembly	34	2.74e-01	4.53e-01	0.12500	1.25e-01	-0.012900	2.08e-01	8.97e-01
Cell-cell-junction-organization	53	2.74e-01	4.53e-01	0.09720	9.70e-02	-0.005760	2.22e-01	9.42e-01
Trafficking-and-processing-of-endosomal-TLR	12	2.74e-01	4.53e-01	0.26500	9.51e-02	-0.248000	5.68e-01	1.37e-01
VEGFA-VEGFR2-Pathway	92	2.75e-01	4.53e-01	0.12500	-9.28e-02	0.084000	1.24e-01	1.63e-01
Hyaluronan-metabolism	16	2.76e-01	4.55e-01	0.13100	7.68e-02	0.107000	5.95e-01	4.60e-01
FCGR3A-mediated-phagocytosis	69	2.77e-01	4.55e-01	0.09160	-9.05e-02	0.014400	1.93e-01	8.36e-01
Leishmania-phagocytosis	69	2.77e-01	4.55e-01	0.09160	-9.05e-02	0.014400	1.93e-01	8.36e-01
Parasite-infection	69	2.77e-01	4.55e-01	0.09160	-9.05e-02	0.014400	1.93e-01	8.36e-01
Arachidonic-acid-metabolism	46	2.78e-01	4.55e-01	0.09130	9.04e-02	0.012600	2.89e-01	8.82e-01
Chk1/Chk2(Cds1)-mediated-inactivation-of-Cyclin-B:Cdk1-complex	12	2.80e-01	4.58e-01	0.34400	2.34e-01	-0.253000	1.61e-01	1.29e-01
TP53-Regulates-Transcription-of-Caspase-Activators-and-Caspases	11	2.80e-01	4.59e-01	0.35900	-2.63e-01	0.245000	1.31e-01	1.59e-01
VEGFR2-mediated-cell-proliferation	19	2.81e-01	4.59e-01	0.23200	2.06e-01	-0.107000	1.20e-01	4.20e-01
SLBP-Dependent-Processing-of-Replication-Dependent-Histone-Pre-mRNAs	10	2.81e-01	4.59e-01	0.33600	-2.89e-01	0.171000	1.14e-01	3.48e-01
Paradoxical-activation-of-RAF-signaling-by-kinase-inactive-BRAF	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Signaling-by-RAS-mutants	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Signaling-by-moderate-kinase-activity-BRAF-mutants	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Signaling-downstream-of-RAS-mutants	43	2.82e-01	4.59e-01	0.17700	1.10e-01	-0.139000	2.14e-01	1.16e-01
Leishmania-infection	233	2.83e-01	4.59e-01	0.06710	-3.17e-02	0.059200	4.03e-01	1.19e-01
Transport-of-Ribonucleoproteins-into-the-Host-Nucleus	30	2.83e-01	4.59e-01	0.11800	1.18e-01	0.006300	2.64e-01	9.52e-01
Signaling-by-cytosolic-FGFR1-fusion-mutants	17	2.83e-01	4.59e-01	0.12600	-7.86e-02	-0.097900	5.75e-01	4.84e-01
PI-3K-cascade:FGFR2	18	2.85e-01	4.62e-01	0.17000	1.82e-02	-0.169000	8.94e-01	2.14e-01
HIV-Infection	214	2.86e-01	4.62e-01	0.08130	5.58e-02	-0.059100	1.59e-01	1.36e-01
Signaling-by-FGFR3-fusions-in-cancer	10	2.86e-01	4.62e-01	0.23800	3.85e-02	-0.235000	8.33e-01	1.98e-01
TAK1-activates-NFkB-by-phosphorylation-and-activation-of-IKKs-complex	24	2.88e-01	4.65e-01	0.23400	1.44e-01	-0.184000	2.23e-01	1.18e-01
NF-kB-is-activated-and-signals-survival	12	2.89e-01	4.65e-01	0.30400	1.56e-01	-0.261000	3.50e-01	1.17e-01
Apoptosis	159	2.90e-01	4.66e-01	0.09120	5.65e-02	-0.071500	2.18e-01	1.19e-01
Nuclear-Envelope-Breakdown	51	2.93e-01	4.71e-01	0.08970	8.96e-02	0.004190	2.68e-01	9.59e-01
RAB-geranylgeranylation	63	2.93e-01	4.71e-01	0.14800	1.07e-01	-0.102000	1.42e-01	1.61e-01
Signaling-by-FGFR2	66	2.93e-01	4.71e-01	0.11600	4.71e-02	-0.106000	5.08e-01	1.37e-01
Signaling-by-BRAF-and-RAF1-fusions	62	2.94e-01	4.71e-01	0.14900	1.08e-01	-0.102000	1.40e-01	1.64e-01
CTLA4-inhibitory-signaling	21	2.96e-01	4.74e-01	0.11800	1.09e-01	0.044600	3.86e-01	7.24e-01
Aquaporin-mediated-transport	47	2.97e-01	4.74e-01	0.10200	1.02e-01	-0.008850	2.28e-01	9.16e-01
Glycosphingolipid-metabolism	39	2.97e-01	4.74e-01	0.15600	-6.91e-02	0.140000	4.55e-01	1.31e-01
SHC1-events-in-ERBB2-signaling	22	2.97e-01	4.74e-01	0.14800	1.22e-02	-0.148000	9.21e-01	2.30e-01
Interleukin-4-and-Interleukin-13-signaling	101	2.97e-01	4.74e-01	0.11200	-6.78e-02	0.089100	2.39e-01	1.21e-01
Synthesis-of-IP3-and-IP4-in-the-cytosol	25	2.99e-01	4.76e-01	0.13700	-8.51e-03	0.136000	9.41e-01	2.37e-01
G0-and-Early-G1	26	2.99e-01	4.76e-01	0.22500	1.71e-01	-0.147000	1.31e-01	1.96e-01
Regulation-of-TNFR1-signaling	33	3.00e-01	4.76e-01	0.12100	1.06e-02	-0.121000	9.16e-01	2.30e-01
Nuclear-import-of-Rev-protein	31	3.00e-01	4.76e-01	0.09050	6.58e-02	0.062200	5.26e-01	5.49e-01
Downstream-signaling-of-activated-FGFR1	26	3.00e-01	4.76e-01	0.14300	-1.41e-01	0.020400	2.12e-01	8.57e-01
Signaling-by-FGFR1	43	3.05e-01	4.83e-01	0.08220	-7.70e-02	-0.028900	3.82e-01	7.43e-01
Activation-of-RAC1	13	3.06e-01	4.84e-01	0.20800	-2.04e-01	0.038800	2.03e-01	8.09e-01
Signaling-by-Type-1-Insulin-like-Growth-Factor-1-Receptor-(IGF1R)	48	3.07e-01	4.86e-01	0.07210	-5.42e-02	-0.047600	5.16e-01	5.68e-01
IRS-related-events-triggered-by-IGF1R	46	3.08e-01	4.86e-01	0.07350	-5.03e-02	-0.053600	5.55e-01	5.29e-01
Host-Interactions-of-HIV-factors	121	3.10e-01	4.89e-01	0.07830	2.67e-02	-0.073600	6.11e-01	1.62e-01
Nicotinate-metabolism	29	3.10e-01	4.89e-01	0.11800	-2.32e-03	-0.118000	9.83e-01	2.71e-01
TICAM1-dependent-activation-of-IRF3/IRF7	11	3.12e-01	4.91e-01	0.15600	-1.39e-01	-0.070500	4.26e-01	6.86e-01
Interconversion-of-nucleotide-di–and-triphosphates	27	3.12e-01	4.91e-01	0.14600	3.06e-02	-0.143000	7.83e-01	2.00e-01
Mitotic-Prophase	81	3.13e-01	4.91e-01	0.09730	9.07e-02	-0.035200	1.58e-01	5.84e-01
Nonhomologous-End-Joining-(NHEJ)	34	3.14e-01	4.93e-01	0.18400	-1.05e-01	0.151000	2.88e-01	1.28e-01
IGF1R-signaling-cascade	47	3.15e-01	4.93e-01	0.07420	-6.46e-02	-0.036500	4.44e-01	6.65e-01
Cytochrome-c-mediated-apoptotic-response	11	3.17e-01	4.96e-01	0.16000	5.63e-02	0.150000	7.46e-01	3.90e-01
DCC-mediated-attractive-signaling	13	3.17e-01	4.96e-01	0.30300	-1.83e-01	0.241000	2.53e-01	1.32e-01
DSCAM-interactions	10	3.18e-01	4.97e-01	0.27700	-1.03e-01	0.257000	5.74e-01	1.59e-01
Metabolism-of-cofactors	19	3.19e-01	4.98e-01	0.23700	-2.00e-01	0.127000	1.31e-01	3.37e-01
RNA-Polymerase-III-Transcription-Termination	23	3.20e-01	4.99e-01	0.17100	5.27e-02	-0.163000	6.62e-01	1.76e-01
Translation-of-Replicase-and-Assembly-of-the-Replication-Transcription-Complex	12	3.21e-01	5.00e-01	0.25400	2.35e-01	-0.096100	1.58e-01	5.64e-01
Transcriptional-regulation-of-pluripotent-stem-cells	24	3.25e-01	5.04e-01	0.18600	7.83e-02	-0.169000	5.06e-01	1.51e-01
Recycling-of-bile-acids-and-salts	15	3.25e-01	5.04e-01	0.19200	4.04e-02	-0.188000	7.86e-01	2.07e-01
Regulation-of-TP53-Activity-through-Acetylation	30	3.25e-01	5.04e-01	0.20200	-1.30e-01	0.155000	2.17e-01	1.43e-01
RET-signaling	40	3.26e-01	5.04e-01	0.17000	-1.36e-01	0.101000	1.35e-01	2.68e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE	27	3.27e-01	5.04e-01	0.10900	1.07e-01	0.019200	3.34e-01	8.63e-01
RNA-Pol-II-CTD-phosphorylation-and-interaction-with-CE-during-HIV-infection	27	3.27e-01	5.04e-01	0.10900	1.07e-01	0.019200	3.34e-01	8.63e-01
Cargo-recognition-for-clathrin-mediated-endocytosis	96	3.27e-01	5.04e-01	0.07730	1.78e-02	-0.075200	7.63e-01	2.03e-01
ATF4-activates-genes-in-response-to-endoplasmic-reticulum–stress	24	3.27e-01	5.04e-01	0.13000	1.67e-03	-0.130000	9.89e-01	2.71e-01
G-beta:gamma-signalling-through-CDC42	19	3.27e-01	5.04e-01	0.15500	1.55e-01	-0.015600	2.43e-01	9.06e-01
CLEC7A-(Dectin-1)-induces-NFAT-activation	11	3.28e-01	5.04e-01	0.30300	2.59e-01	-0.158000	1.37e-01	3.65e-01
Deposition-of-new-CENPA-containing-nucleosomes-at-the-centromere	25	3.28e-01	5.04e-01	0.22400	1.53e-01	-0.163000	1.84e-01	1.59e-01
Nucleosome-assembly	25	3.28e-01	5.04e-01	0.22400	1.53e-01	-0.163000	1.84e-01	1.59e-01
Keratan-sulfate/keratin-metabolism	29	3.29e-01	5.05e-01	0.16400	-6.44e-02	0.151000	5.48e-01	1.60e-01
Regulation-of-actin-dynamics-for-phagocytic-cup-formation	71	3.30e-01	5.06e-01	0.08910	-8.68e-02	0.020100	2.06e-01	7.69e-01
Nucleotide-binding-domain,-leucine-rich-repeat-containing-receptor-(NLR)-signaling-pathways	50	3.31e-01	5.08e-01	0.11900	-1.11e-01	0.040800	1.73e-01	6.18e-01
Negative-regulation-of-TCF-dependent-signaling-by-WNT-ligand-antagonists	14	3.34e-01	5.12e-01	0.24400	-1.05e-01	0.220000	4.96e-01	1.54e-01
Cytokine-Signaling-in-Immune-system	606	3.34e-01	5.12e-01	0.02150	-2.04e-02	-0.006810	3.89e-01	7.74e-01
DARPP-32-events	23	3.35e-01	5.13e-01	0.21400	1.78e-01	-0.119000	1.39e-01	3.24e-01
MAP2K-and-MAPK-activation	38	3.36e-01	5.13e-01	0.16700	1.38e-01	-0.093000	1.40e-01	3.21e-01
Recruitment-of-NuMA-to-mitotic-centrosomes	77	3.36e-01	5.13e-01	0.09690	9.03e-02	-0.035400	1.71e-01	5.92e-01
Regulation-of-Complement-cascade	49	3.37e-01	5.13e-01	0.08070	-7.98e-02	-0.012500	3.34e-01	8.79e-01
Biosynthesis-of-DHA-derived-SPMs	15	3.37e-01	5.13e-01	0.12400	7.76e-02	0.097000	6.03e-01	5.15e-01
Synthesis-of-glycosylphosphatidylinositol-(GPI)	18	3.37e-01	5.13e-01	0.11400	-6.59e-02	-0.093200	6.28e-01	4.94e-01
Interleukin-15-signaling	13	3.37e-01	5.13e-01	0.29400	-2.35e-01	0.177000	1.42e-01	2.70e-01
Defective-HDR-through-Homologous-Recombination-(HRR)-due-to-PALB2-loss-of-function	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Defective-HDR-through-Homologous-Recombination-Repair-(HRR)-due-to-PALB2-loss-of-BRCA1-binding-function	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Defective-HDR-through-Homologous-Recombination-Repair-(HRR)-due-to-PALB2-loss-of-BRCA2/RAD51/RAD51C-binding-function	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Diseases-of-DNA-Double-Strand-Break-Repair	24	3.40e-01	5.15e-01	0.11700	1.17e-01	0.013600	3.23e-01	9.08e-01
Purine-ribonucleoside-monophosphate-biosynthesis	12	3.41e-01	5.15e-01	0.18500	1.85e-01	-0.009460	2.68e-01	9.55e-01
SHC1-events-in-ERBB4-signaling	14	3.41e-01	5.15e-01	0.28500	1.77e-01	-0.224000	2.52e-01	1.47e-01
IRS-mediated-signalling	42	3.46e-01	5.22e-01	0.07380	-6.02e-02	-0.042700	5.00e-01	6.32e-01
Nuclear-signaling-by-ERBB4	31	3.46e-01	5.22e-01	0.19400	1.47e-01	-0.126000	1.56e-01	2.25e-01
Signaling-by-NOTCH	172	3.47e-01	5.23e-01	0.08050	-6.38e-02	0.049200	1.49e-01	2.66e-01
Thromboxane-signalling-through-TP-receptor	23	3.48e-01	5.23e-01	0.11400	2.11e-02	0.112000	8.61e-01	3.51e-01
JNK-(c-Jun-kinases)-phosphorylation-and–activation-mediated-by-activated-human-TAK1	17	3.51e-01	5.27e-01	0.26300	1.83e-01	-0.189000	1.92e-01	1.78e-01
Rev-mediated-nuclear-export-of-HIV-RNA	33	3.52e-01	5.27e-01	0.09240	2.19e-02	0.089800	8.28e-01	3.72e-01
Notch-HLH-transcription-pathway	27	3.52e-01	5.27e-01	0.18100	-8.84e-02	0.158000	4.26e-01	1.54e-01
p38MAPK-events	13	3.52e-01	5.27e-01	0.17300	1.72e-01	-0.005500	2.82e-01	9.73e-01
HDR-through-Homologous-Recombination-(HRR)-or-Single-Strand-Annealing-(SSA)	94	3.54e-01	5.30e-01	0.06560	6.55e-02	-0.004220	2.72e-01	9.44e-01
Caspase-mediated-cleavage-of-cytoskeletal-proteins	12	3.54e-01	5.30e-01	0.14500	5.13e-02	0.136000	7.58e-01	4.15e-01
PI3K-Cascade	38	3.55e-01	5.30e-01	0.09540	-9.53e-02	-0.004490	3.09e-01	9.62e-01
Signaling-by-high-kinase-activity-BRAF-mutants	34	3.57e-01	5.33e-01	0.17000	1.42e-01	-0.093900	1.51e-01	3.43e-01
PTK6-Regulates-RHO-GTPases,-RAS-GTPase-and-MAP-kinases	13	3.58e-01	5.34e-01	0.19800	-4.22e-02	0.193000	7.92e-01	2.27e-01
G-alpha-(z)-signalling-events	46	3.59e-01	5.34e-01	0.14700	-8.14e-02	0.122000	3.39e-01	1.52e-01
Nuclear-events-stimulated-by-ALK-signaling-in-cancer	17	3.64e-01	5.42e-01	0.25800	1.83e-01	-0.182000	1.90e-01	1.94e-01
Phospholipase-C-mediated-cascade;-FGFR4	12	3.65e-01	5.42e-01	0.16500	-1.15e-02	-0.165000	9.45e-01	3.24e-01
Resolution-of-D-loop-Structures-through-Holliday-Junction-Intermediates	32	3.66e-01	5.43e-01	0.09080	8.75e-02	0.024200	3.91e-01	8.13e-01
PTEN-Regulation	136	3.66e-01	5.43e-01	0.04140	-3.73e-02	-0.018000	4.52e-01	7.17e-01
G-protein-activation	21	3.67e-01	5.43e-01	0.11200	3.05e-02	0.107000	8.09e-01	3.94e-01
Acyl-chain-remodelling-of-PE	21	3.67e-01	5.43e-01	0.22500	1.77e-01	-0.140000	1.61e-01	2.67e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-G1-Cell-Cycle-Arrest	13	3.67e-01	5.43e-01	0.24400	2.19e-01	-0.107000	1.71e-01	5.02e-01
Listeria-monocytogenes-entry-into-host-cells	18	3.67e-01	5.43e-01	0.24700	-1.87e-01	0.162000	1.70e-01	2.34e-01
Synthesis-of-PC	27	3.69e-01	5.45e-01	0.20300	1.48e-01	-0.140000	1.84e-01	2.08e-01
Loss-of-Nlp-from-mitotic-centrosomes	67	3.71e-01	5.47e-01	0.11500	9.87e-02	-0.059000	1.62e-01	4.04e-01
Loss-of-proteins-required-for-interphase-microtubule-organization-from-the-centrosome	67	3.71e-01	5.47e-01	0.11500	9.87e-02	-0.059000	1.62e-01	4.04e-01
Transcriptional-activation-of-mitochondrial-biogenesis	51	3.72e-01	5.48e-01	0.08690	-8.67e-02	0.005590	2.84e-01	9.45e-01
Export-of-Viral-Ribonucleoproteins-from-Nucleus	31	3.74e-01	5.50e-01	0.08460	7.44e-02	0.040200	4.73e-01	6.99e-01
Attenuation-phase	22	3.75e-01	5.51e-01	0.14100	-1.40e-01	0.021800	2.57e-01	8.59e-01
Retrograde-transport-at-the-Trans-Golgi-Network	46	3.75e-01	5.51e-01	0.14000	1.19e-01	-0.073800	1.63e-01	3.86e-01
WNT5A-dependent-internalization-of-FZD4	15	3.77e-01	5.53e-01	0.14800	-1.48e-01	-0.005560	3.21e-01	9.70e-01
Regulation-of-FZD-by-ubiquitination	19	3.78e-01	5.53e-01	0.23300	1.44e-01	-0.183000	2.77e-01	1.67e-01
Signaling-by-EGFR	48	3.80e-01	5.56e-01	0.07420	-7.23e-02	-0.016700	3.86e-01	8.42e-01
FGFR4-ligand-binding-and-activation	11	3.80e-01	5.56e-01	0.13600	-1.02e-01	-0.090500	5.59e-01	6.03e-01
IRAK4-deficiency-(TLR2/4)	17	3.82e-01	5.58e-01	0.22500	1.16e-01	-0.193000	4.08e-01	1.68e-01
Disassembly-of-the-destruction-complex-and-recruitment-of-AXIN-to-the-membrane	29	3.84e-01	5.60e-01	0.08680	7.73e-02	0.039400	4.71e-01	7.13e-01
mRNA-Capping	29	3.85e-01	5.61e-01	0.08690	3.87e-02	0.077800	7.19e-01	4.68e-01
HSF1-activation	25	3.86e-01	5.61e-01	0.10400	-1.02e-01	-0.020100	3.79e-01	8.62e-01
Interleukin-37-signaling	20	3.86e-01	5.62e-01	0.10200	-5.72e-02	-0.083800	6.58e-01	5.16e-01
Effects-of-PIP2-hydrolysis	26	3.87e-01	5.62e-01	0.08880	5.09e-02	0.072700	6.53e-01	5.21e-01
Late-Phase-of-HIV-Life-Cycle	125	3.87e-01	5.62e-01	0.08180	7.06e-02	-0.041200	1.72e-01	4.25e-01
HCMV-Early-Events	57	3.87e-01	5.62e-01	0.10400	-3.69e-02	0.097200	6.30e-01	2.04e-01
Insulin-processing	26	3.88e-01	5.62e-01	0.08880	7.32e-02	0.050200	5.18e-01	6.58e-01
Dectin-2-family	20	3.90e-01	5.65e-01	0.14700	1.45e-01	-0.025100	2.61e-01	8.46e-01
Downregulation-of-ERBB2:ERBB3-signaling	12	3.92e-01	5.67e-01	0.25900	1.27e-01	-0.225000	4.44e-01	1.77e-01
Infection-with-Mycobacterium-tuberculosis	25	3.92e-01	5.67e-01	0.20100	1.28e-01	-0.155000	2.67e-01	1.79e-01
G-beta:gamma-signalling-through-BTK	17	3.93e-01	5.67e-01	0.10800	7.87e-02	0.073400	5.74e-01	6.00e-01
Platelet-Adhesion-to-exposed-collagen	13	3.94e-01	5.68e-01	0.16600	8.99e-03	-0.165000	9.55e-01	3.02e-01
Thrombin-signalling-through-proteinase-activated-receptors-(PARs)	31	3.95e-01	5.69e-01	0.12700	-3.29e-02	0.123000	7.51e-01	2.37e-01
NS1-Mediated-Effects-on-Host-Pathways	36	3.96e-01	5.70e-01	0.12500	1.18e-01	-0.040100	2.19e-01	6.77e-01
TNF-signaling	42	3.97e-01	5.70e-01	0.13300	6.13e-02	-0.118000	4.91e-01	1.85e-01
Plasma-lipoprotein-clearance	33	3.97e-01	5.70e-01	0.14300	5.85e-02	-0.130000	5.61e-01	1.96e-01
TRAF6-mediated-IRF7-activation	15	3.98e-01	5.70e-01	0.13700	-1.67e-02	-0.136000	9.11e-01	3.63e-01
Striated-Muscle-Contraction	32	3.98e-01	5.70e-01	0.15100	1.35e-01	-0.068200	1.87e-01	5.04e-01
Nucleotide-salvage	22	3.98e-01	5.70e-01	0.21300	1.35e-01	-0.164000	2.72e-01	1.83e-01
Ca2+-pathway	60	3.99e-01	5.70e-01	0.09940	-3.48e-02	0.093100	6.41e-01	2.12e-01
G-protein-beta:gamma-signalling	30	4.00e-01	5.70e-01	0.14900	-6.07e-02	0.136000	5.65e-01	1.98e-01
Signaling-by-RAF1-mutants	39	4.00e-01	5.70e-01	0.15600	9.36e-02	-0.125000	3.12e-01	1.77e-01
Olfactory-Signaling-Pathway	37	4.00e-01	5.71e-01	0.14000	1.25e-01	-0.063000	1.89e-01	5.07e-01
FGFR2-mutant-receptor-activation	28	4.01e-01	5.72e-01	0.18900	1.24e-01	-0.143000	2.57e-01	1.90e-01
Pregnenolone-biosynthesis	12	4.02e-01	5.72e-01	0.26000	1.34e-01	-0.223000	4.23e-01	1.80e-01
TNF-receptor-superfamily-(TNFSF)-members-mediating-non-canonical-NF-kB-pathway	17	4.05e-01	5.76e-01	0.20400	-9.06e-02	0.182000	5.18e-01	1.93e-01
Transport-of-organic-anions	10	4.07e-01	5.78e-01	0.19200	-1.91e-01	0.019000	2.96e-01	9.17e-01
Metabolism-of-nitric-oxide:-NOS3-activation-and-regulation	15	4.07e-01	5.78e-01	0.13300	-1.31e-01	-0.020400	3.80e-01	8.91e-01
Aggrephagy	21	4.08e-01	5.78e-01	0.11100	-1.95e-02	-0.109000	8.77e-01	3.87e-01
Telomere-C-strand-synthesis-initiation	13	4.10e-01	5.80e-01	0.27700	-2.01e-01	0.190000	2.08e-01	2.34e-01
NGF-stimulated-transcription	39	4.10e-01	5.80e-01	0.10400	-1.02e-01	0.019500	2.69e-01	8.33e-01
Miscellaneous-transport-and-binding-events	23	4.10e-01	5.80e-01	0.16700	-6.81e-02	0.153000	5.72e-01	2.05e-01
Transcriptional-regulation-by-the-AP-2-(TFAP2)-family-of-transcription-factors	32	4.12e-01	5.82e-01	0.17600	1.18e-01	-0.130000	2.48e-01	2.03e-01
Death-Receptor-Signalling	132	4.13e-01	5.82e-01	0.06650	6.21e-02	-0.024000	2.18e-01	6.34e-01
Voltage-gated-Potassium-channels	38	4.13e-01	5.82e-01	0.12400	1.15e-01	-0.044300	2.19e-01	6.36e-01
Sphingolipid-metabolism	81	4.16e-01	5.86e-01	0.07940	-7.58e-02	0.023600	2.38e-01	7.13e-01
mRNA-decay-by-5’-to-3’-exoribonuclease	15	4.17e-01	5.87e-01	0.15300	1.29e-02	-0.152000	9.31e-01	3.07e-01
Regulation-of-pyruvate-dehydrogenase-(PDH)-complex	15	4.18e-01	5.87e-01	0.21100	9.24e-02	-0.190000	5.35e-01	2.02e-01
Translation-of-Structural-Proteins	28	4.21e-01	5.90e-01	0.18400	-1.20e-01	0.140000	2.72e-01	2.00e-01
Vpr-mediated-nuclear-import-of-PICs	32	4.21e-01	5.90e-01	0.10700	1.06e-01	-0.013000	2.98e-01	8.99e-01
EPH-ephrin-mediated-repulsion-of-cells	44	4.21e-01	5.90e-01	0.06440	4.31e-02	0.047900	6.21e-01	5.83e-01
Transport-of-nucleosides-and-free-purine-and-pyrimidine-bases-across-the-plasma-membrane	10	4.22e-01	5.90e-01	0.29200	2.40e-01	-0.166000	1.89e-01	3.62e-01
Activated-point-mutants-of-FGFR2	12	4.22e-01	5.90e-01	0.19900	5.42e-02	-0.192000	7.45e-01	2.50e-01
Metabolism-of-nucleotides	93	4.22e-01	5.90e-01	0.10100	7.64e-02	-0.066200	2.03e-01	2.69e-01
Metabolism-of-vitamins-and-cofactors	168	4.25e-01	5.93e-01	0.04900	-4.82e-02	0.008800	2.81e-01	8.44e-01
Syndecan-interactions	20	4.28e-01	5.98e-01	0.10300	3.38e-02	0.097000	7.94e-01	4.53e-01
Carnitine-metabolism	12	4.29e-01	5.98e-01	0.12200	-7.63e-02	-0.095800	6.47e-01	5.65e-01
EPHA-mediated-growth-cone-collapse	14	4.32e-01	6.02e-01	0.23700	2.00e-01	-0.128000	1.96e-01	4.08e-01
VEGFR2-mediated-vascular-permeability	26	4.33e-01	6.02e-01	0.18400	-1.46e-01	0.112000	1.99e-01	3.21e-01
Peptide-ligand-binding-receptors	146	4.37e-01	6.08e-01	0.06360	-2.53e-02	0.058300	5.97e-01	2.24e-01
Signal-transduction-by-L1	21	4.37e-01	6.08e-01	0.19600	1.10e-01	-0.162000	3.82e-01	1.98e-01
Presynaptic-function-of-Kainate-receptors	20	4.39e-01	6.09e-01	0.14900	-3.90e-02	0.144000	7.63e-01	2.65e-01
SUMOylation-of-transcription-factors	18	4.40e-01	6.10e-01	0.15500	-3.83e-02	0.150000	7.79e-01	2.70e-01
Regulation-of-TP53-Activity-through-Methylation	17	4.42e-01	6.12e-01	0.15800	1.54e-01	-0.037900	2.73e-01	7.87e-01
Aberrant-regulation-of-mitotic-exit-in-cancer-due-to-RB1-defects	20	4.42e-01	6.12e-01	0.21300	1.42e-01	-0.158000	2.71e-01	2.20e-01
Ion-transport-by-P-type-ATPases	53	4.45e-01	6.15e-01	0.06090	5.69e-02	0.021900	4.74e-01	7.82e-01
SUMOylation-of-immune-response-proteins	11	4.46e-01	6.16e-01	0.28600	2.11e-01	-0.192000	2.25e-01	2.70e-01
InlB-mediated-entry-of-Listeria-monocytogenes-into-host-cell	14	4.48e-01	6.18e-01	0.15700	-1.56e-01	0.020200	3.13e-01	8.96e-01
Signaling-by-Activin	13	4.50e-01	6.20e-01	0.25300	2.01e-01	-0.154000	2.09e-01	3.37e-01
Activated-NTRK2-signals-through-FRS2-and-FRS3	11	4.50e-01	6.20e-01	0.16600	-8.58e-03	0.166000	9.61e-01	3.40e-01
mRNA-Splicing—Minor-Pathway	53	4.52e-01	6.22e-01	0.08620	1.83e-02	-0.084200	8.17e-01	2.89e-01
Insulin-receptor-signalling-cascade	48	4.54e-01	6.24e-01	0.05900	-4.44e-02	-0.038900	5.95e-01	6.41e-01
SHC1-events-in-EGFR-signaling	13	4.55e-01	6.25e-01	0.24000	1.31e-01	-0.201000	4.13e-01	2.10e-01
Diseases-associated-with-N-glycosylation-of-proteins	16	4.55e-01	6.25e-01	0.18400	-1.70e-01	0.070800	2.39e-01	6.24e-01
MyD88-deficiency-(TLR2/4)	16	4.56e-01	6.26e-01	0.18400	7.12e-02	-0.170000	6.22e-01	2.39e-01
Nephrin-family-interactions	22	4.60e-01	6.30e-01	0.12200	1.21e-01	-0.013700	3.26e-01	9.11e-01
Inactivation,-recovery-and-regulation-of-the-phototransduction-cascade	30	4.62e-01	6.31e-01	0.13200	4.89e-02	-0.122000	6.43e-01	2.47e-01
The-phototransduction-cascade	30	4.62e-01	6.31e-01	0.13200	4.89e-02	-0.122000	6.43e-01	2.47e-01
NRIF-signals-cell-death-from-the-nucleus	15	4.66e-01	6.37e-01	0.22100	1.22e-01	-0.184000	4.13e-01	2.17e-01
EGFR-downregulation	29	4.67e-01	6.38e-01	0.07440	-5.41e-02	-0.051000	6.14e-01	6.34e-01
G-beta:gamma-signalling-through-PLC-beta	19	4.68e-01	6.38e-01	0.13600	-2.39e-02	0.134000	8.57e-01	3.11e-01
Interleukin-17-signaling	68	4.69e-01	6.38e-01	0.11200	8.07e-02	-0.077400	2.50e-01	2.69e-01
Synthesis-of-PIPs-at-the-Golgi-membrane	17	4.69e-01	6.38e-01	0.12500	1.23e-03	0.125000	9.93e-01	3.73e-01
Estrogen-dependent-gene-expression	90	4.71e-01	6.40e-01	0.07330	-6.87e-02	0.025600	2.59e-01	6.75e-01
Phenylalanine-and-tyrosine-metabolism	10	4.72e-01	6.40e-01	0.14300	-3.27e-02	-0.139000	8.58e-01	4.46e-01
RHO-GTPases-activate-PAKs	21	4.72e-01	6.40e-01	0.12700	1.25e-01	-0.019400	3.21e-01	8.78e-01
FGFR2-ligand-binding-and-activation	14	4.74e-01	6.42e-01	0.17100	4.54e-02	-0.165000	7.69e-01	2.86e-01
RUNX2-regulates-osteoblast-differentiation	24	4.76e-01	6.44e-01	0.08980	8.63e-02	0.024700	4.64e-01	8.34e-01
CS/DS-degradation	13	4.77e-01	6.45e-01	0.23100	-1.24e-01	0.195000	4.39e-01	2.25e-01
Myogenesis	24	4.77e-01	6.45e-01	0.18000	-1.10e-01	0.142000	3.51e-01	2.27e-01
Spry-regulation-of-FGF-signaling	15	4.77e-01	6.45e-01	0.13900	1.39e-01	-0.009730	3.52e-01	9.48e-01
NOTCH3-Activation-and-Transmission-of-Signal-to-the-Nucleus	24	4.78e-01	6.45e-01	0.15700	-1.39e-01	0.071300	2.37e-01	5.46e-01
Processive-synthesis-on-the-lagging-strand	15	4.78e-01	6.45e-01	0.11100	3.55e-02	0.105000	8.12e-01	4.81e-01
Neurotransmitter-clearance	10	4.79e-01	6.45e-01	0.24000	2.15e-01	-0.107000	2.40e-01	5.58e-01
Chondroitin-sulfate-biosynthesis	19	4.80e-01	6.46e-01	0.20300	-1.27e-01	0.159000	3.38e-01	2.32e-01
HCMV-Infection	79	4.82e-01	6.48e-01	0.05760	5.76e-02	-0.000387	3.76e-01	9.95e-01
Diseases-associated-with-visual-transduction	12	4.83e-01	6.48e-01	0.25400	1.59e-01	-0.199000	3.41e-01	2.33e-01
Diseases-of-the-neuronal-system	12	4.83e-01	6.48e-01	0.25400	1.59e-01	-0.199000	3.41e-01	2.33e-01
Retinoid-cycle-disease-events	12	4.83e-01	6.48e-01	0.25400	1.59e-01	-0.199000	3.41e-01	2.33e-01
MTOR-signalling	41	4.83e-01	6.48e-01	0.09280	9.09e-02	-0.018700	3.14e-01	8.36e-01
Post-chaperonin-tubulin-folding-pathway	17	4.84e-01	6.48e-01	0.10900	1.07e-01	0.022200	4.46e-01	8.74e-01
MAP-kinase-activation	61	4.85e-01	6.49e-01	0.10800	6.20e-02	-0.089000	4.02e-01	2.29e-01
VLDLR-internalisation-and-degradation	12	4.86e-01	6.49e-01	0.11300	9.06e-02	0.068200	5.87e-01	6.83e-01
Amyloid-fiber-formation	44	4.88e-01	6.52e-01	0.09320	-2.35e-02	0.090200	7.87e-01	3.00e-01
Mitochondrial-iron-sulfur-cluster-biogenesis	13	4.90e-01	6.54e-01	0.17500	1.68e-01	-0.049100	2.93e-01	7.59e-01
Detoxification-of-Reactive-Oxygen-Species	34	4.90e-01	6.54e-01	0.06940	-3.07e-02	-0.062300	7.57e-01	5.30e-01
Signaling-by-FGFR4	37	4.92e-01	6.55e-01	0.10200	2.63e-02	-0.098200	7.82e-01	3.01e-01
Prolonged-ERK-activation-events	14	4.93e-01	6.56e-01	0.16700	-1.61e-01	0.045500	2.98e-01	7.68e-01
SHC-mediated-cascade:FGFR2	18	4.95e-01	6.57e-01	0.18100	8.71e-02	-0.159000	5.22e-01	2.44e-01
Protein-folding	89	4.95e-01	6.57e-01	0.08720	4.82e-02	-0.072600	4.31e-01	2.36e-01
Aflatoxin-activation-and-detoxification	16	4.95e-01	6.57e-01	0.20700	-1.17e-01	0.171000	4.19e-01	2.36e-01
NEP/NS2-Interacts-with-the-Cellular-Export-Machinery	30	4.96e-01	6.58e-01	0.07020	4.75e-02	0.051600	6.52e-01	6.24e-01
Complement-cascade	57	4.97e-01	6.58e-01	0.05880	-5.77e-02	-0.011400	4.51e-01	8.82e-01
Diseases-of-carbohydrate-metabolism	30	5.01e-01	6.62e-01	0.10000	-9.92e-02	0.013600	3.47e-01	8.98e-01
cGMP-effects	15	5.01e-01	6.62e-01	0.22000	1.74e-01	-0.135000	2.44e-01	3.66e-01
Processing-and-activation-of-SUMO	10	5.02e-01	6.62e-01	0.26500	-2.14e-01	0.155000	2.41e-01	3.95e-01
Translesion-Synthesis-by-POLH	18	5.03e-01	6.63e-01	0.20300	1.57e-01	-0.130000	2.50e-01	3.40e-01
Protein-methylation	14	5.03e-01	6.63e-01	0.23500	1.65e-01	-0.167000	2.84e-01	2.80e-01
Free-fatty-acids-regulate-insulin-secretion	11	5.04e-01	6.64e-01	0.25600	-2.02e-01	0.157000	2.46e-01	3.67e-01
CD28-dependent-Vav1-pathway	12	5.05e-01	6.64e-01	0.25300	-1.73e-01	0.184000	2.99e-01	2.70e-01
The-canonical-retinoid-cycle-in-rods-(twilight-vision)	19	5.05e-01	6.64e-01	0.13800	3.48e-02	-0.134000	7.93e-01	3.13e-01
YAP1–and-WWTR1-(TAZ)-stimulated-gene-expression	12	5.06e-01	6.64e-01	0.13600	-1.36e-01	-0.008520	4.15e-01	9.59e-01
Metabolism-of-non-coding-RNA	50	5.06e-01	6.64e-01	0.12200	-7.81e-02	0.093400	3.39e-01	2.53e-01
snRNP-Assembly	50	5.06e-01	6.64e-01	0.12200	-7.81e-02	0.093400	3.39e-01	2.53e-01
Caspase-activation-via-Death-Receptors-in-the-presence-of-ligand	15	5.07e-01	6.64e-01	0.10500	-9.78e-02	-0.037900	5.12e-01	8.00e-01
RHOJ-GTPase-cycle	55	5.08e-01	6.65e-01	0.11100	-6.34e-02	0.090700	4.16e-01	2.45e-01
Regulated-proteolysis-of-p75NTR	11	5.09e-01	6.66e-01	0.20700	1.90e-01	-0.080400	2.74e-01	6.44e-01
SUMOylation-of-DNA-replication-proteins	44	5.10e-01	6.67e-01	0.09150	8.82e-02	-0.024400	3.11e-01	7.79e-01
Meiotic-recombination	27	5.17e-01	6.75e-01	0.08740	8.70e-02	0.008600	4.34e-01	9.38e-01
RUNX1-regulates-genes-involved-in-megakaryocyte-differentiation-and-platelet-function	37	5.18e-01	6.75e-01	0.12300	-1.07e-01	0.060200	2.58e-01	5.26e-01
Regulation-of-TP53-Activity-through-Association-with-Co-factors	13	5.18e-01	6.75e-01	0.19600	1.77e-01	-0.084300	2.70e-01	5.98e-01
Uptake-and-actions-of-bacterial-toxins	29	5.19e-01	6.75e-01	0.07110	-3.50e-02	-0.061900	7.44e-01	5.64e-01
Class-C/3-(Metabotropic-glutamate/pheromone-receptors)	21	5.21e-01	6.78e-01	0.09850	9.75e-03	0.098000	9.38e-01	4.37e-01
Transcriptional-regulation-of-granulopoiesis	31	5.22e-01	6.78e-01	0.14400	-8.26e-02	0.118000	4.26e-01	2.54e-01
TP53-Regulates-Transcription-of-Genes-Involved-in-Cytochrome-C-Release	18	5.22e-01	6.78e-01	0.13300	1.31e-01	-0.028000	3.38e-01	8.37e-01
Interleukin-20-family-signaling	19	5.23e-01	6.78e-01	0.15400	-1.42e-01	0.059300	2.85e-01	6.54e-01
TNFR1-induced-NFkappaB-signaling-pathway	25	5.23e-01	6.78e-01	0.16800	1.28e-01	-0.108000	2.66e-01	3.48e-01
Initial-triggering-of-complement	28	5.24e-01	6.78e-01	0.14200	-1.23e-01	0.071300	2.60e-01	5.14e-01
Mitochondrial-calcium-ion-transport	22	5.24e-01	6.78e-01	0.16100	8.09e-02	-0.139000	5.11e-01	2.60e-01
Biosynthesis-of-specialized-proresolving-mediators-(SPMs)	17	5.26e-01	6.79e-01	0.09320	8.36e-02	0.041100	5.50e-01	7.69e-01
Synthesis-of-PIPs-at-the-early-endosome-membrane	16	5.26e-01	6.79e-01	0.17800	-8.06e-02	0.159000	5.77e-01	2.71e-01
Formation-of-RNA-Pol-II-elongation-complex	54	5.27e-01	6.79e-01	0.05030	3.13e-02	0.039300	6.90e-01	6.17e-01
RNA-Polymerase-II-Transcription-Elongation	54	5.27e-01	6.79e-01	0.05030	3.13e-02	0.039300	6.90e-01	6.17e-01
Negative-regulation-of-FGFR2-signaling	28	5.31e-01	6.84e-01	0.15900	1.14e-01	-0.111000	2.94e-01	3.10e-01
Selective-autophagy	59	5.31e-01	6.84e-01	0.10600	6.48e-02	-0.084000	3.89e-01	2.64e-01
PI-3K-cascade:FGFR1	16	5.32e-01	6.84e-01	0.13600	-1.34e-01	0.024600	3.54e-01	8.64e-01
B-WICH-complex-positively-regulates-rRNA-expression	29	5.33e-01	6.85e-01	0.14600	-1.20e-01	0.082200	2.62e-01	4.43e-01
NR1H3-&-NR1H2-regulate-gene-expression-linked-to-cholesterol-transport-and-efflux	34	5.36e-01	6.88e-01	0.07180	1.41e-02	0.070400	8.87e-01	4.77e-01
Intra-Golgi-traffic	41	5.36e-01	6.88e-01	0.06380	6.18e-02	0.015700	4.94e-01	8.61e-01
Methylation	14	5.37e-01	6.89e-01	0.10500	-9.83e-02	-0.035700	5.24e-01	8.17e-01
Glyoxylate-metabolism-and-glycine-degradation	30	5.39e-01	6.90e-01	0.09660	1.54e-02	-0.095300	8.84e-01	3.66e-01
FGFR1-mutant-receptor-activation	27	5.40e-01	6.91e-01	0.06950	-5.20e-02	-0.046000	6.40e-01	6.79e-01
TGF-beta-receptor-signaling-in-EMT-(epithelial-to-mesenchymal-transition)	14	5.40e-01	6.91e-01	0.21800	1.68e-01	-0.140000	2.77e-01	3.66e-01
Transcriptional-Regulation-by-E2F6	33	5.41e-01	6.91e-01	0.13000	6.82e-02	-0.111000	4.98e-01	2.70e-01
Cell-death-signalling-via-NRAGE,-NRIF-and-NADE	73	5.41e-01	6.91e-01	0.04960	4.90e-02	0.007850	4.69e-01	9.08e-01
Metabolism-of-porphyrins	26	5.42e-01	6.91e-01	0.14700	-7.79e-02	0.125000	4.91e-01	2.70e-01
Glycogen-breakdown-(glycogenolysis)	14	5.42e-01	6.91e-01	0.13400	1.34e-01	-0.014000	3.86e-01	9.28e-01
Lysosome-Vesicle-Biogenesis	34	5.43e-01	6.91e-01	0.07470	-7.43e-02	-0.007790	4.53e-01	9.37e-01
AKT-phosphorylates-targets-in-the-cytosol	14	5.44e-01	6.91e-01	0.13500	-1.50e-02	0.134000	9.23e-01	3.85e-01
Recruitment-and-ATM-mediated-phosphorylation-of-repair-and-signaling-proteins-at-DNA-double-strand-breaks	41	5.44e-01	6.91e-01	0.08180	-1.28e-02	0.080800	8.88e-01	3.71e-01
Signaling-by-NTRK1-(TRKA)	112	5.45e-01	6.92e-01	0.06750	-3.24e-02	0.059200	5.53e-01	2.79e-01
FRS-mediated-FGFR2-signaling	20	5.45e-01	6.92e-01	0.16000	7.79e-02	-0.140000	5.46e-01	2.78e-01
Visual-phototransduction	85	5.47e-01	6.93e-01	0.04490	-8.36e-03	-0.044100	8.94e-01	4.81e-01
Conversion-from-APC/C:Cdc20-to-APC/C:Cdh1-in-late-anaphase	20	5.47e-01	6.93e-01	0.17800	1.41e-01	-0.110000	2.76e-01	3.95e-01
DNA-Double-Strand-Break-Response	42	5.48e-01	6.93e-01	0.09010	-2.57e-02	0.086400	7.73e-01	3.33e-01
RIP-mediated-NFkB-activation-via-ZBP1	17	5.48e-01	6.93e-01	0.18000	1.53e-01	-0.094400	2.75e-01	5.00e-01
ALK-mutants-bind-TKIs	11	5.49e-01	6.93e-01	0.11800	3.50e-02	0.113000	8.40e-01	5.17e-01
p75-NTR-receptor-mediated-signalling	92	5.49e-01	6.93e-01	0.05470	5.39e-02	-0.009180	3.71e-01	8.79e-01
NR1H2-and-NR1H3-mediated-signaling	44	5.52e-01	6.96e-01	0.12200	9.11e-02	-0.081800	2.96e-01	3.47e-01
Signaling-by-FLT3-ITD-and-TKD-mutants	16	5.58e-01	7.04e-01	0.17700	8.76e-02	-0.154000	5.44e-01	2.86e-01
Golgi-Cisternae-Pericentriolar-Stack-Reorganization	14	5.60e-01	7.05e-01	0.21400	1.43e-01	-0.160000	3.53e-01	3.01e-01
Termination-of-translesion-DNA-synthesis	30	5.63e-01	7.07e-01	0.06410	5.17e-02	0.037900	6.24e-01	7.19e-01
Glycogen-metabolism	25	5.64e-01	7.07e-01	0.13500	1.20e-01	-0.061100	2.98e-01	5.97e-01
Synthesis-of-substrates-in-N-glycan-biosythesis	57	5.64e-01	7.07e-01	0.06320	-4.93e-03	0.063000	9.49e-01	4.11e-01
Downstream-signaling-of-activated-FGFR3	23	5.64e-01	7.07e-01	0.07970	-2.37e-02	-0.076100	8.44e-01	5.27e-01
TGF-beta-receptor-signaling-activates-SMADs	31	5.65e-01	7.07e-01	0.13300	7.38e-02	-0.111000	4.77e-01	2.85e-01
Chaperonin-mediated-protein-folding	84	5.65e-01	7.07e-01	0.07360	3.34e-02	-0.065600	5.96e-01	2.99e-01
Cyclin-D-associated-events-in-G1	45	5.67e-01	7.09e-01	0.09850	8.86e-02	-0.043100	3.04e-01	6.16e-01
G1-Phase	45	5.67e-01	7.09e-01	0.09850	8.86e-02	-0.043100	3.04e-01	6.16e-01
Transport-of-Mature-mRNA-derived-from-an-Intron-Containing-Transcript	71	5.74e-01	7.17e-01	0.09390	-6.68e-02	0.065900	3.30e-01	3.37e-01
TRAF3-dependent-IRF-activation-pathway	13	5.76e-01	7.19e-01	0.10700	-1.04e-01	-0.025100	5.16e-01	8.75e-01
Fcgamma-receptor-(FCGR)-dependent-phagocytosis	95	5.77e-01	7.20e-01	0.07730	-6.20e-02	0.046200	2.96e-01	4.36e-01
Removal-of-the-Flap-Intermediate	14	5.80e-01	7.23e-01	0.13300	-2.21e-02	0.131000	8.86e-01	3.95e-01
Butyrate-Response-Factor-1-(BRF1)-binds-and-destabilizes-mRNA	16	5.82e-01	7.25e-01	0.16200	-1.45e-01	0.072400	3.14e-01	6.16e-01
Transport-of-Mature-Transcript-to-Cytoplasm	79	5.83e-01	7.25e-01	0.08680	-6.56e-02	0.056900	3.13e-01	3.82e-01
Interferon-alpha/beta-signaling	44	5.83e-01	7.25e-01	0.11700	-7.76e-02	0.087100	3.73e-01	3.18e-01
PI-3K-cascade:FGFR3	16	5.84e-01	7.26e-01	0.08460	-6.62e-02	-0.052600	6.47e-01	7.16e-01
RHOU-GTPase-cycle	40	5.85e-01	7.26e-01	0.08920	8.48e-02	-0.027500	3.53e-01	7.63e-01
Unfolded-Protein-Response-(UPR)	88	5.86e-01	7.26e-01	0.04020	-3.89e-02	-0.010200	5.28e-01	8.68e-01
HSP90-chaperone-cycle-for-steroid-hormone-receptors-(SHR)-in-the-presence-of-ligand	35	5.87e-01	7.27e-01	0.05840	2.84e-02	0.051100	7.71e-01	6.01e-01
Gastrin-CREB-signalling-pathway-via-PKC-and-MAPK	17	5.87e-01	7.27e-01	0.11400	1.13e-01	-0.012300	4.18e-01	9.30e-01
Endogenous-sterols	25	5.87e-01	7.27e-01	0.14000	1.19e-01	-0.074800	3.04e-01	5.18e-01
RUNX2-regulates-bone-development	31	5.91e-01	7.31e-01	0.13700	1.03e-01	-0.089500	3.20e-01	3.88e-01
Processive-synthesis-on-the-C-strand-of-the-telomere	19	5.93e-01	7.32e-01	0.07830	6.80e-02	0.039000	6.08e-01	7.69e-01
Defensins	18	5.95e-01	7.34e-01	0.08930	8.73e-02	0.018900	5.21e-01	8.89e-01
Pre-NOTCH-Processing-in-Golgi	18	5.96e-01	7.34e-01	0.08420	2.88e-02	0.079100	8.33e-01	5.61e-01
Amine-ligand-binding-receptors	30	5.98e-01	7.37e-01	0.06160	5.30e-02	0.031400	6.15e-01	7.66e-01
Tie2-Signaling	18	6.00e-01	7.38e-01	0.12900	-3.89e-02	0.123000	7.75e-01	3.67e-01
Glycogen-synthesis	14	6.00e-01	7.38e-01	0.20000	1.31e-01	-0.151000	3.94e-01	3.28e-01
Formation-of-TC-NER-Pre-Incision-Complex	52	6.02e-01	7.39e-01	0.07450	7.14e-02	-0.021300	3.73e-01	7.90e-01
Signaling-by-FGFR2-IIIa-TM	19	6.03e-01	7.40e-01	0.13700	1.26e-01	-0.054700	3.41e-01	6.80e-01
NOTCH1-Intracellular-Domain-Regulates-Transcription	46	6.03e-01	7.40e-01	0.09740	-4.82e-02	0.084600	5.72e-01	3.21e-01
G-beta:gamma-signalling-through-PI3Kgamma	23	6.03e-01	7.40e-01	0.08820	4.63e-06	0.088200	1.00e+00	4.64e-01
FGFR1-ligand-binding-and-activation	10	6.07e-01	7.44e-01	0.21400	-1.82e-01	0.114000	3.20e-01	5.34e-01
Downregulation-of-TGF-beta-receptor-signaling	25	6.09e-01	7.45e-01	0.14500	8.89e-02	-0.114000	4.41e-01	3.23e-01
Translesion-synthesis-by-Y-family-DNA-polymerases-bypasses-lesions-on-DNA-template	37	6.10e-01	7.46e-01	0.10600	9.30e-02	-0.051700	3.28e-01	5.86e-01
Vasopressin-regulates-renal-water-homeostasis-via-Aquaporins	40	6.10e-01	7.46e-01	0.07120	7.09e-02	-0.007140	4.38e-01	9.38e-01
Prostacyclin-signalling-through-prostacyclin-receptor	18	6.13e-01	7.48e-01	0.07870	3.59e-02	0.070000	7.92e-01	6.07e-01
Defective-TPR-may-confer-susceptibility-towards-thyroid-papillary-carcinoma-(TPC)	30	6.14e-01	7.48e-01	0.07180	7.15e-02	0.006210	4.98e-01	9.53e-01
Regulation-of-Glucokinase-by-Glucokinase-Regulatory-Protein	30	6.14e-01	7.48e-01	0.07180	7.15e-02	0.006210	4.98e-01	9.53e-01
Hyaluronan-uptake-and-degradation	12	6.15e-01	7.48e-01	0.10900	1.75e-02	0.107000	9.17e-01	5.20e-01
GABA-receptor-activation	53	6.19e-01	7.53e-01	0.09030	-4.66e-02	0.077300	5.57e-01	3.30e-01
SHC-mediated-cascade:FGFR4	17	6.20e-01	7.54e-01	0.09200	-1.20e-02	-0.091200	9.32e-01	5.15e-01
O-linked-glycosylation-of-mucins	52	6.21e-01	7.55e-01	0.05160	8.39e-03	0.050900	9.17e-01	5.25e-01
HuR-(ELAVL1)-binds-and-stabilizes-mRNA	10	6.24e-01	7.57e-01	0.23000	1.57e-01	-0.168000	3.91e-01	3.58e-01
RHOH-GTPase-cycle	37	6.24e-01	7.57e-01	0.09770	-4.15e-02	0.088400	6.62e-01	3.52e-01
TNFR1-induced-proapoptotic-signaling	13	6.31e-01	7.65e-01	0.17700	-1.53e-01	0.090700	3.41e-01	5.71e-01
Regulation-of-gene-expression-by-Hypoxia-inducible-Factor	11	6.33e-01	7.67e-01	0.18900	9.34e-02	-0.164000	5.92e-01	3.45e-01
Adenylate-cyclase-inhibitory-pathway	13	6.34e-01	7.67e-01	0.19500	-1.24e-01	0.150000	4.39e-01	3.49e-01
Transport-of-vitamins,-nucleosides,-and-related-molecules	37	6.35e-01	7.67e-01	0.05210	-2.70e-02	-0.044500	7.76e-01	6.39e-01
Caspase-activation-via-extrinsic-apoptotic-signalling-pathway	24	6.41e-01	7.74e-01	0.14400	-1.04e-01	0.100000	3.79e-01	3.95e-01
Interleukin-7-signaling	21	6.43e-01	7.75e-01	0.07090	-6.55e-02	-0.027100	6.03e-01	8.30e-01
ADP-signalling-through-P2Y-purinoceptor-12	20	6.43e-01	7.75e-01	0.10200	1.00e-01	-0.018500	4.38e-01	8.86e-01
Anchoring-of-the-basal-body-to-the-plasma-membrane	92	6.44e-01	7.76e-01	0.04610	4.56e-02	-0.006770	4.50e-01	9.11e-01
PECAM1-interactions	12	6.44e-01	7.76e-01	0.13500	-2.95e-02	0.132000	8.60e-01	4.28e-01
Response-of-Mtb-to-phagocytosis	21	6.46e-01	7.77e-01	0.12100	4.76e-02	-0.111000	7.06e-01	3.78e-01
Acetylcholine-binding-and-downstream-events	10	6.49e-01	7.80e-01	0.13000	-9.54e-03	0.130000	9.58e-01	4.76e-01
Postsynaptic-nicotinic-acetylcholine-receptors	10	6.49e-01	7.80e-01	0.13000	-9.54e-03	0.130000	9.58e-01	4.76e-01
ERK/MAPK-targets	22	6.50e-01	7.80e-01	0.07710	9.68e-03	0.076500	9.37e-01	5.35e-01
Xenobiotics	15	6.53e-01	7.82e-01	0.14100	-5.57e-02	0.130000	7.09e-01	3.83e-01
Acyl-chain-remodelling-of-PG	16	6.56e-01	7.85e-01	0.11000	1.08e-01	-0.018600	4.53e-01	8.97e-01
G2/M-DNA-damage-checkpoint	59	6.56e-01	7.85e-01	0.04560	4.50e-02	0.007410	5.50e-01	9.22e-01
Cytosolic-sulfonation-of-small-molecules	17	6.57e-01	7.86e-01	0.07500	3.42e-02	0.066800	8.07e-01	6.33e-01
Activation-of-kainate-receptors-upon-glutamate-binding	28	6.59e-01	7.87e-01	0.05600	3.95e-02	0.039700	7.17e-01	7.16e-01
Base-Excision-Repair,-AP-Site-Formation	18	6.59e-01	7.87e-01	0.09680	9.64e-02	-0.008700	4.79e-01	9.49e-01
WNT5A-dependent-internalization-of-FZD2,-FZD5-and-ROR2	13	6.59e-01	7.87e-01	0.18600	-1.17e-01	0.144000	4.64e-01	3.69e-01
Nitric-oxide-stimulates-guanylate-cyclase	21	6.61e-01	7.88e-01	0.07550	7.44e-02	0.012700	5.55e-01	9.20e-01
Transcriptional-regulation-of-white-adipocyte-differentiation	79	6.61e-01	7.88e-01	0.03680	-3.53e-02	-0.010500	5.87e-01	8.72e-01
Signalling-to-ERKs	33	6.62e-01	7.88e-01	0.09970	-4.52e-02	0.088800	6.53e-01	3.77e-01
DNA-Damage-Recognition-in-GG-NER	37	6.66e-01	7.92e-01	0.07740	7.46e-02	-0.020400	4.32e-01	8.30e-01
Biosynthesis-of-the-N-glycan-precursor-(dolichol-lipid-linked-oligosaccharide,-LLO)-and-transfer-to-a-nascent-protein	70	6.67e-01	7.93e-01	0.06170	-2.22e-02	0.057500	7.48e-01	4.05e-01
FRS-mediated-FGFR4-signaling	19	6.68e-01	7.93e-01	0.07950	-1.13e-02	-0.078700	9.32e-01	5.53e-01
Activation-of-PPARGC1A-(PGC-1alpha)-by-phosphorylation	10	6.69e-01	7.94e-01	0.15400	-4.77e-02	0.147000	7.94e-01	4.21e-01
Signaling-by-ERBB4	54	6.71e-01	7.96e-01	0.08110	4.14e-02	-0.069700	5.99e-01	3.75e-01
Regulation-of-PTEN-mRNA-translation	11	6.73e-01	7.97e-01	0.20100	-1.38e-01	0.146000	4.27e-01	4.03e-01
Meiotic-synapsis	31	6.74e-01	7.98e-01	0.06480	-3.58e-03	-0.064700	9.72e-01	5.33e-01
Beta-defensins	17	6.74e-01	7.98e-01	0.11200	1.08e-01	-0.028600	4.42e-01	8.38e-01
Synthesis-of-bile-acids-and-bile-salts-via-24-hydroxycholesterol	11	6.78e-01	8.00e-01	0.16300	6.96e-02	-0.147000	6.89e-01	3.97e-01
Synthesis-of-Prostaglandins-(PG)-and-Thromboxanes-(TX)	14	6.78e-01	8.00e-01	0.15100	1.33e-01	-0.071000	3.88e-01	6.45e-01
Transcriptional-Regulation-by-VENTX	37	6.79e-01	8.01e-01	0.07960	-2.54e-02	0.075500	7.89e-01	4.27e-01
mRNA-decay-by-3’-to-5’-exoribonuclease	15	6.79e-01	8.01e-01	0.15000	-7.50e-02	0.130000	6.15e-01	3.84e-01
Estrogen-dependent-nuclear-events-downstream-of-ESR-membrane-signaling	23	6.83e-01	8.04e-01	0.05920	4.50e-02	0.038400	7.09e-01	7.50e-01
Translocation-of-SLC2A4-(GLUT4)-to-the-plasma-membrane	50	6.83e-01	8.04e-01	0.04020	3.10e-02	0.025600	7.05e-01	7.54e-01
FOXO-mediated-transcription	61	6.86e-01	8.06e-01	0.06260	2.14e-02	-0.058900	7.72e-01	4.26e-01
ADP-signalling-through-P2Y-purinoceptor-1	24	6.87e-01	8.08e-01	0.05860	3.08e-02	0.049900	7.94e-01	6.72e-01
MicroRNA-(miRNA)-biogenesis	24	6.90e-01	8.09e-01	0.05930	2.73e-02	0.052700	8.17e-01	6.55e-01
Asparagine-N-linked-glycosylation	271	6.90e-01	8.09e-01	0.03830	-2.38e-02	0.030100	5.00e-01	3.94e-01
CDC6-association-with-the-ORC:origin-complex	11	6.91e-01	8.09e-01	0.19400	1.41e-01	-0.133000	4.18e-01	4.44e-01
Nucleotide-like-(purinergic)-receptors	15	6.91e-01	8.09e-01	0.07320	-4.05e-02	-0.061000	7.86e-01	6.82e-01
Removal-of-the-Flap-Intermediate-from-the-C-strand	17	6.91e-01	8.09e-01	0.10600	-2.55e-02	0.103000	8.56e-01	4.61e-01
Cleavage-of-the-damaged-pyrimidine	16	6.93e-01	8.09e-01	0.10200	1.01e-01	-0.016700	4.86e-01	9.08e-01
Depyrimidination	16	6.93e-01	8.09e-01	0.10200	1.01e-01	-0.016700	4.86e-01	9.08e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-pyrimidine	16	6.93e-01	8.09e-01	0.10200	1.01e-01	-0.016700	4.86e-01	9.08e-01
Metabolism-of-water-soluble-vitamins-and-cofactors	109	6.94e-01	8.09e-01	0.03680	-3.66e-02	0.003180	5.09e-01	9.54e-01
Depolymerisation-of-the-Nuclear-Lamina	15	6.94e-01	8.09e-01	0.11300	1.10e-01	-0.027600	4.62e-01	8.53e-01
Signaling-by-PDGFR-in-disease	19	6.94e-01	8.09e-01	0.11600	-1.07e-01	0.045900	4.20e-01	7.29e-01
Tryptophan-catabolism	12	6.96e-01	8.10e-01	0.14500	-1.34e-01	0.056800	4.22e-01	7.33e-01
Immune-System	1704	6.99e-01	8.12e-01	0.00711	3.34e-03	0.006270	8.17e-01	6.64e-01
CD28-co-stimulation	33	6.99e-01	8.12e-01	0.11000	-7.28e-02	0.081900	4.69e-01	4.15e-01
Regulation-of-gene-expression-in-beta-cells	18	6.99e-01	8.12e-01	0.13900	-7.83e-02	0.115000	5.65e-01	3.98e-01
IRE1alpha-activates-chaperones	49	6.99e-01	8.12e-01	0.08550	-4.94e-02	0.069800	5.49e-01	3.98e-01
Gap-junction-assembly	16	7.01e-01	8.13e-01	0.14900	-1.22e-01	0.085800	3.99e-01	5.52e-01
ZBP1(DAI)-mediated-induction-of-type-I-IFNs	20	7.01e-01	8.13e-01	0.10100	9.63e-02	-0.029000	4.56e-01	8.22e-01
Tristetraprolin-(TTP,-ZFP36)-binds-and-destabilizes-mRNA	16	7.03e-01	8.14e-01	0.06820	-5.15e-02	-0.044700	7.21e-01	7.57e-01
FGFR2-alternative-splicing	26	7.04e-01	8.14e-01	0.07970	1.45e-02	-0.078300	8.98e-01	4.89e-01
Other-interleukin-signaling	22	7.05e-01	8.15e-01	0.13100	-8.22e-02	0.101000	5.05e-01	4.10e-01
GABA-synthesis,-release,-reuptake-and-degradation	17	7.06e-01	8.16e-01	0.14200	8.09e-02	-0.117000	5.63e-01	4.04e-01
FOXO-mediated-transcription-of-oxidative-stress,-metabolic-and-neuronal-genes	29	7.07e-01	8.16e-01	0.08470	2.67e-02	-0.080300	8.04e-01	4.54e-01
Signaling-by-Nuclear-Receptors	226	7.09e-01	8.18e-01	0.04130	3.07e-02	-0.027600	4.26e-01	4.75e-01
FGFR3-ligand-binding-and-activation	11	7.12e-01	8.19e-01	0.15800	-1.40e-01	0.072600	4.21e-01	6.76e-01
FGFR3c-ligand-binding-and-activation	11	7.12e-01	8.19e-01	0.15800	-1.40e-01	0.072600	4.21e-01	6.76e-01
Platelet-Aggregation-(Plug-Formation)	37	7.12e-01	8.20e-01	0.04610	-1.99e-02	-0.041500	8.34e-01	6.62e-01
HSF1-dependent-transactivation	32	7.14e-01	8.21e-01	0.05520	-5.44e-02	-0.009300	5.94e-01	9.27e-01
FOXO-mediated-transcription-of-cell-death-genes	15	7.17e-01	8.24e-01	0.15100	-9.07e-02	0.121000	5.43e-01	4.17e-01
Signal-attenuation	10	7.19e-01	8.25e-01	0.14300	1.35e-01	-0.047900	4.59e-01	7.93e-01
Cleavage-of-the-damaged-purine	11	7.20e-01	8.25e-01	0.16400	-8.54e-02	0.140000	6.24e-01	4.20e-01
Depurination	11	7.20e-01	8.25e-01	0.16400	-8.54e-02	0.140000	6.24e-01	4.20e-01
Recognition-and-association-of-DNA-glycosylase-with-site-containing-an-affected-purine	11	7.20e-01	8.25e-01	0.16400	-8.54e-02	0.140000	6.24e-01	4.20e-01
Vitamin-D-(calciferol)-metabolism	11	7.21e-01	8.25e-01	0.16300	8.30e-02	-0.140000	6.33e-01	4.22e-01
MAPK3-(ERK1)-activation	10	7.22e-01	8.25e-01	0.19100	-1.34e-01	0.137000	4.64e-01	4.53e-01
Formation-of-Incision-Complex-in-GG-NER	41	7.23e-01	8.26e-01	0.06110	-1.12e-02	0.060000	9.01e-01	5.06e-01
ISG15-antiviral-mechanism	64	7.25e-01	8.27e-01	0.06640	3.34e-02	-0.057400	6.44e-01	4.27e-01
TNFs-bind-their-physiological-receptors	24	7.30e-01	8.33e-01	0.05270	4.02e-02	0.034100	7.33e-01	7.73e-01
Signaling-by-NTRK2-(TRKB)	25	7.32e-01	8.34e-01	0.05140	3.44e-02	0.038100	7.66e-01	7.42e-01
Platelet-sensitization-by-LDL	17	7.33e-01	8.35e-01	0.10400	9.86e-02	-0.031400	4.81e-01	8.22e-01
Oncogene-Induced-Senescence	31	7.36e-01	8.37e-01	0.05040	-1.48e-02	-0.048100	8.86e-01	6.43e-01
Activation-of-the-pre-replicative-complex	32	7.37e-01	8.38e-01	0.04850	4.56e-02	0.016500	6.55e-01	8.71e-01
Antiviral-mechanism-by-IFN-stimulated-genes	72	7.38e-01	8.39e-01	0.05720	2.52e-02	-0.051300	7.11e-01	4.51e-01
Rab-regulation-of-trafficking	119	7.39e-01	8.39e-01	0.04790	4.10e-02	-0.024800	4.40e-01	6.40e-01
RHO-GTPases-activate-KTN1	10	7.42e-01	8.41e-01	0.17700	1.40e-01	-0.107000	4.42e-01	5.57e-01
Nuclear-Events-(kinase-and-transcription-factor-activation)	61	7.43e-01	8.43e-01	0.06900	-5.70e-02	0.038900	4.41e-01	5.99e-01
Pexophagy	10	7.46e-01	8.44e-01	0.08040	6.87e-02	0.041800	7.07e-01	8.19e-01
Metabolism-of-amine-derived-hormones	16	7.46e-01	8.44e-01	0.10400	3.14e-02	-0.098800	8.28e-01	4.94e-01
Formation-of-Senescence-Associated-Heterochromatin-Foci-(SAHF)	11	7.47e-01	8.45e-01	0.15200	-7.56e-02	0.132000	6.64e-01	4.50e-01
Platelet-degranulation	118	7.52e-01	8.48e-01	0.05020	4.00e-02	-0.030400	4.53e-01	5.68e-01
NOTCH2-Activation-and-Transmission-of-Signal-to-the-Nucleus	21	7.53e-01	8.48e-01	0.10400	-9.27e-02	0.048000	4.62e-01	7.03e-01
SUMOylation-of-SUMOylation-proteins	33	7.53e-01	8.48e-01	0.06710	6.51e-02	-0.016200	5.18e-01	8.72e-01
RHOBTB3-ATPase-cycle	10	7.53e-01	8.48e-01	0.14600	1.32e-01	-0.062100	4.70e-01	7.34e-01
Inhibition-of-replication-initiation-of-damaged-DNA-by-RB1/E2F1	13	7.54e-01	8.48e-01	0.13100	1.17e-01	-0.058800	4.66e-01	7.14e-01
PI5P,-PP2A-and-IER3-Regulate-PI3K/AKT-Signaling	99	7.54e-01	8.48e-01	0.04320	-1.55e-02	0.040400	7.90e-01	4.87e-01
HATs-acetylate-histones	80	7.54e-01	8.48e-01	0.05790	-3.16e-02	0.048500	6.25e-01	4.53e-01
Glutathione-conjugation	29	7.55e-01	8.48e-01	0.10100	6.16e-02	-0.079800	5.66e-01	4.57e-01
Pyroptosis	21	7.55e-01	8.48e-01	0.09230	8.66e-02	-0.031900	4.92e-01	8.00e-01
Intrinsic-Pathway-for-Apoptosis	47	7.56e-01	8.48e-01	0.06150	5.78e-02	-0.021000	4.93e-01	8.03e-01
SUMOylation-of-ubiquitinylation-proteins	37	7.57e-01	8.49e-01	0.03980	2.83e-02	0.028000	7.66e-01	7.68e-01
Negative-regulation-of-the-PI3K/AKT-network	106	7.63e-01	8.56e-01	0.04370	-1.85e-02	0.039600	7.42e-01	4.81e-01
Activation-of-the-AP-1-family-of-transcription-factors	10	7.68e-01	8.60e-01	0.14100	6.07e-02	-0.128000	7.40e-01	4.85e-01
PIP3-activates-AKT-signaling	257	7.69e-01	8.60e-01	0.01980	-1.97e-02	0.000921	5.85e-01	9.80e-01
Signaling-by-WNT	257	7.69e-01	8.60e-01	0.02620	2.44e-02	-0.009650	5.00e-01	7.90e-01
Generic-Transcription-Pathway	905	7.69e-01	8.60e-01	0.00861	-2.89e-03	-0.008110	8.82e-01	6.78e-01
CaMK-IV-mediated-phosphorylation-of-CREB	10	7.71e-01	8.61e-01	0.13700	-5.57e-02	0.125000	7.61e-01	4.93e-01
DNA-Damage/Telomere-Stress-Induced-Senescence	28	7.74e-01	8.64e-01	0.05060	9.99e-03	0.049600	9.27e-01	6.49e-01
Activation-of-BH3-only-proteins	28	7.80e-01	8.70e-01	0.08250	3.61e-02	-0.074200	7.41e-01	4.97e-01
Acyl-chain-remodelling-of-PI	13	7.83e-01	8.72e-01	0.12900	6.57e-02	-0.111000	6.82e-01	4.87e-01
Activation-of-AMPK-downstream-of-NMDARs	10	7.83e-01	8.72e-01	0.07510	3.26e-02	0.067700	8.59e-01	7.11e-01
Oxidative-Stress-Induced-Senescence	62	7.86e-01	8.75e-01	0.05400	-4.89e-02	0.022900	5.06e-01	7.55e-01
Reversible-hydration-of-carbon-dioxide	12	7.88e-01	8.76e-01	0.10300	9.99e-02	-0.026700	5.49e-01	8.73e-01
CD209-(DC-SIGN)-signaling	19	7.90e-01	8.78e-01	0.11800	-8.12e-02	0.085400	5.40e-01	5.19e-01
Acyl-chain-remodelling-of-PC	23	7.93e-01	8.80e-01	0.07560	2.15e-02	-0.072500	8.58e-01	5.47e-01
CD28-dependent-PI3K/Akt-signaling	22	7.93e-01	8.80e-01	0.09830	-5.20e-02	0.083500	6.73e-01	4.98e-01
Diseases-of-programmed-cell-death	42	8.00e-01	8.87e-01	0.04360	-4.36e-02	0.000200	6.25e-01	9.98e-01
Phase-4—resting-membrane-potential	15	8.01e-01	8.87e-01	0.12800	-8.61e-02	0.095100	5.63e-01	5.24e-01
Phospholipase-C-mediated-cascade;-FGFR3	11	8.02e-01	8.87e-01	0.10100	2.24e-02	-0.098000	8.98e-01	5.74e-01
Regulation-of-IFNG-signaling	13	8.03e-01	8.87e-01	0.10500	3.71e-02	-0.097900	8.17e-01	5.41e-01
Uptake-and-function-of-anthrax-toxins	11	8.03e-01	8.87e-01	0.14400	8.72e-02	-0.115000	6.16e-01	5.11e-01
Killing-mechanisms	12	8.04e-01	8.87e-01	0.07810	-3.41e-03	-0.078000	9.84e-01	6.40e-01
WNT5:FZD7-mediated-leishmania-damping	12	8.04e-01	8.87e-01	0.07810	-3.41e-03	-0.078000	9.84e-01	6.40e-01
ERKs-are-inactivated	13	8.08e-01	8.91e-01	0.05920	4.76e-02	0.035200	7.66e-01	8.26e-01
Metabolism-of-steroid-hormones	30	8.10e-01	8.92e-01	0.03890	-2.27e-02	-0.031600	8.30e-01	7.64e-01
FCERI-mediated-MAPK-activation	40	8.10e-01	8.92e-01	0.07490	-5.86e-02	0.046600	5.21e-01	6.10e-01
SUMOylation-of-RNA-binding-proteins	45	8.13e-01	8.95e-01	0.06650	-5.53e-02	0.036800	5.21e-01	6.69e-01
Common-Pathway-of-Fibrin-Clot-Formation	20	8.15e-01	8.96e-01	0.10600	7.93e-02	-0.070900	5.39e-01	5.83e-01
Negative-regulation-of-FGFR3-signaling	26	8.16e-01	8.97e-01	0.07810	6.99e-02	-0.034700	5.37e-01	7.59e-01
CASP8-activity-is-inhibited	10	8.22e-01	9.01e-01	0.11400	-1.06e-01	0.041200	5.62e-01	8.22e-01
Dimerization-of-procaspase-8	10	8.22e-01	9.01e-01	0.11400	-1.06e-01	0.041200	5.62e-01	8.22e-01
Regulation-by-c-FLIP	10	8.22e-01	9.01e-01	0.11400	-1.06e-01	0.041200	5.62e-01	8.22e-01
Integrin-signaling	27	8.24e-01	9.02e-01	0.07550	3.42e-02	-0.067300	7.59e-01	5.45e-01
Negative-regulation-of-MET-activity	20	8.26e-01	9.02e-01	0.04990	-4.80e-02	-0.013600	7.10e-01	9.16e-01
Inhibition-of-DNA-recombination-at-telomere	21	8.28e-01	9.02e-01	0.07770	7.21e-02	-0.028900	5.67e-01	8.18e-01
Cobalamin-(Cbl,-vitamin-B12)-transport-and-metabolism	13	8.28e-01	9.02e-01	0.05850	-5.37e-02	-0.023300	7.38e-01	8.84e-01
Transport-of-Mature-mRNAs-Derived-from-Intronless-Transcripts	40	8.29e-01	9.02e-01	0.03300	1.40e-02	0.029900	8.78e-01	7.44e-01
Nucleobase-catabolism	33	8.31e-01	9.02e-01	0.07390	6.13e-02	-0.041300	5.42e-01	6.82e-01
Signaling-by-PDGFRA-extracellular-domain-mutants	12	8.31e-01	9.02e-01	0.05710	3.73e-02	0.043200	8.23e-01	7.95e-01
Signaling-by-PDGFRA-transmembrane,-juxtamembrane-and-kinase-domain-mutants	12	8.31e-01	9.02e-01	0.05710	3.73e-02	0.043200	8.23e-01	7.95e-01
Negative-regulation-of-FGFR4-signaling	27	8.32e-01	9.02e-01	0.08520	5.31e-02	-0.066700	6.33e-01	5.49e-01
COPII-mediated-vesicle-transport	68	8.32e-01	9.02e-01	0.05490	3.70e-02	-0.040600	5.97e-01	5.63e-01
mTORC1-mediated-signalling	24	8.32e-01	9.02e-01	0.07480	3.08e-02	-0.068100	7.94e-01	5.63e-01
Activation-of-GABAB-receptors	41	8.32e-01	9.02e-01	0.06340	-5.43e-02	0.032600	5.47e-01	7.18e-01
GABA-B-receptor-activation	41	8.32e-01	9.02e-01	0.06340	-5.43e-02	0.032600	5.47e-01	7.18e-01
FGFR3-mutant-receptor-activation	10	8.32e-01	9.02e-01	0.07430	-7.36e-02	-0.009890	6.87e-01	9.57e-01
Signaling-by-activated-point-mutants-of-FGFR3	10	8.32e-01	9.02e-01	0.07430	-7.36e-02	-0.009890	6.87e-01	9.57e-01
Transport-of-Mature-mRNA-Derived-from-an-Intronless-Transcript	39	8.37e-01	9.06e-01	0.03110	2.29e-02	0.020900	8.04e-01	8.21e-01
FGFR2c-ligand-binding-and-activation	10	8.37e-01	9.06e-01	0.13500	8.07e-02	-0.108000	6.59e-01	5.52e-01
XBP1(S)-activates-chaperone-genes	47	8.38e-01	9.07e-01	0.05260	-2.19e-02	0.047800	7.95e-01	5.71e-01
Signaling-by-FGFR3	37	8.40e-01	9.08e-01	0.05180	1.49e-02	-0.049600	8.75e-01	6.01e-01
TP53-Regulates-Transcription-of-Cell-Death-Genes	37	8.40e-01	9.08e-01	0.03730	5.50e-03	0.036900	9.54e-01	6.98e-01
MAPK-targets/-Nuclear-events-mediated-by-MAP-kinases	31	8.47e-01	9.14e-01	0.04490	4.49e-02	-0.001870	6.65e-01	9.86e-01
Metabolism-of-fat-soluble-vitamins	41	8.51e-01	9.17e-01	0.03110	-2.92e-02	-0.010800	7.46e-01	9.05e-01
RAB-GEFs-exchange-GTP-for-GDP-on-RABs	88	8.54e-01	9.21e-01	0.03720	-3.34e-02	0.016400	5.88e-01	7.91e-01
MET-activates-RAS-signaling	11	8.58e-01	9.24e-01	0.12400	9.28e-02	-0.082100	5.94e-01	6.37e-01
LDL-clearance	19	8.59e-01	9.24e-01	0.08830	7.30e-02	-0.049800	5.82e-01	7.07e-01
Defects-in-cobalamin-(B12)-metabolism	12	8.61e-01	9.24e-01	0.05340	-4.75e-02	-0.024400	7.76e-01	8.84e-01
Signaling-by-Non-Receptor-Tyrosine-Kinases	52	8.61e-01	9.24e-01	0.03460	3.44e-02	-0.003650	6.68e-01	9.64e-01
Signaling-by-PTK6	52	8.61e-01	9.24e-01	0.03460	3.44e-02	-0.003650	6.68e-01	9.64e-01
TP53-regulates-transcription-of-several-additional-cell-death-genes-whose-specific-roles-in-p53-dependent-apoptosis-remain-uncertain	13	8.64e-01	9.27e-01	0.11200	7.68e-02	-0.081700	6.32e-01	6.10e-01
Signal-amplification	31	8.65e-01	9.27e-01	0.03870	3.19e-03	0.038500	9.75e-01	7.10e-01
Transport-of-the-SLBP-Dependant-Mature-mRNA	34	8.65e-01	9.27e-01	0.03700	2.77e-03	0.036900	9.78e-01	7.09e-01
Erythropoietin-activates-RAS	14	8.66e-01	9.28e-01	0.08090	2.80e-02	-0.075900	8.56e-01	6.23e-01
Phospholipase-C-mediated-cascade:-FGFR1	11	8.70e-01	9.30e-01	0.07730	-7.60e-02	0.014300	6.63e-01	9.34e-01
Competing-endogenous-RNAs-(ceRNAs)-regulate-PTEN-translation	10	8.70e-01	9.30e-01	0.12500	-8.80e-02	0.088800	6.30e-01	6.27e-01
AKT-phosphorylates-targets-in-the-nucleus	10	8.71e-01	9.30e-01	0.10300	4.55e-02	-0.092900	8.03e-01	6.11e-01
Post-translational-protein-modification	1263	8.72e-01	9.31e-01	0.00670	6.68e-03	-0.000508	6.88e-01	9.76e-01
P2Y-receptors	11	8.72e-01	9.31e-01	0.05190	-2.89e-02	-0.043100	8.68e-01	8.04e-01
Cytosolic-sensors-of-pathogen-associated-DNA	58	8.76e-01	9.33e-01	0.02320	9.40e-03	0.021300	9.01e-01	7.79e-01
CREB1-phosphorylation-through-the-activation-of-Adenylate-Cyclase	11	8.76e-01	9.33e-01	0.10800	-5.96e-02	0.089600	7.32e-01	6.07e-01
Phase-I—Functionalization-of-compounds	83	8.77e-01	9.33e-01	0.02170	3.11e-03	0.021500	9.61e-01	7.35e-01
Activation-of-G-protein-gated-Potassium-channels	28	8.80e-01	9.35e-01	0.03100	-2.19e-02	-0.022000	8.41e-01	8.41e-01
G-protein-gated-Potassium-channels	28	8.80e-01	9.35e-01	0.03100	-2.19e-02	-0.022000	8.41e-01	8.41e-01
Inhibition–of-voltage-gated-Ca2+-channels-via-Gbeta/gamma-subunits	28	8.80e-01	9.35e-01	0.03100	-2.19e-02	-0.022000	8.41e-01	8.41e-01
Transport-of-the-SLBP-independent-Mature-mRNA	33	8.82e-01	9.36e-01	0.02960	1.30e-02	0.026600	8.97e-01	7.92e-01
Cooperation-of-PDCL-(PhLP1)-and-TRiC/CCT-in-G-protein-beta-folding	36	8.82e-01	9.36e-01	0.02780	-2.39e-02	-0.014200	8.04e-01	8.83e-01
Intracellular-signaling-by-second-messengers	295	8.83e-01	9.36e-01	0.01820	-8.14e-03	0.016300	8.10e-01	6.29e-01
Activation-of-BAD-and-translocation-to-mitochondria	14	8.84e-01	9.37e-01	0.05980	5.70e-03	-0.059500	9.71e-01	7.00e-01
PKMTs-methylate-histone-lysines	39	8.86e-01	9.38e-01	0.03870	7.72e-03	-0.038000	9.33e-01	6.82e-01
Cytochrome-P450—arranged-by-substrate-type	48	8.90e-01	9.41e-01	0.05230	-3.68e-02	0.037200	6.59e-01	6.55e-01
Frs2-mediated-activation	12	8.92e-01	9.42e-01	0.07790	-7.32e-02	0.026800	6.61e-01	8.72e-01
Retrograde-neurotrophin-signalling	14	8.92e-01	9.42e-01	0.05110	5.10e-02	0.003950	7.41e-01	9.80e-01
Signaling-by-NODAL	17	8.97e-01	9.47e-01	0.06470	2.32e-02	-0.060300	8.68e-01	6.67e-01
SARS-CoV-2-Infection	68	8.97e-01	9.47e-01	0.03790	-1.96e-02	0.032400	7.80e-01	6.44e-01
Negative-regulation-of-FGFR1-signaling	26	8.98e-01	9.47e-01	0.03100	2.83e-02	0.012800	8.03e-01	9.10e-01
Cell-recruitment-(pro-inflammatory-response)	24	9.00e-01	9.47e-01	0.06930	-4.45e-02	0.053000	7.06e-01	6.53e-01
Purinergic-signaling-in-leishmaniasis-infection	24	9.00e-01	9.47e-01	0.06930	-4.45e-02	0.053000	7.06e-01	6.53e-01
Signaling-by-KIT-in-disease	20	9.02e-01	9.48e-01	0.03320	2.07e-02	0.025900	8.73e-01	8.41e-01
Signaling-by-phosphorylated-juxtamembrane,-extracellular-and-kinase-domain-KIT-mutants	20	9.02e-01	9.48e-01	0.03320	2.07e-02	0.025900	8.73e-01	8.41e-01
Processing-of-DNA-double-strand-break-ends	61	9.03e-01	9.48e-01	0.02760	2.73e-02	-0.004450	7.13e-01	9.52e-01
Purine-salvage	13	9.03e-01	9.48e-01	0.05140	-1.95e-03	-0.051400	9.90e-01	7.48e-01
G1/S-Specific-Transcription	28	9.04e-01	9.49e-01	0.04000	-3.96e-02	0.006080	7.17e-01	9.56e-01
Formation-of-Fibrin-Clot-(Clotting-Cascade)	37	9.06e-01	9.49e-01	0.04040	1.30e-02	-0.038200	8.91e-01	6.87e-01
Ethanol-oxidation	10	9.08e-01	9.50e-01	0.05050	4.86e-02	0.013400	7.90e-01	9.41e-01
Inwardly-rectifying-K+-channels	34	9.08e-01	9.50e-01	0.05350	-4.34e-02	0.031300	6.61e-01	7.52e-01
TFAP2-(AP-2)-family-regulates-transcription-of-growth-factors-and-their-receptors	11	9.09e-01	9.50e-01	0.09790	-6.46e-02	0.073600	7.10e-01	6.73e-01
Retinoid-metabolism-and-transport	38	9.09e-01	9.50e-01	0.02300	-1.57e-02	-0.016800	8.67e-01	8.58e-01
Maturation-of-nucleoprotein	11	9.10e-01	9.50e-01	0.09080	5.00e-02	-0.075700	7.74e-01	6.64e-01
Purine-catabolism	16	9.11e-01	9.51e-01	0.06630	-5.99e-02	0.028600	6.78e-01	8.43e-01
Biological-oxidations	168	9.12e-01	9.51e-01	0.01570	-2.33e-03	0.015500	9.58e-01	7.29e-01
Degradation-of-cysteine-and-homocysteine	14	9.13e-01	9.51e-01	0.07090	-6.37e-02	0.031000	6.80e-01	8.41e-01
Gap-junction-trafficking	24	9.15e-01	9.52e-01	0.03290	-3.25e-02	-0.005360	7.83e-01	9.64e-01
Synthesis-of-bile-acids-and-bile-salts-via-27-hydroxycholesterol	12	9.16e-01	9.52e-01	0.04130	-1.75e-02	-0.037500	9.16e-01	8.22e-01
NOTCH4-Activation-and-Transmission-of-Signal-to-the-Nucleus	10	9.16e-01	9.52e-01	0.09510	-7.65e-02	0.056500	6.75e-01	7.57e-01
Transcription-of-E2F-targets-under-negative-control-by-DREAM-complex	19	9.16e-01	9.52e-01	0.03400	1.10e-02	0.032100	9.34e-01	8.08e-01
SARS-CoV-1-Infection	47	9.18e-01	9.53e-01	0.02050	9.18e-03	0.018300	9.13e-01	8.28e-01
GAB1-signalosome	16	9.18e-01	9.53e-01	0.05200	-5.07e-02	0.011600	7.26e-01	9.36e-01
Response-to-elevated-platelet-cytosolic-Ca2+	123	9.20e-01	9.54e-01	0.02660	1.60e-02	-0.021200	7.59e-01	6.85e-01
Telomere-Extension-By-Telomerase	22	9.23e-01	9.56e-01	0.04550	-4.37e-02	0.013000	7.23e-01	9.16e-01
SHC-mediated-cascade:FGFR1	16	9.26e-01	9.57e-01	0.06710	-5.64e-02	0.036400	6.96e-01	8.01e-01
SUMOylation-of-DNA-damage-response-and-repair-proteins	74	9.27e-01	9.57e-01	0.01530	1.36e-02	0.007090	8.40e-01	9.16e-01
Eicosanoid-ligand-binding-receptors	14	9.27e-01	9.57e-01	0.03470	-2.97e-02	-0.017900	8.48e-01	9.08e-01
Meiosis	56	9.27e-01	9.57e-01	0.03840	2.94e-02	-0.024600	7.03e-01	7.50e-01
Defects-of-contact-activation-system-(CAS)-and-kallikrein/kinin-system-(KKS)	16	9.27e-01	9.57e-01	0.03320	1.40e-02	0.030100	9.23e-01	8.35e-01
Diseases-of-hemostasis	16	9.27e-01	9.57e-01	0.03320	1.40e-02	0.030100	9.23e-01	8.35e-01
activated-TAK1-mediates-p38-MAPK-activation	18	9.29e-01	9.58e-01	0.03330	-7.93e-03	-0.032300	9.54e-01	8.12e-01
Gap-junction-trafficking-and-regulation	26	9.30e-01	9.58e-01	0.02660	8.31e-03	0.025300	9.42e-01	8.23e-01
Cellular-response-to-heat-stress	92	9.31e-01	9.58e-01	0.02250	-2.10e-02	0.008080	7.27e-01	8.93e-01
Postmitotic-nuclear-pore-complex-(NPC)-reformation	27	9.32e-01	9.58e-01	0.04350	1.77e-02	-0.039700	8.73e-01	7.21e-01
Signaling-by-Retinoic-Acid	39	9.32e-01	9.58e-01	0.04470	-3.34e-02	0.029700	7.18e-01	7.48e-01
RNA-Polymerase-II-Pre-transcription-Events	75	9.33e-01	9.58e-01	0.03230	-2.22e-02	0.023400	7.39e-01	7.26e-01
FRS-mediated-FGFR1-signaling	18	9.33e-01	9.58e-01	0.06180	-5.07e-02	0.035400	7.10e-01	7.95e-01
TP53-regulates-transcription-of-additional-cell-cycle-genes-whose-exact-role-in-the-p53-pathway-remain-uncertain	19	9.33e-01	9.58e-01	0.06210	4.88e-02	-0.038400	7.13e-01	7.72e-01
Ephrin-signaling	17	9.34e-01	9.58e-01	0.02960	2.47e-02	0.016400	8.60e-01	9.07e-01
EGR2-and-SOX10-mediated-initiation-of-Schwann-cell-myelination	27	9.34e-01	9.58e-01	0.04460	-3.98e-02	0.020200	7.20e-01	8.56e-01
Antigen-Presentation:-Folding,-assembly-and-peptide-loading-of-class-I-MHC	17	9.37e-01	9.59e-01	0.06290	5.05e-02	-0.037500	7.18e-01	7.89e-01
TCF-dependent-signaling-in-response-to-WNT	164	9.38e-01	9.60e-01	0.01880	1.61e-02	-0.009710	7.21e-01	8.30e-01
Digestion	11	9.41e-01	9.62e-01	0.05690	5.43e-02	-0.016900	7.55e-01	9.23e-01
Intrinsic-Pathway-of-Fibrin-Clot-Formation	22	9.45e-01	9.66e-01	0.02360	-1.94e-02	-0.013400	8.75e-01	9.13e-01
SHC-mediated-cascade:FGFR3	16	9.49e-01	9.68e-01	0.04240	1.12e-02	-0.040900	9.38e-01	7.77e-01
Signaling-by-ALK-fusions-and-activated-point-mutants	52	9.50e-01	9.68e-01	0.03050	1.66e-02	-0.025600	8.36e-01	7.49e-01
Signaling-by-ALK-in-cancer	52	9.50e-01	9.68e-01	0.03050	1.66e-02	-0.025600	8.36e-01	7.49e-01
tRNA-processing-in-the-nucleus	55	9.53e-01	9.68e-01	0.02230	6.55e-03	-0.021400	9.33e-01	7.84e-01
Cellular-Senescence	124	9.54e-01	9.68e-01	0.00952	-3.77e-03	-0.008740	9.42e-01	8.66e-01
Regulation-of-localization-of-FOXO-transcription-factors	11	9.54e-01	9.68e-01	0.06520	3.75e-02	-0.053400	8.30e-01	7.59e-01
HIV-Transcription-Initiation	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-HIV-Promoter-Escape	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Promoter-Escape	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Transcription-Initiation	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Transcription-Initiation-And-Promoter-Clearance	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RNA-Polymerase-II-Transcription-Pre-Initiation-And-Promoter-Opening	45	9.55e-01	9.68e-01	0.02650	-2.45e-02	0.010200	7.76e-01	9.06e-01
RHO-GTPases-activate-IQGAPs	11	9.60e-01	9.72e-01	0.05560	2.66e-02	-0.048800	8.78e-01	7.79e-01
STAT5-activation-downstream-of-FLT3-ITD-mutants	10	9.61e-01	9.72e-01	0.06640	4.93e-02	-0.044600	7.87e-01	8.07e-01
Insertion-of-tail-anchored-proteins-into-the-endoplasmic-reticulum-membrane	20	9.61e-01	9.72e-01	0.02890	-3.45e-03	0.028700	9.79e-01	8.24e-01
Sulfur-amino-acid-metabolism	27	9.62e-01	9.72e-01	0.03070	1.10e-02	-0.028700	9.21e-01	7.96e-01
FRS-mediated-FGFR3-signaling	18	9.62e-01	9.72e-01	0.03460	9.46e-03	-0.033300	9.45e-01	8.07e-01
Interferon-Signaling	152	9.66e-01	9.75e-01	0.00850	7.68e-04	0.008470	9.87e-01	8.57e-01
Processing-of-SMDT1	15	9.67e-01	9.75e-01	0.05040	-3.69e-02	0.034300	8.05e-01	8.18e-01
Mitochondrial-biogenesis	73	9.67e-01	9.75e-01	0.01310	5.41e-04	-0.013100	9.94e-01	8.47e-01
Signaling-by-MET	66	9.70e-01	9.77e-01	0.01760	1.63e-02	-0.006530	8.19e-01	9.27e-01
Heme-degradation	14	9.71e-01	9.77e-01	0.04530	3.76e-02	-0.025200	8.07e-01	8.70e-01
Transcription-of-E2F-targets-under-negative-control-by-p107-(RBL1)-and-p130-(RBL2)-in-complex-with-HDAC1	16	9.72e-01	9.78e-01	0.03250	-1.02e-02	0.030800	9.43e-01	8.31e-01
Glycogen-storage-diseases	13	9.73e-01	9.79e-01	0.04790	3.57e-02	-0.032000	8.24e-01	8.42e-01
Constitutive-Signaling-by-AKT1-E17K-in-Cancer	26	9.75e-01	9.80e-01	0.03010	1.62e-02	-0.025400	8.87e-01	8.23e-01
Surfactant-metabolism	23	9.82e-01	9.86e-01	0.02910	1.81e-02	-0.022800	8.81e-01	8.50e-01
Phase-II—Conjugation-of-compounds	80	9.89e-01	9.92e-01	0.01220	7.40e-03	-0.009660	9.09e-01	8.81e-01
ESR-mediated-signaling	157	9.90e-01	9.92e-01	0.00839	6.62e-03	-0.005150	8.86e-01	9.11e-01
tRNA-processing	113	9.91e-01	9.93e-01	0.00572	5.68e-03	-0.000713	9.17e-01	9.90e-01
Regulation-of-HSF1-mediated-heat-shock-response	74	9.95e-01	9.96e-01	0.00905	-5.97e-03	0.006800	9.29e-01	9.19e-01
Transcription-of-the-HIV-genome	64	9.96e-01	9.96e-01	0.00803	6.68e-03	-0.004450	9.26e-01	9.51e-01
Suppression-of-phagosomal-maturation	12	9.98e-01	9.98e-01	0.01130	-5.90e-03	0.009610	9.72e-01	9.54e-01

---

Detailed Gene set reports

Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency

Response-of-EIF2AK4-(GCN2)-to-amino-acid-deficiency

metric	value
setSize	85
pMANOVA	1.11e-34
p.adjustMANOVA	1.65e-31
s.dist	1.01
s.diab	0.665
s.PMX	-0.757
p.diab	2.47e-26
p.PMX	1.35e-33

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Asns	14974.0	-13140.0
Atf2	-6723.0	3300.0
Atf3	5940.0	-10511.0
Atf4	10850.0	-13249.0
Cebpb	15167.0	-15133.0
Cebpg	-7894.0	-8449.0
Ddit3	13910.0	-13026.0
Eif2ak4	12662.0	-12468.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Flt3l	-10231.0	11283.0
Gcn1l1	-8991.0	12087.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Impact	7475.0	-12025.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Trib3	13141.0	-7115.0
Uba52	4596.0	-6796.0

---

---

Viral-mRNA-Translation

Viral-mRNA-Translation

metric	value
setSize	73
pMANOVA	2.05e-33
p.adjustMANOVA	1.52e-30
s.dist	1.07
s.diab	0.701
s.PMX	-0.802
p.diab	3.15e-25
p.PMX	1.64e-32

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Dnajc3	-9188.0	-13392.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Grsf1	9214.0	-9055.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Peptide-chain-elongation

Peptide-chain-elongation

metric	value
setSize	73
pMANOVA	1.36e-32
p.adjustMANOVA	6.71e-30
s.dist	1.05
s.diab	0.699
s.PMX	-0.789
p.diab	4.63e-25
p.PMX	1.69e-31

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eef1a1	6403.0	-13665.0
Eef2	-8913.0	4813.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Formation-of-a-pool-of-free-40S-subunits

Formation-of-a-pool-of-free-40S-subunits

metric	value
setSize	85
pMANOVA	2.2e-32
p.adjustMANOVA	8.16e-30
s.dist	0.976
s.diab	0.653
s.PMX	-0.725
p.diab	2e-25
p.PMX	5.44e-31

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit

GTP-hydrolysis-and-joining-of-the-60S-ribosomal-subunit

metric	value
setSize	96
pMANOVA	2.23e-31
p.adjustMANOVA	6.62e-29
s.dist	0.895
s.diab	0.578
s.PMX	-0.684
p.diab	1.14e-22
p.PMX	3.98e-31

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Eukaryotic-Translation-Elongation

Eukaryotic-Translation-Elongation

metric	value
setSize	77
pMANOVA	2.8e-31
p.adjustMANOVA	6.91e-29
s.dist	1
s.diab	0.665
s.PMX	-0.753
p.diab	5.05e-24
p.PMX	2.61e-30

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eef1a1	6403.0	-13665.0
Eef1a2	10648.0	-10014.0
Eef1b2	14272.0	-14363.0
Eef1d	-8373.0	5588.0
Eef1g	-8453.0	9394.0
Eef2	-8913.0	4813.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

L13a-mediated-translational-silencing-of-Ceruloplasmin-expression

L13a-mediated-translational-silencing-of-Ceruloplasmin-expression

metric	value
setSize	95
pMANOVA	4.56e-30
p.adjustMANOVA	9.66e-28
s.dist	0.883
s.diab	0.574
s.PMX	-0.671
p.diab	3.79e-22
p.PMX	1.08e-29

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Cellular-response-to-starvation

Cellular-response-to-starvation

metric	value
setSize	138
pMANOVA	2.09e-29
p.adjustMANOVA	3.87e-27
s.dist	0.734
s.diab	0.517
s.PMX	-0.521
p.diab	8.43e-26
p.PMX	3.42e-26

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Atp6v0e	14931	-14952
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Sesn1	14846	-14730
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843

Click HERE to show all gene set members

All member genes

	diab	PMX
Asns	14974.0	-13140.0
Atf2	-6723.0	3300.0
Atf3	5940.0	-10511.0
Atf4	10850.0	-13249.0
Atp6v0b	4840.0	2125.0
Atp6v0c	3151.0	-10611.0
Atp6v0d1	203.0	1912.0
Atp6v0d2	15150.0	-3904.0
Atp6v0e	14931.0	-14952.0
Atp6v0e2	7872.0	6422.0
Atp6v1a	10227.0	-7433.0
Atp6v1b1	13172.0	12006.0
Atp6v1b2	-7304.0	5553.0
Atp6v1c1	12161.0	-10561.0
Atp6v1c2	14305.0	9508.0
Atp6v1d	12172.0	-14697.0
Atp6v1e1	13351.0	-11187.0
Atp6v1f	14121.0	-13473.0
Atp6v1g1	15089.0	-12782.0
Atp6v1g2	-3055.0	4701.0
Atp6v1g3	14162.0	-9021.0
Atp6v1h	9566.0	-8530.0
BC048403	8126.0	-4500.0
Cebpb	15167.0	-15133.0
Cebpg	-7894.0	-8449.0
Ddit3	13910.0	-13026.0
Depdc5	10603.0	-12516.0
Eif2ak4	12662.0	-12468.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Flcn	8427.0	2620.0
Flt3l	-10231.0	11283.0
Fnip1	5376.0	-14121.0
Fnip2	6241.0	-11575.0
Gatsl2	10871.0	-9194.0
Gatsl3	-1475.0	8414.0
Gcn1l1	-8991.0	12087.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Impact	7475.0	-12025.0
Itfg2	10888.0	-7999.0
Kptn	-3141.0	-2510.0
Lamtor1	8753.0	5215.0
Lamtor2	-7753.0	1820.0
Lamtor3	11338.0	-7218.0
Lamtor4	5699.0	-11078.0
Lamtor5	13418.0	-13042.0
Mios	6357.0	-10601.0
Mlst8	-8191.0	9545.0
Mtor	-12191.0	-146.0
Nprl2	-3481.0	7578.0
Nprl3	7260.0	4129.0
Rheb	-8480.0	2846.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rptor	4891.0	6876.0
Rraga	-11375.0	9072.0
Rragb	10214.0	2103.0
Rragc	10681.0	-445.0
Rragd	15304.0	-13993.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Sesn1	14846.0	-14730.0
Sesn2	2837.0	-13400.0
Sh3bp4	14556.0	-12878.0
Slc38a9	-7282.0	6109.0
Szt2	-5351.0	10104.0
Tcirg1	-10070.0	11128.0
Trib3	13141.0	-7115.0
Uba52	4596.0	-6796.0
Wdr24	-11111.0	12295.0
Wdr59	-5055.0	-6197.0

---

---

Cap-dependent-Translation-Initiation

Cap-dependent-Translation-Initiation

metric	value
setSize	103
pMANOVA	4.08e-29
p.adjustMANOVA	5.92e-27
s.dist	0.837
s.diab	0.551
s.PMX	-0.63
p.diab	4.15e-22
p.PMX	1.83e-28

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Eif4ebp1	15028	-14599
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2b1	11279.0	-2807.0
Eif2b2	-5526.0	8016.0
Eif2b3	-275.0	-7159.0
Eif2b4	-5228.0	6620.0
Eif2b5	9058.0	8598.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4ebp1	15028.0	-14599.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Eukaryotic-Translation-Initiation

Eukaryotic-Translation-Initiation

metric	value
setSize	103
pMANOVA	4.08e-29
p.adjustMANOVA	5.92e-27
s.dist	0.837
s.diab	0.551
s.PMX	-0.63
p.diab	4.15e-22
p.PMX	1.83e-28

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Eif4ebp1	15028	-14599
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602.0
Eif2b1	11279.0	-2807.0
Eif2b2	-5526.0	8016.0
Eif2b3	-275.0	-7159.0
Eif2b4	-5228.0	6620.0
Eif2b5	9058.0	8598.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4ebp1	15028.0	-14599.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0

---

---

Eukaryotic-Translation-Termination

Eukaryotic-Translation-Termination

metric	value
setSize	77
pMANOVA	4.39e-29
p.adjustMANOVA	5.92e-27
s.dist	0.97
s.diab	0.646
s.PMX	-0.723
p.diab	9.58e-23
p.PMX	4.67e-28

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Apeh	-11381.0	10100.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
N6amt1	-5072.0	10569.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Trmt112	-11645.0	12227.0
Uba52	4596.0	-6796.0

---

---

Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)

Nonsense-Mediated-Decay-(NMD)-independent-of-the-Exon-Junction-Complex-(EJC)

metric	value
setSize	79
pMANOVA	3.34e-27
p.adjustMANOVA	4.12e-25
s.dist	0.925
s.diab	0.617
s.PMX	-0.69
p.diab	2.42e-21
p.PMX	2.63e-26

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Uba52	4596.0	-6796.0
Upf1	-11946.0	12557.0

---

---

Selenocysteine-synthesis

Selenocysteine-synthesis

metric	value
setSize	76
pMANOVA	9.92e-27
p.adjustMANOVA	1.13e-24
s.dist	0.935
s.diab	0.624
s.PMX	-0.696
p.diab	4.92e-21
p.PMX	7.72e-26

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Eefsec	-7997.0	11830.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Pstk	-9537.0	9420.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Secisbp2	-9337.0	10086.0
Sephs2	-10506.0	11018.0
Sepsecs	-12324.0	11433.0
Uba52	4596.0	-6796.0

---

---

SRP-dependent-cotranslational-protein-targeting-to-membrane

SRP-dependent-cotranslational-protein-targeting-to-membrane

metric	value
setSize	96
pMANOVA	6.92e-26
p.adjustMANOVA	7.33e-24
s.dist	0.786
s.diab	0.465
s.PMX	-0.633
p.diab	3.24e-15
p.PMX	6.67e-27

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Ddost	-11311.0	11142.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpn1	-12234.0	10781.0
Rpn2	-8531.0	4240.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sec11a	-10050.0	-13192.0
Sec11c	6317.0	-11728.0
Sec61a1	-10632.0	9529.0
Sec61a2	2273.0	-12284.0
Sec61b	-6804.0	8046.0
Sec61g	2842.0	-5782.0
Spcs1	-9784.0	-9337.0
Spcs2	-11309.0	6712.0
Spcs3	6719.0	-10661.0
Srp14	10201.0	-11271.0
Srp19	-8639.0	-9543.0
Srp54a	-4764.0	766.0
Srp68	4472.0	-4510.0
Srp72	8797.0	-11367.0
Srp9	-1833.0	-7812.0
Srpr	10750.0	-13353.0
Srprb	3421.0	2100.0
Ssr1	-11725.0	10337.0
Ssr2	-8791.0	-2977.0
Ssr3	-933.0	-13076.0
Ssr4	11159.0	-13592.0
Tram1	-12409.0	9369.0
Uba52	4596.0	-6796.0

---

---

Influenza-Viral-RNA-Transcription-and-Replication

Influenza-Viral-RNA-Transcription-and-Replication

metric	value
setSize	118
pMANOVA	8.5e-24
p.adjustMANOVA	8.4e-22
s.dist	0.711
s.diab	0.489
s.PMX	-0.516
p.diab	4.21e-20
p.PMX	3.11e-22

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Dnajc3	-9188.0	-13392.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Grsf1	9214.0	-9055.0
Gtf2f1	10842.0	-11838.0
Gtf2f2	11210.0	-13043.0
Hsp90aa1	-12505.0	4614.0
Ipo5	11718.0	-12610.0
Ndc1	13238.0	-12109.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Parp1	-4209.0	11584.0
Polr2a	5917.0	6827.0
Polr2b	-9995.0	7496.0
Polr2c	-2600.0	9289.0
Polr2d	-4100.0	39.0
Polr2e	11726.0	-9159.0
Polr2f	11374.0	-6543.0
Polr2g	11118.0	-13257.0
Polr2h	224.0	-7426.0
Polr2i	13554.0	-12640.0
Polr2j	9902.0	-6099.0
Polr2k	7520.0	-11503.0
Polr2l	6213.0	4463.0
Pom121	9659.0	-12785.0
Rae1	-2818.0	7959.0
Ranbp2	-1884.0	-9227.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Tpr	-7568.0	-3358.0
Uba52	4596.0	-6796.0

---

---

Regulation-of-expression-of-SLITs-and-ROBOs

Regulation-of-expression-of-SLITs-and-ROBOs

metric	value
setSize	149
pMANOVA	4.28e-23
p.adjustMANOVA	3.97e-21
s.dist	0.608
s.diab	0.379
s.PMX	-0.475
p.diab	1.18e-15
p.PMX	1.16e-23

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Psmd8	14709	-14720
Psmd9	14751	-14675

Click HERE to show all gene set members

All member genes

	diab	PMX
Casc3	-213.0	8374.0
Col4a5	12326.0	7452.0
Cul2	-7656.0	2073.0
Dag1	14086.0	305.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Hoxa2	6369.0	2887.0
Ldb1	13326.0	-12215.0
Lhx2	9446.0	-6616.0
Lhx3	-665.5	3249.0
Lhx9	4055.0	-4216.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Msi1	13972.0	-10430.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Rbm8a2	-485.5	-1222.5
Rbx1	2286.0	4532.0
Rnps1	11263.0	-12563.0
Robo1	4284.0	7975.0
Robo2	-10164.0	12956.0
Robo3	-12220.0	10440.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Slit1	10290.0	-10823.0
Slit2	-9878.0	9321.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0
Usp33	-8958.0	-3443.0
Zswim8	12845.0	-11226.0

---

---

Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)

Nonsense-Mediated-Decay-(NMD)-enhanced-by-the-Exon-Junction-Complex-(EJC)

metric	value
setSize	99
pMANOVA	5.66e-23
p.adjustMANOVA	4.66e-21
s.dist	0.758
s.diab	0.507
s.PMX	-0.564
p.diab	2.59e-18
p.PMX	2.75e-22

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Casc3	-213.0	8374.0
Dcp1a	-6339.0	-22.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Pnrc2	-2276.0	-10147.0
Ppp2ca	2443.0	326.0
Ppp2r1a	11507.0	3755.0
Ppp2r2a	-1142.0	-9444.0
Rbm8a2	-485.5	-1222.5
Rnps1	11263.0	-12563.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Smg1	8862.0	-12241.0
Smg5	-7764.0	7622.0
Smg6	7235.0	-5765.0
Smg7	-83.0	2903.0
Smg8	4295.0	2512.0
Smg9	-8087.0	9030.0
Uba52	4596.0	-6796.0
Upf1	-11946.0	12557.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0

---

---

Nonsense-Mediated-Decay-(NMD)

Nonsense-Mediated-Decay-(NMD)

metric	value
setSize	99
pMANOVA	5.66e-23
p.adjustMANOVA	4.66e-21
s.dist	0.758
s.diab	0.507
s.PMX	-0.564
p.diab	2.59e-18
p.PMX	2.75e-22

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Casc3	-213.0	8374.0
Dcp1a	-6339.0	-22.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Etf1	11859.0	-13240.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Pabpc2	1803.5	5051.0
Pnrc2	-2276.0	-10147.0
Ppp2ca	2443.0	326.0
Ppp2r1a	11507.0	3755.0
Ppp2r2a	-1142.0	-9444.0
Rbm8a2	-485.5	-1222.5
Rnps1	11263.0	-12563.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Smg1	8862.0	-12241.0
Smg5	-7764.0	7622.0
Smg6	7235.0	-5765.0
Smg7	-83.0	2903.0
Smg8	4295.0	2512.0
Smg9	-8087.0	9030.0
Uba52	4596.0	-6796.0
Upf1	-11946.0	12557.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0

---

---

Selenoamino-acid-metabolism

Selenoamino-acid-metabolism

metric	value
setSize	91
pMANOVA	3.37e-21
p.adjustMANOVA	2.63e-19
s.dist	0.756
s.diab	0.496
s.PMX	-0.57
p.diab	2.52e-16
p.PMX	5.2e-21

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcy	-6297.0	-13572.0
Aimp1	10685.0	-10801.0
Aimp2	3346.0	9731.0
Cbs	-12747.0	12807.0
Cth	13940.0	-15012.0
Eefsec	-7997.0	11830.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnmt	-4555.0	5322.0
Gsr	3160.0	8021.0
Hnmt	-6205.0	-4283.0
Inmt	-12551.0	12151.0
Mat1a	4223.0	-12815.0
Nnmt	11136.0	-12817.0
Papss1	-8777.0	11499.0
Papss2	12971.0	-12114.0
Pstk	-9537.0	9420.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Scly	-9905.0	9810.0
Secisbp2	-9337.0	10086.0
Sephs2	-10506.0	11018.0
Sepsecs	-12324.0	11433.0
Txnrd1	-10298.0	11671.0
Uba52	4596.0	-6796.0

---

---

Influenza-Infection

Influenza-Infection

metric	value
setSize	134
pMANOVA	1.07e-20
p.adjustMANOVA	7.91e-19
s.dist	0.62
s.diab	0.423
s.PMX	-0.454
p.diab	2.72e-17
p.PMX	1.05e-19

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396
Rps25	14734	-14632

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Calr	-12155.0	11400.0
Canx	-11724.0	5539.0
Clta	-6346.0	5123.0
Cltc	8328.0	-9844.0
Cpsf4	5771.0	-8596.0
Dnajc3	-9188.0	-13392.0
Eif2ak2	12800.0	-13739.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Grsf1	9214.0	-9055.0
Gtf2f1	10842.0	-11838.0
Gtf2f2	11210.0	-13043.0
Hsp90aa1	-12505.0	4614.0
Hspa1b	13713.0	-5345.0
Ipo5	11718.0	-12610.0
Isg15	7447.0	-9094.0
Kpna1	7639.0	-11114.0
Kpna2	-6529.0	3386.0
Kpna3	11006.0	-12959.0
Kpna4	-12402.0	11649.0
Kpnb1	10908.0	1199.0
Ndc1	13238.0	-12109.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Parp1	-4209.0	11584.0
Polr2a	5917.0	6827.0
Polr2b	-9995.0	7496.0
Polr2c	-2600.0	9289.0
Polr2d	-4100.0	39.0
Polr2e	11726.0	-9159.0
Polr2f	11374.0	-6543.0
Polr2g	11118.0	-13257.0
Polr2h	224.0	-7426.0
Polr2i	13554.0	-12640.0
Polr2j	9902.0	-6099.0
Polr2k	7520.0	-11503.0
Polr2l	6213.0	4463.0
Pom121	9659.0	-12785.0
Rae1	-2818.0	7959.0
Ran	-340.0	-458.0
Ranbp2	-1884.0	-9227.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Tgfb1	-11489.0	7819.0
Tpr	-7568.0	-3358.0
Uba52	4596.0	-6796.0
Xpo1	-10778.0	9680.0

---

---

The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport

The-citric-acid-(TCA)-cycle-and-respiratory-electron-transport

metric	value
setSize	155
pMANOVA	3.99e-20
p.adjustMANOVA	2.82e-18
s.dist	0.554
s.diab	0.344
s.PMX	-0.434
p.diab	1.3e-13
p.PMX	8.78e-21

Top 20 genes

Gene	diab	PMX
Nnt	15395	-15153
Pdk1	15240	-15026
Uqcrb	15145	-15118
Uqcrh	15179	-15073
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Cox6b1	15253	-14902
Cox6c	15087	-15036
Sdhd	15189	-14923
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Cox5a	15090	-14747
Uqcrq	15160	-14637
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Cox7c	14740	-14896
Uqcr10	14874	-14710
Ndufb11	14492	-14964
Aco2	15080	-14219
Ndufa9	14469	-14794

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100.0	-9605.0
Aco2	15080.0	-14219.0
Adhfe1	-12630.0	11500.0
Bsg	10831.0	-9772.0
Coq10a	6677.0	7304.0
Coq10b	-10247.0	-10904.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Cs	14592.0	-10223.0
Cyc1	13836.0	-13962.0
Cycs	8402.0	-13138.0
D2hgdh	-12310.0	8579.0
Dlat	11467.0	-7817.0
Dld	5477.0	-13041.0
Dlst	10927.0	-8985.0
Ecsit	-9099.0	9725.0
Etfa	-9804.0	-7984.0
Etfb	11075.0	-11149.0
Etfdh	-1913.0	-8426.0
Fahd1	-11442.0	10570.0
Fh1	14053.0	-14546.0
Glo1	-6526.0	-5471.0
Gm11273	8317.0	-6691.0
Gstz1	-11792.0	8690.0
Hagh	13540.0	-13830.0
Idh2	4708.0	-8898.0
Idh3a	12635.0	-11295.0
Idh3b	11502.0	-11793.0
Idh3g	4738.0	-13228.0
L2hgdh	-11075.0	10714.0
Ldha	-5817.0	-9456.0
Ldhal6b	-4601.0	344.0
Ldhb	13267.0	4503.0
Lrpprc	12946.0	-11138.0
Mdh2	14022.0	-13258.0
Me1	-12638.0	12081.0
Me2	13676.0	5847.0
Me3	10234.0	-4629.0
Mpc1	-8891.0	-4807.0
Mpc2	9933.0	-14059.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Ndufa1	6937.0	-8412.0
Ndufa10	11110.0	-8885.0
Ndufa11	14920.0	-14266.0
Ndufa12	14903.0	-14234.0
Ndufa13	14115.0	-14226.0
Ndufa2	13627.0	-14858.0
Ndufa3	14864.0	-14832.0
Ndufa4	9874.0	-14669.0
Ndufa5	15074.0	-14984.0
Ndufa6	14999.0	-14781.0
Ndufa7	15178.0	-15058.0
Ndufa8	13665.0	-11997.0
Ndufa9	14469.0	-14794.0
Ndufab1	3106.0	-9458.0
Ndufaf1	-11416.0	10941.0
Ndufaf2	7440.0	-8823.0
Ndufaf3	367.0	-9795.0
Ndufaf4	-10599.0	6962.0
Ndufaf5	11575.0	-3621.0
Ndufaf6	333.0	-11082.0
Ndufaf7	9013.0	1113.0
Ndufb10	14262.0	-14459.0
Ndufb11	14492.0	-14964.0
Ndufb2	-4388.0	-8058.0
Ndufb3	12259.0	-14461.0
Ndufb4	9233.0	-12329.0
Ndufb5	14481.0	-14745.0
Ndufb6	14565.0	-13471.0
Ndufb7	13625.0	-13723.0
Ndufb9	15350.0	-14839.0
Ndufc1	14230.0	-14172.0
Ndufc2	13402.0	-13866.0
Ndufs1	7192.0	-12095.0
Ndufs2	14590.0	-13546.0
Ndufs3	14315.0	-14178.0
Ndufs4	14110.0	-14049.0
Ndufs5	13994.0	-14136.0
Ndufs6	14367.0	-14846.0
Ndufs7	11801.0	-14074.0
Ndufs8	12503.0	-14256.0
Ndufv1	7781.0	-368.0
Ndufv2	15041.0	-14992.0
Ndufv3	8348.0	4422.0
Nnt	15395.0	-15153.0
Nubpl	-8841.0	6873.0
Ogdh	12207.0	-6438.0
Pdha1	10727.0	-14169.0
Pdhb	13003.0	-14216.0
Pdhx	2479.0	6526.0
Pdk1	15240.0	-15026.0
Pdk2	14561.0	-9436.0
Pdk3	-11623.0	5982.0
Pdk4	9148.0	-14877.0
Pdp1	13244.0	-14167.0
Pdp2	-12232.0	12954.0
Pdpr	-11101.0	5405.0
Pm20d1	-11824.0	12257.0
Ppard	-9556.0	12160.0
Rxra	78.0	-5092.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sdha	7583.0	-6150.0
Sdhb	14750.0	-14069.0
Sdhc	-6156.0	-7176.0
Sdhd	15189.0	-14923.0
Slc16a1	14346.0	-8035.0
Slc16a3	11553.0	-11018.0
Slc16a8	11805.0	-13519.0
Slc25a14	-5941.0	2591.0
Slc25a27	7582.0	-4450.0
Sucla2	275.0	-12058.0
Suclg1	12169.0	-12783.0
Suclg2	-7679.0	5102.0
Surf1	10929.0	-8571.0
Taco1	-5127.0	3445.0
Timmdc1	-7729.0	8038.0
Tmem126b	-11814.0	6995.0
Tmem186	-10081.0	10176.0
Trap1	-11794.0	8106.0
Ucp1	2923.0	-2898.0
Ucp2	14325.0	-14886.0
Ucp3	10070.0	-13365.0
Uqcr10	14874.0	-14710.0
Uqcr11	13121.0	-13943.0
Uqcrb	15145.0	-15118.0
Uqcrc1	12486.0	-6849.0
Uqcrc2	12361.0	-13694.0
Uqcrfs1	11242.0	-12436.0
Uqcrh	15179.0	-15073.0
Uqcrq	15160.0	-14637.0
Vdac1	2808.0	-11375.0

---

---

Respiratory-electron-transport

Respiratory-electron-transport

metric	value
setSize	99
pMANOVA	3.24e-19
p.adjustMANOVA	2.19e-17
s.dist	0.681
s.diab	0.43
s.PMX	-0.527
p.diab	1.31e-13
p.PMX	1.07e-19

Top 20 genes

Gene	diab	PMX
Uqcrb	15145	-15118
Uqcrh	15179	-15073
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Cox6b1	15253	-14902
Cox6c	15087	-15036
Sdhd	15189	-14923
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Cox5a	15090	-14747
Uqcrq	15160	-14637
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Cox7c	14740	-14896
Uqcr10	14874	-14710
Ndufb11	14492	-14964
Ndufa9	14469	-14794
Ndufb5	14481	-14745
Ndufs6	14367	-14846
Ndufa11	14920	-14266

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100.0	-9605.0
Coq10a	6677.0	7304.0
Coq10b	-10247.0	-10904.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Cyc1	13836.0	-13962.0
Cycs	8402.0	-13138.0
Ecsit	-9099.0	9725.0
Etfa	-9804.0	-7984.0
Etfb	11075.0	-11149.0
Etfdh	-1913.0	-8426.0
Gm11273	8317.0	-6691.0
Lrpprc	12946.0	-11138.0
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Ndufa1	6937.0	-8412.0
Ndufa10	11110.0	-8885.0
Ndufa11	14920.0	-14266.0
Ndufa12	14903.0	-14234.0
Ndufa13	14115.0	-14226.0
Ndufa2	13627.0	-14858.0
Ndufa3	14864.0	-14832.0
Ndufa4	9874.0	-14669.0
Ndufa5	15074.0	-14984.0
Ndufa6	14999.0	-14781.0
Ndufa7	15178.0	-15058.0
Ndufa8	13665.0	-11997.0
Ndufa9	14469.0	-14794.0
Ndufab1	3106.0	-9458.0
Ndufaf1	-11416.0	10941.0
Ndufaf2	7440.0	-8823.0
Ndufaf3	367.0	-9795.0
Ndufaf4	-10599.0	6962.0
Ndufaf5	11575.0	-3621.0
Ndufaf6	333.0	-11082.0
Ndufaf7	9013.0	1113.0
Ndufb10	14262.0	-14459.0
Ndufb11	14492.0	-14964.0
Ndufb2	-4388.0	-8058.0
Ndufb3	12259.0	-14461.0
Ndufb4	9233.0	-12329.0
Ndufb5	14481.0	-14745.0
Ndufb6	14565.0	-13471.0
Ndufb7	13625.0	-13723.0
Ndufb9	15350.0	-14839.0
Ndufc1	14230.0	-14172.0
Ndufc2	13402.0	-13866.0
Ndufs1	7192.0	-12095.0
Ndufs2	14590.0	-13546.0
Ndufs3	14315.0	-14178.0
Ndufs4	14110.0	-14049.0
Ndufs5	13994.0	-14136.0
Ndufs6	14367.0	-14846.0
Ndufs7	11801.0	-14074.0
Ndufs8	12503.0	-14256.0
Ndufv1	7781.0	-368.0
Ndufv2	15041.0	-14992.0
Ndufv3	8348.0	4422.0
Nubpl	-8841.0	6873.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sdha	7583.0	-6150.0
Sdhb	14750.0	-14069.0
Sdhc	-6156.0	-7176.0
Sdhd	15189.0	-14923.0
Surf1	10929.0	-8571.0
Taco1	-5127.0	3445.0
Timmdc1	-7729.0	8038.0
Tmem126b	-11814.0	6995.0
Tmem186	-10081.0	10176.0
Trap1	-11794.0	8106.0
Uqcr10	14874.0	-14710.0
Uqcr11	13121.0	-13943.0
Uqcrb	15145.0	-15118.0
Uqcrc1	12486.0	-6849.0
Uqcrc2	12361.0	-13694.0
Uqcrfs1	11242.0	-12436.0
Uqcrh	15179.0	-15073.0
Uqcrq	15160.0	-14637.0

---

---

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

Respiratory-electron-transport,-ATP-synthesis-by-chemiosmotic-coupling,-and-heat-production-by-uncoupling-proteins.

metric	value
setSize	107
pMANOVA	1.42e-18
p.adjustMANOVA	9.15e-17
s.dist	0.643
s.diab	0.406
s.PMX	-0.499
p.diab	3.53e-13
p.PMX	4.52e-19

Top 20 genes

Gene	diab	PMX
Uqcrb	15145	-15118
Uqcrh	15179	-15073
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Cox6b1	15253	-14902
Cox6c	15087	-15036
Sdhd	15189	-14923
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Cox5a	15090	-14747
Uqcrq	15160	-14637
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Cox7c	14740	-14896
Uqcr10	14874	-14710
Ndufb11	14492	-14964
Ndufa9	14469	-14794
Ndufb5	14481	-14745
Ndufs6	14367	-14846
Ucp2	14325	-14886

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100.0	-9605.0
Coq10a	6677.0	7304.0
Coq10b	-10247.0	-10904.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Cyc1	13836.0	-13962.0
Cycs	8402.0	-13138.0
Ecsit	-9099.0	9725.0
Etfa	-9804.0	-7984.0
Etfb	11075.0	-11149.0
Etfdh	-1913.0	-8426.0
Gm11273	8317.0	-6691.0
Lrpprc	12946.0	-11138.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Ndufa1	6937.0	-8412.0
Ndufa10	11110.0	-8885.0
Ndufa11	14920.0	-14266.0
Ndufa12	14903.0	-14234.0
Ndufa13	14115.0	-14226.0
Ndufa2	13627.0	-14858.0
Ndufa3	14864.0	-14832.0
Ndufa4	9874.0	-14669.0
Ndufa5	15074.0	-14984.0
Ndufa6	14999.0	-14781.0
Ndufa7	15178.0	-15058.0
Ndufa8	13665.0	-11997.0
Ndufa9	14469.0	-14794.0
Ndufab1	3106.0	-9458.0
Ndufaf1	-11416.0	10941.0
Ndufaf2	7440.0	-8823.0
Ndufaf3	367.0	-9795.0
Ndufaf4	-10599.0	6962.0
Ndufaf5	11575.0	-3621.0
Ndufaf6	333.0	-11082.0
Ndufaf7	9013.0	1113.0
Ndufb10	14262.0	-14459.0
Ndufb11	14492.0	-14964.0
Ndufb2	-4388.0	-8058.0
Ndufb3	12259.0	-14461.0
Ndufb4	9233.0	-12329.0
Ndufb5	14481.0	-14745.0
Ndufb6	14565.0	-13471.0
Ndufb7	13625.0	-13723.0
Ndufb9	15350.0	-14839.0
Ndufc1	14230.0	-14172.0
Ndufc2	13402.0	-13866.0
Ndufs1	7192.0	-12095.0
Ndufs2	14590.0	-13546.0
Ndufs3	14315.0	-14178.0
Ndufs4	14110.0	-14049.0
Ndufs5	13994.0	-14136.0
Ndufs6	14367.0	-14846.0
Ndufs7	11801.0	-14074.0
Ndufs8	12503.0	-14256.0
Ndufv1	7781.0	-368.0
Ndufv2	15041.0	-14992.0
Ndufv3	8348.0	4422.0
Nubpl	-8841.0	6873.0
Pm20d1	-11824.0	12257.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sdha	7583.0	-6150.0
Sdhb	14750.0	-14069.0
Sdhc	-6156.0	-7176.0
Sdhd	15189.0	-14923.0
Slc25a14	-5941.0	2591.0
Slc25a27	7582.0	-4450.0
Surf1	10929.0	-8571.0
Taco1	-5127.0	3445.0
Timmdc1	-7729.0	8038.0
Tmem126b	-11814.0	6995.0
Tmem186	-10081.0	10176.0
Trap1	-11794.0	8106.0
Ucp1	2923.0	-2898.0
Ucp2	14325.0	-14886.0
Ucp3	10070.0	-13365.0
Uqcr10	14874.0	-14710.0
Uqcr11	13121.0	-13943.0
Uqcrb	15145.0	-15118.0
Uqcrc1	12486.0	-6849.0
Uqcrc2	12361.0	-13694.0
Uqcrfs1	11242.0	-12436.0
Uqcrh	15179.0	-15073.0
Uqcrq	15160.0	-14637.0

---

---

Signaling-by-ROBO-receptors

Signaling-by-ROBO-receptors

metric	value
setSize	192
pMANOVA	3.39e-18
p.adjustMANOVA	2.1e-16
s.dist	0.478
s.diab	0.306
s.PMX	-0.367
p.diab	2.26e-13
p.PMX	1.58e-18

Top 20 genes

Gene	diab	PMX
Gpc1	15341	-15137
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Psmd8	14709	-14720

Click HERE to show all gene set members

All member genes

	diab	PMX
Abl1	6603.0	-4424.0
Abl2	-288.0	-9898.0
Akap5	13260.0	-8998.0
Arhgap39	-10187.0	12166.0
Cap1	4211.0	6948.0
Cap2	3090.0	10302.0
Casc3	-213.0	8374.0
Cdc42	-243.0	-9562.0
Clasp1	8043.0	-6017.0
Clasp2	14039.0	-9470.0
Col4a5	12326.0	7452.0
Cul2	-7656.0	2073.0
Cxcl12	-241.0	6950.0
Cxcr4	7466.0	-10281.0
Dag1	14086.0	305.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Enah	14569.0	-14563.0
Etf1	11859.0	-13240.0
Evl	-8437.0	11927.0
Flrt3	-7375.0	-4075.0
Flt3l	-10231.0	11283.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gpc1	15341.0	-15137.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Hoxa2	6369.0	2887.0
Ldb1	13326.0	-12215.0
Lhx2	9446.0	-6616.0
Lhx3	-665.5	3249.0
Lhx9	4055.0	-4216.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Msi1	13972.0	-10430.0
Myo9b	4209.0	8589.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Nck1	-4016.0	-10473.0
Nck2	-5920.0	1627.0
Nell2	9389.0	7424.0
Nrp1	-10538.0	3551.0
Ntn1	-12657.0	12445.0
Pabpc2	1803.5	5051.0
Pak1	9007.0	-10571.0
Pak2	-11115.0	10419.0
Pak3	9025.0	-9081.0
Pak4	2963.0	-7078.0
Pak6	13683.0	-13884.0
Pak7	-6905.0	2039.0
Pfn1	-2444.0	4731.0
Pfn2	14209.0	-14087.0
Ppp3cb	-6472.0	4604.0
Prkaca	-8030.0	10329.0
Prkacb	-256.0	3728.0
Prkar2a	13537.0	-12751.0
Prkca	-11577.0	11021.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Rac1	-4047.0	262.0
Rbm8a2	-485.5	-1222.5
Rbx1	2286.0	4532.0
Rnps1	11263.0	-12563.0
Robo1	4284.0	7975.0
Robo2	-10164.0	12956.0
Robo3	-12220.0	10440.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Slit1	10290.0	-10823.0
Slit2	-9878.0	9321.0
Slit3	12952.0	-6476.0
Sos1	-11977.0	9665.0
Sos2	-5483.0	3046.0
Src	8646.0	4243.0
Srgap1	9493.0	11288.0
Srgap2	10271.0	-10418.0
Srgap3	14988.0	-14259.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0
Usp33	-8958.0	-3443.0
Vasp	-3832.0	4449.0
Zswim8	12845.0	-11226.0

---

---

Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex

Formation-of-the-ternary-complex,-and-subsequently,-the-43S-complex

metric	value
setSize	46
pMANOVA	2.88e-17
p.adjustMANOVA	1.71e-15
s.dist	0.963
s.diab	0.66
s.PMX	-0.701
p.diab	9.2e-15
p.PMX	1.88e-16

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305
Rpsa	15188	-13108

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol

Major-pathway-of-rRNA-processing-in-the-nucleolus-and-cytosol

metric	value
setSize	162
pMANOVA	6.41e-17
p.adjustMANOVA	3.65e-15
s.dist	0.492
s.diab	0.3
s.PMX	-0.39
p.diab	4.39e-11
p.PMX	9.57e-18

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Utp20	15103	-15017
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Bms1	7917.0	-7605.0
Bop1	-8108.0	8532.0
Bysl	-5612.0	9140.0
C1d	-6714.0	-2249.0
Cirh1a	10469.0	-8005.0
Csnk1d	4297.0	-10796.0
Csnk1e	10966.0	-7406.0
Dcaf13	7110.0	-10317.0
Ddx21	-7792.0	2669.0
Ddx47	13049.0	-11830.0
Ddx49	11080.0	-6073.0
Ddx52	-8860.0	-9533.0
Dhx37	-6165.0	10848.0
Diexf	-5014.0	6709.0
Dis3	-10317.0	11084.0
Ebna1bp2	6632.0	4411.0
Emg1	-9703.0	4611.0
Eri1	-9108.0	2577.0
Exosc1	-1652.0	-259.0
Exosc10	8632.0	5484.0
Exosc2	-4051.0	7454.0
Exosc3	-9773.0	11565.0
Exosc4	-6162.0	8972.0
Exosc5	-4859.0	4528.0
Exosc7	12464.0	-11384.0
Exosc8	-4592.0	-5642.0
Exosc9	14145.0	-12668.0
Fbl	-4932.0	5426.0
Fcf1	13630.0	-14163.0
Flt3l	-10231.0	11283.0
Ftsj3	3001.0	-6694.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnl3	10096.0	-12819.0
Heatr1	-11338.0	10893.0
Imp3	-5609.0	-8567.0
Imp4	8324.0	4833.0
Isg20l2	-7238.0	-230.0
Krr1	-3106.0	-6324.0
Las1l	12051.0	-9689.0
Ltv1	5893.0	2046.0
Mphosph10	-2542.0	-11771.0
Mphosph6	10241.0	-11218.0
Ncl	14307.0	-13602.0
Nhp2l1	6307.0	-58.0
Nip7	13271.0	-13751.0
Nob1	-4352.0	-9473.0
Noc4l	10740.0	-5347.0
Nol11	-4875.0	8721.0
Nol12	-2586.0	7084.0
Nol6	8470.0	9046.0
Nol9	-11143.0	10670.0
Nop14	6664.0	-10954.0
Nop56	-4290.0	-9085.0
Nop58	-6387.0	-12931.0
Pdcd11	-11181.0	12247.0
Pelp1	-87.0	8998.0
Pes1	12388.0	-11115.0
Pno1	9553.0	-8568.0
Pwp2	-10371.0	9002.0
Rbm28	-8925.0	7344.0
Rcl1	4228.0	-12272.0
Riok1	10886.0	-12644.0
Riok3	12673.0	-11776.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpp14	-4004.0	7707.0
Rpp21	13040.0	-10953.0
Rpp25	12542.0	-12010.0
Rpp30	-3330.0	-5143.0
Rpp38	12569.0	-5312.0
Rpp40	-11849.0	12707.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rrp1	12048.0	-7129.0
Rrp36	-3406.0	4080.0
Rrp7a	-8269.0	9929.0
Rrp9	-8119.0	5583.0
Senp3	3387.0	-3767.0
Tbl3	11187.0	-4755.0
Tex10	13888.0	-13152.0
Tsr1	-1495.0	-3588.0
Uba52	4596.0	-6796.0
Utp11l	-7005.0	-4860.0
Utp14a	-5133.0	-2742.0
Utp15	5938.0	1712.0
Utp18	-7826.0	-6737.0
Utp20	15103.0	-15017.0
Utp3	10392.0	-12353.0
Utp6	-11407.0	9055.0
Wbscr22	-8122.0	9241.0
Wdr12	-7739.0	-6258.0
Wdr18	-9867.0	7547.0
Wdr3	-9605.0	8188.0
Wdr36	-8873.0	-4579.0
Wdr43	12457.0	-11762.0
Wdr46	-6655.0	10606.0
Wdr75	-8085.0	372.0
Xrn2	12991.0	-13905.0

---

---

Ribosomal-scanning-and-start-codon-recognition

Ribosomal-scanning-and-start-codon-recognition

metric	value
setSize	53
pMANOVA	1.26e-15
p.adjustMANOVA	6.9e-14
s.dist	0.841
s.diab	0.545
s.PMX	-0.641
p.diab	6.61e-12
p.PMX	6.6e-16

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305
Rpsa	15188	-13108

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Eif4a1	3248.0	-13189
Eif4a2	-10764.0	-7297
Eif4b	-10769.0	8501
Eif4e	-6639.0	-8178
Eif4g1	-7805.0	7417
Eif4h	9857.0	-5981
Eif5	11068.0	-12964
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

rRNA-processing

rRNA-processing

metric	value
setSize	191
pMANOVA	1.49e-15
p.adjustMANOVA	7.91e-14
s.dist	0.434
s.diab	0.265
s.PMX	-0.344
p.diab	2.63e-10
p.PMX	2.28e-16

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Utp20	15103	-15017
Rps17	14996	-14975
Nop10	14932	-15027
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690

Click HERE to show all gene set members

All member genes

	diab	PMX
Bms1	7917.0	-7605.0
Bop1	-8108.0	8532.0
Bysl	-5612.0	9140.0
C1d	-6714.0	-2249.0
Cirh1a	10469.0	-8005.0
Csnk1d	4297.0	-10796.0
Csnk1e	10966.0	-7406.0
Dcaf13	7110.0	-10317.0
Ddx21	-7792.0	2669.0
Ddx47	13049.0	-11830.0
Ddx49	11080.0	-6073.0
Ddx52	-8860.0	-9533.0
Dhx37	-6165.0	10848.0
Diexf	-5014.0	6709.0
Dimt1	5090.0	-59.0
Dis3	-10317.0	11084.0
Dkc1	-9010.0	7070.0
Ebna1bp2	6632.0	4411.0
Elac2	5026.0	5862.0
Emg1	-9703.0	4611.0
Eri1	-9108.0	2577.0
Exosc1	-1652.0	-259.0
Exosc10	8632.0	5484.0
Exosc2	-4051.0	7454.0
Exosc3	-9773.0	11565.0
Exosc4	-6162.0	8972.0
Exosc5	-4859.0	4528.0
Exosc7	12464.0	-11384.0
Exosc8	-4592.0	-5642.0
Exosc9	14145.0	-12668.0
Fbl	-4932.0	5426.0
Fcf1	13630.0	-14163.0
Flt3l	-10231.0	11283.0
Ftsj3	3001.0	-6694.0
Gar1	-5704.0	-2440.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnl3	10096.0	-12819.0
Heatr1	-11338.0	10893.0
Hsd17b10	13714.0	-13444.0
Imp3	-5609.0	-8567.0
Imp4	8324.0	4833.0
Isg20l2	-7238.0	-230.0
Krr1	-3106.0	-6324.0
Las1l	12051.0	-9689.0
Ltv1	5893.0	2046.0
Mphosph10	-2542.0	-11771.0
Mphosph6	10241.0	-11218.0
Mrm1	8173.0	6939.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
Mterf4	4577.0	-5671.0
Nat10	-3010.0	4903.0
Ncl	14307.0	-13602.0
Nhp2	-4543.0	-7331.0
Nhp2l1	6307.0	-58.0
Nip7	13271.0	-13751.0
Nob1	-4352.0	-9473.0
Noc4l	10740.0	-5347.0
Nol11	-4875.0	8721.0
Nol12	-2586.0	7084.0
Nol6	8470.0	9046.0
Nol9	-11143.0	10670.0
Nop10	14932.0	-15027.0
Nop14	6664.0	-10954.0
Nop2	-11173.0	12322.0
Nop56	-4290.0	-9085.0
Nop58	-6387.0	-12931.0
Nsun4	-2625.0	-8489.0
Pdcd11	-11181.0	12247.0
Pelp1	-87.0	8998.0
Pes1	12388.0	-11115.0
Pno1	9553.0	-8568.0
Pwp2	-10371.0	9002.0
Rbm28	-8925.0	7344.0
Rcl1	4228.0	-12272.0
Riok1	10886.0	-12644.0
Riok3	12673.0	-11776.0
Rnmtl1	-9443.0	9410.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpp14	-4004.0	7707.0
Rpp21	13040.0	-10953.0
Rpp25	12542.0	-12010.0
Rpp30	-3330.0	-5143.0
Rpp38	12569.0	-5312.0
Rpp40	-11849.0	12707.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rrp1	12048.0	-7129.0
Rrp36	-3406.0	4080.0
Rrp7a	-8269.0	9929.0
Rrp9	-8119.0	5583.0
Senp3	3387.0	-3767.0
Tbl3	11187.0	-4755.0
Tex10	13888.0	-13152.0
Tfb1m	-8554.0	11928.0
Thumpd1	-5611.0	5187.0
Trmt10c	-8268.0	-8771.0
Trmt112	-11645.0	12227.0
Tsr1	-1495.0	-3588.0
Tsr3	3631.0	2131.0
Uba52	4596.0	-6796.0
Utp11l	-7005.0	-4860.0
Utp14a	-5133.0	-2742.0
Utp15	5938.0	1712.0
Utp18	-7826.0	-6737.0
Utp20	15103.0	-15017.0
Utp3	10392.0	-12353.0
Utp6	-11407.0	9055.0
Wbscr22	-8122.0	9241.0
Wdr12	-7739.0	-6258.0
Wdr18	-9867.0	7547.0
Wdr3	-9605.0	8188.0
Wdr36	-8873.0	-4579.0
Wdr43	12457.0	-11762.0
Wdr46	-6655.0	10606.0
Wdr75	-8085.0	372.0
Xrn2	12991.0	-13905.0

---

---

Translation

Translation

metric	value
setSize	255
pMANOVA	1.99e-15
p.adjustMANOVA	1.02e-13
s.dist	0.367
s.diab	0.213
s.PMX	-0.298
p.diab	4.53e-09
p.PMX	2.01e-16

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Eif4ebp1	15028	-14599
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690
Rps8	15035	-14396

Click HERE to show all gene set members

All member genes

	diab	PMX
Aars2	3152.0	6044.0
Aimp1	10685.0	-10801.0
Aimp2	3346.0	9731.0
Apeh	-11381.0	10100.0
Aurkaip1	14167.0	-13924.0
Cars2	-9513.0	11616.0
Chchd1	13076.0	-13755.0
Dap3	13409.0	-14626.0
Dars2	-10385.0	364.0
Ddost	-11311.0	11142.0
Ears2	-11491.0	12252.0
Eef1a1	6403.0	-13665.0
Eef1a2	10648.0	-10014.0
Eef1b2	14272.0	-14363.0
Eef1d	-8373.0	5588.0
Eef1g	-8453.0	9394.0
Eef2	-8913.0	4813.0
Eif1ax	-5466.0	-3602.0
Eif2b1	11279.0	-2807.0
Eif2b2	-5526.0	8016.0
Eif2b3	-275.0	-7159.0
Eif2b4	-5228.0	6620.0
Eif2b5	9058.0	8598.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Eif3a	-2940.0	-10671.0
Eif3b	370.0	8561.0
Eif3c	13657.0	-12370.0
Eif3d	6109.0	8089.0
Eif3e	-4624.0	-9641.0
Eif3f	12131.0	-12457.0
Eif3g	10673.0	-396.0
Eif3h	-5058.0	-8761.0
Eif3i	14318.0	-14250.0
Eif3j2	-3074.0	-255.0
Eif3k	14075.0	-13705.0
Eif3l	12887.0	5497.0
Eif3m	12598.0	-14034.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4ebp1	15028.0	-14599.0
Eif4g1	-7805.0	7417.0
Eif4h	9857.0	-5981.0
Eif5	11068.0	-12964.0
Eif5b	5738.0	-10419.0
Eral1	10477.0	-5806.0
Etf1	11859.0	-13240.0
Fars2	-6772.0	2553.0
Farsa	-8357.0	10146.0
Farsb	-11963.0	6794.0
Flt3l	-10231.0	11283.0
Gadd45gip1	-5424.0	2744.0
Gfm1	-8781.0	5192.0
Gfm2	-10403.0	5888.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Hars2	-10552.0	4750.0
Iars2	-8173.0	4030.0
Lars2	2973.0	-11810.0
Mars2	-10146.0	10260.0
Mrpl1	7968.0	5844.0
Mrpl10	-8377.0	6929.0
Mrpl11	13907.0	-11811.0
Mrpl12	-5514.0	-3518.0
Mrpl13	11017.0	-11307.0
Mrpl14	7370.0	1896.0
Mrpl15	3061.0	-8641.0
Mrpl16	-7951.0	8348.0
Mrpl17	-7086.0	208.0
Mrpl18	9737.0	-13625.0
Mrpl19	-6628.0	7652.0
Mrpl2	12137.0	3747.0
Mrpl20	14009.0	-14503.0
Mrpl21	10182.0	-11036.0
Mrpl22	8363.0	-11754.0
Mrpl23	4916.0	5066.0
Mrpl24	-6967.0	-2442.0
Mrpl27	13138.0	-10107.0
Mrpl28	4035.0	-9743.0
Mrpl3	-9993.0	11075.0
Mrpl30	14933.0	-14339.0
Mrpl32	7615.0	-9608.0
Mrpl33	12851.0	-6963.0
Mrpl34	6280.0	5256.0
Mrpl35	13312.0	-14252.0
Mrpl36	-10400.0	10284.0
Mrpl37	-1117.0	4298.0
Mrpl38	-5379.0	-6583.0
Mrpl39	6847.0	-13139.0
Mrpl4	-6778.0	6862.0
Mrpl40	9363.0	-3385.0
Mrpl41	7791.0	-6451.0
Mrpl42	13446.0	-13805.0
Mrpl43	-5506.0	8590.0
Mrpl44	-9369.0	8473.0
Mrpl45	6001.0	2586.0
Mrpl46	9434.0	-11850.0
Mrpl47	8880.0	-8392.0
Mrpl48	-1668.0	-10616.0
Mrpl49	-4408.0	7196.0
Mrpl50	-10799.0	1883.0
Mrpl51	-3926.0	-6093.0
Mrpl52	12134.0	-11611.0
Mrpl54	12729.0	-13688.0
Mrpl55	12696.0	-11968.0
Mrpl57	12690.0	-6055.0
Mrpl9	-3511.0	-10213.0
Mrps10	7888.0	-10664.0
Mrps11	2980.0	-8414.0
Mrps12	-10274.0	8806.0
Mrps14	8932.0	-12141.0
Mrps15	10000.0	-9610.0
Mrps16	10459.0	-7905.0
Mrps17	13086.0	-12441.0
Mrps18a	-5386.0	8223.0
Mrps18b	12728.0	-8548.0
Mrps18c	13821.0	-13464.0
Mrps2	-10692.0	11619.0
Mrps21	10809.0	-13693.0
Mrps22	-4154.0	-2336.0
Mrps23	10959.0	1562.0
Mrps24	13704.0	-14096.0
Mrps25	8273.0	-7172.0
Mrps26	10149.0	9009.0
Mrps27	3189.0	8943.0
Mrps28	12521.0	-12736.0
Mrps30	9131.0	-7551.0
Mrps31	7063.0	-8193.0
Mrps33	6174.0	-8848.0
Mrps34	7969.0	-2246.0
Mrps35	13357.0	-9285.0
Mrps36	8555.0	-8284.0
Mrps5	-5225.0	4653.0
Mrps6	13999.0	-14301.0
Mrps7	-9745.0	8133.0
Mrps9	14155.0	-14240.0
Mrrf	-3729.0	-205.0
Mtfmt	-3064.0	-6711.0
Mtif2	-7421.0	9330.0
Mtif3	-8823.0	7114.0
Mtrf1l	-9748.0	4451.0
N6amt1	-5072.0	10569.0
Nars2	-7825.0	11278.0
Oxa1l	-1486.0	10257.0
Pabpc2	1803.5	5051.0
Pars2	3022.0	-5996.0
Ppa1	13552.0	-14128.0
Ppa2	-10837.0	1791.0
Ptcd3	2433.0	-10373.0
Rars2	-10416.0	12229.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpn1	-12234.0	10781.0
Rpn2	-8531.0	4240.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sars2	7342.0	9250.0
Sec11a	-10050.0	-13192.0
Sec11c	6317.0	-11728.0
Sec61a1	-10632.0	9529.0
Sec61a2	2273.0	-12284.0
Sec61b	-6804.0	8046.0
Sec61g	2842.0	-5782.0
Spcs1	-9784.0	-9337.0
Spcs2	-11309.0	6712.0
Spcs3	6719.0	-10661.0
Srp14	10201.0	-11271.0
Srp19	-8639.0	-9543.0
Srp54a	-4764.0	766.0
Srp68	4472.0	-4510.0
Srp72	8797.0	-11367.0
Srp9	-1833.0	-7812.0
Srpr	10750.0	-13353.0
Srprb	3421.0	2100.0
Ssr1	-11725.0	10337.0
Ssr2	-8791.0	-2977.0
Ssr3	-933.0	-13076.0
Ssr4	11159.0	-13592.0
Tars2	-6710.0	11620.0
Tram1	-12409.0	9369.0
Trmt112	-11645.0	12227.0
Tsfm	-6977.0	8795.0
Tufm	-7989.0	4875.0
Uba52	4596.0	-6796.0
Vars2	-5375.0	1750.0
Wars2	-7250.0	9357.0
Yars2	-10916.0	8204.0

---

---

Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S

Activation-of-the-mRNA-upon-binding-of-the-cap-binding-complex-and-eIFs,-and-subsequent-binding-to-43S

metric	value
setSize	54
pMANOVA	3.11e-15
p.adjustMANOVA	1.53e-13
s.dist	0.825
s.diab	0.541
s.PMX	-0.623
p.diab	6.13e-12
p.PMX	2.24e-15

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Eif4ebp1	15028	-14599
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Eif4a1	3248.0	-13189
Eif4a2	-10764.0	-7297
Eif4b	-10769.0	8501
Eif4e	-6639.0	-8178
Eif4ebp1	15028.0	-14599
Eif4g1	-7805.0	7417
Eif4h	9857.0	-5981
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Pabpc2	1803.5	5051
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

rRNA-processing-in-the-nucleus-and-cytosol

rRNA-processing-in-the-nucleus-and-cytosol

metric	value
setSize	172
pMANOVA	6.74e-15
p.adjustMANOVA	3.22e-13
s.dist	0.444
s.diab	0.266
s.PMX	-0.355
p.diab	1.75e-09
p.PMX	8.42e-16

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Utp20	15103	-15017
Rps17	14996	-14975
Nop10	14932	-15027
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843
Rpl35	14822	-14690

Click HERE to show all gene set members

All member genes

	diab	PMX
Bms1	7917.0	-7605.0
Bop1	-8108.0	8532.0
Bysl	-5612.0	9140.0
C1d	-6714.0	-2249.0
Cirh1a	10469.0	-8005.0
Csnk1d	4297.0	-10796.0
Csnk1e	10966.0	-7406.0
Dcaf13	7110.0	-10317.0
Ddx21	-7792.0	2669.0
Ddx47	13049.0	-11830.0
Ddx49	11080.0	-6073.0
Ddx52	-8860.0	-9533.0
Dhx37	-6165.0	10848.0
Diexf	-5014.0	6709.0
Dimt1	5090.0	-59.0
Dis3	-10317.0	11084.0
Dkc1	-9010.0	7070.0
Ebna1bp2	6632.0	4411.0
Emg1	-9703.0	4611.0
Eri1	-9108.0	2577.0
Exosc1	-1652.0	-259.0
Exosc10	8632.0	5484.0
Exosc2	-4051.0	7454.0
Exosc3	-9773.0	11565.0
Exosc4	-6162.0	8972.0
Exosc5	-4859.0	4528.0
Exosc7	12464.0	-11384.0
Exosc8	-4592.0	-5642.0
Exosc9	14145.0	-12668.0
Fbl	-4932.0	5426.0
Fcf1	13630.0	-14163.0
Flt3l	-10231.0	11283.0
Ftsj3	3001.0	-6694.0
Gar1	-5704.0	-2440.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnl3	10096.0	-12819.0
Heatr1	-11338.0	10893.0
Imp3	-5609.0	-8567.0
Imp4	8324.0	4833.0
Isg20l2	-7238.0	-230.0
Krr1	-3106.0	-6324.0
Las1l	12051.0	-9689.0
Ltv1	5893.0	2046.0
Mphosph10	-2542.0	-11771.0
Mphosph6	10241.0	-11218.0
Nat10	-3010.0	4903.0
Ncl	14307.0	-13602.0
Nhp2	-4543.0	-7331.0
Nhp2l1	6307.0	-58.0
Nip7	13271.0	-13751.0
Nob1	-4352.0	-9473.0
Noc4l	10740.0	-5347.0
Nol11	-4875.0	8721.0
Nol12	-2586.0	7084.0
Nol6	8470.0	9046.0
Nol9	-11143.0	10670.0
Nop10	14932.0	-15027.0
Nop14	6664.0	-10954.0
Nop2	-11173.0	12322.0
Nop56	-4290.0	-9085.0
Nop58	-6387.0	-12931.0
Pdcd11	-11181.0	12247.0
Pelp1	-87.0	8998.0
Pes1	12388.0	-11115.0
Pno1	9553.0	-8568.0
Pwp2	-10371.0	9002.0
Rbm28	-8925.0	7344.0
Rcl1	4228.0	-12272.0
Riok1	10886.0	-12644.0
Riok3	12673.0	-11776.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpp14	-4004.0	7707.0
Rpp21	13040.0	-10953.0
Rpp25	12542.0	-12010.0
Rpp30	-3330.0	-5143.0
Rpp38	12569.0	-5312.0
Rpp40	-11849.0	12707.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rrp1	12048.0	-7129.0
Rrp36	-3406.0	4080.0
Rrp7a	-8269.0	9929.0
Rrp9	-8119.0	5583.0
Senp3	3387.0	-3767.0
Tbl3	11187.0	-4755.0
Tex10	13888.0	-13152.0
Thumpd1	-5611.0	5187.0
Trmt112	-11645.0	12227.0
Tsr1	-1495.0	-3588.0
Tsr3	3631.0	2131.0
Uba52	4596.0	-6796.0
Utp11l	-7005.0	-4860.0
Utp14a	-5133.0	-2742.0
Utp15	5938.0	1712.0
Utp18	-7826.0	-6737.0
Utp20	15103.0	-15017.0
Utp3	10392.0	-12353.0
Utp6	-11407.0	9055.0
Wbscr22	-8122.0	9241.0
Wdr12	-7739.0	-6258.0
Wdr18	-9867.0	7547.0
Wdr3	-9605.0	8188.0
Wdr36	-8873.0	-4579.0
Wdr43	12457.0	-11762.0
Wdr46	-6655.0	10606.0
Wdr75	-8085.0	372.0
Xrn2	12991.0	-13905.0

---

---

Translation-initiation-complex-formation

Translation-initiation-complex-formation

metric	value
setSize	53
pMANOVA	1.24e-14
p.adjustMANOVA	5.72e-13
s.dist	0.815
s.diab	0.532
s.PMX	-0.617
p.diab	1.96e-11
p.PMX	7.69e-15

Top 20 genes

Gene	diab	PMX
Rps11	15181	-14944
Rps17	14996	-14975
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rps29	14692	-15018
Rps23	14881	-14689
Rps21	14839	-14698
Rps8	15035	-14396
Rps25	14734	-14632
Rps20	14597	-14678
Rps3	14361	-14711
Rps5	14656	-14338
Rps27a	13894	-14715
Rps19	14632	-13971
Eif3i	14318	-14250
Rps27	13829	-14647
Rps18	14146	-14208
Rps7	13962	-14305
Rpsa	15188	-13108

Click HERE to show all gene set members

All member genes

	diab	PMX
Eif1ax	-5466.0	-3602
Eif2s1	3692.0	-6086
Eif2s2	11201.0	-14019
Eif2s3x	4982.0	-5754
Eif3a	-2940.0	-10671
Eif3b	370.0	8561
Eif3c	13657.0	-12370
Eif3d	6109.0	8089
Eif3e	-4624.0	-9641
Eif3f	12131.0	-12457
Eif3g	10673.0	-396
Eif3h	-5058.0	-8761
Eif3i	14318.0	-14250
Eif3j2	-3074.0	-255
Eif3k	14075.0	-13705
Eif3l	12887.0	5497
Eif3m	12598.0	-14034
Eif4a1	3248.0	-13189
Eif4a2	-10764.0	-7297
Eif4b	-10769.0	8501
Eif4e	-6639.0	-8178
Eif4g1	-7805.0	7417
Eif4h	9857.0	-5981
Gm10263	6260.5	-6620
Gm9843	8515.0	-10259
Pabpc2	1803.5	5051
Rps11	15181.0	-14944
Rps13	13052.0	-13020
Rps14	12707.0	-13299
Rps15a	12963.0	-13765
Rps16	15113.0	-14800
Rps17	14996.0	-14975
Rps18	14146.0	-14208
Rps19	14632.0	-13971
Rps20	14597.0	-14678
Rps21	14839.0	-14698
Rps23	14881.0	-14689
Rps24	15030.0	-14883
Rps25	14734.0	-14632
Rps26	15026.0	-14729
Rps27	13829.0	-14647
Rps27a	13894.0	-14715
Rps27l	13961.0	-12732
Rps29	14692.0	-15018
Rps3	14361.0	-14711
Rps3a1	10592.0	-13421
Rps4x	13560.0	-13892
Rps5	14656.0	-14338
Rps6	12437.0	-12720
Rps7	13962.0	-14305
Rps8	15035.0	-14396
Rps9	8708.0	-12306
Rpsa	15188.0	-13108

---

---

Metabolism-of-amino-acids-and-derivatives

Metabolism-of-amino-acids-and-derivatives

metric	value
setSize	335
pMANOVA	1.35e-13
p.adjustMANOVA	6.06e-12
s.dist	0.284
s.diab	0.147
s.PMX	-0.243
p.diab	3.54e-06
p.PMX	1.94e-14

Top 20 genes

Gene	diab	PMX
Glud1	15380	-15127
Bbox1	15339	-15141
Kynu	15385	-15087
Asrgl1	15370	-14930
Folh1	15352	-14926
Slc6a12	15137	-15079
Rplp1	15259	-14929
Rpl32	15195	-14957
Shmt1	15258	-14887
Rps11	15181	-14944
Gcsh	15232	-14871
Bhmt	15373	-14717
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Arg2	15043	-14789
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951

Click HERE to show all gene set members

All member genes

	diab	PMX
Aadat	-11810.0	8847.0
Aanat	-2109.5	2317.5
Aass	-11261.0	6694.0
Acad8	-8463.0	10460.0
Acadsb	7755.0	-5921.0
Acat1	-12750.0	12108.0
Acmsd	-11000.0	11260.0
Adi1	-8270.0	11019.0
Ado	-3981.0	8706.0
Afmid	-12623.0	12121.0
Agmat	-8595.0	11784.0
Agxt	2454.0	1966.0
Agxt2	-8255.0	-7637.0
Ahcy	-6297.0	-13572.0
Aimp1	10685.0	-10801.0
Aimp2	3346.0	9731.0
Aldh18a1	12016.0	-9762.0
Aldh4a1	10650.0	-4474.0
Aldh6a1	-12214.0	11149.0
Aldh7a1	-7596.0	9943.0
Aldh9a1	4156.0	-8886.0
Amd1	-11782.0	9516.0
Amdhd1	13013.0	-9775.0
Amt	14204.0	-9127.0
Apip	10598.0	-8306.0
Arg1	-4401.0	-6657.5
Arg2	15043.0	-14789.0
Asmt	-1605.0	4934.0
Asns	14974.0	-13140.0
Aspa	3473.0	-10542.0
Aspg	-9514.0	-4363.0
Asrgl1	15370.0	-14930.0
Ass1	-12485.0	12875.0
Auh	-3107.0	2097.0
Azin1	-9195.0	-11121.0
Azin2	13002.0	-8938.0
Bbox1	15339.0	-15141.0
Bcat1	-8105.0	-9482.0
Bcat2	10628.0	1717.0
Bckdha	-10102.0	11338.0
Bckdhb	-5600.0	-2924.0
Bckdk	-9640.0	9834.0
Bhmt	15373.0	-14717.0
Bhmt2	13948.0	-13849.0
Carnmt1	10294.0	-12262.0
Carns1	6176.0	1103.0
Cbs	-12747.0	12807.0
Cdo1	14140.0	-14368.0
Chdh	-12368.0	7161.0
Ckb	14356.0	-5744.0
Ckm	-4939.0	-5464.0
Ckmt1	15310.0	5970.0
Ckmt2	-4824.0	1414.0
Cps1	-2822.0	-13202.0
Crym	14306.0	-14651.0
Csad	-12263.0	10862.0
Cth	13940.0	-15012.0
Dao	-11927.0	12533.0
Dbh	-2109.5	2317.5
Dbt	-11658.0	9290.0
Dct	2483.5	1359.0
Ddc	15208.0	-7341.0
Ddo	-12459.0	12340.0
Dhtkd1	-11638.0	11406.0
Dio1	355.0	-12703.0
Dio2	-7785.0	1452.0
Dio3	-805.0	-8677.0
Dlat	11467.0	-7817.0
Dld	5477.0	-13041.0
Dlst	10927.0	-8985.0
Dmgdh	12087.0	-12209.0
Duox1	-6850.0	12109.0
Duox2	-6484.0	1308.0
Echs1	-1268.0	-11574.0
Eefsec	-7997.0	11830.0
Enoph1	9436.0	3697.0
Ethe1	-8843.0	12367.0
Fah	-11378.0	6288.0
Flt3l	-10231.0	11283.0
Folh1	15352.0	-14926.0
Ftcd	11369.0	10881.0
Gadl1	-892.5	3221.5
Gamt	-12204.0	10782.0
Gatm	14388.0	-10805.0
Gcat	-3834.0	8853.0
Gcdh	-9906.0	4382.0
Gcsh	15232.0	-14871.0
Gldc	14602.0	-14681.0
Gls	13744.0	-14134.0
Gls2	5942.0	60.0
Glud1	15380.0	-15127.0
Glul	14333.0	-14998.0
Gm10263	6260.5	-6620.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnmt	-4555.0	5322.0
Got1	15126.0	-14433.0
Got2	14120.0	-12201.0
Gpt	12659.0	3526.0
Gpt2	15224.0	-14057.0
Grhpr	-10339.0	11416.0
Gsr	3160.0	8021.0
Gstz1	-11792.0	8690.0
Haao	-11862.0	4642.0
Hal	-3038.0	-7759.0
Hao1	7741.0	-11214.0
Hdc	12931.0	-12335.0
Hgd	-2873.0	-6675.0
Hibadh	-12251.0	5564.0
Hibch	-5381.0	-10917.0
Hnmt	-6205.0	-4283.0
Hoga1	-3854.0	6390.0
Hpd	10836.0	-13526.0
Hsd17b10	13714.0	-13444.0
Hykk	-12766.0	12868.0
Ido1	9671.0	5429.0
Ido2	-9840.0	4.0
Il4i1	-9293.0	10683.0
Inmt	-12551.0	12151.0
Ivd	-12660.0	12018.0
Iyd	11391.0	-10347.0
Kmo	-10653.0	8379.0
Kynu	15385.0	-15087.0
Lias	3695.0	-8546.0
Lipt1	-11689.0	11665.0
Lipt2	-10418.0	8002.0
Mat1a	4223.0	-12815.0
Mccc1	-11486.0	11934.0
Mccc2	-8722.0	-8808.0
Mpst	-9245.0	7715.0
Mri1	11542.0	-9317.0
Mtap	-4021.0	11510.0
Mtr	-5394.0	6108.0
Mtrr	-9808.0	11000.0
Naalad2	3839.0	4976.0
Nags	-5660.0	8285.0
Nat8l	-8332.0	7392.0
Ndufab1	3106.0	-9458.0
Nmral1	-9112.0	9716.0
Nnmt	11136.0	-12817.0
Nqo1	12766.0	-5072.0
Oat	14211.0	-14408.0
Oaz1	-1927.0	8207.0
Oaz2	-11175.0	7564.0
Oaz3	9257.0	-6443.0
Oca2	3944.0	1486.0
Odc1	-12658.0	12090.0
Ogdh	12207.0	-6438.0
Otc	-4507.0	-1222.5
Pah	-12167.0	12288.0
Paox	12712.0	-8841.0
Papss1	-8777.0	11499.0
Papss2	12971.0	-12114.0
Pcbd1	10683.0	-12253.0
Pdha1	10727.0	-14169.0
Pdhb	13003.0	-14216.0
Pdhx	2479.0	6526.0
Phgdh	11783.0	-3454.0
Phykpl	-6154.0	8990.0
Pipox	-11536.0	10316.0
Pnmt	876.5	-1222.5
Ppm1k	14643.0	-11680.0
Prodh	10521.0	7441.0
Prodh2	-3986.0	-7482.0
Psat1	11508.0	-13101.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Psph	13653.0	-12194.0
Pstk	-9537.0	9420.0
Pxmp2	10094.0	-13097.0
Pycr1	-4157.0	-4517.0
Pycr2	14050.0	-10135.0
Pycrl	-7439.0	-4811.0
Qdpr	12216.0	-7878.0
Rida	-4082.0	-14194.0
Rimkla	11540.0	3444.0
Rimklb	-9845.0	-4853.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Sardh	-11194.0	11048.0
Sat1	13951.0	-13619.0
Scly	-9905.0	9810.0
Sds	-1128.0	-3689.5
Sdsl	9976.0	-7013.0
Secisbp2	-9337.0	10086.0
Sephs2	-10506.0	11018.0
Sepsecs	-12324.0	11433.0
Serinc1	-10068.0	-12264.0
Serinc2	-11788.0	9012.0
Serinc3	13906.0	-14551.0
Serinc4	6462.0	-7859.0
Serinc5	13682.0	-12585.0
Shmt1	15258.0	-14887.0
Slc25a10	4794.0	-10546.0
Slc25a12	15159.0	-10019.0
Slc25a13	-8801.0	-10830.0
Slc25a15	-10444.0	11979.0
Slc25a2	-6038.0	8096.0
Slc25a21	-11336.0	8844.0
Slc25a44	13241.0	-13126.0
Slc36a4	13705.0	-12774.0
Slc3a2	12234.0	-4863.0
Slc44a1	-6813.0	1668.0
Slc45a2	10416.0	-10692.0
Slc5a5	8692.0	-4531.0
Slc6a11	1803.5	-2073.5
Slc6a12	15137.0	-15079.0
Slc6a7	10389.0	-11196.0
Slc7a5	14136.0	-14270.0
Smox	-9435.0	12233.0
Sms	-10656.0	7982.0
Sqrdl	6576.0	-8275.0
Srm	-3953.0	3596.0
Srr	-11776.0	11131.0
Suox	11989.0	-5545.0
Tat	6864.0	-12923.0
Tdo2	-4266.0	-6861.0
Th	876.5	-1222.5
Tmlhe	-10942.0	5100.0
Tph1	-1131.5	3286.0
Tph2	9628.0	-10386.0
Tpo	9823.0	-10576.0
Tst	-11064.0	9797.0
Tstd1	-10895.0	12049.0
Txn2	-2645.0	-7555.0
Txnrd1	-10298.0	11671.0
Tyrp1	7513.0	-8064.0
Uba52	4596.0	-6796.0
Uroc1	12757.0	-13430.0

---

---

Complex-I-biogenesis

Complex-I-biogenesis

metric	value
setSize	54
pMANOVA	7.15e-13
p.adjustMANOVA	3.12e-11
s.dist	0.757
s.diab	0.5
s.PMX	-0.568
p.diab	1.98e-10
p.PMX	5.21e-13

Top 20 genes

Gene	diab	PMX
Ndufa7	15178	-15058
Ndufb9	15350	-14839
Ndufa5	15074	-14984
Ndufv2	15041	-14992
Ndufa6	14999	-14781
Ndufa3	14864	-14832
Ndufb11	14492	-14964
Ndufa9	14469	-14794
Ndufb5	14481	-14745
Ndufs6	14367	-14846
Ndufa11	14920	-14266
Ndufa12	14903	-14234
Ndufb10	14262	-14459
Ndufs3	14315	-14178
Ndufa2	13627	-14858
Ndufc1	14230	-14172
Ndufa13	14115	-14226
Ndufs4	14110	-14049
Ndufs5	13994	-14136
Ndufs2	14590	-13546

Click HERE to show all gene set members

All member genes

	diab	PMX
Acad9	-11100	-9605
Ecsit	-9099	9725
mt-Nd1	13965	-13142
mt-Nd2	13232	-13777
mt-Nd3	5043	-3048
mt-Nd4	9342	-12167
mt-Nd5	13692	-13085
mt-Nd6	14568	-9103
Ndufa1	6937	-8412
Ndufa10	11110	-8885
Ndufa11	14920	-14266
Ndufa12	14903	-14234
Ndufa13	14115	-14226
Ndufa2	13627	-14858
Ndufa3	14864	-14832
Ndufa5	15074	-14984
Ndufa6	14999	-14781
Ndufa7	15178	-15058
Ndufa8	13665	-11997
Ndufa9	14469	-14794
Ndufab1	3106	-9458
Ndufaf1	-11416	10941
Ndufaf2	7440	-8823
Ndufaf3	367	-9795
Ndufaf4	-10599	6962
Ndufaf5	11575	-3621
Ndufaf6	333	-11082
Ndufaf7	9013	1113
Ndufb10	14262	-14459
Ndufb11	14492	-14964
Ndufb2	-4388	-8058
Ndufb3	12259	-14461
Ndufb4	9233	-12329
Ndufb5	14481	-14745
Ndufb6	14565	-13471
Ndufb7	13625	-13723
Ndufb9	15350	-14839
Ndufc1	14230	-14172
Ndufc2	13402	-13866
Ndufs1	7192	-12095
Ndufs2	14590	-13546
Ndufs3	14315	-14178
Ndufs4	14110	-14049
Ndufs5	13994	-14136
Ndufs6	14367	-14846
Ndufs7	11801	-14074
Ndufs8	12503	-14256
Ndufv1	7781	-368
Ndufv2	15041	-14992
Ndufv3	8348	4422
Nubpl	-8841	6873
Timmdc1	-7729	8038
Tmem126b	-11814	6995
Tmem186	-10081	10176

---

---

Metabolism

Metabolism

metric	value
setSize	1892
pMANOVA	1.65e-12
p.adjustMANOVA	6.98e-11
s.dist	0.131
s.diab	0.0909
s.PMX	-0.0946
p.diab	3.66e-11
p.PMX	5.66e-12

Top 20 genes

Gene	diab	PMX
Nnt	15395	-15153
Aldh1a1	15391	-15151
Aldoc	15389	-15147
Pdxk	15382	-15130
Ugt1a2	15365	-15146
Glud1	15380	-15127
Bbox1	15339	-15141
Gpc1	15341	-15137
Acsf2	15381	-15095
Kynu	15385	-15087
Mdh1	15344	-15111
Maob	15343	-15106
Agt	15303	-15119
Elovl2	15359	-15062
Gstm5	15299	-15104
Mgst3	15295	-15082
Ugt1a1	15247	-15108
Gc	15290	-15020
Mogat2	15338	-14969
Asrgl1	15370	-14930

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Aacs	-12194.0	-8634.0
Aadac	-10442.0	2939.0
Aadat	-11810.0	8847.0
Aanat	-2109.5	2317.5
Aasdhppt	-8649.0	7328.0
Aass	-11261.0	6694.0
Abca1	13450.0	-12955.0
Abcb11	-5857.0	-4835.0
Abcb1a	-11333.0	10692.0
Abcb4	-2352.0	-7194.0
Abcb7	-6221.0	-11664.0
Abcc2	11196.0	-3540.0
Abcc3	15114.0	-14788.0
Abcc5	6103.0	7523.0
Abcc8	-2559.0	-4786.0
Abcd1	-8201.0	4179.0
Abcd4	15023.0	-12529.0
Abcg3	-10478.0	10531.0
Abhd10	-6166.0	11325.0
Abhd14b	-12394.0	12477.0
Abhd3	-11799.0	5131.0
Abhd4	14834.0	-2414.0
Abhd5	-7920.0	11735.0
Abo	5395.0	-5584.5
AC149090.1	-9700.0	11545.0
Acaa1b	-10163.0	-5478.0
Acaa2	13787.0	-12686.0
Acaca	-9725.0	9391.0
Acacb	15271.0	-13361.0
Acad11	11992.0	-13024.0
Acad12	-12271.0	11302.0
Acad8	-8463.0	10460.0
Acad9	-11100.0	-9605.0
Acadl	-7545.0	-14607.0
Acadm	-8540.0	-13297.0
Acads	-12148.0	11225.0
Acadsb	7755.0	-5921.0
Acadvl	8255.0	-13764.0
Acat1	-12750.0	12108.0
Acat2	14491.0	-13475.0
Acbd4	-11347.0	11661.0
Acbd5	-7869.0	6077.0
Acbd6	5558.0	7371.0
Acbd7	4416.0	-202.0
Acer2	15010.0	-14603.0
Acer3	-4134.0	-12352.0
Ache	14738.0	-13901.0
Acly	-11233.0	6972.0
Acmsd	-11000.0	11260.0
Aco2	15080.0	-14219.0
Acot11	7005.0	-12985.0
Acot12	-11783.0	-11148.0
Acot13	13946.0	-14526.0
Acot2	13639.0	-13644.0
Acot4	2339.0	-13537.0
Acot6	9707.0	-5966.0
Acot7	13883.0	-14766.0
Acot8	8482.0	-13111.0
Acot9	3881.0	-12798.0
Acox1	-11872.0	3317.0
Acox2	12733.0	-10656.0
Acox3	5333.0	-5710.0
Acoxl	-5080.0	6988.0
Acp5	-9419.0	8924.0
Acp6	11602.0	9174.0
Acsbg1	-77.0	12043.0
Acsf2	15381.0	-15095.0
Acsf3	-8808.0	8623.0
Acsl1	12055.0	-12975.0
Acsl3	9190.0	-14649.0
Acsl4	13636.0	-14602.0
Acsl5	15155.0	385.0
Acsl6	-1640.0	10719.0
Acsm1	-12420.0	12428.0
Acsm2	-12721.0	12837.0
Acsm3	-11790.0	11114.0
Acsm4	8497.0	-10415.0
Acsm5	9547.0	9315.0
Acss1	11036.0	5172.0
Acss2	-11678.0	10355.0
Acss3	2795.0	12677.0
Acy1	-9848.0	172.0
Acy3	-12314.0	11592.0
Ada	13471.0	-10331.0
Adal	-8219.0	10271.0
Adcy1	-9688.0	10111.0
Adcy2	10325.0	-11711.0
Adcy3	-9740.0	12419.0
Adcy4	-7538.0	10359.0
Adcy5	5265.0	12483.0
Adcy6	12805.0	-11480.0
Adcy7	-11420.0	12113.0
Adcy8	-5867.0	1557.0
Adcy9	-9790.0	11763.0
Adh1	-12595.0	12581.0
Adh4	164.0	-2228.0
Adh5	4957.0	-8680.0
Adh6a	5623.0	-3151.0
Adh7	337.0	-5161.0
Adhfe1	-12630.0	11500.0
Adi1	-8270.0	11019.0
Adipor1	9642.0	-5623.0
Adipor2	12001.0	-13171.0
Adk	-215.0	-14123.0
Ado	-3981.0	8706.0
Adpgk	-6332.0	3273.0
Adprm	12219.0	-13112.0
Adra2a	14051.0	-12657.0
Adra2c	366.0	11207.0
Adsl	2421.0	10159.0
Adss	12586.0	-14664.0
Adssl1	13952.0	-11924.0
Afmid	-12623.0	12121.0
Agk	-1563.0	6759.0
Agl	10386.0	7410.0
Agmat	-8595.0	11784.0
Agmo	-9713.0	2152.0
Agpat1	-4506.0	-6035.0
Agpat2	10553.0	-8152.0
Agpat3	-7384.0	-10929.0
Agpat4	-6273.0	3634.0
Agpat5	12152.0	-6450.0
Agpat9	15088.0	-14677.0
Agps	-12705.0	12544.0
Agrn	-2557.0	10075.0
Agt	15303.0	-15119.0
Agxt	2454.0	1966.0
Agxt2	-8255.0	-7637.0
Ahcy	-6297.0	-13572.0
Ahcyl1	6832.0	-14545.0
Ahr	-7584.0	6885.0
Ahrr	-4077.0	5674.0
Aimp1	10685.0	-10801.0
Aimp2	3346.0	9731.0
Aip	11563.0	-6862.0
Ak1	15173.0	-7487.0
AK157302	5753.0	-5932.0
Ak2	-4070.0	-12061.0
Ak4	-10996.0	-3393.0
Ak5	-9996.0	12778.0
Ak7	14809.0	-14990.0
Ak8	6705.0	-455.0
Ak9	-4119.0	4434.0
Akap5	13260.0	-8998.0
Akr1a1	-10311.0	12335.0
Akr1b3	-4805.0	-11510.0
Akr1b8	13737.0	-14489.0
Akr1c14	-11016.0	7849.0
Akr1d1	10456.0	9360.0
Akr7a5	-12373.0	12118.0
Akt1	11899.0	-4407.0
Alad	-10369.0	10115.0
Alas1	10841.0	-13047.0
Alas2	-11132.0	12253.0
Alb	-5186.0	-12238.0
Aldh18a1	12016.0	-9762.0
Aldh1a1	15391.0	-15151.0
Aldh1b1	15311.0	-13890.0
Aldh1l1	13510.0	-8971.0
Aldh1l2	13820.0	-6925.0
Aldh2	-8630.0	11396.0
Aldh3a1	12622.0	-7407.0
Aldh3a2	-12490.0	12401.0
Aldh3b1	13886.0	-14132.0
Aldh3b3	-12246.0	-11034.0
Aldh4a1	10650.0	-4474.0
Aldh6a1	-12214.0	11149.0
Aldh7a1	-7596.0	9943.0
Aldh9a1	4156.0	-8886.0
Aldoart2	-2897.5	617.5
Aldob	15112.0	-15035.0
Aldoc	15389.0	-15147.0
Alox12	8282.0	9204.0
Alox12b	5487.5	1605.0
Alox15	7967.0	-4738.0
Alox5	13133.0	-417.0
Alox5ap	-5308.0	1335.0
Alox8	12026.0	-9822.0
Aloxe3	12358.0	-7941.0
Amacr	-12668.0	12850.0
Amd1	-11782.0	9516.0
Amdhd1	13013.0	-9775.0
Amn	-9599.0	11264.0
Ampd1	4903.0	4042.0
Ampd2	-10194.0	10398.0
Ampd3	13298.0	-9018.0
Amt	14204.0	-9127.0
Angptl4	8449.0	-14576.0
Ankrd1	9799.0	-12771.0
Aoc1	13733.0	-14281.0
Aoc2	12177.0	-10156.0
Aoc3	8414.0	9167.0
Aox1	10545.0	-12839.0
Apip	10598.0	-8306.0
Apoa1	-4915.0	-14116.0
Apoa1bp	11968.0	-12844.0
Apoa2	14354.0	-14888.0
Apoa4	-1360.0	-13303.0
Apoa5	-1213.0	-11084.0
Apob	14399.0	-9778.0
Apoc3	14994.0	-14912.0
Apoe	14840.0	-14885.0
Apom	-11384.0	9260.0
Aprt	15212.0	-13633.0
Arf1	-4458.0	-3277.0
Arf3	-2671.0	7500.0
Arg1	-4401.0	-6657.5
Arg2	15043.0	-14789.0
Arnt	7604.0	-12300.0
Arnt2	15211.0	8798.0
Arntl	-3021.0	9713.0
Arsa	13969.0	-10374.0
Arsb	-11119.0	11194.0
Arsg	-10042.0	11023.0
Arsi	-10929.0	11893.0
Arsj	5613.0	3954.0
Arsk	-10972.0	8083.0
Arv1	-4059.0	3009.0
As3mt	-1664.0	-11167.0
Asah1	11930.0	-14375.0
Asah2	-10708.0	-8079.0
Asmt	-1605.0	4934.0
Asns	14974.0	-13140.0
Aspa	3473.0	-10542.0
Aspg	-9514.0	-4363.0
Asrgl1	15370.0	-14930.0
Ass1	-12485.0	12875.0
Atic	-8523.0	8225.0
Auh	-3107.0	2097.0
Awat2	-4981.0	-4494.0
Azin1	-9195.0	-11121.0
Azin2	13002.0	-8938.0
B3galnt1	11241.0	2479.0
B3galt1	12764.0	3376.0
B3galt2	-11127.0	9954.0
B3galt4	-5590.0	10826.0
B3galt5	-12108.0	10014.0
B3galt6	-11180.0	10373.0
B3gat1	1803.5	10280.0
B3gat2	-12537.0	12143.0
B3gat3	-9154.0	11056.0
B3gnt2	8187.0	-7255.0
B3gnt3	-8516.0	7824.0
B3gnt4	4055.0	-2791.5
B3gnt7	9793.0	4595.0
B4galnt1	14943.0	-13768.0
B4galnt2	10369.0	-12357.0
B4galt1	11485.0	-14015.0
B4galt2	-5830.0	8955.0
B4galt3	11819.0	-12143.0
B4galt4	8397.0	-4662.0
B4galt5	-12781.0	13022.0
B4galt6	14144.0	-13515.0
B4galt7	-3850.0	3351.0
B4gat1	-4815.0	4517.0
Baat	13687.0	-14064.0
Bbox1	15339.0	-15141.0
Bcan	1803.5	-1222.5
Bcat1	-8105.0	-9482.0
Bcat2	10628.0	1717.0
Bche	13959.0	-13959.0
Bckdha	-10102.0	11338.0
Bckdhb	-5600.0	-2924.0
Bckdk	-9640.0	9834.0
Bco1	14381.0	-13044.0
Bco2	-11362.0	11605.0
Bdh1	-12056.0	10918.0
Bdh2	-7090.0	-10090.0
Bgn	-2592.0	8406.0
Bhmt	15373.0	-14717.0
Bhmt2	13948.0	-13849.0
Blvra	14254.0	-15053.0
Blvrb	-9559.0	9965.0
Bmx	-2611.0	8210.0
Bpgm	-9532.0	7429.0
Bphl	-12704.0	9105.0
Bpnt1	-4307.0	325.0
Brip1	12955.0	-13168.0
Bsg	10831.0	-9772.0
Bst1	14676.0	-14687.0
Btd	7900.0	-12093.0
Bzrap1	12576.0	-6510.0
Cacna1a	3165.0	8312.0
Cacna1c	-9529.0	10981.0
Cacna1d	13918.0	-13958.0
Cacna1e	14686.0	-2514.0
Cacna2d2	-2938.0	9245.0
Cacnb2	13987.0	-13437.0
Cacnb3	14958.0	-9946.0
Cad	-8648.0	12396.0
Calm1	152.0	-11443.0
Car1	-3167.5	2317.5
Car12	7148.0	11937.0
Car13	12194.0	-13023.0
Car14	15057.0	-14175.0
Car2	15260.0	-14732.0
Car3	-12664.0	12315.0
Car4	-12743.0	11263.0
Car5a	13974.0	-14692.0
Car5b	13913.0	-14829.0
Car6	-2507.5	457.0
Car7	-3061.0	10834.0
Car9	-10836.0	5039.0
Carm1	8621.0	-6979.0
Carnmt1	10294.0	-12262.0
Carns1	6176.0	1103.0
Cav1	-3675.0	10920.0
Cbr1	15298.0	-14738.0
Cbr3	14959.0	-11304.0
Cbr4	12595.0	-12015.0
Cbs	-12747.0	12807.0
Ccnc	-5644.0	1167.0
Cd320	6699.0	-9124.0
Cd36	-11769.0	10112.0
Cd38	351.0	10985.0
Cd44	-11921.0	11492.0
Cda	-10384.0	160.0
Cdipt	9620.0	-3453.0
Cdk19	105.0	9597.0
Cdk8	13548.0	-13286.0
Cdo1	14140.0	-14368.0
Cds1	15164.0	-13001.0
Cds2	6876.0	3707.0
Cemip	14909.0	249.0
Cept1	11589.0	-14060.0
Cerk	13637.0	4098.0
Cers1	-3964.0	-4357.0
Cers2	-260.0	-5127.0
Cers3	10976.0	-11208.0
Cers4	13287.0	-12432.0
Cers5	-11139.0	-3457.0
Cers6	-1077.0	-14735.0
Ces1a	10997.0	-7667.0
Ces3a	-8795.0	5335.0
Ch25h	-2670.0	-2929.0
Chac1	9497.0	-11449.0
Chac2	-10181.0	-6190.0
Chd9	-8520.0	9935.0
Chdh	-12368.0	7161.0
Chka	10827.0	-6725.0
Chkb	15237.0	-14512.0
Chp1	14200.0	-15109.0
Chpf	12255.0	-8758.0
Chpf2	-9321.0	9428.0
Chpt1	-11996.0	8548.0
Chrm3	-3741.0	10213.0
Chst1	-6656.0	11612.0
Chst11	-12079.0	12179.0
Chst12	-5177.0	8544.0
Chst13	7966.0	-7952.0
Chst14	-7856.0	10231.0
Chst15	5181.0	6791.0
Chst2	-7941.0	10900.0
Chst3	-7254.0	-12342.0
Chst7	-11730.0	8026.0
Chst9	4267.0	-12683.0
Chsy1	10583.0	-11544.0
Chsy3	8574.0	-6277.0
Ciao1	4495.0	3314.0
Ciapin1	4532.0	7932.0
Cidea	3449.0	-5247.0
Cidec	10906.0	-12016.0
Ckb	14356.0	-5744.0
Ckm	-4939.0	-5464.0
Ckmt1	15310.0	5970.0
Ckmt2	-4824.0	1414.0
Clock	13462.0	-8810.0
Cmbl	-11516.0	10583.0
Cmpk1	13861.0	-14235.0
Cndp2	-12749.0	12941.0
Coasy	-12670.0	12410.0
Comt	12591.0	5841.0
Coq10a	6677.0	7304.0
Coq10b	-10247.0	-10904.0
Coq2	-2284.0	1201.0
Coq3	-10597.0	8630.0
Coq5	-5796.0	9365.0
Coq6	2939.0	4726.0
Coq7	14217.0	-12873.0
Coq9	-5555.0	7632.0
Cox10	5667.0	6898.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox15	-12085.0	12512.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Cpne1	-9213.0	8279.0
Cpne3	11141.0	-7975.0
Cpne6	-926.0	3274.5
Cpne7	-4140.0	8445.0
Cpox	-12578.0	12696.0
Cps1	-2822.0	-13202.0
Cpt1a	-5709.0	-5838.0
Cpt1b	10610.0	-6049.0
Cpt2	-7877.0	-6448.0
Cptp	-5776.0	5259.0
Crat	8867.0	-9382.0
Crebbp	7115.0	-7498.0
Crls1	12694.0	-13167.0
Crot	-10651.0	-6674.0
Cryl1	13765.0	-8752.0
Crym	14306.0	-14651.0
Cs	14592.0	-10223.0
Csad	-12263.0	10862.0
Csgalnact1	-12644.0	12994.0
Csgalnact2	-6475.0	6235.0
Csnk1g2	-1756.0	8547.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Cspg4	14584.0	-12694.0
Cspg5	6829.0	6703.0
Cth	13940.0	-15012.0
Ctps	-8218.0	-7116.0
Ctps2	-3901.0	-13434.0
Ctrb1	-485.5	-1222.5
Ctsa	10725.0	5642.0
Cubn	12176.0	-12708.0
Cyb5a	-12655.0	12321.0
Cyb5b	-2313.0	2883.0
Cyb5r3	-8914.0	10571.0
Cyc1	13836.0	-13962.0
Cycs	8402.0	-13138.0
Cygb	-7743.0	10602.0
Cyp11a1	2647.0	-4180.0
Cyp11b1	876.5	-1222.5
Cyp17a1	14163.0	-14460.0
Cyp1a1	5016.0	-6776.0
Cyp1a2	-5793.0	-3689.5
Cyp1b1	-6633.0	8890.0
Cyp21a1	-5938.5	2317.5
Cyp24a1	-10020.0	10365.0
Cyp26a1	-10322.0	6755.0
Cyp26b1	10731.0	-10315.0
Cyp26c1	-9327.0	9040.0
Cyp27a1	14863.0	-13160.0
Cyp27b1	14539.0	-12581.0
Cyp2a4	-12283.0	11309.0
Cyp2b10	-10408.0	-10499.0
Cyp2c55	10230.0	-8616.0
Cyp2d34	4974.0	-12673.0
Cyp2e1	-12421.0	12042.0
Cyp2f2	7133.0	9928.0
Cyp2j13	-12339.0	12471.0
Cyp2r1	7142.0	-12598.0
Cyp2s1	14245.0	5353.0
Cyp2u1	10956.0	12712.0
Cyp39a1	15106.0	-14699.0
Cyp3a13	8316.0	-6415.0
Cyp46a1	12074.0	-9882.0
Cyp4b1	-12542.0	12238.0
Cyp4f15	-11227.0	9970.0
Cyp4f39	7.0	-5933.0
Cyp4v3	14236.0	-6497.0
Cyp51	11509.0	-15089.0
Cyp7a1	876.5	-1222.5
Cyp7b1	-8810.0	-6218.0
Cyp8b1	-4772.5	2317.5
Cysltr2	-9641.0	10418.0
D2hgdh	-12310.0	8579.0
Dao	-11927.0	12533.0
Dbh	-2109.5	2317.5
Dbi	14125.0	-15033.0
Dbt	-11658.0	9290.0
Dck	3316.0	2588.0
Dcn	-9149.0	12256.0
Dct	2483.5	1359.0
Dctd	-8754.0	1187.0
Dctpp1	9440.0	264.0
Dcxr	-3143.0	8447.0
Ddah1	-10748.0	-9190.0
Ddah2	9619.0	-3627.0
Ddc	15208.0	-7341.0
Ddhd1	6473.0	-11404.0
Ddhd2	14112.0	-14295.0
Ddo	-12459.0	12340.0
Decr1	7805.0	-13641.0
Decr2	13444.0	-13621.0
Degs1	-9302.0	6785.0
Degs2	-12768.0	12978.0
Dera	13448.0	-5022.0
Dgat1	7111.0	-8319.0
Dgat2	-9438.0	5745.0
Dgat2l6	876.5	-1222.5
Dguok	3687.0	4039.0
Dhcr24	-8792.0	10363.0
Dhcr7	253.0	9522.0
Dhfr	-11741.0	10911.0
Dhodh	12170.0	-3773.0
Dhrs7b	-5570.0	2516.0
Dhtkd1	-11638.0	11406.0
Dio1	355.0	-12703.0
Dio2	-7785.0	1452.0
Dio3	-805.0	-8677.0
Dlat	11467.0	-7817.0
Dld	5477.0	-13041.0
Dlst	10927.0	-8985.0
Dmgdh	12087.0	-12209.0
Dnm2	11590.0	-11213.0
Dnph1	-12331.0	12734.0
Dpep1	-1361.0	7475.0
Dpep2	10300.0	-9549.0
Dpep3	8902.0	-8612.0
Dpyd	9949.0	-13870.0
Dpys	-12754.0	12952.0
Dse	-10715.0	11519.0
Dsel	-366.0	6901.0
Dtymk	-6853.0	10622.0
Duox1	-6850.0	12109.0
Duox2	-6484.0	1308.0
Dut	-8067.0	8288.0
Ebp	14078.0	-15116.0
Echs1	-1268.0	-11574.0
Eci1	14682.0	-15054.0
Eci3	-8415.0	-9767.0
Ecsit	-9099.0	9725.0
Eefsec	-7997.0	11830.0
Ehhadh	-11234.0	-3390.0
Elovl1	5839.0	1770.0
Elovl2	15359.0	-15062.0
Elovl4	130.0	-6750.0
Elovl5	11216.0	-12728.0
Elovl6	15130.0	-15040.0
Elovl7	10848.0	-13738.0
Eno1	15346.0	-14918.0
Eno2	11792.0	-13834.0
Eno3	12251.0	-12638.0
Enoph1	9436.0	3697.0
Enpp1	-9548.0	9710.0
Enpp2	13793.0	-14844.0
Enpp3	-6704.0	-13956.0
Enpp6	12365.0	-11526.0
Entpd1	15235.0	-14142.0
Entpd2	10919.0	-11631.0
Entpd3	8371.0	-3777.0
Entpd5	-3477.0	-2420.0
Entpd6	8001.0	11343.0
Entpd7	-12541.0	11586.0
Entpd8	6609.0	5834.0
Ep300	-10091.0	9600.0
Ephx1	15392.0	-14869.0
Ephx2	-12329.0	11684.0
Epm2a	-6367.0	10786.0
Ercc2	-4287.0	6769.0
Esd	14562.0	-14937.0
Esrra	-4191.0	12180.0
Esyt1	12792.0	-11772.0
Esyt2	-292.0	-11735.0
Esyt3	10355.0	-10448.0
Etfa	-9804.0	-7984.0
Etfb	11075.0	-11149.0
Etfdh	-1913.0	-8426.0
Ethe1	-8843.0	12367.0
Etnk1	15231.0	-14942.0
Etnk2	9476.0	-14783.0
Etnppl	14345.0	-14400.0
Ext1	12331.0	-13156.0
Ext2	12691.0	188.0
Fa2h	14637.0	-14644.0
Faah	218.0	-3231.0
Fabp1	13947.0	-14420.0
Fabp12	-2468.0	4722.0
Fabp3	14687.0	-12488.0
Fabp4	9930.0	-14341.0
Fabp5	8166.0	-13050.0
Fabp6	6126.5	-5441.0
Fabp7	8230.0	9801.0
Fabp9	4015.5	1403.5
Fads1	12123.0	-12779.0
Fads2	-12080.0	-2326.0
Fah	-11378.0	6288.0
Fahd1	-11442.0	10570.0
Fam120b	-12154.0	10639.0
Far1	-12256.0	4953.0
Far2	4195.5	-2715.5
Fasn	-9125.0	-6865.0
Fbp1	14971.0	-13560.0
Fbp2	15221.0	-14331.0
Fdft1	15301.0	-14822.0
Fdx1	-8275.0	-8144.0
Fdx1l	6733.0	5275.0
Fdxr	8464.0	5073.0
Fech	-9686.0	4336.0
Ffar1	4661.0	-7356.0
Fh1	14053.0	-14546.0
Fhl2	-10902.0	10435.0
Fig4	7116.0	8283.0
Fitm1	14004.0	-14751.0
Fitm2	11879.0	-14221.0
Flad1	-11499.0	11891.0
Flt3l	-10231.0	11283.0
Fmo1	-11942.0	6227.0
Fmo2	-10951.0	4068.0
Fmo3	11087.0	-6868.0
Fmod	-8347.0	7370.0
Folh1	15352.0	-14926.0
Fpgs	-9651.0	5707.0
Ftcd	11369.0	10881.0
Fut1	-5603.0	8324.0
Fut10	2451.0	37.0
Fut11	-10413.0	7884.0
Fut2	11389.0	-4686.0
Fut4	-7896.0	10996.0
Fut7	262.0	6678.0
Fut9	-12547.0	11885.0
Fxn	-5738.0	-7931.0
G0s2	-6415.0	-4936.0
G6pc2	6368.0	-5830.0
G6pc3	-3265.0	-265.0
Gaa	-6574.0	8913.0
Gadl1	-892.5	3221.5
Galc	-6581.0	5512.0
Gale	13112.0	-12036.0
Galk1	7350.0	-5365.0
Galt	9830.0	8462.0
Gamt	-12204.0	10782.0
Gart	-11116.0	11365.0
Gatm	14388.0	-10805.0
Gba	-7933.0	-9867.0
Gba2	-7402.0	11899.0
Gbe1	11518.0	-10709.0
Gc	15290.0	-15020.0
Gcat	-3834.0	8853.0
Gcdh	-9906.0	4382.0
Gch1	9584.0	-10757.0
Gchfr	-10629.0	-6768.0
Gck	-7462.0	1439.0
Gckr	6483.0	-11394.0
Gclc	-11800.0	2957.0
Gclm	-12094.0	10473.0
Gcsh	15232.0	-14871.0
Gda	-12539.0	-9104.0
Gde1	14696.0	-13441.0
Gdpd1	13496.0	-6959.0
Gdpd3	9303.0	-14764.0
Gdpd5	15342.0	-14410.0
Ggct	-12137.0	11245.0
Ggps1	5379.0	-8691.0
Ggt1	-12560.0	11739.0
Ggt5	4333.0	8563.0
Ggt6	-7124.0	8933.0
Ggt7	-1391.0	5341.0
Gk	-10566.0	-8277.0
Gla	9515.0	3656.0
Glb1	-8411.0	-6920.0
Glb1l	-12255.0	12476.0
Glce	4771.0	-5889.0
Gldc	14602.0	-14681.0
Glipr1	-9835.0	7579.0
Glo1	-6526.0	-5471.0
Glp1r	241.0	9485.0
Glrx	14995.0	-14279.0
Glrx5	13294.0	-5561.0
Gls	13744.0	-14134.0
Gls2	5942.0	60.0
Gltp	14020.0	-13692.0
Glud1	15380.0	-15127.0
Glul	14333.0	-14998.0
Glyat	-11906.0	10265.0
Glyatl3	3735.0	-3929.0
Glyctk	-12765.0	12981.0
Gm10263	6260.5	-6620.0
Gm11273	8317.0	-6691.0
Gm2a	15199.0	-13398.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gmpr	-5815.0	7427.0
Gmpr2	-5459.0	-4690.0
Gmps	-3341.0	-6208.0
Gna11	13209.0	-163.0
Gna14	-11102.0	12283.0
Gna15	-10426.0	9120.0
Gnai1	-3956.0	-10186.0
Gnai2	11179.0	-2885.0
Gnaq	4627.0	-7966.0
Gnas	-3961.0	-3188.0
Gnb1	14052.0	-12910.0
Gnb2	8485.0	9301.0
Gnb3	-2490.5	742.0
Gnb4	-1201.0	-6056.0
Gnb5	13333.0	-11130.0
Gng10	2409.0	6218.0
Gng11	-3886.0	7951.0
Gng12	6244.0	-14594.0
Gng2	10797.0	-7497.0
Gng3	-4926.0	7095.0
Gng4	7213.0	10712.0
Gng5	4656.0	-12487.0
Gng7	-3080.0	9870.0
Gng8	-4369.0	8851.0
Gngt1	1803.5	-1222.5
Gngt2	-1659.0	-5045.0
Gnmt	-4555.0	5322.0
Gnpat	-11934.0	12268.0
Gnpda1	-12028.0	12899.0
Gnpda2	-8562.0	6913.0
Gns	14867.0	-12868.0
Got1	15126.0	-14433.0
Got2	14120.0	-12201.0
Gpam	11785.0	-8926.0
Gpat2	6112.0	5415.0
Gpat4	-5814.0	9782.0
Gpc1	15341.0	-15137.0
Gpc3	5652.0	10299.0
Gpc4	-12372.0	11165.0
Gpc5	-8809.0	3626.0
Gpc6	251.0	6933.0
Gpcpd1	-9822.0	3393.0
Gpd1	13472.0	-13095.0
Gpd1l	14271.0	-11379.0
Gpd2	-1350.0	-3552.0
Gphn	-9360.0	5310.0
Gpi1	14553.0	-14068.0
Gpihbp1	-10437.0	11549.0
Gps2	-1843.0	4625.0
Gpt	12659.0	3526.0
Gpt2	15224.0	-14057.0
Gpx1	-3900.0	5605.0
Gpx4	14699.0	-13801.0
Grhl1	13727.0	-7441.0
Grhpr	-10339.0	11416.0
Gsr	3160.0	8021.0
Gss	-7726.0	-492.0
Gsta1	14934.0	-14476.0
Gstk1	2673.0	-8811.0
Gstm2	12663.0	-9486.0
Gstm4	-6362.0	7481.0
Gstm5	15299.0	-15104.0
Gstm7	13245.0	-13556.0
Gsto1	15337.0	-14693.0
Gsto2	12936.0	-5831.0
Gstp1	-8797.0	11786.0
Gstt2	10089.0	-7713.0
Gstz1	-11792.0	8690.0
Guk1	14510.0	-14384.0
Gusb	-12493.0	12446.0
Gyg	-6365.0	-4546.0
Gys1	13439.0	-8942.0
Gys2	-12270.0	12492.0
H2-Ke6	-4046.0	1974.0
Haao	-11862.0	4642.0
Hacd1	6932.0	-12181.0
Hacd2	-12461.0	4212.0
Hacd3	-9211.0	-5659.0
Hacd4	12014.0	-13282.0
Hacl1	15223.0	-14820.0
Hadh	-9518.0	3733.0
Hadha	15039.0	-14946.0
Hadhb	14610.0	-14892.0
Hagh	13540.0	-13830.0
Hal	-3038.0	-7759.0
Hao1	7741.0	-11214.0
Hao2	13233.0	-13799.0
Has2	876.5	596.0
Has3	-2311.0	-6712.0
Hdac3	12487.0	-6122.0
Hdc	12931.0	-12335.0
Helz2	6489.0	-6856.0
Hexa	14928.0	-11069.0
Hexb	-12436.0	12157.0
Hgd	-2873.0	-6675.0
Hibadh	-12251.0	5564.0
Hibch	-5381.0	-10917.0
Hilpda	10999.0	-8552.0
Hk1	14801.0	-13674.0
Hk2	-9820.0	12243.0
Hk3	-8413.0	8008.0
Hlcs	14027.0	-204.0
Hmbs	6020.0	5541.0
Hmgcl	-4147.0	-3762.0
Hmgcll1	3474.0	32.0
Hmgcr	-11695.0	-12651.0
Hmgcs1	-11022.0	-9704.0
Hmgcs2	12198.0	-14691.0
Hmmr	13358.0	-11832.0
Hmox1	-10213.0	8284.0
Hmox2	-1185.0	6463.0
Hnmt	-6205.0	-4283.0
Hoga1	-3854.0	6390.0
Hpd	10836.0	-13526.0
Hpgd	-10141.0	9859.0
Hpgds	12386.0	-14125.0
Hprt	-263.0	-6922.0
Hpse	323.0	4852.0
Hpse2	-2919.0	10037.0
Hs2st1	10246.0	7517.0
Hs3st1	9740.0	-10188.0
Hs3st3b1	21.0	8678.0
Hs3st4	3175.0	-3250.0
Hs3st5	1803.5	6443.0
Hs3st6	12117.0	5101.0
Hs6st1	13115.0	-12843.0
Hs6st2	-9402.0	6561.0
Hs6st3	8172.0	2856.0
Hscb	13590.0	-9388.0
Hsd11b1	-12289.0	9417.0
Hsd11b2	13425.0	4227.0
Hsd17b1	-6559.0	4255.0
Hsd17b10	13714.0	-13444.0
Hsd17b11	-12691.0	12418.0
Hsd17b12	-4755.0	-13110.0
Hsd17b13	-4564.0	3905.0
Hsd17b14	13980.0	-14807.0
Hsd17b2	-10719.0	1084.0
Hsd17b3	876.5	820.5
Hsd17b4	13899.0	-14744.0
Hsd17b7	11115.0	-13438.0
Hsd3b7	-6485.0	-6163.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Hspg2	-9709.0	12765.0
Hyal1	-4256.0	-7947.0
Hyal2	-12152.0	11257.0
Hyal3	-1713.0	3650.0
Hykk	-12766.0	12868.0
Idh1	12702.0	-2443.0
Idh2	4708.0	-8898.0
Idh3a	12635.0	-11295.0
Idh3b	11502.0	-11793.0
Idh3g	4738.0	-13228.0
Idi1	-11671.0	12193.0
Ido1	9671.0	5429.0
Ido2	-9840.0	4.0
Ids	-10802.0	8409.0
Idua	12970.0	-12164.0
Il4i1	-9293.0	10683.0
Impa1	-8568.0	7789.0
Impa2	14077.0	7268.0
Impdh1	9836.0	9292.0
Impdh2	-4213.0	7223.0
Inmt	-12551.0	12151.0
Inpp1	-7654.0	12115.0
Inpp4a	-1544.0	2639.0
Inpp4b	5436.0	8906.0
Inpp5a	15192.0	-14296.0
Inpp5b	-4559.0	-7573.0
Inpp5d	42.0	6163.0
Inpp5e	4120.0	6851.0
Inpp5f	-6046.0	-7342.0
Inpp5j	-7837.0	9739.0
Inpp5k	14537.0	-13233.0
Inppl1	-4353.0	9146.0
Ins2	3527.5	4487.0
Insig1	15174.0	-14947.0
Insig2	9016.0	-8507.0
Ip6k1	12124.0	-12136.0
Ip6k2	15069.0	-14943.0
Ip6k3	2831.0	-2217.0
Ipmk	7516.0	-12940.0
Ippk	-3479.0	-220.0
Iqgap1	14527.0	-10145.0
Isca2	6859.0	-3775.0
Iscu	13440.0	-13647.0
Isyna1	14710.0	-10421.0
Itpa	7710.0	-9809.0
Itpk1	-12456.0	11680.0
Itpka	11797.0	-9371.0
Itpkb	-9247.0	12699.0
Itpkc	-1559.0	8407.0
Itpr1	10796.0	-11700.0
Itpr2	13551.0	7710.0
Itpr3	11003.0	2102.0
Ivd	-12660.0	12018.0
Iyd	11391.0	-10347.0
Kcnb1	14824.0	-13638.0
Kcnc2	12071.0	-15002.0
Kcng2	-4691.0	10671.0
Kcnj11	-406.0	8525.0
Kcns3	10689.0	-6045.0
Kdsr	-10207.0	6891.0
Khk	8908.0	-12865.0
Kmo	-10653.0	8379.0
Kpnb1	10908.0	1199.0
Kynu	15385.0	-15087.0
L2hgdh	-11075.0	10714.0
Lalba	1803.5	-1222.5
Lbr	-12455.0	12869.0
Lclat1	12474.0	-14666.0
Ldha	-5817.0	-9456.0
Ldhal6b	-4601.0	344.0
Ldhb	13267.0	4503.0
Ldlr	10618.0	-7930.0
Lgmn	14057.0	-13255.0
Lhb	1803.5	3096.0
Lhpp	14350.0	-13382.0
Lias	3695.0	-8546.0
Lipe	-9299.0	-144.0
Liph	13445.0	-11538.0
Lipi	-652.0	-1222.5
Lipt1	-11689.0	11665.0
Lipt2	-10418.0	8002.0
Lmbrd1	13592.0	-14574.0
Lpcat1	-4676.0	9938.0
Lpcat2	-10658.0	9903.0
Lpcat3	-3933.0	-14354.0
Lpcat4	14470.0	-6148.0
Lpgat1	-12254.0	9287.0
Lpin1	13638.0	-14073.0
Lpin2	12674.0	-14612.0
Lpin3	14358.0	-8350.0
Lpl	-12663.0	12811.0
Lrat	7330.0	-7181.0
Lrp1	-8511.0	11905.0
Lrp10	-5568.0	9106.0
Lrp12	-8864.0	-3415.0
Lrp2	-12753.0	12616.0
Lrp8	5634.0	-13285.0
Lrpprc	12946.0	-11138.0
Lss	14138.0	-13225.0
Lta4h	-5111.0	11279.0
Ltc4s	15281.0	2503.0
Lum	-2412.0	11141.0
Lypla1	-12034.0	8152.0
Lyrm4	6361.0	6379.0
Lyve1	8589.0	-4575.0
Man2b1	-9760.0	11502.0
Man2b2	12147.0	9412.0
Man2c1	8413.0	-463.0
Manba	-6746.0	8768.0
Maoa	15138.0	-15120.0
Maob	15343.0	-15106.0
Mapkapk2	14192.0	-11215.0
Marcks	-12211.0	12959.0
Mat1a	4223.0	-12815.0
Mat2a	-12403.0	9274.0
Mat2b	9472.0	4480.0
Mboat1	13786.0	3325.0
Mboat2	12859.0	-10746.0
Mboat7	-9652.0	-5756.0
Mbtps1	-10920.0	7056.0
Mbtps2	-4990.0	8254.0
Mcat	-5731.0	10358.0
Mccc1	-11486.0	11934.0
Mccc2	-8722.0	-8808.0
Mcee	12650.0	-13855.0
Mdh1	15344.0	-15111.0
Mdh2	14022.0	-13258.0
Me1	-12638.0	12081.0
Me2	13676.0	5847.0
Me3	10234.0	-4629.0
Mecr	-9496.0	11249.0
Med1	-11441.0	8371.0
Med10	10478.0	-7177.0
Med11	84.0	-4851.0
Med12	11266.0	-9802.0
Med13	-10911.0	4095.0
Med13l	9805.0	-12618.0
Med14	-12180.0	10557.0
Med15	9958.0	-10437.0
Med16	10702.0	9758.0
Med17	-4889.0	3919.0
Med18	4673.0	-13634.0
Med19	-2388.0	4318.0
Med20	3307.0	-12395.0
Med21	-10242.0	-4997.0
Med22	-5943.0	10518.0
Med23	-8528.0	10103.0
Med24	9179.0	2637.0
Med25	3394.0	7841.0
Med26	-5353.0	-5621.0
Med27	-4252.0	10386.0
Med28	-8723.0	-5517.0
Med29	-1528.0	2127.0
Med30	13189.0	-12925.0
Med31	-1583.0	-9965.0
Med4	12550.0	-13725.0
Med6	9448.0	-10889.0
Med7	-3242.0	-367.0
Med8	-7708.0	10963.0
Med9	11531.0	-8713.0
Mfsd2a	-6671.0	-14836.0
Mfsd7b	13756.0	-14707.0
Mgll	14365.0	-13681.0
Mgst1	15360.0	-14841.0
Mgst2	7160.0	2475.0
Mgst3	15295.0	-15082.0
Mid1ip1	6762.0	-11558.0
Minpp1	9905.0	7589.0
Miox	-11929.0	7804.0
Mlx	-9719.0	9866.0
Mlxipl	-12380.0	11517.0
Mlycd	-11672.0	10062.0
Mmaa	-12295.0	10027.0
Mmab	11417.0	-8200.0
Mmachc	-7956.0	10859.0
Mmadhc	4460.0	-12933.0
Mms19	13248.0	-10286.0
Mocos	9582.0	3552.0
Mocs1	8764.0	297.0
Mocs2	12289.0	-9323.0
Mocs3	-5851.0	9425.0
Mogat1	-12157.0	5448.0
Mogat2	15338.0	-14969.0
Morc2a	4635.0	2128.0
Mpc1	-8891.0	-4807.0
Mpc2	9933.0	-14059.0
Mpst	-9245.0	7715.0
Mri1	11542.0	-9317.0
Msmo1	14049.0	-12182.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Mtap	-4021.0	11510.0
Mtf1	-10197.0	7759.0
Mthfd1	9766.0	10459.0
Mthfd1l	14364.0	-14816.0
Mthfd2	14311.0	-11699.0
Mthfd2l	3452.0	2827.0
Mthfr	-9885.0	12688.0
Mthfsl	3252.0	3291.0
Mtm1	6625.0	-11917.0
Mtmr1	10716.0	-12146.0
Mtmr10	-10744.0	1680.0
Mtmr12	-12026.0	8146.0
Mtmr14	10965.0	-11015.0
Mtmr2	8297.0	-8703.0
Mtmr3	10733.0	-3451.0
Mtmr4	-10451.0	11634.0
Mtmr6	-3857.0	-11405.0
Mtmr7	-2604.0	6272.0
Mtmr9	12920.0	8361.0
Mtr	-5394.0	6108.0
Mtrr	-9808.0	11000.0
Mvd	-4895.0	-224.0
Mvk	14105.0	-12890.0
N6amt1	-5072.0	10569.0
Naalad2	3839.0	4976.0
Nadk	-10979.0	-7645.0
Nadk2	2946.0	134.0
Nadsyn1	-10321.0	11362.0
Naglu	-12533.0	12838.0
Nags	-5660.0	8285.0
Nampt	14825.0	-15052.0
Naprt	82.0	1106.0
Nat1	-10630.0	5056.0
Nat3	3527.5	1274.0
Nat8l	-8332.0	7392.0
Ncoa1	4134.0	10315.0
Ncoa2	-8492.0	10090.0
Ncoa3	-12300.0	12890.0
Ncoa6	10834.0	-11817.0
Ncor1	-12619.0	12282.0
Ncor2	-9484.0	9908.0
Ndc1	13238.0	-12109.0
Ndor1	11253.0	-6022.0
Ndst1	8759.0	8849.0
Ndst2	9014.0	-11316.0
Ndst3	-5907.0	3350.0
Ndst4	3715.0	-4650.0
Ndufa1	6937.0	-8412.0
Ndufa10	11110.0	-8885.0
Ndufa11	14920.0	-14266.0
Ndufa12	14903.0	-14234.0
Ndufa13	14115.0	-14226.0
Ndufa2	13627.0	-14858.0
Ndufa3	14864.0	-14832.0
Ndufa4	9874.0	-14669.0
Ndufa5	15074.0	-14984.0
Ndufa6	14999.0	-14781.0
Ndufa7	15178.0	-15058.0
Ndufa8	13665.0	-11997.0
Ndufa9	14469.0	-14794.0
Ndufab1	3106.0	-9458.0
Ndufaf1	-11416.0	10941.0
Ndufaf2	7440.0	-8823.0
Ndufaf3	367.0	-9795.0
Ndufaf4	-10599.0	6962.0
Ndufaf5	11575.0	-3621.0
Ndufaf6	333.0	-11082.0
Ndufaf7	9013.0	1113.0
Ndufb10	14262.0	-14459.0
Ndufb11	14492.0	-14964.0
Ndufb2	-4388.0	-8058.0
Ndufb3	12259.0	-14461.0
Ndufb4	9233.0	-12329.0
Ndufb5	14481.0	-14745.0
Ndufb6	14565.0	-13471.0
Ndufb7	13625.0	-13723.0
Ndufb9	15350.0	-14839.0
Ndufc1	14230.0	-14172.0
Ndufc2	13402.0	-13866.0
Ndufs1	7192.0	-12095.0
Ndufs2	14590.0	-13546.0
Ndufs3	14315.0	-14178.0
Ndufs4	14110.0	-14049.0
Ndufs5	13994.0	-14136.0
Ndufs6	14367.0	-14846.0
Ndufs7	11801.0	-14074.0
Ndufs8	12503.0	-14256.0
Ndufv1	7781.0	-368.0
Ndufv2	15041.0	-14992.0
Ndufv3	8348.0	4422.0
Neu1	-11918.0	13007.0
Neu2	-10643.0	2527.0
Neu3	10561.0	648.0
Neu4	3944.0	-4106.0
Nfs1	-11148.0	8577.0
Nfya	-12328.0	12716.0
Nfyb	-7061.0	7045.0
Nfyc	-3343.0	5943.0
Nhlrc1	-9140.0	10462.0
Nme1	7692.0	-11712.0
Nme3	1803.5	-1222.5
Nme4	3232.0	10814.0
Nmnat1	12337.0	-11274.0
Nmnat2	-3958.0	10749.0
Nmnat3	-7777.0	9871.0
Nmral1	-9112.0	9716.0
Nmrk1	-7016.0	-13036.0
Nnmt	11136.0	-12817.0
Nnt	15395.0	-15153.0
Nos3	-5834.0	9984.0
Nosip	10655.0	-4916.0
Nostrin	7594.0	-8185.0
Npas2	-10994.0	12702.0
Nqo1	12766.0	-5072.0
Nqo2	-2589.0	6974.0
Nr1d1	8240.0	12909.0
Nr1h2	6078.0	4986.0
Nr1h3	-10153.0	10155.0
Nr1h4	8223.0	-14409.0
Nrf1	-9261.0	4274.0
Nsdhl	14594.0	-13507.0
Nt5c	12844.0	-12104.0
Nt5c1a	8878.0	185.0
Nt5c2	-5848.0	5793.0
Nt5c3	-11402.0	7643.0
Nt5e	-9052.0	-9847.0
Nt5m	5668.0	7467.0
Nubp1	9700.0	7037.0
Nubp2	13143.0	4744.0
Nubpl	-8841.0	6873.0
Nudt1	-8758.0	9338.0
Nudt11	-11335.0	11352.0
Nudt12	-12240.0	11750.0
Nudt13	-2831.0	7049.0
Nudt15	3098.0	9353.0
Nudt16	-6578.0	10626.0
Nudt18	11966.0	5420.0
Nudt19	-12350.0	1782.0
Nudt3	-2718.0	3315.0
Nudt4	14212.0	-13513.0
Nudt5	3217.0	1965.0
Nudt7	5319.0	-8883.0
Nudt9	-5490.0	5587.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Oat	14211.0	-14408.0
Oaz1	-1927.0	8207.0
Oaz2	-11175.0	7564.0
Oaz3	9257.0	-6443.0
Oca2	3944.0	1486.0
Ocrl	12179.0	-11099.0
Odc1	-12658.0	12090.0
Ogdh	12207.0	-6438.0
Ogn	-10052.0	11508.0
Olah	876.5	-1222.5
Omd	-4734.0	8818.0
Oplah	12288.0	-11610.0
Ormdl2	-7564.0	-9040.0
Ormdl3	13731.0	-11977.0
Osbp	13051.0	-12726.0
Osbpl10	11352.0	-9298.0
Osbpl1a	15004.0	-15075.0
Osbpl2	-2523.0	8132.0
Osbpl3	-12550.0	12962.0
Osbpl5	15243.0	-14631.0
Osbpl6	-10347.0	11965.0
Osbpl7	12214.0	-5039.0
Osbpl8	-9954.0	-3772.0
Osbpl9	7841.0	-14061.0
Otc	-4507.0	-1222.5
Oxct1	-12581.0	12499.0
Oxct2b	10171.0	-7103.0
Pah	-12167.0	12288.0
Paics	10519.0	-13057.0
Pank1	-11546.0	1787.0
Pank2	-12195.0	12025.0
Pank3	7821.0	-15135.0
Pank4	5547.0	-8443.0
Paox	12712.0	-8841.0
Papss1	-8777.0	11499.0
Papss2	12971.0	-12114.0
Parp10	-7722.0	12980.0
Parp14	8349.0	-10305.0
Parp16	-11999.0	11193.0
Parp4	13827.0	-11490.0
Parp6	12740.0	-11408.0
Parp8	-11943.0	12513.0
Parp9	13337.0	-11796.0
Pcbd1	10683.0	-12253.0
Pcca	-12642.0	11782.0
Pccb	-11508.0	11532.0
Pck1	15049.0	-15032.0
Pck2	12500.0	2592.0
Pctp	-5841.0	10023.0
Pcx	-10992.0	8150.0
Pcyt1a	7322.0	-9575.0
Pcyt1b	-4684.5	8592.0
Pcyt2	-12540.0	12932.0
Pdha1	10727.0	-14169.0
Pdhb	13003.0	-14216.0
Pdhx	2479.0	6526.0
Pdk1	15240.0	-15026.0
Pdk2	14561.0	-9436.0
Pdk3	-11623.0	5982.0
Pdk4	9148.0	-14877.0
Pdp1	13244.0	-14167.0
Pdp2	-12232.0	12954.0
Pdpr	-11101.0	5405.0
Pdss1	-12371.0	8266.0
Pdss2	-10277.0	9698.0
Pdxk	15382.0	-15130.0
Pdzd11	-6450.0	2974.0
Pecr	-12610.0	12770.0
Pemt	-2449.0	211.0
Pex11a	10395.0	-15126.0
Pfas	-4374.0	12190.0
Pfkfb1	12567.0	-13215.0
Pfkfb2	2458.0	-251.0
Pfkfb3	12223.0	-13967.0
Pfkfb4	-4106.0	10898.0
Pfkl	15123.0	-14796.0
Pfkm	13360.0	10072.0
Pfkp	15099.0	-14437.0
Pgam1	14351.0	-13615.0
Pgam2	10491.0	12436.0
Pgd	11109.0	10821.0
Pgk1	14769.0	-14051.0
Pgls	13568.0	-10712.0
Pgm1	13229.0	5015.0
Pgm2	-2606.0	-7192.0
Pgm2l1	7013.0	-14702.0
Pgp	-3131.0	7511.0
Pgs1	5515.0	8588.0
Phgdh	11783.0	-3454.0
Phka1	-8222.0	10926.0
Phka2	-7407.0	-3034.0
Phkb	-9977.0	6191.0
Phkg1	14426.0	-3632.0
Phkg2	14184.0	-11887.0
Phospho1	9846.0	-10338.0
Phyh	-7846.0	9323.0
Phykpl	-6154.0	8990.0
Pi4k2a	10363.0	10743.0
Pi4k2b	15182.0	-14861.0
Pi4ka	-12166.0	10193.0
Pi4kb	-1097.0	-5397.0
Pias4	-9679.0	8206.0
Pik3c2a	12136.0	-13889.0
Pik3c2b	-9197.0	12682.0
Pik3c2g	-11796.0	12681.0
Pik3c3	-8989.0	6143.0
Pik3ca	5274.0	-12270.0
Pik3cb	-11168.0	9586.0
Pik3cd	-8249.0	9542.0
Pik3cg	-10587.0	8480.0
Pik3r1	-5226.0	4551.0
Pik3r2	-4478.0	11254.0
Pik3r3	13321.0	6430.0
Pik3r4	-6891.0	11427.0
Pik3r5	-9807.0	7727.0
Pik3r6	-10358.0	10810.0
Pikfyve	-1029.0	-4870.0
Pip4k2a	-11376.0	12197.0
Pip4k2b	-11013.0	10436.0
Pip4k2c	12482.0	-3617.0
Pip5k1a	12852.0	-12556.0
Pip5k1b	12425.0	-5434.0
Pip5k1c	12377.0	9141.0
Pipox	-11536.0	10316.0
Pitpnb	9730.0	2604.0
Pitpnm1	14517.0	-11612.0
Pitpnm2	-10627.0	9564.0
Pitpnm3	11435.0	-5928.0
Pklr	15118.0	-15004.0
Pkm	15349.0	-14908.0
Pla1a	14967.0	-14981.0
Pla2g10	-762.5	-1222.5
Pla2g12a	15144.0	-12990.0
Pla2g15	8626.0	6338.0
Pla2g1b	6684.0	-7304.0
Pla2g2d	4939.0	-7260.0
Pla2g2e	9364.0	-7775.0
Pla2g3	6101.0	-311.0
Pla2g4a	12836.0	-11551.0
Pla2g4b	-9798.0	3345.0
Pla2g4c	4031.0	-8816.0
Pla2g4d	3815.0	-3967.0
Pla2g4f	5176.0	3489.0
Pla2g5	-6543.0	12743.0
Pla2g6	-10758.0	6881.0
Pla2r1	-11857.0	11669.0
Plb1	11909.0	-13201.0
Plbd1	-4168.0	4540.0
Plcb1	-7289.0	1115.0
Plcb2	-11254.0	12407.0
Plcb3	-10411.0	12326.0
Plcb4	14571.0	-14383.0
Plcd1	12308.0	-11105.0
Plcd3	-6067.0	-3554.0
Plcd4	15296.0	6658.0
Plce1	9230.0	11606.0
Plcg1	15140.0	-14853.0
Plcg2	-2480.0	12667.0
Plch1	14701.0	-14802.0
Plch2	14434.0	-14451.0
Pld1	-9352.0	9867.0
Pld2	11129.0	-9881.0
Pld3	13065.0	-8831.0
Pld4	-3795.0	9934.0
Pld6	8927.0	-3254.0
Plekha1	14378.0	-13910.0
Plekha2	-10414.0	11827.0
Plekha3	8381.0	-6060.0
Plekha4	10905.0	6119.0
Plekha5	7454.0	-12641.0
Plekha6	-12700.0	13018.0
Plekha8	-7308.0	-9270.0
Plin1	-6430.0	8717.0
Plin2	5475.0	-11497.0
Plin3	14124.0	-6890.0
Plpp1	6481.0	6607.0
Plpp2	13317.0	-14346.0
Plpp3	-9843.0	9409.0
Plpp6	-10039.0	9047.0
Pm20d1	-11824.0	12257.0
Pmvk	14546.0	-14718.0
Pnmt	876.5	-1222.5
Pnp	-7095.0	-3297.0
Pnpla2	15003.0	-14556.0
Pnpla3	-9452.0	-10788.0
Pnpla6	12433.0	-11104.0
Pnpla7	14349.0	-12982.0
Pnpla8	3428.0	-14828.0
Pnpo	-8820.0	10801.0
Podxl2	9611.0	-10375.0
Pold1	5255.0	4543.0
Pom121	9659.0	-12785.0
Pomc	-7246.0	6332.0
Pon1	-6513.0	-3999.0
Pon2	-7617.0	-12860.0
Pon3	9692.0	-10911.0
Por	-11032.0	-7997.0
Ppa1	13552.0	-14128.0
Ppa2	-10837.0	1791.0
Ppara	-7949.0	-13305.0
Ppard	-9556.0	12160.0
Pparg	-8668.0	8335.0
Ppargc1a	15084.0	-14366.0
Ppargc1b	-8822.0	9634.0
Ppat	14775.0	-13591.0
Ppcdc	5758.0	-9986.0
Ppcs	-9655.0	5203.0
Ppip5k1	14638.0	-13574.0
Ppip5k2	-3235.0	10876.0
Ppm1k	14643.0	-11680.0
Ppm1l	-5425.0	4836.0
Ppox	4470.0	2629.0
Ppp1ca	12508.0	-5813.0
Ppp1cb	4565.0	-10643.0
Ppp1cc	13589.0	-11988.0
Ppp1r3c	12871.0	5851.0
Ppp2ca	2443.0	326.0
Ppp2cb	14291.0	-13381.0
Ppp2r1a	11507.0	3755.0
Ppp2r1b	-3062.0	-7202.0
Ppp2r5d	11554.0	1834.0
Ppt1	-12357.0	12064.0
Ppt2	-12428.0	12278.0
Prelp	-7348.0	11322.0
Prkaa2	-10700.0	7488.0
Prkab2	-7030.0	7551.0
Prkaca	-8030.0	10329.0
Prkacb	-256.0	3728.0
Prkag2	13805.0	-7.0
Prkar1a	12224.0	-10675.0
Prkar1b	12793.0	4753.0
Prkar2a	13537.0	-12751.0
Prkar2b	-11024.0	2146.0
Prkca	-11577.0	11021.0
Prkd1	4516.0	-6995.0
Prkd2	-8331.0	10908.0
Prkd3	-12774.0	12989.0
Prkg2	10951.0	-4648.0
Prodh	10521.0	7441.0
Prodh2	-3986.0	-7482.0
Prps1l3	-12151.0	10590.0
Prps2	11644.0	8728.0
Psap	-285.0	9042.0
Psat1	11508.0	-13101.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Psph	13653.0	-12194.0
Pstk	-9537.0	9420.0
Ptdss1	-2510.0	316.0
Ptdss2	15238.0	-14968.0
Pten	-7730.0	9006.0
Ptgds	15133.0	-15080.0
Ptges	13828.0	12500.0
Ptges2	6243.0	338.0
Ptges3	-12133.0	6834.0
Ptgis	13666.0	-12770.0
Ptgr1	11555.0	-14117.0
Ptgr2	-6677.0	-4982.0
Ptgs1	14471.0	-8744.0
Ptgs2	10473.0	-11024.0
Ptpn13	-8710.0	11683.0
Pts	4797.0	-10650.0
Pxmp2	10094.0	-13097.0
Pycr1	-4157.0	-4517.0
Pycr2	14050.0	-10135.0
Pycrl	-7439.0	-4811.0
Pygb	15276.0	-12974.0
Pygl	13404.0	-5020.0
Pygm	-4881.0	11121.0
Qdpr	12216.0	-7878.0
Qprt	-11368.0	8472.0
Rab14	-10689.0	10187.0
Rab4a	14183.0	-14552.0
Rab5a	-3232.0	-8180.0
Rae1	-2818.0	7959.0
Ran	-340.0	-458.0
Ranbp2	-1884.0	-9227.0
Rap1a	-234.0	-12456.0
Rapgef3	-12024.0	-6345.0
Rapgef4	7283.0	-3093.0
Rbks	9098.0	4025.0
Rbp1	-1593.0	6512.0
Rbp2	13643.0	-10297.0
Rbp4	2769.0	-12637.0
Rdh11	14805.0	-13406.0
Retsat	3395.0	-12949.0
Rfk	14573.0	-15061.0
Rgl1	-12543.0	12112.0
Rida	-4082.0	-14194.0
Rimkla	11540.0	3444.0
Rimklb	-9845.0	-4853.0
Rnls	-8919.0	9612.0
Rora	-11262.0	-14166.0
Rpe	-4526.0	-4869.0
Rpia	-10467.0	349.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rrm1	13273.0	-4994.0
Rrm2	14293.0	-13094.0
Rrm2b	-9365.0	-3023.0
Rtel1	5442.0	9777.0
Rufy1	5647.0	2013.0
Rxra	78.0	-5092.0
Rxrb	-9054.0	11845.0
Sacm1l	9967.0	-13940.0
Samd8	-11726.0	10917.0
Samhd1	-5671.0	6219.0
Sar1b	2357.0	-12462.0
Sardh	-11194.0	11048.0
Sat1	13951.0	-13619.0
Sbf1	10421.0	-9236.0
Sbf2	4326.0	4192.0
Sc5d	-10946.0	10735.0
Scap	8767.0	9243.0
Scd4	10817.0	-12595.0
Scly	-9905.0	9810.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Scp2	-7651.0	-11472.0
Sdc1	14043.0	1649.0
Sdc2	-11747.0	10378.0
Sdc3	-8537.0	11348.0
Sdc4	-5140.0	12375.0
Sdha	7583.0	-6150.0
Sdhb	14750.0	-14069.0
Sdhc	-6156.0	-7176.0
Sdhd	15189.0	-14923.0
Sds	-1128.0	-3689.5
Sdsl	9976.0	-7013.0
Sec13	9849.0	-12486.0
Sec23a	7407.0	-13704.0
Sec24a	5790.0	-8954.0
Sec24b	7763.0	-9364.0
Sec24c	-9214.0	6352.0
Sec24d	-7723.0	4787.0
Secisbp2	-9337.0	10086.0
Seh1l	9415.0	-7505.0
Sephs2	-10506.0	11018.0
Sepsecs	-12324.0	11433.0
Serinc1	-10068.0	-12264.0
Serinc2	-11788.0	9012.0
Serinc3	13906.0	-14551.0
Serinc4	6462.0	-7859.0
Serinc5	13682.0	-12585.0
Serpina6	11070.0	-11790.0
Sgms1	-1126.0	-13684.0
Sgms2	10674.0	3472.0
Sgpl1	15009.0	-10787.0
Sgpp1	-10592.0	12788.0
Sgpp2	13988.0	-13600.0
Sgsh	-8277.0	12291.0
Shmt1	15258.0	-14887.0
Shmt2	-4109.0	4185.0
Shpk	12327.0	-11634.0
Sin3a	-4457.0	256.0
Sin3b	12589.0	-8232.0
Slc10a1	-11318.0	10430.0
Slc10a2	11475.0	-14309.0
Slc16a1	14346.0	-8035.0
Slc16a3	11553.0	-11018.0
Slc16a8	11805.0	-13519.0
Slc19a1	14721.0	-14297.0
Slc19a2	14485.0	11582.0
Slc19a3	11867.0	-15059.0
Slc22a1	5036.0	4679.0
Slc22a13b-ps	4934.0	-11650.0
Slc22a2	-12013.0	9585.0
Slc22a3	13467.0	4674.0
Slc22a5	-8530.0	5749.0
Slc23a1	15007.0	-15077.0
Slc23a2	9653.0	2946.0
Slc25a1	7798.0	-8481.0
Slc25a10	4794.0	-10546.0
Slc25a11	12566.0	-9400.0
Slc25a12	15159.0	-10019.0
Slc25a13	-8801.0	-10830.0
Slc25a14	-5941.0	2591.0
Slc25a15	-10444.0	11979.0
Slc25a16	14866.0	-13605.0
Slc25a17	10195.0	-14963.0
Slc25a19	-10542.0	12729.0
Slc25a2	-6038.0	8096.0
Slc25a20	6077.0	-13402.0
Slc25a21	-11336.0	8844.0
Slc25a27	7582.0	-4450.0
Slc25a28	9501.0	-4895.0
Slc25a32	10474.0	-12650.0
Slc25a37	-11023.0	11148.0
Slc25a44	13241.0	-13126.0
Slc26a1	-12048.0	12878.0
Slc26a2	-9372.0	2909.0
Slc27a1	14396.0	-13771.0
Slc27a2	-12611.0	-158.0
Slc27a3	-10455.0	12267.0
Slc27a5	6548.0	-10103.0
Slc2a1	13277.0	-7613.0
Slc2a2	14424.0	-9637.0
Slc2a3	-9664.0	4925.0
Slc35b2	-8665.0	8387.0
Slc35b3	12182.0	-12724.0
Slc35d1	12156.0	-14255.0
Slc35d2	-7802.0	5124.0
Slc36a4	13705.0	-12774.0
Slc37a1	13012.0	-11840.0
Slc37a2	-8352.0	7658.0
Slc37a4	14589.0	-14261.0
Slc3a2	12234.0	-4863.0
Slc44a1	-6813.0	1668.0
Slc44a2	13092.0	9189.0
Slc44a3	14832.0	-140.0
Slc44a4	-12183.0	11751.0
Slc44a5	242.0	-7344.0
Slc45a2	10416.0	-10692.0
Slc46a1	-8716.0	4783.0
Slc52a2	-11258.0	10312.0
Slc52a3	-11197.0	1949.0
Slc5a5	8692.0	-4531.0
Slc5a6	8073.0	9275.0
Slc5a8	9361.0	-14435.0
Slc6a11	1803.5	-2073.5
Slc6a12	15137.0	-15079.0
Slc6a7	10389.0	-11196.0
Slc7a5	14136.0	-14270.0
Slc9a1	11956.0	-5779.0
Slco1a1	-11393.0	10971.0
Slco1b2	-5651.0	10208.0
Slco2b1	-4473.0	12205.0
Smarcd3	14278.0	-13359.0
Smox	-9435.0	12233.0
Smpd1	-5842.0	10572.0
Smpd2	-3211.0	3842.0
Smpd3	7026.0	4703.0
Smpd4	-65.0	6230.0
Sms	-10656.0	7982.0
Snap25	5976.5	-6281.0
Sord	-4341.0	5729.0
Sp1	-10774.0	4387.0
Sphk1	14600.0	-15084.0
Sphk2	384.0	8148.0
Spns2	-9260.0	11417.0
Spr	-8314.0	2791.0
Sptlc1	-12432.0	10787.0
Sptlc2	13546.0	-13752.0
Sptlc3	-5695.0	-11944.0
Sptssa	-10245.0	10360.0
Sptssb	5202.0	-5736.0
Sqle	15109.0	-14109.0
Sqrdl	6576.0	-8275.0
Srd5a1	-12063.0	11755.0
Srd5a2	-12725.0	12726.0
Srd5a3	6436.0	6671.0
Srebf1	8087.0	-9710.0
Srebf2	-4237.0	9342.0
Srm	-3953.0	3596.0
Srr	-11776.0	11131.0
St3gal1	-8130.0	9896.0
St3gal2	12577.0	-7985.0
St3gal3	12722.0	-11643.0
St3gal4	5433.0	-4842.0
St3gal6	11657.0	-10826.0
St6galnac6	2401.0	10428.0
Stab2	10570.0	10668.0
Star	10701.0	-12713.0
Stard10	-8217.0	5213.0
Stard3	-9897.0	-5931.0
Stard3nl	-10407.0	10461.0
Stard4	11739.0	-14791.0
Stard5	10647.0	-12414.0
Stard6	7007.0	5863.0
Stard7	4898.0	5672.0
Stk11	-4042.0	10593.0
Stx1a	5988.0	1092.0
Stxbp1	10299.0	3684.0
Sucla2	275.0	-12058.0
Suclg1	12169.0	-12783.0
Suclg2	-7679.0	5102.0
Sult1a1	15293.0	-14966.0
Sult1b1	13802.0	-13486.0
Sult1c2	-9587.0	12986.0
Sult1e1	5976.5	1772.0
Sult2b1	9920.0	-11409.0
Sult4a1	12512.0	-6437.0
Sumf1	12316.0	-13154.0
Sumf2	-9718.0	10648.0
Sumo2	-7839.0	5714.0
Suox	11989.0	-5545.0
Surf1	10929.0	-8571.0
Synj1	-1144.0	495.0
Synj2	11658.0	9150.0
Syt5	9418.0	-4881.0
Taco1	-5127.0	3445.0
Taldo1	-9735.0	9231.0
Tat	6864.0	-12923.0
Taz	11856.0	-12310.0
Tbl1xr1	-8741.0	-12237.0
Tbxas1	-12188.0	12857.0
Tcn2	-10668.0	3920.0
Tdo2	-4266.0	-6861.0
Tecr	8246.0	-13157.0
Tgs1	-7102.0	2547.0
Th	876.5	-1222.5
Them4	10861.0	-13949.0
Them5	12294.0	-8708.0
Thrap3	7951.0	-7948.0
Thrsp	14854.0	-13520.0
Thtpa	-11837.0	12203.0
Tiam2	-6226.0	500.0
Timmdc1	-7729.0	8038.0
Tk1	-11584.0	10053.0
Tk2	11630.0	-9205.0
Tkfc	11723.0	-13379.0
Tkt	15217.0	-13539.0
Tm7sf2	11166.0	-8065.0
Tmem126b	-11814.0	6995.0
Tmem186	-10081.0	10176.0
Tmem55b	14314.0	-12520.0
Tmem86b	-10586.0	10006.0
Tmlhe	-10942.0	5100.0
Tnfaip8	-12457.0	11290.0
Tnfaip8l1	-6384.0	11291.0
Tnfaip8l2	3422.0	-420.0
Tnfaip8l3	7867.0	-180.0
Tnfrsf21	10950.0	-14900.0
Tph1	-1131.5	3286.0
Tph2	9628.0	-10386.0
Tpi1	12212.0	-9334.0
Tpk1	-12334.0	5790.0
Tpmt	4229.0	-12679.0
Tpo	9823.0	-10576.0
Tpr	-7568.0	-3358.0
Tpst1	-8868.0	10864.0
Tpst2	12150.0	5304.0
Tpte	5232.0	-5464.0
Trap1	-11794.0	8106.0
Trib3	13141.0	-7115.0
Trmt112	-11645.0	12227.0
Tspo	11761.0	-13425.0
Tst	-11064.0	9797.0
Tstd1	-10895.0	12049.0
Ttpa	14930.0	-14746.0
Ttr	8444.0	-14416.0
Txn1	-6434.0	-12085.0
Txn2	-2645.0	-7555.0
Txnrd1	-10298.0	11671.0
Tymp	13001.0	-13260.0
Tyms	7851.0	-10098.0
Tyrp1	7513.0	-8064.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2i	13984.0	-13775.0
Ubiad1	-12675.0	11585.0
Uck1	8766.0	-7950.0
Uck2	11895.0	207.0
Uckl1	4864.0	-5056.0
Ucp1	2923.0	-2898.0
Ucp2	14325.0	-14886.0
Ucp3	10070.0	-13365.0
Ugcg	-10356.0	4398.0
Ugdh	12363.0	-10583.0
Ugp2	7812.0	-13729.0
Ugt1a1	15247.0	-15108.0
Ugt1a2	15365.0	-15146.0
Ugt1a6b	-7002.0	11244.0
Ugt1a9	15065.0	-14593.0
Ugt2a1	1803.5	-1222.5
Ugt2a2	876.5	-1222.5
Ugt2a3	-11497.0	10242.0
Ugt2b34	14732.0	-15015.0
Ugt3a1	-12556.0	8006.0
Ugt8a	-12755.0	12880.0
Umps	13479.0	-10765.0
Upb1	14719.0	-14038.0
Upp1	14103.0	-14787.0
Upp2	11680.0	-11170.0
Uqcr10	14874.0	-14710.0
Uqcr11	13121.0	-13943.0
Uqcrb	15145.0	-15118.0
Uqcrc1	12486.0	-6849.0
Uqcrc2	12361.0	-13694.0
Uqcrfs1	11242.0	-12436.0
Uqcrh	15179.0	-15073.0
Uqcrq	15160.0	-14637.0
Uroc1	12757.0	-13430.0
Urod	6740.0	-12506.0
Uros	-11905.0	11229.0
Ust	-7879.0	7314.0
Vac14	-4694.0	10751.0
Vamp2	10726.0	-10983.0
Vapa	8241.0	-4684.0
Vapb	-9646.0	7751.0
Vcan	-4744.0	4092.0
Vdac1	2808.0	-11375.0
Vdr	-9663.0	9673.0
Vkorc1	-6765.0	2722.0
Vnn1	12806.0	-14298.0
Wasl	6310.0	-10820.0
Xdh	15177.0	-14327.0
Xylb	-12425.0	12775.0
Xylt1	-12292.0	12885.0
Xylt2	13054.0	6006.0
Zdhhc21	-5023.0	-3544.0

---

---

Extracellular-matrix-organization

Extracellular-matrix-organization

metric	value
setSize	274
pMANOVA	3.06e-12
p.adjustMANOVA	1.26e-10
s.dist	0.217
s.diab	-0.0423
s.PMX	0.212
p.diab	0.227
p.PMX	1.35e-09

Top 20 genes

Gene	diab	PMX
Ltbp4	-12699	12990
Pdgfb	-12651	12999
Col6a3	-12679	12949
Kdr	-12645	12884
Itgax	-12597	12908
Col6a6	-12588	12839
Mmp13	-12568	12806
Col19a1	-12637	12670
Lama4	-12738	12562
Itgb7	-12362	12913
Adamts5	-12221	12881
Col15a1	-12288	12764
Itga9	-12089	12867
Itgb6	-12023	12923
Lama2	-12274	12567
Lamc3	-12142	12570
Col1a1	-11876	12828
Itgal	-11771	12813
Ntn4	-11679	12792
Ltbp1	-11684	12694

Click HERE to show all gene set members

All member genes

	diab	PMX
A2m	-11340.0	9422.0
Actn1	-2955.0	-9395.0
Adam10	-3927.0	-9154.0
Adam12	-11433.0	12891.0
Adam15	11663.0	-6853.0
Adam17	-4289.0	8876.0
Adam19	-11622.0	12621.0
Adam8	-10873.0	11469.0
Adam9	-10555.0	9664.0
Adamts1	-10038.0	1773.0
Adamts14	8013.0	9277.0
Adamts16	-7929.0	12183.0
Adamts18	-3577.0	5176.5
Adamts2	-8208.0	11465.0
Adamts3	7359.0	-4902.0
Adamts4	13837.0	-7672.0
Adamts5	-12221.0	12881.0
Adamts8	-7262.0	-9797.0
Adamts9	-4301.0	5977.0
Agrn	-2557.0	10075.0
Aspn	-1917.0	-7778.0
Bcan	1803.5	-1222.5
Bgn	-2592.0	8406.0
Bmp1	14580.0	-13984.0
Bmp2	-9638.0	11266.0
Bmp4	-4421.0	-13702.0
Bmp7	14233.0	10318.0
Bsg	10831.0	-9772.0
Capn1	15297.0	-14590.0
Capn10	3174.0	4742.0
Capn11	-5491.0	-5745.0
Capn12	-3451.0	4933.0
Capn13	11416.0	-10837.0
Capn15	8306.0	5698.0
Capn2	14380.0	-14044.0
Capn3	12102.0	-7434.0
Capn5	15037.0	-12909.0
Capn6	-2555.0	12372.0
Capn7	-1726.0	-9173.0
Capn8	8090.0	-2353.0
Capn9	7215.0	-9246.0
Capns1	10893.0	-14245.0
Capns2	-3872.0	8278.0
Cask	13958.0	-14155.0
Casp3	13749.0	-9807.0
Cast	13527.0	-11562.0
Cd151	12960.0	-12761.0
Cd44	-11921.0	11492.0
Cd47	-5391.0	-2458.0
Cdh1	-174.0	12292.0
Ceacam1	10562.0	8936.0
Col10a1	-2109.5	2317.5
Col11a1	12321.0	-13346.0
Col11a2	12863.0	-4622.0
Col12a1	15368.0	-15045.0
Col13a1	13283.0	-13105.0
Col14a1	-10995.0	12871.0
Col15a1	-12288.0	12764.0
Col16a1	-12297.0	11347.0
Col17a1	13341.0	-11901.0
Col18a1	12226.0	5466.0
Col19a1	-12637.0	12670.0
Col1a1	-11876.0	12828.0
Col1a2	-11440.0	12535.0
Col20a1	2882.0	-10226.0
Col22a1	4537.0	498.0
Col23a1	6766.0	-9684.0
Col24a1	10532.0	10558.0
Col25a1	3436.0	1957.0
Col26a1	-1506.0	1907.0
Col27a1	-1197.0	-14575.0
Col28a1	-5617.0	7126.0
Col2a1	10763.0	-8045.0
Col3a1	-11632.0	12352.0
Col4a1	5904.0	7644.0
Col4a2	12342.0	7010.0
Col4a3	-8719.0	8992.0
Col4a4	-10655.0	12060.0
Col4a5	12326.0	7452.0
Col4a6	11959.0	-9813.0
Col5a1	-11641.0	12528.0
Col5a2	-10944.0	1711.0
Col5a3	-9144.0	12493.0
Col6a1	-6512.0	11992.0
Col6a2	-4892.0	11714.0
Col6a3	-12679.0	12949.0
Col6a5	-7827.0	12669.0
Col6a6	-12588.0	12839.0
Col7a1	14443.0	-13861.0
Col8a1	7087.0	-13061.0
Col8a2	-1046.0	8648.0
Col9a1	-1304.5	3868.0
Col9a2	4094.0	1499.0
Col9a3	-7324.0	5896.0
Colgalt1	14731.0	-9307.0
Colgalt2	11005.0	269.0
Comp	13019.0	-12258.0
Crtap	-9940.0	8781.0
Ctrb1	-485.5	-1222.5
Ctsb	14369.0	-12695.0
Ctsd	14947.0	-9938.0
Ctsk	53.0	-6167.0
Ctsl	10079.0	-12537.0
Ctss	-6439.0	-7173.0
Dag1	14086.0	305.0
Dcn	-9149.0	12256.0
Ddr1	-9753.0	11421.0
Ddr2	-10483.0	10305.0
Dmd	7573.0	-6771.0
Dmp1	-377.5	-1222.5
Dst	12167.0	-12864.0
Efemp1	14794.0	-12725.0
Efemp2	-4221.0	4471.0
Eln	12993.0	9537.0
F11r	11089.0	-13222.0
Fbln1	8104.0	2140.0
Fbln2	3253.0	9693.0
Fbln5	-9968.0	12063.0
Fbn1	-1557.0	11139.0
Fbn2	5734.0	-7055.0
Fga	14188.0	-14645.0
Fgb	13155.0	-10094.0
Fgf2	-1912.0	2640.0
Fgg	14936.0	-14182.0
Fmod	-8347.0	7370.0
Fn1	12346.0	6126.0
Furin	-1107.0	-210.0
Gdf5	-45.0	6136.0
Hapln1	-9377.0	8740.0
Hspg2	-9709.0	12765.0
Htra1	-12119.0	11724.0
Icam1	12408.0	-14411.0
Icam2	-10654.0	12128.0
Icam4	-187.0	1799.0
Icam5	-4768.0	7615.0
Itga1	9086.0	6502.0
Itga10	-7763.0	-6633.0
Itga11	11456.0	11485.0
Itga2	7236.0	-6041.0
Itga2b	4836.0	-5064.0
Itga3	9099.0	6566.0
Itga4	-10182.0	12732.0
Itga5	-6316.0	4295.0
Itga6	10749.0	-2876.0
Itga7	11604.0	-4725.0
Itga8	-9554.0	11089.0
Itga9	-12089.0	12867.0
Itgad	-3776.0	1513.5
Itgae	-4002.0	8879.0
Itgal	-11771.0	12813.0
Itgam	-8058.0	4871.0
Itgav	14776.0	-14797.0
Itgax	-12597.0	12908.0
Itgb1	5869.0	-13098.0
Itgb2l	4949.0	-3001.0
Itgb3	12310.0	-13769.0
Itgb4	14708.0	-12358.0
Itgb5	3113.0	12053.0
Itgb6	-12023.0	12923.0
Itgb7	-12362.0	12913.0
Itgb8	-8645.0	-5178.0
Jam2	-8656.0	-7659.0
Jam3	-11372.0	12730.0
Kdr	-12645.0	12884.0
Klk1b8	-1582.0	1255.0
Klkb1	8412.0	9814.0
Lama1	-6518.0	12437.0
Lama2	-12274.0	12567.0
Lama3	-9254.0	7235.0
Lama4	-12738.0	12562.0
Lama5	14788.0	-8076.0
Lamb1	-8857.0	11401.0
Lamb2	7606.0	8928.0
Lamb3	12930.0	-13656.0
Lamc1	13297.0	-9372.0
Lamc2	15047.0	-12749.0
Lamc3	-12142.0	12570.0
Lox	14161.0	-13710.0
Loxl1	2823.0	6259.0
Loxl2	3876.0	10967.0
Loxl3	9002.0	7034.0
Loxl4	12921.0	-2856.0
Lrp4	10858.0	-14054.0
Ltbp1	-11684.0	12694.0
Ltbp2	12900.0	-12290.0
Ltbp3	14877.0	4164.0
Ltbp4	-12699.0	12990.0
Lum	-2412.0	11141.0
Madcam1	4094.0	-2795.0
Matn1	5962.5	-5271.5
Matn4	-124.0	10469.0
Mfap1b	8262.0	-8493.0
Mfap2	11466.0	1600.0
Mfap3	4645.0	2933.0
Mfap4	-5567.0	10509.0
Mfap5	-6636.0	4266.0
Mmp10	1803.5	-1222.5
Mmp11	-7058.0	11721.0
Mmp12	-11589.0	11200.0
Mmp13	-12568.0	12806.0
Mmp14	5281.0	8173.0
Mmp15	-8045.0	12650.0
Mmp16	-5289.0	-2799.0
Mmp17	10754.0	-193.0
Mmp19	-8240.0	6961.0
Mmp2	14979.0	-11708.0
Mmp20	10584.0	-11800.0
Mmp24	37.0	-10081.0
Mmp25	-4649.0	9272.0
Mmp3	3320.0	2802.0
Mmp7	2566.5	6564.0
Mmp8	4610.0	-12572.0
Mmp9	-9378.0	9026.0
Musk	12826.0	-8639.0
Ncam1	13434.0	-8163.0
Ncstn	14410.0	-12169.0
Nid1	-9338.0	12039.0
Nid2	11076.0	9335.0
Nrxn1	-5829.0	-4990.0
Ntn4	-11679.0	12792.0
Optc	4546.0	5291.0
P3h1	7658.0	3025.0
P3h2	8443.0	-9992.0
P3h3	-8506.0	11805.0
P4ha1	-12001.0	4864.0
P4ha2	-7245.0	-51.0
P4ha3	-20.0	1892.0
P4hb	-11855.0	7508.0
Pcolce	14234.0	3916.0
Pcolce2	10772.0	-5809.0
Pdgfa	10828.0	5978.0
Pdgfb	-12651.0	12999.0
Pecam1	-9053.0	12320.0
Phykpl	-6154.0	8990.0
Plec	11898.0	-8539.0
Plg	-5865.0	5097.0
Plod1	-9830.0	8095.0
Plod2	-12262.0	7867.0
Plod3	4212.0	-176.0
Ppib	12075.0	-13309.0
Prkca	-11577.0	11021.0
Psen1	-11531.0	9651.0
Ptprs	13493.0	10865.0
Pxdn	-9185.0	10940.0
Scube1	-3618.0	8650.0
Scube3	-10871.0	12398.0
Sdc1	14043.0	1649.0
Sdc2	-11747.0	10378.0
Sdc3	-8537.0	11348.0
Sdc4	-5140.0	12375.0
Serpine1	-11951.0	6456.0
Serpinh1	-11889.0	11493.0
Sh3pxd2a	13790.0	1124.0
Sparc	8888.0	8130.0
Spock3	-8882.0	6466.0
Spp1	15190.0	-14758.0
Tgfb1	-11489.0	7819.0
Tgfb2	10894.0	136.0
Tgfb3	9382.0	-6441.0
Thbs1	4377.0	10927.0
Timp1	-9680.0	7322.0
Timp2	7815.0	3399.0
Tll1	-9546.0	11305.0
Tll2	8607.0	4261.0
Tmprss6	9249.0	-13432.0
Tnc	5679.0	9966.0
Tnn	14359.0	-14547.0
Tnr	-2816.0	983.0
Tnxb	-9912.0	12280.0
Trappc4	-8784.0	11690.0
Ttr	8444.0	-14416.0
Vcam1	-10545.0	8429.0
Vcan	-4744.0	4092.0
Vtn	-9042.0	-9360.0

---

---

Cellular-responses-to-stress

Cellular-responses-to-stress

metric	value
setSize	635
pMANOVA	5.02e-09
p.adjustMANOVA	2.01e-07
s.dist	0.169
s.diab	0.0905
s.PMX	-0.143
p.diab	9.39e-05
p.PMX	6.95e-10

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Sult1a1	15293	-14966
Rplp1	15259	-14929
Cox6b1	15253	-14902
Rpl32	15195	-14957
Rps11	15181	-14944
Cox6c	15087	-15036
Hdac6	15227	-14879
Txnip	15044	-15001
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Atp6v0e	14931	-14952
Ppp1r15a	14992	-14845
Cox5a	15090	-14747
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Acadvl	8255.0	-13764.0
Acd	-4896.0	9107.0
Actr10	8979.0	4659.0
Actr1a	10383.0	-8216.0
Add1	-10711.0	8903.0
Ago1	13694.0	-4416.0
Ago3	-10688.0	9354.0
Ago4	4723.0	6013.0
Ajuba	-11055.0	10965.0
Akt1s1	9188.0	-3366.0
Alb	-5186.0	-12238.0
Anapc1	-11278.0	10450.0
Anapc10	-40.0	-7692.0
Anapc11	-4767.0	-2276.0
Anapc15	-2513.0	-9553.0
Anapc16	13128.0	-13447.0
Anapc2	-3217.0	9388.0
Anapc4	14276.0	-12248.0
Anapc5	14536.0	-12088.0
Anapc7	10824.0	-6183.0
Apoa1	-4915.0	-14116.0
Apob	14399.0	-9778.0
Aqp8	13473.0	8867.0
Ar	2881.0	-13790.0
Arfgap1	7144.0	-11530.0
Arnt	7604.0	-12300.0
Arntl	-3021.0	9713.0
Asf1a	-6271.0	-233.0
Asns	14974.0	-13140.0
Atf2	-6723.0	3300.0
Atf3	5940.0	-10511.0
Atf4	10850.0	-13249.0
Atf5	15204.0	-14291.0
Atf6	-5207.0	-11001.0
Atm	11462.0	2585.0
Atox1	15063.0	-14006.0
Atp6v0b	4840.0	2125.0
Atp6v0c	3151.0	-10611.0
Atp6v0d1	203.0	1912.0
Atp6v0d2	15150.0	-3904.0
Atp6v0e	14931.0	-14952.0
Atp6v0e2	7872.0	6422.0
Atp6v1a	10227.0	-7433.0
Atp6v1b1	13172.0	12006.0
Atp6v1b2	-7304.0	5553.0
Atp6v1c1	12161.0	-10561.0
Atp6v1c2	14305.0	9508.0
Atp6v1d	12172.0	-14697.0
Atp6v1e1	13351.0	-11187.0
Atp6v1f	14121.0	-13473.0
Atp6v1g1	15089.0	-12782.0
Atp6v1g2	-3055.0	4701.0
Atp6v1g3	14162.0	-9021.0
Atp6v1h	9566.0	-8530.0
Atp7a	14760.0	-13906.0
Atr	4265.0	-9369.0
Bach1	-166.0	-14122.0
Bag1	15011.0	-14578.0
Bag2	14764.0	-14917.0
Bag3	6958.0	-3130.0
Bag4	14606.0	-13789.0
Bag5	-8551.0	7728.0
BC048403	8126.0	-4500.0
Blvra	14254.0	-15053.0
Blvrb	-9559.0	9965.0
Bmi1	-6546.0	9252.0
Cabin1	-3241.0	8514.0
Calr	-12155.0	11400.0
Camk2a	-8582.0	9297.0
Camk2b	12864.0	-14402.0
Camk2d	14624.0	-13868.0
Camk2g	-9180.0	8979.0
Capza2	9159.0	-12805.0
Capzb	4505.0	8343.0
Car9	-10836.0	5039.0
Carm1	8621.0	-6979.0
Cat	-10493.0	8958.0
Cbx2	-6995.0	8685.0
Cbx4	-12196.0	11468.0
Cbx6	-6489.0	12600.0
Cbx8	-11721.0	11385.0
Ccar2	-4891.0	11765.0
Ccna2	12043.0	-6678.0
Ccne1	8507.0	-10924.0
Ccne2	4837.0	-11061.0
Ccs	10222.0	-7052.0
Cdc16	10625.0	-286.0
Cdc23	180.0	8382.0
Cdc26	8205.0	-5823.0
Cdc27	-6730.0	-6274.0
Cdk2	12902.0	-12285.0
Cdk4	7497.0	6438.0
Cdk6	-8022.0	-8784.0
Cdkn1a	15394.0	-12557.0
Cdkn1b	4380.0	258.0
Cdkn2b	14383.0	-14293.0
Cdkn2c	-1158.0	9132.0
Cdkn2d	5293.0	2129.0
Cebpb	15167.0	-15133.0
Cebpg	-7894.0	-8449.0
Chac1	9497.0	-11449.0
Chd9	-8520.0	9935.0
Cited2	13876.0	-12832.0
Clec1b	11098.0	-12765.0
Clock	13462.0	-8810.0
Col4a6	11959.0	-9813.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Creb1	-10512.0	8785.0
Creb3	9940.0	-6204.0
Creb3l1	-11315.0	9056.0
Creb3l2	-11326.0	12802.0
Creb3l3	2849.0	-10313.0
Creb3l4	10042.0	-10791.0
Crebbp	7115.0	-7498.0
Crebrf	12563.0	-14625.0
Crtc1	-5952.0	10621.0
Crtc2	8982.0	-6795.0
Crtc3	-6336.0	2634.0
Cryab	14126.0	-15076.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Ctdsp2	9633.0	-12180.0
Cul1	114.0	-11623.0
Cul2	-7656.0	2073.0
Cul3	-5498.0	5923.0
Cul7	15078.0	7816.0
Cxxc1	-5408.0	9554.0
Cyba	-11001.0	9452.0
Cybb	-3640.0	4621.0
Cycs	8402.0	-13138.0
Dcp2	-11008.0	5190.0
Dcstamp	-1104.0	-3929.0
Dctn1	4613.0	8656.0
Dctn2	13574.0	-8129.0
Dctn3	13985.0	-13682.0
Dctn4	12982.0	-11645.0
Dctn5	-8689.0	10997.0
Dctn6	14486.0	-12682.0
Ddit3	13910.0	-13026.0
Ddx11	7225.0	-10933.0
Dedd2	14645.0	-11044.0
Depdc5	10603.0	-12516.0
Dis3	-10317.0	11084.0
Dnaja1	-12236.0	9878.0
Dnaja2	-5772.0	-8172.0
Dnaja4	-11188.0	7938.0
Dnajb1	-6536.0	7870.0
Dnajb11	-9969.0	6273.0
Dnajb6	-10294.0	-12881.0
Dnajb9	12791.0	-14995.0
Dnajc2	-8664.0	11294.0
Dnajc3	-9188.0	-13392.0
Dnajc7	12107.0	-10594.0
Dync1h1	12037.0	3704.0
Dync1i1	7564.0	7503.0
Dync1i2	13930.0	-14334.0
Dync1li1	10870.0	-10085.0
Dync1li2	13775.0	-14349.0
Dynll1	-10023.0	-2241.0
Dynll2	-12351.0	10871.0
E2f1	14773.0	-13127.0
E2f2	-10922.0	8773.0
E2f3	9873.0	3869.0
Edem1	-12574.0	11731.0
Eed	-9201.0	7028.0
Eef1a1	6403.0	-13665.0
Egln1	-12506.0	12895.0
Egln2	-5176.0	1141.0
Egln3	11444.0	-14851.0
Ehmt1	-4418.0	-10516.0
Ehmt2	4354.0	10437.0
Eif2ak1	3385.0	-5086.0
Eif2ak3	13308.0	-14103.0
Eif2ak4	12662.0	-12468.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Ep300	-10091.0	9600.0
Ep400	-6397.0	9291.0
Epas1	-10492.0	12228.0
Epo	12444.0	-7846.0
Erf	-4112.0	-11941.0
Ern1	-7176.0	10149.0
Ero1l	13872.0	-14020.0
Ets1	-12235.0	12571.0
Ets2	-11047.0	10868.0
Exosc1	-1652.0	-259.0
Exosc2	-4051.0	7454.0
Exosc3	-9773.0	11565.0
Exosc4	-6162.0	8972.0
Exosc5	-4859.0	4528.0
Exosc7	12464.0	-11384.0
Exosc8	-4592.0	-5642.0
Exosc9	14145.0	-12668.0
Extl1	14857.0	-13844.0
Extl2	13675.0	-4705.0
Extl3	-5757.0	11997.0
Ezh2	13058.0	-14025.0
Fabp1	13947.0	-14420.0
Fbxl17	-5253.0	9551.0
Fkbp14	14595.0	-13859.0
Fkbp4	-12401.0	11088.0
Fkbp5	8456.0	-14207.0
Flcn	8427.0	2620.0
Flt3l	-10231.0	11283.0
Fnip1	5376.0	-14121.0
Fnip2	6241.0	-11575.0
Fos	5077.0	22.0
Fzr1	-2715.0	9851.0
Gatsl2	10871.0	-9194.0
Gatsl3	-1475.0	8414.0
Gcn1l1	-8991.0	12087.0
Gfpt1	10435.0	-14180.0
Gm10263	6260.5	-6620.0
Gm11273	8317.0	-6691.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gml	2512.5	-2558.5
Gosr2	5078.0	3020.0
Gpx1	-3900.0	5605.0
Gpx3	12972.0	-6207.0
Gpx6	11525.0	-13876.0
Gpx7	8095.0	1337.0
Gpx8	-10057.0	10929.0
Grb10	-10947.0	9629.0
Gsk3a	3200.0	1691.0
Gsk3b	-6315.0	7700.0
Gsr	3160.0	8021.0
Gstp1	-8797.0	11786.0
H13	-10412.0	10716.0
H2afx	-3852.0	6424.0
Hba-a1	-10905.0	11866.0
Hbb-bt	-9874.0	11776.0
Hdac3	12487.0	-6122.0
Hdac6	15227.0	-14879.0
Helz2	6489.0	-6856.0
Herpud1	13130.0	-14465.0
Hif1a	12019.0	-12711.0
Hif1an	8261.0	-3428.0
Hif3a	14500.0	-13933.0
Higd1a	5410.0	-9629.0
Hira	-2684.0	4510.0
Hmga1	14417.0	-11978.0
Hmga2	4574.0	275.0
Hmox1	-10213.0	8284.0
Hmox2	-1185.0	6463.0
Hsbp1	10993.0	-11073.0
Hsf1	-9423.0	10916.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Hsp90b1	-11714.0	4358.0
Hspa12a	-11435.0	12820.0
Hspa12b	-10883.0	9748.0
Hspa13	-11554.0	7478.0
Hspa14	-10514.0	11554.0
Hspa1b	13713.0	-5345.0
Hspa1l	11534.0	-2987.0
Hspa2	14737.0	-9848.0
Hspa4	-10364.0	8604.0
Hspa4l	-11753.0	5764.0
Hspa5	-9803.0	4207.0
Hspa8	-11121.0	9278.0
Hspa9	11117.0	-6216.0
Hspb8	14294.0	-9438.0
Hsph1	-12040.0	9461.0
Hyou1	-10823.0	6660.0
Id1	-5552.0	-9376.0
Igfbp1	14640.0	-14540.0
Igfbp7	-6756.0	-9670.0
Il1a	876.5	-1222.5
Il6	-2929.0	3096.0
Impact	7475.0	-12025.0
Itfg2	10888.0	-7999.0
Jun	9574.0	-13518.0
Kat5	4420.0	6683.0
Kdelr3	12202.0	-7578.0
Kdm6b	-3039.0	-7197.0
Keap1	-9595.0	11074.0
Khsrp	-7737.0	10297.0
Klhdc3	11735.0	-10153.0
Kptn	-3141.0	-2510.0
Lamtor1	8753.0	5215.0
Lamtor2	-7753.0	1820.0
Lamtor3	11338.0	-7218.0
Lamtor4	5699.0	-11078.0
Lamtor5	13418.0	-13042.0
Limd1	-3931.0	4571.0
Lmna	5606.0	3857.0
Lmnb1	-9916.0	8126.0
Lrpprc	12946.0	-11138.0
Ly96	201.0	-8287.0
Mafk	5729.0	-6338.0
Map2k3	-11214.0	8360.0
Map2k4	9926.0	-8899.0
Map2k6	8630.0	-9645.0
Map2k7	12018.0	-8043.0
Map3k5	10364.0	-13897.0
Map4k4	-6607.0	13.0
Mapk1	6867.0	-10406.0
Mapk10	6586.0	-10216.0
Mapk11	-11176.0	11985.0
Mapk14	-12047.0	34.0
Mapk3	10588.0	-6813.0
Mapk7	-1452.0	6080.0
Mapk8	86.0	2880.0
Mapk9	12784.0	-5874.0
Mapkapk2	14192.0	-11215.0
Mapkapk3	8522.0	6234.0
Mapkapk5	41.0	3388.0
Mbtps1	-10920.0	7056.0
Mbtps2	-4990.0	8254.0
Mdm2	15095.0	-7329.0
Mdm4	-4386.0	-13416.0
Med1	-11441.0	8371.0
Mef2c	-11609.0	11809.0
Mef2d	5480.0	-13003.0
Mink1	-4422.0	8509.0
Mios	6357.0	-10601.0
Mlst8	-8191.0	9545.0
Mov10	-9876.0	4432.0
Mre11a	-5960.0	7726.0
Mrpl18	9737.0	-13625.0
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
Mtor	-12191.0	-146.0
Mydgf	-4885.0	-11322.0
Nbn	-7224.0	-4610.0
Ncf1	6928.0	1449.0
Ncf2	-10248.0	10956.0
Ncf4	-10965.0	3387.0
Ncoa1	4134.0	10315.0
Ncoa2	-8492.0	10090.0
Ncoa6	10834.0	-11817.0
Ncor1	-12619.0	12282.0
Ncor2	-9484.0	9908.0
Ndc1	13238.0	-12109.0
Ndufa4	9874.0	-14669.0
Nfe2l2	-6313.0	8709.0
Nfkb1	234.0	10216.0
Nfya	-12328.0	12716.0
Nfyb	-7061.0	7045.0
Nfyc	-3343.0	5943.0
Nlrp3	-8573.0	7411.0
Nox4	9220.0	-115.0
Npas2	-10994.0	12702.0
Nprl2	-3481.0	7578.0
Nprl3	7260.0	4129.0
Nr1d1	8240.0	12909.0
Nr3c1	-12382.0	12637.0
Nr3c2	11985.0	6542.0
Nrip1	-7563.0	-8772.0
Nudt2	-71.0	4125.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
P4hb	-11855.0	7508.0
Parn	12685.0	-10686.0
Pdia5	-12472.0	12163.0
Pdia6	-11881.0	7593.0
Pgr	-2636.0	-248.0
Phc1	-10307.0	10457.0
Phc2	9767.0	-7629.0
Phc3	-8753.0	-8471.0
Pla2g4b	-9798.0	3345.0
Pom121	9659.0	-12785.0
Pot1a	-4539.0	2798.0
Ppara	-7949.0	-13305.0
Ppargc1a	15084.0	-14366.0
Ppp1r15a	14992.0	-14845.0
Ppp2r5b	-2576.0	4479.0
Prdx1	-11307.0	7421.0
Prdx2	14368.0	-13945.0
Prdx3	14229.0	-14928.0
Prdx5	-7725.0	-5861.0
Prdx6	-4795.0	-10620.0
Preb	-11370.0	10400.0
Prkcd	11350.0	-8872.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptges3	-12133.0	6834.0
Ptk6	-8916.0	7487.0
Rad50	9654.0	-3235.0
Rae1	-2818.0	7959.0
Rai1	-9959.0	9246.0
Ranbp2	-1884.0	-9227.0
Rb1	15102.0	-13818.0
Rbbp4	-12462.0	12126.0
Rbbp7	225.0	-7926.0
Rbx1	2286.0	4532.0
Rela	7998.0	-10978.0
Rheb	-8480.0	2846.0
Ring1	-7720.0	3003.0
Rln1	-1408.0	-7998.0
Rnf2	5830.0	-10843.0
Rora	-11262.0	-14166.0
Rpa1	-5523.0	11078.0
Rpa2	6898.0	-2423.0
Rpa3	-2462.0	3353.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps19bp1	-7767.0	2134.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rptor	4891.0	6876.0
Rraga	-11375.0	9072.0
Rragb	10214.0	2103.0
Rragc	10681.0	-445.0
Rragd	15304.0	-13993.0
Rxra	78.0	-5092.0
Scmh1	7958.0	5549.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sec13	9849.0	-12486.0
Sec31a	2798.0	6168.0
Seh1l	9415.0	-7505.0
Serp1	-11616.0	8323.0
Serpinh1	-11889.0	11493.0
Sesn1	14846.0	-14730.0
Sesn2	2837.0	-13400.0
Sh3bp4	14556.0	-12878.0
Shc1	-8826.0	9471.0
Sin3a	-4457.0	256.0
Sin3b	12589.0	-8232.0
Sirt1	-6016.0	-4349.0
Skp1a	-9392.0	1413.0
Skp2	-9937.0	5846.0
Slc38a9	-7282.0	6109.0
Slc46a1	-8716.0	4783.0
Smarcd3	14278.0	-13359.0
Sod1	-11805.0	-11370.0
Sod2	5661.0	-10164.0
Sod3	4805.0	-8878.0
Sp1	-10774.0	4387.0
Srpr	10750.0	-13353.0
Srprb	3421.0	2100.0
Ssr1	-11725.0	10337.0
St13	-10189.0	-12368.0
Stap2	9402.0	-7768.0
Stat3	14430.0	-14454.0
Stip1	-11884.0	7492.0
Sult1a1	15293.0	-14966.0
Surf1	10929.0	-8571.0
Suz12	-6254.0	8020.0
Syvn1	-6510.0	240.0
Szt2	-5351.0	10104.0
Taco1	-5127.0	3445.0
Tatdn2	-8342.0	12442.0
Tbl1xr1	-8741.0	-12237.0
Tcirg1	-10070.0	11128.0
Terf1	-3395.0	-5560.0
Terf2	-15.0	-5815.0
Terf2ip	-6777.0	9210.0
Tfdp1	-7152.0	7854.0
Tfdp2	12095.0	-12073.0
Tgs1	-7102.0	2547.0
Tinf2	6319.0	-3531.0
Tln1	-11767.0	12745.0
Tlr4	-8099.0	6708.0
Tnfrsf21	10950.0	-14900.0
Tnik	-1447.0	2760.0
Tnrc6a	8288.0	-10563.0
Tnrc6b	-8828.0	9395.0
Tnrc6c	-6877.0	11145.0
Tpp1	-6752.0	5120.0
Tpr	-7568.0	-3358.0
Trib3	13141.0	-7115.0
Trp53	-7681.0	5460.0
Tspyl2	13652.0	-13954.0
Txn1	-6434.0	-12085.0
Txn2	-2645.0	-7555.0
Txnip	15044.0	-15001.0
Txnrd1	-10298.0	11671.0
Txnrd2	-978.0	-4354.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2c	9861.0	-8024.0
Ube2d1	11721.0	-13291.0
Ube2d2a	-817.0	-4700.0
Ube2d3	-7445.0	-9801.0
Ube2e1	-10811.0	7252.0
Ube2s	9693.0	-6037.0
Ubn1	-10645.0	11079.0
Vcp	-10725.0	9038.0
Vegfa	-12713.0	12720.0
Vhl	-11494.0	11676.0
Wdr24	-11111.0	12295.0
Wdr59	-5055.0	-6197.0
Wfs1	14373.0	-4859.0
Wipi1	14092.0	-14505.0
Wtip	-8752.0	8208.0
Xbp1	-12518.0	7753.0
Xpo1	-10778.0	9680.0
Yif1a	7653.0	-6960.0
Ywhae	2275.0	-8018.0
Zbtb17	4030.0	7861.0

---

---

Neuronal-System

Neuronal-System

metric	value
setSize	352
pMANOVA	6.85e-09
p.adjustMANOVA	2.67e-07
s.dist	0.124
s.diab	0.121
s.PMX	0.0233
p.diab	8.82e-05
p.PMX	0.452

Top 20 genes

Gene	diab	PMX
Ptprs	13493	10865
Hcn2	12996	11186
Nsf	12415	11174
Nefl	14459	9119
Ntrk3	13513	9712
Rps6ka1	13571	8925
Shank2	8719	11852
Homer3	11790	8687
Syn2	11332	8825
Nbea	11248	7890
Pdlim5	12012	6816
Gnb2	8485	9301
Gng4	7213	10712
Comt	12591	5841
Dbnl	9368	7787
Adcy5	5265	12483
Kcnc1	6781	9238
Prkar1b	12793	4753
Grip1	13253	4410
Kcnq1	14313	4036

Click HERE to show all gene set members

All member genes

	diab	PMX
Abat	-11455.0	10935.0
Abcc8	-2559.0	-4786.0
Abcc9	-11661.0	10701.0
Ache	14738.0	-13901.0
Actn2	13375.0	-10971.0
Adcy1	-9688.0	10111.0
Adcy2	10325.0	-11711.0
Adcy3	-9740.0	12419.0
Adcy4	-7538.0	10359.0
Adcy5	5265.0	12483.0
Adcy6	12805.0	-11480.0
Adcy7	-11420.0	12113.0
Adcy8	-5867.0	1557.0
Adcy9	-9790.0	11763.0
Akap5	13260.0	-8998.0
Aldh2	-8630.0	11396.0
Aldh5a1	-10218.0	12459.0
Ap2a1	9324.0	5186.0
Ap2a2	-8561.0	11221.0
Ap2b1	-9075.0	10334.0
Ap2m1	11298.0	-6224.0
Ap2s1	11182.0	-5073.0
Apba1	-6642.0	5916.0
Apba2	5876.0	-3319.0
Apba3	-10257.0	9151.0
Arhgef7	12872.0	-10663.0
Arhgef9	14955.0	-14756.0
Arl6ip5	11236.0	-5412.0
Bche	13959.0	-13959.0
Begain	-9988.0	9520.0
Bzrap1	12576.0	-6510.0
Cacna1a	3165.0	8312.0
Cacna1b	2503.0	-2531.5
Cacna1e	14686.0	-2514.0
Cacna2d1	-11364.0	8177.0
Cacna2d2	-2938.0	9245.0
Cacna2d3	7550.0	-9348.0
Cacnb1	-1436.0	314.0
Cacnb2	13987.0	-13437.0
Cacnb3	14958.0	-9946.0
Cacnb4	13292.0	-8106.0
Cacng2	6764.0	-8034.0
Cacng4	-7699.0	10544.0
Cacng8	6407.0	5725.0
Calm1	152.0	-11443.0
Camk1	12879.0	-10977.0
Camk2a	-8582.0	9297.0
Camk2b	12864.0	-14402.0
Camk2d	14624.0	-13868.0
Camk2g	-9180.0	8979.0
Camk4	5035.0	6029.0
Camkk1	-1546.0	8538.0
Camkk2	8901.0	1669.0
Cask	13958.0	-14155.0
Chrna2	-6209.0	11280.0
Chrna4	-9583.0	12086.0
Chrna5	6554.0	2110.0
Chrna6	1803.5	-2073.5
Chrna7	-3180.0	10054.0
Chrnb2	14415.0	-14332.0
Chrnb3	3735.0	-3929.0
Chrnb4	10785.0	-12957.0
Chrne	-7475.0	6659.0
Chrng	876.5	-1222.5
Comt	12591.0	5841.0
Cplx1	8125.0	-4389.0
Creb1	-10512.0	8785.0
Dbnl	9368.0	7787.0
Dlg1	12024.0	-11729.0
Dlg2	-8800.0	12793.0
Dlg3	9912.0	3835.0
Dlg4	-7223.0	10585.0
Dlgap1	9250.0	-13093.0
Dlgap2	876.5	-1222.5
Dlgap3	10923.0	-10767.0
Dlgap4	13664.0	-488.0
Dnajc5	13469.0	-12334.0
Epb41	12753.0	-11885.0
Epb41l1	-7182.0	11483.0
Epb41l2	9607.0	-111.0
Epb41l3	14899.0	-9419.0
Epb41l5	12355.0	-14191.0
Erbb4	11714.0	-13547.0
Flot1	14308.0	-13529.0
Flot2	13212.0	-12960.0
Gabbr1	-3768.0	-11101.0
Gabbr2	-8446.0	4308.0
Gabra3	3418.0	-375.0
Gabra4	7284.0	4892.0
Gabra5	5264.0	1822.0
Gabrb1	6754.0	5915.0
Gabrb2	3982.0	1487.5
Gabrb3	-11829.0	12435.0
Gabrg3	-9268.0	10340.0
Gabrq	-5274.0	5506.0
Gabrr1	876.5	-1222.5
Gabrr2	-11356.0	10603.0
Gad1	-3035.0	-4672.0
Gad2	-7452.0	-3853.0
Git1	13031.0	-6200.0
Gja10	876.5	951.0
Gjc1	-2996.0	8487.0
Glra3	3527.5	-3689.5
Glrb	3153.5	-5569.5
Gls	13744.0	-14134.0
Gls2	5942.0	60.0
Glul	14333.0	-14998.0
Gnai1	-3956.0	-10186.0
Gnai2	11179.0	-2885.0
Gnai3	-262.0	-10393.0
Gnal	12958.0	-10540.0
Gnb1	14052.0	-12910.0
Gnb2	8485.0	9301.0
Gnb3	-2490.5	742.0
Gnb4	-1201.0	-6056.0
Gnb5	13333.0	-11130.0
Gng10	2409.0	6218.0
Gng11	-3886.0	7951.0
Gng12	6244.0	-14594.0
Gng2	10797.0	-7497.0
Gng3	-4926.0	7095.0
Gng4	7213.0	10712.0
Gng5	4656.0	-12487.0
Gng7	-3080.0	9870.0
Gng8	-4369.0	8851.0
Gngt1	1803.5	-1222.5
Gngt2	-1659.0	-5045.0
Gria1	10686.0	-11418.0
Gria2	-839.5	-1222.5
Gria3	13794.0	-4475.0
Gria4	11664.0	-11066.0
Grik2	148.0	-10920.5
Grik3	-3277.0	3630.0
Grik4	2298.0	-6760.0
Grik5	12458.0	153.0
Grin1	8164.0	3365.0
Grin2a	8133.0	-4772.0
Grin2b	7538.0	-7715.0
Grin2c	-8070.0	8860.0
Grin2d	4321.0	-10284.0
Grin3a	-10410.0	11126.0
Grin3b	-11710.0	11922.0
Grip1	13253.0	4410.0
Grip2	-10323.0	8930.0
Grm5	876.5	481.0
Hcn2	12996.0	11186.0
Hcn3	-1827.0	6938.0
Hcn4	7558.0	1890.0
Homer1	-10082.0	2026.0
Homer2	-273.0	-13018.0
Homer3	11790.0	8687.0
Hras	12615.0	-11955.0
Hspa8	-11121.0	9278.0
Htr3a	-9474.0	11749.0
Htr3b	3982.0	-4180.0
Il1rap	-938.0	-5891.0
Il1rapl1	9175.0	230.0
Kcna1	8479.0	-5885.0
Kcna2	8606.0	-4273.0
Kcna3	3037.0	7618.0
Kcna5	7113.0	7211.0
Kcna6	-5874.0	6730.0
Kcna7	4838.0	-6827.0
Kcnab1	13801.0	-4501.0
Kcnab2	-9270.0	10256.0
Kcnab3	10564.0	-10850.0
Kcnb1	14824.0	-13638.0
Kcnb2	-6858.0	5011.0
Kcnc1	6781.0	9238.0
Kcnc2	12071.0	-15002.0
Kcnc3	-4276.0	-9008.0
Kcnc4	14243.0	-11542.0
Kcnd1	11410.0	-8402.0
Kcnd2	2807.0	-8033.0
Kcnd3	-11901.0	12687.0
Kcnf1	4313.0	3158.0
Kcng1	-9926.0	6243.0
Kcng2	-4691.0	10671.0
Kcng3	12675.0	-10378.0
Kcng4	12574.0	-11691.0
Kcnh1	-7734.0	3431.0
Kcnh2	-3909.0	8975.0
Kcnh3	6604.0	-7088.0
Kcnh4	2652.0	-4150.5
Kcnh5	-2359.0	-9027.0
Kcnh6	-7541.0	-7377.0
Kcnh7	3134.0	-7417.0
Kcnh8	10602.0	-11372.0
Kcnj1	13046.0	-8435.0
Kcnj10	10122.0	-6111.0
Kcnj11	-406.0	8525.0
Kcnj12	-8306.0	12015.0
Kcnj14	6573.0	2105.0
Kcnj15	-9626.0	-11740.0
Kcnj16	-2876.0	-12755.0
Kcnj2	-11166.0	-4368.0
Kcnj3	7261.0	-3635.0
Kcnj4	6321.0	-9730.0
Kcnj5	7020.0	4708.0
Kcnj6	876.5	-1222.5
Kcnj8	-9312.0	9122.0
Kcnj9	-6836.0	11373.0
Kcnk1	14521.0	-15029.0
Kcnk10	7153.5	-7676.5
Kcnk13	5538.0	3434.0
Kcnk2	-1377.0	10948.0
Kcnk3	174.0	8105.0
Kcnk4	2643.5	1390.0
Kcnk6	-8761.0	7090.0
Kcnk7	5850.0	-6155.0
Kcnma1	4311.0	-9359.0
Kcnmb1	5070.0	-438.0
Kcnmb2	-7370.0	-65.0
Kcnmb3	-5990.0	-2763.5
Kcnmb4	5944.0	5910.0
Kcnn1	-7704.0	12100.0
Kcnn2	10110.0	-6948.0
Kcnn3	12853.0	-9480.0
Kcnn4	-10111.0	12061.0
Kcnq1	14313.0	4036.0
Kcnq2	2579.0	-4106.0
Kcnq3	-9922.0	-7422.0
Kcnq4	-4469.0	9403.0
Kcnq5	-3285.0	7582.0
Kcns1	4609.0	7642.0
Kcns3	10689.0	-6045.0
Kif17	7565.0	-426.0
Kpna2	-6529.0	3386.0
Kras	8243.0	-12396.0
Lin7a	-12341.0	7926.0
Lin7b	8739.0	3638.0
Lin7c	-616.0	-14468.0
Lrfn1	-4754.0	7327.0
Lrfn2	-1358.0	6478.0
Lrfn3	13845.0	1905.0
Lrfn4	-5890.0	3882.0
Lrrc4b	876.5	-1222.5
Lrrc7	12248.0	-12822.0
Lrrtm1	6738.0	-8682.0
Lrrtm2	-1914.0	1714.0
Lrrtm3	-3562.0	5140.0
Maoa	15138.0	-15120.0
Mapk1	6867.0	-10406.0
Mapk3	10588.0	-6813.0
Mapt	-11830.0	11877.0
Mdm2	15095.0	-7329.0
Myo6	-10238.0	3818.0
Naaa	-10127.0	11439.0
Nbea	11248.0	7890.0
Ncald	7241.0	-7160.0
Nefl	14459.0	9119.0
Nlgn1	8391.0	3604.0
Nlgn2	12317.0	-4651.0
Nlgn3	3176.0	4899.0
Nptn	7462.0	-10591.0
Nras	11707.0	-12390.0
Nrg1	7244.0	7473.0
Nrgn	5447.0	-11536.0
Nrxn1	-5829.0	-4990.0
Nrxn2	-9771.0	9691.0
Nrxn3	-9466.0	6908.0
Nsf	12415.0	11174.0
Ntrk3	13513.0	9712.0
Panx1	6044.0	7893.0
Panx2	-3182.0	-3122.0
Pdlim5	12012.0	6816.0
Pdpk1	11828.0	-12301.0
Pick1	8170.0	-2819.0
Plcb1	-7289.0	1115.0
Plcb2	-11254.0	12407.0
Plcb3	-10411.0	12326.0
Ppfia1	3226.0	-370.0
Ppfia2	7442.0	-6570.0
Ppfia3	12917.0	-9585.0
Ppfia4	11704.0	-9559.0
Ppfibp1	14939.0	-13505.0
Ppfibp2	10135.0	-3276.0
Ppm1e	-10186.0	11097.0
Ppm1f	-3708.0	9683.0
Prkaa1	-3960.0	-4791.0
Prkaa2	-10700.0	7488.0
Prkab1	12403.0	-8117.0
Prkab2	-7030.0	7551.0
Prkaca	-8030.0	10329.0
Prkacb	-256.0	3728.0
Prkag1	2452.0	5043.0
Prkag2	13805.0	-7.0
Prkag3	13457.0	-10380.0
Prkar1a	12224.0	-10675.0
Prkar1b	12793.0	4753.0
Prkar2a	13537.0	-12751.0
Prkar2b	-11024.0	2146.0
Prkca	-11577.0	11021.0
Prkcb	-7742.0	7077.0
Prkcg	-3971.0	-8866.0
Prkx	11803.0	-4364.0
Ptprd	13650.0	-14320.0
Ptprf	11082.0	2602.0
Ptprs	13493.0	10865.0
Rab3a	8660.0	-4382.0
Rac1	-4047.0	262.0
Rasgrf1	-3720.0	-5138.0
Rasgrf2	9870.0	-9198.0
Rims1	-2531.0	-1222.5
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Rps6ka6	-2720.0	-6681.0
Rtn3	10049.0	-14485.0
Shank1	12242.0	-13481.0
Shank2	8719.0	11852.0
Shank3	-8064.0	11859.0
Sharpin	11857.0	-478.0
Sipa1l1	-12615.0	12866.0
Slc17a7	7796.0	-2453.0
Slc18a2	6956.0	4529.0
Slc1a1	-11293.0	11806.0
Slc1a2	-12370.0	11787.0
Slc1a3	12738.0	-9096.0
Slc1a6	3402.0	-9908.0
Slc1a7	4374.0	-8891.0
Slc22a1	5036.0	4679.0
Slc22a2	-12013.0	9585.0
Slc38a1	13424.0	-11911.0
Slc38a2	13304.0	-14762.0
Slc6a11	1803.5	-2073.5
Slc6a12	15137.0	-15079.0
Slc6a13	14786.0	-15051.0
Slc6a3	2383.5	1282.0
Slc6a4	-5929.0	-9001.0
Slitrk1	-5678.0	10547.0
Slitrk2	5962.5	-5217.0
Slitrk3	876.5	-1222.5
Slitrk4	15046.0	-11118.0
Slitrk5	6221.0	4519.0
Slitrk6	-12733.0	7574.0
Snap25	5976.5	-6281.0
Src	8646.0	4243.0
Stx1a	5988.0	1092.0
Stxbp1	10299.0	3684.0
Syn1	-5168.0	9023.0
Syn2	11332.0	8825.0
Syn3	-6151.0	5952.0
Syt1	-7577.0	-3184.0
Syt12	-11717.0	8911.0
Syt2	13060.0	-12222.0
Syt7	-2404.0	12602.0
Syt9	11532.0	-5895.0
Tomt	6039.0	-6503.0
Tspan7	14518.0	-13734.0
Unc13b	15045.0	-13336.0
Vamp2	10726.0	-10983.0

---

---

Cellular-responses-to-stimuli

Cellular-responses-to-stimuli

metric	value
setSize	639
pMANOVA	8.37e-09
p.adjustMANOVA	3.18e-07
s.dist	0.166
s.diab	0.0891
s.PMX	-0.141
p.diab	0.000114
p.PMX	1.17e-09

Top 20 genes

Gene	diab	PMX
Cebpb	15167	-15133
Sult1a1	15293	-14966
Rplp1	15259	-14929
Cox6b1	15253	-14902
Rpl32	15195	-14957
Rps11	15181	-14944
Cox6c	15087	-15036
Hdac6	15227	-14879
Txnip	15044	-15001
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Atp6v0e	14931	-14952
Ppp1r15a	14992	-14845
Cox5a	15090	-14747
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
Aaas	13184.0	10673.0
Acadvl	8255.0	-13764.0
Acd	-4896.0	9107.0
Actr10	8979.0	4659.0
Actr1a	10383.0	-8216.0
Add1	-10711.0	8903.0
Ago1	13694.0	-4416.0
Ago3	-10688.0	9354.0
Ago4	4723.0	6013.0
Ajuba	-11055.0	10965.0
Akt1s1	9188.0	-3366.0
Alb	-5186.0	-12238.0
Anapc1	-11278.0	10450.0
Anapc10	-40.0	-7692.0
Anapc11	-4767.0	-2276.0
Anapc15	-2513.0	-9553.0
Anapc16	13128.0	-13447.0
Anapc2	-3217.0	9388.0
Anapc4	14276.0	-12248.0
Anapc5	14536.0	-12088.0
Anapc7	10824.0	-6183.0
Apoa1	-4915.0	-14116.0
Apob	14399.0	-9778.0
Aqp8	13473.0	8867.0
Ar	2881.0	-13790.0
Arfgap1	7144.0	-11530.0
Arnt	7604.0	-12300.0
Arntl	-3021.0	9713.0
Asf1a	-6271.0	-233.0
Asns	14974.0	-13140.0
Atf2	-6723.0	3300.0
Atf3	5940.0	-10511.0
Atf4	10850.0	-13249.0
Atf5	15204.0	-14291.0
Atf6	-5207.0	-11001.0
Atm	11462.0	2585.0
Atox1	15063.0	-14006.0
Atp6v0b	4840.0	2125.0
Atp6v0c	3151.0	-10611.0
Atp6v0d1	203.0	1912.0
Atp6v0d2	15150.0	-3904.0
Atp6v0e	14931.0	-14952.0
Atp6v0e2	7872.0	6422.0
Atp6v1a	10227.0	-7433.0
Atp6v1b1	13172.0	12006.0
Atp6v1b2	-7304.0	5553.0
Atp6v1c1	12161.0	-10561.0
Atp6v1c2	14305.0	9508.0
Atp6v1d	12172.0	-14697.0
Atp6v1e1	13351.0	-11187.0
Atp6v1f	14121.0	-13473.0
Atp6v1g1	15089.0	-12782.0
Atp6v1g2	-3055.0	4701.0
Atp6v1g3	14162.0	-9021.0
Atp6v1h	9566.0	-8530.0
Atp7a	14760.0	-13906.0
Atr	4265.0	-9369.0
Bach1	-166.0	-14122.0
Bag1	15011.0	-14578.0
Bag2	14764.0	-14917.0
Bag3	6958.0	-3130.0
Bag4	14606.0	-13789.0
Bag5	-8551.0	7728.0
BC048403	8126.0	-4500.0
Blvra	14254.0	-15053.0
Blvrb	-9559.0	9965.0
Bmi1	-6546.0	9252.0
Cabin1	-3241.0	8514.0
Calr	-12155.0	11400.0
Camk2a	-8582.0	9297.0
Camk2b	12864.0	-14402.0
Camk2d	14624.0	-13868.0
Camk2g	-9180.0	8979.0
Capza2	9159.0	-12805.0
Capzb	4505.0	8343.0
Car9	-10836.0	5039.0
Carm1	8621.0	-6979.0
Cat	-10493.0	8958.0
Cbx2	-6995.0	8685.0
Cbx4	-12196.0	11468.0
Cbx6	-6489.0	12600.0
Cbx8	-11721.0	11385.0
Ccar2	-4891.0	11765.0
Ccna2	12043.0	-6678.0
Ccne1	8507.0	-10924.0
Ccne2	4837.0	-11061.0
Ccs	10222.0	-7052.0
Cdc16	10625.0	-286.0
Cdc23	180.0	8382.0
Cdc26	8205.0	-5823.0
Cdc27	-6730.0	-6274.0
Cdk2	12902.0	-12285.0
Cdk4	7497.0	6438.0
Cdk6	-8022.0	-8784.0
Cdkn1a	15394.0	-12557.0
Cdkn1b	4380.0	258.0
Cdkn2b	14383.0	-14293.0
Cdkn2c	-1158.0	9132.0
Cdkn2d	5293.0	2129.0
Cebpb	15167.0	-15133.0
Cebpg	-7894.0	-8449.0
Chac1	9497.0	-11449.0
Chd9	-8520.0	9935.0
Cited2	13876.0	-12832.0
Clec1b	11098.0	-12765.0
Clock	13462.0	-8810.0
Col4a6	11959.0	-9813.0
Cox11	-5668.0	4904.0
Cox14	-1686.0	-7203.0
Cox16	-7714.0	16.0
Cox18	-7936.0	6577.0
Cox19	5012.0	7838.0
Cox20	-9998.0	-3483.0
Cox4i1	14109.0	-13335.0
Cox5a	15090.0	-14747.0
Cox6a1	13803.0	-14212.0
Cox6b1	15253.0	-14902.0
Cox6c	15087.0	-15036.0
Cox7a2l	-3085.0	-11539.0
Cox7c	14740.0	-14896.0
Cox8a	14173.0	-14806.0
Creb1	-10512.0	8785.0
Creb3	9940.0	-6204.0
Creb3l1	-11315.0	9056.0
Creb3l2	-11326.0	12802.0
Creb3l3	2849.0	-10313.0
Creb3l4	10042.0	-10791.0
Crebbp	7115.0	-7498.0
Crebrf	12563.0	-14625.0
Crtc1	-5952.0	10621.0
Crtc2	8982.0	-6795.0
Crtc3	-6336.0	2634.0
Cryab	14126.0	-15076.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Csrp1	3461.0	7979.0
Ctdsp2	9633.0	-12180.0
Cul1	114.0	-11623.0
Cul2	-7656.0	2073.0
Cul3	-5498.0	5923.0
Cul7	15078.0	7816.0
Cxxc1	-5408.0	9554.0
Cyba	-11001.0	9452.0
Cybb	-3640.0	4621.0
Cycs	8402.0	-13138.0
Dcp2	-11008.0	5190.0
Dcstamp	-1104.0	-3929.0
Dctn1	4613.0	8656.0
Dctn2	13574.0	-8129.0
Dctn3	13985.0	-13682.0
Dctn4	12982.0	-11645.0
Dctn5	-8689.0	10997.0
Dctn6	14486.0	-12682.0
Ddit3	13910.0	-13026.0
Ddx11	7225.0	-10933.0
Dedd2	14645.0	-11044.0
Depdc5	10603.0	-12516.0
Dis3	-10317.0	11084.0
Dnaja1	-12236.0	9878.0
Dnaja2	-5772.0	-8172.0
Dnaja4	-11188.0	7938.0
Dnajb1	-6536.0	7870.0
Dnajb11	-9969.0	6273.0
Dnajb6	-10294.0	-12881.0
Dnajb9	12791.0	-14995.0
Dnajc2	-8664.0	11294.0
Dnajc3	-9188.0	-13392.0
Dnajc7	12107.0	-10594.0
Dync1h1	12037.0	3704.0
Dync1i1	7564.0	7503.0
Dync1i2	13930.0	-14334.0
Dync1li1	10870.0	-10085.0
Dync1li2	13775.0	-14349.0
Dynll1	-10023.0	-2241.0
Dynll2	-12351.0	10871.0
E2f1	14773.0	-13127.0
E2f2	-10922.0	8773.0
E2f3	9873.0	3869.0
Edem1	-12574.0	11731.0
Eed	-9201.0	7028.0
Eef1a1	6403.0	-13665.0
Egln1	-12506.0	12895.0
Egln2	-5176.0	1141.0
Egln3	11444.0	-14851.0
Ehmt1	-4418.0	-10516.0
Ehmt2	4354.0	10437.0
Eif2ak1	3385.0	-5086.0
Eif2ak3	13308.0	-14103.0
Eif2ak4	12662.0	-12468.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Ep300	-10091.0	9600.0
Ep400	-6397.0	9291.0
Epas1	-10492.0	12228.0
Epo	12444.0	-7846.0
Erf	-4112.0	-11941.0
Ern1	-7176.0	10149.0
Ero1l	13872.0	-14020.0
Ets1	-12235.0	12571.0
Ets2	-11047.0	10868.0
Exosc1	-1652.0	-259.0
Exosc2	-4051.0	7454.0
Exosc3	-9773.0	11565.0
Exosc4	-6162.0	8972.0
Exosc5	-4859.0	4528.0
Exosc7	12464.0	-11384.0
Exosc8	-4592.0	-5642.0
Exosc9	14145.0	-12668.0
Extl1	14857.0	-13844.0
Extl2	13675.0	-4705.0
Extl3	-5757.0	11997.0
Ezh2	13058.0	-14025.0
Fabp1	13947.0	-14420.0
Fbxl17	-5253.0	9551.0
Fkbp14	14595.0	-13859.0
Fkbp4	-12401.0	11088.0
Fkbp5	8456.0	-14207.0
Flcn	8427.0	2620.0
Flt3l	-10231.0	11283.0
Fnip1	5376.0	-14121.0
Fnip2	6241.0	-11575.0
Fos	5077.0	22.0
Fzr1	-2715.0	9851.0
Gatsl2	10871.0	-9194.0
Gatsl3	-1475.0	8414.0
Gcn1l1	-8991.0	12087.0
Gfpt1	10435.0	-14180.0
Gm10263	6260.5	-6620.0
Gm11273	8317.0	-6691.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gml	2512.5	-2558.5
Gosr2	5078.0	3020.0
Gpx1	-3900.0	5605.0
Gpx3	12972.0	-6207.0
Gpx6	11525.0	-13876.0
Gpx7	8095.0	1337.0
Gpx8	-10057.0	10929.0
Grb10	-10947.0	9629.0
Gsk3a	3200.0	1691.0
Gsk3b	-6315.0	7700.0
Gsr	3160.0	8021.0
Gstp1	-8797.0	11786.0
H13	-10412.0	10716.0
H2afx	-3852.0	6424.0
Hba-a1	-10905.0	11866.0
Hbb-bt	-9874.0	11776.0
Hdac3	12487.0	-6122.0
Hdac6	15227.0	-14879.0
Helz2	6489.0	-6856.0
Herpud1	13130.0	-14465.0
Hif1a	12019.0	-12711.0
Hif1an	8261.0	-3428.0
Hif3a	14500.0	-13933.0
Higd1a	5410.0	-9629.0
Hira	-2684.0	4510.0
Hmga1	14417.0	-11978.0
Hmga2	4574.0	275.0
Hmox1	-10213.0	8284.0
Hmox2	-1185.0	6463.0
Hsbp1	10993.0	-11073.0
Hsf1	-9423.0	10916.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Hsp90b1	-11714.0	4358.0
Hspa12a	-11435.0	12820.0
Hspa12b	-10883.0	9748.0
Hspa13	-11554.0	7478.0
Hspa14	-10514.0	11554.0
Hspa1b	13713.0	-5345.0
Hspa1l	11534.0	-2987.0
Hspa2	14737.0	-9848.0
Hspa4	-10364.0	8604.0
Hspa4l	-11753.0	5764.0
Hspa5	-9803.0	4207.0
Hspa8	-11121.0	9278.0
Hspa9	11117.0	-6216.0
Hspb8	14294.0	-9438.0
Hsph1	-12040.0	9461.0
Hyou1	-10823.0	6660.0
Id1	-5552.0	-9376.0
Igfbp1	14640.0	-14540.0
Igfbp7	-6756.0	-9670.0
Il1a	876.5	-1222.5
Il6	-2929.0	3096.0
Impact	7475.0	-12025.0
Itfg2	10888.0	-7999.0
Jun	9574.0	-13518.0
Kat5	4420.0	6683.0
Kdelr3	12202.0	-7578.0
Kdm6b	-3039.0	-7197.0
Keap1	-9595.0	11074.0
Khsrp	-7737.0	10297.0
Klhdc3	11735.0	-10153.0
Kptn	-3141.0	-2510.0
Lamtor1	8753.0	5215.0
Lamtor2	-7753.0	1820.0
Lamtor3	11338.0	-7218.0
Lamtor4	5699.0	-11078.0
Lamtor5	13418.0	-13042.0
Limd1	-3931.0	4571.0
Lmna	5606.0	3857.0
Lmnb1	-9916.0	8126.0
Lrpprc	12946.0	-11138.0
Ly96	201.0	-8287.0
Mafk	5729.0	-6338.0
Map2k3	-11214.0	8360.0
Map2k4	9926.0	-8899.0
Map2k6	8630.0	-9645.0
Map2k7	12018.0	-8043.0
Map3k5	10364.0	-13897.0
Map4k4	-6607.0	13.0
Mapk1	6867.0	-10406.0
Mapk10	6586.0	-10216.0
Mapk11	-11176.0	11985.0
Mapk14	-12047.0	34.0
Mapk3	10588.0	-6813.0
Mapk7	-1452.0	6080.0
Mapk8	86.0	2880.0
Mapk9	12784.0	-5874.0
Mapkapk2	14192.0	-11215.0
Mapkapk3	8522.0	6234.0
Mapkapk5	41.0	3388.0
Mbtps1	-10920.0	7056.0
Mbtps2	-4990.0	8254.0
Mdm2	15095.0	-7329.0
Mdm4	-4386.0	-13416.0
Med1	-11441.0	8371.0
Mef2c	-11609.0	11809.0
Mef2d	5480.0	-13003.0
Mink1	-4422.0	8509.0
Mios	6357.0	-10601.0
Mlst8	-8191.0	9545.0
Mov10	-9876.0	4432.0
Mre11a	-5960.0	7726.0
Mrpl18	9737.0	-13625.0
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
Mt2	12724.0	-15092.0
Mt3	-7832.0	8039.0
Mtf1	-10197.0	7759.0
Mtor	-12191.0	-146.0
Mydgf	-4885.0	-11322.0
Nbn	-7224.0	-4610.0
Ncf1	6928.0	1449.0
Ncf2	-10248.0	10956.0
Ncf4	-10965.0	3387.0
Ncoa1	4134.0	10315.0
Ncoa2	-8492.0	10090.0
Ncoa6	10834.0	-11817.0
Ncor1	-12619.0	12282.0
Ncor2	-9484.0	9908.0
Ndc1	13238.0	-12109.0
Ndufa4	9874.0	-14669.0
Nfe2l2	-6313.0	8709.0
Nfkb1	234.0	10216.0
Nfya	-12328.0	12716.0
Nfyb	-7061.0	7045.0
Nfyc	-3343.0	5943.0
Nlrp3	-8573.0	7411.0
Nox4	9220.0	-115.0
Npas2	-10994.0	12702.0
Nprl2	-3481.0	7578.0
Nprl3	7260.0	4129.0
Nr1d1	8240.0	12909.0
Nr3c1	-12382.0	12637.0
Nr3c2	11985.0	6542.0
Nrip1	-7563.0	-8772.0
Nudt2	-71.0	4125.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
P4hb	-11855.0	7508.0
Parn	12685.0	-10686.0
Pdia5	-12472.0	12163.0
Pdia6	-11881.0	7593.0
Pgr	-2636.0	-248.0
Phc1	-10307.0	10457.0
Phc2	9767.0	-7629.0
Phc3	-8753.0	-8471.0
Pla2g4b	-9798.0	3345.0
Pom121	9659.0	-12785.0
Pot1a	-4539.0	2798.0
Ppara	-7949.0	-13305.0
Ppargc1a	15084.0	-14366.0
Ppp1r15a	14992.0	-14845.0
Ppp2r5b	-2576.0	4479.0
Prdx1	-11307.0	7421.0
Prdx2	14368.0	-13945.0
Prdx3	14229.0	-14928.0
Prdx5	-7725.0	-5861.0
Prdx6	-4795.0	-10620.0
Preb	-11370.0	10400.0
Prkcd	11350.0	-8872.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptges3	-12133.0	6834.0
Ptk6	-8916.0	7487.0
Rad50	9654.0	-3235.0
Rae1	-2818.0	7959.0
Rai1	-9959.0	9246.0
Ranbp2	-1884.0	-9227.0
Rb1	15102.0	-13818.0
Rbbp4	-12462.0	12126.0
Rbbp7	225.0	-7926.0
Rbx1	2286.0	4532.0
Rela	7998.0	-10978.0
Rheb	-8480.0	2846.0
Ring1	-7720.0	3003.0
Rln1	-1408.0	-7998.0
Rnf2	5830.0	-10843.0
Rora	-11262.0	-14166.0
Rpa1	-5523.0	11078.0
Rpa2	6898.0	-2423.0
Rpa3	-2462.0	3353.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps19bp1	-7767.0	2134.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rptor	4891.0	6876.0
Rraga	-11375.0	9072.0
Rragb	10214.0	2103.0
Rragc	10681.0	-445.0
Rragd	15304.0	-13993.0
Rxra	78.0	-5092.0
Scmh1	7958.0	5549.0
Sco1	-6972.0	8974.0
Sco2	-333.0	4973.0
Sec13	9849.0	-12486.0
Sec31a	2798.0	6168.0
Seh1l	9415.0	-7505.0
Serp1	-11616.0	8323.0
Serpinh1	-11889.0	11493.0
Sesn1	14846.0	-14730.0
Sesn2	2837.0	-13400.0
Sh3bp4	14556.0	-12878.0
Shc1	-8826.0	9471.0
Sin3a	-4457.0	256.0
Sin3b	12589.0	-8232.0
Sirt1	-6016.0	-4349.0
Skp1a	-9392.0	1413.0
Skp2	-9937.0	5846.0
Slc38a9	-7282.0	6109.0
Slc46a1	-8716.0	4783.0
Smarcd3	14278.0	-13359.0
Sod1	-11805.0	-11370.0
Sod2	5661.0	-10164.0
Sod3	4805.0	-8878.0
Sp1	-10774.0	4387.0
Srpr	10750.0	-13353.0
Srprb	3421.0	2100.0
Ssr1	-11725.0	10337.0
St13	-10189.0	-12368.0
Stap2	9402.0	-7768.0
Stat3	14430.0	-14454.0
Stip1	-11884.0	7492.0
Sult1a1	15293.0	-14966.0
Surf1	10929.0	-8571.0
Suz12	-6254.0	8020.0
Syvn1	-6510.0	240.0
Szt2	-5351.0	10104.0
Taco1	-5127.0	3445.0
Tatdn2	-8342.0	12442.0
Tbl1xr1	-8741.0	-12237.0
Tcirg1	-10070.0	11128.0
Terf1	-3395.0	-5560.0
Terf2	-15.0	-5815.0
Terf2ip	-6777.0	9210.0
Tfdp1	-7152.0	7854.0
Tfdp2	12095.0	-12073.0
Tgs1	-7102.0	2547.0
Tinf2	6319.0	-3531.0
Tln1	-11767.0	12745.0
Tlr4	-8099.0	6708.0
Tnfrsf21	10950.0	-14900.0
Tnik	-1447.0	2760.0
Tnrc6a	8288.0	-10563.0
Tnrc6b	-8828.0	9395.0
Tnrc6c	-6877.0	11145.0
Tpp1	-6752.0	5120.0
Tpr	-7568.0	-3358.0
Trib3	13141.0	-7115.0
Trp53	-7681.0	5460.0
Tspyl2	13652.0	-13954.0
Txn1	-6434.0	-12085.0
Txn2	-2645.0	-7555.0
Txnip	15044.0	-15001.0
Txnrd1	-10298.0	11671.0
Txnrd2	-978.0	-4354.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Ube2c	9861.0	-8024.0
Ube2d1	11721.0	-13291.0
Ube2d2a	-817.0	-4700.0
Ube2d3	-7445.0	-9801.0
Ube2e1	-10811.0	7252.0
Ube2s	9693.0	-6037.0
Ubn1	-10645.0	11079.0
Vcp	-10725.0	9038.0
Vegfa	-12713.0	12720.0
Vhl	-11494.0	11676.0
Wdr24	-11111.0	12295.0
Wdr59	-5055.0	-6197.0
Wfs1	14373.0	-4859.0
Wipi1	14092.0	-14505.0
Wtip	-8752.0	8208.0
Xbp1	-12518.0	7753.0
Xpo1	-10778.0	9680.0
Yif1a	7653.0	-6960.0
Ywhae	2275.0	-8018.0
Zbtb17	4030.0	7861.0

---

---

Gluconeogenesis

Gluconeogenesis

metric	value
setSize	30
pMANOVA	1.22e-08
p.adjustMANOVA	4.53e-07
s.dist	0.824
s.diab	0.6
s.PMX	-0.565
p.diab	1.25e-08
p.PMX	8.28e-08

Top 20 genes

Gene	diab	PMX
Aldoc	15389	-15147
Mdh1	15344	-15111
Eno1	15346	-14918
Aldob	15112	-15035
Pck1	15049	-15032
Got1	15126	-14433
Fbp2	15221	-14331
Slc37a4	14589	-14261
Pgk1	14769	-14051
Gpi1	14553	-14068
Fbp1	14971	-13560
Pgam1	14351	-13615
Mdh2	14022	-13258
Got2	14120	-12201
Eno2	11792	-13834
Eno3	12251	-12638
Slc37a1	13012	-11840
Slc25a12	15159	-10019
Slc25a11	12566	-9400
Tpi1	12212	-9334

Click HERE to show all gene set members

All member genes

	diab	PMX
Aldoart2	-2897.5	617.5
Aldob	15112.0	-15035.0
Aldoc	15389.0	-15147.0
Eno1	15346.0	-14918.0
Eno2	11792.0	-13834.0
Eno3	12251.0	-12638.0
Fbp1	14971.0	-13560.0
Fbp2	15221.0	-14331.0
G6pc2	6368.0	-5830.0
G6pc3	-3265.0	-265.0
Got1	15126.0	-14433.0
Got2	14120.0	-12201.0
Gpi1	14553.0	-14068.0
Mdh1	15344.0	-15111.0
Mdh2	14022.0	-13258.0
Pck1	15049.0	-15032.0
Pck2	12500.0	2592.0
Pcx	-10992.0	8150.0
Pgam1	14351.0	-13615.0
Pgam2	10491.0	12436.0
Pgk1	14769.0	-14051.0
Slc25a1	7798.0	-8481.0
Slc25a10	4794.0	-10546.0
Slc25a11	12566.0	-9400.0
Slc25a12	15159.0	-10019.0
Slc25a13	-8801.0	-10830.0
Slc37a1	13012.0	-11840.0
Slc37a2	-8352.0	7658.0
Slc37a4	14589.0	-14261.0
Tpi1	12212.0	-9334.0

---

---

Metabolism-of-RNA

Metabolism-of-RNA

metric	value
setSize	646
pMANOVA	3.6e-08
p.adjustMANOVA	1.3e-06
s.dist	0.128
s.diab	0.0409
s.PMX	-0.121
p.diab	0.0752
p.PMX	1.26e-07

Top 20 genes

Gene	diab	PMX
Rplp1	15259	-14929
Rpl32	15195	-14957
Hnrnpa1	15139	-15011
Rps11	15181	-14944
Utp20	15103	-15017
Rps17	14996	-14975
Nop10	14932	-15027
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Rpl23	14658	-14919
Rps23	14881	-14689
Rpl37	14582	-14962
Rps21	14839	-14698
Rpl26	14694	-14843

Click HERE to show all gene set members

All member genes

	diab	PMX
1700123L14Rik	-2109.5	2317.5
A1cf	-8553.0	-10993.0
Aaas	13184.0	10673.0
Actb	-6959.0	10268.0
Adar	9449.0	-298.0
Adarb1	10878.0	-7891.0
Adat1	-7286.0	-3140.0
Adat2	4698.0	-145.0
Adat3	-7018.0	6033.0
AI597479	-5493.0	-3594.0
Akt1	11899.0	-4407.0
Alkbh8	-6311.0	4896.0
Alyref	10411.0	-5688.0
Anp32a	13795.0	-12263.0
Apobec1	-5746.0	-7769.0
Apobec2	9871.0	-13630.0
Apobec3	13488.0	-13295.0
Apobec4	876.5	-1222.5
Aqr	-5230.0	7797.0
Bcas2	-4916.0	6737.0
Bms1	7917.0	-7605.0
Bmyc	6106.0	3479.0
Bop1	-8108.0	8532.0
Bud31	-1148.0	-8407.0
Bysl	-5612.0	9140.0
C1d	-6714.0	-2249.0
Casc3	-213.0	8374.0
Ccar1	-8428.0	9865.0
Ccnh	-9565.0	9010.0
Cd2bp2	10043.0	1670.0
Cd44	-11921.0	11492.0
Cdc40	10047.0	-12699.0
Cdc5l	-8772.0	10851.0
Cdk7	-6948.0	4688.0
Cdkal1	13995.0	-13829.0
Cherp	-303.0	3816.0
Chtop	-10030.0	10220.0
Cirh1a	10469.0	-8005.0
Clns1a	-1039.0	7103.0
Clp1	-6228.0	-9336.0
Cnot1	2862.0	4781.0
Cnot10	8561.0	1690.0
Cnot11	-131.0	2908.0
Cnot2	-6965.0	6675.0
Cnot3	-8690.0	6241.0
Cnot4	-7023.0	1964.0
Cnot6	-4378.0	2900.0
Cnot6l	6231.0	-12283.0
Cnot7	-8230.0	-5989.0
Cnot8	-10527.0	7261.0
Cpsf1	9323.0	-5728.0
Cpsf2	-6661.0	-4868.0
Cpsf3	8782.0	7679.0
Cpsf4	5771.0	-8596.0
Cpsf7	-4425.0	-9728.0
Crnkl1	-109.0	-7122.0
Csnk1d	4297.0	-10796.0
Csnk1e	10966.0	-7406.0
Cstf1	-244.0	4658.0
Cstf2	-8924.0	4400.0
Cstf2t	-10436.0	11223.0
Cstf3	-11359.0	4194.0
Ctnnbl1	12490.0	-6094.0
Ctu1	149.0	-4830.0
Ctu2	2492.0	5703.0
Cwc15	12190.0	-11387.0
Cwc22	10341.0	-11682.0
Cwc25	7441.0	-9920.0
Cwc27	14336.0	-12698.0
Dcaf13	7110.0	-10317.0
Dcp1a	-6339.0	-22.0
Dcp1b	-7546.0	6012.0
Dcp2	-11008.0	5190.0
Dcps	5953.0	-8102.0
Ddx1	-2614.0	-3147.0
Ddx20	-167.0	1093.0
Ddx21	-7792.0	2669.0
Ddx23	382.0	2772.0
Ddx39	-11177.0	11459.0
Ddx39b	3185.0	8599.0
Ddx42	-4136.0	-432.0
Ddx46	12600.0	-11452.0
Ddx47	13049.0	-11830.0
Ddx49	11080.0	-6073.0
Ddx5	-11965.0	1616.0
Ddx52	-8860.0	-9533.0
Ddx6	-1842.0	4460.0
Dhx15	-9796.0	3299.0
Dhx16	-8756.0	10003.0
Dhx37	-6165.0	10848.0
Dhx38	8619.0	7245.0
Dhx9	8525.0	9783.0
Diexf	-5014.0	6709.0
Dimt1	5090.0	-59.0
Dis3	-10317.0	11084.0
Dkc1	-9010.0	7070.0
Dnajc8	13615.0	-13888.0
Dus2	11688.0	12.0
Ebna1bp2	6632.0	4411.0
Edc3	14089.0	-14342.0
Edc4	8756.0	-6456.0
Eftud2	7632.0	9827.0
Eif4a1	3248.0	-13189.0
Eif4a2	-10764.0	-7297.0
Eif4a3	-2540.0	2589.0
Eif4b	-10769.0	8501.0
Eif4e	-6639.0	-8178.0
Eif4g1	-7805.0	7417.0
Elac2	5026.0	5862.0
Elavl1	-12111.0	12539.0
Elavl2	-5945.0	-1222.5
Emg1	-9703.0	4611.0
Enpp2	13793.0	-14844.0
Ercc2	-4287.0	6769.0
Ercc3	-8590.0	12277.0
Eri1	-9108.0	2577.0
Etf1	11859.0	-13240.0
Exosc1	-1652.0	-259.0
Exosc10	8632.0	5484.0
Exosc2	-4051.0	7454.0
Exosc3	-9773.0	11565.0
Exosc4	-6162.0	8972.0
Exosc5	-4859.0	4528.0
Exosc7	12464.0	-11384.0
Exosc8	-4592.0	-5642.0
Exosc9	14145.0	-12668.0
Fam98b	-9762.0	9328.0
Fbl	-4932.0	5426.0
Fcf1	13630.0	-14163.0
Flt3l	-10231.0	11283.0
Ftsj1	-9089.0	9372.0
Ftsj3	3001.0	-6694.0
Fus	9504.0	-10587.0
Fyttd1	-2420.0	-8408.0
Gar1	-5704.0	-2440.0
Gcfc2	-5561.0	6194.0
Gemin2	6181.0	-6885.0
Gemin4	-986.0	-7661.0
Gemin5	-7914.0	11222.0
Gemin6	-4033.0	-6732.0
Gemin7	-5750.0	10195.0
Gemin8	-3340.0	4843.0
Gle1	-10157.0	9176.0
Gm10263	6260.5	-6620.0
Gm7879	-5273.0	5954.5
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gnl3	10096.0	-12819.0
Gpkow	-3599.0	-292.0
Gprc5a	13014.0	-13387.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Gtf2f1	10842.0	-11838.0
Gtf2f2	11210.0	-13043.0
Gtf2h1	7733.0	-4523.0
Gtf2h2	-1662.0	9963.0
Gtf2h3	-5762.0	8221.0
Gtf2h4	-9248.0	10745.0
Gtf2h5	12700.0	-11987.0
Gtpbp3	5545.0	6695.0
Hbs1l	10371.0	3152.0
Heatr1	-11338.0	10893.0
Hnrnpa0	12561.0	-128.0
Hnrnpa1	15139.0	-15011.0
Hnrnpa2b1	-9300.0	-7338.0
Hnrnpa3	-8477.0	-12173.0
Hnrnpc	-11891.0	3326.0
Hnrnpd	7630.0	-11863.0
Hnrnpf	-10968.0	5012.0
Hnrnph1	-9519.0	-9068.0
Hnrnph2	-8410.0	7972.0
Hnrnpk	-72.0	319.0
Hnrnpl	7444.0	3133.0
Hnrnpm	-10425.0	9703.0
Hnrnpr	-11537.0	11176.0
Hnrnpu	-12178.0	11147.0
Hnrnpul1	10617.0	-7006.0
Hsd17b10	13714.0	-13444.0
Hspa1b	13713.0	-5345.0
Hspa8	-11121.0	9278.0
Hspb1	-10061.0	-8997.0
Igf2	13640.0	-11589.0
Igf2bp1	-12739.0	12987.0
Igf2bp2	13852.0	-14921.0
Igf2bp3	-3187.0	5360.0
Imp3	-5609.0	-8567.0
Imp4	8324.0	4833.0
Isg20l2	-7238.0	-230.0
Isy1	-2601.0	-8932.0
Khsrp	-7737.0	10297.0
Krr1	-3106.0	-6324.0
Lage3	11947.0	-12620.0
Las1l	12051.0	-9689.0
Lcmt2	-5073.0	8852.0
Lsm1	-1209.0	1922.0
Lsm10	-8202.0	5397.0
Lsm11	-10166.0	3429.0
Lsm2	-9648.0	6668.0
Lsm3	5066.0	-9516.0
Lsm4	-7750.0	4038.0
Lsm5	10023.0	-11694.0
Lsm6	13420.0	-10177.0
Lsm7	9918.0	-9406.0
Lsm8	12187.0	-11482.0
Ltv1	5893.0	2046.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Mapk11	-11176.0	11985.0
Mapk14	-12047.0	34.0
Mapkapk2	14192.0	-11215.0
Mettl1	-9724.0	10319.0
Mettl14	-9764.0	7709.0
Mettl3	-11428.0	8766.0
Mnat1	5792.0	4333.0
Mphosph10	-2542.0	-11771.0
Mphosph6	10241.0	-11218.0
Mrm1	8173.0	6939.0
mt-Atp6	6410.0	-2243.0
mt-Atp8	-606.5	-1222.5
mt-Co1	15116.0	-13378.0
mt-Co2	3815.0	1385.0
mt-Co3	-2109.5	2317.5
mt-Cytb	12116.0	-13032.0
mt-Nd1	13965.0	-13142.0
mt-Nd2	13232.0	-13777.0
mt-Nd3	5043.0	-3048.0
mt-Nd4	9342.0	-12167.0
mt-Nd5	13692.0	-13085.0
mt-Nd6	14568.0	-9103.0
Mterf4	4577.0	-5671.0
Mto1	-11583.0	8234.0
Nat10	-3010.0	4903.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Ncl	14307.0	-13602.0
Ndc1	13238.0	-12109.0
Nhp2	-4543.0	-7331.0
Nhp2l1	6307.0	-58.0
Nip7	13271.0	-13751.0
Nob1	-4352.0	-9473.0
Noc4l	10740.0	-5347.0
Nol11	-4875.0	8721.0
Nol12	-2586.0	7084.0
Nol6	8470.0	9046.0
Nol9	-11143.0	10670.0
Nop10	14932.0	-15027.0
Nop14	6664.0	-10954.0
Nop2	-11173.0	12322.0
Nop56	-4290.0	-9085.0
Nop58	-6387.0	-12931.0
Nsun2	14326.0	-11895.0
Nsun4	-2625.0	-8489.0
Nsun6	10846.0	-2912.0
Nt5c3b	12221.0	-10367.0
Nudt21	30.0	-10082.0
Nup107	-4524.0	-6225.0
Nup133	-6405.0	10731.0
Nup153	-10729.0	9979.0
Nup155	11046.0	-12223.0
Nup160	-7196.0	-7326.0
Nup188	-6119.0	7249.0
Nup205	5816.0	3749.0
Nup210	14542.0	-63.0
Nup214	13088.0	-10974.0
Nup35	-8231.0	10983.0
Nup37	-4813.0	9951.0
Nup43	8894.0	-8868.0
Nup54	-6950.0	2963.0
Nup62	-8836.0	8004.0
Nup85	-9207.0	9918.0
Nup88	14341.0	-12858.0
Nup93	12551.0	5537.0
Nup98	10837.0	4406.0
Nupl1	11303.0	-7772.0
Nxf1	-2596.0	-11904.0
Nxf2	2767.0	3620.0
Nxt1	14.0	4846.0
Osgep	12804.0	-11002.0
Pabpc2	1803.5	5051.0
Paip1	-11059.0	8960.0
Pan2	-3550.0	7089.0
Pan3	-6163.0	-10775.0
Papola	-10280.0	8135.0
Parn	12685.0	-10686.0
Patl1	-1794.0	-4692.0
Pcbp1	-11210.0	11754.0
Pcbp2	12658.0	-8098.0
Pcf11	6561.0	-12434.0
Pdcd11	-11181.0	12247.0
Pdcd7	7945.0	-6558.0
Pelp1	-87.0	8998.0
Pes1	12388.0	-11115.0
Phax	-68.0	-11128.0
Phf5a	-8954.0	8520.0
Plrg1	-55.0	2628.0
Pno1	9553.0	-8568.0
Pnrc2	-2276.0	-10147.0
Poldip3	-5888.0	11546.0
Polr2a	5917.0	6827.0
Polr2b	-9995.0	7496.0
Polr2c	-2600.0	9289.0
Polr2d	-4100.0	39.0
Polr2e	11726.0	-9159.0
Polr2f	11374.0	-6543.0
Polr2g	11118.0	-13257.0
Polr2h	224.0	-7426.0
Polr2i	13554.0	-12640.0
Polr2j	9902.0	-6099.0
Polr2k	7520.0	-11503.0
Polr2l	6213.0	4463.0
Pom121	9659.0	-12785.0
Pop1	-10690.0	-7264.0
Pop4	13788.0	-11243.0
Pop5	9312.0	-11899.0
Pop7	-5818.0	6970.0
Ppie	-3112.0	-7807.0
Ppil1	-8581.0	8573.0
Ppil3	-4118.0	-2331.0
Ppil4	7690.0	-11704.0
Ppil6	13976.0	-12930.0
Ppp2ca	2443.0	326.0
Ppp2r1a	11507.0	3755.0
Ppp2r2a	-1142.0	-9444.0
Ppwd1	-90.0	2912.0
Pqbp1	-2269.0	5269.0
Prcc	-8930.0	9487.0
Prkca	-11577.0	11021.0
Prkcd	11350.0	-8872.0
Prmt5	-7307.0	9222.0
Prpf19	6364.0	9592.0
Prpf3	-4162.0	5093.0
Prpf31	10994.0	-10786.0
Prpf38a	13192.0	-12521.0
Prpf4	3700.0	-7094.0
Prpf40a	5788.0	-9523.0
Prpf6	11227.0	-6867.0
Prpf8	-8672.0	12273.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Ptbp1	-6701.0	8839.0
Puf60	-8188.0	12693.0
Pus1	-3700.0	4431.0
Pus3	-7569.0	9576.0
Pus7	-1872.0	6474.0
Pwp2	-10371.0	9002.0
Qtrt1	-7782.0	6900.0
Qtrtd1	2949.0	1195.0
Rae1	-2818.0	7959.0
Ran	-340.0	-458.0
Ranbp2	-1884.0	-9227.0
Rbm17	12237.0	-13177.0
Rbm22	8713.0	-171.0
Rbm28	-8925.0	7344.0
Rbm5	-6938.0	-6541.0
Rbm8a2	-485.5	-1222.5
Rcl1	4228.0	-12272.0
Riok1	10886.0	-12644.0
Riok3	12673.0	-11776.0
Rngtt	-7630.0	-3160.0
Rnmt	8097.0	-11900.0
Rnmtl1	-9443.0	9410.0
Rnpc3	2829.0	-8715.0
Rnps1	11263.0	-12563.0
Rnu11	10010.0	-13706.0
Rnu12	11799.0	-13135.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rpp14	-4004.0	7707.0
Rpp21	13040.0	-10953.0
Rpp25	12542.0	-12010.0
Rpp30	-3330.0	-5143.0
Rpp38	12569.0	-5312.0
Rpp40	-11849.0	12707.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rrp1	12048.0	-7129.0
Rrp36	-3406.0	4080.0
Rrp7a	-8269.0	9929.0
Rrp9	-8119.0	5583.0
Rtcb	-8558.0	7002.0
Sarnp	-7702.0	-8205.0
Sart1	3328.0	3598.0
Sec13	9849.0	-12486.0
Seh1l	9415.0	-7505.0
Senp3	3387.0	-3767.0
Set	-7029.0	5919.0
Sf1	2891.0	-9855.0
Sf3a1	-9172.0	12488.0
Sf3a2	8425.0	-7087.0
Sf3a3	2509.0	5226.0
Sf3b1	48.0	-10659.0
Sf3b2	381.0	7311.0
Sf3b3	8532.0	6319.0
Sf3b4	-9210.0	11423.0
Sf3b5	9063.0	-11091.0
Sf3b6	-8730.0	-8433.0
Skiv2l	-7996.0	9509.0
Slbp	-3418.0	4264.0
Slu7	7246.0	-11136.0
Smg1	8862.0	-12241.0
Smg5	-7764.0	7622.0
Smg6	7235.0	-5765.0
Smg7	-83.0	2903.0
Smg8	4295.0	2512.0
Smg9	-8087.0	9030.0
Smn1	-9161.0	11326.0
Smndc1	208.0	-4355.0
Snrnp200	-10932.0	12656.0
Snrnp25	14068.0	-13554.0
Snrnp27	-3642.0	-9357.0
Snrnp35	10366.0	-8118.0
Snrnp40	4477.0	-5153.0
Snrnp48	-7389.0	-8908.0
Snrnp70	14435.0	-13362.0
Snrpa	-7891.0	6562.0
Snrpa1	10600.0	-4929.0
Snrpb	5854.0	6951.0
Snrpb2	-4199.0	-6223.0
Snrpc	4141.0	-5285.0
Snrpd1	-3478.0	-4268.0
Snrpd2	12210.0	-13322.0
Snrpd3	-6753.0	-7788.0
Snrpe	7178.0	-11998.0
Snrpf	-1614.0	-4619.0
Snrpn	-6431.0	7588.0
Snupn	-6005.0	9863.0
Snw1	11427.0	-10740.0
Srrm1	8286.0	-10454.0
Srrm2	12827.0	-13149.0
Srrt	-10569.0	12689.0
Srsf1	-12241.0	12023.0
Srsf10	-11358.0	6854.0
Srsf11	8799.0	-13439.0
Srsf2	-5811.0	7714.0
Srsf3	-9951.0	10690.0
Srsf4	13807.0	-14642.0
Srsf5	8302.0	-13500.0
Srsf6	-9341.0	-6969.0
Srsf7	-11936.0	10906.0
Srsf9	85.0	7145.0
Sugp1	12819.0	-6939.0
Supt5	12513.0	7510.0
Syf2	7963.0	-9682.0
Sympk	-3043.0	9735.0
Tbl3	11187.0	-4755.0
Tex10	13888.0	-13152.0
Tfb1m	-8554.0	11928.0
Tfip11	5659.0	8260.0
Tgs1	-7102.0	2547.0
Thada	-11092.0	12587.0
Thg1l	-9525.0	10333.0
Thoc1	8.0	-8260.0
Thoc2	-998.0	-7024.0
Thoc3	-4607.0	2871.0
Thoc5	6150.0	8187.0
Thoc6	-3759.0	1086.0
Thoc7	-9853.0	6025.0
Thumpd1	-5611.0	5187.0
Tnfsf13	11579.0	-13103.0
Tnks1bp1	4119.0	-14130.0
Tnpo1	9194.0	-10888.0
Tpr	-7568.0	-3358.0
Tprkb	-9049.0	11108.0
Tra2b	-6172.0	-8538.0
Trdmt1	10642.0	-107.0
Trit1	-8407.0	-7630.0
Trmt1	-6305.0	10577.0
Trmt10a	-3127.0	-12035.0
Trmt10c	-8268.0	-8771.0
Trmt11	-7457.0	1970.0
Trmt112	-11645.0	12227.0
Trmt12	-10461.0	9560.0
Trmt13	9365.0	-3555.0
Trmt44	10659.0	-12384.0
Trmt5	-4626.0	4327.0
Trmt6	5448.0	5983.0
Trmt61a	-8423.0	9060.0
Trmu	-1415.0	5944.0
Trnt1	12528.0	-12735.0
Trp53rka	-1156.0	-10812.0
Tsen15	6282.0	-2922.0
Tsen2	7863.0	-3229.0
Tsen34	-6058.0	11461.0
Tsen54	-4127.0	-402.0
Tsr1	-1495.0	-3588.0
Tsr3	3631.0	2131.0
Ttc37	-9819.0	6023.0
Txnl4a	-7680.0	-8218.0
Tyw1	10441.0	-10700.0
Tyw3	-6279.0	-4750.0
Tyw5	9429.0	-9005.0
U2af1	-8975.0	6594.0
U2af1l4	-10190.0	5080.0
U2af2	-11199.0	12578.0
U2surp	9178.0	-12801.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Upf1	-11946.0	12557.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0
Urm1	10615.0	3690.0
Usp39	-11050.0	288.0
Utp11l	-7005.0	-4860.0
Utp14a	-5133.0	-2742.0
Utp15	5938.0	1712.0
Utp18	-7826.0	-6737.0
Utp20	15103.0	-15017.0
Utp3	10392.0	-12353.0
Utp6	-11407.0	9055.0
Wbp11	9784.0	-2425.0
Wbp4	-10488.0	12044.0
Wbscr22	-8122.0	9241.0
Wdr12	-7739.0	-6258.0
Wdr18	-9867.0	7547.0
Wdr3	-9605.0	8188.0
Wdr33	205.0	-5468.0
Wdr36	-8873.0	-4579.0
Wdr4	-12377.0	11653.0
Wdr43	12457.0	-11762.0
Wdr46	-6655.0	10606.0
Wdr61	7816.0	-2432.0
Wdr75	-8085.0	372.0
Wdr77	-4297.0	9479.0
Wtap	-1502.0	-9889.0
Xab2	9670.0	-10721.0
Xpo1	-10778.0	9680.0
Xpot	-8359.0	1180.0
Xrn1	8185.0	-10108.0
Xrn2	12991.0	-13905.0
Ybx1	-11529.0	9803.0
Ywhab	-3531.0	-52.0
Zbtb8os	-5343.0	-8355.0
Zc3h11a	-1570.0	-415.0
Zcchc11	11123.0	-6985.0
Zcchc6	5516.0	-12027.0
Zcrb1	11610.0	-13501.0
Zfp36	13398.0	-13661.0
Zfp36l1	-10464.0	6254.0
Zfp473	11900.0	-4486.0
Zmat5	11972.0	2009.0
Zrsr1	-2407.0	-10719.0

---

---

Axon-guidance

Axon-guidance

metric	value
setSize	493
pMANOVA	4.1e-08
p.adjustMANOVA	1.45e-06
s.dist	0.188
s.diab	0.153
s.PMX	-0.109
p.diab	5.64e-09
p.PMX	2.99e-05

Top 20 genes

Gene	diab	PMX
Gpc1	15341	-15137
Ank2	15245	-15056
Sdcbp	15153	-15107
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Dnm3	15166	-14925
Plcg1	15140	-14853
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Gab2	15062	-14731
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Vav3	14614	-14980
Rpl23	14658	-14919

Click HERE to show all gene set members

All member genes

	diab	PMX
Abl1	6603.0	-4424.0
Abl2	-288.0	-9898.0
Ablim1	-7443.0	4633.0
Ablim2	12767.0	-6554.0
Ablim3	-7213.0	10291.0
Actb	-6959.0	10268.0
Actr2	-2414.0	-12954.0
Actr3	-1469.0	-2275.0
Adam10	-3927.0	-9154.0
Agap2	-10524.0	6616.0
Agrn	-2557.0	10075.0
Akap5	13260.0	-8998.0
Alcam	5532.0	3168.0
Ank1	11757.0	-7717.0
Ank2	15245.0	-15056.0
Ank3	13710.0	4675.0
Ap2a1	9324.0	5186.0
Ap2a2	-8561.0	11221.0
Ap2b1	-9075.0	10334.0
Ap2m1	11298.0	-6224.0
Ap2s1	11182.0	-5073.0
Aph1a	-620.0	4686.0
Aph1b	13941.0	-13577.0
Arhgap35	6886.0	10081.0
Arhgap39	-10187.0	12166.0
Arhgef11	9956.0	-369.0
Arhgef12	-12030.0	10200.0
Arhgef28	13237.0	-9111.0
Arhgef7	12872.0	-10663.0
Arpc1a	7337.0	4676.0
Arpc1b	13577.0	-14653.0
Arpc2	-3071.0	-7404.0
Arpc3	7146.0	-13389.0
Arpc4	9992.0	-4025.0
Artn	3241.0	-3141.0
Cacna1c	-9529.0	10981.0
Cacna1d	13918.0	-13958.0
Cacna1g	10347.0	10970.0
Cacna1h	-8487.0	10660.0
Cacna1i	-6194.0	8952.0
Cacna1s	12599.0	-6240.0
Cacnb1	-1436.0	314.0
Cacnb2	13987.0	-13437.0
Cacnb3	14958.0	-9946.0
Cacnb4	13292.0	-8106.0
Cap1	4211.0	6948.0
Cap2	3090.0	10302.0
Casc3	-213.0	8374.0
Cd24a	14160.0	-14864.0
Cd72	-9109.0	4997.0
Cdc42	-243.0	-9562.0
Cdk5	9839.0	2913.0
Cdk5r1	-4054.0	-4627.0
Cfl1	5160.0	-4928.0
Chl1	-11573.0	10771.0
Clasp1	8043.0	-6017.0
Clasp2	14039.0	-9470.0
Clta	-6346.0	5123.0
Cltb	9280.0	-9528.0
Cltc	8328.0	-9844.0
Cntn1	10493.0	1328.0
Cntn2	11393.0	-5235.0
Cntn6	7155.0	3635.0
Cntnap1	-5780.0	10384.0
Col4a1	5904.0	7644.0
Col4a2	12342.0	7010.0
Col4a3	-8719.0	8992.0
Col4a4	-10655.0	12060.0
Col4a5	12326.0	7452.0
Col6a1	-6512.0	11992.0
Col6a2	-4892.0	11714.0
Col6a3	-12679.0	12949.0
Col6a5	-7827.0	12669.0
Col6a6	-12588.0	12839.0
Col9a1	-1304.5	3868.0
Col9a2	4094.0	1499.0
Col9a3	-7324.0	5896.0
Creb1	-10512.0	8785.0
Crmp1	4879.0	1319.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Cul2	-7656.0	2073.0
Cxcl12	-241.0	6950.0
Cxcr4	7466.0	-10281.0
Dab1	14691.0	-14269.0
Dag1	14086.0	305.0
Dcx	-210.0	8162.0
Dlg1	12024.0	-11729.0
Dlg3	9912.0	3835.0
Dlg4	-7223.0	10585.0
Dnm1	15015.0	-13711.0
Dnm2	11590.0	-11213.0
Dnm3	15166.0	-14925.0
Dock1	-1492.0	11015.0
Dok1	-8745.0	-2753.0
Dok2	13393.0	-14065.0
Dok4	-10750.0	12430.0
Dok5	-10523.0	572.5
Dok6	4439.0	-5028.0
Dpysl2	-6335.0	10620.0
Dpysl3	15132.0	-14290.0
Dpysl4	8070.0	-4570.0
Dpysl5	13588.0	-13608.0
Dscam	8803.0	-278.0
Dscaml1	15314.0	9947.0
Efna1	-6227.0	3341.0
Efna2	4929.0	1978.0
Efna3	9591.0	6895.0
Efna4	6164.0	-152.0
Efna5	12556.0	-8473.0
Efnb1	-8854.0	9041.0
Efnb2	-12072.0	11855.0
Efnb3	-7464.0	4177.0
Egfr	-4839.0	7088.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Enah	14569.0	-14563.0
Epha1	-8874.0	6646.0
Epha2	9289.0	-10808.0
Epha3	4782.0	10040.0
Epha4	-11463.0	8951.0
Epha6	6468.0	3710.0
Epha7	-6152.0	-13648.0
Epha8	11137.0	-8195.0
Ephb2	10855.0	-12717.0
Ephb3	-12468.0	12274.0
Ephb6	6173.0	-31.0
Erbb2	-310.0	-10575.0
Etf1	11859.0	-13240.0
Evl	-8437.0	11927.0
Ezr	11158.0	1703.0
Farp2	10013.0	-12337.0
Fes	-3932.0	7764.0
Fgfr1	-7796.0	5994.0
Flrt3	-7375.0	-4075.0
Flt3l	-10231.0	11283.0
Frs2	7964.0	-10324.0
Fyn	-6985.0	9856.0
Gab1	-9889.0	-8445.0
Gab2	15062.0	-14731.0
Gap43	1803.5	875.5
Gdnf	4273.0	2051.0
Gfra1	-10676.0	-12943.0
Gfra2	-6389.0	7963.0
Gfra3	3371.0	-6871.0
Gfra4	11056.0	197.0
Git1	13031.0	-6200.0
Gm10263	6260.5	-6620.0
Gm16372	3066.0	-6464.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gpc1	15341.0	-15137.0
Grb10	-10947.0	9629.0
Grb2	8972.0	3406.0
Grb7	-12186.0	12119.0
Grin1	8164.0	3365.0
Grin2b	7538.0	-7715.0
Gsk3b	-6315.0	7700.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Hfe2	2658.5	-2791.5
Hoxa2	6369.0	2887.0
Hras	12615.0	-11955.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Hspa8	-11121.0	9278.0
Irs2	6763.0	-10676.0
Itga1	9086.0	6502.0
Itga10	-7763.0	-6633.0
Itga2	7236.0	-6041.0
Itga2b	4836.0	-5064.0
Itga5	-6316.0	4295.0
Itga9	-12089.0	12867.0
Itgav	14776.0	-14797.0
Itgb1	5869.0	-13098.0
Itgb3	12310.0	-13769.0
Itsn1	-6360.0	7586.0
Kalrn	13678.0	-5190.0
Kcnq2	2579.0	-4106.0
Kcnq3	-9922.0	-7422.0
Kif4	12410.0	-10273.0
Kras	8243.0	-12396.0
L1cam	15340.0	-13068.0
Lama1	-6518.0	12437.0
Lamb1	-8857.0	11401.0
Lamc1	13297.0	-9372.0
Ldb1	13326.0	-12215.0
Lhx2	9446.0	-6616.0
Lhx3	-665.5	3249.0
Lhx9	4055.0	-4216.0
Limk1	11390.0	3370.0
Limk2	14475.0	-9474.0
Lyn	-7639.0	6.0
Lypla2	-6762.0	11924.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Map2k1	14770.0	-11245.0
Map2k2	-6785.0	5610.0
Mapk1	6867.0	-10406.0
Mapk11	-11176.0	11985.0
Mapk12	-9900.0	10805.0
Mapk13	15241.0	-11923.0
Mapk14	-12047.0	34.0
Mapk3	10588.0	-6813.0
Mapk7	-1452.0	6080.0
Mapk8	86.0	2880.0
Met	-12780.0	12742.0
Mmp2	14979.0	-11708.0
Mmp9	-9378.0	9026.0
Msi1	13972.0	-10430.0
Msn	9027.0	4065.0
Myh10	9979.0	12027.0
Myh11	10080.0	12361.0
Myh14	10015.0	-8495.0
Myh9	-3199.0	2907.0
Myl12a	12279.0	-13551.0
Myl12b	10115.0	-13120.0
Myl6	11221.0	-14108.0
Myl9	9432.0	-4957.0
Myo10	-6537.0	-7117.0
Myo9b	4209.0	8589.0
Ncam1	13434.0	-8163.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Nck1	-4016.0	-10473.0
Nck2	-5920.0	1627.0
Ncstn	14410.0	-12169.0
Nell2	9389.0	7424.0
Neo1	13672.0	-8520.0
Nfasc	10990.0	-11851.0
Ngef	-11571.0	-8755.0
Nras	11707.0	-12390.0
Nrcam	13750.0	-13217.0
Nrp1	-10538.0	3551.0
Nrp2	-11608.0	12652.0
Nrtn	12494.0	-11907.0
Ntn1	-12657.0	12445.0
Ntn4	-11679.0	12792.0
Numb	-4855.0	5859.0
Pabpc2	1803.5	5051.0
Pak1	9007.0	-10571.0
Pak2	-11115.0	10419.0
Pak3	9025.0	-9081.0
Pak4	2963.0	-7078.0
Pak6	13683.0	-13884.0
Pak7	-6905.0	2039.0
Pdlim7	26.0	-7844.0
Pfn1	-2444.0	4731.0
Pfn2	14209.0	-14087.0
Pik3ca	5274.0	-12270.0
Pik3cb	-11168.0	9586.0
Pik3cd	-8249.0	9542.0
Pik3r1	-5226.0	4551.0
Pik3r2	-4478.0	11254.0
Pik3r3	13321.0	6430.0
Pip5k1c	12377.0	9141.0
Pitpna	8448.0	-7392.0
Plcg1	15140.0	-14853.0
Plxna1	9987.0	12159.0
Plxna2	7960.0	11857.0
Plxna3	8860.0	-4497.0
Plxna4	12340.0	7720.0
Plxnb1	11092.0	-4388.0
Plxnb3	9800.0	3436.0
Plxnc1	-9178.0	11460.0
Plxnd1	-12438.0	12973.0
Ppp3cb	-6472.0	4604.0
Prkaca	-8030.0	10329.0
Prkacb	-256.0	3728.0
Prkar2a	13537.0	-12751.0
Prkca	-11577.0	11021.0
Prkcq	-6737.0	3402.0
Prnp	-9879.0	-10677.0
Psen1	-11531.0	9651.0
Psen2	7176.0	-5828.0
Psenen	-7498.0	6057.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Pspn	3658.0	-3853.0
Ptk2	9305.0	2859.0
Ptpn11	-3808.0	6242.0
Ptpra	-12291.0	12403.0
Ptprc	-12569.0	12780.0
Rac1	-4047.0	262.0
Ranbp9	5827.0	-10322.0
Rap1gap	12758.0	-9245.0
Rasa1	-6341.0	6192.0
Rbm8a2	-485.5	-1222.5
Rbx1	2286.0	4532.0
Rdx	-9038.0	7135.0
Reln	5678.0	-13794.0
Ret	169.0	-7826.0
Rgma	-3969.0	6866.0
Rgmb	13555.0	-12031.0
Rhob	9640.0	-12113.0
Rhoc	-10110.0	8403.0
Rnd1	-10960.0	10295.0
Rnps1	11263.0	-12563.0
Robo1	4284.0	7975.0
Robo2	-10164.0	12956.0
Robo3	-12220.0	10440.0
Rock1	4877.0	-11833.0
Rock2	7938.0	-13372.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Rps6ka4	-3914.0	11808.0
Rps6ka5	45.0	2524.0
Rps6ka6	-2720.0	-6681.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rras	9635.0	-13646.0
Scn11a	4094.0	4137.5
Scn1a	7990.0	-4949.0
Scn1b	12992.0	-10197.0
Scn2b	3274.0	4282.0
Scn3a	8357.0	-10682.0
Scn3b	7714.0	2635.0
Scn4a	11181.0	1624.0
Scn4b	8069.0	10612.0
Scn5a	13114.0	-14558.0
Scn7a	-8259.0	11696.0
Scn8a	14362.0	-13369.0
Sdc2	-11747.0	10378.0
Sdcbp	15153.0	-15107.0
Sema3a	11254.0	-12343.0
Sema3e	-1439.0	7677.0
Sema4a	8835.0	10255.0
Sema4d	-12323.0	13004.0
Sema5a	-3839.0	-4874.0
Sema6a	-8616.0	1774.0
Sema6d	-11742.0	9957.0
Sema7a	-369.0	4584.0
Sh3gl2	-11302.0	-5104.0
Sh3kbp1	6066.0	-2951.0
Shank3	-8064.0	11859.0
Shc1	-8826.0	9471.0
Shc3	-11316.0	8814.0
Shtn1	-11564.0	12357.0
Siah1b	-5724.0	7247.0
Siah2	-10891.0	11293.0
Slit1	10290.0	-10823.0
Slit2	-9878.0	9321.0
Slit3	12952.0	-6476.0
Sos1	-11977.0	9665.0
Sos2	-5483.0	3046.0
Spta1	-10792.0	12612.0
Sptan1	14829.0	-14042.0
Sptb	11519.0	-178.0
Sptbn1	14290.0	-14606.0
Sptbn2	15226.0	-13965.0
Sptbn4	-5.0	-8696.0
Sptbn5	12488.0	-12972.0
Src	8646.0	4243.0
Srgap1	9493.0	11288.0
Srgap2	10271.0	-10418.0
Srgap3	14988.0	-14259.0
St8sia2	12735.0	-13219.0
St8sia4	-11567.0	12370.0
Tiam1	13330.0	-11554.0
Tln1	-11767.0	12745.0
Trem2	14131.0	-9686.0
Trio	-9497.0	12173.0
Trpc1	-6951.0	-4789.0
Trpc3	10273.0	-9076.0
Trpc4	-6392.0	8840.0
Trpc5	-5585.0	10887.0
Trpc6	6831.0	-2979.0
Tyrobp	-4198.0	-8348.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Unc5a	-8229.0	9426.0
Unc5b	14534.0	9226.0
Unc5c	-12014.0	12328.0
Unc5d	-5359.5	-3929.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0
Usp33	-8958.0	-3443.0
Vasp	-3832.0	4449.0
Vav2	-4852.0	12450.0
Vav3	14614.0	-14980.0
Vldlr	-11073.0	2870.0
Wasl	6310.0	-10820.0
Yes1	4717.0	-6854.0
Zswim8	12845.0	-11226.0

---

---

Ion-channel-transport

Ion-channel-transport

metric	value
setSize	167
pMANOVA	1.65e-07
p.adjustMANOVA	5.67e-06
s.dist	0.202
s.diab	0.2
s.PMX	-0.0276
p.diab	7.78e-06
p.PMX	0.538

Top 20 genes

Gene	diab	PMX
Clcnka	15331	-15102
Atp1a1	15329	-15091
Atp1b1	15270	-15047
Atp13a4	15075	-14827
Atp6v0e	14931	-14952
Atp6v0a4	15332	-14499
Atp2c2	14695	-14840
Sgk1	14467	-15065
Ano3	15020	-14380
Ano9	14626	-14425
Fxyd4	14187	-14477
Atp7a	14760	-13906
Mcoln3	14908	-13736
Rps27a	13894	-14715
Camk2d	14624	-13868
Atp6v1g1	15089	-12782
Atp12a	14693	-13086
Atp11b	13104	-14661
Atp6v1f	14121	-13473
Camk2b	12864	-14402

Click HERE to show all gene set members

All member genes

	diab	PMX
Ano1	-6646.0	11672.0
Ano10	14497.0	-10908.0
Ano2	-5297.0	5752.0
Ano3	15020.0	-14380.0
Ano4	13655.0	-13262.0
Ano5	-5027.0	10651.0
Ano6	-8051.0	10904.0
Ano7	-2943.0	-2073.5
Ano8	7029.0	11575.0
Ano9	14626.0	-14425.0
Asic1	4570.0	4100.0
Asic2	11272.0	-6067.0
Asic3	13063.0	-12983.0
Asic4	2517.0	9770.0
Asic5	12038.0	-13122.0
Asph	14868.0	-10498.0
Atp10a	6732.0	6850.0
Atp10b	14389.0	1602.0
Atp10d	-11585.0	10455.0
Atp11a	-12354.0	11119.0
Atp11b	13104.0	-14661.0
Atp11c	-7165.0	-4858.0
Atp12a	14693.0	-13086.0
Atp13a1	-5438.0	8064.0
Atp13a2	5750.0	11413.0
Atp13a4	15075.0	-14827.0
Atp13a5	4094.0	-4251.0
Atp1a1	15329.0	-15091.0
Atp1a2	-11450.0	12843.0
Atp1a3	156.0	6565.0
Atp1a4	-3227.0	3852.5
Atp1b1	15270.0	-15047.0
Atp1b2	-10533.0	11952.0
Atp1b3	9790.0	-13383.0
Atp2a1	7434.0	-9596.0
Atp2a2	-8496.0	5103.0
Atp2a3	13296.0	-8272.0
Atp2b1	-1035.0	-10412.0
Atp2b2	-9825.0	12073.0
Atp2b3	-2739.0	-1222.5
Atp2b4	14526.0	11906.0
Atp2c1	-10376.0	6936.0
Atp2c2	14695.0	-14840.0
Atp4a	10523.0	11730.0
Atp6ap1	7214.0	2925.0
Atp6v0a1	8644.0	-4832.0
Atp6v0a2	-3899.0	-7579.0
Atp6v0a4	15332.0	-14499.0
Atp6v0b	4840.0	2125.0
Atp6v0c	3151.0	-10611.0
Atp6v0d1	203.0	1912.0
Atp6v0d2	15150.0	-3904.0
Atp6v0e	14931.0	-14952.0
Atp6v0e2	7872.0	6422.0
Atp6v1a	10227.0	-7433.0
Atp6v1b1	13172.0	12006.0
Atp6v1b2	-7304.0	5553.0
Atp6v1c1	12161.0	-10561.0
Atp6v1c2	14305.0	9508.0
Atp6v1d	12172.0	-14697.0
Atp6v1e1	13351.0	-11187.0
Atp6v1f	14121.0	-13473.0
Atp6v1g1	15089.0	-12782.0
Atp6v1g2	-3055.0	4701.0
Atp6v1g3	14162.0	-9021.0
Atp6v1h	9566.0	-8530.0
Atp7a	14760.0	-13906.0
Atp7b	-10796.0	2779.0
Atp8a1	6168.0	-5849.0
Atp8a2	4721.0	1353.0
Atp8b1	11100.0	-5622.0
Atp8b2	-9832.0	8629.0
Atp8b3	8520.5	-7611.0
Atp8b4	-12567.0	8273.0
Atp9a	-6057.0	8712.0
Atp9b	7035.0	14.0
Best1	-10167.0	9636.0
Best2	-3527.0	5890.0
Best3	13186.0	-8610.0
Bsnd	-7804.0	12651.0
Calm1	152.0	-11443.0
Camk2a	-8582.0	9297.0
Camk2b	12864.0	-14402.0
Camk2d	14624.0	-13868.0
Camk2g	-9180.0	8979.0
Clca1	4094.0	-4251.0
Clca2	-4679.5	8091.0
Clca4b	-2109.5	2317.5
Clcn1	11915.0	-9619.0
Clcn2	6024.0	-3161.0
Clcn3	-12390.0	8666.0
Clcn4	-12440.0	8743.0
Clcn5	10105.0	-6296.0
Clcn6	4525.0	10762.0
Clcn7	9462.0	-4788.0
Clcnka	15331.0	-15102.0
Cutc	-8224.0	6963.0
Fkbp1b	-10268.0	8412.0
Fxyd1	-7377.0	9606.0
Fxyd2	-5577.0	-12198.0
Fxyd3	6682.5	2778.0
Fxyd4	14187.0	-14477.0
Fxyd6	11278.0	-8487.0
Fxyd7	-3913.0	4945.0
Mcoln1	5013.0	7399.0
Mcoln2	12057.0	-13831.0
Mcoln3	14908.0	-13736.0
Nalcn	12364.0	-8781.0
Nedd4l	11295.0	-14092.0
Ostm1	12347.0	-11828.0
Pdzd11	-6450.0	2974.0
Pln	-4956.0	12078.0
Raf1	-10208.0	10796.0
Rps27a	13894.0	-14715.0
Ryr1	-5087.0	8615.0
Ryr2	-12616.0	9950.0
Ryr3	5642.0	-3172.0
Scnn1a	14690.0	-8748.0
Scnn1b	14548.0	8042.0
Scnn1g	14166.0	8691.0
Sgk1	14467.0	-15065.0
Sgk2	-4525.0	12091.0
Sgk3	-7293.0	-2896.0
Slc17a3	-12136.0	9781.0
Slc9b1	11349.0	-10055.0
Slc9b2	10920.0	-7956.0
Sri	12407.0	-12509.0
Stom	12517.0	-9869.0
Stoml3	-291.0	-5967.0
Tcirg1	-10070.0	11128.0
Tpcn1	-10142.0	11915.0
Tpcn2	13203.0	-6818.0
Trdn	-10470.0	10096.0
Trpa1	876.5	-1222.5
Trpc1	-6951.0	-4789.0
Trpc3	10273.0	-9076.0
Trpc4	-6392.0	8840.0
Trpc4ap	7349.0	2894.0
Trpc5	-5585.0	10887.0
Trpc6	6831.0	-2979.0
Trpm1	11426.0	-11742.0
Trpm2	-10909.0	10172.0
Trpm3	14838.0	-11739.0
Trpm4	13796.0	-10685.0
Trpm5	11164.0	-10651.0
Trpm6	14929.0	44.0
Trpm7	11984.0	-10066.0
Trpm8	11921.0	-9153.0
Trpv1	-7444.0	5701.0
Trpv2	-8461.0	11896.0
Trpv3	10609.0	-12369.0
Trpv4	-10161.0	9435.0
Trpv5	14650.0	5808.0
Trpv6	13566.0	-9491.0
Tsc22d3	11831.0	-15069.0
Ttyh1	-10815.0	10702.0
Ttyh2	-5397.0	10338.0
Ttyh3	13483.0	-11529.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Unc79	10784.0	-6903.0
Unc80	11709.0	7333.0
Wnk1	13335.0	11026.0
Wnk2	8206.0	-103.0
Wnk3	12524.0	-13817.0
Wnk4	13762.0	-4931.0
Wwp1	-12213.0	11633.0

---

---

Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell

Immunoregulatory-interactions-between-a-Lymphoid-and-a-non-Lymphoid-cell

metric	value
setSize	94
pMANOVA	1.69e-07
p.adjustMANOVA	5.69e-06
s.dist	0.419
s.diab	-0.258
s.PMX	0.33
p.diab	1.5e-05
p.PMX	3.11e-08

Top 20 genes

Gene	diab	PMX
Itgb7	-12362	12913
Itgal	-11771	12813
Fcgr2b	-12618	11370
Slamf7	-11802	11993
Lilra5	-11434	12254
Siglech	-11133	12378
Igkc	-12203	11173
Itga4	-10182	12732
Icam2	-10654	12128
Cd22	-11312	11195
Klrk1	-10390	11567
Pilra	-10977	10803
Cd40	-10536	10861
Igkv1-135	-9391	12146
Sell	-11269	9620
Cd8a	-8096	11902
Cd3d	-9851	9288
Clec2h	-7366	12365
Vcam1	-10545	8429
Siglecg	-7087	11103

Click HERE to show all gene set members

All member genes

	diab	PMX
Amica1	3041.0	6302.0
B2m	15002.0	-15005.0
C3	15250.0	-14907.0
Cd160	-7041.0	-2213.0
Cd19	-7122.0	7102.0
Cd1d2	-3716.0	-3233.0
Cd200	-2644.0	11237.0
Cd200r1	-7184.0	10869.0
Cd22	-11312.0	11195.0
Cd226	-8654.0	7366.0
Cd247	-6082.0	11572.0
Cd300a	-6899.0	-29.0
Cd300e	9565.0	5412.0
Cd300lb	3221.0	7216.0
Cd300ld	-10457.0	-4290.0
Cd300lg	3080.0	7292.0
Cd34	4523.0	8812.0
Cd3d	-9851.0	9288.0
Cd3e	-8888.0	6762.0
Cd3g	-9324.0	8029.0
Cd40	-10536.0	10861.0
Cd40lg	-5092.0	7913.0
Cd81	14129.0	6539.0
Cd8a	-8096.0	11902.0
Cd8b1	-4721.0	10118.0
Cd96	6970.0	147.0
Cdh1	-174.0	12292.0
Clec2h	-7366.0	12365.0
Clec4g	2372.0	3582.0
Colec12	4741.0	1796.0
Crtam	13922.0	-11801.0
Fcgr1	-8315.0	8531.0
Fcgr2b	-12618.0	11370.0
Fcgr4	-10480.0	3470.0
Gm1123	9928.0	-12705.0
Hcst	2793.0	5428.0
Icam1	12408.0	-14411.0
Icam2	-10654.0	12128.0
Icam4	-187.0	1799.0
Icam5	-4768.0	7615.0
Ifitm7	-9187.0	7115.0
Ighv14-1	-4909.0	-6534.0
Ighv3-1	-3456.5	2317.5
Ighv5-4	-8748.0	6914.0
Ighv9-1	-5234.0	4881.0
Igkc	-12203.0	11173.0
Igkv1-135	-9391.0	12146.0
Igkv14-130	-3167.5	2317.5
Igkv17-127	-10984.0	6315.0
Igkv2-137	6752.0	-10319.0
Igll1	11837.0	-7314.0
Iglv3	-6624.0	4066.0
Itga4	-10182.0	12732.0
Itgal	-11771.0	12813.0
Itgb1	5869.0	-13098.0
Itgb2l	4949.0	-3001.0
Itgb7	-12362.0	12913.0
Klrb1a	2613.5	-3967.0
Klrc3	-2109.5	3772.5
Klrd1	-8019.0	8245.0
Klrg1	-4806.5	1217.0
Klrk1	-10390.0	11567.0
Lair1	-8245.0	3311.0
Lilra5	-11434.0	12254.0
Lilrb4a	-3612.0	1943.0
Madcam1	4094.0	-2795.0
Mill1	-3167.5	2317.5
Ncr1	-6816.0	8309.0
Nectin2	14700.0	-12326.0
Npdc1	12285.0	-12484.0
Oscar	-2467.0	3540.0
Pianp	-4931.0	8498.0
Pilra	-10977.0	10803.0
Pvr	12149.0	-11086.0
Sell	-11269.0	9620.0
Sh2d1a	-3185.0	7063.0
Sh2d1b2	1803.5	-2073.5
Siglec1	12928.0	-12870.0
Siglece	-9930.0	6429.0
Siglecg	-7087.0	11103.0
Siglech	-11133.0	12378.0
Slamf6	-1182.0	4849.0
Slamf7	-11802.0	11993.0
Trac	-164.0	8877.0
Trbc1	-351.0	11521.0
Trbv15	876.5	5383.0
Trem1	6582.0	255.0
Trem2	14131.0	-9686.0
Treml1	-4582.0	-4976.0
Treml2	3884.0	4197.0
Treml4	-5513.0	7916.0
Tyrobp	-4198.0	-8348.0
Ulbp1	-6037.0	7275.0
Vcam1	-10545.0	8429.0

---

---

Nervous-system-development

Nervous-system-development

metric	value
setSize	517
pMANOVA	2.12e-07
p.adjustMANOVA	6.99e-06
s.dist	0.176
s.diab	0.142
s.PMX	-0.104
p.diab	3.2e-08
p.PMX	4.78e-05

Top 20 genes

Gene	diab	PMX
Gpc1	15341	-15137
Ank2	15245	-15056
Sdcbp	15153	-15107
Rplp1	15259	-14929
Rpl32	15195	-14957
Rps11	15181	-14944
Dnm3	15166	-14925
Plcg1	15140	-14853
Rps17	14996	-14975
Rpl12	15157	-14798
Rps24	15030	-14883
Rps16	15113	-14800
Gab2	15062	-14731
Rps26	15026	-14729
Rpl37a	15203	-14541
Rpl39	14758	-14951
Rps29	14692	-15018
Rpl38	14848	-14852
Vav3	14614	-14980
Rpl23	14658	-14919

Click HERE to show all gene set members

All member genes

	diab	PMX
Abl1	6603.0	-4424.0
Abl2	-288.0	-9898.0
Ablim1	-7443.0	4633.0
Ablim2	12767.0	-6554.0
Ablim3	-7213.0	10291.0
Actb	-6959.0	10268.0
Actr2	-2414.0	-12954.0
Actr3	-1469.0	-2275.0
Adam10	-3927.0	-9154.0
Adgrg6	12923.0	-14467.0
Adgrv1	10549.0	-5789.0
Agap2	-10524.0	6616.0
Agrn	-2557.0	10075.0
Akap5	13260.0	-8998.0
Alcam	5532.0	3168.0
Ank1	11757.0	-7717.0
Ank2	15245.0	-15056.0
Ank3	13710.0	4675.0
Ap2a1	9324.0	5186.0
Ap2a2	-8561.0	11221.0
Ap2b1	-9075.0	10334.0
Ap2m1	11298.0	-6224.0
Ap2s1	11182.0	-5073.0
Aph1a	-620.0	4686.0
Aph1b	13941.0	-13577.0
Arhgap35	6886.0	10081.0
Arhgap39	-10187.0	12166.0
Arhgef11	9956.0	-369.0
Arhgef12	-12030.0	10200.0
Arhgef28	13237.0	-9111.0
Arhgef7	12872.0	-10663.0
Arpc1a	7337.0	4676.0
Arpc1b	13577.0	-14653.0
Arpc2	-3071.0	-7404.0
Arpc3	7146.0	-13389.0
Arpc4	9992.0	-4025.0
Artn	3241.0	-3141.0
Cacna1c	-9529.0	10981.0
Cacna1d	13918.0	-13958.0
Cacna1g	10347.0	10970.0
Cacna1h	-8487.0	10660.0
Cacna1i	-6194.0	8952.0
Cacna1s	12599.0	-6240.0
Cacnb1	-1436.0	314.0
Cacnb2	13987.0	-13437.0
Cacnb3	14958.0	-9946.0
Cacnb4	13292.0	-8106.0
Cap1	4211.0	6948.0
Cap2	3090.0	10302.0
Casc3	-213.0	8374.0
Cd24a	14160.0	-14864.0
Cd72	-9109.0	4997.0
Cdc42	-243.0	-9562.0
Cdk5	9839.0	2913.0
Cdk5r1	-4054.0	-4627.0
Cfl1	5160.0	-4928.0
Chl1	-11573.0	10771.0
Clasp1	8043.0	-6017.0
Clasp2	14039.0	-9470.0
Clta	-6346.0	5123.0
Cltb	9280.0	-9528.0
Cltc	8328.0	-9844.0
Cntn1	10493.0	1328.0
Cntn2	11393.0	-5235.0
Cntn6	7155.0	3635.0
Cntnap1	-5780.0	10384.0
Col4a1	5904.0	7644.0
Col4a2	12342.0	7010.0
Col4a3	-8719.0	8992.0
Col4a4	-10655.0	12060.0
Col4a5	12326.0	7452.0
Col6a1	-6512.0	11992.0
Col6a2	-4892.0	11714.0
Col6a3	-12679.0	12949.0
Col6a5	-7827.0	12669.0
Col6a6	-12588.0	12839.0
Col9a1	-1304.5	3868.0
Col9a2	4094.0	1499.0
Col9a3	-7324.0	5896.0
Creb1	-10512.0	8785.0
Crmp1	4879.0	1319.0
Csnk2a1	111.0	-6883.0
Csnk2a2	4776.0	-8371.0
Csnk2b	4564.0	-136.0
Cul2	-7656.0	2073.0
Cxcl12	-241.0	6950.0
Cxcr4	7466.0	-10281.0
Cyp51	11509.0	-15089.0
Dab1	14691.0	-14269.0
Dag1	14086.0	305.0
Dcx	-210.0	8162.0
Dlg1	12024.0	-11729.0
Dlg3	9912.0	3835.0
Dlg4	-7223.0	10585.0
Dnm1	15015.0	-13711.0
Dnm2	11590.0	-11213.0
Dnm3	15166.0	-14925.0
Dock1	-1492.0	11015.0
Dok1	-8745.0	-2753.0
Dok2	13393.0	-14065.0
Dok4	-10750.0	12430.0
Dok5	-10523.0	572.5
Dok6	4439.0	-5028.0
Dpysl2	-6335.0	10620.0
Dpysl3	15132.0	-14290.0
Dpysl4	8070.0	-4570.0
Dpysl5	13588.0	-13608.0
Drp2	2856.0	-2916.0
Dscam	8803.0	-278.0
Dscaml1	15314.0	9947.0
Efna1	-6227.0	3341.0
Efna2	4929.0	1978.0
Efna3	9591.0	6895.0
Efna4	6164.0	-152.0
Efna5	12556.0	-8473.0
Efnb1	-8854.0	9041.0
Efnb2	-12072.0	11855.0
Efnb3	-7464.0	4177.0
Egfr	-4839.0	7088.0
Egr2	-8943.0	6151.0
Eif4a3	-2540.0	2589.0
Eif4g1	-7805.0	7417.0
Enah	14569.0	-14563.0
Epha1	-8874.0	6646.0
Epha2	9289.0	-10808.0
Epha3	4782.0	10040.0
Epha4	-11463.0	8951.0
Epha6	6468.0	3710.0
Epha7	-6152.0	-13648.0
Epha8	11137.0	-8195.0
Ephb2	10855.0	-12717.0
Ephb3	-12468.0	12274.0
Ephb6	6173.0	-31.0
Erbb2	-310.0	-10575.0
Etf1	11859.0	-13240.0
Evl	-8437.0	11927.0
Ezr	11158.0	1703.0
Farp2	10013.0	-12337.0
Fes	-3932.0	7764.0
Fgfr1	-7796.0	5994.0
Flrt3	-7375.0	-4075.0
Flt3l	-10231.0	11283.0
Frs2	7964.0	-10324.0
Fyn	-6985.0	9856.0
Gab1	-9889.0	-8445.0
Gab2	15062.0	-14731.0
Gap43	1803.5	875.5
Gdnf	4273.0	2051.0
Gfra1	-10676.0	-12943.0
Gfra2	-6389.0	7963.0
Gfra3	3371.0	-6871.0
Gfra4	11056.0	197.0
Git1	13031.0	-6200.0
Gjb1	-1862.0	-13995.0
Gm10263	6260.5	-6620.0
Gm16372	3066.0	-6464.0
Gm8973	-3589.0	2317.5
Gm9843	8515.0	-10259.0
Gpc1	15341.0	-15137.0
Grb10	-10947.0	9629.0
Grb2	8972.0	3406.0
Grb7	-12186.0	12119.0
Grin1	8164.0	3365.0
Grin2b	7538.0	-7715.0
Gsk3b	-6315.0	7700.0
Gspt1	-11131.0	7388.0
Gspt2	12160.0	-12675.0
Hdac2	-9129.0	7139.0
Hfe2	2658.5	-2791.5
Hmgcr	-11695.0	-12651.0
Hoxa2	6369.0	2887.0
Hras	12615.0	-11955.0
Hsp90aa1	-12505.0	4614.0
Hsp90ab1	-12580.0	11764.0
Hspa8	-11121.0	9278.0
Irs2	6763.0	-10676.0
Itga1	9086.0	6502.0
Itga10	-7763.0	-6633.0
Itga2	7236.0	-6041.0
Itga2b	4836.0	-5064.0
Itga5	-6316.0	4295.0
Itga9	-12089.0	12867.0
Itgav	14776.0	-14797.0
Itgb1	5869.0	-13098.0
Itgb3	12310.0	-13769.0
Itsn1	-6360.0	7586.0
Kalrn	13678.0	-5190.0
Kcnq2	2579.0	-4106.0
Kcnq3	-9922.0	-7422.0
Kif4	12410.0	-10273.0
Kras	8243.0	-12396.0
L1cam	15340.0	-13068.0
Lama1	-6518.0	12437.0
Lama2	-12274.0	12567.0
Lamb1	-8857.0	11401.0
Lamc1	13297.0	-9372.0
Ldb1	13326.0	-12215.0
Lhx2	9446.0	-6616.0
Lhx3	-665.5	3249.0
Lhx9	4055.0	-4216.0
Limk1	11390.0	3370.0
Limk2	14475.0	-9474.0
Lyn	-7639.0	6.0
Lypla2	-6762.0	11924.0
Mag	6844.0	-8991.0
Magoh	10249.0	-10772.0
Magohb	8299.0	-10115.0
Map2k1	14770.0	-11245.0
Map2k2	-6785.0	5610.0
Mapk1	6867.0	-10406.0
Mapk11	-11176.0	11985.0
Mapk12	-9900.0	10805.0
Mapk13	15241.0	-11923.0
Mapk14	-12047.0	34.0
Mapk3	10588.0	-6813.0
Mapk7	-1452.0	6080.0
Mapk8	86.0	2880.0
Mbp	14194.0	3469.0
Met	-12780.0	12742.0
Mmp2	14979.0	-11708.0
Mmp9	-9378.0	9026.0
Mpz	11473.0	-447.0
Msi1	13972.0	-10430.0
Msn	9027.0	4065.0
Myh10	9979.0	12027.0
Myh11	10080.0	12361.0
Myh14	10015.0	-8495.0
Myh9	-3199.0	2907.0
Myl12a	12279.0	-13551.0
Myl12b	10115.0	-13120.0
Myl6	11221.0	-14108.0
Myl9	9432.0	-4957.0
Myo10	-6537.0	-7117.0
Myo9b	4209.0	8589.0
Nab1	-9570.0	4452.0
Nab2	-12557.0	12629.0
Ncam1	13434.0	-8163.0
Ncbp1	-10261.0	11996.0
Ncbp2	-12122.0	10343.0
Nck1	-4016.0	-10473.0
Nck2	-5920.0	1627.0
Ncstn	14410.0	-12169.0
Nell2	9389.0	7424.0
Neo1	13672.0	-8520.0
Nfasc	10990.0	-11851.0
Ngef	-11571.0	-8755.0
Nras	11707.0	-12390.0
Nrcam	13750.0	-13217.0
Nrp1	-10538.0	3551.0
Nrp2	-11608.0	12652.0
Nrtn	12494.0	-11907.0
Ntn1	-12657.0	12445.0
Ntn4	-11679.0	12792.0
Numb	-4855.0	5859.0
Pabpc2	1803.5	5051.0
Pak1	9007.0	-10571.0
Pak2	-11115.0	10419.0
Pak3	9025.0	-9081.0
Pak4	2963.0	-7078.0
Pak6	13683.0	-13884.0
Pak7	-6905.0	2039.0
Pdlim7	26.0	-7844.0
Pfn1	-2444.0	4731.0
Pfn2	14209.0	-14087.0
Pik3ca	5274.0	-12270.0
Pik3cb	-11168.0	9586.0
Pik3cd	-8249.0	9542.0
Pik3r1	-5226.0	4551.0
Pik3r2	-4478.0	11254.0
Pik3r3	13321.0	6430.0
Pip5k1c	12377.0	9141.0
Pitpna	8448.0	-7392.0
Plcg1	15140.0	-14853.0
Plxna1	9987.0	12159.0
Plxna2	7960.0	11857.0
Plxna3	8860.0	-4497.0
Plxna4	12340.0	7720.0
Plxnb1	11092.0	-4388.0
Plxnb3	9800.0	3436.0
Plxnc1	-9178.0	11460.0
Plxnd1	-12438.0	12973.0
Pmp22	-3954.0	6790.0
Pou3f1	-1704.0	-5253.0
Ppp3cb	-6472.0	4604.0
Prkaca	-8030.0	10329.0
Prkacb	-256.0	3728.0
Prkar2a	13537.0	-12751.0
Prkca	-11577.0	11021.0
Prkcq	-6737.0	3402.0
Prnp	-9879.0	-10677.0
Prx	5888.0	-3055.0
Psen1	-11531.0	9651.0
Psen2	7176.0	-5828.0
Psenen	-7498.0	6057.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Pspn	3658.0	-3853.0
Ptk2	9305.0	2859.0
Ptpn11	-3808.0	6242.0
Ptpra	-12291.0	12403.0
Ptprc	-12569.0	12780.0
Rac1	-4047.0	262.0
Ranbp9	5827.0	-10322.0
Rap1gap	12758.0	-9245.0
Rasa1	-6341.0	6192.0
Rbm8a2	-485.5	-1222.5
Rbx1	2286.0	4532.0
Rdx	-9038.0	7135.0
Reln	5678.0	-13794.0
Ret	169.0	-7826.0
Rgma	-3969.0	6866.0
Rgmb	13555.0	-12031.0
Rhob	9640.0	-12113.0
Rhoc	-10110.0	8403.0
Rnd1	-10960.0	10295.0
Rnps1	11263.0	-12563.0
Robo1	4284.0	7975.0
Robo2	-10164.0	12956.0
Robo3	-12220.0	10440.0
Rock1	4877.0	-11833.0
Rock2	7938.0	-13372.0
Rpl10a	13690.0	-14501.0
Rpl11	14091.0	-14633.0
Rpl12	15157.0	-14798.0
Rpl13	13429.0	-12580.0
Rpl14	13529.0	-14374.0
Rpl15	13474.0	-14564.0
Rpl18	14615.0	-14673.0
Rpl18a	13757.0	-13973.0
Rpl19	14722.0	-14378.0
Rpl22	11668.0	-14287.0
Rpl22l1	-2502.0	-12072.0
Rpl23	14658.0	-14919.0
Rpl23a	13760.0	-14415.0
Rpl24	-6131.0	6035.0
Rpl26	14694.0	-14843.0
Rpl27-ps3	-2109.5	3930.5
Rpl27a	14202.0	-13942.0
Rpl28	11063.0	-10345.0
Rpl29	14142.0	-14360.0
Rpl3	12981.0	-13459.0
Rpl30	11284.0	-13418.0
Rpl32	15195.0	-14957.0
Rpl34	14216.0	-14655.0
Rpl35	14822.0	-14690.0
Rpl36al	-4248.0	-11655.0
Rpl37	14582.0	-14962.0
Rpl37a	15203.0	-14541.0
Rpl38	14848.0	-14852.0
Rpl39	14758.0	-14951.0
Rpl39l	3982.0	-2768.0
Rpl3l	-10870.0	-6547.0
Rpl4	13361.0	-13875.0
Rpl41	14456.0	-14232.0
Rpl5	6086.0	-13310.0
Rpl6	14498.0	-14112.0
Rpl8	13598.0	-12652.0
Rplp0	14993.0	-13165.0
Rplp1	15259.0	-14929.0
Rplp2	13695.0	-11181.0
Rps11	15181.0	-14944.0
Rps13	13052.0	-13020.0
Rps14	12707.0	-13299.0
Rps15a	12963.0	-13765.0
Rps16	15113.0	-14800.0
Rps17	14996.0	-14975.0
Rps18	14146.0	-14208.0
Rps19	14632.0	-13971.0
Rps20	14597.0	-14678.0
Rps21	14839.0	-14698.0
Rps23	14881.0	-14689.0
Rps24	15030.0	-14883.0
Rps25	14734.0	-14632.0
Rps26	15026.0	-14729.0
Rps27	13829.0	-14647.0
Rps27a	13894.0	-14715.0
Rps27l	13961.0	-12732.0
Rps29	14692.0	-15018.0
Rps3	14361.0	-14711.0
Rps3a1	10592.0	-13421.0
Rps4x	13560.0	-13892.0
Rps5	14656.0	-14338.0
Rps6	12437.0	-12720.0
Rps6ka1	13571.0	8925.0
Rps6ka2	14482.0	-10261.0
Rps6ka3	-7830.0	5782.0
Rps6ka4	-3914.0	11808.0
Rps6ka5	45.0	2524.0
Rps6ka6	-2720.0	-6681.0
Rps7	13962.0	-14305.0
Rps8	15035.0	-14396.0
Rps9	8708.0	-12306.0
Rpsa	15188.0	-13108.0
Rras	9635.0	-13646.0
Scn11a	4094.0	4137.5
Scn1a	7990.0	-4949.0
Scn1b	12992.0	-10197.0
Scn2b	3274.0	4282.0
Scn3a	8357.0	-10682.0
Scn3b	7714.0	2635.0
Scn4a	11181.0	1624.0
Scn4b	8069.0	10612.0
Scn5a	13114.0	-14558.0
Scn7a	-8259.0	11696.0
Scn8a	14362.0	-13369.0
Sdc2	-11747.0	10378.0
Sdcbp	15153.0	-15107.0
Sema3a	11254.0	-12343.0
Sema3e	-1439.0	7677.0
Sema4a	8835.0	10255.0
Sema4d	-12323.0	13004.0
Sema5a	-3839.0	-4874.0
Sema6a	-8616.0	1774.0
Sema6d	-11742.0	9957.0
Sema7a	-369.0	4584.0
Sh3gl2	-11302.0	-5104.0
Sh3kbp1	6066.0	-2951.0
Shank3	-8064.0	11859.0
Shc1	-8826.0	9471.0
Shc3	-11316.0	8814.0
Shtn1	-11564.0	12357.0
Siah1b	-5724.0	7247.0
Siah2	-10891.0	11293.0
Slit1	10290.0	-10823.0
Slit2	-9878.0	9321.0
Slit3	12952.0	-6476.0
Smarca4	-4424.0	10551.0
Sos1	-11977.0	9665.0
Sos2	-5483.0	3046.0
Sox10	-1524.0	3549.0
Spta1	-10792.0	12612.0
Sptan1	14829.0	-14042.0
Sptb	11519.0	-178.0
Sptbn1	14290.0	-14606.0
Sptbn2	15226.0	-13965.0
Sptbn4	-5.0	-8696.0
Sptbn5	12488.0	-12972.0
Src	8646.0	4243.0
Srebf2	-4237.0	9342.0
Srgap1	9493.0	11288.0
Srgap2	10271.0	-10418.0
Srgap3	14988.0	-14259.0
St8sia2	12735.0	-13219.0
St8sia4	-11567.0	12370.0
Tead1	-3955.0	2810.0
Tiam1	13330.0	-11554.0
Tln1	-11767.0	12745.0
Trem2	14131.0	-9686.0
Trio	-9497.0	12173.0
Trpc1	-6951.0	-4789.0
Trpc3	10273.0	-9076.0
Trpc4	-6392.0	8840.0
Trpc5	-5585.0	10887.0
Trpc6	6831.0	-2979.0
Tyrobp	-4198.0	-8348.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Unc5a	-8229.0	9426.0
Unc5b	14534.0	9226.0
Unc5c	-12014.0	12328.0
Unc5d	-5359.5	-3929.0
Upf2	-8720.0	378.0
Upf3a	5838.0	9024.0
Upf3b	14206.0	-13931.0
Usp33	-8958.0	-3443.0
Utrn	13490.0	-12047.0
Vasp	-3832.0	4449.0
Vav2	-4852.0	12450.0
Vav3	14614.0	-14980.0
Vldlr	-11073.0	2870.0
Wasl	6310.0	-10820.0
Wwtr1	5283.0	-14386.0
Yap1	-7550.0	6222.0
Yes1	4717.0	-6854.0
Zswim8	12845.0	-11226.0

---

---

Separation-of-Sister-Chromatids

Separation-of-Sister-Chromatids

metric	value
setSize	167
pMANOVA	5.39e-07
p.adjustMANOVA	1.74e-05
s.dist	0.291
s.diab	0.164
s.PMX	-0.241
p.diab	0.000246
p.PMX	7.75e-08

Top 20 genes

Gene	diab	PMX
Spc25	15273	-15132
Ppp2r5a	14617	-14818
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Rps27a	13894	-14715
Rps27	13829	-14647
Dync1i2	13930	-14334
Dync1li2	13775	-14349
Psma7	13781	-14022
Ppp2cb	14291	-13381
Zwint	12999	-14462
Psmc3	13783	-13466
Anapc16	13128	-13447
Anapc5	14536	-12088
Anapc4	14276	-12248
Dsn1	12989	-13118
Psmb3	12063	-13952
Zwilch	13125	-12780
Ppp1cc	13589	-11988

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahctf1	-10865	-10185
Anapc1	-11278	10450
Anapc10	-40	-7692
Anapc11	-4767	-2276
Anapc15	-2513	-9553
Anapc16	13128	-13447
Anapc2	-3217	9388
Anapc4	14276	-12248
Anapc5	14536	-12088
Anapc7	10824	-6183
Aurkb	6296	-7654
B9d2	-5649	8837
Birc5	12522	-11275
Bub1	7301	7957
Bub1b	11232	4229
Bub3	-11165	11759
Cdc16	10625	-286
Cdc20	13126	-4714
Cdc23	180	8382
Cdc26	8205	-5823
Cdc27	-6730	-6274
Cdca5	6525	30
Cdca8	3238	-2833
Cenpa	3435	5318
Cenpc1	-3272	-8022
Cenpe	4365	-6647
Cenpf	13427	-379
Cenph	10433	-9250
Cenpi	8123	-7481
Cenpk	9317	-8016
Cenpl	-1784	-10457
Cenpm	11559	-9488
Cenpn	9068	4694
Cenpo	4588	-8699
Cenpp	5610	4078
Cenpq	-8830	-3341
Cenpt	13110	-10179
Cenpu	11737	-7832
Ckap5	-1941	9831
Clasp1	8043	-6017
Clasp2	14039	-9470
Clip1	-3196	-4018
Dsn1	12989	-13118
Dync1h1	12037	3704
Dync1i1	7564	7503
Dync1i2	13930	-14334
Dync1li1	10870	-10085
Dync1li2	13775	-14349
Dynll1	-10023	-2241
Dynll2	-12351	10871
Ercc6l	-7435	2783
Espl1	7494	-361
Hdac8	5664	-6069
Incenp	5723	-3327
Itgb3bp	4897	-8304
Kif18a	-3219	-3152
Kif2a	11818	-4454
Kif2c	10981	-8403
Kntc1	11653	-11626
Mad1l1	-2336	6065
Mad2l1	12617	-8263
Mapre1	3104	2535
Mis12	-8150	7697
Ndc80	11305	-7543
Nde1	-6074	8864
Ndel1	-6462	-13712
Nsl1	2968	2930
Nudc	9181	-10432
Nuf2	8710	-9737
Nup107	-4524	-6225
Nup133	-6405	10731
Nup160	-7196	-7326
Nup37	-4813	9951
Nup43	8894	-8868
Nup85	-9207	9918
Nup98	10837	4406
Pafah1b1	4117	-10743
Pds5a	-2274	-8133
Pds5b	-8117	11104
Plk1	9395	-5777
Pmf1	13680	-10495
Ppp1cc	13589	-11988
Ppp2ca	2443	326
Ppp2cb	14291	-13381
Ppp2r1a	11507	3755
Ppp2r1b	-3062	-7202
Ppp2r5a	14617	-14818
Ppp2r5b	-2576	4479
Ppp2r5c	12442	-9365
Ppp2r5d	11554	1834
Ppp2r5e	-4849	4842
Psma1	-6738	-7608
Psma2	2844	-13370
Psma3	9490	-12548
Psma4	4617	-12505
Psma5	5504	-11202
Psma6	9985	-12478
Psma7	13781	-14022
Psma8	-7575	7041
Psmb1	6104	-12225
Psmb10	8202	-4783
Psmb11	5872	-6129
Psmb2	7847	-11836
Psmb3	12063	-13952
Psmb4	-4466	-8497
Psmb5	10041	-10541
Psmb6	11789	-12835
Psmb7	175	-13055
Psmb8	-5795	2962
Psmb9	-3858	5687
Psmc1	11705	-6393
Psmc2	-10211	7777
Psmc3	13783	-13466
Psmc4	-7487	10029
Psmc5	5939	-5097
Psmc6	-5320	-12074
Psmd1	-4486	-6816
Psmd10	-5266	7738
Psmd11	-4239	-7981
Psmd12	-5190	-6195
Psmd13	10924	-7634
Psmd14	-9498	2769
Psmd2	-11276	10253
Psmd3	5369	146
Psmd4	8666	-10398
Psmd5	-1595	-6026
Psmd6	-1663	-8390
Psmd7	-9175	-8611
Psmd8	14709	-14720
Psmd9	14751	-14675
Psme1	14335	-14654
Psme2b	158	1873
Psme3	-3827	9126
Psme4	-4545	-7955
Psmf1	3006	8610
Pttg1	13199	-11759
Rad21	-6091	-9748
Ranbp2	-1884	-9227
Rangap1	-4113	2101
Rcc2	2405	7611
Rps27	13829	-14647
Rps27a	13894	-14715
Sec13	9849	-12486
Seh1l	9415	-7505
Sgol1	-1679	7844
Sgol2a	8718	-3548
Ska1	6709	-10296
Ska2	-9526	7541
Smc1a	3009	-11954
Smc3	9972	-12948
Spc24	13403	-11390
Spc25	15273	-15132
Spdl1	10773	-10080
Stag1	-9666	10304
Stag2	2947	-13895
Taok1	-4234	-10641
Uba52	4596	-6796
Ubb	-3411	-7959
Ube2c	9861	-8024
Ube2d1	11721	-13291
Ube2e1	-10811	7252
Ube2s	9693	-6037
Wapl	-3476	-10206
Xpo1	-10778	9680
Zw10	-5911	7531
Zwilch	13125	-12780
Zwint	12999	-14462

---

---

Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides

Transport-of-inorganic-cations/anions-and-amino-acids/oligopeptides

metric	value
setSize	103
pMANOVA	6.82e-07
p.adjustMANOVA	2.15e-05
s.dist	0.341
s.diab	0.299
s.PMX	-0.164
p.diab	1.6e-07
p.PMX	0.00392

Top 20 genes

Gene	diab	PMX
Slc38a3	15326	-15093
Slc6a12	15137	-15079
Slc26a7	14516	-14597
Slc16a10	14267	-14648
Slc43a1	14574	-14277
Slc4a7	13723	-14904
Slc7a5	14136	-14270
Slc4a8	15202	-13045
Slc38a2	13304	-14762
Slc6a20a	13553	-14488
Slc4a4	14911	-13072
Slc12a1	13037	-14012
Slc6a18	11987	-15066
Slc36a4	13705	-12774
Slc8b1	13408	-12709
Slc6a6	12104	-13979
Slc15a4	12562	-13195
Slc38a1	13424	-11911
Sri	12407	-12509
Slc7a3	11889	-12704

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcyl2	-3998.0	10444.0
Calm1	152.0	-11443.0
Ctns	12438.0	-3307.0
Gm21985	876.5	853.5
Slc12a1	13037.0	-14012.0
Slc12a2	-9543.0	5308.0
Slc12a3	4130.0	12270.0
Slc12a4	12772.0	-10222.0
Slc12a5	-12139.0	11709.0
Slc12a7	-10959.0	12246.0
Slc15a1	14629.0	-5690.0
Slc15a2	-5683.0	-11579.0
Slc15a3	-10055.0	10157.0
Slc15a4	12562.0	-13195.0
Slc16a10	14267.0	-14648.0
Slc17a1	-11630.0	-13474.0
Slc17a5	8179.0	-11085.0
Slc17a7	7796.0	-2453.0
Slc17a8	-1488.0	-9452.0
Slc1a1	-11293.0	11806.0
Slc1a2	-12370.0	11787.0
Slc1a3	12738.0	-9096.0
Slc1a4	-9777.0	-9552.0
Slc1a5	12430.0	-11060.0
Slc1a6	3402.0	-9908.0
Slc1a7	4374.0	-8891.0
Slc20a1	8114.0	-10840.0
Slc20a2	13344.0	-11305.0
Slc24a2	-2109.5	2317.5
Slc24a3	10439.0	-10915.0
Slc24a4	-950.0	4396.0
Slc24a5	11163.0	-11870.0
Slc25a10	4794.0	-10546.0
Slc25a18	11994.0	-11625.0
Slc25a22	5438.0	-12714.0
Slc25a26	7069.0	-10769.0
Slc25a29	4534.0	-47.0
Slc26a1	-12048.0	12878.0
Slc26a11	10568.0	-8842.0
Slc26a2	-9372.0	2909.0
Slc26a3	9067.0	-6589.0
Slc26a4	5973.0	12048.0
Slc26a6	13997.0	-7740.0
Slc26a7	14516.0	-14597.0
Slc26a9	-3389.5	7224.0
Slc34a1	-12261.0	12443.0
Slc34a2	10221.0	-13190.0
Slc34a3	-8611.0	10421.0
Slc36a1	-12104.0	12974.0
Slc36a2	-2526.0	8786.0
Slc36a4	13705.0	-12774.0
Slc38a1	13424.0	-11911.0
Slc38a2	13304.0	-14762.0
Slc38a3	15326.0	-15093.0
Slc38a4	-10463.0	6593.0
Slc38a5	5226.5	-3205.0
Slc3a1	-9683.0	-7581.0
Slc3a2	12234.0	-4863.0
Slc43a1	14574.0	-14277.0
Slc43a2	14957.0	11408.0
Slc4a1	14778.0	8982.0
Slc4a10	-4629.0	7874.5
Slc4a2	11101.0	9303.0
Slc4a3	14179.0	4427.0
Slc4a4	14911.0	-13072.0
Slc4a5	12171.0	-5339.0
Slc4a7	13723.0	-14904.0
Slc4a8	15202.0	-13045.0
Slc4a9	13258.0	9326.0
Slc5a12	13064.0	-4499.0
Slc5a5	8692.0	-4531.0
Slc5a8	9361.0	-14435.0
Slc6a12	15137.0	-15079.0
Slc6a14	7456.0	-4867.0
Slc6a15	-12582.0	7930.0
Slc6a18	11987.0	-15066.0
Slc6a19	14720.0	-6686.0
Slc6a20a	13553.0	-14488.0
Slc6a6	12104.0	-13979.0
Slc7a1	13062.0	-10984.0
Slc7a10	7075.0	-7559.0
Slc7a11	11318.0	-11511.0
Slc7a2	-1409.0	7732.0
Slc7a3	11889.0	-12704.0
Slc7a5	14136.0	-14270.0
Slc7a6	12977.0	-8707.0
Slc7a7	9157.0	5962.0
Slc7a8	13603.0	2754.0
Slc7a9	10955.0	-10703.0
Slc8a1	10895.0	12733.0
Slc8a2	8883.0	8477.0
Slc8a3	13077.0	-11111.0
Slc8b1	13408.0	-12709.0
Slc9a1	11956.0	-5779.0
Slc9a2	7774.0	-10864.0
Slc9a3	-10359.0	12862.0
Slc9a4	13389.0	5319.0
Slc9a5	-6331.0	11412.0
Slc9a6	-1552.0	-4571.0
Slc9a7	9669.0	-4563.0
Slc9a8	-12764.0	12958.0
Slc9a9	-358.0	7295.0
Sri	12407.0	-12509.0

---

---

Bicarbonate-transporters

Bicarbonate-transporters

metric	value
setSize	10
pMANOVA	1.09e-06
p.adjustMANOVA	3.36e-05
s.dist	0.631
s.diab	0.622
s.PMX	0.104
p.diab	0.000655
p.PMX	0.569

Top 20 genes

Gene	diab	PMX
Slc4a1	14778	8982
Slc4a9	13258	9326
Slc4a2	11101	9303
Slc4a3	14179	4427

Click HERE to show all gene set members

All member genes

	diab	PMX
Ahcyl2	-3998	10444.0
Slc4a1	14778	8982.0
Slc4a10	-4629	7874.5
Slc4a2	11101	9303.0
Slc4a3	14179	4427.0
Slc4a4	14911	-13072.0
Slc4a5	12171	-5339.0
Slc4a7	13723	-14904.0
Slc4a8	15202	-13045.0
Slc4a9	13258	9326.0

---

---

Transport-of-small-molecules

Transport-of-small-molecules

metric	value
setSize	677
pMANOVA	1.16e-06
p.adjustMANOVA	3.51e-05
s.dist	0.145
s.diab	0.117
s.PMX	-0.0857
p.diab	1.82e-07
p.PMX	0.000135

Top 20 genes

Gene	diab	PMX
Angptl3	15388	-15148
Slc5a10	15375	-15134
Slc25a4	15363	-15098
Slc25a5	15369	-15070
Clcnka	15331	-15102
Atp1a1	15329	-15091
Slc38a3	15326	-15093
Cp	15213	-15114
Atp1b1	15270	-15047
Slc6a12	15137	-15079
Aqp2	15330	-14826
Nipal1	15014	-15042
Mylip	15001	-14993
Car2	15260	-14732
Pcsk9	14990	-14996
Apoc3	14994	-14912
Atp13a4	15075	-14827
Abcc3	15114	-14788
Atp6v0e	14931	-14952
Slc6a13	14786	-15051

Click HERE to show all gene set members

All member genes

	diab	PMX
A2m	-11340.0	9422.0
Abca1	13450.0	-12955.0
Abca12	5962.5	-6264.5
Abca2	15172.0	-13643.0
Abca3	-13.0	3624.0
Abca4	6691.0	-13850.0
Abca5	13983.0	-11374.0
Abca6	12400.0	-12570.0
Abca7	14641.0	-13079.0
Abca8b	14668.0	-13449.0
Abca9	-9619.0	11871.0
Abcb10	-10377.0	11753.0
Abcb1a	-11333.0	10692.0
Abcb4	-2352.0	-7194.0
Abcb5	6047.0	-5293.0
Abcb6	-1585.0	6088.0
Abcb7	-6221.0	-11664.0
Abcb8	-1594.0	8076.0
Abcb9	9960.0	8803.0
Abcc2	11196.0	-3540.0
Abcc3	15114.0	-14788.0
Abcc4	15176.0	1184.0
Abcc5	6103.0	7523.0
Abcc6	-10204.0	11837.0
Abcc9	-11661.0	10701.0
Abcd1	-8201.0	4179.0
Abcd2	8445.0	-9230.0
Abcd3	-7752.0	-11300.0
Abcf1	-939.0	381.0
Abcg1	4125.0	-8928.0
Abcg3	-10478.0	10531.0
Abcg4	4122.0	-7472.0
Abcg5	9938.0	-8026.0
Abcg8	-11.0	9541.0
Aco1	11986.0	-12026.0
Adcy1	-9688.0	10111.0
Adcy2	10325.0	-11711.0
Adcy3	-9740.0	12419.0
Adcy4	-7538.0	10359.0
Adcy5	5265.0	12483.0
Adcy6	12805.0	-11480.0
Adcy7	-11420.0	12113.0
Adcy8	-5867.0	1557.0
Adcy9	-9790.0	11763.0
Add1	-10711.0	8903.0
Add2	11798.0	2818.0
Add3	-10934.0	12737.0
Afg3l2	11582.0	-5327.0
Ahcyl2	-3998.0	10444.0
Akap1	10140.0	-11620.0
Alad	-10369.0	10115.0
Alb	-5186.0	-12238.0
Amn	-9599.0	11264.0
Angptl3	15388.0	-15148.0
Angptl4	8449.0	-14576.0
Angptl8	14423.0	-13182.0
Ank	-9965.0	11061.0
Ano1	-6646.0	11672.0
Ano10	14497.0	-10908.0
Ano2	-5297.0	5752.0
Ano3	15020.0	-14380.0
Ano4	13655.0	-13262.0
Ano5	-5027.0	10651.0
Ano6	-8051.0	10904.0
Ano7	-2943.0	-2073.5
Ano8	7029.0	11575.0
Ano9	14626.0	-14425.0
Ap2a1	9324.0	5186.0
Ap2a2	-8561.0	11221.0
Ap2b1	-9075.0	10334.0
Ap2m1	11298.0	-6224.0
Ap2s1	11182.0	-5073.0
Apoa1	-4915.0	-14116.0
Apoa2	14354.0	-14888.0
Apoa4	-1360.0	-13303.0
Apoa5	-1213.0	-11084.0
Apob	14399.0	-9778.0
Apobr	-5584.0	-4234.0
Apoc1	9056.0	-13594.0
Apoc3	14994.0	-14912.0
Apoc4	-2531.0	-1222.5
Apod	13944.0	-13145.0
Apoe	14840.0	-14885.0
Apof	2383.5	-2384.0
Aqp1	8685.0	-12918.0
Aqp11	-11281.0	5054.0
Aqp12	1803.5	-1222.5
Aqp2	15330.0	-14826.0
Aqp3	14631.0	-11627.0
Aqp4	13365.0	-14761.0
Aqp5	7223.0	-10945.0
Aqp6	14921.0	-6555.0
Aqp7	12277.0	-4384.0
Aqp8	13473.0	8867.0
Aqp9	-1955.0	-96.0
Arl2bp	13925.0	-12872.0
Asic1	4570.0	4100.0
Asic2	11272.0	-6067.0
Asic3	13063.0	-12983.0
Asic4	2517.0	9770.0
Asic5	12038.0	-13122.0
Asph	14868.0	-10498.0
Atp10a	6732.0	6850.0
Atp10b	14389.0	1602.0
Atp10d	-11585.0	10455.0
Atp11a	-12354.0	11119.0
Atp11b	13104.0	-14661.0
Atp11c	-7165.0	-4858.0
Atp12a	14693.0	-13086.0
Atp13a1	-5438.0	8064.0
Atp13a2	5750.0	11413.0
Atp13a4	15075.0	-14827.0
Atp13a5	4094.0	-4251.0
Atp1a1	15329.0	-15091.0
Atp1a2	-11450.0	12843.0
Atp1a3	156.0	6565.0
Atp1a4	-3227.0	3852.5
Atp1b1	15270.0	-15047.0
Atp1b2	-10533.0	11952.0
Atp1b3	9790.0	-13383.0
Atp2a1	7434.0	-9596.0
Atp2a2	-8496.0	5103.0
Atp2a3	13296.0	-8272.0
Atp2b1	-1035.0	-10412.0
Atp2b2	-9825.0	12073.0
Atp2b3	-2739.0	-1222.5
Atp2b4	14526.0	11906.0
Atp2c1	-10376.0	6936.0
Atp2c2	14695.0	-14840.0
Atp4a	10523.0	11730.0
Atp6ap1	7214.0	2925.0
Atp6v0a1	8644.0	-4832.0
Atp6v0a2	-3899.0	-7579.0
Atp6v0a4	15332.0	-14499.0
Atp6v0b	4840.0	2125.0
Atp6v0c	3151.0	-10611.0
Atp6v0d1	203.0	1912.0
Atp6v0d2	15150.0	-3904.0
Atp6v0e	14931.0	-14952.0
Atp6v0e2	7872.0	6422.0
Atp6v1a	10227.0	-7433.0
Atp6v1b1	13172.0	12006.0
Atp6v1b2	-7304.0	5553.0
Atp6v1c1	12161.0	-10561.0
Atp6v1c2	14305.0	9508.0
Atp6v1d	12172.0	-14697.0
Atp6v1e1	13351.0	-11187.0
Atp6v1f	14121.0	-13473.0
Atp6v1g1	15089.0	-12782.0
Atp6v1g2	-3055.0	4701.0
Atp6v1g3	14162.0	-9021.0
Atp6v1h	9566.0	-8530.0
Atp7a	14760.0	-13906.0
Atp7b	-10796.0	2779.0
Atp8a1	6168.0	-5849.0
Atp8a2	4721.0	1353.0
Atp8b1	11100.0	-5622.0
Atp8b2	-9832.0	8629.0
Atp8b3	8520.5	-7611.0
Atp8b4	-12567.0	8273.0
Atp9a	-6057.0	8712.0
Atp9b	7035.0	14.0
Avpr2	13885.0	-7825.0
Azgp1	-12716.0	12829.0
Best1	-10167.0	9636.0
Best2	-3527.0	5890.0
Best3	13186.0	-8610.0
Bmp1	14580.0	-13984.0
Bsg	10831.0	-9772.0
Bsnd	-7804.0	12651.0
Calm1	152.0	-11443.0
Camk2a	-8582.0	9297.0
Camk2b	12864.0	-14402.0
Camk2d	14624.0	-13868.0
Camk2g	-9180.0	8979.0
Cand1	-11015.0	10321.0
Car1	-3167.5	2317.5
Car2	15260.0	-14732.0
Car4	-12743.0	11263.0
Ccdc109b	4551.0	-12246.0
Ces3a	-8795.0	5335.0
Cftr	-7713.0	-8439.0
Cidec	10906.0	-12016.0
Clca1	4094.0	-4251.0
Clca2	-4679.5	8091.0
Clca4b	-2109.5	2317.5
Clcn1	11915.0	-9619.0
Clcn2	6024.0	-3161.0
Clcn3	-12390.0	8666.0
Clcn4	-12440.0	8743.0
Clcn5	10105.0	-6296.0
Clcn6	4525.0	10762.0
Clcn7	9462.0	-4788.0
Clcnka	15331.0	-15102.0
Clta	-6346.0	5123.0
Cltc	8328.0	-9844.0
Cp	15213.0	-15114.0
Creb3l3	2849.0	-10313.0
Ctns	12438.0	-3307.0
Cubn	12176.0	-12708.0
Cul1	114.0	-11623.0
Cutc	-8224.0	6963.0
Cyb5r1	3016.0	-7267.0
Cyb5r2	8823.0	-8687.0
Cyb5r4	-6287.0	2074.0
Cyb5rl	14541.0	7984.0
Cybrd1	6084.0	-10658.0
Cygb	-7743.0	10602.0
Derl1	-5820.0	-8046.0
Derl2	-11301.0	10288.0
Derl3	-10623.0	97.0
Dmtn	-3087.0	12298.0
Eif2s1	3692.0	-6086.0
Eif2s2	11201.0	-14019.0
Eif2s3x	4982.0	-5754.0
Emb	15048.0	-13070.0
Erlec1	-5530.0	4502.0
Erlin1	-11061.0	11033.0
Erlin2	-11267.0	6567.0
Fbxl5	-10672.0	4244.0
Fgf21	4015.5	5482.0
Fkbp1b	-10268.0	8412.0
Fth1	14612.0	-13244.0
Ftl1	-7242.0	9787.0
Furin	-1107.0	-210.0
Fxyd1	-7377.0	9606.0
Fxyd2	-5577.0	-12198.0
Fxyd3	6682.5	2778.0
Fxyd4	14187.0	-14477.0
Fxyd6	11278.0	-8487.0
Fxyd7	-3913.0	4945.0
Glrx3	15275.0	-13221.0
Gm21985	876.5	853.5
Gm28035	3834.0	-8527.0
Gnas	-3961.0	-3188.0
Gnb1	14052.0	-12910.0
Gnb2	8485.0	9301.0
Gnb3	-2490.5	742.0
Gnb4	-1201.0	-6056.0
Gnb5	13333.0	-11130.0
Gng10	2409.0	6218.0
Gng11	-3886.0	7951.0
Gng12	6244.0	-14594.0
Gng2	10797.0	-7497.0
Gng3	-4926.0	7095.0
Gng4	7213.0	10712.0
Gng5	4656.0	-12487.0
Gng7	-3080.0	9870.0
Gng8	-4369.0	8851.0
Gngt1	1803.5	-1222.5
Gngt2	-1659.0	-5045.0
Gpihbp1	-10437.0	11549.0
Hba-a1	-10905.0	11866.0
Hbb-bt	-9874.0	11776.0
Hdlbp	-8098.0	-9758.0
Heph	4225.0	3531.0
Hfe	15274.0	-9071.0
Hmox1	-10213.0	8284.0
Hmox2	-1185.0	6463.0
Ireb2	-10439.0	1324.0
Kcnj11	-406.0	8525.0
Lcat	-6666.0	-5308.0
Lcn12	2512.5	-2558.5
Lcn2	14998.0	-14767.0
Ldlr	10618.0	-7930.0
Ldlrap1	-10393.0	10217.0
Letm1	-9063.0	10500.0
Lipa	347.0	3473.0
Lipc	9378.0	-10189.0
Lipg	13307.0	-13357.0
Lmf1	12914.0	-13099.0
Lmf2	11150.0	-9445.0
Lpl	-12663.0	12811.0
Lrrc8b	-5049.0	2510.0
Lrrc8c	11238.0	1169.0
Lrrc8d	-9628.0	10729.0
Lrrc8e	13137.0	-12227.0
Lsr	-6353.0	-10021.0
Magt1	-9267.0	1797.0
Mb	-7962.0	-3401.0
Mbtps1	-10920.0	7056.0
Mbtps2	-4990.0	8254.0
Mcoln1	5013.0	7399.0
Mcoln2	12057.0	-13831.0
Mcoln3	14908.0	-13736.0
Mcu	13857.0	-7363.0
Mfsd4b4	-10812.0	11216.0
Mfsd7b	13756.0	-14707.0
Micu1	-5471.0	11645.0
Micu2	-9469.0	11804.0
Micu3	-2563.0	-11489.0
Mmgt1	5194.0	-9854.0
Mrs2	-10469.0	10228.0
Mttp	-9985.0	2027.0
Mylip	15001.0	-14993.0
Myo5b	-7101.0	-7875.0
Nalcn	12364.0	-8781.0
Nceh1	-9414.0	-11062.0
Nedd4l	11295.0	-14092.0
Nedd8	3348.0	-12551.0
Ngb	4127.0	-3485.0
Nipa1	9244.0	-4439.0
Nipa2	-5012.0	-6767.0
Nipal1	15014.0	-15042.0
Nipal2	14966.0	-8619.0
Nipal3	-1735.0	11968.0
Nipal4	6453.0	-8440.0
Npc1	12742.0	-8012.0
Npc2	13953.0	-13007.0
Nr1h2	6078.0	4986.0
Nr1h3	-10153.0	10155.0
Os9	-9678.0	5744.0
Ostm1	12347.0	-11828.0
P4hb	-11855.0	7508.0
Parl	10487.0	7403.0
Pcsk5	-5180.0	-9727.0
Pcsk6	14649.0	-14753.0
Pcsk9	14990.0	-14996.0
Pdzd11	-6450.0	2974.0
Pex19	8971.0	-11963.0
Pex3	9807.0	-13174.0
Phb	11520.0	-9924.0
Phb2	400.0	8485.0
Pip	4195.5	-4320.5
Plg	-5865.0	5097.0
Pln	-4956.0	12078.0
Pltp	-3269.0	8049.0
Pmpca	-8282.0	7859.0
Pmpcb	-11690.0	9128.0
Prkaca	-8030.0	10329.0
Prkacb	-256.0	3728.0
Prkar1a	12224.0	-10675.0
Prkar1b	12793.0	4753.0
Prkar2a	13537.0	-12751.0
Prkar2b	-11024.0	2146.0
Psma1	-6738.0	-7608.0
Psma2	2844.0	-13370.0
Psma3	9490.0	-12548.0
Psma4	4617.0	-12505.0
Psma5	5504.0	-11202.0
Psma6	9985.0	-12478.0
Psma7	13781.0	-14022.0
Psma8	-7575.0	7041.0
Psmb1	6104.0	-12225.0
Psmb10	8202.0	-4783.0
Psmb11	5872.0	-6129.0
Psmb2	7847.0	-11836.0
Psmb3	12063.0	-13952.0
Psmb4	-4466.0	-8497.0
Psmb5	10041.0	-10541.0
Psmb6	11789.0	-12835.0
Psmb7	175.0	-13055.0
Psmb8	-5795.0	2962.0
Psmb9	-3858.0	5687.0
Psmc1	11705.0	-6393.0
Psmc2	-10211.0	7777.0
Psmc3	13783.0	-13466.0
Psmc4	-7487.0	10029.0
Psmc5	5939.0	-5097.0
Psmc6	-5320.0	-12074.0
Psmd1	-4486.0	-6816.0
Psmd10	-5266.0	7738.0
Psmd11	-4239.0	-7981.0
Psmd12	-5190.0	-6195.0
Psmd13	10924.0	-7634.0
Psmd14	-9498.0	2769.0
Psmd2	-11276.0	10253.0
Psmd3	5369.0	146.0
Psmd4	8666.0	-10398.0
Psmd5	-1595.0	-6026.0
Psmd6	-1663.0	-8390.0
Psmd7	-9175.0	-8611.0
Psmd8	14709.0	-14720.0
Psmd9	14751.0	-14675.0
Psme1	14335.0	-14654.0
Psme2b	158.0	1873.0
Psme3	-3827.0	9126.0
Psme4	-4545.0	-7955.0
Psmf1	3006.0	8610.0
Rab11a	5029.0	-8221.0
Rab11fip2	-8702.0	-300.0
Raf1	-10208.0	10796.0
Rhag	-2109.5	6247.0
Rhbg	8656.0	12497.0
Rhcg	13609.0	2950.0
Rnf185	5654.0	8045.0
Rnf5	-9239.0	-3332.0
Rps27a	13894.0	-14715.0
Runx1	-8565.0	3304.0
Ryr1	-5087.0	8615.0
Ryr2	-12616.0	9950.0
Ryr3	5642.0	-3172.0
Sar1b	2357.0	-12462.0
Scarb1	11378.0	4436.0
Scnn1a	14690.0	-8748.0
Scnn1b	14548.0	8042.0
Scnn1g	14166.0	8691.0
Sel1l	-10789.0	7839.0
Sgk1	14467.0	-15065.0
Sgk2	-4525.0	12091.0
Sgk3	-7293.0	-2896.0
Skp1a	-9392.0	1413.0
Slc10a6	13937.0	-13433.0
Slc11a1	-7489.0	8888.0
Slc11a2	-12376.0	12870.0
Slc12a1	13037.0	-14012.0
Slc12a2	-9543.0	5308.0
Slc12a3	4130.0	12270.0
Slc12a4	12772.0	-10222.0
Slc12a5	-12139.0	11709.0
Slc12a7	-10959.0	12246.0
Slc13a1	11593.0	-7885.0
Slc13a2	14742.0	-14497.0
Slc13a3	-7838.0	-8214.0
Slc13a4	13163.0	-13331.0
Slc13a5	-12407.0	12576.0
Slc14a1	14736.0	-14810.0
Slc14a2	14264.0	-14228.0
Slc15a1	14629.0	-5690.0
Slc15a2	-5683.0	-11579.0
Slc15a3	-10055.0	10157.0
Slc15a4	12562.0	-13195.0
Slc16a1	14346.0	-8035.0
Slc16a10	14267.0	-14648.0
Slc16a2	-12591.0	12481.0
Slc16a3	11553.0	-11018.0
Slc16a7	14222.0	-9487.0
Slc16a8	11805.0	-13519.0
Slc17a1	-11630.0	-13474.0
Slc17a3	-12136.0	9781.0
Slc17a5	8179.0	-11085.0
Slc17a7	7796.0	-2453.0
Slc17a8	-1488.0	-9452.0
Slc18a1	-7855.0	-11231.0
Slc18a2	6956.0	4529.0
Slc1a1	-11293.0	11806.0
Slc1a2	-12370.0	11787.0
Slc1a3	12738.0	-9096.0
Slc1a4	-9777.0	-9552.0
Slc1a5	12430.0	-11060.0
Slc1a6	3402.0	-9908.0
Slc1a7	4374.0	-8891.0
Slc20a1	8114.0	-10840.0
Slc20a2	13344.0	-11305.0
Slc22a1	5036.0	4679.0
Slc22a12	-12706.0	12935.0
Slc22a15	11185.0	-9803.0
Slc22a17	-12227.0	12189.0
Slc22a18	-12514.0	12484.0
Slc22a2	-12013.0	9585.0
Slc22a3	13467.0	4674.0
Slc22a4	-11447.0	12036.0
Slc22a5	-8530.0	5749.0
Slc22a6	-10040.0	7803.0
Slc22a7	-12175.0	11480.0
Slc22a8	-10810.0	8065.0
Slc24a2	-2109.5	2317.5
Slc24a3	10439.0	-10915.0
Slc24a4	-950.0	4396.0
Slc24a5	11163.0	-11870.0
Slc25a10	4794.0	-10546.0
Slc25a18	11994.0	-11625.0
Slc25a22	5438.0	-12714.0
Slc25a26	7069.0	-10769.0
Slc25a29	4534.0	-47.0
Slc25a4	15363.0	-15098.0
Slc25a5	15369.0	-15070.0
Slc26a1	-12048.0	12878.0
Slc26a11	10568.0	-8842.0
Slc26a2	-9372.0	2909.0
Slc26a3	9067.0	-6589.0
Slc26a4	5973.0	12048.0
Slc26a6	13997.0	-7740.0
Slc26a7	14516.0	-14597.0
Slc26a9	-3389.5	7224.0
Slc27a1	14396.0	-13771.0
Slc27a4	-3784.0	5831.0
Slc27a6	-6969.0	3032.0
Slc28a1	138.0	-10729.0
Slc28a2	-8286.0	11816.0
Slc28a3	1803.5	3262.5
Slc29a1	-820.0	8511.0
Slc29a2	6906.0	-4413.0
Slc29a3	-5345.0	11917.0
Slc29a4	7802.0	-11391.0
Slc2a1	13277.0	-7613.0
Slc2a10	-3068.0	10733.0
Slc2a12	-10782.0	12997.0
Slc2a13	6947.0	-13339.0
Slc2a2	14424.0	-9637.0
Slc2a3	-9664.0	4925.0
Slc2a4	14237.0	-5241.0
Slc2a6	13569.0	-8321.0
Slc2a7	-9672.0	9270.0
Slc2a8	14282.0	-10018.0
Slc2a9	14060.0	8189.0
Slc30a1	-10468.0	-8215.0
Slc30a10	4317.0	-7736.0
Slc30a2	-9528.0	6295.0
Slc30a3	3944.0	-4106.0
Slc30a5	-11865.0	9045.0
Slc30a6	8816.0	-12191.0
Slc30a7	-5663.0	380.0
Slc30a8	11258.0	-12524.0
Slc31a1	-2591.0	-11933.0
Slc33a1	-11637.0	10504.0
Slc34a1	-12261.0	12443.0
Slc34a2	10221.0	-13190.0
Slc34a3	-8611.0	10421.0
Slc35a1	-10374.0	9336.0
Slc35a2	-5977.0	3482.0
Slc35a3	-7589.0	-12416.0
Slc35b2	-8665.0	8387.0
Slc35b3	12182.0	-12724.0
Slc35b4	12330.0	-14292.0
Slc35c1	-5071.0	4672.0
Slc35d1	12156.0	-14255.0
Slc35d2	-7802.0	5124.0
Slc36a1	-12104.0	12974.0
Slc36a2	-2526.0	8786.0
Slc36a4	13705.0	-12774.0
Slc38a1	13424.0	-11911.0
Slc38a2	13304.0	-14762.0
Slc38a3	15326.0	-15093.0
Slc38a4	-10463.0	6593.0
Slc38a5	5226.5	-3205.0
Slc39a1	-5074.0	-6459.0
Slc39a10	-11798.0	12584.0
Slc39a14	13890.0	-14958.0
Slc39a2	-4078.0	272.0
Slc39a3	-10008.0	12231.0
Slc39a4	12370.0	-10365.0
Slc39a5	14593.0	-15031.0
Slc39a6	13819.0	-11131.0
Slc39a7	-3889.0	379.0
Slc39a8	-5028.0	-14333.0
Slc3a1	-9683.0	-7581.0
Slc3a2	12234.0	-4863.0
Slc40a1	13621.0	-7450.0
Slc41a1	13239.0	-8902.0
Slc41a2	13323.0	-14236.0
Slc43a1	14574.0	-14277.0
Slc43a2	14957.0	11408.0
Slc44a1	-6813.0	1668.0
Slc44a2	13092.0	9189.0
Slc44a3	14832.0	-140.0
Slc44a4	-12183.0	11751.0
Slc44a5	242.0	-7344.0
Slc45a3	13451.0	-14849.0
Slc46a1	-8716.0	4783.0
Slc47a1	-12587.0	12077.0
Slc4a1	14778.0	8982.0
Slc4a10	-4629.0	7874.5
Slc4a2	11101.0	9303.0
Slc4a3	14179.0	4427.0
Slc4a4	14911.0	-13072.0
Slc4a5	12171.0	-5339.0
Slc4a7	13723.0	-14904.0
Slc4a8	15202.0	-13045.0
Slc4a9	13258.0	9326.0
Slc50a1	7525.0	5000.0
Slc5a1	14852.0	-14889.0
Slc5a10	15375.0	-15134.0
Slc5a11	15129.0	-14242.0
Slc5a12	13064.0	-4499.0
Slc5a2	-10343.0	12080.0
Slc5a3	10425.0	-14381.0
Slc5a4b	-7674.0	2838.0
Slc5a5	8692.0	-4531.0
Slc5a6	8073.0	9275.0
Slc5a8	9361.0	-14435.0
Slc5a9	12846.0	1302.0
Slc6a11	1803.5	-2073.5
Slc6a12	15137.0	-15079.0
Slc6a13	14786.0	-15051.0
Slc6a14	7456.0	-4867.0
Slc6a15	-12582.0	7930.0
Slc6a18	11987.0	-15066.0
Slc6a19	14720.0	-6686.0
Slc6a2	1803.5	637.5
Slc6a20a	13553.0	-14488.0
Slc6a3	2383.5	1282.0
Slc6a5	14419.0	-14513.0
Slc6a6	12104.0	-13979.0
Slc6a7	10389.0	-11196.0
Slc6a9	-9699.0	-10470.0
Slc7a1	13062.0	-10984.0
Slc7a10	7075.0	-7559.0
Slc7a11	11318.0	-11511.0
Slc7a2	-1409.0	7732.0
Slc7a3	11889.0	-12704.0
Slc7a5	14136.0	-14270.0
Slc7a6	12977.0	-8707.0
Slc7a7	9157.0	5962.0
Slc7a8	13603.0	2754.0
Slc7a9	10955.0	-10703.0
Slc8a1	10895.0	12733.0
Slc8a2	8883.0	8477.0
Slc8a3	13077.0	-11111.0
Slc8b1	13408.0	-12709.0
Slc9a1	11956.0	-5779.0
Slc9a2	7774.0	-10864.0
Slc9a3	-10359.0	12862.0
Slc9a4	13389.0	5319.0
Slc9a5	-6331.0	11412.0
Slc9a6	-1552.0	-4571.0
Slc9a7	9669.0	-4563.0
Slc9a8	-12764.0	12958.0
Slc9a9	-358.0	7295.0
Slc9b1	11349.0	-10055.0
Slc9b2	10920.0	-7956.0
Slco1a1	-11393.0	10971.0
Slco1b2	-5651.0	10208.0
Slco1c1	4304.0	-8804.0
Slco2a1	15225.0	-14531.0
Slco2b1	-4473.0	12205.0
Slco3a1	-12549.0	9474.0
Slco4a1	15218.0	-14085.0
Slco4c1	3264.0	-13645.0
Smdt1	13118.0	-9300.0
Soat1	-10445.0	4897.0
Soat2	6541.0	6622.0
Spg7	-3755.0	-4668.0
Sri	12407.0	-12509.0
Steap2	9887.0	-13384.0
Steap3	-11527.0	9153.0
Stom	12517.0	-9869.0
Stoml2	-5881.0	-5080.0
Stoml3	-291.0	-5967.0
Tcirg1	-10070.0	11128.0
Tfr2	13284.0	-11447.0
Tfrc	-6787.0	6449.0
Tpcn1	-10142.0	11915.0
Tpcn2	13203.0	-6818.0
Trdn	-10470.0	10096.0
Trpa1	876.5	-1222.5
Trpc1	-6951.0	-4789.0
Trpc3	10273.0	-9076.0
Trpc4	-6392.0	8840.0
Trpc4ap	7349.0	2894.0
Trpc5	-5585.0	10887.0
Trpc6	6831.0	-2979.0
Trpm1	11426.0	-11742.0
Trpm2	-10909.0	10172.0
Trpm3	14838.0	-11739.0
Trpm4	13796.0	-10685.0
Trpm5	11164.0	-10651.0
Trpm6	14929.0	44.0
Trpm7	11984.0	-10066.0
Trpm8	11921.0	-9153.0
Trpv1	-7444.0	5701.0
Trpv2	-8461.0	11896.0
Trpv3	10609.0	-12369.0
Trpv4	-10161.0	9435.0
Trpv5	14650.0	5808.0
Trpv6	13566.0	-9491.0
Tsc22d3	11831.0	-15069.0
Ttyh1	-10815.0	10702.0
Ttyh2	-5397.0	10338.0
Ttyh3	13483.0	-11529.0
Tusc3	-10949.0	7474.0
Uba52	4596.0	-6796.0
Ubb	-3411.0	-7959.0
Unc79	10784.0	-6903.0
Unc80	11709.0	7333.0
Vcp	-10725.0	9038.0
Vdac1	2808.0	-11375.0
Vdac2	13261.0	-10233.0
Vdac3	-1627.0	-11100.0
Vldlr	-11073.0	2870.0
Wnk1	13335.0	11026.0
Wnk2	8206.0	-103.0
Wnk3	12524.0	-13817.0
Wnk4	13762.0	-4931.0
Wwp1	-12213.0	11633.0
Yme1l1	-6595.0	350.0
Zdhhc8	-1923.0	-9256.0

---

---

Phosphorylation-of-CD3-and-TCR-zeta-chains

Phosphorylation-of-CD3-and-TCR-zeta-chains

metric	value
setSize	17
pMANOVA	1.36e-06
p.adjustMANOVA	4.02e-05
s.dist	0.896
s.diab	-0.523
s.PMX	0.727
p.diab	0.000186
p.PMX	2.08e-07

Top 20 genes

Gene	diab	PMX
Ptprc	-12569	12780
H2-Eb1	-11506	12142
Csk	-11205	12433
H2-Aa	-11619	11020
Pag1	-9371	12012
Cd3d	-9851	9288
Lck	-8490	10472
Cd3g	-9324	8029
Cd247	-6082	11572
Cd3e	-8888	6762
H2-Ab1	-9278	6360
Ptpn22	-5781	6555
Cd4	-2373	10589
Trbc1	-351	11521
Trac	-164	8877

Click HERE to show all gene set members

All member genes

	diab	PMX
Cd247	-6082.0	11572
Cd3d	-9851.0	9288
Cd3e	-8888.0	6762
Cd3g	-9324.0	8029
Cd4	-2373.0	10589
Csk	-11205.0	12433
H2-Aa	-11619.0	11020
H2-Ab1	-9278.0	6360
H2-Eb1	-11506.0	12142
Lck	-8490.0	10472
Pag1	-9371.0	12012
Ptpn22	-5781.0	6555
Ptprc	-12569.0	12780
Ptprj	12888.0	141
Trac	-164.0	8877
Trbc1	-351.0	11521
Trbv15	876.5	5383

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.1 (2021-08-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/liblapack.so.3
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.1               GGally_2.1.2               
##  [3] ggplot2_3.3.5               reshape2_1.4.4             
##  [5] beeswarm_0.4.0              gplots_3.1.1               
##  [7] gtools_3.9.2                tibble_3.1.4               
##  [9] echarts4r_0.4.1             kableExtra_1.3.4           
## [11] dplyr_1.0.7                 mitch_1.5.1                
## [13] DESeq2_1.32.0               SummarizedExperiment_1.22.0
## [15] Biobase_2.52.0              MatrixGenerics_1.4.3       
## [17] matrixStats_0.60.1          GenomicRanges_1.44.0       
## [19] GenomeInfoDb_1.28.4         IRanges_2.26.0             
## [21] S4Vectors_0.30.0            BiocGenerics_0.38.0        
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_2.0-2       ellipsis_0.3.2         rprojroot_2.0.2       
##  [4] XVector_0.32.0         rstudioapi_0.13        farver_2.1.0          
##  [7] bit64_4.0.5            AnnotationDbi_1.54.1   fansi_0.5.0           
## [10] xml2_1.3.2             splines_4.1.1          cachem_1.0.6          
## [13] geneplotter_1.70.0     knitr_1.34             jsonlite_1.7.2        
## [16] annotate_1.70.0        png_0.1-7              shiny_1.6.0           
## [19] compiler_4.1.1         httr_1.4.2             assertthat_0.2.1      
## [22] Matrix_1.3-4           fastmap_1.1.0          later_1.3.0           
## [25] htmltools_0.5.2        tools_4.1.1            gtable_0.3.0          
## [28] glue_1.4.2             GenomeInfoDbData_1.2.6 Rcpp_1.0.7            
## [31] jquerylib_0.1.4        vctrs_0.3.8            Biostrings_2.60.2     
## [34] svglite_2.0.0          xfun_0.25              stringr_1.4.0         
## [37] testthat_3.0.4         rvest_1.0.1            mime_0.11             
## [40] lifecycle_1.0.0        XML_3.99-0.7           zlibbioc_1.38.0       
## [43] MASS_7.3-54            scales_1.1.1           promises_1.2.0.1      
## [46] RColorBrewer_1.1-2     yaml_2.2.1             memoise_2.0.0         
## [49] gridExtra_2.3          sass_0.4.0             reshape_0.8.8         
## [52] stringi_1.7.4          RSQLite_2.2.8          highr_0.9             
## [55] genefilter_1.74.0      desc_1.3.0             caTools_1.18.2        
## [58] BiocParallel_1.26.2    rlang_0.4.11           pkgconfig_2.0.3       
## [61] systemfonts_1.0.2      bitops_1.0-7           evaluate_0.14         
## [64] lattice_0.20-45        purrr_0.3.4            labeling_0.4.2        
## [67] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.1.1      
## [70] plyr_1.8.6             magrittr_2.0.1         R6_2.5.1              
## [73] generics_0.1.0         DelayedArray_0.18.0    DBI_1.1.1             
## [76] pillar_1.6.2           withr_2.4.2            survival_3.2-13       
## [79] KEGGREST_1.32.0        RCurl_1.98-1.4         crayon_1.4.1          
## [82] KernSmooth_2.23-20     utf8_1.2.2             rmarkdown_2.10        
## [85] locfit_1.5-9.4         grid_4.1.1             blob_1.2.2            
## [88] digest_0.6.27          webshot_0.5.2          xtable_1.8-4          
## [91] httpuv_1.6.2           munsell_0.5.0          viridisLite_0.4.0     
## [94] bslib_0.3.0

END of report